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Search of human proteins with 12383051
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|12383051 transmembrane protein with EGF-like and two
follistatin-like domains 2 [Homo sapiens]
(374 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|12383051 transmembrane protein with EGF-like and two follista... 805 0.0
gi|29568105 transmembrane protein with EGF-like and two follista... 389 e-108
gi|54873613 agrin [Homo sapiens] 109 5e-24
gi|5453652 follistatin isoform FST317 precursor [Homo sapiens] 70 4e-12
gi|7242222 follistatin isoform FST344 precursor [Homo sapiens] 70 4e-12
gi|4502461 betacellulin [Homo sapiens] 61 1e-09
gi|153791414 transforming growth factor, alpha isoform 2 [Homo s... 59 9e-09
gi|4507461 transforming growth factor, alpha isoform 1 [Homo sap... 59 9e-09
gi|190358524 follistatin-like 5 isoform c [Homo sapiens] 57 4e-08
gi|190358522 follistatin-like 5 isoform b [Homo sapiens] 57 4e-08
gi|190358520 follistatin-like 5 isoform a [Homo sapiens] 57 4e-08
gi|78190498 secreted modular calcium-binding protein 1 isoform 1... 54 2e-07
gi|11545873 secreted modular calcium-binding protein 1 isoform 2... 54 2e-07
gi|4557567 epiregulin preproprotein [Homo sapiens] 54 2e-07
gi|5031701 follistatin-like 3 glycoprotein precursor [Homo sapiens] 54 3e-07
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 53 4e-07
gi|148833508 notch1 preproprotein [Homo sapiens] 53 4e-07
gi|24041035 notch 2 preproprotein [Homo sapiens] 52 9e-07
gi|4502199 amphiregulin preproprotein [Homo sapiens] 52 1e-06
gi|113415639 PREDICTED: amphiregulin B [Homo sapiens] 52 1e-06
gi|54792136 follistatin-like 4 [Homo sapiens] 51 2e-06
gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens] 50 3e-06
gi|134244285 Notch homolog 3 [Homo sapiens] 49 7e-06
gi|5901956 follistatin-like 1 precursor [Homo sapiens] 49 7e-06
gi|4557679 jagged 1 precursor [Homo sapiens] 47 4e-05
gi|24308277 SPARC related modular calcium binding 2 [Homo sapiens] 47 4e-05
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 46 6e-05
gi|61806622 epithelial mitogen [Homo sapiens] 46 6e-05
gi|74027261 serine peptidase inhibitor, Kazal type 5 isoform b p... 45 1e-04
gi|189163501 serine peptidase inhibitor, Kazal type 5 isoform a ... 45 1e-04
>gi|12383051 transmembrane protein with EGF-like and two
follistatin-like domains 2 [Homo sapiens]
Length = 374
Score = 805 bits (2080), Expect = 0.0
Identities = 374/374 (100%), Positives = 374/374 (100%)
Query: 1 MVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYD 60
MVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYD
Sbjct: 1 MVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYD 60
Query: 61 DRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAA 120
DRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAA
Sbjct: 61 DRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAA 120
Query: 121 CKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWC 180
CKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWC
Sbjct: 121 CKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWC 180
Query: 181 VCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDG 240
VCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDG
Sbjct: 181 VCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDG 240
Query: 241 HYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHC 300
HYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHC
Sbjct: 241 HYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHC 300
Query: 301 EKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRKCPRSNRIHRQKQNTGH 360
EKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRKCPRSNRIHRQKQNTGH
Sbjct: 301 EKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRKCPRSNRIHRQKQNTGH 360
Query: 361 YSSDNTTRASTRLI 374
YSSDNTTRASTRLI
Sbjct: 361 YSSDNTTRASTRLI 374
>gi|29568105 transmembrane protein with EGF-like and two
follistatin-like domains 1 [Homo sapiens]
Length = 380
Score = 389 bits (999), Expect = e-108
Identities = 171/316 (54%), Positives = 236/316 (74%), Gaps = 2/316 (0%)
Query: 55 NCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNEC 114
NCS + RE+D+ +CD ++CK+ G C GD + C CQF+C+ +Y+PVCGSNG++YQNEC
Sbjct: 63 NCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNEC 122
Query: 115 YLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDED 174
+LR+AACK Q EI V++ G C +D GSGSG+G EGSG ++ S C C++ AECDED
Sbjct: 123 FLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDED 182
Query: 175 AEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRC--QDNTT 232
AE+V CVCNIDCS +FNP+CASDG SY+N C ++EASC KQE+I++ LG C D+T+
Sbjct: 183 AENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTS 242
Query: 233 TTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCD 292
K +DG R D + +++ E+ +H+PCPE+ NG+C+HGKCE + Q+ SCRC+
Sbjct: 243 LLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCE 302
Query: 293 AGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRKCPRSNRIH 352
+GYTGQHCEK D+S+LYVVP + +VLIAA+IG +QIA+I +V+CITRKCP++NR
Sbjct: 303 SGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNRGR 362
Query: 353 RQKQNTGHYSSDNTTR 368
RQKQN GH++SD ++R
Sbjct: 363 RQKQNLGHFTSDTSSR 378
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 109 bits (272), Expect = 5e-24
Identities = 88/299 (29%), Positives = 122/299 (40%), Gaps = 17/299 (5%)
Query: 9 QCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTG---WNCSGYDDREND 65
QC LCE + P + +A+PV + T S+C S +
Sbjct: 539 QCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGP 598
Query: 66 LFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQS 125
C C F C CVC + PVCGS+G +Y + C LR+AAC QQ+
Sbjct: 599 CETCGDAVCAFGAVC----SAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQT 654
Query: 126 EILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWCVCNID 185
+I G C A GSG GSGE E C Q G DED+ED CVC+
Sbjct: 655 QIEEARAGPCE-QAECGSGGS---GSGEDGDCEQELCR--QRGGIWDEDSEDGPCVCDFS 708
Query: 186 CSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNT-TTTTKSEDGHYAR 244
C +P+C SDG +Y C++K+A C+ Q + V + G C+ T H A+
Sbjct: 709 CQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQ 768
Query: 245 TDYAENANKLEESAREHHIPCPEHYNGFC-MHGKCEHSINMQEPSCRCDAGYTGQHCEK 302
T Y + + + CP C HG + + C C G G C++
Sbjct: 769 TPYGCCQDNITAARGVGLAGCPSACQ--CNPHGSYGGTCDPATGQCSCRPGVGGLRCDR 825
Score = 81.3 bits (199), Expect = 1e-15
Identities = 47/155 (30%), Positives = 70/155 (45%), Gaps = 20/155 (12%)
Query: 74 CKFDGECLRIGDTVTCVC-QFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSE 132
C+F+ CL C C + C+ Y PVC +G +Y ++C+ +QA C+QQ I +
Sbjct: 399 CRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQ 458
Query: 133 GSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFN 192
G C D GV C FGA C C C CS ++
Sbjct: 459 GPC--DQAPSPCLGVQ----------------CAFGATCAVKNGQAACECLQACSSL-YD 499
Query: 193 PLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRC 227
P+C SDG +Y +AC+++ +C +I+V G C
Sbjct: 500 PVCGSDGVTYGSACELEATACTLGREIQVARKGPC 534
Score = 80.5 bits (197), Expect = 2e-15
Identities = 48/155 (30%), Positives = 64/155 (41%), Gaps = 27/155 (17%)
Query: 74 CKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEG 133
C F C C C C++ Y PVCGS+G +Y + C L AC EI V +G
Sbjct: 473 CAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKG 532
Query: 134 SCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNP 193
C C C+FGA C +AE CVC +C P
Sbjct: 533 PC------------------------DRCGQCRFGALC--EAETGRCVCPSECVAL-AQP 565
Query: 194 LCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQ 228
+C SDG +Y + C + +C Q + V S G C+
Sbjct: 566 VCGSDGHTYPSECMLHVHACTHQISLHVASAGPCE 600
Score = 78.2 bits (191), Expect = 1e-14
Identities = 45/143 (31%), Positives = 64/143 (44%), Gaps = 22/143 (15%)
Query: 88 TCVCQFK-CNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDG 146
+CVC+ C + PVCGS+ +Y NEC L++A C QQ I ++S G C
Sbjct: 194 SCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPC----------- 242
Query: 147 VHEGSGETSQKETSTCDICQFGAECDEDAEDVW--CVCNIDCSQTNFNPLCASDGKSYDN 204
GS + T C FG+ C A+ + C+C C +C SDG Y
Sbjct: 243 ---GSRDPCSNVT-----CSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPG 294
Query: 205 ACQIKEASCQKQEKIEVMSLGRC 227
CQ+ +C +QE + G C
Sbjct: 295 ECQLLRRACARQENVFKKFDGPC 317
Score = 67.4 bits (163), Expect = 2e-11
Identities = 36/119 (30%), Positives = 56/119 (47%), Gaps = 4/119 (3%)
Query: 121 CKQQSEILVVSEGSCATDAGS-GSGDGVHEGSGETSQKETSTCDI--CQFGAECDEDAED 177
C+Q + + G G G + E +TC C+FGA C E++
Sbjct: 859 CEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGS 918
Query: 178 VWCVCN-IDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTT 235
CVC + C + N +C SDG +Y N CQ+K +C++ +I + SLG CQ+ +T
Sbjct: 919 AHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPST 977
Score = 62.0 bits (149), Expect = 8e-10
Identities = 52/214 (24%), Positives = 71/214 (33%), Gaps = 55/214 (25%)
Query: 69 CDTNTCKFDGECLRIGD--TVTCVCQFKCNN-DYVPVCGSNGESYQNECYLRQAACKQQS 125
C TC F C R D T +C+C C VCGS+G Y EC L + AC +Q
Sbjct: 248 CSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQE 307
Query: 126 EILVVSEGSC---------------------------------ATDAGSGSGDGV----- 147
+ +G C A A DGV
Sbjct: 308 NVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYEND 367
Query: 148 ----HEGSGETSQKETSTCDICQ----------FGAECDEDAEDVWCVCNIDCSQTNFNP 193
G+ + CQ F A C C C+ + P
Sbjct: 368 CVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRP 427
Query: 194 LCASDGKSYDNACQIKEASCQKQEKIEVMSLGRC 227
+CA DG++YD+ C ++A C++Q I G C
Sbjct: 428 VCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPC 461
Score = 55.1 bits (131), Expect = 1e-07
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 164 ICQFGAECDEDAED---VWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIE 220
+C FGA C+ +AE CVC + P+C SD +Y N C+++ A C +Q +I
Sbjct: 176 LCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIR 235
Query: 221 VMSLGRC 227
++S G C
Sbjct: 236 LLSRGPC 242
Score = 50.1 bits (118), Expect = 3e-06
Identities = 25/69 (36%), Positives = 35/69 (50%), Gaps = 2/69 (2%)
Query: 69 CDTNTCKFDGECLRIGDTVTCVC-QFKCNN-DYVPVCGSNGESYQNECYLRQAACKQQSE 126
C C+F C+ + CVC C + VCGS+G +Y NEC L+ AC+Q +
Sbjct: 901 CAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQ 960
Query: 127 ILVVSEGSC 135
I + S G C
Sbjct: 961 ISIQSLGPC 969
>gi|5453652 follistatin isoform FST317 precursor [Homo sapiens]
Length = 317
Score = 69.7 bits (169), Expect = 4e-12
Identities = 45/145 (31%), Positives = 70/145 (48%), Gaps = 27/145 (18%)
Query: 89 CVCQFKCNNDYV--PVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDG 146
CVC C+N PVCG +G++Y+NEC L +A CK+Q E+ V +G C
Sbjct: 116 CVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRC----------- 164
Query: 147 VHEGSGETSQKETSTCDICQFGAECDED-AEDVWCV-CNIDCSQ--TNFNPLCASDGKSY 202
K+T C + C D + +CV CN C + ++ LC +DG +Y
Sbjct: 165 ----------KKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTY 214
Query: 203 DNACQIKEASCQKQEKIEVMSLGRC 227
+AC +++A+C I + G+C
Sbjct: 215 SSACHLRKATCLLGRSIGLAYEGKC 239
Score = 53.1 bits (126), Expect = 4e-07
Identities = 28/74 (37%), Positives = 42/74 (56%), Gaps = 2/74 (2%)
Query: 157 KETSTCDICQFGAECDEDAEDV-WCVCNIDCSQTNFN-PLCASDGKSYDNACQIKEASCQ 214
KET C G +C + ++ CVC DCS + P+C DGK+Y N C + +A C+
Sbjct: 92 KETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCK 151
Query: 215 KQEKIEVMSLGRCQ 228
+Q ++EV GRC+
Sbjct: 152 EQPELEVQYQGRCK 165
>gi|7242222 follistatin isoform FST344 precursor [Homo sapiens]
Length = 344
Score = 69.7 bits (169), Expect = 4e-12
Identities = 45/145 (31%), Positives = 70/145 (48%), Gaps = 27/145 (18%)
Query: 89 CVCQFKCNNDYV--PVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDG 146
CVC C+N PVCG +G++Y+NEC L +A CK+Q E+ V +G C
Sbjct: 116 CVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRC----------- 164
Query: 147 VHEGSGETSQKETSTCDICQFGAECDED-AEDVWCV-CNIDCSQ--TNFNPLCASDGKSY 202
K+T C + C D + +CV CN C + ++ LC +DG +Y
Sbjct: 165 ----------KKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTY 214
Query: 203 DNACQIKEASCQKQEKIEVMSLGRC 227
+AC +++A+C I + G+C
Sbjct: 215 SSACHLRKATCLLGRSIGLAYEGKC 239
Score = 53.1 bits (126), Expect = 4e-07
Identities = 28/74 (37%), Positives = 42/74 (56%), Gaps = 2/74 (2%)
Query: 157 KETSTCDICQFGAECDEDAEDV-WCVCNIDCSQTNFN-PLCASDGKSYDNACQIKEASCQ 214
KET C G +C + ++ CVC DCS + P+C DGK+Y N C + +A C+
Sbjct: 92 KETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCK 151
Query: 215 KQEKIEVMSLGRCQ 228
+Q ++EV GRC+
Sbjct: 152 EQPELEVQYQGRCK 165
>gi|4502461 betacellulin [Homo sapiens]
Length = 178
Score = 61.2 bits (147), Expect = 1e-09
Identities = 37/153 (24%), Positives = 64/153 (41%), Gaps = 27/153 (17%)
Query: 206 CQIKEASCQKQEKIEVMSLGRCQDN--TTTTTKSEDGHYARTDYAENANKLEESAREHHI 263
C + + + + + + G ++N TTT GH++R
Sbjct: 28 CVVADGNSTRSPETNGLLCGDPEENCAATTTQSKRKGHFSR------------------- 68
Query: 264 PCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIA 323
CP+ Y +C+ G+C + Q PSC CD GY G CE+ D L G +L+
Sbjct: 69 -CPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRG-----QILVI 122
Query: 324 AVIGTIQIAVICVVVLCITRKCPRSNRIHRQKQ 356
+I + + +I V+ +C R R ++K+
Sbjct: 123 CLIAVMVVFIILVIGVCTCCHPLRKRRKRKKKE 155
>gi|153791414 transforming growth factor, alpha isoform 2 [Homo
sapiens]
Length = 159
Score = 58.5 bits (140), Expect = 9e-09
Identities = 27/83 (32%), Positives = 42/83 (50%), Gaps = 5/83 (6%)
Query: 261 HHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYV 320
H CP+ + FC HG C + +P+C C +GY G CE D +L VV + Q +
Sbjct: 42 HFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHAD--LLAVVAASQKKQAI 99
Query: 321 LIAAVIGTIQIAVI---CVVVLC 340
V+ + +AV+ CV++ C
Sbjct: 100 TALVVVSIVALAVLIITCVLIHC 122
>gi|4507461 transforming growth factor, alpha isoform 1 [Homo
sapiens]
Length = 160
Score = 58.5 bits (140), Expect = 9e-09
Identities = 27/83 (32%), Positives = 42/83 (50%), Gaps = 5/83 (6%)
Query: 261 HHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYV 320
H CP+ + FC HG C + +P+C C +GY G CE D +L VV + Q +
Sbjct: 43 HFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHAD--LLAVVAASQKKQAI 100
Query: 321 LIAAVIGTIQIAVI---CVVVLC 340
V+ + +AV+ CV++ C
Sbjct: 101 TALVVVSIVALAVLIITCVLIHC 123
>gi|190358524 follistatin-like 5 isoform c [Homo sapiens]
Length = 837
Score = 56.6 bits (135), Expect = 4e-08
Identities = 24/69 (34%), Positives = 35/69 (50%), Gaps = 2/69 (2%)
Query: 69 CDTNTCKFDGECLRIGDT--VTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSE 126
C+ C C+ +T C C C Y PVCGS+GE Y+N C + +AAC ++ +
Sbjct: 64 CENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACLKKQK 123
Query: 127 ILVVSEGSC 135
I +V C
Sbjct: 124 ITIVHNEDC 132
Score = 47.4 bits (111), Expect = 2e-05
Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 3/65 (4%)
Query: 165 CQFGAECDEDAE--DVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVM 222
C G C E C C +D + ++ P+C SDG+ Y+N C++ A+C K++KI ++
Sbjct: 69 CGLGRHCVTSRETGQAECAC-MDLCKRHYKPVCGSDGEFYENHCEVHRAACLKKQKITIV 127
Query: 223 SLGRC 227
C
Sbjct: 128 HNEDC 132
>gi|190358522 follistatin-like 5 isoform b [Homo sapiens]
Length = 846
Score = 56.6 bits (135), Expect = 4e-08
Identities = 24/69 (34%), Positives = 35/69 (50%), Gaps = 2/69 (2%)
Query: 69 CDTNTCKFDGECLRIGDT--VTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSE 126
C+ C C+ +T C C C Y PVCGS+GE Y+N C + +AAC ++ +
Sbjct: 64 CENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACLKKQK 123
Query: 127 ILVVSEGSC 135
I +V C
Sbjct: 124 ITIVHNEDC 132
Score = 47.4 bits (111), Expect = 2e-05
Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 3/65 (4%)
Query: 165 CQFGAECDEDAE--DVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVM 222
C G C E C C +D + ++ P+C SDG+ Y+N C++ A+C K++KI ++
Sbjct: 69 CGLGRHCVTSRETGQAECAC-MDLCKRHYKPVCGSDGEFYENHCEVHRAACLKKQKITIV 127
Query: 223 SLGRC 227
C
Sbjct: 128 HNEDC 132
>gi|190358520 follistatin-like 5 isoform a [Homo sapiens]
Length = 847
Score = 56.6 bits (135), Expect = 4e-08
Identities = 24/69 (34%), Positives = 35/69 (50%), Gaps = 2/69 (2%)
Query: 69 CDTNTCKFDGECLRIGDT--VTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSE 126
C+ C C+ +T C C C Y PVCGS+GE Y+N C + +AAC ++ +
Sbjct: 65 CENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACLKKQK 124
Query: 127 ILVVSEGSC 135
I +V C
Sbjct: 125 ITIVHNEDC 133
Score = 47.4 bits (111), Expect = 2e-05
Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 3/65 (4%)
Query: 165 CQFGAECDEDAE--DVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVM 222
C G C E C C +D + ++ P+C SDG+ Y+N C++ A+C K++KI ++
Sbjct: 70 CGLGRHCVTSRETGQAECAC-MDLCKRHYKPVCGSDGEFYENHCEVHRAACLKKQKITIV 128
Query: 223 SLGRC 227
C
Sbjct: 129 HNEDC 133
>gi|78190498 secreted modular calcium-binding protein 1 isoform 1
[Homo sapiens]
Length = 435
Score = 54.3 bits (129), Expect = 2e-07
Identities = 27/76 (35%), Positives = 43/76 (56%), Gaps = 6/76 (7%)
Query: 182 CNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGH 241
CN+ CS+T P+CASDG+SY++ C+ + A C + + V+ GRC+D + + E
Sbjct: 43 CNLHCSRTQPKPICASDGRSYESMCEYQRAKC-RDPTLGVVHRGRCKDAGQSKCRLE--- 98
Query: 242 YARTDYAENANKLEES 257
R E A K +E+
Sbjct: 99 --RAQALEQAKKPQEA 112
Score = 35.8 bits (81), Expect = 0.064
Identities = 30/111 (27%), Positives = 46/111 (41%), Gaps = 10/111 (9%)
Query: 91 CQFKCNNDYV-PVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHE 149
C C+ P+C S+G SY++ C ++A C+ + + VV G C DAG
Sbjct: 43 CNLHCSRTQPKPICASDGRSYESMCEYQRAKCRDPT-LGVVHRGRC-KDAGQSKCRLERA 100
Query: 150 GSGETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGK 200
+ E ++K F EC ED C+ + T + DGK
Sbjct: 101 QALEQAKKPQEAV----FVPECGEDGSFTQVQCH---TYTGYCWCVTPDGK 144
>gi|11545873 secreted modular calcium-binding protein 1 isoform 2
[Homo sapiens]
Length = 434
Score = 54.3 bits (129), Expect = 2e-07
Identities = 27/76 (35%), Positives = 43/76 (56%), Gaps = 6/76 (7%)
Query: 182 CNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGH 241
CN+ CS+T P+CASDG+SY++ C+ + A C + + V+ GRC+D + + E
Sbjct: 43 CNLHCSRTQPKPICASDGRSYESMCEYQRAKC-RDPTLGVVHRGRCKDAGQSKCRLE--- 98
Query: 242 YARTDYAENANKLEES 257
R E A K +E+
Sbjct: 99 --RAQALEQAKKPQEA 112
Score = 35.8 bits (81), Expect = 0.064
Identities = 30/111 (27%), Positives = 46/111 (41%), Gaps = 10/111 (9%)
Query: 91 CQFKCNNDYV-PVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHE 149
C C+ P+C S+G SY++ C ++A C+ + + VV G C DAG
Sbjct: 43 CNLHCSRTQPKPICASDGRSYESMCEYQRAKCRDPT-LGVVHRGRC-KDAGQSKCRLERA 100
Query: 150 GSGETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGK 200
+ E ++K F EC ED C+ + T + DGK
Sbjct: 101 QALEQAKKPQEAV----FVPECGEDGSFTQVQCH---TYTGYCWCVTPDGK 144
>gi|4557567 epiregulin preproprotein [Homo sapiens]
Length = 169
Score = 53.9 bits (128), Expect = 2e-07
Identities = 28/102 (27%), Positives = 44/102 (43%), Gaps = 18/102 (17%)
Query: 225 GRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINM 284
G DN T ++ED A+ C NG+C+HG+C + ++M
Sbjct: 42 GESSDNCTALVQTEDN--------------PRVAQVSITKCSSDMNGYCLHGQCIYLVDM 87
Query: 285 QEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVI 326
+ CRC+ GYTG CE V P+ +YV + ++
Sbjct: 88 SQNYCRCEVGYTGVRCE----HFFLTVHQPLSKEYVALTVIL 125
>gi|5031701 follistatin-like 3 glycoprotein precursor [Homo sapiens]
Length = 263
Score = 53.5 bits (127), Expect = 3e-07
Identities = 41/165 (24%), Positives = 65/165 (39%), Gaps = 26/165 (15%)
Query: 69 CDTNTCKFDGECLRIGDTVTCVCQFKCNN--DYVPVCGSNGESYQNECYLRQAACKQQSE 126
CD C C +G C C C+ + VCGS+G +Y++EC LR A C+ +
Sbjct: 99 CDGVECGPGKACRMLGGRPRCECAPDCSGLPARLQVCGSDGATYRDECELRAARCRGHPD 158
Query: 127 ILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFG-AECDEDAEDVWCVCNID 185
+ V+ G C + +C + Q G A C VC
Sbjct: 159 LSVMYRGRC------------RKSCEHVVCPRPQSCVVDQTGSAHC--------VVCRAA 198
Query: 186 CSQTNFNP---LCASDGKSYDNACQIKEASCQKQEKIEVMSLGRC 227
+P LC ++ +Y ++C +++A+C I V G C
Sbjct: 199 PCPVPSSPGQELCGNNNVTYISSCHMRQATCFLGRSIGVRHAGSC 243
Score = 40.0 bits (92), Expect = 0.003
Identities = 18/50 (36%), Positives = 27/50 (54%), Gaps = 1/50 (2%)
Query: 180 CVCNIDCSQTNFN-PLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQ 228
C C DCS +C SDG +Y + C+++ A C+ + VM GRC+
Sbjct: 119 CECAPDCSGLPARLQVCGSDGATYRDECELRAARCRGHPDLSVMYRGRCR 168
Score = 34.7 bits (78), Expect = 0.14
Identities = 19/57 (33%), Positives = 29/57 (50%), Gaps = 7/57 (12%)
Query: 102 VCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKE 158
+CG+N +Y + C++RQA C I V GSCA G GE++++E
Sbjct: 210 LCGNNNVTYISSCHMRQATCFLGRSIGVRHAGSCA-------GTPEEPPGGESAEEE 259
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 53.1 bits (126), Expect = 4e-07
Identities = 63/274 (22%), Positives = 91/274 (33%), Gaps = 68/274 (24%)
Query: 69 CDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEIL 128
C C C+ G+ TC C D +C S +EC + C S
Sbjct: 835 CAPVGCSMYARCISEGEDATCQCLKGFAGDG-KLC-----SDIDECEMGVPVCPPASSKC 888
Query: 129 VVSEGSCATDAGSG-SGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCS 187
+ +EG G GDG+H D CQ G C N C+
Sbjct: 889 INTEGGYVCRCSEGYQGDGIH----------CLDIDECQLGEHS--------CGENASCT 930
Query: 188 QTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDY 247
T C G+ + C D+T ED H+
Sbjct: 931 NTEGGYTCMCAGRLSEPGLI-------------------CPDSTPPPHLREDDHHY---- 967
Query: 248 AENANKLEESAREHHIPCPEHYNGFCMH-GKCEHSINMQEPSCRCDAGYTGQHCEKKDYS 306
S R CP ++G+C+H G C + + + +C C GY G+ C+ +D
Sbjct: 968 ---------SVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLK 1018
Query: 307 VLYV-VPGPVRFQYVLIAAVIGTIQIAVICVVVL 339
+ G + Q V++ AV CVVVL
Sbjct: 1019 WWELRHAGHGQQQKVIVVAV---------CVVVL 1043
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 53.1 bits (126), Expect = 4e-07
Identities = 61/266 (22%), Positives = 91/266 (34%), Gaps = 43/266 (16%)
Query: 52 TGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQ 111
TG NC E ++ C N CK G C+ +T C C + Y C +
Sbjct: 250 TGQNC------EENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQY---CTED----V 296
Query: 112 NECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTC--DICQFGA 169
+EC L AC+ + G+C G + V+ +GE + C C GA
Sbjct: 297 DECQLMPNACQ--------NGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGA 348
Query: 170 ECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQD 229
C + +C +C LC + N C E S + ++ C
Sbjct: 349 TCHDRVASFYC----ECPHGRTGLLCHLNDACISNPC--NEGSNCDTNPVNGKAICTCPS 402
Query: 230 NTTTTTKSEDGHYAR--TDYAENANKLEESAREHHIPCPEHYNG--------FCMHGKCE 279
T S+D + E+A K + C + Y G C+ C+
Sbjct: 403 GYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQ 462
Query: 280 HSI----NMQEPSCRCDAGYTGQHCE 301
+ + E C C GY G HCE
Sbjct: 463 NDATCLDQIGEFQCICMPGYEGVHCE 488
Score = 51.6 bits (122), Expect = 1e-06
Identities = 69/314 (21%), Positives = 103/314 (32%), Gaps = 85/314 (27%)
Query: 48 CQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNG 107
C PTGW E D+ C + C+ C C CQ G N
Sbjct: 855 CVCPTGWQGQTC---EVDINECVLSPCRHGASCQNTHGGYRCHCQ-------AGYSGRNC 904
Query: 108 ESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTC--DIC 165
E+ ++C R C + GSC + D + G +++ + C D C
Sbjct: 905 ETDIDDC--RPNPCH--------NGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPC 954
Query: 166 QFGAECDEDAEDVWCVCNI------------DCSQTN-FNPLCASDGKSY---------- 202
+ GA C + + C C DC++++ FN DG +
Sbjct: 955 RNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFT 1014
Query: 203 DNACQIKEASCQKQEKIEVMSLGRCQDNT----TTTTKSEDG-------HYARTDYAENA 251
+ CQ C Q + G CQD T + G H+ + +N
Sbjct: 1015 GSYCQHDVNECDSQPCLHG---GTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNG 1071
Query: 252 NKLEESAREHHIPCPEHYNGF-----------------------CMHGK-CEHSINMQEP 287
K ++ ++ CP + G C HG C + N
Sbjct: 1072 GKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHH- 1130
Query: 288 SCRCDAGYTGQHCE 301
CRC AGYTG +CE
Sbjct: 1131 -CRCQAGYTGSYCE 1143
Score = 51.2 bits (121), Expect = 1e-06
Identities = 64/304 (21%), Positives = 103/304 (33%), Gaps = 73/304 (24%)
Query: 48 CQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSN- 106
C GW+ + D N+ C++N C G C + C C+ + P C +N
Sbjct: 739 CDCDPGWSGTNCDINNNE---CESNPCVNGGTCKDMTSGYVCTCREGFSG---PNCQTNI 792
Query: 107 GESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTC--DI 164
E N C +++G+C D + + +G T + + C
Sbjct: 793 NECASNPC---------------LNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSP 837
Query: 165 CQFGAEC--DEDAEDVWCV---------CNIDCSQTNFNPL-----CASDGKSYDNACQI 208
C+ G EC ED E CV C +D ++ +P C + Y CQ
Sbjct: 838 CRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQA 897
Query: 209 KEASCQKQEKIE------VMSLGRCQDNTTT-----------TTKSEDGHYARTDYAENA 251
+ + I+ + G C D T T ED + +D N
Sbjct: 898 GYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNG 957
Query: 252 NKLEESAREHHIPCPEHYNGF-------------CMH-GKCEHSINMQEPSCRCDAGYTG 297
+ + CP ++G C + G C IN +C C G+TG
Sbjct: 958 ANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGIN--SFTCLCPPGFTG 1015
Query: 298 QHCE 301
+C+
Sbjct: 1016 SYCQ 1019
Score = 43.5 bits (101), Expect = 3e-04
Identities = 54/256 (21%), Positives = 82/256 (32%), Gaps = 53/256 (20%)
Query: 69 CDTNTCKFDGECLRIGDTVTCVCQFKCNNDYV-PVCGSNGESYQNECYLRQAACKQQSEI 127
C +N C C +C C + Y P C + + EC L C+
Sbjct: 376 CISNPCNEGSNCDTNPVNGKAICT--CPSGYTGPACSQDVD----ECSLGANPCEHA--- 426
Query: 128 LVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTC--DICQFGAECDEDAEDVWCVC--- 182
G C GS + +G + + + C + CQ A C + + C+C
Sbjct: 427 -----GKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPG 481
Query: 183 --NIDCSQTNFNPLCASDGKSYDNAC--QIKEASCQKQEKIEVMSLGRCQDNTTTTTKSE 238
+ C CAS ++ C +I E C+ C T
Sbjct: 482 YEGVHCEVNTDE--CASSPCLHNGRCLDKINEFQCE------------CPTGFTGHLCQY 527
Query: 239 DGHYARTDYAENANKLEESAREHHIPCPEHYNGF-------------CMHGKCEHSINMQ 285
D + +N K + + C E Y G C +G C+ +
Sbjct: 528 DVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATF 587
Query: 286 EPSCRCDAGYTGQHCE 301
+C C GYTG HCE
Sbjct: 588 --TCLCRPGYTGHHCE 601
Score = 42.4 bits (98), Expect = 7e-04
Identities = 63/276 (22%), Positives = 100/276 (36%), Gaps = 60/276 (21%)
Query: 48 CQTPTGW--NCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGS 105
C+ PTG+ + YD E C + CK +CL +T TCVC + V
Sbjct: 514 CECPTGFTGHLCQYDVDE-----CASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEV--D 566
Query: 106 NGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDIC 165
E + C+ +CK V+ +C G G H ET+ E S+ C
Sbjct: 567 IDECDPDPCHY--GSCKDG-----VATFTCLCRPGY---TGHH---CETNINECSS-QPC 612
Query: 166 QFGAECDEDAEDVWCVC-----------NID--CSQTNFNPLCASDGKSYDNACQIKEAS 212
+ G C + C C N+D S + C Y+ AC+
Sbjct: 613 RHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTG 672
Query: 213 CQKQEKIEVMSLGRCQDNTTT-------TTKSEDGHYARTDYAENANKLEESAREHHIPC 265
I+ + C + T T + +G++ T +E N+ +
Sbjct: 673 SMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSE-VNECNSNP------- 724
Query: 266 PEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCE 301
C+HG C S+N + C CD G++G +C+
Sbjct: 725 -------CVHGACRDSLNGYK--CDCDPGWSGTNCD 751
Score = 42.0 bits (97), Expect = 9e-04
Identities = 56/266 (21%), Positives = 85/266 (31%), Gaps = 68/266 (25%)
Query: 63 ENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACK 122
E D+ C +N C+ D CL C+C + C N + + L C
Sbjct: 450 EIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVH---CEVNTDECASSPCLHNGRCL 506
Query: 123 QQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDI--CQFGAECDEDAEDVWC 180
+ ++E C G +G Q + C C+ GA+C + C
Sbjct: 507 DK-----INEFQCECPTGF---------TGHLCQYDVDECASTPCKNGAKCLDGPNTYTC 552
Query: 181 VCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTT----K 236
VC + T+ C++ C + G C+D T T
Sbjct: 553 VCTEGYTGTH---------------CEVDIDECDP----DPCHYGSCKDGVATFTCLCRP 593
Query: 237 SEDGHYARTDYAENANKLEESAREHHIPCPEHYNG---FCMHG----KCEHSINMQEPS- 288
GH+ T N N+ H C + N FC+ G CE +++ S
Sbjct: 594 GYTGHHCET----NINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSP 649
Query: 289 --------------CRCDAGYTGQHC 300
C C+ GYTG C
Sbjct: 650 CDSGTCLDKIDGYECACEPGYTGSMC 675
Score = 41.6 bits (96), Expect = 0.001
Identities = 66/305 (21%), Positives = 98/305 (32%), Gaps = 70/305 (22%)
Query: 48 CQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNG 107
C+ P GW SG ++ D C +N C G+CL + C C + P C +
Sbjct: 127 CRCPPGW--SGKSCQQADP--CASNPCANGGQCLPFEASYICHCPPSFHG---PTCRQD- 178
Query: 108 ESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDI--C 165
NEC + C+ G+C + GS +G ++ C C
Sbjct: 179 ---VNECGQKPGLCRHG--------GTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPC 227
Query: 166 QFGAECDEDAEDVW-CVC-----------NID-CSQTNFNP--LCASDGKSYDNACQIKE 210
Q G C + C C NID C N C +Y+ C +
Sbjct: 228 QNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEW 287
Query: 211 ASCQKQEKIEVMSL--GRCQDNTTTTTKSEDGH-------YARTDYAENANKLEESAREH 261
E ++ L CQ N T + G+ + D +EN + +A H
Sbjct: 288 TGQYCTEDVDECQLMPNACQ-NGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFH 346
Query: 262 HIPCPE------------------HYNGFCMHGKCEHSINMQ------EPSCRCDAGYTG 297
C + H N C+ C N + C C +GYTG
Sbjct: 347 GATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTG 406
Query: 298 QHCEK 302
C +
Sbjct: 407 PACSQ 411
Score = 41.6 bits (96), Expect = 0.001
Identities = 69/320 (21%), Positives = 110/320 (34%), Gaps = 80/320 (25%)
Query: 46 SDCQ-TPTGWNC---SGYDDR--ENDLFLCDTNTCKFDGECLRIGDTVTCVCQ--FK--- 94
+ CQ T G+ C +GY R E D+ C N C G C +T C C F+
Sbjct: 882 ASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTF 941
Query: 95 CNNDYVPVCGS----NG-------ESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGS 143
C D + C S NG +SY C + ++ +E SC G
Sbjct: 942 CEED-INECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFN--GGTC 998
Query: 144 GDGVHEGS--------GETSQKETSTCDI--CQFGAECDEDAEDVWCVCNIDCSQTNFNP 193
DG++ + G Q + + CD C G C + C C + N
Sbjct: 999 VDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQN 1058
Query: 194 L--------CASDGKSYDNA---------------CQIKEASCQ---KQEKIEVMSL--- 224
L C + GK + C + SC+ +++ ++V L
Sbjct: 1059 LVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQH 1118
Query: 225 -GRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSIN 283
G C D T Y + + ++ S ++ C ++ G+
Sbjct: 1119 GGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGY----------- 1167
Query: 284 MQEPSCRCDAGYTGQHCEKK 303
SC+C AGY G +C ++
Sbjct: 1168 ----SCKCVAGYHGVNCSEE 1183
Score = 32.3 bits (72), Expect = 0.71
Identities = 55/278 (19%), Positives = 89/278 (32%), Gaps = 38/278 (13%)
Query: 48 CQTPTGW----------NCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNN 97
C+ P+GW +C R+ + C+ G C+ G+T C CQ
Sbjct: 1083 CECPSGWTGLYCDVPSVSCEVAAQRQG---VDVARLCQHGGLCVDAGNTHHCRCQ----- 1134
Query: 98 DYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEG-SCATDAGS---GSGDGVHEGSGE 153
GS E +EC + C+ + G SC AG + + E
Sbjct: 1135 --AGYTGSYCEDLVDEC--SPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSH 1190
Query: 154 TSQKETSTCDICQ-FGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEAS 212
Q + D+ + C + V C N+D +P+ S K ++N + +
Sbjct: 1191 PCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSP-KCFNNGTCVDQVG 1249
Query: 213 CQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIP--CPEHYN 270
RC+ + + + + N R H C N
Sbjct: 1250 GYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVIN 1309
Query: 271 GFCMHGKCEHSINMQEPS-------CRCDAGYTGQHCE 301
G C C++ S C+C AG+ G CE
Sbjct: 1310 G-CKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCE 1346
Score = 28.9 bits (63), Expect = 7.8
Identities = 10/32 (31%), Positives = 18/32 (56%)
Query: 273 CMHGKCEHSINMQEPSCRCDAGYTGQHCEKKD 304
C +G + + E CRC G++G+ C++ D
Sbjct: 111 CRNGGTCDLLTLTEYKCRCPPGWSGKSCQQAD 142
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 52.0 bits (123), Expect = 9e-07
Identities = 67/281 (23%), Positives = 106/281 (37%), Gaps = 53/281 (18%)
Query: 48 CQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNG 107
C+ P G+ SG D E D+ C N C+ G C+ +T +C+C + G G
Sbjct: 897 CECPPGF--SGMDCEE-DIDDCLANPCQNGGSCMDGVNTFSCLC----------LPGFTG 943
Query: 108 ESYQ---NECYLRQAACKQQSEIL-VVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCD 163
+ Q NEC CK V+ +C AG DGVH + E+S
Sbjct: 944 DKCQTDMNECL--SEPCKNGGTCSDYVNSYTCKCQAGF---DGVHCENNINECTESS--- 995
Query: 164 ICQFGAECDEDAEDVWCVCNI---------DCSQTNFNPLCASDGKSYDN------ACQI 208
C G C + C+C + + ++ + +P C ++G D +C +
Sbjct: 996 -CFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHP-CLNEGTCVDGLGTYRCSCPL 1053
Query: 209 KEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTD-----YAENANKLEESAREHHI 263
Q + + S C++ T K + Y + N + A
Sbjct: 1054 GYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRG 1113
Query: 264 PCPEHYNGFCMH-GKCEHSINMQEPSCRCDAGYTGQHCEKK 303
EH C H G C ++ N C+C GYTG +CE++
Sbjct: 1114 VLVEH---LCQHSGVCINAGNTHY--CQCPLGYTGSYCEEQ 1149
Score = 43.9 bits (102), Expect = 2e-04
Identities = 58/260 (22%), Positives = 91/260 (35%), Gaps = 46/260 (17%)
Query: 63 ENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACK 122
E ++ C + C+ G C+ +T C C + + C + + EC L+ AC+
Sbjct: 258 ERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQF---CTEDVD----ECLLQPNACQ 310
Query: 123 QQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDI--CQFGAECDEDAEDVWC 180
+ G+CA G V+ SG+ + C C G+ C + C
Sbjct: 311 --------NGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSC 362
Query: 181 VCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDG 240
+C + LC D N C K A C + + C +ED
Sbjct: 363 MC----PEGKAGLLCHLDDACISNPCH-KGALCDTNP-LNGQYICTCPQGYKGADCTEDV 416
Query: 241 H---YARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINM--QEP-------- 287
A ++ E+A K + H C + Y G +CE IN +P
Sbjct: 417 DECAMANSNPCEHAGKCVNTDGAFHCECLKGYAG----PRCEMDINECHSDPCQNDATCL 472
Query: 288 ------SCRCDAGYTGQHCE 301
+C C G+ G HCE
Sbjct: 473 DKIGGFTCLCMPGFKGVHCE 492
Score = 42.7 bits (99), Expect = 5e-04
Identities = 68/287 (23%), Positives = 99/287 (34%), Gaps = 77/287 (26%)
Query: 48 CQTPTGW---NCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQ--FKCNNDYVPV 102
C GW NC E D C +N C+ G C + + C C+ FK N V +
Sbjct: 743 CLCDAGWVGINC------EVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNI 796
Query: 103 CGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTC 162
E N C +++G+C D + V +G+ Q + C
Sbjct: 797 ----DECASNPC---------------LNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPC 837
Query: 163 --DICQFGAECDEDA--EDVWCVC---------NIDCSQTNFNP-----LCASDGKSYDN 204
+ C+ A C E E C+C ID + P LC + SY
Sbjct: 838 SPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMC 897
Query: 205 ACQIKEASCQKQEKIE------VMSLGRCQDNTTTTT----KSEDGHYARTDYAENANKL 254
C + +E I+ + G C D T + G +TD E ++
Sbjct: 898 ECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSE- 956
Query: 255 EESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCE 301
PC NG G C +N +C+C AG+ G HCE
Sbjct: 957 ---------PCK---NG----GTCSDYVNSY--TCKCQAGFDGVHCE 985
Score = 42.0 bits (97), Expect = 9e-04
Identities = 62/299 (20%), Positives = 99/299 (33%), Gaps = 66/299 (22%)
Query: 48 CQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNG 107
C P G+ + + ++ + ++N C+ G+C+ C +C Y G
Sbjct: 401 CTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHC----ECLKGY---AGPRC 453
Query: 108 ESYQNECYLRQAACKQQSEILVVSEG-SCATDAGSGSGDGVHEGSGETSQKETSTC--DI 164
E NEC+ C+ + L G +C G GVH + E + C +
Sbjct: 454 EMDINECH--SDPCQNDATCLDKIGGFTCLCMPGF---KGVH------CELEINECQSNP 502
Query: 165 CQFGAECDEDAEDVWC---------VCNIDCSQTNFNPL-----CASDGKSYDNACQIKE 210
C +C + C VC ID + P C Y+ C
Sbjct: 503 CVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGF 562
Query: 211 ASCQKQEKI-----EVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPC 265
+E I + G+CQD + T + Y ++ ++ S + C
Sbjct: 563 TGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRC 622
Query: 266 PEHYNGF------------------------CMHGKCEHSINMQEPSCRCDAGYTGQHC 300
+ NG+ C+HG C IN SC C G+TGQ C
Sbjct: 623 IDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRY--SCVCSPGFTGQRC 679
Score = 35.8 bits (81), Expect = 0.064
Identities = 51/207 (24%), Positives = 74/207 (35%), Gaps = 37/207 (17%)
Query: 130 VSEGSCAT-DAGSGSGDGVHEGSGETSQ-KETSTCDICQFGAECDEDAEDVWCVCNI--- 184
V+EG C T G+G GE Q ++ + CQ G C A C
Sbjct: 36 VNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASG 95
Query: 185 ----DCSQTNFNPL-----CASDGK-------SYDNACQIKEASCQKQEKIEVMSLGRCQ 228
DC + +P C + G +Y+ CQ+ + Q +S
Sbjct: 96 FTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCAN 155
Query: 229 DNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEP- 287
+T TT ++ T + K E E IP G C HG +N+
Sbjct: 156 GSTCTTVANQFSCKCLTGFT--GQKCETDVNECDIP------GHCQHGGT--CLNLPGSY 205
Query: 288 SCRCDAGYTGQHCEKKDYSVLYVVPGP 314
C+C G+TGQ+C+ LYV P
Sbjct: 206 QCQCPQGFTGQYCDS-----LYVPCAP 227
Score = 35.8 bits (81), Expect = 0.064
Identities = 67/289 (23%), Positives = 99/289 (34%), Gaps = 63/289 (21%)
Query: 46 SDCQTPTGWNCSGYDDRENDLFLCDT----------NTCKFDGECLRIGDTVTCVCQFKC 95
S C P+GW Y D N CD + C+ G C+ G+T C C
Sbjct: 1085 SQCLCPSGW-AGAYCDVPN--VSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGY 1141
Query: 96 NNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETS 155
Y E +EC C+ + +C+ G + V G
Sbjct: 1142 TGSYC-------EEQLDEC--ASNPCQHGA--------TCSDFIGGYRCECVPGYQGVNC 1184
Query: 156 QKETSTCDI--CQFGAECDEDAEDVWCVC-----------NID-CSQTNFNPLCASDGKS 201
+ E C CQ G C + C C NID C++ P C + G+
Sbjct: 1185 EYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCAR---GPHCLNGGQC 1241
Query: 202 YDNACQIKEASCQ-----KQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEE 256
D +I SC+ E+ E + C N ++ S D DY
Sbjct: 1242 MD---RIGGYSCRCLPGFAGERCEG-DINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFT 1297
Query: 257 SAR-EHHIP-CPEHYNGFCMHG-KCEHSINMQEPS-CRCDAGYTGQHCE 301
E + CP+ C++G C + NM + CRC G++G C+
Sbjct: 1298 GRHCETFVDVCPQMP---CLNGGTCAVASNMPDGFICRCPPGFSGARCQ 1343
>gi|4502199 amphiregulin preproprotein [Homo sapiens]
Length = 252
Score = 51.6 bits (122), Expect = 1e-06
Identities = 42/209 (20%), Positives = 86/209 (41%), Gaps = 24/209 (11%)
Query: 143 SGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASD---G 199
SGD +G TS+ E S+ G+E +E ++ P +D
Sbjct: 41 SGDHSADGFEVTSRSEMSS------GSEISPVSE----------MPSSSEPSSGADYDYS 84
Query: 200 KSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAR 259
+ YDN QI ++E + + N T + + D + +N +
Sbjct: 85 EEYDNEPQIPGYIVDDSVRVE--QVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKK 142
Query: 260 EHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPV-RFQ 318
++ PC + FC+HG+C++ +++ +C+C Y G+ C +K ++ + +
Sbjct: 143 KN--PCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIA 200
Query: 319 YVLIAAVIGTIQIAVICVVVLCITRKCPR 347
IAA + + + + V+ + + R+ R
Sbjct: 201 LAAIAAFMSAVILTAVAVITVQLRRQYVR 229
>gi|113415639 PREDICTED: amphiregulin B [Homo sapiens]
Length = 252
Score = 51.6 bits (122), Expect = 1e-06
Identities = 42/209 (20%), Positives = 86/209 (41%), Gaps = 24/209 (11%)
Query: 143 SGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASD---G 199
SGD +G TS+ E S+ G+E +E ++ P +D
Sbjct: 41 SGDHSADGFEVTSRSEMSS------GSEISPVSE----------MPSSSEPSSGADYDYS 84
Query: 200 KSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAR 259
+ YDN QI ++E + + N T + + D + +N +
Sbjct: 85 EEYDNEPQIPGYIVDDSVRVE--QVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKK 142
Query: 260 EHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPV-RFQ 318
++ PC + FC+HG+C++ +++ +C+C Y G+ C +K ++ + +
Sbjct: 143 KN--PCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIA 200
Query: 319 YVLIAAVIGTIQIAVICVVVLCITRKCPR 347
IAA + + + + V+ + + R+ R
Sbjct: 201 LAAIAAFMSAVILTAVAVITVQLRRQYVR 229
>gi|54792136 follistatin-like 4 [Homo sapiens]
Length = 842
Score = 50.8 bits (120), Expect = 2e-06
Identities = 27/80 (33%), Positives = 32/80 (40%), Gaps = 2/80 (2%)
Query: 58 GYDDRENDLFLCDTNTCKFDGECLRIGDT--VTCVCQFKCNNDYVPVCGSNGESYQNECY 115
G L C C C+ T C C C YVPVCGS+G Y+N C
Sbjct: 54 GLSSHNELLASCGKKFCSRGSRCVLSRKTGEPECQCLEACRPSYVPVCGSDGRFYENHCK 113
Query: 116 LRQAACKQQSEILVVSEGSC 135
L +AAC I V+ C
Sbjct: 114 LHRAACLLGKRITVIHSKDC 133
Score = 40.0 bits (92), Expect = 0.003
Identities = 25/102 (24%), Positives = 46/102 (45%), Gaps = 13/102 (12%)
Query: 138 DAGSGSGDGVHEGSGETSQKE--------TSTCD--ICQFGAEC--DEDAEDVWCVCNID 185
D G G S E +++E ++C C G+ C + C C ++
Sbjct: 33 DVGVGESQAEEPRSFEVTRREGLSSHNELLASCGKKFCSRGSRCVLSRKTGEPECQC-LE 91
Query: 186 CSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRC 227
+ ++ P+C SDG+ Y+N C++ A+C ++I V+ C
Sbjct: 92 ACRPSYVPVCGSDGRFYENHCKLHRAACLLGKRITVIHSKDC 133
>gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens]
Length = 208
Score = 50.1 bits (118), Expect = 3e-06
Identities = 24/79 (30%), Positives = 41/79 (51%), Gaps = 10/79 (12%)
Query: 264 PCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSV---LYVVPGPVRFQYV 320
PC Y FC+HG+C++ ++ PSC C GY G+ C V LY + +
Sbjct: 107 PCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYT------YDHT 160
Query: 321 LIAAVIGTIQIAVICVVVL 339
I AV+ + ++ +C++V+
Sbjct: 161 TILAVVAVV-LSSVCLLVI 178
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 48.9 bits (115), Expect = 7e-06
Identities = 67/305 (21%), Positives = 103/305 (33%), Gaps = 71/305 (23%)
Query: 48 CQTPTGWN---CSGYDDRENDLFLCDTNTCKFDGECLRIGD-TVTCVCQ----------- 92
CQ P G+ C EN C + C+ G C + GD T C C
Sbjct: 183 CQCPAGYTGPLC------ENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVN 236
Query: 93 ------FKCNNDYVPVCGSNGESYQ--------------NECYLRQAACKQQSEILVVSE 132
+C N V G N + Q +EC L+ AC +
Sbjct: 237 VDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACH--------NG 288
Query: 133 GSCATDAGSGSGDGVHEGSGETSQKETSTCD--ICQFGAECDEDAEDVWCVCNIDCSQTN 190
G+C G S V+ +GE+ + C +C GA C + +C C + +T
Sbjct: 289 GTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPM--GKTG 346
Query: 191 FNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYAR--TDYA 248
LC D N C ++A C + ++ C T +D +
Sbjct: 347 L--LCHLDDACVSNPCH-EDAICD-TNPVNGRAICTCPPGFTGGACDQDVDECSIGANPC 402
Query: 249 ENANKLEESAREHHIPCPEHYNG--------FCMHGKCEHSI----NMQEPSCRCDAGYT 296
E+ + + C Y G C+ G C + + + +C C AG+T
Sbjct: 403 EHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFT 462
Query: 297 GQHCE 301
G +CE
Sbjct: 463 GTYCE 467
Score = 37.7 bits (86), Expect = 0.017
Identities = 56/259 (21%), Positives = 82/259 (31%), Gaps = 56/259 (21%)
Query: 48 CQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNG 107
C P G+ G D++ D N C+ G C+ + C +C Y G
Sbjct: 377 CTCPPGFT-GGACDQDVDECSIGANPCEHLGRCVNTQGSFLC----QCGRGYT---GPRC 428
Query: 108 ESYQNECYLRQAACKQQSEILV-VSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDI-- 164
E+ NEC C+ Q+ L + + +C AG +G + + C
Sbjct: 429 ETDVNECL--SGPCRNQATCLDRIGQFTCICMAGF---------TGTYCEVDIDECQSSP 477
Query: 165 CQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSL 224
C G C + C C S + CQ+ C
Sbjct: 478 CVNGGVCKDRVNGFSCTCPSGFS---------------GSTCQLDVDECASTP------- 515
Query: 225 GRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINM 284
C+ N DG+ R + + + P P C HG+C I
Sbjct: 516 --CR-NGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCS-PDP------CHHGRCVDGI-- 563
Query: 285 QEPSCRCDAGYTGQHCEKK 303
SC C GYTG CE +
Sbjct: 564 ASFSCACAPGYTGTRCESQ 582
Score = 36.6 bits (83), Expect = 0.038
Identities = 55/242 (22%), Positives = 80/242 (33%), Gaps = 55/242 (22%)
Query: 63 ENDLFLCDTNTCKFDGECL-RIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAAC 121
E D+ C + C+ CL RIG TC+C Y C + + Q+ + C
Sbjct: 429 ETDVNECLSGPCRNQATCLDRIGQ-FTCICMAGFTGTY---CEVDIDECQSSPCVNGGVC 484
Query: 122 KQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDI--CQFGAECDEDAEDVW 179
K + V+ SC +G SG T Q + C C+ GA+C + +
Sbjct: 485 KDR-----VNGFSCTCPSGF---------SGSTCQLDVDECASTPCRNGAKCVDQPDGYE 530
Query: 180 CVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSED 239
C C T LC N C GRC D + + +
Sbjct: 531 CRCAEGFEGT----LCDR------NVDDCSPDPCHH---------GRCVDGIASFSCACA 571
Query: 240 GHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQH 299
Y T ++ H GKC ++ CRC +G TG +
Sbjct: 572 PGYTGTRCESQVDECRSQPCRHG-------------GKCLDLVDKY--LCRCPSGTTGVN 616
Query: 300 CE 301
CE
Sbjct: 617 CE 618
Score = 33.1 bits (74), Expect = 0.42
Identities = 61/281 (21%), Positives = 86/281 (30%), Gaps = 65/281 (23%)
Query: 48 CQTPTGWN---CSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNN---DYVP 101
C GW+ CS R+ C++ C+ G C G C C + +
Sbjct: 718 CVCEPGWSGPRCSQSLARD----ACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLS 773
Query: 102 VCGSNGESYQNECYLRQAACKQQSEILVVSEG----SCATDAGSGSGD---GVHEGSGET 154
C N + C + Q + +G C D +G G H
Sbjct: 774 PCTPNPCEHGGRC----ESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNL 829
Query: 155 SQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQ 214
+ + TC G CD+D D C NP C + G D SC
Sbjct: 830 AGSFSCTCHGGYTGPSCDQDIND--------CDP---NP-CLNGGSCQDGVGSFS-CSC- 875
Query: 215 KQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGF-- 272
+ + RC + + G TD+ + CP Y GF
Sbjct: 876 ----LPGFAGPRCARDVDECLSNPCGPGTCTDHVASFT----------CTCPPGYGGFHC 921
Query: 273 -----------CMHG-KCEHSINMQEPSCRCDAGYTGQHCE 301
C +G C +N SC C GYTG HC+
Sbjct: 922 EQDLPDCSPSSCFNGGTCVDGVNSF--SCLCRPGYTGAHCQ 960
Score = 29.3 bits (64), Expect = 6.0
Identities = 49/218 (22%), Positives = 64/218 (29%), Gaps = 80/218 (36%)
Query: 48 CQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVC------------QFKC 95
C+ G+N D+ E+D+ C + C+ G C+ + C C + C
Sbjct: 1108 CECLPGYNG---DNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDC 1164
Query: 96 NN----DYVPVCGSNG----------------------ESYQNECYLRQAACKQQSEILV 129
D P C NG E+ NEC R AC
Sbjct: 1165 GPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINEC--RSGACH------A 1216
Query: 130 VSEGSCATDAGSGSGDGVHEG-SGETSQKETSTCDI--CQFGAECDED------------ 174
C D G G H G SG Q S C+ CQ G +C
Sbjct: 1217 AHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCH 1276
Query: 175 -AEDVW---------------CVCNIDCSQTNFNPLCA 196
A+ W C + C QT P CA
Sbjct: 1277 CAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCA 1314
>gi|5901956 follistatin-like 1 precursor [Homo sapiens]
Length = 308
Score = 48.9 bits (115), Expect = 7e-06
Identities = 22/48 (45%), Positives = 29/48 (60%)
Query: 88 TCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSC 135
TC+C +C PVCGSNG++Y N C L + AC S+I V +G C
Sbjct: 51 TCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHC 98
Score = 41.2 bits (95), Expect = 0.002
Identities = 21/71 (29%), Positives = 37/71 (52%), Gaps = 2/71 (2%)
Query: 165 CQFGAECD-EDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMS 223
C G EC + + C+C C + + P+C S+GK+Y N C++ +C KI+V
Sbjct: 36 CGAGRECAVTEKGEPTCLCIEQC-KPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDY 94
Query: 224 LGRCQDNTTTT 234
G C++ + +
Sbjct: 95 DGHCKEKKSVS 105
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 46.6 bits (109), Expect = 4e-05
Identities = 62/270 (22%), Positives = 92/270 (34%), Gaps = 56/270 (20%)
Query: 48 CQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNG 107
C GW D ND C+ D C + + C+C D+ C +
Sbjct: 436 CDCLPGWMGQNCDININDCL----GQCQNDASCRDLVNGYRCICPPGYAGDH---CERDI 488
Query: 108 ESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDI--C 165
+ + L C+ + ++ C G SG Q + C+ C
Sbjct: 489 DECASNPCLNGGHCQNE-----INRFQCLCPTGF---------SGNLCQLDIDYCEPNPC 534
Query: 166 QFGAECDEDAEDVWCVCNIDCSQTNFNPL---CASDGKSYDNACQIKEASCQKQEKIEVM 222
Q GA+C A D +C C D N + L C + ++C + AS E + +
Sbjct: 535 QNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYI 594
Query: 223 SL------GRCQDN-----TTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNG 271
S G+C+ T K G Y EN N E + PC NG
Sbjct: 595 SSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCH----ENINDCESN------PC---RNG 641
Query: 272 FCMHGKCEHSINMQEPSCRCDAGYTGQHCE 301
G C +N + C C G+ G +CE
Sbjct: 642 ----GTCIDGVNSYK--CICSDGWEGAYCE 665
Score = 39.3 bits (90), Expect = 0.006
Identities = 44/200 (22%), Positives = 63/200 (31%), Gaps = 51/200 (25%)
Query: 48 CQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCV---------CQFKCNND 98
C GW R++ CD TC G C GD C+ C N+
Sbjct: 691 CDCKNGWKGKTCHSRDSQ---CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSS 747
Query: 99 YVP-------VCGSNGESYQNECYLRQAACKQ--QSEILVVSEGSCATDAGSGSGDGVHE 149
+P C NGES+ CK+ + I + C+ SG V
Sbjct: 748 CLPNPCHNGGTCVVNGESF-------TCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDG 800
Query: 150 G-----------SGETSQKETSTCDI--CQFGAECDEDAEDVWCVC-----NIDCSQTNF 191
+G + + C C FGA C ++ CVC C + +
Sbjct: 801 DNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSG 860
Query: 192 NPLCA-----SDGKSYDNAC 206
P DG +D+ C
Sbjct: 861 RPCITMGSVIPDGAKWDDDC 880
Score = 29.6 bits (65), Expect = 4.6
Identities = 42/186 (22%), Positives = 60/186 (32%), Gaps = 47/186 (25%)
Query: 130 VSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWCVCNID-CSQ 188
++E +C +D G S KETS F EC C NID CS
Sbjct: 335 IAEHACLSDPCHNRG----------SCKETSL----GFECECSPGWTGPTCSTNIDDCSP 380
Query: 189 TNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYA 248
N C+ G D K C T T D +
Sbjct: 381 NN----CSHGGTCQDLVNGFKCV---------------CPPQWTGKTCQLDANECEAKPC 421
Query: 249 ENANKLEESAREHHIPCPEHYNGF--------CMHGKCEHSINMQEP----SCRCDAGYT 296
NA + ++ C + G C+ G+C++ + ++ C C GY
Sbjct: 422 VNAKSCKNLIASYYCDCLPGWMGQNCDININDCL-GQCQNDASCRDLVNGYRCICPPGYA 480
Query: 297 GQHCEK 302
G HCE+
Sbjct: 481 GDHCER 486
Score = 29.3 bits (64), Expect = 6.0
Identities = 17/56 (30%), Positives = 24/56 (42%), Gaps = 15/56 (26%)
Query: 262 HIPCPEHYNGFCMHG----KCEHSINMQEPS-----------CRCDAGYTGQHCEK 302
H C ++ N CM G +C +I Q S CRC G+ G +C+K
Sbjct: 209 HYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDK 264
>gi|24308277 SPARC related modular calcium binding 2 [Homo sapiens]
Length = 457
Score = 46.6 bits (109), Expect = 4e-05
Identities = 18/48 (37%), Positives = 32/48 (66%), Gaps = 1/48 (2%)
Query: 182 CNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQD 229
C++DC+ + PLCASDG+++ + C+ + A C K ++E+ G C+D
Sbjct: 40 CSLDCAGSPQKPLCASDGRTFLSRCEFQRAKC-KDPQLEIAYRGNCKD 86
Score = 29.6 bits (65), Expect = 4.6
Identities = 14/56 (25%), Positives = 27/56 (48%), Gaps = 2/56 (3%)
Query: 81 LRIGDTVTCVCQFKC-NNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSC 135
LR+ C C + P+C S+G ++ + C ++A CK ++ + G+C
Sbjct: 30 LRVDQDKDKDCSLDCAGSPQKPLCASDGRTFLSRCEFQRAKCK-DPQLEIAYRGNC 84
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 45.8 bits (107), Expect = 6e-05
Identities = 57/258 (22%), Positives = 92/258 (35%), Gaps = 61/258 (23%)
Query: 52 TGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQ 111
TG NC E +L C + C DG C+ + TC C+ G++ E+
Sbjct: 997 TGINC------EINLDECLSEPCLHDGVCIDGINHYTCDCKSG-------FFGTHCETNA 1043
Query: 112 NECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDI--CQFGA 169
N+C + +E+ ++E C+ DA +G+ + + + C C
Sbjct: 1044 NDCLSNPCLHGRCTEL--INEYPCSCDA---------DGTSTQCKIKINDCTSIPCMNEG 1092
Query: 170 ECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNA-CQIKEASCQKQEKIEVMSL--GR 226
C + A C+C + Y A C+ +C + E V+ L G
Sbjct: 1093 FCQKSAHGFTCICP----------------RGYTGAYCEKSIDNCAEPELNSVICLNGGI 1136
Query: 227 CQDNTTTTTKSEDGHYARTDYAE-NANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQ 285
C D T + E N N+ S H C +H NG+
Sbjct: 1137 CVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYV------------ 1184
Query: 286 EPSCRCDAGYTGQHCEKK 303
C+C G++G HCE +
Sbjct: 1185 ---CKCQPGWSGHHCENE 1199
Score = 38.9 bits (89), Expect = 0.008
Identities = 46/173 (26%), Positives = 69/173 (39%), Gaps = 28/173 (16%)
Query: 48 CQTP-TGWNCSGYDDRENDLFLCDTNTCKFDGECLRI-GDTVTCVCQFKCNNDYVPVCGS 105
C P TG NCS + C + C F G C I ++ C C + + P C
Sbjct: 244 CHPPFTGKNCSEIIGQ------CQPHVC-FHGNCSNITSNSFICECDEQFSG---PFCEV 293
Query: 106 NGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDIC 165
+ + + + ++ C S S + GS S +G ET E S C
Sbjct: 294 SAKPCVSLLFWKRGICPNSS-----SAYTYECPKGSSSQNG------ETDVSEFSLVP-C 341
Query: 166 QFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEK 218
Q G +C + + DV C+ CS + LC S S ++ A+C+K EK
Sbjct: 342 QNGTDCIKISNDVMCI----CSPIFTDLLCKSIQTSCESFPLRNNATCKKCEK 390
Score = 38.9 bits (89), Expect = 0.008
Identities = 58/259 (22%), Positives = 93/259 (35%), Gaps = 57/259 (22%)
Query: 69 CDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEIL 128
C + CK +G C+ + + C C+ + + P C E N+C + + C + +
Sbjct: 932 CSSEPCKNNGTCVDLTNRFFCNCEPEYHG---PFC----ELDVNKCKI--SPCLDEENCV 982
Query: 129 VVSEG-SCATDAGSG------------SGDGVHEG-SGETSQKETSTCDICQFGAECDED 174
++G +C G S +H+G + T C FG C+ +
Sbjct: 983 YRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETN 1042
Query: 175 AEDVWCVCNI----DCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDN 230
A D C+ N C++ C+ D C+IK C I M+ G CQ +
Sbjct: 1043 AND--CLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDC---TSIPCMNEGFCQKS 1097
Query: 231 ----TTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQE 286
T + G Y A PE + C++G I +
Sbjct: 1098 AHGFTCICPRGYTGAYCEKSIDNCAE-------------PELNSVICLNG----GICVDG 1140
Query: 287 P----SCRCDAGYTGQHCE 301
P CRC G++GQ CE
Sbjct: 1141 PGHTFDCRCLPGFSGQFCE 1159
Score = 38.5 bits (88), Expect = 0.010
Identities = 39/167 (23%), Positives = 61/167 (36%), Gaps = 20/167 (11%)
Query: 162 CDICQFGAECDEDAEDVW---CVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEK 218
C+ G C++D +D C N C + + C N C+ + C+
Sbjct: 721 CNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECK---- 776
Query: 219 IEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKC 278
+ C++N+T T + T N EE PC NG G C
Sbjct: 777 -----MNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPC---MNG----GLC 824
Query: 279 EHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAV 325
S + C C YTGQ C ++ Y++ ++ P R +A V
Sbjct: 825 HESTIPGQFVCLCPPLYTGQFCHQR-YNLCDLLHNPCRNNSTCLALV 870
Score = 33.1 bits (74), Expect = 0.42
Identities = 38/147 (25%), Positives = 56/147 (38%), Gaps = 16/147 (10%)
Query: 159 TSTCDICQFGAECDEDAEDVWC-VCNIDCSQTNF--NPLCASDGKSYDNACQIKEASCQK 215
TS IC ECDE +C V C F +C + +Y C +S
Sbjct: 274 TSNSFIC----ECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNG 329
Query: 216 QEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMH 275
+ + SL CQ+ T S D + + L +S + P N C
Sbjct: 330 ETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDL--LCKSIQTSCESFPLRNNATCK- 386
Query: 276 GKCEHSINMQEPSCRCDAGYTGQHCEK 302
KCE ++ C C +G+T ++CEK
Sbjct: 387 -KCE-----KDYPCSCISGFTEKNCEK 407
Score = 30.0 bits (66), Expect = 3.5
Identities = 17/53 (32%), Positives = 23/53 (43%), Gaps = 4/53 (7%)
Query: 69 CDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAAC 121
C NTC+ GEC G T +C +C D+ + S N L Q+ C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSC----RCLPDWAGNTCNQSVSCLNNLCLHQSLC 2927
Score = 29.6 bits (65), Expect = 4.6
Identities = 12/34 (35%), Positives = 19/34 (55%), Gaps = 1/34 (2%)
Query: 272 FCM-HGKCEHSINMQEPSCRCDAGYTGQHCEKKD 304
FC HGKC + SC C ++G++C++ D
Sbjct: 182 FCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELD 215
Score = 29.6 bits (65), Expect = 4.6
Identities = 57/289 (19%), Positives = 93/289 (32%), Gaps = 67/289 (23%)
Query: 63 ENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACK 122
E D+ C N C+ + C + + CVC ++ E NEC + CK
Sbjct: 731 EQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFC-------EQESNEC--KMNPCK 781
Query: 123 QQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDI--CQFGAECDEDAEDVWC 180
S +C S + +G+ +E + CD C G C E
Sbjct: 782 NNS--------TCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQF 833
Query: 181 VC---------------------------NIDC---SQTNFNPLCASDGKSYDNACQIKE 210
VC N C N + +C + + + +K+
Sbjct: 834 VCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKD 893
Query: 211 A---SCQKQEKIEVMSLG---RCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIP 264
SCQ E M C+ + + + + ++ +N +
Sbjct: 894 CLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCN 953
Query: 265 C-PEHYNGFCM--HGKCEHSINMQEP---------SCRCDAGYTGQHCE 301
C PE++ FC KC+ S + E +C C GYTG +CE
Sbjct: 954 CEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCE 1002
Score = 28.9 bits (63), Expect = 7.8
Identities = 29/149 (19%), Positives = 58/149 (38%), Gaps = 39/149 (26%)
Query: 165 CQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSL 224
C+ GA C + + +C C P DG + C + ++ I+ L
Sbjct: 690 CKNGATCIDQPGNYFCQC--------VPPFKVVDG--FSCLCNPGYVGIRCEQDIDDCIL 739
Query: 225 GRCQDNTTTTTKSEDGHYAR-----TDYAEN-----ANKLEESAREHHIPCPEHYNGFCM 274
C+ N+T +D H + +D+ N +N+ + + +++ C + Y +
Sbjct: 740 NACEHNSTC----KDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSY-- 793
Query: 275 HGKCEHSINMQEPSCRCDAGYTGQHCEKK 303
C C +G+TGQ+C ++
Sbjct: 794 -------------RCECTSGWTGQNCSEE 809
>gi|61806622 epithelial mitogen [Homo sapiens]
Length = 133
Score = 45.8 bits (107), Expect = 6e-05
Identities = 25/87 (28%), Positives = 43/87 (49%), Gaps = 4/87 (4%)
Query: 265 CPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAA 324
C E +N +C++G C +++ CRC GYTG+ CE + Y V + Y+ I
Sbjct: 51 CLEDHNSYCINGACAFHHELEKAICRCFTGYTGERCEHLTLT-SYAVDSYEK--YIAIGI 107
Query: 325 VIGTIQIAVICVVVLCITRKCPRSNRI 351
+G + ++ V+ C RK ++I
Sbjct: 108 GVGLL-LSGFLVIFYCYIRKRYEKDKI 133
>gi|74027261 serine peptidase inhibitor, Kazal type 5 isoform b
precursor [Homo sapiens]
Length = 1064
Score = 45.1 bits (105), Expect = 1e-04
Identities = 30/141 (21%), Positives = 58/141 (41%), Gaps = 16/141 (11%)
Query: 95 CNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGET 154
C + PV G++G+ Y N+CY+ +A ++ + + S D S
Sbjct: 930 CPRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLD 989
Query: 155 SQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQ 214
S+ + + G C +D P+C DG++Y+N C + +
Sbjct: 990 SEMCKDYRVLPRIGYLCPKD----------------LKPVCGDDGQTYNNPCMLCHENLI 1033
Query: 215 KQEKIEVMSLGRCQDNTTTTT 235
+Q + S G+C++++T T
Sbjct: 1034 RQTNTHIRSTGKCEESSTPGT 1054
Score = 44.3 bits (103), Expect = 2e-04
Identities = 37/131 (28%), Positives = 55/131 (41%), Gaps = 34/131 (25%)
Query: 93 FKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSG 152
F C + Y VCG++G++Y N C L K S+I V SEG C
Sbjct: 109 FICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGEC----------------- 151
Query: 153 ETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQ----- 207
++S E D+C D + C++ N +P+ DGK++ N C
Sbjct: 152 KSSNPEQ---DVCSAFRPFVRDG-------RLGCTREN-DPVLGPDGKTHGNKCAMCAEL 200
Query: 208 -IKEASCQKQE 217
+KEA K+E
Sbjct: 201 FLKEAENAKRE 211
Score = 40.4 bits (93), Expect = 0.003
Identities = 25/95 (26%), Positives = 39/95 (41%), Gaps = 8/95 (8%)
Query: 49 QTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGE 108
+ P+ S +D + D+ CK RIG + C D PVCG +G+
Sbjct: 968 EKPSHVRASQEEDSPDSFSSLDSEMCKDYRVLPRIG--------YLCPKDLKPVCGDDGQ 1019
Query: 109 SYQNECYLRQAACKQQSEILVVSEGSCATDAGSGS 143
+Y N C L +Q+ + S G C + G+
Sbjct: 1020 TYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGT 1054
Score = 37.4 bits (85), Expect = 0.022
Identities = 37/169 (21%), Positives = 72/169 (42%), Gaps = 35/169 (20%)
Query: 92 QFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGS 151
+ C + PV ++G+SY N+C + +A ++++E +E S + G+GS G
Sbjct: 718 RLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAE--RKNEYSRSRSNGTGSESG----- 770
Query: 152 GETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEA 211
TCD E ++ +C + +P+ DGK++ N C +
Sbjct: 771 -------KDTCD------EFRSQMKNGKLICTRES-----DPVRGPDGKTHGNKCTM--- 809
Query: 212 SCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESARE 260
C+++ + E + +D + T R++ E +N E+ RE
Sbjct: 810 -CKEKLEREAAEKKKKEDEDRSNTGE------RSNTGERSNDKEDLCRE 851
Score = 35.4 bits (80), Expect = 0.084
Identities = 38/171 (22%), Positives = 71/171 (41%), Gaps = 28/171 (16%)
Query: 95 CNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGET 154
C + PV G +G + N+C L KQ+ SE + TD + G+
Sbjct: 239 CTRESDPVRGPDGRMHGNKCALCAEIFKQR-----FSEENSKTD----------QNLGKA 283
Query: 155 SQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQ 214
+K +I + ++ A++ + C++ N +P+ DGK + N C + +A Q
Sbjct: 284 EEKTKVKREIVKLCSQYQNQAKN----GILFCTREN-DPIRGPDGKMHGNLCSMCQAYFQ 338
Query: 215 KQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPC 265
+ + + + R ++ K E G T YAE ++ + R + C
Sbjct: 339 AENEEKKKAEARARN------KRESG--KATSYAELCSEYRKLVRNGKLAC 381
Score = 34.3 bits (77), Expect = 0.19
Identities = 13/40 (32%), Positives = 23/40 (57%)
Query: 191 FNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDN 230
+ +C +DGK+YDN C + + + +I V S G C+ +
Sbjct: 115 YEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSS 154
Score = 33.5 bits (75), Expect = 0.32
Identities = 33/155 (21%), Positives = 62/155 (40%), Gaps = 26/155 (16%)
Query: 95 CNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGET 154
C + P+ G +G+ + N C + QA + ++E +E SG
Sbjct: 311 CTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESG------------ 358
Query: 155 SQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQ 214
K TS ++C + + + + C++ N +P+ DGK + N C + E Q
Sbjct: 359 --KATSYAELCSEYRKLVRNGK-------LACTREN-DPIQGPDGKVHGNTCSMCEVFFQ 408
Query: 215 KQE----KIEVMSLGRCQDNTTTTTKSEDGHYART 245
+E K E S + Q +T + + Y ++
Sbjct: 409 AEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKS 443
Score = 29.6 bits (65), Expect = 4.6
Identities = 25/124 (20%), Positives = 46/124 (37%), Gaps = 22/124 (17%)
Query: 95 CNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGET 154
C + P+ G +G+ + N C + + + + E EG S S E E
Sbjct: 381 CTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEY 440
Query: 155 SQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQ 214
+ + + C++ N +P+ DGK + N C + EA Q
Sbjct: 441 RKSRKNG---------------------RLFCTREN-DPIQGPDGKMHGNTCSMCEAFFQ 478
Query: 215 KQEK 218
++E+
Sbjct: 479 QEER 482
>gi|189163501 serine peptidase inhibitor, Kazal type 5 isoform a
precursor [Homo sapiens]
Length = 1094
Score = 45.1 bits (105), Expect = 1e-04
Identities = 30/141 (21%), Positives = 58/141 (41%), Gaps = 16/141 (11%)
Query: 95 CNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGET 154
C + PV G++G+ Y N+CY+ +A ++ + + S D S
Sbjct: 960 CPRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLD 1019
Query: 155 SQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQ 214
S+ + + G C +D P+C DG++Y+N C + +
Sbjct: 1020 SEMCKDYRVLPRIGYLCPKD----------------LKPVCGDDGQTYNNPCMLCHENLI 1063
Query: 215 KQEKIEVMSLGRCQDNTTTTT 235
+Q + S G+C++++T T
Sbjct: 1064 RQTNTHIRSTGKCEESSTPGT 1084
Score = 44.3 bits (103), Expect = 2e-04
Identities = 37/131 (28%), Positives = 55/131 (41%), Gaps = 34/131 (25%)
Query: 93 FKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSG 152
F C + Y VCG++G++Y N C L K S+I V SEG C
Sbjct: 109 FICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGEC----------------- 151
Query: 153 ETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQ----- 207
++S E D+C D + C++ N +P+ DGK++ N C
Sbjct: 152 KSSNPEQ---DVCSAFRPFVRDG-------RLGCTREN-DPVLGPDGKTHGNKCAMCAEL 200
Query: 208 -IKEASCQKQE 217
+KEA K+E
Sbjct: 201 FLKEAENAKRE 211
Score = 40.4 bits (93), Expect = 0.003
Identities = 25/95 (26%), Positives = 39/95 (41%), Gaps = 8/95 (8%)
Query: 49 QTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGE 108
+ P+ S +D + D+ CK RIG + C D PVCG +G+
Sbjct: 998 EKPSHVRASQEEDSPDSFSSLDSEMCKDYRVLPRIG--------YLCPKDLKPVCGDDGQ 1049
Query: 109 SYQNECYLRQAACKQQSEILVVSEGSCATDAGSGS 143
+Y N C L +Q+ + S G C + G+
Sbjct: 1050 TYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGT 1084
Score = 37.4 bits (85), Expect = 0.022
Identities = 37/169 (21%), Positives = 72/169 (42%), Gaps = 35/169 (20%)
Query: 92 QFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGS 151
+ C + PV ++G+SY N+C + +A ++++E +E S + G+GS G
Sbjct: 718 RLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAE--RKNEYSRSRSNGTGSESG----- 770
Query: 152 GETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEA 211
TCD E ++ +C + +P+ DGK++ N C +
Sbjct: 771 -------KDTCD------EFRSQMKNGKLICTRES-----DPVRGPDGKTHGNKCTM--- 809
Query: 212 SCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESARE 260
C+++ + E + +D + T R++ E +N E+ RE
Sbjct: 810 -CKEKLEREAAEKKKKEDEDRSNTGE------RSNTGERSNDKEDLCRE 851
Score = 35.4 bits (80), Expect = 0.084
Identities = 38/171 (22%), Positives = 71/171 (41%), Gaps = 28/171 (16%)
Query: 95 CNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGET 154
C + PV G +G + N+C L KQ+ SE + TD + G+
Sbjct: 239 CTRESDPVRGPDGRMHGNKCALCAEIFKQR-----FSEENSKTD----------QNLGKA 283
Query: 155 SQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQ 214
+K +I + ++ A++ + C++ N +P+ DGK + N C + +A Q
Sbjct: 284 EEKTKVKREIVKLCSQYQNQAKN----GILFCTREN-DPIRGPDGKMHGNLCSMCQAYFQ 338
Query: 215 KQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPC 265
+ + + + R ++ K E G T YAE ++ + R + C
Sbjct: 339 AENEEKKKAEARARN------KRESG--KATSYAELCSEYRKLVRNGKLAC 381
Score = 34.3 bits (77), Expect = 0.19
Identities = 13/40 (32%), Positives = 23/40 (57%)
Query: 191 FNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDN 230
+ +C +DGK+YDN C + + + +I V S G C+ +
Sbjct: 115 YEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSS 154
Score = 33.5 bits (75), Expect = 0.32
Identities = 33/155 (21%), Positives = 62/155 (40%), Gaps = 26/155 (16%)
Query: 95 CNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGET 154
C + P+ G +G+ + N C + QA + ++E +E SG
Sbjct: 311 CTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESG------------ 358
Query: 155 SQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQ 214
K TS ++C + + + + C++ N +P+ DGK + N C + E Q
Sbjct: 359 --KATSYAELCSEYRKLVRNGK-------LACTREN-DPIQGPDGKVHGNTCSMCEVFFQ 408
Query: 215 KQE----KIEVMSLGRCQDNTTTTTKSEDGHYART 245
+E K E S + Q +T + + Y ++
Sbjct: 409 AEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKS 443
Score = 29.6 bits (65), Expect = 4.6
Identities = 25/124 (20%), Positives = 46/124 (37%), Gaps = 22/124 (17%)
Query: 95 CNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGET 154
C + P+ G +G+ + N C + + + + E EG S S E E
Sbjct: 381 CTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEY 440
Query: 155 SQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQ 214
+ + + C++ N +P+ DGK + N C + EA Q
Sbjct: 441 RKSRKNG---------------------RLFCTREN-DPIQGPDGKMHGNTCSMCEAFFQ 478
Query: 215 KQEK 218
++E+
Sbjct: 479 QEER 482
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,684,605
Number of Sequences: 37866
Number of extensions: 814501
Number of successful extensions: 3403
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 93
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 2445
Number of HSP's gapped (non-prelim): 897
length of query: 374
length of database: 18,247,518
effective HSP length: 104
effective length of query: 270
effective length of database: 14,309,454
effective search space: 3863552580
effective search space used: 3863552580
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.