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Search of human proteins with 122937516
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122937516 aldo-keto reductase family 1, member B10-like
[Homo sapiens]
(316 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122937516 aldo-keto reductase family 1, member B10-like [Homo... 649 0.0
gi|223468663 aldo-keto reductase family 1, member B10 [Homo sapi... 594 e-170
gi|4502049 aldo-keto reductase family 1, member B1 [Homo sapiens] 451 e-127
gi|93277124 aldo-keto reductase family 1, member C-like 2 [Homo ... 334 5e-92
gi|5174695 aldo-keto reductase family 1, member D1 [Homo sapiens] 306 2e-83
gi|24497577 aldo-keto reductase family 1, member A1 [Homo sapiens] 301 4e-82
gi|5174391 aldo-keto reductase family 1, member A1 [Homo sapiens] 301 4e-82
gi|45446745 aldo-keto reductase family 1, member C2 [Homo sapiens] 294 8e-80
gi|4503285 aldo-keto reductase family 1, member C2 [Homo sapiens] 294 8e-80
gi|5453543 aldo-keto reductase family 1, member C1 [Homo sapiens] 292 3e-79
gi|24497585 aldo-keto reductase family 1, member C4 [Homo sapiens] 288 6e-78
gi|24497583 aldo-keto reductase family 1, member C3 [Homo sapiens] 286 2e-77
gi|207028673 hypothetical protein LOC100134257 [Homo sapiens] 100 1e-21
gi|27436964 potassium voltage-gated channel, shaker-related subf... 37 0.030
gi|27436962 potassium voltage-gated channel, shaker-related subf... 37 0.030
gi|27436966 potassium voltage-gated channel, shaker-related subf... 37 0.030
gi|149944410 hypothetical protein LOC57587 [Homo sapiens] 32 0.96
gi|4504011 glutamate-cysteine ligase regulatory protein [Homo sa... 30 2.1
gi|55749998 deiodinase, iodothyronine, type II isoform b [Homo s... 28 8.2
gi|42822880 beta-lactamase-like [Homo sapiens] 28 8.2
gi|122937514 unc-13 homolog C [Homo sapiens] 28 8.2
>gi|122937516 aldo-keto reductase family 1, member B10-like [Homo
sapiens]
Length = 316
Score = 649 bits (1673), Expect = 0.0
Identities = 316/316 (100%), Positives = 316/316 (100%)
Query: 1 MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQ 60
MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQ
Sbjct: 1 MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQ 60
Query: 61 EKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD 120
EKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD
Sbjct: 61 EKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD 120
Query: 121 DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKP 180
DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKP
Sbjct: 121 DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKP 180
Query: 181 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK 240
VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK
Sbjct: 181 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK 240
Query: 241 HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFD 300
HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFD
Sbjct: 241 HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFD 300
Query: 301 FKEFSHLEDFPFDAEY 316
FKEFSHLEDFPFDAEY
Sbjct: 301 FKEFSHLEDFPFDAEY 316
>gi|223468663 aldo-keto reductase family 1, member B10 [Homo
sapiens]
Length = 316
Score = 594 bits (1531), Expect = e-170
Identities = 289/316 (91%), Positives = 301/316 (95%)
Query: 1 MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQ 60
MATFVELSTKAKMPIVGLGTW+S LGKVKEAVKVAIDA YRHIDCAY Y+N+HEVGEAIQ
Sbjct: 1 MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQ 60
Query: 61 EKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD 120
EKIQEKAV REDLFIVSK+WPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFK+GD
Sbjct: 61 EKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD 120
Query: 121 DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKP 180
D FPKDDKGN I GK TFLDAWEAMEELVDEGLVKALGVSNF+HFQIE+LLNKPGLKYKP
Sbjct: 121 DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP 180
Query: 181 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK 240
VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK
Sbjct: 181 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK 240
Query: 241 HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFD 300
HKKT AQVLIRFHIQRNV VIPKS+TPA IVENIQVFDFKLSDEEMATILSFNRNWRA +
Sbjct: 241 HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN 300
Query: 301 FKEFSHLEDFPFDAEY 316
+ SHLED+PF+AEY
Sbjct: 301 VLQSSHLEDYPFNAEY 316
>gi|4502049 aldo-keto reductase family 1, member B1 [Homo sapiens]
Length = 316
Score = 451 bits (1161), Expect = e-127
Identities = 213/316 (67%), Positives = 256/316 (81%)
Query: 1 MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQ 60
MA+ + L+ AKMPI+GLGTW+S G+V EAVKVAID YRHIDCA+ Y+N++EVG AIQ
Sbjct: 1 MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ 60
Query: 61 EKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD 120
EK++E+ V RE+LFIVSK+W T+ E+ LV+ A +KTL DLKL YLD+YLIHWP GFK G
Sbjct: 61 EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK 120
Query: 121 DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKP 180
+FFP D+ GN++ LD W AMEELVDEGLVKA+G+SNFNH Q+E +LNKPGLKYKP
Sbjct: 121 EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP 180
Query: 181 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK 240
NQ+ECHPYLTQEKLIQYC SKGI VTAYSPLGSPDRPWAKPEDPSLLEDP+IK IAAK
Sbjct: 181 AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK 240
Query: 241 HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFD 300
H KTTAQVLIRF +QRN+ VIPKS+TP I EN +VFDF+LS ++M T+LS+NRNWR
Sbjct: 241 HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA 300
Query: 301 FKEFSHLEDFPFDAEY 316
+ +D+PF E+
Sbjct: 301 LLSCTSHKDYPFHEEF 316
>gi|93277124 aldo-keto reductase family 1, member C-like 2 [Homo
sapiens]
Length = 320
Score = 334 bits (857), Expect = 5e-92
Identities = 174/323 (53%), Positives = 216/323 (66%), Gaps = 25/323 (7%)
Query: 13 MPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQEKIQEKAVMRED 72
+P VGL +W++ GKV EAVK AIDA YRH DCAYFY N+ EVG I+ KI+E AV RED
Sbjct: 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRRED 63
Query: 73 LFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD------------ 120
LFI +K+W T ++ LV A K+LK LKL+YLD+YLIHWP GFK
Sbjct: 64 LFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCSELSF 123
Query: 121 -------DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNK 173
P D+ +I FLD WEAME+LV GLVK +GVSNFNH Q+ERLLNK
Sbjct: 124 CLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNK 183
Query: 174 PGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPK 233
PGL++KP+TNQ+ECHPYLTQ+ LI +C S+ ++VTAY PLG E L+++P
Sbjct: 184 PGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLG------GSCEGVDLIDNPV 237
Query: 234 IKEIAAKHKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFN 293
IK IA +H K+ AQ+LIRF IQRNV VIP S+TP+HI ENIQVFDF+L+ +M ILS N
Sbjct: 238 IKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLN 297
Query: 294 RNWRAFDFKEFSHLEDFPFDAEY 316
RN R F + +D+PF EY
Sbjct: 298 RNLRLAMFPITKNHKDYPFHIEY 320
>gi|5174695 aldo-keto reductase family 1, member D1 [Homo sapiens]
Length = 326
Score = 306 bits (784), Expect = 2e-83
Identities = 154/317 (48%), Positives = 203/317 (64%), Gaps = 5/317 (1%)
Query: 5 VELSTKAKMPIVGLGTWRSLLGKVKEA----VKVAIDAEYRHIDCAYFYENQHEVGEAIQ 60
+ LS +PI+GLGT+ K A VKVAID YRHID AY Y+N+HEVGEAI+
Sbjct: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69
Query: 61 EKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD 120
EKI E V RED+F K+W T +VR E+TL+ L+L Y+D+Y+I P FK GD
Sbjct: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129
Query: 121 DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKP 180
+ +P+D+ G + K WEAME D GLVK+LGVSNFN Q+E +LNKPGLK+KP
Sbjct: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189
Query: 181 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRP-WAKPEDPSLLEDPKIKEIAA 239
V+NQVECHPY TQ KL+++C I +TAYSPLG+ P W P LL+D + +
Sbjct: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249
Query: 240 KHKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAF 299
++ KT AQ+++RF+IQR V VIPKS I EN Q+FDF L++EEM I + N+N R
Sbjct: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309
Query: 300 DFKEFSHLEDFPFDAEY 316
+ + ++PF EY
Sbjct: 310 ELLMWRDHPEYPFHDEY 326
>gi|24497577 aldo-keto reductase family 1, member A1 [Homo sapiens]
Length = 325
Score = 301 bits (772), Expect = 4e-82
Identities = 148/297 (49%), Positives = 206/297 (69%), Gaps = 3/297 (1%)
Query: 2 ATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQE 61
A+ V L T KMP++GLGTW+S G+VK AVK A+ YRHIDCA Y N+ E+GEA++E
Sbjct: 3 ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62
Query: 62 KIQE-KAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD 120
+ KAV RE+LF+ SK+W T V A KTL DL+L YLD+YL+HWP F+ GD
Sbjct: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122
Query: 121 DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKP 180
+ FPK+ G + + + W+A+E LV +GLV+ALG+SNFN QI+ +L+ ++ P
Sbjct: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--P 180
Query: 181 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK 240
QVECHPYL Q +LI +C ++G+ VTAYSPLGS DR W P++P LLE+P + +A K
Sbjct: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240
Query: 241 HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWR 297
+ ++ AQ+L+R+ +QR V IPKS+TP+ I++NI+VFDF S EEM + + N+NWR
Sbjct: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWR 297
>gi|5174391 aldo-keto reductase family 1, member A1 [Homo sapiens]
Length = 325
Score = 301 bits (772), Expect = 4e-82
Identities = 148/297 (49%), Positives = 206/297 (69%), Gaps = 3/297 (1%)
Query: 2 ATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQE 61
A+ V L T KMP++GLGTW+S G+VK AVK A+ YRHIDCA Y N+ E+GEA++E
Sbjct: 3 ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62
Query: 62 KIQE-KAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD 120
+ KAV RE+LF+ SK+W T V A KTL DL+L YLD+YL+HWP F+ GD
Sbjct: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122
Query: 121 DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKP 180
+ FPK+ G + + + W+A+E LV +GLV+ALG+SNFN QI+ +L+ ++ P
Sbjct: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--P 180
Query: 181 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK 240
QVECHPYL Q +LI +C ++G+ VTAYSPLGS DR W P++P LLE+P + +A K
Sbjct: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240
Query: 241 HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWR 297
+ ++ AQ+L+R+ +QR V IPKS+TP+ I++NI+VFDF S EEM + + N+NWR
Sbjct: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWR 297
>gi|45446745 aldo-keto reductase family 1, member C2 [Homo sapiens]
Length = 323
Score = 294 bits (752), Expect = 8e-80
Identities = 148/316 (46%), Positives = 201/316 (63%), Gaps = 4/316 (1%)
Query: 5 VELSTKAKMPIVGLGTWRSL---LGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQE 61
V+L+ MP++G GT+ K EAVK+AI+A + HID A+ Y N+ +VG AI+
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRS 67
Query: 62 KIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGDD 121
KI + +V RED+F SK+W LVR A E++LK+L+L Y+D+YLIH+P K G++
Sbjct: 68 KIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEE 127
Query: 122 FFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKPV 181
PKD+ G ++ WEAME+ D GL K++GVSNFNH +E +LNKPGLKYKPV
Sbjct: 128 VIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPV 187
Query: 182 TNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGS-PDRPWAKPEDPSLLEDPKIKEIAAK 240
NQVECHPY Q KL+ +C SK I + AYS LGS + PW P P LLEDP + +A K
Sbjct: 188 CNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKK 247
Query: 241 HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFD 300
HK+T A + +R+ +QR V V+ KS I +N+QVF+F+L+ EEM I NRN R
Sbjct: 248 HKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLT 307
Query: 301 FKEFSHLEDFPFDAEY 316
F+ ++PF EY
Sbjct: 308 LDIFAGPPNYPFSDEY 323
>gi|4503285 aldo-keto reductase family 1, member C2 [Homo sapiens]
Length = 323
Score = 294 bits (752), Expect = 8e-80
Identities = 148/316 (46%), Positives = 201/316 (63%), Gaps = 4/316 (1%)
Query: 5 VELSTKAKMPIVGLGTWRSL---LGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQE 61
V+L+ MP++G GT+ K EAVK+AI+A + HID A+ Y N+ +VG AI+
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRS 67
Query: 62 KIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGDD 121
KI + +V RED+F SK+W LVR A E++LK+L+L Y+D+YLIH+P K G++
Sbjct: 68 KIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEE 127
Query: 122 FFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKPV 181
PKD+ G ++ WEAME+ D GL K++GVSNFNH +E +LNKPGLKYKPV
Sbjct: 128 VIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPV 187
Query: 182 TNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGS-PDRPWAKPEDPSLLEDPKIKEIAAK 240
NQVECHPY Q KL+ +C SK I + AYS LGS + PW P P LLEDP + +A K
Sbjct: 188 CNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKK 247
Query: 241 HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFD 300
HK+T A + +R+ +QR V V+ KS I +N+QVF+F+L+ EEM I NRN R
Sbjct: 248 HKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLT 307
Query: 301 FKEFSHLEDFPFDAEY 316
F+ ++PF EY
Sbjct: 308 LDIFAGPPNYPFSDEY 323
>gi|5453543 aldo-keto reductase family 1, member C1 [Homo sapiens]
Length = 323
Score = 292 bits (747), Expect = 3e-79
Identities = 147/316 (46%), Positives = 201/316 (63%), Gaps = 4/316 (1%)
Query: 5 VELSTKAKMPIVGLGTWRSL---LGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQE 61
V+L+ MP++G GT+ K EA K+AI+A +RHID A+ Y N+ +VG AI+
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRS 67
Query: 62 KIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGDD 121
KI + +V RED+F SK+W LVR A E++LK+L+L Y+D+YLIH+P K G++
Sbjct: 68 KIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEE 127
Query: 122 FFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKPV 181
PKD+ G ++ WEA+E+ D GL K++GVSNFN Q+E +LNKPGLKYKPV
Sbjct: 128 VIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPV 187
Query: 182 TNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGS-PDRPWAKPEDPSLLEDPKIKEIAAK 240
NQVECHPY Q KL+ +C SK I + AYS LGS + PW P P LLEDP + +A K
Sbjct: 188 CNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKK 247
Query: 241 HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFD 300
HK+T A + +R+ +QR V V+ KS I +N+QVF+F+L+ EEM I NRN R
Sbjct: 248 HKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLT 307
Query: 301 FKEFSHLEDFPFDAEY 316
F+ ++PF EY
Sbjct: 308 LDIFAGPPNYPFSDEY 323
>gi|24497585 aldo-keto reductase family 1, member C4 [Homo sapiens]
Length = 323
Score = 288 bits (736), Expect = 6e-78
Identities = 146/316 (46%), Positives = 199/316 (62%), Gaps = 4/316 (1%)
Query: 5 VELSTKAKMPIVGLGTWRSL---LGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQE 61
VEL+ MP++G GT+ + E K+AI+A +RHID AY Y N+ +VG AI+
Sbjct: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67
Query: 62 KIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGDD 121
KI + +V RED+F SK+W TFF+ +V+ A E +LK L+L Y+D+YL+H+P K G+
Sbjct: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127
Query: 122 FFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKPV 181
PKD+ G +I WE ME+ D GL K++GVSNFN Q+E +LNKPGLKYKPV
Sbjct: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPV 187
Query: 182 TNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSP-DRPWAKPEDPSLLEDPKIKEIAAK 240
NQVECHPYL Q KL+ +C SK I + A+S LG+ + W P P LLEDP + +A K
Sbjct: 188 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 247
Query: 241 HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFD 300
HK+T A + +R+ +QR V V+ KS I ENIQVF+F+L+ E+M + NRN+R
Sbjct: 248 HKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVV 307
Query: 301 FKEFSHLEDFPFDAEY 316
D+PF EY
Sbjct: 308 MDFLMDHPDYPFSDEY 323
>gi|24497583 aldo-keto reductase family 1, member C3 [Homo sapiens]
Length = 323
Score = 286 bits (731), Expect = 2e-77
Identities = 144/316 (45%), Positives = 198/316 (62%), Gaps = 4/316 (1%)
Query: 5 VELSTKAKMPIVGLGTWRSL---LGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQE 61
V+L+ MP++G GT+ K E K+AI+A +RHID A+ Y N+ +VG AI+
Sbjct: 8 VKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRS 67
Query: 62 KIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGDD 121
KI + +V RED+F SK+W TF LVR A E +LK +L Y+D+YLIH P K G++
Sbjct: 68 KIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEE 127
Query: 122 FFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKPV 181
P D+ G +I WEAME+ D GL K++GVSNFN Q+E +LNKPGLKYKPV
Sbjct: 128 LSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPV 187
Query: 182 TNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSP-DRPWAKPEDPSLLEDPKIKEIAAK 240
NQVECHPY + KL+ +C SK I + AYS LGS D+ W P P LLEDP + +A K
Sbjct: 188 CNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKK 247
Query: 241 HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFD 300
HK+T A + +R+ +QR V V+ KS I +N+QVF+F+L+ E+M I +RN F+
Sbjct: 248 HKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFN 307
Query: 301 FKEFSHLEDFPFDAEY 316
F+ ++P+ EY
Sbjct: 308 SDSFASHPNYPYSDEY 323
>gi|207028673 hypothetical protein LOC100134257 [Homo sapiens]
Length = 139
Score = 100 bits (250), Expect = 1e-21
Identities = 52/116 (44%), Positives = 75/116 (64%), Gaps = 3/116 (2%)
Query: 5 VELSTKAKMPIVGLGTWRSL---LGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQE 61
V+L+ MP++G GT+ K EAVK+AI+A + HID A+ Y N+ +VG AI+
Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRS 67
Query: 62 KIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFK 117
KI + +V RED+F SK+W LVR A E++LK+L+L Y+D+YLIH+P K
Sbjct: 68 KIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
>gi|27436964 potassium voltage-gated channel, shaker-related
subfamily, beta member 1 isoform 3 [Homo sapiens]
Length = 401
Score = 36.6 bits (83), Expect = 0.030
Identities = 50/220 (22%), Positives = 92/220 (41%), Gaps = 39/220 (17%)
Query: 12 KMPIVGLGTWRSLLGKVKEAV-----KVAIDAEYRHIDCAYFY-ENQHEVGEAIQEKIQE 65
++ +GLGTW + G++ + V +A ++ D A Y + EV + I++
Sbjct: 82 RVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEV--ILGSIIKK 139
Query: 66 KAVMREDLFIVSKVW---PTFFERPLVRK----AFEKTLKDLKLSYLDVYLIHWPQGFKT 118
K R L I +K++ ER L RK + +L+ L+L Y+DV + P
Sbjct: 140 KGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRP----- 194
Query: 119 GDDFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLN--KPGL 176
D P + + AM ++++G+ G S ++ +I + +
Sbjct: 195 -DSNTPME-------------EIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFN 240
Query: 177 KYKPVTNQVECHPYLTQE---KLIQYCHSKGITVTAYSPL 213
PV Q E H + ++ +L + H G+ +SPL
Sbjct: 241 MIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPL 280
>gi|27436962 potassium voltage-gated channel, shaker-related
subfamily, beta member 1 isoform 2 [Homo sapiens]
Length = 408
Score = 36.6 bits (83), Expect = 0.030
Identities = 50/220 (22%), Positives = 92/220 (41%), Gaps = 39/220 (17%)
Query: 12 KMPIVGLGTWRSLLGKVKEAV-----KVAIDAEYRHIDCAYFY-ENQHEVGEAIQEKIQE 65
++ +GLGTW + G++ + V +A ++ D A Y + EV + I++
Sbjct: 89 RVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEV--ILGSIIKK 146
Query: 66 KAVMREDLFIVSKVW---PTFFERPLVRK----AFEKTLKDLKLSYLDVYLIHWPQGFKT 118
K R L I +K++ ER L RK + +L+ L+L Y+DV + P
Sbjct: 147 KGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRP----- 201
Query: 119 GDDFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLN--KPGL 176
D P + + AM ++++G+ G S ++ +I + +
Sbjct: 202 -DSNTPME-------------EIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFN 247
Query: 177 KYKPVTNQVECHPYLTQE---KLIQYCHSKGITVTAYSPL 213
PV Q E H + ++ +L + H G+ +SPL
Sbjct: 248 MIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPL 287
>gi|27436966 potassium voltage-gated channel, shaker-related
subfamily, beta member 1 isoform 1 [Homo sapiens]
Length = 419
Score = 36.6 bits (83), Expect = 0.030
Identities = 50/220 (22%), Positives = 92/220 (41%), Gaps = 39/220 (17%)
Query: 12 KMPIVGLGTWRSLLGKVKEAV-----KVAIDAEYRHIDCAYFY-ENQHEVGEAIQEKIQE 65
++ +GLGTW + G++ + V +A ++ D A Y + EV + I++
Sbjct: 100 RVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEV--ILGSIIKK 157
Query: 66 KAVMREDLFIVSKVW---PTFFERPLVRK----AFEKTLKDLKLSYLDVYLIHWPQGFKT 118
K R L I +K++ ER L RK + +L+ L+L Y+DV + P
Sbjct: 158 KGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRP----- 212
Query: 119 GDDFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLN--KPGL 176
D P + + AM ++++G+ G S ++ +I + +
Sbjct: 213 -DSNTPME-------------EIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFN 258
Query: 177 KYKPVTNQVECHPYLTQE---KLIQYCHSKGITVTAYSPL 213
PV Q E H + ++ +L + H G+ +SPL
Sbjct: 259 MIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPL 298
>gi|149944410 hypothetical protein LOC57587 [Homo sapiens]
Length = 532
Score = 31.6 bits (70), Expect = 0.96
Identities = 21/65 (32%), Positives = 26/65 (40%)
Query: 171 LNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLE 230
L P KYK E P T K Y TVT SPL +PD + + +
Sbjct: 216 LLSPKHKYKSGIKSTETQPSSTTPKCGHYPEESEDTVTDVSPLSTPDISPLQSFELGIAN 275
Query: 231 DPKIK 235
D K+K
Sbjct: 276 DQKVK 280
>gi|4504011 glutamate-cysteine ligase regulatory protein [Homo
sapiens]
Length = 274
Score = 30.4 bits (67), Expect = 2.1
Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 2/44 (4%)
Query: 142 WEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKPVTNQV 185
WE +E LV + A+G S+ + Q+E+L + KP +NQV
Sbjct: 147 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQ--WAQVKPNSNQV 188
>gi|55749998 deiodinase, iodothyronine, type II isoform b [Homo
sapiens]
Length = 309
Score = 28.5 bits (62), Expect = 8.2
Identities = 40/178 (22%), Positives = 66/178 (37%), Gaps = 17/178 (9%)
Query: 88 LVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGDDFFPKDDKGNMISGKGTFLDAWEAMEE 147
LV +A++ L L S+LD++++ + +G SG GT +E
Sbjct: 91 LVYEAYKSRL--LVYSHLDLWMVKLGEDAPNSSVVHVSSTEGGDNSGNGT--------QE 140
Query: 148 LVDEGLVKALGVSNFNHFQIERLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITV 207
+ EG L +F + ++N P T+Q+ KL++ S +
Sbjct: 141 KIAEGATCHL--LDFASPERPLVVNFGSATUPPFTSQLPAF-----RKLVEEFSSVADFL 193
Query: 208 TAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTTAQVLIRFHIQRNVTVIPKSM 265
Y P WA P D SL + K + Q+L RF + V+ M
Sbjct: 194 LVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRM 251
>gi|42822880 beta-lactamase-like [Homo sapiens]
Length = 279
Score = 28.5 bits (62), Expect = 8.2
Identities = 18/52 (34%), Positives = 28/52 (53%), Gaps = 7/52 (13%)
Query: 138 FLDAWEAMEELVDEGLVKALGVSNFNHFQIERL-------LNKPGLKYKPVT 182
++ E + ELVD GLV+ + +FN F ERL ++K G+ +K T
Sbjct: 208 YVGTCERLIELVDRGLVEKVLPGHFNTFGAERLFRLASNYISKAGICHKVST 259
>gi|122937514 unc-13 homolog C [Homo sapiens]
Length = 2214
Score = 28.5 bits (62), Expect = 8.2
Identities = 15/57 (26%), Positives = 30/57 (52%), Gaps = 8/57 (14%)
Query: 28 VKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQEKIQEKAVMREDLFIVSK---VWP 81
VK+ V+ +D+ Y+ Y ++N HE+ + + +++ + RED +K WP
Sbjct: 1542 VKDCVRACLDSTYK-----YIFDNCHELYSQLTDPSKKQDIPREDQGPTTKNLDFWP 1593
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,922,121
Number of Sequences: 37866
Number of extensions: 533660
Number of successful extensions: 1272
Number of sequences better than 10.0: 21
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1244
Number of HSP's gapped (non-prelim): 21
length of query: 316
length of database: 18,247,518
effective HSP length: 102
effective length of query: 214
effective length of database: 14,385,186
effective search space: 3078429804
effective search space used: 3078429804
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.