Guide to the Human Genome
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Search of human proteins with 122937496

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|122937496 WAS/WASL interacting protein family, member 3
[Homo sapiens]
         (483 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...  1028   0.0  
gi|18959210 WIRE protein [Homo sapiens]                               222   5e-58
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...   202   7e-52
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ...   202   7e-52
gi|47132519 Ras association and pleckstrin homology domains 1 is...   158   9e-39
gi|160707881 formin 2 [Homo sapiens]                                  142   9e-34
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   139   4e-33
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...   138   1e-32
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   131   2e-30
gi|163965366 nascent polypeptide-associated complex alpha subuni...   128   1e-29
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]    118   1e-26
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...   114   2e-25
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]                    112   6e-25
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]                    112   6e-25
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre...   112   6e-25
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ...   110   3e-24
gi|116284392 mucin 2 precursor [Homo sapiens]                         105   9e-23
gi|162329583 cleavage and polyadenylation specific factor 6, 68 ...   105   1e-22
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom...   103   3e-22
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom...   103   3e-22
gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sap...   103   3e-22
gi|150417989 cyclin K isoform 1 [Homo sapiens]                        103   3e-22
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]      101   2e-21
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]             100   3e-21
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    98   2e-20
gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens]               98   2e-20
gi|40807452 peroxisome proliferator-activated receptor gamma, co...    97   2e-20
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]          97   4e-20
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]          97   4e-20
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]          97   4e-20

>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score = 1028 bits (2658), Expect = 0.0
 Identities = 483/483 (100%), Positives = 483/483 (100%)

Query: 1   MPVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLR 60
           MPVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLR
Sbjct: 1   MPVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLR 60

Query: 61  KVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGG 120
           KVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGG
Sbjct: 61  KVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGG 120

Query: 121 KTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPP 180
           KTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPP
Sbjct: 121 KTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPP 180

Query: 181 PPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPA 240
           PPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPA
Sbjct: 181 PPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPA 240

Query: 241 SVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYA 300
           SVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYA
Sbjct: 241 SVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYA 300

Query: 301 SCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQK 360
           SCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQK
Sbjct: 301 SCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQK 360

Query: 361 KRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQPGGQLRNGSLHIIDDFE 420
           KRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQPGGQLRNGSLHIIDDFE
Sbjct: 361 KRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQPGGQLRNGSLHIIDDFE 420

Query: 421 SKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRTPGPWLQAEAVGQSSDDIKGRNSQVTQA 480
           SKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRTPGPWLQAEAVGQSSDDIKGRNSQVTQA
Sbjct: 421 SKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRTPGPWLQAEAVGQSSDDIKGRNSQVTQA 480

Query: 481 SCL 483
           SCL
Sbjct: 481 SCL 483


>gi|18959210 WIRE protein [Homo sapiens]
          Length = 440

 Score =  222 bits (566), Expect = 5e-58
 Identities = 176/506 (34%), Positives = 224/506 (44%), Gaps = 123/506 (24%)

Query: 1   MPVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLR 60
           MP+PPPPPPP           PPPPP+    +T+   L R + +GR ALL DI +GT+L+
Sbjct: 1   MPIPPPPPPP---------PGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLK 51

Query: 61  KVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRD---- 116
           KVT INDRSAP +E  KG++    G   + GA+  P  G LF GG   LRP G +D    
Sbjct: 52  KVTNINDRSAPILEKPKGSS----GGYGSGGAALQPK-GGLFQGGVLKLRPVGAKDGSEN 106

Query: 117 VAGGKTGQGPGSRAPSPRLPNKTISG-------------PLIP----PASPRLG--NTSE 157
           +AG    Q P SRA +PR P    SG             P +P    P+ P L   NT+ 
Sbjct: 107 LAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTS 166

Query: 158 AHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAP 217
           + G   ++    + P PPPP      PP P P+ SS   K P  +   PL         P
Sbjct: 167 STGMKHSS----SAPPPPPPGRRANAPPTPLPMHSS---KAPAYNREKPL---------P 210

Query: 218 PVPCAPPPP----PPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYP 273
           P P     P    PP PPP  PP  P ++        +  P      PPP P   P   P
Sbjct: 211 PTPGQRLHPGREGPPAPPPVKPPPSPVNI--------RTGPSGQSLAPPPPPYRQP---P 259

Query: 274 GLKAEPASPAQDA------------QEPPAP----PPPLPPYASCSPRASLPAPPLPGVN 317
           G+   P+SP  ++            ++ P P     PP P  AS S  ++ P PP     
Sbjct: 260 GVPNGPSSPTNESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPP 319

Query: 318 SSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPP 377
           S    PPP PP          + GA+  P PP P         + HG      GK   PP
Sbjct: 320 SRGAAPPPPPPVI--------RNGARDAPPPPPP--------YRMHGSEPPSRGK---PP 360

Query: 378 APPARSPTTELSSKSQQATAWTPTQQPGGQLRNGS-------LHIIDDFESKFTFHSVED 430
            PP+R+P               P   P   LRNG           +DDFESK++FH VED
Sbjct: 361 PPPSRTPA-------------GPPPPPPPPLRNGHRDSITTVRSFLDDFESKYSFHPVED 407

Query: 431 FPPPDEYKPCQKIYPSKIPRSRTPGP 456
           FP P+EYK  Q+IYPSK  R+    P
Sbjct: 408 FPAPEEYKHFQRIYPSKTNRAARGAP 433


>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score =  202 bits (513), Expect = 7e-52
 Identities = 167/515 (32%), Positives = 223/515 (43%), Gaps = 103/515 (20%)

Query: 11  LPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSA 70
           +P PPPP    PPPPP+    +T+  +L + +  GR+ALL+DI +G +L+K T  NDRSA
Sbjct: 1   MPVPPPPA---PPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKK-TVTNDRSA 56

Query: 71  PQIESSKGTNKEGGGSA----------------NTRGASTPPTLGDLFAGGFPVLRPAGQ 114
           P ++  KG    GGG                   + G   PP LG LF  G P LR    
Sbjct: 57  PILDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTAN 116

Query: 115 RDVAGGKTGQGPGSRAPS-PRLPNKTISGPLIPPASP-RLGNTSEAHGAARTAPPRPNVP 172
           RD   G      GSR P  P     T + P  PP+ P R    S  H   R+ PP P   
Sbjct: 117 RDNDSG------GSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGH---RSGPPEPQRN 167

Query: 173 APPPPTPP--PPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAP--PPPPP 228
             PPP P     P  +PPP+PS     TP      P  +G+     PPVP  P  P P P
Sbjct: 168 RMPPPRPDVGSKPDSIPPPVPS-----TPRPIQSSPHNRGS-----PPVPGGPRQPSPGP 217

Query: 229 PPPPTP--------------PPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGY-P 273
            PPP P               PL  +S  S++   P      L   PPP P  PP G  P
Sbjct: 218 TPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPP--PPVGNRP 275

Query: 274 GLKAE--PASPAQDAQEPPAPPPPLPPYASCSPRASLPA-----PPLPGVNSSSETPPPL 326
            +  E  P  P Q+  +PP P  P P  +S +P    P      PPLP  +S ++  P L
Sbjct: 276 SIHREAVPPPPPQN-NKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRL 334

Query: 327 PPKSPSFQA--PPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP 384
           P ++ S  +  PP  +  ++ P PP P    P   +   GR G       PPP P +R+ 
Sbjct: 335 PQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGP-----LPPPPPVSRNG 389

Query: 385 TT--------ELSSKS----------------QQATAWTPTQQPGGQLRNG--SLHIIDD 418
           +T        +L S+S                + +    P   P   +RNG       D+
Sbjct: 390 STSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDE 449

Query: 419 FESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRT 453
           +ES+F FH + D PPP+ Y    K YPSK+ R+ +
Sbjct: 450 WESRFYFHPISDLPPPEPYVQTTKSYPSKLARNES 484



 Score =  102 bits (255), Expect = 6e-22
 Identities = 122/423 (28%), Positives = 153/423 (36%), Gaps = 106/423 (25%)

Query: 2   PVPPPPPP---PLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTR 58
           P  PP  P   P+P P    G P P     PP   D  S   + P    +    IQ    
Sbjct: 140 PFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSP- 198

Query: 59  LRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVA 118
                  ++R +P +         GG    + G + PP         FP     G R  A
Sbjct: 199 -------HNRGSPPVP--------GGPRQPSPGPTPPP---------FP-----GNRGTA 229

Query: 119 --GGKTGQGP-------GSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPP-- 167
             GG   Q P        +R P P  P++ +     PP  P +GN    H  A   PP  
Sbjct: 230 LGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKP-PPPPPPVGNRPSIHREAVPPPPPQ 288

Query: 168 --RPNVP----------APPPPTPP--PPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLP 213
             +P VP          APPPP PP  P PPPLPP   SS   +TP +    P    +L 
Sbjct: 289 NNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPP--SSSGNDETPRL----PQRNLSLS 342

Query: 214 VVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYP 273
              PP+P      P PPPP+  P PP           +  P    P+PPP    PP    
Sbjct: 343 SSTPPLPSPGRSGPLPPPPSERPPPPV----------RDPPGRSGPLPPP----PPVSRN 388

Query: 274 GLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSP-- 331
           G     A PA          P LP  +      S P PPLP    S+  PPP PP +   
Sbjct: 389 G-STSRALPA---------TPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIR 438

Query: 332 -SFQAPPQKAGAQA---------LPAPPAP----PGSQPFLQKKRHGRPGAGGGKLNPPP 377
             FQ  P +   ++         LP PP P      S P    +   R G+   +   PP
Sbjct: 439 NGFQDSPCEDEWESRFYFHPISDLP-PPEPYVQTTKSYPSKLARNESRSGSNRRERGAPP 497

Query: 378 APP 380
            PP
Sbjct: 498 LPP 500


>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score =  202 bits (513), Expect = 7e-52
 Identities = 167/515 (32%), Positives = 223/515 (43%), Gaps = 103/515 (20%)

Query: 11  LPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSA 70
           +P PPPP    PPPPP+    +T+  +L + +  GR+ALL+DI +G +L+K T  NDRSA
Sbjct: 1   MPVPPPPA---PPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKK-TVTNDRSA 56

Query: 71  PQIESSKGTNKEGGGSA----------------NTRGASTPPTLGDLFAGGFPVLRPAGQ 114
           P ++  KG    GGG                   + G   PP LG LF  G P LR    
Sbjct: 57  PILDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTAN 116

Query: 115 RDVAGGKTGQGPGSRAPS-PRLPNKTISGPLIPPASP-RLGNTSEAHGAARTAPPRPNVP 172
           RD   G      GSR P  P     T + P  PP+ P R    S  H   R+ PP P   
Sbjct: 117 RDNDSG------GSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGH---RSGPPEPQRN 167

Query: 173 APPPPTPP--PPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAP--PPPPP 228
             PPP P     P  +PPP+PS     TP      P  +G+     PPVP  P  P P P
Sbjct: 168 RMPPPRPDVGSKPDSIPPPVPS-----TPRPIQSSPHNRGS-----PPVPGGPRQPSPGP 217

Query: 229 PPPPTP--------------PPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGY-P 273
            PPP P               PL  +S  S++   P      L   PPP P  PP G  P
Sbjct: 218 TPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPP--PPVGNRP 275

Query: 274 GLKAE--PASPAQDAQEPPAPPPPLPPYASCSPRASLPA-----PPLPGVNSSSETPPPL 326
            +  E  P  P Q+  +PP P  P P  +S +P    P      PPLP  +S ++  P L
Sbjct: 276 SIHREAVPPPPPQN-NKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRL 334

Query: 327 PPKSPSFQA--PPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP 384
           P ++ S  +  PP  +  ++ P PP P    P   +   GR G       PPP P +R+ 
Sbjct: 335 PQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGP-----LPPPPPVSRNG 389

Query: 385 TT--------ELSSKS----------------QQATAWTPTQQPGGQLRNG--SLHIIDD 418
           +T        +L S+S                + +    P   P   +RNG       D+
Sbjct: 390 STSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDE 449

Query: 419 FESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRT 453
           +ES+F FH + D PPP+ Y    K YPSK+ R+ +
Sbjct: 450 WESRFYFHPISDLPPPEPYVQTTKSYPSKLARNES 484



 Score =  102 bits (255), Expect = 6e-22
 Identities = 122/423 (28%), Positives = 153/423 (36%), Gaps = 106/423 (25%)

Query: 2   PVPPPPPP---PLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTR 58
           P  PP  P   P+P P    G P P     PP   D  S   + P    +    IQ    
Sbjct: 140 PFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSP- 198

Query: 59  LRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVA 118
                  ++R +P +         GG    + G + PP         FP     G R  A
Sbjct: 199 -------HNRGSPPVP--------GGPRQPSPGPTPPP---------FP-----GNRGTA 229

Query: 119 --GGKTGQGP-------GSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPP-- 167
             GG   Q P        +R P P  P++ +     PP  P +GN    H  A   PP  
Sbjct: 230 LGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKP-PPPPPPVGNRPSIHREAVPPPPPQ 288

Query: 168 --RPNVP----------APPPPTPP--PPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLP 213
             +P VP          APPPP PP  P PPPLPP   SS   +TP +    P    +L 
Sbjct: 289 NNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPP--SSSGNDETPRL----PQRNLSLS 342

Query: 214 VVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYP 273
              PP+P      P PPPP+  P PP           +  P    P+PPP    PP    
Sbjct: 343 SSTPPLPSPGRSGPLPPPPSERPPPPV----------RDPPGRSGPLPPP----PPVSRN 388

Query: 274 GLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSP-- 331
           G     A PA          P LP  +      S P PPLP    S+  PPP PP +   
Sbjct: 389 G-STSRALPA---------TPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIR 438

Query: 332 -SFQAPPQKAGAQA---------LPAPPAP----PGSQPFLQKKRHGRPGAGGGKLNPPP 377
             FQ  P +   ++         LP PP P      S P    +   R G+   +   PP
Sbjct: 439 NGFQDSPCEDEWESRFYFHPISDLP-PPEPYVQTTKSYPSKLARNESRSGSNRRERGAPP 497

Query: 378 APP 380
            PP
Sbjct: 498 LPP 500


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score =  158 bits (400), Expect = 9e-39
 Identities = 148/498 (29%), Positives = 193/498 (38%), Gaps = 137/498 (27%)

Query: 2    PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRK 61
            P PP PPPP PPPPPP   PPPPPP  P  S    S   A P     +       TRL+ 
Sbjct: 624  PSPPLPPPPPPPPPPP---PPPPPPPPPLPSQSAPSAGSAAP-----MFVKYSTITRLQN 675

Query: 62   VTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGK 121
             +Q                       ++     PPT         PV++           
Sbjct: 676  ASQ-----------------------HSGALFKPPTP--------PVMQ----------- 693

Query: 122  TGQGPGSRAPSPRL---PNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPP-- 176
                  S++  P++   PN  +  P  PP  P  G+       A  AP  P   APPP  
Sbjct: 694  ------SQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPL 747

Query: 177  ------------PTPPPPPPPLPPPLPSSSPIKTPLVSPPGPL-TKGNLPVV---APPVP 220
                        P  PPPPPP+P PLP  +P K PLV+ P P  TK   PVV   APP P
Sbjct: 748  KIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPK-PLVTIPAPTSTKTVAPVVTQAAPPTP 806

Query: 221  CAPPPPP-----------PPPPPTPP-PLPPASVLSDKAVKPQLAPLHLPPIPPPLPLL- 267
              P PP            PP PPTPP P+PP ++   ++   +  P  L P+P  +  + 
Sbjct: 807  TPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIA 866

Query: 268  ----PPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETP 323
                PP   P ++++P  P      P    P  PP     P+    + P+P    S + P
Sbjct: 867  SQFPPPPTPPAMESQPLKPV-----PANVAPQSPPAVKAKPKWQPSSIPVP----SPDFP 917

Query: 324  PPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQK-----KRHGRPGAGGGKLNPPPA 378
            PP PP+S S   PP        P PP PP + P   K     K+  +  + GGK  PPP 
Sbjct: 918  PP-PPES-SLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGK-KPPPT 974

Query: 379  PPARSPTTELSSKSQQATAWTPTQQPGGQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYK 438
            P   S     S KS         ++P           +D   SKFT       PP +   
Sbjct: 975  PQRNS-----SIKSSSGAEHPEPKRPS----------VDSLVSKFT-------PPAESGS 1012

Query: 439  PCQKIYPSKIPRSRTPGP 456
            P ++  P   P +  P P
Sbjct: 1013 PSKETLP---PPAAPPKP 1027



 Score =  100 bits (250), Expect = 2e-21
 Identities = 131/484 (27%), Positives = 161/484 (33%), Gaps = 123/484 (25%)

Query: 1    MPVPPPPPPP---------LPPPP-----PPLGAPPPP-------------PPSAPPVST 33
            +P PPPPPPP         L P P     P   APPPP             PP+ PP   
Sbjct: 709  VPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPP 768

Query: 34   DTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGAS 93
              + L    P+     L  I   T  + V  +  ++AP                      
Sbjct: 769  IPAPL---PPQAPPKPLVTIPAPTSTKTVAPVVTQAAPP-------------------TP 806

Query: 94   TPPTLGDLFAGGFPV--LRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPR 151
            TPP         FP   + P+             P    P P LP K  S    PP SP 
Sbjct: 807  TPPVPPAKKQPAFPASYIPPSPPT----------PPVPVPPPTLP-KQQSFCAKPPPSPL 855

Query: 152  LGNTSEAHGAARTAPPRPNVPA----PPPPTPPPPPPPLPPPL-------PSSSPIKTPL 200
                S     A   PP P  PA    P  P P    P  PP +       PSS P+ +P 
Sbjct: 856  SPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPD 915

Query: 201  VSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPI 260
              PP P +    P   PP P   P PPPPPPPT  P P  S    K      +P    P 
Sbjct: 916  FPPPPPESSLVFP---PPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPP 972

Query: 261  PPP-----LPLLPPCGYPGLK--------------AEPASPAQDAQEPPAPPPPLP---- 297
            P P     +       +P  K              AE  SP+++   PPA PP       
Sbjct: 973  PTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNL 1032

Query: 298  -----PYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPP--- 349
                 P        S  AP L G    S    P PP    F  PP +     LP PP   
Sbjct: 1033 SGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPET---ELPLPPIEI 1089

Query: 350  --------APPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSK--SQQATAWT 399
                    +P  +    Q ++  +      K  PPP  P R+ +T L+    S+Q T  T
Sbjct: 1090 PAVFSGNTSPKVAVVNPQPQQWSKMSV---KKAPPPTRPKRNDSTRLTQAEISEQPTMAT 1146

Query: 400  PTQQ 403
               Q
Sbjct: 1147 VVPQ 1150



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 99/380 (26%), Positives = 134/380 (35%), Gaps = 87/380 (22%)

Query: 121 KTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPP 180
           ++  G     P+  + +++I   +   A  R     E+  A   +  RP     PP +P 
Sbjct: 553 QSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKARMESMNRPYTSLVPPLSPQ 612

Query: 181 PPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPA 240
           P    +  P  +S P      SPP            PP P  PPPPPPPPPP PPPLP  
Sbjct: 613 PK---IVTPYTASQP------SPP-----------LPPPPPPPPPPPPPPPPPPPPLPSQ 652

Query: 241 S-------------------------------------VLSDKAVKPQL--APLHLPPIP 261
           S                                     V+  ++VKPQ+   P  + P P
Sbjct: 653 SAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPP 712

Query: 262 PPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPY-----ASCSPRASLPAPPLPGV 316
           PP P  P  G    + +PA  A    +  APPPPL  +        +P    P PP+P  
Sbjct: 713 PPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAP 772

Query: 317 NSSSETPPPL----PPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGK 372
                 P PL     P S    AP     A   P PP PP  +         +P      
Sbjct: 773 LPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKK---------QPAFPASY 823

Query: 373 LNP-PPAPPARSPTTELSSKSQQATAWTPTQQPGGQLRNGSLHIIDDFESKFTFHSVEDF 431
           + P PP PP   P   L    QQ+    P   P   + +    I   F    T       
Sbjct: 824 IPPSPPTPPVPVPPPTL--PKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPT------- 874

Query: 432 PPPDEYKPCQKIYPSKIPRS 451
           PP  E +P + +  +  P+S
Sbjct: 875 PPAMESQPLKPVPANVAPQS 894



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 147/572 (25%), Positives = 174/572 (30%), Gaps = 218/572 (38%)

Query: 3    VPPPPPPPLPPPP----------------PPLGAPPPP-------------PPSAPPVST 33
            VPPPPPPP PP P                P   APPPP             PP+ PP   
Sbjct: 709  VPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPP 768

Query: 34   DTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGAS 93
              + L    P+     L  I   T  + V  +  ++AP                      
Sbjct: 769  IPAPL---PPQAPPKPLVTIPAPTSTKTVAPVVTQAAPP-------------------TP 806

Query: 94   TPPTLGDLFAGGFPV--LRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPR 151
            TPP         FP   + P+             P    P P LP K  S    PP SP 
Sbjct: 807  TPPVPPAKKQPAFPASYIPPSPPT----------PPVPVPPPTLP-KQQSFCAKPPPSPL 855

Query: 152  LGNTSEAHGAARTAPPRPNVPA----PPPPTPPPPPPPLPPPL-------PSSSPIKTPL 200
                S     A   PP P  PA    P  P P    P  PP +       PSS P+ +P 
Sbjct: 856  SPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPD 915

Query: 201  VSPPGPLTKGNLPVVAP-PVPCAPPPPPPP-------------------------PPPTP 234
              PP P +    P   P PVP  PPPPPP                          PPPTP
Sbjct: 916  FPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTP 975

Query: 235  ----------------PPLPPASVLSDKAVKPQ---------LAPLHLPPIPPPLPL--- 266
                            P  P    L  K   P          L P   PP P  L L   
Sbjct: 976  QRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGV 1035

Query: 267  -LPPCGYPGLKAEPA---------------SPAQDAQEPPAPPP---PLPPY-------A 300
             LP     G  +  A               SP  D+  PP PP    PLPP         
Sbjct: 1036 NLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSG 1095

Query: 301  SCSPRASL--PAPPLPGVNSSSETPPPLPPKS------PSFQAPPQKAGAQALPAPPAPP 352
            + SP+ ++  P P      S  + PPP  PK          +   Q   A  +P  P  P
Sbjct: 1096 NTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSP 1155

Query: 353  GS----QP--------FLQKK---RHG--------------------------------R 365
             S    QP         LQ+K   RHG                                +
Sbjct: 1156 KSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPPELLSDQQK 1215

Query: 366  PGAGGGKLN--------PPPAPPARSPTTELS 389
             G GG  ++        PPPAPP R   T+LS
Sbjct: 1216 AGYGGSHISGYATLRRGPPPAPPKRDQNTKLS 1247



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 91/362 (25%), Positives = 126/362 (34%), Gaps = 64/362 (17%)

Query: 1    MPVPPPPPPPLPP------PPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQ 54
            +PVP P  PP PP      PPPP    P PPP  PP ++ T      D  G         
Sbjct: 909  IPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPT-----PDKSG--------S 955

Query: 55   QGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQ 114
             G +  K +    +  P       + K   G+ +       P++  L +   P   PA  
Sbjct: 956  PGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPE--PKRPSVDSLVSKFTP---PA-- 1008

Query: 115  RDVAGGKTGQGPGSRAPSPRLPNK----TISGPLIPPASPRLGNTSEAHG-AARTAPPRP 169
                  ++G       P P  P K     +SG  +P    +   +++A   + R      
Sbjct: 1009 ------ESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVV 1062

Query: 170  NVPAPPPPTP-PPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAP-PVPCAPPPPP 227
              P+PP  +  PPPPP    PLP   PI+ P V      T   + VV P P   +     
Sbjct: 1063 EFPSPPSDSDFPPPPPETELPLP---PIEIPAVFSGN--TSPKVAVVNPQPQQWSKMSVK 1117

Query: 228  PPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAE--------- 278
              PPPT P    ++ L+   +  Q     + P  P  P       PG  A+         
Sbjct: 1118 KAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKS 1177

Query: 279  -----PASPAQDAQEPPAP------PPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLP 327
                   S      EP A       PPP P   S   +A      + G  +    PPP P
Sbjct: 1178 ITRHGSLSSRMSRAEPTATMDDMALPPPPPELLSDQQKAGYGGSHISGYATLRRGPPPAP 1237

Query: 328  PK 329
            PK
Sbjct: 1238 PK 1239


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score =  142 bits (357), Expect = 9e-34
 Identities = 134/413 (32%), Positives = 151/413 (36%), Gaps = 96/413 (23%)

Query: 3    VPPPPP----PPLPPPPPPL-GAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGT 57
            +P PPP      LPPPPPPL GA  PPPP  P               G   L      G 
Sbjct: 896  IPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLP---------------GAGILPLPPLPGA 940

Query: 58   RLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDV 117
             +     +   + P      G            G   PP L      G P   P      
Sbjct: 941  GIPPPPPLPGAAIPPPPPLPGA-----------GIPLPPPLP---GAGIPPPPPL----- 981

Query: 118  AGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPP 177
                    PG+  P P      + G  IPP  P  G            PP P    PPPP
Sbjct: 982  --------PGAGIPPP----PPLPGAGIPPPPPLPG------AGIPPPPPLPGAGIPPPP 1023

Query: 178  TPP----PPPPPLPPP-LPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP- 231
              P    PPPPPLP   +P   P+    + PP PL    +P   PP+P A  PPPPP P 
Sbjct: 1024 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP-PPPLPGAGIPPPPPLPG 1082

Query: 232  ---PTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLP---LLPPCGYPGLKAEPASPAQD 285
               P PPPLP A +       P L  + +PP PPPLP   + PP   PG    P  P   
Sbjct: 1083 AGIPPPPPLPGAGI----PPPPPLPGVGIPP-PPPLPGAGIPPPPPLPGAGIPPPPPLPG 1137

Query: 286  AQEPPAPP------PPLPPYASCS-------PRASL-PAPPLPGVNSSSETPPPLPPKSP 331
            A  PP PP      PP PP            P A + P PPLPGV      PPP P    
Sbjct: 1138 AGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVG----IPPPPPLPGV 1193

Query: 332  SFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP 384
                PP   GA   P PP P    P         PG G   + PPP  P   P
Sbjct: 1194 GIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTG---IPPPPLLPVSGP 1243



 Score =  137 bits (346), Expect = 2e-32
 Identities = 128/382 (33%), Positives = 147/382 (38%), Gaps = 72/382 (18%)

Query: 1    MPVPP------PPPPPLP----PPPPPL---GAP-PPPPPSA---PPVSTDTSSLRRADP 43
            +P+PP      PPPPPLP    PPPPPL   G P PPP P A   PP     + +    P
Sbjct: 932  LPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPP 991

Query: 44   KGRSALLADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFA 103
                        G  +     +     P      G            G   PP L     
Sbjct: 992  ----------LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP---G 1038

Query: 104  GGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAAR 163
             G P   P     +       G G   P P      + G  IPP  P  G          
Sbjct: 1039 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPP------LPGAGIPPPPPLPG------AGIP 1086

Query: 164  TAPPRPNVPAPPPPTPP----PPPPPLP-PPLPSSSPIKTPLVSPPGPLTKGNLPVVAPP 218
              PP P    PPPP  P    PPPPPLP   +P   P+    + PP PL    +P   PP
Sbjct: 1087 PPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP-PPPP 1145

Query: 219  VPCAPPPPPPPPP----PTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLP---LLPPCG 271
            +P    PPPPP P    P PPPLP A +       P L  + +PP PPPLP   + PP  
Sbjct: 1146 LPRVGIPPPPPLPGAGIPPPPPLPGAGI----PPPPPLPGVGIPP-PPPLPGVGIPPPPP 1200

Query: 272  YPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSP 331
             PG    P  P      PPAP PPLPP     P   +P PPL  V+     PP LP    
Sbjct: 1201 LPGAGIPPPPPLPGMGIPPAPAPPLPP-----PGTGIPPPPLLPVSG----PPLLPQVGS 1251

Query: 332  SFQAPPQKAGAQALPAPPAPPG 353
            S    PQ  G   LP PP P G
Sbjct: 1252 STLPTPQVCG--FLP-PPLPSG 1270



 Score =  126 bits (317), Expect = 4e-29
 Identities = 111/310 (35%), Positives = 124/310 (40%), Gaps = 70/310 (22%)

Query: 131  PSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPA----PPPPTP------- 179
            P P LP  T+  P +P  S  +       G     PP P +P     PPPP P       
Sbjct: 879  PPPPLPGMTV--PTLP--STAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPL 934

Query: 180  --------PPPPP------PLPPPLPSSS-PIKTPL----VSPPGPLTKGNLPVVAPPVP 220
                    PPPPP      P PPPLP +  P+  PL    + PP PL    +P   PP+P
Sbjct: 935  PPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPP-PPPLP 993

Query: 221  CAP-PPPPP------PPP--------PTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLP 265
             A  PPPPP      PPP        P PPPLP A +       P L    +PP PPPLP
Sbjct: 994  GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI----PPPPPLPGAGIPP-PPPLP 1048

Query: 266  ---LLPPCGYPGLKAEPASPAQDAQEPPAPPPP---LPPYASCSPRASLPAPPLPGVNSS 319
               + PP   PG    P  P   A  PP PP P   +PP          P PPLPGV   
Sbjct: 1049 GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVG-- 1106

Query: 320  SETPPPLPPKSPSFQAPPQKAGAQALPAPPAP-PGSQPFLQKKRHGRPG----AGGGKLN 374
               PPP P        PP   GA   P PP P  G  P     R G P      G G   
Sbjct: 1107 --IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPP 1164

Query: 375  PPPAPPARSP 384
            PPP P A  P
Sbjct: 1165 PPPLPGAGIP 1174



 Score =  124 bits (311), Expect = 2e-28
 Identities = 99/289 (34%), Positives = 112/289 (38%), Gaps = 66/289 (22%)

Query: 146  PPASPRLGNTSEAHGAARTAPPRPNVPA-----------------------PPPPTP--- 179
            PP  P   ++S   G     PP P +P                        PPPP P   
Sbjct: 858  PPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPG 917

Query: 180  --PPPPPPLP-------PPLPSSS-----PIKTPLVSPPGPLTKGNLPVVAPPVPCAPPP 225
               PPPPPLP       PPLP +      P+    + PP PL    +P + PP+P A  P
Sbjct: 918  AGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIP-LPPPLPGAGIP 976

Query: 226  PPPPPP----PTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLP---LLPPCGYPGLKAE 278
            PPPP P    P PPPLP A +       P L    +PP PPPLP   + PP   PG    
Sbjct: 977  PPPPLPGAGIPPPPPLPGAGI----PPPPPLPGAGIPP-PPPLPGAGIPPPPPLPGAGIP 1031

Query: 279  PASPAQDAQEPPAPPPP---LPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQA 335
            P  P   A  PP PP P   +PP          P PPLPG       PPP P        
Sbjct: 1032 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG----IPPPPPLPGAGIPP 1087

Query: 336  PPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP 384
            PP   GA   P PP P    P         P  G G   PPP P A  P
Sbjct: 1088 PPPLPGAGIPPPPPLPGVGIP------PPPPLPGAGIPPPPPLPGAGIP 1130



 Score =  119 bits (299), Expect = 5e-27
 Identities = 95/274 (34%), Positives = 109/274 (39%), Gaps = 59/274 (21%)

Query: 155  TSEAHGAARTAPPRPNVPAPPP-------------PTPPPPPPPLP----PPLPSSSPIK 197
            TS  H  +       N+P+PPP                PPPPPPLP    P LPS++  +
Sbjct: 839  TSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQ 898

Query: 198  TP-------LVSPPGPLTKGNLP----------VVAPPVPCAPPPPPPPPP----PTPPP 236
             P       L  PP PL    +P          +  PP+P A  PPPPP P    P PPP
Sbjct: 899  PPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPP 958

Query: 237  LPPASVLSDKAVKPQLAPLHLPPIPPPLP---LLPPCGYPGLKAEPASPAQDAQEPPAPP 293
            LP A +     + P L    +PP PPPLP   + PP   PG    P  P   A  PP PP
Sbjct: 959  LPGAGI----PLPPPLPGAGIPP-PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1013

Query: 294  PP---LPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPA 350
             P   +PP          P PPLPG       PPP P        PP   GA   P PP 
Sbjct: 1014 LPGAGIPPPPPLPGAGIPPPPPLPGAG----IPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1069

Query: 351  PPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP 384
            P    P         P  G G   PPP P A  P
Sbjct: 1070 PGAGIP------PPPPLPGAGIPPPPPLPGAGIP 1097



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 83/243 (34%), Positives = 93/243 (38%), Gaps = 58/243 (23%)

Query: 179  PPPPP----------PPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPP-VPCA----- 222
            PPPPP          P   PP   S+  +T          K +  + +PP +PC      
Sbjct: 810  PPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSS 869

Query: 223  -------PPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLH----LPPIPPPLP---LLP 268
                   PPPPPP P  T P LP  ++       PQ  PL     LPP PPPLP   + P
Sbjct: 870  MPGLGMVPPPPPPLPGMTVPTLPSTAI-------PQPPPLQGTEMLPPPPPPLPGAGIPP 922

Query: 269  PCGYPGLKAEPASPAQDAQEPPAPP------PPLPPYASCSPRASLP-APPLPGVNSSSE 321
            P   PG    P  P   A  PP PP      PP PP     P A +P  PPLPG      
Sbjct: 923  PPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPL----PGAGIPLPPPLPGAG---- 974

Query: 322  TPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPA 381
             PPP P        PP   GA   P PP P    P         P  G G   PPP P A
Sbjct: 975  IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAGIPPPPPLPGA 1028

Query: 382  RSP 384
              P
Sbjct: 1029 GIP 1031



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 101/317 (31%), Positives = 117/317 (36%), Gaps = 47/317 (14%)

Query: 2    PVPP------PPPPPLP----PPPPPL---GAPPPPP-PSA---PPVSTDTSSLRRADP- 43
            P PP      PPPPPLP    PPPPPL   G PPPPP P A   PP     + +    P 
Sbjct: 988  PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1047

Query: 44   KGRSALLADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFA 103
             G          G  +     +     P      G            G   PP L  +  
Sbjct: 1048 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGV-- 1105

Query: 104  GGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPL------IPPASPRLGNTSE 157
             G P   P     +       G G   P P LP   I  P       IPP  P  G    
Sbjct: 1106 -GIPPPPPLPGAGIPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPRVGIPPPPPLPG---- 1159

Query: 158  AHGAARTAPPRPNVPAPPPPTPP----PPPPPLP-PPLPSSSPIKTPLVSPPGPLT-KGN 211
                    PP P    PPPP  P    PPPPPLP   +P   P+    + PP PL   G 
Sbjct: 1160 --AGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGI 1217

Query: 212  LPVVAPPVPCAPP----PPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLL 267
             P  APP+P  PP    PPPP  P + PPL P  V S     PQ+     PP+P  L  L
Sbjct: 1218 PPAPAPPLP--PPGTGIPPPPLLPVSGPPLLP-QVGSSTLPTPQVCGFLPPPLPSGLFGL 1274

Query: 268  PPCGYPGLKAEPASPAQ 284
                  G + +P  P +
Sbjct: 1275 GMNQDKGSRKQPIEPCR 1291



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 71/325 (21%), Positives = 99/325 (30%), Gaps = 51/325 (15%)

Query: 153 GNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNL 212
           G   EA G+  T      +   P      P  P  PP P   P+                
Sbjct: 258 GGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSE-------------- 303

Query: 213 PVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKP------------QLAPLHLPPI 260
              AP +P A P     P  T  P P A    + A  P            + A    P  
Sbjct: 304 ---APSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRG 360

Query: 261 PPPLPLLPPCGYPGLKAEPASPAQDAQEPPAP-PPPLPPYASCSPRASLPAPPLPGVNSS 319
            P     P  G    +     P ++AQ P AP    LP   + S R   P P +      
Sbjct: 361 SPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIK 420

Query: 320 SETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQK-----KRHGRPG--AGGGK 372
           + T     P     Q+P Q    +  P P    GS+  L       K+H   G  A G  
Sbjct: 421 TTTRQLSSPNHSPSQSPNQSPRIKRRPEPSLSRGSRTALASVAAPAKKHRADGGLAAGLS 480

Query: 373 LNPPPAPPARSPTTELSSKSQQATAWTPTQQPGG------QLRNGSLHIIDDFESKFT-- 424
            +        + T  +   +        +   GG         +G+    D F++ FT  
Sbjct: 481 RSADWTEELGARTPRVGGSAHLLERGVASDSGGGVSPALAAKASGAPAAADGFQNVFTGR 540

Query: 425 ------FHSVEDFPPPDEYKPCQKI 443
                 F   E+ PP +  K C +I
Sbjct: 541 TLLEKLFSQQENGPPEEAEKFCSRI 565



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 35/122 (28%), Positives = 44/122 (36%), Gaps = 14/122 (11%)

Query: 243 LSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPP--------- 293
           L  +  + QL     P  PP      P  + GL      P+  A E P  P         
Sbjct: 217 LQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSAL 276

Query: 294 PPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPG 353
             LP   +  PR     PP PG    SE  P LP   P+ +  P    + A P P A PG
Sbjct: 277 SDLPESLAAEPREP-QQPPSPGGLPVSEA-PSLPAAQPAAKDSP---SSTAFPFPEAGPG 331

Query: 354 SQ 355
            +
Sbjct: 332 EE 333



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 42/160 (26%), Positives = 63/160 (39%), Gaps = 22/160 (13%)

Query: 284 QDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQ 343
           Q A+EP APP  + P     P A L      G++        L P   + +AP      Q
Sbjct: 227 QGAEEPAAPPTAVSP----QPGAFL------GLDRFL-----LGPSGGAGEAPGSPDTEQ 271

Query: 344 ALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWT-PTQ 402
           AL A    P S     ++    P  GG  ++  P+ PA  P    +  S  +TA+  P  
Sbjct: 272 ALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPSLPAAQPA---AKDSPSSTAFPFPEA 328

Query: 403 QPGGQLRNGSLHIIDDFESKFTFHSVEDFP---PPDEYKP 439
            PG +     +    D + +    + ED P   P +E+ P
Sbjct: 329 GPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAP 368



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 42/145 (28%), Positives = 51/145 (35%), Gaps = 17/145 (11%)

Query: 227 PPPPPPTPPPLPPASVLSDK-AVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQD 285
           P  PP    P P A +  D+  + P       P  P     L       L   P S A +
Sbjct: 232 PAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALS-----ALSDLPESLAAE 286

Query: 286 AQEPPAPPPP--LPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQ 343
            +EP  PP P  LP     S   SLPA      +S S T  P P   P  +A    AGA 
Sbjct: 287 PREPQQPPSPGGLP----VSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEA----AGAP 338

Query: 344 ALPAPPA-PPGSQPFLQKKRHGRPG 367
              A      G +   +    G PG
Sbjct: 339 VRGAGDTDEEGEEDAFEDAPRGSPG 363


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score =  139 bits (351), Expect = 4e-33
 Identities = 137/451 (30%), Positives = 171/451 (37%), Gaps = 75/451 (16%)

Query: 1   MPVPPPPPPPLPPP---PPPLGAPPP----PPPSAPPVSTDTSSLRRADPKGRSALLADI 53
           +P PP  PP   PP    PP+ APP     PP   P   T  S      P   S+L A  
Sbjct: 357 LPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATT 416

Query: 54  QQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAG 113
             G+   + T      +P+   +  T+        +R ASTPP    L A   P+  PA 
Sbjct: 417 SLGSPTLQATHSFLTMSPRQTQASLTSP-------SRPASTPPDSPPLQA---PLSLPAS 466

Query: 114 QRDVAGGKTGQGPGS--------------RAPSPRLPNKTISGPLIPPASPRLGNTSEAH 159
                       P S               + SP+ P  ++  P +   S     + +  
Sbjct: 467 PPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTP 526

Query: 160 GAARTAPPRPNVP--APPP--------PTPPPPPPPLPPPLPSSSPIKTPLVSPP--GPL 207
            A+ T PP  N+P  APPP         TP    PP P P P  +P  +PL +PP   P 
Sbjct: 527 PASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAP-PSPLTTPPPETPS 585

Query: 208 TKGNLPVVAPPVPCAP-----PPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPP 262
           +    P  APP   +P     P PP  P  TPPP  P  +         L PL  PP PP
Sbjct: 586 SIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXL--------ALPPLQAPPSPP 637

Query: 263 PLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLP------------- 309
             P L P   P  +A  A      Q P +PPP  P  A  SP AS P             
Sbjct: 638 ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPP 697

Query: 310 ---APPLPGVNSSSETPPPLPPKSPSFQAPPQKAG--AQALPAPPAPPGSQPFLQKKRHG 364
              APPL    S   +PP  P  +P  QAPP  A    Q  P+PPA P   P        
Sbjct: 698 SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRV 757

Query: 365 RPGAGGGKLNPPPAPPARSPTTELSSKSQQA 395
            P      L  PP+PPA  P + L+    QA
Sbjct: 758 PPLLAAPPLQVPPSPPASLPMSPLAKPPPQA 788



 Score =  138 bits (347), Expect = 1e-32
 Identities = 158/513 (30%), Positives = 207/513 (40%), Gaps = 82/513 (15%)

Query: 5   PPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQ 64
           P  P   PP  PPL AP   P S PP+ T  S      P      +  +Q  + L   + 
Sbjct: 444 PSRPASTPPDSPPLQAPLSLPAS-PPLQTSLSPA--VSPLSSPLTIHPLQALSSLASHSP 500

Query: 65  INDRSAPQIESSKGTNKEGGGSANTRGAS-TPPTLGDLFAGGFPVLRPAGQRDVAGGKTG 123
               S+  +   +  +     S  T  AS T P L +L     P L P   +  +   T 
Sbjct: 501 QAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENL-----PSLAPPPLQTASAPLTT 555

Query: 124 ---QGPGSRAPSP-RLPNKTISGPLIPPASPRLGNTSEAHGA-ARTAPPRPNVPAPPPP- 177
              + P   AP P + P   ++ P  PP +P    T       A  +PP   +P+PP   
Sbjct: 556 PHLETPPCPAPCPLQAPPSPLTTP--PPETPSSIATPPPQAPPALASPPLQGLPSPPLSP 613

Query: 178 --TPPPPPPP---LPP----PLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPP 228
             TPPP  PP   LPP    P P +SP  +PL +P  P     L V     P +PPP PP
Sbjct: 614 LATPPPQAPPXLALPPLQAPPSPPASPPLSPLATP-SPQAPNALAVHLLQAPFSPPPSPP 672

Query: 229 PP----PPTPPPLPPASVLSDKAVKPQLA--PLHLPPIPPPLPLLPPCGYPGLKAEPASP 282
                 PP  PP+ P++    +A  P LA  PL +PP PP  P + P   P  +A P   
Sbjct: 673 VQAPFSPPASPPVSPSATPPSQA-PPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLA 731

Query: 283 AQDAQEPPAPP--PPLPPYASCSPRAS--LPAPPLPGVNSSSETPPPLPPKSPSFQAPPQ 338
           A   Q PP+PP  PP+ P A+  PR    L APPL    S   + P  P   P  QAPP 
Sbjct: 732 APPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPA 791

Query: 339 KA--GAQALPAPPAP-PGSQPFLQKKR-----------HGRPGAGGGKLNPPPAPPARSP 384
            A    QALP+PPA  PG  PF                   P      L  PP+PPA SP
Sbjct: 792 LATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPA-SP 850

Query: 385 TTELSSKSQQATAWTPTQQPGGQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYKPCQKIY 444
           T        QA    PT  P   +    L +           ++   PPP          
Sbjct: 851 TL-------QAPRRPPTPGPDTSVSGPRLTL-----------ALAPGPPPP--------- 883

Query: 445 PSKIPRSRTPGPWLQAEAVGQSS--DDIKGRNS 475
           PS+ P S   GP L   +   +S  ++++G +S
Sbjct: 884 PSRSPSSTLSGPDLAGHSSSATSTPEELRGYDS 916



 Score =  124 bits (311), Expect = 2e-28
 Identities = 128/421 (30%), Positives = 156/421 (37%), Gaps = 97/421 (23%)

Query: 1   MPVPPPPPPPLPPP--PPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTR 58
           +P PP  P   PPP  PP L  PP   P +PP S   S L    P+  +AL   + Q   
Sbjct: 606 LPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ--- 662

Query: 59  LRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVA 118
                                       A      +PP          P + P+      
Sbjct: 663 ----------------------------APFSPPPSPPVQAPFSPPASPPVSPSAT---- 690

Query: 119 GGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAA---RTAPP---RPNVP 172
                  P S+AP P L    +  P  PPASP +  ++     A     APP    P+ P
Sbjct: 691 -------PPSQAP-PSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPP 742

Query: 173 APPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPP 232
           A PP +P   PPP  PPL ++ P++ P  SPP  L         P  P A PPP  PP  
Sbjct: 743 ASPPMSPSATPPPRVPPLLAAPPLQVP-PSPPASL---------PMSPLAKPPPQAPPAL 792

Query: 233 TPPPL-----PPASVLSDKAVKPQLAPLHLPPIPPPLPLLPP-CGYPGLKAEPASPAQDA 286
             PPL     PPAS        P  A L + P+  P P  PP    P L+  P+ PA   
Sbjct: 793 ATPPLQALPSPPASFPGQAPFSPS-ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPT 851

Query: 287 -QEPPAPPPPLPPYASCSPRASL---PAPPLPGVNSSSET--PPPLPPKSPSFQAPPQ-- 338
            Q P  PP P P  +   PR +L   P PP P   S S T   P L   S S  + P+  
Sbjct: 852 LQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEEL 911

Query: 339 -------KAGAQALPAP--------PAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARS 383
                  + GA A P P        PA     P       G PGA      P P PPA  
Sbjct: 912 RGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGA------PLPWPPATG 965

Query: 384 P 384
           P
Sbjct: 966 P 966



 Score =  109 bits (273), Expect = 5e-24
 Identities = 140/514 (27%), Positives = 179/514 (34%), Gaps = 122/514 (23%)

Query: 6   PPPPPLPPPPPPLGAPPPPPPSAPPVST-DTSSLRRADPKGRSALLADIQQGTRLRKVTQ 64
           P P P   P PP   P     SA   ST + S   R  P     L     +       T 
Sbjct: 190 PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS-SSATP 248

Query: 65  IND--RSAPQIESSKGTNKEGGGSANTRG----ASTPPTLGDLFAGGFPVLRPAGQRDVA 118
           ++   RS P   S++GT +     +  +     A  PP +        P L P     +A
Sbjct: 249 LSSPARSGP---SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLA 305

Query: 119 GGKTGQGPGSRA-PSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPR----PNVPA 173
              T    G++A P P   N     P   P SP L         + +APP     P+ PA
Sbjct: 306 ---TPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPA 362

Query: 174 PPPPTPPP----PPPPLPPPLPSSSPIKTP-------LVSPPGPLTKGNLP--------- 213
            PP   PP    PP   PP L +  PI+ P       L +PP PL   +L          
Sbjct: 363 TPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPT 422

Query: 214 ------------------VVAPPVPCAPPPPPPP--PPPTPPPLPPASVLSDKAVKPQLA 253
                             + +P  P + PP  PP   P + P  PP       AV P  +
Sbjct: 423 LQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSS 482

Query: 254 PLHLPP-------------------IPPPLPLLPPCGYPGLKAEPASPAQDAQE--PPAP 292
           PL + P                   I PPL        P L+  PAS      E  P   
Sbjct: 483 PLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLA 542

Query: 293 PPPL--------------PPYASCSPRASLPAP---PLPGVNSSSETPP----------- 324
           PPPL              PP  +  P  + P+P   P P   SS  TPP           
Sbjct: 543 PPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPP 602

Query: 325 ----PLPPKSPSFQAPPQKAGAQALP---APPAPPGSQPF--LQKKRHGRPGAGGGKL-- 373
               P PP SP    PPQ     ALP   APP+PP S P   L       P A    L  
Sbjct: 603 LQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ 662

Query: 374 ---NPPPAPPARSPTTELSSKSQQATAWTPTQQP 404
              +PPP+PP ++P +  +S     +A  P+Q P
Sbjct: 663 APFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP 696



 Score =  103 bits (256), Expect = 5e-22
 Identities = 143/461 (31%), Positives = 165/461 (35%), Gaps = 103/461 (22%)

Query: 4   PPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVT 63
           P    P L  P PP G+P PPPP  P        L  A   GR   LA+   G     + 
Sbjct: 17  PAARAPGLLTPRPP-GSPRPPPPVTPAA---LRVLGAAGAVGRKP-LAERAGGIGGATIP 71

Query: 64  QINDRSAPQIESSKGTNKEGGGS---ANTRGASTPP--------------TLGDLFAG-- 104
           +   R+ P    S GT+     S   A+ RG   PP                G    G  
Sbjct: 72  ESAPRAGP--TRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL 129

Query: 105 GFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAART 164
           G   LR + +  VA GK  + P   A S      T SGP     SP +   S A G    
Sbjct: 130 GQKGLRISAEETVARGKATEAPKRSALSAGARRDT-SGPTPGTPSPAMARRSRAAG-TEV 187

Query: 165 APPRPNVPA-PPPPTPPP-------------PPPPLPPPLPSS------------SPIKT 198
             PRP   A P PPT  P              P P     PS+            S   T
Sbjct: 188 GLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSAT 247

Query: 199 PLVSP--PGPLTKGNLPVVAPPVPCAPPPPPP-------PPPPTPPPLPPASVLSDKAVK 249
           PL SP   GP  +G      P  P  P  P P       PP  TPP          K   
Sbjct: 248 PLSSPARSGPSARG-----TPRAPAHPSQPKPKGLQALRPPQVTPP---------RKDAA 293

Query: 250 PQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEP-PAPPPPLPPYASCSPRASL 308
           P L PL   P+  P P        G KA P  P  +A  P PA  PP PP A+  P    
Sbjct: 294 PALGPLSSSPLATPSP-------SGTKARPVPPPDNAATPLPATLPPSPPLATPLPL--- 343

Query: 309 PAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQ--PFLQKKRHGRP 366
            APP P    S +T P  PP +P  QAPP    +   P   APP  Q  P +Q       
Sbjct: 344 -APPSPSAPPSLQTLPS-PPATPPSQAPP----SMTTPPMQAPPSLQTIPPIQVPH---- 393

Query: 367 GAGGGKLNPPPAPPARS---PTTELSSKSQQATAWTPTQQP 404
                 L  PP+P A S    TT L S + QAT    T  P
Sbjct: 394 SLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSP 434



 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 112/408 (27%), Positives = 145/408 (35%), Gaps = 67/408 (16%)

Query: 2   PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRK 61
           P   PP        PP     P P S+P  ++ T+   R  P G+  L    ++     K
Sbjct: 90  PASRPPASGRGERAPPAKNTSPGPVSSPGRASGTT---RPGPLGQKGLRISAEETVARGK 146

Query: 62  VTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGK 121
            T+   RSA     S G  ++  G   T G  +P       A G  V  P          
Sbjct: 147 ATEAPKRSA----LSAGARRDTSGP--TPGTPSPAMARRSRAAGTEVGLPRPAPSARPRP 200

Query: 122 TGQGP----------GSRAPSPRLPNK-TISGPLIPPASPRLGNTSEAHGA-ARTAPPRP 169
             +GP           +  PSP    + +  G L  PAS  L +++    + AR+ P   
Sbjct: 201 PTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSAR 260

Query: 170 NVP-APPPPTPPPP-------PPPLPPPLPSSSPIKTPLVSPP----GPLTKGNLPVVAP 217
             P AP  P+ P P       PP + PP   ++P   PL S P     P      PV  P
Sbjct: 261 GTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPP 320

Query: 218 PVPCAPPP---PPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPG 274
                P P   PP PP  TP PL P S     +  P L  L  PP  PP    P    P 
Sbjct: 321 DNAATPLPATLPPSPPLATPLPLAPPS----PSAPPSLQTLPSPPATPPSQAPPSMTTPP 376

Query: 275 LKAEPASPAQDAQEPP---------APPPPLPPYASCSPRASLPAPPLPGVNS------- 318
           ++A P+       + P         APP PL   +S     SL +P L   +S       
Sbjct: 377 MQAPPSLQTIPPIQVPHSLTSPSLQAPPSPL-ALSSLQATTSLGSPTLQATHSFLTMSPR 435

Query: 319 -------SSETPPPLPPKSPSFQAP---PQKAGAQALPAPPAPPGSQP 356
                  S   P   PP SP  QAP   P     Q   +P   P S P
Sbjct: 436 QTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSP 483



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 99/379 (26%), Positives = 128/379 (33%), Gaps = 82/379 (21%)

Query: 76  SKGTNKEGGGSANTRGASTPPTLGDLFAGGF---PVLRPAGQRDV-AGGKTGQGP-GSRA 130
           +K    + G +A T  A  P  L     G     P + PA  R + A G  G+ P   RA
Sbjct: 3   NKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERA 62

Query: 131 PSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPL 190
                    I G  IP ++PR G T  A  ++R    RP  PA       PP     P  
Sbjct: 63  GG-------IGGATIPESAPRAGPTRSAGTSSRNPASRP--PASGRGERAPPAKNTSPG- 112

Query: 191 PSSSPIKTPLVSPPGPLTKGNLPVVAP---------------------------PVPCAP 223
           P SSP +    + PGPL +  L + A                            P P  P
Sbjct: 113 PVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP 172

Query: 224 PPPP-------------PPPPPTPPPLPP--------ASVLSDKAVKPQLAPLHLPPIPP 262
            P               P P P+  P PP        +S       +P  A    P    
Sbjct: 173 SPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG 232

Query: 263 PL-------------PLLPPC-GYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASL 308
            L             PL  P    P  +  P +PA  +Q  P     L P     PR   
Sbjct: 233 GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKD- 291

Query: 309 PAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPA--PPAPPGSQPF-LQKKRHGR 365
            A P  G  SSS    P P  + +   PP    A  LPA  PP+PP + P  L       
Sbjct: 292 -AAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSA 350

Query: 366 PGAGGGKLNPPPAPPARSP 384
           P +     +PP  PP+++P
Sbjct: 351 PPSLQTLPSPPATPPSQAP 369



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 96/343 (27%), Positives = 117/343 (34%), Gaps = 82/343 (23%)

Query: 1    MPVPPPPP--PPL-----PPP--PPPLGAPP----PPPPSAPPVSTDTSSLRRADPKGRS 47
            + VPP PP  PP+     PPP  PPPL APP    P PP++PP+S   +   R  P   +
Sbjct: 704  LQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAA 763

Query: 48   ALLADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANT--RGASTPPTLGDLFAGG 105
              L          +V      S P    +K   +     A    +   +PP     F G 
Sbjct: 764  PPL----------QVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPAS---FPGQ 810

Query: 106  FPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTA 165
             P   P+    ++   T   P  +AP P L    +  P  PPASP L            A
Sbjct: 811  AP-FSPSASLPMSPLAT---PPPQAP-PVLAAPLLQVPPSPPASPTL-----------QA 854

Query: 166  PPRPNVPAPPP------------PTPPPPPPPLP------PPLP--SSSPIKTP-----L 200
            P RP  P P              P PPPPP   P      P L   SSS   TP      
Sbjct: 855  PRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGY 914

Query: 201  VSPPGPLTKGNLPVVAPPVPC-------APPPP------PPPPPPTPPPLPPASVLSDKA 247
             S P      + P  A    C        P PP      P  P P PP   P S      
Sbjct: 915  DSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCT 974

Query: 248  VKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPP 290
            +     P    P P  L   P  G  G KA   + A  +   P
Sbjct: 975  IYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSP 1017



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 63/252 (25%), Positives = 97/252 (38%), Gaps = 19/252 (7%)

Query: 156 SEAHGAARTAPPR-PNVPAPPPPTPPPPPPPLPPP----LPSSSPI-KTPLVSPPGPLTK 209
           ++A  AART   R P +  P PP  P PPPP+ P     L ++  + + PL    G +  
Sbjct: 8   AKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGG 67

Query: 210 GNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDK---AVKPQLAPLHLPPIPPPLPL 266
             +P  AP     P          P   PPAS   ++   A      P+  P        
Sbjct: 68  ATIPESAP--RAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTR 125

Query: 267 LPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYA----SCSPRASLPAPPLPGVNSSSET 322
             P G  GL+          +   AP            +  P    P+P +   + ++ T
Sbjct: 126 PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGT 185

Query: 323 PPPLPPKSPSFQ-APPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPA 381
              LP  +PS +  PP +   +++ +      ++P    +R  RP AGGG L  P +   
Sbjct: 186 EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR--RPSAGGG-LQRPASRSL 242

Query: 382 RSPTTELSSKSQ 393
            S  T LSS ++
Sbjct: 243 SSSATPLSSPAR 254


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score =  138 bits (347), Expect = 1e-32
 Identities = 134/432 (31%), Positives = 179/432 (41%), Gaps = 49/432 (11%)

Query: 11  LPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSA 70
           LP P P   A P PP   P  S  ++S         +A       G   R  ++    SA
Sbjct: 180 LPRPAP--SARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSA 237

Query: 71  PQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAG--GKTGQGPGS 128
             + S   +     G+       + P    L A   P + P  ++D A   G     P +
Sbjct: 238 TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPP-RKDAAPALGPLSSSPLA 296

Query: 129 RAPSPRLPNKTISGPLI-----PPASP------RLGN-TSEAHGAARTAPPRPNVPAPPP 176
             PSP  P    + P +     PPA+P       LG+ T +A  +   +PP   +  PPP
Sbjct: 297 -TPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPP 355

Query: 177 PTPPPP--PPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPP---- 230
             PP    PP   PP P +SP  +PL +P  P     L V     P +PPP PP      
Sbjct: 356 QAPPALALPPLQAPPSPPASPPLSPLATP-SPQAPNALAVHLLQAPFSPPPSPPVQAPFS 414

Query: 231 PPTPPPLPPASVLSDKAVKPQLA--PLHLPPIPPPLPLLPPCGYPGLKAEP---ASPAQD 285
           PP  PP+ P++    +A  P LA  PL +PP PP  P + P   P  +A P   A P Q 
Sbjct: 415 PPASPPVSPSATPPSQA-PPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQL 473

Query: 286 AQEPPAPPPPLPPYASCSPRASLPAPP--LPGVN--SSSETPPPLPPKSPSFQAPPQKAG 341
           A+    PPP  PP  +  P  +LP+PP   PG    S S + P  P  +P  QAPP  A 
Sbjct: 474 AK----PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLA- 528

Query: 342 AQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNP---------PPAPPARSPTTELSSKS 392
           A  L  PP+PP S      +R   PG       P         PP PP+RSP++ LS   
Sbjct: 529 APLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPD 588

Query: 393 QQATAWTPTQQP 404
               + + T  P
Sbjct: 589 LAGHSSSATSTP 600



 Score =  112 bits (281), Expect = 6e-25
 Identities = 125/416 (30%), Positives = 156/416 (37%), Gaps = 84/416 (20%)

Query: 1   MPVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLR 60
           +  P P  PP P  PP L   P PP  A P S  T+SL     +   + L        L 
Sbjct: 295 LATPSPSAPPSPSAPPSLQTLPSPP--ATPPSQATTSLGSPTLQATHSFL----PSPPLS 348

Query: 61  KVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQR-DVAG 119
            +     ++ P +                +   +PP    L     P+  P+ Q  +   
Sbjct: 349 PLATPPPQAPPAL-----------ALPPLQAPPSPPASPPL----SPLATPSPQAPNALA 393

Query: 120 GKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVP--APPPP 177
               Q P S  PSP      +  P  PPASP +  ++         PP    P  A PP 
Sbjct: 394 VHLLQAPFSPPPSP-----PVQAPFSPPASPPVSPSA--------TPPSQAPPSLAAPPL 440

Query: 178 TPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPL 237
             PP PP  PP  PS++P   P  +PP        P+ APP+  A PPP  PP    PPL
Sbjct: 441 QVPPSPPASPPMSPSATP---PPQAPP--------PLAAPPLQLAKPPPQAPPALATPPL 489

Query: 238 -----PPASVLSDKAVKPQLAPLHLPPIPPPLPLLPP-CGYPGLKAEPASPAQDA-QEPP 290
                PPAS        P  A L + P+  P P  PP    P L+  P+ PA    Q P 
Sbjct: 490 QALPSPPASFPGQAPFSPS-ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPR 548

Query: 291 APPPPLPPYASCSPRASL---PAPPLPGVNSSSET--PPPLPPKSPSFQAPPQ------- 338
            PP P P  +   PR +L   P PP P   S S T   P L   S S  + P+       
Sbjct: 549 RPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDS 608

Query: 339 --KAGAQALPAP--------PAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP 384
             + GA A P P        PA     P       G PGA      P P PPA  P
Sbjct: 609 GPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGA------PLPWPPATGP 658



 Score =  110 bits (275), Expect = 3e-24
 Identities = 138/487 (28%), Positives = 170/487 (34%), Gaps = 118/487 (24%)

Query: 4   PPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVT 63
           P    P L  P PP G+P PPPP  P        L  A   GR   LA+   G     + 
Sbjct: 17  PAARAPGLLTPRPP-GSPRPPPPVTPAA---LRVLGAAGAVGRKP-LAERAGGIGGATIP 71

Query: 64  QINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQR-------- 115
           +   R+ P   S    +  G  +   +  S  P      A G     P GQ+        
Sbjct: 72  ESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEE 131

Query: 116 DVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGA-------ARTAPPR 168
            VA GK  + P   A S      T SGP     SP +   S A G        A +A PR
Sbjct: 132 TVARGKATEAPKRSALSAGARRDT-SGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPR 190

Query: 169 PNVPAP--------------PPP------------------------TPPPPP------- 183
           P    P              P P                        TP   P       
Sbjct: 191 PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSA 250

Query: 184 --PPLPPPLPSS------SPIKTPLVSPP--------GPLTKGNLPVVAPPVPCAPPPPP 227
              P  P  PS         ++ P V+PP        GPL+   L   A P P APP P 
Sbjct: 251 RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPL---ATPSPSAPPSPS 307

Query: 228 PPPP----PTPPPLPPASVLSDKAVKPQLAPLH-------LPPIPPPLPLLPPC-GYPGL 275
            PP     P+PP  PP+   +     P L   H       L P+  P P  PP    P L
Sbjct: 308 APPSLQTLPSPPATPPSQATTSLG-SPTLQATHSFLPSPPLSPLATPPPQAPPALALPPL 366

Query: 276 KAEPASPAQDAQEPPAPPPPLPPYASC-----SPRASLPAPPLPGVNSSSETPPPLPPKS 330
           +A P+ PA     P A P P  P A       +P +  P+PP+    S   +PP  P  +
Sbjct: 367 QAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT 426

Query: 331 PSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPP--APPARSPTTEL 388
           P  QAPP  A A  L  PP+PP S P         P A      PPP   PP  +P  +L
Sbjct: 427 PPSQAPPSLA-APPLQVPPSPPASPPM-------SPSA-----TPPPQAPPPLAAPPLQL 473

Query: 389 SSKSQQA 395
           +    QA
Sbjct: 474 AKPPPQA 480



 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 105/429 (24%), Positives = 135/429 (31%), Gaps = 138/429 (32%)

Query: 114 QRDVA-GGKTGQGPGSRAP---SPRLPNKTISGPLIPPASPR------------------ 151
           +RD A  G   + P +RAP   +PR P      P + PA+ R                  
Sbjct: 4   KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAG 63

Query: 152 -LGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKG 210
            +G  +    A R  P R + P         PP     P P SSP +    + PGPL + 
Sbjct: 64  GIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQK 123

Query: 211 NLPVVAP---------------------------PVPCAPPPPP-------------PPP 230
            L + A                            P P  P P               P P
Sbjct: 124 GLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRP 183

Query: 231 PPTPPPLPP--------ASVLSDKAVKPQLAPLHLPPIPPPL-------------PLLPP 269
            P+  P PP        +S       +P  A    P     L             PL  P
Sbjct: 184 APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 243

Query: 270 C-GYPGLKAEPASPAQDAQEPP------APPPPLPPYASCSP-----------RASLPAP 311
               P  +  P +PA  +Q  P       PP   PP    +P             S  AP
Sbjct: 244 ARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAP 303

Query: 312 PLPGVNSSSETPP--------------------------PLPPKSPSFQAPPQKAGAQAL 345
           P P    S +T P                          P PP SP    PPQ   A AL
Sbjct: 304 PSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALAL 363

Query: 346 P---APPAPPGSQPF--LQKKRHGRPGAGGGKL-----NPPPAPPARSPTTELSSKSQQA 395
           P   APP+PP S P   L       P A    L     +PPP+PP ++P +  +S     
Sbjct: 364 PPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSP 423

Query: 396 TAWTPTQQP 404
           +A  P+Q P
Sbjct: 424 SATPPSQAP 432



 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 105/405 (25%), Positives = 130/405 (32%), Gaps = 122/405 (30%)

Query: 1   MPVPPPPPPPLPPPPPPLGAPPPPPPSA-PPVSTDTSSLRRADPKGRSALLADIQQGTRL 59
           +  PP   PP PP  PP+     PPP A PP++     L +  P+   AL          
Sbjct: 435 LAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPAL---------- 484

Query: 60  RKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAG 119
                    + P +++                  +PP         FP            
Sbjct: 485 ---------ATPPLQA----------------LPSPP-------ASFP------------ 500

Query: 120 GKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTP 179
              GQ P S  PS  LP   ++ P  PP +P +            A P   VP  PP +P
Sbjct: 501 ---GQAPFS--PSASLPMSPLATP--PPQAPPV-----------LAAPLLQVPPSPPASP 542

Query: 180 PPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPP 239
               P  PP               PGP T     V  P +  A  P PPPPP       P
Sbjct: 543 TLQAPRRPP--------------TPGPDTS----VSGPRLTLALAPGPPPPPSR----SP 580

Query: 240 ASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPY 299
           +S LS     P LA         P  L       G  + P   A       A PPP    
Sbjct: 581 SSTLSG----PDLAGHSSSATSTPEEL------RGYDSGPEGGA------AASPPPDAEL 624

Query: 300 ASCSPRA--SLPAPPLPGVNSSSETPPPLPPKSPSFQAP------PQKAGAQALPAPPA- 350
           A+C P A    PAPPL     +   P P PP +    A         +    A PAP A 
Sbjct: 625 AACHPAAWSRGPAPPL-AFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGAL 683

Query: 351 PPGSQPFLQ-KKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQ 394
            PG  P     K     GAG    +P  A     P   L +   Q
Sbjct: 684 DPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQ 728


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score =  131 bits (329), Expect = 2e-30
 Identities = 135/461 (29%), Positives = 177/461 (38%), Gaps = 77/461 (16%)

Query: 11  LPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSA 70
           LP P P   A P PP   P  S  ++S         +A       G   R  ++    SA
Sbjct: 189 LPRPAP--SARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSA 246

Query: 71  PQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAG--GKTGQGPGS 128
             + S   +     G+       + P    L A   P + P  ++D A   G     P +
Sbjct: 247 TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPP-RKDAAPALGPLSSSPLA 305

Query: 129 RAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPA-----PPPPTPPP-- 181
             PSP    ++ + P +P        T +       APP P+ P      P PP  PP  
Sbjct: 306 -TPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQ 364

Query: 182 -----------------PPPPLPP---PLPSSSPIKT--PLVSPPGPLTKGNLPVVAPPV 219
                            P PPL P   P P + P     PL +PP P     L  +A P 
Sbjct: 365 ATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPS 424

Query: 220 PCAP-------------PPPPPP-----PPPTPPPLPPASVLSDKAVKPQLA--PLHLPP 259
           P AP             PPP PP      PP  PP+ P++    +A  P LA  PL +PP
Sbjct: 425 PQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQA-PPSLAAPPLQVPP 483

Query: 260 IPPPLPLLPPCGYPGLKAEP---ASPAQDAQEPPAPPPPLPPYASCSPRASLPAPP--LP 314
            PP  P + P   P  +A P   A P Q A+    PPP  PP  +  P  +LP+PP   P
Sbjct: 484 SPPASPPMSPSATPPPQAPPPLAAPPLQLAK----PPPQAPPALATPPLQALPSPPASFP 539

Query: 315 GVN--SSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGK 372
           G    S S + P  P  +P  QAPP  A A  L  PP+PP S      +R   PG     
Sbjct: 540 GQAPFSPSASLPMSPLATPPPQAPPVLA-APLLQVPPSPPASPTLQAPRRPPTPGPDTSV 598

Query: 373 LNP---------PPAPPARSPTTELSSKSQQATAWTPTQQP 404
             P         PP PP+RSP++ LS       + + T  P
Sbjct: 599 SGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTP 639



 Score =  111 bits (277), Expect = 2e-24
 Identities = 125/416 (30%), Positives = 156/416 (37%), Gaps = 84/416 (20%)

Query: 1   MPVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLR 60
           +  P P  PP P  PP L   P PP  A P S  T+SL     +   + L        L 
Sbjct: 334 LATPLPLAPPSPSAPPSLQTLPSPP--ATPPSQATTSLGSPTLQATHSFL----PSPPLS 387

Query: 61  KVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQR-DVAG 119
            +     ++ P +                +   +PP    L     P+  P+ Q  +   
Sbjct: 388 PLATPPPQAPPAL-----------ALPPLQAPPSPPASPPL----SPLATPSPQAPNALA 432

Query: 120 GKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVP--APPPP 177
               Q P S  PSP      +  P  PPASP +  ++         PP    P  A PP 
Sbjct: 433 VHLLQAPFSPPPSP-----PVQAPFSPPASPPVSPSA--------TPPSQAPPSLAAPPL 479

Query: 178 TPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPL 237
             PP PP  PP  PS++P   P  +PP        P+ APP+  A PPP  PP    PPL
Sbjct: 480 QVPPSPPASPPMSPSATP---PPQAPP--------PLAAPPLQLAKPPPQAPPALATPPL 528

Query: 238 -----PPASVLSDKAVKPQLAPLHLPPIPPPLPLLPP-CGYPGLKAEPASPAQDA-QEPP 290
                PPAS        P  A L + P+  P P  PP    P L+  P+ PA    Q P 
Sbjct: 529 QALPSPPASFPGQAPFSPS-ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPR 587

Query: 291 APPPPLPPYASCSPRASL---PAPPLPGVNSSSET--PPPLPPKSPSFQAPPQ------- 338
            PP P P  +   PR +L   P PP P   S S T   P L   S S  + P+       
Sbjct: 588 RPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDS 647

Query: 339 --KAGAQALPAP--------PAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP 384
             + GA A P P        PA     P       G PGA      P P PPA  P
Sbjct: 648 GPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGA------PLPWPPATGP 697



 Score =  105 bits (263), Expect = 7e-23
 Identities = 141/472 (29%), Positives = 172/472 (36%), Gaps = 88/472 (18%)

Query: 4   PPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVT 63
           P    P L  P PP G+P PPPP  P        L  A   GR   LA+   G     + 
Sbjct: 17  PAARAPGLLTPRPP-GSPRPPPPVTPAA---LRVLGAAGAVGRKP-LAERAGGIGGATIP 71

Query: 64  QINDRSAPQIESSKGTNKEGGGS---ANTRGASTPP--------------TLGDLFAG-- 104
           +   R+ P    S GT+     S   A+ RG   PP                G    G  
Sbjct: 72  ESAPRAGP--TRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL 129

Query: 105 GFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAART 164
           G   LR + +  VA GK  + P   A S      T SGP     SP +   S A G    
Sbjct: 130 GQKGLRISAEETVARGKATEAPKRSALSAGARRDT-SGPTPGTPSPAMARRSRAAG-TEV 187

Query: 165 APPRPNVPA-PPPPTPPP-------------PPPPLPPPLPSS------------SPIKT 198
             PRP   A P PPT  P              P P     PS+            S   T
Sbjct: 188 GLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSAT 247

Query: 199 PLVSP--PGPLTKGNLPVVAPPVPCAPPPPPP-------PPPPTPPPLPPASVLSDKAVK 249
           PL SP   GP  +G      P  P  P  P P       PP  TPP    A  L   +  
Sbjct: 248 PLSSPARSGPSARG-----TPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 302

Query: 250 PQLAPLHLPPI----PPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPP-----PLPPYA 300
           P   P     +    PP LP  P      L  + A+P   A   P+ PP     P PP  
Sbjct: 303 PLATPSPSAALQSQAPPTLPATPHSS--SLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT 360

Query: 301 SCS-PRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPF-- 357
             S    SL +P L   +S   +PP  P  +P  QAPP  A    L APP+PP S P   
Sbjct: 361 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALA-LPPLQAPPSPPASPPLSP 419

Query: 358 LQKKRHGRPGAGGGKL-----NPPPAPPARSPTTELSSKSQQATAWTPTQQP 404
           L       P A    L     +PPP+PP ++P +  +S     +A  P+Q P
Sbjct: 420 LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP 471



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 115/440 (26%), Positives = 144/440 (32%), Gaps = 135/440 (30%)

Query: 76  SKGTNKEGGGSANTRGASTPPTLGDLFAGGF---PVLRPAGQRDV-AGGKTGQGP-GSRA 130
           +K    + G +A T  A  P  L     G     P + PA  R + A G  G+ P   RA
Sbjct: 3   NKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERA 62

Query: 131 PSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPL 190
                    I G  IP ++PR G T  A  ++R    RP  PA       PP     P  
Sbjct: 63  GG-------IGGATIPESAPRAGPTRSAGTSSRNPASRP--PASGRGERAPPAKNTSPG- 112

Query: 191 PSSSPIKTPLVSPPGPLTKGNLPVVAP---------------------------PVPCAP 223
           P SSP +    + PGPL +  L + A                            P P  P
Sbjct: 113 PVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP 172

Query: 224 PP-----------------PPP---PPPPTPPPLPPASVLSD------------------ 245
            P                 P P   P PPT  P    S  S+                  
Sbjct: 173 SPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG 232

Query: 246 -------KAVKPQLAPLHLP----------PIPPPLPLLP-PCGYPGLKAEPASPAQDAQ 287
                  +++     PL  P          P  P  P  P P G   L+    +P +   
Sbjct: 233 GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDA 292

Query: 288 EPPAPPPPLPPYASCSPRASLPA---PPLPGVNSSSE------TPPPLPPKSPSFQAPPQ 338
            P   P    P A+ SP A+L +   P LP    SS       TP PL P SPS  APP 
Sbjct: 293 APALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPS--APP- 349

Query: 339 KAGAQALPAPPAPPGSQ-----------------------PFLQKKRHGRPGAGGGKLNP 375
               Q LP+PPA P SQ                       P         P      L  
Sbjct: 350 --SLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQA 407

Query: 376 PPAPPARSPTTELSSKSQQA 395
           PP+PPA  P + L++ S QA
Sbjct: 408 PPSPPASPPLSPLATPSPQA 427



 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 105/405 (25%), Positives = 130/405 (32%), Gaps = 122/405 (30%)

Query: 1   MPVPPPPPPPLPPPPPPLGAPPPPPPSA-PPVSTDTSSLRRADPKGRSALLADIQQGTRL 59
           +  PP   PP PP  PP+     PPP A PP++     L +  P+   AL          
Sbjct: 474 LAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPAL---------- 523

Query: 60  RKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAG 119
                    + P +++                  +PP         FP            
Sbjct: 524 ---------ATPPLQA----------------LPSPP-------ASFP------------ 539

Query: 120 GKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTP 179
              GQ P S  PS  LP   ++ P  PP +P +            A P   VP  PP +P
Sbjct: 540 ---GQAPFS--PSASLPMSPLATP--PPQAPPV-----------LAAPLLQVPPSPPASP 581

Query: 180 PPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPP 239
               P  PP               PGP T     V  P +  A  P PPPPP       P
Sbjct: 582 TLQAPRRPP--------------TPGPDTS----VSGPRLTLALAPGPPPPPSR----SP 619

Query: 240 ASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPY 299
           +S LS     P LA         P  L       G  + P   A       A PPP    
Sbjct: 620 SSTLSG----PDLAGHSSSATSTPEEL------RGYDSGPEGGA------AASPPPDAEL 663

Query: 300 ASCSPRA--SLPAPPLPGVNSSSETPPPLPPKSPSFQAP------PQKAGAQALPAPPA- 350
           A+C P A    PAPPL     +   P P PP +    A         +    A PAP A 
Sbjct: 664 AACHPAAWSRGPAPPL-AFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGAL 722

Query: 351 PPGSQPFLQ-KKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQ 394
            PG  P     K     GAG    +P  A     P   L +   Q
Sbjct: 723 DPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQ 767


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  128 bits (321), Expect = 1e-29
 Identities = 143/509 (28%), Positives = 175/509 (34%), Gaps = 98/509 (19%)

Query: 6    PPPPPLPPPPPPLGAPPPP---PPS--------------APPVSTDTSSLRRADPKGRSA 48
            P P  +P  P P GAP PP   PPS               PP +T  S      PKG  A
Sbjct: 925  PAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPS------PKGGPA 978

Query: 49   LLADIQQGTRLRKVTQINDRSAPQIESSKGT---------NKEGGGSAN--TRGASTPPT 97
              +     T     T  + +  P   S KG          + +G  +A    +GASTPP 
Sbjct: 979  TPSPKGAPTP-PAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPA 1037

Query: 98   LGDLFAGGFPVLRPAGQ-----------RDVAGGKTGQGPGSRAPSPRLPNKTISGPLIP 146
                   G P   P  +               G  T    G+  P    P     GP  P
Sbjct: 1038 ATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATP 1097

Query: 147  -----PASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLV 201
                 P  P     S   G A   PP    P  P  TPP P   L  P P  +P  TP  
Sbjct: 1098 SPKGAPMPPAATPPSPKGGLA--TPPHKGAPTTPAATPPSPKGGLATPPPKGAP-TTPAA 1154

Query: 202  SPPGPLTKGNL----PVVAPPVPCAPPPPP-----PPPPPTPPPLPPASVLSDKAVKPQL 252
            +PP P  KG L    P  AP  P A PP P      P P   P  P A+  S K      
Sbjct: 1155 TPPSP--KGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATP 1212

Query: 253  APLHLPPIPPPLPLLPPCGY--PGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPA 310
            +P   P  P   P  P  G   P  K  P +PA     P   P   PP  + +P A+ P 
Sbjct: 1213 SPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATP- 1271

Query: 311  PPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAP---PAPPGSQPFLQKKRHGRPG 367
               P +     TPP     +P+   PP   G  A   P   P PP + P   K   G P 
Sbjct: 1272 ---PSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPP 1328

Query: 368  AGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQPGGQLRNGSLHIIDDFESKFTFHS 427
              G      P PPA +P +   + +  AT  TP+ + G                  T  S
Sbjct: 1329 PKGA-----PTPPAVTPPSPKGTPTLPAT--TPSSKGGP-----------------TTPS 1364

Query: 428  VEDFPPPDEYKPCQKIYPSKIPRSRTPGP 456
             ++ P P    P  K  P+  P S   GP
Sbjct: 1365 SKEGPTPPAATPSHKGGPAMTPPSPKRGP 1393



 Score =  113 bits (283), Expect = 3e-25
 Identities = 121/431 (28%), Positives = 149/431 (34%), Gaps = 68/431 (15%)

Query: 4    PPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRAD-PKGRSALLADIQQGTRLRKV 62
            P PP P   P P  +    P   + PP  T T S+     PK   A  A  Q       +
Sbjct: 856  PTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQ--APALSM 913

Query: 63   TQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKT 122
            T  + + A    + KG       S + +GA TPP                     A    
Sbjct: 914  TSSSPKKARATPAPKGI----PASPSPKGAPTPP---------------------AATPP 948

Query: 123  GQGPGSRAPSPR-LPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRP-NVPAPPPPTPP 180
                G   PSP+  P    + P  P   P   +   A       PP P   PA P P   
Sbjct: 949  SPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGA 1008

Query: 181  PPPPPLPPPLPSSSPIKTPL---------VSPPGPLTKGN-----LPVVAPPVPCAPPPP 226
            P PP + PP P  SP  TP           +PP P  KG+     LP  AP  P A  P 
Sbjct: 1009 PTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSP--KGSPAATPLPKGAPTTPAATLPS 1066

Query: 227  PPPPPPTP----PPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEP--A 280
            P   P TP     P PPA+        P        P+PP     PP    GL   P   
Sbjct: 1067 PKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPP--AATPPSPKGGLATPPHKG 1124

Query: 281  SPAQDAQEPPAP----PPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAP 336
            +P   A  PP+P      P P  A  +P A+ P+P          TPPP    +     P
Sbjct: 1125 APTTPAATPPSPKGGLATPPPKGAPTTPAATPPSP-----KGGLATPPPKGAPTTPAATP 1179

Query: 337  PQKAGAQALPAP---PAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQ 393
            P   G  A P+P   P  P + P   K     P   G    P   PP  SP   L++ S 
Sbjct: 1180 PSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPP--SPKGGLATPSP 1237

Query: 394  QATAWTPTQQP 404
            +    TP   P
Sbjct: 1238 KGAPTTPAATP 1248



 Score =  111 bits (277), Expect = 2e-24
 Identities = 126/431 (29%), Positives = 156/431 (36%), Gaps = 49/431 (11%)

Query: 7    PPPPLPPPPPPLGAPPPPPPSA---PPVSTDTS---SLRRADPKGRSALLADIQQGTRLR 60
            P PP   PP P G P  P P     PP +T  S    L     KG     A      +  
Sbjct: 1080 PTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGG 1139

Query: 61   KVTQINDRSAPQIESSKGTNKEGG------GSANTRGASTPPTLGDLFAGGFPVLRPAGQ 114
              T    + AP   ++   + +GG        A T  A+TPP+      GG     P G 
Sbjct: 1140 LATP-PPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSP----KGGLATPSPKGA 1194

Query: 115  RDVAGGKTGQGPGSRA-PSPRLPNKTISGPLIPPASPRLG-NTSEAHGAARTAPPRPNVP 172
                        G  A PSP+    T   P   P SP+ G  T    GA  T    P  P
Sbjct: 1195 PTTPAATPPSPKGGLATPSPKGAPTT---PAATPPSPKGGLATPSPKGAPTTPAATPPSP 1251

Query: 173  APPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKG--NLPVVAPPVPCAPPPPPPPP 230
               P TPPP   P PP     S +K  L +PP    KG  N  VV PP P   P   PP 
Sbjct: 1252 KGGPATPPPKGAPTPPAATPPS-LKGGLATPPH---KGAPNPAVVTPPSPKGGPATSPPK 1307

Query: 231  -PPTPPPLPPASVLSDKAVKP----QLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQD 285
              PTPP   P S        P       P   PP P   P L P   P  K  P +P+  
Sbjct: 1308 GAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTL-PATTPSSKGGPTTPS-- 1364

Query: 286  AQEPPAPPPPLPPYASCSPRASLPAP------PLPGVNSSSETPPPLPPKSPSFQAPPQK 339
            ++E P PP   P +    P  + P+P      P P  + +S    PL PK        ++
Sbjct: 1365 SKEGPTPPAATPSHKG-GPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTRE 1423

Query: 340  AGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNP----PPAPPARSPTT--ELSSKSQ 393
              A        PP   P   KK        GG   P     P  PA +P +  E  +  Q
Sbjct: 1424 GAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQ 1483

Query: 394  QATAWTPTQQP 404
             AT+ +P + P
Sbjct: 1484 VATSSSPKKAP 1494



 Score =  110 bits (276), Expect = 2e-24
 Identities = 110/420 (26%), Positives = 156/420 (37%), Gaps = 54/420 (12%)

Query: 3    VPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKV 62
            V PP P   P   PP GAP PP  + P   +   S     PKG     A          V
Sbjct: 1292 VTPPSPKGGPATSPPKGAPTPPAATPP---SPKGSPGTPPPKGAPTPPA----------V 1338

Query: 63   TQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKT 122
            T  + +  P + ++  ++K G  + +++   TPP       GG  +  P+ +R  A    
Sbjct: 1339 TPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSP 1398

Query: 123  GQGPGSRAPSPRLPNKTISGP-------------LIPPA-SPRLGNTSEAHGAARTAPPR 168
               P S A  P  P K  + P             L PPA +P     + A  A +  P  
Sbjct: 1399 KGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPAT 1458

Query: 169  PNVPAPPPPTPPPPPPPLPPPLP-----SSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAP 223
            P+    P      PP P  PP P     SSSP K P  + P P+    LP V   +P +P
Sbjct: 1459 PSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAP--ATPAPMGAPTLPAV---IPSSP 1513

Query: 224  PPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPA 283
               P  P     P+ P + L  K     LAP     IPP + +  P   P +     +PA
Sbjct: 1514 KEVPATPSSRRDPIAPTATLLSKKTPATLAPKE-ALIPPAMTVPSPKKTPAIPTPKEAPA 1572

Query: 284  QDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQ 343
              + +  + PP + P    S     P+P    +  +  +P P    +P    PP      
Sbjct: 1573 TPSSKEASSPPAVTP----STYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGP 1628

Query: 344  ALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQ 403
            A PAP   P S P                L   P  PA S T ++ +   QA+   P ++
Sbjct: 1629 ATPAPKGTPTSPPVTP-----------SSLKDSPTSPA-SVTCKMGATVPQASKGLPAKK 1676



 Score =  109 bits (273), Expect = 5e-24
 Identities = 135/502 (26%), Positives = 165/502 (32%), Gaps = 107/502 (21%)

Query: 2    PVPPPPPPPLPPPPPPLGAPP----PPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGT 57
            PV P P     P    + AP      P PS PP  T   + ++ D    ++ LA +    
Sbjct: 709  PVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGT-KKVDGISHTSALAPVASSP 767

Query: 58   RLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGAST------PPT----------LGDL 101
               K     D  A    SSKGT      S +  G S       PPT          +G+L
Sbjct: 768  ---KECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNL 824

Query: 102  FAGGFPV---------LRPAGQRDVAGGKTGQGPGSR--APSPR-----------LPNKT 139
             +   PV         L   G +D         P S   AP+P            LP K 
Sbjct: 825  SSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKE 884

Query: 140  ISGPLI--------------PPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPP 185
               P +              P  +P L  TS +   AR  P    +PA P P   P PP 
Sbjct: 885  TPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPA 944

Query: 186  LPPPLPSSSPIKT--------PLVSPPGPLTKGN----LPVVAPPVPCAPPP-------- 225
              PP P   P           P  +PP P  KG      P  AP  P A PP        
Sbjct: 945  ATPPSPKGGPATPSPKWAPTPPAATPPSP--KGGPATPSPKGAPTPPAATPPSPKGGPAT 1002

Query: 226  --------PPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLP-------PIPPPLPLLPPC 270
                    PP   PP+P   P A+     A  P  A    P       P+P   P  P  
Sbjct: 1003 PSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAA 1062

Query: 271  GYPGLKAEPASPA-QDAQEPPAPPPPLPPYASCSPR-ASLPAPPL---PGVNSSSETPPP 325
              P  K  PA+P+ + A  PPA  PP P     +P     P PP    P       TPP 
Sbjct: 1063 TLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPH 1122

Query: 326  LPPKSPSFQAPPQKAGAQALPAP---PAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPAR 382
                +     PP   G  A P P   P  P + P   K     P   G    P   PP  
Sbjct: 1123 KGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPP-- 1180

Query: 383  SPTTELSSKSQQATAWTPTQQP 404
            SP   L++ S +    TP   P
Sbjct: 1181 SPKGGLATPSPKGAPTTPAATP 1202



 Score =  102 bits (254), Expect = 8e-22
 Identities = 128/499 (25%), Positives = 162/499 (32%), Gaps = 98/499 (19%)

Query: 2    PVPPPPPPPLPPPPPPLGAPPPPPPSAP--PVSTDTS---SLRRADPKGRSALLADIQQG 56
            P   P  P   PP P  G   PPP  AP  P +T  S    L    PKG     A     
Sbjct: 1145 PKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPS 1204

Query: 57   TRLRKVTQINDRSAPQIESSKGTNKEGG-GSANTRGASTPPTLGDLFAGGFPVLRP---A 112
             +    T  + + AP   ++   + +GG  + + +GA T P        G P   P   A
Sbjct: 1205 PKGGLATP-SPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGA 1263

Query: 113  GQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPN-V 171
                 A   + +G  +  P    PN  +  P  P   P       A       PP P   
Sbjct: 1264 PTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGS 1323

Query: 172  PAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPP---GPLTKGNLPVVAPPV--------P 220
            P  PPP   P PP + PP P  +P   P  +P    GP T  +     PP         P
Sbjct: 1324 PGTPPPKGAPTPPAVTPPSPKGTPT-LPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGP 1382

Query: 221  CAPPPPPPPPPPTPPP----------------LPPASVLSDKAVKPQLAPLHLPPIPP-- 262
               PP P   P  P P                 P   V  + A  P    L  P + P  
Sbjct: 1383 AMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVS 1442

Query: 263  ----PLPLLPPCG--YPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPR------ASLPA 310
                P    P  G   P  K +P  PA     P  PP P     S SP+      A + A
Sbjct: 1443 LKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGA 1502

Query: 311  PPLPGVNSSSETPPPLPP----------------KSPSFQAP-----------PQKAGAQ 343
            P LP V  SS    P  P                K+P+  AP           P      
Sbjct: 1503 PTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTP 1562

Query: 344  ALPAP---PAPPGSQ-----PFLQKKRHGRPGAGGGKLNPP----------PAPPARSPT 385
            A+P P   PA P S+     P +    +    +    L PP          P PPA +P 
Sbjct: 1563 AIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPP 1622

Query: 386  TELSSKSQQATAWTPTQQP 404
            +     +  A   TPT  P
Sbjct: 1623 SPEKGPATPAPKGTPTSPP 1641



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 124/485 (25%), Positives = 160/485 (32%), Gaps = 111/485 (22%)

Query: 2    PVPPPPPP-----PLPPPPPPLGAPPPPPPSAPPVSTDTSSLRR----ADPKGRSALLAD 52
            P PP   P     P   PP P   P  P P   P S     L      A P  R      
Sbjct: 1369 PTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATP 1428

Query: 53   IQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPA 112
             +       VT ++ + AP   + KG    G  + +++G  T P +        P   PA
Sbjct: 1429 SKGDLTPPAVTPVSLKKAPATSAPKG----GPATPSSKGDPTLPAV----TPPSPKEPPA 1480

Query: 113  GQRDVAGGKTGQGPGSRAP--SPRLPNKTISGPLIPPASPR------------LGNTSEA 158
             ++        + P + AP  +P LP    S P   PA+P             L   + A
Sbjct: 1481 PKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPA 1540

Query: 159  HGAARTA--PPRPNVPAPPP----PTPPPPP----------PP----------------- 185
              A + A  PP   VP+P      PTP   P          PP                 
Sbjct: 1541 TLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELL 1600

Query: 186  LPPPLPSSSPIKT---PLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPT--PPPLPPA 240
            +PP + S SP +    P V+PP P  KG     A P P   P  PP  P +    P  PA
Sbjct: 1601 IPPAVTSPSPKEAPTPPAVTPPSP-EKG----PATPAPKGTPTSPPVTPSSLKDSPTSPA 1655

Query: 241  SVLSDKAVKPQLAPLHLPP----------IPPPLPLLPPCGYPGLKAEPASPAQDAQEPP 290
            SV          A   LP           +  P P   P      +  P +    A  PP
Sbjct: 1656 SVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPP 1715

Query: 291  APPPPLPPYASCSPRASL-PAPPLPGVNSSSETPP----------PLPPKSPSFQAP--- 336
              P P     S  P +++ PAP LP    SS+T            PL P       P   
Sbjct: 1716 ICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTA 1775

Query: 337  ---------PQKAGAQALPAPPA----PPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARS 383
                     P+ A   A P+PP      P   P L  K+   P + G  L  P  P A +
Sbjct: 1776 AAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPA 1835

Query: 384  PTTEL 388
               EL
Sbjct: 1836 DEDEL 1840



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 118/466 (25%), Positives = 164/466 (35%), Gaps = 68/466 (14%)

Query: 1    MPVPPPPPPPLPP----------------PPPPLGAPPPPP--PSAPPVSTDTSSLRRAD 42
            +P   PP P  PP                 P P+GAP  P   PS+P     T S RR  
Sbjct: 1467 LPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDP 1526

Query: 43   PKGRSALLADIQQGTRLRKVTQINDR---SAPQIESSKGTNKEGGGSANTRGASTPPTLG 99
                + LL+     T   K   I       +P+   +  T KE   + +++ AS+PP + 
Sbjct: 1527 IAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVT 1586

Query: 100  DLFAGGFP----VLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTIS---GPLIPPASPRL 152
                 G P    +L P      +  +    P    PSP     T +    P  PP +P  
Sbjct: 1587 PSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSS 1646

Query: 153  GNTSEAHGAARTAPPRPNVPAPPPPTPPPP-PPPLPPPLPSSSPIKTPLVSPP---GPLT 208
               S    A+ T      VP      P    P  L   L + +P  TP+++ P   GP T
Sbjct: 1647 LKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQT 1706

Query: 209  KGNLPVVAPPVPCAPPPPP-----PPPPPTPPPLPPASVLSDKAVKPQLAPLHLP--PIP 261
            K +    +PP+ C  P        P     P PL P    S K  K + A  H P  P+ 
Sbjct: 1707 KKS-SATSPPI-CPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDAS-HSPKGPLA 1763

Query: 262  PP-----LPL--------LPPCGYPGLKAEPASPAQDAQEPPAPPPPLPP---YASCSPR 305
            PP      PL        LP      + A P SP       P+P P LPP   +   SP 
Sbjct: 1764 PPESKASTPLTAAAFEKVLPKPESASVSAAP-SPPVSLPLAPSPVPTLPPKQQFLPSSPG 1822

Query: 306  ASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAP-------PAPPGSQPFL 358
              L +P  P   +  +   PL P  P     P ++    +P P       P P   QP  
Sbjct: 1823 LVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPV- 1881

Query: 359  QKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQP 404
              K +   G         P    +  T   + ++Q A A    ++P
Sbjct: 1882 -TKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEP 1926



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 73/274 (26%), Positives = 91/274 (33%), Gaps = 65/274 (23%)

Query: 185 PLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPP------PLP 238
           PL P    + P+     +   PL      V+AP +P + P P  PP  TPP       + 
Sbjct: 699 PLVPTASENCPVAPSPQNTCAPLAT---LVLAPEIPKSVPSPSLPPAGTPPGTKKVDGIS 755

Query: 239 PASVLSDKAVKPQLAP----------------LHLPPIPPPL--PLLPPCGYPGLKAEPA 280
             S L+  A  P+  P                 +L   P PL   + P    P  K   A
Sbjct: 756 HTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSA 815

Query: 281 SPAQDAQEPPAPPPPLPPYASCSPRASL--------------PAPPLP-GVNSSSETPP- 324
            P  D        P  P  AS  P  SL              P PP P G  + S   P 
Sbjct: 816 GP--DTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPL 873

Query: 325 -----PLPPK---SPSFQAPPQKAGAQALPAPPAPP-----GSQPFLQKKRHGRPGAGGG 371
                 LPPK   +PS    P      A PAP   P      S P   KK    P   G 
Sbjct: 874 SPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSP---KKARATPAPKGI 930

Query: 372 KLNP----PPAPPARSPTTELSSKSQQATAWTPT 401
             +P     P PPA +P +     +  +  W PT
Sbjct: 931 PASPSPKGAPTPPAATPPSPKGGPATPSPKWAPT 964



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 65/243 (26%), Positives = 89/243 (36%), Gaps = 63/243 (25%)

Query: 168 RPNVPAPPPPTPPPPPPPLPP-----PLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCA 222
           +P    PPP +P P   PL       P PS S I +  +  P P +       A P+  A
Sbjct: 40  QPGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSG---TALPLGTA 96

Query: 223 PPPPPPPPPPTPPPLPPASV-LSDKAVKPQL-------APLHLPPI-----------PPP 263
           P  P   P    PP+ PA++ L+   + P L       APL L  +           PP 
Sbjct: 97  PEAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPN 156

Query: 264 LPLLPP------------CGYPGLKAEPAS-----PAQDAQEPPAPPPP-----LPPYAS 301
           L   PP               P   +EP +     P++    P   P P       PY  
Sbjct: 157 LLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHC 216

Query: 302 CSPRASLPAPPLPGVNSSSETPP--PLPPKSP--------SFQAPPQKAGAQALPAPPAP 351
            +P AS+ +    GV S  +T P   L   SP        S    PQ  G+ +L  P +P
Sbjct: 217 VTPMASIQS----GVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSP 272

Query: 352 PGS 354
           P +
Sbjct: 273 PAA 275



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 58/201 (28%), Positives = 69/201 (34%), Gaps = 22/201 (10%)

Query: 171 VPAPPPPTPPPPPPPLPPP------LPSSSPIK-TPLVSPPGPLTKGNLPVVAPPVPCAP 223
           +P     T P     LP P      LP SS +  T  +  PGP           P PC+P
Sbjct: 1   MPGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTL---------PPPCSP 51

Query: 224 PPP--PPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLP--PCGYPGLKAEP 279
            P   P        P P  S ++   ++    P        PL   P  P   P L   P
Sbjct: 52  APQQCPLSAANQASPFPSPSTIASTPLEVPF-PQSSSGTALPLGTAPEAPTFLPNLIGPP 110

Query: 280 ASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQK 339
            SPA  A   P   P L    S S   +L A     V  SS  PP L    PS  A  + 
Sbjct: 111 ISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSV-AVAES 169

Query: 340 AGAQALPAPPAPPGSQPFLQK 360
                L AP AP   +  L K
Sbjct: 170 GSVITLSAPIAPSEPKTNLNK 190



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 83/363 (22%), Positives = 118/363 (32%), Gaps = 58/363 (15%)

Query: 87  ANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISG---- 142
           A+  GA   P    L     P + P  Q       + Q   S    P  P  T++     
Sbjct: 537 ASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLG 596

Query: 143 ---PLIPPASPR---LGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPI 196
              P+  PAS     LG  S A      +   P+   P   +    P     PL S+ P 
Sbjct: 597 EPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPA 656

Query: 197 KTPLVSPPG-----------------------PLTKGNLPVVAPPVPCAPPPPPPPPPPT 233
                +  G                       P+ +G L  + P VP A    P  P P 
Sbjct: 657 GVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTL-PLVPTASENCPVAPSPQ 715

Query: 234 PPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGY-PGLKAEPASPAQDAQEPPAP 292
               P A+++    + P++      P   P P LPP G  PG K         A  P A 
Sbjct: 716 NTCAPLATLV----LAPEI------PKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVAS 765

Query: 293 PPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPK-SPSFQAPPQKAGAQALPAP--- 348
            P   P       AS  A     +   +++P PL    SP  + PP K G+     P   
Sbjct: 766 SPKECPTEDSG--ASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGN 823

Query: 349 ---PAPPGSQPFLQKKR---HGRPGAGGGKLNPPPAPPARSPT-TELSSKSQQATAWTPT 401
              P  P    FL +      G   +     +P P  P  +PT + ++  S +     P 
Sbjct: 824 LSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPK 883

Query: 402 QQP 404
           + P
Sbjct: 884 ETP 886



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 51/205 (24%), Positives = 69/205 (33%), Gaps = 19/205 (9%)

Query: 140 ISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTP 199
           ++ P+I P      ++S        AP      +  PP     PP +      S    + 
Sbjct: 118 LASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSA 177

Query: 200 LVSPPGPLTKGN-LPVVAPPVPCAPPPPPPPPPPTPPPL--PPASVLSDKAVKPQLAPLH 256
            ++P  P T  N +P    P P   P PP      P     P AS+ S  A  PQ  P  
Sbjct: 178 PIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTT 237

Query: 257 LPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGV 316
              I  P   +       +   P +P   + + P  PP            SL    LP V
Sbjct: 238 TLAIASPQ--VKDTTISSVLISPQNPGSLSLKGPVSPPAA---------LSLSTQSLPVV 286

Query: 317 NSSSET-----PPPLPPKSPSFQAP 336
            SS +T     PP  P    S  AP
Sbjct: 287 TSSQKTAGPNTPPDFPISLGSHLAP 311



 Score = 33.9 bits (76), Expect = 0.34
 Identities = 63/282 (22%), Positives = 94/282 (33%), Gaps = 38/282 (13%)

Query: 2   PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRK 61
           P  PPP  P  P   PL A     P   P +  ++ L    P+  S     +  GT    
Sbjct: 43  PTLPPPCSP-APQQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTALPL--GTAPEA 99

Query: 62  VTQINDRSAPQIESSK---GTNKEGGGSANTRGASTPPTLGDLF------AGGFPVLRPA 112
            T + +   P I  +     +         T  +S P  L  L       +  FP     
Sbjct: 100 PTFLPNLIGPPISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLT 159

Query: 113 GQRDVAGGKTGQGPGSRAPSP---------RLPNKTISGPLIPPASPRLGNTSEAHGAAR 163
               VA  ++G      AP           ++P++ +  P   P+ P + +T   H    
Sbjct: 160 SPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTP 219

Query: 164 TAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPP----- 218
            A  +  V A  P T P     +  P    + I + L+SP  P +      V+PP     
Sbjct: 220 MASIQSGV-ASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSL 278

Query: 219 ----VPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLH 256
               +P          P TPP  P        ++   LAPLH
Sbjct: 279 STQSLPVVTSSQKTAGPNTPPDFP-------ISLGSHLAPLH 313



 Score = 33.9 bits (76), Expect = 0.34
 Identities = 84/353 (23%), Positives = 124/353 (35%), Gaps = 60/353 (16%)

Query: 22  PPPPPSAPPVSTD-----TSSLRRADPK-------GRSALLADIQQGT----RLRKVTQI 65
           P  PP+A  +ST      TSS + A P           + LA + Q +    +L   T  
Sbjct: 269 PVSPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGP 328

Query: 66  NDRSAPQIESSKGTNKEGGGSANTRGASTPPT-----LGDLFAGGFPVLRPAGQR----- 115
           +  S P +++    +   G S  ++ +  PP      +       FPV+ P+  +     
Sbjct: 329 SALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTI 388

Query: 116 -----DVAGGKTGQGPGSRAPSPRL-----PNKTISGPLIP--PASPRLGNTSEAHGAAR 163
                  +G        S +P+  L     PN T   PL+   P S        + G   
Sbjct: 389 SSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVS--------SVGTTP 440

Query: 164 TAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAP 223
                P   A  P T       + PP+ SS PI     + P  L    +    P    A 
Sbjct: 441 LVVTNPCTIAAAPTTTFEVATCVSPPM-SSGPISNIEPTSPAALVMAPVAPKEPSTQVAT 499

Query: 224 PPPPPPPPPTPPPLP----PASVL----SDKAVKPQLAPLHLPPIPPPLPLL----PPCG 271
               P  PP P P      P+SVL    + K ++   A L   P  P    L     P  
Sbjct: 500 TLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTV 559

Query: 272 YPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPP 324
            P ++A P +         +P  PL P A+ + + SL  P   G  +SS T P
Sbjct: 560 LPLVQAAPKNSPSFQSTSSSPEIPLSPEATLA-KKSLGEPLPIGKPASSMTSP 611



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 31/117 (26%), Positives = 42/117 (35%), Gaps = 11/117 (9%)

Query: 263 PLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSET 322
           P P       P   A   + A     P  PPP  P    C   A+  A P P  ++ + T
Sbjct: 17  PQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIAST 76

Query: 323 PPPLP-PKSPSFQAPPQKAGAQA------LPAPPAPPG----SQPFLQKKRHGRPGA 368
           P  +P P+S S  A P     +A      L  PP  P     + P +     G P +
Sbjct: 77  PLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSS 133



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 81/331 (24%), Positives = 108/331 (32%), Gaps = 81/331 (24%)

Query: 141 SGPL--IPPASPRLGNTSEAHGAARTAPPRPNVPAPP----PPTPPPPPPPLPPPLPSSS 194
           SGP+  I P SP       A   A  AP  P+         P +PP P P     LPSS 
Sbjct: 469 SGPISNIEPTSPA------ALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSV 522

Query: 195 PIKTPLV------------SPPGP----LTKGNLPVVAPPVPCAPPPPPPPPPPTPP--- 235
            +K P              +P  P    LT    P V P V  AP   P     +     
Sbjct: 523 LVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEI 582

Query: 236 PLPPASVLSDKAVKPQLAPLHLPPIPPPLPL---------------LPPCGYPGLKAEPA 280
           PL P + L+ K++   L P+  P      PL                P    P LK+   
Sbjct: 583 PLSPEATLAKKSLGEPL-PIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLI 641

Query: 281 SPAQDA--QEPPAPPPPLPPYASCSPRASLPAPP----------------------LPGV 316
           +P   A   E   P    P  A  +   +  A P                      LP V
Sbjct: 642 TPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLV 701

Query: 317 NSSSETPPPLPPKSPSFQAPPQKAGA------QALPAPPAPPGSQPFLQKKRHGRPGAGG 370
            ++SE  P  P  SP     P           +++P+P  PP   P   KK  G      
Sbjct: 702 PTASENCPVAP--SPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSA 759

Query: 371 GKLNPPPAPPARSPTTELSSKSQQATAWTPT 401
             L P  + P   PT +  + +  ++  T T
Sbjct: 760 --LAPVASSPKECPTEDSGASATASSKGTLT 788


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score =  118 bits (296), Expect = 1e-26
 Identities = 118/406 (29%), Positives = 138/406 (33%), Gaps = 97/406 (23%)

Query: 2   PVPPPPPPPLPPPPPPLGA------PPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQ 55
           P  PPPPP  P  PPP G       PPP  P  PP   D S   R+ P            
Sbjct: 68  PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPP------------ 115

Query: 56  GTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQR 115
                          PQ    +G N+  G          PP  G          +P G  
Sbjct: 116 -------------GKPQGPPPQGGNQPQG---------PPPPPG----------KPQGPP 143

Query: 116 DVAGGKTGQGPGS----RAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNV 171
              G K  QGP      + P P+  NK+ S    PP  P+ G   +     +  PP P  
Sbjct: 144 PQGGNKP-QGPPPPGKPQGPPPQGDNKSRSSRS-PPGKPQ-GPPPQGGNQPQGPPPPPGK 200

Query: 172 PAPPPPT-------PPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPP 224
           P  PPP        PPPP  P  PP P          SPPG       P   PP     P
Sbjct: 201 PQGPPPQGGNKPQGPPPPGKPQGPP-PQGDNKSQSARSPPGK------PQGPPPQGGNQP 253

Query: 225 PPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQ 284
             PPPPP  P   PP         KPQ  P      PP  P  PP        +  S ++
Sbjct: 254 QGPPPPPGKPQGPPPQG-----GNKPQGPP------PPGKPQGPP-------PQGGSKSR 295

Query: 285 DAQEPPAPPPPLPPYASCSPRASLP------APPLPGVNSSSETPPPLPPKSPSFQAPPQ 338
            ++ PP  P   PP     P+   P       PP  G N     PPP  P+ P  Q   +
Sbjct: 296 SSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSK 355

Query: 339 KAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP 384
              A++ P  P  P  Q        G P   GG    P APPA  P
Sbjct: 356 SRSARSPPGKPQGPPQQE--GNNPQGPPPPAGGNPQQPQAPPAGQP 399



 Score =  114 bits (286), Expect = 2e-25
 Identities = 112/361 (31%), Positives = 130/361 (36%), Gaps = 53/361 (14%)

Query: 71  PQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVL--RPAGQRDVAGGKT-GQGPG 127
           PQ    +G NK  G  +       PP  G     G P    +P G     G K  G  P 
Sbjct: 36  PQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPP 95

Query: 128 SRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPT-------PP 180
            +   P         P  PP  P+ G   +     +  PP P  P  PPP        PP
Sbjct: 96  GKPQGPPPQGDKSRSPRSPPGKPQ-GPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPP 154

Query: 181 PPPPPLPPPLPSSSPIKTPLVSPPG-----PLTKGNLPVVAPPVPCAPPPPPP------- 228
           PP  P  PP P          SPPG     P   GN P   PP P  P  PPP       
Sbjct: 155 PPGKPQGPP-PQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQ 213

Query: 229 -PPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPA-QDA 286
            PPPP  P  PP     D   +   +P   P  PPP     P G P    +P  P  Q  
Sbjct: 214 GPPPPGKPQGPPPQ--GDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGG 271

Query: 287 QEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALP 346
            +P  PPPP  P            PP  G  S S   PP  P     Q PP + G Q  P
Sbjct: 272 NKPQGPPPPGKPQGP---------PPQGGSKSRSSRSPPGKP-----QGPPPQGGNQ--P 315

Query: 347 APPAPPGSQPFLQKKRHGRPGAGGGK-LNPPPAPPARSPTTELSSKSQQATAWTPTQQPG 405
             P PP  +P       G P  GG K   PPP    + P  +  SKS+ A   +P  +P 
Sbjct: 316 QGPPPPPGKP------QGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSAR--SPPGKPQ 367

Query: 406 G 406
           G
Sbjct: 368 G 368



 Score =  110 bits (274), Expect = 4e-24
 Identities = 100/319 (31%), Positives = 118/319 (36%), Gaps = 64/319 (20%)

Query: 117 VAGGKTGQGP-GSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPP 175
           +AG   G  P G   P          GP  PP  P+ G   +     +  PP P  P  P
Sbjct: 32  IAGNPQGAPPQGGNKPQ---------GPPSPPGKPQ-GPPPQGGNQPQGPPPPPGKPQGP 81

Query: 176 PPT-------PPPPPPPLPPPLPSSSPIKTPLVSPPG-----PLTKGNLPVVAPPVPCAP 223
           PP        PPPP  P  PP P     ++P  SPPG     P   GN P   PP P  P
Sbjct: 82  PPQGGNKPQGPPPPGKPQGPP-PQGDKSRSPR-SPPGKPQGPPPQGGNQPQGPPPPPGKP 139

Query: 224 PPPPP--------PPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGL 275
             PPP        PPPP  P  PP     D   +   +P   P  PPP     P G P  
Sbjct: 140 QGPPPQGGNKPQGPPPPGKPQGPPPQ--GDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPP 197

Query: 276 KAEPASPA-QDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQ 334
             +P  P  Q   +P  PPPP  P          P P     + S+ +PP  P      Q
Sbjct: 198 PGKPQGPPPQGGNKPQGPPPPGKPQG--------PPPQGDNKSQSARSPPGKP------Q 243

Query: 335 APPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPP------APPARSPTTEL 388
            PP + G Q  P  P PP  +P       G P  GG K   PP       PP +  +   
Sbjct: 244 GPPPQGGNQ--PQGPPPPPGKP------QGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSR 295

Query: 389 SSKSQQATAWTPTQQPGGQ 407
           SS+S       P  Q G Q
Sbjct: 296 SSRSPPGKPQGPPPQGGNQ 314



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 91/320 (28%), Positives = 103/320 (32%), Gaps = 56/320 (17%)

Query: 2   PVPPPPPPPLPPPPPPLGA------PPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQ 55
           P  PPPPP  P  PPP G       PPP  P  PP   D  S     P G+         
Sbjct: 129 PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGK--------- 179

Query: 56  GTRLRKVTQINDRSAPQIESSKGTNK-EGGGSANTRGASTPPTLGDLFAGGFPVLRPAG- 113
                          PQ    +G N+ +G      +    PP  G+   G  P  +P G 
Sbjct: 180 ---------------PQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP 224

Query: 114 --QRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNV 171
             Q D         PG     P        GP  PP  P+ G   +     +  PP    
Sbjct: 225 PPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQ-GPPPQGGNKPQGPPPPGKP 283

Query: 172 PAPPP--------PTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAP 223
             PPP           PP  P  PPP   + P   P   PPG       P   PP     
Sbjct: 284 QGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPP--PPPGK------PQGPPPQGGNK 335

Query: 224 PPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEP-ASP 282
           P  PPPP     P P     S  A  P   P   P      P  PP    G   +P A P
Sbjct: 336 PQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPP 395

Query: 283 AQDAQEPPAPP----PPLPP 298
           A   Q PP PP    P  PP
Sbjct: 396 AGQPQGPPRPPQGGRPSRPP 415



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 37/106 (34%), Positives = 42/106 (39%), Gaps = 17/106 (16%)

Query: 310 APPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAG 369
           APP  G   +    PP PP  P  Q PP + G Q    PP PPG       K  G P  G
Sbjct: 39  APPQGG---NKPQGPPSPPGKP--QGPPPQGGNQP-QGPPPPPG-------KPQGPPPQG 85

Query: 370 GGKLN--PPPAPPARSPTTELSSKSQQATAWTPTQQP--GGQLRNG 411
           G K    PPP  P   P     S+S ++    P   P  GG    G
Sbjct: 86  GNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQG 131


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
           sapiens]
          Length = 2715

 Score =  114 bits (286), Expect = 2e-25
 Identities = 123/456 (26%), Positives = 169/456 (37%), Gaps = 64/456 (14%)

Query: 2   PVPPPPPPPLPPP----PPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGT 57
           P  P PPPPLPPP    PPPL  PPPPP S PP+ +         P    A     +   
Sbjct: 408 PPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPS---------PPPPPAQEEQEESPP 458

Query: 58  RLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGG----FPVLRPAG 113
            +   T    R  P +  S+   +E    A   G S P        GG     P + P  
Sbjct: 459 PVVPATCSRKRGRPPLTPSQRAERE-AARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKS 517

Query: 114 QRDVAGGKTGQGPGSRAPSPRL---PNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPN 170
              +   +    P   A S R+   P + +     PP  P++  +        T+PP P 
Sbjct: 518 TTFLKNIRQFIMPVVSARSSRVIKTPRRFMDED--PPKPPKVEVSPVLRPPITTSPPVPQ 575

Query: 171 VPAP---PPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPP 227
            PAP   PP  P PP  P+P P    S ++ P               +   +P  PP PP
Sbjct: 576 EPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTF---------RWTSLTRELPPPPPAPP 626

Query: 228 PPPPPTPPPLPPASVLSDKAVK-PQLAP--LHLPPIPPPLPLLPPCGYPGLKAEPASPAQ 284
           PPP P+PPP P  S      ++ PQ  P   HL  I   +   PP G P        PA 
Sbjct: 627 PPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHL-KIYESVLTPPPLGAPEAPEPEPPPAD 685

Query: 285 DAQEPPAPP----------PPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQ 334
           D+   P P           P   P  +   +A +     P +++  +T   L       Q
Sbjct: 686 DSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQL---LQPLQ 742

Query: 335 APPQKAGAQALP------APPAPPGSQPFLQKKR----HGRPGAGGGKLNPPPAPPARSP 384
           A   +   QALP       PP  P   P L+K R       P +G  +        A+  
Sbjct: 743 ALQTQLLPQALPPPQPQLQPPPSPQQMPPLEKARIAGVGSLPLSGVEEKMFSLLKRAKVQ 802

Query: 385 TTELSSKSQQATAWTPTQQPGGQLRN--GSLHIIDD 418
             ++  + QQ  A +    PGGQ+    G++  I D
Sbjct: 803 LFKIDQQQQQKVAASMPLSPGGQMEEVAGAVKQISD 838



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 105/371 (28%), Positives = 126/371 (33%), Gaps = 87/371 (23%)

Query: 70   APQIES----SKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQR-----DVAGG 120
            AP+IE       GT+ E       RG  TPP+   +   G  VL  AG R     D+   
Sbjct: 2055 APRIEQLDGVDDGTDSEAEAVQQPRGQGTPPSGPGVVRAG--VLGAAGDRARPPEDLPSE 2112

Query: 121  ------KTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAART---APPRPNV 171
                  K   GPG     PR  +   + PL   + P  G T+      RT    P  P V
Sbjct: 2113 IVDFVLKNLGGPGDGGAGPREESLPPAPPLANGSQPSQGLTASPADPTRTFAWLPGAPGV 2172

Query: 172  ------PAPPPPTPP------------------------PPP---PPLPPPLPSSSPIKT 198
                  PAP PP P                         PPP   PPLPP +  ++P   
Sbjct: 2173 RVLSLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPLPPTISPTAPTSW 2232

Query: 199  PLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPP--PPTPPPLPPASVLSDKAVKPQLAPLH 256
             L  PPGPL  G LPVV    P  PPPPPP      + P  PP   +  K V        
Sbjct: 2233 TL--PPGPLL-GVLPVVGVVRPAPPPPPPPLTLVLSSGPASPPRQAIRVKRVSTFSG--R 2287

Query: 257  LPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAP----- 311
             PP PPP            KA       +A E     P L        R   P       
Sbjct: 2288 SPPAPPP-----------YKAPRLDEDGEASEDTPQVPGLGSGGFSRVRMKTPTVRGVLD 2336

Query: 312  -PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQP--FLQKKRHGRPGA 368
               PG  +  E+P PL  +SP    P           PP  P   P   L+ + H   G 
Sbjct: 2337 LDRPGEPAGEESPGPLQERSPLLPLPED--------GPPQVPDGPPDLLLESQWHHYSGE 2388

Query: 369  GGGKLNPPPAP 379
                   PP+P
Sbjct: 2389 ASSSEEEPPSP 2399



 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 84/295 (28%), Positives = 107/295 (36%), Gaps = 88/295 (29%)

Query: 165 APPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPP 224
           A  +     PPPP  PP P P PPPLP       P  SPP PL         PP P +PP
Sbjct: 393 AAEKEEAKLPPPPLTPPAPSP-PPPLP------PPSTSPPPPLCP------PPPPPVSPP 439

Query: 225 PPPPPPPP--------TPPPLPPASVLSDKAVKPQLAPLH--------------LPPIPP 262
           P P PPPP        +PPP+ PA+  S K  +P L P                 PP P 
Sbjct: 440 PLPSPPPPPAQEEQEESPPPVVPAT-CSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPT 498

Query: 263 P----------LPLLPPCGYPGLK-----AEPASPAQDA-----------QEPPAPP--- 293
           P           P + P     LK       P   A+ +           ++PP PP   
Sbjct: 499 PSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVE 558

Query: 294 --PPLPPYASCS---PRASLPAPPLPGVNSSSETPPPLPPKSPS-FQAPPQKAGAQALPA 347
             P L P  + S   P+   P P  P   +   TP PLP K  S  + P  +  +     
Sbjct: 559 VSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTREL 618

Query: 348 PPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQ 402
           PP PP   P                  P P+PP    T+       +A  +TP++
Sbjct: 619 PPPPPAPPP-----------------PPAPSPPPAPATSSRRPLLLRAPQFTPSE 656



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 117/454 (25%), Positives = 151/454 (33%), Gaps = 98/454 (21%)

Query: 5   PPPPPPLPPPPPPLGA-----PPPPPPSAPPVSTDTSSLRRADP-KGRSALLADIQQGTR 58
           P PPPP+ P     G+      P P P  P     +S   R    +GR   L  + +   
Sbjct: 250 PEPPPPVVPVKHQTGSWKCKEGPGPGPGTPRRGGQSSRGGRGGRGRGRGGGLPFVIKFVS 309

Query: 59  LRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQR-DV 117
             K  ++   S   +ES +G      G         P        GG P  +   Q+ D 
Sbjct: 310 RAKKVKMGQLSLG-LESGQGQ-----GQHEESWQDVPQRRVGSGQGGSPCWKKQEQKLDD 363

Query: 118 AGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPP-RPNVPAPPP 176
              +  +             + ++  ++P A        E   A    PP  P  P+PPP
Sbjct: 364 EEEEKKEEEEKDKEGEEKEERAVAEEMMPAA--------EKEEAKLPPPPLTPPAPSPPP 415

Query: 177 PTPPP---PPPPL-PPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPV------------P 220
           P PPP   PPPPL PPP P  SP   PL SPP P  +       PPV            P
Sbjct: 416 PLPPPSTSPPPPLCPPPPPPVSP--PPLPSPPPPPAQEEQEESPPPVVPATCSRKRGRPP 473

Query: 221 CAP------------PPPPPPPPPTP------PP---------------------LPPAS 241
             P            P    PP PTP      PP                     +P  S
Sbjct: 474 LTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVS 533

Query: 242 VLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYAS 301
             S + +K     +   P  PP   + P   P +   P  P + A  P  P  P PP   
Sbjct: 534 ARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTP 593

Query: 302 C----SPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPF 357
                  R+ L  P     + + E PPP P   P    PP    A + P  PA    +P 
Sbjct: 594 VPLPEKRRSILREPTFRWTSLTRELPPPPPAPPP----PP----APSPPPAPATSSRRPL 645

Query: 358 LQKKRHGRPGAGGGK-----LNPPP--APPARSP 384
           L +     P     K     L PPP  AP A  P
Sbjct: 646 LLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEP 679



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 42/128 (32%), Positives = 54/128 (42%), Gaps = 15/128 (11%)

Query: 277 AEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAP 336
           AE   PA + +E   PPPPL      +P A  P PPLP   S+S  PP  PP  P    P
Sbjct: 387 AEEMMPAAEKEEAKLPPPPL------TPPAPSPPPPLP-PPSTSPPPPLCPPPPPPVSPP 439

Query: 337 PQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQAT 396
           P       LP+PP PP  +   +      P     K   PP  P++    E +    + T
Sbjct: 440 P-------LPSPPPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGT 492

Query: 397 AWTPTQQP 404
           +  PT  P
Sbjct: 493 S-PPTPTP 499



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 109/446 (24%), Positives = 140/446 (31%), Gaps = 77/446 (17%)

Query: 6    PPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQI 65
            P PP     P PL   PPP   A P    +  LR   P      L               
Sbjct: 1907 PAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTS----------- 1955

Query: 66   NDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDL-FAGGFPVLRPAGQRDVAGGKTGQ 124
             + + P    S    ++ G         +  +  DL FA       P  +  VA G  G 
Sbjct: 1956 GELAPPGPAPSPPPPEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGS 2015

Query: 125  ---GPGSRA-----PSPR---LPNKTISGP-LIPPASP------RLGNTSEAHGAARTAP 166
               GPG  +     P+ R    P   +S P L P A+P      +L    +   +   A 
Sbjct: 2016 SHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLAPSATPGAPRIEQLDGVDDGTDSEAEAV 2075

Query: 167  PRPNVPAPPPPTP--------------PPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNL 212
             +P     PP  P                PP  LP     S  +   L +  GP   G  
Sbjct: 2076 QQPRGQGTPPSGPGVVRAGVLGAAGDRARPPEDLP-----SEIVDFVLKNLGGPGDGG-- 2128

Query: 213  PVVAPPVPCAPPPPP------PPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIP-PPLP 265
                P     PP PP      P    T  P  P    +     P +  L L P P PP P
Sbjct: 2129 --AGPREESLPPAPPLANGSQPSQGLTASPADPTRTFAWLPGAPGVRVLSLGPAPEPPKP 2186

Query: 266  LLPPCGYPGLKAEPASPAQDAQEPPAPP---PPLPPYASCSPRAS--LPAPPLPGVNSSS 320
                        +         EP  PP   PPLPP  S +   S  LP  PL GV    
Sbjct: 2187 ATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPLPPTISPTAPTSWTLPPGPLLGVLPVV 2246

Query: 321  ETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPP 380
                P PP       PP       L + PA P  Q    K+     G      +PP  PP
Sbjct: 2247 GVVRPAPP-------PPPPPLTLVLSSGPASPPRQAIRVKRVSTFSGR-----SPPAPPP 2294

Query: 381  ARSPTTELSSKSQQATAWTPTQQPGG 406
             ++P  +   ++ + T   P    GG
Sbjct: 2295 YKAPRLDEDGEASEDTPQVPGLGSGG 2320



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 92/368 (25%), Positives = 129/368 (35%), Gaps = 64/368 (17%)

Query: 86   SANTRGASTPPTLGDLFAGGFPV-----------LRP-AGQRDVAGGKTGQGPGSRAPS- 132
            S+   G   PP   D+   G P            LRP +G       ++  G   + P+ 
Sbjct: 1811 SSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSGSAPPPAPRSFSGARIKVPNY 1870

Query: 133  --PRLPNKTIS-GPLIPPASPRLGNTSEAHGAART------APPRPNV-PAPPPPTPPPP 182
               R P   +S GPL  P SP    +S  H           APPR +  P+P  P  PPP
Sbjct: 1871 SPSRRPLGGVSFGPLPSPGSP----SSLTHHIPTVGDPDFPAPPRRSRRPSPLAPR-PPP 1925

Query: 183  PPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASV 242
                 PPL +S  ++ P   PP  +     P      P  P P PPPP    P      V
Sbjct: 1926 SRWASPPLKTSPQLRVP---PPTSVVTALTPTSGELAPPGPAPSPPPPEDLGPDFEDMEV 1982

Query: 243  LSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAP-------PPP 295
            +S  +         L    P    +   G  G  +    P   ++E  +P       P  
Sbjct: 1983 VSGLSAADLDFAASLLGTEPFQEEIVAAGAMG--SSHGGPGDSSEEESSPTSRYIHFPVT 2040

Query: 296  LPPYASCSPRASLPAP---PLPGVNSSSETPPPLPPKSPSFQAPPQ-----------KAG 341
            +      +P A+  AP    L GV+  +++      +      PP             AG
Sbjct: 2041 VVSAPGLAPSATPGAPRIEQLDGVDDGTDSEAEAVQQPRGQGTPPSGPGVVRAGVLGAAG 2100

Query: 342  AQALPAPPAPPGSQPFLQKKRHGRPGAGGG---KLNPPPAPP---ARSPTTELSSKSQQA 395
             +A P    P     F+ K   G PG GG    + + PPAPP      P+  L++     
Sbjct: 2101 DRARPPEDLPSEIVDFVLKNL-GGPGDGGAGPREESLPPAPPLANGSQPSQGLTASPADP 2159

Query: 396  T---AWTP 400
            T   AW P
Sbjct: 2160 TRTFAWLP 2167



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 66/274 (24%), Positives = 93/274 (33%), Gaps = 52/274 (18%)

Query: 182  PPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPAS 241
            P P   PP     P+ T ++ P  P           P+    PP  P     PPP  P S
Sbjct: 1808 PAPSSEPPGGEDPPLDTDVLVPGAPERHS-------PIQNLDPPLRPDSGSAPPP-APRS 1859

Query: 242  VLSDKAVKPQLAPLHLP-------PIPPP------LPLLPPCGYPGLKAEPASPAQDAQE 288
                +   P  +P   P       P+P P         +P  G P   A P    + +  
Sbjct: 1860 FSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAPPRRSRRPSPL 1919

Query: 289  PPAPPPP--LPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQK------- 339
             P PPP     P    SP+  +P PP   V + + T   L P  P+   PP +       
Sbjct: 1920 APRPPPSRWASPPLKTSPQLRVP-PPTSVVTALTPTSGELAPPGPAPSPPPPEDLGPDFE 1978

Query: 340  -------AGAQALPAPPAPPGSQPFLQK--------KRHGRPGAGGGKLNPPPAPPARSP 384
                     A  L    +  G++PF ++          HG PG    + + P +     P
Sbjct: 1979 DMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFP 2038

Query: 385  TTELSSKSQQATAWTPTQQPGGQLRNGSLHIIDD 418
             T +S     A    P+  PG   R   L  +DD
Sbjct: 2039 VTVVS-----APGLAPSATPGAP-RIEQLDGVDD 2066



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 60/218 (27%), Positives = 77/218 (35%), Gaps = 42/218 (19%)

Query: 2    PVPPP----PPPP-----------LPPPP-----PPLGAPPPPPPSAPPVSTDTSSLRRA 41
            PVPPP    P PP           LPP P     P +G   P PP  PP  T   S   A
Sbjct: 2210 PVPPPVKQPPLPPTISPTAPTSWTLPPGPLLGVLPVVGVVRPAPPPPPPPLTLVLSSGPA 2269

Query: 42   DPKGRSALLADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDL 101
             P          +Q  R+++V+  + RS P     K    +  G A    +   P +  L
Sbjct: 2270 SPP---------RQAIRVKRVSTFSGRSPPAPPPYKAPRLDEDGEA----SEDTPQVPGL 2316

Query: 102  FAGGF-------PVLRPAGQRDVAGGKTG-QGPGS-RAPSPRLPNKTISGPLIPPASPRL 152
             +GGF       P +R     D  G   G + PG  +  SP LP      P +P   P L
Sbjct: 2317 GSGGFSRVRMKTPTVRGVLDLDRPGEPAGEESPGPLQERSPLLPLPEDGPPQVPDGPPDL 2376

Query: 153  GNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPL 190
               S+ H  +  A      P  P       P    P L
Sbjct: 2377 LLESQWHHYSGEASSSEEEPPSPDDKENQAPKRTGPHL 2414



 Score = 33.9 bits (76), Expect = 0.34
 Identities = 39/150 (26%), Positives = 50/150 (33%), Gaps = 26/150 (17%)

Query: 73  IESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAG------------- 119
           + S +G    G G  +      PP L D+     P   PA +R   G             
Sbjct: 141 LRSQRGRAPRGRGRKHKTTPLPPPRLADV--APTPPKTPARKRGEEGTERMVQALTELLR 198

Query: 120 -GKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPT 178
             +  Q P SRA  P  P ++   P   PA P      +A   A  A   P         
Sbjct: 199 RAQAPQAPRSRACEPSTPRRSRGRPPGRPAGP-CRRKQQAVVVAEAAVTIPK-------- 249

Query: 179 PPPPPPPLPPPLPSSSPIKTPLVSPPGPLT 208
            P PPPP+ P    +   K      PGP T
Sbjct: 250 -PEPPPPVVPVKHQTGSWKCKEGPGPGPGT 278



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 51/210 (24%), Positives = 75/210 (35%), Gaps = 26/210 (12%)

Query: 41  ADPKGRSALLADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGD 100
           A+P   +ALL  +     LR++ ++   + P+++  +G  + G G   +RG        D
Sbjct: 59  AEPGEDTALLRLLGLRRGLRRLRRL--WAGPRVQRGRGRGR-GRGWGPSRGCVPEEESSD 115

Query: 101 LFAG-----GFPV---LRPAGQRDVAGGKTGQGPGSRA--------PSPRLPNKTISGPL 144
             +      GF     + P+  R     + G+ P  R         P PRL +   + P 
Sbjct: 116 GESDEEEFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTTPLPPPRLADVAPTPPK 175

Query: 145 IPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPP 204
            P A  R    +E    A T   R    AP  P      P  P       P +     P 
Sbjct: 176 TP-ARKRGEEGTERMVQALTELLR-RAQAPQAPRSRACEPSTPRRSRGRPPGR-----PA 228

Query: 205 GPLTKGNLPVVAPPVPCAPPPPPPPPPPTP 234
           GP  +    VV        P P PPPP  P
Sbjct: 229 GPCRRKQQAVVVAEAAVTIPKPEPPPPVVP 258



 Score = 30.4 bits (67), Expect = 3.7
 Identities = 40/155 (25%), Positives = 51/155 (32%), Gaps = 24/155 (15%)

Query: 223 PPPPPPPPPPTPPPLPPASVLSD--KAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPA 280
           PPP      PTPP  P      +  + +   L  L      P  P    C       EP+
Sbjct: 162 PPPRLADVAPTPPKTPARKRGEEGTERMVQALTELLRRAQAPQAPRSRAC-------EPS 214

Query: 281 SPAQDAQEP---PAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPP 337
           +P +    P   PA P      A     A++  P         E PPP+ P      +  
Sbjct: 215 TPRRSRGRPPGRPAGPCRRKQQAVVVAEAAVTIP-------KPEPPPPVVPVKHQTGSWK 267

Query: 338 QKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGK 372
            K G    P  P   G     Q  R GR G G G+
Sbjct: 268 CKEGPGPGPGTPRRGG-----QSSRGGRGGRGRGR 297


>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
          Length = 1263

 Score =  112 bits (281), Expect = 6e-25
 Identities = 74/205 (36%), Positives = 86/205 (41%), Gaps = 35/205 (17%)

Query: 186 LPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPC----APPPPPPPPPPTPPPLPPAS 241
           +PP +PS +P+      PP P   G+   + PP P       PPPPPPPPP PPPLP   
Sbjct: 563 VPPSVPSRAPV------PPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGV 616

Query: 242 VLSDKAVKPQLAPLHLPP-------IPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPP 294
            +S     P    +  PP       IPPP PL    G P   + P   A        PPP
Sbjct: 617 CISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIP------PPP 670

Query: 295 PLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGS 354
           PLP  A   P    P PPLPG       PPPLP ++     PP   G   +P PP  PG 
Sbjct: 671 PLPGSARIPP----PPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGG 726

Query: 355 QPFLQKKRHGRPGAGGGKLNPPPAP 379
                    G P    G   PPP P
Sbjct: 727 P--------GIPPPPPGMGMPPPPP 743



 Score =  106 bits (265), Expect = 4e-23
 Identities = 72/200 (36%), Positives = 77/200 (38%), Gaps = 34/200 (17%)

Query: 171 VPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPP 230
           +  PP      P PP  PPLP  S    P    PG  T               PPPPPPP
Sbjct: 561 ITVPPSVPSRAPVPP-APPLPGDSGTIIPPPPAPGDST--------------TPPPPPPP 605

Query: 231 PPTPPPLPPASVLSDKAVKPQLAPLHLPP-------IPPPLPLLPPCGYP-------GLK 276
           PP PPPLP    +S     P    +  PP       IPPP PL    G P       G  
Sbjct: 606 PPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTA 665

Query: 277 AEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAP 336
             P  P   +   P PPPPLP  A   P    P PPLPG       PPPL P  P    P
Sbjct: 666 IPPPPPLPGSARIPPPPPPLPGSAGIPP----PPPPLPGEAGMPPPPPPL-PGGPGIPPP 720

Query: 337 PQKAGAQALPAPPAPPGSQP 356
           P   G   +P PP   G  P
Sbjct: 721 PPFPGGPGIPPPPPGMGMPP 740



 Score =  106 bits (265), Expect = 4e-23
 Identities = 80/224 (35%), Positives = 91/224 (40%), Gaps = 49/224 (21%)

Query: 135 LPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSS 194
           +P    S   +PPA P  G++    G     PP P     PPP  PPPPPP PPPLP   
Sbjct: 563 VPPSVPSRAPVPPAPPLPGDS----GTIIPPPPAPGDSTTPPP--PPPPPPPPPPLPGGV 616

Query: 195 PIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPP--PLPPASVLSDKAVKPQL 252
            I +P   P G         ++PP P +     PPPPP P    +P  S L      P  
Sbjct: 617 CISSPPSLPGG-------TAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPP 669

Query: 253 APL----HLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASL 308
            PL     +PP PPPLP     G  G+              P PPPPLP  A   P    
Sbjct: 670 PPLPGSARIPPPPPPLP-----GSAGI--------------PPPPPPLPGEAGMPP---- 706

Query: 309 PAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPP 352
           P PPLPG       PPP  P  P    PP   G      PP PP
Sbjct: 707 PPPPLPG--GPGIPPPPPFPGGPGIPPPPPGMG-----MPPPPP 743



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 64/195 (32%), Positives = 71/195 (36%), Gaps = 31/195 (15%)

Query: 211 NLPVVAPPVPCAPPPPPPPPPPTPPP------LPPASVLSDKAVKPQLAPLHLPPIPPPL 264
           +L   A  VP + P   P PP  P P      +PP     D    P   P   PP PPPL
Sbjct: 555 SLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPP--PPPPPPPL 612

Query: 265 P----LLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPA-------PPL 313
           P    +  P   PG  A    P         PPPPLP        +SLP        PPL
Sbjct: 613 PGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPL 672

Query: 314 PGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAP----PGSQPFLQKKRHGRPGAG 369
           PG       PPPLP  +     PP   G   +P PP P    PG  P         P   
Sbjct: 673 PGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPP--------PPPFP 724

Query: 370 GGKLNPPPAPPARSP 384
           GG   PPP P    P
Sbjct: 725 GGPGIPPPPPGMGMP 739



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 84/266 (31%), Positives = 96/266 (36%), Gaps = 107/266 (40%)

Query: 2   PVPPPPPPP------LPPPP-------PPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSA 48
           PVPP PP P      +PPPP       PP   PPPPPP  PP+           P G   
Sbjct: 572 PVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPP--PPL-----------PGG--- 615

Query: 49  LLADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPV 108
                           +   S P +          GG+A    +  PP  GD      P 
Sbjct: 616 ----------------VCISSPPSLP---------GGTAI---SPPPPLSGDATIPPPPP 647

Query: 109 LRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPR 168
           L              +G G  +PS  LP     G  IPP  P         G+AR  PP 
Sbjct: 648 L-------------PEGVGIPSPS-SLP----GGTAIPPPPP-------LPGSARIPPPP 682

Query: 169 PNVPAPPPPTPPPPP-------PPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPC 221
           P +P      PPPPP       PP PPPLP       P + PP P   G         P 
Sbjct: 683 PPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGG-----PGIPPPPPFPGG---------PG 728

Query: 222 APPPPP----PPPPPTPPPLPPASVL 243
            PPPPP    PPPPP    +P A VL
Sbjct: 729 IPPPPPGMGMPPPPPFGFGVPAAPVL 754



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 64/187 (34%), Positives = 74/187 (39%), Gaps = 37/187 (19%)

Query: 95  PPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGP----GSRAPSPRLP---NKTISGPLIPP 147
           PP  GD      P   P     + GG     P    G  A SP  P   + TI  P  PP
Sbjct: 590 PPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPP--PP 647

Query: 148 ASPRLGNTSEAHGAARTAPPRPNVPAPPPPTP-----PPPPPPLP-----PPLPSSSPIK 197
               +G  S +     TA P      PPPP P     PPPPPPLP     PP P   P +
Sbjct: 648 LPEGVGIPSPSSLPGGTAIP------PPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGE 701

Query: 198 TPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPP----PPTPP--------PLPPASVLSD 245
             +  PP PL  G      PP P  P  PPPPP    PP PP        P+ P  +   
Sbjct: 702 AGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPK 761

Query: 246 KAVKPQL 252
           K  KP++
Sbjct: 762 KLYKPEV 768



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/114 (29%), Positives = 42/114 (36%), Gaps = 26/114 (22%)

Query: 293 PPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPP 352
           PP +P  A   P     APPLPG + +   PPP P             G    P PP PP
Sbjct: 564 PPSVPSRAPVPP-----APPLPGDSGTIIPPPPAP-------------GDSTTPPPPPPP 605

Query: 353 GSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQPGG 406
              P         P  GG  ++ PP+ P  +  +     S  AT   P   P G
Sbjct: 606 PPPP--------PPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEG 651



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 14/27 (51%), Positives = 15/27 (55%)

Query: 3   VPPPPPPPLPPPPPPLGAPPPPPPSAP 29
           +PPPPP    PPPPP G   P  P  P
Sbjct: 729 IPPPPPGMGMPPPPPFGFGVPAAPVLP 755


>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
          Length = 1272

 Score =  112 bits (281), Expect = 6e-25
 Identities = 74/205 (36%), Positives = 86/205 (41%), Gaps = 35/205 (17%)

Query: 186 LPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPC----APPPPPPPPPPTPPPLPPAS 241
           +PP +PS +P+      PP P   G+   + PP P       PPPPPPPPP PPPLP   
Sbjct: 572 VPPSVPSRAPV------PPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGV 625

Query: 242 VLSDKAVKPQLAPLHLPP-------IPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPP 294
            +S     P    +  PP       IPPP PL    G P   + P   A        PPP
Sbjct: 626 CISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIP------PPP 679

Query: 295 PLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGS 354
           PLP  A   P    P PPLPG       PPPLP ++     PP   G   +P PP  PG 
Sbjct: 680 PLPGSARIPP----PPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGG 735

Query: 355 QPFLQKKRHGRPGAGGGKLNPPPAP 379
                    G P    G   PPP P
Sbjct: 736 P--------GIPPPPPGMGMPPPPP 752



 Score =  106 bits (265), Expect = 4e-23
 Identities = 72/200 (36%), Positives = 77/200 (38%), Gaps = 34/200 (17%)

Query: 171 VPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPP 230
           +  PP      P PP  PPLP  S    P    PG  T               PPPPPPP
Sbjct: 570 ITVPPSVPSRAPVPP-APPLPGDSGTIIPPPPAPGDST--------------TPPPPPPP 614

Query: 231 PPTPPPLPPASVLSDKAVKPQLAPLHLPP-------IPPPLPLLPPCGYP-------GLK 276
           PP PPPLP    +S     P    +  PP       IPPP PL    G P       G  
Sbjct: 615 PPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTA 674

Query: 277 AEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAP 336
             P  P   +   P PPPPLP  A   P    P PPLPG       PPPL P  P    P
Sbjct: 675 IPPPPPLPGSARIPPPPPPLPGSAGIPP----PPPPLPGEAGMPPPPPPL-PGGPGIPPP 729

Query: 337 PQKAGAQALPAPPAPPGSQP 356
           P   G   +P PP   G  P
Sbjct: 730 PPFPGGPGIPPPPPGMGMPP 749



 Score =  106 bits (265), Expect = 4e-23
 Identities = 80/224 (35%), Positives = 91/224 (40%), Gaps = 49/224 (21%)

Query: 135 LPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSS 194
           +P    S   +PPA P  G++    G     PP P     PPP  PPPPPP PPPLP   
Sbjct: 572 VPPSVPSRAPVPPAPPLPGDS----GTIIPPPPAPGDSTTPPP--PPPPPPPPPPLPGGV 625

Query: 195 PIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPP--PLPPASVLSDKAVKPQL 252
            I +P   P G         ++PP P +     PPPPP P    +P  S L      P  
Sbjct: 626 CISSPPSLPGG-------TAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPP 678

Query: 253 APL----HLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASL 308
            PL     +PP PPPLP     G  G+              P PPPPLP  A   P    
Sbjct: 679 PPLPGSARIPPPPPPLP-----GSAGI--------------PPPPPPLPGEAGMPP---- 715

Query: 309 PAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPP 352
           P PPLPG       PPP  P  P    PP   G      PP PP
Sbjct: 716 PPPPLPG--GPGIPPPPPFPGGPGIPPPPPGMG-----MPPPPP 752



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 64/195 (32%), Positives = 71/195 (36%), Gaps = 31/195 (15%)

Query: 211 NLPVVAPPVPCAPPPPPPPPPPTPPP------LPPASVLSDKAVKPQLAPLHLPPIPPPL 264
           +L   A  VP + P   P PP  P P      +PP     D    P   P   PP PPPL
Sbjct: 564 SLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPP--PPPPPPPL 621

Query: 265 P----LLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPA-------PPL 313
           P    +  P   PG  A    P         PPPPLP        +SLP        PPL
Sbjct: 622 PGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPL 681

Query: 314 PGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAP----PGSQPFLQKKRHGRPGAG 369
           PG       PPPLP  +     PP   G   +P PP P    PG  P         P   
Sbjct: 682 PGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPP--------PPPFP 733

Query: 370 GGKLNPPPAPPARSP 384
           GG   PPP P    P
Sbjct: 734 GGPGIPPPPPGMGMP 748



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 84/266 (31%), Positives = 96/266 (36%), Gaps = 107/266 (40%)

Query: 2   PVPPPPPPP------LPPPP-------PPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSA 48
           PVPP PP P      +PPPP       PP   PPPPPP  PP+           P G   
Sbjct: 581 PVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPP--PPL-----------PGG--- 624

Query: 49  LLADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPV 108
                           +   S P +          GG+A    +  PP  GD      P 
Sbjct: 625 ----------------VCISSPPSLP---------GGTAI---SPPPPLSGDATIPPPPP 656

Query: 109 LRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPR 168
           L              +G G  +PS  LP     G  IPP  P         G+AR  PP 
Sbjct: 657 L-------------PEGVGIPSPS-SLP----GGTAIPPPPP-------LPGSARIPPPP 691

Query: 169 PNVPAPPPPTPPPPP-------PPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPC 221
           P +P      PPPPP       PP PPPLP       P + PP P   G         P 
Sbjct: 692 PPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGG-----PGIPPPPPFPGG---------PG 737

Query: 222 APPPPP----PPPPPTPPPLPPASVL 243
            PPPPP    PPPPP    +P A VL
Sbjct: 738 IPPPPPGMGMPPPPPFGFGVPAAPVL 763



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 64/187 (34%), Positives = 74/187 (39%), Gaps = 37/187 (19%)

Query: 95  PPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGP----GSRAPSPRLP---NKTISGPLIPP 147
           PP  GD      P   P     + GG     P    G  A SP  P   + TI  P  PP
Sbjct: 599 PPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPP--PP 656

Query: 148 ASPRLGNTSEAHGAARTAPPRPNVPAPPPPTP-----PPPPPPLP-----PPLPSSSPIK 197
               +G  S +     TA P      PPPP P     PPPPPPLP     PP P   P +
Sbjct: 657 LPEGVGIPSPSSLPGGTAIP------PPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGE 710

Query: 198 TPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPP----PPTPP--------PLPPASVLSD 245
             +  PP PL  G      PP P  P  PPPPP    PP PP        P+ P  +   
Sbjct: 711 AGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPK 770

Query: 246 KAVKPQL 252
           K  KP++
Sbjct: 771 KLYKPEV 777



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/114 (29%), Positives = 42/114 (36%), Gaps = 26/114 (22%)

Query: 293 PPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPP 352
           PP +P  A   P     APPLPG + +   PPP P             G    P PP PP
Sbjct: 573 PPSVPSRAPVPP-----APPLPGDSGTIIPPPPAP-------------GDSTTPPPPPPP 614

Query: 353 GSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQPGG 406
              P         P  GG  ++ PP+ P  +  +     S  AT   P   P G
Sbjct: 615 PPPP--------PPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEG 660



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 14/27 (51%), Positives = 15/27 (55%)

Query: 3   VPPPPPPPLPPPPPPLGAPPPPPPSAP 29
           +PPPPP    PPPPP G   P  P  P
Sbjct: 738 IPPPPPGMGMPPPPPFGFGVPAAPVLP 764


>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
           preproprotein [Homo sapiens]
          Length = 331

 Score =  112 bits (281), Expect = 6e-25
 Identities = 103/305 (33%), Positives = 119/305 (39%), Gaps = 66/305 (21%)

Query: 128 SRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPT-------PP 180
           S+  SP L      GP     SP+ GN  +        PP P  P  PPP        PP
Sbjct: 24  SQEESPSLIAGNPQGP-----SPQGGNKPQG------PPPPPGKPQGPPPQGGNKPQGPP 72

Query: 181 PPPPPLPPPLPSSSPIKTPLVSPPG-----PLTKGNLPVVAPPVPCAPPPPPP------- 228
           PP  P  PP P     ++P  SPPG     P   GN P   PP P  P  PPP       
Sbjct: 73  PPGKPQGPP-PQGDKSRSPR-SPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNRPQ 130

Query: 229 -PPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPA-QDA 286
            PPPP  P  PP     DK+  P+ +P   P  PPP     P G P    +P  P  Q  
Sbjct: 131 GPPPPGKPQGPPPQ--GDKSRSPR-SPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGG 187

Query: 287 QEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALP 346
           ++P  PPPP  P            PP  G  S S   PP  P+ P    PPQ  G     
Sbjct: 188 KKPQGPPPPGKPQG----------PPPQGDKSRSSQSPPGKPQGP----PPQ--GGNQPQ 231

Query: 347 APPAPPGSQPFLQKKRHGRPGAGGGKLNPPP------APPARSPTTELSSKSQQATAWTP 400
            PP PPG       K  G P  GG K   PP       PPA+  +   S++S       P
Sbjct: 232 GPPPPPG-------KPQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARSPPGKPQGP 284

Query: 401 TQQPG 405
            QQ G
Sbjct: 285 PQQEG 289



 Score =  105 bits (262), Expect = 9e-23
 Identities = 111/333 (33%), Positives = 124/333 (37%), Gaps = 65/333 (19%)

Query: 71  PQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRA 130
           PQ  S +G NK  G          PP  G     G P   P G+     G   QG  SR 
Sbjct: 36  PQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPP---PPGKPQ---GPPPQGDKSR- 88

Query: 131 PSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPT-------PPPPP 183
            SPR P     GP      P+ GN  +        PP P  P  PPP        PPPP 
Sbjct: 89  -SPRSPPGKPQGP-----PPQGGNQPQG------PPPPPGKPQGPPPQGGNRPQGPPPPG 136

Query: 184 PPLPPPLPSSSPIKTPLVSPPG-----PLTKGNLPVVAPPVPCAPPPPPP--------PP 230
            P  PP P     ++P  SPPG     P   GN P   PP P  P  PPP        PP
Sbjct: 137 KPQGPP-PQGDKSRSPR-SPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGKKPQGPP 194

Query: 231 PPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPA-QDAQEP 289
           PP  P  PP     DK+   Q +P   P  PPP     P G P    +P  P  Q   +P
Sbjct: 195 PPGKPQGPPPQ--GDKSRSSQ-SPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKP 251

Query: 290 PAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSP------SFQAPPQKAGAQ 343
             PPPP  P            P   G  S S   PP  P+ P      + Q PP  AG  
Sbjct: 252 QGPPPPGKPQGP---------PAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGN 302

Query: 344 ALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPP 376
               P APP  QP    +   RP  GG    PP
Sbjct: 303 P-QQPQAPPAGQP----QGPPRPPQGGRPSRPP 330



 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 104/361 (28%), Positives = 121/361 (33%), Gaps = 101/361 (27%)

Query: 2   PVPPPPPPPLPPPPP--------------PLGAPPPPPPSAPPVSTDTSSLRRADPKGRS 47
           P P     P  PPPP              P G PPP  P  PP   D S   R+ P    
Sbjct: 39  PSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPP---- 94

Query: 48  ALLADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFP 107
                                  PQ    +G N+  G          PP  G     G P
Sbjct: 95  ---------------------GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNRPQGPP 133

Query: 108 VLRPAGQRDVAGGKTGQGP---GSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAART 164
              P G+         QGP   G ++ SPR P     GP      P+ GN  +       
Sbjct: 134 ---PPGK--------PQGPPPQGDKSRSPRSPPGKPQGP-----PPQGGNQPQG------ 171

Query: 165 APPRPNVPAPPPPT-------PPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAP 217
            PP P  P  PPP        PPPP  P  PP P     ++   SPPG       P   P
Sbjct: 172 PPPPPGKPQGPPPQGGKKPQGPPPPGKPQGPP-PQGDKSRSS-QSPPGK------PQGPP 223

Query: 218 PVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKA 277
           P     P  PPPPP  P   PP         KPQ       P PP  P  PP       A
Sbjct: 224 PQGGNQPQGPPPPPGKPQGPPPQG-----GNKPQ------GPPPPGKPQGPP-------A 265

Query: 278 EPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPP 337
           +  S +Q A+ PP  P   P     +P+   P PP  G     + PP   P+ P    PP
Sbjct: 266 QGGSKSQSARSPPGKPQGPPQQEGNNPQG--PPPPAGGNPQQPQAPPAGQPQGP--PRPP 321

Query: 338 Q 338
           Q
Sbjct: 322 Q 322


>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
            sapiens]
          Length = 1362

 Score =  110 bits (275), Expect = 3e-24
 Identities = 107/353 (30%), Positives = 125/353 (35%), Gaps = 95/353 (26%)

Query: 159  HGAARTAP-PRPNVPAPPPPTPPPPPPPL------PPPLPSSSPIKTP--LVSPPGPLTK 209
            H   + AP P P  P PPP  PPPPPPP       PPP P S P +    + S P P   
Sbjct: 743  HQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIA 802

Query: 210  GNLPVVAP--------------------PVPCAPPP-PPPPPPPTPPPLPPASVLSDKAV 248
              +PV+ P                    P P  PP  P PP   TPP L   +V+S  A+
Sbjct: 803  TQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPAL 862

Query: 249  KPQLA-----PLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPA-----PPPPLPP 298
               L      P +     PP P  PP   P L   P  P     +PP        PP PP
Sbjct: 863  HNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPP 922

Query: 299  YASCSPRASL--------PAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQAL---PA 347
              S   +  L        P P LP V   S+ PPPLPP       PP  +  Q L   P 
Sbjct: 923  LTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPP-------PPHPSVQQQLQQQPP 975

Query: 348  PPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQAT---AWTPTQQP 404
            PP PP  QP  Q++             PPP P    P  + S+  QQ        P   P
Sbjct: 976  PPPPPQPQPPPQQQHQ-----------PPPRPVHLQPM-QFSTHIQQPPPPQGQQPPHPP 1023

Query: 405  GGQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRTPGPW 457
             GQ                        PPP   KP Q I     PR     P+
Sbjct: 1024 PGQQP----------------------PPPQPAKPQQVIQHHHSPRHHKSDPY 1054



 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 111/383 (28%), Positives = 136/383 (35%), Gaps = 92/383 (24%)

Query: 2    PVP--PPPPPPLPPPPPP-----LGAPPPPPPSAP----------PVSTDTSSLRRADPK 44
            PVP  PPPPP  PPPPPP        PPPPPPS P          P     + +   +P+
Sbjct: 752  PVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQ 811

Query: 45   GRSALLADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAG 104
               ++   I   T+      I     P++        E          STPP L      
Sbjct: 812  LPGSVFDPIGHFTQ-----PILHLPQPELPPHLPQPPE---------HSTPPHLNQHAVV 857

Query: 105  GFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPA-SPRLGNTSEAHGAAR 163
              P L  A  +  +       P +RA +  LP K    P  PPA SP L  T        
Sbjct: 858  SPPALHNALPQQPS------RPSNRAAA--LPPK----PARPPAVSPALTQTPLLPQPPM 905

Query: 164  TAPPRPNVPAPPPPTPP----------------PPPPPLPPPLPSSSPIKTPLVSPPGPL 207
              PP+  +    PP PP                 PP PL P +   S    PL  PP P 
Sbjct: 906  AQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPS 965

Query: 208  TKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLL 267
             +  L    PP    PPPP P PPP     PP   +    ++P     H+   PPP    
Sbjct: 966  VQQQLQQQPPP----PPPPQPQPPPQQQHQPPPRPVH---LQPMQFSTHIQQPPPPQGQQ 1018

Query: 268  PPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYA---SCSPRASLPAPPLPGVNSSSETPP 324
            PP   PG            Q+PP P P  P        SPR     P   G     E P 
Sbjct: 1019 PPHPPPG------------QQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTG--HLREAPS 1064

Query: 325  PLPPKSP--------SFQAPPQK 339
            PL   SP        + Q+PPQ+
Sbjct: 1065 PLMIHSPQMSQFQSLTHQSPPQQ 1087



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 105/417 (25%), Positives = 145/417 (34%), Gaps = 57/417 (13%)

Query: 2    PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKG----------RSALLA 51
            P PPPP  P    P    +PPP   +  PV          DP G          +  L  
Sbjct: 778  PPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPP 837

Query: 52   DIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRP 111
             + Q         +N  +     +      +     + R A+ PP             +P
Sbjct: 838  HLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPP-------------KP 884

Query: 112  AGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAH--GAARTAPPRP 169
            A    V+   T Q P    P    P + +     PPA P      + +     +  PP P
Sbjct: 885  ARPPAVSPALT-QTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTP 943

Query: 170  NVPA------PPPPTPPPP-----------PPPLPPPLPSSSPIKTPLVSPPGPL----T 208
             +P+      PPPP PPPP           PPP PPP P   P +     PP P+     
Sbjct: 944  LLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPP-QQQHQPPPRPVHLQPM 1002

Query: 209  KGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLP 268
            + +  +  PP P    PP PPP   PPP  PA     + ++   +P H    P     L 
Sbjct: 1003 QFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAK--PQQVIQHHHSPRHHKSDPYSTGHLR 1060

Query: 269  PCGYPGLKAEP-ASPAQDAQEPPAPPPPLPPYASCSPRASLPAP-PLPGVNSSSETPPPL 326
                P +   P  S  Q       P   + P       AS+  P PL  V       P +
Sbjct: 1061 EAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPII 1120

Query: 327  --PPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLN-PPPAPP 380
               P SPS +  P K   +++ AP   P  +P ++    GRP     + N PPP  P
Sbjct: 1121 RSEPFSPSLRPEPPK-HPESIKAPVHLP-QRPEMKPVDVGRPVIRPPEQNAPPPGAP 1175



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 53/167 (31%), Positives = 71/167 (42%), Gaps = 34/167 (20%)

Query: 147 PASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGP 206
           P    + NT++A    +T  P+PN   PP    P P P + P L   +P+ T  V PP P
Sbjct: 191 PGVSTVPNTTQASTPPQTQTPQPN--PPPVQATPHPFPAVTPDLIVQTPVMT--VVPPQP 246

Query: 207 LTKGNLPVVAPPVPCAPPPPPPPPPPTPPPL---PPASVLSDKAVKPQ------------ 251
           L         PPVP   P P PPP P P P+   PP    + + VK +            
Sbjct: 247 LQ------TPPPVP---PQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTP 297

Query: 252 --LAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQ----DAQEPPAP 292
             + P+H PP  PP P     G     + P  P +    D+Q+ PAP
Sbjct: 298 TTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAP 344



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 63/266 (23%), Positives = 91/266 (34%), Gaps = 37/266 (13%)

Query: 3    VPPPPPPPLPPPPPP------LGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQG 56
            V   PPPPLPPPP P         PPPPPP  P         ++  P  R   L  +Q  
Sbjct: 950  VQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQP----QPPPQQQHQPPPRPVHLQPMQFS 1005

Query: 57   TRLRKVTQINDRSAPQ---------IESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFP 107
            T +++      +  P           + +K         +     S P + G L     P
Sbjct: 1006 THIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSP 1065

Query: 108  VLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPP 167
            ++  + Q       T Q P  +   P+   +  +  ++ P    +    + H     +P 
Sbjct: 1066 LMIHSPQMSQFQSLTHQSPPQQNVQPK-KQELRAASVVQPQPLVVVKEEKIH-----SPI 1119

Query: 168  RPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKG---NLPVVAPPVPCAPP 224
              + P  P   P PP  P          IK P+  P  P  K      PV+ PP   APP
Sbjct: 1120 IRSEPFSPSLRPEPPKHP--------ESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPP 1171

Query: 225  P-PPPPPPPTPPPLPPASVLSDKAVK 249
            P  P        P  P +   D  +K
Sbjct: 1172 PGAPDKDKQKQEPKTPVAPKKDLKIK 1197



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 79/348 (22%), Positives = 111/348 (31%), Gaps = 55/348 (15%)

Query: 1    MPVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLR 60
            +P  P  PP + P        P PP + PP       +   D +  +  L  +Q    L+
Sbjct: 880  LPPKPARPPAVSPALTQTPLLPQPPMAQPP------QVLLEDEEPPAPPLTSMQMQLYLQ 933

Query: 61   KVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGG 120
            ++ ++     P + S K               S PP          P L P     V   
Sbjct: 934  QLQKVQP-PTPLLPSVK-------------VQSQPP----------PPLPPPPHPSVQQQ 969

Query: 121  KTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPP 180
               Q P    P P+ P +    P  PP    L     +    +  PP+   P  PPP   
Sbjct: 970  LQQQPPPPPPPQPQPPPQQQHQP--PPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQ 1027

Query: 181  PPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPP------------PPPP 228
            PPPP    P        +P      P + G+L     P+    P            PP  
Sbjct: 1028 PPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQ 1087

Query: 229  PPPPTPPPLPPASVLSDK-AVKPQLAPLHLP-----PIPPPLPLLPPCGYPGLKAEPASP 282
               P    L  ASV+  +  V  +   +H P     P  P L   PP     +KA    P
Sbjct: 1088 NVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESIKA----P 1143

Query: 283  AQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETP-PPLPPK 329
                Q P   P  +       P  + P P  P  +   + P  P+ PK
Sbjct: 1144 VHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPK 1191



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 48/176 (27%), Positives = 64/176 (36%), Gaps = 35/176 (19%)

Query: 204 PGPLTKGNLPVVA-PPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQL-APLHLPPIP 261
           PG  T  N    + PP    P P PPP   TP P P        AV P L     +  + 
Sbjct: 191 PGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFP--------AVTPDLIVQTPVMTVV 242

Query: 262 PPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSE 321
           PP PL  P   P     P +PA      P P    PP  + +P+   P     GV   ++
Sbjct: 243 PPQPLQTPPPVPPQPQPPPAPA------PQPVQSHPPIIAATPQ---PVKTKKGVKRKAD 293

Query: 322 T-----------PPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRP 366
           T           PP LPP+  +      K G +   + P  P  +     ++H  P
Sbjct: 294 TTTPTTIDPIHEPPSLPPEPKT-----TKLGQRRESSRPVKPPKKDVPDSQQHPAP 344



 Score = 36.6 bits (83), Expect = 0.052
 Identities = 21/55 (38%), Positives = 22/55 (40%), Gaps = 13/55 (23%)

Query: 1   MPVPPPPPPPLPPPPPPLGAPPPPPPSAP-------------PVSTDTSSLRRAD 42
           M V PP P   PPP PP   PPP P   P             PV T     R+AD
Sbjct: 239 MTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKAD 293



 Score = 32.7 bits (73), Expect = 0.75
 Identities = 27/88 (30%), Positives = 40/88 (45%), Gaps = 8/88 (9%)

Query: 1   MPVPPPPP-----PPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQ 55
           MP  P  P      P  PPP  + APP    S+   S+D+ S      + R+  LA++Q+
Sbjct: 457 MPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQE 516

Query: 56  GTRLRKV-TQINDRSAPQIESSKGTNKE 82
             +L+ V  Q+   S PQ    K   K+
Sbjct: 517 --QLKAVHEQLAALSQPQQNKPKKKEKD 542


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score =  105 bits (262), Expect = 9e-23
 Identities = 101/382 (26%), Positives = 131/382 (34%), Gaps = 58/382 (15%)

Query: 4    PPPP------PPPLPPPPPPLGAPPPPPP---SAPPVSTDTSSLRRADPKGRSALLADIQ 54
            P PP      PPP   P PP+     PPP    +PP+ST T+      P           
Sbjct: 1422 PSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPISTTTTPPPTTTP----------- 1470

Query: 55   QGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQ 114
                          S P    S  T      +  T   + PPT         P+  PA  
Sbjct: 1471 --------------SPPTTTPSPPTTTPSPPTTTT--TTPPPTTTPSPPTTTPITPPAST 1514

Query: 115  RDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAP 174
              +    T   P +   +P  P  T S P   P +P    T+       T  P P     
Sbjct: 1515 TTLPPTTTPSPPTTTTTTPP-PTTTPSPPTTTPITPPTSTTTLP--PTTTPSPPPTTTTT 1571

Query: 175  PPPTPPPPPP----PLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPP- 229
            PPPT  P PP    P PP + +++P  T   SPP   T    P   P  P   P  PP  
Sbjct: 1572 PPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTS 1631

Query: 230  ----PPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPP--PLPLLPPCGYPG--LKAEPAS 281
                PP T P  PP +  +         P    P PP       PP   P   +   P+ 
Sbjct: 1632 TTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSP 1691

Query: 282  PAQDAQEP-PAPPPPLPPYASCSPRA-SLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQK 339
            P      P P   P  P   + +P + + P+PP   + + S T  P PP +     PP  
Sbjct: 1692 PTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTT 1751

Query: 340  AGA--QALPAPPA--PPGSQPF 357
              +     P PP+  PP   PF
Sbjct: 1752 TSSPLTTTPLPPSITPPTFSPF 1773



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 79/300 (26%), Positives = 98/300 (32%), Gaps = 24/300 (8%)

Query: 122  TGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPP 181
            T   P +  PSP   + T   P   P+ P    T+       + P       PP  TP P
Sbjct: 1397 TTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSP 1456

Query: 182  P------PPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPP 235
            P      PPP   P P ++    P  +P  P T         P P   P PP   P TPP
Sbjct: 1457 PISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTT-----TTTTPPPTTTPSPPTTTPITPP 1511

Query: 236  ----PLPPASVLSDKAVKPQLAPLHLPPIPP-PLPLLPPCGYPGL--KAEPASPAQDAQE 288
                 LPP +  S         P    P PP   P+ PP     L     P+ P      
Sbjct: 1512 ASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTT 1571

Query: 289  PPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAP 348
            PP    P P      P  + P+PP     +   T  P PP + +   PP    +     P
Sbjct: 1572 PPPTTTPSP------PTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTP 1625

Query: 349  PAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQPGGQL 408
              PP S   L       P        PP   P+   TT  S      T   PT  P   +
Sbjct: 1626 ITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPI 1685



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 88/311 (28%), Positives = 109/311 (35%), Gaps = 62/311 (19%)

Query: 126  PGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPP--- 182
            P +  PSP +   T   P   P SP +  T        T PP    P+PP  TP PP   
Sbjct: 1433 PPTTTPSPPITTTTTPPPTTTP-SPPISTT--------TTPPPTTTPSPPTTTPSPPTTT 1483

Query: 183  --PP----PLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVP-----CAPPPPPPPPP 231
              PP      PPP  + SP  T  ++PP   T   LP    P P       PPP   P P
Sbjct: 1484 PSPPTTTTTTPPPTTTPSPPTTTPITPPASTT--TLPPTTTPSPPTTTTTTPPPTTTPSP 1541

Query: 232  PTPPPL-PPASVLSDKAVKPQLAPLHLPPIPPPLPLLPP---CGYPGLKAEPASPAQDAQ 287
            PT  P+ PP S  +       L P   P  PP     PP      P     P+ P     
Sbjct: 1542 PTTTPITPPTSTTT-------LPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTT 1594

Query: 288  EPP---APPPPL------PPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQ 338
             PP    P PP       PP  + SP  + P  P     +   T  P PP + +   PP 
Sbjct: 1595 TPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPT 1654

Query: 339  KAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP-TTELSSKSQQATA 397
               +      P+PP +                    PPP     SP TT  S  +   T 
Sbjct: 1655 TTPSPPTTTTPSPPITT----------------TTTPPPTTTPSSPITTTPSPPTTTMTT 1698

Query: 398  WTPTQQPGGQL 408
             +PT  P   +
Sbjct: 1699 PSPTTTPSSPI 1709



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 86/349 (24%), Positives = 104/349 (29%), Gaps = 87/349 (24%)

Query: 2    PVPPP------PPPPLPPPPPPLGAPPPP-----PPSAPPVSTDTSSLRRADPKGRSALL 50
            P+ PP      PP   P PP      PPP     PP+  P++  TS+             
Sbjct: 1507 PITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTST------------- 1553

Query: 51   ADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLR 110
                  T L   T      +P   ++         S  T    +PPT+            
Sbjct: 1554 ------TTLPPTT----TPSPPPTTTTTPPPTTTPSPPTTTTPSPPTI------------ 1591

Query: 111  PAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPN 170
                       T   P +  PSP     T   P   P+ P               PP   
Sbjct: 1592 ----------TTTTPPPTTTPSPPTTTTTTPPPTTTPSPPT---------TTPITPPTST 1632

Query: 171  VPAPPPPTPPPPP--PPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPP 228
               PP  TP PPP     PPP  + SP  T   SPP   T    P   P  P    P PP
Sbjct: 1633 TTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPP 1692

Query: 229  PPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQE 288
                T P   P +  S              P PPP  +  P           SP      
Sbjct: 1693 TTTMTTP--SPTTTPSSPITTTTTPSSTTTPSPPPTTMTTP-----------SPTTTPSP 1739

Query: 289  PPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPP 337
            P      LPP  + SP  + P PP       S TPP   P S +    P
Sbjct: 1740 PTTTMTTLPPTTTSSPLTTTPLPP-------SITPPTFSPFSTTTPTTP 1781



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 54/196 (27%), Positives = 69/196 (35%), Gaps = 28/196 (14%)

Query: 217  PPVPCAPPPPPPPPPPTPPP-----LPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCG 271
            P   C   P PP   P+PPP     LPP +  S     P       PP   P P +    
Sbjct: 1391 PMDKCITTPSPPTTTPSPPPTSTTTLPPTTTPS----PPTTTTTTPPPTTTPSPPITTTT 1446

Query: 272  YPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSP 331
             P     P+ P      PP    P PP  + SP  + P+PP     +++ TPPP    SP
Sbjct: 1447 TPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPP----TTTTTTPPPTTTPSP 1502

Query: 332  SFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPP---PAPPARSPTTEL 388
                            P  PP S   L       P        PP   P+PP  +P T  
Sbjct: 1503 ------------PTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPP 1550

Query: 389  SSKSQQATAWTPTQQP 404
            +S +      TP+  P
Sbjct: 1551 TSTTTLPPTTTPSPPP 1566



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 69/283 (24%), Positives = 87/283 (30%), Gaps = 41/283 (14%)

Query: 2    PVPPPPPPPLPP------PPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQ 55
            P PP   P  PP      PP    +PPP   + PP +T  S      P   +        
Sbjct: 1539 PSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPP 1598

Query: 56   GTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQR 115
             T     T       P    S  T        +T   + PPT         P   P    
Sbjct: 1599 TTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTST--TTLPPTTT-------PSPPPTTTT 1649

Query: 116  DVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPR--PNVPA 173
                  T   P +  PSP +   T   P   P+SP     S       T  P   P+ P 
Sbjct: 1650 TPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPI 1709

Query: 174  PPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPP--PPPPPPP 231
                TP     P PPP   ++P  +P  +P  P T        PP   + P    P PP 
Sbjct: 1710 TTTTTPSSTTTPSPPPTTMTTP--SPTTTPSPPTT---TMTTLPPTTTSSPLTTTPLPPS 1764

Query: 232  PTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPG 274
             TPP   P S  +                 P  P +P C + G
Sbjct: 1765 ITPPTFSPFSTTT-----------------PTTPCVPLCNWTG 1790



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 66/286 (23%), Positives = 88/286 (30%), Gaps = 60/286 (20%)

Query: 136  PNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNV-PAPPPPTPPPPPPPLPPPLPSSS 194
            P  T +G   P  +P    T+       T    P   P     T  P P P     P+++
Sbjct: 4071 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 4130

Query: 195  PIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP-----PTPPPLPPASVLSDKAVK 249
            PI T     P P   G       P+       P P P     PT  P+   + ++     
Sbjct: 4131 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT----- 4185

Query: 250  PQLAPLHLPPIPPPLPLLPPCGYP-GLKAEPASPAQDAQEPPAPPPPLPPYASCSP---R 305
                       P P P     G P      P +    +  PP    P    ++ SP    
Sbjct: 4186 -----------PTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTES 4234

Query: 306  ASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGR 365
             +L +   P +  +S  PP  P       AP   +G   L  PP+   S           
Sbjct: 4235 TTLLSTLPPAIEMTSTAPPSTP------TAPTTTSGGHTLSPPPSTTTS----------- 4277

Query: 366  PGAGGGKLNPPPAPPARSPTTELSSKSQQAT-------AWTPTQQP 404
                      PP  P R  TT  SS    +T       AWTPT  P
Sbjct: 4278 ----------PPGTPTRGTTTGSSSAPTPSTVQTTTTSAWTPTPTP 4313



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 84/413 (20%), Positives = 120/413 (29%), Gaps = 51/413 (12%)

Query: 23   PPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSAPQIESSKGTNKE 82
            P PP+  P++T T+      P G           T +   T +     P    +  T   
Sbjct: 1893 PTPPTTTPITTTTTVTPTPTPTG-----TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 1947

Query: 83   GGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISG 142
               +  T    TP   G       P+        V    T  G  +   +P     T++ 
Sbjct: 1948 ---TTTTTVTPTPTPTGTQTPTTTPITTTT---TVTPTPTPTGTQTPTTTPITTTTTVTP 2001

Query: 143  PLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTP-------PPPPPPLPPPLPSSSP 195
               P  +     T        T  P P     P  TP        P P P     P+++P
Sbjct: 2002 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2061

Query: 196  IKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP-----PTPPPLPPASVLSDKAV-- 248
            I T     P P   G       P+       P P P     PT  P+   + ++      
Sbjct: 2062 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2121

Query: 249  ---KPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAP----PPPLPPYAS 301
                P   P+       P P   P G       P +        P P     P   P  +
Sbjct: 2122 GTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2179

Query: 302  CSPRASLPAP-------PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGS 354
             +     P P         P   +++ TP P P  + +    P        P  P P G+
Sbjct: 2180 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-PTPTGT 2238

Query: 355  QPFLQKKRHGRPGAGGGKLNPPPAPP-ARSPTTELSSKSQQATAWTPTQQPGG 406
            Q          P      + P P P   ++PTT   +     T  TPT  P G
Sbjct: 2239 Q-----TPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTPTPTPTG 2283



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 92/442 (20%), Positives = 133/442 (30%), Gaps = 57/442 (12%)

Query: 5    PPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQ 64
            P PPP     P P   P PP  +   +   T+S     P   + L   I   T     T 
Sbjct: 1721 PSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTS----SPLTTTPLPPSITPPTFSPFSTT 1776

Query: 65   INDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPV---LRPAGQRDVAGGK 121
                    + +  G    G  + +  G  T   +GD+   G+      R     DV  G+
Sbjct: 1777 TPTTPCVPLCNWTGWLDSGKPNFHKPGGDTE-LIGDVCGPGWAANISCRATMYPDVPIGQ 1835

Query: 122  TGQG-----------------PGSRAPSPRLPNKTISGPL---IPPASPRLGNTSEAHGA 161
             GQ                  PG   P     N  I+      +   +     T+E    
Sbjct: 1836 LGQTVVCDVSVGLICKNEDQKPGGVIPMAFCLNYEINVQCCECVTQPTTMTTTTTENPTP 1895

Query: 162  ARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPC 221
              T P        P PTP     P   P+ +++ + TP  +P G  T    P+       
Sbjct: 1896 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV-TPTPTPTGTQTPTTTPITTTTTVT 1954

Query: 222  APPPPPPPPPPTPPPLPPASVLSDKAV-----KPQLAPLHLPPIPPPLPLLPPCGYPGLK 276
              P P     PT  P+   + ++          P   P+       P P   P G     
Sbjct: 1955 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPT 2012

Query: 277  AEPASPAQDAQEPPAP----PPPLPPYASCSPRASLPAP-------PLPGVNSSSETPPP 325
              P +        P P     P   P  + +     P P         P   +++ TP P
Sbjct: 2013 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2072

Query: 326  LPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPP-ARSP 384
             P  + +    P        P  P P G+Q          P      + P P P   ++P
Sbjct: 2073 TPTGTQTPTTTPITTTTTVTPT-PTPTGTQ-----TPTTTPITTTTTVTPTPTPTGTQTP 2126

Query: 385  TTELSSKSQQATAWTPTQQPGG 406
            TT   +     T  TPT  P G
Sbjct: 2127 TT---TPITTTTTVTPTPTPTG 2145



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 64/294 (21%), Positives = 89/294 (30%), Gaps = 34/294 (11%)

Query: 136  PNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNV-PAPPPPTPPPPPPPLPPPLPSSS 194
            P  T +G   P  +P    T+       T    P   P     T  P P P     P+++
Sbjct: 2047 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2106

Query: 195  PIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP-----PTPPPLPPASVLSDKAV- 248
            PI T     P P   G       P+       P P P     PT  P+   + ++     
Sbjct: 2107 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2166

Query: 249  ----KPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAP----PPPLPPYA 300
                 P   P+       P P   P G       P +        P P     P   P  
Sbjct: 2167 TGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2224

Query: 301  SCSPRASLPAP-------PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPG 353
            + +     P P         P   +++ TP P P  + +    P        P  P P G
Sbjct: 2225 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-PTPTG 2283

Query: 354  SQPFLQKKRHGRPGAGGGKLNPPPAPP-ARSPTTELSSKSQQATAWTPTQQPGG 406
            +Q          P      + P P P   ++PTT   +     T  TPT  P G
Sbjct: 2284 TQ-----TPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTPTPTPTG 2329



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 64/294 (21%), Positives = 89/294 (30%), Gaps = 34/294 (11%)

Query: 136  PNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNV-PAPPPPTPPPPPPPLPPPLPSSS 194
            P  T +G   P  +P    T+       T    P   P     T  P P P     P+++
Sbjct: 2231 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2290

Query: 195  PIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP-----PTPPPLPPASVLSDKAV- 248
            PI T     P P   G       P+       P P P     PT  P+   + ++     
Sbjct: 2291 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2350

Query: 249  ----KPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAP----PPPLPPYA 300
                 P   P+       P P   P G       P +        P P     P   P  
Sbjct: 2351 TGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2408

Query: 301  SCSPRASLPAP-------PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPG 353
            + +     P P         P   +++ TP P P  + +    P        P  P P G
Sbjct: 2409 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-PTPTG 2467

Query: 354  SQPFLQKKRHGRPGAGGGKLNPPPAPP-ARSPTTELSSKSQQATAWTPTQQPGG 406
            +Q          P      + P P P   ++PTT   +     T  TPT  P G
Sbjct: 2468 TQ-----TPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTPTPTPTG 2513



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 64/294 (21%), Positives = 89/294 (30%), Gaps = 34/294 (11%)

Query: 136  PNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNV-PAPPPPTPPPPPPPLPPPLPSSS 194
            P  T +G   P  +P    T+       T    P   P     T  P P P     P+++
Sbjct: 2415 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2474

Query: 195  PIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP-----PTPPPLPPASVLSDKAV- 248
            PI T     P P   G       P+       P P P     PT  P+   + ++     
Sbjct: 2475 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2534

Query: 249  ----KPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAP----PPPLPPYA 300
                 P   P+       P P   P G       P +        P P     P   P  
Sbjct: 2535 TGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2592

Query: 301  SCSPRASLPAP-------PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPG 353
            + +     P P         P   +++ TP P P  + +    P        P  P P G
Sbjct: 2593 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-PTPTG 2651

Query: 354  SQPFLQKKRHGRPGAGGGKLNPPPAPP-ARSPTTELSSKSQQATAWTPTQQPGG 406
            +Q          P      + P P P   ++PTT   +     T  TPT  P G
Sbjct: 2652 TQ-----TPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTPTPTPTG 2697



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 64/294 (21%), Positives = 89/294 (30%), Gaps = 34/294 (11%)

Query: 136  PNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNV-PAPPPPTPPPPPPPLPPPLPSSS 194
            P  T +G   P  +P    T+       T    P   P     T  P P P     P+++
Sbjct: 2599 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2658

Query: 195  PIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP-----PTPPPLPPASVLSDKAV- 248
            PI T     P P   G       P+       P P P     PT  P+   + ++     
Sbjct: 2659 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2718

Query: 249  ----KPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAP----PPPLPPYA 300
                 P   P+       P P   P G       P +        P P     P   P  
Sbjct: 2719 TGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2776

Query: 301  SCSPRASLPAP-------PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPG 353
            + +     P P         P   +++ TP P P  + +    P        P  P P G
Sbjct: 2777 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-PTPTG 2835

Query: 354  SQPFLQKKRHGRPGAGGGKLNPPPAPP-ARSPTTELSSKSQQATAWTPTQQPGG 406
            +Q          P      + P P P   ++PTT   +     T  TPT  P G
Sbjct: 2836 TQ-----TPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTPTPTPTG 2881



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 64/294 (21%), Positives = 89/294 (30%), Gaps = 34/294 (11%)

Query: 136  PNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNV-PAPPPPTPPPPPPPLPPPLPSSS 194
            P  T +G   P  +P    T+       T    P   P     T  P P P     P+++
Sbjct: 2783 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2842

Query: 195  PIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP-----PTPPPLPPASVLSDKAV- 248
            PI T     P P   G       P+       P P P     PT  P+   + ++     
Sbjct: 2843 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2902

Query: 249  ----KPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAP----PPPLPPYA 300
                 P   P+       P P   P G       P +        P P     P   P  
Sbjct: 2903 TGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2960

Query: 301  SCSPRASLPAP-------PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPG 353
            + +     P P         P   +++ TP P P  + +    P        P  P P G
Sbjct: 2961 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-PTPTG 3019

Query: 354  SQPFLQKKRHGRPGAGGGKLNPPPAPP-ARSPTTELSSKSQQATAWTPTQQPGG 406
            +Q          P      + P P P   ++PTT   +     T  TPT  P G
Sbjct: 3020 TQ-----TPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTPTPTPTG 3065



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 64/294 (21%), Positives = 89/294 (30%), Gaps = 34/294 (11%)

Query: 136  PNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNV-PAPPPPTPPPPPPPLPPPLPSSS 194
            P  T +G   P  +P    T+       T    P   P     T  P P P     P+++
Sbjct: 2967 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3026

Query: 195  PIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP-----PTPPPLPPASVLSDKAV- 248
            PI T     P P   G       P+       P P P     PT  P+   + ++     
Sbjct: 3027 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3086

Query: 249  ----KPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAP----PPPLPPYA 300
                 P   P+       P P   P G       P +        P P     P   P  
Sbjct: 3087 TGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3144

Query: 301  SCSPRASLPAP-------PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPG 353
            + +     P P         P   +++ TP P P  + +    P        P  P P G
Sbjct: 3145 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-PTPTG 3203

Query: 354  SQPFLQKKRHGRPGAGGGKLNPPPAPP-ARSPTTELSSKSQQATAWTPTQQPGG 406
            +Q          P      + P P P   ++PTT   +     T  TPT  P G
Sbjct: 3204 TQ-----TPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTPTPTPTG 3249



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 64/294 (21%), Positives = 89/294 (30%), Gaps = 34/294 (11%)

Query: 136  PNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNV-PAPPPPTPPPPPPPLPPPLPSSS 194
            P  T +G   P  +P    T+       T    P   P     T  P P P     P+++
Sbjct: 3151 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3210

Query: 195  PIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP-----PTPPPLPPASVLSDKAV- 248
            PI T     P P   G       P+       P P P     PT  P+   + ++     
Sbjct: 3211 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3270

Query: 249  ----KPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAP----PPPLPPYA 300
                 P   P+       P P   P G       P +        P P     P   P  
Sbjct: 3271 TGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3328

Query: 301  SCSPRASLPAP-------PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPG 353
            + +     P P         P   +++ TP P P  + +    P        P  P P G
Sbjct: 3329 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-PTPTG 3387

Query: 354  SQPFLQKKRHGRPGAGGGKLNPPPAPP-ARSPTTELSSKSQQATAWTPTQQPGG 406
            +Q          P      + P P P   ++PTT   +     T  TPT  P G
Sbjct: 3388 TQ-----TPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTPTPTPTG 3433



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 64/294 (21%), Positives = 89/294 (30%), Gaps = 34/294 (11%)

Query: 136  PNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNV-PAPPPPTPPPPPPPLPPPLPSSS 194
            P  T +G   P  +P    T+       T    P   P     T  P P P     P+++
Sbjct: 3335 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3394

Query: 195  PIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP-----PTPPPLPPASVLSDKAV- 248
            PI T     P P   G       P+       P P P     PT  P+   + ++     
Sbjct: 3395 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3454

Query: 249  ----KPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAP----PPPLPPYA 300
                 P   P+       P P   P G       P +        P P     P   P  
Sbjct: 3455 TGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3512

Query: 301  SCSPRASLPAP-------PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPG 353
            + +     P P         P   +++ TP P P  + +    P        P  P P G
Sbjct: 3513 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-PTPTG 3571

Query: 354  SQPFLQKKRHGRPGAGGGKLNPPPAPP-ARSPTTELSSKSQQATAWTPTQQPGG 406
            +Q          P      + P P P   ++PTT   +     T  TPT  P G
Sbjct: 3572 TQ-----TPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTPTPTPTG 3617



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 64/294 (21%), Positives = 89/294 (30%), Gaps = 34/294 (11%)

Query: 136  PNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNV-PAPPPPTPPPPPPPLPPPLPSSS 194
            P  T +G   P  +P    T+       T    P   P     T  P P P     P+++
Sbjct: 3519 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3578

Query: 195  PIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP-----PTPPPLPPASVLSDKAV- 248
            PI T     P P   G       P+       P P P     PT  P+   + ++     
Sbjct: 3579 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3638

Query: 249  ----KPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAP----PPPLPPYA 300
                 P   P+       P P   P G       P +        P P     P   P  
Sbjct: 3639 TGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3696

Query: 301  SCSPRASLPAP-------PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPG 353
            + +     P P         P   +++ TP P P  + +    P        P  P P G
Sbjct: 3697 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-PTPTG 3755

Query: 354  SQPFLQKKRHGRPGAGGGKLNPPPAPP-ARSPTTELSSKSQQATAWTPTQQPGG 406
            +Q          P      + P P P   ++PTT   +     T  TPT  P G
Sbjct: 3756 TQ-----TPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTPTPTPTG 3801



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 64/294 (21%), Positives = 89/294 (30%), Gaps = 34/294 (11%)

Query: 136  PNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNV-PAPPPPTPPPPPPPLPPPLPSSS 194
            P  T +G   P  +P    T+       T    P   P     T  P P P     P+++
Sbjct: 3703 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3762

Query: 195  PIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP-----PTPPPLPPASVLSDKAV- 248
            PI T     P P   G       P+       P P P     PT  P+   + ++     
Sbjct: 3763 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3822

Query: 249  ----KPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAP----PPPLPPYA 300
                 P   P+       P P   P G       P +        P P     P   P  
Sbjct: 3823 TGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3880

Query: 301  SCSPRASLPAP-------PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPG 353
            + +     P P         P   +++ TP P P  + +    P        P  P P G
Sbjct: 3881 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-PTPTG 3939

Query: 354  SQPFLQKKRHGRPGAGGGKLNPPPAPP-ARSPTTELSSKSQQATAWTPTQQPGG 406
            +Q          P      + P P P   ++PTT   +     T  TPT  P G
Sbjct: 3940 TQ-----TPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTPTPTPTG 3985



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 64/294 (21%), Positives = 89/294 (30%), Gaps = 34/294 (11%)

Query: 136  PNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNV-PAPPPPTPPPPPPPLPPPLPSSS 194
            P  T +G   P  +P    T+       T    P   P     T  P P P     P+++
Sbjct: 3887 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3946

Query: 195  PIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP-----PTPPPLPPASVLSDKAV- 248
            PI T     P P   G       P+       P P P     PT  P+   + ++     
Sbjct: 3947 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 4006

Query: 249  ----KPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAP----PPPLPPYA 300
                 P   P+       P P   P G       P +        P P     P   P  
Sbjct: 4007 TGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 4064

Query: 301  SCSPRASLPAP-------PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPG 353
            + +     P P         P   +++ TP P P  + +    P        P  P P G
Sbjct: 4065 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-PTPTG 4123

Query: 354  SQPFLQKKRHGRPGAGGGKLNPPPAPP-ARSPTTELSSKSQQATAWTPTQQPGG 406
            +Q          P      + P P P   ++PTT   +     T  TPT  P G
Sbjct: 4124 TQ-----TPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTPTPTPTG 4169



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 75/355 (21%), Positives = 107/355 (30%), Gaps = 78/355 (21%)

Query: 13   PPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSAPQ 72
            P P P G   P   +  P++T T+      P G           T +   T +     P 
Sbjct: 4117 PTPTPTGTQTP---TTTPITTTTTVTPTPTPTGTQTPTT-----TPITTTTTVTPTPTPT 4168

Query: 73   IESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPS 132
                      G  +  T   +T  T+        P   P G        T  GP +   +
Sbjct: 4169 ----------GTQTPTTTPITTTTTVT-------PTPTPTG--------TQTGPPTHTST 4203

Query: 133  PRLPNKTISGPLIPPASPRLGNTS-----EAHGAARTAPPRPNVPAPPPPTPPPPPPPLP 187
              +   T S P    ++P+   ++     E+     T PP   + +  PP+ P  P    
Sbjct: 4204 APIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAPPSTPTAPTTTS 4263

Query: 188  PPLPSSSPIKTPLVSPPGPLTKGNLP--VVAPPVPCAPPPPPPPPPPTPPPLPPASVLSD 245
                 S P  T   SPPG  T+G       AP              PTP PL   S++  
Sbjct: 4264 GGHTLSPPPSTT-TSPPGTPTRGTTTGSSSAPTPSTVQTTTTSAWTPTPTPLSTPSIIRT 4322

Query: 246  KAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQ------------------ 287
              ++P            P  +L  C        P     +                    
Sbjct: 4323 TGLRPY-----------PSSVLICCVLNDTYYAPGEEVYNGTYGDTCYFVNCSLSCTLEF 4371

Query: 288  ---EPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQK 339
                 P+ P P P     +P  S P P  P    S  TP   PP+ P F  P Q+
Sbjct: 4372 YNWSCPSTPSPTP-----TPSKSTPTPSKPSSTPSKPTPGTKPPECPDFDPPRQE 4421



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 64/275 (23%), Positives = 84/275 (30%), Gaps = 55/275 (20%)

Query: 2    PVPPPPPPPLPPPPPPLGAP--------PPPPPSAPPVSTDTSSLRRADPKGRSALLADI 53
            P P P      PP     AP        PPP  S P  S  TSS         + LL+ +
Sbjct: 4186 PTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTES----TTLLSTL 4241

Query: 54   QQGTRLRKVTQINDRSAPQIES---------SKGTNKEG----GGSANTRGASTPPTLGD 100
                 +      +  +AP   S         S  T+  G    G +  +  A TP T+  
Sbjct: 4242 PPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQT 4301

Query: 101  LFAGGF-PVLRPAGQRDVAGGKTGQGPGSR-------------APSPRLPNKTISGPLIP 146
                 + P   P     +    TG  P                AP   + N T  G    
Sbjct: 4302 TTTSAWTPTPTPLSTPSIIR-TTGLRPYPSSVLICCVLNDTYYAPGEEVYNGTY-GDTCY 4359

Query: 147  PASPRLGNTSEAHGAARTAPPRPN-VPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPG 205
              +  L  T E +  +  + P P   P+   PTP  P      P P + P + P   PP 
Sbjct: 4360 FVNCSLSCTLEFYNWSCPSTPSPTPTPSKSTPTPSKPSSTPSKPTPGTKPPECPDFDPPR 4419

Query: 206  -------------PLTKGNLPVVAPPVPCAPPPPP 227
                            K N  V    V C PPP P
Sbjct: 4420 QENETWWLCDCFMATCKYNNTVEIVKVECEPPPMP 4454


>gi|162329583 cleavage and polyadenylation specific factor 6, 68 kD
           subunit [Homo sapiens]
          Length = 551

 Score =  105 bits (261), Expect = 1e-22
 Identities = 91/271 (33%), Positives = 104/271 (38%), Gaps = 63/271 (23%)

Query: 112 AGQRDVAGGKTGQGPGSRAPSP-------RLPNKTISGPLIP-PASPRLGNTSEAHGAAR 163
           +GQ    G     G  SRA  P       R P     G   P PA P  G       A +
Sbjct: 177 SGQMSGEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGP--GGPPPPFPAGQ 234

Query: 164 TAPPRPNVPAPPPPTPPPPPPP---LPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVP 220
           T PPRP +  P PP PP PPPP   LPPPL            PP    +   PV+ P  P
Sbjct: 235 T-PPRPPLGPPGPPGPPGPPPPGQVLPPPL----------AGPPNRGDRPPPPVLFPGQP 283

Query: 221 CAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPA 280
              PP  P PP  PPP+P                   PP PPP    PP         P 
Sbjct: 284 FGQPPLGPLPPGPPPPVPGYGP---------------PPGPPPPQQGPP--------PPP 320

Query: 281 SPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKA 340
            P      PP PP PL P  + +P   LP PP PG       PPP P  +P+F  PP  +
Sbjct: 321 GPF-----PPRPPGPLGPPLTLAPPPHLPGPP-PG------APPPAPHVNPAFFPPPTNS 368

Query: 341 GAQAL----PAPPAPPGSQPFLQKKRHGRPG 367
           G        P P  P G  P   +  +G PG
Sbjct: 369 GMPTSDSRGPPPTDPYGRPPPYDRGDYGPPG 399



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 78/249 (31%), Positives = 83/249 (33%), Gaps = 51/249 (20%)

Query: 141 SGPLIPPASPRLGNTSEAHGAAR---TAPPRPNVPAPPPPTPPPPPPPL--PPPLPSSSP 195
           +GP  P  S R        G  R     P     P P  P  PPPP P    PP P   P
Sbjct: 186 AGP--PGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPAGQTPPRPPLGP 243

Query: 196 IKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPL 255
              P   PPGP          PP    PPP   PP     P PP         +P L PL
Sbjct: 244 PGPP--GPPGP---------PPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPL 292

Query: 256 HLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPG 315
             PP PPP    P  GY G    P  P Q    PP P PP PP     P    P P LPG
Sbjct: 293 --PPGPPP----PVPGY-GPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPG 345

Query: 316 VNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNP 375
                  PPP  P                   PPAP  +  F     +        +  P
Sbjct: 346 -------PPPGAP-------------------PPAPHVNPAFFPPPTNSGMPTSDSRGPP 379

Query: 376 PPAPPARSP 384
           P  P  R P
Sbjct: 380 PTDPYGRPP 388



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 70/214 (32%), Positives = 77/214 (35%), Gaps = 34/214 (15%)

Query: 203 PPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPP 262
           P G   +G  P   P     P P  P  PP  PP P         + P   P   P  PP
Sbjct: 198 PQGGRGRGRFPGAVPGGDRFPGPAGPGGPP--PPFPAGQTPPRPPLGPP-GPPGPPGPPP 254

Query: 263 PLPLLPP--CGYPGLKAEPASPAQDAQEPPAPPP--PLPPYASCSPRASLPAPPLPGVNS 318
           P  +LPP   G P     P  P     +P   PP  PLPP          P PP+PG   
Sbjct: 255 PGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPG---------PPPPVPGYG- 304

Query: 319 SSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPG--SQPFLQKKRHGRPGAGGGKLNPP 376
               PPP PP  P  Q PP   G    P PP PPG    P         PG   G   PP
Sbjct: 305 ----PPPGPP--PPQQGPPPPPG----PFPPRPPGPLGPPLTLAPPPHLPGPPPGA--PP 352

Query: 377 PAP---PARSPTTELSSKSQQATAWTPTQQPGGQ 407
           PAP   PA  P    S      +   P   P G+
Sbjct: 353 PAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGR 386



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 74/261 (28%), Positives = 81/261 (31%), Gaps = 100/261 (38%)

Query: 4   PPPPPPPLP----PPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRL 59
           P  PPPP P    PP PPLG P PP P  PP          A P  R             
Sbjct: 223 PGGPPPPFPAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNR------------- 269

Query: 60  RKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAG 119
                  DR  P +                           LF G     +P GQ  +  
Sbjct: 270 ------GDRPPPPV---------------------------LFPG-----QPFGQPPL-- 289

Query: 120 GKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTP 179
                GP    P P +P     GP  PP  P               PP+   P PP P P
Sbjct: 290 -----GPLPPGPPPPVPG---YGP--PPGPP---------------PPQQGPPPPPGPFP 324

Query: 180 PPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPP-TPPPLP 238
           P PP PL PPL  + P                 P +  P P APPP P   P   PPP  
Sbjct: 325 PRPPGPLGPPLTLAPP-----------------PHLPGPPPGAPPPAPHVNPAFFPPPTN 367

Query: 239 PASVLSDKAVKPQLAPLHLPP 259
                SD    P   P   PP
Sbjct: 368 SGMPTSDSRGPPPTDPYGRPP 388



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 58/212 (27%), Positives = 65/212 (30%), Gaps = 77/212 (36%)

Query: 2   PVPP--PPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSS---LRRADPKGRSALLADIQQG 56
           P PP  PP PP PP PPP G   PPP + PP   D      L    P G+  L       
Sbjct: 237 PRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPL------- 289

Query: 57  TRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRD 116
                   +     P +    G     G     +G   PP       G FP         
Sbjct: 290 ------GPLPPGPPPPV---PGYGPPPGPPPPQQGPPPPP-------GPFP--------- 324

Query: 117 VAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPP 176
                           PR P     GPL PP                T  P P++P PPP
Sbjct: 325 ----------------PRPP-----GPLGPPL---------------TLAPPPHLPGPPP 348

Query: 177 PTPPPPPPP----LPPPLPSSSPIKTPLVSPP 204
             PPP P       PPP  S  P       PP
Sbjct: 349 GAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPP 380



 Score = 36.6 bits (83), Expect = 0.052
 Identities = 23/59 (38%), Positives = 29/59 (49%), Gaps = 16/59 (27%)

Query: 2   PVPPP----PPPPLPPPPPPLGAPP----------PPPPSAPPVSTDTSSLRRADPKGR 46
           P+ PP    PPP LP PPP  GAPP          PPP ++   ++D+      DP GR
Sbjct: 330 PLGPPLTLAPPPHLPGPPP--GAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGR 386


>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score =  103 bits (258), Expect = 3e-22
 Identities = 127/455 (27%), Positives = 173/455 (38%), Gaps = 66/455 (14%)

Query: 1   MPVPP---PPPPPLP---PPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQ 54
           +P PP   PP PPL    PPPPP+ AP PP P++P     T   R   P G +   +D+ 
Sbjct: 208 IPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASP----HTVGTRLFPPGGVTKWKSDVA 263

Query: 55  QGTRLRKVTQINDRSAPQIE--SSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPA 112
              R  + T+ +   +P     S+ G N E   +        PPT   +     PV    
Sbjct: 264 LNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT--PVRTSSIPVQEAQ 321

Query: 113 GQRDVAGGKTGQGPGSRAPSP--------------RLPNKTISGPL--IPPASPRLGNT- 155
                  G T + P SR P P              R P     G L    PASPRLG + 
Sbjct: 322 EAPRKEEGATKKAP-SRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQ 380

Query: 156 SEAHGAARTAPPRPNVPAPPPPTPPPPP--PPLPPPLPSSSPIKTPLVSPPGPLTKGNLP 213
           S+A   A T PP P +P P PP PPP P  PP  PPLP +         PP   TK    
Sbjct: 381 SQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQ----KAAHPPAGFTK-TPK 435

Query: 214 VVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPP-------IPPPLPL 266
             +P +   P PP P    +  P+        + ++ +LA                P P 
Sbjct: 436 SSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPT 495

Query: 267 LPPCGYPGLKAEPASPAQDA-------QEPPAPPPPLPPYASCSPRASLPAPPLPGVNSS 319
           + P    G K  P  P ++          PP  P      +S +   + P+  LP V+  
Sbjct: 496 VAPQSKEGKKG-PRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYI 554

Query: 320 SETPPPLPPKSPSFQAPPQKAGAQALPAPPA----PPGSQPFLQKKRHGRPGAGGGKLNP 375
            +  P    +    +   + + A    A P+    PP  +P L+  R    GA   KL+ 
Sbjct: 555 PQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPP--KPRLEGGRICENGADDDKLSK 612

Query: 376 PPA---PPARS---PTTELSSKSQQATAWTPTQQP 404
           P A   PP  +   PTT L  K+    A  P   P
Sbjct: 613 PVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATP 647



 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 105/334 (31%), Positives = 126/334 (37%), Gaps = 102/334 (30%)

Query: 144 LIPPASPRLGNTSEAHGAART-APPRPNVPAPPPPTPPPPPPPL---PPPLPSSSPIKTP 199
           LIPP  P       A G  +  + P    P P PP+  PPPPPL   PPP PS +P   P
Sbjct: 138 LIPPPPP-----GPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPP 192

Query: 200 LV---SPPGPLTKGNLPV---VAPPVP----CAPPPPPPPPPPTPPPLPPASV------- 242
           ++   SPP  L+  ++P      PP P     APPPPP P P  P P  P +V       
Sbjct: 193 VLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPP 252

Query: 243 ------LSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEP----------------- 279
                  SD A+  + A       PP  P  P     G   EP                 
Sbjct: 253 GGVTKWKSDVALNGRQAEA-TRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVR 311

Query: 280 --ASPAQDAQEPP---------APPP-PLPPYASCSP------------------RASLP 309
             + P Q+AQE P         AP   PLPP     P                  +A+ P
Sbjct: 312 TSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAP 371

Query: 310 APPLPGVNSS-----SETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHG 364
           A P  G + S     + TPPP PP  P   APP        PAPP PP + P    ++  
Sbjct: 372 ASPRLGQSQSQADERAGTPPPAPPLPP--PAPPLPP-----PAPPLPPAAPPLPCAQKAA 424

Query: 365 RPGAGGGK--------LNPPPAPPARSPTTELSS 390
            P AG  K        L P P PP  SP    SS
Sbjct: 425 HPPAGFTKTPKSSSPALKPKPNPP--SPENTASS 456



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 111/414 (26%), Positives = 137/414 (33%), Gaps = 89/414 (21%)

Query: 3   VPPPPPPPLPPPP-----PPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGT 57
           +PPPPP P P PP     PP G+P P PPS  P       L    P   +     +    
Sbjct: 139 IPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAP-PPPPLLLEPPPPPSMAPPPPPV---- 193

Query: 58  RLRKVTQINDRSAPQIESSKGTNKEGGGSANTR------GASTPPTLGDLFAGGFPVLRP 111
            L  ++  +  S+P I +           A          A  PP        G  +  P
Sbjct: 194 -LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPP 252

Query: 112 AG----QRDVA-GGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAP 166
            G    + DVA  G+  Q   +RA  PR P +     L P   P L        + +  P
Sbjct: 253 GGVTKWKSDVALNGR--QAEATRASPPRSPAEPKGSALGPNPEPHL----TFPRSFKVPP 306

Query: 167 PRP----NVPAPPPPTPP----------PPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNL 212
           P P    ++P       P          P   PLPP        +      P P   G L
Sbjct: 307 PTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGEL 366

Query: 213 PVVAPPVP------------CAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPI 260
              AP  P               PPP PP PP  PPLPP             AP  LPP 
Sbjct: 367 KATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP------------AP-PLPPA 413

Query: 261 PPPLPLL-----PPCGY--------PGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRAS 307
            PPLP       PP G+        P LK +P  P+ +     AP     P      R  
Sbjct: 414 APPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNE 473

Query: 308 LPAPPLPGVN------SSSETPPPLPPKSPSFQAP--PQKAGAQALPAPPAPPG 353
           L A  L G        S    P   P      + P  P+K    +LPA   PPG
Sbjct: 474 L-AAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPG 526



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 79/297 (26%), Positives = 97/297 (32%), Gaps = 92/297 (30%)

Query: 179 PPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLP 238
           PPPPP P P P    S        PPG            P+P  P   PPPPP    P P
Sbjct: 140 PPPPPGPAPGPPQDIS-------EPPG----------GSPLPSPPSTAPPPPPLLLEPPP 182

Query: 239 PASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPP----- 293
           P S+                  PPP P+L     P   + P+ P      PPAPP     
Sbjct: 183 PPSMA-----------------PPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLA 225

Query: 294 PPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSF------QAPPQKAGAQALPA 347
           PP PP  + +P    PAP  P    +   PP    K  S       QA   +A     PA
Sbjct: 226 PPPPPVPAPAP----PAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPA 281

Query: 348 PPAP----PGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP-----TTELSSKSQQATAW 398
            P      P  +P L   R  +         PPP P   S        E   K + AT  
Sbjct: 282 EPKGSALGPNPEPHLTFPRSFKV--------PPPTPVRTSSIPVQEAQEAPRKEEGATKK 333

Query: 399 TPTQQPGGQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRTPG 455
            P++ P                           PP    +P  ++YP + P    PG
Sbjct: 334 APSRLP--------------------------LPPSFHIRPASQVYPDRAPEPDCPG 364



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 112/440 (25%), Positives = 144/440 (32%), Gaps = 74/440 (16%)

Query: 5   PPPPPPLPPPPPPLGAPPPP-PPSAPPVSTDTSSLR-----RADPKGRSALLADIQQGTR 58
           PPP PPLPPP PPL  P PP PP+APP+     +          PK  S  L        
Sbjct: 390 PPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKP------ 443

Query: 59  LRKVTQINDRSAPQIESSKGTN-KEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDV 117
                + N  S     SS   + ++       R        G      F   RP G    
Sbjct: 444 -----KPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRP-GPTVA 497

Query: 118 AGGKTGQGPGSRAPSPRLPNK----TISGPLIPPASPR--LGNTSEAHGAARTAPPRPNV 171
              K G+        PRLP K    ++     PP  P   LG +S     A  +   P+V
Sbjct: 498 PQSKEGK------KGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSV 551

Query: 172 PAPPPPTPPPPPPPLPPPLP---SSSPIKTPLVS----PPGP-LTKGNLPVVAPPVPCAP 223
              P  +P P    +   L    SS+  K    S    PP P L  G +           
Sbjct: 552 DYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLS 611

Query: 224 PPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPA 283
            P     PP    L P + L  KA+                P +PP   P    EPA P 
Sbjct: 612 KPVAKNLPPQSTTLLPTTSLQPKAMLG--------------PAIPPKATP----EPAIPP 653

Query: 284 QDAQEPPAPP-----PPLPPYASCSPRASLPAPPLPGVNSSSETPPP-----LPPKSPSF 333
           +    P  PP     P  P  A+  P   L A   P + S++ T P      +  K    
Sbjct: 654 KATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGP 713

Query: 334 QAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPA-------RSPTT 386
              P+K  +Q +  P    G     +  R    GA      PP   P          P  
Sbjct: 714 AGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHC 773

Query: 387 ELSSKSQQATAWTPTQQPGG 406
             SS S++     PT   GG
Sbjct: 774 HQSSLSREVAVVMPTLARGG 793



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 122/507 (24%), Positives = 158/507 (31%), Gaps = 119/507 (23%)

Query: 2   PVPPPPPPPLPPPPPPLGAPPPPPPSA--------------------------PPVSTDT 35
           P  PPP PPLPPP PPL    PP P A                          PP   +T
Sbjct: 394 PPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENT 453

Query: 36  SSLRRADPKGRSAL------LADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANT 89
           +S    D +  S +      LA    G+R R+   ++ R  P +       K+G      
Sbjct: 454 ASSAPVDWRDPSQMEKLRNELAAYLCGSR-REDRFLSHRPGPTVAPQSKEGKKGPRLPEK 512

Query: 90  R------GASTPPTLGDLFAGGF-------------------------PVLRP------A 112
                     TPP + +   GG                          P +R       A
Sbjct: 513 ETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEA 572

Query: 113 GQRDVAGGKTGQGPGSRAPSPRLPNKTI----------SGPL---IPPASPRLGNTSEAH 159
                A  +     GS  P PRL    I          S P+   +PP S  L  T+   
Sbjct: 573 RLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQ 632

Query: 160 GAARTAPPRPNVPAPPPPTPP--------PPPPPLPP--PLPSSSPIKTPLVSPPGPL-- 207
             A   P  P    P P  PP        PP   L P  PL ++S   TPL +  GP   
Sbjct: 633 PKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIA 692

Query: 208 -TKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPL 266
            T   LP     +       P   P  P         S +   P  A       P     
Sbjct: 693 STATTLPTTTSQLMAEKDSGPAGQPEKPA--------SQEVSTPSQA--RGEGSPSEATR 742

Query: 267 LPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPL-------PGVNSS 319
           LP  G     A P   +    E P    P    +S S   ++  P L       PG    
Sbjct: 743 LPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVE 802

Query: 320 SETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFL-----QKKRHGRP-GAGGGKL 373
            + PP LP K P+   P  +     +       GS   L     Q+ + GR  GA  G+ 
Sbjct: 803 VKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRS 862

Query: 374 NPPPAPPARSPTTELSSKSQQATAWTP 400
           + P +    S   E SS S   +  TP
Sbjct: 863 SLPGSLRDHSHQAEASSDSIFHSQGTP 889



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 68/270 (25%), Positives = 90/270 (33%), Gaps = 39/270 (14%)

Query: 2    PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRK 61
            PV    PP LP  PP   A P       PV+ +   + R  P   + LLA  Q+  + R 
Sbjct: 800  PVEVKEPPGLPAKPPA-SAQPTDELLRHPVTGEV--VERGSPM--ALLLAARQRAQKGRS 854

Query: 62   VTQINDRSA-PQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGG 120
            V     RS+ P          E    +      TP +   +     P L    ++D    
Sbjct: 855  VGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVV-----PKLPKEAEKD---- 905

Query: 121  KTGQGPGSRAP-SPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTP 179
                     +P +  +PNK           PRLG  +E    +R    R N   P P  P
Sbjct: 906  ---------SPLTTEIPNKW---------GPRLGRDAEGTELSR----RHNWTKPEPQAP 943

Query: 180  PPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPP 239
                   P  LP   P+     SPP P  K             PPPP     P  PP P 
Sbjct: 944  VAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDP-EPPAPA 1002

Query: 240  ASVLSDKAVKPQLAPLHLPPIPPPLPLLPP 269
               L  ++  P+     L  +P   P  PP
Sbjct: 1003 LQYLGRQSSPPRNNYSDLRQLPNAGPGAPP 1032



 Score = 29.6 bits (65), Expect = 6.4
 Identities = 32/115 (27%), Positives = 41/115 (35%), Gaps = 17/115 (14%)

Query: 276  KAEPASPAQDAQEPPAPPP---PLPPYASCSPRASLPA------------PPLPGVNSSS 320
            K EP +P    +  P+  P   PLP   S  P  S               PP P  ++  
Sbjct: 937  KPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDP 996

Query: 321  ETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRH--GRPGAGGGKL 373
            E P P         +PP+   +     P A PG+ P L   R   G   AG G L
Sbjct: 997  EPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGL 1051


>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score =  103 bits (258), Expect = 3e-22
 Identities = 127/455 (27%), Positives = 173/455 (38%), Gaps = 66/455 (14%)

Query: 1   MPVPP---PPPPPLP---PPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQ 54
           +P PP   PP PPL    PPPPP+ AP PP P++P     T   R   P G +   +D+ 
Sbjct: 208 IPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASP----HTVGTRLFPPGGVTKWKSDVA 263

Query: 55  QGTRLRKVTQINDRSAPQIE--SSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPA 112
              R  + T+ +   +P     S+ G N E   +        PPT   +     PV    
Sbjct: 264 LNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT--PVRTSSIPVQEAQ 321

Query: 113 GQRDVAGGKTGQGPGSRAPSP--------------RLPNKTISGPL--IPPASPRLGNT- 155
                  G T + P SR P P              R P     G L    PASPRLG + 
Sbjct: 322 EAPRKEEGATKKAP-SRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQ 380

Query: 156 SEAHGAARTAPPRPNVPAPPPPTPPPPP--PPLPPPLPSSSPIKTPLVSPPGPLTKGNLP 213
           S+A   A T PP P +P P PP PPP P  PP  PPLP +         PP   TK    
Sbjct: 381 SQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQ----KAAHPPAGFTK-TPK 435

Query: 214 VVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPP-------IPPPLPL 266
             +P +   P PP P    +  P+        + ++ +LA                P P 
Sbjct: 436 SSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPT 495

Query: 267 LPPCGYPGLKAEPASPAQDA-------QEPPAPPPPLPPYASCSPRASLPAPPLPGVNSS 319
           + P    G K  P  P ++          PP  P      +S +   + P+  LP V+  
Sbjct: 496 VAPQSKEGKKG-PRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYI 554

Query: 320 SETPPPLPPKSPSFQAPPQKAGAQALPAPPA----PPGSQPFLQKKRHGRPGAGGGKLNP 375
            +  P    +    +   + + A    A P+    PP  +P L+  R    GA   KL+ 
Sbjct: 555 PQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPP--KPRLEGGRICENGADDDKLSK 612

Query: 376 PPA---PPARS---PTTELSSKSQQATAWTPTQQP 404
           P A   PP  +   PTT L  K+    A  P   P
Sbjct: 613 PVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATP 647



 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 105/334 (31%), Positives = 126/334 (37%), Gaps = 102/334 (30%)

Query: 144 LIPPASPRLGNTSEAHGAART-APPRPNVPAPPPPTPPPPPPPL---PPPLPSSSPIKTP 199
           LIPP  P       A G  +  + P    P P PP+  PPPPPL   PPP PS +P   P
Sbjct: 138 LIPPPPP-----GPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPP 192

Query: 200 LV---SPPGPLTKGNLPV---VAPPVP----CAPPPPPPPPPPTPPPLPPASV------- 242
           ++   SPP  L+  ++P      PP P     APPPPP P P  P P  P +V       
Sbjct: 193 VLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPP 252

Query: 243 ------LSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEP----------------- 279
                  SD A+  + A       PP  P  P     G   EP                 
Sbjct: 253 GGVTKWKSDVALNGRQAEA-TRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVR 311

Query: 280 --ASPAQDAQEPP---------APPP-PLPPYASCSP------------------RASLP 309
             + P Q+AQE P         AP   PLPP     P                  +A+ P
Sbjct: 312 TSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAP 371

Query: 310 APPLPGVNSS-----SETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHG 364
           A P  G + S     + TPPP PP  P   APP        PAPP PP + P    ++  
Sbjct: 372 ASPRLGQSQSQADERAGTPPPAPPLPP--PAPPLPP-----PAPPLPPAAPPLPCAQKAA 424

Query: 365 RPGAGGGK--------LNPPPAPPARSPTTELSS 390
            P AG  K        L P P PP  SP    SS
Sbjct: 425 HPPAGFTKTPKSSSPALKPKPNPP--SPENTASS 456



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 111/414 (26%), Positives = 137/414 (33%), Gaps = 89/414 (21%)

Query: 3   VPPPPPPPLPPPP-----PPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGT 57
           +PPPPP P P PP     PP G+P P PPS  P       L    P   +     +    
Sbjct: 139 IPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAP-PPPPLLLEPPPPPSMAPPPPPV---- 193

Query: 58  RLRKVTQINDRSAPQIESSKGTNKEGGGSANTR------GASTPPTLGDLFAGGFPVLRP 111
            L  ++  +  S+P I +           A          A  PP        G  +  P
Sbjct: 194 -LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPP 252

Query: 112 AG----QRDVA-GGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAP 166
            G    + DVA  G+  Q   +RA  PR P +     L P   P L        + +  P
Sbjct: 253 GGVTKWKSDVALNGR--QAEATRASPPRSPAEPKGSALGPNPEPHL----TFPRSFKVPP 306

Query: 167 PRP----NVPAPPPPTPP----------PPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNL 212
           P P    ++P       P          P   PLPP        +      P P   G L
Sbjct: 307 PTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGEL 366

Query: 213 PVVAPPVP------------CAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPI 260
              AP  P               PPP PP PP  PPLPP             AP  LPP 
Sbjct: 367 KATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP------------AP-PLPPA 413

Query: 261 PPPLPLL-----PPCGY--------PGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRAS 307
            PPLP       PP G+        P LK +P  P+ +     AP     P      R  
Sbjct: 414 APPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNE 473

Query: 308 LPAPPLPGVN------SSSETPPPLPPKSPSFQAP--PQKAGAQALPAPPAPPG 353
           L A  L G        S    P   P      + P  P+K    +LPA   PPG
Sbjct: 474 L-AAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPG 526



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 79/297 (26%), Positives = 97/297 (32%), Gaps = 92/297 (30%)

Query: 179 PPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLP 238
           PPPPP P P P    S        PPG            P+P  P   PPPPP    P P
Sbjct: 140 PPPPPGPAPGPPQDIS-------EPPG----------GSPLPSPPSTAPPPPPLLLEPPP 182

Query: 239 PASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPP----- 293
           P S+                  PPP P+L     P   + P+ P      PPAPP     
Sbjct: 183 PPSMA-----------------PPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLA 225

Query: 294 PPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSF------QAPPQKAGAQALPA 347
           PP PP  + +P    PAP  P    +   PP    K  S       QA   +A     PA
Sbjct: 226 PPPPPVPAPAP----PAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPA 281

Query: 348 PPAP----PGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP-----TTELSSKSQQATAW 398
            P      P  +P L   R  +         PPP P   S        E   K + AT  
Sbjct: 282 EPKGSALGPNPEPHLTFPRSFKV--------PPPTPVRTSSIPVQEAQEAPRKEEGATKK 333

Query: 399 TPTQQPGGQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRTPG 455
            P++ P                           PP    +P  ++YP + P    PG
Sbjct: 334 APSRLP--------------------------LPPSFHIRPASQVYPDRAPEPDCPG 364



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 112/440 (25%), Positives = 144/440 (32%), Gaps = 74/440 (16%)

Query: 5   PPPPPPLPPPPPPLGAPPPP-PPSAPPVSTDTSSLR-----RADPKGRSALLADIQQGTR 58
           PPP PPLPPP PPL  P PP PP+APP+     +          PK  S  L        
Sbjct: 390 PPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKP------ 443

Query: 59  LRKVTQINDRSAPQIESSKGTN-KEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDV 117
                + N  S     SS   + ++       R        G      F   RP G    
Sbjct: 444 -----KPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRP-GPTVA 497

Query: 118 AGGKTGQGPGSRAPSPRLPNK----TISGPLIPPASPR--LGNTSEAHGAARTAPPRPNV 171
              K G+        PRLP K    ++     PP  P   LG +S     A  +   P+V
Sbjct: 498 PQSKEGK------KGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSV 551

Query: 172 PAPPPPTPPPPPPPLPPPLP---SSSPIKTPLVS----PPGP-LTKGNLPVVAPPVPCAP 223
              P  +P P    +   L    SS+  K    S    PP P L  G +           
Sbjct: 552 DYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLS 611

Query: 224 PPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPA 283
            P     PP    L P + L  KA+                P +PP   P    EPA P 
Sbjct: 612 KPVAKNLPPQSTTLLPTTSLQPKAMLG--------------PAIPPKATP----EPAIPP 653

Query: 284 QDAQEPPAPP-----PPLPPYASCSPRASLPAPPLPGVNSSSETPPP-----LPPKSPSF 333
           +    P  PP     P  P  A+  P   L A   P + S++ T P      +  K    
Sbjct: 654 KATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGP 713

Query: 334 QAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPA-------RSPTT 386
              P+K  +Q +  P    G     +  R    GA      PP   P          P  
Sbjct: 714 AGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHC 773

Query: 387 ELSSKSQQATAWTPTQQPGG 406
             SS S++     PT   GG
Sbjct: 774 HQSSLSREVAVVMPTLARGG 793



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 122/507 (24%), Positives = 158/507 (31%), Gaps = 119/507 (23%)

Query: 2   PVPPPPPPPLPPPPPPLGAPPPPPPSA--------------------------PPVSTDT 35
           P  PPP PPLPPP PPL    PP P A                          PP   +T
Sbjct: 394 PPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENT 453

Query: 36  SSLRRADPKGRSAL------LADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANT 89
           +S    D +  S +      LA    G+R R+   ++ R  P +       K+G      
Sbjct: 454 ASSAPVDWRDPSQMEKLRNELAAYLCGSR-REDRFLSHRPGPTVAPQSKEGKKGPRLPEK 512

Query: 90  R------GASTPPTLGDLFAGGF-------------------------PVLRP------A 112
                     TPP + +   GG                          P +R       A
Sbjct: 513 ETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEA 572

Query: 113 GQRDVAGGKTGQGPGSRAPSPRLPNKTI----------SGPL---IPPASPRLGNTSEAH 159
                A  +     GS  P PRL    I          S P+   +PP S  L  T+   
Sbjct: 573 RLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQ 632

Query: 160 GAARTAPPRPNVPAPPPPTPP--------PPPPPLPP--PLPSSSPIKTPLVSPPGPL-- 207
             A   P  P    P P  PP        PP   L P  PL ++S   TPL +  GP   
Sbjct: 633 PKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIA 692

Query: 208 -TKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPL 266
            T   LP     +       P   P  P         S +   P  A       P     
Sbjct: 693 STATTLPTTTSQLMAEKDSGPAGQPEKPA--------SQEVSTPSQA--RGEGSPSEATR 742

Query: 267 LPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPL-------PGVNSS 319
           LP  G     A P   +    E P    P    +S S   ++  P L       PG    
Sbjct: 743 LPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVE 802

Query: 320 SETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFL-----QKKRHGRP-GAGGGKL 373
            + PP LP K P+   P  +     +       GS   L     Q+ + GR  GA  G+ 
Sbjct: 803 VKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRS 862

Query: 374 NPPPAPPARSPTTELSSKSQQATAWTP 400
           + P +    S   E SS S   +  TP
Sbjct: 863 SLPGSLRDHSHQAEASSDSIFHSQGTP 889



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 68/270 (25%), Positives = 90/270 (33%), Gaps = 39/270 (14%)

Query: 2    PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRK 61
            PV    PP LP  PP   A P       PV+ +   + R  P   + LLA  Q+  + R 
Sbjct: 800  PVEVKEPPGLPAKPPA-SAQPTDELLRHPVTGEV--VERGSPM--ALLLAARQRAQKGRS 854

Query: 62   VTQINDRSA-PQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGG 120
            V     RS+ P          E    +      TP +   +     P L    ++D    
Sbjct: 855  VGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVV-----PKLPKEAEKD---- 905

Query: 121  KTGQGPGSRAP-SPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTP 179
                     +P +  +PNK           PRLG  +E    +R    R N   P P  P
Sbjct: 906  ---------SPLTTEIPNKW---------GPRLGRDAEGTELSR----RHNWTKPEPQAP 943

Query: 180  PPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPP 239
                   P  LP   P+     SPP P  K             PPPP     P  PP P 
Sbjct: 944  VAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDP-EPPAPA 1002

Query: 240  ASVLSDKAVKPQLAPLHLPPIPPPLPLLPP 269
               L  ++  P+     L  +P   P  PP
Sbjct: 1003 LQYLGRQSSPPRNNYSDLRQLPNAGPGAPP 1032



 Score = 29.6 bits (65), Expect = 6.4
 Identities = 32/115 (27%), Positives = 41/115 (35%), Gaps = 17/115 (14%)

Query: 276  KAEPASPAQDAQEPPAPPP---PLPPYASCSPRASLPA------------PPLPGVNSSS 320
            K EP +P    +  P+  P   PLP   S  P  S               PP P  ++  
Sbjct: 937  KPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDP 996

Query: 321  ETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRH--GRPGAGGGKL 373
            E P P         +PP+   +     P A PG+ P L   R   G   AG G L
Sbjct: 997  EPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGL 1051


>gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo
           sapiens]
          Length = 1188

 Score =  103 bits (258), Expect = 3e-22
 Identities = 127/455 (27%), Positives = 173/455 (38%), Gaps = 66/455 (14%)

Query: 1   MPVPP---PPPPPLP---PPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQ 54
           +P PP   PP PPL    PPPPP+ AP PP P++P     T   R   P G +   +D+ 
Sbjct: 208 IPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASP----HTVGTRLFPPGGVTKWKSDVA 263

Query: 55  QGTRLRKVTQINDRSAPQIE--SSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPA 112
              R  + T+ +   +P     S+ G N E   +        PPT   +     PV    
Sbjct: 264 LNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT--PVRTSSIPVQEAQ 321

Query: 113 GQRDVAGGKTGQGPGSRAPSP--------------RLPNKTISGPL--IPPASPRLGNT- 155
                  G T + P SR P P              R P     G L    PASPRLG + 
Sbjct: 322 EAPRKEEGATKKAP-SRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQ 380

Query: 156 SEAHGAARTAPPRPNVPAPPPPTPPPPP--PPLPPPLPSSSPIKTPLVSPPGPLTKGNLP 213
           S+A   A T PP P +P P PP PPP P  PP  PPLP +         PP   TK    
Sbjct: 381 SQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQ----KAAHPPAGFTK-TPK 435

Query: 214 VVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPP-------IPPPLPL 266
             +P +   P PP P    +  P+        + ++ +LA                P P 
Sbjct: 436 SSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPT 495

Query: 267 LPPCGYPGLKAEPASPAQDA-------QEPPAPPPPLPPYASCSPRASLPAPPLPGVNSS 319
           + P    G K  P  P ++          PP  P      +S +   + P+  LP V+  
Sbjct: 496 VAPQSKEGKKG-PRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYI 554

Query: 320 SETPPPLPPKSPSFQAPPQKAGAQALPAPPA----PPGSQPFLQKKRHGRPGAGGGKLNP 375
            +  P    +    +   + + A    A P+    PP  +P L+  R    GA   KL+ 
Sbjct: 555 PQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPP--KPRLEGGRICENGADDDKLSK 612

Query: 376 PPA---PPARS---PTTELSSKSQQATAWTPTQQP 404
           P A   PP  +   PTT L  K+    A  P   P
Sbjct: 613 PVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATP 647



 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 105/334 (31%), Positives = 126/334 (37%), Gaps = 102/334 (30%)

Query: 144 LIPPASPRLGNTSEAHGAART-APPRPNVPAPPPPTPPPPPPPL---PPPLPSSSPIKTP 199
           LIPP  P       A G  +  + P    P P PP+  PPPPPL   PPP PS +P   P
Sbjct: 138 LIPPPPP-----GPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPP 192

Query: 200 LV---SPPGPLTKGNLPV---VAPPVP----CAPPPPPPPPPPTPPPLPPASV------- 242
           ++   SPP  L+  ++P      PP P     APPPPP P P  P P  P +V       
Sbjct: 193 VLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPP 252

Query: 243 ------LSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEP----------------- 279
                  SD A+  + A       PP  P  P     G   EP                 
Sbjct: 253 GGVTKWKSDVALNGRQAEA-TRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVR 311

Query: 280 --ASPAQDAQEPP---------APPP-PLPPYASCSP------------------RASLP 309
             + P Q+AQE P         AP   PLPP     P                  +A+ P
Sbjct: 312 TSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAP 371

Query: 310 APPLPGVNSS-----SETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHG 364
           A P  G + S     + TPPP PP  P   APP        PAPP PP + P    ++  
Sbjct: 372 ASPRLGQSQSQADERAGTPPPAPPLPP--PAPPLPP-----PAPPLPPAAPPLPCAQKAA 424

Query: 365 RPGAGGGK--------LNPPPAPPARSPTTELSS 390
            P AG  K        L P P PP  SP    SS
Sbjct: 425 HPPAGFTKTPKSSSPALKPKPNPP--SPENTASS 456



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 111/414 (26%), Positives = 137/414 (33%), Gaps = 89/414 (21%)

Query: 3   VPPPPPPPLPPPP-----PPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGT 57
           +PPPPP P P PP     PP G+P P PPS  P       L    P   +     +    
Sbjct: 139 IPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAP-PPPPLLLEPPPPPSMAPPPPPV---- 193

Query: 58  RLRKVTQINDRSAPQIESSKGTNKEGGGSANTR------GASTPPTLGDLFAGGFPVLRP 111
            L  ++  +  S+P I +           A          A  PP        G  +  P
Sbjct: 194 -LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPP 252

Query: 112 AG----QRDVA-GGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAP 166
            G    + DVA  G+  Q   +RA  PR P +     L P   P L        + +  P
Sbjct: 253 GGVTKWKSDVALNGR--QAEATRASPPRSPAEPKGSALGPNPEPHL----TFPRSFKVPP 306

Query: 167 PRP----NVPAPPPPTPP----------PPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNL 212
           P P    ++P       P          P   PLPP        +      P P   G L
Sbjct: 307 PTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGEL 366

Query: 213 PVVAPPVP------------CAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPI 260
              AP  P               PPP PP PP  PPLPP             AP  LPP 
Sbjct: 367 KATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP------------AP-PLPPA 413

Query: 261 PPPLPLL-----PPCGY--------PGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRAS 307
            PPLP       PP G+        P LK +P  P+ +     AP     P      R  
Sbjct: 414 APPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNE 473

Query: 308 LPAPPLPGVN------SSSETPPPLPPKSPSFQAP--PQKAGAQALPAPPAPPG 353
           L A  L G        S    P   P      + P  P+K    +LPA   PPG
Sbjct: 474 L-AAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPG 526



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 79/297 (26%), Positives = 97/297 (32%), Gaps = 92/297 (30%)

Query: 179 PPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLP 238
           PPPPP P P P    S        PPG            P+P  P   PPPPP    P P
Sbjct: 140 PPPPPGPAPGPPQDIS-------EPPG----------GSPLPSPPSTAPPPPPLLLEPPP 182

Query: 239 PASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPP----- 293
           P S+                  PPP P+L     P   + P+ P      PPAPP     
Sbjct: 183 PPSMA-----------------PPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLA 225

Query: 294 PPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSF------QAPPQKAGAQALPA 347
           PP PP  + +P    PAP  P    +   PP    K  S       QA   +A     PA
Sbjct: 226 PPPPPVPAPAP----PAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPA 281

Query: 348 PPAP----PGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP-----TTELSSKSQQATAW 398
            P      P  +P L   R  +         PPP P   S        E   K + AT  
Sbjct: 282 EPKGSALGPNPEPHLTFPRSFKV--------PPPTPVRTSSIPVQEAQEAPRKEEGATKK 333

Query: 399 TPTQQPGGQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRTPG 455
            P++ P                           PP    +P  ++YP + P    PG
Sbjct: 334 APSRLP--------------------------LPPSFHIRPASQVYPDRAPEPDCPG 364



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 112/440 (25%), Positives = 144/440 (32%), Gaps = 74/440 (16%)

Query: 5   PPPPPPLPPPPPPLGAPPPP-PPSAPPVSTDTSSLR-----RADPKGRSALLADIQQGTR 58
           PPP PPLPPP PPL  P PP PP+APP+     +          PK  S  L        
Sbjct: 390 PPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKP------ 443

Query: 59  LRKVTQINDRSAPQIESSKGTN-KEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDV 117
                + N  S     SS   + ++       R        G      F   RP G    
Sbjct: 444 -----KPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRP-GPTVA 497

Query: 118 AGGKTGQGPGSRAPSPRLPNK----TISGPLIPPASPR--LGNTSEAHGAARTAPPRPNV 171
              K G+        PRLP K    ++     PP  P   LG +S     A  +   P+V
Sbjct: 498 PQSKEGK------KGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSV 551

Query: 172 PAPPPPTPPPPPPPLPPPLP---SSSPIKTPLVS----PPGP-LTKGNLPVVAPPVPCAP 223
              P  +P P    +   L    SS+  K    S    PP P L  G +           
Sbjct: 552 DYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLS 611

Query: 224 PPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPA 283
            P     PP    L P + L  KA+                P +PP   P    EPA P 
Sbjct: 612 KPVAKNLPPQSTTLLPTTSLQPKAMLG--------------PAIPPKATP----EPAIPP 653

Query: 284 QDAQEPPAPP-----PPLPPYASCSPRASLPAPPLPGVNSSSETPPP-----LPPKSPSF 333
           +    P  PP     P  P  A+  P   L A   P + S++ T P      +  K    
Sbjct: 654 KATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGP 713

Query: 334 QAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPA-------RSPTT 386
              P+K  +Q +  P    G     +  R    GA      PP   P          P  
Sbjct: 714 AGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHC 773

Query: 387 ELSSKSQQATAWTPTQQPGG 406
             SS S++     PT   GG
Sbjct: 774 HQSSLSREVAVVMPTLARGG 793



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 122/507 (24%), Positives = 158/507 (31%), Gaps = 119/507 (23%)

Query: 2   PVPPPPPPPLPPPPPPLGAPPPPPPSA--------------------------PPVSTDT 35
           P  PPP PPLPPP PPL    PP P A                          PP   +T
Sbjct: 394 PPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENT 453

Query: 36  SSLRRADPKGRSAL------LADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANT 89
           +S    D +  S +      LA    G+R R+   ++ R  P +       K+G      
Sbjct: 454 ASSAPVDWRDPSQMEKLRNELAAYLCGSR-REDRFLSHRPGPTVAPQSKEGKKGPRLPEK 512

Query: 90  R------GASTPPTLGDLFAGGF-------------------------PVLRP------A 112
                     TPP + +   GG                          P +R       A
Sbjct: 513 ETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEA 572

Query: 113 GQRDVAGGKTGQGPGSRAPSPRLPNKTI----------SGPL---IPPASPRLGNTSEAH 159
                A  +     GS  P PRL    I          S P+   +PP S  L  T+   
Sbjct: 573 RLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQ 632

Query: 160 GAARTAPPRPNVPAPPPPTPP--------PPPPPLPP--PLPSSSPIKTPLVSPPGPL-- 207
             A   P  P    P P  PP        PP   L P  PL ++S   TPL +  GP   
Sbjct: 633 PKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIA 692

Query: 208 -TKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPL 266
            T   LP     +       P   P  P         S +   P  A       P     
Sbjct: 693 STATTLPTTTSQLMAEKDSGPAGQPEKPA--------SQEVSTPSQA--RGEGSPSEATR 742

Query: 267 LPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPL-------PGVNSS 319
           LP  G     A P   +    E P    P    +S S   ++  P L       PG    
Sbjct: 743 LPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVE 802

Query: 320 SETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFL-----QKKRHGRP-GAGGGKL 373
            + PP LP K P+   P  +     +       GS   L     Q+ + GR  GA  G+ 
Sbjct: 803 VKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRS 862

Query: 374 NPPPAPPARSPTTELSSKSQQATAWTP 400
           + P +    S   E SS S   +  TP
Sbjct: 863 SLPGSLRDHSHQAEASSDSIFHSQGTP 889



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 68/270 (25%), Positives = 90/270 (33%), Gaps = 39/270 (14%)

Query: 2    PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRK 61
            PV    PP LP  PP   A P       PV+ +   + R  P   + LLA  Q+  + R 
Sbjct: 800  PVEVKEPPGLPAKPPA-SAQPTDELLRHPVTGEV--VERGSPM--ALLLAARQRAQKGRS 854

Query: 62   VTQINDRSA-PQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGG 120
            V     RS+ P          E    +      TP +   +     P L    ++D    
Sbjct: 855  VGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVV-----PKLPKEAEKD---- 905

Query: 121  KTGQGPGSRAP-SPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTP 179
                     +P +  +PNK           PRLG  +E    +R    R N   P P  P
Sbjct: 906  ---------SPLTTEIPNKW---------GPRLGRDAEGTELSR----RHNWTKPEPQAP 943

Query: 180  PPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPP 239
                   P  LP   P+     SPP P  K             PPPP     P  PP P 
Sbjct: 944  VAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDP-EPPAPA 1002

Query: 240  ASVLSDKAVKPQLAPLHLPPIPPPLPLLPP 269
               L  ++  P+     L  +P   P  PP
Sbjct: 1003 LQYLGRQSSPPRNNYSDLRQLPNAGPGAPP 1032



 Score = 29.6 bits (65), Expect = 6.4
 Identities = 32/115 (27%), Positives = 41/115 (35%), Gaps = 17/115 (14%)

Query: 276  KAEPASPAQDAQEPPAPPP---PLPPYASCSPRASLPA------------PPLPGVNSSS 320
            K EP +P    +  P+  P   PLP   S  P  S               PP P  ++  
Sbjct: 937  KPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDP 996

Query: 321  ETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRH--GRPGAGGGKL 373
            E P P         +PP+   +     P A PG+ P L   R   G   AG G L
Sbjct: 997  EPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGL 1051


>gi|150417989 cyclin K isoform 1 [Homo sapiens]
          Length = 580

 Score =  103 bits (257), Expect = 3e-22
 Identities = 90/300 (30%), Positives = 113/300 (37%), Gaps = 65/300 (21%)

Query: 110 RPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPR- 168
           +PA Q+  A     Q P   +P P  P +     ++ P         E + AA   PP+ 
Sbjct: 309 QPAQQQQPA-----QQPKKPSPQPSSPRQVKRAVVVSP--------KEENKAAEPPPPKI 355

Query: 169 PNVPAPPPPTPPP-PPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPP-- 225
           P +    PP PP  PPP   PPL ++         PPGP+   +LP V  P P  P P  
Sbjct: 356 PKIETTHPPLPPAHPPPDRKPPLAAA----LGEAEPPGPVDATDLPKVQIPPPAHPAPVH 411

Query: 226 PPPPPPPTPPPLPPASVLSDKAVKPQL----------------APLH--LPPI---PPPL 264
            PPP P  PPP PP+S ++  +                      P +  LPP    P  L
Sbjct: 412 QPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHL 471

Query: 265 PLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPP 324
           P  P    P     P  P   +  PPA PPP P Y    P  +   PP P     +   P
Sbjct: 472 PYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVP 531

Query: 325 PLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP 384
           P PP  P    PP      + P P  PPG QP +                PPP PP   P
Sbjct: 532 PHPP--PGLGLPP-----ASYPPPAVPPGGQPPV----------------PPPIPPPGMP 568



 Score = 95.5 bits (236), Expect = 9e-20
 Identities = 97/353 (27%), Positives = 121/353 (34%), Gaps = 103/353 (29%)

Query: 1   MPVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLR 60
           MP   P     PP   P    P    S P  S++ S  ++ DP          QQ  + +
Sbjct: 265 MPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDP----------QQPAQQQ 314

Query: 61  KVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGG 120
           +  Q   + +PQ  S +                                    +R V   
Sbjct: 315 QPAQQPKKPSPQPSSPRQV----------------------------------KRAVVVS 340

Query: 121 KTGQGPGSRAPSPRLPNKTISGPLIPPASP----------RLGNTSEAHGAARTAPPRPN 170
              +   +  P P++P    + P +PPA P           LG          T  P+  
Sbjct: 341 PKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQ 400

Query: 171 VPAPPPPTPPPPPPPL----PPPLPSS---------------------SPIKT------- 198
           +P P  P P   PPPL    PPP PSS                     S +KT       
Sbjct: 401 IPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGA 460

Query: 199 --PLVSPPGPLTKGNLPVVAPPVPCAPPPPPPP--------PPPTP--PPLPPASVLSDK 246
             P   PP  L     P V PP P  PP PPPP        PPPTP  PP PP    +  
Sbjct: 461 LPPAYGPPAHLPYH--PHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFP 518

Query: 247 AVKPQLAPLH-LPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPP 298
              P+L P H +PP PPP   LPP  YP     P    Q    PP PPP +PP
Sbjct: 519 PPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPG--GQPPVPPPIPPPGMPP 569



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 45/161 (27%), Positives = 57/161 (35%), Gaps = 27/161 (16%)

Query: 255 LHLPPIPPPLPLLPPC--GYPGLKAEPASPAQ-DAQEP-----PAPPPPLPPYASCSPRA 306
           L  PP   P P +P      P   +EP+ P Q D Q+P     PA  P  P     SPR 
Sbjct: 273 LQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQ 332

Query: 307 SLPAPPLPGVNSSSETPPPLPPKSPSFQA--PPQKAGAQALPAPPAPPGSQPFLQKKRHG 364
              A  +     +    PP PPK P  +   PP       LP    PP  +P L      
Sbjct: 333 VKRAVVVSPKEENKAAEPP-PPKIPKIETTHPP-------LPPAHPPPDRKPPL------ 378

Query: 365 RPGAGGGKLNPP-PAPPARSPTTELSSKSQQATAWTPTQQP 404
              A  G+  PP P      P  ++   +  A    P   P
Sbjct: 379 --AAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLP 417



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 24/47 (51%), Positives = 24/47 (51%), Gaps = 8/47 (17%)

Query: 3   VPPPPPPP--LPP---PP---PPLGAPPPPPPSAPPVSTDTSSLRRA 41
           VPP PPP   LPP   PP   PP G PP PPP  PP       L RA
Sbjct: 530 VPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRA 576



 Score = 32.3 bits (72), Expect = 0.99
 Identities = 32/127 (25%), Positives = 44/127 (34%), Gaps = 18/127 (14%)

Query: 294 PPLPPYASCSPRASLPAPPLPGVNSS--SETPPPLPPKSPSFQAPPQKAGAQALPAPPAP 351
           P   P+    P +  P P +P V  S  S++  P  P+    Q P Q+      P  P+P
Sbjct: 266 PHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSP 325

Query: 352 PGSQP-------FLQKKRHGR------PGAGGGKLNPPPAPPARSPTTELSSKSQQATAW 398
             S P        +  K   +      P     +   PP PPA  P      K   A A 
Sbjct: 326 QPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPP---DRKPPLAAAL 382

Query: 399 TPTQQPG 405
              + PG
Sbjct: 383 GEAEPPG 389


>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
          Length = 2217

 Score =  101 bits (251), Expect = 2e-21
 Identities = 135/475 (28%), Positives = 165/475 (34%), Gaps = 112/475 (23%)

Query: 5    PPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQ 64
            P PP P  P       PP  P SA  +++D++               D  QG+     T 
Sbjct: 584  PGPPEPEEPEADQHLLPPTLPTSATSLASDST--------------FDSGQGS-----TV 624

Query: 65   INDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGG-KTG 123
             +D  + Q     G+  +   S      S P + G +     P L    Q   A G   G
Sbjct: 625  YSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGPVLPQSLPSLGAYQQPTAAPGLPVG 684

Query: 124  QGPGSRAP---SPRLPNKTIS-GPLIPPASPRLGNTSEAHGAARTAP------------P 167
              P    P       P+  +S  P++PP S     T    G  + AP            P
Sbjct: 685  SVPAPACPPSLQQHFPDPAMSFAPVLPPPS-----TPMPTGPGQPAPPGQQPPPLAQPTP 739

Query: 168  RPNVPAPPPPTP-PPPPPPLPPPLPSSSPIKT-----PLVSPPGPLTK-GNLPVVAPPVP 220
             P V AP P  P  P PP LPP L  +S +       PL  P  PL     +P   PP+P
Sbjct: 740  LPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQMPPIP 799

Query: 221  CAPP----------PP--PPPPPPTPPPLPPASVLSDKAVKPQL-APL-----HLP---- 258
              PP          PP  P  P  T PP+PP    S   + P L APL      LP    
Sbjct: 800  VVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAV 859

Query: 259  --PIPPPLPLLPPC----------------GYPGLKA------------EPASPAQDAQE 288
              P PP  PL  PC                  PG+ A            +P  PA   Q 
Sbjct: 860  KLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQM 919

Query: 289  PPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAP 348
             P   PP P +   + RA+ P P LP       T PP P   P    PPQ       P P
Sbjct: 920  APTDVPPSPHHTVQNMRATPPQPALP----PQPTLPPQPVLPPQPTLPPQPV---LPPQP 972

Query: 349  PAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQ 403
              PP  QP L  +    P      L P PA P R    +     Q A A TP  Q
Sbjct: 973  TRPP--QPVLPPQPMLPPQP---VLPPQPALPVRPEPLQPHLPEQAAPAATPGSQ 1022



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 116/401 (28%), Positives = 144/401 (35%), Gaps = 73/401 (18%)

Query: 2    PVPP---PPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTR 58
            P PP   PPP   P P P + AP P  P  P        L  A   G  A L  +Q    
Sbjct: 724  PAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQA 783

Query: 59   -LRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDV 117
             L+ + Q+  +  P       T   G           PP L DL     P + P      
Sbjct: 784  PLQPLAQVPPQMPPIPVVPPITPLAGIDGL-------PPALPDLPTATVPPVPP------ 830

Query: 118  AGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLG----NTSEAHGAARTAPPR---PN 170
                    P   +P+  LP+  ++ PL PPASP L           GA    P R   PN
Sbjct: 831  --------PQYFSPAVILPS--LAAPL-PPASPALPLQAVKLPHPPGAPLAMPCRTIVPN 879

Query: 171  VPAPPPPTPPPPPP-------------PLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAP 217
             PA  P     PP              P  P  P++ P   P   PP P          P
Sbjct: 880  APATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATP 939

Query: 218  PVPCAPPPPPPPPPPTPPP---LPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPG 274
            P P  PP P  PP P  PP   LPP  VL  +  +P    L   P+ PP P+LPP     
Sbjct: 940  PQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALP 999

Query: 275  LKAEPASPAQDAQEPPAPPP--------PLPPYASCS--------PRASLPAPPLPGV-- 316
            ++ EP  P    Q  PA  P        P P     +        P A++ +PPLP V  
Sbjct: 1000 VRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLL 1059

Query: 317  NSSSETPPPLPPK----SPSFQAPPQKAGAQALPAPPAPPG 353
             ++ E  P  P      S S Q+ P +      PA P  PG
Sbjct: 1060 PAAPELLPQFPSSLATVSASVQSVPTQTATLLPPANPPLPG 1100



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 124/493 (25%), Positives = 167/493 (33%), Gaps = 92/493 (18%)

Query: 2    PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRK 61
            PV   P P  P   PPL     P  S PP ++  S+  +                 +L  
Sbjct: 1317 PVAEHPAPEAPESSPPL-----PLSSLPPEASQDSAPYK----------------DQLSS 1355

Query: 62   VTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVL----RPA-GQRD 116
              Q +  ++ Q+ S  G +   G        S+PP       G  P       PA G   
Sbjct: 1356 KEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTAS 1415

Query: 117  VAGGK-TGQGPGSRAPSPRLPNKTISGPL-IPPASPRLGNTSEAHGAARTAPPRPNVPAP 174
             AGG  T QG  S   + +   +T   PL + P    L   + A  AA T     +  AP
Sbjct: 1416 QAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAASTR----DASAP 1471

Query: 175  PPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPP-PPPPPPPT 233
              P PPP P P P      S    P +  P PL    LP     V  A    P PP  PT
Sbjct: 1472 REPLPPPAPEPSP-----HSGTPQPALGQPAPL----LPAAVGAVSLATSQLPSPPLGPT 1522

Query: 234  PPPLPPASVLSD---------------KAVKPQLAPL----HLPPIPPPLPLLPPCGYPG 274
             PP PP+++ SD               K++  +L  L    H+P            G   
Sbjct: 1523 VPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRD 1582

Query: 275  LKAEPASPAQDAQEPPAPPPPLPPY--ASCSPRASLPAP--------PLPGV-----NSS 319
               EP    Q   E       LPP    + S R  LP P        P  G       SS
Sbjct: 1583 FTLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSS 1642

Query: 320  SETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKR---HGRPG--AGGGKLN 374
            S T    P     +    ++  + +   P  P     F++  R     R G  AG     
Sbjct: 1643 SMTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAE 1702

Query: 375  PPPAP------PARSPTTELSSKSQQATAWTPTQQ----PGGQLRNGSLHIIDDFESKFT 424
            PPP+        A  P T L +++  +    P QQ    P   +   S+    D  +  +
Sbjct: 1703 PPPSDMGTVGGQASHPQT-LGARALGSPRKRPEQQDVSSPAKTVGRFSVVSTQDEWTLAS 1761

Query: 425  FHSVEDFPPPDEY 437
             HS+    PPD Y
Sbjct: 1762 PHSLRYSAPPDVY 1774



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 88/341 (25%), Positives = 111/341 (32%), Gaps = 79/341 (23%)

Query: 3    VPPPPPP--------------PLPPPPPPL---GAPPPPPPSAP---------PVSTDTS 36
            VPP PPP              PLPP  P L       P PP AP         P +  T 
Sbjct: 825  VPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATI 884

Query: 37   SLRRADPKGRSALLADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPP 96
             L    P G +AL   I           +   + PQ+  +           N R     P
Sbjct: 885  PLLAVAPPGVAAL--SIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQP 942

Query: 97   TLGDL-FAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTI--SGPLIPP--ASPR 151
             L         PVL P  Q  +          +R P P LP + +    P++PP  A P 
Sbjct: 943  ALPPQPTLPPQPVLPP--QPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPV 1000

Query: 152  LGNTSEAHGAARTAP------------PRP---NVPAPPPPTPPPPPPPLPPPLPSSSPI 196
                 + H   + AP            P P   +V A  P  P PP   L PPLP     
Sbjct: 1001 RPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLLP 1060

Query: 197  KTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLH 256
              P + P  P    +L  V+  V          P  T   LPPA+               
Sbjct: 1061 AAPELLPQFP---SSLATVSASVQSV-------PTQTATLLPPAN--------------- 1095

Query: 257  LPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLP 297
             PP+P    +  PC    L  EP    Q +Q+    PP LP
Sbjct: 1096 -PPLPGGPGIASPCPTVQLTVEPVQEEQASQD---KPPGLP 1132



 Score = 32.3 bits (72), Expect = 0.99
 Identities = 40/176 (22%), Positives = 60/176 (34%), Gaps = 38/176 (21%)

Query: 262 PPLPLLPPCGYPGLKAEPASPAQDAQEPPAP----PPPLPPYASC--------------- 302
           PP+PL     Y     +P  P  + +EP A     PP LP  A+                
Sbjct: 567 PPVPLQVQVTYHAQAGQPGPP--EPEEPEADQHLLPPTLPTSATSLASDSTFDSGQGSTV 624

Query: 303 --SPRASLPAPPLPGVNSSSETP------------PPLPPKSPSFQAPPQKAGAQALPAP 348
               ++S  +  L  +  ++ +P            P LP   PS  A  Q   A  LP  
Sbjct: 625 YSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGPVLPQSLPSLGAYQQPTAAPGLPVG 684

Query: 349 PAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQP 404
             P  + P   ++    P      + PPP+ P  +   + +   QQ     P  QP
Sbjct: 685 SVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQQP---PPLAQP 737



 Score = 30.4 bits (67), Expect = 3.7
 Identities = 30/121 (24%), Positives = 37/121 (30%), Gaps = 15/121 (12%)

Query: 282 PAQDAQEPPAPPPPLP----PYASCSPRASL-------PAPPLPGVNSSSETPPPLP--- 327
           P  +A E P P PP P        C  R  +       PA P P    +    P  P   
Sbjct: 55  PGLEAAEAPGPQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADA 114

Query: 328 -PKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTT 386
            P+    Q P     A A+   PAP G           +   G  +  P P    R    
Sbjct: 115 GPEPVGTQEPGPDPIAAAVETAPAPDGGPREEAAATVRKEDEGAAEAKPEPGRTRRDEPE 174

Query: 387 E 387
           E
Sbjct: 175 E 175


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score =  100 bits (249), Expect = 3e-21
 Identities = 122/435 (28%), Positives = 160/435 (36%), Gaps = 93/435 (21%)

Query: 6   PPPPP----------LPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQ 55
           PPPPP          L  P  PLG PP P     P      +   ++  G +A       
Sbjct: 497 PPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAG-AAPCPPNPA 555

Query: 56  GTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQR 115
            + +  ++    R  P+  S + T     G ++  G  T P  G   AG  P   P    
Sbjct: 556 NSWVPGLSPGGSRRPPR--SPERTLSPSSGYSSQSGTPTLPPKG--LAG--PPASP---- 605

Query: 116 DVAGGKTGQGPGSRAPSPRLPNKTISGPLI--------PPASPRLG-NTSEAHGAARTAP 166
               GK       R  S R P  ++S  L         P  S R G       G     P
Sbjct: 606 ----GKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIP 661

Query: 167 PRPNVPAP--PPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPP 224
           P P VPAP  PPP+ P  P P  P L + + +       PGP++  +          A P
Sbjct: 662 PHPKVPAPFSPPPSKPRSPNPAAPALAAPAVV-------PGPVSTTD----------ASP 704

Query: 225 PPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPL--PLLPPCGYPGLKAEPASP 282
             PP P  T  PL  + V+S K   P       PP PPP   P  PP   P +  E  S 
Sbjct: 705 QSPPTPQTTLTPLQESPVIS-KDQSP-------PPSPPPSYHPPPPPTKKPEVVVEAPSA 756

Query: 283 AQDAQEP------PAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAP 336
           ++ A+EP      P PPPP P     S  A  P PP     S +   P  P  SP   + 
Sbjct: 757 SETAEEPLQDPNWPPPPPPAPEEQDLS-MADFP-PPEEAFFSVASPEPAGPSGSPELVSS 814

Query: 337 PQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQAT 396
           P  + + A      PPGS                   +PPPAPPA +P    +S +    
Sbjct: 815 PAASSSSATALQIQPPGSP------------------DPPPAPPAPAP----ASSAPGHV 852

Query: 397 AWTPTQQPGGQLRNG 411
           A  P ++P G  + G
Sbjct: 853 AKLPQKEPVGCSKGG 867



 Score = 79.0 bits (193), Expect = 9e-15
 Identities = 116/450 (25%), Positives = 146/450 (32%), Gaps = 94/450 (20%)

Query: 10  PLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRS 69
           P  PP    G P  P  + PP     +SLR       S+L +     +        +DRS
Sbjct: 591 PTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSD----PAPSDRS 646

Query: 70  APQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSR 129
            PQI                                   L P G R V        P  +
Sbjct: 647 GPQI-----------------------------------LTPLGDRFVI------PPHPK 665

Query: 130 APSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPP 189
            P+P  P         PP+ PR  N +    AA    P P       P  PP P     P
Sbjct: 666 VPAPFSP---------PPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTP 716

Query: 190 LPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPP--LPPASVLSDKA 247
           L  S  I      PP P                PP   PPPPPT  P  +  A   S+ A
Sbjct: 717 LQESPVISKDQSPPPSP----------------PPSYHPPPPPTKKPEVVVEAPSASETA 760

Query: 248 VKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRAS 307
            +P   P + PP PPP P               +    A   PA P   P   S    +S
Sbjct: 761 EEPLQDP-NWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASS 819

Query: 308 LPAPPLPGVNSSSETPPPLPP-KSPSFQAP------PQK--AGAQALPAPP-----APPG 353
             A  L      S  PPP PP  +P+  AP      PQK   G      PP     AP  
Sbjct: 820 SSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLV 879

Query: 354 SQPFLQKKRHGRPGAGGGKLNPP--PAPPARSPTTELSSKSQQATAWTPTQQPGGQLRNG 411
           +   LQ  R    GA GG   P   P+ P +     LS ++    A +       +L+  
Sbjct: 880 TPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKAC 939

Query: 412 SLHIIDDFESKFTFHSVEDFPPPDEYKPCQ 441
           SL   +   S     +  + PP  E +P Q
Sbjct: 940 SLAASEGLSS-----AQPNGPPEAEPRPPQ 964



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 104/391 (26%), Positives = 135/391 (34%), Gaps = 95/391 (24%)

Query: 117 VAGGKTGQGPGSRAPSPRLPNKTISGPLIPP-------ASPRLGNTSEAHG--AARTAPP 167
           V+ G T    G     P   + T S  ++PP        SP  G+T+EA    + R++  
Sbjct: 426 VSDGSTLSSKGGSEGQPE--SSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQ 483

Query: 168 RPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPP 227
                        PPPPP      + S  +  L  P GPL         PP P     P 
Sbjct: 484 LSGRSVSLRKLKRPPPPPRR----THSLHQRGLAVPDGPLG-------LPPKPERKQQPQ 532

Query: 228 PPPPPTP--------PPLPPASVLSDKAVKPQLAP--LHLPPIPPPLPLLPPCGYPGLKA 277
            P PPT          P PP    S     P L+P     PP  P   L P  GY     
Sbjct: 533 LPRPPTTGGSEGAGAAPCPPNPANS---WVPGLSPGGSRRPPRSPERTLSPSSGYSSQSG 589

Query: 278 EPASPAQDAQEPPAPP----PPLPPYASC--SPRASLPAPPLPGVNSSSE---------- 321
            P  P +    PPA P    PP P   +   SP AS+ +      +SSS+          
Sbjct: 590 TPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQ 649

Query: 322 ---------------------TPPPLPPKSPSFQAPPQKAGA---------QALP-APPA 350
                                +PPP  P+SP+  AP   A A          A P +PP 
Sbjct: 650 ILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPT 709

Query: 351 PPGSQPFLQK-----KRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQPG 405
           P  +   LQ+     K    P +     +PPP PP + P   + + S   TA  P Q P 
Sbjct: 710 PQTTLTPLQESPVISKDQSPPPSPPPSYHPPP-PPTKKPEVVVEAPSASETAEEPLQDPN 768

Query: 406 GQLRNGSLHIIDDFESKFTFHSVEDFPPPDE 436
                       D        S+ DFPPP+E
Sbjct: 769 WPPPPPPAPEEQDL-------SMADFPPPEE 792



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 98/411 (23%), Positives = 130/411 (31%), Gaps = 61/411 (14%)

Query: 3    VPPPPPPPLPPPPPPLGAPPPPPPSAP----------PVSTDTSSLRRADPKGRSALLAD 52
            +PP P  P P  PPP   P  P P+AP          PVST  +S +   P      L  
Sbjct: 660  IPPHPKVPAPFSPPP-SKPRSPNPAAPALAAPAVVPGPVSTTDASPQ--SPPTPQTTLTP 716

Query: 53   IQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPA 112
            +Q+   + K         P         K+         AS             P   PA
Sbjct: 717  LQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPA 776

Query: 113  GQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVP 172
             +           P     S   P      P  P  SP L ++  A  ++ TA     + 
Sbjct: 777  PEEQDLSMADFPPPEEAFFSVASPE-----PAGPSGSPELVSSPAASSSSATA-----LQ 826

Query: 173  APPPPTPPPPPPPLPPPLPSSSP---IKTPLVSPPGPLTKGNLPVVAPPVPCAPPP---- 225
              PP +P PPP P  P   SS+P    K P   P G    G  P      P   P     
Sbjct: 827  IQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQM 886

Query: 226  ------------PPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYP 273
                        P P   P+ P  P    LS +A  P  AP         L         
Sbjct: 887  VRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRA-SPVPAPSSGLHAAVRLKACSLAASE 945

Query: 274  GLK-AEPASPAQDAQEPPAPPPPLPPY--ASCSPRASLPAPPLPGVNS------------ 318
            GL  A+P  P +    PP  P     +  +  S +  L  P  P   +            
Sbjct: 946  GLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRS 1005

Query: 319  -SSETPPPLPPKSPSFQAPPQKAGAQALPAPPAP--PGSQPFLQKKRHGRP 366
             S + PP  P KSP    P  +  +  +P P +P  P ++P      +G P
Sbjct: 1006 ISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLP 1056



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 54/224 (24%), Positives = 74/224 (33%), Gaps = 22/224 (9%)

Query: 2    PVPPPPPPPLPPPPPPLGAPP---PPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTR 58
            P   P PPP PP P P  + P      P   PV          +  G   +   + Q  R
Sbjct: 829  PPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVR 888

Query: 59   LRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTP-PTLGDLFAGGFPVLRPAGQRDV 117
            LR V        P +  S    K    + + R +  P P+ G   A        A    +
Sbjct: 889  LRSVGAPGGAPTPALGPS-APQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGL 947

Query: 118  AGGKTGQGPGSRAPSPRLPNKTISG---------PLIPPASP------RLGNTSEAHGAA 162
            +  +    P +    P+ P  T S           L  P SP      +    +E    +
Sbjct: 948  SSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSIS 1007

Query: 163  RTAPPR--PNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPP 204
               PP+     P  PPP    P   +PPP   S P   PL +PP
Sbjct: 1008 EQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPP 1051



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 51/193 (26%), Positives = 64/193 (33%), Gaps = 34/193 (17%)

Query: 290 PAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALP--- 346
           P  P  LPP      +  LP PP  G  S      P PP   +   P    G    P   
Sbjct: 515 PDGPLGLPPKPERKQQPQLPRPPTTG-GSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRS 573

Query: 347 -----APPAPPGSQ---PFLQKKRHGRPGAGGGKLNPPP-------APPARSPTTELSSK 391
                +P +   SQ   P L  K    P A  GK  PP          P  S ++ L+S 
Sbjct: 574 PERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSL 633

Query: 392 SQQATAWTPTQQPGGQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRS 451
              ++   P+ + G Q       I+     +F         PP    P     P   PRS
Sbjct: 634 CSSSSDPAPSDRSGPQ-------ILTPLGDRFVI-------PPHPKVPAPFSPPPSKPRS 679

Query: 452 RTP-GPWLQAEAV 463
             P  P L A AV
Sbjct: 680 PNPAAPALAAPAV 692


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 130/480 (27%), Positives = 174/480 (36%), Gaps = 60/480 (12%)

Query: 3   VPPPPPPPLPPPPPPLGAPPP-------PPPSAPPVSTDTSSLRRADPKGRSALLADIQQ 55
           +PPP   PL PPP      PP       PPP   P S    +L  + P   S L    ++
Sbjct: 441 LPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEE 500

Query: 56  GTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQR 115
                     +   +P  ES     +E   S       +PP            L P  + 
Sbjct: 501 SP--LSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEAS-------PLSPPFEE 551

Query: 116 DVAGGKTGQGPGSRAP-SPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAP 174
                   + P S  P + RL       P+ PP  P     S    A+R  PP    P  
Sbjct: 552 SPLSPPPEELPTSPPPEASRLSPPPEESPMSPP--PEESPMSPPPEASRLFPPFEESPLS 609

Query: 175 PPP-----TPPPPPPPLPPPLPSSSPI-----KTPLVSPPGPLTKGNLPVV---APPVPC 221
           PPP     +PPP    L PP P  SP+     ++P+  PP       LPVV   +PP   
Sbjct: 610 PPPEESPLSPPPEASRLSPP-PEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEE 668

Query: 222 APPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPAS 281
           +P  PPP   PT PP P AS LS     P+ +P   PP   P    P      L  E + 
Sbjct: 669 SPLSPPPEESPTSPP-PEASRLSP---PPEDSPTSPPPEDSPASPPPEDSLMSLPLEESP 724

Query: 282 PAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLP-PKSPSFQAPPQKA 340
                +EP   P    P+ S       P P  P ++   E P   P  + P     P++ 
Sbjct: 725 LLPLPEEPQLCPRSEGPHLS-------PRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEP 777

Query: 341 GAQALPAPP--APPGSQPFLQ---KKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQA 395
              A+P  P  +P    P L    ++ H  P      L+P P  P  SP  E S  S Q 
Sbjct: 778 CLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQ- 836

Query: 396 TAWTPTQQPGGQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRTPG 455
                +++P    R    H+  + E      S     PP+E  P Q   P ++P    PG
Sbjct: 837 -----SEEPCLSPRPEESHLSPELEKPPL--SPRPEKPPEE--PGQCPAPEELPLFPPPG 887



 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 92/289 (31%), Positives = 116/289 (40%), Gaps = 48/289 (16%)

Query: 133 PRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPP--------------T 178
           P LP    S PL PP  P    TS    A+R +PP   +PA P P              +
Sbjct: 439 PLLPPPEES-PLSPP--PEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLS 495

Query: 179 PPPPPPPLPPPLPSS-------SPIKTPLVSPPGPLTKGNL------PVVAPPVPCAPPP 225
           PPP   PL PP  SS       SP+  P  SPP P  +  L        ++PP   +P  
Sbjct: 496 PPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLS 555

Query: 226 PPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCG--YPGLKAEPASPA 283
           PPP   PT PP P AS LS     P+ +P+  PP   P+   P     +P  +  P SP 
Sbjct: 556 PPPEELPTSPP-PEASRLSP---PPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSP- 610

Query: 284 QDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQ 343
              +E P  PPP     S  P  S  +PP        E  P  PP   S +  P    ++
Sbjct: 611 -PPEESPLSPPPEASRLSPPPEDSPMSPP-------PEESPMSPPPEVS-RLSPLPVVSR 661

Query: 344 ALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKS 392
             P P   P S P   ++    P     +L+PPP     SP  E S  S
Sbjct: 662 LSPPPEESPLSPP--PEESPTSPPPEASRLSPPPEDSPTSPPPEDSPAS 708



 Score = 92.4 bits (228), Expect = 8e-19
 Identities = 115/436 (26%), Positives = 149/436 (34%), Gaps = 73/436 (16%)

Query: 5   PPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQ 64
           P  PP   PP P L  P  PPP A P+S          P       +   + +RL    +
Sbjct: 519 PLSPPEESPPSPALETPLSPPPEASPLSPPFEE-SPLSPPPEELPTSPPPEASRLSPPPE 577

Query: 65  INDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQ 124
            +  S P  ES                 S PP    LF        P  +         +
Sbjct: 578 ESPMSPPPEESP---------------MSPPPEASRLF--------PPFEESPLSPPPEE 614

Query: 125 GPGSRAP-SPRLPNKTISGPLIPPAS-------PRLGNTSEAHGAARTAPPRPNVPAPPP 176
            P S  P + RL       P+ PP         P +   S     +R +PP    P  PP
Sbjct: 615 SPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPP 674

Query: 177 P--TPPPPPP------PLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPP-- 226
           P  +P  PPP      P P   P+S P +    SPP   +  +LP+   P+   P  P  
Sbjct: 675 PEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQL 734

Query: 227 ----------PPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPP----IPPPLPLLPPCGY 272
                     P P  P   P P    LS +A +P L+P    P    +P    L P    
Sbjct: 735 CPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEG 794

Query: 273 PGLKAEPAS--PAQDAQEPPAPPPPLPPYASCSPRASLPAPP-----LPGVNSSSETPPP 325
           P L  +P     +   +EP   P P  P  S  P  S  +P      L      S   P 
Sbjct: 795 PHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPE 854

Query: 326 L--PPKSPSFQAPPQKAGAQALP------APPAPPGSQPFLQKKRHGRPGAGGGKLNPPP 377
           L  PP SP  + PP++ G    P       PP  P   P L +     PG     L+P P
Sbjct: 855 LEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGE--PPLSPLP 912

Query: 378 APPARSPTTELSSKSQ 393
                SP+ E S   Q
Sbjct: 913 EELPLSPSGEPSLSPQ 928



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 114/424 (26%), Positives = 143/424 (33%), Gaps = 83/424 (19%)

Query: 1   MPVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSAL--------LAD 52
           +P  PPP      PPP    P  PPP   P+S    + R   P   S L        L+ 
Sbjct: 561 LPTSPPPEASRLSPPPEES-PMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSP 619

Query: 53  IQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPA 112
             + +RL    + +  S P  ES                 S PP +  L     PV+   
Sbjct: 620 PPEASRLSPPPEDSPMSPPPEESP---------------MSPPPEVSRL--SPLPVV--- 659

Query: 113 GQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVP 172
                                RL       PL PP  P    TS    A+R +PP  + P
Sbjct: 660 --------------------SRLSPPPEESPLSPP--PEESPTSPPPEASRLSPPPEDSP 697

Query: 173 APPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPG-----PLTKGNLPVVAPPVPCAPPPPP 227
             PPP   P  PP    L S    ++PL+  P      P ++G      P  P   P P 
Sbjct: 698 TSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPE 757

Query: 228 PP--------PPPTPPPLPP--ASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKA 277
            P        P  +P P  P   +V  +  + PQ    HL P P  L L P    P L  
Sbjct: 758 EPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSP 817

Query: 278 EPASPAQDAQ--EPPAPPPPLPPYASCSPRASLPAPPL--PGVNSSSETPP------PLP 327
            P  P    Q  E    P    P  S  P  S  +P L  P ++   E PP      P P
Sbjct: 818 VPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAP 877

Query: 328 PKSPSFQAPPQKA-----GAQALPAPPAPPGS--QPFLQKKRHGRPGAGGGKLNPPPAPP 380
            + P F  P + +     G  AL  P  PP S     L     G P      + P P PP
Sbjct: 878 EELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPP 937

Query: 381 ARSP 384
             SP
Sbjct: 938 PLSP 941



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 90/280 (32%), Positives = 110/280 (39%), Gaps = 38/280 (13%)

Query: 123 GQGPGSRAPS--PRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPP 180
           GQ  G    S  P+ P     GPL   A P LG           AP    +P  PPP   
Sbjct: 394 GQPKGGHVTSMQPKEP-----GPLQCEAKP-LGKAGVQLEPQLEAPLNEEMPLLPPPEES 447

Query: 181 PPPPPLPPPLPSSSPIKTPLVS-PPGPLTKGNLPV---VAPPVPCAPPPPPPPPPPTPPP 236
           P  PP P   P+S P +   +S PP  L    LP    ++ P+  +P  PPP   P  PP
Sbjct: 448 PLSPP-PEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPP 506

Query: 237 LPPASVLSDKAVKPQLAPLHLPPIPP-PLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPP 295
            P +S  S     P   P   PP P    PL PP      +A P SP    +E P  PPP
Sbjct: 507 -PESSPFSPLEESPLSPPEESPPSPALETPLSPP-----PEASPLSP--PFEESPLSPPP 558

Query: 296 LPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALP---APPAPP 352
                S  P AS  +PP        E  P  PP   S  +PP +A     P   +P +PP
Sbjct: 559 EELPTSPPPEASRLSPP-------PEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPP 611

Query: 353 GSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKS 392
             +  L       P     +L+PPP     SP  E S  S
Sbjct: 612 PEESPLS------PPPEASRLSPPPEDSPMSPPPEESPMS 645



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 118/413 (28%), Positives = 144/413 (34%), Gaps = 91/413 (22%)

Query: 2    PVPPPPP--PPLPPP------PPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALL--- 50
            P+ PPP   P  PPP      PPP  +P  PPP   P S        + P   S LL   
Sbjct: 670  PLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLP 729

Query: 51   -----ADIQQGTRLRKVTQINDRS--------APQIESSK-----------GTNKEGGGS 86
                     +G  L    +    S        +PQ E                 +E   S
Sbjct: 730  EEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLS 789

Query: 87   ANTRGASTPPTLGDLFAGGF---PVLRPAGQRDVAGGKTGQG---PGSRAP--SPRLPNK 138
                G    P   +L        P L P  +      +  +    P S  P  SPR    
Sbjct: 790  PQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEES 849

Query: 139  TISGPLI-PPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPL--PPPLPSSSP 195
             +S  L  PP SPR              P +P  P  P   P P   PL  PP  PS SP
Sbjct: 850  HLSPELEKPPLSPR--------------PEKP--PEEPGQCPAPEELPLFPPPGEPSLSP 893

Query: 196  IK-TPLVSPPGPLTKGNLPVVAPPVPCAPPPPPP---PPPPTPPPLPPASVLSDKAVKPQ 251
            +   P +S PG      LP   P  P   P   P   PP P PPPL P   +   A  P 
Sbjct: 894  LLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSP---IITAAAPPA 950

Query: 252  LAPLHLPPIPPPLPLLPPCGYPGLKAEPASP-AQDAQEPPAPPPPLPPYASCSPRASLPA 310
            L+PL          L  P G  G  ++P SP A    E P  PPP        P   +  
Sbjct: 951  LSPLG--------ELEYPFGAKG-DSDPESPLAAPILETPISPPPEANCTDPEPVPPMIL 1001

Query: 311  PPLPGVNSSSETP---PPLPPK-SPSFQ-------APPQKAGAQALP-APPAP 351
            PP PG      +P    PLPP+ SP  Q       +PP +    ALP + P+P
Sbjct: 1002 PPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSP 1054



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 139/505 (27%), Positives = 164/505 (32%), Gaps = 130/505 (25%)

Query: 5    PPPPPPLPPPPPPLGAPPPPP---PSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRK 61
            P  PP  PP P P GAP  PP    S+ P +          P G               +
Sbjct: 2190 PTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPP-GTPRHQPSTPDPFLKPR 2248

Query: 62   VTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGK 121
               +++ + P+   S G    GGG A+    S PP  G+            G    + G 
Sbjct: 2249 CPSLDNLAVPE---SPGV---GGGKASEPLLSPPP-FGESRKALEVKKEELGASSPSYGP 2301

Query: 122  TGQG----PGSRAPSPRLPNKT---ISGPLIP------PASPRLG-NTSEAHGAARTAPP 167
               G    P S      L  KT      PL P      P SP LG    E   A   AP 
Sbjct: 2302 PNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPS 2361

Query: 168  RPNVP------------APPPPTPPPPPPP------LPPPLPSSSPIKTPLVSPPG---- 205
             P+ P            A PP TP P PPP      LPP    S P      SP      
Sbjct: 2362 PPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSS 2421

Query: 206  --PLTKGNLPVVA-PPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPP 262
              PLT   L   A  P P  P    P P   PP  P +        +   APLH PP P 
Sbjct: 2422 QSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQS--------RDPFAPLHKPPRPQ 2473

Query: 263  PLPL-----------LPPCGYPGLKAEPASPAQD--AQEPPAPPP--------------P 295
            P  +           L   G+P   A PA PA +  A+ P   PP              P
Sbjct: 2474 PPEVAFKAGSLAHTSLGAGGFPA--ALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTP 2531

Query: 296  LP-----PYASCSP--RASLPAPPLP---GVNSSSETPPPL------------------- 326
             P     P A   P  +  +P P LP   G+NS     P L                   
Sbjct: 2532 SPMRFTFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSG 2591

Query: 327  PPKSPSFQAPPQKAGAQALP-----APPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPA 381
             P  PS  +  +  G   L       PPAP GS P+L      R G         P    
Sbjct: 2592 SPLGPSSGSTGESYGLSPLRPPSVLPPPAPDGSLPYLSHGASQRSGI------TSPVEKR 2645

Query: 382  RSPTTELSSKSQQATAWTP-TQQPG 405
              P T +   S  ATA  P TQ PG
Sbjct: 2646 EDPGTGMG--SSLATAELPGTQDPG 2668



 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 70/244 (28%), Positives = 88/244 (36%), Gaps = 50/244 (20%)

Query: 176 PPTPPPPPPPLPPPL-------PSSSPIKTPLVSPPGPLT-----KGNLPVVAPP----- 218
           PP P   P   P  L       P    + +     PGPL       G   V   P     
Sbjct: 374 PPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEAP 433

Query: 219 ----VPCAPPP------PPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLP 268
               +P  PPP      PPP   PT PP P AS LS     P    L   P+P  L L  
Sbjct: 434 LNEEMPLLPPPEESPLSPPPEESPTSPP-PEASRLS-----PPPEELPASPLPEALHLSR 487

Query: 269 PCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLP---APPLPGVNSSSETPPP 325
           P     L+  P SP  + + P +PPP   P++        P   +PP P + +    PP 
Sbjct: 488 P-----LEESPLSPPPE-ESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPE 541

Query: 326 LPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPT 385
             P SP F+  P     + LP  P P  S+          P      ++PPP     SP 
Sbjct: 542 ASPLSPPFEESPLSPPPEELPTSPPPEASRL--------SPPPEESPMSPPPEESPMSPP 593

Query: 386 TELS 389
            E S
Sbjct: 594 PEAS 597



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 122/453 (26%), Positives = 158/453 (34%), Gaps = 90/453 (19%)

Query: 11   LPPPPPPLGAPPPPPPSAP---------PVSTDTSSLRRADPKGRSALLADIQQGTRLRK 61
            +PP P  LG+  PPP +AP         P    TS+     P   S    D      L+ 
Sbjct: 2106 IPPQPGALGS--PPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKL 2163

Query: 62   VTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTL----GDLFAGGFPVLRPAGQRDV 117
              Q+      Q+ S              R  + PPT         A   P +  A  R  
Sbjct: 2164 PPQV----PAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPG 2219

Query: 118  AGGKTGQ----GPGSRAPSPRLPNKTISGPLIPPASPRLGNTS--EAHGAARTAPPRPNV 171
            A G+ G+     PG+    P  P+     P + P  P L N +  E+ G        P +
Sbjct: 2220 A-GQPGEFHTTPPGTPRHQPSTPD-----PFLKPRCPSLDNLAVPESPGVGGGKASEPLL 2273

Query: 172  PAPP----------------PPTPPPPPPPLP-PPLPSSS------PIKTPLVSPPGPLT 208
              PP                  +P   PP L     PSS        +KTP V    PLT
Sbjct: 2274 SPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVF-KAPLT 2332

Query: 209  --KGNLPVVAPPVPCAPPPPPP-----PPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIP 261
                 +   +P +   P  PPP     P PP+ P +      +D   +P L P   PP P
Sbjct: 2333 PRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPP 2392

Query: 262  PPLPLLPPCGYPG--LKAEPASP-AQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNS 318
                 LPP   P       PASP +Q + + P  P PL   A C      P+P  P   S
Sbjct: 2393 ESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFC------PSPVTPRFQS 2446

Query: 319  SSE-TPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPP 377
                + PP  P+S    AP  K      P  P PP          H   GAGG     P 
Sbjct: 2447 PDPYSRPPSRPQSRDPFAPLHK------PPRPQPPEVAFKAGSLAHTSLGAGGF----PA 2496

Query: 378  APPARSPTTELSSKSQQATAWTPTQQPGGQLRN 410
            A PA  P  EL +K        P+ QP   +R+
Sbjct: 2497 ALPA-GPAGELHAK-------VPSGQPPNFVRS 2521



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 74/268 (27%), Positives = 97/268 (36%), Gaps = 32/268 (11%)

Query: 161  AARTAPPRPNVPAPPPPTP-PPPPPPLPPPLPSSSP-------------IKTPLVSPPGP 206
            A +T  P  ++  PP P     PPP   P +   SP             +K P  S PGP
Sbjct: 2094 ARKTDRPALHLRIPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGP 2153

Query: 207  LTKGNLPVVAPP-VPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPL- 264
             + G L +  PP VP   P   P       PL P    +     P  +P   P  PP L 
Sbjct: 2154 DSPGELFLKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLG 2213

Query: 265  -PLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETP 323
                P  G PG +     P     +P  P P L P   C    +L  P  PGV     + 
Sbjct: 2214 ASSRPGAGQPG-EFHTTPPGTPRHQPSTPDPFLKP--RCPSLDNLAVPESPGVGGGKASE 2270

Query: 324  PPL--PPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPA 381
            P L  PP   S +A   K       +P   P +  F+     G    GG +L  P     
Sbjct: 2271 PLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSG-THLGGLELKTPDV--F 2327

Query: 382  RSPTTELSSKSQQATAWTPTQQPGGQLR 409
            ++P T  +S+ +        Q PG  LR
Sbjct: 2328 KAPLTPRASQVE-------PQSPGLGLR 2348



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 28/70 (40%), Positives = 37/70 (52%), Gaps = 2/70 (2%)

Query: 222  APPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLL--PPCGYPGLKAEP 279
            APPP  P PPP+P    PAS  ++  V+    PL  PP+P PLPL   P    P  +A P
Sbjct: 4908 APPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPRARP 4967

Query: 280  ASPAQDAQEP 289
                +D++ P
Sbjct: 4968 PEEGEDSRPP 4977



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 91/382 (23%), Positives = 127/382 (33%), Gaps = 43/382 (11%)

Query: 5    PPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQ 64
            PP  P    P  PL  PP P P  P V+    SL      G     A +  G       +
Sbjct: 2453 PPSRPQSRDPFAPLHKPPRPQP--PEVAFKAGSLAHTS-LGAGGFPAALPAGPAGELHAK 2509

Query: 65   INDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPA----GQRDVAGG 120
            +     P    S GT    G  +  R  + P  +G+      P L+P     G     G 
Sbjct: 2510 VPSGQPPNFVRSPGTGAFVGTPSPMR-FTFPQAVGE------PSLKPPVPQPGLPPPHGI 2562

Query: 121  KTGQGPGSRAPSPRLPNKTISG----PLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPP 176
             +  GPG     P+  N T++     P   P  P  G+T E++G +   PP       PP
Sbjct: 2563 NSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPS----VLPP 2618

Query: 177  PTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTP-P 235
            P P    P L       S I +P+     P T     +    +P    P       T   
Sbjct: 2619 PAPDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSLATAELPGTQDPGMSGLSQTELE 2678

Query: 236  PLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPC-GYPGL-KAEPASPAQDAQEPPAPP 293
                   L +  ++ Q+    L              G PG   AEP+SPA +       P
Sbjct: 2679 KQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGAEPSSPAFEQLSRGQTP 2738

Query: 294  PPLPPYASCSPRASLPAPP-------------LPGVNSSSETPPPLPPKSPSFQAPPQKA 340
                 +A    ++SL   P              P  +  S  PPP  P S    +     
Sbjct: 2739 -----FAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPPATPSSMDVNSRQLVG 2793

Query: 341  GAQALPAPPAPPGSQPFLQKKR 362
            G+QA       PGS P  Q+++
Sbjct: 2794 GSQAFYQRAPYPGSLPLQQQQQ 2815



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 103/418 (24%), Positives = 125/418 (29%), Gaps = 100/418 (23%)

Query: 4    PPPPPPPLPPPP------PPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGT 57
            P P   PL PPP      P LG P    P  PP+S     L  + P G  +L   +    
Sbjct: 875  PAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLS-PSGEPSLSPQLMPPD 933

Query: 58   RLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLF-AGGFPVLRPAGQRD 116
             L                                   PP L  +  A   P L P G+ +
Sbjct: 934  PL-----------------------------------PPPLSPIITAAAPPALSPLGELE 958

Query: 117  VAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPP 176
               G  G       P   L    +  P+ PP  P    T          PP P  P  P 
Sbjct: 959  YPFGAKGDSD----PESPLAAPILETPISPP--PEANCTDPEPVPPMILPPSPGSPVGPA 1012

Query: 177  ------PTPP---------------------PPPPPLPPPLPSSSPIKTPLVSPPGPLTK 209
                  P PP                     PP  PL  P P S   K   VS    L +
Sbjct: 1013 SPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGVSDEAELHE 1072

Query: 210  GNLPVVAPPVPCAPPPPPPPPPPTP------PPLPPASVLSD-KAVKPQLAPLHLPPIPP 262
                 V+ P   A  P    P P+P      P   PA  L D   +    APL     P 
Sbjct: 1073 METEKVSEPECPALEPSATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPG 1132

Query: 263  PLPLLPPCGYPGLKAE--PASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSS 320
              P   P   PG  A     SP     E  AP  P+  Y  C   A   +P         
Sbjct: 1133 SQP--EPGQTPGSLASELKGSPVLLDPEELAPVTPMEVYPECKQTAGQGSP----CEEQE 1186

Query: 321  ETPPPLPPKSPSF---QAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPG-AGGGKLN 374
            E   P+ P  P+        + +      A  + PGS+P L     G P   GGG L+
Sbjct: 1187 EPRAPVAPTPPTLIKSDIVNEISNLSQGDASASFPGSEPLL-----GSPDPEGGGSLS 1239



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 83/323 (25%), Positives = 107/323 (33%), Gaps = 51/323 (15%)

Query: 107  PVLRPAGQRD--------VAGGKTGQ-GPGSRAPSPRLPNKTISGPLIPPASPRLGNTSE 157
            P LR  GQ+           GG  GQ G GS + +  +P+      L+   S  LG+   
Sbjct: 4093 PPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPH------LLAQPSVSLGDQPG 4146

Query: 158  AHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAP 217
            +       P +P +  P      P PP   P L S   +    + P     +  L  V  
Sbjct: 4147 SMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLA 4206

Query: 218  PVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPP-PLPLLPPC-----G 271
              P      P         L    +   +AV+ Q  P   P     PL  L  C     G
Sbjct: 4207 KNPQLRHLSPQQQQQLQALLMQRQLQQSQAVR-QTPPYQEPGTQTSPLQGLLGCQPQLGG 4265

Query: 272  YPGLKAEPASPAQDAQEPPAPPP-PLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKS 330
            +PG +  P         P  PP  P PP A  +     P  P P  +S  E   P    S
Sbjct: 4266 FPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPS 4325

Query: 331  PSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPP---APPARSPTTE 387
            PS Q P +         PP  PG+           P   G  L PPP   +P A      
Sbjct: 4326 PSSQLPTE------AQLPPTHPGT-----------PKPQGPTLEPPPGRVSPAAAQLADT 4368

Query: 388  LSSKSQQATAWTP------TQQP 404
            L SK      W P      TQ+P
Sbjct: 4369 LFSKG--LGPWDPPDNLAETQKP 4389



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 32/99 (32%), Positives = 41/99 (41%), Gaps = 5/99 (5%)

Query: 227  PPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDA 286
            P P PPT         +S+  V+   AP    P PPP PL P    P  +     P +  
Sbjct: 4884 PAPEPPTQHSY--TYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPL 4941

Query: 287  QEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPP 325
             EPP P P   P AS SP ++ P P         ++ PP
Sbjct: 4942 AEPPVPSP--LPLAS-SPESARPKPRARPPEEGEDSRPP 4977



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 23/62 (37%), Positives = 28/62 (45%), Gaps = 3/62 (4%)

Query: 175  PPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTP 234
            PPP  P PPP    P P+S P +  +  P  PL +   P V  P+P A  P    P P  
Sbjct: 4909 PPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAE---PPVPSPLPLASSPESARPKPRA 4965

Query: 235  PP 236
             P
Sbjct: 4966 RP 4967



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 55/242 (22%), Positives = 85/242 (35%), Gaps = 32/242 (13%)

Query: 1    MPVPPPPPPPLPPPPPPLGAPPPP-----------PPSAPPVSTDTSSLRRADPKGRSAL 49
            M +PP P  P+ P  P L  P PP           P ++PP      +L  + P   S +
Sbjct: 999  MILPPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSPLSPI 1058

Query: 50   --LADIQQGTRLRKV--TQINDRSAPQIE-SSKGTNKEGGGSANTRGASTPPTLGDLFAG 104
              +  +     L ++   ++++   P +E S+        G  +    S  P L D F+G
Sbjct: 1059 GKVVGVSDEAELHEMETEKVSEPECPALEPSATSPLPSPMGDLSCPAPSPAPALDD-FSG 1117

Query: 105  GFPVLRPAGQRDVAGG--KTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAA 162
                  P    D  G   + GQ PGS A   +     +    + P +P +    E    A
Sbjct: 1118 LGEDTAPLDGIDAPGSQPEPGQTPGSLASELKGSPVLLDPEELAPVTP-MEVYPECKQTA 1176

Query: 163  RTAPPRPNVPAPPPPTPPPPPPPLPPPL------------PSSSPIKTPLVSPPGPLTKG 210
                P      P  P  P PP  +   +             +S P   PL+  P P   G
Sbjct: 1177 GQGSPCEEQEEPRAPVAPTPPTLIKSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGG 1236

Query: 211  NL 212
            +L
Sbjct: 1237 SL 1238



 Score = 37.7 bits (86), Expect = 0.023
 Identities = 28/88 (31%), Positives = 33/88 (37%), Gaps = 9/88 (10%)

Query: 154  NTSEAHGAARTAPP--RPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGN 211
            N S       +APP   P+     PP+P  P P  PP  P       PL  PP P     
Sbjct: 4897 NVSNLDVRQLSAPPPEEPSP----PPSPLAPSPASPPTEPLVELPTEPLAEPPVP---SP 4949

Query: 212  LPVVAPPVPCAPPPPPPPPPPTPPPLPP 239
            LP+ + P    P P   PP       PP
Sbjct: 4950 LPLASSPESARPKPRARPPEEGEDSRPP 4977



 Score = 36.6 bits (83), Expect = 0.052
 Identities = 91/393 (23%), Positives = 124/393 (31%), Gaps = 54/393 (13%)

Query: 4    PPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVT 63
            PP PP  LPP PPP           P           A  +     L D  +   L  + 
Sbjct: 4619 PPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSERALRDTSEVKSLDLLA 4678

Query: 64   QINDRSAPQIESSKGTNKEGGGSANTR-GASTPPTLGDLFAGGFPVLRPAGQRDVAGGKT 122
             +      Q E  +  + E   S ++   AS+P ++    A  FP L          G+ 
Sbjct: 4679 ALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPHL--------GSGRW 4730

Query: 123  GQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPP 182
             Q    RA SP +P       LIP AS  +   ++ +GA         VP   P T    
Sbjct: 4731 EQE--DRALSPVIP-------LIPRASIPVFPDTKPYGALGL-----EVPGKLPVTT--- 4773

Query: 183  PPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPP-------PPPPPPPPTPP 235
                     S   +   + +       G +  VA  +    P       P  P    T P
Sbjct: 4774 ---WEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAGTEP 4830

Query: 236  PLPPASVLSDK-----AVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPP 290
                A     K        P   P  L      LP     GY  LK++    +   QE P
Sbjct: 4831 KKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLP-----GYT-LKSQLDILSLLKQESP 4884

Query: 291  APPPPLPPYASCSP------RASLPAPPLPGVNSSSETPPPL-PPKSPSFQAPPQKAGAQ 343
            AP PP     + +       + S P P  P    S   P P  PP  P  + P +     
Sbjct: 4885 APEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEP 4944

Query: 344  ALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPP 376
             +P+P     S    + K   RP   G    PP
Sbjct: 4945 PVPSPLPLASSPESARPKPRARPPEEGEDSRPP 4977



 Score = 36.6 bits (83), Expect = 0.052
 Identities = 27/78 (34%), Positives = 34/78 (43%), Gaps = 7/78 (8%)

Query: 6    PPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSAL-LADIQQGT----RLR 60
            PPP    PPP PL   P  PP+ P V   T  L  A+P   S L LA   +      R R
Sbjct: 4909 PPPEEPSPPPSPLAPSPASPPTEPLVELPTEPL--AEPPVPSPLPLASSPESARPKPRAR 4966

Query: 61   KVTQINDRSAPQIESSKG 78
               +  D   P+++  KG
Sbjct: 4967 PPEEGEDSRPPRLKKWKG 4984



 Score = 33.9 bits (76), Expect = 0.34
 Identities = 35/145 (24%), Positives = 53/145 (36%), Gaps = 10/145 (6%)

Query: 218  PVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQL-------APLHLPPIPPPLPLLPPC 270
            P P  P   PPP      P   ASVL +  VKP++       +P       P +   P  
Sbjct: 3091 PGPLGPEERPPPAADASEPRL-ASVLPE--VKPKVEEGGRHPSPCQFTIATPKVEPAPAA 3147

Query: 271  GYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKS 330
               GL  +P      +++      P       + +AS  A   P  +  + +P   P  S
Sbjct: 3148 NSLGLGLKPGQSMMGSRDTRMGTGPFSSSGHTAEKASFGATGGPPAHLLTPSPLSGPGGS 3207

Query: 331  PSFQAPPQKAGAQALPAPPAPPGSQ 355
               +    ++GA  LP  PA  G +
Sbjct: 3208 SLLEKFELESGALTLPGGPAASGDE 3232



 Score = 32.7 bits (73), Expect = 0.75
 Identities = 66/243 (27%), Positives = 79/243 (32%), Gaps = 35/243 (14%)

Query: 7    PPPPLPPPPPPLGAPPP------PPPSAPPVSTDTSS----------LRRADPKGRSALL 50
            PP  L  P    G+ P       PPP A P S D +S           +RA   G   L 
Sbjct: 2752 PPSKLSGPILGPGSFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQ 2811

Query: 51   ADIQQ---------GTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTR-GASTPPTLGD 100
               QQ          T +R        S P  E  +          +TR      P  G 
Sbjct: 2812 QQQQQLWQQQQATAATSMRFAMSARFPSTPGPELGRQALGSPLAGISTRLPGPGEPVPGP 2871

Query: 101  LFAGGFPVLRPAGQRDVAGGKT---GQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSE 157
                 F  LR   Q+ +  G T   GQGP  R   PR    +     + P   R    S 
Sbjct: 2872 AGPAQFIELRHNVQKGLGPGGTPFPGQGPPQR---PRFYPVSEDPHRLAPEGLRGLAVSG 2928

Query: 158  AHGAARTAPPRPNVPAPPPPTPPPPPPPLPP--PLPSSSPIKTPLVSP-PGPLTKGNLPV 214
                  +APP P +     PTP    P LP    L +  P  T L  P P  L  G LP 
Sbjct: 2929 LPPQKPSAPPAPELNNSLHPTPHTKGPTLPTGLELVNRPPSSTELGRPNPLALEAGKLPC 2988

Query: 215  VAP 217
              P
Sbjct: 2989 EDP 2991



 Score = 32.3 bits (72), Expect = 0.99
 Identities = 21/52 (40%), Positives = 24/52 (46%), Gaps = 6/52 (11%)

Query: 2    PVPPPPP---PPLPPPPPPLGAPPPPPPSAPPVSTD---TSSLRRADPKGRS 47
            P PPP P    P  PP  PL   P  P + PPV +     SS   A PK R+
Sbjct: 4914 PSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPRA 4965



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 49/193 (25%), Positives = 65/193 (33%), Gaps = 41/193 (21%)

Query: 197  KTPLVSPPGPLTKGNLPVVAP-PVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPL 255
            K+ LV  P     G  P++ P   P       PPPP TP  +    V S + V    A  
Sbjct: 2745 KSSLVGLPPSKLSG--PILGPGSFPSDDRLSRPPPPATPSSM---DVNSRQLVGGSQAFY 2799

Query: 256  HLPPIPPPLPLLPPCGYPGLKAEPASP-----AQDAQEPPAPPPPLPPYASCSPRASLPA 310
               P P  LPL         + +  +      A  A+ P  P P L   A  SP A +  
Sbjct: 2800 QRAPYPGSLPLQQQQQQLWQQQQATAATSMRFAMSARFPSTPGPELGRQALGSPLAGI-- 2857

Query: 311  PPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAG- 369
                    S+  P P  P                    P P G   F++ + + + G G 
Sbjct: 2858 --------STRLPGPGEPV-------------------PGPAGPAQFIELRHNVQKGLGP 2890

Query: 370  GGKLNPPPAPPAR 382
            GG   P   PP R
Sbjct: 2891 GGTPFPGQGPPQR 2903



 Score = 30.0 bits (66), Expect = 4.9
 Identities = 18/40 (45%), Positives = 18/40 (45%), Gaps = 14/40 (35%)

Query: 203  PPGP------LTKGNLPVVAPPVPCAPPPPPPPPPPTPPP 236
            P GP      LTK NL          PP PP   PPTPPP
Sbjct: 4601 PTGPDYYSQLLTKNNLS--------NPPTPPSSLPPTPPP 4632



 Score = 29.3 bits (64), Expect = 8.3
 Identities = 22/65 (33%), Positives = 27/65 (41%), Gaps = 8/65 (12%)

Query: 1    MPVPPPPPPPLPPPPP----PLGAPPPPPPSAPPVSTDTSSLRRADPKG----RSALLAD 52
            +P  P   PP+P P P    P  A P P    P    D+   R    KG    R  LL  
Sbjct: 4936 LPTEPLAEPPVPSPLPLASSPESARPKPRARPPEEGEDSRPPRLKKWKGVRWKRLRLLLT 4995

Query: 53   IQQGT 57
            IQ+G+
Sbjct: 4996 IQKGS 5000


>gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens]
          Length = 464

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 88/268 (32%), Positives = 103/268 (38%), Gaps = 50/268 (18%)

Query: 126 PGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPP 185
           PG + P P L N       +PP  P             + PP P    P PP PP  P P
Sbjct: 228 PGVKRPPPPLMNG------LPPRPP----------LPESLPPPPPGGLPLPPMPPTGPAP 271

Query: 186 LPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSD 245
             PP P   P   P V PP P+       V PP P   PP P   PP P   PP S +  
Sbjct: 272 SGPPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPTSGVHP 331

Query: 246 KA--VKPQLAPLHLPPIP---PPLP-LLPPCGYPGLKAEPAS----------PAQDAQEP 289
            A  V P    +H PP P   PP P + PP   PG+   P++          PA  A  P
Sbjct: 332 PAPGVHPPAPGVH-PPAPGVHPPAPGVHPPA--PGVHPPPSAGVHPQAPGVHPAAPAVHP 388

Query: 290 PAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPP 349
            AP    PP     P+A    P  PGV+ S+    P PP        P   G    P  P
Sbjct: 389 QAPGVH-PPAPGMHPQAPGVHPQPPGVHPSAPGVHPQPP-----GVHPSNPGVH--PPTP 440

Query: 350 APPGSQPFLQKKRHGRPGAGGGKLNPPP 377
            PP  +P L       P  G G + PPP
Sbjct: 441 MPPMLRPPL-------PSEGPGNIPPPP 461



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 79/237 (33%), Positives = 90/237 (37%), Gaps = 26/237 (10%)

Query: 159 HGAARTAPPRPNVPAPPPPTPPPPPP-----PLPPPLPSSSPIKTPLVSPPGPLTKGNLP 213
           H      P  P++PA PP    PPPP     P  PPLP S P       PPG L    +P
Sbjct: 211 HFKMEKPPAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPESLP-----PPPPGGLPLPPMP 265

Query: 214 VVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKA--VKPQLAPLHLPPIPPPLPLLPPCG 271
              P  P  PP PP  PPP P   PPA V+   A  V P    +H PP P   P  P   
Sbjct: 266 PTGP-APSGPPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAPGVH-PPAPGVHPPAPGVH 323

Query: 272 YPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPP---LPP 328
            P     P +P      PPAP    PP     P A    PP PGV+     PPP   + P
Sbjct: 324 PPTSGVHPPAPGV---HPPAPGVH-PPAPGVHPPAPGVHPPAPGVH-----PPPSAGVHP 374

Query: 329 KSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPT 385
           ++P           QA    P  PG  P         PG         P PP   P+
Sbjct: 375 QAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPGVHPQPPGVHPS 431



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 87/309 (28%), Positives = 98/309 (31%), Gaps = 82/309 (26%)

Query: 5   PPPPPPLPPPPPPLGAPPPP-----------PPSAPPVSTDTSSLRRADPKGRSALLADI 53
           PP PP LP  PP +  PPPP           P S PP       L    P G        
Sbjct: 217 PPAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPTG-------- 268

Query: 54  QQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAG---GFPVLR 110
                           AP                   G   PP L     G     PV+ 
Sbjct: 269 ---------------PAPS------------------GPPGPPQLPPPAPGVHPPAPVVH 295

Query: 111 PAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAH-GAARTAPPRP 169
           P      A G     PG   P+P +          PPA      TS  H  A    PP P
Sbjct: 296 PP-----ASGVHPPAPGVHPPAPGVH---------PPAPGVHPPTSGVHPPAPGVHPPAP 341

Query: 170 NVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPP 229
            V  PP P   PP P + PP P   P  +  V P  P      P V P  P   PP P  
Sbjct: 342 GV-HPPAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGM 400

Query: 230 PPPTP--PPLPPASVLSDKAVKPQLAPLH--LPPIPPPLPLLPPCGYPGLKAEPASPAQD 285
            P  P   P PP    S   V PQ   +H   P + PP P+ P          P  P++ 
Sbjct: 401 HPQAPGVHPQPPGVHPSAPGVHPQPPGVHPSNPGVHPPTPMPP-------MLRPPLPSEG 453

Query: 286 AQEPPAPPP 294
               P PPP
Sbjct: 454 PGNIPPPPP 462



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 73/253 (28%), Positives = 91/253 (35%), Gaps = 34/253 (13%)

Query: 2   PVPP-----PPPPPLP---PPPPPLGAP-PPPPPSAPPVSTDTSSLRRADPKGRSALLAD 52
           P PP     PP PPLP   PPPPP G P PP PP+ P  S      +   P       A 
Sbjct: 233 PPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPAP 292

Query: 53  IQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPA 112
           +           ++  ++     + G +    G         PPT G        V  PA
Sbjct: 293 V-----------VHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPTSG--------VHPPA 333

Query: 113 -GQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNV 171
            G    A G     PG   P+P + +    G   PP++         H AA    P+   
Sbjct: 334 PGVHPPAPGVHPPAPGVHPPAPGV-HPPAPGVHPPPSAGVHPQAPGVHPAAPAVHPQAPG 392

Query: 172 PAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAP---PPPPP 228
             PP P   P  P + P  P   P   P V P  P    + P V PP P  P   PP P 
Sbjct: 393 VHPPAPGMHPQAPGVHPQPPGVHP-SAPGVHPQPPGVHPSNPGVHPPTPMPPMLRPPLPS 451

Query: 229 PPPPTPPPLPPAS 241
             P   PP PP +
Sbjct: 452 EGPGNIPPPPPTN 464



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 69/242 (28%), Positives = 92/242 (38%), Gaps = 28/242 (11%)

Query: 1   MPVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLR 60
           +P  PP P  LPPPPP     PP PP+ P  S      +   P       A +       
Sbjct: 241 LPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPAPV------- 293

Query: 61  KVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPA-GQRDVAG 119
               ++  ++     + G +    G         PPT G +      V  PA G    A 
Sbjct: 294 ----VHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPTSG-VHPPAPGVHPPAPGVHPPAP 348

Query: 120 GKTGQGPGSRAPSPRLPNKTISG-----PLIPPASPRLGNTSEAHGAARTAP-PRPNVPA 173
           G     PG   P+P +     +G     P + PA+P +    +A G    AP   P  P 
Sbjct: 349 GVHPPAPGVHPPAPGVHPPPSAGVHPQAPGVHPAAPAV--HPQAPGVHPPAPGMHPQAPG 406

Query: 174 --PPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP 231
             P PP   P  P + P  P   P   P V PP P+     P++ PP+P   P   PPPP
Sbjct: 407 VHPQPPGVHPSAPGVHPQPPGVHP-SNPGVHPPTPMP----PMLRPPLPSEGPGNIPPPP 461

Query: 232 PT 233
           PT
Sbjct: 462 PT 463



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 47/134 (35%), Positives = 51/134 (38%), Gaps = 28/134 (20%)

Query: 258 PPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPP--LPPYASCSPRASLPAPPLPG 315
           PP PP LP     G PG+K  P  P      PP PP P  LPP     P   LP PP+P 
Sbjct: 217 PPAPPSLP----AGPPGVKRPP--PPLMNGLPPRPPLPESLPP----PPPGGLPLPPMPP 266

Query: 316 VN---SSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGK 372
                S    PP LPP +P    P       A    P  PG  P         PG     
Sbjct: 267 TGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAPGVHP-------PAPGV---- 315

Query: 373 LNPPPAPPARSPTT 386
              PPAP    PT+
Sbjct: 316 --HPPAPGVHPPTS 327


>gi|40807452 peroxisome proliferator-activated receptor gamma,
            coactivator-related 1 [Homo sapiens]
          Length = 1664

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 125/445 (28%), Positives = 164/445 (36%), Gaps = 76/445 (17%)

Query: 3    VPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKV 62
            +PP    P  P P  L    P P    PV       R  DP  R   ++    G+  + +
Sbjct: 653  LPPVDAVPSGPAPVDLALVDPVPNDLTPVDPVLVKSRPTDP--RRGAVSSALGGSAPQLL 710

Query: 63   TQINDRSAPQI------ESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRD 116
             +      P+       E       E G SA T  A   P    L    +   R   Q +
Sbjct: 711  VESESLDPPKTIIPEVKEVVDSLKIESGTSATTHEARPRP----LSLSEYRRRRQQRQAE 766

Query: 117  VAGGKTGQGPGSRAPS-PRLPNKTISGP--LIPPASPRLGNTSEAHGAARTAPPRPN--- 170
                ++ Q P  + PS P  P      P  +IPPA  +         A + +P  P    
Sbjct: 767  TEE-RSPQPPTGKWPSLPETPTGLADIPCLVIPPAPAK-------KTALQRSPETPLEIC 818

Query: 171  -VPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPV--VAPPVPCAP---- 223
             VP  P P  P P PP+  P+ SS   + P    P  L + + PV  V+P VP  P    
Sbjct: 819  LVPVGPSPASPSPEPPVSKPVASSPTEQVPSQEMP-LLARPSPPVQSVSPAVPTPPSMSA 877

Query: 224  -----------PPPPPPPPPTPPPLPPAS--VLSDKAVK----------PQLAPLHLPPI 260
                       PP  PPPP  PP LP +   VL D              P ++P   P +
Sbjct: 878  ALPFPAGGLGMPPSLPPPPLQPPSLPLSMGPVLPDPFTHYAPLPSWPCYPHVSPSGYPCL 937

Query: 261  PPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPP-PLPPYASCSPRASLPAPPLP--GVN 317
            PPP  +    G PG  A P +       P APPP P+ PY+S      L   P P     
Sbjct: 938  PPPPTVPLVSGTPGAYAVPPT----CSVPWAPPPAPVSPYSSTCTYGPLGWGPGPQHAPF 993

Query: 318  SSSETPPPLPPKSPSFQAPPQKAGAQALPAPP---------APPGSQPFLQKKRHGRPGA 368
             S+  PPPLPP S     P  K  ++  PA P         APP S   L    HG P  
Sbjct: 994  WSTVPPPPLPPASIGRAVPQPKMESRGTPAGPPENVLPLSMAPPLS---LGLPGHGAPQT 1050

Query: 369  GGGKLNPPPAPPARSPTTELSSKSQ 393
               K+   P P +  P  ++S+  Q
Sbjct: 1051 EPTKVEVKPVPASPHPKHKVSALVQ 1075



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 103/438 (23%), Positives = 144/438 (32%), Gaps = 71/438 (16%)

Query: 1    MPVPPPPPPPLPPPPPPLGAPP--PPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTR 58
            +P PP     LP P   LG PP  PPPP  PP    +      DP    A L        
Sbjct: 869  VPTPPSMSAALPFPAGGLGMPPSLPPPPLQPPSLPLSMGPVLPDPFTHYAPLPS------ 922

Query: 59   LRKVTQINDRSAPQIESSKGTNKEGGGSANTRGA-STPPTLGDLFAGGFPVLRPAGQRDV 117
                  ++    P +          G    T GA + PPT    +A     + P      
Sbjct: 923  WPCYPHVSPSGYPCLPPPPTVPLVSG----TPGAYAVPPTCSVPWAPPPAPVSPYSS-TC 977

Query: 118  AGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPP 177
              G  G GPG   P       T+  P +PPAS  +G           A P+P + +   P
Sbjct: 978  TYGPLGWGPG---PQHAPFWSTVPPPPLPPAS--IGR----------AVPQPKMESRGTP 1022

Query: 178  TPPPP---PPPLPPPL---------PSSSPIKT---PLVSPPGPLTKGNLPVVAP---PV 219
              PP    P  + PPL         P + P K    P+ + P P  K +  V +P    +
Sbjct: 1023 AGPPENVLPLSMAPPLSLGLPGHGAPQTEPTKVEVKPVPASPHPKHKVSALVQSPQMKAL 1082

Query: 220  PCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIP-----PPLPLLPPCGYPG 274
             C          P    L P +  +    KP L      P P     P LP + P     
Sbjct: 1083 ACVSAEGVTVEEPASERLKPETQETRPREKPPLPATKAVPTPRQSTVPKLPAVHPARLRK 1142

Query: 275  LKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQ 334
            L   P    Q +++       +  + S     +     L      SE     PP +P+  
Sbjct: 1143 LSFLPTPRTQGSED------VVQAFISEIGIEASDLSSLLEQFEKSEAKKECPPPAPADS 1196

Query: 335  APPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPAR--SPTTELS--- 389
                 +G   +P    P         +      A    L PP  PP +   P   +S   
Sbjct: 1197 LAVGNSGGVDIPQEKRP-------LDRLQAPELANVAGLTPPATPPHQLWKPLAAVSLLA 1249

Query: 390  -SKSQQATAWTPTQQPGG 406
             +KS ++TA   T +P G
Sbjct: 1250 KAKSPKSTAQEGTLKPEG 1267



 Score = 32.7 bits (73), Expect = 0.75
 Identities = 42/173 (24%), Positives = 62/173 (35%), Gaps = 32/173 (18%)

Query: 233  TPPPLPPASVL------------SDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPA 280
            TPP   PA V+             D  +KP L+   L P  PP    PPC       EP 
Sbjct: 1304 TPPKKMPALVIPEVGSRWNVKRHQDITIKPVLS---LGPAAPP----PPC--IAASREPL 1354

Query: 281  SPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKA 340
                 +++     P L P +  SP AS      P  N  +   PP P          +KA
Sbjct: 1355 DHRTSSEQADPSAPCLAPSSLLSPEAS------PCRNDMNTRTPPEPSAKQRSMRCYRKA 1408

Query: 341  GAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQ 393
               A P+     G     ++ R+ R  + G       +  + S ++   S+S+
Sbjct: 1409 CRSASPSSQGWQG-----RRGRNSRSVSSGSNRTSEASSSSSSSSSSSRSRSR 1456


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 136/509 (26%), Positives = 176/509 (34%), Gaps = 101/509 (19%)

Query: 27  SAPPVSTDTSSLRRADPKGRSALLADIQQGTRLR-KVTQINDRSAPQIESSKGTNKEGGG 85
           SA  V  + SS  +++ + R  + +D ++  R   K T+  + S P   S          
Sbjct: 78  SAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSR 137

Query: 86  SANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPL- 144
           S N  G+S P  +        P +      +     + Q    +A  P L   T   P  
Sbjct: 138 SVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAP 197

Query: 145 --IPPASPRL---GNTSEAHGA-------ARTAPPRPNVPAPPPPT----------PPPP 182
              PP +P+L   G T  A          A  AP +P  P  P P           P  P
Sbjct: 198 SSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRP 257

Query: 183 PPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPP-----------PPP 231
           P P PPP PS  P   PL    G   + + P  A P      PP P           P P
Sbjct: 258 PSPHPPPHPSPHPPLQPLTGSAG---QPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGP 314

Query: 232 PTPPPLPPASVLSDKAV--KPQLAPLHL---------------PPIPPPLPLLPPCGYPG 274
           P P  LPP +      +   P  A  H                PP   PLP  P    P 
Sbjct: 315 PQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAP-LAMPH 373

Query: 275 LKAEPASPAQDAQEPPAP--PPPLPPYASCSPRASLPAPPLPGVNSSSET-------PPP 325
           +K  P +P      P A   PP L   +  S  A+LP PP     SS  T       PPP
Sbjct: 374 IKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPP 433

Query: 326 L---PPKSPSFQAPPQKAG---AQALPAPPA--PP-------GSQPFLQKKRHGRPGAGG 370
           L   P   P   +P Q  G   +Q LP PPA  PP          PF Q      P   G
Sbjct: 434 LQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQ-----HPFVPG 488

Query: 371 GKLNPPPAPPARSPTTELSSKSQQATAWTP---TQQPGGQLRNGSLHIIDDFESKFTFHS 427
           G   PPP  P   P+T         +A  P       GG +  GS   +   + K    +
Sbjct: 489 G---PPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIK--EEA 543

Query: 428 VEDFPPPDEYKPCQKIYPSKIPRSRTPGP 456
           ++D   P+         P   PRS +P P
Sbjct: 544 LDDAEEPES--------PPPPPRSPSPEP 564



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 121/450 (26%), Positives = 165/450 (36%), Gaps = 100/450 (22%)

Query: 21  PPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSAPQIESSKGTN 80
           P  P     P++ D  S  R  P   S    D +  T  +   ++ + ++  ++S+K   
Sbjct: 38  PASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQR 97

Query: 81  KEGGGSANT--RGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNK 138
           ++         R +S      ++     P     G+ + +  ++    GS  P     + 
Sbjct: 98  EKVASDTEEADRTSSKKTKTQEISRPNSP---SEGEGESSDSRSVNDEGSSDPKDIDQDN 154

Query: 139 TISGPLIPPASPRLGNTSEAHGAAR-----TAPPRPNVPA---PPPPTPPPPPPPLPPPL 190
             + P IP  SP+  N S++  +A+       PP    P    P P + PP  P LP P 
Sbjct: 155 RSTSPSIP--SPQ-DNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPG 211

Query: 191 PSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPP-------------------PPPPPP 231
           P+ S    P   P G  T    P   P  P AP P                   PPP P 
Sbjct: 212 PTPSATAVP---PQGSPTASQAPN-QPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPS 267

Query: 232 PTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPA 291
           P PP  P    L+  A +P  AP H     PPL    P G   L+A P        + P 
Sbjct: 268 PHPPLQP----LTGSAGQPS-APSH---AQPPLHGQGPPGPHSLQAGP------LLQHPG 313

Query: 292 PPPP--LPPYAS-------CSPRASLP--APPLPGVNSS--SETPP---PLPP------- 328
           PP P  LPP AS        SP A+ P  +  LP   S+  S+ PP   PLPP       
Sbjct: 314 PPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPH 373

Query: 329 -KSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPA--------- 378
            K P     PQ    QA   PP   G  PF          +    L PPPA         
Sbjct: 374 IKPPPTTPIPQLPAPQAHKHPPHLSGPSPF----------SMNANLPPPPALKPLSSLST 423

Query: 379 ---PPARSPTTELSSKSQQATAWTPTQQPG 405
              P A  P  +L  +SQ   + +P Q PG
Sbjct: 424 HHPPSAHPPPLQLMPQSQPLPS-SPAQPPG 452



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 115/411 (27%), Positives = 143/411 (34%), Gaps = 67/411 (16%)

Query: 2   PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALL--ADIQQGTRL 59
           P P   PP  P  P P   P P   + PP  + T+S     P+  +A +    IQQ   L
Sbjct: 195 PAPSSAPPGTPQLPTP--GPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPAL 252

Query: 60  RKVTQINDRSAPQIESSKGTNKEGG--GSANTRGASTPPTLGDLFAGGFPVLRPAGQRDV 117
                 +    P            G  G  +    + PP  G           P G   +
Sbjct: 253 HPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQ---------GPPGPHSL 303

Query: 118 AGGKTGQGPGSRAPSPRLPNKTISG--PLIPPASPRLGNTSEAHGAARTA-----PPRPN 170
             G   Q PG   P   LP +   G  PL    +    +TS    A+++A     PPR  
Sbjct: 304 QAGPLLQHPGPPQPF-GLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQ 362

Query: 171 VPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPP 230
              P PP P   P   PPP        TP+   P P    + P ++ P P +     PP 
Sbjct: 363 ---PLPPAPLAMPHIKPPP-------TTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPP- 411

Query: 231 PPTPPPLPPASVLSDKAVKPQLAPLHLPPI--PPPLPLLPPCGYPGLKAEPASPAQDAQE 288
              PP L P S LS           H PP   PPPL L+P      L + PA P    Q 
Sbjct: 412 ---PPALKPLSSLS----------THHPPSAHPPPLQLMPQS--QPLPSSPAQPPGLTQS 456

Query: 289 PPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPL-PPKSPSFQAPPQKAGAQALP- 346
              PPPP   +         P PP          PPP+ PP  PS   PP   G  A P 
Sbjct: 457 QNLPPPP-ASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPP 515

Query: 347 --APPAPPGS--------QPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTE 387
                A  GS         P +Q K      A   +    P PP RSP+ E
Sbjct: 516 CSGAAASGGSIAGGSSCPLPTVQIKEEALDDA---EEPESPPPPPRSPSPE 563



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 75/299 (25%), Positives = 101/299 (33%), Gaps = 74/299 (24%)

Query: 5   PPPPPPL--------PPPPPPLGAPPPPPPSAPPVSTDTSSLRRAD----PKGRSALLAD 52
           PP P  L        P PP P G PP       P+ T  ++         P  +SAL + 
Sbjct: 297 PPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQS- 355

Query: 53  IQQGTRLRKV---------------TQINDRSAPQIESSKGTNKEGGGSANTRGASTPPT 97
            QQ  R + +               T I    APQ  + K      G S  +  A+ PP 
Sbjct: 356 -QQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQ--AHKHPPHLSGPSPFSMNANLPPP 412

Query: 98  LGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSE 157
                    P L+P     ++   T   P +  P  +L  ++   P  P   P L  +  
Sbjct: 413 ---------PALKP-----LSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQN 458

Query: 158 AHGAARTAPP--------------RPNVPAPPPPTPPP--PPPPLPPPLPSSS--PIKTP 199
                 + PP               P VP  PPP  PP  P    PP  P +S  P  + 
Sbjct: 459 LPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSG 518

Query: 200 LVSPPGPLTKGN---LPVVA--------PPVPCAPPPPPPPPPPTPPPLPPASVLSDKA 247
             +  G +  G+   LP V            P +PPPPP  P P P  +   S  S  A
Sbjct: 519 AAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSA 577


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 136/509 (26%), Positives = 176/509 (34%), Gaps = 101/509 (19%)

Query: 27   SAPPVSTDTSSLRRADPKGRSALLADIQQGTRLR-KVTQINDRSAPQIESSKGTNKEGGG 85
            SA  V  + SS  +++ + R  + +D ++  R   K T+  + S P   S          
Sbjct: 632  SAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSR 691

Query: 86   SANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPL- 144
            S N  G+S P  +        P +      +     + Q    +A  P L   T   P  
Sbjct: 692  SVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAP 751

Query: 145  --IPPASPRL---GNTSEAHGA-------ARTAPPRPNVPAPPPPT----------PPPP 182
               PP +P+L   G T  A          A  AP +P  P  P P           P  P
Sbjct: 752  SSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRP 811

Query: 183  PPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPP-----------PPP 231
            P P PPP PS  P   PL    G   + + P  A P      PP P           P P
Sbjct: 812  PSPHPPPHPSPHPPLQPLTGSAG---QPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGP 868

Query: 232  PTPPPLPPASVLSDKAV--KPQLAPLHL---------------PPIPPPLPLLPPCGYPG 274
            P P  LPP +      +   P  A  H                PP   PLP  P    P 
Sbjct: 869  PQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAP-LAMPH 927

Query: 275  LKAEPASPAQDAQEPPAP--PPPLPPYASCSPRASLPAPPLPGVNSSSET-------PPP 325
            +K  P +P      P A   PP L   +  S  A+LP PP     SS  T       PPP
Sbjct: 928  IKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPP 987

Query: 326  L---PPKSPSFQAPPQKAG---AQALPAPPA--PP-------GSQPFLQKKRHGRPGAGG 370
            L   P   P   +P Q  G   +Q LP PPA  PP          PF Q      P   G
Sbjct: 988  LQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQ-----HPFVPG 1042

Query: 371  GKLNPPPAPPARSPTTELSSKSQQATAWTP---TQQPGGQLRNGSLHIIDDFESKFTFHS 427
            G   PPP  P   P+T         +A  P       GG +  GS   +   + K    +
Sbjct: 1043 G---PPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIK--EEA 1097

Query: 428  VEDFPPPDEYKPCQKIYPSKIPRSRTPGP 456
            ++D   P+         P   PRS +P P
Sbjct: 1098 LDDAEEPES--------PPPPPRSPSPEP 1118



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 121/450 (26%), Positives = 165/450 (36%), Gaps = 100/450 (22%)

Query: 21   PPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSAPQIESSKGTN 80
            P  P     P++ D  S  R  P   S    D +  T  +   ++ + ++  ++S+K   
Sbjct: 592  PASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQR 651

Query: 81   KEGGGSANT--RGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNK 138
            ++         R +S      ++     P     G+ + +  ++    GS  P     + 
Sbjct: 652  EKVASDTEEADRTSSKKTKTQEISRPNSP---SEGEGESSDSRSVNDEGSSDPKDIDQDN 708

Query: 139  TISGPLIPPASPRLGNTSEAHGAAR-----TAPPRPNVPA---PPPPTPPPPPPPLPPPL 190
              + P IP  SP+  N S++  +A+       PP    P    P P + PP  P LP P 
Sbjct: 709  RSTSPSIP--SPQ-DNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPG 765

Query: 191  PSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPP-------------------PPPPPP 231
            P+ S    P   P G  T    P   P  P AP P                   PPP P 
Sbjct: 766  PTPSATAVP---PQGSPTASQAPN-QPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPS 821

Query: 232  PTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPA 291
            P PP  P    L+  A +P  AP H     PPL    P G   L+A P        + P 
Sbjct: 822  PHPPLQP----LTGSAGQPS-APSH---AQPPLHGQGPPGPHSLQAGP------LLQHPG 867

Query: 292  PPPP--LPPYAS-------CSPRASLP--APPLPGVNSS--SETPP---PLPP------- 328
            PP P  LPP AS        SP A+ P  +  LP   S+  S+ PP   PLPP       
Sbjct: 868  PPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPH 927

Query: 329  -KSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPA--------- 378
             K P     PQ    QA   PP   G  PF          +    L PPPA         
Sbjct: 928  IKPPPTTPIPQLPAPQAHKHPPHLSGPSPF----------SMNANLPPPPALKPLSSLST 977

Query: 379  ---PPARSPTTELSSKSQQATAWTPTQQPG 405
               P A  P  +L  +SQ   + +P Q PG
Sbjct: 978  HHPPSAHPPPLQLMPQSQPLPS-SPAQPPG 1006



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 115/411 (27%), Positives = 143/411 (34%), Gaps = 67/411 (16%)

Query: 2    PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALL--ADIQQGTRL 59
            P P   PP  P  P P   P P   + PP  + T+S     P+  +A +    IQQ   L
Sbjct: 749  PAPSSAPPGTPQLPTP--GPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPAL 806

Query: 60   RKVTQINDRSAPQIESSKGTNKEGG--GSANTRGASTPPTLGDLFAGGFPVLRPAGQRDV 117
                  +    P            G  G  +    + PP  G           P G   +
Sbjct: 807  HPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQ---------GPPGPHSL 857

Query: 118  AGGKTGQGPGSRAPSPRLPNKTISG--PLIPPASPRLGNTSEAHGAARTA-----PPRPN 170
              G   Q PG   P   LP +   G  PL    +    +TS    A+++A     PPR  
Sbjct: 858  QAGPLLQHPGPPQPF-GLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQ 916

Query: 171  VPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPP 230
               P PP P   P   PPP        TP+   P P    + P ++ P P +     PP 
Sbjct: 917  ---PLPPAPLAMPHIKPPP-------TTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPP- 965

Query: 231  PPTPPPLPPASVLSDKAVKPQLAPLHLPPI--PPPLPLLPPCGYPGLKAEPASPAQDAQE 288
               PP L P S LS           H PP   PPPL L+P      L + PA P    Q 
Sbjct: 966  ---PPALKPLSSLS----------THHPPSAHPPPLQLMPQS--QPLPSSPAQPPGLTQS 1010

Query: 289  PPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPL-PPKSPSFQAPPQKAGAQALP- 346
               PPPP   +         P PP          PPP+ PP  PS   PP   G  A P 
Sbjct: 1011 QNLPPPP-ASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPP 1069

Query: 347  --APPAPPGS--------QPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTE 387
                 A  GS         P +Q K      A   +    P PP RSP+ E
Sbjct: 1070 CSGAAASGGSIAGGSSCPLPTVQIKEEALDDA---EEPESPPPPPRSPSPE 1117



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 75/299 (25%), Positives = 101/299 (33%), Gaps = 74/299 (24%)

Query: 5    PPPPPPL--------PPPPPPLGAPPPPPPSAPPVSTDTSSLRRAD----PKGRSALLAD 52
            PP P  L        P PP P G PP       P+ T  ++         P  +SAL + 
Sbjct: 851  PPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQS- 909

Query: 53   IQQGTRLRKV---------------TQINDRSAPQIESSKGTNKEGGGSANTRGASTPPT 97
             QQ  R + +               T I    APQ  + K      G S  +  A+ PP 
Sbjct: 910  -QQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQ--AHKHPPHLSGPSPFSMNANLPPP 966

Query: 98   LGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSE 157
                     P L+P     ++   T   P +  P  +L  ++   P  P   P L  +  
Sbjct: 967  ---------PALKP-----LSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQN 1012

Query: 158  AHGAARTAPP--------------RPNVPAPPPPTPPP--PPPPLPPPLPSSS--PIKTP 199
                  + PP               P VP  PPP  PP  P    PP  P +S  P  + 
Sbjct: 1013 LPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSG 1072

Query: 200  LVSPPGPLTKGN---LPVVA--------PPVPCAPPPPPPPPPPTPPPLPPASVLSDKA 247
              +  G +  G+   LP V            P +PPPPP  P P P  +   S  S  A
Sbjct: 1073 AAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSA 1131


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 136/509 (26%), Positives = 176/509 (34%), Gaps = 101/509 (19%)

Query: 27   SAPPVSTDTSSLRRADPKGRSALLADIQQGTRLR-KVTQINDRSAPQIESSKGTNKEGGG 85
            SA  V  + SS  +++ + R  + +D ++  R   K T+  + S P   S          
Sbjct: 632  SAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSR 691

Query: 86   SANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPL- 144
            S N  G+S P  +        P +      +     + Q    +A  P L   T   P  
Sbjct: 692  SVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAP 751

Query: 145  --IPPASPRL---GNTSEAHGA-------ARTAPPRPNVPAPPPPT----------PPPP 182
               PP +P+L   G T  A          A  AP +P  P  P P           P  P
Sbjct: 752  SSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRP 811

Query: 183  PPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPP-----------PPP 231
            P P PPP PS  P   PL    G   + + P  A P      PP P           P P
Sbjct: 812  PSPHPPPHPSPHPPLQPLTGSAG---QPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGP 868

Query: 232  PTPPPLPPASVLSDKAV--KPQLAPLHL---------------PPIPPPLPLLPPCGYPG 274
            P P  LPP +      +   P  A  H                PP   PLP  P    P 
Sbjct: 869  PQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAP-LAMPH 927

Query: 275  LKAEPASPAQDAQEPPAP--PPPLPPYASCSPRASLPAPPLPGVNSSSET-------PPP 325
            +K  P +P      P A   PP L   +  S  A+LP PP     SS  T       PPP
Sbjct: 928  IKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPP 987

Query: 326  L---PPKSPSFQAPPQKAG---AQALPAPPA--PP-------GSQPFLQKKRHGRPGAGG 370
            L   P   P   +P Q  G   +Q LP PPA  PP          PF Q      P   G
Sbjct: 988  LQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQ-----HPFVPG 1042

Query: 371  GKLNPPPAPPARSPTTELSSKSQQATAWTP---TQQPGGQLRNGSLHIIDDFESKFTFHS 427
            G   PPP  P   P+T         +A  P       GG +  GS   +   + K    +
Sbjct: 1043 G---PPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIK--EEA 1097

Query: 428  VEDFPPPDEYKPCQKIYPSKIPRSRTPGP 456
            ++D   P+         P   PRS +P P
Sbjct: 1098 LDDAEEPES--------PPPPPRSPSPEP 1118



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 121/450 (26%), Positives = 165/450 (36%), Gaps = 100/450 (22%)

Query: 21   PPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSAPQIESSKGTN 80
            P  P     P++ D  S  R  P   S    D +  T  +   ++ + ++  ++S+K   
Sbjct: 592  PASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQR 651

Query: 81   KEGGGSANT--RGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNK 138
            ++         R +S      ++     P     G+ + +  ++    GS  P     + 
Sbjct: 652  EKVASDTEEADRTSSKKTKTQEISRPNSP---SEGEGESSDSRSVNDEGSSDPKDIDQDN 708

Query: 139  TISGPLIPPASPRLGNTSEAHGAAR-----TAPPRPNVPA---PPPPTPPPPPPPLPPPL 190
              + P IP  SP+  N S++  +A+       PP    P    P P + PP  P LP P 
Sbjct: 709  RSTSPSIP--SPQ-DNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPG 765

Query: 191  PSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPP-------------------PPPPPP 231
            P+ S    P   P G  T    P   P  P AP P                   PPP P 
Sbjct: 766  PTPSATAVP---PQGSPTASQAPN-QPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPS 821

Query: 232  PTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPA 291
            P PP  P    L+  A +P  AP H     PPL    P G   L+A P        + P 
Sbjct: 822  PHPPLQP----LTGSAGQPS-APSH---AQPPLHGQGPPGPHSLQAGP------LLQHPG 867

Query: 292  PPPP--LPPYAS-------CSPRASLP--APPLPGVNSS--SETPP---PLPP------- 328
            PP P  LPP AS        SP A+ P  +  LP   S+  S+ PP   PLPP       
Sbjct: 868  PPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPH 927

Query: 329  -KSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPA--------- 378
             K P     PQ    QA   PP   G  PF          +    L PPPA         
Sbjct: 928  IKPPPTTPIPQLPAPQAHKHPPHLSGPSPF----------SMNANLPPPPALKPLSSLST 977

Query: 379  ---PPARSPTTELSSKSQQATAWTPTQQPG 405
               P A  P  +L  +SQ   + +P Q PG
Sbjct: 978  HHPPSAHPPPLQLMPQSQPLPS-SPAQPPG 1006



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 115/411 (27%), Positives = 143/411 (34%), Gaps = 67/411 (16%)

Query: 2    PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALL--ADIQQGTRL 59
            P P   PP  P  P P   P P   + PP  + T+S     P+  +A +    IQQ   L
Sbjct: 749  PAPSSAPPGTPQLPTP--GPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPAL 806

Query: 60   RKVTQINDRSAPQIESSKGTNKEGG--GSANTRGASTPPTLGDLFAGGFPVLRPAGQRDV 117
                  +    P            G  G  +    + PP  G           P G   +
Sbjct: 807  HPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQ---------GPPGPHSL 857

Query: 118  AGGKTGQGPGSRAPSPRLPNKTISG--PLIPPASPRLGNTSEAHGAARTA-----PPRPN 170
              G   Q PG   P   LP +   G  PL    +    +TS    A+++A     PPR  
Sbjct: 858  QAGPLLQHPGPPQPF-GLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQ 916

Query: 171  VPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPP 230
               P PP P   P   PPP        TP+   P P    + P ++ P P +     PP 
Sbjct: 917  ---PLPPAPLAMPHIKPPP-------TTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPP- 965

Query: 231  PPTPPPLPPASVLSDKAVKPQLAPLHLPPI--PPPLPLLPPCGYPGLKAEPASPAQDAQE 288
               PP L P S LS           H PP   PPPL L+P      L + PA P    Q 
Sbjct: 966  ---PPALKPLSSLS----------THHPPSAHPPPLQLMPQS--QPLPSSPAQPPGLTQS 1010

Query: 289  PPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPL-PPKSPSFQAPPQKAGAQALP- 346
               PPPP   +         P PP          PPP+ PP  PS   PP   G  A P 
Sbjct: 1011 QNLPPPP-ASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPP 1069

Query: 347  --APPAPPGS--------QPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTE 387
                 A  GS         P +Q K      A   +    P PP RSP+ E
Sbjct: 1070 CSGAAASGGSIAGGSSCPLPTVQIKEEALDDA---EEPESPPPPPRSPSPE 1117



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 75/299 (25%), Positives = 101/299 (33%), Gaps = 74/299 (24%)

Query: 5    PPPPPPL--------PPPPPPLGAPPPPPPSAPPVSTDTSSLRRAD----PKGRSALLAD 52
            PP P  L        P PP P G PP       P+ T  ++         P  +SAL + 
Sbjct: 851  PPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQS- 909

Query: 53   IQQGTRLRKV---------------TQINDRSAPQIESSKGTNKEGGGSANTRGASTPPT 97
             QQ  R + +               T I    APQ  + K      G S  +  A+ PP 
Sbjct: 910  -QQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQ--AHKHPPHLSGPSPFSMNANLPPP 966

Query: 98   LGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSE 157
                     P L+P     ++   T   P +  P  +L  ++   P  P   P L  +  
Sbjct: 967  ---------PALKP-----LSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQN 1012

Query: 158  AHGAARTAPP--------------RPNVPAPPPPTPPP--PPPPLPPPLPSSS--PIKTP 199
                  + PP               P VP  PPP  PP  P    PP  P +S  P  + 
Sbjct: 1013 LPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSG 1072

Query: 200  LVSPPGPLTKGN---LPVVA--------PPVPCAPPPPPPPPPPTPPPLPPASVLSDKA 247
              +  G +  G+   LP V            P +PPPPP  P P P  +   S  S  A
Sbjct: 1073 AAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSA 1131


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.135    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,956,612
Number of Sequences: 37866
Number of extensions: 3858882
Number of successful extensions: 206844
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2009
Number of HSP's successfully gapped in prelim test: 2249
Number of HSP's that attempted gapping in prelim test: 25804
Number of HSP's gapped (non-prelim): 62203
length of query: 483
length of database: 18,247,518
effective HSP length: 106
effective length of query: 377
effective length of database: 14,233,722
effective search space: 5366113194
effective search space used: 5366113194
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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