BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|32526901 intraflagellar transport 81-like isoform 1 [Homo sapiens] (676 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|219555661 intraflagellar transport 81-like isoform 1 [Homo sa... 1308 0.0 gi|32526901 intraflagellar transport 81-like isoform 1 [Homo sap... 1308 0.0 gi|34147403 intraflagellar transport 81-like isoform 2 [Homo sap... 764 0.0 gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 103 4e-22 gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 91 3e-18 gi|71061468 centromere protein E [Homo sapiens] 90 6e-18 gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 89 1e-17 gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 89 2e-17 gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 88 2e-17 gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 88 2e-17 gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 87 5e-17 gi|148746195 trichohyalin [Homo sapiens] 87 7e-17 gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 86 1e-16 gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 83 7e-16 gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 83 7e-16 gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 83 9e-16 gi|109255234 centrosomal protein 290kDa [Homo sapiens] 82 1e-15 gi|34577114 cytomatrix protein p110 [Homo sapiens] 82 2e-15 gi|58530840 desmoplakin isoform I [Homo sapiens] 82 2e-15 gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 81 3e-15 gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 81 3e-15 gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 81 4e-15 gi|41872583 Rho-associated, coiled-coil containing protein kinas... 81 4e-15 gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 81 4e-15 gi|221219020 NYD-SP11 protein [Homo sapiens] 80 6e-15 gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 80 8e-15 gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 80 8e-15 gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 80 8e-15 gi|38044112 restin isoform b [Homo sapiens] 79 1e-14 gi|4506751 restin isoform a [Homo sapiens] 79 1e-14 >gi|219555661 intraflagellar transport 81-like isoform 1 [Homo sapiens] Length = 676 Score = 1308 bits (3384), Expect = 0.0 Identities = 676/676 (100%), Positives = 676/676 (100%) Query: 1 MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60 MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ Sbjct: 1 MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60 Query: 61 TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120 TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR Sbjct: 61 TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120 Query: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE Sbjct: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180 Query: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL Sbjct: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240 Query: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS Sbjct: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300 Query: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE Sbjct: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360 Query: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAE 420 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAE Sbjct: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAE 420 Query: 421 LKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKG 480 LKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKG Sbjct: 421 LKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKG 480 Query: 481 RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE 540 RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE Sbjct: 481 RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE 540 Query: 541 SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI 600 SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI Sbjct: 541 SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI 600 Query: 601 REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQT 660 REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQT Sbjct: 601 REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQT 660 Query: 661 SIGQVIQEGGEDRLIL 676 SIGQVIQEGGEDRLIL Sbjct: 661 SIGQVIQEGGEDRLIL 676 >gi|32526901 intraflagellar transport 81-like isoform 1 [Homo sapiens] Length = 676 Score = 1308 bits (3384), Expect = 0.0 Identities = 676/676 (100%), Positives = 676/676 (100%) Query: 1 MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60 MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ Sbjct: 1 MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60 Query: 61 TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120 TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR Sbjct: 61 TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120 Query: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE Sbjct: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180 Query: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL Sbjct: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240 Query: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS Sbjct: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300 Query: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE Sbjct: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360 Query: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAE 420 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAE Sbjct: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAE 420 Query: 421 LKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKG 480 LKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKG Sbjct: 421 LKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKG 480 Query: 481 RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE 540 RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE Sbjct: 481 RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE 540 Query: 541 SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI 600 SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI Sbjct: 541 SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI 600 Query: 601 REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQT 660 REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQT Sbjct: 601 REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQT 660 Query: 661 SIGQVIQEGGEDRLIL 676 SIGQVIQEGGEDRLIL Sbjct: 661 SIGQVIQEGGEDRLIL 676 >gi|34147403 intraflagellar transport 81-like isoform 2 [Homo sapiens] Length = 431 Score = 764 bits (1974), Expect = 0.0 Identities = 396/396 (100%), Positives = 396/396 (100%) Query: 1 MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60 MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ Sbjct: 1 MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60 Query: 61 TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120 TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR Sbjct: 61 TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120 Query: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE Sbjct: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180 Query: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL Sbjct: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240 Query: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS Sbjct: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300 Query: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE Sbjct: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360 Query: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDE 396 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDE Sbjct: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDE 396 Score = 37.4 bits (85), Expect = 0.046 Identities = 48/224 (21%), Positives = 101/224 (45%), Gaps = 38/224 (16%) Query: 407 KSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTME---EKKGISGYSYTQE 463 K + + I E+ +EF L T +++E + + +T+ E+ ISG+S T E Sbjct: 113 KKRAYLARFLIKLEVPSEF-LQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFS-TAE 170 Query: 464 ELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQ 523 + +SA++ E D++ R E +KK ++ + + ++LR +++ + L Q Sbjct: 171 IRKDISAMEEEKDQLIKRV-----EHLKKRVE-TAQNHQWMLKIARQLRVEKEREEYLAQ 224 Query: 524 ECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATD 583 + E+K+Q L+ +++ +++ +R+ + E ++R + Sbjct: 225 QKQEQKNQLFHAVQRLQ----RVQNQLKSMRQAAADAKP------------ESLMKRLEE 268 Query: 584 EMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRE 627 E+K + + E++ K E EN K+L QKV+ E Sbjct: 269 EIKFNL--------YMVTEKFPK---ELENKKKELHFLQKVVSE 301 >gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] Length = 1417 Score = 103 bits (258), Expect = 4e-22 Identities = 120/559 (21%), Positives = 258/559 (46%), Gaps = 64/559 (11%) Query: 141 NKQYEELMEAFKTLHKEY-EQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETA 199 N ++E++ AF+ K + EQ K E+ K I +E QL K+ + K++ +T Sbjct: 742 NTEHEKICLAFEKAKKIHLEQHK-------EMEKQIERLEA---QLEKKDQQFKEQEKTM 791 Query: 200 QNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKP 259 Q + I +Q +E + L + K E K + + L+ +QNQ+ + + Sbjct: 792 SMLQQDI-ICKQHHLES-LDRLLTESKGEMKKENMKKDEALKALQNQVSE--ETIKVRQL 847 Query: 260 ESLMKRLEEEIKFNLYMVT---EKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKI 316 +S ++ +EE+ +L + EKF K+L+ K +E++ LQK + + E + Sbjct: 848 DSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVIL 907 Query: 317 NEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIIS----RKKEAKAEELQEAKEKLASL 372 + Q+++++ +RN +E + +Q S + +++E+ AE+L++ +EK S Sbjct: 908 QHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESA 967 Query: 373 EREASVKRNQTREFDGTE---VLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQ 429 EA +KR + E GT ++ D++K ++K+ + K+ E KA L Sbjct: 968 AHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD----GENKAMH--LS 1021 Query: 430 RTEELLKQRHENIQQQLQTMEEKKGISGYSYTQ--EELERVSALKSEVDEMKG------R 481 + + +L Q ++++ ++E + + + T+ E L++ L++E+ G R Sbjct: 1022 QLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLR 1081 Query: 482 TLDDMSEMVKKLYSLVSEKKSALASVIKELR----QLRQKYQELTQ----------ECDE 527 L ++ ++++K + EK + + + ELR ++ K QEL + E + Sbjct: 1082 QLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQ 1141 Query: 528 KKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEM-- 585 + +Q + +R ++EQ++ +L + E N I++L +L+ A +++ Sbjct: 1142 RAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLRE 1201 Query: 586 KAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQL 645 K +I +++ +++ E E ++++E + V++E Q K DL Q Sbjct: 1202 KEFIMLQNEQEISQLKK-------EIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQE 1254 Query: 646 MECKKQCFLKQQSQTSIGQ 664 + ++ Q S T + + Sbjct: 1255 LRLTRE--QVQNSHTELAE 1271 Score = 77.8 bits (190), Expect = 3e-14 Identities = 146/703 (20%), Positives = 277/703 (39%), Gaps = 134/703 (19%) Query: 35 LQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLL----GILKYKP-------SGNATDM 83 LQ L + L+ + P + D P ++ K +L + G+L Y P SG++TD Sbjct: 154 LQSLGEELSSVSPSENSDYAPN-PSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDF 212 Query: 84 STFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQ 143 + + S + + L ++ N+L+++ A Q Sbjct: 213 QKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQN---------------------ACLVTQ 251 Query: 144 YEELMEAFKTLHKEYEQ--LKISGFSTAE--------IRKDISAMEEE---KDQLIKRVE 190 LM F+++H E Q K+S +A+ + + I +E E +D++++ E Sbjct: 252 NHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAE 311 Query: 191 H-----LKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQN 245 + K +E Q+ Q + +L+V+ + ++ + Q+N+ + + L + Sbjct: 312 NKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQ 371 Query: 246 QLKSMRQAAADAKPESLMK-RLEEEIKFNLYMVTEKFPKELENK----KKELHF----LQ 296 Q K E L K + EEEI EK K L+ + K EL L+ Sbjct: 372 QYKK-------KVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLR 424 Query: 297 KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKE 356 ++ E G L + K +E+ ++ + + + +E K + R + S+++ +E Sbjct: 425 QLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRE 484 Query: 357 AKA-------------EELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNK 403 K +E++ ++ +L SLE+ S + F L + + NK Sbjct: 485 LKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNK 544 Query: 404 LRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHEN-----IQQQLQTMEEKKGISGY 458 + +I+EL+ + + E +++ H N + Q L T + Sbjct: 545 EDRCIGCCEANKLVISELRIKLAI---KEAEIQKLHANLTANQLSQSLITCND------- 594 Query: 459 SYTQEELERVSALKSEVDEMKGRTL-----DDMSEMVKKLYSLVSEKKSALASVIKELR- 512 +E ++S+L++E ++ G + D + K Y +++ L + I+ELR Sbjct: 595 ---SQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQY---EKERQRLVTGIEELRT 648 Query: 513 ---QLRQKYQELTQECDEKKSQYDSCAAGL---ESNRSKLEQEVRRLREECLQ-----EE 561 Q+ + +L + SQ+ L SN SKLE E+ + + L EE Sbjct: 649 KLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEE 708 Query: 562 SRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREK 621 Y++ KN E++ + EK + IR T E E + + Sbjct: 709 KIVAYSSIAAKNAELE-------------QELMEKNEKIRSLETNINTEHEKICLAFEKA 755 Query: 622 QKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQ 664 +K+ E H KQ + LE +E K Q F +Q+ S+ Q Sbjct: 756 KKIHLEQHKEMEKQIER---LEAQLEKKDQQFKEQEKTMSMLQ 795 Score = 68.9 bits (167), Expect = 1e-11 Identities = 106/541 (19%), Positives = 236/541 (43%), Gaps = 49/541 (9%) Query: 133 QDETVADTNKQYEELMEAFKTLHKEYEQLKIS----GFSTAEIRKDISAMEEEKDQLIKR 188 Q+E + ++ E ++L K QL + GF + + +S+ ++D+ I Sbjct: 492 QNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGC 551 Query: 189 VEHLKK-----RVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL--- 240 E K R++ A + K+ L + + + ++ ++L Sbjct: 552 CEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKL 611 Query: 241 --QRVQNQLKSMRQAAADAKPESLMKRLE---EEIKFNLYMVTEKFPKELENKKKELHFL 295 +V +K Q + + E +RL EE++ L + E EN +++ Sbjct: 612 GGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQI------EAENSDLKVNMA 665 Query: 296 QKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKK 355 + S+ + +LLE S +++ +E+ + + + + +E K+ Y S I+ K Sbjct: 666 HRT-SQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAY----SSIAAKN 720 Query: 356 EAKAEELQEAKEKLASLEREASVKRNQ-TREFDGTEVLKGDEFKRYVNKLRSKSTVFKKK 414 +EL E EK+ SLE + + + F+ + + ++ K ++ +KK Sbjct: 721 AELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKK 780 Query: 415 HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSE 474 Q E + +LQ+ + + KQ H +L T E KG +++ E + AL+++ Sbjct: 781 DQQFKEQEKTMSMLQQ-DIICKQHHLESLDRLLT--ESKGEMKKENMKKD-EALKALQNQ 836 Query: 475 VDE--MKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQY 532 V E +K R LD E+ K+ LV + K +QL++K +E+ C +K+ + Sbjct: 837 VSEETIKVRQLDSALEICKE--ELVLHLNQLEGNKEKFEKQLKKKSEEV--YCLQKELKI 892 Query: 533 DSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSD 592 + + S ++ + Q + +++ LQ+E+ N +++ + +L + +++ + Sbjct: 893 KNHSLQETSEQNVILQHTLQQQQQMLQQET---IRNGELEDTQTKLEKQVSKLEQELQKQ 949 Query: 593 QQEKRKAIR--EQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKK 650 ++ + +R E+ ++ A + +L ++QKVI + + +M + E+L + +K Sbjct: 950 RESSAEKLRKMEEKCESAAHEADL-----KRQKVIELTGTARQVKIEMDQYKEELSKMEK 1004 Query: 651 Q 651 + Sbjct: 1005 E 1005 Score = 61.2 bits (147), Expect = 3e-09 Identities = 100/524 (19%), Positives = 223/524 (42%), Gaps = 92/524 (17%) Query: 133 QDETVADTNKQYEELME--AFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVE 190 Q E+ A+ ++ EE E A + K + ++++G + +++ ++ +EE ++ K + Sbjct: 949 QRESSAEKLRKMEEKCESAAHEADLKRQKVIELTG-TARQVKIEMDQYKEELSKMEKEIM 1007 Query: 191 HLKKRVETAQNHQWMLK-IARQLRVEKERE----EYLAQQKQEQKNQLFHAVQRLQRVQN 245 HLK+ E H L I Q + E E++ + L + + + +L A+Q+ + ++ Sbjct: 1008 HLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLET 1067 Query: 246 QLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMG 305 +L++ A + +S +++L+E L V +K LE K + L + E M Sbjct: 1068 ELQN-----AHGELKSTLRQLQE-----LRDVLQKAQLSLEEKYTTIKDLTAELRECKME 1117 Query: 306 HSD----LLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEE 361 D LLE++ + E N E+ +Q+A+ ++ E Sbjct: 1118 IEDKKQELLEMDQALKERNWEL---------------------KQRAAQVTHLDMTIREH 1156 Query: 362 LQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAEL 421 E ++K+ LE + +E + D+ + +LR K + + Q I++L Sbjct: 1157 RGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQL 1216 Query: 422 KAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGR 481 K E ++RT++ +K+ +++Q Q Y TQ + E + Sbjct: 1217 KKE---IERTQQRMKEMESVMKEQEQ----------YIATQYK-EAI------------- 1249 Query: 482 TLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECD-------EKKSQYDS 534 D+ + ++ V + LA + Q +++ + L+ E + EK + + Sbjct: 1250 ---DLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNH 1306 Query: 535 CAAGLESNR-------SKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKA 587 A L +++ ++++ E+++L E + YH + + + + D K+ Sbjct: 1307 LAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKS 1366 Query: 588 YIS--SDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESH 629 + ++Q EK K E+ + NL ++++++ +VI ++ Sbjct: 1367 SVQQLNEQLEKAKLELEEAQDTVS---NLHQQVQDRNEVIEAAN 1407 Score = 53.9 bits (128), Expect = 5e-07 Identities = 59/261 (22%), Positives = 123/261 (47%), Gaps = 20/261 (7%) Query: 115 RAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKD 174 R + + +IKLE E + E + + NKQ E L + L EQL+ F + ++ Sbjct: 1157 RGEMEQKIIKLEGTLEKSELE-LKECNKQIESLNDK---LQNAKEQLREKEFIMLQNEQE 1212 Query: 175 ISAMEEEKD---QLIKRVEHLKKRVET--AQNHQWMLKIARQLRVEKEREEYLAQQKQEQ 229 IS +++E + Q +K +E + K E A ++ + + ++LR+ +E+ + + E Sbjct: 1213 ISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEA 1272 Query: 230 KNQLFHAVQRLQRVQNQLKSMRQAA--ADAKPESLMKRL------EEEIKFNLYMVTEKF 281 ++Q A + ++R+ ++L+ M+Q + DA L + L E ++ + +K Sbjct: 1273 RHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKL 1332 Query: 282 PKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKL 341 E+E+ K+ H +++S + +S+ + + ++N+ +EK + E + + Sbjct: 1333 SAEVESLKEAYH--MEMISHQENHAKWKISADSQKSSVQ-QLNEQLEKAKLELEEAQDTV 1389 Query: 342 SLYRQQASIISRKKEAKAEEL 362 S QQ + EA E L Sbjct: 1390 SNLHQQVQDRNEVIEAANEAL 1410 Score = 45.1 bits (105), Expect = 2e-04 Identities = 67/375 (17%), Positives = 155/375 (41%), Gaps = 50/375 (13%) Query: 300 SEPAMGHSDLLELESKINEINTEINQLIEKKMMRNE-PIEGKLSLYRQQASIISRKKEAK 358 S P + + E KI+ +T+ + KM + P++ ++ R++ + + ++ Sbjct: 189 SHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACL 248 Query: 359 AEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQII 418 + K S+ E + R + + + + ++V + QII Sbjct: 249 VTQNHSLMTKFESIHFELTQSRAKVSMLESAQ--------------QQAASVPILEEQII 294 Query: 419 ---AELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEV 475 AE+ A+ +L+ E L+Q + + ++ Q+++E K EE ++ Sbjct: 295 NLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESK---------EECIKLKV----- 340 Query: 476 DEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSC 535 D+ E K+ ++ AL + +L + +Q+ ++ EK + + Sbjct: 341 ---------DLLEQTKQGKRAERQRNEALYNA----EELSKAFQQYKKKVAEKLEKVQAE 387 Query: 536 AAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMK--AYISSDQ 593 LE N + E+E +RL+E C +S ++ L+ + ++++ A +S+ Sbjct: 388 EEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEV 447 Query: 594 QEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCF 653 + R+ K +E EN + LR+K ++ E+ ++ A E+L C+++ Sbjct: 448 MAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVA---AQNERLDLCQQEIE 504 Query: 654 LKQQSQTSIGQVIQE 668 + S+ ++I + Sbjct: 505 SSRVELRSLEKIISQ 519 >gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 899 Score = 91.3 bits (225), Expect = 3e-18 Identities = 121/603 (20%), Positives = 270/603 (44%), Gaps = 72/603 (11%) Query: 111 ELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAE 170 ELK++ A+FL+ +V + LQ+E +Q EEL E K + K+ E++ Sbjct: 250 ELKRKLERAKFLLP-QVQTNTLQEEMW----RQEEELREQEKKIRKQEEKM---WRQEER 301 Query: 171 IRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKER----EEYLAQQK 226 +R+ M E+++++ ++ + L+++ + + + L+ ++LR ++E+ EE + +Q+ Sbjct: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361 Query: 227 Q---EQKNQLFHAVQRLQRVQNQLKSMRQAAADAKP-----ESLMKRLEEEIKFNLYMVT 278 + EQ+ +++ +RL + Q++ Q D + + ++ EE ++ M Sbjct: 362 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 421 Query: 279 EKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPI- 337 + E K +E + E + E E K+ E + + EK + E + Sbjct: 422 QVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMW 481 Query: 338 EGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLE-----------------REASVKR 380 E + ++QQ ++K + E++QE +EK+ E R+ ++ Sbjct: 482 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE 541 Query: 381 NQTREFDGTEVLKGDEFKRY--VNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQR 438 + + ++ E ++ E K + ++ K+ +KK E E ++ E+ +++ Sbjct: 542 QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 601 Query: 439 HENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDD---MSEMVKKLYS 495 E +++Q + M+E++ QE+ E++ + ++ E + + + M E +K++ Sbjct: 602 EEMMREQEEKMQEQE-----EKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE 656 Query: 496 L--VSEKKSALASVIKELRQLRQKYQE---LTQECDEKKSQYDSCAAGLESNRSKLEQEV 550 + E+K L K Q + + QE QE EKK+Q E + +QE Sbjct: 657 QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQ--------EQEKKTWDQEK 708 Query: 551 RRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAE 610 R E + E + M++ E +++ ++M QE+ + + EQ K + Sbjct: 709 MREEESMREREKKMREEEEMMREQEEKMQEQEEKM--------QEQEEEMWEQEEKMWEQ 760 Query: 611 QENLGKKLR-EKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEG 669 +E + ++ R +QK H +Q K+W E++ + +++ ++ Q + GQ + Sbjct: 761 EEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEK--MRGQEEKMRGQEEKMR 818 Query: 670 GED 672 G++ Sbjct: 819 GQE 821 Score = 77.4 bits (189), Expect = 4e-14 Identities = 103/501 (20%), Positives = 225/501 (44%), Gaps = 56/501 (11%) Query: 169 AEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKE---REEYLAQQ 225 AE+++ + E EK ++ V+ LK+++E A +++L + +++E +EE L +Q Sbjct: 228 AELQEKLPLAESEKSEIQLNVKELKRKLERA---KFLLPQVQTNTLQEEMWRQEEELREQ 284 Query: 226 KQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKEL 285 +++ + Q ++ +R++ Q MR+ + K KRL E+ KEL Sbjct: 285 EKKIRKQEEKMWRQEERLREQEGKMRE--QEEKMWRQEKRLREQ------------EKEL 330 Query: 286 ENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYR 345 ++KEL QK + E + E E K+ E ++ + EK + E + + R Sbjct: 331 REQEKELR-EQKELREQ---EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 386 Query: 346 QQASIIS-------------RKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVL 392 +Q + R+KE + E ++ E++ + E ++ + + D E + Sbjct: 387 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446 Query: 393 KGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEK 452 + +E ++R + +++ + + E + + +Q+ EE + ++ E QQ + E+K Sbjct: 447 QEEE------RIREREKKMREEEETMREQEEK---MQKQEENMWEQEEKEWQQQRLPEQK 497 Query: 453 KGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLY--SLVSEKKSALASVIKE 510 + + QE+ E++ E K R ++M KK++ + E++ + ++ Sbjct: 498 EKLWEQEKMQEQEEKIWE-----QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 552 Query: 511 LRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCM 570 +R QK + +E EKK+Q + + + E+ +R ++ +EE Sbjct: 553 MRDQEQKMWD-QEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611 Query: 571 IKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLR-EKQKVIRESH 629 ++ E +++ ++M QE+ + + EQ K ++E + ++ R +QK H Sbjct: 612 MQEQEEKMQEQEEKMWEQ-EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 670 Query: 630 GPNMKQAKMWRDLEQLMECKK 650 +Q KM E++ E +K Sbjct: 671 EKMQEQEKMQEQEEKIWEQEK 691 Score = 64.7 bits (156), Expect = 3e-10 Identities = 94/432 (21%), Positives = 191/432 (44%), Gaps = 63/432 (14%) Query: 234 FHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELH 293 +H LQR + + S R AD E L K + + LY T +EL+ K EL Sbjct: 175 WHFAGELQRALSAV-STRHKKADRYIEELTKE-RDALSLELYRNTIT-NEELKKKNAELQ 231 Query: 294 FLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISR 353 L ES+ +EI + +L ++K+ R K L + Q + + Sbjct: 232 -------------EKLPLAESEKSEIQLNVKEL-KRKLER-----AKFLLPQVQTNTLQE 272 Query: 354 KKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKK 413 + + EEL+E ++K+ E + + + RE +G + ++ R +LR + ++ Sbjct: 273 EMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELRE 332 Query: 414 KHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKS 473 + + + E K L+ EE ++++ E + +Q + M E++ + QEE R+ + Sbjct: 333 QEKELREQKE----LREQEEQMQEQEEKMWEQEEKMREQEE---KMWRQEE--RLWEQEK 383 Query: 474 EVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYD 533 ++ E + + D M E+ L + +R+ + ++++ + +EKK Q Sbjct: 384 QMREQEQKMRDQEERMW--------EQDERLREKEERMREQEKMWEQVEKMREEKKMQ-- 433 Query: 534 SCAAGLESNRSKLEQEVR-RLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSD 592 EQE + R +EE +QEE R ++ E +R ++M+ + Sbjct: 434 -------------EQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM 480 Query: 593 QQEKRKAIREQ----YTKNTAEQENL---GKKLREKQKVIRESHGPNMKQAKMWRDLEQL 645 +++ K ++Q + EQE + +K+ E+++ IR+ ++ KMWR E++ Sbjct: 481 WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ-EKM 539 Query: 646 MECKKQCFLKQQ 657 E + Q + +++ Sbjct: 540 REQEDQMWEQEE 551 Score = 47.0 bits (110), Expect = 6e-05 Identities = 58/247 (23%), Positives = 110/247 (44%), Gaps = 48/247 (19%) Query: 426 GLLQRTEELLKQRHENIQQQLQTM-EEKKGISGYSY----TQEELERVSALKSEVDEMKG 480 G LQR + RH+ + ++ + +E+ +S Y T EEL++ +A Sbjct: 179 GELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNA---------- 228 Query: 481 RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE 540 E+ +KL L +KS + +KEL++ ++ + L + Q + E Sbjct: 229 -------ELQEKL-PLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ--E 278 Query: 541 SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI 600 + E+++R+ E+ ++E R ++ E ++ R ++ E+ K + Sbjct: 279 EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLR--------EQEKEL 330 Query: 601 REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQ--------AKMWRDLEQLMECKKQC 652 REQ K EQ K+LRE+++ ++E +Q KMWR E+L E +KQ Sbjct: 331 REQ-EKELREQ----KELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ- 384 Query: 653 FLKQQSQ 659 +++Q Q Sbjct: 385 -MREQEQ 390 Score = 42.0 bits (97), Expect = 0.002 Identities = 46/187 (24%), Positives = 88/187 (47%), Gaps = 29/187 (15%) Query: 485 DMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRS 544 D++ + + E + AL++V ++ + +ELT+E D A LE R+ Sbjct: 166 DLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIEELTKERD---------ALSLELYRN 216 Query: 545 KLEQEVRRLREECLQE-----ESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQE---- 595 + E + + LQE ES +K L+ +L RA + ++ QE Sbjct: 217 TITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWR 276 Query: 596 KRKAIREQYTKNTAEQENLGK---KLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQC 652 + + +REQ K ++E + + +LRE++ +RE ++ KMWR ++L E +K+ Sbjct: 277 QEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE------QEEKMWRQEKRLREQEKE- 329 Query: 653 FLKQQSQ 659 L++Q + Sbjct: 330 -LREQEK 335 >gi|71061468 centromere protein E [Homo sapiens] Length = 2701 Score = 90.1 bits (222), Expect = 6e-18 Identities = 123/567 (21%), Positives = 258/567 (45%), Gaps = 80/567 (14%) Query: 146 ELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHL-KKRVETAQNHQW 204 E++ K L + ++++K ++++ ++ E DQL + ++ + K +ET + Sbjct: 1422 EMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE--- 1478 Query: 205 MLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMK 264 LK+A KE+EE + E + L + +Q QL+++ D + + Sbjct: 1479 -LKVAHCCL--KEQEETI----NELRVNLSEKETEISTIQKQLEAIN----DKLQNKIQE 1527 Query: 265 RLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEIN 324 E+E +FN+ ++E K E K+ + H K + ++ S +LEL +++ E EI Sbjct: 1528 IYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSI-ESKMLELTNRLQESQEEIQ 1586 Query: 325 QLI-EKKMMRNEPIEGKLSLYRQQAS-----IISRKKEAKAEELQ--------EAKEKLA 370 +I EK+ M+ ++ L + R Q I+++ KE++ +E Q E +EK+ Sbjct: 1587 IMIKEKEEMKR--VQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMC 1644 Query: 371 SLE--------REASVKRNQTREFDGTEVLKGD-EFKRYVNKLRS-----KSTVFKKKHQ 416 +E ++ +++ +T T++L + E R V K R + T+ ++ Q Sbjct: 1645 EIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQ 1704 Query: 417 IIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGI-----SGYSYTQEELERVS-A 470 + L+ +E LK H ++++ +T+++ +GI + S Q++LE + A Sbjct: 1705 LKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDA 1764 Query: 471 LKSEVDEMKGRT------LDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQE 524 LK++ +++ L + E + KL +VSEK L+++ K+L K QE QE Sbjct: 1765 LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQE 1824 Query: 525 CDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDE 584 + Q + + + K+ E+ +L+++ + NL +L +E Sbjct: 1825 LKANEHQLITLKKDVNETQKKV-SEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEE 1883 Query: 585 MKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQ 644 MK+ + E++NL +++ E K+ R+ ++++ K RDLE Sbjct: 1884 MKSVMK-------------------ERDNL-RRVEETLKLERDQLKESLQETKA-RDLEI 1922 Query: 645 LMECKKQCFLKQQSQTSIGQVIQEGGE 671 E K L ++ + ++ ++ ++ E Sbjct: 1923 QQELKTARMLSKEHKETVDKLREKISE 1949 Score = 82.4 bits (202), Expect = 1e-15 Identities = 125/594 (21%), Positives = 255/594 (42%), Gaps = 100/594 (16%) Query: 145 EELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQW 204 E + +L +Y+ L + ++++ +EK+ L E L+++ + Q Q Sbjct: 494 ENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDL-DEFEALERKTKKDQEMQL 552 Query: 205 MLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMK 264 + +I+ + K E Y Q+ +N+L V+ L+ ++Q+K +++ K ++ Sbjct: 553 IHEISNLKNLVKHAEVY----NQDLENELSSKVELLREKEDQIKKLQEYIDSQK----LE 604 Query: 265 RLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVV----SEPAMGHSDLLELESKINEIN 320 ++ ++ ++L + + PK++ K+ L + V E A S+ LEL+ K+ E+ Sbjct: 605 NIKMDLSYSLESIED--PKQM---KQTLFDAETVALDAKRESAFLRSENLELKEKMKELA 659 Query: 321 TEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEA--------------- 365 T Q+ E + LY+ Q + + +ELQ A Sbjct: 660 TTYKQM-----------ENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKV 708 Query: 366 -KEKLASLEREASV---KRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAEL 421 K+ L +LE E + ++ +E + E L+ + +++L+S + ++ + I + Sbjct: 709 PKDLLCNLELEGKITDLQKELNKEVEENEALREEVI--LLSELKSLPSEVERLRKEIQDK 766 Query: 422 KAEFGLLQRTEELLKQRHENIQQQLQTMEEKKG---------ISGYSYTQEELERVSALK 472 E ++ ++ L + + ++Q + E+ G S Y T +E + L Sbjct: 767 SEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLH 826 Query: 473 SEVDEMKGRTLDDMSEMVKKLYSLVSEKK---SALASVIKELRQLRQKYQELTQECDEKK 529 + ++ L++ M +++ +L E + S+L ++ EL Q+ QE T+E E+ Sbjct: 827 MDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERL 886 Query: 530 SQYDSCAAGLESNRSKLE-----------------QEVRRLREE-----CLQE------- 560 ++ + LE+ S L+ +EV+ L +E LQE Sbjct: 887 NEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERD 946 Query: 561 --ESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKL 618 +S H T M + + QLR A + +K + + K K I E+ ++N +EN G+ Sbjct: 947 QLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSK-ISEEVSRNLHMEENTGETK 1005 Query: 619 RE-KQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGE 671 E +QK++ G + KQ ++ + L K + +Q Q I +IQE E Sbjct: 1006 DEFQQKMV----GIDKKQDLEAKNTQTLTADVKDNEIIEQ-QRKIFSLIQEKNE 1054 Score = 80.9 bits (198), Expect = 4e-15 Identities = 116/548 (21%), Positives = 237/548 (43%), Gaps = 68/548 (12%) Query: 145 EELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKR---VEHLK-KRVETAQ 200 E+L E + L ++ +QL +E++K I+ +E K++L + +EH++ +R+E AQ Sbjct: 1127 EKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQ 1186 Query: 201 ----NHQWMLKIARQLRVEKEREEYLA------------------QQKQEQKNQLFHAVQ 238 N++ + I ++ +V KE ++ Q K+E K H + Sbjct: 1187 KLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKE 1246 Query: 239 RLQRVQNQLKSMRQAAADA-KPESLMK---RLEEEIKFNLYMVTEKFP--KELENKKKEL 292 + + +S+ + A + L K +L+EEI L+ E P KE+ ++ + Sbjct: 1247 HQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPV-LHEEQELLPNVKEVSETQETM 1305 Query: 293 HFLQKVVSEPAMGHS--------DLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLY 344 + L+ + + S + L L K E EI L K+ + I+ L + Sbjct: 1306 NELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLT-KERDNLKTIKEALEVK 1364 Query: 345 RQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKL 404 Q R+ AK +E Q +E+ +++ + + E + + K R ++ Sbjct: 1365 HDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKP-KDSALLRIEIEM 1423 Query: 405 RSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEE 464 S ++ H + + E LQR +E+L+ + +++ + K+ ++ + T+EE Sbjct: 1424 LGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI-----KEIVAKHLETEEE 1478 Query: 465 LERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQE 524 L+ L + E + +L +SEK++ ++++ K+L + K Q QE Sbjct: 1479 LKVAHCC-----------LKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQE 1527 Query: 525 CDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDE 584 EK+ Q++ S + E+++ +E ++S + L +L+ + +E Sbjct: 1528 IYEKEEQFNIKQI---SEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEE 1584 Query: 585 MKAYISSDQQEKR-----KAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMW 639 ++ I ++ KR + R+Q +NT E K+ +EK+ + N Q KM Sbjct: 1585 IQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMC 1644 Query: 640 RDLEQLME 647 ++E L E Sbjct: 1645 -EIEHLKE 1651 Score = 80.5 bits (197), Expect = 5e-15 Identities = 117/578 (20%), Positives = 250/578 (43%), Gaps = 88/578 (15%) Query: 136 TVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKR 195 T K ++ + FKTLH ++EQ + EE +++ + + +L K Sbjct: 807 TTQSNYKSTDQEFQNFKTLHMDFEQ-------------KYKMVLEENERMNQEIVNLSKE 853 Query: 196 VETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAA 255 + K L K Y Q+ QE+ ++ + +++++ QL++ Sbjct: 854 AQ---------KFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENR----- 899 Query: 256 DAKPESLMKRLEEEIKFNLYMVTEKFPKELE------NKKKELHFLQKVVS-EPAMGHSD 308 +S ++ +E E ++TEK + LE +K +L LQ+ + E SD Sbjct: 900 ----DSTLQTVERE----KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSD 951 Query: 309 LLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEK 368 + + + + ++ +E E I S ++ S +E E E ++K Sbjct: 952 IHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQK 1011 Query: 369 LASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLL 428 + ++++ ++ T+ T +K +E + + R ++ ++K+++ L++ ++ Sbjct: 1012 MVGIDKKQDLEAKNTQTL--TADVKDNEI---IEQQRKIFSLIQEKNELQQMLES---VI 1063 Query: 429 QRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEEL---ERVSALKSEVDEMKGRTLDD 485 E+L ENI+ ++ EE + + Q+E+ E+ A+K E + RT D Sbjct: 1064 AEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGE--LSRTCDR 1121 Query: 486 MSEMVKKL---YSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESN 542 ++E+ +KL + EK+ L +V +E+ ++++K E+ +E K++ + +E+ Sbjct: 1122 LAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNK-ELTLEHMETE 1180 Query: 543 RSKLEQEVRRLREE---------CLQE-----ESRYHYTNCMIKNLEVQLRRATDEMK-- 586 R +L Q++ EE L+E E+ + I+ +E + +E+K Sbjct: 1181 RLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIA 1240 Query: 587 -AYISSDQQ---EKRKAIREQYTK--NTAEQENLGKKLREKQKVIRESHG--PNMKQAKM 638 ++ Q+ E R+++ E+ + NT + E KL+E+ V+ E PN+K+ Sbjct: 1241 HIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSE 1300 Query: 639 WRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGEDRLIL 676 ++ +E L +QS T + +RL L Sbjct: 1301 TQETMNELE-----LLTEQSTTKDSTTLARIEMERLRL 1333 Score = 75.9 bits (185), Expect = 1e-13 Identities = 109/561 (19%), Positives = 230/561 (40%), Gaps = 78/561 (13%) Query: 135 ETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKK 194 E V ++ ++L + ++L E +QLK ++I ++ + ++QL +E LK+ Sbjct: 922 EEVKTLTQEKDDLKQLQESLQIERDQLK------SDIHDTVNMNIDTQEQLRNALESLKQ 975 Query: 195 RVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQN-QLKSMRQA 253 ET + ++ E R ++ + E K++ + + + Q+ + K+ + Sbjct: 976 HQETINT------LKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTL 1029 Query: 254 AADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELE 313 AD K ++++ K ++ K + L+ V++E +DL E Sbjct: 1030 TADVKDNEIIEQ------------QRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENI 1077 Query: 314 SKINEINTEINQLIEKKMMRNEPI----------EGKLSLYRQQASIISRKKEAKAEELQ 363 E E+ L ++ + E + EG+LS + + + K + K+++LQ Sbjct: 1078 EMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137 Query: 364 EAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKA 423 E +++L +++ E S + + E + + +E K L T + Q + E Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLK----NELKNKELTLEHMETERLELAQKLNENYE 1193 Query: 424 EFGLLQRTEELLKQRHENIQQQ---------------LQTMEEKKGISGYSYTQEELERV 468 E + + ++LK+ ++ + + LQT EE K + + +E E + Sbjct: 1194 EVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELK--IAHIHLKEHQETI 1251 Query: 469 SALKSEVDEMKGRTLD--DMSEMVKKLYS--LVSEKKSALASVIKELRQLRQKYQELTQE 524 L+ V E + ++ D+ + KL V ++ L +KE+ + ++ EL Sbjct: 1252 DELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELL 1311 Query: 525 CDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEV---QLRRA 581 ++ ++ + A +E R +L ++ + +EE + + LEV QL+ Sbjct: 1312 TEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEH 1371 Query: 582 TDEMKAYISSDQQEKRKAIR-----EQYTKNTAEQENLGKK----------LREKQKVIR 626 E A I Q ++ +++ + TK +E E K + K ++ Sbjct: 1372 IRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQ 1431 Query: 627 ESHGPNMKQAKMWRDLEQLME 647 ESH AK DL++L E Sbjct: 1432 ESHDEMKSVAKEKDDLQRLQE 1452 Score = 75.1 bits (183), Expect = 2e-13 Identities = 150/726 (20%), Positives = 317/726 (43%), Gaps = 116/726 (15%) Query: 27 DSLEPMQ-LLQVLSDVLAEIDPKQLVDIREEMPEQTA------KRMLSLLGILKYKPSGN 79 D L+ +Q +LQ SD L E + K++V E E+ K + L+ S Sbjct: 1445 DDLQRLQEVLQSESDQLKE-NIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEK 1503 Query: 80 ATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKR---AYLARFLIKLEVPSEFLQDET 136 T++ST ++ L I L +Q E +++ ++ K+ +F + Sbjct: 1504 ETEISTIQKQL-----EAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRK 1558 Query: 137 VADTNKQYEE--LMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKK 194 D+ Q E ++E L + E+++I E+++ A++ E+DQL + + + Sbjct: 1559 AKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVA 1618 Query: 195 RVETAQN--HQWMLKIARQLRVEKERE-EYLAQQKQEQKNQLFHA----VQRLQRVQNQL 247 +++ +Q +Q++ A EK E E+L +Q + QK L + ++ Q + L Sbjct: 1619 KMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENL 1678 Query: 248 KSMRQAAADAKP----ESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPA 303 + MR + E +K +++K NL E ++LE K++EL K+V Sbjct: 1679 EEMRSVTKERDDLRSVEETLKVERDQLKENL---RETITRDLE-KQEEL----KIVHMHL 1730 Query: 304 MGHSDLLE-LESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEEL 362 H + ++ L ++E EI+ + + N+ ++ + +++ I + + E + Sbjct: 1731 KEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETI 1790 Query: 363 Q-------EAKEKLASLEREASVKRNQTREFDGTEVLKGDE-----FKRYVNKLRSKSTV 410 E +KL++++++ ++ + + + + LK +E K+ VN+ + K + Sbjct: 1791 DKLRGIVSEKTDKLSNMQKD--LENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVS- 1847 Query: 411 FKKKHQIIAELKAEFGLLQRTE----ELLKQRHENIQQQLQTMEEKKGISGYSYTQEELE 466 + Q+ ++K + L + E L ++ HEN+++ M+E+ + T + LE Sbjct: 1848 --EMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLK-LE 1904 Query: 467 RVSALKSEVDEMKGRTLDDMSEM-------------VKKLYSLVSEKKSALASVIKEL-- 511 R LK + E K R L+ E+ V KL +SEK ++ + K+L Sbjct: 1905 R-DQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDK 1963 Query: 512 --RQLRQKYQELTQ--------------------ECDEKKSQYDSCAAGLESNRSKLEQE 549 +L++K QEL + E ++ K Q+++ ++S R Q Sbjct: 1964 SKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQL 2023 Query: 550 VRRLREECLQEESRYHYTNCMIKNLEVQLRRATDE----MKAYISSDQQEKRKAIREQYT 605 ++L E L+E ++ ++ L+ D+ ++ I+ D+Q + ++ + Sbjct: 2024 TKKLHES-LEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQ--VKPEKR 2080 Query: 606 KNTAEQENLGKKLREKQKVIRE---------SHGPNMKQAKMWRDLEQLMECKKQCFLKQ 656 + Q++L + LREK I+E H + + + DLE+ +E +K+ ++ Sbjct: 2081 LLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSL--DLEKEIEFQKELSMRV 2138 Query: 657 QSQTSI 662 ++ S+ Sbjct: 2139 KANLSL 2144 Score = 71.2 bits (173), Expect = 3e-12 Identities = 136/636 (21%), Positives = 267/636 (41%), Gaps = 128/636 (20%) Query: 144 YEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAME-----EEKDQLIKRVEHLKKRVET 198 Y+ L+ ++ L E E++++ ++ + A+E +++ QLI + +LK V+ Sbjct: 507 YDNLVLDYEQLRTEKEEMELKLKEKNDL-DEFEALERKTKKDQEMQLIHEISNLKNLVKH 565 Query: 199 AQNHQWMLKIARQLRVE---------KEREEYLAQQKQEQ-KNQLFHAVQRLQ---RVQN 245 A+ + L+ +VE K+ +EY+ QK E K L ++++ ++ +++ Sbjct: 566 AEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQ 625 Query: 246 QLKSMRQAAADAKPESLMKR---LEEEIKFNLYMVTEK--------FPKELENKKKELHF 294 L A DAK ES R LE + K T K + +LE KKK Sbjct: 626 TLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVD 685 Query: 295 LQKVVSEPAMGHSDL---------------LELESKINEINTEINQLIEK-KMMRNEPIE 338 L+K + + L LELE KI ++ E+N+ +E+ + +R E I Sbjct: 686 LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL 745 Query: 339 -GKLSLYRQQASIISRKKEAKAEELQ---EAKEKLAS--LEREASVK------------- 379 +L + + ++ + K+EEL K+KL S + +E+ V+ Sbjct: 746 LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL 805 Query: 380 -------RNQTREFDGTEVLKGD----------EFKRYVNKLRSKSTVFKKKHQIIAELK 422 ++ +EF + L D E +R ++ + S +K + LK Sbjct: 806 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK 865 Query: 423 AEFG-----LLQRTEEL---------LKQRHENIQQQLQTMEEKKGISGYSYTQEELERV 468 E L ++T E+ LK++ EN LQT+E +K + Q+ LE V Sbjct: 866 TELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLI-TEKLQQTLEEV 924 Query: 469 SALKSEVDEMK----------GRTLDDMSEMVKKLYSLVSEKKSALASVIKE---LRQLR 515 L E D++K + D+ + V + ++AL S+ + + L+ Sbjct: 925 KTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLK 984 Query: 516 QKYQE-------LTQECDEKKSQYDSCAAGLESNRSKLEQEVRRL----REECLQEESRY 564 K E + + E K ++ G++ + + + L ++ + E+ R Sbjct: 985 SKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRK 1044 Query: 565 HYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKV 624 ++ KN Q+ + K + +D +E E +N E LG +L+++Q++ Sbjct: 1045 IFSLIQEKNELQQMLESVIAEKEQLKTDLKEN----IEMTIENQEELRLLGDELKKQQEI 1100 Query: 625 I-RESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQ 659 + +E + K+ ++ R ++L E +++ LK++SQ Sbjct: 1101 VAQEKNHAIKKEGELSRTCDRLAEVEEK--LKEKSQ 1134 Score = 42.0 bits (97), Expect = 0.002 Identities = 90/450 (20%), Positives = 173/450 (38%), Gaps = 79/450 (17%) Query: 126 EVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQL 185 E PS + + V K+ + +E + + E+LK + +++E D++ Sbjct: 2250 EFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLK-------------NGIQKENDRI 2296 Query: 186 IKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQN 245 + R+ N + R + KE E+ L K E+ +LF Q L+ Sbjct: 2297 CQVNNFFNNRIIAIMNESTEFE-ERSATISKEWEQDLKSLK-EKNEKLFKNYQTLKTSLA 2354 Query: 246 QLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELEN-----KKKELHFLQKVVS 300 + D K + R + + TEK +ELEN K+ +H K++ Sbjct: 2355 SGAQVNPTTQDNKNPHVTSRATQ-------LTTEKI-RELENSLHEAKESAMHKESKIIK 2406 Query: 301 ---EPAMGHSDLLELESKINEINT-------EINQLIEKKMMRNEPIEGKLSLYRQQASI 350 E + + + +L++K++E N I L +K + +P + ++ + + Sbjct: 2407 MQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVK 2466 Query: 351 ISRKKEAKAEELQ-EAKEKLASLEREASVKR------NQTREFDGTEVLKGDEFKRYVNK 403 I +K A+E + E A++E + V R ++++ T V+ + NK Sbjct: 2467 IDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNK 2526 Query: 404 -----------LRSKSTVFKKKHQIIAELKAEFGLL-QRTEELLKQRHENIQQQLQTMEE 451 +K+ + K +H L+ E L Q+ E+L+KQ++E + E Sbjct: 2527 PLTCGGGSGIVQNTKALILKSEH---IRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNE 2583 Query: 452 KKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKEL 511 K ++ + L+R E + + S K+ S+KK S KE Sbjct: 2584 VK-----TWKERTLKR---------EAHKQVTCENSPKSPKVTGTASKKKQITPSQCKE- 2628 Query: 512 RQLRQKYQELTQECDEKKSQYDSCAAGLES 541 + Q+ + K +DS + L S Sbjct: 2629 ----RNLQDPVPKESPKSCFFDSRSKSLPS 2654 >gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] Length = 2115 Score = 89.0 bits (219), Expect = 1e-17 Identities = 126/590 (21%), Positives = 255/590 (43%), Gaps = 76/590 (12%) Query: 142 KQYEEL-MEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETA- 199 KQ E L E L +QL+++ + + ++ + EK +L ++VE L+ VETA Sbjct: 604 KQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETAR 663 Query: 200 -QNHQWMLKIAR---QLRVEKER---EEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQ 252 + H+ ++A QLR E+++ +E +AQ+K + + QL + L+ + L+ ++ Sbjct: 664 QEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR 723 Query: 253 AAADAKPESLMKRLEEEIKFNLYMVTEKFP---KELENKKKELHFLQKVVSEPAMGHS-- 307 AADA E +R E+K + E+ KELE ++ L+ + + H Sbjct: 724 RAADALEEQ--QRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAE 781 Query: 308 ------DLLELESKINEINTEINQLIEKKMMRNEPIEGKL-------SLYRQQASIISRK 354 +L E + + +E QL+++ E E +++++Q + + Sbjct: 782 TEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEE 841 Query: 355 KEAKAEELQEAKEKLASLER----EASVKRNQTREFDGT----------EVLKGDEFKRY 400 E +ELQEAKEK+A +E + S ++N+ E + ++ + Sbjct: 842 CEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADD 901 Query: 401 VNKLRSKSTVFKKKHQIIAELKAEFGLLQRT--EELLKQRHENIQQQLQTMEEKKGISGY 458 ++ L+ K K+ + L + G Q T EL+K+ +Q + +EE++G + Sbjct: 902 LSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQG-RQF 960 Query: 459 SYTQEELE-----------RVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASV 507 TQ L+ + L++ + E +G+ ++ + +++ L E+ A A + Sbjct: 961 CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL 1020 Query: 508 IKELRQLRQKYQELTQECDEKKSQY----DSCAAGLESNRSKLEQEVRRLREECLQEESR 563 E + L +E++ ++ ++ A L K +QE+ +LR Sbjct: 1021 ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGK-DQELAKLR--------- 1070 Query: 564 YHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQK 623 IK LE +LR+ ++K ++ ++E Q ++ E G KL + Sbjct: 1071 -GLEAAQIKELE-ELRQTVKQLKEQLAKKEKEHASGSGAQ-SEAAGRTEPTGPKLEALRA 1127 Query: 624 VIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQS--QTSIGQVIQEGGE 671 + + KQ + LE+ +E ++ ++ S +T GQ+ ++ E Sbjct: 1128 EVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQE 1177 Score = 78.6 bits (192), Expect = 2e-14 Identities = 149/601 (24%), Positives = 251/601 (41%), Gaps = 98/601 (16%) Query: 142 KQYEELMEAFKTLH-----KEYEQLKISGF-STAEIRKDISA--MEEEKDQLIKRVEHLK 193 K+ EEL + K L KE E SG S A R + + +E + ++ K + + Sbjct: 1078 KELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQ 1137 Query: 194 KRVETAQNHQWMLKIARQLRVEKERE-EYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQ 252 K+ E A + + L+ R R E++ E L Q +E+ +L H+ L Q +L + R Sbjct: 1138 KQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRT 1197 Query: 253 AAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLEL 312 D + E+E K + + +E E K + L++ VS + + +LE Sbjct: 1198 KVQDHS------KAEDEWKAQV----ARGRQEAERKNSLISSLEEEVS---ILNRQVLEK 1244 Query: 313 ESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASL 372 E + + E+ +L+ + +++ +E +L L QA S A AE +E++ SL Sbjct: 1245 EGE----SKELKRLVMAESEKSQKLEERLRLL--QAETASNSARA-AERSSALREEVQSL 1297 Query: 373 EREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQR-T 431 EA +R + + + + +L++ F +K Q ++ L+ E Q Sbjct: 1298 REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV 1357 Query: 432 EELLKQRHENIQQQLQT------------MEEKKGISG-----YSYTQEELERVSALKSE 474 ELL +H + QQLQ +E+ K +G Q EL + L+ + Sbjct: 1358 SELLPAKH--LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQK 1415 Query: 475 VDEMKGRTLDDMS----------EMVKKLYSLVSEKKSALASVIK--------ELRQLRQ 516 V E + RT + M+KK + L++E+ L EL Q R+ Sbjct: 1416 VAEQE-RTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE 1474 Query: 517 KY-QELTQ-------ECDEKKSQYDSCAAGLESNRSKLE-QEVRRLREECLQEESRYHYT 567 KY QEL E + + S A LE +K E +V+ L E +E R T Sbjct: 1475 KYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLT 1534 Query: 568 NCMIKNLEVQLRRATDEM----KAYISSDQ-----QEKRKAIREQYTKNTAEQENLGKKL 618 ++ LEV R T ++ K SDQ Q+K KA++ Q ++ E + L +L Sbjct: 1535 -AQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQL 1593 Query: 619 REKQKVI------RESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGED 672 E Q + E + M++AK D + K+Q Q+ S+ Q+ +E E Sbjct: 1594 NELQAQLSQKEQAAEHYKLQMEKAKTHYDAK-----KQQNQELQEQLRSLEQLQKENKEL 1648 Query: 673 R 673 R Sbjct: 1649 R 1649 Score = 73.2 bits (178), Expect = 8e-13 Identities = 104/507 (20%), Positives = 219/507 (43%), Gaps = 47/507 (9%) Query: 171 IRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQK 230 ++++ + + QL RVE L ET + Q +A + E+E+ QQ Sbjct: 418 LKQEAATLAANNTQLQARVEML----ETERGQQEAKLLAERGHFEEEK-----QQLSSLI 468 Query: 231 NQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKK 290 L ++ L + + +L+ QA A+ + + L E+ L ++ +EL K+ Sbjct: 469 TDLQSSISNLSQAKEELEQASQAHG-ARLTAQVASLTSELT-TLNATIQQQDQELAGLKQ 526 Query: 291 ELHFLQKVVSEPAMGHSDLLE-LESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQAS 349 + Q +++ + L ++ ++++ + Q ++ E E + QQ + Sbjct: 527 QAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLA 586 Query: 350 IISRKKEAKAEELQEAKEKLASLEREASVK----------RNQTREFDGTEVLKGD---- 395 + ++EA E A ++L +LE+E + K N+ R+ T V + Sbjct: 587 TAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKA 646 Query: 396 EFKRYVNKLRS-KSTVFKKKHQIIAELKAEFGLLQRTE-------ELLKQRHENIQQQLQ 447 E R V +L++ T +++H+ A++ AE L R+E E + Q + +Q+QLQ Sbjct: 647 ELSRKVEELQACVETARQEQHEAQAQV-AELELQLRSEQQKATEKERVAQEKDQLQEQLQ 705 Query: 448 TMEEKKGISGYSYTQEELERVSALKSE---VDEMKGRTLDDMSEMVKKLYSLVSEKKSAL 504 ++E ++ S +E+ AL+ + + E+K T + E K+ + E+++ Sbjct: 706 ALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAET-RSLVEQHKRERKELEEERAGR 764 Query: 505 ASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEV---RRLREECLQEE 561 + L+QL + +Q T+ + ++ + ES +L +EV R E+ QEE Sbjct: 765 KGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEE 824 Query: 562 SRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQEN-LGKKLRE 620 ++Y M + + L+ ++ + + + +EK I + Q+N L + Sbjct: 825 AQY---GAMFQEQLMTLKEECEKARQEL-QEAKEKVAGIESHSELQISRQQNELAELHAN 880 Query: 621 KQKVIRESHGPNMKQAKMWRDLEQLME 647 + +++ ++ K+ DL L E Sbjct: 881 LARALQQVQEKEVRAQKLADDLSTLQE 907 Score = 68.9 bits (167), Expect = 1e-11 Identities = 113/535 (21%), Positives = 224/535 (41%), Gaps = 74/535 (13%) Query: 161 LKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREE 220 L+ F ++K ++ +D+L +E A+N + + + Q+ + ++R + Sbjct: 209 LQTPQFQMRRLKKQLADERSNRDEL---------ELELAENRKLLTEKDAQIAMMQQRID 259 Query: 221 YLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEK 280 LA ++Q A L+ +L+ +R K ESL RL E +K + TEK Sbjct: 260 RLALLNEKQ------AASPLE--PKELEELRD-----KNESLTMRLHETLKQCQDLKTEK 306 Query: 281 FP-----KELENKKKELHF-----------LQKVVSEPAMGHSDLL-ELESKINEINTEI 323 +L + +L F LQ ++E HS E K ++ E+ Sbjct: 307 SQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKEL 366 Query: 324 NQLIEKKMM---RNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLERE-ASVK 379 + ++ K +NE ++GKLS + S + + E+ +L +L++E A++ Sbjct: 367 SAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLA 426 Query: 380 RNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRH 439 N T+ E+L+ + ++ KL ++ F+++ Q ++ L + L+ Sbjct: 427 ANNTQLQARVEMLETERGQQEA-KLLAERGHFEEEKQQLSSLITD----------LQSSI 475 Query: 440 ENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSE 499 N+ Q + +E+ G T + V++L SE+ + T+ + + L E Sbjct: 476 SNLSQAKEELEQASQAHGARLTAQ----VASLTSELTTLNA-TIQQQDQELAGLKQQAKE 530 Query: 500 KKSALASVIKELRQ----LRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLRE 555 K++ LA +++ Q LR + ++L+ +K+ Q A E+ R Q++ E Sbjct: 531 KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAE 590 Query: 556 ECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQ--QEKRKAIREQYTKNTAEQEN 613 E E+ + +K LE + +++ Q E R + + T+ E+ Sbjct: 591 E---REASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAE 647 Query: 614 LGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQE 668 L +K+ E Q + E+ +A+ Q+ E + Q +QQ T +V QE Sbjct: 648 LSRKVEELQACV-ETARQEQHEAQ-----AQVAELELQLRSEQQKATEKERVAQE 696 Score = 68.9 bits (167), Expect = 1e-11 Identities = 116/552 (21%), Positives = 228/552 (41%), Gaps = 67/552 (12%) Query: 132 LQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEH 191 ++ + ++Q EL E L + +Q++ ++ D+S ++E+ K V Sbjct: 859 IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918 Query: 192 LKKRVETAQNHQWMLK---IARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQR----VQ 244 L+ V A Q + R + E+L +Q+ Q A+Q ++R + Sbjct: 919 LETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMG 978 Query: 245 NQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAM 304 N+L+ +R A +++ + +R ++E +E+ +E Q ++ Sbjct: 979 NELERLRAALMESQGQQQEERGQQE-------------REVARLTQERGRAQADLALEKA 1025 Query: 305 GHSDL-LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQ 363 ++L + L++ +NE E L E EGK Q+ + + + A+ +EL+ Sbjct: 1026 ARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGK----DQELAKLRGLEAAQIKELE 1081 Query: 364 EAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKA 423 E ++ + L+ + + K + G + + KL + K Q + + Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141 Query: 424 EFGLLQRTEELLKQRHENIQQQLQTM----EEKKGISGYSYT-----QEELE----RVSA 470 + L+R+ E + L+T+ EEK G+S + Q EL +V Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201 Query: 471 LKSEVDEMKGRTLDDMSEMVKK--LYSLVSEKKSALASVI-------KELRQLRQKYQEL 521 DE K + E +K L S + E+ S L + KEL++L E Sbjct: 1202 HSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEK 1261 Query: 522 TQECDEK----KSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQ 577 +Q+ +E+ +++ S +A S L +EV+ LREE E+ R N + + L Q Sbjct: 1262 SQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEA--EKQRVASEN-LRQELTSQ 1318 Query: 578 LRRATD---EMKAYISSDQQEKRKAIREQYTKNTAEQ---------ENLGKKLREKQKVI 625 RA + E+KA+ Q K +A+ ++T+ Q ++L ++L+ +Q Sbjct: 1319 AERAEELGQELKAWQEKFFQ-KEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAA 1377 Query: 626 RESHGPNMKQAK 637 + H ++Q+K Sbjct: 1378 EKRHREELEQSK 1389 Score = 55.1 bits (131), Expect = 2e-07 Identities = 93/463 (20%), Positives = 188/463 (40%), Gaps = 68/463 (14%) Query: 124 KLEVPSEFLQDETVADTNKQYEE---LMEAFKTLHKEYEQLKISGFS-----------TA 169 KLE LQ ET +++ + E L E ++L +E E+ +++ + Sbjct: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323 Query: 170 EIRKDISAMEE---EKDQLIK--RVEHLKKRVETAQ----NHQWMLKIARQLRVEKEREE 220 E+ +++ A +E +K+Q + ++EH + ++ H A Q EK E Sbjct: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383 Query: 221 YLAQQKQEQ---KNQLFHAVQRL-------QRVQNQLKSMRQAAAD----AKPESLMKR- 265 L Q KQ + +L A + L Q+V Q ++ +Q A+ A+ S++K+ Sbjct: 1384 ELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKA 1443 Query: 266 ---LEEE--------------IKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSD 308 L EE ++ L EK+ +EL + + V A + Sbjct: 1444 HGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTAR 1503 Query: 309 LLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEK 368 LE+ + E ++ L E++ + E KL+ +Q + R++ + EEL + K Sbjct: 1504 ELEVMTAKYE-GAKVKVLEERQRFQEE--RQKLTAQVEQLEVFQREQTKQVEELSK---K 1557 Query: 369 LASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLL 428 LA ++ + V++ + + E +R +L +K Q K + Sbjct: 1558 LADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKA 1617 Query: 429 QRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSE 488 + + KQ+++ +Q+QL+++E+ +EL + + G + + Sbjct: 1618 KTHYDAKKQQNQELQEQLRSLEQ------LQKENKELRAEAERLGHELQQAGLKTKEAEQ 1671 Query: 489 MVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQ 531 + L + V ++ +A ++LR L K+Q T ++ Q Sbjct: 1672 TCRHLTAQVRSLEAQVAHADQQLRDL-GKFQVATDALKSREPQ 1713 >gi|64085252 hypothetical protein LOC145508 [Homo sapiens] Length = 1094 Score = 88.6 bits (218), Expect = 2e-17 Identities = 109/512 (21%), Positives = 225/512 (43%), Gaps = 57/512 (11%) Query: 178 MEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQL-RVEKERE------EYLAQQKQEQK 230 +E EK L K++ L+ ++ + + ++ R + R +KE+ E L ++ + + Sbjct: 354 VEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGE 413 Query: 231 NQLFHAVQRLQRVQNQLKSMR--QAAADAKPESLMKRLEEEIK-----FNLYMVTEKFPK 283 Q + RL+ +QN + + AD + L + E+ K + +E + Sbjct: 414 KQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKE 473 Query: 284 ELENKKKELHF-LQKVVSEPAMGHSDL---LELESK-INEINTEINQLIEKKMMRNEPIE 338 E E ++++L Q+ + + + H L LE +S+ ++E+ + NQ++++K E Sbjct: 474 EAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKD------E 527 Query: 339 GKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFK 398 K LY I + +KE L + K A E E K + R+ + E K Sbjct: 528 LKTQLYAALQQIENLRKE-----LNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVK 582 Query: 399 RYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGY 458 ++ + + KK+ +I +++K E L+ EE+ + + Q + + +E ++ I Sbjct: 583 NSLDTIHRLESELKKQSKIQSQMKVEKAHLE--EEIAELKKSQAQDKAKLLEMQESIKDL 640 Query: 459 SYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKY 518 S + +L A E + K L D+S++ + S E + + + E +++ Sbjct: 641 SAIRADLANKLA---EEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQREL 697 Query: 519 QELTQECDEKKSQYDSCAAGL----ESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNL 574 ++LT K++++ L + +S+ E +R L+ E L+E++ ++ L Sbjct: 698 KDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKL 757 Query: 575 EVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMK 634 + Q R T+E+ ++ + K+ ++ Q K+ E+ REK I E H M+ Sbjct: 758 KSQCDRLTEEL---TQNENENKKLKLKYQCLKDQLEE-------REKHISIEEEHLRRME 807 Query: 635 QAKMWRDLEQLMECKKQCFLKQQSQTSIGQVI 666 +A+ ++ K Q + Q SI VI Sbjct: 808 EAR--------LQLKDQLLCLETEQESILGVI 831 Score = 48.9 bits (115), Expect = 2e-05 Identities = 116/566 (20%), Positives = 229/566 (40%), Gaps = 55/566 (9%) Query: 39 SDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILK-YKPSGNATDMSTFRQGLVIGSKPV 97 S+ L E K+ D++ + E + L + + + D T + ++ K Sbjct: 468 SEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDE 527 Query: 98 IYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFL--QDETVADTNKQYEEL----MEAF 151 + L+ LQ+ L+K L L K + E L ++E + D +L + Sbjct: 528 LKTQLYAALQQIENLRKE--LNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSL 585 Query: 152 KTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQ 211 T+H+ +LK + K S M+ EK L + + LKK AQ+ +L++ Sbjct: 586 DTIHRLESELK-------KQSKIQSQMKVEKAHLEEEIAELKK--SQAQDKAKLLEMQES 636 Query: 212 LRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKR--LEEE 269 ++ LA + E++ ++ L + Q KS + A + ++R + E Sbjct: 637 IKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRE 696 Query: 270 IKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELES------------KIN 317 +K + K +N ++ + +K SE A H L+ ES ++ Sbjct: 697 LKDLTSSLQSVKTKHEQNIQELMKHFKKEKSE-AENHIRTLKAESLEEKNMAKIHRGQLE 755 Query: 318 EINTEINQLIEKKMMRNEPIEGKLSLYRQ--QASIISRKKEAKAEE-----LQEA----K 366 ++ ++ ++L E ++ +NE KL L Q + + R+K EE ++EA K Sbjct: 756 KLKSQCDRLTE-ELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLK 814 Query: 367 EKLASLERE-ASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEF 425 ++L LE E S+ +E D + + S + H+ +AE K + Sbjct: 815 DQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKL 874 Query: 426 GLLQRTEELLKQRHENI-------QQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEM 478 L + + R +N+ +QQL+ + E K S +++ER L E+ Sbjct: 875 QWLCEELKERENREKNLRHQLMLCRQQLRNLTENKE-SELQCLFQQIERQEQLLDEIHRE 933 Query: 479 KGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAG 538 K L++ +++ SL ++ AL + + + E ++ K DSC++ Sbjct: 934 KRDLLEETQRKDEEMGSL-QDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSS 992 Query: 539 LESNRSKLEQEVRRLREECLQEESRY 564 ++ + VRR + Q++++Y Sbjct: 993 ERTDGRYSKYRVRRNSLQHHQDDTKY 1018 Score = 35.8 bits (81), Expect = 0.13 Identities = 65/346 (18%), Positives = 138/346 (39%), Gaps = 51/346 (14%) Query: 310 LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQ-QASIISRKKEAKAEELQEAKEK 368 +E+ K+N I + + Q + + + + + G+ Y QA I KE+ + + + + + Sbjct: 35 VEVTEKVNTITSTL-QDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQ 93 Query: 369 LA---SLEREASVKRNQTREFDG-----------TEVLKGDEFKRYVNKLRSKSTV-FKK 413 S R SV + DG T LK + + ++RS++ V F + Sbjct: 94 RLLRNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGIKRMRSRTGVRFVQ 153 Query: 414 KHQIIAELKAEFGLLQRTEELLKQR--------HENIQQQLQTMEEKKGISGYSYTQEEL 465 + + +L G Q +L ++ E ++ E K+ + + E Sbjct: 154 ETDDMTQLH---GFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEA 210 Query: 466 ERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQEC 525 ++ + V+ R L ++ ++ LV ++ L + +L++ +K + + Sbjct: 211 QKQEVVSDRVE----RRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEA---KA 263 Query: 526 DEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEM 585 DE + + E+ +++LEQE+ R Q E ++ L QL +A + Sbjct: 264 DEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGD- 322 Query: 586 KAYISSDQQEKRKAIREQYTKNTAEQENL----GKKLREKQKVIRE 627 RK ++ Q ++ + +Q N G+ R ++ V RE Sbjct: 323 -----------RKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVERE 357 >gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sapiens] Length = 1843 Score = 88.2 bits (217), Expect = 2e-17 Identities = 118/530 (22%), Positives = 240/530 (45%), Gaps = 55/530 (10%) Query: 126 EVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQL 185 E P + L E T+ + +L ++L K E+L+ + S I ME+E +L Sbjct: 444 EAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503 Query: 186 IKRVEHLKKR-VETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQ 244 K+VE L+ V+ Q+ Q +++ L EK + E + +E + +++ Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563 Query: 245 NQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAM 304 NQ S + + E+ +K +E+E K + + KE +K ++ F ++ + + Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENK-----ILHESIKETSSKLSKIEFEKRQIKKELE 618 Query: 305 GHSD----LLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360 + + ELE++++ + E N+L++KK+ + K+ Q+ S + R+ + Sbjct: 619 HYKEKGERAEELENELHHLEKE-NELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677 Query: 361 ELQEAKE---KLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQI 417 L K +L SLE+E S + D + E +R V L+ S Sbjct: 678 TLDSFKNLTFQLESLEKENS-------QLDEENL----ELRRNVESLKCAS-------MK 719 Query: 418 IAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDE 477 +A+L+ E L+ +E LK+ E ++ + E + SY ++E ++ Sbjct: 720 MAQLQLENKELESEKEQLKKGLELLKASFKKTERLE----VSYQGLDIE---------NQ 766 Query: 478 MKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAA 537 +TL++ ++ +++L S + + + ++ K L +L+ + L Q E KS + + Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS-LEQETS 825 Query: 538 GLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISS--DQQE 595 LE ++ +LE+E +RLR++ +++ N I NLE + + + E+ Y S +E Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885 Query: 596 KRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQL 645 K +E + T + + L + ++ ++ E +K +M DLE+L Sbjct: 886 LEKENKELVKRATIDIKTL---VTLREDLVSE----KLKTQQMNNDLEKL 928 Score = 72.0 bits (175), Expect = 2e-12 Identities = 113/568 (19%), Positives = 251/568 (44%), Gaps = 64/568 (11%) Query: 125 LEVPSEFLQDETVADTNKQYEELMEAFK-------TLHKEYEQLKISGFSTAEIRKDISA 177 L++ ++ LQ +T+ ++NK+ ++L + TL K E+LKIS ++ K+ + Sbjct: 761 LDIENQRLQ-KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819 Query: 178 MEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAV 237 +E+E QL K + L+K ++LR + E ++ ++ + L Sbjct: 820 LEQETSQLEKDKKQLEKE-------------NKRLRQQAEIKDTTLEENNVKIGNLEKEN 866 Query: 238 QRLQRVQNQLKS--MRQAAADAKPESLMKRLEEEIK----FNLYMVTEKFPKELENK--K 289 + L + K +R + + + L+KR +IK +V+EK + N + Sbjct: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926 Query: 290 KELHFLQKV-VSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQA 348 K H L+K+ +++ + H + +S+ + +++ ++K + E E K++ + Sbjct: 927 KLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSL---EIKEEKIAALEARL 983 Query: 349 SIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKS 408 + + +EL+ K+ +L++ ++++ R + + G++ K + Sbjct: 984 EESTNYNQQLRQELKTVKKNYEALKQ----RQDEERMVQSSPPISGEDNKWERESQETTR 1039 Query: 409 TVFKKKHQII------AELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYT- 461 + K K ++I A L+AE L+ + L+ ++ N+Q Q+ ++ + T Sbjct: 1040 ELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTT 1099 Query: 462 -QEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQE 520 Q + ++ S ++ ++ ++++ + SL +E + SVIKE L+ Y Sbjct: 1100 LQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE----SVIKEREDLKSLYDS 1155 Query: 521 LTQECDEKKSQYDSCAAGLESNRSK---LEQEVRRLREECLQEESRYHY---TNCMIKNL 574 L ++ ++ + ++ A+ ES SK L+ + L E E RY+ +++L Sbjct: 1156 LIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL 1215 Query: 575 EVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLG---KKLREKQKVIRESHGP 631 E L+ ++M + + + + +Y K E + L +L ++ +V++ H Sbjct: 1216 EKMLKVEQEKMLL-----ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDH-K 1269 Query: 632 NMKQAKMWRDLEQLMECKKQCFLKQQSQ 659 N+K LEQ + LK+Q Q Sbjct: 1270 NLKSLLNNSKLEQTRLEAEFSKLKEQYQ 1297 Score = 66.6 bits (161), Expect = 7e-11 Identities = 95/462 (20%), Positives = 193/462 (41%), Gaps = 71/462 (15%) Query: 194 KRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQA 253 KR E+ Q+ ++ +L K + L Q+ +E+ QL Q L++++ +LK ++Q Sbjct: 241 KRTESRQH------LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294 Query: 254 ----AADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDL 309 +DA+ + + + ++ V +K E+ K+ LH D+ Sbjct: 295 NMNLLSDARSARMYRDELDALREKAVRV-DKLESEVSRYKERLH--------------DI 339 Query: 310 LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQ----EA 365 ++++ E+ + L+E K M + +EG +R + K EL+ + Sbjct: 340 EFYKARVEELKEDNQVLLETKTMLEDQLEG------------TRARSDKLHELEKENLQL 387 Query: 366 KEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEF 425 K KL +E E + R + E + ++ K ++ + H L E Sbjct: 388 KAKLHDMEMERDMDRKKIEEL---------MEENMTLEMAQKQSMDESLH-----LGWEL 433 Query: 426 GLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDD 485 + RT EL + +++ ++ + + + Q + V L++ VD ++G Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI 493 Query: 486 MSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSK 545 + ++K +S+K L + I + +Q Q Q L+++ ++K+Q + L N + Sbjct: 494 LK--MEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551 Query: 546 ----LEQEVRRLRE--ECLQEESRYHYTNCMIKNLEVQ---LRRATDEMKAYISSDQQEK 596 LEQE L + L++ S+ +K++E + L + E + +S + EK Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQIS-AEARVKDIEKENKILHESIKETSSKLSKIEFEK 610 Query: 597 R--KAIREQYTKNTAEQENLGKKLR--EKQKVIRESHGPNMK 634 R K E Y + E L +L EK+ + + N+K Sbjct: 611 RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLK 652 Score = 58.5 bits (140), Expect = 2e-08 Identities = 117/629 (18%), Positives = 255/629 (40%), Gaps = 71/629 (11%) Query: 105 LLQRTNELKK-RAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKI 163 L Q T++L+K + L + +L +E ++D T+ + N + L + KTL KE K Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAE-IKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878 Query: 164 SGFSTAEIRKDISAMEEEKDQLIK-----RVEHLKKRVETAQNHQWMLKIARQLRVEKER 218 S E+ K+ + + IK R + + ++++T Q + + K+ +L Sbjct: 879 SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN 938 Query: 219 EEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPE---SLMKRLEEEIKFNLY 275 +E L +Q + R + ++++L+S + + + K E +L RLEE +N Sbjct: 939 KERLLHDEQSTDDS------RYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 992 Query: 276 MVTE-----KFPKELENKKKELHFLQKVVSEPAMGHSDLLELESK--INEINTEINQLIE 328 + E K + L+ ++ E +Q S P G + E ES+ E+ ++LIE Sbjct: 993 LRQELKTVKKNYEALKQRQDEERMVQS--SPPISGEDNKWERESQETTRELLKVKDRLIE 1050 Query: 329 KKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDG 388 + N ++ + + Q + + ++ + + SL+ + + + Q + Sbjct: 1051 VER-NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1109 Query: 389 TEVLKGDEFKRYVNK----LRSKSTVFKKKHQIIAE---LKAEFGLLQRTEELLKQRHEN 441 + +N+ L +S++ + +I E LK+ + L + E L+ HE Sbjct: 1110 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER 1169 Query: 442 IQQQLQTMEEKKGISGYSYTQ----------------------EELERVSALKSEVDEMK 479 + +++ K G ++ E+LE++ ++ E ++ Sbjct: 1170 QASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE 1229 Query: 480 GRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGL 539 + + ++ KKL + ++KE L+ ++ L + K + L Sbjct: 1230 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE----QTRL 1285 Query: 540 ESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISS-----DQQ 594 E+ SKL+++ ++L + ++ + + NLE + R D+++ + +Q Sbjct: 1286 EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1345 Query: 595 EKRKAI----REQYTKNTAEQENLGKKLREK---QKVIRESHGPNMKQAKMWRDLEQLME 647 + K + + QY E +KL EK Q + P + + + +L++ Sbjct: 1346 MESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIK 1405 Query: 648 CKKQCFLKQQSQTSIGQVIQEGGEDRLIL 676 KK ++Q ++ + E L L Sbjct: 1406 SKKDINRERQKSLTLTPTRSDSSEGFLQL 1434 Score = 34.3 bits (77), Expect = 0.39 Identities = 61/296 (20%), Positives = 123/296 (41%), Gaps = 33/296 (11%) Query: 316 INEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRK-KEAKAEELQEAKEKLASLER 374 +N++ +IN +E + + N+ + SL SI+ R+ K E LQ+ + SL Sbjct: 48 LNQVMLQINPKLESQRV-NKKVNNDASLRMHNLSILVRQIKFYYQETLQQLI--MMSLPN 104 Query: 375 EASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEEL 434 + +N E GTE E K+ + L + +KK + I ++ GL T+ Sbjct: 105 VLIIGKNPFSE-QGTE-----EVKKLLLLLLGCAVQCQKKEEFIERIQ---GLDFDTKAA 155 Query: 435 LKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLY 494 + + + + + + + + +QE++E + LK+ +K R +D+ E + + Sbjct: 156 VAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPL--LKNMALHLK-RLIDERDEHSETII 212 Query: 495 SLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLR 554 L E+ L L C + L + + ++RRLR Sbjct: 213 ELSEERDG--------LHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLR 264 Query: 555 EECLQEESRYHYTNCM--IKNLEVQLRRATDEMKAYISSDQ-----QEKRKAIREQ 603 +E EE +C ++ +E++L+R E +S + +++ A+RE+ Sbjct: 265 QEL--EEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318 >gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo sapiens] Length = 1870 Score = 88.2 bits (217), Expect = 2e-17 Identities = 118/530 (22%), Positives = 240/530 (45%), Gaps = 55/530 (10%) Query: 126 EVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQL 185 E P + L E T+ + +L ++L K E+L+ + S I ME+E +L Sbjct: 444 EAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503 Query: 186 IKRVEHLKKR-VETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQ 244 K+VE L+ V+ Q+ Q +++ L EK + E + +E + +++ Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563 Query: 245 NQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAM 304 NQ S + + E+ +K +E+E K + + KE +K ++ F ++ + + Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENK-----ILHESIKETSSKLSKIEFEKRQIKKELE 618 Query: 305 GHSD----LLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360 + + ELE++++ + E N+L++KK+ + K+ Q+ S + R+ + Sbjct: 619 HYKEKGERAEELENELHHLEKE-NELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677 Query: 361 ELQEAKE---KLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQI 417 L K +L SLE+E S + D + E +R V L+ S Sbjct: 678 TLDSFKNLTFQLESLEKENS-------QLDEENL----ELRRNVESLKCAS-------MK 719 Query: 418 IAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDE 477 +A+L+ E L+ +E LK+ E ++ + E + SY ++E ++ Sbjct: 720 MAQLQLENKELESEKEQLKKGLELLKASFKKTERLE----VSYQGLDIE---------NQ 766 Query: 478 MKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAA 537 +TL++ ++ +++L S + + + ++ K L +L+ + L Q E KS + + Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS-LEQETS 825 Query: 538 GLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISS--DQQE 595 LE ++ +LE+E +RLR++ +++ N I NLE + + + E+ Y S +E Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885 Query: 596 KRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQL 645 K +E + T + + L + ++ ++ E +K +M DLE+L Sbjct: 886 LEKENKELVKRATIDIKTL---VTLREDLVSE----KLKTQQMNNDLEKL 928 Score = 68.9 bits (167), Expect = 1e-11 Identities = 112/567 (19%), Positives = 245/567 (43%), Gaps = 63/567 (11%) Query: 125 LEVPSEFLQDETVADTNKQYEELMEAFK-------TLHKEYEQLKISGFSTAEIRKDISA 177 L++ ++ LQ +T+ ++NK+ ++L + TL K E+LKIS ++ K+ + Sbjct: 761 LDIENQRLQ-KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819 Query: 178 MEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAV 237 +E+E QL K + L+K ++LR + E ++ ++ + L Sbjct: 820 LEQETSQLEKDKKQLEKE-------------NKRLRQQAEIKDTTLEENNVKIGNLEKEN 866 Query: 238 QRLQRVQNQLKS--MRQAAADAKPESLMKRLEEEIK----FNLYMVTEKFPKELENK--K 289 + L + K +R + + + L+KR +IK +V+EK + N + Sbjct: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926 Query: 290 KELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQAS 349 K H L+K+ D + + + +++ ++K + E E K++ + Sbjct: 927 KLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSL---EIKEEKIAALEARLE 983 Query: 350 IISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKST 409 + + +EL+ K+ +L++ ++++ R + + G++ K + Sbjct: 984 ESTNYNQQLRQELKTVKKNYEALKQ----RQDEERMVQSSPPISGEDNKWERESQETTRE 1039 Query: 410 VFKKKHQII------AELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYT-- 461 + K K ++I A L+AE L+ + L+ ++ N+Q Q+ ++ + T Sbjct: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1099 Query: 462 QEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQEL 521 Q + ++ S ++ ++ ++++ + SL +E + SVIKE L+ Y L Sbjct: 1100 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE----SVIKEREDLKSLYDSL 1155 Query: 522 TQECDEKKSQYDSCAAGLESNRSK---LEQEVRRLREECLQEESRYHY---TNCMIKNLE 575 ++ ++ + ++ A+ ES SK L+ + L E E RY+ +++LE Sbjct: 1156 IKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLE 1215 Query: 576 VQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLG---KKLREKQKVIRESHGPN 632 L+ ++M + + + + +Y K E + L +L ++ +V++ H N Sbjct: 1216 KMLKVEQEKMLL-----ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDH-KN 1269 Query: 633 MKQAKMWRDLEQLMECKKQCFLKQQSQ 659 +K LEQ + LK+Q Q Sbjct: 1270 LKSLLNNSKLEQTRLEAEFSKLKEQYQ 1296 Score = 66.6 bits (161), Expect = 7e-11 Identities = 95/462 (20%), Positives = 193/462 (41%), Gaps = 71/462 (15%) Query: 194 KRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQA 253 KR E+ Q+ ++ +L K + L Q+ +E+ QL Q L++++ +LK ++Q Sbjct: 241 KRTESRQH------LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294 Query: 254 ----AADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDL 309 +DA+ + + + ++ V +K E+ K+ LH D+ Sbjct: 295 NMNLLSDARSARMYRDELDALREKAVRV-DKLESEVSRYKERLH--------------DI 339 Query: 310 LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQ----EA 365 ++++ E+ + L+E K M + +EG +R + K EL+ + Sbjct: 340 EFYKARVEELKEDNQVLLETKTMLEDQLEG------------TRARSDKLHELEKENLQL 387 Query: 366 KEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEF 425 K KL +E E + R + E + ++ K ++ + H L E Sbjct: 388 KAKLHDMEMERDMDRKKIEEL---------MEENMTLEMAQKQSMDESLH-----LGWEL 433 Query: 426 GLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDD 485 + RT EL + +++ ++ + + + Q + V L++ VD ++G Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI 493 Query: 486 MSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSK 545 + ++K +S+K L + I + +Q Q Q L+++ ++K+Q + L N + Sbjct: 494 LK--MEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551 Query: 546 ----LEQEVRRLRE--ECLQEESRYHYTNCMIKNLEVQ---LRRATDEMKAYISSDQQEK 596 LEQE L + L++ S+ +K++E + L + E + +S + EK Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQIS-AEARVKDIEKENKILHESIKETSSKLSKIEFEK 610 Query: 597 R--KAIREQYTKNTAEQENLGKKLR--EKQKVIRESHGPNMK 634 R K E Y + E L +L EK+ + + N+K Sbjct: 611 RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLK 652 Score = 58.9 bits (141), Expect = 1e-08 Identities = 120/629 (19%), Positives = 256/629 (40%), Gaps = 72/629 (11%) Query: 105 LLQRTNELKK-RAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKI 163 L Q T++L+K + L + +L +E ++D T+ + N + L + KTL KE K Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAE-IKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878 Query: 164 SGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI-ARQLRVEKEREEYL 222 S E+ E+E +L+KR K + T + K+ +Q+ + E+ + Sbjct: 879 SCVRLKEL-------EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931 Query: 223 AQQKQEQKNQLFHAVQ----RLQRVQNQLKSMRQAAADAKPE---SLMKRLEEEIKFNLY 275 ++ K +L H Q R + ++++L+S + + + K E +L RLEE +N Sbjct: 932 LEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 991 Query: 276 MVTE-----KFPKELENKKKELHFLQKVVSEPAMGHSDLLELESK--INEINTEINQLIE 328 + E K + L+ ++ E +Q S P G + E ES+ E+ ++LIE Sbjct: 992 LRQELKTVKKNYEALKQRQDEERMVQS--SPPISGEDNKWERESQETTRELLKVKDRLIE 1049 Query: 329 KKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDG 388 + N ++ + + Q + + ++ + + SL+ + + + Q + Sbjct: 1050 VER-NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108 Query: 389 TEVLKGDEFKRYVNK----LRSKSTVFKKKHQIIAE---LKAEFGLLQRTEELLKQRHEN 441 + +N+ L +S++ + +I E LK+ + L + E L+ HE Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER 1168 Query: 442 IQQQLQTMEEKKGISGYSYTQ----------------------EELERVSALKSEVDEMK 479 + +++ K G ++ E+LE++ ++ E ++ Sbjct: 1169 QASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE 1228 Query: 480 GRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGL 539 + + ++ KKL + ++KE L+ ++ L + K + L Sbjct: 1229 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE----QTRL 1284 Query: 540 ESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISS-----DQQ 594 E+ SKL+++ ++L + ++ + + NLE + R D+++ + +Q Sbjct: 1285 EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1344 Query: 595 EKRKAI----REQYTKNTAEQENLGKKLREK---QKVIRESHGPNMKQAKMWRDLEQLME 647 + K + + QY E +KL EK Q + P + + + +L++ Sbjct: 1345 MESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIK 1404 Query: 648 CKKQCFLKQQSQTSIGQVIQEGGEDRLIL 676 KK ++Q ++ + E L L Sbjct: 1405 SKKDINRERQKSLTLTPTRSDSSEGFLQL 1433 Score = 34.3 bits (77), Expect = 0.39 Identities = 61/296 (20%), Positives = 123/296 (41%), Gaps = 33/296 (11%) Query: 316 INEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRK-KEAKAEELQEAKEKLASLER 374 +N++ +IN +E + + N+ + SL SI+ R+ K E LQ+ + SL Sbjct: 48 LNQVMLQINPKLESQRV-NKKVNNDASLRMHNLSILVRQIKFYYQETLQQLI--MMSLPN 104 Query: 375 EASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEEL 434 + +N E GTE E K+ + L + +KK + I ++ GL T+ Sbjct: 105 VLIIGKNPFSE-QGTE-----EVKKLLLLLLGCAVQCQKKEEFIERIQ---GLDFDTKAA 155 Query: 435 LKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLY 494 + + + + + + + + +QE++E + LK+ +K R +D+ E + + Sbjct: 156 VAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPL--LKNMALHLK-RLIDERDEHSETII 212 Query: 495 SLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLR 554 L E+ L L C + L + + ++RRLR Sbjct: 213 ELSEERDG--------LHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLR 264 Query: 555 EECLQEESRYHYTNCM--IKNLEVQLRRATDEMKAYISSDQ-----QEKRKAIREQ 603 +E EE +C ++ +E++L+R E +S + +++ A+RE+ Sbjct: 265 QEL--EEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318 >gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 828 Score = 87.0 bits (214), Expect = 5e-17 Identities = 115/550 (20%), Positives = 254/550 (46%), Gaps = 65/550 (11%) Query: 111 ELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAE 170 ELK++ A+FL+ +V + LQ+E +Q EEL E K + K+ E++ Sbjct: 212 ELKRKLERAKFLLP-QVQTNTLQEEMW----RQEEELREQEKKIRKQEEKM---WRQEER 263 Query: 171 IRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVE----KEREEYLAQQK 226 +R+ M E+++++ ++ + L+++ + + + L+ ++LR + +E+EE + +Q+ Sbjct: 264 LREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE 323 Query: 227 Q---EQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK 283 + EQ+ +++ +RL + Q++ Q D E M +E ++ + E+ Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRD--QEERMWEQDERLREKEERMREQEKM 381 Query: 284 -ELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLS 342 E E K +E +++ + + E E K+ + + + EK+ + E K Sbjct: 382 WEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK 441 Query: 343 LYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVN 402 L+ Q+ K + + E++ E +EK+ E ++ R+ E + D+ Sbjct: 442 LWEQE------KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE--QEDQMWEQEE 493 Query: 403 KLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQ 462 K+R + + + + E L+ EE ++++ + QQ+ + EEKK TQ Sbjct: 494 KMRDQEQKMWDQEERMWEQDER---LREKEERMREQKKMWQQEEKMREEKK-------TQ 543 Query: 463 EELERVSALKSEVDEMKGRTLDDMSEMVKKL---YSLVSEKKSALASVIKELRQLRQK-- 517 E+ + K+ E K R + M E KK+ ++ E++ + +++R+ +K Sbjct: 544 EQEK-----KTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMW 598 Query: 518 -YQELTQECDEKK-SQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLE 575 +E QE +EK Q + E ++ + ++E+ +EE +QE+ + E Sbjct: 599 EQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQ------E 652 Query: 576 VQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQ 635 ++R ++M+ +Q+EK + E+ + + + +K+RE+++ +R ++ Sbjct: 653 EKMREQEEKMR-----EQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRG------QE 701 Query: 636 AKMWRDLEQL 645 KMW E++ Sbjct: 702 EKMWGQEEKM 711 Score = 81.6 bits (200), Expect = 2e-15 Identities = 96/525 (18%), Positives = 241/525 (45%), Gaps = 71/525 (13%) Query: 169 AEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKE---REEYLAQQ 225 AE+++ + E EK ++ V+ LK+++E A+ ++L + +++E +EE L +Q Sbjct: 190 AELQEKLRLAESEKSEIQLNVKELKRKLERAK---FLLPQVQTNTLQEEMWRQEEELREQ 246 Query: 226 KQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKEL 285 +++ + Q ++ +R++ Q MR+ E M+R E+ ++ + KEL Sbjct: 247 EKKIRKQEEKMWRQEERLREQEGKMREQ------EEKMRRQEKRLR--------EQEKEL 292 Query: 286 ENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYR 345 ++KEL +K+ + + E E K+ E ++ + EK ++R Sbjct: 293 REQEKELREQKKLREQ----EEQMQEQEEKMWEQEEKMREQEEK-------------MWR 335 Query: 346 QQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLR 405 Q+ + ++K+ + +E + ++ E++ ++ + R + ++ + +E + ++R Sbjct: 336 QEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIR 395 Query: 406 SKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEEL 465 + +++ + + E + + +Q+ EE + ++ E QQ + E+K+ + QE+ Sbjct: 396 EREKKMREEEETMREQEEK---MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQE 452 Query: 466 ERVSALKSEV---DEMKGRTL------------DDMSEMVKKLYSLVS----------EK 500 E++ + ++ +EM G+ D M E +K+ E+ Sbjct: 453 EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQ 512 Query: 501 KSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQE 560 L + +R+ ++ +Q+ + +EKK+Q + + + E+ +R ++ +E Sbjct: 513 DERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 572 Query: 561 ESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLRE 620 E ++ E ++R ++M Q+++ K ++ E+E+ K++E Sbjct: 573 EEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEED---KMQE 629 Query: 621 KQKVIRESHGPNMKQA-KMWRDLEQLMECKKQCFLKQQSQTSIGQ 664 +++++ E +Q KMW E++ E +++ +++Q + GQ Sbjct: 630 QEEMMWEQEEKMQEQEEKMWEQEEKMREQEEK--MREQEEKMQGQ 672 Score = 59.7 bits (143), Expect = 9e-09 Identities = 103/501 (20%), Positives = 208/501 (41%), Gaps = 99/501 (19%) Query: 179 EEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQ---QKQEQKN---- 231 E+EK + E L++ +E AQ+H ++I + E E Y +Q +K E N Sbjct: 70 EDEKKASHQHQEALRREIE-AQDHT--IRILTCQKTELETALYYSQDAARKFEDGNLGES 126 Query: 232 --------QLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK 283 +H LQR + + + + A D E L K + + LY T + Sbjct: 127 KDLAGRLHHSWHFAGELQRALSAVSTWHKKA-DRYIEELTKE-RDALSLELYRNTIT-NE 183 Query: 284 ELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSL 343 EL+ K EL L ES+ +EI + +L ++K+ R K L Sbjct: 184 ELKKKNAELQ-------------EKLRLAESEKSEIQLNVKEL-KRKLER-----AKFLL 224 Query: 344 YRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNK 403 + Q + + + + EEL+E ++K+ E + + + RE +G + ++ +R + Sbjct: 225 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKR 284 Query: 404 LRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQE 463 LR + +++ + + E K L+++ E +Q+Q + M E++ Sbjct: 285 LREQEKELREQEKELREQKK-----------LREQEEQMQEQEEKMWEQE---------- 323 Query: 464 ELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQ 523 + M E +K++ ++ L K++R+ QK + Sbjct: 324 --------------------EKMREQEEKMW----RQEERLWEQEKQMREQEQKMR---- 355 Query: 524 ECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATD 583 D+++ ++ E EQE +EE +QEE R ++ E +R + Sbjct: 356 --DQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEE 413 Query: 584 EMKAYISSDQQEKRKAIREQ----YTKNTAEQENL---GKKLREKQKVIRESHGPNMKQA 636 +M+ + +++ K ++Q + EQE + +K+ E+++ IR+ ++ Sbjct: 414 KMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEK 473 Query: 637 KMWRDLEQLMECKKQCFLKQQ 657 KMWR E++ E + Q + +++ Sbjct: 474 KMWRQ-EKMREQEDQMWEQEE 493 Score = 48.5 bits (114), Expect = 2e-05 Identities = 59/247 (23%), Positives = 110/247 (44%), Gaps = 48/247 (19%) Query: 426 GLLQRTEELLKQRHENIQQQLQTM-EEKKGISGYSY----TQEELERVSALKSEVDEMKG 480 G LQR + H+ + ++ + +E+ +S Y T EEL++ +A Sbjct: 141 GELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNA---------- 190 Query: 481 RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE 540 E+ +KL L +KS + +KEL++ ++ + L + Q + E Sbjct: 191 -------ELQEKL-RLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ--E 240 Query: 541 SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI 600 + E+++R+ E+ ++E R ++ E ++RR ++ E+ K + Sbjct: 241 EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR--------EQEKEL 292 Query: 601 REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQ--------AKMWRDLEQLMECKKQC 652 REQ K EQ KKLRE+++ ++E +Q KMWR E+L E +KQ Sbjct: 293 REQ-EKELREQ----KKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ- 346 Query: 653 FLKQQSQ 659 +++Q Q Sbjct: 347 -MREQEQ 352 Score = 38.5 bits (88), Expect = 0.021 Identities = 46/192 (23%), Positives = 86/192 (44%), Gaps = 26/192 (13%) Query: 485 DMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRS 544 D++ + + E + AL++V ++ + +ELT+E D A LE R+ Sbjct: 128 DLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERD---------ALSLELYRN 178 Query: 545 KLEQEVRRLREECLQE-----ESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQE---- 595 + E + + LQE ES +K L+ +L RA + ++ QE Sbjct: 179 TITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWR 238 Query: 596 KRKAIREQYTKNTAEQENLGK---KLREKQKVIRESHGPNMKQAKMWRD-----LEQLME 647 + + +REQ K ++E + + +LRE++ +RE +Q K R+ EQ E Sbjct: 239 QEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKE 298 Query: 648 CKKQCFLKQQSQ 659 ++Q L++Q + Sbjct: 299 LREQKKLREQEE 310 >gi|148746195 trichohyalin [Homo sapiens] Length = 1943 Score = 86.7 bits (213), Expect = 7e-17 Identities = 115/506 (22%), Positives = 231/506 (45%), Gaps = 46/506 (9%) Query: 180 EEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQR 239 +E+DQ +R E +++E + RQ R E+ERE LA+ +++ + Q + Sbjct: 115 QEEDQ--RRFEPRDRQLEEEPGQR-----RRQKRQEQERE--LAEGEEQSEKQERLEQRD 165 Query: 240 LQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVV 299 QR +L RQ + + + EE+++ TE+FP E + +++EL L++ Sbjct: 166 RQRRDEELWRQRQEWQEREER---RAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKG 222 Query: 300 SEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKA 359 E E + + E + Q E+K R ++ R++ + ++ + Sbjct: 223 RE---------EKQQQRRERQDRVFQEEEEKEWRKRE-----TVLRKEEEKLQEEEPQRQ 268 Query: 360 EELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIA 419 ELQE +E+L LER+ + Q E + + + +R + R + +++ Q Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERR 328 Query: 420 ELKAEFGLLQRTEELLKQRHENIQQQL-QTMEEKKGISGYSYTQEELERVSALKSEVDEM 478 E + E +R ++L +++ E +QQL + EE++ QEE R L+ E Sbjct: 329 EQQEE----RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR 384 Query: 479 KGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAG 538 + + L + +++ L E++ ++ +QLR++ Q+L +E +E++ + Sbjct: 385 REQQL-RREQQLRREQQLRREQQLRREQQLRREQQLRRE-QQLRREQEEERHEQKHEQER 442 Query: 539 LESNRSKLEQEVRR---LREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQE 595 E R K EQE RR REE + + + ++ E + R +++ +QQE Sbjct: 443 RE-QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501 Query: 596 KR--------KAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLME 647 +R + REQ K E+E L ++LR +Q++ RE +Q + ++L + Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE-ERREQLLKREEEKRLEQ 560 Query: 648 CKKQCFLKQQSQTSIGQVIQEGGEDR 673 +++ LK++ + Q+++ E R Sbjct: 561 ERREQRLKREQEERRDQLLKREEERR 586 Score = 85.9 bits (211), Expect = 1e-16 Identities = 96/452 (21%), Positives = 216/452 (47%), Gaps = 45/452 (9%) Query: 180 EEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQR 239 +E+++ ++++E + R E + Q ++ R+ ++ +++EE +Q++E++ Q Q+ Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQ 331 Query: 240 LQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVV 299 +R + QL+ + + + E ++R +EE + + E +E E ++++L Q++ Sbjct: 332 EERREQQLRREQ----EERREQQLRREQEEERREQQLRRE---QEEERREQQLRREQQLR 384 Query: 300 SEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKA 359 E + L E ++ E+++ R + + + L R+Q + ++E + Sbjct: 385 REQQLRREQQLRREQQLRR---------EQQLRREQQLRREQQLRREQ-QLRREQEEERH 434 Query: 360 EELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIA 419 E+ E + + L+RE +R+ + + TE + ++ +R R + +++ + Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKREEETE--RHEQERRKQQLKRDQEEERRERWLKLE 492 Query: 420 ELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMK 479 E + +R ++L +++ E +Q+L+ EE++ + ++++L R + E ++ Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE--QLL 550 Query: 480 GRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGL 539 R + E ++ L E++ ++K + RQ Q L +E +E+ Q Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQ--QRLKREQEERLEQRLK----- 603 Query: 540 ESNRSKLEQEVR---RLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEK 596 +LEQE R RL+ E +EE R ++K+ E + RR + + +QQE+ Sbjct: 604 REEVERLEQEERREQRLKREEPEEERRQQ----LLKSEEQEERR-----QQQLRREQQER 654 Query: 597 RKAIREQYTKNTAEQENLGKKL-REKQKVIRE 627 REQ K E+E L ++L RE ++ RE Sbjct: 655 ----REQRLKREEEEERLEQRLKREHEEERRE 682 Score = 85.5 bits (210), Expect = 1e-16 Identities = 108/543 (19%), Positives = 242/543 (44%), Gaps = 41/543 (7%) Query: 126 EVPSEFLQDETVA--DTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKD 183 E E+ + ETV + K EE + + L +E EQL+ E+R++ EE++ Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLR--KLERQELRRERQE-EEQQQ 297 Query: 184 QLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRV 243 Q ++R + L+++ E + Q + +Q R E++ E Q ++EQ+ + ++R Q Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE 357 Query: 244 QNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELE-NKKKELHFLQKVVSEP 302 + + + +R+ + + E ++R ++ + ++ +E + ++++L Q++ E Sbjct: 358 ERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 417 Query: 303 AMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQAS----IISRKKEAK 358 + L E + + Q ++ ++ E E + L R++ + RK++ K Sbjct: 418 QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK 477 Query: 359 AEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQII 418 ++ +E +E+ LE E ++ + RE + L+ ++ +R +L+ + + + ++ Sbjct: 478 RDQEEERRERWLKLEEEERREQQERRE----QQLRREQEERREQRLKRQEEEERLQQRLR 533 Query: 419 AELKAEFGLLQRTEELLK----QRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSE 474 +E + +R E+LLK +R E +++ + E++ +EE R LK E Sbjct: 534 SEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKRE 593 Query: 475 VDE-----MKGRTLDDMSEMVKKLYSLVSE--KKSALASVIKELRQLRQKYQELTQECDE 527 +E +K ++ + + ++ L E ++ ++K Q ++ Q+L +E E Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653 Query: 528 KKSQYDSCAAGLESNRSKLEQEVRRLREECLQE--------ESRYHYTNCMIKNLEVQLR 579 ++ Q E +LEQ ++R EE +E E I + QL Sbjct: 654 RREQ----RLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLE 709 Query: 580 RATD--EMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAK 637 D + K Y +QE ++ +EQ K + L + +E+++ R+ ++ Sbjct: 710 SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL--QWQEEERAHRQQQEEEQRRDF 767 Query: 638 MWR 640 W+ Sbjct: 768 TWQ 770 Score = 81.3 bits (199), Expect = 3e-15 Identities = 136/600 (22%), Positives = 260/600 (43%), Gaps = 73/600 (12%) Query: 107 QRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGF 166 QR EL++ R L + E+ E ++E +Q + L + K+ E+ + Sbjct: 266 QRQRELQEEEEQLRKLERQELRRERQEEE------QQQQRLRREQQLRRKQEEERREQQE 319 Query: 167 STAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKE---REEYLA 223 E ++ EE ++Q ++R E ++R + + Q + +QLR E+E RE+ L Sbjct: 320 ERREQQERREQQEERREQQLRR-EQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378 Query: 224 QQKQEQKNQLFHAVQRLQRVQ-----NQLKSMRQAAAD--AKPESLMKRLEEEIKFNLYM 276 +++Q ++ Q Q+L+R Q QL+ +Q + + E ++R +EE + Sbjct: 379 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH 438 Query: 277 VTEKFPKELENKKKELHFLQKVVSEPAMGHSD-----------------LLELES----- 314 E+ + L+ +++E K E + L+LE Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498 Query: 315 ----KINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEEL--QEAKEK 368 + ++ E + E+++ R E E +L + + R++E + E+L +E +++ Sbjct: 499 QQERREQQLRREQEERREQRLKRQEE-EERLQQRLRSEQQLRREQEERREQLLKREEEKR 557 Query: 369 LASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKK--KHQIIAELKAEFG 426 L RE +KR Q D ++LK +E +R R + ++ K + + L+ E Sbjct: 558 LEQERREQRLKREQEERRD--QLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE-- 613 Query: 427 LLQRTEELLKQR--HENIQQQLQTMEEKKGISGYSYTQEELE-RVSALKSEVDEMK-GRT 482 +R E+ LK+ E +QQL EE++ +E+ E R LK E +E + + Sbjct: 614 --ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR 671 Query: 483 LDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESN 542 L E ++ L E++ IK ++ + +L E D ++S+ S E Sbjct: 672 LKREHEEERREQELAEEEQEQARERIKS--RIPKWQWQLESEADARQSKVYSRPRKQEGQ 729 Query: 543 RSKLEQEVRRLREEC---LQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKA 599 R + EQE +R R E QEE R H + E Q R T + +A +EK + Sbjct: 730 RRRQEQEEKRRRRESELQWQEEERAHRQ----QQEEEQRRDFTWQWQA------EEKSER 779 Query: 600 IREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQ 659 R++ + +E ++LR +++ RE ++ K R ++ K+ FL+++ Q Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839 Score = 76.3 bits (186), Expect = 9e-14 Identities = 106/534 (19%), Positives = 226/534 (42%), Gaps = 71/534 (13%) Query: 122 LIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEE 181 L + E +F ++E ++ + +E + L +E + + R++ ++E Sbjct: 1423 LSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR---------KFREEEQLLQER 1473 Query: 182 KDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQK----NQLFHAV 237 ++Q + R E +K +E Q ++ RQ R K RE+ L Q+ E+K Q H Sbjct: 1474 EEQQLHRQERDRKFLEEEQ------QLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ 1527 Query: 238 QRLQR-VQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQ 296 QR ++ +Q + + RQ + + ++ EE + ++ ++ ++K L Q Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE-Q 1586 Query: 297 KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKE 356 KV + E E K E ++ + ++ +R E + +R+ ++ ++E Sbjct: 1587 KVRRQ---------EQERKFMEDEQQLRRQEGQQQLRQE----RDRKFREDEQLLQEREE 1633 Query: 357 AKAEELQ------EAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTV 410 + + E + +L ERE ++ ++ R+F E L + ++ + + + + Sbjct: 1634 QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR-QERDRK 1692 Query: 411 FKKKHQIIAELKAEFGLLQRTEELLKQ------------RHENIQQQLQTMEEKKGISGY 458 F+++ Q + + E LQ ++L +Q R E Q+QL+ E + I Sbjct: 1693 FREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEE 1752 Query: 459 SYTQEELERVSALKSEVDEMKGRTLDDMSEM--VKKLYSLVSEKKSALASVIKELRQLRQ 516 + E E + E D K R + + + ++L S S++K +E QLRQ Sbjct: 1753 EQLRPEREEQQLRRQERDR-KFREEEQLRQEREEQQLRSQESDRK------FREEEQLRQ 1805 Query: 517 KYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEV 576 + +E ++ +Y E + +LE++ +RLR QE R + E Sbjct: 1806 EREEQQLRPQQRDGKYR-----WEEEQLQLEEQEQRLR----QERDRQYRAEEQFATQEK 1856 Query: 577 QLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHG 630 R + + +QE+ + +RE++ + ++E +++ E + + HG Sbjct: 1857 SRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHG 1910 Score = 75.9 bits (185), Expect = 1e-13 Identities = 101/547 (18%), Positives = 238/547 (43%), Gaps = 53/547 (9%) Query: 130 EFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRV 189 +FL++E ++ ++L E L ++ E+ + + E R+D + +++ +R Sbjct: 832 QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR-----SQEQRRDQKWRWQLEEERKRRR 886 Query: 190 EHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKS 249 L + + + ++ ++ E +REE +++QEQ+ Q + ++LQ+ + QL Sbjct: 887 HTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQ-YREEEQLQQEEEQLLR 945 Query: 250 MRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDL 309 + + R +++++ + + P++ +++E + ++ E + Sbjct: 946 EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREE---EELQQEEEQ 1002 Query: 310 LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEE-LQEAKEK 368 L E + E + KK + E L R++ + R+++ + EE LQ+ +E+ Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQ 1062 Query: 369 LASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLL 428 L ERE ++ R++ E L+ +E +L + +++ + + + E L Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEE-----EQLLREEPEKRRRQERERQCREEEELQ 1117 Query: 429 QRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSE 488 Q E+LL++ E ++Q ELER + EV + + + L + E Sbjct: 1118 QEEEQLLREEREKRRRQ------------------ELERQYREEEEVQQEEEQLLREEPE 1159 Query: 489 MVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQ 548 ++ L +E +L+Q+ ++L +E EK+ Q + E + ++ Sbjct: 1160 ---------KRRRQELERQYREEEELQQEEEQLLREEQEKRRQ-ERERQYREEEELQRQK 1209 Query: 549 EVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNT 608 +R R+E + + ++ + E + A + K Y + E+ + + + ++ Sbjct: 1210 RKQRYRDEDQRSDLKWQW--------EPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDR 1261 Query: 609 AEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTS--IGQVI 666 Q++L L E+Q+ RE +Q E+ +E ++Q K++ + S Q++ Sbjct: 1262 QSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLL 1321 Query: 667 QEGGEDR 673 +E E++ Sbjct: 1322 REEREEK 1328 Score = 72.8 bits (177), Expect = 1e-12 Identities = 134/634 (21%), Positives = 264/634 (41%), Gaps = 101/634 (15%) Query: 107 QRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNK--QYEELMEAFKTLHKEYEQLKIS 164 +R LK+ R +K E +E + E K Q EE E + L +E E+ + Sbjct: 442 RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEE-ERREQQ 500 Query: 165 GFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKE-REEYLA 223 ++R++ EE ++Q +KR E ++ Q L+ +QLR E+E R E L Sbjct: 501 ERREQQLRRE---QEERREQRLKRQEEEERL-------QQRLRSEQQLRREQEERREQLL 550 Query: 224 QQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK 283 ++++E++ + QRL+R Q + + + + + +KR E+E + + E+ + Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR-EQEERLEQRLKREEVER 609 Query: 284 ELENKKKELHFLQKVVSEPAMGHSDLLELES----KINEINTEINQLIEKKMMRNEPIEG 339 + +++E ++ E LL+ E + ++ E + E+++ R E E Sbjct: 610 LEQEERREQRLKREEPEEER--RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEER 667 Query: 340 KLSLYRQQASIISRKKEAKAEELQEAKEKLAS--------LEREASVKRNQT----REFD 387 +++ R++E EE ++A+E++ S LE EA ++++ R+ + Sbjct: 668 LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727 Query: 388 GTEVLKGDEFKRYVNKLRSKSTVFKKKH--------------QIIAELKAEFG------- 426 G + E KR + + ++ H Q AE K+E G Sbjct: 728 GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR 787 Query: 427 ---------------LLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEEL---ERV 468 QR + L + E Q++ Q E +K + + +E+L ER Sbjct: 788 PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ-FLEEEEQLQRRERA 846 Query: 469 SALKSEVD----EMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKE--LRQLRQKYQELT 522 L+ E D + + R + K + L E+K ++ + L++ +K Q+L Sbjct: 847 QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL 906 Query: 523 QECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRAT 582 QE +E+ + + R + EQE + EE LQ+E E QL R Sbjct: 907 QEEEEELQREE------REKRRRQEQERQYREEEQLQQE-------------EEQLLREE 947 Query: 583 DEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMW--- 639 E + ++Q ++ +Q + +E ++ +E++K RE ++ ++ Sbjct: 948 REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE 1007 Query: 640 RDLEQLMECKKQCFLKQQSQTSIGQVIQEGGEDR 673 R+ + E ++Q K + Q Q+++E E R Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041 Score = 71.6 bits (174), Expect = 2e-12 Identities = 119/542 (21%), Positives = 244/542 (45%), Gaps = 63/542 (11%) Query: 142 KQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQN 201 ++ E+ E K+ ++ Q ++ + A K S +++ Q +R E +KR Sbjct: 688 EEQEQARERIKSRIPKW-QWQLESEADARQSKVYSRPRKQEGQR-RRQEQEEKRRRRESE 745 Query: 202 HQWML--KIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQ-RVQNQLKSMRQAAADAK 258 QW + RQ + E++R ++ Q + E+K++ QRL R + + RQ A+ + Sbjct: 746 LQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE--RGRQRLSARPPLREQRERQLRAEER 803 Query: 259 PESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINE 318 + + L EE + E+ ++ ++KEL FL++ + L+ E + Sbjct: 804 QQREQRFLPEEEE------KEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQ 857 Query: 319 INTEIN-------------QLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEA 365 + E QL E++ R + K +L Q RK++ + LQE Sbjct: 858 EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQ-----LRKEQ---QLLQEE 909 Query: 366 KEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEF 425 +E+L ERE ++ Q R++ E L+ +E ++ + + R K +++ Q + K Sbjct: 910 EEELQREEREKRRRQEQERQYREEEQLQQEE-EQLLREEREKRRRQERERQYRKDKK--- 965 Query: 426 GLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDD 485 L Q+ E+LL + E ++Q EKK Y +EE + + +E + R + Sbjct: 966 -LQQKEEQLLGEEPEKRRRQ---EREKK------YREEEELQQEEEQLLREEREKRRRQE 1015 Query: 486 MSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE---SN 542 +K L E++ L +E R+L+++ ++ +E E+ Q + G E Sbjct: 1016 WERQYRKKDELQQEEEQLLREE-REKRRLQERERQYREE--EELQQEEEQLLGEERETRR 1072 Query: 543 RSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQ---QEKRKA 599 R +LE++ R+ EE QEE + + + + R+ +E + +Q +E+ K Sbjct: 1073 RQELERQYRK-EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKR 1131 Query: 600 IREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQ--AKMWRDLEQLMECKKQCFLKQQ 657 R++ + E+E + +E+++++RE +Q + +R+ E+L + ++Q ++Q Sbjct: 1132 RRQELERQYREEEEV---QQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188 Query: 658 SQ 659 + Sbjct: 1189 EK 1190 Score = 65.9 bits (159), Expect = 1e-10 Identities = 112/530 (21%), Positives = 220/530 (41%), Gaps = 81/530 (15%) Query: 130 EFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRV 189 E L+ E + ++ + E + L +E E+ + + + R++ ++E ++Q ++R Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356 Query: 190 EHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKS 249 E +K E HQ Q R E E+ L +Q++E+K R Q + QL+ Sbjct: 1357 ERDRKFREEELRHQ------EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ 1410 Query: 250 MRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDL 309 R + E + R E + KF + +++ +++E FL++ H Sbjct: 1411 DRDRKF-REEEQQLSRQERDRKFR------EEEQQVRRQERERKFLEEEQQLRQERHRKF 1463 Query: 310 LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKL 369 E E + E Q + ++ + +E + L RQ+ R ++ + +EL+ + + Sbjct: 1464 REEEQLLQERE---EQQLHRQERDRKFLEEEQQLRRQE-----RDRKFREQELRSQEPER 1515 Query: 370 ASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQ 429 LE E + R Q + +F + +LR + ++ Q + +F Sbjct: 1516 KFLEEEQQLHRQQRQR----------KFLQEEQQLRRQ----ERGQQRRQDRDRKF---- 1557 Query: 430 RTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEM 489 R EE L+Q E Q Q + K + ++E ER K DE + R + ++ Sbjct: 1558 REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER----KFMEDEQQLRRQEGQQQL 1613 Query: 490 VKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQE 549 ++ E + +L Q R++ Q QE D K + + + R + EQ+ Sbjct: 1614 RQERDRKFREDE--------QLLQEREEQQLHRQERDRKFLEEEP-----QLRRQEREQQ 1660 Query: 550 VRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTA 609 +R R+ +EE + + + E QLRR QE+ + RE Sbjct: 1661 LRHDRDRKFREEEQL-----LQEGEEQQLRR-------------QERDRKFRE------- 1695 Query: 610 EQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQ 659 E++ L ++ RE++ + E + + +R+ EQL + +Q L++Q + Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQER 1745 Score = 64.7 bits (156), Expect = 3e-10 Identities = 122/604 (20%), Positives = 256/604 (42%), Gaps = 91/604 (15%) Query: 107 QRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGF 166 +R + ++R Y ++ E + L++E ++ E K L ++ EQL + Sbjct: 920 KRRRQEQERQYREEEQLQQE-EEQLLREEREKRRRQERERQYRKDKKLQQKEEQL-LGEE 977 Query: 167 STAEIRKDISAMEEEKDQLIKRVEHL-KKRVETAQNHQWMLKIARQLRVEKEREEYLAQQ 225 R++ E+++L + E L ++ E + +W + ++ +++E E+ L ++ Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037 Query: 226 KQ----EQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKF 281 ++ +++ + + + LQ+ + QL + + R EEE++ + + Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097 Query: 282 PKELENKKKELHFLQKVVSEPAMGHSDLL----------ELESKINEINTEINQLIEKKM 331 P++ +++E ++ E LL ELE + E E Q E+++ Sbjct: 1098 PEKRRRQERERQCREE--EELQQEEEQLLREEREKRRRQELERQYRE--EEEVQQEEEQL 1153 Query: 332 MRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEV 391 +R EP + + RQ+ ++ + EELQ+ +E+L E+E KR Q RE + Sbjct: 1154 LREEPEKRR----RQELE----RQYREEEELQQEEEQLLREEQE---KRRQERE---RQY 1199 Query: 392 LKGDEFKRYVNKLRSKSTVFK---------KKHQIIAELKA--------EFGLLQRTEEL 434 + +E +R K R + + +K + + K +F L+ ++ Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLR 1259 Query: 435 LKQRHENIQQQLQTMEEK---------KGISGYSYTQEELERVSALKSEVDEMKGRTLDD 485 +Q +++Q L +E+ + + +E+LER E E K R D Sbjct: 1260 DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLER-----EEQKEAKRR--DR 1312 Query: 486 MSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELT------QECDEKKSQYDSCAAGL 539 S+ K+L E+K ++ R+ Q QE QE D K + + Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEE--LRHQ 1370 Query: 540 ESNRSKLEQEVRRLREE----CLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQE 595 E R LE+E R R+E L+EE + + E QLR+ D ++E Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLR-----CQEREQQLRQDRDR------KFREE 1419 Query: 596 KRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLK 655 +++ R++ + E+E ++ ++K + E ++ + +R+ EQL++ +++ L Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479 Query: 656 QQSQ 659 +Q + Sbjct: 1480 RQER 1483 Score = 63.9 bits (154), Expect = 5e-10 Identities = 106/526 (20%), Positives = 224/526 (42%), Gaps = 77/526 (14%) Query: 180 EEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQR 239 +E++Q +++ K R E Q ++RQ R K REE ++QE++ + Q+ Sbjct: 1402 QEREQQLRQDRDRKFREEEQQ-------LSRQERDRKFREEEQQVRRQERERKFLEEEQQ 1454 Query: 240 L----------------QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFP- 282 L +R + QL + + E ++R E + KF + + P Sbjct: 1455 LRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPE 1514 Query: 283 -------KELENKKKELHFLQ--KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMR 333 ++L ++++ FLQ + + G + + K E ++ Q E++ + Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE-EEQLRQEREEQQLS 1573 Query: 334 NEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLK 393 + + K L Q+ +++ + + E +++L E + +++ + R+F E L Sbjct: 1574 RQERDRKFRLEEQKV-----RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLL 1628 Query: 394 GDEFKRYVNK-------------LRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHE 440 + ++ +++ LR + + +H + + E LLQ EE +R E Sbjct: 1629 QEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQE 1688 Query: 441 ------NIQQQLQTMEEKKGI--SGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKK 492 +QQL+ E ++ ++ELER E ++++ T + ++ Sbjct: 1689 RDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKF---REEEQLRQETEQEQLRRQER 1745 Query: 493 LYSLVSEKKSALASVIKELRQLR--QKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEV 550 ++ E++ ++LR+ +K++E Q E++ Q ES+R E+E Sbjct: 1746 YRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQ---LRSQESDRKFREEE- 1801 Query: 551 RRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQ---EKRKAIREQYTKN 607 +LR+E +++ R + + E QL+ E + D+Q E++ A +E+ + Sbjct: 1802 -QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRRE 1860 Query: 608 TAE--QENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQ 651 E QE K+ +E+++ +RE H +Q K + Q+ E K Q Sbjct: 1861 EQELWQEEEQKRRQERERKLREEH--IRRQQKEEQRHRQVGEIKSQ 1904 Score = 54.3 bits (129), Expect = 4e-07 Identities = 84/381 (22%), Positives = 162/381 (42%), Gaps = 41/381 (10%) Query: 148 MEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLK 207 +E K +E E+ + ++ + +E+D+ + E L + E Q H Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH----- 1637 Query: 208 IARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQL------KSMRQAAADAK--- 258 RQ R K EE ++QE++ QL H R R + QL + +R+ D K Sbjct: 1638 --RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695 Query: 259 PESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLE--LESKI 316 E ++R E E KF L + +ELE K +E L++ + + + LE + Sbjct: 1696 EEQQLRRQERERKF-LQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754 Query: 317 NEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREA 376 E QL ++ R E +L R++ + S++ + K E ++ ++ ERE Sbjct: 1755 LRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQ-----EREE 1809 Query: 377 SVKRNQTREFDG-----TEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRT 431 R Q R DG E L+ +E ++ + + R + ++ + Q + K+ + Sbjct: 1810 QQLRPQQR--DGKYRWEEEQLQLEEQEQRLRQERDRQ--YRAEEQFATQEKSR----REE 1861 Query: 432 EELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVK 491 +EL ++ + +Q+ + ++ I ++ +V +KS+ + GR L+ + Sbjct: 1862 QELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQ-- 1919 Query: 492 KLYSLVSEKKSALASVIKELR 512 ++ V + S L I+E R Sbjct: 1920 --FASVPVRSSPLYEYIQEQR 1938 Score = 46.2 bits (108), Expect = 1e-04 Identities = 69/329 (20%), Positives = 133/329 (40%), Gaps = 81/329 (24%) Query: 349 SIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKS 408 S++ +++ + + E +++ LE E +R Q R+ E+ +G+E +L + Sbjct: 108 SLLQDRRQEEDQRRFEPRDR--QLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165 Query: 409 TVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERV 468 +R EEL +QR Q+ Q EE++ EE + Sbjct: 166 RQ------------------RRDEELWRQR-----QEWQEREERRA--------EEEQLQ 194 Query: 469 SALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEK 528 S E +E E +++ +EL +LR+K +E Q+ ++ Sbjct: 195 SCKGHETEEFPDE------EQLRR----------------RELLELRRKGREEKQQ--QR 230 Query: 529 KSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAY 588 + + D E + + V R EE LQEE E Q +R E Sbjct: 231 RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE-------------EPQRQRELQE---- 273 Query: 589 ISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRD----LEQ 644 ++++ RK R++ + E+E ++LR +Q++ R+ +Q + R+ EQ Sbjct: 274 ---EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330 Query: 645 LMECKKQCFLKQQSQTSIGQVIQEGGEDR 673 E ++Q ++Q + Q+ +E E+R Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEER 359 >gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo sapiens] Length = 1938 Score = 85.9 bits (211), Expect = 1e-16 Identities = 116/563 (20%), Positives = 259/563 (46%), Gaps = 63/563 (11%) Query: 133 QDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHL 192 ++E ++ + L + +L ++ + L+++ ++ K+ A E + L + + L Sbjct: 933 EEEMNSELVAKKRNLEDKCSSLKRDIDDLELT---LTKVEKEKHATENKVKNLSEEMTAL 989 Query: 193 KKRVETAQNHQWMLKIARQ-----LRVEKEREEYLAQ---QKQEQKNQLFHAVQRLQRVQ 244 ++ + + L+ A Q L+VE+++ L + + ++Q + L ++++ ++++ Sbjct: 990 EENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLR 1049 Query: 245 NQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAM 304 L+ ++ K E +K +E I +L ++ ++L+ K+ EL LQ + + + Sbjct: 1050 ADLERAKR-----KLEGDLKMSQESI-MDLENDKQQIEEKLKKKEFELSQLQAKIDDEQV 1103 Query: 305 GHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQE 364 HS L+ + KI E+ I +L E IE + +L + I +++ A EL+E Sbjct: 1104 -HS--LQFQKKIKELQARIEEL-------EEEIEAEHTLRAK----IEKQRSDLARELEE 1149 Query: 365 AKEKL--ASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELK 422 E+L AS A ++ N+ RE + + ++ D + + + +T+ KK+ +AEL Sbjct: 1150 ISERLEEASGATSAQIEMNKKREAE-FQKMRRDLEEATLQHEATAATLRKKQADSVAELG 1208 Query: 423 AEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERV--------SALKSE 474 + LQR ++ L++ ++ ++ M I S ++ +ER S +K++ Sbjct: 1209 EQIDNLQRVKQKLEKEKSELKMEIDDMASN--IEALSKSKSNIERTCRTVEDQFSEIKAK 1266 Query: 475 VDEMKGRTLDDMSEMVKKLYSL-------VSEKKSALASVIKELRQLRQKYQELTQECDE 527 DE + + + D++ +L + V EK+S ++ + K + L Q+ +EL ++ +E Sbjct: 1267 -DEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEE 1325 Query: 528 KKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIK-NLEVQLRRATDEMK 586 + ++ A L+S+R + + EE +E++ + K N EV R E Sbjct: 1326 ETKAKNAMAHALQSSRHDCDLLREQYEEE---QEAKAELQRALSKANSEVAQWRTKYETD 1382 Query: 587 AYISSDQ-QEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQL 645 A +++ +E +K + ++ + E K +K + G + + RDLE+ Sbjct: 1383 AIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQG---EVEDLMRDLER- 1438 Query: 646 MECKKQCFLKQQSQTSIGQVIQE 668 C + Q + +V+ E Sbjct: 1439 --SHTACATLDKKQRNFDKVLAE 1459 Score = 79.0 bits (193), Expect = 1e-14 Identities = 108/535 (20%), Positives = 229/535 (42%), Gaps = 67/535 (12%) Query: 168 TAEIRKDISAMEEEKDQL---IKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQ 224 +AE K+++ M+E+ ++ + R E +K +E K QL+V+ E E + Sbjct: 846 SAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDA 905 Query: 225 QKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKE 284 + +R + +KS + +AK + L +RLEEE + N +V +K + Sbjct: 906 E---------------ERCEGLIKS--KILLEAKVKELTERLEEEEEMNSELVAKK--RN 946 Query: 285 LENK----KKELHFLQ----KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEP 336 LE+K K+++ L+ KV E + + L ++ + I++L ++K E Sbjct: 947 LEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEA 1006 Query: 337 IEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVK---RNQTREFDGTEVLK 393 + L + + ++ + A+ Q+ + SLE+E ++ R+ +G + Sbjct: 1007 HQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMS 1066 Query: 394 GDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKK 453 + N + KKK +++L+A+ Q +++ + +Q +++ +E Sbjct: 1067 QESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELE--- 1123 Query: 454 GISGYSYTQEELERVSALKSEVDEMK---GRTLDDMSEMVKKLYSLVSEKKSALASVIKE 510 EE+E L++++++ + R L+++SE +++ S + E Sbjct: 1124 ---------EEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAE 1174 Query: 511 LRQLRQKYQELTQECDE-----KKSQYDSCAA------GLESNRSKLEQEVRRLREECLQ 559 +++R+ +E T + + +K Q DS A L+ + KLE+E L+ E Sbjct: 1175 FQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDD 1234 Query: 560 EESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKR--KAIREQYTKNTAEQENLGKK 617 S + N+E R D+ + D+Q+ + + Q + + L + Sbjct: 1235 MASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHR 1294 Query: 618 LREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGED 672 + EK+ +I S KQA +QL E K+Q + +++ ++ +Q D Sbjct: 1295 VEEKESLI--SQLTKSKQAL----TQQLEELKRQMEEETKAKNAMAHALQSSRHD 1343 Score = 73.9 bits (180), Expect = 4e-13 Identities = 110/478 (23%), Positives = 213/478 (44%), Gaps = 88/478 (18%) Query: 144 YEELMEAFKTLHKEY-----------EQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHL 192 YEE+++ +TL +E EQ+ +G + E K +E+EK L +E + Sbjct: 1492 YEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEV 1551 Query: 193 KKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQ 252 + +E + ++ LRV+ E L+Q K E ++ + ++ QLK Q Sbjct: 1552 EGSLEHEE--------SKILRVQLE----LSQVKSELDRKVIEKDEEIE----QLKRNSQ 1595 Query: 253 AAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLEL 312 AA E+L L+ EI+ + + K++E E+ E +GHS+ Sbjct: 1596 RAA----EALQSVLDAEIRSRNDAL--RLKKKMEGDLNEM--------EIQLGHSNRQMA 1641 Query: 313 ESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASL 372 E++ + T QL + ++ ++ + L ++Q +I+ R+ EEL+E K L Sbjct: 1642 ETQ-KHLRTVQGQLKDSQLHLDDALRSNEDL-KEQLAIVERRNGLLLEELEEMKVALEQT 1699 Query: 373 EREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQI-IAELKAEFGLLQRT 431 ER TR E+L + + ++ + KKK + IA+ +AE Sbjct: 1700 ER--------TRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEV------ 1745 Query: 432 EELLKQRHENIQQQLQTMEE--KKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEM 489 EN Q+ + EE KK I+ + EEL++ + ++ MK ++ + Sbjct: 1746 --------ENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK----KNLEQT 1793 Query: 490 VKKLYSLVSE-KKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQ 548 VK L + E ++ AL K++++L + +EL E D ++ + G E+ + + Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKR------GAEALKGAHKY 1847 Query: 549 EVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTK 606 E R+++E Q E + KN+ ++L+ D+++A + S +++ +A + T+ Sbjct: 1848 E-RKVKEMTYQAEEDH-------KNI-LRLQDLVDKLQAKVKSYKRQAEEAEEQANTQ 1896 Score = 48.9 bits (115), Expect = 2e-05 Identities = 68/285 (23%), Positives = 122/285 (42%), Gaps = 55/285 (19%) Query: 396 EFKRYVNKLRSKSTVFKKKHQIIAELKAE----FGLLQRTEELLKQRHENIQQQLQTMEE 451 EFK+ + + + ++F ++ I + + + L + + LLK ++++ TM+E Sbjct: 804 EFKKMMER---RDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEA--EKEMATMKE 858 Query: 452 KKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKEL 511 + T+EEL R A + E++E K+ SL+ EK V E Sbjct: 859 D-----FERTKEELARSEARRKELEE--------------KMVSLLQEKNDLQLQVQSET 899 Query: 512 RQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMI 571 L + + C+ GL ++ LE +V+ L E +EE Sbjct: 900 ENL----MDAEERCE-----------GLIKSKILLEAKVKELTERLEEEEEMNSELVAKK 944 Query: 572 KNLE---VQLRRATDEMKAYISSDQQEKRKAIREQYTKN-----TAEQENLGKKLREKQK 623 +NLE L+R D+++ ++ + EK K E KN TA +EN+ K +EK K Sbjct: 945 RNLEDKCSSLKRDIDDLE--LTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEK-K 1001 Query: 624 VIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQE 668 ++E+H + ++ D + K L+QQ+ G + QE Sbjct: 1002 SLQEAHQQTLDDLQVEEDKVNGL-IKINAKLEQQTDDLEGSLEQE 1045 Score = 38.9 bits (89), Expect = 0.016 Identities = 66/337 (19%), Positives = 140/337 (41%), Gaps = 55/337 (16%) Query: 111 ELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYE--QLKISGF-- 166 E++ R R K+E ++ + + +N+Q E + +T+ + + QL + Sbjct: 1608 EIRSRNDALRLKKKMEGDLNEMEIQ-LGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALR 1666 Query: 167 STAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQ-----NHQWMLKIARQLRV------- 214 S ++++ ++ +E L++ +E +K +E + + Q +L + ++++ Sbjct: 1667 SNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTS 1726 Query: 215 ----EKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPES--------L 262 +K+ E +AQ + E +N + + ++ + + A + K E + Sbjct: 1727 LINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1786 Query: 263 MKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSE-----------PAMGHSDLLE 311 K LE+ +K + + E L+ KK++ L+ V E A + Sbjct: 1787 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHK 1846 Query: 312 LESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLAS 371 E K+ E+ + + K ++R + + KL QA + S K++ AEE +E S Sbjct: 1847 YERKVKEMTYQAEE-DHKNILRLQDLVDKL-----QAKVKSYKRQ--AEEAEEQANTQLS 1898 Query: 372 LEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKS 408 R + + E + D + VNKLR+KS Sbjct: 1899 RCRRVQHELEEAAE-------RADIAESQVNKLRAKS 1928 Score = 35.0 bits (79), Expect = 0.23 Identities = 27/114 (23%), Positives = 52/114 (45%), Gaps = 16/114 (14%) Query: 149 EAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI 208 EA K HK ++K + E K+I +++ D+L +V+ K++ E A+ Q ++ Sbjct: 1839 EALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAE-EQANTQL 1897 Query: 209 ARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESL 262 +R RV+ E EE A +R ++Q+ +R + D + + Sbjct: 1898 SRCRRVQHELEE---------------AAERADIAESQVNKLRAKSRDVGSQKM 1936 >gi|237858621 polyamine modulated factor 1 binding protein 1 isoform b [Homo sapiens] Length = 882 Score = 83.2 bits (204), Expect = 7e-16 Identities = 118/611 (19%), Positives = 261/611 (42%), Gaps = 84/611 (13%) Query: 106 LQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISG 165 L+ +E K+ + + ++KLE+ L++ET A ++ +++ L ++L++ Sbjct: 191 LEAVSEQKRN--IMKDMMKLELDLHGLREETSAHIERKDKDIT----ILQCRLQELQLEF 244 Query: 166 FSTAEIRKDISAMEEEKDQ---------------LIKRVEHLKKRVETAQNHQWMLKIAR 210 T ++ +EKD+ L+K+ + L+K+ A + +K A+ Sbjct: 245 TETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAK 304 Query: 211 QLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADA--KPESLMKRLEE 268 Q + ++ + L + Q+ KN L A Q+ + Q ++ AA A E ++L++ Sbjct: 305 QDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQK 364 Query: 269 EIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLI- 327 + ++ ++ ++ ++EL LQK E +M + ++ E++ E+++ + Sbjct: 365 GL-----LLDKQKADTIQELQRELQMLQK---ESSMAEKEQTSNRKRVEELSLELSEALR 416 Query: 328 -----------------EKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLA 370 E+ M N+ ++ +R+Q SI K E+LQEA + L Sbjct: 417 KLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI----KCKLEEDLQEATKLLE 472 Query: 371 SLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQR 430 + + + +G EFK+ L+ S +++++ L+AE Sbjct: 473 DKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE---NLRAELQCCST 529 Query: 431 TEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMV 490 E ++ QQ +Q + ++ + S + + AL+ E ++ + + Sbjct: 530 QLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQ-------TTIT 582 Query: 491 KKLYSLVSEKKSA----LASVIKELRQLRQKYQELTQ---ECDEKKSQYDSCAAGLESNR 543 K+ Y +S K +A L +++L + + + L Q + EKK+Q + E Sbjct: 583 KEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERM 642 Query: 544 SKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQL----RRATDEMKAYISSDQQEKRKA 599 KL E+R+LR + E H + ++ + Q+ ++ +++K + ++Q Sbjct: 643 KKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQ----- 697 Query: 600 IREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQ-- 657 +RE + A +ENL + +K+ +++R +Q+M +Q + KQQ Sbjct: 698 LREFQEEMAALKENLLED--DKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQ-WAKQQKV 754 Query: 658 SQTSIGQVIQE 668 + +G ++E Sbjct: 755 ANEKLGNQLRE 765 Score = 71.6 bits (174), Expect = 2e-12 Identities = 102/472 (21%), Positives = 207/472 (43%), Gaps = 70/472 (14%) Query: 215 EKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNL 274 E E + + + QEQK+ V+ Q + L+ +A ++ K ++MK + + ++ +L Sbjct: 155 ECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQK-RNIMKDMMK-LELDL 212 Query: 275 YMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLEL---ESKINEINTEINQLIEKKM 331 + + E+ +E K K++ LQ + E + ++ +L + K + E+ Q +EKK+ Sbjct: 213 HGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKL 272 Query: 332 --MRNEPIEGKLSLYRQQASIISRK---KEAKAE------------ELQEAKEKLASLER 374 ++N ++ + L +QQ + KEAK + E+Q+ K L ++ Sbjct: 273 TQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQ 332 Query: 375 EASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQ----- 429 + + Q + L G + KL+ + K+K I EL+ E +LQ Sbjct: 333 QERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSM 392 Query: 430 ----------RTEELLKQRHENIQQQLQTMEEKKGISGYSYTQ-----EELERVSALKSE 474 R EEL + E +++ + +EK+ + Q + L+R+ E Sbjct: 393 AEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHRE 452 Query: 475 VDEMKGRTLDDMSEMVKKL------YSLVSEKKSALASVIKELRQ--------LRQKYQE 520 +K + +D+ E K L E + + ++ LRQ L++ ++ Sbjct: 453 QGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRK 512 Query: 521 LTQECDEKKSQYDSCAAGLESNRSKL---EQEVRRLREE-CLQEESRYHYTNCMIKNLEV 576 L +E + +++ C+ LES+ +K +Q ++ L +E LQ+ES + +L+ Sbjct: 513 LEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKES--------LMSLQA 564 Query: 577 QLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRES 628 QL +A + K Y+ + ++A K+ A Q++L + L + V E+ Sbjct: 565 QLDKALQKEKHYLQT--TITKEAYDALSRKSAACQDDLTQALEKLNHVTSET 614 Score = 67.0 bits (162), Expect = 5e-11 Identities = 105/560 (18%), Positives = 227/560 (40%), Gaps = 60/560 (10%) Query: 154 LHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNH------QWMLK 207 LH EQL ++G A + + ++ ++ + +E L+ +V+ Q Q Sbjct: 12 LHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPEN 71 Query: 208 IARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKR-- 265 +V + Q+ QE + +L Q++ + + ++ +R A + L + Sbjct: 72 KGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKA 131 Query: 266 -LEEEIKFNLYMVTEKFP----KELENKKKELHFLQ------------------------ 296 ++ + F T ++P +E E+ KK L LQ Sbjct: 132 LIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVEL 191 Query: 297 KVVSEPAMG-HSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKK 355 + VSE D+++LE ++ + E + IE+K ++ +L + + + + Sbjct: 192 EAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLT 251 Query: 356 EAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKH 415 K + LQE E L LE++ + +N + + E+ K + ++ K K Sbjct: 252 LKKDKFLQEKDEMLQELEKKLTQVQNSLLKKE-KELEKQQCMATELEMTVKEAKQDKSKE 310 Query: 416 QIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISG--YSYTQEELERVSALKS 473 L+AE L+ + E KQ+ QQ +E+ ++G TQ +L++ L Sbjct: 311 AECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLL-- 368 Query: 474 EVDEMKGRTLDDMS---EMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKS 530 D+ K T+ ++ +M++K S+ +++++ ++EL + + D++K Sbjct: 369 --DKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKR 426 Query: 531 QYDSCAAGLESNRSKLEQEVRRLREE-----CLQEESRYHYTNCMIKNLEVQLRRATDEM 585 Q A + + + ++ E C EE T ++++ QL+++ + Sbjct: 427 QLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATK-LLEDKREQLKKSKEHE 485 Query: 586 KAY------ISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMW 639 K + + ++K K ++E K E ENL +L+ + S ++ Sbjct: 486 KLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVI 545 Query: 640 RDLEQLMECKKQCFLKQQSQ 659 +DL + + +K+ + Q+Q Sbjct: 546 QDLNKEIALQKESLMSLQAQ 565 >gi|237858619 polyamine modulated factor 1 binding protein 1 isoform a [Homo sapiens] Length = 1007 Score = 83.2 bits (204), Expect = 7e-16 Identities = 118/611 (19%), Positives = 261/611 (42%), Gaps = 84/611 (13%) Query: 106 LQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISG 165 L+ +E K+ + + ++KLE+ L++ET A ++ +++ L ++L++ Sbjct: 336 LEAVSEQKRN--IMKDMMKLELDLHGLREETSAHIERKDKDIT----ILQCRLQELQLEF 389 Query: 166 FSTAEIRKDISAMEEEKDQ---------------LIKRVEHLKKRVETAQNHQWMLKIAR 210 T ++ +EKD+ L+K+ + L+K+ A + +K A+ Sbjct: 390 TETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAK 449 Query: 211 QLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADA--KPESLMKRLEE 268 Q + ++ + L + Q+ KN L A Q+ + Q ++ AA A E ++L++ Sbjct: 450 QDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQK 509 Query: 269 EIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLI- 327 + ++ ++ ++ ++EL LQK E +M + ++ E++ E+++ + Sbjct: 510 GL-----LLDKQKADTIQELQRELQMLQK---ESSMAEKEQTSNRKRVEELSLELSEALR 561 Query: 328 -----------------EKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLA 370 E+ M N+ ++ +R+Q SI K E+LQEA + L Sbjct: 562 KLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI----KCKLEEDLQEATKLLE 617 Query: 371 SLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQR 430 + + + +G EFK+ L+ S +++++ L+AE Sbjct: 618 DKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE---NLRAELQCCST 674 Query: 431 TEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMV 490 E ++ QQ +Q + ++ + S + + AL+ E ++ + + Sbjct: 675 QLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQ-------TTIT 727 Query: 491 KKLYSLVSEKKSA----LASVIKELRQLRQKYQELTQ---ECDEKKSQYDSCAAGLESNR 543 K+ Y +S K +A L +++L + + + L Q + EKK+Q + E Sbjct: 728 KEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERM 787 Query: 544 SKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQL----RRATDEMKAYISSDQQEKRKA 599 KL E+R+LR + E H + ++ + Q+ ++ +++K + ++Q Sbjct: 788 KKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQ----- 842 Query: 600 IREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQ-- 657 +RE + A +ENL + +K+ +++R +Q+M +Q + KQQ Sbjct: 843 LREFQEEMAALKENLLED--DKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQ-WAKQQKV 899 Query: 658 SQTSIGQVIQE 668 + +G ++E Sbjct: 900 ANEKLGNQLRE 910 Score = 71.6 bits (174), Expect = 2e-12 Identities = 102/472 (21%), Positives = 207/472 (43%), Gaps = 70/472 (14%) Query: 215 EKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNL 274 E E + + + QEQK+ V+ Q + L+ +A ++ K ++MK + + ++ +L Sbjct: 300 ECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQK-RNIMKDMMK-LELDL 357 Query: 275 YMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLEL---ESKINEINTEINQLIEKKM 331 + + E+ +E K K++ LQ + E + ++ +L + K + E+ Q +EKK+ Sbjct: 358 HGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKL 417 Query: 332 --MRNEPIEGKLSLYRQQASIISRK---KEAKAE------------ELQEAKEKLASLER 374 ++N ++ + L +QQ + KEAK + E+Q+ K L ++ Sbjct: 418 TQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQ 477 Query: 375 EASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQ----- 429 + + Q + L G + KL+ + K+K I EL+ E +LQ Sbjct: 478 QERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSM 537 Query: 430 ----------RTEELLKQRHENIQQQLQTMEEKKGISGYSYTQ-----EELERVSALKSE 474 R EEL + E +++ + +EK+ + Q + L+R+ E Sbjct: 538 AEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHRE 597 Query: 475 VDEMKGRTLDDMSEMVKKL------YSLVSEKKSALASVIKELRQ--------LRQKYQE 520 +K + +D+ E K L E + + ++ LRQ L++ ++ Sbjct: 598 QGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRK 657 Query: 521 LTQECDEKKSQYDSCAAGLESNRSKL---EQEVRRLREE-CLQEESRYHYTNCMIKNLEV 576 L +E + +++ C+ LES+ +K +Q ++ L +E LQ+ES + +L+ Sbjct: 658 LEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKES--------LMSLQA 709 Query: 577 QLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRES 628 QL +A + K Y+ + ++A K+ A Q++L + L + V E+ Sbjct: 710 QLDKALQKEKHYLQT--TITKEAYDALSRKSAACQDDLTQALEKLNHVTSET 759 Score = 68.6 bits (166), Expect = 2e-11 Identities = 111/590 (18%), Positives = 238/590 (40%), Gaps = 66/590 (11%) Query: 124 KLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKD 183 KL+ L +E + + N+ E LH EQL ++G A + + ++ ++ Sbjct: 133 KLKEDEVILYEEEMGNHNENTGE------KLHLAQEQLALAGDKIASLERSLNLYRDKYQ 186 Query: 184 QLIKRVEHLKKRVETAQNH------QWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAV 237 + +E L+ +V+ Q Q +V + Q+ QE + +L Sbjct: 187 SSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVW 246 Query: 238 QRLQRVQNQLKSMRQAAADAKPESLMKR---LEEEIKFNLYMVTEKFP----KELENKKK 290 Q++ + + ++ +R A + L + ++ + F T ++P +E E+ KK Sbjct: 247 QKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKK 306 Query: 291 ELHFLQ------------------------KVVSEPAMG-HSDLLELESKINEINTEINQ 325 L LQ + VSE D+++LE ++ + E + Sbjct: 307 ILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSA 366 Query: 326 LIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTRE 385 IE+K ++ +L + + + + K + LQE E L LE++ + +N + Sbjct: 367 HIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLK 426 Query: 386 FDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQ 445 + E+ K + ++ K K L+AE L+ + E KQ+ QQ Sbjct: 427 KE-KELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQ 485 Query: 446 LQTMEEKKGISG--YSYTQEELERVSALKSEVDEMKGRTLDDMS---EMVKKLYSLVSEK 500 +E+ ++G TQ +L++ L D+ K T+ ++ +M++K S+ ++ Sbjct: 486 AAQCKEEAALAGCHLEDTQRKLQKGLLL----DKQKADTIQELQRELQMLQKESSMAEKE 541 Query: 501 KSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREE---- 556 +++ ++EL + + D++K Q A + + + ++ E Sbjct: 542 QTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI 601 Query: 557 -CLQEESRYHYTNCMIKNLEVQLRRATDEMKAY------ISSDQQEKRKAIREQYTKNTA 609 C EE T ++++ QL+++ + K + + ++K K ++E K Sbjct: 602 KCKLEEDLQEATK-LLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEE 660 Query: 610 EQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQ 659 E ENL +L+ + S ++ +DL + + +K+ + Q+Q Sbjct: 661 ENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQ 710 Score = 54.3 bits (129), Expect = 4e-07 Identities = 102/539 (18%), Positives = 214/539 (39%), Gaps = 85/539 (15%) Query: 208 IARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMK--- 264 ++ QL ++ + Q+K Q NQL ++ N +QA A A ES ++ Sbjct: 20 LSLQLDIKNLHDVCKRQRKTLQDNQLC-----MEEAMNSSHDKKQAQALAFEESEVEFGS 74 Query: 265 ------RLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINE 318 R +++K L ++ ++ E + + L++ S SDL+ L Sbjct: 75 SKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKL 134 Query: 319 INTEINQLIEKKMMRNEPIEGKLSLYRQQASI-------ISRKKEAKAEELQEAKEKLAS 371 E+ E+ NE KL L ++Q ++ + R ++ Q + + Sbjct: 135 KEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIEL 194 Query: 372 LEREASVKRNQTREFDGTE-VLKGDEFKRYV----------------------------- 401 LE + + + + G E KGD K + Sbjct: 195 LECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDD 254 Query: 402 ------NKLRSKSTVFKKKHQIIAELKAEFGLLQRTEEL---LKQRHENIQQQLQTMEEK 452 NKL + + ++ + + +L+A+F T + E+I++ L+ ++E+ Sbjct: 255 LIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQ 314 Query: 453 KGISGYSYTQEELERVSALKSE---VDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIK 509 K S + +E V L+ E V E K + DM ++ L+ L E + + K Sbjct: 315 KD-SQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDK 373 Query: 510 ELRQLRQKYQELTQECDEKKS---QYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHY 566 ++ L+ + QEL E E + + D + +LE+++ +++ L++E Sbjct: 374 DITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEK 433 Query: 567 TNCMIKNLEVQLRRA----------------TDEMKAYISSDQQEKRKAIREQYTKNTAE 610 CM LE+ ++ A ++K + +Q++R A +Q + E Sbjct: 434 QQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLA-AQQAAQCKEE 492 Query: 611 QENLGKKLREKQKVIRESHGPNMKQAKMWRDLE-QLMECKKQCFLKQQSQTSIGQVIQE 668 G L + Q+ +++ + ++A ++L+ +L +K+ + ++ QTS + ++E Sbjct: 493 AALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEE 551 >gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] Length = 1411 Score = 82.8 bits (203), Expect = 9e-16 Identities = 122/616 (19%), Positives = 255/616 (41%), Gaps = 87/616 (14%) Query: 48 KQLVDIREEMPEQTAKRMLSLLGI------LKYKPSGNATDMSTFRQGLVIGSKPVIYPV 101 K+LV ++ M T +R + L+ + + + +S R L G + V V Sbjct: 228 KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV 287 Query: 102 --LHWLLQRTNEL-KKRAYLARFLIKLEVPSEFLQD----ETVADTN------------K 142 L L NEL +K L L+K E L++ E+V+ N + Sbjct: 288 QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ 347 Query: 143 QYEELMEAFKT-LHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQN 201 Q + + A +T LH+ + +L G +T ++++++S +E + +HLK Sbjct: 348 QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVET-------KYQHLKAEF----- 395 Query: 202 HQWMLKIARQLRVEKEREEYLAQQKQEQKNQ----LFHAVQRLQRVQNQLKSMRQAAADA 257 +QL+ ++E +E Q Q + NQ L ++L +LK RQ ++ Sbjct: 396 --------KQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSS-- 445 Query: 258 KPESLMKRLEE--EIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESK 315 E LM + ++ +++ L + E+ +++ N + H L K + + +K Sbjct: 446 --EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAK 503 Query: 316 INEINTEINQLIEK---KMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASL 372 + E ++ Q++ + K + + +E L ++ S++ +++E ++Q + + A L Sbjct: 504 LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL 563 Query: 373 EREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTE 432 + ++N T + T++ ++ N+ S + H + E KA Q Sbjct: 564 NQ--LQEKNHTLQEQVTQLT-----EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 616 Query: 433 ELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKK 492 L+ + QL +EK S +++ + L + K D+ + Sbjct: 617 LSLETSVNELNSQLNESKEK-----VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDT 671 Query: 493 LYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKS---QYDSCAAGLESNRSKLEQE 549 + + +K+ L + +L Q+ K Q+ + C + +S +Y LE +LE + Sbjct: 672 AQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQ 731 Query: 550 VRRL----------REECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISS---DQQEK 596 +++L +E+ LQ+ + N ++ +L + + K +SS D Q+K Sbjct: 732 IKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791 Query: 597 RKAIREQYTKNTAEQE 612 +A+ K T ++E Sbjct: 792 SEALESIKQKLTKQEE 807 Score = 79.3 bits (194), Expect = 1e-14 Identities = 90/493 (18%), Positives = 208/493 (42%), Gaps = 62/493 (12%) Query: 132 LQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVE- 190 LQ T A + +L + + + + ++++ + +++IS +E+E++ L +++ Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555 Query: 191 ---------HLKKRVETAQNHQWML--KIARQLRVEKEREEYLAQQKQEQKNQLFHAVQR 239 L+++ T Q L K+ Q K+ +E L Q QEQK L A R Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615 Query: 240 LQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFP---------------KE 284 + ++ + + ++K + ++ + K L + E Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675 Query: 285 LENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKM---MRNEPIEGKL 341 L++K++EL+ K+ ++ + L + + +++ + + + EK + + E +EG++ Sbjct: 676 LQDKQQELN---KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI 732 Query: 342 SLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYV 401 + + KE ++LQ+ ++ LE A TE+ K E ++ + Sbjct: 733 KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRA------------TELSKQLEMEKEI 780 Query: 402 NKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYT 461 + S +KK + + +K + + +++LKQ E + Q+ + E+ + T Sbjct: 781 --VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELN-NRIQTT 837 Query: 462 QEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQEL 521 EL++V K + + ++S + KL + K++ + KE ++ + +L Sbjct: 838 VTELQKVKMEKEAL-------MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDL 890 Query: 522 TQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRA 581 + C E K Q L+ +E + L++ +E+ H + +++ QL +A Sbjct: 891 EKTCKELKHQ-------LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQA 943 Query: 582 TDEMKAYISSDQQ 594 + +K +QQ Sbjct: 944 QNTLKQNEKEEQQ 956 Score = 74.7 bits (182), Expect = 3e-13 Identities = 104/538 (19%), Positives = 222/538 (41%), Gaps = 72/538 (13%) Query: 135 ETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKK 194 + V D +E + L KE E K G E + D + + ++ L++ Sbjct: 90 QEVQDLQASLKEEKWYSEELKKELE--KYQGLQQQEAKPDGLVTDSSAE-----LQSLEQ 142 Query: 195 RVETAQNHQWMLKIARQLRVEKERE-----EYLAQQKQEQKNQLFHAVQRLQRVQNQLKS 249 ++E AQ + +K + L +K + + + E+++ A Q++ R+ +L Sbjct: 143 QLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNK 202 Query: 250 MRQAAADAKPESLMKRLEEEIKF-------------NLYMVTEKFPKELENKKKELHF-- 294 D K E L + E++ N+ + E+ ++L+++ K+L Sbjct: 203 EATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQY 262 Query: 295 -------------LQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKL 341 L K E A+ +L +L+S +NE+ T+ NQ + + +++ E KL Sbjct: 263 ASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL-TQKNQTLTENLLKKEQDYTKL 321 Query: 342 SLYRQQASIISRKKEA----KAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEF 397 + S+ + +A K + Q+ + +L++ E + E KG+ Sbjct: 322 EEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSE-------KGEA- 373 Query: 398 KRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISG 457 KL+ + + + K+Q LKAEF LQ+ E +Q +Q ++ + K Sbjct: 374 ---TQKLKEELSEVETKYQ---HLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK----- 422 Query: 458 YSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQK 517 T+ +L E ++ L D + V L +S + L + +L+ + Sbjct: 423 LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482 Query: 518 YQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLRE--------ECLQEESRYHYTNC 569 + Q+ E+++ S A L ++ LEQ +R++ + E L ++S+ + + Sbjct: 483 LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLL 542 Query: 570 MIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRE 627 + ++ + E + + + QEK ++EQ T+ T + +N + ++ Q+ + + Sbjct: 543 EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600 Score = 70.1 bits (170), Expect = 6e-12 Identities = 114/564 (20%), Positives = 236/564 (41%), Gaps = 82/564 (14%) Query: 114 KRAYLARFLIKLEVPSEFLQD--ETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEI 171 K+ L + +L+ + LQD E + +E E + +L ++ E+L+ Sbjct: 679 KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD 738 Query: 172 RKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKN 231 ++ A +E+ Q +++ L +E ++++QL +EKE Q++ Sbjct: 739 SLEVKASKEQALQDLQQQRQLNTDLELRAT-----ELSKQLEMEKEIVSSTRLDLQKKSE 793 Query: 232 QLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLE-------------------EEIKF 272 L Q+L + + + + ++Q E+ ++ E E + Sbjct: 794 ALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMT 853 Query: 273 NLYMVTEKFPK---ELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEK 329 L V +K K L+N K E E G + +L+LE E+ ++ +E Sbjct: 854 ELSTVKDKLSKVSDSLKNSKSEFE------KENQKGKAAILDLEKTCKELKHQLQVQMEN 907 Query: 330 KMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREA--------SVKRN 381 + + ++ L ++ + + + + E+L +A+ L E+E +K++ Sbjct: 908 TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967 Query: 382 QTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAE---FGLLQ----RTEEL 434 ++ E L+G+ + K ++ + ++ Q EL AE +LQ +++E Sbjct: 968 SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027 Query: 435 LKQRHENI----------QQQLQTMEEKKGISGYSYTQEEL----ERVSALKSEVDEMKG 480 KQ + +Q L+++EEK S QE+L ++ + E+K Sbjct: 1028 FKQLQSDFYGRESELLATRQDLKSVEEK-----LSLAQEDLISNRNQIGNQNKLIQELKT 1082 Query: 481 RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE 540 + KK L E+ AL + KE + L++K EL E K ++ + E Sbjct: 1083 AKATLEQDSAKKEQQL-QERCKALQDIQKE-KSLKEK--ELVNE-KSKLAEIEEIKCRQE 1137 Query: 541 SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKR--K 598 +KL +E++ + E ++E + ++ +++L+ D +KA + +QEKR + Sbjct: 1138 KEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAV---EQEKRNQQ 1194 Query: 599 AIREQYTKNTAEQENLGKKLREKQ 622 +++Q K E+E L K+ EK+ Sbjct: 1195 ILKDQVKK---EEEELKKEFIEKE 1215 Score = 69.3 bits (168), Expect = 1e-11 Identities = 99/498 (19%), Positives = 208/498 (41%), Gaps = 55/498 (11%) Query: 123 IKLEVPSEFLQDETVADT-NKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDIS-AMEE 180 +K+E + + TV D +K + L + KE ++ K + + K++ ++ Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903 Query: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIA-RQLRVEKEREEYLAQQKQEQKNQLFHAVQR 239 + + +K + LKK +E + LK+ ++ + + + +Q ++++ QL + Sbjct: 904 QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963 Query: 240 LQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVV 299 L++ Q K +A +++++ E E K + + +EL +K+++ LQ Sbjct: 964 LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLT--QAAQELAAEKEKISVLQNNY 1021 Query: 300 SEPAMG----HSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKK 355 + SD ES++ ++ + EK + E + + Q +I K Sbjct: 1022 EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELK 1081 Query: 356 EAKA----------EELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLR 405 AKA ++LQE + L +++E S+K + + +++ + +E K K Sbjct: 1082 TAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVN-EKSKLAEIEEIKCRQEKEI 1140 Query: 406 SKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEEL 465 +K K H++ E E L+ ++LL IQQ+L+ + K S + ++E Sbjct: 1141 TKLNEELKSHKL--ESIKEITNLKDAKQLL------IQQKLEL--QGKADSLKAAVEQEK 1190 Query: 466 ERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKK---------------------SAL 504 LK +V + + + E KL+S + EK+ L Sbjct: 1191 RNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENL 1250 Query: 505 ASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRY 564 +V KE + +++ EL ++ D+ + + A +++N + E R L E CL+ E Sbjct: 1251 GTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNN----QDERRALLERCLKGEGEI 1306 Query: 565 HYTNCMIKNLEVQLRRAT 582 + L+ +L T Sbjct: 1307 EKLQTKVLELQRKLDNTT 1324 Score = 67.8 bits (164), Expect = 3e-11 Identities = 111/528 (21%), Positives = 226/528 (42%), Gaps = 71/528 (13%) Query: 124 KLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKD 183 +LE+ E + T D K+ E L + L K+ E+ +I +++D + +E Sbjct: 773 QLEMEKEIVSS-TRLDLQKKSEALESIKQKLTKQEEEKQI-------LKQDFETLSQET- 823 Query: 184 QLIKRVEH--LKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQ 241 +++H L R++T +L+ K +E L + K++L L+ Sbjct: 824 ----KIQHEELNNRIQTT---------VTELQKVKMEKEALMTELSTVKDKLSKVSDSLK 870 Query: 242 RVQNQLKSMRQA--AADAKPESLMKRLEEEIKF---NLYMVTEKFPKELENKKKELHFLQ 296 +++ + Q AA E K L+ +++ N ++ K LE +K+ H L+ Sbjct: 871 NSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLK 930 Query: 297 ----KVVSEPAMGHSDLLELESKINEINTEINQL---IEKKMMRNEPIEGKLSLYRQQAS 349 + + + L + E + ++ IN+L E+K + E ++G+L + Q + Sbjct: 931 LELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKT 990 Query: 350 IISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKST 409 + K + ++L +A ++LA+ + + SV +N + T FK+ + + + Sbjct: 991 ELENKLQ---QQLTQAAQELAAEKEKISVLQNNYEKSQET-------FKQLQSDFYGRES 1040 Query: 410 VFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVS 469 Q + ++ + L Q E+L+ R++ I Q + ++E K + LE+ S Sbjct: 1041 ELLATRQDLKSVEEKLSLAQ--EDLISNRNQ-IGNQNKLIQELKT------AKATLEQDS 1091 Query: 470 ALKSEVDEMKGRTLDDMS-EMVKKLYSLVSEKKSALASVI-------KELRQLRQKYQEL 521 A K + + + + L D+ E K LV+EK S LA + KE+ +L ++ + Sbjct: 1092 AKKEQQLQERCKALQDIQKEKSLKEKELVNEK-SKLAEIEEIKCRQEKEITKLNEELKSH 1150 Query: 522 TQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRA 581 E ++ + L + +L+ + L+ QE+ +K E +L++ Sbjct: 1151 KLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKE 1210 Query: 582 TDEMKAYISSDQQEKRKAIREQYTKN-------TAEQENLGKKLREKQ 622 E +A + S+ +EK +++ TA ENLG +E Q Sbjct: 1211 FIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQ 1258 Score = 58.9 bits (141), Expect = 1e-08 Identities = 61/314 (19%), Positives = 144/314 (45%), Gaps = 24/314 (7%) Query: 366 KEKLASLEREASVKRNQTREFDGT---EVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELK 422 + LA + ++ R + ++ + E +E K+ + K + K ++ + Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134 Query: 423 AEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRT 482 AE L++ E + + NI+Q E+K + ++ +KS+ DE + Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAA--------QLATEIADIKSKYDEERS-- 184 Query: 483 LDDMSEMVKKLYSLVSEKKSALASVIKELR-QLRQKYQELTQECDEKKSQYDSCAAGLES 541 + E ++ + ++E+ + A+VI++L+ +L Q+ ++ K + +++ Sbjct: 185 ---LREAAEQKVTRLTEELNKEATVIQDLKTELLQRPG--IEDVAVLKKELVQVQTLMDN 239 Query: 542 NRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIR 601 + E+E +L++EC + +S+Y + I L +L + E+ Y+ + Q+ + ++ Sbjct: 240 MTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV-QELQKLKSSVN 298 Query: 602 EQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQL-MECKKQCFLKQQSQT 660 E KN ENL KK ++ K+ + + ++ + + L Q ++C++ S+T Sbjct: 299 ELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASET 358 Query: 661 SIGQV---IQEGGE 671 S+ ++ + E GE Sbjct: 359 SLHRIHVELSEKGE 372 Score = 57.8 bits (138), Expect = 3e-08 Identities = 103/491 (20%), Positives = 220/491 (44%), Gaps = 64/491 (13%) Query: 214 VEKEREEYLAQQKQEQ--KNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIK 271 + +E ++ A K+E+ +L +++ Q +Q Q +AKP+ L+ E++ Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQ---------EAKPDGLVTDSSAELQ 138 Query: 272 FNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKM 331 + E + K+ + F QK A +++ +++SK +E + + E+K+ Sbjct: 139 SLEQQLEEAQTENFNIKQMKDLFEQKA----AQLATEIADIKSKYDE-ERSLREAAEQKV 193 Query: 332 MRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAK-EKLASLEREA----SVKRNQTREF 386 R + +L+ ++A++I ++ K E LQ E +A L++E ++ N T E Sbjct: 194 TR---LTEELN---KEATVI---QDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLER 244 Query: 387 DGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQL 446 + DE K+ ++ S + +A+ E + + + LK + Q+ Sbjct: 245 ERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKN 304 Query: 447 QTMEEK--KGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSAL 504 QT+ E K Y+ +E+ S K + TL ++L S +S +++L Sbjct: 305 QTLTENLLKKEQDYTKLEEKHNEESVSKKNIQA----TLHQKDLDCQQLQSRLSASETSL 360 Query: 505 ASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRY 564 + EL + E TQ+ E+ S+ ++ L++ +L+Q+ + LQ +S Sbjct: 361 HRIHVELSEKG----EATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEI 416 Query: 565 HYTNCMIKNLEVQLRRATDEMK--AYISSDQ---QEKRKA------------IREQYTKN 607 + + + E QL A +K +SS++ +E++ A ++E+ T + Sbjct: 417 NQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNS 476 Query: 608 TAEQENLG--KKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQV 665 T Q L K+ ++Q+ +++S +++A+ DLEQ++ +Q K Q ++ + Sbjct: 477 TELQHQLDKTKQQHQEQQALQQSTTAKLREAQ--NDLEQVL---RQIGDKDQKIQNLEAL 531 Query: 666 IQEGGEDRLIL 676 +Q+ E+ +L Sbjct: 532 LQKSKENISLL 542 >gi|109255234 centrosomal protein 290kDa [Homo sapiens] Length = 2479 Score = 82.4 bits (202), Expect = 1e-15 Identities = 109/508 (21%), Positives = 223/508 (43%), Gaps = 64/508 (12%) Query: 111 ELKKRAY-LARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTA 169 ELKKR L ++ + +D V D + Q L E L K++ + S S + Sbjct: 1988 ELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSIS 2047 Query: 170 EIRKDISAMEEE---KDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQK 226 I D E+ K+ L E+++ + + Q ++ + ++ Q+R KE E+L ++K Sbjct: 2048 GIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEK 2107 Query: 227 QEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEI--------KFNLYMVT 278 E + +L H V+ +S + K LMK++ E++ K + + + Sbjct: 2108 AEVQRKLGH-------VRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTS 2160 Query: 279 EKFPK-ELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEI--NQLIEKKMMRNE 335 EK E EN+K + L+K+ + +GH + ESK I N+ + K++ + Sbjct: 2161 EKMANIEQENEKLKAE-LEKLKAH--LGHQLSMHYESKTKGTEKIIAENERLRKELKKET 2217 Query: 336 PIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGD 395 KL + + I++ K + EE + + S R ++ ++ + V + Sbjct: 2218 DAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAES--RGPQLEGADSKSWKSIVVTR-- 2273 Query: 396 EFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGI 455 Y KL+ T KK+Q I +LK E+ + + +E+++QQ++ ++ Sbjct: 2274 ---MYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILK----- 2325 Query: 456 SGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEK-KSALASVIKELRQL 514 + E E LK E+ ++ E + ++ + + K +S S I + QL Sbjct: 2326 ----HVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQL 2381 Query: 515 RQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQ---------EESRYH 565 ++K ++L E K S + + L++E+++L++E E+ +Y+ Sbjct: 2382 KEKIKDL--ETQLKMSDLE---------KQHLKEEIKKLKKELENFDPSFFEEIEDLKYN 2430 Query: 566 YTNCMIKN--LEVQLRRATDEMKAYISS 591 Y + KN LE ++++ ++++ ++S Sbjct: 2431 YKEEVKKNILLEEKVKKLSEQLGVELTS 2458 Score = 66.6 bits (161), Expect = 7e-11 Identities = 121/596 (20%), Positives = 241/596 (40%), Gaps = 77/596 (12%) Query: 129 SEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKR 188 + FL++E + KQ E+ + + KE E+ K ++ + ++ EE + + Sbjct: 110 TRFLRNE-ICQLEKQLEQKDRELEDMEKELEKEK-------KVNEQLALRNEEAENENSK 161 Query: 189 VEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQ--KNQLFHAVQRLQRVQNQ 246 + KR++ I Q +++ ++E L+++ ++ ++QL L + ++ Sbjct: 162 LRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDE 221 Query: 247 LKSMRQA--AADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAM 304 ++++ +A + + + + K LEE ++ EK E K +H V+ Sbjct: 222 IQTLTEANEKIEVQNQEMRKNLEESVQ-----EMEKMTDEYNRMKAIVHQTDNVI----- 271 Query: 305 GHSDLLELESKINEINT-EINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQ 363 D L+ E+ ++ E+ L++ K ++PI ++ ++ +I K+ + E Q Sbjct: 272 ---DQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQ 328 Query: 364 EA----KEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIA 419 + +EKL + + +A K N G + + + K ++ + +K II Sbjct: 329 QMLHNLREKLKNAQLDAD-KSNVMALQQGIQE-RDSQIKMLTEQVEQYTKEMEKNTCIIE 386 Query: 420 ELKAEFGLLQRTEELLKQRHENIQQQLQTMEEK-------KGISGYSYTQEELERVSALK 472 +LK E + L +Q H IQ L ++EK ++ +++ E V ALK Sbjct: 387 DLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALK 446 Query: 473 SEVDEMKG-RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECD----- 526 D G L+D +K + + + + + KE+ +L K + E + Sbjct: 447 RLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRER 506 Query: 527 ---EKKSQYDSC----AAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLR 579 E K+ D + L+ + + E ++ E L+EE E R Sbjct: 507 VGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKR 566 Query: 580 RATD-------EMKAYISSDQQEKRKAIREQYTKNTAE----QENLGKKLREKQKVIRES 628 AT + IS + + + KN +E E L ++L EK++ + S Sbjct: 567 SATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERS 626 Query: 629 HGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQE--------GGEDRLIL 676 AK L++L+E KQ ++ I Q I+E GGE LI+ Sbjct: 627 ---RTVIAKFQNKLKELVEENKQL---EEGMKEILQAIKEMQKDPDVKGGETSLII 676 Score = 64.3 bits (155), Expect = 3e-10 Identities = 136/627 (21%), Positives = 248/627 (39%), Gaps = 149/627 (23%) Query: 147 LMEAFKT-LHKEYEQLKISGFSTAEIRKDISAMEEEK--------------DQLIKR-VE 190 L+E K+ L + +Q K + E+R +++A EE+ Q++ R Sbjct: 1726 LVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTR 1785 Query: 191 HLKKRVETAQNHQWMLKIARQLRVEKEREEYLA----------QQKQEQKNQLFHAVQRL 240 LK +VE + +LK+ L+ K RE L Q+KQ+ N++ + + Sbjct: 1786 ELKTQVEDLNEN--LLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEI 1843 Query: 241 QRVQNQLKSMRQ---AAADAKP-----ESLMKRLEEEIK------------FNLYMVTEK 280 + ++LK + + KP +SL++ L+ ++K +L + EK Sbjct: 1844 DQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEK 1903 Query: 281 FPKE---------------------LENKKKELHFLQKVVSEP----AMGHSDLLELESK 315 KE L+ K+ E+ L K ++ A + L L+ K Sbjct: 1904 NAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRK 1963 Query: 316 INEINTEINQL-----------IEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQE 364 + ++Q+ +E+ RN +E + LY + + R + LQ Sbjct: 1964 LKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDI-LYMRAHQALPRDSVVEDLHLQN 2022 Query: 365 --AKEKLASLEREASVKRNQTREFDGTE----VLKGDEFKRYVNKLRSKSTVFK----KK 414 +EKL +LE++ S G E + E ++ KL S++ K + Sbjct: 2023 RYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQA 2082 Query: 415 HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSE 474 ++ + LK + L+ E LK+ +Q++L + +G T ELE+ L + Sbjct: 2083 NKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHV---RGSGRSGKTIPELEKTIGLMKK 2139 Query: 475 VDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKS-QYD 533 V E R +E +KK +++ +K +A++ +E +L+ + ++L + S Y+ Sbjct: 2140 VVEKVQRE----NEQLKKASGILTSEK--MANIEQENEKLKAELEKLKAHLGHQLSMHYE 2193 Query: 534 SCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQ 593 S G E K+ E RLR+E +E NLE+ Sbjct: 2194 SKTKGTE----KIIAENERLRKELKKETDAAEKLRIAKNNLEI----------------- 2232 Query: 594 QEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQA--KMWRDL-------EQ 644 + E K T + E GK+L+ ES GP ++ A K W+ + + Sbjct: 2233 ------LNE---KMTVQLEETGKRLQ-----FAESRGPQLEGADSKSWKSIVVTRMYETK 2278 Query: 645 LMECKKQCFLKQQSQTSIGQVIQEGGE 671 L E + K QS T + Q+++E E Sbjct: 2279 LKELETDIAKKNQSITDLKQLVKEATE 2305 Score = 62.0 bits (149), Expect = 2e-09 Identities = 89/444 (20%), Positives = 187/444 (42%), Gaps = 56/444 (12%) Query: 212 LRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIK 271 + + K L +KQE LF R+ L M+ + E + K EE+ K Sbjct: 30 ISLSKVEVNELKSEKQENVIHLF-------RITQSLMKMKAQEVELALEEVEKAGEEQAK 82 Query: 272 FNLYMVTE--KFPKELENKK-----KELHFLQKVVS--EPAMGHSDLLELESKINEINTE 322 F + T+ K ELE + ++ FL+ + E + D ELE E+ E Sbjct: 83 FENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKD-RELEDMEKELEKE 141 Query: 323 INQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQ 382 ++ E+ +RNE E + S R++ + +K E +++ + ++++ S + +R + Sbjct: 142 -KKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGE 200 Query: 383 TREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENI 442 ++ K E +Y++++++ + +K + + +E+ K E++ Sbjct: 201 DSDYRSQLSKKNYELIQYLDEIQTLTEANEK-------------IEVQNQEMRKNLEESV 247 Query: 443 QQQLQTMEEKKGISGYSYTQEELERVSALKSE-----------VDEMKGRTLDDMSEMVK 491 Q+ + +E + + + + + LK E D +K + +D MV Sbjct: 248 QEMEKMTDEYNRMKAIVHQTDNV--IDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMV- 304 Query: 492 KLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYD---SCAAGLESNRSKLEQ 548 + + V E K L+S E+ + +Q L ++ K +Q D S L+ + + Sbjct: 305 AVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKL--KNAQLDADKSNVMALQQGIQERDS 362 Query: 549 EVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNT 608 +++ L E+ Q C+I++L+ +L+R ++ + +S K ++ + + T Sbjct: 363 QIKMLTEQVEQYTKEMEKNTCIIEDLKNELQR--NKGASTLSQQTHMKIQSTLDILKEKT 420 Query: 609 AEQENLGK----KLREKQKVIRES 628 E E + REK K + E+ Sbjct: 421 KEAERTAELAEADAREKDKELVEA 444 Score = 59.3 bits (142), Expect = 1e-08 Identities = 119/597 (19%), Positives = 233/597 (39%), Gaps = 107/597 (17%) Query: 105 LLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYE-QLKI 163 L++ E+K YL + + E L++E V NK +EE A+ + E QL I Sbjct: 1365 LVKDKEEIK---YLNNIISEYERTISSLEEEIVQQ-NKFHEERQMAWDQREVDLERQLDI 1420 Query: 164 SGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKERE---E 220 EI EE + L ++E A + KI +R+ E + Sbjct: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIA-----LRKIKENIRIILETRATCK 1475 Query: 221 YLAQQKQEQKNQLFHAVQRL---QRVQNQLKSMRQAAADAKP---ESLMKRLEEEIKFNL 274 L ++ +E+++ L A Q + +V N+L+ A A+ + E K +E + L Sbjct: 1476 SLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTL 1535 Query: 275 YM-----------------VTEKFPKELENKKKELHFLQKVVSEPA--MGHSDLLELESK 315 + V +K+ + LE ++E + K E + H L+ +S Sbjct: 1536 KIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSS 1595 Query: 316 INEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLERE 375 +N+ L+ K+ P + ++ + ++ + L + K+ LER+ Sbjct: 1596 LNKFKQTAWDLM-KQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQ 1654 Query: 376 ASVKRNQTREFDGTEVLKGDEFKRYVNKLRS-------------------KSTVFKKK-- 414 + + +EF+ ++ + + V K+++ KS + +K Sbjct: 1655 REITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEA 1714 Query: 415 ---------HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEEL 465 ++ LK++ L ++ ++ L + ++ ++ E++ IS S + L Sbjct: 1715 NSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHL 1774 Query: 466 ERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQ------ 519 + E+K + ++D++E + KL + K+ S+ L L + Q Sbjct: 1775 NVQQIVDRHTRELKTQ-VEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAY 1833 Query: 520 --------ELTQECDEKKSQYDSCAAGLE-----SNRSKLEQEVRRLREECLQEESRYHY 566 E+ QE DE K Q +GL+ N+ L +E++R Sbjct: 1834 NKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQR-------------- 1879 Query: 567 TNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIR-EQYTKNTAEQENLGKKLREKQ 622 +K LE QL +E+ ++ K + IR E+ K A+ E + KL+EK+ Sbjct: 1880 ---KVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKE 1933 Score = 58.2 bits (139), Expect = 3e-08 Identities = 115/570 (20%), Positives = 235/570 (41%), Gaps = 104/570 (18%) Query: 98 IYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKE 157 I L L ++T E ++ A LA AD ++ +EL+EA K L K+ Sbjct: 409 IQSTLDILKEKTKEAERTAELAE-----------------ADAREKDKELVEALKRL-KD 450 Query: 158 YE------------------QLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETA 199 YE Q+KI + K+I+ +E + + E L++RV Sbjct: 451 YESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERV--G 508 Query: 200 QNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQ-LFHAVQRLQRVQNQLKS-MRQAAADA 257 + M+ + E ++L QQ+ +NQ L ++ L+ + LK +RQ A + Sbjct: 509 LEPKTMIDLT-----EFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQER 563 Query: 258 KPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKIN 317 S L E NL TE + +++L L ++ E +SK Sbjct: 564 GKRSATSGLTTE-DLNL---TENISQGDRISERKLDLLSL---------KNMSEAQSKNE 610 Query: 318 EINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREAS 377 ++ E+ + E+ + R+ + K + ++ K+ + E ++E + + ++++ Sbjct: 611 FLSRELIEK-ERDLERSRTVIAKFQ--NKLKELVEENKQLE-EGMKEILQAIKEMQKDPD 666 Query: 378 VKRNQTREFDGTEVLKGDEFKRYVNKLRSKST--VFKKKHQIIAELKAEFGLLQRTEELL 435 VK +T L +R VN + SK+ +F + A++ G R EEL Sbjct: 667 VKGGETS-------LIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTG---RNEELR 716 Query: 436 KQRHENIQQQLQTMEEKKGISGYSYTQEELERVSAL--KSEVDEMKGRTLDDMSEMVKKL 493 ++ E+ ++ + ++ ++ + + LE+ ++L +SE + + +D + Sbjct: 717 QELRESRKEAINYSQQ---LAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSS 773 Query: 494 YSLVSEKKSALASVIKELRQLRQKYQELTQECDEKK--------------SQYDSCAAGL 539 S+++ + L +++EL +K + L ++ +Y S Sbjct: 774 ASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETW 833 Query: 540 ESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQ------ 593 ++ +++E R+L ++ Q+ + N ++ L++ +DEMK ++ + Sbjct: 834 KTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMD----SDEMKKILAENSRKITVL 889 Query: 594 QEKRKAIREQYTKNTAEQENLGKKLREKQK 623 Q K++ QYT E E +K EKQK Sbjct: 890 QVNEKSLIRQYT-TLVELERQLRKENEKQK 918 Score = 57.0 bits (136), Expect = 6e-08 Identities = 105/575 (18%), Positives = 238/575 (41%), Gaps = 81/575 (14%) Query: 117 YLARFLIKLEVPSEFLQ--DETVADTNKQYEELMEAFKTLHKEY---------------- 158 YL L +LE + L+ ++++ D N+++ + L+KEY Sbjct: 783 YLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKE 842 Query: 159 ------EQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQL 212 +Q++ E ++A++ + D++ K + +++ Q ++ + RQ Sbjct: 843 EKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNE--KSLIRQY 900 Query: 213 RVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKF 272 E E L ++ ++QKN+L + L+ ++ A K +L K ++ + Sbjct: 901 TTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAI-FKIAALQKVVDNSVSL 959 Query: 273 NLYMVTEKFPKELENKKKEL----HFLQKVVSEPAMGHSDLLELESKINEINTEINQLIE 328 + + K EL K +++ + L + S + + L+ ++ IN E+ ++ + Sbjct: 960 SELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKEL-EITK 1018 Query: 329 KKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDG 388 +K+ E + + ++S+ KK ++ +K+ LE + +R Sbjct: 1019 EKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQ------- 1071 Query: 389 TEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQT 448 + + ++ LR T K+ + EL+ +F EL K + Q+++ Sbjct: 1072 ----RAEHCQKMYEHLR---TSLKQMEERNFELETKFA------ELTKINLD--AQKVEQ 1116 Query: 449 MEEKKGISGYSYTQEELERVSALKSEVDEMKGRT----LDDMSEMVKKLYSLVSEKKSAL 504 M + S + +R L+ E +EM+ + L ++S++ ++ +++ ++ Sbjct: 1117 MLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQ-- 1174 Query: 505 ASVIKELRQLRQKYQELTQECDEKK------------SQYDSCAAG-LESNRSKLEQEVR 551 S KE+ LR + + + DEK ++ A G LES SKL++ Sbjct: 1175 -SRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEA 1233 Query: 552 ---RLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNT 608 RL ++ ++E +Y +N LR+ ++ S A +E+++K Sbjct: 1234 YNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSG---ALPLAQQEKFSKTM 1290 Query: 609 AEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLE 643 + +N K+ ++ K ++ H NM+ + +L+ Sbjct: 1291 IQLQNDKLKIMQEMKNSQQEH-RNMENKTLEMELK 1324 Score = 55.5 bits (132), Expect = 2e-07 Identities = 93/439 (21%), Positives = 178/439 (40%), Gaps = 60/439 (13%) Query: 145 EELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQW 204 +E K L ++ EQ T E+ K+ +E+ K++L + +T Q Sbjct: 358 QERDSQIKMLTEQVEQY------TKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQS 411 Query: 205 MLKIARQLRVEKEREEYLAQQKQEQKN-QLFHAVQRLQRVQNQLKSMRQAAADAKPESLM 263 L I ++ E ER LA+ +K+ +L A++RL+ ++ + + A + + Sbjct: 412 TLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVE------I 465 Query: 264 KRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINE-INTE 322 K + +IK + +E+ L K +++ + SD L+ + E + E Sbjct: 466 KNCKNQIKI---------------RDREIEILTKEINKLELKISDFLDENEALRERVGLE 510 Query: 323 INQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQ 382 +I+ RN K YR + I+ ++ E+ EE + K+K+ + +E KR+ Sbjct: 511 PKTMIDLTEFRNSK-HLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERG-KRSA 568 Query: 383 TREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEF---GLLQRTEELLKQRH 439 T ++ + + K + K+ A+ K EF L+++ +L + R Sbjct: 569 TSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRT 628 Query: 440 --ENIQQQLQTM-EEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSL 496 Q +L+ + EE K + +E L+ + ++ + D G T S ++ L L Sbjct: 629 VIAKFQNKLKELVEENKQLE--EGMKEILQAIKEMQKDPDVKGGET----SLIIPSLERL 682 Query: 497 VSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREE 556 V+ +S A I + K+Q D L +L QE+R R+E Sbjct: 683 VNAIESKNAEGIFDASL-------------HLKAQVDQ----LTGRNEELRQELRESRKE 725 Query: 557 CLQEESRYHYTNCMIKNLE 575 + + N I +LE Sbjct: 726 AINYSQQLAKANLKIDHLE 744 Score = 48.1 bits (113), Expect = 3e-05 Identities = 102/566 (18%), Positives = 236/566 (41%), Gaps = 83/566 (14%) Query: 141 NKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVET-A 199 NKQY EL ++ + ++ L + + + +++E+ + + K +E K+++ T Sbjct: 966 NKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIE 1025 Query: 200 QNHQWMLKIARQLRVEKEREE--------------YLAQQKQEQKNQLFHAVQRLQRVQN 245 Q + K+ + ++K ++ L ++ ++ + H + + ++ Sbjct: 1026 QAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRT 1085 Query: 246 QLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMG 305 LK M + + L + E K NL +K + L ++ + + K VS+ Sbjct: 1086 SLKQMEE-----RNFELETKFAELTKINL--DAQKVEQMLRDELAD--SVSKAVSD--AD 1134 Query: 306 HSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEA 365 +LELE E+ E+++L E + R+Q I++ +++++ +E++ Sbjct: 1135 RQRILELEKNEMELKVEVSKLREIS-----------DIARRQVEILNAQQQSRDKEVESL 1183 Query: 366 KEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEF 425 + +L + ++ K + L+ E + KL S ++ +K L+ + Sbjct: 1184 RMQLLDYQAQSDEKSLIAKLHQHNVSLQLSE-ATALGKLESITSKLQKMEAYNLRLEQK- 1241 Query: 426 GLLQRTEELL-------KQRHENIQQQLQTM------------EEKKGISGYSYTQEELE 466 L E+ L + R ++++Q +Q++ +EK + ++L+ Sbjct: 1242 --LDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLK 1299 Query: 467 RVSALKSEVDE---MKGRTLDDMSEMVKKLYSLVSEKKSALAS--VIK---ELRQLRQKY 518 + +K+ E M+ +TL +M +K L L+S K + VI ++ +LR + Sbjct: 1300 IMQEMKNSQQEHRNMENKTL-EMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQE 1358 Query: 519 QELTQEC--DEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEV 576 +L +E D+++ +Y L + S+ E+ + L EE +Q+ + EV Sbjct: 1359 LKLNRELVKDKEEIKY------LNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREV 1412 Query: 577 QLRRATD----EMKAYISSDQ--QEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHG 630 L R D + +++ Q +E +I + + E +K++E ++I E+ Sbjct: 1413 DLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRA 1472 Query: 631 PNMKQAKMWRDLEQLMECKKQCFLKQ 656 + ++ E + +Q L + Sbjct: 1473 TCKSLEEKLKEKESALRLAEQNILSR 1498 >gi|34577114 cytomatrix protein p110 [Homo sapiens] Length = 957 Score = 82.0 bits (201), Expect = 2e-15 Identities = 123/584 (21%), Positives = 252/584 (43%), Gaps = 65/584 (11%) Query: 126 EVPSEFLQ--DETVADTNKQYEELMEAFKTLHKEYE---------QLKISGFSTAEIRKD 174 +VPS Q D T+ D Q +EL L KE + I F + E++K+ Sbjct: 134 QVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKE 193 Query: 175 ISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIAR-QLRVEKEREEYLAQQKQEQKNQL 233 +EE ++ E ++ E Q+ Q ++ + +LR +++ +L QQ+ + Sbjct: 194 RVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLN-HLLQQESGNRGAE 252 Query: 234 FHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELH 293 ++ + +N + + AK L+++ EE++ + + E+ KK L Sbjct: 253 HFTIELTE--ENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLE 310 Query: 294 FLQ------KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQ 347 LQ K + + + E ES+++ + ++Q ++ + E + + L + Sbjct: 311 MLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEP 370 Query: 348 ASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKL--- 404 A K +A ++ K+ASLER ++ + VL ++ + + ++ Sbjct: 371 A-----KTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVY 425 Query: 405 RSKSTVFKKK----HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSY 460 +S S K K Q +++ ++E LQ E L ++ + +Q ++ ++E S Sbjct: 426 KSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKE-------SL 478 Query: 461 TQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSL--VSEKKSALASVIKELRQ----- 513 T +E +R + L++EVD ++ R + S + KK L ++E+K LA I++++ Sbjct: 479 TAKE-QRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVK 537 Query: 514 ------LRQKYQELTQECDEKKSQYDSC---AAGLESNRSKLEQEVRRLREECLQEESRY 564 L++K + L ++ +K Q + L+++ S + + L EE L E+ R Sbjct: 538 ERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATL-EEALSEKER- 595 Query: 565 HYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKV 624 +I+ L+ Q R E I S ++E K ++E+ AE L + ++ Sbjct: 596 -----IIERLKEQRERDDRERLEEIESFRKE-NKDLKEKVNALQAELTEKESSLIDLKEH 649 Query: 625 IRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQE 668 +K+ + LE +E KK+ K ++Q I++ Sbjct: 650 ASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIED 693 >gi|58530840 desmoplakin isoform I [Homo sapiens] Length = 2871 Score = 81.6 bits (200), Expect = 2e-15 Identities = 121/548 (22%), Positives = 236/548 (43%), Gaps = 59/548 (10%) Query: 146 ELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWM 205 E +A K E E+L++ ++++ + E +++L K H + + +N Sbjct: 1159 ESEKAIKEKEYEIERLRVL------LQEEGTRKREYENELAKVRNHYNEEMSNLRN---- 1208 Query: 206 LKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKR 265 K ++ + K + ++ QK++ L + + RL R LK D S+++ Sbjct: 1209 -KYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLND----SILQA 1263 Query: 266 LEEEIKFNLYMVTEKF-PKELENKKKELHFLQKVV----SEPAMGHSDLLELESK-INEI 319 E+ + + +K E+ KK+ L K V SE H LE +K I + Sbjct: 1264 TEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDK 1323 Query: 320 NTEINQL---IEKKMMRNEPIEGKLSLYRQQ--ASIISRKKEAKAEELQEAKEKLASL-- 372 N EI +L +++ R E +LS R IIS K + + E + K + L Sbjct: 1324 NKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETE-INITKTTIHQLTM 1382 Query: 373 --EREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQR 430 E + S R Q +E KR N L + ++ + I + KA + + Sbjct: 1383 QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQ 1442 Query: 431 TEELLKQRHENIQQQL--QTMEEKKGISGYSYT-QEELERVSALKSEVDEMKG--RTLDD 485 ++ L+ + Q +++ K+ + + T Q++ + + LK +D+ + L+D Sbjct: 1443 RKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLED 1502 Query: 486 MSEMVKKL-YSLVSEKKSALASVIK------ELRQLRQKYQELTQEC---DEKKSQYDSC 535 + ++++ Y L SA ++ K EL +LR Y+ ++QE D+ +++ + Sbjct: 1503 ENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNS 1562 Query: 536 AAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQL---RRATDEMKAYISS- 591 L+ + K+E+E+ RL+ ++ +C K LE +L RR+ E I++ Sbjct: 1563 LKELQLQKQKVEEELNRLKRTASED-------SCKRKKLEEELEGMRRSLKEQAIKITNL 1615 Query: 592 -DQQEKRKAIREQYTKNTAEQEN-LGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECK 649 Q E+ ++++ + +Q + L LREKQ+ E + + + R L Q E Sbjct: 1616 TQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESV 1675 Query: 650 KQCFLKQQ 657 KQ L+ + Sbjct: 1676 KQAHLRNE 1683 Score = 76.3 bits (186), Expect = 9e-14 Identities = 113/524 (21%), Positives = 235/524 (44%), Gaps = 51/524 (9%) Query: 124 KLEVPSEFLQDETVADTNKQYEELMEAFKTL---HKEYEQLKISGFSTAEIRKDISAMEE 180 +LEV + ++ + + L +A KT+ +KE E+LK RK + E Sbjct: 1446 QLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCL----E 1501 Query: 181 EKDQLIKRVEH-LKKRVETAQNHQWMLKIARQ----LRVEKEREEYLAQQKQEQKNQLFH 235 +++ ++RV++ L+K +A LK+ Q LR++ ER K + + + Sbjct: 1502 DENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQN 1561 Query: 236 AVQRLQ----RVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK--ELENKK 289 +++ LQ +V+ +L +++ A++ + K+LEEE++ + E+ K L + Sbjct: 1562 SLKELQLQKQKVEEELNRLKRTASEDSCKR--KKLEEELEGMRRSLKEQAIKITNLTQQL 1619 Query: 290 KELHFLQKVVSEPAMGHSDLLE--------LESKINEINTEINQLIEKKMMRNEPIEGKL 341 ++ ++K + D+L+ + ++ +++E+ L + + E + K Sbjct: 1620 EQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESV--KQ 1677 Query: 342 SLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYV 401 + R + + E K+ L E+K +ER S+ N T+E E + Y Sbjct: 1678 AHLRNEH--FQKAIEDKSRSLNESK---IEIERLQSLTENLTKEHLMLEEELRNLRLEYD 1732 Query: 402 NKLRSKSTVFKKKHQIIAELKAEFGLLQ-RTEEL------LKQRHENIQQQLQTMEEKKG 454 + R +S K+ I EL+++ + RT EL L++ EN++Q+++ + K+ Sbjct: 1733 DLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQ-KQA 1791 Query: 455 ISGYSYTQEELERVSALKSEVDEM--KGRTLDDMSEMVKKLYSLVSEKKSALASVIKELR 512 + + QE + + + E + + K + L+ +++L ++ KS L + + + Sbjct: 1792 LEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQ 1851 Query: 513 QLRQKYQELTQECDEKKSQY---DSCAAGLESNRSKLEQEVRRLREEC--LQEESRYHYT 567 +L + Q++ + ++ K+QY + +ES R K E+E LR E LQ E + Sbjct: 1852 RLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEE 1911 Query: 568 NCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQ 611 C + LE R +++ S Q+E K + Y + Q Sbjct: 1912 RCR-RKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1954 Score = 66.2 bits (160), Expect = 9e-11 Identities = 110/566 (19%), Positives = 232/566 (40%), Gaps = 66/566 (11%) Query: 150 AFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIA 209 A + L K Y Q+K E+ + I+ + E + +R + ++ R + +N L+ A Sbjct: 1093 AKQNLDKCYGQIK-------ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA 1145 Query: 210 RQLRVE-----KEREEYLAQQKQEQKNQLFHAVQ----RLQRVQNQLKSMRQAAADAKPE 260 RQ E K E ++K+ + +L +Q R + +N+L +R + + Sbjct: 1146 RQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNE-EMS 1204 Query: 261 SLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEIN 320 +L + E EI + E ++ ++ K + L ++ E +++ L I + Sbjct: 1205 NLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQA- 1263 Query: 321 TEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKR 380 TE + E+ ++ + ++ +Q I K+ + ++ SLE A + Sbjct: 1264 TEQRRRAEENALQQKACGSEIMQKKQHLEI--ELKQVMQQRSEDNARHKQSLEEAAKTIQ 1321 Query: 381 NQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHE 440 ++ +E + + +E KR S V + I LK +F E + Sbjct: 1322 DKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQF------ETEINITKT 1375 Query: 441 NIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEK 500 I Q TM++++ SGY + L R + SE + TL +E ++++ + ++ Sbjct: 1376 TIHQL--TMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQ 1433 Query: 501 KSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLRE----- 555 K+ + V + +QL + +++TQ E+ +Y +E+ RL++ Sbjct: 1434 KATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKE 1493 Query: 556 ----ECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYIS--SDQQEKRKAIREQYTKNTA 609 +CL++E N ++ ++ L++A I+ Q+++ +R Y + + Sbjct: 1494 TNDRKCLEDE------NARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQ 1547 Query: 610 E-----------QENLGKKLREKQKVIRE-------SHGPNMKQAKMWRDLEQLMECKKQ 651 E Q +L + +KQKV E + + K+ K+ +LE + K+ Sbjct: 1548 ERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKE 1607 Query: 652 CFLK---QQSQTSIGQVIQEGGEDRL 674 +K Q ++++ ED L Sbjct: 1608 QAIKITNLTQQLEQASIVKKRSEDDL 1633 Score = 59.3 bits (142), Expect = 1e-08 Identities = 77/379 (20%), Positives = 162/379 (42%), Gaps = 47/379 (12%) Query: 112 LKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEI 171 LK++A L + + ++ + D +Q + L + + E+L+ + Sbjct: 1605 LKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEAL 1664 Query: 172 RKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKN 231 R+ + +E Q R EH +K +E + + ++E ER + L + ++ Sbjct: 1665 RRQLLQEQESVKQAHLRNEHFQKAIEDKS------RSLNESKIEIERLQSLTENLTKEHL 1718 Query: 232 QLFHAVQRLQRVQNQLKSMRQAAADAKPESLMK-RLEEEIKFN----LYMVTEKFPKELE 286 L ++ L+ + L+ R A K ++++ R + +I N L + +E E Sbjct: 1719 MLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERE 1778 Query: 287 NKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQ 346 N ++E+ QK LE ++I E + Q+++++ E + K+ + Q Sbjct: 1779 NLRQEIEKFQK----------QALEASNRIQESKNQCTQVVQER----ESLLVKIKVLEQ 1824 Query: 347 QASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRS 406 + + R + +EL AK ++LE E VK+ E ++ N L Sbjct: 1825 DKARLQRLE----DELNRAK---STLEAETRVKQRLE-----------CEKQQIQNDLNQ 1866 Query: 407 KSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEE---KKGISGYSYTQE 463 T + +K + I ++++E +R + L+ E +Q +++ +EE +K TQ Sbjct: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926 Query: 464 ELE-RVSALKSEVDEMKGR 481 +LE S + E+D+++ R Sbjct: 1927 QLETERSRYQREIDKLRQR 1945 Score = 33.1 bits (74), Expect = 0.86 Identities = 54/276 (19%), Positives = 114/276 (41%), Gaps = 30/276 (10%) Query: 418 IAELKAEFGLLQRTEELLKQRHENIQ--QQLQTMEEKKGISGYSYTQEELERVSALKSEV 475 + E A + L + E LLK E + +QLQ + + T E+ ++ + E Sbjct: 242 LREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQA--------TSREIMWINDCEEE- 292 Query: 476 DEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSC 535 E+ D + + +K + S + S L KEL +L+Q+ +L + ++ Sbjct: 293 -ELLYDWSDKNTNIAQKQEAF-SIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAY 350 Query: 536 AAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQE 595 L++ S + Q + + + L+E + Y ++ E L+ D ++ D+ Sbjct: 351 MDTLQTQWSWILQ-ITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNM 409 Query: 596 KRKAIREQYTKNTAEQENLGKKLREKQKVIRES--------HGPNMKQAKM--------W 639 + + EQ + E+E + + R+ Q ++ +S P+ + K + Sbjct: 410 PLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDY 469 Query: 640 RDLEQLMECKKQCFLKQQSQTSIGQVIQEGGEDRLI 675 + ++++ +C LK ++ S V GG D L+ Sbjct: 470 KQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLV 505 >gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo sapiens] Length = 1941 Score = 81.3 bits (199), Expect = 3e-15 Identities = 110/537 (20%), Positives = 228/537 (42%), Gaps = 71/537 (13%) Query: 168 TAEIRKDISAMEEE----KDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLA 223 +AE K+++ M+EE KD+L K KR E + +LK L+++ + E Sbjct: 848 SAETEKEMATMKEEFQKIKDELAKSEA---KRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904 Query: 224 QQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK 283 +E+ +QL +L+ ++K + + A D EEEI L K Sbjct: 905 ADAEERCDQLIKTKIQLEA---KIKEVTERAED----------EEEINAELTAKKRKLED 951 Query: 284 ELENKKKELHFLQ----KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEG 339 E KK++ L+ KV E + + L ++ ++ I +L ++K E + Sbjct: 952 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011 Query: 340 KLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVK---RNQTREFDGTEVLKGDE 396 L + + ++ +AK + Q+ + SLE+E ++ R+ +G L + Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071 Query: 397 FKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGIS 456 N+ + KKK I+ L+++ Q L+++ + +Q +++ +EE Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE----- 1126 Query: 457 GYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQ 516 + E ER S K+E + D+S ++++ + E A ++ I+ ++ Sbjct: 1127 -----EIEAERASRAKAE------KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1175 Query: 517 KYQELTQECDEKKSQYDSCAA------------------GLESNRSKLEQEVRRLREECL 558 ++Q++ ++ +E Q+++ AA L+ + KLE+E ++ E Sbjct: 1176 EFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235 Query: 559 QEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKR--KAIREQYTKNTAEQENLGK 616 S + NLE R D++ S +++++R + Q + E + Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295 Query: 617 KLREKQKVIRE-SHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGED 672 +L EK+ ++ + S G KQA +Q+ E K+Q + +++ ++ +Q D Sbjct: 1296 QLDEKEALVSQLSRG---KQA----FTQQIEELKRQLEEEIKAKNALAHALQSSRHD 1345 Score = 77.0 bits (188), Expect = 5e-14 Identities = 137/559 (24%), Positives = 243/559 (43%), Gaps = 60/559 (10%) Query: 111 ELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYE----QLKISGF 166 E K R L R KLE + Q E++ D + ++L E K KE+E Q KI Sbjct: 1047 EKKLRMDLERAKRKLEGDLKLAQ-ESIMDIENEKQQLDEKLKK--KEFEISNLQSKIEDE 1103 Query: 167 STA--EIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYL-- 222 +++K I ++ ++L + +E +R A+ + ++R+L ER E Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIE--AERASRAKAEKQRSDLSRELEEISERLEEAGG 1161 Query: 223 AQQKQEQKNQLFHA-VQRLQRVQNQLKSMRQAAADA---KPESLMKRLEEEIKFNLYMVT 278 A Q + N+ A Q+++R + +A A K + L E+I NL V Sbjct: 1162 ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQID-NLQRVK 1220 Query: 279 EKFPKELENKKKELHFLQKVVS--EPAMGHSD---------LLELESKINEINTEINQLI 327 +K KE K E+ L V A G+ + L EL+SK E IN L Sbjct: 1221 QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280 Query: 328 EKK-MMRNEPIEGKLSLYRQQASI--ISRKKEAKAEELQEAKEKLASLEREASVKRNQTR 384 ++ ++ E E L ++A + +SR K+A ++++E K +L E E K Sbjct: 1281 AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL---EEEIKAKNALAH 1337 Query: 385 EFDGT----EVLKGDEFKRYVNKLRSKSTVFKKKHQIIA-ELKAEFGLLQRTEELLKQRH 439 + ++L+ + +K + + K ++ K E +QRTEEL ++ Sbjct: 1338 ALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEEL-EEAK 1396 Query: 440 ENIQQQLQTMEEKKGISGYSYTQEELERVSA-LKSEVDEMK---GRTLDDMSEMVKKLYS 495 + + Q+LQ EE + + LE+ L++EV+++ RT + + KK + Sbjct: 1397 KKLAQRLQAAEEH--VEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRN 1454 Query: 496 ---LVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLES---NRSKLEQE 549 +++E K EL +++ + L E + K+ Y+ LE+ L+QE Sbjct: 1455 FDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQE 1514 Query: 550 VRRLREECLQEESRYHYTNCMIKNLE---VQLRRATDEMKAYISSDQQEKRKAIREQYTK 606 + L E+ + R H + K +E +L+ A +E +A S + E+ K +R Q Sbjct: 1515 ISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA---SLEHEEGKILRIQLEL 1571 Query: 607 NTAEQENLGKKLREKQKVI 625 N + E + +K+ EK + I Sbjct: 1572 NQVKSE-VDRKIAEKDEEI 1589 Score = 57.8 bits (138), Expect = 3e-08 Identities = 94/468 (20%), Positives = 195/468 (41%), Gaps = 62/468 (13%) Query: 144 YEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQ 203 YEE ++ +TL +E + L+ ++IS + E+ + KR+ L+K + + + Sbjct: 1494 YEESLDQLETLKRENKNLQ----------QEISDLTEQIAEGGKRIHELEKIKKQVEQEK 1543 Query: 204 WMLKIA-RQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESL 262 L+ A + E EE + Q + NQ+ V R +++ + ES+ Sbjct: 1544 CELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESM 1603 Query: 263 MKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTE 322 L+ EI+ + K K++E E+ E + H++ + E+ N NT+ Sbjct: 1604 QSTLDAEIRSRNDAIRLK--KKMEGDLNEM--------EIQLNHANRMAAEALRNYRNTQ 1653 Query: 323 INQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQ 382 L + ++ ++ + + L ++Q +++ R+ E++E + L ER Sbjct: 1654 -GILKDTQIHLDDALRSQEDL-KEQLAMVERRANLLQAEIEELRATLEQTER-------- 1703 Query: 383 TREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQI-IAELKAEF-GLLQRTEELLKQRHE 440 +R+ E+L E + ++ + KKK + I++++ E +LQ ++ + Sbjct: 1704 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKK 1763 Query: 441 NIQQQLQTMEEKKGISGYSYTQEELER-----VSALKSEVDEMKGRTLDDMSEMVKKLYS 495 I EE K S E +++ V L+ +DE + L + ++KL + Sbjct: 1764 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA 1823 Query: 496 LVSEKKSAL-------ASVIKELRQLRQKYQELTQECDEKKSQY-------DSCAAGLES 541 V E + + A +K LR+ ++ +ELT + +E + D A ++S Sbjct: 1824 RVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKS 1883 Query: 542 NRSKLEQ----------EVRRLREECLQEESRYHYTNCMIKNLEVQLR 579 + + E+ + R+L+ E + E R + L V+ R Sbjct: 1884 YKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSR 1931 Score = 46.6 bits (109), Expect = 8e-05 Identities = 69/312 (22%), Positives = 146/312 (46%), Gaps = 33/312 (10%) Query: 368 KLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKS-TVFKKKHQIIAELKAEFG 426 K A E+E + + + ++ + L E KR +L K T+ K+K+ + +++AE Sbjct: 847 KSAETEKEMATMKEEFQKIK--DELAKSEAKR--KELEEKMVTLLKEKNDLQLQVQAEAE 902 Query: 427 LL----QRTEELLK---QRHENIQQQLQTMEEKKGISG-YSYTQEELE-RVSALKSEVDE 477 L +R ++L+K Q I++ + E+++ I+ + + +LE S LK ++D+ Sbjct: 903 GLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 962 Query: 478 MKGRTLDDMSE-------MVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKS 530 ++ TL + + VK L ++ +A + KE + L++ +Q+ + ++ Sbjct: 963 LE-LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1021 Query: 531 QYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYIS 590 + ++ L + KLEQ+V L QE+ + LE L+ A + + Sbjct: 1022 KVNT----LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESI----- 1072 Query: 591 SDQQEKRKAIREQYTKNTAEQENLGKKLREKQKV-IRESHGPNMKQAKMWRDLEQLMECK 649 D + +++ + E+ K E NL K+ ++Q + I+ QA++ +LE+ +E + Sbjct: 1073 MDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI-EELEEEIEAE 1131 Query: 650 KQCFLKQQSQTS 661 + K + Q S Sbjct: 1132 RASRAKAEKQRS 1143 Score = 38.1 bits (87), Expect = 0.027 Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 5/111 (4%) Query: 124 KLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKD 183 KLE L+ E ++ + EA K L K ++K + T E RK+I +++ D Sbjct: 1820 KLEARVRELEGEVESEQKRN----AEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVD 1875 Query: 184 QLIKRVEHLKKRVETAQNH-QWMLKIARQLRVEKEREEYLAQQKQEQKNQL 233 +L +V+ K++ E A+ L R+L+ E E E A + Q N+L Sbjct: 1876 KLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926 Score = 37.7 bits (86), Expect = 0.035 Identities = 46/244 (18%), Positives = 106/244 (43%), Gaps = 24/244 (9%) Query: 145 EELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQW 204 +EL++A + + + Q + ++ DIS M+ E + +++ + +++ + A Sbjct: 1710 QELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAA 1769 Query: 205 MLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQN-QLKSMRQAAA--DAKPES 261 M+ A +L+ E++ +L + K+ + + RL + LK ++ +A+ Sbjct: 1770 MM--AEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRE 1827 Query: 262 LMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINT 321 L +E E K N V K ++ E + KEL + + ++L L+ ++++ Sbjct: 1828 LEGEVESEQKRNAEAV--KGLRKHERRVKELTY------QTEEDRKNILRLQDLVDKLQA 1879 Query: 322 EINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRN 381 ++ + E L+ +R+ EL+EA+E+ E + + R Sbjct: 1880 KVKSYKRQAEEAEEQSNTNLAKFRKLQ-----------HELEEAEERADIAESQVNKLRV 1928 Query: 382 QTRE 385 ++RE Sbjct: 1929 KSRE 1932 >gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo sapiens] Length = 1941 Score = 81.3 bits (199), Expect = 3e-15 Identities = 110/537 (20%), Positives = 228/537 (42%), Gaps = 71/537 (13%) Query: 168 TAEIRKDISAMEEE----KDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLA 223 +AE K+++ M+EE KD+L K KR E + +LK L+++ + E Sbjct: 848 SAETEKEMATMKEEFQKIKDELAKSEA---KRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904 Query: 224 QQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK 283 +E+ +QL +L+ ++K + + A D EEEI L K Sbjct: 905 ADAEERCDQLIKTKIQLEA---KIKEVTERAED----------EEEINAELTAKKRKLED 951 Query: 284 ELENKKKELHFLQ----KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEG 339 E KK++ L+ KV E + + L ++ ++ I +L ++K E + Sbjct: 952 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011 Query: 340 KLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVK---RNQTREFDGTEVLKGDE 396 L + + ++ +AK + Q+ + SLE+E ++ R+ +G L + Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071 Query: 397 FKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGIS 456 N+ + KKK I+ L+++ Q L+++ + +Q +++ +EE Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE----- 1126 Query: 457 GYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQ 516 + E ER S K+E + D+S ++++ + E A ++ I+ ++ Sbjct: 1127 -----EIEAERASRAKAE------KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1175 Query: 517 KYQELTQECDEKKSQYDSCAA------------------GLESNRSKLEQEVRRLREECL 558 ++Q++ ++ +E Q+++ AA L+ + KLE+E ++ E Sbjct: 1176 EFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235 Query: 559 QEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKR--KAIREQYTKNTAEQENLGK 616 S + NLE R D++ S +++++R + Q + E + Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295 Query: 617 KLREKQKVIRE-SHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGED 672 +L EK+ ++ + S G KQA +Q+ E K+Q + +++ ++ +Q D Sbjct: 1296 QLDEKEALVSQLSRG---KQA----FTQQIEELKRQLEEEIKAKNALAHALQSSRHD 1345 Score = 77.0 bits (188), Expect = 5e-14 Identities = 137/559 (24%), Positives = 243/559 (43%), Gaps = 60/559 (10%) Query: 111 ELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYE----QLKISGF 166 E K R L R KLE + Q E++ D + ++L E K KE+E Q KI Sbjct: 1047 EKKLRMDLERAKRKLEGDLKLAQ-ESIMDIENEKQQLDEKLKK--KEFEISNLQSKIEDE 1103 Query: 167 STA--EIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYL-- 222 +++K I ++ ++L + +E +R A+ + ++R+L ER E Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIE--AERASRAKAEKQRSDLSRELEEISERLEEAGG 1161 Query: 223 AQQKQEQKNQLFHA-VQRLQRVQNQLKSMRQAAADA---KPESLMKRLEEEIKFNLYMVT 278 A Q + N+ A Q+++R + +A A K + L E+I NL V Sbjct: 1162 ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQID-NLQRVK 1220 Query: 279 EKFPKELENKKKELHFLQKVVS--EPAMGHSD---------LLELESKINEINTEINQLI 327 +K KE K E+ L V A G+ + L EL+SK E IN L Sbjct: 1221 QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280 Query: 328 EKK-MMRNEPIEGKLSLYRQQASI--ISRKKEAKAEELQEAKEKLASLEREASVKRNQTR 384 ++ ++ E E L ++A + +SR K+A ++++E K +L E E K Sbjct: 1281 AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL---EEEIKAKNALAH 1337 Query: 385 EFDGT----EVLKGDEFKRYVNKLRSKSTVFKKKHQIIA-ELKAEFGLLQRTEELLKQRH 439 + ++L+ + +K + + K ++ K E +QRTEEL ++ Sbjct: 1338 ALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEEL-EEAK 1396 Query: 440 ENIQQQLQTMEEKKGISGYSYTQEELERVSA-LKSEVDEMK---GRTLDDMSEMVKKLYS 495 + + Q+LQ EE + + LE+ L++EV+++ RT + + KK + Sbjct: 1397 KKLAQRLQAAEEH--VEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRN 1454 Query: 496 ---LVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLES---NRSKLEQE 549 +++E K EL +++ + L E + K+ Y+ LE+ L+QE Sbjct: 1455 FDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQE 1514 Query: 550 VRRLREECLQEESRYHYTNCMIKNLE---VQLRRATDEMKAYISSDQQEKRKAIREQYTK 606 + L E+ + R H + K +E +L+ A +E +A S + E+ K +R Q Sbjct: 1515 ISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA---SLEHEEGKILRIQLEL 1571 Query: 607 NTAEQENLGKKLREKQKVI 625 N + E + +K+ EK + I Sbjct: 1572 NQVKSE-VDRKIAEKDEEI 1589 Score = 57.8 bits (138), Expect = 3e-08 Identities = 94/468 (20%), Positives = 195/468 (41%), Gaps = 62/468 (13%) Query: 144 YEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQ 203 YEE ++ +TL +E + L+ ++IS + E+ + KR+ L+K + + + Sbjct: 1494 YEESLDQLETLKRENKNLQ----------QEISDLTEQIAEGGKRIHELEKIKKQVEQEK 1543 Query: 204 WMLKIA-RQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESL 262 L+ A + E EE + Q + NQ+ V R +++ + ES+ Sbjct: 1544 CELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESM 1603 Query: 263 MKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTE 322 L+ EI+ + K K++E E+ E + H++ + E+ N NT+ Sbjct: 1604 QSTLDAEIRSRNDAIRLK--KKMEGDLNEM--------EIQLNHANRMAAEALRNYRNTQ 1653 Query: 323 INQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQ 382 L + ++ ++ + + L ++Q +++ R+ E++E + L ER Sbjct: 1654 -GILKDTQIHLDDALRSQEDL-KEQLAMVERRANLLQAEIEELRATLEQTER-------- 1703 Query: 383 TREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQI-IAELKAEF-GLLQRTEELLKQRHE 440 +R+ E+L E + ++ + KKK + I++++ E +LQ ++ + Sbjct: 1704 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKK 1763 Query: 441 NIQQQLQTMEEKKGISGYSYTQEELER-----VSALKSEVDEMKGRTLDDMSEMVKKLYS 495 I EE K S E +++ V L+ +DE + L + ++KL + Sbjct: 1764 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA 1823 Query: 496 LVSEKKSAL-------ASVIKELRQLRQKYQELTQECDEKKSQY-------DSCAAGLES 541 V E + + A +K LR+ ++ +ELT + +E + D A ++S Sbjct: 1824 RVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKS 1883 Query: 542 NRSKLEQ----------EVRRLREECLQEESRYHYTNCMIKNLEVQLR 579 + + E+ + R+L+ E + E R + L V+ R Sbjct: 1884 YKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSR 1931 Score = 46.6 bits (109), Expect = 8e-05 Identities = 69/312 (22%), Positives = 146/312 (46%), Gaps = 33/312 (10%) Query: 368 KLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKS-TVFKKKHQIIAELKAEFG 426 K A E+E + + + ++ + L E KR +L K T+ K+K+ + +++AE Sbjct: 847 KSAETEKEMATMKEEFQKIK--DELAKSEAKR--KELEEKMVTLLKEKNDLQLQVQAEAE 902 Query: 427 LL----QRTEELLK---QRHENIQQQLQTMEEKKGISG-YSYTQEELE-RVSALKSEVDE 477 L +R ++L+K Q I++ + E+++ I+ + + +LE S LK ++D+ Sbjct: 903 GLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 962 Query: 478 MKGRTLDDMSE-------MVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKS 530 ++ TL + + VK L ++ +A + KE + L++ +Q+ + ++ Sbjct: 963 LE-LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1021 Query: 531 QYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYIS 590 + ++ L + KLEQ+V L QE+ + LE L+ A + + Sbjct: 1022 KVNT----LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESI----- 1072 Query: 591 SDQQEKRKAIREQYTKNTAEQENLGKKLREKQKV-IRESHGPNMKQAKMWRDLEQLMECK 649 D + +++ + E+ K E NL K+ ++Q + I+ QA++ +LE+ +E + Sbjct: 1073 MDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI-EELEEEIEAE 1131 Query: 650 KQCFLKQQSQTS 661 + K + Q S Sbjct: 1132 RASRAKAEKQRS 1143 Score = 38.1 bits (87), Expect = 0.027 Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 5/111 (4%) Query: 124 KLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKD 183 KLE L+ E ++ + EA K L K ++K + T E RK+I +++ D Sbjct: 1820 KLEARVRELEGEVESEQKRN----AEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVD 1875 Query: 184 QLIKRVEHLKKRVETAQNH-QWMLKIARQLRVEKEREEYLAQQKQEQKNQL 233 +L +V+ K++ E A+ L R+L+ E E E A + Q N+L Sbjct: 1876 KLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926 Score = 37.7 bits (86), Expect = 0.035 Identities = 46/244 (18%), Positives = 106/244 (43%), Gaps = 24/244 (9%) Query: 145 EELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQW 204 +EL++A + + + Q + ++ DIS M+ E + +++ + +++ + A Sbjct: 1710 QELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAA 1769 Query: 205 MLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQN-QLKSMRQAAA--DAKPES 261 M+ A +L+ E++ +L + K+ + + RL + LK ++ +A+ Sbjct: 1770 MM--AEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRE 1827 Query: 262 LMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINT 321 L +E E K N V K ++ E + KEL + + ++L L+ ++++ Sbjct: 1828 LEGEVESEQKRNAEAV--KGLRKHERRVKELTY------QTEEDRKNILRLQDLVDKLQA 1879 Query: 322 EINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRN 381 ++ + E L+ +R+ EL+EA+E+ E + + R Sbjct: 1880 KVKSYKRQAEEAEEQSNTNLAKFRKLQ-----------HELEEAEERADIAESQVNKLRV 1928 Query: 382 QTRE 385 ++RE Sbjct: 1929 KSRE 1932 >gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 750 Score = 80.9 bits (198), Expect = 4e-15 Identities = 100/525 (19%), Positives = 237/525 (45%), Gaps = 62/525 (11%) Query: 169 AEIRKDISAMEEEKDQLIKRVEHLKKRVETAQ------------NH--QWMLKIARQLRV 214 A++++ + +E EK ++ V+ LK+++E A+ +H + + ++ +L+ Sbjct: 224 AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA 283 Query: 215 EKEREEYLAQQKQEQKNQLFHAVQRLQ----RVQNQLKSMRQAAADAKPESLMKRLEEEI 270 + E E + Q+Q+ +++ +++Q ++Q Q + +R+ + + R +EE+ Sbjct: 284 QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM 343 Query: 271 KFNLYMVTEKFPKELENKKKELHFLQKVV--SEPAMGHSD--LLELESKINEINTEINQL 326 + + + + K++++ ++++ E M + + E E KI E+ Sbjct: 344 MWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL------- 396 Query: 327 IEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREF 386 E+KM E I R++E K +E ++ +E+ E+EA + R + + Sbjct: 397 -EEKMHEQEKI---------------REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 440 Query: 387 DGTEVLKGDEFK--RYVNKLRSKSTVFKK-KHQIIAELKAEFGLLQRTEELLKQRHENIQ 443 + E ++ E K R K+ + + ++ K Q E+ + + EE+ +Q+ + + Sbjct: 441 EQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHE 500 Query: 444 QQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMK----GRTLDDMSEMVKKLYSLVSE 499 Q+ + ++++ + + QEE R K E K + + EM ++ + + Sbjct: 501 QEEKIRKQEEKV----WRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQ 556 Query: 500 KKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQ 559 +K +E + +E +E +EK + + E R + E+++ + E+ + Sbjct: 557 EKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIRE 616 Query: 560 EESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGK--- 616 +E + I+ E ++R +EM E+ + + EQ K ++E + + Sbjct: 617 QEEKIQEQEEKIREQEEKIREQ-EEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEE 675 Query: 617 KLREKQKVIRESHGPNMKQAKMWRDLEQLM--ECKKQCFLKQQSQ 659 K+RE++K IRE +Q +M ++ E+ M + +K C +++ Q Sbjct: 676 KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ 720 Score = 78.6 bits (192), Expect = 2e-14 Identities = 95/466 (20%), Positives = 217/466 (46%), Gaps = 48/466 (10%) Query: 197 ETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLF---HAVQRLQRVQNQLKSMRQA 253 E +HQ + R+L + L QK E + L+ HAV++L+ L S Sbjct: 110 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 169 Query: 254 A---ADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLL 310 + A ++L ++ K + Y+ E+ KE + EL+ + +++ + + Sbjct: 170 SWKFAGELEQALSAVATQKKKADRYI--EELTKERDALSLELY--RNTITDEELKEKN-A 224 Query: 311 ELESKINEINTEINQL-IEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKL 369 +L+ K+ + +E +++ + K ++ + KL L +QQ + + + +ELQ KL Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQ---LQAEADHLGKELQSVSAKL 281 Query: 370 ASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQ 429 + E + ++ + + ++ + + K++ + +++ + I E + + ++ Sbjct: 282 QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK---MR 338 Query: 430 RTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEM 489 R EE++ ++ E +++Q + M EK +E++ R + E +E R + M E Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEK---------EEKMRRQEEMMWEKEEKMRRQEEMMWEK 389 Query: 490 VKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQE 549 +K+ L E+K I+E + RQ+ +++ ++ EK+ + ++ E + E++ Sbjct: 390 EEKIREL--EEKMHEQEKIREQEEKRQEEEKIREQ--EKRQEQEAKMWRQEEKIREQEEK 445 Query: 550 VRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEM-----KAYISSDQQEKRKAIREQY 604 +R ++ ++E + H K E + R+ +EM K + + +++ + EQ Sbjct: 446 IREQEKKMWRQEEKIHEQE---KIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQE 502 Query: 605 TKNTAEQENLGK---KLREKQKVIRESHGPNMKQAKMWRDLEQLME 647 K ++E + + K+RE+++ IRE ++ KMWR E++ E Sbjct: 503 EKIRKQEEKVWRQEEKIREQEEKIRE------QEEKMWRQEEKIRE 542 Score = 75.1 bits (183), Expect = 2e-13 Identities = 112/551 (20%), Positives = 242/551 (43%), Gaps = 62/551 (11%) Query: 111 ELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAE 170 ELK++ A+ L+ P + LQ A+ + +EL L + E+ E Sbjct: 246 ELKRKLERAKLLL----PQQQLQ----AEADHLGKELQSVSAKLQAQVEE--------NE 289 Query: 171 IRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQK 230 + ++ +EEK + ++ E Q +W KI Q +E+EE + +Q+++ + Sbjct: 290 LWNRLNQQQEEK---------MWRQEEKIQ--EWEEKIQEQEEKIREQEEKIREQEEKMR 338 Query: 231 NQLFHAVQRLQRVQNQLKSMRQAAADAK-PESLMKRLEEEIKFNLYMVTEKFPK--ELEN 287 Q ++ ++++ Q + M + + E +M EE+++ M+ EK K ELE Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 398 Query: 288 KKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPI-EGKLSLYRQ 346 K E +++ E + + + K E ++ + EK + E I E + ++RQ Sbjct: 399 KMHEQEKIRE--QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ 456 Query: 347 QASIISRKKEAKAEELQEAKEKLASLER---EASVKRNQTREFDGTEVLKGDEFK--RYV 401 + I ++K + E+ QE +E E+ + + R + + + E ++ E K R Sbjct: 457 EEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQE 516 Query: 402 NKLRSKSTVFKKKHQII---AELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGY 458 K+R + +++ + + E E + R EE + ++ + +++ + +E K Sbjct: 517 EKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQE 576 Query: 459 SYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSL--VSEKKSALASVIKELRQLRQ 516 +E+ E+V + ++ E + + + +M K+ + EK I+E + + Sbjct: 577 EKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIR 636 Query: 517 KYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEV 576 + +E+TQE +EK + + E + E+ + R E+ ++E + I+ E Sbjct: 637 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKK-------IREQEE 689 Query: 577 QLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQA 636 ++R + M QE+ + + EQ K ++E K++E+++ +R +Q Sbjct: 690 KIREQEEMM--------QEQEEKMWEQEEKMCEQEE----KMQEQEEKMRRQEEKMWEQE 737 Query: 637 KMWRDLEQLME 647 R E+ M+ Sbjct: 738 VRLRQQEEKMQ 748 Score = 73.6 bits (179), Expect = 6e-13 Identities = 101/534 (18%), Positives = 245/534 (45%), Gaps = 45/534 (8%) Query: 149 EAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI 208 EA + + ++ K +G E+ + +SA+ +K + + +E L K + L++ Sbjct: 159 EARDLISRLHDSWKFAG----ELEQALSAVATQKKKADRYIEELTKERDALS-----LEL 209 Query: 209 ARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAK---PESLMKR 265 R ++E +E A K ++K QL + + +Q +K +++ AK P+ ++ Sbjct: 210 YRNTITDEELKEKNA--KLQEKLQLVESEK--SEIQLNVKELKRKLERAKLLLPQQQLQA 265 Query: 266 LEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQ 325 + + L V+ K ++E + Q+ + + E E KI E +I + Sbjct: 266 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 325 Query: 326 LIEKKMMRNEPIEGKLSLYRQQASIISRKKEA---KAEELQEAKEKLASLEREASVKRNQ 382 EK + E + + + ++ + R++E K E+++ +E + E+E ++R + Sbjct: 326 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM--WEKEEKMRRQE 383 Query: 383 TREFDGTEVLKGDEFKRYVN-KLRSKSTVFKKKHQIIAELKAEF--GLLQRTEELLKQRH 439 ++ E ++ E K + K+R + +++ +I + K + + R EE ++++ Sbjct: 384 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 443 Query: 440 ENIQQQLQTM-EEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVS 498 E I++Q + M +++ I +EE +R + E K +++ +K++ Sbjct: 444 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEE 503 Query: 499 EKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECL 558 + + V ++ ++R++ +++ ++ ++ Q + E R E+E +E+ Sbjct: 504 KIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR---EEEKMHEQEKIW 560 Query: 559 QEESRYHYTNCM------IKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQE 612 +EE R + M I+ E ++ R ++++ +Q+EKR+ E+ K + Sbjct: 561 EEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIR-----EQEEKRQEQEEKMWKQEEKIR 615 Query: 613 NLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLM------ECKKQCFLKQQSQT 660 +K++E+++ IRE +Q +M ++ E+ M C+++ +++Q +T Sbjct: 616 EQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEET 669 Score = 65.1 bits (157), Expect = 2e-10 Identities = 102/436 (23%), Positives = 194/436 (44%), Gaps = 61/436 (13%) Query: 226 KQEQKNQLFHAVQRLQRVQNQLK-SMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKE 284 K+ ++++L A ++L Q S+ AA+D K + + E T Sbjct: 53 KETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPET------TTSGGCHS 106 Query: 285 LENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLY 344 E+++K H Q+ + ELE++++ I Q E +M L Sbjct: 107 PEDEQKASHQHQEALRR---------ELEAQVHTIRILTCQKTELQMALYYSQHAVKQLE 157 Query: 345 RQQASIISRKKEAK--AEELQEAKEKLASLEREASVKRNQ-TREFDGTEVLKGDEFKRYV 401 + +ISR ++ A EL++A +A+ +++A + T+E D + + ++ + Sbjct: 158 GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSL---ELYRNTI 214 Query: 402 N--KLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENI-----QQQLQTMEEKKG 454 +L+ K+ ++K Q++ K+E +Q + LK++ E QQQLQ + G Sbjct: 215 TDEELKEKNAKLQEKLQLVESEKSE---IQLNVKELKRKLERAKLLLPQQQLQAEADHLG 271 Query: 455 ISGYSYTQEELERVSA-LKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQ 513 +EL+ VSA L+++V+E +E+ +L EK I+E + Sbjct: 272 --------KELQSVSAKLQAQVEE---------NELWNRLNQQQEEKMWRQEEKIQEWEE 314 Query: 514 LRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKN 573 Q+ +E +E +EK + + E + E+++RR E ++E + M+ Sbjct: 315 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 374 Query: 574 LEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENL--GKKLREKQKVIRESHGP 631 E ++RR + M EK + IRE K EQE + ++ R++++ IRE Sbjct: 375 KEEKMRRQEEMM--------WEKEEKIRELEEK-MHEQEKIREQEEKRQEEEKIREQEKR 425 Query: 632 NMKQAKMWRDLEQLME 647 ++AKMWR E++ E Sbjct: 426 QEQEAKMWRQEEKIRE 441 Score = 44.7 bits (104), Expect = 3e-04 Identities = 67/330 (20%), Positives = 144/330 (43%), Gaps = 43/330 (13%) Query: 355 KEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNK-LRSKSTVFKK 413 KE + +L EAKE+L QT GT D K+ +N ++T Sbjct: 53 KETRQSKLAEAKEQLTD-------HHPQTNPSVGTAA--SDTKKKKINNGTNPETTTSGG 103 Query: 414 KHQIIAELKAEFGLLQRTEELLKQRHENIQQ-QLQTMEEKKGISGYSYTQEELERVSALK 472 H E KA Q E L ++ + ++ T ++ + Y+Q +++ L+ Sbjct: 104 CHSPEDEQKASH---QHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQ---LE 157 Query: 473 SEVDEMKGRTLDDMS---EMVKKLYSLVSEKKSA---LASVIKELRQLRQKYQELT---Q 523 E ++ R D E+ + L ++ ++KK A + + KE L + T + Sbjct: 158 GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE 217 Query: 524 ECDEKKSQYDSCAAGLESNRSKLEQEVRRLREEC---------LQEESRYHYTNCMIKNL 574 E EK ++ +ES +S+++ V+ L+ + Q ++ + ++++ Sbjct: 218 ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 277 Query: 575 EVQLRRATDEMKAYISSDQQEKRKAIREQ-----YTKNTAEQENLGKKLREKQKVIRESH 629 +L+ +E + + +QQ++ K R++ + + EQE +K+RE+++ IRE Sbjct: 278 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE---EKIREQEEKIREQE 334 Query: 630 GPNMKQAKMWRDLEQLMECKKQCFLKQQSQ 659 +Q +M + E+ M +++ +++ + Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 364 Score = 37.7 bits (86), Expect = 0.035 Identities = 42/225 (18%), Positives = 102/225 (45%), Gaps = 16/225 (7%) Query: 460 YTQEELERVSALKSEV--DEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQK 517 Y +E + AL E+ + + L + + +++ LV +KS + +KEL++ ++ Sbjct: 194 YIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLER 253 Query: 518 ------YQELTQECDEKKSQYDSCAAGLESN--RSKLEQEVRRLREECL-QEESRYHYTN 568 Q+L E D + S +A L++ ++L + + +EE + ++E + Sbjct: 254 AKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE 313 Query: 569 CMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRES 628 I+ E ++R ++++ +Q+EK + E + + + + EK++ +R Sbjct: 314 EKIQEQEEKIREQEEKIR-----EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 368 Query: 629 HGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVIQEGGEDR 673 ++ + R E++M K++ + + + + I+E E R Sbjct: 369 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKR 413 >gi|41872583 Rho-associated, coiled-coil containing protein kinase 2 [Homo sapiens] Length = 1388 Score = 80.9 bits (198), Expect = 4e-15 Identities = 102/498 (20%), Positives = 221/498 (44%), Gaps = 50/498 (10%) Query: 175 ISAMEEEKDQLIKRVEHLKKRVETAQ-NHQWMLKIARQLRVEKEREEYLAQQKQEQKNQL 233 ++ +E EK QL +R L+K + + + LK+ +Q ++E E + + KN++ Sbjct: 662 LAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKI 721 Query: 234 FHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELH 293 + +++ +A ++A E K LEE + +K L +K Sbjct: 722 YESIE-------------EAKSEAMKEMEKKLLEERT------LKQKVENLLLEAEKRCS 762 Query: 294 FLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISR 353 L + + ++LL+ + +NE + IE++ + + L + QQ + + Sbjct: 763 LLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKM 822 Query: 354 KKEAKAEELQEAKEKLASLEREASVKRNQTREFDG--TEVLKGDEFKRYVNKLRSKSTVF 411 ++ +E E +LE++ + R + ++ DG E+ E ++Y + L K+ V Sbjct: 823 SEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTL-YKTQVR 881 Query: 412 KKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEK-------KGISGYSYTQEE 464 + K + + K L Q+ +EL +R +++ QL+ K + I+ Y+ E Sbjct: 882 ELKEECEEKTKLGKELQQKKQELQDER-DSLAAQLEITLTKADSEQLARSIAEEQYSDLE 940 Query: 465 LERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKK---SALASVIKELRQLRQKYQEL 521 E++ + E+ EM R +++E + SL + S +A++ E +L K +++ Sbjct: 941 KEKIMK-ELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDV 999 Query: 522 TQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRA 581 ++ K + S AA K + E + L E L+ T + K E+ R+ Sbjct: 1000 QEQLSRLKDEEISAAA------IKAQFEKQLLTERTLK-------TQAVNKLAEIMNRK- 1045 Query: 582 TDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRD 641 + +K +D + K K R+ + + +E+E L +++ + QK + E +++++ + Sbjct: 1046 -EPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIE 1104 Query: 642 LEQLMECKKQCFLKQQSQ 659 L+ ++ K + +SQ Sbjct: 1105 LQMTLDSKDSDIEQLRSQ 1122 Score = 58.9 bits (141), Expect = 1e-08 Identities = 90/429 (20%), Positives = 186/429 (43%), Gaps = 61/429 (14%) Query: 137 VADTNKQYEELMEA--------------FKTLHKEYEQLKISGFSTAEI--------RKD 174 +AD NK YE + EA +TL ++ E L + + ++ Sbjct: 715 LADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQK 774 Query: 175 ISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLF 234 I+ + ++KD L + V +L ++E Q Q L+++ ++ L +++ K + Sbjct: 775 INELLKQKDVLNEDVRNLTLKIE--QETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENN 832 Query: 235 HAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVT--EKFPKELENKKKEL 292 H ++ ++ Q +R+ DA + MK L+++++ Y T + +EL+ + +E Sbjct: 833 HLMEMKMNLEKQNAELRKERQDA--DGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEK 890 Query: 293 HFLQKVVSEPAMGHSDLLELESKINEINTEINQL---IEKKMMRNEPIEGKLSLYRQQAS 349 L K EL+ K E+ E + L +E + + + + S+ +Q S Sbjct: 891 TKLGK-------------ELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYS 937 Query: 350 IISRKKEAKAEELQE--AKEKLASLEREASV----KRNQTREFDGTEVL-KGDEFKRYVN 402 + ++K K E++E A+ K E++A++ + N+T D + + +E + Sbjct: 938 DLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLK 997 Query: 403 KLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEE--KKGISGYSY 460 ++ + + K + A +KA+F TE LK + N ++ +E K+G Sbjct: 998 DVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVR 1057 Query: 461 TQEELERV--SALKSEVDEMK------GRTLDDMSEMVKKLYSLVSEKKSALASVIKELR 512 +E+ R LKSE +++ + L++M + + + E + L S ++ Sbjct: 1058 RKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIE 1117 Query: 513 QLRQKYQEL 521 QLR + Q L Sbjct: 1118 QLRSQLQAL 1126 Score = 39.7 bits (91), Expect = 0.009 Identities = 44/226 (19%), Positives = 99/226 (43%), Gaps = 36/226 (15%) Query: 457 GYSYTQEELERVSALKS-EVDEMKGRTLDDMSEMVKKLYSL---VSEKKSALASVIKELR 512 G++Y +E L + E D ++ R ++ E+ KKLY+L +S + A + ++ + Sbjct: 412 GFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCK 471 Query: 513 QLRQKYQELTQECDE------------------------KKSQYDSCAAGLESNRSKLEQ 548 + + ++ +E +E K ++Y A + LE Sbjct: 472 SVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLEN 531 Query: 549 EVRRLREECLQEESRYHYTNCMIKNLEV-QLRRATDEMKAYI--SSDQQEKRKAIREQYT 605 +V L+++ E+ + N I +V QL+R DE A + SD + + + + + Sbjct: 532 DVNSLKDQL--EDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESS 589 Query: 606 KNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQ 651 K + E+ + L++K ++ + +K K + +L+ +E +++ Sbjct: 590 KQIQQLESNNRDLQDKNCLLETA---KLKLEKEFINLQSALESERR 632 Score = 32.3 bits (72), Expect = 1.5 Identities = 81/430 (18%), Positives = 174/430 (40%), Gaps = 75/430 (17%) Query: 29 LEPMQLLQVLSDVLAEIDPK-QLVDIREEMPEQTAKRMLSLLGILKYKPSGNAT---DMS 84 LE L Q + ++L E + + L+D + +Q +L +L + N T + Sbjct: 741 LEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLN-EDVRNLTLKIEQE 799 Query: 85 TFRQGLVIGSKPVIYPVLHWLLQRTNELKKRA-YLARFLIKLEVPSEFLQDETVADTNKQ 143 T ++ L + ++ L +LK+ +L + LE + L+ E D + Q Sbjct: 800 TQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKER-QDADGQ 858 Query: 144 YEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQ 203 +EL + QL+ + + + + ++EE ++ K + L+++ + Q+ + Sbjct: 859 MKELQD----------QLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDER 908 Query: 204 WMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLM 263 L ++ + K E LA+ E++ +D + E +M Sbjct: 909 DSLAAQLEITLTKADSEQLARSIAEEQ-----------------------YSDLEKEKIM 945 Query: 264 KRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEI 323 K LE + + + +EL K + L++ SD+ L ++ E+N ++ Sbjct: 946 KELE------IKEMMARHKQELTEKDATIASLEETNRTLT---SDVANLANEKEELNNKL 996 Query: 324 NQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQT 383 +++++ R L ++ S + K + + + L E K ++ + A + + Sbjct: 997 KD-VQEQLSR---------LKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRK- 1045 Query: 384 REFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQ 443 V +G++ +R K +K H ELK+E L T++++K + E + Sbjct: 1046 -----EPVKRGND-----TDVRRKEKENRKLHM---ELKSEREKL--TQQMIKYQKELNE 1090 Query: 444 QQLQTMEEKK 453 Q Q EE + Sbjct: 1091 MQAQIAEESQ 1100 >gi|114155142 nuclear pore complex-associated protein TPR [Homo sapiens] Length = 2363 Score = 80.9 bits (198), Expect = 4e-15 Identities = 92/466 (19%), Positives = 206/466 (44%), Gaps = 64/466 (13%) Query: 136 TVADTNKQYEELMEAFKTLHKEYE----QLKISGFSTAEIRKDISAMEEE----KDQLIK 187 ++++ K E+++E + + +E E + +++ + R+ + +E E +D L Sbjct: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244 Query: 188 RVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQL 247 E ++ +T H+ ++K + V E + L ++K+ + L ++++++ + Sbjct: 1245 EREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDI 1304 Query: 248 KSMRQAAADAKPESLM-----KRLEEEIKF----NLYMV-------TEKFPKELENKKKE 291 +++A A+ +S M K LEE++K N ++V TE++ K L K+ Sbjct: 1305 LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVH 1364 Query: 292 LHFLQKVV-------SEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLY 344 +Q++ +E A ++ L ++ I + ++N++ +K + ++ K+ Sbjct: 1365 TKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDI 1424 Query: 345 RQ------QASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFK 398 ++ Q I R+ + + EEL+ ++K+ E S + + + V + E K Sbjct: 1425 QEKVKTITQVKKIGRRYKTQYEELKAQQDKVM----ETSAQSSGDHQEQHVSVQEMQELK 1480 Query: 399 RYVNKLRSKSTVFKKK----HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKG 454 +N+ +KS + + + ++E + E LQ L+ ++Q LQ Sbjct: 1481 ETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRT---- 1536 Query: 455 ISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQL 514 TQEE L+ ++ E + +T + K+ L K + KE +L Sbjct: 1537 ------TQEE-----QLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQ----LTKENEEL 1581 Query: 515 RQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQE 560 +Q+ L Q+ DE + + + E S+LE+E+R +E L++ Sbjct: 1582 KQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQ 1627 Score = 70.5 bits (171), Expect = 5e-12 Identities = 97/428 (22%), Positives = 188/428 (43%), Gaps = 49/428 (11%) Query: 197 ETAQNHQWMLKIARQLRVEKEREEY---LAQQKQEQKNQLFHAVQR-LQRVQNQLKSMRQ 252 E ++ + +L+I R +R EKE E +AQ + + Q ++R LQ +Q+ L + R+ Sbjct: 1188 EEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAERE 1247 Query: 253 -----AAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHS 307 A A+ E LMK+ E N+ M T K +E K++ LQ++ ++ Sbjct: 1248 KVQVTAKTMAQHEELMKKTET---MNVVMETNKMLRE--EKERLEQDLQQMQAKVRKLEL 1302 Query: 308 DLLELESKINEINTEINQL-IEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAK 366 D+L L+ E++ + L EKK++ + K + ++S++K+ EE + Sbjct: 1303 DILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKA----RNQHLVSQQKDPDTEEYR--- 1355 Query: 367 EKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFG 426 KL S E+E KR Q +E R ++ + +I LK + Sbjct: 1356 -KLLS-EKEVHTKRIQQLT---------EEIGRLKAEIARSNASLTNNQNLIQSLKEDLN 1404 Query: 427 LLQRTEELLKQRHE----NIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRT 482 ++ +E +++ + +IQ++++T+ + K I TQ E + A + +V E ++ Sbjct: 1405 KVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQ--YEELKAQQDKVMETSAQS 1462 Query: 483 LDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESN 542 D E + + E K L + + L + + L + EK+++ A L+ Sbjct: 1463 SGDHQEQHVSVQEM-QELKETLNQAETKSKSLESQVENLQKTLSEKETE----ARNLQEQ 1517 Query: 543 RSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIRE 602 +L+ E+ RLR++ ++ I E + R+A K+ I+ +++ Sbjct: 1518 TVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIA-----HLAGVKD 1572 Query: 603 QYTKNTAE 610 Q TK E Sbjct: 1573 QLTKENEE 1580 Score = 67.4 bits (163), Expect = 4e-11 Identities = 97/498 (19%), Positives = 208/498 (41%), Gaps = 33/498 (6%) Query: 142 KQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQN 201 KQ +E+ E +K E E KI ++++ ++ + + ++ +++ KR E Q+ Sbjct: 673 KQLQEIFENYKKEKAENE--KIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQD 730 Query: 202 HQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPES 261 + + R++ ER + L Q+Q+ + Q L+ +L A + K E Sbjct: 731 N--VEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEK 788 Query: 262 LMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLE-LESKINEIN 320 M +L E L E E + L LQ + ++ + L S+I ++ Sbjct: 789 EMLKLSE---VRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLE 845 Query: 321 TEINQLIEKKMMRNEPIEGKLSLYRQ-QASIISRKKEAKAEE---------LQEAKEKLA 370 EI+ L KK + NE +E + +L R ++ K++ E L+ A++++A Sbjct: 846 HEISHL--KKKLENE-VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIA 902 Query: 371 SLEREASVKRNQTREFDGTEVLKG-----DEFKRYVNKLRSKSTVFKKKHQIIAELKAEF 425 +L++ S Q KG ++ V++LR ++ + + LK Sbjct: 903 TLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTE---EQVNDLKERLKTST 959 Query: 426 GLLQRTEELLKQRHENIQQQLQTMEE-KKGISGYSYTQEELERVSALK-SEVDEMKGRTL 483 +++ + ++ E++ ++ Q EE +K I E + K EV++ K Sbjct: 960 SNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ 1019 Query: 484 DDMSEMVKKLYSLVSEKKSALASVIKELRQ-LRQKYQELTQECDEKKSQYDSCAAGLES- 541 DD ++ + +SE K L+SV E+++ L++ L+ E ++ + +E+ Sbjct: 1020 DDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQ 1079 Query: 542 NRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIR 601 N+ + E + E LQ ++ + + + + +E+ + ++ Sbjct: 1080 NKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLK 1139 Query: 602 EQYTKNTAEQENLGKKLR 619 ++ +K E+L K+ R Sbjct: 1140 DEVSKCVCRCEDLEKQNR 1157 Score = 51.6 bits (122), Expect = 2e-06 Identities = 100/465 (21%), Positives = 183/465 (39%), Gaps = 73/465 (15%) Query: 124 KLEVPSEFLQDETV---ADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180 +LE E L + + + +EL+ + E +LK + ++++S +EE Sbjct: 182 RLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCN---LENKKEEVSRLEE 238 Query: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240 + + L EHL+K VE L KE +E A +++ N+L Sbjct: 239 QMNGLKTSNEHLQKHVEDL------------LTKLKEAKEQQASMEEKFHNEL------- 279 Query: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300 +L ++ ++AAD + E K N EL +ELH L K Sbjct: 280 -NAHIKLSNLYKSAAD----------DSEAKSN----------ELTRAVEELHKLLKEAG 318 Query: 301 EPAMGHSD-LLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKA 359 E D LLE+E +++ E+ + I + E LS +++ +I+S ++ A Sbjct: 319 EANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAM 378 Query: 360 EELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIA 419 A K+ + + N E +L+ E KR L + K I+ Sbjct: 379 SPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILK 438 Query: 420 ELKAEFGLLQRTEELLKQRHENIQQQLQTMEE-----KKGISGYSYTQEELE-------- 466 + E+ Q+ L + E +++Q ++E K S +E Sbjct: 439 RQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQ 498 Query: 467 RVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQEL----- 521 ++ L E++E +G + E+ S SE S + + +L+Q+ Q L Sbjct: 499 QIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALR 558 Query: 522 ----TQECDEKK---SQYDSCAAGLESNRSKLEQEVRRLREECLQ 559 T+E +E++ S+ LES ++LEQ +R+ R+ +Q Sbjct: 559 ELGETREREEQETTSSKITELQLKLESALTELEQ-LRKSRQHQMQ 602 Score = 37.4 bits (85), Expect = 0.046 Identities = 75/349 (21%), Positives = 145/349 (41%), Gaps = 60/349 (17%) Query: 343 LYRQQASIISRKKEAKAEE-LQEAKEKLASLE-REASVKRNQTREFDGTEVLKGDEFKRY 400 L R + + + + + K E+ L + + ++ L+ R K +++ E +R Sbjct: 9 LERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERL 68 Query: 401 VNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSY 460 VN+ R ++ + ++ +LKA L ++ +EL + NI Q Q ++ Sbjct: 69 VNETRECQSLRLELEKLNNQLKA---LTEKNKELEIAQDRNIAIQSQ----------FTR 115 Query: 461 TQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQ---- 516 T+EELE +E + L+ ++E VK+L + E + + +L +L+ Sbjct: 116 TKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVS 175 Query: 517 -KYQE--LTQECD-----------EKKSQYDSCAA----------GLESNRSKLEQEVRR 552 KY+E L QE + E K++ D A L+ N ++EV R Sbjct: 176 VKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSR 235 Query: 553 LREE-----CLQEESRYHYTNCMIKNLEVQLRRAT------DEMKAYIS-----SDQQEK 596 L E+ E + H + + K E + ++A+ +E+ A+I + Sbjct: 236 LEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADD 295 Query: 597 RKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQL 645 +A + T+ E L K+ E K I++ H ++Q+K + E L Sbjct: 296 SEAKSNELTRAVEELHKLLKEAGEANKAIQD-HLLEVEQSKDQMEKEML 343 >gi|221219020 NYD-SP11 protein [Homo sapiens] Length = 2873 Score = 80.1 bits (196), Expect = 6e-15 Identities = 121/572 (21%), Positives = 264/572 (46%), Gaps = 66/572 (11%) Query: 126 EVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQL 185 E ++ Q+E + K E+L + + + +E E+L G ++ + + +++++ Sbjct: 1765 EEETKLAQEEELLIQEK--EKLAQHKEKMPEEEERL---GRKREQLIEKKMKLAQKRERW 1819 Query: 186 IKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQE---QKNQLFHAVQRLQR 242 I +E L K + + + + L EKE+ LAQ+K+ K +L H+ ++L + Sbjct: 1820 INSMEELTKNKMILYQKKNLAQEKKNLAQEKEK---LAQRKENLLYNKERLTHSKKQLVQ 1876 Query: 243 VQNQLKSMRQAAADA------KPESLMKRLEE--EIKFNLYMVTEKFPKELENKKKELHF 294 V+N+L + A + E+++K+ E+ E + L V + K+ E +E Sbjct: 1877 VKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQE--- 1933 Query: 295 LQKVVSEPAM--GHSDL---LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQAS 349 K+ E AM G L L++ + +N E+ +L E+KM +EGK +L + + Sbjct: 1934 KMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKM---RLVEGKETLSKGETP 1990 Query: 350 IISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGD-EFKR----YV--- 401 SR+++ E QE E+ SLE + + ++ + +E+ KG EF R +V Sbjct: 1991 ETSRQRKMTQVE-QELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQ 2049 Query: 402 NKLRSKSTVFKKKHQIIAELKAEFG-LLQRTEELLKQRHENIQQQLQTMEEKKGISGYSY 460 KL S KK + +++ A+ +L+ ++L + + Q++++ + K+ + + Sbjct: 2050 RKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRAL----F 2105 Query: 461 TQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQE 520 +E R+S +S++D + + SE+ K L +++ + ++R++ K ++ Sbjct: 2106 VKE--RRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQR----KLANKMRRMINKEEK 2159 Query: 521 LTQECDEKKSQYDSCAAGLESNRSKLEQEV-------RRLREECLQEESRYHYTNCMIKN 573 +T+E + ++ E E+EV R R+E + + + + Sbjct: 2160 MTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDE 2219 Query: 574 LE------VQLRRATDEMKAY--ISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVI 625 +E ++ DE++ +SS+++E+R+ E+ + E+E K+ E ++ Sbjct: 2220 VESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQ 2279 Query: 626 RESHGPNMKQAKMWRDLEQLMECKKQCFLKQQ 657 E K+ K + E++ E K++ F +++ Sbjct: 2280 VEKEEEEKKKKKKEKKKEEVQE-KEEVFEEKE 2310 Score = 66.2 bits (160), Expect = 9e-11 Identities = 118/568 (20%), Positives = 237/568 (41%), Gaps = 72/568 (12%) Query: 124 KLEVPSEFLQDETVADTNKQYEELMEAFKT-LHKEYEQLKISGFSTAEIRKDISAMEEEK 182 KL E LQ+ D ++EE + ++ L + ++ + + +++S EEK Sbjct: 1502 KLSPEEEMLQE----DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEK 1557 Query: 183 DQ-LIKRVEHLKKRVETAQNHQWMLKIARQLRVEKER---EEYLAQQKQ---EQKNQLFH 235 +Q + + H++ + H+W ++ R EK+R E LAQ+++ +++ QL Sbjct: 1558 EQQVTEEQRHIQ------EEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQ 1611 Query: 236 AVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFL 295 ++L Q +K + A+ E + EE L EK +E E ++ L Sbjct: 1612 EERKL--AQAYVKITQDDREMAQAEGKFAQKEE----TLAQRGEKLSQEAEKLAQKRKKL 1665 Query: 296 QKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKK 355 K + A L + K+ E+ + Q +E+ R + ++ ++ Sbjct: 1666 AKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDW--------------QE 1711 Query: 356 EAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKH 415 + A+EL+E + + E S K + + +G V +E K KL + + Sbjct: 1712 KELAQELEELEWDM----EELSWKEEELNQEEGKLV---EEKK----KLAEEEEALAWQR 1760 Query: 416 QIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEV 475 + ++E + + L + EELL Q E + Q + M E++ G + E++ K ++ Sbjct: 1761 EKLSEEETK---LAQEEELLIQEKEKLAQHKEKMPEEEERLG-----RKREQLIEKKMKL 1812 Query: 476 DEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSC 535 + + R ++ M E+ K ++ +K LA K L Q ++K + + K + Sbjct: 1813 AQKRERWINSMEELTKN--KMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHS 1870 Query: 536 AAGLESNRSKL---EQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSD 592 L ++KL + + ++ E+ QE+ + E +L + D + Sbjct: 1871 KKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKL 1930 Query: 593 QQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQC 652 QEK K E+ K+LR + + +E N++ ++ + +L+E K+ Sbjct: 1931 AQEKMKLALEKAMVQGK------KRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETL 1984 Query: 653 FLKQQSQTS----IGQVIQEGGEDRLIL 676 + +TS + QV QE E +L L Sbjct: 1985 SKGETPETSRQRKMTQVEQELFERKLSL 2012 Score = 54.7 bits (130), Expect = 3e-07 Identities = 75/353 (21%), Positives = 161/353 (45%), Gaps = 37/353 (10%) Query: 172 RKDISAMEEEKDQLIKRVEHLKK-RVETAQNHQWMLKIARQLRVEKEREEYLAQQK---- 226 R+ +S + ++++K ++ L + + Q M K+ R L V KER + Q K Sbjct: 2063 RESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFV-KERRLSIEQSKLDIK 2121 Query: 227 ----QEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFP 282 E++++L ++L R Q +L + + + + + + + K + ++ ++ Sbjct: 2122 EWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEE 2181 Query: 283 KELENKKKELHFLQK---VVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEG 339 +E +++ + FL++ E G + S+++E+ +E + +E +E Sbjct: 2182 GGIE-EEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHF--------SEEMES 2232 Query: 340 KLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKR 399 L +Q S+ S ++E + EE + +E++ RE +R + E + +V K +E K+ Sbjct: 2233 LLDELEKQESLSSEEEEEREEEEEREEEEV----REEEEERKEEEEGEEKQVEKEEEEKK 2288 Query: 400 YVNK------LRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKK 453 K ++ K VF++K +I++E + E + EE E + ++ + ++++K Sbjct: 2289 KKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEK 2348 Query: 454 GISGYSYTQEEL---ERVSALKSEVDEMKGRT--LDDMSEMVKKLYSLVSEKK 501 ++ L ERV ++ V KGR L + +KKL S E K Sbjct: 2349 QFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMK 2401 Score = 48.1 bits (113), Expect = 3e-05 Identities = 68/352 (19%), Positives = 149/352 (42%), Gaps = 40/352 (11%) Query: 322 EINQLIEKKMMRNEPIEGKLSLYRQQ-ASIISRKKEAKAEELQEAKEKLASLEREASVKR 380 EI++ EKK + P +G+ ++ +++ I R+ + ++ E E++A+LE + + Sbjct: 1386 EISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQE 1445 Query: 381 NQTREFDGTEVLKG-----DEFKRYVNKLRSKSTVFK------------KKHQIIAELKA 423 + + T + DE+K+ + R +K K HQ +L Sbjct: 1446 GKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSP 1505 Query: 424 EFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTL 483 E +LQ ++L + E +Q + M K +EE+ + E +E + + Sbjct: 1506 EEEMLQEDKKL---KWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVT 1562 Query: 484 DDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNR 543 ++ + ++ +K A A ++ Q+ ++L QE +EK +Q + A E Sbjct: 1563 EEQRHIQEEHKWARIHRKRARAE-----KKRAQEERKLAQE-EEKLAQEERQLAQEERKL 1616 Query: 544 SKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQ 603 ++ ++ + E Q E ++ + +L + +++ +KRK + ++ Sbjct: 1617 AQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLA--------QKRKKLAKK 1668 Query: 604 YTKNTAEQENLGK---KLREKQKVIRE--SHGPNMKQAKMWRDLEQLMECKK 650 + K E+E L K KL E + ++ + P +Q W++ E E ++ Sbjct: 1669 WEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEE 1720 Score = 44.3 bits (103), Expect = 4e-04 Identities = 84/474 (17%), Positives = 194/474 (40%), Gaps = 68/474 (14%) Query: 135 ETVADTNKQYEELMEAFKTLHKEYEQLK---------ISGFSTAEIRKDISAMEEEKDQL 185 E +A+T K+ ++ ++ ++ Q K + G DI+ E+ + Sbjct: 1907 EKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLE 1966 Query: 186 IKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQN 245 +KR+ K R+ + +++ E R+ + Q +QE + +++ ++ Sbjct: 1967 MKRLAEEKMRLVEGKE-----TLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHED 2021 Query: 246 QLKSMRQAA-ADAKPESLM-KRLEEEIKFNLYMVTEKFPKELENKKKE---LHFLQKVVS 300 ++ +M ++ A K E +R+ + + L + K K+ E+ KE L+ + K + Sbjct: 2022 RILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQ 2081 Query: 301 EPAMGHSDLLELESKINEINT-----EINQLIEKKMM----------RNEPIEGKLSLYR 345 + L + E K+ ++ E IE+ + R+E + + L R Sbjct: 2082 KLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLAR 2141 Query: 346 QQASIISRKKEA--KAEELQEAKEKLASLEREASVKRNQTREFDGTEVL----------- 392 +Q + ++ + K E++ E + KLA E + + + EV+ Sbjct: 2142 KQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRK 2201 Query: 393 ---KGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTM 449 +GD+ K K S+ + + E+++ L++ E L + E +++ + Sbjct: 2202 EAKRGDKPKE---KFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEERE 2258 Query: 450 EEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIK 509 EE+ +EE ++ E +E K + + E V++ + EK+ ++ Sbjct: 2259 EEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMS---- 2314 Query: 510 ELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESR 563 +E T+ +++ + +SC+ E +R K + +++ ++ LQE+ R Sbjct: 2315 ---------EEETESLSDEEEEEESCSLEEEVDREK--EILKKEKQFKLQEQRR 2357 Score = 38.1 bits (87), Expect = 0.027 Identities = 34/144 (23%), Positives = 66/144 (45%), Gaps = 11/144 (7%) Query: 170 EIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQ 229 E+ K S EE+++ + E ++ V + + + + +VEKE EE ++K+++ Sbjct: 2236 ELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKK 2295 Query: 230 KNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKK 289 K ++ Q + + + ++ + ESL EEE +L E+ +E E K Sbjct: 2296 KEEV-------QEKEEVFEEKEEIMSEEETESLSDEEEEEESCSL---EEEVDREKEILK 2345 Query: 290 KELHF-LQKVVSEPAMGHSDLLEL 312 KE F LQ+ + G +L + Sbjct: 2346 KEKQFKLQEQRRKSLRGRERVLSI 2369 >gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] Length = 1960 Score = 79.7 bits (195), Expect = 8e-15 Identities = 132/594 (22%), Positives = 251/594 (42%), Gaps = 115/594 (19%) Query: 111 ELKKRAYLARFLIKLEVPSEFLQDET------VADTN----KQYEELMEAFKTLHKEYEQ 160 E K+R L + KLE S L D+ +A+ K+ EEL A + +E Q Sbjct: 1039 EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ 1098 Query: 161 LKISGFSTAEIRKDISAMEEE--------------KDQLIKRVEHLKKRVETAQNHQWML 206 ++ E+ IS ++E+ K L + +E LK +E + Sbjct: 1099 KNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST--- 1155 Query: 207 KIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRL 266 ++LR ++E+E + ++ E++ + A Q++ MRQ + A E L ++L Sbjct: 1156 AAQQELRSKREQEVNILKKTLEEEAKTHEA---------QIQEMRQKHSQAV-EELAEQL 1205 Query: 267 EE--EIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSD---------LLELESK 315 E+ +K NL EK + LEN++ EL KV+ + G S+ L EL+ K Sbjct: 1206 EQTKRVKANL----EKAKQTLENERGELANEVKVLLQ-GKGDSEHKRKKVEAQLQELQVK 1260 Query: 316 INE---INTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASL 372 NE + TE+ + K + + + G LS ++S +++ A +LQ+ +E L Sbjct: 1261 FNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE 1320 Query: 373 EREA---SVKRNQTREFDGT--EVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGL 427 R+ S K Q + + E L+ +E ++ N + +T+ + + +++ G Sbjct: 1321 NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKH-NLEKQIATLHAQVADMKKKMEDSVGC 1379 Query: 428 LQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEM------KGR 481 L+ EE+ ++ ++++ Q EEK ++ Y ++ R L+ E+D++ + + Sbjct: 1380 LETAEEVKRKLQKDLEGLSQRHEEK--VAAYDKLEKTKTR---LQQELDDLLVDLDHQRQ 1434 Query: 482 TLDDMSEMVKKLYSLVSEKKSALASVIKE------------------------------- 510 + ++ + KK L++E+K+ A +E Sbjct: 1435 SACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE 1494 Query: 511 LRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCM 570 L +L ++++ ++ K LE ++ LEQ+V ++ + + E T Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDA 1554 Query: 571 IKNLEVQLRRATDEMKAYISSDQQ-------EKRKAIREQYTKNTAEQENLGKK 617 LEV L+ MKA D Q EK+K + Q + AE E+ K+ Sbjct: 1555 KLRLEVNLQ----AMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ 1604 Score = 77.0 bits (188), Expect = 5e-14 Identities = 101/561 (18%), Positives = 232/561 (41%), Gaps = 49/561 (8%) Query: 138 ADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVE 197 A+ K + + E + L +E + + +EEE Q+I ++ K E Sbjct: 936 AEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEE--QIILEDQNCKLAKE 993 Query: 198 TAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADA 257 + + L E+E+ + LA+ K + + + +RL+R + Q + + + Sbjct: 994 KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053 Query: 258 KPESL-MKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKI 316 + +S + E++ + + + K+ E + L +++ ++ M + ELES+I Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113 Query: 317 NEINTEI-------NQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKL 369 +E+ ++ N+ ++K E +E + + ++E +++ QE Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK 1173 Query: 370 ASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQII----AELKAEF 425 +LE EA Q +E +E + + + +K Q + EL E Sbjct: 1174 KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV 1233 Query: 426 GLLQRTEELLKQRHENIQQQLQTMEEK---------KGISGYSYTQEELERVSALKSEVD 476 +L + + + + + ++ QLQ ++ K + + Q EL+ V+ L S+ D Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD 1293 Query: 477 EMKGRTLDDMSEM------VKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKS 530 + D S + ++L + +K +L++ +K++ + ++E +E +E K Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKH 1353 Query: 531 QYDSCAAGLESN----RSKLE---------QEVRRLREECLQEESRYHYTNC----MIKN 573 + A L + + K+E +EV+R ++ L+ S+ H ++ Sbjct: 1354 NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413 Query: 574 LEVQLRRATDEMKAYISSDQQEKRKAIREQ--YTKNTAEQENLGKK-LREKQKVIRESHG 630 + +L++ D++ + +Q ++Q + + AE++ + K E+ + E+ Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE 1473 Query: 631 PNMKQAKMWRDLEQLMECKKQ 651 K + R LE+ ME K + Sbjct: 1474 KETKALSLARALEEAMEQKAE 1494 Score = 76.6 bits (187), Expect = 7e-14 Identities = 116/576 (20%), Positives = 240/576 (41%), Gaps = 55/576 (9%) Query: 124 KLEVPSEFLQDE-----TVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAM 178 +L+ E LQ+E +++ KQ E+ +F+ +E E+ K + + K I+ + Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHN------LEKQIATL 1362 Query: 179 EEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQ 238 + + K++E +ETA+ + L+ + ++ E+ A K E+ Q Sbjct: 1363 HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ--Q 1420 Query: 239 RLQRVQNQLKSMRQAAA--DAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQ 296 L + L RQ+A + K + + L EE + E+ E E ++KE L Sbjct: 1421 ELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALS 1480 Query: 297 KVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKE 356 A + +E ++++ +N + +E M + + GK + + K Sbjct: 1481 L-----ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDV-GK------SVHELEKSKR 1528 Query: 357 AKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQ 416 A ++++E K +L LE E + + +F+R + R + + KKK Sbjct: 1529 ALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQG-RDEQSEEKKKQL 1587 Query: 417 I--IAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSE 474 + + E++AE ++ + + ++ L+ +E S E ++++ L+++ Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHID-SANKNRDEAIKQLRKLQAQ 1646 Query: 475 VDEMKGRTLDDM-----------SEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQ 523 + + R LDD E KKL S+ +E + R RQ QE + Sbjct: 1647 MKDCM-RELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDE 1705 Query: 524 ECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATD 583 DE + A LE R +LE + +L EE +E+ N +K +Q+ + Sbjct: 1706 LADEIANSSGKGALALEEKR-RLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINT 1764 Query: 584 EMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMK--QAKMWRD 641 ++ + +K + R+Q + E L KL+E + ++ + ++ +AK+ + Sbjct: 1765 DLN--LERSHAQKNENARQQLERQNKE---LKVKLQEMEGTVKSKYKASITALEAKIAQL 1819 Query: 642 LEQL----MECKKQCFLKQQSQTSIGQVIQEGGEDR 673 EQL E + C ++++ + V+ + ++R Sbjct: 1820 EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDER 1855 Score = 57.0 bits (136), Expect = 6e-08 Identities = 83/409 (20%), Positives = 182/409 (44%), Gaps = 56/409 (13%) Query: 134 DETVADTNKQYEELMEAFKTLHKEYEQLKIS-GFSTAEIRKDISAM----EEEKDQLIKR 188 ++ V + Q EEL + + +L+++ A+ +D+ EE+K QL+++ Sbjct: 1531 EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQ 1590 Query: 189 VEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLK 248 V ++ +E + + M AR+ ++E + ++ A KN+ A+++L+++Q Q+K Sbjct: 1591 VREMEAELEDERKQRSMAVAARK-KLEMDLKDLEAHIDSANKNR-DEAIKQLRKLQAQMK 1648 Query: 249 -----------SMRQAAADAKP--------ESLMKRLEEEIKFNLYMVTEKFPKELENKK 289 S + A AK E+ M +L+EE+ E+ ++ + ++ Sbjct: 1649 DCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEEL-----AAAERAKRQAQQER 1703 Query: 290 KEL-HFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQA 348 EL + + A+ + LE++I ++ E+ + + N+ ++ K +L Q Sbjct: 1704 DELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK-KANLQIDQI 1762 Query: 349 SIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKS 408 + + + A++ + A+++L +E VK +E +GT K +K + L +K Sbjct: 1763 NTDLNLERSHAQKNENARQQLERQNKELKVK---LQEMEGTVKSK---YKASITALEAKI 1816 Query: 409 TVFKKK-HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYT------ 461 +++ E +A ++RTE+ LK + + + E+ K + + T Sbjct: 1817 AQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLK 1876 Query: 462 ------QEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSAL 504 +EE +R +A + ++ R L+D +E + VS K+ L Sbjct: 1877 RQLEEAEEEAQRANASRRKLQ----RELEDATETADAMNREVSSLKNKL 1921 Score = 51.6 bits (122), Expect = 2e-06 Identities = 87/454 (19%), Positives = 195/454 (42%), Gaps = 68/454 (14%) Query: 221 YLAQQKQEQKNQLFHAVQRLQRVQNQLKSMR-----QAAADAKPESLMKRLEEEIKFNLY 275 YLA++ ++ Q A++ LQR +R + KP + R EEE+ Sbjct: 793 YLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEE 852 Query: 276 MVTEKFPKEL--ENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMR 333 + + K+L EN+ E+ LQ + + + L+ E+++ Sbjct: 853 ELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETEL--------------CAE 898 Query: 334 NEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLK 393 E + +L+ +Q+ I EA+ EE +E + L +A K+ Q + E L+ Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHL-----QAEKKKMQQNIQELEEQLE 953 Query: 394 GDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKK 453 +E R +L +T K K L+ + +L+ ++ + ++ + +E++ Sbjct: 954 EEESARQKLQLEKVTTEAKLKK------------LEEEQIILEDQNCKLAKEKKLLEDRI 1001 Query: 454 GISGYSYTQEE--LERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKEL 511 + T+EE + ++ LK++ + M + D+ E +++ E+K +EL Sbjct: 1002 AEFTTNLTEEEEKSKSLAKLKNKHEAM----ITDLEERLRR------EEKQR-----QEL 1046 Query: 512 RQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMI 571 + R+K + + + ++ ++ + A L+ +K E+E++ +E ++ + I Sbjct: 1047 EKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKI 1106 Query: 572 KNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGP 631 + LE Q+ S+ QE ++ R K ++ +LG++L + + ++ Sbjct: 1107 RELESQI------------SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDS 1154 Query: 632 NMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQV 665 Q ++ EQ + K+ L+++++T Q+ Sbjct: 1155 TAAQQELRSKREQEVNILKKT-LEEEAKTHEAQI 1187 >gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens] Length = 1116 Score = 79.7 bits (195), Expect = 8e-15 Identities = 140/622 (22%), Positives = 268/622 (43%), Gaps = 82/622 (13%) Query: 94 SKPVIYPVLHWLLQRTNE---LKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEA 150 SK I+ + ++Q N+ + +A I+ ++ F QD + EL E Sbjct: 206 SKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEE 265 Query: 151 -FKTLHKEYEQLKISGFSTAEIRKDISA-MEEEKDQLIKRVEHLKKRVE----------- 197 F+ LH E+E+ F + +++ +E +K L R E +KK +E Sbjct: 266 NFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKA 325 Query: 198 TAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAA-- 255 T ++H+ ++A + + E L +QK+++ + L + R R +N S + A Sbjct: 326 TEEDHERTRRLA-EAEMHVHHLESLLEQKEKENSMLREEMHR--RFENAPDSAKTKALQT 382 Query: 256 -----DAKPESL---MKRLEEEI---KFNLYMVTEKFPKELE-------NKKKELHFLQK 297 D+K S+ ++ LEEEI K N + TE+ +E++ + K + +++ Sbjct: 383 VIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQ 442 Query: 298 VVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEP----IEGKLSLYRQQASIISR 353 + E + + EL+ K + EI Q +++++ R + ++ KL Q S + Sbjct: 443 LKEELSSKEAQWEELKKKAAGLQAEIGQ-VKQELSRKDTELLALQTKLETLTNQFSDSKQ 501 Query: 354 KKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKK 413 E E L +++ A L+ E R + E E + + K+ + K T + Sbjct: 502 HIEVLKESLTAKEQRAAILQTEVDALRLRLEE---KETMLNKKTKQIQDMAEEKGTQAGE 558 Query: 414 KHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEE-----KKGISGYSYTQEELERV 468 H +LK + +R +L+++ EN+Q+QL+ E+ K+ + + Sbjct: 559 IH----DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 614 Query: 469 SALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEK 528 E K RT++ + E + EK+ + + K+L+ L++K L + EK Sbjct: 615 LTTLEEALAEKERTIERLKEQRDR---DEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEK 671 Query: 529 K----------SQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQL 578 + S S +S LE + + +EECL+ ES+ + K E L Sbjct: 672 EASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQ------LKKAHEAAL 725 Query: 579 R-RATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAK 637 RA+ EM I ++E + +++ +K AE + L + L+E V E + + K A+ Sbjct: 726 EARASPEMSDRIQHLEREITR-YKDESSKAQAEVDRLLEILKE---VENEKNDKDKKIAE 781 Query: 638 MWRDLEQLMECKKQCFLKQQSQ 659 + R ++ + KK LK + Q Sbjct: 782 LERQVKD--QNKKVANLKHKEQ 801 Score = 60.8 bits (146), Expect = 4e-09 Identities = 104/484 (21%), Positives = 202/484 (41%), Gaps = 66/484 (13%) Query: 132 LQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEH 191 LQ +T +T+ L EA + E+LK + +D +EE D K ++ Sbjct: 604 LQADTT-NTDTALTTLEEALAEKERTIERLK------EQRDRDEREKQEEIDNYKKDLKD 656 Query: 192 LKKRVETAQNHQWMLKIARQLRVEKEREEYLAQ---QKQEQKNQLFHAVQRLQ----RVQ 244 LK++V Q + + L KE LA +K + L A+++ + +++ Sbjct: 657 LKEKVSLLQGD--LSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKME 714 Query: 245 NQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAM 304 +QLK +AA +A+ M + ++ + ++ K + L L++V +E Sbjct: 715 SQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKND 774 Query: 305 GHSDLLELESKINEINTEINQLIEKKMMRNEPI----------EGKLSLYRQQASIISRK 354 + ELE ++ + N ++ L K+ + + E L+ QQ RK Sbjct: 775 KDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRK 834 Query: 355 KEAKAEELQEA--------KEKLASLEREASVKRNQTREFD----GTEVLKGDEFKRYVN 402 K+ + EEL+EA E+ L +E S + N ++ + E +K E + Sbjct: 835 KDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVK-QELESMKA 893 Query: 403 KLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQ 462 KL S +K + L+AE + EE+L+ + E + + + + S ++ Sbjct: 894 KLSSTQQSLAEKETHLTNLRAE--RRKHLEEVLEMKQEALLAAISEKDANIALLELSSSK 951 Query: 463 EEL-ERVSALKSE----VDEMKGRTLDDMSEMV--------KKLYSLVSEKKSALASVIK 509 ++ E V+ALK E V ++K +T + M M K +S + K + +I+ Sbjct: 952 KKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQ 1011 Query: 510 ELRQLRQKYQE-------LTQECDEK-----KSQYDSCAAGLESNRSKLEQEVRRLREEC 557 L +L Q + LT C ++ + + L+ +++ E E++++ Sbjct: 1012 PLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQ 1071 Query: 558 LQEE 561 LQ+E Sbjct: 1072 LQDE 1075 >gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like protein 6 [Homo sapiens] Length = 724 Score = 79.7 bits (195), Expect = 8e-15 Identities = 99/498 (19%), Positives = 221/498 (44%), Gaps = 87/498 (17%) Query: 169 AEIRKDISAMEEEKDQLIKRVEHLKKRVETAQ------------NH--QWMLKIARQLRV 214 A++++ + +E EK ++ V+ LK+++E A+ +H + + ++ +L+ Sbjct: 285 AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA 344 Query: 215 EKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNL 274 + E E + Q+Q+ +++ +++Q + +++ + + E ++ EE+++ Sbjct: 345 QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ--EEKIREQEEKMRRQE 402 Query: 275 YMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRN 334 M+ EK K ++ +K+ + M + E E KI E+ E+KM Sbjct: 403 EMMWEKEEKMRRQEEMMWEKEEKMRRQEEM----MWEKEEKIREL--------EEKMHEQ 450 Query: 335 EPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKG 394 E I R++E K +E ++ +E+ E+EA + R + + + E ++ Sbjct: 451 EKI---------------REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 495 Query: 395 DEFK--RYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEK 452 E K R K+ + + +++ + Q EE+ +Q E I++Q + +K Sbjct: 496 QEEKMWRQEEKIHEQEKIREEEKR------------QEQEEMWRQE-EKIREQEEIWRQK 542 Query: 453 KGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELR 512 + I + QEE R K E K + D E +++ V ++ + +++R Sbjct: 543 EKI----HEQEEKIRKQEEKMWRQEEK---MHDQEEKIREQEEKVWRQEEKIREQEEKIR 595 Query: 513 QLRQKY---QELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNC 569 + +K +E+TQE +EK + + E + E+++RR E+ ++E + Sbjct: 596 EQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKK------ 649 Query: 570 MIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESH 629 I+ E ++R + M QE+ + + EQ K ++E K++E+++ +R Sbjct: 650 -IREQEEKIREQEEMM--------QEQEEKMWEQEEKMCEQEE----KMQEQEEKMRRQE 696 Query: 630 GPNMKQAKMWRDLEQLME 647 +Q R E+ M+ Sbjct: 697 EKMWEQEVRLRQQEEKMQ 714 Score = 74.7 bits (182), Expect = 3e-13 Identities = 105/523 (20%), Positives = 231/523 (44%), Gaps = 68/523 (13%) Query: 149 EAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI 208 EA + + ++ K +G E+ + +SA+ +K + + +E L K + L++ Sbjct: 220 EARDLISRLHDSWKFAG----ELEQALSAVATQKKKADRYIEELTKERDALS-----LEL 270 Query: 209 ARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEE 268 R ++E +E A K ++K QL + + +Q +K +++ AK Sbjct: 271 YRNTITDEELKEKNA--KLQEKLQLVESEK--SEIQLNVKELKRKLERAK---------- 316 Query: 269 EIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIE 328 L + ++ E ++ KEL + S L+ + + NE+ +NQ E Sbjct: 317 -----LLLPQQQLQAEADHLGKELQSV-----------SAKLQAQVEENELWNRLNQQQE 360 Query: 329 KKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDG 388 +KM R E K+ + + K + + E+++E +EK+ E+E ++R + ++ Sbjct: 361 EKMWRQEE---KIQEWEE-------KIQEQEEKIREQEEKIR--EQEEKMRRQEEMMWEK 408 Query: 389 TEVLKGDEFKRYVN--KLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQL 446 E ++ E + K+R + + +K + I EL+ + ++ E ++R E ++++ Sbjct: 409 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE--EEKI 466 Query: 447 QTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALAS 506 + E+++ + QEE R K E K ++ +K+ EK+ Sbjct: 467 REQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIRE--EEKRQEQEE 524 Query: 507 VIKELRQLRQ-----KYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEE 561 + ++ ++R+ + +E E +EK + + E E+++R E+ ++E Sbjct: 525 MWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQE 584 Query: 562 SRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGK---KL 618 + I+ E ++R +EM E+ + + EQ K ++E + + K+ Sbjct: 585 EKIREQEEKIREQEEKIREQ-EEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKI 643 Query: 619 REKQKVIRESHGPNMKQAKMWRDLEQLM--ECKKQCFLKQQSQ 659 RE++K IRE +Q +M ++ E+ M + +K C +++ Q Sbjct: 644 REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ 686 Score = 72.4 bits (176), Expect = 1e-12 Identities = 102/485 (21%), Positives = 212/485 (43%), Gaps = 52/485 (10%) Query: 197 ETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAAD 256 E +HQ + R+L + L QK E + L+++ Q+ +K + A D Sbjct: 171 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYS-------QHAVKQLEGEARD 223 Query: 257 AKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKI 316 L+ RL + KF + + KKK +++++ E D L LE Sbjct: 224 -----LISRLHDSWKF-AGELEQALSAVATQKKKADRYIEELTKE-----RDALSLELYR 272 Query: 317 NEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLAS--LER 374 N I E +L EK N ++ KL L + S I + +L+ AK L L+ Sbjct: 273 NTITDE--ELKEK----NAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA 326 Query: 375 EASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEEL 434 EA + + + +E + + + + ++ + I E + + +Q EE Sbjct: 327 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK---IQEQEEK 383 Query: 435 LKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLY 494 ++++ E I++Q + M ++ + +E++ R + E +E R + M E +K+ Sbjct: 384 IREQEEKIREQEEKMRRQEEMMWEK--EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 441 Query: 495 SLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLR 554 L E+K I+E + RQ+ +++ ++ EK+ + ++ E + E+++R Sbjct: 442 EL--EEKMHEQEKIREQEEKRQEEEKIREQ--EKRQEQEAKMWRQEEKIREQEEKIREQE 497 Query: 555 EECLQEESRYHYTNCMIKNLEVQLRRATDEM-----KAYISSDQQEKRKAIREQYTKNTA 609 E+ ++E + H K E + R+ +EM K + +++ I EQ K Sbjct: 498 EKMWRQEEKIHEQE---KIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRK 554 Query: 610 EQENLGK---KLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQTSIGQVI 666 ++E + + K+ ++++ IRE ++ K+WR E++ E +++ +++ ++ Sbjct: 555 QEEKMWRQEEKMHDQEEKIRE------QEEKVWRQEEKIREQEEKIREQEEKIREQEEMT 608 Query: 667 QEGGE 671 QE E Sbjct: 609 QEQEE 613 Score = 70.1 bits (170), Expect = 6e-12 Identities = 96/437 (21%), Positives = 193/437 (44%), Gaps = 50/437 (11%) Query: 226 KQEQKNQLFHAVQRLQRVQNQLK-SMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKE 284 K+ ++++L A ++L Q S+ AA+D K + + E T Sbjct: 114 KETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPET------TTSGGCHS 167 Query: 285 LENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLY 344 E+++K H Q+ + ELE++++ I Q E +M L Sbjct: 168 PEDEQKASHQHQEALRR---------ELEAQVHTIRILTCQKTELQMALYYSQHAVKQLE 218 Query: 345 RQQASIISRKKEAK--AEELQEAKEKLASLEREASVKRNQ-TREFDGTEVLKGDEFKRYV 401 + +ISR ++ A EL++A +A+ +++A + T+E D + + ++ + Sbjct: 219 GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSL---ELYRNTI 275 Query: 402 N--KLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENI-----QQQLQTMEEKKG 454 +L+ K+ ++K Q++ K+E +Q + LK++ E QQQLQ + G Sbjct: 276 TDEELKEKNAKLQEKLQLVESEKSE---IQLNVKELKRKLERAKLLLPQQQLQAEADHLG 332 Query: 455 ISGYSYTQEELERVSA-LKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQ 513 +EL+ VSA L+++V+E +E+ +L EK I+E + Sbjct: 333 --------KELQSVSAKLQAQVEE---------NELWNRLNQQQEEKMWRQEEKIQEWEE 375 Query: 514 LRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKN 573 Q+ +E +E +EK + + E + E+++RR E ++E + M+ Sbjct: 376 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 435 Query: 574 LEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNM 633 E ++R ++M +QE+++ E+ + QE K R+++K+ + Sbjct: 436 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 495 Query: 634 KQAKMWRDLEQLMECKK 650 ++ KMWR E++ E +K Sbjct: 496 QEEKMWRQEEKIHEQEK 512 Score = 59.7 bits (143), Expect = 9e-09 Identities = 68/388 (17%), Positives = 181/388 (46%), Gaps = 33/388 (8%) Query: 123 IKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEK 182 + ++ ++ ++E N+Q EE M + +E+E+ KI +IR+ + E++ Sbjct: 338 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEE-KIQE-QEEKIREQEEKIREQE 395 Query: 183 DQLIKRVEHLKKRVETAQNHQWML-----KIARQLRVEKEREEYLAQQKQEQKNQLFHAV 237 +++ ++ E + ++ E + + M+ K+ RQ + E+EE + + +++ Q + Sbjct: 396 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ--EKI 453 Query: 238 QRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQK 297 + + + + + +R+ + E+ M R EE+I+ + E+ +++ +++++H +K Sbjct: 454 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ-EEKMWRQEEKIHEQEK 512 Query: 298 V--------------VSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSL 343 + E ++ + KI+E +I + EK + E + + Sbjct: 513 IREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEK 572 Query: 344 YRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNK 403 R+Q + R++ E+++E +EK+ E + + T+E + + ++ K Sbjct: 573 IREQEEKVWRQE----EKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK 628 Query: 404 LRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTM--EEKKGISGYSYT 461 ++ + +++ + I E + + ++ EE ++++ E +Q+Q + M +E+K Sbjct: 629 MQEQEEKMRRQEEKIREQEKK---IREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 685 Query: 462 QEELERVSALKSEVDEMKGRTLDDMSEM 489 QE+ E++ + ++ E + R +M Sbjct: 686 QEQEEKMRRQEEKMWEQEVRLRQQEEKM 713 Score = 44.7 bits (104), Expect = 3e-04 Identities = 67/330 (20%), Positives = 144/330 (43%), Gaps = 43/330 (13%) Query: 355 KEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNK-LRSKSTVFKK 413 KE + +L EAKE+L QT GT D K+ +N ++T Sbjct: 114 KETRQSKLAEAKEQLTD-------HHPQTNPSVGTAA--SDTKKKKINNGTNPETTTSGG 164 Query: 414 KHQIIAELKAEFGLLQRTEELLKQRHENIQQ-QLQTMEEKKGISGYSYTQEELERVSALK 472 H E KA Q E L ++ + ++ T ++ + Y+Q +++ L+ Sbjct: 165 CHSPEDEQKASH---QHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQ---LE 218 Query: 473 SEVDEMKGRTLDDMS---EMVKKLYSLVSEKKSA---LASVIKELRQLRQKYQELT---Q 523 E ++ R D E+ + L ++ ++KK A + + KE L + T + Sbjct: 219 GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE 278 Query: 524 ECDEKKSQYDSCAAGLESNRSKLEQEVRRLREEC---------LQEESRYHYTNCMIKNL 574 E EK ++ +ES +S+++ V+ L+ + Q ++ + ++++ Sbjct: 279 ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 338 Query: 575 EVQLRRATDEMKAYISSDQQEKRKAIREQ-----YTKNTAEQENLGKKLREKQKVIRESH 629 +L+ +E + + +QQ++ K R++ + + EQE +K+RE+++ IRE Sbjct: 339 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE---EKIREQEEKIREQE 395 Query: 630 GPNMKQAKMWRDLEQLMECKKQCFLKQQSQ 659 +Q +M + E+ M +++ +++ + Sbjct: 396 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 425 >gi|38044112 restin isoform b [Homo sapiens] Length = 1392 Score = 79.3 bits (194), Expect = 1e-14 Identities = 125/534 (23%), Positives = 225/534 (42%), Gaps = 95/534 (17%) Query: 146 ELMEAFKTLHKEYEQLKIS---GFST-----AEIRKDISAMEEEKDQLIKRVEHLKKRVE 197 +L A + + E+LK+S G T AE++ I M + I+ +++ + Sbjct: 580 KLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSER 639 Query: 198 TAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAV-QRLQRVQNQLKSMRQAAAD 256 A + A+ ++V KE+E L + +++L A Q L +++ L +++A Sbjct: 640 AAHAKEMEALRAKLMKVIKEKENSL----EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 695 Query: 257 AKP-ESLMKRLEEEIKFNLYMVTEKFPKEL---ENKKKELHFLQKVVSEPAMGHSDLLEL 312 K E L + E+ K V + F +L E K +L L+K SE G S++ +L Sbjct: 696 VKELEVLQAKCNEQTK-----VIDNFTSQLKATEEKLLDLDALRKASSE---GKSEMKKL 747 Query: 313 -------ESKINEINTEINQLIEKKMMRNEPIEG---KLSLYRQQASIISRKKEAKAEEL 362 E +I + E N K ++G KL+ ++ S +S+ KE +EL Sbjct: 748 RQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL 807 Query: 363 QEAKEKLASLEREA-SVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVF-------KKK 414 Q KEK A EA SV+R+ + VNKL K F +K Sbjct: 808 QILKEKFAEASEEAVSVQRSM---------------QETVNKLHQKEEQFNMLSSDLEKL 852 Query: 415 HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSE 474 + +A+++A+F EE L + E ++ + + + G + S L Sbjct: 853 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG-----------DNSSQLTKM 901 Query: 475 VDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELR-QLRQKYQELTQECDEKKSQYD 533 DE++ + D + E+ KL + +E S L I+++ + Q QE ++ +E+K + Sbjct: 902 NDELRLKERD-VEELQLKL-TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE-- 957 Query: 534 SCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQ 593 LE S LE+++ +C + ++RY RAT E K Sbjct: 958 -----LERKLSDLEKKMETSHNQCQELKARYE--------------RATSETKTKHEEIL 998 Query: 594 QEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLME 647 Q +K + + K +E L+E +++ +++ K A+ D Q+ME Sbjct: 999 QNLQKTLLDTEDKLKGAREENSGLLQELEELRKQA--DKAKAAQTAEDAMQIME 1050 Score = 78.6 bits (192), Expect = 2e-14 Identities = 137/668 (20%), Positives = 261/668 (39%), Gaps = 121/668 (18%) Query: 27 DSLEPMQLLQVLSDVLAEIDPK-----QLVDIREEMPEQTAKRMLSLLGILKYKPSGNAT 81 D+L +Q ++ L + K +++D + T +++L L + K G + Sbjct: 684 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKS- 742 Query: 82 DMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQD------- 134 +M RQ L K + H +++ E K + + R L E+ LQ+ Sbjct: 743 EMKKLRQQLEAAEKQI----KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ 798 Query: 135 -------------ETVADTNKQ----YEELMEAFKTLHKEYEQLKISGFSTAEIRKDISA 177 E A+ +++ + E LH++ EQ + ++R++++ Sbjct: 799 VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 858 Query: 178 ME-------EEKDQLIKRVEHLKKRVE-----TAQNHQWMLKIARQLRVEKEREEYLAQQ 225 ME E ++QLIK E L+ + + N + K+ +LR+ KER+ Sbjct: 859 MEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL-KERDV----- 912 Query: 226 KQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKEL 285 +E + +L A + +Q ++ M A ++ E+ K EE K L K++ Sbjct: 913 -EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEE--KKELERKLSDLEKKM 969 Query: 286 ENKKKELHFL----QKVVSEPAMGHSD--------LLELESKINEINTEINQLIEK-KMM 332 E + L ++ SE H + LL+ E K+ E + L+++ + + Sbjct: 970 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1029 Query: 333 RNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVL 392 R + + K + + A I + +E E LASLE E D L Sbjct: 1030 RKQADKAKAAQTAEDAMQIMEQMT------KEKTETLASLEDTKQTNAKLQNELD---TL 1080 Query: 393 KGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLL-----QRTEELLKQRHENIQQQLQ 447 K + K V +L + ++Q + E + E L Q++++L + EN++ + Sbjct: 1081 KENNLKN-VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE 1139 Query: 448 TMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASV 507 + ++ + +EE ++ E+ + + + + D E L +S + L Sbjct: 1140 LGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1199 Query: 508 IKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLR------------- 554 EL +LR + L E KS + S LES++ KLE +V+ L Sbjct: 1200 DAELEKLRNEVTVLRGENASAKSLH-SVVQTLESDKVKLELKVKNLELQLKENKRQLSSS 1258 Query: 555 ---------EECLQEESRYHYTNCMIKNL---------------EVQLRRATDEMKAYIS 590 E+ +ES+ + N +I +L E L D++ Y S Sbjct: 1259 SGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDS 1318 Query: 591 SDQQEKRK 598 DQ+++ K Sbjct: 1319 DDQEKQSK 1326 Score = 65.1 bits (157), Expect = 2e-10 Identities = 121/593 (20%), Positives = 242/593 (40%), Gaps = 88/593 (14%) Query: 105 LLQRTNELKKRAYLARFLIKLE-VPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKI 163 LL + E K++ +F ++ E + L+ TV++ ++ +ME K L +++ Sbjct: 427 LLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSR----IMELEKDLALRVQEV-- 480 Query: 164 SGFSTAEIRKDISAMEEEKD-----QLIKRVEHLKKRVE-TAQNHQWMLKIARQLRVEKE 217 AE+R+ + + + D L++ + L++++E T +HQ R++ KE Sbjct: 481 -----AELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQ------REITSLKE 529 Query: 218 REEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAA-----------------ADAKPE 260 + Q++ L+ A ++L + LKS + A A A + Sbjct: 530 HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQ 589 Query: 261 SLMKRLEEEIKFNLYMVTEKFPK-ELENKKKELHFLQKVVSEPAMGHSDLLELESKINEI 319 M+ L+ L T +F + + + +K L + ++ + S+ ++ + Sbjct: 590 QAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL 649 Query: 320 NTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVK 379 ++ ++I++K E I KL Q + + E +LQEA+ K+ LE + Sbjct: 650 RAKLMKVIKEKENSLEAIRSKLDKAEDQHLV---EMEDTLNKLQEAEIKVKELEVLQAKC 706 Query: 380 RNQTREFDG-TEVLKGDEFKRY-VNKLRSKSTV----FKKKHQIIAELKAEFGLLQRTEE 433 QT+ D T LK E K ++ LR S+ KK Q + + + L+ + Sbjct: 707 NEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKN 766 Query: 434 LLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKL 493 + +I ++LQ E K + QE L VS +K TL+ +++K+ Sbjct: 767 AESSKASSITRELQGRELK-----LTNLQENLSEVSQVKE--------TLEKELQILKEK 813 Query: 494 YSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRL 553 ++ SE E +++ QE + +K+ Q++ ++ LE R L + Sbjct: 814 FAEASE----------EAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 863 Query: 554 REECLQEESRYHYTNCMIKNLEVQLRRATDEMK--AYISSDQQEKRKAIREQYTKNTAEQ 611 RE+ +EE + ++ ++ + D ++ + + K + + E K T Sbjct: 864 REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKAN 923 Query: 612 EN----------LGKKLREKQKVIRESHGPNMKQ-AKMWRDLEQLMECK-KQC 652 EN + K + Q+ + H K+ + DLE+ ME QC Sbjct: 924 ENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQC 976 Score = 55.1 bits (131), Expect = 2e-07 Identities = 108/505 (21%), Positives = 211/505 (41%), Gaps = 93/505 (18%) Query: 162 KISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEY 221 KISG T +++ + ++ +QL+ + + V A +H E E+E Sbjct: 346 KISG--TTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVG----------EIEQELA 393 Query: 222 LAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKF 281 LA+ +Q V L+ +QL++M + AAD + L+ +LEEE Sbjct: 394 LARDGHDQH------VLELEAKMDQLRTMVE-AADREKVELLNQLEEE------------ 434 Query: 282 PKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKL 341 K+++ LQ V E ++ DL E+ + EK R +E L Sbjct: 435 -------KRKVEDLQFRVEEESITKGDL------------EVATVSEKS--RIMELEKDL 473 Query: 342 SLYRQQASIISRKKEAK-----AEELQEAKEKLASLEREASVKR-NQTREFDGTEVLKGD 395 +L Q+ + + R+ E+ + ++++SL+ + V R + RE + G Sbjct: 474 ALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGA 533 Query: 396 EFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEE----LLKQRHEN-IQQQLQTME 450 + + ++++ T +K + LK++ + L K + E I Q ME Sbjct: 534 REETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAME 593 Query: 451 EKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKE 510 E K +S E + LK+++++M+ LD E + +L +++ S A+ KE Sbjct: 594 ELK-VSFSKGLGTETAEFAELKTQIEKMR---LDYQHE----IENLQNQQDSERAAHAKE 645 Query: 511 LRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCM 570 + LR K ++ +E + LE+ RSKL++ + E ++ Sbjct: 646 MEALRAKLMKVIKEKEN----------SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 695 Query: 571 IKNLEVQLRRATDEMKAYISSDQQEKR--------KAIREQYTKNTAEQENLGKKLREKQ 622 +K LEV + ++ K + Q K A+R+ ++ +E + L ++L + Sbjct: 696 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAE 755 Query: 623 KVIR----ESHGPNMKQAKMWRDLE 643 K I+ E + + K + + R+L+ Sbjct: 756 KQIKHLEIEKNAESSKASSITRELQ 780 >gi|4506751 restin isoform a [Homo sapiens] Length = 1427 Score = 79.3 bits (194), Expect = 1e-14 Identities = 125/534 (23%), Positives = 225/534 (42%), Gaps = 95/534 (17%) Query: 146 ELMEAFKTLHKEYEQLKIS---GFST-----AEIRKDISAMEEEKDQLIKRVEHLKKRVE 197 +L A + + E+LK+S G T AE++ I M + I+ +++ + Sbjct: 615 KLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSER 674 Query: 198 TAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAV-QRLQRVQNQLKSMRQAAAD 256 A + A+ ++V KE+E L + +++L A Q L +++ L +++A Sbjct: 675 AAHAKEMEALRAKLMKVIKEKENSL----EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 730 Query: 257 AKP-ESLMKRLEEEIKFNLYMVTEKFPKEL---ENKKKELHFLQKVVSEPAMGHSDLLEL 312 K E L + E+ K V + F +L E K +L L+K SE G S++ +L Sbjct: 731 VKELEVLQAKCNEQTK-----VIDNFTSQLKATEEKLLDLDALRKASSE---GKSEMKKL 782 Query: 313 -------ESKINEINTEINQLIEKKMMRNEPIEG---KLSLYRQQASIISRKKEAKAEEL 362 E +I + E N K ++G KL+ ++ S +S+ KE +EL Sbjct: 783 RQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL 842 Query: 363 QEAKEKLASLEREA-SVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVF-------KKK 414 Q KEK A EA SV+R+ + VNKL K F +K Sbjct: 843 QILKEKFAEASEEAVSVQRSM---------------QETVNKLHQKEEQFNMLSSDLEKL 887 Query: 415 HQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSE 474 + +A+++A+F EE L + E ++ + + + G + S L Sbjct: 888 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG-----------DNSSQLTKM 936 Query: 475 VDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELR-QLRQKYQELTQECDEKKSQYD 533 DE++ + D + E+ KL + +E S L I+++ + Q QE ++ +E+K + Sbjct: 937 NDELRLKERD-VEELQLKL-TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE-- 992 Query: 534 SCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQ 593 LE S LE+++ +C + ++RY RAT E K Sbjct: 993 -----LERKLSDLEKKMETSHNQCQELKARYE--------------RATSETKTKHEEIL 1033 Query: 594 QEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLME 647 Q +K + + K +E L+E +++ +++ K A+ D Q+ME Sbjct: 1034 QNLQKTLLDTEDKLKGAREENSGLLQELEELRKQA--DKAKAAQTAEDAMQIME 1085 Score = 78.6 bits (192), Expect = 2e-14 Identities = 137/668 (20%), Positives = 261/668 (39%), Gaps = 121/668 (18%) Query: 27 DSLEPMQLLQVLSDVLAEIDPK-----QLVDIREEMPEQTAKRMLSLLGILKYKPSGNAT 81 D+L +Q ++ L + K +++D + T +++L L + K G + Sbjct: 719 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKS- 777 Query: 82 DMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQD------- 134 +M RQ L K + H +++ E K + + R L E+ LQ+ Sbjct: 778 EMKKLRQQLEAAEKQI----KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ 833 Query: 135 -------------ETVADTNKQ----YEELMEAFKTLHKEYEQLKISGFSTAEIRKDISA 177 E A+ +++ + E LH++ EQ + ++R++++ Sbjct: 834 VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 893 Query: 178 ME-------EEKDQLIKRVEHLKKRVE-----TAQNHQWMLKIARQLRVEKEREEYLAQQ 225 ME E ++QLIK E L+ + + N + K+ +LR+ KER+ Sbjct: 894 MEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL-KERDV----- 947 Query: 226 KQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKEL 285 +E + +L A + +Q ++ M A ++ E+ K EE K L K++ Sbjct: 948 -EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEE--KKELERKLSDLEKKM 1004 Query: 286 ENKKKELHFL----QKVVSEPAMGHSD--------LLELESKINEINTEINQLIEK-KMM 332 E + L ++ SE H + LL+ E K+ E + L+++ + + Sbjct: 1005 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1064 Query: 333 RNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVL 392 R + + K + + A I + +E E LASLE E D L Sbjct: 1065 RKQADKAKAAQTAEDAMQIMEQMT------KEKTETLASLEDTKQTNAKLQNELD---TL 1115 Query: 393 KGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLL-----QRTEELLKQRHENIQQQLQ 447 K + K V +L + ++Q + E + E L Q++++L + EN++ + Sbjct: 1116 KENNLKN-VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE 1174 Query: 448 TMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASV 507 + ++ + +EE ++ E+ + + + + D E L +S + L Sbjct: 1175 LGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1234 Query: 508 IKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLR------------- 554 EL +LR + L E KS + S LES++ KLE +V+ L Sbjct: 1235 DAELEKLRNEVTVLRGENASAKSLH-SVVQTLESDKVKLELKVKNLELQLKENKRQLSSS 1293 Query: 555 ---------EECLQEESRYHYTNCMIKNL---------------EVQLRRATDEMKAYIS 590 E+ +ES+ + N +I +L E L D++ Y S Sbjct: 1294 SGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDS 1353 Query: 591 SDQQEKRK 598 DQ+++ K Sbjct: 1354 DDQEKQSK 1361 Score = 66.6 bits (161), Expect = 7e-11 Identities = 124/611 (20%), Positives = 246/611 (40%), Gaps = 89/611 (14%) Query: 105 LLQRTNELKKRAYLARFLIKLE-VPSEFLQDETVADTN--KQYEELMEAFKT----LHKE 157 LL + E K++ +F ++ E + L+ +T + K+ E+ + KT L +E Sbjct: 427 LLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRE 486 Query: 158 YEQLKISGFSTA----EIRKDISAMEEEKDQLIKRVEHLK------------KRVETAQN 201 E +++ S E+ KD++ +E +L +R+E K + + + Q Sbjct: 487 LEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQE 546 Query: 202 HQWMLKIARQLRVEKEREEYLAQQKQEQKN--QLFHAVQRLQRVQNQLKSMRQAA----- 254 + + Q + +E + A+++ QK L+ A ++L + LKS + A Sbjct: 547 KLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENS 606 Query: 255 ------------ADAKPESLMKRLEEEIKFNLYMVTEKFPK-ELENKKKELHFLQKVVSE 301 A A + M+ L+ L T +F + + + +K L + ++ + Sbjct: 607 DVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENL 666 Query: 302 PAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEE 361 S+ ++ + ++ ++I++K E I KL Q + + E + Sbjct: 667 QNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLV---EMEDTLNK 723 Query: 362 LQEAKEKLASLEREASVKRNQTREFDG-TEVLKGDEFKRY-VNKLRSKSTV----FKKKH 415 LQEA+ K+ LE + QT+ D T LK E K ++ LR S+ KK Sbjct: 724 LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLR 783 Query: 416 QIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEV 475 Q + + + L+ + + +I ++LQ E K + QE L VS +K Sbjct: 784 QQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELK-----LTNLQENLSEVSQVKE-- 836 Query: 476 DEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSC 535 TL+ +++K+ ++ SE E +++ QE + +K+ Q++ Sbjct: 837 ------TLEKELQILKEKFAEASE----------EAVSVQRSMQETVNKLHQKEEQFNML 880 Query: 536 AAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMK--AYISSDQ 593 ++ LE R L + RE+ +EE + ++ ++ + D ++ + Sbjct: 881 SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 940 Query: 594 QEKRKAIREQYTKNTAEQEN----------LGKKLREKQKVIRESHGPNMKQ-AKMWRDL 642 + K + + E K T EN + K + Q+ + H K+ + DL Sbjct: 941 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 1000 Query: 643 EQLMECK-KQC 652 E+ ME QC Sbjct: 1001 EKKMETSHNQC 1011 Score = 60.1 bits (144), Expect = 7e-09 Identities = 108/525 (20%), Positives = 219/525 (41%), Gaps = 98/525 (18%) Query: 162 KISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEY 221 KISG T +++ + ++ +QL+ + + V A +H E E+E Sbjct: 346 KISG--TTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVG----------EIEQELA 393 Query: 222 LAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKF 281 LA+ +Q V L+ +QL++M + AAD + L+ +LEEE Sbjct: 394 LARDGHDQH------VLELEAKMDQLRTMVE-AADREKVELLNQLEEE------------ 434 Query: 282 PKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKL 341 K+++ LQ V E ++ D LE ++K+ + I +L E+ ++ + KL Sbjct: 435 -------KRKVEDLQFRVEEESITKGD-LETQTKLE--HARIKEL-EQSLLFEKTKADKL 483 Query: 342 SLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYV 401 + + + ++++ EL+ K+ ++ A ++R +V + + Sbjct: 484 QRELEDTRVATVSEKSRIMELE--KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEI 541 Query: 402 NKLRSKSTVFKKKHQ-IIAELKAEFGLLQRTE-----------ELLKQRHENIQQQLQTM 449 + L+ K V + HQ I LK FG + T E L + +E+++ +L+ Sbjct: 542 SSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHA 601 Query: 450 EEKK-------------GISGYSYTQEELERVSALK------SEVDEMKGRTLDDMSEMV 490 ++ I+ + EEL +VS K +E E+K + + Sbjct: 602 NKENSDVIALWKSKLETAIASHQQAMEEL-KVSFSKGLGTETAEFAELKTQIEKMRLDYQ 660 Query: 491 KKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEV 550 ++ +L +++ S A+ KE+ LR K ++ +E + LE+ RSKL++ Sbjct: 661 HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKEN----------SLEAIRSKLDKAE 710 Query: 551 RRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKR--------KAIRE 602 + E ++ +K LEV + ++ K + Q K A+R+ Sbjct: 711 DQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRK 770 Query: 603 QYTKNTAEQENLGKKLREKQKVIR----ESHGPNMKQAKMWRDLE 643 ++ +E + L ++L +K I+ E + + K + + R+L+ Sbjct: 771 ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQ 815 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.313 0.128 0.338 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 22,027,224 Number of Sequences: 37866 Number of extensions: 979001 Number of successful extensions: 12619 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 248 Number of HSP's successfully gapped in prelim test: 1144 Number of HSP's that attempted gapping in prelim test: 5653 Number of HSP's gapped (non-prelim): 4348 length of query: 676 length of database: 18,247,518 effective HSP length: 109 effective length of query: 567 effective length of database: 14,120,124 effective search space: 8006110308 effective search space used: 8006110308 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.