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Search of human proteins with 32306513
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
(673 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 1347 0.0
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 1309 0.0
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 981 0.0
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 981 0.0
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 981 0.0
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 931 0.0
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 928 0.0
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 928 0.0
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 922 0.0
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 918 0.0
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 887 0.0
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 828 0.0
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 744 0.0
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 247 2e-65
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 247 2e-65
gi|4826894 phosphodiesterase 1C [Homo sapiens] 239 5e-63
gi|4505677 phosphodiesterase 1B [Homo sapiens] 234 3e-61
gi|9506959 phosphodiesterase 7B [Homo sapiens] 228 1e-59
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 218 1e-56
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 218 1e-56
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 208 1e-53
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 208 1e-53
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 208 1e-53
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 208 1e-53
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 208 1e-53
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 208 1e-53
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 192 6e-49
gi|40254434 phosphodiesterase 3B [Homo sapiens] 188 2e-47
gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens] 177 2e-44
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 177 3e-44
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 1347 bits (3487), Expect = 0.0
Identities = 673/673 (100%), Positives = 673/673 (100%)
Query: 1 MMHVNNFPFRRHSWICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSD 60
MMHVNNFPFRRHSWICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSD
Sbjct: 1 MMHVNNFPFRRHSWICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSD 60
Query: 61 SDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSP 120
SDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSP
Sbjct: 61 SDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSP 120
Query: 121 MCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNREL 180
MCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNREL
Sbjct: 121 MCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNREL 180
Query: 181 THLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSL 240
THLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSL
Sbjct: 181 THLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSL 240
Query: 241 TNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKT 300
TNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKT
Sbjct: 241 TNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKT 300
Query: 301 FKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAI 360
FKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAI
Sbjct: 301 FKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAI 360
Query: 361 FASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTK 420
FASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTK
Sbjct: 361 FASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTK 420
Query: 421 KQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMV 480
KQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMV
Sbjct: 421 KQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMV 480
Query: 481 HCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID 540
HCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID
Sbjct: 481 HCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID 540
Query: 541 YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQF 600
YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQF
Sbjct: 541 YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQF 600
Query: 601 ELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQ 660
ELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQ
Sbjct: 601 ELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQ 660
Query: 661 PEACVIDDRSPDT 673
PEACVIDDRSPDT
Sbjct: 661 PEACVIDDRSPDT 673
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 1309 bits (3388), Expect = 0.0
Identities = 657/657 (100%), Positives = 657/657 (100%)
Query: 17 FDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSI 76
FDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSI
Sbjct: 153 FDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSI 212
Query: 77 ASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEA 136
ASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEA
Sbjct: 213 ASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEA 272
Query: 137 YQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEF 196
YQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEF
Sbjct: 273 YQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEF 332
Query: 197 ISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQED 256
ISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQED
Sbjct: 333 ISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQED 392
Query: 257 VLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLE 316
VLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLE
Sbjct: 393 VLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLE 452
Query: 317 DHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQ 376
DHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQ
Sbjct: 453 DHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQ 512
Query: 377 FLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLA 436
FLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLA
Sbjct: 513 FLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLA 572
Query: 437 TDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYR 496
TDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYR
Sbjct: 573 TDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYR 632
Query: 497 QWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHP 556
QWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHP
Sbjct: 633 QWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHP 692
Query: 557 DAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDS 616
DAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDS
Sbjct: 693 DAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDS 752
Query: 617 GSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT 673
GSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
Sbjct: 753 GSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT 809
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 981 bits (2535), Expect = 0.0
Identities = 496/629 (78%), Positives = 548/629 (87%), Gaps = 8/629 (1%)
Query: 16 CFDVDNGTSAGRSPLDPMTSPGSGLILQANFV-HSQRRESFLYRSDSDYDLSPKSMSRNS 74
CFDV+NG S GRSPLDP S +GL+L A F HSQRRESFLYRSDSDYDLSPK+MSRNS
Sbjct: 94 CFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNS 153
Query: 75 SIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITE 134
S+ S+ HGDDLIVTPFAQVLASLR+VRNNF LTNL + +KRSP +QP +++ E
Sbjct: 154 SLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTS-NKRSPAASQPPVSRVNPQE 212
Query: 135 EAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 194
E+YQKLA ETLEELDWCLDQLET+QT SVSEMASNKFKRMLNRELTHLSEMSRSGNQVS
Sbjct: 213 ESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 272
Query: 195 EFISNTFLDKQHEVEIPSPTQKEKEKKKRP--MSQISGVKKLMHSSSLTNSSIPRFGVKT 252
E+ISNTFLDKQ++VEIPSPTQK++EKKK+ M+QISGVKKLMHSSSL N+SI RFGV T
Sbjct: 273 EYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNT 332
Query: 253 EQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYL 312
E ED LAKELED+NKWGL++F +A S NRPLT IM+ IFQERDLLKTF+I DT ITY+
Sbjct: 333 ENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYM 392
Query: 313 MTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPG 372
MTLEDHYH+DVAYHN++HAADV QSTHVLLSTPAL+AVFTDLEILAAIFA+AIHDVDHPG
Sbjct: 393 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPG 452
Query: 373 VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVID 432
VSNQFLINTNSELALMYND SVLENHHLAVGFKLLQEE+CDIF NLTKKQRQ+LRKMVID
Sbjct: 453 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVID 512
Query: 433 IVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL 492
+VLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVL+NMVHCADLSNPTK L
Sbjct: 513 MVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSL 572
Query: 493 QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWAD 552
+LYRQWTDRIMEEFF+QGD+ERERGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWAD
Sbjct: 573 ELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 632
Query: 553 LVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDT 612
LV PDAQDILDTLEDNR WYQS IPQSPSP D+ QG EKFQFELTL+E+
Sbjct: 633 LVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGP 692
Query: 613 EKDSGSQVEEDTSCSDSKTLCTQDSESTE 641
EK+ E + S +KTLC D E+ +
Sbjct: 693 EKEG----EGHSYFSSTKTLCVIDPENRD 717
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 981 bits (2535), Expect = 0.0
Identities = 496/629 (78%), Positives = 548/629 (87%), Gaps = 8/629 (1%)
Query: 16 CFDVDNGTSAGRSPLDPMTSPGSGLILQANFV-HSQRRESFLYRSDSDYDLSPKSMSRNS 74
CFDV+NG S GRSPLDP S +GL+L A F HSQRRESFLYRSDSDYDLSPK+MSRNS
Sbjct: 79 CFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNS 138
Query: 75 SIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITE 134
S+ S+ HGDDLIVTPFAQVLASLR+VRNNF LTNL + +KRSP +QP +++ E
Sbjct: 139 SLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTS-NKRSPAASQPPVSRVNPQE 197
Query: 135 EAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 194
E+YQKLA ETLEELDWCLDQLET+QT SVSEMASNKFKRMLNRELTHLSEMSRSGNQVS
Sbjct: 198 ESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 257
Query: 195 EFISNTFLDKQHEVEIPSPTQKEKEKKKRP--MSQISGVKKLMHSSSLTNSSIPRFGVKT 252
E+ISNTFLDKQ++VEIPSPTQK++EKKK+ M+QISGVKKLMHSSSL N+SI RFGV T
Sbjct: 258 EYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNT 317
Query: 253 EQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYL 312
E ED LAKELED+NKWGL++F +A S NRPLT IM+ IFQERDLLKTF+I DT ITY+
Sbjct: 318 ENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYM 377
Query: 313 MTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPG 372
MTLEDHYH+DVAYHN++HAADV QSTHVLLSTPAL+AVFTDLEILAAIFA+AIHDVDHPG
Sbjct: 378 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPG 437
Query: 373 VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVID 432
VSNQFLINTNSELALMYND SVLENHHLAVGFKLLQEE+CDIF NLTKKQRQ+LRKMVID
Sbjct: 438 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVID 497
Query: 433 IVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL 492
+VLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVL+NMVHCADLSNPTK L
Sbjct: 498 MVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSL 557
Query: 493 QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWAD 552
+LYRQWTDRIMEEFF+QGD+ERERGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWAD
Sbjct: 558 ELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 617
Query: 553 LVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDT 612
LV PDAQDILDTLEDNR WYQS IPQSPSP D+ QG EKFQFELTL+E+
Sbjct: 618 LVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGP 677
Query: 613 EKDSGSQVEEDTSCSDSKTLCTQDSESTE 641
EK+ E + S +KTLC D E+ +
Sbjct: 678 EKEG----EGHSYFSSTKTLCVIDPENRD 702
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 981 bits (2535), Expect = 0.0
Identities = 496/629 (78%), Positives = 548/629 (87%), Gaps = 8/629 (1%)
Query: 16 CFDVDNGTSAGRSPLDPMTSPGSGLILQANFV-HSQRRESFLYRSDSDYDLSPKSMSRNS 74
CFDV+NG S GRSPLDP S +GL+L A F HSQRRESFLYRSDSDYDLSPK+MSRNS
Sbjct: 94 CFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNS 153
Query: 75 SIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITE 134
S+ S+ HGDDLIVTPFAQVLASLR+VRNNF LTNL + +KRSP +QP +++ E
Sbjct: 154 SLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTS-NKRSPAASQPPVSRVNPQE 212
Query: 135 EAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 194
E+YQKLA ETLEELDWCLDQLET+QT SVSEMASNKFKRMLNRELTHLSEMSRSGNQVS
Sbjct: 213 ESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 272
Query: 195 EFISNTFLDKQHEVEIPSPTQKEKEKKKRP--MSQISGVKKLMHSSSLTNSSIPRFGVKT 252
E+ISNTFLDKQ++VEIPSPTQK++EKKK+ M+QISGVKKLMHSSSL N+SI RFGV T
Sbjct: 273 EYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNT 332
Query: 253 EQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYL 312
E ED LAKELED+NKWGL++F +A S NRPLT IM+ IFQERDLLKTF+I DT ITY+
Sbjct: 333 ENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYM 392
Query: 313 MTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPG 372
MTLEDHYH+DVAYHN++HAADV QSTHVLLSTPAL+AVFTDLEILAAIFA+AIHDVDHPG
Sbjct: 393 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPG 452
Query: 373 VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVID 432
VSNQFLINTNSELALMYND SVLENHHLAVGFKLLQEE+CDIF NLTKKQRQ+LRKMVID
Sbjct: 453 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVID 512
Query: 433 IVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL 492
+VLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVL+NMVHCADLSNPTK L
Sbjct: 513 MVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSL 572
Query: 493 QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWAD 552
+LYRQWTDRIMEEFF+QGD+ERERGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWAD
Sbjct: 573 ELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 632
Query: 553 LVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDT 612
LV PDAQDILDTLEDNR WYQS IPQSPSP D+ QG EKFQFELTL+E+
Sbjct: 633 LVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGP 692
Query: 613 EKDSGSQVEEDTSCSDSKTLCTQDSESTE 641
EK+ E + S +KTLC D E+ +
Sbjct: 693 EKEG----EGHSYFSSTKTLCVIDPENRD 717
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 931 bits (2405), Expect = 0.0
Identities = 484/684 (70%), Positives = 562/684 (82%), Gaps = 41/684 (5%)
Query: 4 VNNFPF-----RRHS---WICFDVDNGT--SAGRSPLDPMTSPGSGLILQANFVHSQRRE 53
+ +FPF RRH + F+ +NG S GRSPLD SPG L+L A SQRRE
Sbjct: 26 LTHFPFSDEDTRRHPPGRSVSFEAENGPTPSPGRSPLDSQASPG--LVLHAGAATSQRRE 83
Query: 54 SFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDR 113
SFLYRSDSDYD+SPK+MSRNSS+ S+ H +DLIVTPFAQVLASLR+VR+NF+ LTN+
Sbjct: 84 SFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP-- 141
Query: 114 APS-KRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKF 172
PS KRSP+ + KAT++EE Q+LA ETLEELDWCL+QLET+QT SVSEMAS+KF
Sbjct: 142 VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKF 201
Query: 173 KRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKK---------- 222
KRMLNRELTHLSEMSRSGNQVSE+IS TFLDKQ+EVEIPSPT KE+EK++
Sbjct: 202 KRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPP 261
Query: 223 -------RPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRI 275
+PMSQI+G+KKLMHS+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++F +
Sbjct: 262 PPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCV 321
Query: 276 AELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVV 335
++ +G R LT IM+ IFQERDLLK F+IPVDT++TY++TLEDHYHADVAYHN++HAADV+
Sbjct: 322 SDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVL 381
Query: 336 QSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVL 395
QSTHVLL+TPAL+AVFTDLEILAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVL
Sbjct: 382 QSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVL 441
Query: 396 ENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVET 455
ENHHLAVGFKLLQE+NCDIFQNL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTMVET
Sbjct: 442 ENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVET 501
Query: 456 KKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERE 515
KKVTSSGVLLLDNYSDRIQVL+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDRERE
Sbjct: 502 KKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERE 561
Query: 516 RGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQST 575
RGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY S
Sbjct: 562 RGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSA 621
Query: 576 IPQSPSPAPDDPEE--GRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLC 633
I QSPSP P++ G +KFQFELTLEE+ E E+ S +Q+ C+ + L
Sbjct: 622 IRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEE---EEISMAQI----PCTAQEALT 674
Query: 634 TQDSESTEIPLDEQVEEEAVGEEE 657
Q E LD + EA +E
Sbjct: 675 AQGLSGVEEALDATIAWEASPAQE 698
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 928 bits (2398), Expect = 0.0
Identities = 478/663 (72%), Positives = 553/663 (83%), Gaps = 33/663 (4%)
Query: 17 FDVDNGT--SAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNS 74
F+ +NG S GRSPLD SPG L+L A SQRRESFLYRSDSDYD+SPK+MSRNS
Sbjct: 82 FEAENGPTPSPGRSPLDSQASPG--LVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNS 139
Query: 75 SIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPS-KRSPMCNQPSINKATIT 133
S+ S+ H +DLIVTPFAQVLASLR+VR+NF+ LTN+ PS KRSP+ + KAT++
Sbjct: 140 SVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP--VPSNKRSPLGGPTPVCKATLS 197
Query: 134 EEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQV 193
EE Q+LA ETLEELDWCL+QLET+QT SVSEMAS+KFKRMLNRELTHLSEMSRSGNQV
Sbjct: 198 EETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQV 257
Query: 194 SEFISNTFLDKQHEVEIPSPTQKEKEKKK-----------------RPMSQISGVKKLMH 236
SE+IS TFLDKQ+EVEIPSPT KE+EK++ +PMSQI+G+KKLMH
Sbjct: 258 SEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMH 317
Query: 237 SSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERD 296
S+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++F +++ +G R LT IM+ IFQERD
Sbjct: 318 SNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERD 377
Query: 297 LLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEI 356
LLK F+IPVDT++TY++TLEDHYHADVAYHN++HAADV+QSTHVLL+TPAL+AVFTDLEI
Sbjct: 378 LLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEI 437
Query: 357 LAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQ 416
LAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQE+NCDIFQ
Sbjct: 438 LAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQ 497
Query: 417 NLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 476
NL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTMVETKKVTSSGVLLLDNYSDRIQVL
Sbjct: 498 NLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 557
Query: 477 QNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQV 536
+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDRERERGMEISPMCDKH ASVEKSQV
Sbjct: 558 RNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQV 617
Query: 537 GFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEE--GRQGQ 594
GFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY S I QSPSP P++ G
Sbjct: 618 GFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPL 677
Query: 595 TEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVG 654
+KFQFELTLEE+ E E+ S +Q+ C+ + L Q E LD + EA
Sbjct: 678 PDKFQFELTLEEEEE---EEISMAQI----PCTAQEALTAQGLSGVEEALDATIAWEASP 730
Query: 655 EEE 657
+E
Sbjct: 731 AQE 733
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 928 bits (2398), Expect = 0.0
Identities = 478/663 (72%), Positives = 553/663 (83%), Gaps = 33/663 (4%)
Query: 17 FDVDNGT--SAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNS 74
F+ +NG S GRSPLD SPG L+L A SQRRESFLYRSDSDYD+SPK+MSRNS
Sbjct: 108 FEAENGPTPSPGRSPLDSQASPG--LVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNS 165
Query: 75 SIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPS-KRSPMCNQPSINKATIT 133
S+ S+ H +DLIVTPFAQVLASLR+VR+NF+ LTN+ PS KRSP+ + KAT++
Sbjct: 166 SVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP--VPSNKRSPLGGPTPVCKATLS 223
Query: 134 EEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQV 193
EE Q+LA ETLEELDWCL+QLET+QT SVSEMAS+KFKRMLNRELTHLSEMSRSGNQV
Sbjct: 224 EETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQV 283
Query: 194 SEFISNTFLDKQHEVEIPSPTQKEKEKKK-----------------RPMSQISGVKKLMH 236
SE+IS TFLDKQ+EVEIPSPT KE+EK++ +PMSQI+G+KKLMH
Sbjct: 284 SEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMH 343
Query: 237 SSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERD 296
S+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++F +++ +G R LT IM+ IFQERD
Sbjct: 344 SNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERD 403
Query: 297 LLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEI 356
LLK F+IPVDT++TY++TLEDHYHADVAYHN++HAADV+QSTHVLL+TPAL+AVFTDLEI
Sbjct: 404 LLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEI 463
Query: 357 LAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQ 416
LAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQE+NCDIFQ
Sbjct: 464 LAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQ 523
Query: 417 NLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 476
NL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTMVETKKVTSSGVLLLDNYSDRIQVL
Sbjct: 524 NLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 583
Query: 477 QNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQV 536
+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDRERERGMEISPMCDKH ASVEKSQV
Sbjct: 584 RNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQV 643
Query: 537 GFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEE--GRQGQ 594
GFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY S I QSPSP P++ G
Sbjct: 644 GFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPL 703
Query: 595 TEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVG 654
+KFQFELTLEE+ E E+ S +Q+ C+ + L Q E LD + EA
Sbjct: 704 PDKFQFELTLEEEEE---EEISMAQI----PCTAQEALTAQGLSGVEEALDATIAWEASP 756
Query: 655 EEE 657
+E
Sbjct: 757 AQE 759
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 922 bits (2383), Expect = 0.0
Identities = 466/638 (73%), Positives = 536/638 (84%), Gaps = 12/638 (1%)
Query: 15 ICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNS 74
+CFD++NG S GR LDP +SPG G I+QA HSQRRESFLYRSDSDY+LSPK+MSRNS
Sbjct: 48 LCFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNS 107
Query: 75 SIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITE 134
S+ASD+HG+D+IVTPFAQVLASLRTVR+N AAL Q +K+ P+ N S N+ E
Sbjct: 108 SVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAE 167
Query: 135 EAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 194
+ QKLA ETL+ELDWCLDQLETLQTRHSV EMASNKFKR+LNRELTHLSE SRSGNQVS
Sbjct: 168 DTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVS 227
Query: 195 EFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQ 254
E+IS TFLD+Q EVE+P T +E + PMS+ISG+ L HS+SL+++++PRFGV+T+Q
Sbjct: 228 EYISRTFLDQQTEVELPKVTAEEAPQ---PMSRISGLHGLCHSASLSSATVPRFGVQTDQ 284
Query: 255 EDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMT 314
E+ LAKELED NKWGL VF++AELSGNRPLT I+ +IFQERDLLKTF+IP DTL TYL+
Sbjct: 285 EEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLM 344
Query: 315 LEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVS 374
LE HYHA+VAYHN++HAADV QSTHVLL+TPALEAVFTDLEILAA+FASAIHDVDHPGVS
Sbjct: 345 LEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVS 404
Query: 375 NQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIV 434
NQFLINTNSELALMYND+SVLENHHLAVGFKLLQ ENCDIFQNL+ KQR SLR+MVID+V
Sbjct: 405 NQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMV 464
Query: 435 LATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL 494
LATDMSKHMNLLADLKTMVETKKVTS GVLLLDNYSDRIQVLQN+VHCADLSNPTKPL L
Sbjct: 465 LATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPL 524
Query: 495 YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLV 554
YRQWTDRIM EFF+QGDRERE G++ISPMCDKH ASVEKSQVGFIDYI HPLWETWADLV
Sbjct: 525 YRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLV 584
Query: 555 HPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEK 614
HPDAQD+LDTLEDNREWYQS IP+SPS + +G ++FQFELTLEE E D E+
Sbjct: 585 HPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG----PDRFQFELTLEEAEEEDEEE 640
Query: 615 DSGSQ----VEEDTSCSDSKTLCTQ-DSESTEIPLDEQ 647
+ + +E D++ L + + ++PLD Q
Sbjct: 641 EEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQ 678
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 918 bits (2372), Expect = 0.0
Identities = 465/636 (73%), Positives = 534/636 (83%), Gaps = 12/636 (1%)
Query: 17 FDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSI 76
FD++NG S GR LDP +SPG G I+QA HSQRRESFLYRSDSDY+LSPK+MSRNSS+
Sbjct: 82 FDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSV 141
Query: 77 ASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEA 136
ASD+HG+D+IVTPFAQVLASLRTVR+N AAL Q +K+ P+ N S N+ E+
Sbjct: 142 ASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDT 201
Query: 137 YQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEF 196
QKLA ETL+ELDWCLDQLETLQTRHSV EMASNKFKR+LNRELTHLSE SRSGNQVSE+
Sbjct: 202 GQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEY 261
Query: 197 ISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQED 256
IS TFLD+Q EVE+P T +E + PMS+ISG+ L HS+SL+++++PRFGV+T+QE+
Sbjct: 262 ISRTFLDQQTEVELPKVTAEEAPQ---PMSRISGLHGLCHSASLSSATVPRFGVQTDQEE 318
Query: 257 VLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLE 316
LAKELED NKWGL VF++AELSGNRPLT I+ +IFQERDLLKTF+IP DTL TYL+ LE
Sbjct: 319 QLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLE 378
Query: 317 DHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQ 376
HYHA+VAYHN++HAADV QSTHVLL+TPALEAVFTDLEILAA+FASAIHDVDHPGVSNQ
Sbjct: 379 GHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQ 438
Query: 377 FLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLA 436
FLINTNSELALMYND+SVLENHHLAVGFKLLQ ENCDIFQNL+ KQR SLR+MVID+VLA
Sbjct: 439 FLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLA 498
Query: 437 TDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYR 496
TDMSKHMNLLADLKTMVETKKVTS GVLLLDNYSDRIQVLQN+VHCADLSNPTKPL LYR
Sbjct: 499 TDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYR 558
Query: 497 QWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHP 556
QWTDRIM EFF+QGDRERE G++ISPMCDKH ASVEKSQVGFIDYI HPLWETWADLVHP
Sbjct: 559 QWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHP 618
Query: 557 DAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDS 616
DAQD+LDTLEDNREWYQS IP+SPS + +G ++FQFELTLEE E D E++
Sbjct: 619 DAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG----PDRFQFELTLEEAEEEDEEEEE 674
Query: 617 GSQ----VEEDTSCSDSKTLCTQ-DSESTEIPLDEQ 647
+ +E D++ L + + ++PLD Q
Sbjct: 675 EGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQ 710
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 887 bits (2292), Expect = 0.0
Identities = 450/611 (73%), Positives = 516/611 (84%), Gaps = 12/611 (1%)
Query: 42 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR 101
+QA HSQRRESFLYRSDSDY+LSPK+MSRNSS+ASD+HG+D+IVTPFAQVLASLRTVR
Sbjct: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
Query: 102 NNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTR 161
+N AAL Q +K+ P+ N S N+ E+ QKLA ETL+ELDWCLDQLETLQTR
Sbjct: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
Query: 162 HSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKK 221
HSV EMASNKFKR+LNRELTHLSE SRSGNQVSE+IS TFLD+Q EVE+P T +E +
Sbjct: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQ- 179
Query: 222 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGN 281
PMS+ISG+ L HS+SL+++++PRFGV+T+QE+ LAKELED NKWGL VF++AELSGN
Sbjct: 180 --PMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGN 237
Query: 282 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVL 341
RPLT I+ +IFQERDLLKTF+IP DTL TYL+ LE HYHA+VAYHN++HAADV QSTHVL
Sbjct: 238 RPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVL 297
Query: 342 LSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA 401
L+TPALEAVFTDLEILAA+FASAIHDVDHPGVSNQFLINTNSELALMYND+SVLENHHLA
Sbjct: 298 LATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLA 357
Query: 402 VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS 461
VGFKLLQ ENCDIFQNL+ KQR SLR+MVID+VLATDMSKHMNLLADLKTMVETKKVTS
Sbjct: 358 VGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSL 417
Query: 462 GVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEIS 521
GVLLLDNYSDRIQVLQN+VHCADLSNPTKPL LYRQWTDRIM EFF+QGDRERE G++IS
Sbjct: 418 GVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDIS 477
Query: 522 PMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPS 581
PMCDKH ASVEKSQVGFIDYI HPLWETWADLVHPDAQD+LDTLEDNREWYQS IP+SPS
Sbjct: 478 PMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS 537
Query: 582 PAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQ----VEEDTSCSDSKTLCTQ-D 636
+ +G ++FQFELTLEE E D E++ + +E D++ L +
Sbjct: 538 DLTNPERDG----PDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAG 593
Query: 637 SESTEIPLDEQ 647
+ ++PLD Q
Sbjct: 594 PDPGDLPLDNQ 604
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 828 bits (2138), Expect = 0.0
Identities = 421/539 (78%), Positives = 465/539 (86%), Gaps = 15/539 (2%)
Query: 105 AALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSV 164
+A+ +LQ P+ P+C EE+YQKLA ETLEELDWCLDQLET+QT SV
Sbjct: 20 SAMDSLQPLQPNYM-PVC--------LFAEESYQKLAMETLEELDWCLDQLETIQTYRSV 70
Query: 165 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP 224
SEMASNKFKRMLNRELTHLSEMSRSGNQVSE+ISNTFLDKQ++VEIPSPTQK++EKKK+
Sbjct: 71 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ 130
Query: 225 --MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNR 282
M+QISGVKKLMHSSSL N+SI RFGV TE ED LAKELED+NKWGL++F +A S NR
Sbjct: 131 QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR 190
Query: 283 PLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL 342
PLT IM+ IFQERDLLKTF+I DT ITY+MTLEDHYH+DVAYHN++HAADV QSTHVLL
Sbjct: 191 PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL 250
Query: 343 STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAV 402
STPAL+AVFTDLEILAAIFA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAV
Sbjct: 251 STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV 310
Query: 403 GFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSG 462
GFKLLQEE+CDIF NLTKKQRQ+LRKMVID+VLATDMSKHM+LLADLKTMVETKKVTSSG
Sbjct: 311 GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG 370
Query: 463 VLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISP 522
VLLLDNY+DRIQVL+NMVHCADLSNPTK L+LYRQWTDRIMEEFF+QGD+ERERGMEISP
Sbjct: 371 VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP 430
Query: 523 MCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSP 582
MCDKH ASVEKSQVGFIDYIVHPLWETWADLV PDAQDILDTLEDNR WYQS IPQSPSP
Sbjct: 431 MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP 490
Query: 583 APDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTE 641
D+ QG EKFQFELTL+E+ EK+ E + S +KTLC D E+ +
Sbjct: 491 PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEG----EGHSYFSSTKTLCVIDPENRD 545
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 744 bits (1921), Expect = 0.0
Identities = 375/507 (73%), Positives = 432/507 (85%), Gaps = 26/507 (5%)
Query: 170 NKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKK------- 222
++FKRMLNRELTHLSEMSRSGNQVSE+IS TFLDKQ+EVEIPSPT KE+EK++
Sbjct: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
Query: 223 ----------RPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHV 272
+PMSQI+G+KKLMHS+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++
Sbjct: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
Query: 273 FRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAA 332
F +++ +G R LT IM+ IFQERDLLK F+IPVDT++TY++TLEDHYHADVAYHN++HAA
Sbjct: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
Query: 333 DVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS 392
DV+QSTHVLL+TPAL+AVFTDLEILAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND
Sbjct: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
Query: 393 SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTM 452
SVLENHHLAVGFKLLQE+NCDIFQNL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTM
Sbjct: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
Query: 453 VETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDR 512
VETKKVTSSGVLLLDNYSDRIQVL+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDR
Sbjct: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
Query: 513 ERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWY 572
ERERGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY
Sbjct: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
Query: 573 QSTIPQSPSPAPDDPEE--GRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSK 630
S I QSPSP P++ G +KFQFELTLEE+ E E+ S +Q+ C+ +
Sbjct: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEE---EEISMAQI----PCTAQE 493
Query: 631 TLCTQDSESTEIPLDEQVEEEAVGEEE 657
L Q E LD + EA +E
Sbjct: 494 ALTAQGLSGVEEALDATIAWEASPAQE 520
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 247 bits (631), Expect = 2e-65
Identities = 139/383 (36%), Positives = 224/383 (58%), Gaps = 23/383 (6%)
Query: 173 KRMLNRELTHLSEMSRSG--NQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISG 230
+R+L+ E LS++ ++V +++++TF K T+K+ E+K + S +
Sbjct: 72 RRLLDTE-DELSDIQTDSVPSEVRDWLASTFTRKM------GMTKKKPEEKPKFRSIVHA 124
Query: 231 VKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT 290
V+ + + + G+ ++ L+DV+KW VF + E SG L +++
Sbjct: 125 VQAGIFVERMYRKTYHMVGLAYPAAVIVT--LKDVDKWSFDVFALNEASGEHSLKFMIYE 182
Query: 291 IFQERDLLKTFKIPVDTLITYLMTLEDHYHA-DVAYHNNIHAADVVQSTHVLLSTPALEA 349
+F DL+ FKIPV LIT+ LE Y YHN IHAADV Q+ H ++ +
Sbjct: 183 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 242
Query: 350 VFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQE 409
T+LEILA +FA+AIHD +H G +N F I T S++A++YND SVLENHH++ ++L+QE
Sbjct: 243 WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQE 302
Query: 410 ENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNY 469
E +I NL+K + LR +VI++VL+TDMS H + +++ ++ + G+
Sbjct: 303 EEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI------ 352
Query: 470 SDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNA 529
DR + + ++H AD+S+P K +L+ +WT +MEEFF QGD+E E G+ SP+CD+ +
Sbjct: 353 -DRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKST 411
Query: 530 SVEKSQVGFIDYIVHPLWETWAD 552
V +SQ+GFID+IV P + D
Sbjct: 412 MVAQSQIGFIDFIVEPTFSLLTD 434
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 247 bits (631), Expect = 2e-65
Identities = 139/383 (36%), Positives = 224/383 (58%), Gaps = 23/383 (6%)
Query: 173 KRMLNRELTHLSEMSRSG--NQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISG 230
+R+L+ E LS++ ++V +++++TF K T+K+ E+K + S +
Sbjct: 72 RRLLDTE-DELSDIQTDSVPSEVRDWLASTFTRKM------GMTKKKPEEKPKFRSIVHA 124
Query: 231 VKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT 290
V+ + + + G+ ++ L+DV+KW VF + E SG L +++
Sbjct: 125 VQAGIFVERMYRKTYHMVGLAYPAAVIVT--LKDVDKWSFDVFALNEASGEHSLKFMIYE 182
Query: 291 IFQERDLLKTFKIPVDTLITYLMTLEDHYHA-DVAYHNNIHAADVVQSTHVLLSTPALEA 349
+F DL+ FKIPV LIT+ LE Y YHN IHAADV Q+ H ++ +
Sbjct: 183 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 242
Query: 350 VFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQE 409
T+LEILA +FA+AIHD +H G +N F I T S++A++YND SVLENHH++ ++L+QE
Sbjct: 243 WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQE 302
Query: 410 ENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNY 469
E +I NL+K + LR +VI++VL+TDMS H + +++ ++ + G+
Sbjct: 303 EEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI------ 352
Query: 470 SDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNA 529
DR + + ++H AD+S+P K +L+ +WT +MEEFF QGD+E E G+ SP+CD+ +
Sbjct: 353 -DRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKST 411
Query: 530 SVEKSQVGFIDYIVHPLWETWAD 552
V +SQ+GFID+IV P + D
Sbjct: 412 MVAQSQIGFIDFIVEPTFSLLTD 434
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 239 bits (611), Expect = 5e-63
Identities = 142/415 (34%), Positives = 219/415 (52%), Gaps = 29/415 (6%)
Query: 262 LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHA 321
L+DV+KW VF + E SG+ L I + + DL+ FKIP+ L++++ LE Y
Sbjct: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
Query: 322 DV-AYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN 380
YHN +HAADV Q+ H LL + T+LEI A IF++AIHD +H G +N F I
Sbjct: 223 HKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQ 282
Query: 381 TNSELALMYNDSSVLENHHLAVGFKLLQ-EENCDIFQNLTKKQRQSLRKMVIDIVLATDM 439
T S+ A++YND SVLENHHL+ ++LLQ +E +I NL+K + R +VI++V+ATDM
Sbjct: 283 TRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDM 342
Query: 440 SKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWT 499
S H + +KT ++ + ++ + L M+H AD+S+P K L+ +WT
Sbjct: 343 SCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHRWT 391
Query: 500 DRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQ 559
++EEFFRQGDRE E G+ SP+CD+ + V +SQVGFID+IV P + D+
Sbjct: 392 MSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVS 451
Query: 560 DILDTLED-----NREWYQSTIPQSPSPAPDDPEEGRQG---------QTEKFQFELTLE 605
++D R ++I S + G +G + F+ T
Sbjct: 452 PLIDETSQTGGTGQRRSSLNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWT 511
Query: 606 EDGESDTEKDSGSQVEEDTSC--SDSKTLCTQDSESTEIPLDEQVEEEAVGEEEE 658
E + E+ +E+ + ++ K + + E+ Q EE A G+ E+
Sbjct: 512 EVVHINRERWRAKVPKEEKAKKEAEEKARLAAEEQQKEMEAKSQAEEGASGKAEK 566
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 234 bits (596), Expect = 3e-61
Identities = 127/333 (38%), Positives = 196/333 (58%), Gaps = 22/333 (6%)
Query: 262 LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHA 321
L++++ W VF + + + + L I+ + +L+ FKIP L+++L LE Y
Sbjct: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
Query: 322 -DVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN 380
YHN IHAADV Q+ H L + +++E+LA IFA+AIHD +H G +N F I
Sbjct: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
Query: 381 TNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS 440
T SE A++YND SVLENHH++ F+L+Q++ +IF NLTK + LR +VI++VLATDMS
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
Query: 441 KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTD 500
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
Query: 501 RIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQD 560
+MEEFFRQGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D+ Q
Sbjct: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
Query: 561 ILDTLEDNR-------EWYQSTIP-QSPSPAPD 585
+ D ED++ +W Q ++ + P PD
Sbjct: 447 LAD--EDSKSKNQPSFQWRQPSLDVEVGDPNPD 477
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 228 bits (582), Expect = 1e-59
Identities = 128/400 (32%), Positives = 215/400 (53%), Gaps = 27/400 (6%)
Query: 222 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKE---LEDVNKWGLHVFRIAEL 278
K+ + ++ ++ H+S L IP+ + ED L + L V W +F L
Sbjct: 66 KKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRL 125
Query: 279 SGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQST 338
+ L ++ +F L+ FK+ + TL +L+ +++ YH+ YHN +HAADV Q+
Sbjct: 126 TNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAM 185
Query: 339 HVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENH 398
H L P L + T L+I+ + A+A HDVDHPGV+ FLI TN LA +Y + SVLENH
Sbjct: 186 HCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENH 245
Query: 399 HLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKV 458
H +L+E + +L K+ Q + + + ++LATD+++ L LK + K
Sbjct: 246 HWRSTIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD- 302
Query: 459 TSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGM 518
L L++ DR +LQ + CAD+ NP + ++ +QW++R+ EEF+RQG+ E++ +
Sbjct: 303 -----LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFEL 357
Query: 519 EISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPD--AQDILDTLEDNREWYQSTI 576
EISP+C++ S+ Q+GF+ YIV PL+ WA ++++L L N+ ++S +
Sbjct: 358 EISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLL 417
Query: 577 PQ------SPSPAPDDPEEGRQGQTEKFQFELTLEEDGES 610
P+ S PD G+ ++E E++G+S
Sbjct: 418 PRQHRSRGSSGSGPDHDHAGQGTESE--------EQEGDS 449
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 218 bits (555), Expect = 1e-56
Identities = 113/329 (34%), Positives = 194/329 (58%), Gaps = 15/329 (4%)
Query: 258 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 317
+A+ +E+ W +F + + NRPL + +F + + TL ++L +E
Sbjct: 442 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 501
Query: 318 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 377
+YH+ YHN+ H+ADV+ +T LS ++ ++ +AA+ A+ IHDVDHPG +N F
Sbjct: 502 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 561
Query: 378 LINTNSELALMYNDSSVLENHHLAVGFKLLQ-EENCDIFQNLTKKQRQSLRKMVIDIVLA 436
L N SELA++YND++VLE+HH A+ F+L ++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 562 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 621
Query: 437 TDMSKHM-----------NLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADL 485
T+M+KH LA L+ ET K +L +R + + ++ CAD+
Sbjct: 622 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 681
Query: 486 SNPTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVH 544
SNP +PLQ +W RI EE+F Q D E+++G+ + P+ D++ S+ KSQ+ FIDY +
Sbjct: 682 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 741
Query: 545 PLWETWADLVHPDAQDILDTLEDNREWYQ 573
+++ W V D D++ L++N ++++
Sbjct: 742 DMFDAWDAFV--DLPDLMQHLDNNFKYWK 768
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 218 bits (555), Expect = 1e-56
Identities = 113/329 (34%), Positives = 194/329 (58%), Gaps = 15/329 (4%)
Query: 258 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 317
+A+ +E+ W +F + + NRPL + +F + + TL ++L +E
Sbjct: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
Query: 318 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 377
+YH+ YHN+ H+ADV+ +T LS ++ ++ +AA+ A+ IHDVDHPG +N F
Sbjct: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
Query: 378 LINTNSELALMYNDSSVLENHHLAVGFKLLQ-EENCDIFQNLTKKQRQSLRKMVIDIVLA 436
L N SELA++YND++VLE+HH A+ F+L ++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
Query: 437 TDMSKHM-----------NLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADL 485
T+M+KH LA L+ ET K +L +R + + ++ CAD+
Sbjct: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
Query: 486 SNPTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVH 544
SNP +PLQ +W RI EE+F Q D E+++G+ + P+ D++ S+ KSQ+ FIDY +
Sbjct: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
Query: 545 PLWETWADLVHPDAQDILDTLEDNREWYQ 573
+++ W V D D++ L++N ++++
Sbjct: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWK 814
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 208 bits (529), Expect = 1e-53
Identities = 109/326 (33%), Positives = 191/326 (58%), Gaps = 16/326 (4%)
Query: 258 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 317
+++ L++ W ++F + ++ RPL + +F + + TL + +E
Sbjct: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
Query: 318 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 377
+YH+ AYHN+ HAADV+ +T L ++ L+ +AA+ A+ +HDVDHPG +N F
Sbjct: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
Query: 378 LINTNSELALMYNDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLA 436
L N SELA++YND++VLE+HH A+ F+L +++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
Query: 437 TDMSKHMNLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLQNMVHCADLSN 487
T+M+KH + K + K ++ + D N+ ++I + + M+ CAD++N
Sbjct: 680 TEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVAN 737
Query: 488 PTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVHPL 546
P +PL L +W RI EE+F Q D E+ +G+ + P+ D++ S+ KSQ+ FIDY + +
Sbjct: 738 PCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDM 797
Query: 547 WETWADLVHPDAQDILDTLEDN-REW 571
++ W H A ++ L DN + W
Sbjct: 798 FDAWDAFAHLPA--LMQHLADNYKHW 821
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 208 bits (529), Expect = 1e-53
Identities = 109/326 (33%), Positives = 191/326 (58%), Gaps = 16/326 (4%)
Query: 258 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 317
+++ L++ W ++F + ++ RPL + +F + + TL + +E
Sbjct: 527 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 586
Query: 318 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 377
+YH+ AYHN+ HAADV+ +T L ++ L+ +AA+ A+ +HDVDHPG +N F
Sbjct: 587 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 646
Query: 378 LINTNSELALMYNDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLA 436
L N SELA++YND++VLE+HH A+ F+L +++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 647 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 706
Query: 437 TDMSKHMNLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLQNMVHCADLSN 487
T+M+KH + K + K ++ + D N+ ++I + + M+ CAD++N
Sbjct: 707 TEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVAN 764
Query: 488 PTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVHPL 546
P +PL L +W RI EE+F Q D E+ +G+ + P+ D++ S+ KSQ+ FIDY + +
Sbjct: 765 PCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDM 824
Query: 547 WETWADLVHPDAQDILDTLEDN-REW 571
++ W H A ++ L DN + W
Sbjct: 825 FDAWDAFAHLPA--LMQHLADNYKHW 848
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 208 bits (529), Expect = 1e-53
Identities = 109/326 (33%), Positives = 191/326 (58%), Gaps = 16/326 (4%)
Query: 258 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 317
+++ L++ W ++F + ++ RPL + +F + + TL + +E
Sbjct: 492 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 551
Query: 318 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 377
+YH+ AYHN+ HAADV+ +T L ++ L+ +AA+ A+ +HDVDHPG +N F
Sbjct: 552 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 611
Query: 378 LINTNSELALMYNDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLA 436
L N SELA++YND++VLE+HH A+ F+L +++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 612 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 671
Query: 437 TDMSKHMNLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLQNMVHCADLSN 487
T+M+KH + K + K ++ + D N+ ++I + + M+ CAD++N
Sbjct: 672 TEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVAN 729
Query: 488 PTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVHPL 546
P +PL L +W RI EE+F Q D E+ +G+ + P+ D++ S+ KSQ+ FIDY + +
Sbjct: 730 PCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDM 789
Query: 547 WETWADLVHPDAQDILDTLEDN-REW 571
++ W H A ++ L DN + W
Sbjct: 790 FDAWDAFAHLPA--LMQHLADNYKHW 813
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 208 bits (529), Expect = 1e-53
Identities = 109/326 (33%), Positives = 191/326 (58%), Gaps = 16/326 (4%)
Query: 258 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 317
+++ L++ W ++F + ++ RPL + +F + + TL + +E
Sbjct: 450 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 509
Query: 318 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 377
+YH+ AYHN+ HAADV+ +T L ++ L+ +AA+ A+ +HDVDHPG +N F
Sbjct: 510 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 569
Query: 378 LINTNSELALMYNDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLA 436
L N SELA++YND++VLE+HH A+ F+L +++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 570 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 629
Query: 437 TDMSKHMNLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLQNMVHCADLSN 487
T+M+KH + K + K ++ + D N+ ++I + + M+ CAD++N
Sbjct: 630 TEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVAN 687
Query: 488 PTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVHPL 546
P +PL L +W RI EE+F Q D E+ +G+ + P+ D++ S+ KSQ+ FIDY + +
Sbjct: 688 PCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDM 747
Query: 547 WETWADLVHPDAQDILDTLEDN-REW 571
++ W H A ++ L DN + W
Sbjct: 748 FDAWDAFAHLPA--LMQHLADNYKHW 771
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 208 bits (529), Expect = 1e-53
Identities = 109/326 (33%), Positives = 191/326 (58%), Gaps = 16/326 (4%)
Query: 258 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 317
+++ L++ W ++F + ++ RPL + +F + + TL + +E
Sbjct: 547 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 606
Query: 318 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 377
+YH+ AYHN+ HAADV+ +T L ++ L+ +AA+ A+ +HDVDHPG +N F
Sbjct: 607 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 666
Query: 378 LINTNSELALMYNDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLA 436
L N SELA++YND++VLE+HH A+ F+L +++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 667 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 726
Query: 437 TDMSKHMNLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLQNMVHCADLSN 487
T+M+KH + K + K ++ + D N+ ++I + + M+ CAD++N
Sbjct: 727 TEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVAN 784
Query: 488 PTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVHPL 546
P +PL L +W RI EE+F Q D E+ +G+ + P+ D++ S+ KSQ+ FIDY + +
Sbjct: 785 PCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDM 844
Query: 547 WETWADLVHPDAQDILDTLEDN-REW 571
++ W H A ++ L DN + W
Sbjct: 845 FDAWDAFAHLPA--LMQHLADNYKHW 868
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 208 bits (529), Expect = 1e-53
Identities = 126/411 (30%), Positives = 215/411 (52%), Gaps = 19/411 (4%)
Query: 148 LDWCLDQLE----TLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLD 203
L WCL + T + R ++S +S++ + R L + SR+G + S+ ++D
Sbjct: 5 LIWCLALVLIKWITSKRRGAISYDSSDQTALYI-RMLGDVRVRSRAGFESERRGSHPYID 63
Query: 204 KQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKE-- 261
+ S ++ E R + ++ ++ + SS + + +D +
Sbjct: 64 FRI---FHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC 120
Query: 262 -LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYH 320
LE V W +F L+ L + +F L++ F + + L +L+ +++ YH
Sbjct: 121 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 180
Query: 321 ADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN 380
+ YHN +HAADV Q+ H L P L T +IL ++ A+A HD+DHPGV+ FLI
Sbjct: 181 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
Query: 381 TNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS 440
TN LA +Y ++SVLENHH LL+E +F +L + RQ + + ++LATD+S
Sbjct: 241 TNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDIS 298
Query: 441 KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTD 500
+ L+ ++ ++ G L L++ R VLQ + CAD+ NP + +L +QW++
Sbjct: 299 RQNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSE 352
Query: 501 RIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWA 551
++ EEFF QGD E++ + +SP+CD+H S+ Q+GF+ Y+V PL+ WA
Sbjct: 353 KVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 192 bits (489), Expect = 6e-49
Identities = 117/395 (29%), Positives = 204/395 (51%), Gaps = 15/395 (3%)
Query: 151 CLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEI 210
C + + Q R ++S +S++ + R L + SR+G + S+ ++D +
Sbjct: 38 CPNPRQLSQRRGAISYDSSDQTALYI-RMLGDVRVRSRAGFESERRGSHPYIDFRI---F 93
Query: 211 PSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKE---LEDVNK 267
S ++ E R + ++ ++ + SS + + +D + LE V
Sbjct: 94 HSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGN 153
Query: 268 WGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHN 327
W +F L+ L + +F L++ F + + L +L+ +++ YH+ YHN
Sbjct: 154 WNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHN 213
Query: 328 NIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELAL 387
+HAADV Q+ H L P L T +IL ++ A+A HD+DHPGV+ FLI TN LA
Sbjct: 214 AVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLAT 273
Query: 388 MYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLA 447
+Y ++SVLENHH LL+E +F +L + RQ + + ++LATD+S+ L+
Sbjct: 274 LYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISRQNEYLS 331
Query: 448 DLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFF 507
++ ++ G L L++ R VLQ + CAD+ NP + +L +QW++++ EEFF
Sbjct: 332 LFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFF 385
Query: 508 RQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI 542
QGD E++ + +SP+CD+H S+ Q+G Y+
Sbjct: 386 HQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
>gi|40254434 phosphodiesterase 3B [Homo sapiens]
Length = 1112
Score = 188 bits (477), Expect = 2e-47
Identities = 158/568 (27%), Positives = 254/568 (44%), Gaps = 98/568 (17%)
Query: 159 QTRHSVSEMASNKFKRMLNRELTHLSE-----MSRSGNQVSEFISNTFLDKQHEVEIPSP 213
Q R+S S + ++ +ML T S+ +SG + + F +F K E +
Sbjct: 567 QLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESF--KLMETQQEEE 624
Query: 214 TQKEKEKKKRPMSQISGVKKLMHSSSLTN--SSIPRFGVKTEQEDVLAKELEDVNKWGLH 271
T+K K+ +K + + S TN + + E+ D L +E ++ W
Sbjct: 625 TEK-KDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSL---IEKMSNWNFP 680
Query: 272 VFRIAELSGN---RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNN 328
+F + E G R L+ +M+T+FQ+ LL+ FKIP + Y LE+ Y D+ YHN
Sbjct: 681 IFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYR-DIPYHNR 739
Query: 329 IHAADVVQSTHVLLSTPA------------------------------------------ 346
IHA DV+ + L + P
Sbjct: 740 IHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESY 799
Query: 347 --LEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF 404
L + LE++A A+A+HD DHPG +N FL+ TN+ A++YND SVLENHH A +
Sbjct: 800 GCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAW 859
Query: 405 KL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGV 463
L L + +L + + R +VI+ +LATD+ KH + LA+ + V S+G+
Sbjct: 860 NLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA--KANDVNSNGI 917
Query: 464 LLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPM 523
N +DR+ V Q + AD++ P K L+ +WT+ I+ EF+ QGD E G+ ISP
Sbjct: 918 EW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPF 976
Query: 524 CDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPA 583
D+ + + K Q FI +IV PL ++ DA +L +W ++ +
Sbjct: 977 MDRSSPQLAKLQESFITHIVGPLCNSY------DAAGLLP-----GQWLEA--EEDNDTE 1023
Query: 584 PDDPEEGRQGQTEKFQFELTLEEDGE----------------SDTEKDSGSQVEEDTSC- 626
D E+G + TE + E L ++ K VEE+ C
Sbjct: 1024 SGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCK 1083
Query: 627 SDSKTLCTQDS---ESTEIPLDEQVEEE 651
+D L ++S ++ EI + E+ +EE
Sbjct: 1084 ADGNKLQVENSSLPQADEIQVIEEADEE 1111
>gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens]
Length = 459
Score = 177 bits (450), Expect = 2e-44
Identities = 115/403 (28%), Positives = 207/403 (51%), Gaps = 28/403 (6%)
Query: 184 SEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNS 243
SE + N++ ++N + VE+ E EK K + ++ ++L SS TN
Sbjct: 30 SERAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMR--EELAARSSRTNC 87
Query: 244 SI------------PRFGVKTEQEDVLAKE-LEDVNKWGLHVFRIAELSGNRPLTVIMHT 290
PR V T + +L+ E +E + K F + N L+ + H
Sbjct: 88 PCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRK---PTFDVWLWEPNEMLSCLEH- 143
Query: 291 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 350
++ + L++ F I TL +L + D+Y + +HN H V Q + ++ +L+
Sbjct: 144 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEK 202
Query: 351 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 410
F+ +IL + A+ HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L E
Sbjct: 203 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEP 262
Query: 411 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 470
C+IF N+ + +R+ +I ++LATDM++H ++ K +E ++ + L
Sbjct: 263 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTL---- 318
Query: 471 DRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS 530
+ ++ C D+SN +P+++ W D ++EE+F Q DRE+ G+ ++P D+ +
Sbjct: 319 ----LKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVT 374
Query: 531 VEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 573
+Q+GFI +++ P++ET L + +L L ++R+ Y+
Sbjct: 375 KATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYE 417
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 177 bits (449), Expect = 3e-44
Identities = 98/328 (29%), Positives = 176/328 (53%), Gaps = 20/328 (6%)
Query: 246 PRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPV 305
P++ + E + L K DV W N L+ + H ++ + L++ F I
Sbjct: 37 PKYLLSPETIEALRKPTFDVWLW----------EPNEMLSCLEH-MYHDLGLVRDFSINP 85
Query: 306 DTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAI 365
TL +L + D+Y + +HN H V Q + ++ +L+ F+ +IL + A+
Sbjct: 86 VTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAIC 144
Query: 366 HDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQS 425
HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L E C+IF N+ +
Sbjct: 145 HDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQ 204
Query: 426 LRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADL 485
+R+ +I ++LATDM++H ++ K +E ++ + L + ++ C D+
Sbjct: 205 IRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTL--------LKMILIKCCDI 256
Query: 486 SNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHP 545
SN +P+++ W D ++EE+F Q DRE+ G+ ++P D+ + +Q+GFI +++ P
Sbjct: 257 SNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIP 316
Query: 546 LWETWADLVHPDAQDILDTLEDNREWYQ 573
++ET L + +L L ++R+ Y+
Sbjct: 317 MFETVTKLFPMVEEIMLQPLWESRDRYE 344
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,316,731
Number of Sequences: 37866
Number of extensions: 1167615
Number of successful extensions: 6536
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 125
Number of HSP's successfully gapped in prelim test: 171
Number of HSP's that attempted gapping in prelim test: 5191
Number of HSP's gapped (non-prelim): 905
length of query: 673
length of database: 18,247,518
effective HSP length: 109
effective length of query: 564
effective length of database: 14,120,124
effective search space: 7963749936
effective search space used: 7963749936
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.