Search of human proteins with 32171241

Search of human proteins with 32171241

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
         (736 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]            1476   0.0  
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]            1476   0.0  
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]            1295   0.0  
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]            1057   0.0  
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]             981   0.0  
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]            977   0.0  
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]            939   0.0  
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]            938   0.0  
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]            938   0.0  
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]      856   0.0  
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]      852   0.0  
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]      826   0.0  
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]              736   0.0  
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]             235   1e-61
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]             235   1e-61
gi|4505677 phosphodiesterase 1B [Homo sapiens]                        233   5e-61
gi|4826894 phosphodiesterase 1C [Homo sapiens]                        231   2e-60
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]             226   4e-59
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]             226   4e-59
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]             217   4e-56
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]             217   4e-56
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]             217   4e-56
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]             217   4e-56
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]             217   4e-56
gi|9506959 phosphodiesterase 7B [Homo sapiens]                        216   5e-56
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]             209   1e-53
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]             194   3e-49
gi|40254434 phosphodiesterase 3B [Homo sapiens]                       181   3e-45
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]             177   3e-44
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]             177   3e-44

>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
          Length = 736

 Score = 1476 bits (3821), Expect = 0.0
 Identities = 736/736 (100%), Positives = 736/736 (100%)

Query: 1   MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS 60
           MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
Sbjct: 1   MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS 60

Query: 61  ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL 120
           ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
Sbjct: 61  ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL 120

Query: 121 HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR 180
           HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
Sbjct: 121 HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR 180

Query: 181 NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR 240
           NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
Sbjct: 181 NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR 240

Query: 241 SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK 300
           SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
Sbjct: 241 SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK 300

Query: 301 KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH 360
           KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
Sbjct: 301 KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH 360

Query: 361 NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV 420
           NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
Sbjct: 361 NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV 420

Query: 421 LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL 480
           LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
Sbjct: 421 LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL 480

Query: 481 AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS 540
           AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
Sbjct: 481 AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS 540

Query: 541 SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI 600
           SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
Sbjct: 541 SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI 600

Query: 601 SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP 660
           SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
Sbjct: 601 SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP 660

Query: 661 SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG 720
           SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
Sbjct: 661 SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG 720

Query: 721 ETDIDIATEDKSPVDT 736
           ETDIDIATEDKSPVDT
Sbjct: 721 ETDIDIATEDKSPVDT 736


>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
          Length = 736

 Score = 1476 bits (3821), Expect = 0.0
 Identities = 736/736 (100%), Positives = 736/736 (100%)

Query: 1   MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS 60
           MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
Sbjct: 1   MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS 60

Query: 61  ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL 120
           ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
Sbjct: 61  ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL 120

Query: 121 HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR 180
           HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
Sbjct: 121 HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR 180

Query: 181 NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR 240
           NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
Sbjct: 181 NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR 240

Query: 241 SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK 300
           SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
Sbjct: 241 SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK 300

Query: 301 KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH 360
           KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
Sbjct: 301 KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH 360

Query: 361 NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV 420
           NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
Sbjct: 361 NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV 420

Query: 421 LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL 480
           LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
Sbjct: 421 LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL 480

Query: 481 AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS 540
           AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
Sbjct: 481 AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS 540

Query: 541 SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI 600
           SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
Sbjct: 541 SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI 600

Query: 601 SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP 660
           SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
Sbjct: 601 SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP 660

Query: 661 SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG 720
           SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
Sbjct: 661 SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG 720

Query: 721 ETDIDIATEDKSPVDT 736
           ETDIDIATEDKSPVDT
Sbjct: 721 ETDIDIATEDKSPVDT 736


>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
          Length = 721

 Score = 1295 bits (3352), Expect = 0.0
 Identities = 645/648 (99%), Positives = 646/648 (99%)

Query: 89  TVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKA 148
           TV+  CFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKA
Sbjct: 74  TVAHTCFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKA 133

Query: 149 MSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRV 208
           MSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRV
Sbjct: 134 MSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRV 193

Query: 209 NPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSG 268
           NPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSG
Sbjct: 194 NPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSG 253

Query: 269 NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRF 328
           NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRF
Sbjct: 254 NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRF 313

Query: 329 GVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTF 388
           GVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTF
Sbjct: 314 GVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTF 373

Query: 389 ITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDV 448
           ITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDV
Sbjct: 374 ITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDV 433

Query: 449 DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRK 508
           DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRK
Sbjct: 434 DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRK 493

Query: 509 MVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNP 568
           MVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNP
Sbjct: 494 MVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNP 553

Query: 569 TKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE 628
           TKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE
Sbjct: 554 TKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE 613

Query: 629 TWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEED 688
           TWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEED
Sbjct: 614 TWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEED 673

Query: 689 SEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT 736
           SEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
Sbjct: 674 SEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT 721


>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
          Length = 564

 Score = 1057 bits (2734), Expect = 0.0
 Identities = 531/554 (95%), Positives = 534/554 (96%), Gaps = 4/554 (0%)

Query: 187 TNLHGTSNKRSPAASQPPVSRVNP----QEESYQKLAMETLEELDWCLDQLETIQTYRSV 242
           T + G S   +  + QP      P     EESYQKLAMETLEELDWCLDQLETIQTYRSV
Sbjct: 11  TGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSV 70

Query: 243 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ 302
           SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ
Sbjct: 71  SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ 130

Query: 303 QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR 362
           QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR
Sbjct: 131 QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR 190

Query: 363 PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL 422
           PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL
Sbjct: 191 PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL 250

Query: 423 STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV 482
           STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV
Sbjct: 251 STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV 310

Query: 483 GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG 542
           GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG
Sbjct: 311 GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG 370

Query: 543 VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP 602
           VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP
Sbjct: 371 VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP 430

Query: 603 MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP 662
           MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP
Sbjct: 431 MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP 490

Query: 663 PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGET 722
           PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGET
Sbjct: 491 PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGET 550

Query: 723 DIDIATEDKSPVDT 736
           DIDIATEDKSPVDT
Sbjct: 551 DIDIATEDKSPVDT 564


>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
          Length = 673

 Score =  981 bits (2535), Expect = 0.0
 Identities = 496/629 (78%), Positives = 548/629 (87%), Gaps = 8/629 (1%)

Query: 94  CFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNS 153
           CFDV+NG S GRSPLDP  S  +GL+L A F  HSQRRESFLYRSDSDYDLSPK+MSRNS
Sbjct: 16  CFDVDNGTSAGRSPLDPMTSPGSGLILQANFV-HSQRRESFLYRSDSDYDLSPKSMSRNS 74

Query: 154 SLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTS-NKRSPAASQPPVSRVNPQE 212
           S+ S+ HGDDLIVTPFAQVLASLR+VRNNF  LTNL   + +KRSP  +QP +++    E
Sbjct: 75  SIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITE 134

Query: 213 ESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 272
           E+YQKLA ETLEELDWCLDQLET+QT  SVSEMASNKFKRMLNRELTHLSEMSRSGNQVS
Sbjct: 135 EAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 194

Query: 273 EYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNT 332
           E+ISNTFLDKQ++VEIPSPTQK++EKKK+   M+QISGVKKLMHSSSL N+SI RFGV T
Sbjct: 195 EFISNTFLDKQHEVEIPSPTQKEKEKKKRP--MSQISGVKKLMHSSSLTNSSIPRFGVKT 252

Query: 333 ENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYM 392
           E ED LAKELED+NKWGL++F +A  S NRPLT IM+ IFQERDLLKTF+I  DT ITY+
Sbjct: 253 EQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYL 312

Query: 393 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPG 452
           MTLEDHYH+DVAYHN++HAADV QSTHVLLSTPAL+AVFTDLEILAAIFA+AIHDVDHPG
Sbjct: 313 MTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPG 372

Query: 453 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVID 512
           VSNQFLINTNSELALMYND SVLENHHLAVGFKLLQEE+CDIF NLTKKQRQ+LRKMVID
Sbjct: 373 VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVID 432

Query: 513 MVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSL 572
           +VLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVL+NMVHCADLSNPTK L
Sbjct: 433 IVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL 492

Query: 573 ELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 632
           +LYRQWTDRIMEEFF+QGD+ERERGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWAD
Sbjct: 493 QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWAD 552

Query: 633 LVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGP 692
           LV PDAQDILDTLEDNR WYQS IPQSPSP  D+     QG  EKFQFELTL+E+     
Sbjct: 553 LVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDT 612

Query: 693 EKEG----EGHSYFSSTKTLCVIDPENRD 717
           EK+     E  +  S +KTLC  D E+ +
Sbjct: 613 EKDSGSQVEEDTSCSDSKTLCTQDSESTE 641


>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
          Length = 809

 Score =  977 bits (2526), Expect = 0.0
 Identities = 495/628 (78%), Positives = 547/628 (87%), Gaps = 8/628 (1%)

Query: 95  FDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSS 154
           FDV+NG S GRSPLDP  S  +GL+L A F  HSQRRESFLYRSDSDYDLSPK+MSRNSS
Sbjct: 153 FDVDNGTSAGRSPLDPMTSPGSGLILQANFV-HSQRRESFLYRSDSDYDLSPKSMSRNSS 211

Query: 155 LPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTS-NKRSPAASQPPVSRVNPQEE 213
           + S+ HGDDLIVTPFAQVLASLR+VRNNF  LTNL   + +KRSP  +QP +++    EE
Sbjct: 212 IASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEE 271

Query: 214 SYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE 273
           +YQKLA ETLEELDWCLDQLET+QT  SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE
Sbjct: 272 AYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE 331

Query: 274 YISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTE 333
           +ISNTFLDKQ++VEIPSPTQK++EKKK+   M+QISGVKKLMHSSSL N+SI RFGV TE
Sbjct: 332 FISNTFLDKQHEVEIPSPTQKEKEKKKRP--MSQISGVKKLMHSSSLTNSSIPRFGVKTE 389

Query: 334 NEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMM 393
            ED LAKELED+NKWGL++F +A  S NRPLT IM+ IFQERDLLKTF+I  DT ITY+M
Sbjct: 390 QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLM 449

Query: 394 TLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGV 453
           TLEDHYH+DVAYHN++HAADV QSTHVLLSTPAL+AVFTDLEILAAIFA+AIHDVDHPGV
Sbjct: 450 TLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGV 509

Query: 454 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDM 513
           SNQFLINTNSELALMYND SVLENHHLAVGFKLLQEE+CDIF NLTKKQRQ+LRKMVID+
Sbjct: 510 SNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDI 569

Query: 514 VLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLE 573
           VLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVL+NMVHCADLSNPTK L+
Sbjct: 570 VLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQ 629

Query: 574 LYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL 633
           LYRQWTDRIMEEFF+QGD+ERERGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWADL
Sbjct: 630 LYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADL 689

Query: 634 VQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPE 693
           V PDAQDILDTLEDNR WYQS IPQSPSP  D+     QG  EKFQFELTL+E+     E
Sbjct: 690 VHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTE 749

Query: 694 KEG----EGHSYFSSTKTLCVIDPENRD 717
           K+     E  +  S +KTLC  D E+ +
Sbjct: 750 KDSGSQVEEDTSCSDSKTLCTQDSESTE 777


>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
          Length = 860

 Score =  939 bits (2427), Expect = 0.0
 Identities = 490/664 (73%), Positives = 548/664 (82%), Gaps = 30/664 (4%)

Query: 54  PLSQRQSERARTPEGDGISRPTTLP--------LTTLPSIAITTVSQECFDVENGP--SP 103
           PL+ R   R R+P    +   +  P        L +   +     +   F+ ENGP  SP
Sbjct: 33  PLAPRAPRRPRSPPSSPVFFASPSPTFRRRLRLLRSCQDLGRQAWAGAGFEAENGPTPSP 92

Query: 104 GRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDD 163
           GRSPLD QAS   GLVLHA     SQRRESFLYRSDSDYD+SPK MSRNSS+ SE H +D
Sbjct: 93  GRSPLDSQASP--GLVLHAG-AATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAED 149

Query: 164 LIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETL 223
           LIVTPFAQVLASLRSVR+NF++LTN+   SNKRSP     PV +    EE+ Q+LA ETL
Sbjct: 150 LIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETL 209

Query: 224 EELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQ 283
           EELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSEMSRSGNQVSEYIS TFLDKQ
Sbjct: 210 EELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQ 269

Query: 284 NDVEIPSPTQKDREKKKKQ---------------QLMTQISGVKKLMHSSSLNNTSISRF 328
           N+VEIPSPT K+REK++                 Q M+QI+G+KKLMHS+SLNN++I RF
Sbjct: 270 NEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRF 329

Query: 329 GVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTF 388
           GV T+ E+ LA+ELE+LNKWGLNIF V+ Y+  R LTCIMY IFQERDLLK FRI  DT 
Sbjct: 330 GVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTM 389

Query: 389 ITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDV 448
           +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALDAVFTDLEILAA+FAAAIHDV
Sbjct: 390 VTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDV 449

Query: 449 DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRK 508
           DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQE++CDIF NL+K+QRQ+LRK
Sbjct: 450 DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRK 509

Query: 509 MVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNP 568
           MVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVLRNMVHCADLSNP
Sbjct: 510 MVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNP 569

Query: 569 TKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE 628
           TK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE
Sbjct: 570 TKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE 629

Query: 629 TWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNR--DCQGLMEKFQFELTLDE 686
           TWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++R      L +KFQFELTL+E
Sbjct: 630 TWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEE 689

Query: 687 EDSE 690
           E+ E
Sbjct: 690 EEEE 693


>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
          Length = 886

 Score =  938 bits (2425), Expect = 0.0
 Identities = 483/619 (78%), Positives = 534/619 (86%), Gaps = 22/619 (3%)

Query: 91  SQECFDVENGP--SPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKA 148
           S   F+ ENGP  SPGRSPLD QAS   GLVLHA     SQRRESFLYRSDSDYD+SPK 
Sbjct: 104 SSRRFEAENGPTPSPGRSPLDSQASP--GLVLHAG-AATSQRRESFLYRSDSDYDMSPKT 160

Query: 149 MSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRV 208
           MSRNSS+ SE H +DLIVTPFAQVLASLRSVR+NF++LTN+   SNKRSP     PV + 
Sbjct: 161 MSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKA 220

Query: 209 NPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSG 268
              EE+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSEMSRSG
Sbjct: 221 TLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSG 280

Query: 269 NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQISGVKK 313
           NQVSEYIS TFLDKQN+VEIPSPT K+REK++                 Q M+QI+G+KK
Sbjct: 281 NQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKK 340

Query: 314 LMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQ 373
           LMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+  R LTCIMY IFQ
Sbjct: 341 LMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQ 400

Query: 374 ERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTD 433
           ERDLLK FRI  DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALDAVFTD
Sbjct: 401 ERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTD 460

Query: 434 LEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCD 493
           LEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQE++CD
Sbjct: 461 LEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCD 520

Query: 494 IFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRI 553
           IF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRI
Sbjct: 521 IFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRI 580

Query: 554 QVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEK 613
           QVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHTASVEK
Sbjct: 581 QVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEK 640

Query: 614 SQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNR--DC 671
           SQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++R    
Sbjct: 641 SQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGH 700

Query: 672 QGLMEKFQFELTLDEEDSE 690
             L +KFQFELTL+EE+ E
Sbjct: 701 PPLPDKFQFELTLEEEEEE 719


>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
          Length = 825

 Score =  938 bits (2424), Expect = 0.0
 Identities = 482/615 (78%), Positives = 533/615 (86%), Gaps = 22/615 (3%)

Query: 95  FDVENGP--SPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRN 152
           F+ ENGP  SPGRSPLD QAS   GLVLHA     SQRRESFLYRSDSDYD+SPK MSRN
Sbjct: 47  FEAENGPTPSPGRSPLDSQASP--GLVLHAG-AATSQRRESFLYRSDSDYDMSPKTMSRN 103

Query: 153 SSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQE 212
           SS+ SE H +DLIVTPFAQVLASLRSVR+NF++LTN+   SNKRSP     PV +    E
Sbjct: 104 SSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSE 163

Query: 213 ESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 272
           E+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSEMSRSGNQVS
Sbjct: 164 ETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVS 223

Query: 273 EYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQISGVKKLMHS 317
           EYIS TFLDKQN+VEIPSPT K+REK++                 Q M+QI+G+KKLMHS
Sbjct: 224 EYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHS 283

Query: 318 SSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDL 377
           +SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+  R LTCIMY IFQERDL
Sbjct: 284 NSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDL 343

Query: 378 LKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEIL 437
           LK FRI  DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALDAVFTDLEIL
Sbjct: 344 LKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEIL 403

Query: 438 AAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMN 497
           AA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQE++CDIF N
Sbjct: 404 AALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQN 463

Query: 498 LTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLR 557
           L+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVLR
Sbjct: 464 LSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLR 523

Query: 558 NMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVG 617
           NMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHTASVEKSQVG
Sbjct: 524 NMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVG 583

Query: 618 FIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNR--DCQGLM 675
           FIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++R      L 
Sbjct: 584 FIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLP 643

Query: 676 EKFQFELTLDEEDSE 690
           +KFQFELTL+EE+ E
Sbjct: 644 DKFQFELTLEEEEEE 658


>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
          Length = 680

 Score =  856 bits (2211), Expect = 0.0
 Identities = 437/622 (70%), Positives = 512/622 (82%), Gaps = 11/622 (1%)

Query: 94  CFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNS 153
           CFD+ENG S GR  LDPQ+S   G ++ A  P HSQRRESFLYRSDSDY+LSPKAMSRNS
Sbjct: 49  CFDLENGLSCGRRALDPQSSPGLGRIMQAPVP-HSQRRESFLYRSDSDYELSPKAMSRNS 107

Query: 154 SLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGT-SNKRSPAASQPPVSRVNPQE 212
           S+ S+ HG+D+IVTPFAQVLASLR+VR+N   L       + K+ P  +    +++ P E
Sbjct: 108 SVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAE 167

Query: 213 ESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 272
           ++ QKLA+ETL+ELDWCLDQLET+QT  SV EMASNKFKR+LNRELTHLSE SRSGNQVS
Sbjct: 168 DTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVS 227

Query: 273 EYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNT 332
           EYIS TFLD+Q +VE+P  T ++       Q M++ISG+  L HS+SL++ ++ RFGV T
Sbjct: 228 EYISRTFLDQQTEVELPKVTAEEAP-----QPMSRISGLHGLCHSASLSSATVPRFGVQT 282

Query: 333 ENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYM 392
           + E+ LAKELED NKWGL++F VA  S NRPLT I+++IFQERDLLKTF+I +DT  TY+
Sbjct: 283 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 342

Query: 393 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPG 452
           + LE HYH++VAYHNSLHAADVAQSTHVLL+TPAL+AVFTDLEILAA+FA+AIHDVDHPG
Sbjct: 343 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 402

Query: 453 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVID 512
           VSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ E+CDIF NL+ KQR +LR+MVID
Sbjct: 403 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVID 462

Query: 513 MVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSL 572
           MVLATDMSKHM+LLADLKTMVETKKVTS GVLLLDNY+DRIQVL+N+VHCADLSNPTK L
Sbjct: 463 MVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPL 522

Query: 573 ELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 632
            LYRQWTDRIM EFFQQGD+ERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWAD
Sbjct: 523 PLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWAD 582

Query: 633 LVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGP 692
           LV PDAQD+LDTLEDNR WYQS IP+SPS   D  N +  G  ++FQFELTL+E + E  
Sbjct: 583 LVHPDAQDLLDTLEDNREWYQSKIPRSPS---DLTNPERDG-PDRFQFELTLEEAEEEDE 638

Query: 693 EKEGEGHSYFSSTKTLCVIDPE 714
           E+E EG     + + L + D E
Sbjct: 639 EEEEEGEETALAKEALELPDTE 660


>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
          Length = 712

 Score =  852 bits (2202), Expect = 0.0
 Identities = 436/621 (70%), Positives = 511/621 (82%), Gaps = 11/621 (1%)

Query: 95  FDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSS 154
           FD+ENG S GR  LDPQ+S   G ++ A  P HSQRRESFLYRSDSDY+LSPKAMSRNSS
Sbjct: 82  FDLENGLSCGRRALDPQSSPGLGRIMQAPVP-HSQRRESFLYRSDSDYELSPKAMSRNSS 140

Query: 155 LPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGT-SNKRSPAASQPPVSRVNPQEE 213
           + S+ HG+D+IVTPFAQVLASLR+VR+N   L       + K+ P  +    +++ P E+
Sbjct: 141 VASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAED 200

Query: 214 SYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE 273
           + QKLA+ETL+ELDWCLDQLET+QT  SV EMASNKFKR+LNRELTHLSE SRSGNQVSE
Sbjct: 201 TGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSE 260

Query: 274 YISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTE 333
           YIS TFLD+Q +VE+P  T ++       Q M++ISG+  L HS+SL++ ++ RFGV T+
Sbjct: 261 YISRTFLDQQTEVELPKVTAEEAP-----QPMSRISGLHGLCHSASLSSATVPRFGVQTD 315

Query: 334 NEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMM 393
            E+ LAKELED NKWGL++F VA  S NRPLT I+++IFQERDLLKTF+I +DT  TY++
Sbjct: 316 QEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLL 375

Query: 394 TLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGV 453
            LE HYH++VAYHNSLHAADVAQSTHVLL+TPAL+AVFTDLEILAA+FA+AIHDVDHPGV
Sbjct: 376 MLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGV 435

Query: 454 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDM 513
           SNQFLINTNSELALMYND SVLENHHLAVGFKLLQ E+CDIF NL+ KQR +LR+MVIDM
Sbjct: 436 SNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDM 495

Query: 514 VLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLE 573
           VLATDMSKHM+LLADLKTMVETKKVTS GVLLLDNY+DRIQVL+N+VHCADLSNPTK L 
Sbjct: 496 VLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLP 555

Query: 574 LYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL 633
           LYRQWTDRIM EFFQQGD+ERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADL
Sbjct: 556 LYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADL 615

Query: 634 VQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPE 693
           V PDAQD+LDTLEDNR WYQS IP+SPS   D  N +  G  ++FQFELTL+E + E  E
Sbjct: 616 VHPDAQDLLDTLEDNREWYQSKIPRSPS---DLTNPERDG-PDRFQFELTLEEAEEEDEE 671

Query: 694 KEGEGHSYFSSTKTLCVIDPE 714
           +E EG     + + L + D E
Sbjct: 672 EEEEGEETALAKEALELPDTE 692


>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
          Length = 606

 Score =  826 bits (2134), Expect = 0.0
 Identities = 420/589 (71%), Positives = 491/589 (83%), Gaps = 10/589 (1%)

Query: 127 HSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTIL 186
           HSQRRESFLYRSDSDY+LSPKAMSRNSS+ S+ HG+D+IVTPFAQVLASLR+VR+N   L
Sbjct: 7   HSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAAL 66

Query: 187 TNLHGT-SNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEM 245
                  + K+ P  +    +++ P E++ QKLA+ETL+ELDWCLDQLET+QT  SV EM
Sbjct: 67  ARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEM 126

Query: 246 ASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLM 305
           ASNKFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q +VE+P  T ++       Q M
Sbjct: 127 ASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAP-----QPM 181

Query: 306 TQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLT 365
           ++ISG+  L HS+SL++ ++ RFGV T+ E+ LAKELED NKWGL++F VA  S NRPLT
Sbjct: 182 SRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLT 241

Query: 366 CIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTP 425
            I+++IFQERDLLKTF+I +DT  TY++ LE HYH++VAYHNSLHAADVAQSTHVLL+TP
Sbjct: 242 AIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATP 301

Query: 426 ALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFK 485
           AL+AVFTDLEILAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFK
Sbjct: 302 ALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 361

Query: 486 LLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLL 545
           LLQ E+CDIF NL+ KQR +LR+MVIDMVLATDMSKHM+LLADLKTMVETKKVTS GVLL
Sbjct: 362 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 421

Query: 546 LDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCD 605
           LDNY+DRIQVL+N+VHCADLSNPTK L LYRQWTDRIM EFFQQGD+ERE G++ISPMCD
Sbjct: 422 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 481

Query: 606 KHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLD 665
           KHTASVEKSQVGFIDYI HPLWETWADLV PDAQD+LDTLEDNR WYQS IP+SPS   D
Sbjct: 482 KHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS---D 538

Query: 666 EQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPE 714
             N +  G  ++FQFELTL+E + E  E+E EG     + + L + D E
Sbjct: 539 LTNPERDG-PDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTE 586


>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
          Length = 647

 Score =  736 bits (1900), Expect = 0.0
 Identities = 370/460 (80%), Positives = 409/460 (88%), Gaps = 17/460 (3%)

Query: 248 NKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ----- 302
           ++FKRMLNRELTHLSEMSRSGNQVSEYIS TFLDKQN+VEIPSPT K+REK++       
Sbjct: 21  DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80

Query: 303 ----------QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNI 352
                     Q M+QI+G+KKLMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNI
Sbjct: 81  QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140

Query: 353 FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA 412
           F V+ Y+  R LTCIMY IFQERDLLK FRI  DT +TYM+TLEDHYH+DVAYHNSLHAA
Sbjct: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200

Query: 413 DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 472
           DV QSTHVLL+TPALDAVFTDLEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDE
Sbjct: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260

Query: 473 SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM 532
           SVLENHHLAVGFKLLQE++CDIF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTM
Sbjct: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320

Query: 533 VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK 592
           VETKKVTSSGVLLLDNY+DRIQVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+
Sbjct: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380

Query: 593 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY 652
           ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY
Sbjct: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440

Query: 653 QSMIPQSPSPPLDEQNR--DCQGLMEKFQFELTLDEEDSE 690
            S I QSPSPP +E++R      L +KFQFELTL+EE+ E
Sbjct: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 480


>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
          Length = 535

 Score =  235 bits (599), Expect = 1e-61
 Identities = 119/292 (40%), Positives = 182/292 (62%), Gaps = 12/292 (4%)

Query: 342 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 401
           L+D++KW  ++F +   S    L  ++Y +F   DL+  F+I     IT+   LE  Y  
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213

Query: 402 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 460
               YHN +HAADV Q+ H ++    +    T+LEILA +FAAAIHD +H G +N F I 
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273

Query: 461 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 520
           T S++A++YND SVLENHH++  ++L+QEE  +I +NL+K   + LR +VI+MVL+TDMS
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333

Query: 521 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 580
            H   + +++  ++  +    G+       DR + +  ++H AD+S+P KS +L+ +WT 
Sbjct: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382

Query: 581 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 632
            +MEEFF QGDKE E G+  SP+CD+ +  V +SQ+GFID+IV P +    D
Sbjct: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434


>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
          Length = 545

 Score =  235 bits (599), Expect = 1e-61
 Identities = 119/292 (40%), Positives = 182/292 (62%), Gaps = 12/292 (4%)

Query: 342 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 401
           L+D++KW  ++F +   S    L  ++Y +F   DL+  F+I     IT+   LE  Y  
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213

Query: 402 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 460
               YHN +HAADV Q+ H ++    +    T+LEILA +FAAAIHD +H G +N F I 
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273

Query: 461 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 520
           T S++A++YND SVLENHH++  ++L+QEE  +I +NL+K   + LR +VI+MVL+TDMS
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333

Query: 521 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 580
            H   + +++  ++  +    G+       DR + +  ++H AD+S+P KS +L+ +WT 
Sbjct: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382

Query: 581 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 632
            +MEEFF QGDKE E G+  SP+CD+ +  V +SQ+GFID+IV P +    D
Sbjct: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434


>gi|4505677 phosphodiesterase 1B [Homo sapiens]
          Length = 536

 Score =  233 bits (594), Expect = 5e-61
 Identities = 125/330 (37%), Positives = 198/330 (60%), Gaps = 15/330 (4%)

Query: 342 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 401
           L++L+ W  ++F++   + +  L  I++ +    +L+  F+I +   ++++  LE  Y  
Sbjct: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217

Query: 402 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 460
               YHN +HAADV Q+ H  L    +    +++E+LA IFAAAIHD +H G +N F I 
Sbjct: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277

Query: 461 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 520
           T SE A++YND SVLENHH++  F+L+Q++  +IF+NLTK +   LR +VI+MVLATDMS
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337

Query: 521 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 580
            H   +  +KT ++  +             D+ + L  ++H AD+S+PTK   ++ +WT 
Sbjct: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386

Query: 581 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQD 640
            +MEEFF+QGDKE E G+  SP+CD+ +  V +SQ+GFID+IV P +    D+ +   Q 
Sbjct: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446

Query: 641 ILDTLEDNRNWYQSMIPQSPSPPLDEQNRD 670
           + D  ED+++  Q    Q   P LD +  D
Sbjct: 447 LAD--EDSKSKNQPSF-QWRQPSLDVEVGD 473


>gi|4826894 phosphodiesterase 1C [Homo sapiens]
          Length = 634

 Score =  231 bits (588), Expect = 2e-60
 Identities = 133/397 (33%), Positives = 222/397 (55%), Gaps = 26/397 (6%)

Query: 251 KRMLNRELTHLSEMSRSG--NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQI 308
           +R+L+ E   LS++      ++V +++++TF  +Q  + +    +K R K     +   I
Sbjct: 81  RRLLDTE-DELSDIQSDAVPSEVRDWLASTFT-RQMGMMLRRSDEKPRFKSIVHAVQAGI 138

Query: 309 SGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIM 368
              +    +S++         V       + + L+D++KW  ++F++   S +  L  I 
Sbjct: 139 FVERMYRRTSNM---------VGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIF 189

Query: 369 YAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV-AYHNSLHAADVAQSTHVLLSTPAL 427
           Y +    DL+  F+I     ++++  LE  Y      YHN +HAADV Q+ H LL    +
Sbjct: 190 YELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGV 249

Query: 428 DAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLL 487
               T+LEI A IF+AAIHD +H G +N F I T S+ A++YND SVLENHHL+  ++LL
Sbjct: 250 ANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLL 309

Query: 488 Q-EEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLL 546
           Q +E  +I +NL+K   +  R +VI+MV+ATDMS H   +  +KT ++  +         
Sbjct: 310 QDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-------- 361

Query: 547 DNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDK 606
               ++ + L  M+H AD+S+P K+ +L+ +WT  ++EEFF+QGD+E E G+  SP+CD+
Sbjct: 362 ---IEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR 418

Query: 607 HTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILD 643
            +  V +SQVGFID+IV P +    D+ +     ++D
Sbjct: 419 KSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLID 455


>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
          Length = 783

 Score =  226 bits (577), Expect = 4e-59
 Identities = 119/331 (35%), Positives = 193/331 (58%), Gaps = 15/331 (4%)

Query: 338 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 397
           +A+ +E+   W  +IF +   +HNRPL  +   +F    + +    S  T  +++  +E 
Sbjct: 442 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 501

Query: 398 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 457
           +YHS   YHNS H+ADV  +T   LS   +      ++ +AA+ AA IHDVDHPG +N F
Sbjct: 502 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 561

Query: 458 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EEHCDIFMNLTKKQRQTLRKMVIDMVLA 516
           L N  SELA++YND +VLE+HH A+ F+L   ++ C+IF N+ +   +TLR+ +IDMVLA
Sbjct: 562 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 621

Query: 517 TDMSKHM-----------SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADL 565
           T+M+KH              LA L+   ET K       +L    +R  + R ++ CAD+
Sbjct: 622 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 681

Query: 566 SNPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 624
           SNP + L+   +W  RI EE+F Q D+E+++G+  + P+ D++T S+ KSQ+ FIDY + 
Sbjct: 682 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 741

Query: 625 PLWETWADLVQPDAQDILDTLEDNRNWYQSM 655
            +++ W   V  D  D++  L++N  +++ +
Sbjct: 742 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGL 770


>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
          Length = 829

 Score =  226 bits (577), Expect = 4e-59
 Identities = 119/331 (35%), Positives = 193/331 (58%), Gaps = 15/331 (4%)

Query: 338 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 397
           +A+ +E+   W  +IF +   +HNRPL  +   +F    + +    S  T  +++  +E 
Sbjct: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547

Query: 398 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 457
           +YHS   YHNS H+ADV  +T   LS   +      ++ +AA+ AA IHDVDHPG +N F
Sbjct: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607

Query: 458 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EEHCDIFMNLTKKQRQTLRKMVIDMVLA 516
           L N  SELA++YND +VLE+HH A+ F+L   ++ C+IF N+ +   +TLR+ +IDMVLA
Sbjct: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667

Query: 517 TDMSKHM-----------SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADL 565
           T+M+KH              LA L+   ET K       +L    +R  + R ++ CAD+
Sbjct: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727

Query: 566 SNPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 624
           SNP + L+   +W  RI EE+F Q D+E+++G+  + P+ D++T S+ KSQ+ FIDY + 
Sbjct: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787

Query: 625 PLWETWADLVQPDAQDILDTLEDNRNWYQSM 655
            +++ W   V  D  D++  L++N  +++ +
Sbjct: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGL 816


>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
          Length = 838

 Score =  217 bits (552), Expect = 4e-56
 Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)

Query: 338 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 397
           +++ L++   W  NIF +   +H RPL  +   +F    + +    S  T   +   +E 
Sbjct: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559

Query: 398 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 457
           +YHS  AYHNS HAADV  +T   L    +      L+ +AA+ AA +HDVDHPG +N F
Sbjct: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619

Query: 458 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 516
           L N  SELA++YND +VLE+HH A+ F+L +++  C+IF N+ +   +TLR+ +IDMVLA
Sbjct: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679

Query: 517 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 566
           T+M+KH         S+   +   +E    +   +G    +N   +I + R M+ CAD++
Sbjct: 680 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 736

Query: 567 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 625
           NP + L+L  +W  RI EE+F Q D+E+ +G+  + P+ D++T S+ KSQ+ FIDY +  
Sbjct: 737 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 796

Query: 626 LWETWADLVQPDAQDILDTLEDN-RNW 651
           +++ W       A  ++  L DN ++W
Sbjct: 797 MFDAWDAFAHLPA--LMQHLADNYKHW 821


>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
          Length = 865

 Score =  217 bits (552), Expect = 4e-56
 Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)

Query: 338 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 397
           +++ L++   W  NIF +   +H RPL  +   +F    + +    S  T   +   +E 
Sbjct: 527 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 586

Query: 398 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 457
           +YHS  AYHNS HAADV  +T   L    +      L+ +AA+ AA +HDVDHPG +N F
Sbjct: 587 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 646

Query: 458 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 516
           L N  SELA++YND +VLE+HH A+ F+L +++  C+IF N+ +   +TLR+ +IDMVLA
Sbjct: 647 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 706

Query: 517 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 566
           T+M+KH         S+   +   +E    +   +G    +N   +I + R M+ CAD++
Sbjct: 707 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 763

Query: 567 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 625
           NP + L+L  +W  RI EE+F Q D+E+ +G+  + P+ D++T S+ KSQ+ FIDY +  
Sbjct: 764 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 823

Query: 626 LWETWADLVQPDAQDILDTLEDN-RNW 651
           +++ W       A  ++  L DN ++W
Sbjct: 824 MFDAWDAFAHLPA--LMQHLADNYKHW 848


>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
          Length = 830

 Score =  217 bits (552), Expect = 4e-56
 Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)

Query: 338 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 397
           +++ L++   W  NIF +   +H RPL  +   +F    + +    S  T   +   +E 
Sbjct: 492 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 551

Query: 398 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 457
           +YHS  AYHNS HAADV  +T   L    +      L+ +AA+ AA +HDVDHPG +N F
Sbjct: 552 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 611

Query: 458 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 516
           L N  SELA++YND +VLE+HH A+ F+L +++  C+IF N+ +   +TLR+ +IDMVLA
Sbjct: 612 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 671

Query: 517 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 566
           T+M+KH         S+   +   +E    +   +G    +N   +I + R M+ CAD++
Sbjct: 672 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 728

Query: 567 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 625
           NP + L+L  +W  RI EE+F Q D+E+ +G+  + P+ D++T S+ KSQ+ FIDY +  
Sbjct: 729 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 788

Query: 626 LWETWADLVQPDAQDILDTLEDN-RNW 651
           +++ W       A  ++  L DN ++W
Sbjct: 789 MFDAWDAFAHLPA--LMQHLADNYKHW 813


>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
          Length = 788

 Score =  217 bits (552), Expect = 4e-56
 Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)

Query: 338 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 397
           +++ L++   W  NIF +   +H RPL  +   +F    + +    S  T   +   +E 
Sbjct: 450 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 509

Query: 398 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 457
           +YHS  AYHNS HAADV  +T   L    +      L+ +AA+ AA +HDVDHPG +N F
Sbjct: 510 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 569

Query: 458 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 516
           L N  SELA++YND +VLE+HH A+ F+L +++  C+IF N+ +   +TLR+ +IDMVLA
Sbjct: 570 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 629

Query: 517 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 566
           T+M+KH         S+   +   +E    +   +G    +N   +I + R M+ CAD++
Sbjct: 630 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 686

Query: 567 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 625
           NP + L+L  +W  RI EE+F Q D+E+ +G+  + P+ D++T S+ KSQ+ FIDY +  
Sbjct: 687 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 746

Query: 626 LWETWADLVQPDAQDILDTLEDN-RNW 651
           +++ W       A  ++  L DN ++W
Sbjct: 747 MFDAWDAFAHLPA--LMQHLADNYKHW 771


>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
          Length = 885

 Score =  217 bits (552), Expect = 4e-56
 Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)

Query: 338 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 397
           +++ L++   W  NIF +   +H RPL  +   +F    + +    S  T   +   +E 
Sbjct: 547 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 606

Query: 398 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 457
           +YHS  AYHNS HAADV  +T   L    +      L+ +AA+ AA +HDVDHPG +N F
Sbjct: 607 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 666

Query: 458 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 516
           L N  SELA++YND +VLE+HH A+ F+L +++  C+IF N+ +   +TLR+ +IDMVLA
Sbjct: 667 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 726

Query: 517 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 566
           T+M+KH         S+   +   +E    +   +G    +N   +I + R M+ CAD++
Sbjct: 727 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 783

Query: 567 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 625
           NP + L+L  +W  RI EE+F Q D+E+ +G+  + P+ D++T S+ KSQ+ FIDY +  
Sbjct: 784 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 843

Query: 626 LWETWADLVQPDAQDILDTLEDN-RNW 651
           +++ W       A  ++  L DN ++W
Sbjct: 844 MFDAWDAFAHLPA--LMQHLADNYKHW 868


>gi|9506959 phosphodiesterase 7B [Homo sapiens]
          Length = 450

 Score =  216 bits (551), Expect = 5e-56
 Identities = 120/366 (32%), Positives = 208/366 (56%), Gaps = 17/366 (4%)

Query: 298 KKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNK---WGLNIFN 354
           KKK ++L++     ++  H+S L    I +  ++  +ED+L +    L+K   W  +IF 
Sbjct: 66  KKKVKRLLS----FQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFL 121

Query: 355 VAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADV 414
               ++   L  ++  +F    L+  F++   T   +++ +++ YHS   YHN++HAADV
Sbjct: 122 FDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADV 181

Query: 415 AQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 474
            Q+ H  L  P L +  T L+I+  + AAA HDVDHPGV+  FLI TN  LA +Y + SV
Sbjct: 182 TQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSV 241

Query: 475 LENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVE 534
           LENHH      +L+E    +  +L K+  Q + + +  ++LATD+++    L  LK  + 
Sbjct: 242 LENHHWRSTIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLH 299

Query: 535 TKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKER 594
            K       L L++  DR  +L+  + CAD+ NP +  E+ +QW++R+ EEF++QG+ E+
Sbjct: 300 NKD------LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQ 353

Query: 595 ERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPD--AQDILDTLEDNRNWY 652
           +  +EISP+C++   S+   Q+GF+ YIV PL+  WA        ++++L  L  N+  +
Sbjct: 354 KFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQW 413

Query: 653 QSMIPQ 658
           +S++P+
Sbjct: 414 KSLLPR 419


>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
          Length = 456

 Score =  209 bits (531), Expect = 1e-53
 Identities = 120/372 (32%), Positives = 199/372 (53%), Gaps = 23/372 (6%)

Query: 263 EMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNN 322
           E  R G+    YI       Q+++E+    +  R           +S  + L  S     
Sbjct: 52  ESERRGSH--PYIDFRIFHSQSEIEVSVSARNIRRL---------LSFQRYLRSSRFFRG 100

Query: 323 TSISRFGVNTENEDHLAKE---LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLK 379
           T++S   +N  ++D+  +    LE +  W  +IF     ++   L  + + +F    L++
Sbjct: 101 TAVSN-SLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIE 159

Query: 380 TFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAA 439
            F +       +++ +++ YHS   YHN++HAADV Q+ H  L  P L    T  +IL +
Sbjct: 160 YFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLS 219

Query: 440 IFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLT 499
           + AAA HD+DHPGV+  FLI TN  LA +Y + SVLENHH      LL+E    +F +L 
Sbjct: 220 LIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLP 277

Query: 500 KKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNM 559
            + RQ +   +  ++LATD+S+    L+  ++ ++       G L L++   R  VL+  
Sbjct: 278 LESRQQMETQIGALILATDISRQNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMA 331

Query: 560 VHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFI 619
           + CAD+ NP ++ EL +QW++++ EEFF QGD E++  + +SP+CD+HT S+   Q+GF+
Sbjct: 332 LKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFM 391

Query: 620 DYIVHPLWETWA 631
            Y+V PL+  WA
Sbjct: 392 TYLVEPLFTEWA 403


>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
          Length = 424

 Score =  194 bits (492), Expect = 3e-49
 Identities = 125/429 (29%), Positives = 221/429 (51%), Gaps = 29/429 (6%)

Query: 204 PVSRVNPQEESYQK--LAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHL 261
           P+ R  PQ    ++  ++  +   L  C +  +  Q   ++S  +S++    + R L  +
Sbjct: 11  PLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYI-RMLGDV 69

Query: 262 SEMSRSGNQVSEYISNTFLD-----KQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMH 316
              SR+G +     S+ ++D      Q+++E+    +  R           +S  + L  
Sbjct: 70  RVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRL---------LSFQRYLRS 120

Query: 317 SSSLNNTSISRFGVNTENEDHLAKE---LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQ 373
           S     T++S   +N  ++D+  +    LE +  W  +IF     ++   L  + + +F 
Sbjct: 121 SRFFRGTAVSN-SLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFS 179

Query: 374 ERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTD 433
              L++ F +       +++ +++ YHS   YHN++HAADV Q+ H  L  P L    T 
Sbjct: 180 LHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTP 239

Query: 434 LEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCD 493
            +IL ++ AAA HD+DHPGV+  FLI TN  LA +Y + SVLENHH      LL+E    
Sbjct: 240 WDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES--G 297

Query: 494 IFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRI 553
           +F +L  + RQ +   +  ++LATD+S+    L+  ++ ++       G L L++   R 
Sbjct: 298 LFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLD------RGDLCLEDTRHRH 351

Query: 554 QVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEK 613
            VL+  + CAD+ NP ++ EL +QW++++ EEFF QGD E++  + +SP+CD+HT S+  
Sbjct: 352 LVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIAN 411

Query: 614 SQVGFIDYI 622
            Q+G   Y+
Sbjct: 412 IQIGNYTYL 420


>gi|40254434 phosphodiesterase 3B [Homo sapiens]
          Length = 1112

 Score =  181 bits (458), Expect = 3e-45
 Identities = 120/392 (30%), Positives = 187/392 (47%), Gaps = 60/392 (15%)

Query: 292  TQKDREKKKKQQLMTQISGVKKLMHSSSLNNTS-----ISRFGVNTENEDHLAKELEDLN 346
            TQ++ E +KK        G K L   +     +     +S   +  E  D L   +E ++
Sbjct: 619  TQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSL---IEKMS 675

Query: 347  KWGLNIFNVA---GYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV 403
             W   IF +    G    R L+ +MY +FQ+  LL+ F+I +  F+ Y   LE+ Y  D+
Sbjct: 676  NWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYR-DI 734

Query: 404  AYHNSLHAADVAQSTHVLLSTPA------------------------------------- 426
             YHN +HA DV  +   L + P                                      
Sbjct: 735  PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSN 794

Query: 427  -------LDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH 479
                   L +    LE++A   AAA+HD DHPG +N FL+ TN+  A++YND SVLENHH
Sbjct: 795  PDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHH 854

Query: 480  LAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKV 538
             A  + L L     +  ++L   + +  R +VI+ +LATD+ KH   LA+     +   V
Sbjct: 855  AASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA--KANDV 912

Query: 539  TSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGM 598
             S+G+    N  DR+ V +  +  AD++ P K  +L+ +WT+ I+ EF++QGD+E   G+
Sbjct: 913  NSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGL 971

Query: 599  EISPMCDKHTASVEKSQVGFIDYIVHPLWETW 630
             ISP  D+ +  + K Q  FI +IV PL  ++
Sbjct: 972  PISPFMDRSSPQLAKLQESFITHIVGPLCNSY 1003


>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
          Length = 386

 Score =  177 bits (449), Expect = 3e-44
 Identities = 101/341 (29%), Positives = 187/341 (54%), Gaps = 13/341 (3%)

Query: 353 FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA 412
           F+V  +  N  L+C+ + ++ +  L++ F I+  T   ++  + D+Y ++  +HN  H  
Sbjct: 54  FDVWLWEPNEMLSCLEH-MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCF 111

Query: 413 DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 472
            VAQ  + ++   +L   F+  +IL  + AA  HD+DHPG +N + IN  +ELA+ YND 
Sbjct: 112 CVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 171

Query: 473 SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM 532
           S LENHH AV F++L E  C+IF N+     + +R+ +I ++LATDM++H  ++   K  
Sbjct: 172 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 231

Query: 533 VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK 592
           +E    ++   + L        +   ++ C D+SN  + +E+   W D ++EE+F Q D+
Sbjct: 232 MENFDYSNEEHMTL--------LKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDR 283

Query: 593 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY 652
           E+  G+ ++P  D+   +   +Q+GFI +++ P++ET   L     + +L  L ++R+ Y
Sbjct: 284 EKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRY 343

Query: 653 QSM--IPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEG 691
           + +  I  +      + +    G  EK + E + D ++SEG
Sbjct: 344 EELKRIDDAMKELQKKTDSLTSGATEKSR-ERSRDVKNSEG 383


>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
          Length = 386

 Score =  177 bits (449), Expect = 3e-44
 Identities = 101/341 (29%), Positives = 187/341 (54%), Gaps = 13/341 (3%)

Query: 353 FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA 412
           F+V  +  N  L+C+ + ++ +  L++ F I+  T   ++  + D+Y ++  +HN  H  
Sbjct: 54  FDVWLWEPNEMLSCLEH-MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCF 111

Query: 413 DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 472
            VAQ  + ++   +L   F+  +IL  + AA  HD+DHPG +N + IN  +ELA+ YND 
Sbjct: 112 CVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 171

Query: 473 SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM 532
           S LENHH AV F++L E  C+IF N+     + +R+ +I ++LATDM++H  ++   K  
Sbjct: 172 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 231

Query: 533 VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK 592
           +E    ++   + L        +   ++ C D+SN  + +E+   W D ++EE+F Q D+
Sbjct: 232 MENFDYSNEEHMTL--------LKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDR 283

Query: 593 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY 652
           E+  G+ ++P  D+   +   +Q+GFI +++ P++ET   L     + +L  L ++R+ Y
Sbjct: 284 EKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRY 343

Query: 653 QSM--IPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEG 691
           + +  I  +      + +    G  EK + E + D ++SEG
Sbjct: 344 EELKRIDDAMKELQKKTDSLTSGATEKSR-ERSRDVKNSEG 383


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.129    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,743,580
Number of Sequences: 37866
Number of extensions: 1272284
Number of successful extensions: 4933
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 4582
Number of HSP's gapped (non-prelim): 269
length of query: 736
length of database: 18,247,518
effective HSP length: 110
effective length of query: 626
effective length of database: 14,082,258
effective search space: 8815493508
effective search space used: 8815493508
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.