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Search of human proteins with 31563507
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo
sapiens]
(1684 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 3215 0.0
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 250 9e-66
gi|83267877 RANBP2-like and GRIP domain containing 5 isoform 1 [... 241 3e-63
gi|182765478 RANBP2-like and GRIP domain containing 6 [Homo sapi... 241 3e-63
gi|169162953 PREDICTED: RANBP2-like and GRIP domain containing 8... 239 1e-62
gi|71061468 centromere protein E [Homo sapiens] 230 8e-60
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 228 5e-59
gi|211059431 RANBP2-like and GRIP domain containing 4 [Homo sapi... 224 4e-58
gi|221307607 RANBP2-like and GRIP domain containing 3 [Homo sapi... 218 3e-56
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 216 1e-55
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 216 1e-55
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 216 1e-55
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 216 1e-55
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 216 1e-55
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 216 1e-55
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 216 1e-55
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 216 1e-55
gi|157266273 RANBP2-like and GRIP domain containing 1 [Homo sapi... 211 6e-54
gi|118200331 RANBP2-like and GRIP domain containing 2 [Homo sapi... 211 6e-54
gi|148536869 ninein isoform 2 [Homo sapiens] 207 7e-53
gi|33946313 ninein isoform 4 [Homo sapiens] 206 2e-52
gi|33946321 ninein isoform 5 [Homo sapiens] 206 2e-52
gi|148536871 ninein isoform 1 [Homo sapiens] 206 2e-52
gi|21735548 centrosomal protein 2 [Homo sapiens] 202 2e-51
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 202 3e-51
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 200 8e-51
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 197 9e-50
gi|55770834 centromere protein F [Homo sapiens] 197 9e-50
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 194 6e-49
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 194 8e-49
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 3215 bits (8336), Expect = 0.0
Identities = 1684/1684 (100%), Positives = 1684/1684 (100%)
Query: 1 MEDLVQDGVASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRS 60
MEDLVQDGVASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRS
Sbjct: 1 MEDLVQDGVASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRS 60
Query: 61 KPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKEL 120
KPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKEL
Sbjct: 61 KPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKEL 120
Query: 121 EQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNV 180
EQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNV
Sbjct: 121 EQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNV 180
Query: 181 KKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEE 240
KKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEE
Sbjct: 181 KKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEE 240
Query: 241 LLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELE 300
LLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELE
Sbjct: 241 LLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELE 300
Query: 301 NLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNN 360
NLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNN
Sbjct: 301 NLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNN 360
Query: 361 LKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVE 420
LKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVE
Sbjct: 361 LKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVE 420
Query: 421 QHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNY 480
QHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNY
Sbjct: 421 QHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNY 480
Query: 481 ESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRL 540
ESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRL
Sbjct: 481 ESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRL 540
Query: 541 QGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFI 600
QGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFI
Sbjct: 541 QGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFI 600
Query: 601 NKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKD 660
NKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKD
Sbjct: 601 NKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKD 660
Query: 661 QNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVIL 720
QNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVIL
Sbjct: 661 QNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVIL 720
Query: 721 KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV 780
KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV
Sbjct: 721 KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV 780
Query: 781 NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840
NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK
Sbjct: 781 NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840
Query: 841 VLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEK 900
VLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEK
Sbjct: 841 VLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEK 900
Query: 901 CFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKEC 960
CFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKEC
Sbjct: 901 CFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKEC 960
Query: 961 KEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYK 1020
KEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYK
Sbjct: 961 KEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYK 1020
Query: 1021 NLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQS 1080
NLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQS
Sbjct: 1021 NLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQS 1080
Query: 1081 NAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQK 1140
NAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQK
Sbjct: 1081 NAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQK 1140
Query: 1141 TMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETL 1200
TMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETL
Sbjct: 1141 TMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETL 1200
Query: 1201 QEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQV 1260
QEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQV
Sbjct: 1201 QEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQV 1260
Query: 1261 EVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEF 1320
EVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEF
Sbjct: 1261 EVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEF 1320
Query: 1321 ESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQ 1380
ESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQ
Sbjct: 1321 ESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQ 1380
Query: 1381 TLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLR 1440
TLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLR
Sbjct: 1381 TLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLR 1440
Query: 1441 NSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNT 1500
NSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNT
Sbjct: 1441 NSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNT 1500
Query: 1501 DLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEE 1560
DLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEE
Sbjct: 1501 DLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEE 1560
Query: 1561 LVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLK 1620
LVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLK
Sbjct: 1561 LVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLK 1620
Query: 1621 NVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRSSGWASYLHSW 1680
NVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRSSGWASYLHSW
Sbjct: 1621 NVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRSSGWASYLHSW 1680
Query: 1681 SGLR 1684
SGLR
Sbjct: 1681 SGLR 1684
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 250 bits (638), Expect = 9e-66
Identities = 408/1866 (21%), Positives = 799/1866 (42%), Gaps = 330/1866 (17%)
Query: 20 SKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLD 79
S+ E + + + K++++ + K S E ++++L K + ++ K L R
Sbjct: 448 SEEERISLQQELSRVKQEVVDVMKKSSE--EQIAKLQKLHEKELARKEQELTKKLQTR-- 503
Query: 80 ALLLEKAETEQQCLSLKK---ENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIEN--- 133
E+ EQ ++L+K E +K+ QE E + A +ELE + E EN
Sbjct: 504 ----EREFQEQMKVALEKSQSEYLKISQEKEQQESL---ALEELELQKKAILTESENKLR 556
Query: 134 -LKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDN-----VKKLQEEI 187
L+ E R++ E +++L+K L+E N +L+ L+ + N + V+K + E+
Sbjct: 557 DLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTEL 616
Query: 188 EKIRPG----FEEQILYLQKQLDATTDEKKETVTQ-LQNIIEANSQHYQKNINSLQEELL 242
E ++ + E++ L++Q ++ +E Q + +++ +Q +I + E+ L
Sbjct: 617 ESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTL 676
Query: 243 QLKAIHQEEVKELMCQIEASAKEH---EAEINKLNELKENLVKQCEASEKNIQKKYECEL 299
+ + Q E++ L ++ K E E++ L + + + ++ EA + ++ ++
Sbjct: 677 EKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
Query: 300 ENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMN 359
+++ K + Q + L + +E ++ E+ KHL++ +E+ + +K +
Sbjct: 737 DSIIKEHEVSIQRTE--KALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQ 794
Query: 360 NLKLKLEM--DAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCY 417
KL++ Q E E+ ++ + LL E + ++ K +E+ K C
Sbjct: 795 QASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCT 854
Query: 418 TVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQ---GLKEQCENLQ--QE 472
++ H +VQ L +Q +K+ SE+ + S LT ++E + G KEQ + Q E
Sbjct: 855 ELDAHKIQVQDLMQQLEKQNSEMEQKVKS------LTQVYESKLEDGNKEQEQTKQILVE 908
Query: 473 KQEAILNY-ESLREIMEILQTELG---ESAGKISQEFESMKQQQASDVHELQQKLRTAFT 528
K+ IL E ++ +EIL +L +S +++E+E+ + Q + +++QK +
Sbjct: 909 KENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKE--- 965
Query: 529 EKDALLETVNRLQGENEKLLSQQ-ELVPELENTIKNLQEKNGVY---LLSLSQRDTM--- 581
+ ET+ + KLL Q+ +L ELENT L +K + +L ++Q ++
Sbjct: 966 ----MQETLKK------KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGIS 1015
Query: 582 --LKELEG----KINSLTE----EKDDFIN----KLKNSHEEMDNFHK-KCEREERLILE 626
+ LE +I SLTE E +D I+ KL EE+ H+ + + +E+ + E
Sbjct: 1016 DAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAE 1075
Query: 627 LGKKVEQTIQYNSELEQKVNELTGGLEETLKEK---DQNDQKLEKLMVQMKVLSEDKEVL 683
L +K+ + + E E+ E+T EE +K+ ++ ++L++ + L++D+ L
Sbjct: 1076 LKQKI---LLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKL 1132
Query: 684 SAEVKSLYEENNKLSSEKKQLSRDL-EVFLSQKEDVILKEHITQLEKKLQLMVEEQDNL- 741
A ++ L + NK E L L E+ + +ED K +++L KL+ EE +L
Sbjct: 1133 KAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEED---KRKVSELTSKLKTTDEEFQSLK 1189
Query: 742 ------NKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEE--KDVVNVLQAVGESLAKI 793
NK LE++ ++ K++ E++ + K +L+A L I
Sbjct: 1190 SSHEKSNKSLEDKSLE-----------FKKLSEELAIQLDICCKKTEALLEAKTNELINI 1238
Query: 794 NEEKCNLAFQRDEK------------------VLELEKEIKCLQEE----------SVVQ 825
+ K N R V ELE +++ L EE + Q
Sbjct: 1239 SSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQ 1298
Query: 826 CEE----LKSLLRDYEQ---EKVLLRKE---LEEIQSEKEA----LQSDLLE-------M 864
EE +KS+ D E EK L+KE ++ SEKE+ L+ +L E M
Sbjct: 1299 LEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLM 1358
Query: 865 KNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAE 924
K ++ ++E +L Q+ +++ S +EKE + E+ EL D+ +
Sbjct: 1359 KEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDE--EKCELLDQVQD 1416
Query: 925 LILLKDSLAK----------------------SPSVKNDPLSSVKELEEKIENLEKECKE 962
L D+L+K + S ++VKEL+ ++E KE E
Sbjct: 1417 LSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYE 1476
Query: 963 KEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQG------- 1015
K+E+IN + K+ELD K +K E+E +S+ ++ +++ ++
Sbjct: 1477 KDEQINLL-------KEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIME 1529
Query: 1016 -----------AESYKNLLLEYEKQS--------------EQLDVEKE-RANNFEHRIED 1049
ES +L Y +Q ++L EK+ R E +I
Sbjct: 1530 LEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILT 1589
Query: 1050 LTRQLRNSTLQCET-----------INSDNEDLLARIETLQSN--AKLLEVQILEVQRAK 1096
L Q+ + + ET + S E+L A + L+S AKL E++ + ++
Sbjct: 1590 LENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELK-RKAEQKI 1648
Query: 1097 AMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTT 1156
A + K+L ++ +KE++ K+ T + L EL +LQ+ ++++ ++L+ V+ +T
Sbjct: 1649 AAIKKQLLSQMEEKEEQYKK--GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL 1706
Query: 1157 LM---NMEIADYERLMKELNQKLTNK--NNKIEDLEQEIKIQKQKQETLQEEITSLQSSV 1211
++ +A Y + +Q K KI L++ + +K++ LQ + +V
Sbjct: 1707 IVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNL---TEKEKLLQRVGQEKEETV 1763
Query: 1212 QQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEIT 1271
+ E + ++ L+K E A++KQ E +I L+ ELE ++ + Q E
Sbjct: 1764 SSHFEMRCQYQERLIKL--EHAEAKQHEDQSMI--GHLQEELEEKNKKYSLIVAQHVEKE 1819
Query: 1272 SEKHKIH---------EHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFES 1322
K+ I + ++ + ++ + T +Q++ L + C + E V E +
Sbjct: 1820 GGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKEL-DSCLVRQKEVHRVEMEELT 1878
Query: 1323 YKVRVHNVLKQQ--KNKSMSQAETEGAKQEREHL---------EMLIDQLKIKLQDSQNN 1371
K L+Q +NK E ++ + HL E + L+ KL ++
Sbjct: 1879 SKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAERE 1938
Query: 1372 LQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQ 1431
Q E+ LQ + L + H + L E + KE + +E+ I+ E ++ +H T+ Q
Sbjct: 1939 KQKLGKEIVRLQKDLRMLRKEHQQEL-EILKKEYD-QEREEKIKQEQEDLELKHNSTLKQ 1996
Query: 1432 LTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSL 1491
L + F Q+ ++E T++ + ++EA+L + E T Q L
Sbjct: 1997 LMRE-------FNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEET-------NQLL 2042
Query: 1492 KNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPP- 1550
K + E+ + D+ + E ++ + E + LE+L + KLE
Sbjct: 2043 KKIAEKDD------DLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEE 2096
Query: 1551 -LWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQER 1609
+ T EL +L+ T L+ +++ EQI L+ +++ E+N
Sbjct: 2097 NPGNDNVTIMELQTQLAQKTT-------LISDSKLKEQEFREQIHNLEDRLKKYEKNVYA 2149
Query: 1610 EK-------------------SAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSP 1650
EYL+ VL +++ G E + + VI T+L+
Sbjct: 2150 TTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVLFEYMM---GRETKTMAKVITTVLKFPD 2206
Query: 1651 EEKGKL 1656
++ K+
Sbjct: 2207 DQTQKI 2212
Score = 236 bits (602), Expect = 1e-61
Identities = 367/1750 (20%), Positives = 760/1750 (43%), Gaps = 260/1750 (14%)
Query: 41 IQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENI 100
I + +SR ++ + EELR + K +ER LEKA + Q ++
Sbjct: 384 IAQLRSRIKQMTTQGEELREQ----------KEKSERAAFEELEKALSTAQ--KTEEARR 431
Query: 101 KMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDK-ANLQKQLEEA 159
K+K E+++ + + K E+ I+ +E+ +K E++ V K SE++ A LQK E+
Sbjct: 432 KLKAEMDEQIKTI---EKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKE 488
Query: 160 MNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQL 219
+ ++ KKLQ + + + + Q + + EK++ +
Sbjct: 489 L------------ARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA 536
Query: 220 QNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKEN 279
+E + + +L Q ++ + EL +E S +E++ N+ +L +
Sbjct: 537 LEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENK---NQSKDLAVH 593
Query: 280 LVKQCEASEKNIQ---KKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKH 336
L + K I +K++ ELE+L K +A ++ + Q T +E+ + EK +
Sbjct: 594 LEAEKNKHNKEITVMVEKHKTELESL-KHQQDALWTEKLQVLKQQYQTEMEK-LREKCEQ 651
Query: 337 LEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEE 396
++TL L+ + I + + MN L+ ++D + E E L +++E+L A+
Sbjct: 652 EKETL--LKDKEIIFQAHIEEMNEKTLE-KLDVKQT------ELESLSSELSEVLKAR-- 700
Query: 397 QGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLM 456
KL+ EL+ L Q ++ ++ K HQ+++ + + ++ + L
Sbjct: 701 -----HKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALK 755
Query: 457 FEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKIS--QEFESMKQQQAS 514
+I L+ + + +E + E+L ++ + EL +++ K+ Q ++S +Q
Sbjct: 756 DQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTK 815
Query: 515 DVHE----LQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVP-ELENTIKNLQEKNG 569
E LQQKL TE+ L + V ++ + + + ++ + ++++ ++ L+++N
Sbjct: 816 AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQN- 874
Query: 570 VYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILEL-- 627
E+E K+ SLT+ + +KL++ ++E + + +E +IL++
Sbjct: 875 -------------SEMEQKVKSLTQV---YESKLEDGNKEQEQTKQILVEKENMILQMRE 918
Query: 628 --GKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSE--DKEVL 683
K++E Q S E ++ L E K + ++K+EK+ + K + E K++L
Sbjct: 919 GQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQ---EKKMEKVKQKAKEMQETLKKKLL 975
Query: 684 SAEVKSLYEENN---KLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDN 740
E K E N +LS ++KQ + + + ++Q + + +++LE + +E
Sbjct: 976 DQEAKLKKELENTALELSQKEKQFNAKM-LEMAQANSAGISDAVSRLETNQKEQIESLTE 1034
Query: 741 LNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNL 800
+++ N+ + K L + E+ E E + LQ + +A++ ++
Sbjct: 1035 VHRRELNDVISIWEKK------LNQQAEELQEIHEIQ-----LQEKEQEVAELKQKILLF 1083
Query: 801 AFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKV---LLRKELEEIQSEKEAL 857
+++ E+ KEI L+EE V Q L L +Q+ L ++ ++++ E L
Sbjct: 1084 GCEKE----EMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKL 1139
Query: 858 QSDLLEMKNANEKTRLENQNLLIQV------EEVSQTCSKSEIHNEKEKCFIKEHENLKP 911
+ DL K+ E T L+ Q + +++ +VS+ SK + +E+ + HE
Sbjct: 1140 EVDL--NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNK 1197
Query: 912 LLEQKELRDRR--AELILLKDSLAK----------------SPSVKNDPLSSVKELEEK- 952
LE K L ++ EL + D K S S N LS + + +
Sbjct: 1198 SLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRT 1257
Query: 953 -------------IENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLR 999
+ LE + ++ E+ N + + +A +L+ + +++K ++ESL
Sbjct: 1258 TKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLV 1317
Query: 1000 SEKDQLSASMRDLIQGAESYKNLLLEYEKQ-----------SEQLDVEKERANNFEHRIE 1048
+EK+ L + Q A ++ + + +K+ E+L +K ++ ++
Sbjct: 1318 TEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT 1377
Query: 1049 DLTRQLRNSTLQCE---TINS-----DNE--DLLARIETLQSNAKLLEVQILEVQRAKAM 1098
DL QL+NS E I+S D E +LL +++ L L + +
Sbjct: 1378 DLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDD 1437
Query: 1099 VDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLM 1158
+ K + + + +H TV +ELQ+QL+ + K+ + +++ L+K++ Q
Sbjct: 1438 WSNKFSEWKKKAQSRFTQHQNTV---KELQIQLELKSKEAYEKDEQINLLKEELDQ---- 1490
Query: 1159 NMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEIT-------SLQSSV 1211
+ ++ L E+ + K +LE E+K Q + L++ IT SL +
Sbjct: 1491 --QNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVL 1548
Query: 1212 QQY-EEKNTKIKQLLVKTK--KELADS-----KQAETDHLILQ---ASLKGELEASQQQV 1260
+ Y ++K+ + K+L+ K + +EL + K+AE L L+ S+K ELE ++++
Sbjct: 1549 KNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKEL 1608
Query: 1261 EVYKIQLAEITSEKHKIHEHLKT-SAEQHQRTLSAYQQRVTALQEEC------------R 1307
E + + E + + L++ SA + +Q++ A++++ +
Sbjct: 1609 EHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKK 1668
Query: 1308 AAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQD 1367
++ + + ++ + + VH + ++ K+ SQ+ET + +++ +Q + Q
Sbjct: 1669 GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQG 1728
Query: 1368 S-QNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHT 1426
Q + +S LQ +E + LL+R + +ETVS E+R Q + ++K EH
Sbjct: 1729 CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMR-----CQYQERLIKLEHA 1783
Query: 1427 QTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVS 1486
E ++ + + HLQEE L+++ K + Q + ++ +
Sbjct: 1784 ----------EAKQHEDQSMIGHLQEE-------LEEKNKKYSLIVAQHVEKEGGKNNIQ 1826
Query: 1487 SQQSLKN--------LRERRNT------DLPLLDMHTVTREEGEGMETTDTESVSSASTY 1532
++Q+L+N L+E+ T + LD V ++E + + E ++S
Sbjct: 1827 AKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKE---VHRVEMEELTSKYEK 1883
Query: 1533 TQSLEQL--LNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADH--LNGLLRETEATNAI 1588
Q+L+Q+ N P LE E +K LVQ + A H L L E
Sbjct: 1884 LQALQQMDGRNKPTELLEENT--EEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQK 1941
Query: 1589 LMEQIKLLKSEIRRLERNQEREKSAANLEYLK------NVLLQFIFLKPGSERERLLPVI 1642
L ++I L+ ++R L + ++E EY + + + LK S ++L+
Sbjct: 1942 LGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREF 2001
Query: 1643 NTMLQLSPEE 1652
NT L +E
Sbjct: 2002 NTQLAQKEQE 2011
Score = 166 bits (419), Expect = 2e-40
Identities = 257/1274 (20%), Positives = 547/1274 (42%), Gaps = 175/1274 (13%)
Query: 486 IMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENE 545
+ + ++ + ES + S + ++ ++ L TA + + +++ N
Sbjct: 72 VESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNS 131
Query: 546 KLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKN 605
L++++L+ L ++L G Y ++ + +E + L++ +D + ++
Sbjct: 132 DSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAE 191
Query: 606 SHEE--MDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLE------ETLK 657
EE MD KK +E E +E+ QY S L+ +V+ L L + LK
Sbjct: 192 LREELQMDQQAKKHLQE-----EFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLK 246
Query: 658 EKDQNDQKLEKLMVQMKVLSEDKEVL--SAEVKSLYEENNKLSSEKKQLSRDLEVFLSQK 715
Q + + E + S+ + V+ VK+L ++ ++ L R E S K
Sbjct: 247 PLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHK 306
Query: 716 EDVI------------LKEHITQLEK--------KLQLMVEEQDNLNKLLENEQVQKLFV 755
E L E + +LEK K +L+ + +D N + + EQ + + +
Sbjct: 307 EQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVI 366
Query: 756 ---KTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLE-L 811
K Q++ L EM E E ++ + + + GE L + E+ AF+ EK L
Sbjct: 367 AETKRQMHETL-EMKEE--EIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTA 423
Query: 812 EKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE-----KEALQSDLLEMKN 866
+K + ++ E++K++ + E+E++ L++EL ++ E K++ + + +++
Sbjct: 424 QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK 483
Query: 867 ANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRA--E 924
+EK + L + + + E + + K + ++KE ++ A E
Sbjct: 484 LHEKELARKEQELTKKLQTRE----REFQEQMKVALEKSQSEYLKISQEKEQQESLALEE 539
Query: 925 LILLKDS-LAKSPSVKNDPLSSVKELEEKIENLEKEC-KEKEEKINKIKLVAVKAKKELD 982
L L K + L +S + D + +I LE K +E N+ K +AV + E +
Sbjct: 540 LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
Query: 983 SSRKETQTV----KEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKE 1038
KE + K ELESL+ ++D L +++ + Y+ E EK E+ + EKE
Sbjct: 600 KHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLK--QQYQT---EMEKLREKCEQEKE 654
Query: 1039 -----RANNFEHRIEDLT----RQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQI 1089
+ F+ IE++ +L + E+++S+ ++L L+ +L+ Q
Sbjct: 655 TLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQT 714
Query: 1090 LEV-QRAKAMVDKELEAEKLQKEQKIKEHATTV--------NELEELQVQLQKEKKQLQK 1140
++ Q +A +D++ + Q + IKEH ++ +++ +L++ L++ K L++
Sbjct: 715 DKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE 774
Query: 1141 TMQELELVKKDAQQT------------------TLMNMEIADYERLMKELNQKLTN-KNN 1181
+E ++ D +++ + + + YE + +L QKL + +
Sbjct: 775 HQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE 834
Query: 1182 KIEDLEQEIKIQKQKQET---LQEEITSLQSSVQQYEEKNTKIKQ------LLVKTKKEL 1232
+I +Q +++ QK++ L +Q +QQ E++N++++Q + ++K E
Sbjct: 835 RILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894
Query: 1233 ADSKQAETDHLILQAS--LKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQR 1290
+ +Q +T ++++ + E ++++E+ +L+ H ++E +T + ++
Sbjct: 895 GNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEK 954
Query: 1291 TLSAYQQRVTALQEECRAAKAEQ-ATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGA-- 1347
+ +Q+ +QE + +Q A + E E+ + + KQ K + A+ A
Sbjct: 955 KMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGI 1014
Query: 1348 --------KQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQE 1399
++E +E L + + +L D I++ E + L + + L E H LQE
Sbjct: 1015 SDAVSRLETNQKEQIESLTEVHRRELND-----VISIWE-KKLNQQAEELQEIHEIQLQE 1068
Query: 1400 TVSKEAELREKLCSIQSENMMMKSEHT----QTVSQLTSQNEVLRNSFRDQVRHL----- 1450
+ AEL++K+ E M E T + V Q T+ NE L+ + + H+
Sbjct: 1069 KEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNE-LQEQLKQKSAHVNSLAQ 1127
Query: 1451 -QEEHRKTVETLQQQLSK-------MEAQLFQLK----------NEPTTRSPVSSQ--QS 1490
+ + + +E L+ L+K ++ QL +LK +E T++ + + QS
Sbjct: 1128 DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQS 1187
Query: 1491 LKNLRERRNTDLP-------------LLDMHTVTREEGEGMETTDTESVSSASTYTQSLE 1537
LK+ E+ N L + + ++ +E E ++ +S+ T ++
Sbjct: 1188 LKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAIL 1247
Query: 1538 QLLNSPE---TKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIK 1594
++ + TK++ L T EL +L T+ + LN ++ QIK
Sbjct: 1248 SRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIK 1307
Query: 1595 LLKSEIRRLERNQE 1608
+K++I L +E
Sbjct: 1308 SMKADIESLVTEKE 1321
Score = 134 bits (337), Expect = 7e-31
Identities = 251/1191 (21%), Positives = 499/1191 (41%), Gaps = 224/1191 (18%)
Query: 639 SELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLS 698
+ + + + T L+E ++ D + +Q++V S + S +SL+ ++K S
Sbjct: 33 TRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKES 92
Query: 699 ----SEKKQLSR-DLEVFL----------SQKEDVI----------LKEHITQLEKKL-- 731
S ++ L+R DL+ S+ ED++ L + + ++E+ L
Sbjct: 93 LVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSS 152
Query: 732 ------------QLMVEEQDNLNKLLENEQVQKLFVKTQLYGFL-------KEMGSEVSE 772
Q++ E+ L +L Q + L +L L K + E
Sbjct: 153 YRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDA 212
Query: 773 DSEEKD-VVNVLQA-VGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQE------ESVV 824
EEKD ++VLQ V ++ N+ + LE + E+ +E E VV
Sbjct: 213 SLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVV 272
Query: 825 Q----CEELKSLLRDYEQEKVLLRKELEEIQ----------SEKEALQSDLLE------- 863
+ + L++L + ++++ LL++ E IQ SEKEALQ L E
Sbjct: 273 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEK 332
Query: 864 MKNAN--EKTRLENQ-----NLLIQVEE-----VSQTCSKSEIHNE---KEKCFIKEHEN 908
+K+ + EKT+L Q NL+ Q+E+ +++T K ++H KE+ +
Sbjct: 333 IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAET--KRQMHETLEMKEEEIAQLRSR 390
Query: 909 LKPLLEQ-KELRDR-----RAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKE 962
+K + Q +ELR++ RA L+ +L+ + + E++E+I+ +EK +E
Sbjct: 391 IKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE 450
Query: 963 K----EEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAES 1018
+ +++++++K V K+ S + + K + L ++ +L+ ++ + +
Sbjct: 451 ERISLQQELSRVKQEVVDVMKK-SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQE 509
Query: 1019 YKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQ----LRNSTLQCETINSDNEDLLAR 1074
+ LE + QSE L + +E+ +E+L Q L S + + + E R
Sbjct: 510 QMKVALE-KSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR 568
Query: 1075 IETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKI----KEHATTVNELEELQVQ 1130
I L+S+ LE + E + + LEAEK + ++I ++H T + L+ Q
Sbjct: 569 ILELESS---LEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDA 625
Query: 1131 LQKEKKQLQKTMQELELVK-----KDAQQTTLMNMEI---ADYERLMKELNQKLTNKNNK 1182
L EK Q+ K + E+ K + ++T L + EI A E + ++ +KL K +
Sbjct: 626 LWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTE 685
Query: 1183 IEDLEQEIKIQKQKQETLQEEITSLQSSVQQY---------EEKNTKIKQL--------- 1224
+E L E+ + + L+EE++ L+ + E+KN +Q+
Sbjct: 686 LESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEV 745
Query: 1225 -LVKTKKELADS-KQAE----------TDHLILQASLKGELEASQQQVEVYKIQLAEITS 1272
+ +T+K L D Q E +H +L+ +++ S+ +++ +L S
Sbjct: 746 SIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQS 805
Query: 1273 EKHKIHEHLKTSAEQ----HQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVH 1328
+ HE K EQ Q+ L +R+ L ++ +A++ V +E +++K++V
Sbjct: 806 YQSATHEQTKAYEEQLAQLQQKLLDLETERI-LLTKQVAEVEAQKKDVCTELDAHKIQVQ 864
Query: 1329 NVLKQ---------QKNKSMSQAE----TEGAKQEREHLEMLIDQLKIKLQDSQ------ 1369
++++Q QK KS++Q +G K++ + ++L+++ + LQ +
Sbjct: 865 DLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEI 924
Query: 1370 ----NNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKL-CSIQSENMMMKSE 1424
L + L E++T + K +++ K E++E L + + +K E
Sbjct: 925 EILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKE 984
Query: 1425 HTQTVSQLTSQNEV----------------------LRNSFRDQVRHLQEEHRKTVETLQ 1462
T +L+ + + L + ++Q+ L E HR+ L
Sbjct: 985 LENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRR---ELN 1041
Query: 1463 QQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDL-------PLLDMHTVTREEG 1515
+S E +L Q E + Q+ + + E + L + T +EEG
Sbjct: 1042 DVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEG 1101
Query: 1516 EGMETTDT---ESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSA 1572
+TT E + S + SL Q ETKL+ L E + +++ + +
Sbjct: 1102 VKQDTTLNELQEQLKQKSAHVNSLAQ----DETKLKAHLEKLEVDLNKSLKENTFLQEQL 1157
Query: 1573 DHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSA---ANLEYLK 1620
L L E + + L ++K E + L+ + E+ + +LE+ K
Sbjct: 1158 VELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKK 1208
Score = 125 bits (314), Expect = 3e-28
Identities = 232/1089 (21%), Positives = 446/1089 (40%), Gaps = 178/1089 (16%)
Query: 696 KLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFV 755
K+S E++QL + L + T++ + E+ D E+ Q
Sbjct: 8 KISEEQQQLQQALAPAQASSNS----STPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQ 63
Query: 756 KTQLYG------FLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQ----RD 805
K QL F + + S ++ +V ESL +++ + +F D
Sbjct: 64 KLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSR--ESLNRLDLDSSTASFDPPSDMD 121
Query: 806 EKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMK 865
+ +L L +E ++Q LR E+ R + E+ + + LQ + +++
Sbjct: 122 SEAEDLVGNSDSLNKEQLIQ------RLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQ 175
Query: 866 NANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKE--LRDRRA 923
+++ ++ + ++ E Q +++ H ++E LE+K+ + +
Sbjct: 176 GILSQSQDKSLRRIAELREELQMDQQAKKHLQEE---------FDASLEEKDQYISVLQT 226
Query: 924 ELILLKDSLAKSPSVKNDPLSSVKELEE------KIENLEKECKEKEEKINKIKLVA--- 974
++ LLK L P + D L + +LE K EN E + + E +K +
Sbjct: 227 QVSLLKQRLRNGP-MNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQ 285
Query: 975 --VKAKKELDSSRKET-QTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSE 1031
VK ++ L KET Q+ KE+ L SEK+ L + + +Q E K+L +
Sbjct: 286 QRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHM------- 338
Query: 1032 QLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILE 1091
EK + L QLR++ E + D ++A ET + + LE++ E
Sbjct: 339 ---AEKTK----------LITQLRDAKNLIEQLEQDKGMVIA--ETKRQMHETLEMKEEE 383
Query: 1092 VQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKD 1151
+ + ++ + + + +EQK K ELE+ QK ++ +K E++ K
Sbjct: 384 IAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKT 443
Query: 1152 AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDL------EQEIKIQKQKQETL----Q 1201
++T ++ ER+ L Q+L+ ++ D+ EQ K+QK ++ L Q
Sbjct: 444 IEKT-------SEEERI--SLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ 494
Query: 1202 EEITSLQSSVQQYEE------KNTKIKQLLVKTKKELADSKQAETDHLILQASL---KGE 1252
E LQ+ ++++E + ++ + L + +KE +S E L +A L + +
Sbjct: 495 ELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENK 554
Query: 1253 LEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSA----YQQRVTALQEECRA 1308
L QQ+ E Y+ ++ E+ S K + K ++ L A + + +T + E+
Sbjct: 555 LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEK--- 611
Query: 1309 AKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHL---EMLIDQLKIKL 1365
K E ++ + ++ VLKQQ M + E +QE+E L + +I Q I+
Sbjct: 612 HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR-EKCEQEKETLLKDKEIIFQAHIEE 670
Query: 1366 QDSQ--NNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS 1423
+ + L + +EL++L SE +L+ +K+ +E + + + ++++ K+
Sbjct: 671 MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN 730
Query: 1424 EHTQTVSQLTSQNEV----LRNSFRDQVRHLQ----------EEHRKTVETLQQQLSKME 1469
H Q V + ++EV + +DQ+ L+ +EH+ VE L+ + + E
Sbjct: 731 HHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSE 790
Query: 1470 AQL---------FQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHT----------- 1509
+L FQ T + ++ L L+++ LLD+ T
Sbjct: 791 GELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK------LLDLETERILLTKQVAE 844
Query: 1510 VTREEGEGMETTDTESV----------SSASTYTQSLEQLLNSPETKLEPPLWHAEFTKE 1559
V ++ + D + S Q ++ L E+KLE E TK+
Sbjct: 845 VEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQ 904
Query: 1560 ELVQKLSSTTKSADHLNGLLRETEATNAILM---EQIKLLKSEIRRLERNQE------RE 1610
LV+K + + + G +E E L + I +L E +NQE ++
Sbjct: 905 ILVEKENMILQMRE---GQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQ 961
Query: 1611 KSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRS 1670
K+ E LK LL E + + NT L+LS +EK A + + + N++
Sbjct: 962 KAKEMQETLKKKLLD-------QEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGI 1014
Query: 1671 SGWASYLHS 1679
S S L +
Sbjct: 1015 SDAVSRLET 1023
>gi|83267877 RANBP2-like and GRIP domain containing 5 isoform 1 [Homo
sapiens]
Length = 1765
Score = 241 bits (616), Expect = 3e-63
Identities = 162/333 (48%), Positives = 200/333 (60%), Gaps = 33/333 (9%)
Query: 1361 LKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMM 1420
++ KLQD ++ + E +T Q E D+L+ H VS+ + RE C + ++
Sbjct: 1445 VRFKLQDVADSFKKIFDEAKTAQ-EKDSLITPH-------VSRSSTPRESPCGKIAVAIL 1496
Query: 1421 MKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTV----------ETLQQQLSKMEA 1470
E T+ + + ++V + +V E K V E++++ S ++
Sbjct: 1497 --EETTRERTDVIQGDDVADAASEVEVSSTSETTTKAVVSPPKFVFVSESVKRIFSSEKS 1554
Query: 1471 QLFQLKNEPTTRS--PVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSS 1528
+ F N T S S LK+ ++ V ++ E + +D E S
Sbjct: 1555 KPFVFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELSKNSDIEQSSD 1614
Query: 1529 AS---------TYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLL 1579
+ T S+ +PE EPPLWHAEFTKEELVQKL STTKSADHLNGLL
Sbjct: 1615 SKVKNLSASFPTEESSINYTFKTPEK--EPPLWHAEFTKEELVQKLRSTTKSADHLNGLL 1672
Query: 1580 RETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLL 1639
RE EATNA+LMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLL
Sbjct: 1673 REIEATNAVLMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLL 1732
Query: 1640 PVINTMLQLSPEEKGKLAAVAQGEEENASRSSG 1672
PVINTMLQLSPEEKGKLAAVAQ EEENASRSSG
Sbjct: 1733 PVINTMLQLSPEEKGKLAAVAQDEEENASRSSG 1765
>gi|182765478 RANBP2-like and GRIP domain containing 6 [Homo sapiens]
Length = 1765
Score = 241 bits (616), Expect = 3e-63
Identities = 162/333 (48%), Positives = 200/333 (60%), Gaps = 33/333 (9%)
Query: 1361 LKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMM 1420
++ KLQD ++ + E +T Q E D+L+ H VS+ + RE C + ++
Sbjct: 1445 VRFKLQDVADSFKKIFDEAKTAQ-EKDSLITPH-------VSRSSTPRESPCGKIAVAIL 1496
Query: 1421 MKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTV----------ETLQQQLSKMEA 1470
E T+ + + ++V + +V E K V E++++ S ++
Sbjct: 1497 --EETTRERTDVIQGDDVADAASEVEVSSTSETTTKAVVSPPKFVFVSESVKRIFSSEKS 1554
Query: 1471 QLFQLKNEPTTRS--PVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSS 1528
+ F N T S S LK+ ++ V ++ E + +D E S
Sbjct: 1555 KPFVFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELSKNSDIEQSSD 1614
Query: 1529 AS---------TYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLL 1579
+ T S+ +PE EPPLWHAEFTKEELVQKL STTKSADHLNGLL
Sbjct: 1615 SKVKNLSASFPTEESSINYTFKTPEK--EPPLWHAEFTKEELVQKLRSTTKSADHLNGLL 1672
Query: 1580 RETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLL 1639
RE EATNA+LMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLL
Sbjct: 1673 REIEATNAVLMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLL 1732
Query: 1640 PVINTMLQLSPEEKGKLAAVAQGEEENASRSSG 1672
PVINTMLQLSPEEKGKLAAVAQ EEENASRSSG
Sbjct: 1733 PVINTMLQLSPEEKGKLAAVAQDEEENASRSSG 1765
>gi|169162953 PREDICTED: RANBP2-like and GRIP domain containing 8
[Homo sapiens]
Length = 1765
Score = 239 bits (611), Expect = 1e-62
Identities = 161/333 (48%), Positives = 199/333 (59%), Gaps = 33/333 (9%)
Query: 1361 LKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMM 1420
++ KLQD ++ + E +T Q E D+L+ H VS+ + RE C + ++
Sbjct: 1445 VRFKLQDVADSFKKIFDEAKTAQ-EKDSLITPH-------VSRSSTPRESPCGKIAVAVL 1496
Query: 1421 MKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTV----------ETLQQQLSKMEA 1470
E T+ + + ++V + +V E K V E++++ S ++
Sbjct: 1497 --EEITRERTDVIQGDDVADAASEVEVSSTSETTTKAVVSPPKFVFVSESVKRIFSSEKS 1554
Query: 1471 QLFQLKNEPTTRS--PVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSS 1528
+ F N T S S LK+ ++ V ++ E + +D E S
Sbjct: 1555 KPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELSKNSDIEQSSD 1614
Query: 1529 AS---------TYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLL 1579
+ T S+ +PE EPPLWHAEFTKEELVQKL STTKSADHLNGLL
Sbjct: 1615 SKVKNLSASFPTEESSINYTFKTPEK--EPPLWHAEFTKEELVQKLRSTTKSADHLNGLL 1672
Query: 1580 RETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLL 1639
RE EATNA+LMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLL
Sbjct: 1673 REIEATNAVLMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLL 1732
Query: 1640 PVINTMLQLSPEEKGKLAAVAQGEEENASRSSG 1672
PVINTMLQLSPEEKGKLAAVAQ EEEN SRSSG
Sbjct: 1733 PVINTMLQLSPEEKGKLAAVAQDEEENPSRSSG 1765
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 230 bits (587), Expect = 8e-60
Identities = 357/1660 (21%), Positives = 715/1660 (43%), Gaps = 273/1660 (16%)
Query: 35 KKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLS 94
+++++L+ + KS +E+E+ +E++ K + + +T D L E E +
Sbjct: 740 REEVILLSELKSLPSEVERLRKEIQDK------SEELHIITSEKDKLFSEVVHKESRVQG 793
Query: 95 LKKENIKMKQEV------------------------EDSVTKMGDAHKELEQSHINYVKE 130
L +E K K ++ E + + ++ + Q +N KE
Sbjct: 794 LLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKE 853
Query: 131 IENLKNELMAVRSKYSEDKANLQ---KQLEEAMNTQLELSEQLKFQNNSEDNVK------ 181
+ + L A++++ S LQ ++++E +N +L EQL+ ++++ V+
Sbjct: 854 AQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLI 913
Query: 182 --KLQEEIEKIRPGFEEQ--ILYLQKQLDATTDEKK-----------ETVTQLQNIIEAN 226
KLQ+ +E+++ +E+ + LQ+ L D+ K +T QL+N +E+
Sbjct: 914 TEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESL 973
Query: 227 SQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEA 286
QH Q+ IN+L+ ++ EEV + E + + + E ++ +V
Sbjct: 974 KQH-QETINTLKSKI-------SEEVSRNLHMEENTGETKD-------EFQQKMV----- 1013
Query: 287 SEKNIQKKYECELENLRKATSNANQDNQICSILLQENTF-VEQVVNEKVKHLEDTLKELE 345
I KK + E +N + T++ +DN+I I Q F + Q NE + LE + E E
Sbjct: 1014 ---GIDKKQDLEAKNTQTLTADV-KDNEI--IEQQRKIFSLIQEKNELQQMLESVIAEKE 1067
Query: 346 SQHSILKD--EVTYMNNLKLKLEMDAQHIKDEFF-HEREDLEFKINELLLAKEEQGCVIE 402
+ LK+ E+T N +L+L D + E E+ K EL + V E
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127
Query: 403 KLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELN---------ETFLSDSEKEKL 453
KLK + L ++ +Q VQ + QK+I+E+ E L E E+L
Sbjct: 1128 KLKEKSQQLQEK-----QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERL 1182
Query: 454 TLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQ----EFESMK 509
L ++ E+ +++ +E++ L+E+ + +TE G I + ++ +
Sbjct: 1183 ELAQKLNENYEEVKSITKERKV-------LKELQKSFETERDHLRGYIREIEATGLQTKE 1235
Query: 510 QQQASDVH-----ELQQKLRTAFTEKDA-------LLETVNRLQGENEKLLSQQELVPEL 557
+ + + +H E +LR + +EK A L ++ +LQ E L +QEL+P +
Sbjct: 1236 ELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV 1295
Query: 558 ENTIKNLQEKNGVYLL---SLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFH 614
+ + + N + LL S ++ T L +E + L E K + S EE+ +
Sbjct: 1296 KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNE-------KFQESQEEIKSLT 1348
Query: 615 KKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETL--KEKDQNDQKLEKLMVQ 672
K+ + + + L K +Q ++ E K+ E E++L KEKD K+ M Q
Sbjct: 1349 KERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ 1408
Query: 673 MKVLSEDKEVLSAEVKSL---------YEENNKLSSEKKQLSRDLEVFLSQKEDVILKEH 723
K +D +L E++ L ++E ++ EK L R EV S+ + LKE+
Sbjct: 1409 FK--PKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQ--LKEN 1464
Query: 724 ITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVL 783
I ++ K L EE+ + EQ + + +L L E +E+S ++ + +N
Sbjct: 1465 IKEIVAK-HLETEEELKVAHCCLKEQEETI---NELRVNLSEKETEISTIQKQLEAIN-- 1518
Query: 784 QAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLL 843
+ + +I E++ ++ +V E E+K +E + L+S+ E + + L
Sbjct: 1519 DKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSI----ESKMLEL 1574
Query: 844 RKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFI 903
L+E Q E + + + EMK E ++E L +E+ +S+ EKE F+
Sbjct: 1575 TNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQ---EKEYQFL 1631
Query: 904 KEHENLKPLLEQKELRDRRAELILLKDSL-AKSPSVKNDPLSSVKELEEKIENLEKECKE 962
K + E +++ E+ LK+ + +++N +++ + ENLE
Sbjct: 1632 K-------MTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLE----- 1679
Query: 963 KEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLI----QGAES 1018
E+ S KE ++ E+L+ E+DQL ++R+ I + E
Sbjct: 1680 -----------------EMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEE 1722
Query: 1019 YKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETL 1078
K + + ++ E +D + + + I ++ + L +S N+ L A+ +
Sbjct: 1723 LKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS----------NDALKAQDLKI 1772
Query: 1079 QSNAKLLEVQILEVQRAKAMVDK--ELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKK 1136
Q ++ + + E Q +DK + +EK K +++ +LE +LQ++ +
Sbjct: 1773 QEELRIAHMHLKEQQET---IDKLRGIVSEKTDKLSNMQK------DLENSNAKLQEKIQ 1823
Query: 1137 QLQKTMQELELVKKDAQQTTLMNMEIADYERLMKEL-NQKLTNKNNKI----------ED 1185
+L+ +L +KKD +T ++++ E+L K++ +Q LT +I E+
Sbjct: 1824 ELKANEHQLITLKKDVNET---QKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHEN 1880
Query: 1186 LEQEIKIQKQK------QETLQEEITSLQSSVQQYEEKNTKIKQ------LLVKTKKELA 1233
LE+ + K++ +ETL+ E L+ S+Q+ + ++ +I+Q +L K KE
Sbjct: 1881 LEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETV 1940
Query: 1234 DSKQAETDHLILQAS--------LKGELEASQQQVEVYKIQLAEITSEKHKIH------E 1279
D + + +Q S K EL+ Q+++ ++QL + + + H E
Sbjct: 1941 DKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEME 2000
Query: 1280 HLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSM 1339
LK E ++ + + L ++ + E V E + + R+ LK ++++ +
Sbjct: 2001 QLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELR-RIKESLKMERDQFI 2059
Query: 1340 SQAETEGAKQEREHL----EMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNK 1395
+ A+ + H + L+ + L +S + EL SE D E N+
Sbjct: 2060 ATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNR 2119
Query: 1396 MLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFR----------D 1445
L + KE E +++L N+ + T+ + +L + N+ F
Sbjct: 2120 -LSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLS 2178
Query: 1446 QVRHLQEEHRKTVETLQQQ-LSKMEAQL-FQLKNEPTTRSPVSSQQSLKNLRERRNTDLP 1503
V ++EE +++ + + ++E Q +K + + + L++L+ +N DL
Sbjct: 2179 YVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLH 2238
Query: 1504 LLD-MHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNS 1542
+ + + + E ++T + +S+ TQ LE+ LN+
Sbjct: 2239 IEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNT 2278
Score = 224 bits (571), Expect = 5e-58
Identities = 340/1715 (19%), Positives = 753/1715 (43%), Gaps = 206/1715 (12%)
Query: 40 LIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKEN 99
L+++ + +L+K++EE+ + + A+ + A LLE+ + Q+ + K EN
Sbjct: 344 LLKRYRKEIMDLKKQLEEVSLETRAQ-------AMEKDQLAQLLEEKDLLQKVQNEKIEN 396
Query: 100 IKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEA 159
+ S+T + + ++ + +I +KN A + + +L +
Sbjct: 397 LTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKL--S 454
Query: 160 MNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQL 219
+N E+ E + +++ N EIE AT +E +
Sbjct: 455 INLLREIDESVCSESDVFSNTLDTLSEIE---------------WNPATKLLNQENIESE 499
Query: 220 QNIIEANSQHYQKNINSL--QEELLQLKAIHQEEVKELMCQIEASAKEHEAE-INKLNEL 276
N + A+ + + L ++E ++LK + ++ E + K+ E + I++++ L
Sbjct: 500 LNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNL 559
Query: 277 KENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVN----E 332
K NLVK E ++++ + ++E LR+ + + EN ++ + E
Sbjct: 560 K-NLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIE 618
Query: 333 KVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLL 392
K ++ TL + E+ K E ++ + L+L+ + + + D++ ++L
Sbjct: 619 DPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEA 678
Query: 393 AKEEQGCVIEKLKS---ELAGLNKQFCYTVEQH---NREVQSLKEQHQKEISELNETFLS 446
K+ Q + ++L+S E+ L V + N E++ QKE+++ E +
Sbjct: 679 KKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNK--EVEEN 736
Query: 447 DSEKEKLTLMFEIQGLKEQCENLQQEKQEA-----ILNYESLREIMEILQTE-----LGE 496
++ +E++ L+ E++ L + E L++E Q+ I+ E + E++ E L E
Sbjct: 737 EALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLE 796
Query: 497 SAGKISQEFESMKQQQASDVHELQ----------QKLRTAFTEKDALLETVNRLQGENEK 546
GK + + + S E Q QK + E + + + + L E +K
Sbjct: 797 EIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQK 856
Query: 547 L-LSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGK----------------- 588
S L EL + LQEK L++ + + ++LE +
Sbjct: 857 FDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEK 916
Query: 589 -------INSLTEEKDDF----------INKLKNSHEEMDNFHKKCEREERLILELGKKV 631
+ +LT+EKDD ++LK+ + N + + + R LE K+
Sbjct: 917 LQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQH 976
Query: 632 EQTIQ-YNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVK-- 688
++TI S++ ++V+ E T + KD+ QK+ + + + +++ + L+A+VK
Sbjct: 977 QETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDN 1036
Query: 689 SLYEENNKLSS---EKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLL 745
+ E+ K+ S EK +L + LE +++KE + T L++ +++ +E Q+ L +LL
Sbjct: 1037 EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQL-----KTDLKENIEMTIENQEEL-RLL 1090
Query: 746 ENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRD 805
+E +K Q +E + ++ E + L V E L +EK ++
Sbjct: 1091 GDE------LKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKL----KEKSQQLQEKQ 1140
Query: 806 EKVLELEKEIKCLQEESVVQCEELKSLLRD-------YEQEKVLLRKELEEIQSEKEALQ 858
+++L +++E+ +Q++ + + E LK+ L++ E E++ L ++L E E +++
Sbjct: 1141 QQLLNVQEEMSEMQKK-INEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT 1199
Query: 859 SDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKEL 918
+ +K + E +L + E+ T +++ + +KEH+ L ++ +
Sbjct: 1200 KERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDEL-RRSV 1258
Query: 919 RDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVK-- 976
++ A++I +D L KS + + + + E +E + N+ KE E +E +N+++L+ +
Sbjct: 1259 SEKTAQIINTQD-LEKSHTKLQEEIPVLHEEQELLPNV-KEVSETQETMNELELLTEQST 1316
Query: 977 -------AKKELDSSR--KETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYE 1027
A+ E++ R ++ Q +EE++SL E+D L L + K + E
Sbjct: 1317 TKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETL 1376
Query: 1028 KQSEQLDVEKERANNFEHRIEDLTR------QLRNSTLQCETINSDNEDLLARIETLQSN 1081
+ ++ ++E++ N + + + T+ Q + I + L R++
Sbjct: 1377 AKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDE 1436
Query: 1082 AKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKT 1141
K + + ++QR + ++ E + K ++ + +H T EL+ L K+ ++T
Sbjct: 1437 MKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCL----KEQEET 1492
Query: 1142 MQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQ 1201
+ EL + + + EI+ ++ ++ +N KL NK +I + E++ I++ + +Q
Sbjct: 1493 INELRVNLSEKE------TEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISE--VQ 1544
Query: 1202 EEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVE 1261
E++ L+ + + K++ ++ + K EL + Q + + + K E++ Q+ ++
Sbjct: 1545 EKVNELKQFKEHRKAKDSALQSIESK-MLELTNRLQESQEEIQIMIKEKEEMKRVQEALQ 1603
Query: 1262 VYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFE 1321
+ + QL E T E I +K S E+ + L ++TA+ E + E + +FE
Sbjct: 1604 IERDQLKENTKE---IVAKMKESQEKEYQFL-----KMTAV-NETQEKMCEIEHLKEQFE 1654
Query: 1322 SYKVRVHNVLKQQKNKSMSQ------AETEGAKQEREHLEMLIDQLKIKLQDSQNNLQIN 1375
+ K+ + N+ + +N ++Q E +ER+ L + + LK++ + NL+
Sbjct: 1655 TQKLNLENI--ETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRET 1712
Query: 1376 VSELQTLQSEHDTLLERHNKMLQETVSK---------------EAELREKLCSIQSENMM 1420
++ + E ++ H K QET+ K + +L +++++++
Sbjct: 1713 ITR-DLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLK 1771
Query: 1421 MKSEHTQTVSQLTSQNEVLR------NSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQ 1474
++ E L Q E + + D++ ++Q++ + LQ+++ +++A Q
Sbjct: 1772 IQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQ 1831
Query: 1475 L----KNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSAS 1530
L K+ T+ VS + LK + ++ L L++ + + + +SV
Sbjct: 1832 LITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKER 1891
Query: 1531 TYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTK-SADHLNGL--LRETEATNA 1587
+ +E+ L +L+ L + E+ Q+L + S +H + LRE +
Sbjct: 1892 DNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKT 1951
Query: 1588 ILMEQIK--LLKSEIRRLERNQEREKSAANLEYLK 1620
I + I+ L KS+ ++ QE +K L +K
Sbjct: 1952 IQISDIQKDLDKSKDELQKKIQELQKKELQLLRVK 1986
Score = 190 bits (483), Expect = 9e-48
Identities = 348/1659 (20%), Positives = 698/1659 (42%), Gaps = 262/1659 (15%)
Query: 32 KFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTER--LDALLLEKAETE 89
+F +K + + +K + +++ + E I + E+ L +L +
Sbjct: 1007 EFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEK 1066
Query: 90 QQCLSLKKENIKMKQEVEDSVTKMGDAHKEL------EQSH-INYVKEIENLKNELMAVR 142
+Q + KENI+M E ++ + +GD K+ E++H I E+ + L V
Sbjct: 1067 EQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVE 1126
Query: 143 SKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQ 202
K E LQ++ ++ +N Q E+SE K N E N+K + E E + L L
Sbjct: 1127 EKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIE-NLKNELKNKELTLEHMETERLELA 1185
Query: 203 KQLDATTDEKK------ETVTQLQNIIEANSQHYQKNINSLQ------EELLQLKAIHQE 250
++L+ +E K + + +LQ E H + I ++ +E L++ IH +
Sbjct: 1186 QKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLK 1245
Query: 251 EVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNAN 310
E +E + ++ S E A+I +L+++ K E E + + + L N+++ +
Sbjct: 1246 EHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQE--EIPVLHEEQELLPNVKEVSETQE 1303
Query: 311 QDNQICSILLQENTFVEQV-----------VNEKVKHLEDTLKELESQHSILKDEVTYMN 359
N++ +L +++T + +NEK + ++ +K L + LK T
Sbjct: 1304 TMNEL-ELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLK---TIKE 1359
Query: 360 NLKLKLEMDAQHIKDEFFHERE---------DLEFKINEL--LLAKEEQ----GCVIEKL 404
L++K + +HI++ +E +++ K NE ++++ EQ + ++
Sbjct: 1360 ALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRI 1419
Query: 405 KSELAGLNKQF------CYTVEQHNREVQSLKEQHQKEISELNETF-------------- 444
+ E+ GL+K+ +V + ++Q L+E Q E +L E
Sbjct: 1420 EIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEEL 1479
Query: 445 --------------------LSDSEKEKLTLMFEIQGLKEQCENLQQE--KQEAILNYES 482
LS+ E E T+ +++ + ++ +N QE ++E N +
Sbjct: 1480 KVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQ 1539
Query: 483 LREIMEILQT-----ELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETV 537
+ E+ E + E ++ Q ES + + + E Q++++ EK+ +
Sbjct: 1540 ISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQ 1599
Query: 538 NRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKD 597
LQ E ++L +E E+ +K QEK +L + T + E + K+ + K+
Sbjct: 1600 EALQIERDQL---KENTKEIVAKMKESQEKEYQFL-----KMTAVNETQEKMCEIEHLKE 1651
Query: 598 DF-INKLKNSHEEMDNFHKKCEREERL--ILELGKKVEQTIQYNSELEQKVNELTGGLEE 654
F KL + E +N E L + + K+ + L+ + ++L L E
Sbjct: 1652 QFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRE 1711
Query: 655 TLKEKDQNDQKLEKLMVQMK-----------VLSEDKEVLSAEVKSLYEENNKLSSEKKQ 703
T+ + ++L+ + + +K ++SE +S K L N+ L ++ +
Sbjct: 1712 TITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLK 1771
Query: 704 LSRDLEV---FLSQKEDVI--LKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKT- 757
+ +L + L ++++ I L+ +++ KL M ++ +N N L+ E++Q+L
Sbjct: 1772 IQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQ-EKIQELKANEH 1830
Query: 758 QLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKC 817
QL K++ + SE + + ++ +L+K+ E NLA + E + E++ +K
Sbjct: 1831 QLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMK- 1889
Query: 818 LQEESVVQCEELKSLLRDYEQEKVLLRKELE-EIQSEKEALQSDLLEMKNANEKTRLENQ 876
+ +++ + EE L RD +E + K + EIQ E + + E K +K R +
Sbjct: 1890 -ERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKIS 1948
Query: 877 NLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKS- 935
IQ+ ++ + KS+ +K+ +++ E LL KE + + I + L K
Sbjct: 1949 EKTIQISDIQKDLDKSKDELQKKIQELQKKE--LQLLRVKEDVNMSHKKINEMEQLKKQF 2006
Query: 936 -------PSVKNDPLSSVKELEEKIENLEKECKEKEE--------KINKIKLVA------ 974
SV+ D K+L E +E + KE++E K+ + + +A
Sbjct: 2007 EAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMI 2066
Query: 975 --------VKAKKEL---------DSSRKETQTVKEELESLRSEKDQLSASMR---DLIQ 1014
VK +K L +S R++ +KE L+ D R DL +
Sbjct: 2067 ARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEK 2126
Query: 1015 GAESYK--------NLLLEY--EKQSEQLDVEKERANNFEHRIEDLTRQLRNSTL----- 1059
E K NL L Y K E+L +R + HRI + + +
Sbjct: 2127 EIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEE 2186
Query: 1060 QCETINS----------DNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQ 1109
Q E+IN ++LL +I+ LQ + +V E++ K + +L E++
Sbjct: 2187 QHESINKFEMDFIDEVEKQKELLIKIQHLQQDC---DVPSRELRDLKLNQNMDLHIEEIL 2243
Query: 1110 KEQKIKEHATTVNELEELQVQLQKEKKQLQK---TMQELELVKKDAQQTTLMNMEIADY- 1165
K+ E + E +++ ++ + L++ T ++E +K Q+ ++ ++
Sbjct: 2244 KDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFF 2303
Query: 1166 -ERLMKELNQKLTNKNNKI---EDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKN--- 1218
R++ +N+ + ++ EQ++K K+K E L + +L++S+ + N
Sbjct: 2304 NNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTT 2363
Query: 1219 ---------TKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAE 1269
++ QL + +EL +S + + + S ++ Q+++EV +A+
Sbjct: 2364 QDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKES---KIIKMQKELEVTNDIIAK 2420
Query: 1270 ITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHN 1329
+ + K+HE K E+ + T+ Q +V AK + E E K+++
Sbjct: 2421 LQA---KVHESNK-CLEKTKETIQVLQDKVAL------GAKPYK----EEIEDLKMKLVK 2466
Query: 1330 V-LKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDT 1388
+ L++ KN + E K E+ + +I L+ L+ SQ +V SEH T
Sbjct: 2467 IDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVI------SEH-T 2519
Query: 1389 LLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVL---RNSFRD 1445
+ NK L K ++SE++ ++ E +S+L QNE L +N
Sbjct: 2520 DPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKE----ISKLKQQNEQLIKQKNELLS 2575
Query: 1446 QVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSP 1484
+HL E V+T +++ K EA Q+ E + +SP
Sbjct: 2576 NNQHLSNE----VKTWKERTLKREAHK-QVTCENSPKSP 2609
Score = 172 bits (435), Expect = 3e-42
Identities = 284/1324 (21%), Positives = 565/1324 (42%), Gaps = 180/1324 (13%)
Query: 23 ETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTE--------GTGDIIKAL 74
ETL K + ++Q + +++ + T++ E+E+ + K G ++
Sbjct: 1374 ETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQES 1433
Query: 75 TERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENL 134
+ + ++ EK + ++ L+ E+ ++K+ +++ V K + +EL+ +H +KE E
Sbjct: 1434 HDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHC-CLKEQEET 1492
Query: 135 KNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRP-- 192
NEL S+ + + +QKQLE A+N +L+ Q ++ + N+K++ E EK+
Sbjct: 1493 INELRVNLSEKETEISTIQKQLE-AINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELK 1551
Query: 193 --------------GFEEQILYLQKQLDATTDE------KKETVTQLQNIIEANSQHYQK 232
E ++L L +L + +E +KE + ++Q ++ ++
Sbjct: 1552 QFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKE 1611
Query: 233 NINSL--------QEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQC 284
N + ++E LK E +E MC+IE ++ E + L ++ ++
Sbjct: 1612 NTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLT 1671
Query: 285 EASEKNIQKKYEC--ELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVK----HLE 338
+ +N+++ E ++LR + L+E + E++K HL+
Sbjct: 1672 QILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLK 1731
Query: 339 DTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEE-- 396
+ + ++ I+ ++ ++N++ LE +K + +E+L L +E
Sbjct: 1732 EHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETID 1791
Query: 397 --QGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEIS---ELNETFLSDSEKE 451
+G V EK +L+ + K + + ++Q LK + I+ ++NET SE E
Sbjct: 1792 KLRGIVSEKT-DKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEME 1850
Query: 452 KLTLMFEIQGL---KEQCENLQ---------QEKQEAILNYESLREIMEILQTELGESAG 499
+L + Q L K + ENL +E + + ++LR + E L+ E
Sbjct: 1851 QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER----- 1905
Query: 500 KISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGE-NEKLLSQQELVPELE 558
Q ES+++ +A D+ E+QQ+L+TA ETV++L+ + +EK + ++ +L+
Sbjct: 1906 --DQLKESLQETKARDL-EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLD 1962
Query: 559 NTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHE---------E 609
+ LQ+K + L +++ L ++ +N ++ +K + + +LK E
Sbjct: 1963 KSKDELQKK----IQELQKKELQLLRVKEDVN-MSHKKINEMEQLKKQFEAQNLSMQSVR 2017
Query: 610 MDNFH--KKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQ-KL 666
MDNF KK I + K+ ++ + L+ + ++ L E + QN Q K
Sbjct: 2018 MDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKP 2077
Query: 667 EKLMVQ--MKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHI 724
EK ++ + L+E + +K L + +++ + L+R + L ++++
Sbjct: 2078 EKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNR---LSLDLEKEI------ 2128
Query: 725 TQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGF--------LKEMGSEVSEDSEE 776
+ +K+L + V+ +L L+ + ++KLF Q LK + S V++ EE
Sbjct: 2129 -EFQKELSMRVKANLSL-PYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEE 2186
Query: 777 K---------DVVNVLQAVGESLAKIN--EEKCNLAFQRDEKVLELEKEIKCLQEESVVQ 825
+ D ++ ++ E L KI ++ C++ R+ + L+L + + EE +
Sbjct: 2187 QHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVP-SRELRDLKLNQNMDLHIEEILKD 2245
Query: 826 CEELKSLLRDYEQEKVLL-RKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEE 884
E + E ++VL RKE+ + E + D+ ++KN +K EN + QV
Sbjct: 2246 FSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQK---ENDRIC-QVNN 2301
Query: 885 -----VSQTCSKSEIHNEKEKCFIKEHE-NLKPLLEQKELRDRRAELILLKDSLAKSPSV 938
+ ++S E+ KE E +LK L E+ E + + LK SLA V
Sbjct: 2302 FFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQT--LKTSLASGAQV 2359
Query: 939 -------KNDPLSS--VKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSR---- 985
KN ++S + EKI LE E +E + +K +KEL+ +
Sbjct: 2360 NPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIA 2419
Query: 986 KETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEK-ERANNFE 1044
K V E + L K+ + + GA+ YK + + + + ++D+EK + A FE
Sbjct: 2420 KLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFE 2479
Query: 1045 HRI----------EDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLL--------- 1085
I +++ R LR + + + D + + SN L
Sbjct: 2480 KEISATKATVEYQKEVIRLLRENLRRSQQA-QDTSVISEHTDPQPSNKPLTCGGGSGIVQ 2538
Query: 1086 EVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQEL 1145
+ L ++ ++KE+ K Q EQ IK+ NEL L E KT +E
Sbjct: 2539 NTKALILKSEHIRLEKEISKLKQQNEQLIKQK----NELLSNNQHLSNE----VKTWKER 2590
Query: 1146 ELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEIT 1205
L ++ +Q T N + +++T K +L+ + + K
Sbjct: 2591 TLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSRSK 2650
Query: 1206 SLQS 1209
SL S
Sbjct: 2651 SLPS 2654
Score = 145 bits (366), Expect = 3e-34
Identities = 213/1063 (20%), Positives = 442/1063 (41%), Gaps = 155/1063 (14%)
Query: 645 VNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQL 704
VNE++ E LK + L+K + ++ + + + + ++ L EE + L + +
Sbjct: 335 VNEVSTD-EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEK 393
Query: 705 SRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLK 764
+L L + L++ + K+ +NK+ + + + T +
Sbjct: 394 IENLTRMLVTSSSLTLQQELKAKRKRRVTWC--LGKINKMKNSNYADQFNIPTNI----- 446
Query: 765 EMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVV 824
K +N+L+ + ES+ ++ N E +E K L +E++
Sbjct: 447 -------TTKTHKLSINLLREIDESVCSESDVFSNTLDTLSE--IEWNPATKLLNQENIE 497
Query: 825 QCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEE 884
EL SL DY+ L + E++++EKE ++ L E + +E LE +
Sbjct: 498 S--ELNSLRADYDN----LVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKT------- 544
Query: 885 VSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLS 944
++E I E NLK L++ E+ ++ L++ L+ + +
Sbjct: 545 ----------KKDQEMQLIHEISNLKNLVKHAEVYNQD-----LENELSSKVELLREKED 589
Query: 945 SVKELEE-----KIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLR 999
+K+L+E K+EN++ + E I K + K+ L + K E LR
Sbjct: 590 QIKKLQEYIDSQKLENIKMDLSYSLESIEDPK----QMKQTLFDAETVALDAKRESAFLR 645
Query: 1000 SEKDQLSASMRDLIQGAESYKNLLLEYEKQSE-----QLDVEKERANNF----------- 1043
SE +L M++L + +N + Y+ Q E Q+D+EKE + F
Sbjct: 646 SENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLID 705
Query: 1044 -------------EHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQIL 1090
E +I DL ++L + E + + LL+ +++L S + L +I
Sbjct: 706 GKVPKDLLCNLELEGKITDLQKELNKEVEENEALREE-VILLSELKSLPSEVERLRKEIQ 764
Query: 1091 EVQRAKAMVDKE---LEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELEL 1147
+ ++ E L +E + KE +++ + + ++ Q K + Q +
Sbjct: 765 DKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT 824
Query: 1148 VKKDAQQ--------TTLMNMEIAD-------YERLMKELNQKLTNKNNKIEDLEQEIKI 1192
+ D +Q MN EI + ++ + L +L+ K ++++ +E++
Sbjct: 825 LHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQE 884
Query: 1193 QKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGE 1252
+ + E L+E++ + S++Q E + T I + L +T +E+ Q + D LQ SL +
Sbjct: 885 RLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESL--Q 942
Query: 1253 LEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAE 1312
+E Q + +++ I +++ + S +QHQ T++ + +++ +E R E
Sbjct: 943 IERDQLKSDIHDTVNMNIDTQEQL--RNALESLKQHQETINTLKSKIS--EEVSRNLHME 998
Query: 1313 QATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKI-KLQDSQNN 1371
+ T ++ E + V KQ +Q T K E++ Q KI L +N
Sbjct: 999 ENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDN----EIIEQQRKIFSLIQEKNE 1054
Query: 1372 LQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQ 1431
LQ L+++ +E + L + ++ T+ + ELR ++ + ++ E + +
Sbjct: 1055 LQ---QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKK 1111
Query: 1432 LTSQNEVLRNSFR-DQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQS 1490
+ E+ R R +V +E + ++ QQQL ++ ++ +++ + ++ ++
Sbjct: 1112 ---EGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKK------INEIEN 1162
Query: 1491 LKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPP 1550
LKN E +N +L L M T E + + + E V S + + L++L S ET+
Sbjct: 1163 LKN--ELKNKELTLEHMETERLELAQKLNE-NYEEVKSITKERKVLKELQKSFETE---- 1215
Query: 1551 LWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQERE 1610
DHL G +RE EAT E++K+ ++ + +
Sbjct: 1216 ---------------------RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDEL 1254
Query: 1611 KSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEK 1653
+ + + E ++ K ++ + +PV++ +L P K
Sbjct: 1255 RRSVS-EKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVK 1296
Score = 52.0 bits (123), Expect = 5e-06
Identities = 121/621 (19%), Positives = 253/621 (40%), Gaps = 80/621 (12%)
Query: 1100 DKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN 1159
D+ L A + K ++ VNE+ + L++ +K++ ++LE V + + +
Sbjct: 314 DETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEK 373
Query: 1160 MEIA----DYERLMKELNQKLTNKNNKIE-----DLEQEIKIQKQKQET-LQEEITSLQS 1209
++A + + L K N+K+ N + L+QE+K +++++ T +I +++
Sbjct: 374 DQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKN 433
Query: 1210 S--VQQYE---EKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELE-------ASQ 1257
S Q+ TK +L + +E+ +S +E+D E+E +Q
Sbjct: 434 SNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQ 493
Query: 1258 QQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVT 1317
+ +E L +E L+T E+ + L E + K ++ +
Sbjct: 494 ENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLI 553
Query: 1318 SEFESYKVRV-HNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINV 1376
E + K V H + Q ++ ++ E +++ + ++ L + + DSQ I +
Sbjct: 554 HEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYI-----DSQKLENIKM 608
Query: 1377 SELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQN 1436
+L+S D + ETV+ +A + + ++SEN+ +K + + +L +
Sbjct: 609 DLSYSLESIEDPKQMKQTLFDAETVALDA--KRESAFLRSENLELK----EKMKELATTY 662
Query: 1437 EVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRE 1496
+ + N Q+ Q E +K ++ +E +L NE T + + + K+L
Sbjct: 663 KQMENDI--QLYQSQLEAKKKMQV------DLEKELQSAFNEITKLTSLIDGKVPKDLLC 714
Query: 1497 RRNTDLPLLDMHTVTREEGEGMETTDTESV--SSASTYTQSLEQL-------------LN 1541
+ + D+ +E E E E + S + +E+L +
Sbjct: 715 NLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIIT 774
Query: 1542 SPETKLEPPLWHAEFTKEELVQKLSSTT----------KSAD----HLNGLLRETEATNA 1587
S + KL + H E + L++++ T KS D + L + E
Sbjct: 775 SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYK 834
Query: 1588 ILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVL---LQFIFLKPGSERERLLPVINT 1644
+++E+ + + EI L ++E +K ++L LK L Q + K +ERL N
Sbjct: 835 MVLEENERMNQEIVNL--SKEAQKFDSSLGALKTELSYKTQELQEKTREVQERL----NE 888
Query: 1645 MLQLSPEEKGKLAAVAQGEEE 1665
M QL + + + + + E E
Sbjct: 889 MEQLKEQLENRDSTLQTVERE 909
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 228 bits (580), Expect = 5e-59
Identities = 379/1782 (21%), Positives = 745/1782 (41%), Gaps = 276/1782 (15%)
Query: 31 IKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQ 90
IK K+Q+ L+ +A+ E +E E+ S + + E A + K E +
Sbjct: 928 IKTLKEQLNLLSRAEEAKKEQVEEDNEVSS--------GLKQNYDEMSPAGQISKEELQH 979
Query: 91 QCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELM-------AVRS 143
+ LKKEN + K++++ ++ KEL Q +E+ NLK+E R
Sbjct: 980 EFDLLKKENEQRKRKLQAALIN----RKELLQRVSRLEEELANLKDESKKEIPLSETERG 1035
Query: 144 KYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVK--KLQEEIEKIRPGFEEQILYL 201
+ EDK N ++ E+ + ++ + E Q SE V+ +++++E+ + EEQ L
Sbjct: 1036 EVEEDKEN-KEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEE-KLAAEEQFQAL 1093
Query: 202 QKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEA 261
KQ++ T +K + LQ I N QK I S + +E +
Sbjct: 1094 VKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTG 1153
Query: 262 SAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQ 321
S++ + E+ E + E ++ +QKK + L + RKA Q
Sbjct: 1154 SSEHWKPEL-------EEKILALEKEKEQLQKKLQEALTS-RKAILKKAQ---------- 1195
Query: 322 ENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHERE 381
EK +HL + LK+ + ++ L+++ + + E ++ RE
Sbjct: 1196 ----------EKERHLREELKQQKDDYNRLQEQFDEQSK---ENENIGDQLRQLQIQVRE 1242
Query: 382 DLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELN 441
++ K+ +++ C S GL + EQH H + + E N
Sbjct: 1243 SIDGKLPS---TDQQESC------SSTPGLEEPLFKATEQH----------HTQPVLESN 1283
Query: 442 ETFLSDSEKEKLTLM---FEIQGLKEQCENLQQEKQEAILNYESL-----REIMEILQTE 493
S E + + + +K Q + ++ EK E L S ++ E+ Q
Sbjct: 1284 LCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQ-- 1341
Query: 494 LGESAGKISQEFESMKQ-QQASDVH--ELQQKLRTAFTEKDALLETVNRLQ---GENEKL 547
L E K E ES+K ++VH LQQKL ++ + A LE + LQ E +KL
Sbjct: 1342 LQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQI-AGLEHLRELQPKLDELQKL 1400
Query: 548 LSQQELVPELENTIKNLQEKNGVYL---LSLSQRDTMLKELEGKINSLTEEKDDFINKLK 604
+S++E ++ L EK + +++ ++K L ++ +E D+ I +L+
Sbjct: 1401 ISKKE--EDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQ 1458
Query: 605 NSHEEMDNFHKKCEREERLILELGKKVE-------QTIQYNSELEQKVNELTGGLEETLK 657
EM ++ E R ++ +K++ + ++ N L+++++ G +E K
Sbjct: 1459 VELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTK 1518
Query: 658 -----EKDQNDQKLEK--LMVQMKVLSEDKEVLSAEVKSLYEENNKLSS----------- 699
E + Q EK ++ ++ +L E+++ L E+ EN LSS
Sbjct: 1519 SLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEG 1578
Query: 700 ---EKKQLSRDLEVFLSQK--EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLF 754
+K++L +++E S K E +E +L+K+ +++++ +N++ E E++Q +
Sbjct: 1579 LTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSN--EAERIQHVV 1636
Query: 755 V-----KTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVL 809
K +LYG L+ S ++ +K+ LQ + + ++ E+ A + +K+L
Sbjct: 1637 EAVRQEKQELYGKLR------STEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKIL 1690
Query: 810 ELEKEIKCLQEE------SVVQCEE--------LKSLLRDYEQEKVLLRKELEEIQSEKE 855
ELE+E L+ E + +C E +K L + E L K+ + + SEK+
Sbjct: 1691 ELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKD 1750
Query: 856 ALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENL----KP 911
+L ++ ++K+ E + NL + +QT + +E + +E ++L +P
Sbjct: 1751 SLSEEVQDLKHQIEGNVSKQANLEATEKHDNQT-NVTEEGTQSIPGETEEQDSLSMSTRP 1809
Query: 912 LLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIK 971
+ + A + KD S N+ L + +L+E+I LE+E K+K ++ ++
Sbjct: 1810 TCSESVPSAKSANPAVSKD--FSSHDEINNYLQQIDQLKERIAGLEEE-KQKNKEFSQ-- 1864
Query: 972 LVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSE 1031
+ E ++ + T EL+ L+ E +++ + + E + E E
Sbjct: 1865 ----TLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQI---QEELSRVTKLKETAEE 1917
Query: 1032 QLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILE 1091
+ D +ER N ++ +L + N NE L + ++ L+ LE + +
Sbjct: 1918 EKDDLEERLMN---QLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQ 1974
Query: 1092 VQRAKAMVDKELE---AEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELV 1148
+ + K V+ E+ EK+Q QK + + EL+EL + Q+E KQLQK +
Sbjct: 1975 LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQ-- 2032
Query: 1149 KKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQ 1208
+I+ ER +K L T +E ++ + + ++ Q E+ S +
Sbjct: 2033 -----------EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFK 2081
Query: 1209 SSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQ-ASLKGELEASQQQVEVYKIQL 1267
+ + + ++ +K KKEL +K++ + + L+ LE ++++ K +
Sbjct: 2082 VLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNM 2141
Query: 1268 AEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRV 1327
E + HL+ + + Q TL+ + V LQE + + A T S +
Sbjct: 2142 QEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDR 2201
Query: 1328 HNVLKQQKN-----KSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTL 1382
V+ + K Q++ E + + ++ +L DQL+ ++ L+IN+S L+
Sbjct: 2202 DRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLR-QMSIHMEELKINISRLE-- 2258
Query: 1383 QSEHDTLLERHNKMLQETVSK-EAELREKLC-SIQSENMMMKSEHTQTVSQL-TSQNEVL 1439
H+K + E+ ++ E +L++K+C ++Q EN + S+ +T +SQNE+
Sbjct: 2259 ----------HDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELA 2308
Query: 1440 R-----NSFRDQVRHLQEEHRKTVE-------TLQQQLSKMEAQLFQLKNEPT----TRS 1483
+ S +DQ+ L K E ++QQ + ++ F + T +R
Sbjct: 2309 KLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRE 2368
Query: 1484 PVSSQQSLKNLRE---------------------RRNTDLPLLDMHTVTREEGEGMETTD 1522
S N++E R+ D + ++ + +E E +
Sbjct: 2369 LTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLE 2428
Query: 1523 TESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNG----- 1577
E+ + Q +E L + ++ + + V+ +SS D + G
Sbjct: 2429 EENKKAVDKTNQLMETLKTIKKENIQ-----QKAQLDSFVKSMSSLQNDRDRIVGDYQQL 2483
Query: 1578 -------------LLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLL 1624
L++E A N L E+I+ L+S + L N E K A L + L
Sbjct: 2484 EERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDL--NSENAKLDAELIQYREDLN 2541
Query: 1625 QFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEEN 1666
Q I +K +++ ++ LQ + E + K A + + +E+
Sbjct: 2542 QVITIKDSQQKQ----LLEVQLQQNKELENKYAKLEEKLKES 2579
Score = 217 bits (552), Expect = 9e-56
Identities = 374/1751 (21%), Positives = 737/1751 (42%), Gaps = 254/1751 (14%)
Query: 23 ETLPKEDLIKFAKKQM-MLIQKAKSRCTELEKEIEELRS---KPVTEGT----GDIIKAL 74
E L E+ + KQM +Q ++ L+ EI E ++ K +T T GD + +
Sbjct: 1082 EKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALV 1141
Query: 75 TERL-------DALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINY 127
E + + K E E++ L+L+KE ++++++++++T K+ ++ +
Sbjct: 1142 KETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHL 1201
Query: 128 VKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEI 187
+E++ K++ ++ ++ E + ++ Q+++ E + + S D Q+E
Sbjct: 1202 REELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTD-----QQES 1256
Query: 188 EKIRPGFEEQILYLQKQL-------------------DATTDEKKETVTQLQ---NIIEA 225
PG EE + +Q DA+ + +V Q++ IEA
Sbjct: 1257 CSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEA 1316
Query: 226 NSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKE--------HEAEINKLNELK 277
+ ++S EL + EEV +L QI E HEAE++
Sbjct: 1317 EKVELELKVSSTTSELTK----KSEEVFQLQEQINKQGLEIESLKTVSHEAEVHA----- 1367
Query: 278 ENLVKQCEASEKNIQ-----KKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNE 332
E+L ++ E+S+ I ++ + +L+ L+K S +D S L E +
Sbjct: 1368 ESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQT 1427
Query: 333 KVKHLEDTLKELESQHSILKDEVTYMNNLK-LKLEMDAQHIKDEFFHE----REDLEFKI 387
++ ED +K L +Q + E + +K L++E+ K E E ++ ++ K+
Sbjct: 1428 EIIEQEDLIKALHTQLEMQAKE--HDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL 1485
Query: 388 NELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSD 447
L++++E + L+ EL+ T+E+ + + ++ Q +S
Sbjct: 1486 QAALISRKEALKENKSLQEELSLARG----TIERLTKSLADVESQ------------VSA 1529
Query: 448 SEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELG---ESAGKISQE 504
KEK T++ + L+E+ + L E ++L +SL E L+ L E K+ +E
Sbjct: 1530 QNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKE 1589
Query: 505 FESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNL 564
ES+K + ++ E Q+K + E + LL++ + E E++ E V
Sbjct: 1590 IESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVR--------- 1640
Query: 565 QEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLI 624
QEK +EL GK+ S K + +L+ + +EM+ +K +
Sbjct: 1641 QEK---------------QELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRK----- 1680
Query: 625 LELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLS 684
K +Q I ELE++ + L E D + +E L+ + E+ E +
Sbjct: 1681 --FAKSKQQKIL---ELEEENDRLRA---EVHPAGDTAKECMETLLSSNASMKEELERVK 1732
Query: 685 AEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKL--QLMVEEQDNLN 742
E ++L ++ L SEK LS +++ Q E + K+ + +K Q V E+ +
Sbjct: 1733 MEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQS 1792
Query: 743 KLLENEQVQKLFVKT-----QLYGFLKEMGSEVSED-SEEKDVVNVLQAVG---ESLAKI 793
E E+ L + T + K VS+D S ++ N LQ + E +A +
Sbjct: 1793 IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGL 1852
Query: 794 NEEKCNLAFQRDEKVLE-LEKEIKCLQEESVVQCEELKSLLRDYEQEKVL---LRKELEE 849
EEK Q++++ + LE E L + + ELK L + + +L +++EL
Sbjct: 1853 EEEK-----QKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSR 1907
Query: 850 IQSEKEALQS--DLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEK----EKCFI 903
+ KE + D LE + N+ L N ++ ++V+ K+E+ + +KC
Sbjct: 1908 VTKLKETAEEEKDDLEERLMNQLAEL-NGSIGNYCQDVTDAQIKNELLESEMKNLKKCVS 1966
Query: 904 KEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDP--LSSVKELEE-------KIE 954
+ E + L+++K + E + K+ L K + +P S KEL+E +++
Sbjct: 1967 ELEEEKQQLVKEKT----KVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVK 2022
Query: 955 NLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESL---RSEKDQLSASMRD 1011
L+K+C +EKI+ ++ + S+K+ + KE L R + AS +
Sbjct: 2023 QLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKV 2082
Query: 1012 LIQGAESYK------NLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETIN 1065
L+ +S NL L+ E QS + V+ + + + EDL R+L + E
Sbjct: 2083 LLDDTQSEAARVLADNLKLKKELQSNKESVKSQ----MKQKDEDLERRLEQAE---EKHL 2135
Query: 1066 SDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELE 1125
+ +++ +++ L+ LE I E+Q DKE++ + + + + A +
Sbjct: 2136 KEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMS 2195
Query: 1126 ELQVQLQK--------EKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLT 1177
LQ + E+K + E ++ +++ ++ M+EL ++
Sbjct: 2196 SLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINIS 2255
Query: 1178 NKNNKIEDLEQ----EIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELA 1233
+ + E E+++Q++ +TLQ E L S +++ + L K + EL
Sbjct: 2256 RLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELK 2315
Query: 1234 DSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLS 1293
K TD L LE ++Q K L I ++ ++ K S EQ + L
Sbjct: 2316 SLKDQLTD-------LSNSLEKCKEQ----KGNLEGIIRQQEADIQNSKFSYEQLETDLQ 2364
Query: 1294 AYQQRVTALQEECRAAKAEQATVTS-EFESYKVRVHNVLKQQKNKSMSQAETEGAKQERE 1352
A ++ + L EE + + ++ S + E+ +V + L+QQ +K + + E +++E E
Sbjct: 2365 ASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAE-LRQQHDKEIKELENLLSQEEEE 2423
Query: 1353 HLEM-------------LIDQLK-IKLQDSQNNLQIN----------------VSELQTL 1382
++ + L++ LK IK ++ Q Q++ V + Q L
Sbjct: 2424 NIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQL 2483
Query: 1383 QSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRN- 1441
+ H +++ ++++QE ++ +L+E++ ++S + SE+ + ++L E L
Sbjct: 2484 EERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQV 2543
Query: 1442 -SFRD-QVRHLQEEHRKTVETLQQQLSKMEAQLFQLK--NEPTTRS----PVSSQQSLKN 1493
+ +D Q + L E + + L+ + +K+E +L + + NE RS Q K
Sbjct: 2544 ITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKE 2603
Query: 1494 LRERRNTDLPLLDMHTVTREEG-----EGMETTDTESVSSASTYTQSLEQLLNSPETKLE 1548
+ + + L T +EEG E V S S ++ + E +L
Sbjct: 2604 IESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELV 2663
Query: 1549 PPLWHAEFTKEELVQKLSSTTKSADHLNGLLR-ETEATNAILMEQIK-LLKSEIRRLERN 1606
A E+ KL K H G++R ETE + E + L++ E + L
Sbjct: 2664 CVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVT 2723
Query: 1607 QEREKSAANLE 1617
+E + A ++
Sbjct: 2724 KENKGLTAQIQ 2734
Score = 215 bits (547), Expect = 3e-55
Identities = 369/1816 (20%), Positives = 754/1816 (41%), Gaps = 281/1816 (15%)
Query: 19 KSKLETLPKEDLIKFAKKQM-MLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTER 77
K + E + +EDLIK Q+ M ++ R +L+ E+ E++ KP G K +R
Sbjct: 1424 KIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQR 1483
Query: 78 -LDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKE----------------- 119
L A L+ + E ++ SL++E + +E + D +
Sbjct: 1484 KLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLAL 1543
Query: 120 LEQSHINYVKEIENLKNELMAVRSK----------YSEDKANLQKQLEEAMNTQL----- 164
L++ + E++ E ++ S +EDK L K++E ++++
Sbjct: 1544 LQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTE 1603
Query: 165 ------ELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQ 218
EL ++ + S +NV E I+ + ++ L +L +T KKET Q
Sbjct: 1604 WQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQ 1663
Query: 219 LQNI---IEANSQHYQKNINSLQEELLQLK----------------------------AI 247
LQ +E + +K S Q+++L+L+ A
Sbjct: 1664 LQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNAS 1723
Query: 248 HQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECEL----ENLR 303
+EE++ + + E +K+ ++ +++ + L E + E N+ K+ E +N
Sbjct: 1724 MKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQT 1783
Query: 304 KATSNANQ------DNQICSILLQENTFVEQVVNEKVKH--------LEDTLKELESQHS 349
T Q + Q + T E V + K + D + Q
Sbjct: 1784 NVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQID 1843
Query: 350 ILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEE---QGCVIEKLKS 406
LK+ + + K K + +Q +++E + K EL + +EE + ++++
Sbjct: 1844 QLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQE 1903
Query: 407 ELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETF------LSDSEKEKLTLMFEIQ 460
EL+ + K E E L+E+ +++ELN + ++D++ + L E++
Sbjct: 1904 ELSRVTK----LKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMK 1959
Query: 461 GLKEQCENLQQEKQEAI-----LNYESLREIMEILQTELGESAGKI-SQEFESMKQQQAS 514
LK+ L++EKQ+ + + E +E +E +Q E K ++E + + +++
Sbjct: 1960 NLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ 2019
Query: 515 DVHELQQKLRTAFTEKDALLETVNRL---QGENEKLL--SQQELVPELENTIKNLQEKNG 569
+V +LQ+ + AL TV L Q E++K L +++ L +E+ K E
Sbjct: 2020 EVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELAS 2079
Query: 570 VYLLSLSQRDTMLKELEGKIN---SLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILE 626
+L + + L + L K+ +++K E+++ ++ E+ E L+
Sbjct: 2080 FKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLE---RRLEQAEEKHLK 2136
Query: 627 LGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAE 686
K +++ + + + E G ++ TL +KD+ Q+L++ + +
Sbjct: 2137 EKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQE---NLDSTVTQLAAFTKS 2193
Query: 687 VKSLYEENNKLSSEKKQLSRDL-EVFLSQKEDVILKEHITQLEK----KLQLMVEE-QDN 740
+ SL ++ +++ E K+ R + S++E++ LKE + K ++ + +EE + N
Sbjct: 2194 MSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKIN 2253
Query: 741 LNKLLENEQVQKLFVKTQ----------LYGFLKEMGSEVSE---------------DSE 775
+++L ++Q+ + +T+ L G KE+ S++ E +SE
Sbjct: 2254 ISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESE 2313
Query: 776 EKDVVNVLQAVGESLAKINEEKCNLA--FQRDEKVLELEKEIKCLQEESVVQCEELKSLL 833
K + + L + SL K E+K NL ++ E ++ K E + EL S L
Sbjct: 2314 LKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRL 2373
Query: 834 RDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSE 893
+E+ + +K + + ++EA+Q + E++ ++K E +NLL Q EE +
Sbjct: 2374 --HEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV----- 2426
Query: 894 IHNEKEKCFIKEHENLKPLLE-QKELRDRRAELILLKDSLAKS-PSVKNDPLSSVKELEE 951
+ E +K K ++ ++ L +KE ++A+L DS KS S++ND V + ++
Sbjct: 2427 LEEENKKAVDKTNQLMETLKTIKKENIQQKAQL----DSFVKSMSSLQNDRDRIVGDYQQ 2482
Query: 952 KIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRD 1011
E EK++ I + A E + ++E + ++ ++ L SE +L A +
Sbjct: 2483 LEERHLSIILEKDQLIQE-------AAAENNKLKEEIRGLRSHMDDLNSENAKLDA---E 2532
Query: 1012 LIQGAESYKNLLLEYEKQSEQL-DVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNED 1070
LIQ E ++ + Q +QL +V+ ++ E++ L +L+ S E +
Sbjct: 2533 LIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNA 2592
Query: 1071 LLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEH---------ATTV 1121
L + L + L+V I ++ R + +E + K+KE +++
Sbjct: 2593 LQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQ 2652
Query: 1122 NELEELQVQLQKEKKQLQKTMQELE-LVKKDAQQ----TTLMNMEIADYERLMKELNQKL 1176
+ EL+ +L +K+ K + E+E +KK+ + +M E E + EL + L
Sbjct: 2653 KRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDL 2712
Query: 1177 TNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSK 1236
K+ + +E K + ++ ++SLQ+S E+ ++K+ + KELA K
Sbjct: 2713 VEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLK 2772
Query: 1237 QA-----ETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRT 1291
+ E D L+ + + + K+ ++ ++ +H L + E
Sbjct: 2773 EQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLH--LSSQLEDSYNQ 2830
Query: 1292 LSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQER 1351
+ ++ + + +LQ E + + +E E ++ + S S AE + K+
Sbjct: 2831 VQSFSKAMASLQNE-------RDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAM 2883
Query: 1352 EHLEMLIDQLKIKLQDSQNN-LQIN--VSELQTLQSEHDTLLER-------HNKMLQETV 1401
L+ D+L +L++ Q LQIN ++EL L+++ ++ ++ QE +
Sbjct: 2884 SSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENL 2943
Query: 1402 SKEAELRE--------------------------------------KLCSIQSENMMMKS 1423
S + EL + +L S S+ +K
Sbjct: 2944 SWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKV 3003
Query: 1424 EHTQTVSQLTS-----------QNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQL 1472
++ + S TS + E+LR D L+E H+K + QQL+ +QL
Sbjct: 3004 QYQRQASPETSASPDGSQNLVYETELLRTQLNDS---LKEIHQKELRI--QQLNSNFSQL 3058
Query: 1473 FQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTE-SVSSAST 1531
+ KN + + +SQ +LRE + LL+ V ++ + ++ V+ +
Sbjct: 3059 LEEKNTLSIQLCDTSQ----SLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAP 3114
Query: 1532 YTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILME 1591
++ + PE EP + + E Q+L +T + + L LL E
Sbjct: 3115 QEKNGVHRKSDPEELREP-----QQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAEN 3169
Query: 1592 QIKLLKSEIRRLERNQ 1607
+ + + +IRRLE ++
Sbjct: 3170 ALSVAEEQIRRLEHSE 3185
Score = 199 bits (506), Expect = 2e-50
Identities = 313/1536 (20%), Positives = 652/1536 (42%), Gaps = 247/1536 (16%)
Query: 1 MEDLVQDGVASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRS 60
ME L+ + K + ETL K+ ++K L ++ + ++E + + +
Sbjct: 1714 METLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDS-LSEEVQDLKHQIEGNVSKQAN 1772
Query: 61 KPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLK---KENIKMKQEVEDSVTKMGDAH 117
TE + E ++ E E + +S + E++ + +V+K +H
Sbjct: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH 1832
Query: 118 KELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLE-----------L 166
E+ NY+++I+ LK + + + ++K + LE NT L L
Sbjct: 1833 DEIN----NYLQQIDQLKERIAGLEEEKQKNK-EFSQTLENEKNTLLSQISTKDGELKML 1887
Query: 167 SEQLKFQN-------NSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQL 219
E++ N V KL+E E+ + EE+++ +L+ + + VT
Sbjct: 1888 QEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDA 1947
Query: 220 Q---NIIEANSQHYQKNINSLQEELLQL----KAIHQEEVKELMCQIEASAKE-----HE 267
Q ++E+ ++ +K ++ L+EE QL + E KE + +I+ + KE H
Sbjct: 1948 QIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHA 2007
Query: 268 AEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVE 327
E+ +L + K+ VKQ + Q+K LE KA ++Q + +EN
Sbjct: 2008 KELQELLKEKQQEVKQLQKDCIRYQEKISA-LERTVKALEFVQTESQKDLEITKEN---- 2062
Query: 328 QVVNEKVKHLEDTLKELESQHSILKDEVT-----YMNNLKLKLEMDA--QHIKDEFFHER 380
+ + V+H + EL S +L D + +NLKLK E+ + + +K + +
Sbjct: 2063 --LAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKD 2120
Query: 381 EDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISEL 440
EDLE ++ + A+E+ + ++ +L L ++ + +E+ E+Q + KE+ +L
Sbjct: 2121 EDLERRLEQ---AEEKHLKEKKNMQEKLDALRREKVH-LEETIGEIQVTLNKKDKEVQQL 2176
Query: 441 NE------TFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTEL 494
E T L+ K +L + + ++ + +++ +AI + E + E + L
Sbjct: 2177 QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVL 2236
Query: 495 GESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQ---- 550
+ ++S E +K + H+ Q A TE + + LQGEN++LLSQ
Sbjct: 2237 KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEET 2296
Query: 551 -------QELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKL 603
Q + +LE+ +K+L+++ L LS KE +G + + +++ I
Sbjct: 2297 RHLYHSSQNELAKLESELKSLKDQ----LTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS 2352
Query: 604 KNSHEEMDN-----------FHKKCEREERLILELGKKVEQTIQY--------------- 637
K S+E+++ H++ +E+ I+ L E+ IQ
Sbjct: 2353 KFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKE 2412
Query: 638 ------------------NSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSED 679
N + K N+L L+ KE Q +L+ + M L D
Sbjct: 2413 LENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQND 2472
Query: 680 KEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVI--LKEHITQLEK---KLQL- 733
++ + + + L E + + EK QL ++ ++ ++ I L+ H+ L KL
Sbjct: 2473 RDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAE 2532
Query: 734 MVEEQDNLNKLL---ENEQVQKLFVKTQL-------YGFLKEM---GSEVSED------- 773
+++ +++LN+++ +++Q Q L V+ Q Y L+E E +ED
Sbjct: 2533 LIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNA 2592
Query: 774 --SEEKDVVNVLQAVGESLA----------------------KINEEKCN----LAFQRD 805
E++D+ ++++ S++ K+ EE+ + L
Sbjct: 2593 LQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQ 2652
Query: 806 EKVLELEKEIKCLQEESVVQCEE----LKSLLRDYEQEKVLLRKELEEIQSEKEALQSDL 861
+++ ELE+E+ C+Q+E+ + E LK L+ + ++R E E + L DL
Sbjct: 2653 KRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDL 2712
Query: 862 LEMKNANEKTRLENQNLLIQVEEVSQTC-----SKSEIHNEKEKCFIKEHENLKPLLEQK 916
+EM+ EN+ L Q++ ++ S+ + E ++ K +LK L + K
Sbjct: 2713 VEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLK 2772
Query: 917 E--LRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVA 974
E L +R + +L + + + + + +N S+ LE+ L ++ K+E++
Sbjct: 2773 EQGLLNRERDALLSETAFSMNSTEEN----SLSHLEK----LNQQLLSKDEQL------- 2817
Query: 975 VKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLD 1034
+ +L+ S + Q+ + + SL++E+D L + + E + + ++
Sbjct: 2818 LHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQ 2877
Query: 1035 VEKERANNFEHRIEDLTRQLRNSTLQCETINSDNED---LLARIETLQSNAKLLEVQILE 1091
K+ ++ ++ + L ++L+N Q IN + + L A+++ Q K ++ E
Sbjct: 2878 SLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEE 2937
Query: 1092 VQRAKAMVDKELEAEKLQK------EQKIKE-HATTVNELEELQVQLQKEKKQLQKTMQE 1144
+++ EL +++K E+++KE + +++ ++ LQ ++L+ + +
Sbjct: 2938 LRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQ 2997
Query: 1145 LELVKKDAQQTTLMNMEIA--DYERLMKELNQKLTNKNNKIEDLEQ-EIKIQKQKQETLQ 1201
+ +K Q+ + + L+ E T N+ ++++ Q E++IQ+
Sbjct: 2998 TQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQ------- 3050
Query: 1202 EEITSLQSSVQQ-YEEKNTKIKQLLVKTKKELADSKQAETD---HLILQASLKGELEASQ 1257
L S+ Q EEKNT Q L T + L +++Q D H + EL+A
Sbjct: 3051 -----LNSNFSQLLEEKNTLSIQ-LCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGP 3104
Query: 1258 QQVEVYKIQLAEITSEKHKIHEHLKTSAE---QHQRTLSAYQQRVTALQEECRAAKAEQA 1314
++V EK+ +H K+ E + Q++ S QQ++ ++E E
Sbjct: 3105 LNIDV----APGAPQEKNGVHR--KSDPEELREPQQSFSEAQQQLCNTRQEVN----ELR 3154
Query: 1315 TVTSEFESYKVRVHNVLK--QQKNKSMSQAETEGAK 1348
+ E +V N L +++ + + +E + ++
Sbjct: 3155 KLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSR 3190
Score = 199 bits (505), Expect = 2e-50
Identities = 377/1782 (21%), Positives = 754/1782 (42%), Gaps = 285/1782 (15%)
Query: 42 QKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIK 101
++A ELE L K E ++ T + +L E + C +LK +N K
Sbjct: 350 EQAGQAQAELESRYSALEQKHKAE-----MEEKTSHILSLQKTGQELQSACDALKDQNSK 404
Query: 102 MKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNEL------------------MAVRS 143
+ Q+ + + ++LE KEI N L ++
Sbjct: 405 LLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQA 464
Query: 144 KYSEDKANLQKQLEEAMN-------TQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEE 196
E+ A+LQK++ E N + +EL E+LK +N + L E + R G +
Sbjct: 465 VTEENIASLQKRVVELENEKGALLLSSIEL-EELKAENEKLSSQITLLE--AQNRTGEAD 521
Query: 197 QILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELM 256
+ + +D Q+++E K ++ L LL++K QEE+ L
Sbjct: 522 REVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVL---LLEMKEA-QEEIAFLK 577
Query: 257 CQIEAS-AKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENL--------RKATS 307
Q++ A+E + E+ L + +KQ E E K + LE+ + +S
Sbjct: 578 LQLQGKRAEEADHEV-----LDQKEMKQME-GEGIAPIKMKVFLEDTGQDFPLMPNEESS 631
Query: 308 NANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSIL-------KDEVTYMNN 360
+ + S Q T E +N+ L+ T ++ + S + +DE+ + +
Sbjct: 632 LPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKS 691
Query: 361 LKLKLEMDAQHIKDEFFHEREDL-EFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTV 419
L+LE++ FH+ +++ E ++E +IE+ K + F
Sbjct: 692 QILELELN--------FHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALS 743
Query: 420 EQHNREVQSLKE-----QHQKEISELNETFLSDSEKEKLTLMFEIQG-----LKEQCENL 469
E+ ++ + +KE + + ++ +L E L+++E+++ L +E Q L EQ +L
Sbjct: 744 EERDQLLSQVKELSMVTELRAQVKQL-EMNLAEAERQR-RLDYESQTAHDNLLTEQIHSL 801
Query: 470 QQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTE 529
E + + E L+ ++ +Q + E + I + +S Q + S+V E +++R ++
Sbjct: 802 SIEAKSKDVKIEVLQNELDDVQLQFSEQSTLI-RSLQSQLQNKESEVLEGAERVRHISSK 860
Query: 530 KDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELE--- 586
+ L + +++ + E K+ +L+ E + ++ LQ+ ++ ++D + E+
Sbjct: 861 VEELSQALSQKELEITKM---DQLLLEKKRDVETLQQ-------TIEEKDQQVTEISFSM 910
Query: 587 -GKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKV 645
K+ L EEK ++K E++ N + E ++ ++VE+ + +S L+Q
Sbjct: 911 TEKMVQLNEEKFSLGVEIKTLKEQL-NLLSRAEEAKK------EQVEEDNEVSSGLKQNY 963
Query: 646 NELTGG-----------LEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEEN 694
+E++ + KE +Q +KL+ ++ K L + L E+ +L +E+
Sbjct: 964 DEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDES 1023
Query: 695 NK-------------LSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNL 741
K E K+ S Q+ ++ LK+ I+ EK+++L +D
Sbjct: 1024 KKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTIS--EKEVELQHIRKDLE 1081
Query: 742 NKLLENEQVQKLFVKTQLYGFLKEMGSEV----SEDSEEKDVV------NVLQAVGESLA 791
KL EQ Q L Q+ L++ +++ +E SE + ++ N + G+S+A
Sbjct: 1082 EKLAAEEQFQALV--KQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVA 1139
Query: 792 KINE-----EKCNLAFQR-----DEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKV 841
+ E C + + +EK+L LEKE + LQ++ K++L+ ++++
Sbjct: 1140 LVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKER 1199
Query: 842 LLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKC 901
LR+EL++ + + LQ E NE + + L IQV E K +++E C
Sbjct: 1200 HLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRE--SIDGKLPSTDQQESC 1257
Query: 902 FIKEHENLKPLLEQ---KELRDRRAELILLKDSLAKSPSVKNDPL-----SSVKELEEKI 953
+ P LE+ K + +L + PS D +SV +++ ++
Sbjct: 1258 ------SSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQL 1311
Query: 954 ENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLI 1013
+ +E E E E K++ K +E+ +++ E+ESL++ + L
Sbjct: 1312 KEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQ 1371
Query: 1014 QGAESYKNLLLEYEKQSE---QLDVEKERANNFEHRIEDLTRQLRN-----STLQCETIN 1065
Q ES + + E E +LD ++ + E + L+ QL + +Q E I
Sbjct: 1372 QKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEII- 1430
Query: 1066 SDNEDLLARIET-LQSNA-------KLLEVQILEVQ----------RAKAMVDKELEAEK 1107
+ EDL+ + T L+ A K L+V++ E++ RAK + ++L+A
Sbjct: 1431 -EQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAAL 1489
Query: 1108 LQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYER 1167
+ +++ +KE+ + EL + +++ K L ++ K+ + T L + + ER
Sbjct: 1490 ISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKE-KDTVLGRLALLQEER 1548
Query: 1168 --LMKELNQKLTNK---NNKIEDLEQEIKIQKQKQETLQEEITSLQSS----VQQYEEKN 1218
L+ E+++ L ++ E L+ ++ + +E L +EI SL+SS +++EK+
Sbjct: 1549 DKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKH 1608
Query: 1219 TKIK---QLLVKTKKELADSKQAETDHLILQA------SLKGELEASQQQVEVYKIQLAE 1269
+++ ++L+++ + + S +AE +++A L G+L +++ + + QL E
Sbjct: 1609 KELQKEYEILLQSYENV--SNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQE 1666
Query: 1270 ITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHN 1329
E ++ E ++ A+ + QQ++ L+EE +AE V ++ K +
Sbjct: 1667 AEQEMEEMKEKMRKFAK-------SKQQKILELEEENDRLRAE---VHPAGDTAKECMET 1716
Query: 1330 VLKQQKNKSMSQAETEGAKQEREHLEMLI-------DQLKIKLQDSQNNLQINVSELQTL 1382
+L N SM + E E K E E L D L ++QD ++ ++ NVS+ L
Sbjct: 1717 LL--SSNASMKE-ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANL 1773
Query: 1383 QS--EHD---TLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNE 1437
++ +HD + E + + ++ L SE++ VS+ S ++
Sbjct: 1774 EATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHD 1833
Query: 1438 VLRN------SFRDQVRHLQEEHRKTVE----------TLQQQLSKMEAQLFQLKNEPTT 1481
+ N ++++ L+EE +K E TL Q+S + +L L+ E T
Sbjct: 1834 EINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTK 1893
Query: 1482 RSPVSSQ--------QSLKNLRERRNTDLPLLDMHTVTREEGE----GMETTDTE----- 1524
+ ++ Q LK E DL M+ + G + TD +
Sbjct: 1894 MNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNEL 1953
Query: 1525 ------SVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGL 1578
++ + + +Q L +TK+E + K + QK A L L
Sbjct: 1954 LESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQEL 2013
Query: 1579 LRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLK 1620
L+E + E +L K IR E+ E++ LE+++
Sbjct: 2014 LKEKQ------QEVKQLQKDCIRYQEKISALERTVKALEFVQ 2049
Score = 157 bits (397), Expect = 8e-38
Identities = 299/1502 (19%), Positives = 633/1502 (42%), Gaps = 213/1502 (14%)
Query: 231 QKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKN 290
Q+ + ++ +++LK I +++ +L + EA +E +A NK+ +LK + + + K
Sbjct: 51 QERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKY 110
Query: 291 IQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSI 350
I+ E + + + + Q+ +++ E++ EK+KH L+E E S
Sbjct: 111 IE---EMKAQGGTVLPTEPQSEEQLSK--HDKSSTEEEMEIEKIKH---KLQEKEELIST 162
Query: 351 LKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAG 410
L+ ++T + + E AQ E EF + + L ++E+ I L+++L+
Sbjct: 163 LQAQLT-----QAQAEQPAQ-------SSTEMEEFVMMKQQLQEKEE--FISTLQAQLS- 207
Query: 411 LNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQ-GLKEQCENL 469
Q E + + +K+ + L + E +L +++ ++++ L
Sbjct: 208 ----------QTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVL 257
Query: 470 QQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTE 529
Q++ +E + +++++LQ EL + +Q + + L Q+L+ E
Sbjct: 258 QRKLEEHEESLVGRAQVVDLLQQELTAA-------------EQRNQI--LSQQLQQMEAE 302
Query: 530 KDALLETVNRLQGENEKLLSQQEL-VPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGK 588
+ L TV + E++ LL + EL V E + + NLQE+ L Q ELE +
Sbjct: 303 HNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESR 362
Query: 589 INSL-------TEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSEL 641
++L EEK I L+ + +E+ + + + +L+ K EQ +Q +
Sbjct: 363 YSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQ--DKNEQAVQSAQTI 420
Query: 642 EQKVNELTGGLEETLKEKDQN-DQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSE 700
+Q LE+ L++K + Q L +L +Q + + +Y E + +E
Sbjct: 421 QQ--------LEDQLQQKSKEISQFLNRLPLQ-----QHETASQTSFPDVYNEGTQAVTE 467
Query: 701 KKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKL-LENEQVQKLFVKTQL 759
+ S L++ + +LE + ++ L +L ENE++ +
Sbjct: 468 ENIAS--------------LQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEA 513
Query: 760 YGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLE-LEKEIKCL 818
E EVSE S +V++ S + ++ F + K L L E+K
Sbjct: 514 QNRTGEADREVSEIS----IVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEA 569
Query: 819 QEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNL 878
QEE +L+ + +VL +KE+++++ E A ++MK E T Q+
Sbjct: 570 QEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIA----PIKMKVFLEDT---GQDF 622
Query: 879 LIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSV 938
+ E S + EKE+ E + R +E I L D+ + S
Sbjct: 623 PLMPNEESSLPAV-----EKEQA-------------STEHQSRTSEEISLNDAGVELKST 664
Query: 939 KND---PLSSVKEL----EEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTV 991
K D LS+V ++ ++++E L+ + E E +K + + +K LD KE +
Sbjct: 665 KQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEI---YEKNLDEKAKEISNL 721
Query: 992 KEELESLRSEKDQLSASM------RDLIQGAESYKNLLLEYEKQSEQLDV---EKERANN 1042
+ +E + D S++ RD + +++ E Q +QL++ E ER
Sbjct: 722 NQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRR 781
Query: 1043 FEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKE 1102
++ + L + +I + ++D+ +IE LQ+ +++Q E ++ + +
Sbjct: 782 LDYESQTAHDNLLTEQIHSLSIEAKSKDV--KIEVLQNELDDVQLQFSE----QSTLIRS 835
Query: 1103 LEAEKLQKEQKIKEHATTV----NELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLM 1158
L+++ KE ++ E A V +++EEL L +++ ++ K M +L L KK +T
Sbjct: 836 LQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITK-MDQLLLEKKRDVETLQQ 894
Query: 1159 NMEIADYE--RLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEE 1216
+E D + + + +K+ N + L EIK K++ L + + V++ E
Sbjct: 895 TIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE 954
Query: 1217 KNTKIKQLLVKTKKELADSKQAETDHLILQAS-LKGELEASQQQVEVYKIQLAEITSEKH 1275
++ +KQ E++ + Q + L + LK E E +++++ I E+
Sbjct: 955 VSSGLKQ----NYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVS 1010
Query: 1276 KIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQK 1335
++ E L ++ ++ + + ++E+ + + VTS+ + ++ + + +++
Sbjct: 1011 RLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKE 1070
Query: 1336 NKSMS-QAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHN 1394
+ + + E E + L+ Q+ LQD N + + +E+ Q+ L+ +
Sbjct: 1071 VELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNT 1130
Query: 1395 --------KMLQETV--------SKE---AELREKLCSIQSENMMMKSEHTQTVSQLTSQ 1435
+++ETV S E EL EK+ +++ E ++ + + LTS+
Sbjct: 1131 DASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEA---LTSR 1187
Query: 1436 NEVLRNSFRDQVRHLQE-----------------EHRKTVETLQQQLSKMEAQ------- 1471
+L+ + +++ RHL+E E K E + QL +++ Q
Sbjct: 1188 KAILKKA-QEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDG 1246
Query: 1472 -LFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSAS 1530
L + + S ++ L E+ +T P+L+ + + + + +S +
Sbjct: 1247 KLPSTDQQESCSSTPGLEEPLFKATEQHHTQ-PVLESNLCPDWPSHSEDASALQGGTSVA 1305
Query: 1531 TYTQSLEQL-LNSPETKLEPPLWHAEFTKE-----ELVQKLSSTTKSADHLNGLLRETEA 1584
L+++ E +L+ +E TK+ +L ++++ + L + E E
Sbjct: 1306 QIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEV 1365
Query: 1585 TNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPG--SERERLLPVI 1642
L ++++ + +I LE +E + L+ L + + + G SE+E L I
Sbjct: 1366 HAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKI 1425
Query: 1643 NT 1644
T
Sbjct: 1426 QT 1427
Score = 141 bits (355), Expect = 6e-33
Identities = 270/1391 (19%), Positives = 574/1391 (41%), Gaps = 208/1391 (14%)
Query: 406 SELAGLNKQFCYTVEQHNREVQSLK-----EQHQKEISELNETFLSDSEKEKLT----LM 456
S L+GL + + + Q+++ E HQ+ E N T D + E+L L+
Sbjct: 3 SRLSGLANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQ-ERLAYAEQLV 61
Query: 457 FEIQGLKEQCENLQQEKQEAILNYESLREI-MEILQTELGESAGKISQEFESMKQQQASD 515
E++ + Q + Q+K EA+ + ++ L+ +++ E MK Q +
Sbjct: 62 VELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTV 121
Query: 516 VHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSL 575
+ Q + E ++ KL ++EL+ L+ + Q + +
Sbjct: 122 LPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTE 181
Query: 576 SQRDTMLKELEGKINSLTEEKDDFINKLKN--SHEEMDNFHKKCEREERLILELGKKVEQ 633
+ M+K+ +EK++FI+ L+ S + + ++ RE+ E ++ +
Sbjct: 182 MEEFVMMKQQ-------LQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHE 234
Query: 634 T--------IQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA 685
+E++QK+ L LEE + Q ++ L ++ + ++LS
Sbjct: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQ 294
Query: 686 EVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHIT--QLEKKLQLMVEEQDNLNK 743
+++ + E+N L + + + ++ L + E + + ++ L++++ ++E+ + +
Sbjct: 295 QLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQ 354
Query: 744 LLENEQVQKLFVKTQLYGFLKEMGSEV-SEDSEEKDVVNVLQAVGESLAKINEEKCNLAF 802
+ + ++ + ++E S + S +++ + A+ + +K+ ++K A
Sbjct: 355 AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAV 414
Query: 803 QRDEKVLELEKEIK-------------CLQEESVVQCEELKSLLRD-----YEQEKVLLR 844
Q + + +LE +++ LQ+ + + E+ L+
Sbjct: 415 QSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQ 474
Query: 845 KELEEIQSEKEAL---QSDLLEMKNANEK-----TRLENQNLLIQVEEVSQTCSKSEIHN 896
K + E+++EK AL +L E+K NEK T LE QN + + S +I N
Sbjct: 475 KRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIAN 534
Query: 897 EK------------EKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLS 944
++ E F ++H+ L LL E+++ + E+ LK L + + D
Sbjct: 535 KRSSSAEESGQDVLENTFSQKHKELSVLL--LEMKEAQEEIAFLKLQLQGKRAEEAD--- 589
Query: 945 SVKELEEKIENLEKECKEKE-EKINKIKLVAV-------------------KAKKELDSS 984
E ++ +KE K+ E E I IK+ +KE S+
Sbjct: 590 -----HEVLD--QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQAST 642
Query: 985 RKETQTVKE--------ELESLRSEKDQLSASMRDLIQ----GAESYKNLLLEYEKQ--- 1029
+++T +E EL+S + + D+ +++ D+ Q E K+ +LE E
Sbjct: 643 EHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHK 702
Query: 1030 -----SEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIE------TL 1078
+ LD + + +N IE+ + N++ ++ + + LL++++ L
Sbjct: 703 AQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTEL 762
Query: 1079 QSNAKLLEVQILEVQRAKA-----------MVDKELEAEKLQKEQKIKEHATTVNELEEL 1127
++ K LE+ + E +R + ++ +++ + ++ + K + NEL+++
Sbjct: 763 RAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDV 822
Query: 1128 QVQLQKE-------KKQLQKTMQEL----ELVKKDAQQTTLMNMEIADYERLMKELNQKL 1176
Q+Q ++ + QLQ E+ E V+ + + ++ ++ E + +++Q L
Sbjct: 823 QLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLL 882
Query: 1177 TNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEK-------NTKIKQLLVKTK 1229
K +E L+Q I+++ Q+ + + + VQ EEK T +QL + ++
Sbjct: 883 LEKKRDVETLQQ--TIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSR 940
Query: 1230 KELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQ 1289
E A +Q E D+ + + LK + ++ K +L +H+ + LK EQ +
Sbjct: 941 AEEAKKEQVEEDNEV-SSGLKQNYDEMSPAGQISKEEL------QHEF-DLLKKENEQRK 992
Query: 1290 RTLSA-------YQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQA 1342
R L A QRV+ L+EE K E E + V + ++NK S+
Sbjct: 993 RKLQAALINRKELLQRVSRLEEELANLKDES---KKEIPLSETERGEVEEDKENKEYSEK 1049
Query: 1343 ETEGAKQERE-HLEMLIDQLKIKLQDSQNNLQINVSELQTLQS----EHDTLLERHNK-- 1395
QE E +L+ I + +++LQ + +L+ ++ + Q+ + TL ++ N+
Sbjct: 1050 CVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQID 1109
Query: 1396 MLQETVSKEAELREKLCSIQS-----ENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHL 1450
+LQ +S+ + +KL + + +++ + E T +E + +++ L
Sbjct: 1110 LLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILAL 1169
Query: 1451 QEEHRKTVETLQQQLSKMEAQLFQL-KNEPTTRSPVSSQQSLKN---------LRERRNT 1500
++E + + LQ+ L+ +A L + + E R + Q+ N +E N
Sbjct: 1170 EKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENI 1229
Query: 1501 DLPLLDMHTVTRE--EGEGMETTDTESVSSASTYTQSLEQLLNSPETK--LEPPLWHAEF 1556
L + RE +G+ T ES SS + L + T+ LE L
Sbjct: 1230 GDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWP 1289
Query: 1557 TKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRR-----LERNQEREK 1611
+ E L T S + L+E EA L ++ SE+ + + ++ K
Sbjct: 1290 SHSEDASALQGGT-SVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINK 1348
Query: 1612 SAANLEYLKNV 1622
+E LK V
Sbjct: 1349 QGLEIESLKTV 1359
Score = 70.9 bits (172), Expect = 1e-11
Identities = 174/922 (18%), Positives = 363/922 (39%), Gaps = 168/922 (18%)
Query: 853 EKEALQSDLLEMKNANEKTRLEN----QNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHEN 908
+ E Q +E N ++ E + L+++++++ + K +K++ +E +
Sbjct: 31 DPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIR--QKDVQLQQKDEALQEERKA 88
Query: 909 LKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKIN 968
+++ +L +A+L L + + + L + + EE++ +K E+E +I
Sbjct: 89 ADNKIKKLKLH-AKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIE 147
Query: 969 KIKLVAVKAKKELDSSRK------------ETQTVKEELESLR---SEKDQLSASMRDLI 1013
KIK ++ K+EL S+ + ++ T EE ++ EK++ ++++ +
Sbjct: 148 KIK-HKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQL 206
Query: 1014 ---QGAESYKNLLLEYEKQSE---------------QLDVEKERANNF--------EH-- 1045
Q ++ + ++ E + + E Q DVE E EH
Sbjct: 207 SQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEE 266
Query: 1046 ------RIEDLTRQ------LRNSTL--QCETINSDNEDLLARIETLQSNAK-LLEVQIL 1090
++ DL +Q RN L Q + + +++ L +ET + +K LLE L
Sbjct: 267 SLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMEL 326
Query: 1091 EVQRAKAMVDKELEAEKLQKE-----QKIKEHATTVNELEELQVQLQKEKK--------- 1136
EV +++L LQ+E ++ ++ ELE L+++ K
Sbjct: 327 EV------AERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSH 380
Query: 1137 --QLQKTMQELEL---VKKDAQQTTLM--NMEIADYERLMKELNQKLTNKNNKIEDLEQE 1189
LQKT QEL+ KD L N + + +++L +L K+ +I
Sbjct: 381 ILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNR 440
Query: 1190 IKIQKQK---------------QETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELAD 1234
+ +Q+ + Q +E I SLQ V + E + + ++ ++ A+
Sbjct: 441 LPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAE 500
Query: 1235 SKQAETDHLILQASLK-GELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLS 1293
+++ + +L+A + GE + ++ + I +S + + L+ + Q + LS
Sbjct: 501 NEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELS 560
Query: 1294 AYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMS------------- 1340
+ QEE K + +E ++V +KQ + + ++
Sbjct: 561 VLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQ 620
Query: 1341 ------------------QAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTL 1382
QA TE Q R E+ ++ ++L+ ++ + ++S + +
Sbjct: 621 DFPLMPNEESSLPAVEKEQASTE--HQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDI 678
Query: 1383 QSEHDTLLERHNKMLQETVSKEAELR-EKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRN 1441
H LER + E EL K I +N+ K++ ++QL + + +
Sbjct: 679 GQCHQDELERLKSQI-----LELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNAD 733
Query: 1442 SFRDQVRHLQEEHRKTVETLQQ--QLSKMEAQLFQL-----KNEPTTRSPVSSQQSLKNL 1494
+ L EE + + +++ ++++ AQ+ QL + E R SQ + NL
Sbjct: 734 NNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNL 793
Query: 1495 RERRNTDLPLLDMHTVTREEGEGMETTDTE-SVSSASTYTQSLEQLLNSPETKL---EPP 1550
+ L + + E E D + S ST +SL+ L + E+++
Sbjct: 794 LTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAER 853
Query: 1551 LWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEI---------R 1601
+ H EEL Q LS ++ LL E + L + I+ ++ +
Sbjct: 854 VRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEK 913
Query: 1602 RLERNQEREKSAANLEYLKNVL 1623
++ N+E+ ++ LK L
Sbjct: 914 MVQLNEEKFSLGVEIKTLKEQL 935
>gi|211059431 RANBP2-like and GRIP domain containing 4 [Homo sapiens]
Length = 1758
Score = 224 bits (572), Expect = 4e-58
Identities = 151/325 (46%), Positives = 194/325 (59%), Gaps = 33/325 (10%)
Query: 1361 LKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMM 1420
++ KLQD ++ + E +T Q E D+L+ H VS+ + RE C + ++
Sbjct: 1446 VRFKLQDVADSFKKIFDEAKTAQ-EKDSLITPH-------VSRSSTPRESPCGKIAVAVL 1497
Query: 1421 MKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTV----------ETLQQQLSKMEA 1470
E T+ + + ++V + +V E K V E++++ S ++
Sbjct: 1498 --EETTRERTDVIQGDDVADAASEVEVSSTSETTTKAVVSPPKFVFGSESVKRIFSSEKS 1555
Query: 1471 QLFQLKNEPTTRS--PVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSS 1528
+ F N T S S SLK+ ++ V ++ E + +D E S
Sbjct: 1556 KPFAFGNSSATGSLFGFSFNASLKSNNSETSSVAQSGSESKVEPKKCELSKNSDIEQSSD 1615
Query: 1529 ASTYT---------QSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLL 1579
+ S+ +PE EPPLWHAEFTKEELVQKLSSTTKSADHLNGLL
Sbjct: 1616 SKVKNLSASFPMEESSINYTFKTPEK--EPPLWHAEFTKEELVQKLSSTTKSADHLNGLL 1673
Query: 1580 RETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLL 1639
RE EAT+A+LMEQIKLLKSEIRRLERNQE+E+SAAN+E+LKNVLLQFIFLKPGSERERLL
Sbjct: 1674 REAEATSAVLMEQIKLLKSEIRRLERNQEQEESAANVEHLKNVLLQFIFLKPGSERERLL 1733
Query: 1640 PVINTMLQLSPEEKGKLAAVAQGEE 1664
PVINTMLQLSPEEKGKLAAVAQGEE
Sbjct: 1734 PVINTMLQLSPEEKGKLAAVAQGEE 1758
>gi|221307607 RANBP2-like and GRIP domain containing 3 [Homo sapiens]
Length = 1758
Score = 218 bits (556), Expect = 3e-56
Identities = 150/325 (46%), Positives = 192/325 (59%), Gaps = 33/325 (10%)
Query: 1361 LKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMM 1420
++ KLQD ++ + E +T Q E D+L+ H VS+ + RE C + ++
Sbjct: 1446 VRFKLQDVADSFKKIFDEAKTAQ-EKDSLITPH-------VSRSSTPRESPCGKIAVAVL 1497
Query: 1421 MKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTV----------ETLQQQLSKMEA 1470
E T+ + + ++V + +V E K V E++++ S ++
Sbjct: 1498 --EETTRERTDVIQGDDVADAASEVEVSSTSETTTKAVVSPPKFVFGSESVKRIFSSEKS 1555
Query: 1471 QLFQLKNEPTTRS--PVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSS 1528
+ F N T S S LK+ ++ V ++ E + +D E S
Sbjct: 1556 KPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELSKNSDIEQSSD 1615
Query: 1529 AS---------TYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLL 1579
+ T S+ +PE EPPLW+AEFTKEELVQKLSSTTKSADHLNGLL
Sbjct: 1616 SKVKNLSASFPTEESSINYTFKTPEK--EPPLWYAEFTKEELVQKLSSTTKSADHLNGLL 1673
Query: 1580 RETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLL 1639
RE EATNA+LMEQIKLLKSEIRRLERNQE+E SAAN+E+LKNVLLQFIFLKPGSERERLL
Sbjct: 1674 REIEATNAVLMEQIKLLKSEIRRLERNQEQEVSAANVEHLKNVLLQFIFLKPGSERERLL 1733
Query: 1640 PVINTMLQLSPEEKGKLAAVAQGEE 1664
PVINTMLQLS EEKGKLAAVAQGEE
Sbjct: 1734 PVINTMLQLSLEEKGKLAAVAQGEE 1758
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 216 bits (551), Expect = 1e-55
Identities = 366/1752 (20%), Positives = 716/1752 (40%), Gaps = 197/1752 (11%)
Query: 11 SPATPGTGKSKLE-TLPKEDLIKFAK-------KQMMLIQKAKSRCTEL----EKEIEEL 58
SPA P T +S+LE TL K + ++ K + L+ + E+ E++++E
Sbjct: 1057 SPAAP-TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1115
Query: 59 RSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKM-GDAH 117
++ P T + KA ++L A +AE +Q ++ ++ QEV + + + G+
Sbjct: 1116 QAVPATLPELEATKASLKKLRA----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1171
Query: 118 KELEQSHINYV-----------------KEIENLKNELMAVRSKYSEDKANLQ---KQLE 157
E+E+ +E+E L +L R A LQ ++ E
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1231
Query: 158 EAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVT 217
+ L S+ ++ Q E + L EEIE+ EE + ++ ++A D + + VT
Sbjct: 1232 QIQAMPLADSQAVREQLRQE---QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288
Query: 218 QLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELK 277
+ S + + S E ++Q + EL K + ++ E +
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-E 1347
Query: 278 ENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHL 337
E L +Q A E+ + E LE R+ A Q + +E ++Q + E+V
Sbjct: 1348 ERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 338 EDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQ 397
E+ + + Q +++E + L+ E + Q K E +I E + Q
Sbjct: 1405 EEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQ-AKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 398 GCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF 457
+E + + G + + E ++ K Q Q+E L +S++++ +
Sbjct: 1461 ---LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516
Query: 458 EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFE-SMKQQQASDV 516
+K + E +EKQ A+ E LR E + L ++ + +++ + +++ Q S
Sbjct: 1517 LASRVKAEAE-AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 517 HELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLS 576
ELQ K R +F EK A LE L + V +L + ++ +
Sbjct: 1576 AELQSK-RASFAEKTAQLE---------RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 577 QRDTMLKELEGKINS---LTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQ 633
+ + L+ + K N L + ++ + + E + ++ ERE R GK EQ
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR---RRGKAEEQ 1682
Query: 634 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV-------QMKVLSEDKEVLSAE 686
++ EQ++ + E T +++ +Q+L +L Q ++L E+ L E
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 687 VKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLE 746
+ ++ +L +E ++ ++EV L+ K + T EK Q + E +L E
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS-EKSKQRLEAEAGRFRELAE 1801
Query: 747 NE-QVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRD 805
+++ L + + L E + E+ + L A+GE+ E + L
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---- 1857
Query: 806 EKVLELEKEIKCLQEESVVQCEELKSLLR----DYEQEKVLLRKELEEIQSEKEALQSDL 861
EK E E+ ++ L E+ Q L+ D E+ LRK + ++ L D
Sbjct: 1858 EKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1916
Query: 862 LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIH--------NEKEKCFIKEHENL---- 909
L ++ ++E + L ++ K+E+ N ++ KE L
Sbjct: 1917 LR-----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1971
Query: 910 -KPLLEQKELRDRRAELILLKDSLAKSPSVKNDP--LSSVKELEEKIENLEK-ECKEKEE 965
+ L ++E R R AE + K A+ + + L V+ L+ K+E + + ++E
Sbjct: 1972 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2031
Query: 966 KINKIKLVAVKAKKELDSSRK--------ETQTVKEELESLRSEKDQLSASMRDLIQGAE 1017
+++L A+K L + K + Q +++ L+ +S DQL + AE
Sbjct: 2032 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2091
Query: 1018 SYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIET 1077
+ ++ E+++ Q + E A + E+ + + E + + E AR
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2151
Query: 1078 LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQ 1137
+ A R K D E+E K EQ +++ A EL L++QL++ Q
Sbjct: 2152 AEQAAL----------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2201
Query: 1138 LQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQ 1197
+EL+ +K +A + ++ + ++ ++L+ +IE E I + K
Sbjct: 2202 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE-AENRALILRDKD 2260
Query: 1198 ET---LQEEITSLQSSVQQYE------EKNTKIKQLL---VKTKKELADSKQAETDHLIL 1245
T LQEE ++ ++ ++ +++QL + ++ LA+ E +
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320
Query: 1246 QAS-LKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQE 1304
+A+ LK E E QQQ E+ + Q + +K ++ + L + QRTL A +QR
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR------ 2374
Query: 1305 ECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL-KI 1363
Q +++E E K+RV + +++ ++AE E A++ R+ E + ++L +
Sbjct: 2375 --------QLEMSAEAERLKLRV-----AEMSRAQARAE-EDAQRFRKQAEEIGEKLHRT 2420
Query: 1364 KLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS 1423
+L + + E+Q QS+HD + L+E +++ +EKL +++ + +KS
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDA------ERLREAIAELEREKEKL-QQEAKLLQLKS 2473
Query: 1424 EHTQTV--SQLTSQNEVLRNSFRDQ-------VRHLQEEHRKTVETLQQQLSKMEAQLFQ 1474
E QTV QL + + L+ SF + R +++E K + Q +++K + QL +
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ-QLRE 2532
Query: 1475 LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQ 1534
+ + Q+ + ++ E R + +EE + +E + + Q
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2592
Query: 1535 SLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAI------ 1588
L + L E + L H+E V + D L+G E E ++
Sbjct: 2593 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2652
Query: 1589 -----LMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVL-----LQFIFLKPGSERERL 1638
L E L E++RL + A E +++ L + + LK +E+ +
Sbjct: 2653 VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2712
Query: 1639 LPVINTMLQLSP 1650
+ L LSP
Sbjct: 2713 YAALQRQL-LSP 2723
Score = 145 bits (365), Expect = 4e-34
Identities = 355/1856 (19%), Positives = 712/1856 (38%), Gaps = 335/1856 (18%)
Query: 7 DGVASPATPGTGKSKLETLPKE--DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVT 64
+G SPAT G + L L + L+ +K ++ ++ S KE+ L K
Sbjct: 579 EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE 638
Query: 65 EGTGDI------IKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMG---- 114
E D + A E AL+ E L LK++ IK Q D + +
Sbjct: 639 EVGFDWSDRNTNMTAKKESYSALMRE--------LELKEKKIKELQNAGDRLLREDHPAR 690
Query: 115 ------------------------DAHKELEQSHINYVKEIENLKNELM----AVRSKYS 146
+AH + ++ + ++ + +L A+R KYS
Sbjct: 691 PTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 750
Query: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
D++ +LE+ + + EQL + K + + +++P + + L
Sbjct: 751 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLL 810
Query: 207 ATTDEKKETVT-----QLQNIIEANSQHYQKNINSLQEELLQ----LKAIHQEEVKELMC 257
A D K+ VT + Q + A H++ +S E + L +E +E +
Sbjct: 811 AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 870
Query: 258 QIEASAKEHEAEINKLNELKENL--VKQCEASEKNIQKKYECELENLRKATSNANQDNQI 315
++EA +H+A + ++L ++ + ++ +++Q L R Q +
Sbjct: 871 RLEA---QHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR-TLKPEEQRQAL 926
Query: 316 CSILLQENTFV-----------------EQVVNEKVKHLEDTLKELESQH---------- 348
S+ L F+ E+ H + L+ LE
Sbjct: 927 HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 986
Query: 349 SILKD--------EVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKIN------------ 388
S LKD E ++ L+L L+ + + E++ + ++
Sbjct: 987 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1046
Query: 389 -ELLLAKEEQGCVIEKLKSE-------------LAGLNKQFCYTVEQHNREVQSLKE--- 431
E +LA E L+SE L+ + + T+ R Q +E
Sbjct: 1047 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1106
Query: 432 QHQKEISE-------LNETFLSDSEKEKLTLMFEIQ------------GLKEQCENLQQE 472
H++++ E L E + + +KL E Q G +E E LQQ
Sbjct: 1107 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1166
Query: 473 KQEAILNYESLREIM--------------EILQTELGESAGKISQEFES----------- 507
E + E RE + ++ Q EL + ++ ES
Sbjct: 1167 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1226
Query: 508 ---MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNL 564
+Q QA + + Q +R ++ ALLE + R EK+ Q + N IK+
Sbjct: 1227 RRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1282
Query: 565 QEKNGVYLLSLS-------------------QRDTMLKELEGKINSLTEEKDDFINKLKN 605
+ + Y L Q L+ ++ +LT + FI++
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342
Query: 606 SHEEMDNF--HKKCEREERL-----ILELGKKV--------EQTIQYNSELEQKVNELTG 650
EE + ++ E ERL LE +++ Q + EL+Q++ E
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 651 GLEETLKEKDQNDQKLEKLMVQMKVLSE-DKEVLSAEVKSLYEENNKLSSEKKQLSRDLE 709
EE + Q + +++ + Q++ SE + + + + ++ ++ E + + LE
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 710 VFLSQK-----EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLK 764
Q+ E L+ + E + + EE + L + +++E +K + +L +K
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522
Query: 765 EMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVV 824
+E ++ LQA+ E + E + L E+ +++ ++ Q +
Sbjct: 1523 ------AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576
Query: 825 QCEELKSLLRDYEQEKVLLRKELEE-------IQSEKEALQSDLLEMKNANEKTRLENQ- 876
EL+S + ++ L + L+E ++ E E E + A E+ E +
Sbjct: 1577 ---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 877 ---------NLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELIL 927
L +Q EEV+Q S ++ EK+K + + E++ +R R L
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----L 1689
Query: 928 LKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
+ L K + E+++ L E ++ E++ ++ + ++E ++ ++
Sbjct: 1690 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749
Query: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
Q ++ EL +R+E + L AS + + S EK ++L+ E R
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEAEAGRFRELAEEA 1803
Query: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIETL--QSNAKLLEVQILEVQRAKAMVDKELEA 1105
L + Q + D A E + + A + E L+ + A+ +KE E
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 1106 EKLQK------------EQKIKEHATTVNE-LEELQ----VQLQKEKKQLQKTMQELELV 1148
E+L++ E++ +H + E L +L+ +L+++K ++ T+++ V
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 1149 KKD-AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ-EIKIQKQKQETLQEEITS 1206
+++ A L EL + +N + + EQ E++ +Q+Q +EE
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE--- 1980
Query: 1207 LQSSVQQYEEKNTKIKQLLVKTKKELADSKQA--ETDHLILQASLKGELEASQQQVEVYK 1264
++ E ++++ L ++ K A E + L + L +Q +
Sbjct: 1981 -----RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035
Query: 1265 IQLAEITSEK-----HKIHEHLKTSAEQH-QRTLSAYQQRVTALQEECRAAK-----AEQ 1313
+QLA+ ++K K H EQ Q+TL Q + L+ E AA+ AE+
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 1314 ATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ 1373
A V +E E+ + R V + ++ K ++ + + Q + E L + + Q++ Q
Sbjct: 2096 ARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE---QEAARRAQ 2151
Query: 1374 INVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLT 1433
+ L+ Q+ D +E+H K ++T+ ++A++ ++L +++ + + +++H + +
Sbjct: 2152 AEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEETDHQKNLLDEE 2208
Query: 1434 SQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKN 1493
Q + + R EE +V ++LSK++A++ E R+ +
Sbjct: 2209 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-----EAENRALI-------- 2255
Query: 1494 LRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWH 1553
LR++ NT L +EE E M+ E + S Q +L E L
Sbjct: 2256 LRDKDNTQRFL-------QEEAEKMKQV-AEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307
Query: 1554 AEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQER 1609
AE +E +Q + T+ +A +L +Q +L + + RRL+ ++E+
Sbjct: 2308 AEKMLKEKMQAVQEATR-----------LKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Score = 133 bits (335), Expect = 1e-30
Identities = 333/1795 (18%), Positives = 703/1795 (39%), Gaps = 298/1795 (16%)
Query: 109 SVTKMGDAHKELEQSHINYVKEIENLKNE----LMAVRSKYSEDKANLQKQLEEAMNTQL 164
SV +H+ L QS + +IE +++ A R Y + L Q + +N+
Sbjct: 550 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSS- 608
Query: 165 ELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIE 224
+L+ + V +E+ + EE++ + + KKE+ + L +E
Sbjct: 609 --KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 666
Query: 225 ANSQHYQKNINSLQEELLQ-----------LKAIHQEE---VKELMCQIEASAKEHEAEI 270
+ K + + + LL+ +A Q + + +L C IEA KE+ A
Sbjct: 667 LKEKKI-KELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 725
Query: 271 NKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVV 330
++++E Q + ++ +++KY C+ R AT +D LLQ+ ++ +
Sbjct: 726 QFFSDVRE-AEGQLQKLQEALRRKYSCD----RSATVTRLED------LLQDAQDEKEQL 774
Query: 331 NEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINEL 390
NE HL K ++ + + +L L + + E + D + +
Sbjct: 775 NEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGD---ECQLV 831
Query: 391 LLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQS----LKEQHQKEISELNETFLS 446
A+ V+ SE A C+ V N+E Q L+ QHQ ++ ++ +
Sbjct: 832 GPAQPSHWKVLSSSGSEAA--VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 889
Query: 447 -DSEKEKLTLMFEIQGLKE---------QCENLQQEKQEAILNYES-LREIME------- 488
S +L ++Q ++ + E +Q L+Y++ LR+ +
Sbjct: 890 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 949
Query: 489 ---ILQTELGESAGKISQEFESMK---------QQQASDVHELQQKLRTAFT-------- 528
+ + E G + Q +S++ Q+ S++ +++ +L T
Sbjct: 950 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1009
Query: 529 --EKDALLETVNRL--------------------QGENEKLLSQQELVP-------ELEN 559
+K+ E R+ E EK+L+ E P ELE
Sbjct: 1010 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1069
Query: 560 TIKNLQE---KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDF----------------- 599
T+ L++ + +YL L +++ +G L ++
Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1129
Query: 600 --INKLKNSHEEMDNFHKKCEREERLILELGKKVEQTI-QYNSELE---QKVNELTGGLE 653
+ KL+ E E R E+G++++Q + + E+E ++V +L +
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189
Query: 654 ETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLS 713
L + D ++LE+L Q++ E + L A ++ ++ + S+ + L
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1249
Query: 714 QKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGF---LKEMGSEV 770
Q++ L E I + +K++ +++ ++Q + K QL K+ +
Sbjct: 1250 QEQ--ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1307
Query: 771 SEDSEEKDVVNV--------------LQAVGESLAKINEEKCNLAFQRDEK--------- 807
+S ++ V++ ++ + E+L ++ EE+ QR E+
Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1367
Query: 808 VLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE-EIQSEKEALQSDLLEMKN 866
LE ++++ ++ Q E L+ QE+V+ R+E + Q +K ++Q +L +++
Sbjct: 1368 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1427
Query: 867 ANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRR---- 922
++E ++ +K+ E+ ++ E ++ + Q E +R+
Sbjct: 1428 SSE----------------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1471
Query: 923 -AELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKL-VAVKAKKE 980
EL L+ ++ + K ++ +E+ E L ++ +++ ++ + ++ +A + K E
Sbjct: 1472 EGELQALRARAEEAEAQK-------RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524
Query: 981 LDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERA 1040
+++R E Q + LE LR + ++ +R + LE ++S + +++ +RA
Sbjct: 1525 AEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583
Query: 1041 NNFEHRIEDLTRQLRNSTL-----------------QCETINSDNEDLLARIETLQSNAK 1083
+F + L R L+ + + E + E L R + + A
Sbjct: 1584 -SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
Query: 1084 LLEVQILEVQRAKAMVDKELEAEKLQKEQ------KIKEHATTVNELEELQVQLQK---E 1134
L +Q EV + K++ E E +K + E+ K +E A EL E +++ Q+ E
Sbjct: 1643 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1702
Query: 1135 KKQLQKTMQELELVKKDA------QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ 1188
Q+ E EL++ A QQ L+ E+A +R QK ++ +
Sbjct: 1703 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1762
Query: 1189 EIKIQKQKQETLQEEITSL-QSSVQQYEEKNTKIKQLL------------VKTKKELAD- 1234
E+++ + +EE S + S Q+ E + + ++L K +++LA+
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 1235 --SKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTL 1292
++Q +L L EA++ + E +I L E +E ++ + A Q +R
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEA-EIALKEKEAENERLRRLAEDEAFQRRRLE 1881
Query: 1293 SAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMS----QAETEGAK 1348
Q ++E R A+ +A+ SE E K V + L+Q++ +A E A
Sbjct: 1882 EQAAQHKADIEE--RLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938
Query: 1349 QEREHLEMLIDQLKIKLQD---SQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA 1405
+ LE+ + +++ +D S+ ++ + + L +E + + +Q++++ E
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998
Query: 1406 E-LREKLCSIQS-ENMMMKSEHTQTVSQLTSQNEVLRNSFRDQV--RHLQEEHR------ 1455
E R++ +++ E + K E + + + Q + + + LQ E +
Sbjct: 1999 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2058
Query: 1456 -KTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ-------------QSLKNLRERRNTD 1501
+ + LQQ L + ++ L QL+ E + + QS + + E
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 1502 LPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEEL 1561
+ + E E+ A+ Q+ + L + H +F ++ L
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 1562 VQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERN--------------- 1606
QK + + L L ET+ +L E+++ LK+E R
Sbjct: 2179 RQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2237
Query: 1607 QEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQ 1661
+E K A +E L+ L+ +R L ++ EE +L+ AQ
Sbjct: 2238 EELSKLKARIEAENRALI----LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2288
Score = 43.1 bits (100), Expect = 0.002
Identities = 204/1030 (19%), Positives = 381/1030 (36%), Gaps = 177/1030 (17%)
Query: 721 KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV 780
K H+ LE++ QL E + E +Q++ K Q+ L E ++ + DV
Sbjct: 372 KLHVAILEREKQLRSEFE-------RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR 424
Query: 781 NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840
L A G+ + E + +L + D + L +++ L++ Q E++ + +
Sbjct: 425 --LLAAGKVPQRAGEVERDLD-KADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERL 481
Query: 841 VLLRKELE---EIQSEKEALQSDLLEMKNANEKTRLEN------QNLLIQVEEVSQTCSK 891
V +R E + A Q + +++ + LE+ Q+LL VEE
Sbjct: 482 VAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG 541
Query: 892 SE--IHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKEL 949
+E + + + H L +E+ + RA D SP+ + + L
Sbjct: 542 AEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR----SDEGQLSPATRGAYRDCLGRL 597
Query: 950 EEKIENLEKECKEKEEKINKIKLVAVKAKKELD-SSRKETQTV----KEELESLRSEKDQ 1004
+ + L K + + + A KEL + KE + V + ++ ++K+
Sbjct: 598 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 657
Query: 1005 LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1064
SA MR+L E + + E + ++L E A + + + LQ
Sbjct: 658 YSALMREL----ELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQ---- 709
Query: 1065 NSDNEDLLARIET-LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123
L IE L+ NA + +V+ A+ + K EA L+++ + + TV
Sbjct: 710 ------LCCCIEAHLKENAAYFQF-FSDVREAEGQLQKLQEA--LRRKYSC-DRSATVTR 759
Query: 1124 LEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN--------------MEIADYERLM 1169
LE+L Q EK+QL + L + K A+ + + + DY+++
Sbjct: 760 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE 819
Query: 1170 KELNQ---------------KLTNKNNKIEDLEQEIKIQKQKQETLQEEITSL----QSS 1210
+++ K+ + + + + + QE +T L Q+
Sbjct: 820 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 879
Query: 1211 VQQYEEKNTKIKQLL----------------VKTKKELADSKQAETDH---LILQASLKG 1251
V + + + +K LL + T + L +Q + H L QA L+
Sbjct: 880 VTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRD 939
Query: 1252 ELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQ------EE 1305
+A E + E S H ++ L S EQ + S Q+ ++ L+ E
Sbjct: 940 SQDAGGFGPEDRLMAEREYGSCSHH-YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEA 998
Query: 1306 CRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKL 1365
C + + + E + + +QQK +QAE EG + L +++
Sbjct: 999 CETRTVHRLRLPLDKEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALP 1054
Query: 1366 QDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEH 1425
+ S TL+SE + L + L++ S A EKL +I
Sbjct: 1055 EPS--------PAAPTLRSELELTLGK----LEQVRSLSAIYLEKLKTI----------- 1091
Query: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485
+ + EVLR EE K + + L ++EA
Sbjct: 1092 SLVIRGTQGAEEVLR---------AHEEQLKEAQAVPATLPELEA--------------- 1127
Query: 1486 SSQQSLKNLRERRNTDLP----LLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541
++ SLK LR + P L D +E GE ++ E + + + QLL
Sbjct: 1128 -TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1186
Query: 1542 SPETKL-EPPLWHAEFTKEELVQKLSSTTKSADHLNGLL----RETEATNAILMEQIKLL 1596
+ L + + E E+L ++L +SAD L L R E A+ + + +
Sbjct: 1187 RWQAVLAQTDVRQREL--EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244
Query: 1597 KSEIRRLER-NQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSP-EEKG 1654
+ ++R+ + +E E+ +E + Q+I + ++ L ++ QL P
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYI----NAIKDYELQLVTYKAQLEPVASPA 1300
Query: 1655 KLAAVAQGEE 1664
K V G E
Sbjct: 1301 KKPKVQSGSE 1310
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 216 bits (551), Expect = 1e-55
Identities = 366/1752 (20%), Positives = 716/1752 (40%), Gaps = 197/1752 (11%)
Query: 11 SPATPGTGKSKLE-TLPKEDLIKFAK-------KQMMLIQKAKSRCTEL----EKEIEEL 58
SPA P T +S+LE TL K + ++ K + L+ + E+ E++++E
Sbjct: 1061 SPAAP-TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1119
Query: 59 RSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKM-GDAH 117
++ P T + KA ++L A +AE +Q ++ ++ QEV + + + G+
Sbjct: 1120 QAVPATLPELEATKASLKKLRA----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1175
Query: 118 KELEQSHINYV-----------------KEIENLKNELMAVRSKYSEDKANLQ---KQLE 157
E+E+ +E+E L +L R A LQ ++ E
Sbjct: 1176 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1235
Query: 158 EAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVT 217
+ L S+ ++ Q E + L EEIE+ EE + ++ ++A D + + VT
Sbjct: 1236 QIQAMPLADSQAVREQLRQE---QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1292
Query: 218 QLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELK 277
+ S + + S E ++Q + EL K + ++ E +
Sbjct: 1293 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-E 1351
Query: 278 ENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHL 337
E L +Q A E+ + E LE R+ A Q + +E ++Q + E+V
Sbjct: 1352 ERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAEREAKELQQRMQEEVVRR 1408
Query: 338 EDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQ 397
E+ + + Q +++E + L+ E + Q K E +I E + Q
Sbjct: 1409 EEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQ-AKARQAEAAERSRLRIEEEIRVVRLQ 1464
Query: 398 GCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF 457
+E + + G + + E ++ K Q Q+E L +S++++ +
Sbjct: 1465 ---LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1520
Query: 458 EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFE-SMKQQQASDV 516
+K + E +EKQ A+ E LR E + L ++ + +++ + +++ Q S
Sbjct: 1521 LASRVKAEAE-AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579
Query: 517 HELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLS 576
ELQ K R +F EK A LE L + V +L + ++ +
Sbjct: 1580 AELQSK-RASFAEKTAQLE---------RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1629
Query: 577 QRDTMLKELEGKINS---LTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQ 633
+ + L+ + K N L + ++ + + E + ++ ERE R GK EQ
Sbjct: 1630 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR---RRGKAEEQ 1686
Query: 634 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV-------QMKVLSEDKEVLSAE 686
++ EQ++ + E T +++ +Q+L +L Q ++L E+ L E
Sbjct: 1687 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1746
Query: 687 VKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLE 746
+ ++ +L +E ++ ++EV L+ K + T EK Q + E +L E
Sbjct: 1747 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS-EKSKQRLEAEAGRFRELAE 1805
Query: 747 NE-QVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRD 805
+++ L + + L E + E+ + L A+GE+ E + L
Sbjct: 1806 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---- 1861
Query: 806 EKVLELEKEIKCLQEESVVQCEELKSLLR----DYEQEKVLLRKELEEIQSEKEALQSDL 861
EK E E+ ++ L E+ Q L+ D E+ LRK + ++ L D
Sbjct: 1862 EKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1920
Query: 862 LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIH--------NEKEKCFIKEHENL---- 909
L ++ ++E + L ++ K+E+ N ++ KE L
Sbjct: 1921 LR-----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1975
Query: 910 -KPLLEQKELRDRRAELILLKDSLAKSPSVKNDP--LSSVKELEEKIENLEK-ECKEKEE 965
+ L ++E R R AE + K A+ + + L V+ L+ K+E + + ++E
Sbjct: 1976 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2035
Query: 966 KINKIKLVAVKAKKELDSSRK--------ETQTVKEELESLRSEKDQLSASMRDLIQGAE 1017
+++L A+K L + K + Q +++ L+ +S DQL + AE
Sbjct: 2036 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2095
Query: 1018 SYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIET 1077
+ ++ E+++ Q + E A + E+ + + E + + E AR
Sbjct: 2096 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2155
Query: 1078 LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQ 1137
+ A R K D E+E K EQ +++ A EL L++QL++ Q
Sbjct: 2156 AEQAAL----------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2205
Query: 1138 LQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQ 1197
+EL+ +K +A + ++ + ++ ++L+ +IE E I + K
Sbjct: 2206 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE-AENRALILRDKD 2264
Query: 1198 ET---LQEEITSLQSSVQQYE------EKNTKIKQLL---VKTKKELADSKQAETDHLIL 1245
T LQEE ++ ++ ++ +++QL + ++ LA+ E +
Sbjct: 2265 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2324
Query: 1246 QAS-LKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQE 1304
+A+ LK E E QQQ E+ + Q + +K ++ + L + QRTL A +QR
Sbjct: 2325 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR------ 2378
Query: 1305 ECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL-KI 1363
Q +++E E K+RV + +++ ++AE E A++ R+ E + ++L +
Sbjct: 2379 --------QLEMSAEAERLKLRV-----AEMSRAQARAE-EDAQRFRKQAEEIGEKLHRT 2424
Query: 1364 KLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS 1423
+L + + E+Q QS+HD + L+E +++ +EKL +++ + +KS
Sbjct: 2425 ELATQEKVTLVQTLEIQRQQSDHDA------ERLREAIAELEREKEKL-QQEAKLLQLKS 2477
Query: 1424 EHTQTV--SQLTSQNEVLRNSFRDQ-------VRHLQEEHRKTVETLQQQLSKMEAQLFQ 1474
E QTV QL + + L+ SF + R +++E K + Q +++K + QL +
Sbjct: 2478 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ-QLRE 2536
Query: 1475 LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQ 1534
+ + Q+ + ++ E R + +EE + +E + + Q
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2596
Query: 1535 SLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAI------ 1588
L + L E + L H+E V + D L+G E E ++
Sbjct: 2597 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2656
Query: 1589 -----LMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVL-----LQFIFLKPGSERERL 1638
L E L E++RL + A E +++ L + + LK +E+ +
Sbjct: 2657 VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2716
Query: 1639 LPVINTMLQLSP 1650
+ L LSP
Sbjct: 2717 YAALQRQL-LSP 2727
Score = 145 bits (365), Expect = 4e-34
Identities = 355/1856 (19%), Positives = 712/1856 (38%), Gaps = 335/1856 (18%)
Query: 7 DGVASPATPGTGKSKLETLPKE--DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVT 64
+G SPAT G + L L + L+ +K ++ ++ S KE+ L K
Sbjct: 583 EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE 642
Query: 65 EGTGDI------IKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMG---- 114
E D + A E AL+ E L LK++ IK Q D + +
Sbjct: 643 EVGFDWSDRNTNMTAKKESYSALMRE--------LELKEKKIKELQNAGDRLLREDHPAR 694
Query: 115 ------------------------DAHKELEQSHINYVKEIENLKNELM----AVRSKYS 146
+AH + ++ + ++ + +L A+R KYS
Sbjct: 695 PTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 754
Query: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
D++ +LE+ + + EQL + K + + +++P + + L
Sbjct: 755 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLL 814
Query: 207 ATTDEKKETVT-----QLQNIIEANSQHYQKNINSLQEELLQ----LKAIHQEEVKELMC 257
A D K+ VT + Q + A H++ +S E + L +E +E +
Sbjct: 815 AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 874
Query: 258 QIEASAKEHEAEINKLNELKENL--VKQCEASEKNIQKKYECELENLRKATSNANQDNQI 315
++EA +H+A + ++L ++ + ++ +++Q L R Q +
Sbjct: 875 RLEA---QHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR-TLKPEEQRQAL 930
Query: 316 CSILLQENTFV-----------------EQVVNEKVKHLEDTLKELESQH---------- 348
S+ L F+ E+ H + L+ LE
Sbjct: 931 HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 990
Query: 349 SILKD--------EVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKIN------------ 388
S LKD E ++ L+L L+ + + E++ + ++
Sbjct: 991 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1050
Query: 389 -ELLLAKEEQGCVIEKLKSE-------------LAGLNKQFCYTVEQHNREVQSLKE--- 431
E +LA E L+SE L+ + + T+ R Q +E
Sbjct: 1051 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1110
Query: 432 QHQKEISE-------LNETFLSDSEKEKLTLMFEIQ------------GLKEQCENLQQE 472
H++++ E L E + + +KL E Q G +E E LQQ
Sbjct: 1111 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1170
Query: 473 KQEAILNYESLREIM--------------EILQTELGESAGKISQEFES----------- 507
E + E RE + ++ Q EL + ++ ES
Sbjct: 1171 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1230
Query: 508 ---MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNL 564
+Q QA + + Q +R ++ ALLE + R EK+ Q + N IK+
Sbjct: 1231 RRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1286
Query: 565 QEKNGVYLLSLS-------------------QRDTMLKELEGKINSLTEEKDDFINKLKN 605
+ + Y L Q L+ ++ +LT + FI++
Sbjct: 1287 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1346
Query: 606 SHEEMDNF--HKKCEREERL-----ILELGKKV--------EQTIQYNSELEQKVNELTG 650
EE + ++ E ERL LE +++ Q + EL+Q++ E
Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406
Query: 651 GLEETLKEKDQNDQKLEKLMVQMKVLSE-DKEVLSAEVKSLYEENNKLSSEKKQLSRDLE 709
EE + Q + +++ + Q++ SE + + + + ++ ++ E + + LE
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466
Query: 710 VFLSQK-----EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLK 764
Q+ E L+ + E + + EE + L + +++E +K + +L +K
Sbjct: 1467 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1526
Query: 765 EMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVV 824
+E ++ LQA+ E + E + L E+ +++ ++ Q +
Sbjct: 1527 ------AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1580
Query: 825 QCEELKSLLRDYEQEKVLLRKELEE-------IQSEKEALQSDLLEMKNANEKTRLENQ- 876
EL+S + ++ L + L+E ++ E E E + A E+ E +
Sbjct: 1581 ---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637
Query: 877 ---------NLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELIL 927
L +Q EEV+Q S ++ EK+K + + E++ +R R L
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----L 1693
Query: 928 LKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
+ L K + E+++ L E ++ E++ ++ + ++E ++ ++
Sbjct: 1694 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1753
Query: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
Q ++ EL +R+E + L AS + + S EK ++L+ E R
Sbjct: 1754 RQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEAEAGRFRELAEEA 1807
Query: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIETL--QSNAKLLEVQILEVQRAKAMVDKELEA 1105
L + Q + D A E + + A + E L+ + A+ +KE E
Sbjct: 1808 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1867
Query: 1106 EKLQK------------EQKIKEHATTVNE-LEELQ----VQLQKEKKQLQKTMQELELV 1148
E+L++ E++ +H + E L +L+ +L+++K ++ T+++ V
Sbjct: 1868 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1927
Query: 1149 KKD-AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ-EIKIQKQKQETLQEEITS 1206
+++ A L EL + +N + + EQ E++ +Q+Q +EE
Sbjct: 1928 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE--- 1984
Query: 1207 LQSSVQQYEEKNTKIKQLLVKTKKELADSKQA--ETDHLILQASLKGELEASQQQVEVYK 1264
++ E ++++ L ++ K A E + L + L +Q +
Sbjct: 1985 -----RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2039
Query: 1265 IQLAEITSEK-----HKIHEHLKTSAEQH-QRTLSAYQQRVTALQEECRAAK-----AEQ 1313
+QLA+ ++K K H EQ Q+TL Q + L+ E AA+ AE+
Sbjct: 2040 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2099
Query: 1314 ATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ 1373
A V +E E+ + R V + ++ K ++ + + Q + E L + + Q++ Q
Sbjct: 2100 ARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE---QEAARRAQ 2155
Query: 1374 INVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLT 1433
+ L+ Q+ D +E+H K ++T+ ++A++ ++L +++ + + +++H + +
Sbjct: 2156 AEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEETDHQKNLLDEE 2212
Query: 1434 SQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKN 1493
Q + + R EE +V ++LSK++A++ E R+ +
Sbjct: 2213 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-----EAENRALI-------- 2259
Query: 1494 LRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWH 1553
LR++ NT L +EE E M+ E + S Q +L E L
Sbjct: 2260 LRDKDNTQRFL-------QEEAEKMKQV-AEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2311
Query: 1554 AEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQER 1609
AE +E +Q + T+ +A +L +Q +L + + RRL+ ++E+
Sbjct: 2312 AEKMLKEKMQAVQEATR-----------LKAEAELLQQQKELAQEQARRLQEDKEQ 2356
Score = 133 bits (335), Expect = 1e-30
Identities = 333/1795 (18%), Positives = 703/1795 (39%), Gaps = 298/1795 (16%)
Query: 109 SVTKMGDAHKELEQSHINYVKEIENLKNE----LMAVRSKYSEDKANLQKQLEEAMNTQL 164
SV +H+ L QS + +IE +++ A R Y + L Q + +N+
Sbjct: 554 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSS- 612
Query: 165 ELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIE 224
+L+ + V +E+ + EE++ + + KKE+ + L +E
Sbjct: 613 --KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 670
Query: 225 ANSQHYQKNINSLQEELLQ-----------LKAIHQEE---VKELMCQIEASAKEHEAEI 270
+ K + + + LL+ +A Q + + +L C IEA KE+ A
Sbjct: 671 LKEKKI-KELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 729
Query: 271 NKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVV 330
++++E Q + ++ +++KY C+ R AT +D LLQ+ ++ +
Sbjct: 730 QFFSDVRE-AEGQLQKLQEALRRKYSCD----RSATVTRLED------LLQDAQDEKEQL 778
Query: 331 NEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINEL 390
NE HL K ++ + + +L L + + E + D + +
Sbjct: 779 NEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGD---ECQLV 835
Query: 391 LLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQS----LKEQHQKEISELNETFLS 446
A+ V+ SE A C+ V N+E Q L+ QHQ ++ ++ +
Sbjct: 836 GPAQPSHWKVLSSSGSEAA--VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 893
Query: 447 -DSEKEKLTLMFEIQGLKE---------QCENLQQEKQEAILNYES-LREIME------- 488
S +L ++Q ++ + E +Q L+Y++ LR+ +
Sbjct: 894 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 953
Query: 489 ---ILQTELGESAGKISQEFESMK---------QQQASDVHELQQKLRTAFT-------- 528
+ + E G + Q +S++ Q+ S++ +++ +L T
Sbjct: 954 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1013
Query: 529 --EKDALLETVNRL--------------------QGENEKLLSQQELVP-------ELEN 559
+K+ E R+ E EK+L+ E P ELE
Sbjct: 1014 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1073
Query: 560 TIKNLQE---KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDF----------------- 599
T+ L++ + +YL L +++ +G L ++
Sbjct: 1074 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1133
Query: 600 --INKLKNSHEEMDNFHKKCEREERLILELGKKVEQTI-QYNSELE---QKVNELTGGLE 653
+ KL+ E E R E+G++++Q + + E+E ++V +L +
Sbjct: 1134 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1193
Query: 654 ETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLS 713
L + D ++LE+L Q++ E + L A ++ ++ + S+ + L
Sbjct: 1194 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1253
Query: 714 QKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGF---LKEMGSEV 770
Q++ L E I + +K++ +++ ++Q + K QL K+ +
Sbjct: 1254 QEQ--ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1311
Query: 771 SEDSEEKDVVNV--------------LQAVGESLAKINEEKCNLAFQRDEK--------- 807
+S ++ V++ ++ + E+L ++ EE+ QR E+
Sbjct: 1312 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1371
Query: 808 VLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE-EIQSEKEALQSDLLEMKN 866
LE ++++ ++ Q E L+ QE+V+ R+E + Q +K ++Q +L +++
Sbjct: 1372 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1431
Query: 867 ANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRR---- 922
++E ++ +K+ E+ ++ E ++ + Q E +R+
Sbjct: 1432 SSE----------------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1475
Query: 923 -AELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKL-VAVKAKKE 980
EL L+ ++ + K ++ +E+ E L ++ +++ ++ + ++ +A + K E
Sbjct: 1476 EGELQALRARAEEAEAQK-------RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1528
Query: 981 LDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERA 1040
+++R E Q + LE LR + ++ +R + LE ++S + +++ +RA
Sbjct: 1529 AEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1587
Query: 1041 NNFEHRIEDLTRQLRNSTL-----------------QCETINSDNEDLLARIETLQSNAK 1083
+F + L R L+ + + E + E L R + + A
Sbjct: 1588 -SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1646
Query: 1084 LLEVQILEVQRAKAMVDKELEAEKLQKEQ------KIKEHATTVNELEELQVQLQK---E 1134
L +Q EV + K++ E E +K + E+ K +E A EL E +++ Q+ E
Sbjct: 1647 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1706
Query: 1135 KKQLQKTMQELELVKKDA------QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ 1188
Q+ E EL++ A QQ L+ E+A +R QK ++ +
Sbjct: 1707 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1766
Query: 1189 EIKIQKQKQETLQEEITSL-QSSVQQYEEKNTKIKQLL------------VKTKKELAD- 1234
E+++ + +EE S + S Q+ E + + ++L K +++LA+
Sbjct: 1767 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1826
Query: 1235 --SKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTL 1292
++Q +L L EA++ + E +I L E +E ++ + A Q +R
Sbjct: 1827 DAARQRAEAERVLAEKLAAIGEATRLKTEA-EIALKEKEAENERLRRLAEDEAFQRRRLE 1885
Query: 1293 SAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMS----QAETEGAK 1348
Q ++E R A+ +A+ SE E K V + L+Q++ +A E A
Sbjct: 1886 EQAAQHKADIEE--RLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1942
Query: 1349 QEREHLEMLIDQLKIKLQD---SQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA 1405
+ LE+ + +++ +D S+ ++ + + L +E + + +Q++++ E
Sbjct: 1943 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2002
Query: 1406 E-LREKLCSIQS-ENMMMKSEHTQTVSQLTSQNEVLRNSFRDQV--RHLQEEHR------ 1455
E R++ +++ E + K E + + + Q + + + LQ E +
Sbjct: 2003 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2062
Query: 1456 -KTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ-------------QSLKNLRERRNTD 1501
+ + LQQ L + ++ L QL+ E + + QS + + E
Sbjct: 2063 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2122
Query: 1502 LPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEEL 1561
+ + E E+ A+ Q+ + L + H +F ++ L
Sbjct: 2123 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182
Query: 1562 VQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERN--------------- 1606
QK + + L L ET+ +L E+++ LK+E R
Sbjct: 2183 RQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2241
Query: 1607 QEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQ 1661
+E K A +E L+ L+ +R L ++ EE +L+ AQ
Sbjct: 2242 EELSKLKARIEAENRALI----LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2292
Score = 43.1 bits (100), Expect = 0.002
Identities = 204/1030 (19%), Positives = 381/1030 (36%), Gaps = 177/1030 (17%)
Query: 721 KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV 780
K H+ LE++ QL E + E +Q++ K Q+ L E ++ + DV
Sbjct: 376 KLHVAILEREKQLRSEFE-------RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR 428
Query: 781 NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840
L A G+ + E + +L + D + L +++ L++ Q E++ + +
Sbjct: 429 --LLAAGKVPQRAGEVERDLD-KADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERL 485
Query: 841 VLLRKELE---EIQSEKEALQSDLLEMKNANEKTRLEN------QNLLIQVEEVSQTCSK 891
V +R E + A Q + +++ + LE+ Q+LL VEE
Sbjct: 486 VAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG 545
Query: 892 SE--IHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKEL 949
+E + + + H L +E+ + RA D SP+ + + L
Sbjct: 546 AEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR----SDEGQLSPATRGAYRDCLGRL 601
Query: 950 EEKIENLEKECKEKEEKINKIKLVAVKAKKELD-SSRKETQTV----KEELESLRSEKDQ 1004
+ + L K + + + A KEL + KE + V + ++ ++K+
Sbjct: 602 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 661
Query: 1005 LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1064
SA MR+L E + + E + ++L E A + + + LQ
Sbjct: 662 YSALMREL----ELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQ---- 713
Query: 1065 NSDNEDLLARIET-LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123
L IE L+ NA + +V+ A+ + K EA L+++ + + TV
Sbjct: 714 ------LCCCIEAHLKENAAYFQF-FSDVREAEGQLQKLQEA--LRRKYSC-DRSATVTR 763
Query: 1124 LEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN--------------MEIADYERLM 1169
LE+L Q EK+QL + L + K A+ + + + DY+++
Sbjct: 764 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE 823
Query: 1170 KELNQ---------------KLTNKNNKIEDLEQEIKIQKQKQETLQEEITSL----QSS 1210
+++ K+ + + + + + QE +T L Q+
Sbjct: 824 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 883
Query: 1211 VQQYEEKNTKIKQLL----------------VKTKKELADSKQAETDH---LILQASLKG 1251
V + + + +K LL + T + L +Q + H L QA L+
Sbjct: 884 VTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRD 943
Query: 1252 ELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQ------EE 1305
+A E + E S H ++ L S EQ + S Q+ ++ L+ E
Sbjct: 944 SQDAGGFGPEDRLMAEREYGSCSHH-YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEA 1002
Query: 1306 CRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKL 1365
C + + + E + + +QQK +QAE EG + L +++
Sbjct: 1003 CETRTVHRLRLPLDKEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALP 1058
Query: 1366 QDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEH 1425
+ S TL+SE + L + L++ S A EKL +I
Sbjct: 1059 EPS--------PAAPTLRSELELTLGK----LEQVRSLSAIYLEKLKTI----------- 1095
Query: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485
+ + EVLR EE K + + L ++EA
Sbjct: 1096 SLVIRGTQGAEEVLR---------AHEEQLKEAQAVPATLPELEA--------------- 1131
Query: 1486 SSQQSLKNLRERRNTDLP----LLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541
++ SLK LR + P L D +E GE ++ E + + + QLL
Sbjct: 1132 -TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1190
Query: 1542 SPETKL-EPPLWHAEFTKEELVQKLSSTTKSADHLNGLL----RETEATNAILMEQIKLL 1596
+ L + + E E+L ++L +SAD L L R E A+ + + +
Sbjct: 1191 RWQAVLAQTDVRQREL--EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1248
Query: 1597 KSEIRRLER-NQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSP-EEKG 1654
+ ++R+ + +E E+ +E + Q+I + ++ L ++ QL P
Sbjct: 1249 REQLRQEQALLEEIERHGEKVEECQRFAKQYI----NAIKDYELQLVTYKAQLEPVASPA 1304
Query: 1655 KLAAVAQGEE 1664
K V G E
Sbjct: 1305 KKPKVQSGSE 1314
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 216 bits (551), Expect = 1e-55
Identities = 366/1752 (20%), Positives = 716/1752 (40%), Gaps = 197/1752 (11%)
Query: 11 SPATPGTGKSKLE-TLPKEDLIKFAK-------KQMMLIQKAKSRCTEL----EKEIEEL 58
SPA P T +S+LE TL K + ++ K + L+ + E+ E++++E
Sbjct: 1057 SPAAP-TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1115
Query: 59 RSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKM-GDAH 117
++ P T + KA ++L A +AE +Q ++ ++ QEV + + + G+
Sbjct: 1116 QAVPATLPELEATKASLKKLRA----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1171
Query: 118 KELEQSHINYV-----------------KEIENLKNELMAVRSKYSEDKANLQ---KQLE 157
E+E+ +E+E L +L R A LQ ++ E
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1231
Query: 158 EAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVT 217
+ L S+ ++ Q E + L EEIE+ EE + ++ ++A D + + VT
Sbjct: 1232 QIQAMPLADSQAVREQLRQE---QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288
Query: 218 QLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELK 277
+ S + + S E ++Q + EL K + ++ E +
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-E 1347
Query: 278 ENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHL 337
E L +Q A E+ + E LE R+ A Q + +E ++Q + E+V
Sbjct: 1348 ERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 338 EDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQ 397
E+ + + Q +++E + L+ E + Q K E +I E + Q
Sbjct: 1405 EEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQ-AKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 398 GCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF 457
+E + + G + + E ++ K Q Q+E L +S++++ +
Sbjct: 1461 ---LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516
Query: 458 EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFE-SMKQQQASDV 516
+K + E +EKQ A+ E LR E + L ++ + +++ + +++ Q S
Sbjct: 1517 LASRVKAEAE-AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 517 HELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLS 576
ELQ K R +F EK A LE L + V +L + ++ +
Sbjct: 1576 AELQSK-RASFAEKTAQLE---------RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 577 QRDTMLKELEGKINS---LTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQ 633
+ + L+ + K N L + ++ + + E + ++ ERE R GK EQ
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR---RRGKAEEQ 1682
Query: 634 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV-------QMKVLSEDKEVLSAE 686
++ EQ++ + E T +++ +Q+L +L Q ++L E+ L E
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 687 VKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLE 746
+ ++ +L +E ++ ++EV L+ K + T EK Q + E +L E
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS-EKSKQRLEAEAGRFRELAE 1801
Query: 747 NE-QVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRD 805
+++ L + + L E + E+ + L A+GE+ E + L
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---- 1857
Query: 806 EKVLELEKEIKCLQEESVVQCEELKSLLR----DYEQEKVLLRKELEEIQSEKEALQSDL 861
EK E E+ ++ L E+ Q L+ D E+ LRK + ++ L D
Sbjct: 1858 EKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1916
Query: 862 LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIH--------NEKEKCFIKEHENL---- 909
L ++ ++E + L ++ K+E+ N ++ KE L
Sbjct: 1917 LR-----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1971
Query: 910 -KPLLEQKELRDRRAELILLKDSLAKSPSVKNDP--LSSVKELEEKIENLEK-ECKEKEE 965
+ L ++E R R AE + K A+ + + L V+ L+ K+E + + ++E
Sbjct: 1972 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2031
Query: 966 KINKIKLVAVKAKKELDSSRK--------ETQTVKEELESLRSEKDQLSASMRDLIQGAE 1017
+++L A+K L + K + Q +++ L+ +S DQL + AE
Sbjct: 2032 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2091
Query: 1018 SYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIET 1077
+ ++ E+++ Q + E A + E+ + + E + + E AR
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2151
Query: 1078 LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQ 1137
+ A R K D E+E K EQ +++ A EL L++QL++ Q
Sbjct: 2152 AEQAAL----------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2201
Query: 1138 LQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQ 1197
+EL+ +K +A + ++ + ++ ++L+ +IE E I + K
Sbjct: 2202 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE-AENRALILRDKD 2260
Query: 1198 ET---LQEEITSLQSSVQQYE------EKNTKIKQLL---VKTKKELADSKQAETDHLIL 1245
T LQEE ++ ++ ++ +++QL + ++ LA+ E +
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320
Query: 1246 QAS-LKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQE 1304
+A+ LK E E QQQ E+ + Q + +K ++ + L + QRTL A +QR
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR------ 2374
Query: 1305 ECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL-KI 1363
Q +++E E K+RV + +++ ++AE E A++ R+ E + ++L +
Sbjct: 2375 --------QLEMSAEAERLKLRV-----AEMSRAQARAE-EDAQRFRKQAEEIGEKLHRT 2420
Query: 1364 KLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS 1423
+L + + E+Q QS+HD + L+E +++ +EKL +++ + +KS
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDA------ERLREAIAELEREKEKL-QQEAKLLQLKS 2473
Query: 1424 EHTQTV--SQLTSQNEVLRNSFRDQ-------VRHLQEEHRKTVETLQQQLSKMEAQLFQ 1474
E QTV QL + + L+ SF + R +++E K + Q +++K + QL +
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ-QLRE 2532
Query: 1475 LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQ 1534
+ + Q+ + ++ E R + +EE + +E + + Q
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2592
Query: 1535 SLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAI------ 1588
L + L E + L H+E V + D L+G E E ++
Sbjct: 2593 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2652
Query: 1589 -----LMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVL-----LQFIFLKPGSERERL 1638
L E L E++RL + A E +++ L + + LK +E+ +
Sbjct: 2653 VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2712
Query: 1639 LPVINTMLQLSP 1650
+ L LSP
Sbjct: 2713 YAALQRQL-LSP 2723
Score = 145 bits (365), Expect = 4e-34
Identities = 355/1856 (19%), Positives = 712/1856 (38%), Gaps = 335/1856 (18%)
Query: 7 DGVASPATPGTGKSKLETLPKE--DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVT 64
+G SPAT G + L L + L+ +K ++ ++ S KE+ L K
Sbjct: 579 EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE 638
Query: 65 EGTGDI------IKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMG---- 114
E D + A E AL+ E L LK++ IK Q D + +
Sbjct: 639 EVGFDWSDRNTNMTAKKESYSALMRE--------LELKEKKIKELQNAGDRLLREDHPAR 690
Query: 115 ------------------------DAHKELEQSHINYVKEIENLKNELM----AVRSKYS 146
+AH + ++ + ++ + +L A+R KYS
Sbjct: 691 PTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 750
Query: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
D++ +LE+ + + EQL + K + + +++P + + L
Sbjct: 751 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLL 810
Query: 207 ATTDEKKETVT-----QLQNIIEANSQHYQKNINSLQEELLQ----LKAIHQEEVKELMC 257
A D K+ VT + Q + A H++ +S E + L +E +E +
Sbjct: 811 AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 870
Query: 258 QIEASAKEHEAEINKLNELKENL--VKQCEASEKNIQKKYECELENLRKATSNANQDNQI 315
++EA +H+A + ++L ++ + ++ +++Q L R Q +
Sbjct: 871 RLEA---QHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR-TLKPEEQRQAL 926
Query: 316 CSILLQENTFV-----------------EQVVNEKVKHLEDTLKELESQH---------- 348
S+ L F+ E+ H + L+ LE
Sbjct: 927 HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 986
Query: 349 SILKD--------EVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKIN------------ 388
S LKD E ++ L+L L+ + + E++ + ++
Sbjct: 987 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1046
Query: 389 -ELLLAKEEQGCVIEKLKSE-------------LAGLNKQFCYTVEQHNREVQSLKE--- 431
E +LA E L+SE L+ + + T+ R Q +E
Sbjct: 1047 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1106
Query: 432 QHQKEISE-------LNETFLSDSEKEKLTLMFEIQ------------GLKEQCENLQQE 472
H++++ E L E + + +KL E Q G +E E LQQ
Sbjct: 1107 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1166
Query: 473 KQEAILNYESLREIM--------------EILQTELGESAGKISQEFES----------- 507
E + E RE + ++ Q EL + ++ ES
Sbjct: 1167 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1226
Query: 508 ---MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNL 564
+Q QA + + Q +R ++ ALLE + R EK+ Q + N IK+
Sbjct: 1227 RRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1282
Query: 565 QEKNGVYLLSLS-------------------QRDTMLKELEGKINSLTEEKDDFINKLKN 605
+ + Y L Q L+ ++ +LT + FI++
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342
Query: 606 SHEEMDNF--HKKCEREERL-----ILELGKKV--------EQTIQYNSELEQKVNELTG 650
EE + ++ E ERL LE +++ Q + EL+Q++ E
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 651 GLEETLKEKDQNDQKLEKLMVQMKVLSE-DKEVLSAEVKSLYEENNKLSSEKKQLSRDLE 709
EE + Q + +++ + Q++ SE + + + + ++ ++ E + + LE
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 710 VFLSQK-----EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLK 764
Q+ E L+ + E + + EE + L + +++E +K + +L +K
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522
Query: 765 EMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVV 824
+E ++ LQA+ E + E + L E+ +++ ++ Q +
Sbjct: 1523 ------AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576
Query: 825 QCEELKSLLRDYEQEKVLLRKELEE-------IQSEKEALQSDLLEMKNANEKTRLENQ- 876
EL+S + ++ L + L+E ++ E E E + A E+ E +
Sbjct: 1577 ---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 877 ---------NLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELIL 927
L +Q EEV+Q S ++ EK+K + + E++ +R R L
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----L 1689
Query: 928 LKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
+ L K + E+++ L E ++ E++ ++ + ++E ++ ++
Sbjct: 1690 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749
Query: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
Q ++ EL +R+E + L AS + + S EK ++L+ E R
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEAEAGRFRELAEEA 1803
Query: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIETL--QSNAKLLEVQILEVQRAKAMVDKELEA 1105
L + Q + D A E + + A + E L+ + A+ +KE E
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 1106 EKLQK------------EQKIKEHATTVNE-LEELQ----VQLQKEKKQLQKTMQELELV 1148
E+L++ E++ +H + E L +L+ +L+++K ++ T+++ V
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 1149 KKD-AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ-EIKIQKQKQETLQEEITS 1206
+++ A L EL + +N + + EQ E++ +Q+Q +EE
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE--- 1980
Query: 1207 LQSSVQQYEEKNTKIKQLLVKTKKELADSKQA--ETDHLILQASLKGELEASQQQVEVYK 1264
++ E ++++ L ++ K A E + L + L +Q +
Sbjct: 1981 -----RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035
Query: 1265 IQLAEITSEK-----HKIHEHLKTSAEQH-QRTLSAYQQRVTALQEECRAAK-----AEQ 1313
+QLA+ ++K K H EQ Q+TL Q + L+ E AA+ AE+
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 1314 ATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ 1373
A V +E E+ + R V + ++ K ++ + + Q + E L + + Q++ Q
Sbjct: 2096 ARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE---QEAARRAQ 2151
Query: 1374 INVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLT 1433
+ L+ Q+ D +E+H K ++T+ ++A++ ++L +++ + + +++H + +
Sbjct: 2152 AEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEETDHQKNLLDEE 2208
Query: 1434 SQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKN 1493
Q + + R EE +V ++LSK++A++ E R+ +
Sbjct: 2209 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-----EAENRALI-------- 2255
Query: 1494 LRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWH 1553
LR++ NT L +EE E M+ E + S Q +L E L
Sbjct: 2256 LRDKDNTQRFL-------QEEAEKMKQV-AEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307
Query: 1554 AEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQER 1609
AE +E +Q + T+ +A +L +Q +L + + RRL+ ++E+
Sbjct: 2308 AEKMLKEKMQAVQEATR-----------LKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Score = 133 bits (335), Expect = 1e-30
Identities = 333/1795 (18%), Positives = 703/1795 (39%), Gaps = 298/1795 (16%)
Query: 109 SVTKMGDAHKELEQSHINYVKEIENLKNE----LMAVRSKYSEDKANLQKQLEEAMNTQL 164
SV +H+ L QS + +IE +++ A R Y + L Q + +N+
Sbjct: 550 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSS- 608
Query: 165 ELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIE 224
+L+ + V +E+ + EE++ + + KKE+ + L +E
Sbjct: 609 --KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 666
Query: 225 ANSQHYQKNINSLQEELLQ-----------LKAIHQEE---VKELMCQIEASAKEHEAEI 270
+ K + + + LL+ +A Q + + +L C IEA KE+ A
Sbjct: 667 LKEKKI-KELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 725
Query: 271 NKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVV 330
++++E Q + ++ +++KY C+ R AT +D LLQ+ ++ +
Sbjct: 726 QFFSDVRE-AEGQLQKLQEALRRKYSCD----RSATVTRLED------LLQDAQDEKEQL 774
Query: 331 NEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINEL 390
NE HL K ++ + + +L L + + E + D + +
Sbjct: 775 NEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGD---ECQLV 831
Query: 391 LLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQS----LKEQHQKEISELNETFLS 446
A+ V+ SE A C+ V N+E Q L+ QHQ ++ ++ +
Sbjct: 832 GPAQPSHWKVLSSSGSEAA--VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 889
Query: 447 -DSEKEKLTLMFEIQGLKE---------QCENLQQEKQEAILNYES-LREIME------- 488
S +L ++Q ++ + E +Q L+Y++ LR+ +
Sbjct: 890 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 949
Query: 489 ---ILQTELGESAGKISQEFESMK---------QQQASDVHELQQKLRTAFT-------- 528
+ + E G + Q +S++ Q+ S++ +++ +L T
Sbjct: 950 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1009
Query: 529 --EKDALLETVNRL--------------------QGENEKLLSQQELVP-------ELEN 559
+K+ E R+ E EK+L+ E P ELE
Sbjct: 1010 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1069
Query: 560 TIKNLQE---KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDF----------------- 599
T+ L++ + +YL L +++ +G L ++
Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1129
Query: 600 --INKLKNSHEEMDNFHKKCEREERLILELGKKVEQTI-QYNSELE---QKVNELTGGLE 653
+ KL+ E E R E+G++++Q + + E+E ++V +L +
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189
Query: 654 ETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLS 713
L + D ++LE+L Q++ E + L A ++ ++ + S+ + L
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1249
Query: 714 QKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGF---LKEMGSEV 770
Q++ L E I + +K++ +++ ++Q + K QL K+ +
Sbjct: 1250 QEQ--ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1307
Query: 771 SEDSEEKDVVNV--------------LQAVGESLAKINEEKCNLAFQRDEK--------- 807
+S ++ V++ ++ + E+L ++ EE+ QR E+
Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1367
Query: 808 VLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE-EIQSEKEALQSDLLEMKN 866
LE ++++ ++ Q E L+ QE+V+ R+E + Q +K ++Q +L +++
Sbjct: 1368 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1427
Query: 867 ANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRR---- 922
++E ++ +K+ E+ ++ E ++ + Q E +R+
Sbjct: 1428 SSE----------------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1471
Query: 923 -AELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKL-VAVKAKKE 980
EL L+ ++ + K ++ +E+ E L ++ +++ ++ + ++ +A + K E
Sbjct: 1472 EGELQALRARAEEAEAQK-------RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524
Query: 981 LDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERA 1040
+++R E Q + LE LR + ++ +R + LE ++S + +++ +RA
Sbjct: 1525 AEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583
Query: 1041 NNFEHRIEDLTRQLRNSTL-----------------QCETINSDNEDLLARIETLQSNAK 1083
+F + L R L+ + + E + E L R + + A
Sbjct: 1584 -SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
Query: 1084 LLEVQILEVQRAKAMVDKELEAEKLQKEQ------KIKEHATTVNELEELQVQLQK---E 1134
L +Q EV + K++ E E +K + E+ K +E A EL E +++ Q+ E
Sbjct: 1643 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1702
Query: 1135 KKQLQKTMQELELVKKDA------QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ 1188
Q+ E EL++ A QQ L+ E+A +R QK ++ +
Sbjct: 1703 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1762
Query: 1189 EIKIQKQKQETLQEEITSL-QSSVQQYEEKNTKIKQLL------------VKTKKELAD- 1234
E+++ + +EE S + S Q+ E + + ++L K +++LA+
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 1235 --SKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTL 1292
++Q +L L EA++ + E +I L E +E ++ + A Q +R
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEA-EIALKEKEAENERLRRLAEDEAFQRRRLE 1881
Query: 1293 SAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMS----QAETEGAK 1348
Q ++E R A+ +A+ SE E K V + L+Q++ +A E A
Sbjct: 1882 EQAAQHKADIEE--RLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938
Query: 1349 QEREHLEMLIDQLKIKLQD---SQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA 1405
+ LE+ + +++ +D S+ ++ + + L +E + + +Q++++ E
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998
Query: 1406 E-LREKLCSIQS-ENMMMKSEHTQTVSQLTSQNEVLRNSFRDQV--RHLQEEHR------ 1455
E R++ +++ E + K E + + + Q + + + LQ E +
Sbjct: 1999 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2058
Query: 1456 -KTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ-------------QSLKNLRERRNTD 1501
+ + LQQ L + ++ L QL+ E + + QS + + E
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 1502 LPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEEL 1561
+ + E E+ A+ Q+ + L + H +F ++ L
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 1562 VQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERN--------------- 1606
QK + + L L ET+ +L E+++ LK+E R
Sbjct: 2179 RQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2237
Query: 1607 QEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQ 1661
+E K A +E L+ L+ +R L ++ EE +L+ AQ
Sbjct: 2238 EELSKLKARIEAENRALI----LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2288
Score = 43.1 bits (100), Expect = 0.002
Identities = 204/1030 (19%), Positives = 381/1030 (36%), Gaps = 177/1030 (17%)
Query: 721 KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV 780
K H+ LE++ QL E + E +Q++ K Q+ L E ++ + DV
Sbjct: 372 KLHVAILEREKQLRSEFE-------RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR 424
Query: 781 NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840
L A G+ + E + +L + D + L +++ L++ Q E++ + +
Sbjct: 425 --LLAAGKVPQRAGEVERDLD-KADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERL 481
Query: 841 VLLRKELE---EIQSEKEALQSDLLEMKNANEKTRLEN------QNLLIQVEEVSQTCSK 891
V +R E + A Q + +++ + LE+ Q+LL VEE
Sbjct: 482 VAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG 541
Query: 892 SE--IHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKEL 949
+E + + + H L +E+ + RA D SP+ + + L
Sbjct: 542 AEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR----SDEGQLSPATRGAYRDCLGRL 597
Query: 950 EEKIENLEKECKEKEEKINKIKLVAVKAKKELD-SSRKETQTV----KEELESLRSEKDQ 1004
+ + L K + + + A KEL + KE + V + ++ ++K+
Sbjct: 598 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 657
Query: 1005 LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1064
SA MR+L E + + E + ++L E A + + + LQ
Sbjct: 658 YSALMREL----ELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQ---- 709
Query: 1065 NSDNEDLLARIET-LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123
L IE L+ NA + +V+ A+ + K EA L+++ + + TV
Sbjct: 710 ------LCCCIEAHLKENAAYFQF-FSDVREAEGQLQKLQEA--LRRKYSC-DRSATVTR 759
Query: 1124 LEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN--------------MEIADYERLM 1169
LE+L Q EK+QL + L + K A+ + + + DY+++
Sbjct: 760 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE 819
Query: 1170 KELNQ---------------KLTNKNNKIEDLEQEIKIQKQKQETLQEEITSL----QSS 1210
+++ K+ + + + + + QE +T L Q+
Sbjct: 820 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 879
Query: 1211 VQQYEEKNTKIKQLL----------------VKTKKELADSKQAETDH---LILQASLKG 1251
V + + + +K LL + T + L +Q + H L QA L+
Sbjct: 880 VTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRD 939
Query: 1252 ELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQ------EE 1305
+A E + E S H ++ L S EQ + S Q+ ++ L+ E
Sbjct: 940 SQDAGGFGPEDRLMAEREYGSCSHH-YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEA 998
Query: 1306 CRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKL 1365
C + + + E + + +QQK +QAE EG + L +++
Sbjct: 999 CETRTVHRLRLPLDKEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALP 1054
Query: 1366 QDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEH 1425
+ S TL+SE + L + L++ S A EKL +I
Sbjct: 1055 EPS--------PAAPTLRSELELTLGK----LEQVRSLSAIYLEKLKTI----------- 1091
Query: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485
+ + EVLR EE K + + L ++EA
Sbjct: 1092 SLVIRGTQGAEEVLR---------AHEEQLKEAQAVPATLPELEA--------------- 1127
Query: 1486 SSQQSLKNLRERRNTDLP----LLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541
++ SLK LR + P L D +E GE ++ E + + + QLL
Sbjct: 1128 -TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1186
Query: 1542 SPETKL-EPPLWHAEFTKEELVQKLSSTTKSADHLNGLL----RETEATNAILMEQIKLL 1596
+ L + + E E+L ++L +SAD L L R E A+ + + +
Sbjct: 1187 RWQAVLAQTDVRQREL--EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244
Query: 1597 KSEIRRLER-NQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSP-EEKG 1654
+ ++R+ + +E E+ +E + Q+I + ++ L ++ QL P
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYI----NAIKDYELQLVTYKAQLEPVASPA 1300
Query: 1655 KLAAVAQGEE 1664
K V G E
Sbjct: 1301 KKPKVQSGSE 1310
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 216 bits (551), Expect = 1e-55
Identities = 366/1752 (20%), Positives = 716/1752 (40%), Gaps = 197/1752 (11%)
Query: 11 SPATPGTGKSKLE-TLPKEDLIKFAK-------KQMMLIQKAKSRCTEL----EKEIEEL 58
SPA P T +S+LE TL K + ++ K + L+ + E+ E++++E
Sbjct: 1025 SPAAP-TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1083
Query: 59 RSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKM-GDAH 117
++ P T + KA ++L A +AE +Q ++ ++ QEV + + + G+
Sbjct: 1084 QAVPATLPELEATKASLKKLRA----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1139
Query: 118 KELEQSHINYV-----------------KEIENLKNELMAVRSKYSEDKANLQ---KQLE 157
E+E+ +E+E L +L R A LQ ++ E
Sbjct: 1140 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1199
Query: 158 EAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVT 217
+ L S+ ++ Q E + L EEIE+ EE + ++ ++A D + + VT
Sbjct: 1200 QIQAMPLADSQAVREQLRQE---QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1256
Query: 218 QLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELK 277
+ S + + S E ++Q + EL K + ++ E +
Sbjct: 1257 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-E 1315
Query: 278 ENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHL 337
E L +Q A E+ + E LE R+ A Q + +E ++Q + E+V
Sbjct: 1316 ERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAEREAKELQQRMQEEVVRR 1372
Query: 338 EDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQ 397
E+ + + Q +++E + L+ E + Q K E +I E + Q
Sbjct: 1373 EEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQ-AKARQAEAAERSRLRIEEEIRVVRLQ 1428
Query: 398 GCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF 457
+E + + G + + E ++ K Q Q+E L +S++++ +
Sbjct: 1429 ---LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1484
Query: 458 EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFE-SMKQQQASDV 516
+K + E +EKQ A+ E LR E + L ++ + +++ + +++ Q S
Sbjct: 1485 LASRVKAEAE-AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543
Query: 517 HELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLS 576
ELQ K R +F EK A LE L + V +L + ++ +
Sbjct: 1544 AELQSK-RASFAEKTAQLE---------RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1593
Query: 577 QRDTMLKELEGKINS---LTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQ 633
+ + L+ + K N L + ++ + + E + ++ ERE R GK EQ
Sbjct: 1594 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR---RRGKAEEQ 1650
Query: 634 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV-------QMKVLSEDKEVLSAE 686
++ EQ++ + E T +++ +Q+L +L Q ++L E+ L E
Sbjct: 1651 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1710
Query: 687 VKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLE 746
+ ++ +L +E ++ ++EV L+ K + T EK Q + E +L E
Sbjct: 1711 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS-EKSKQRLEAEAGRFRELAE 1769
Query: 747 NE-QVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRD 805
+++ L + + L E + E+ + L A+GE+ E + L
Sbjct: 1770 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---- 1825
Query: 806 EKVLELEKEIKCLQEESVVQCEELKSLLR----DYEQEKVLLRKELEEIQSEKEALQSDL 861
EK E E+ ++ L E+ Q L+ D E+ LRK + ++ L D
Sbjct: 1826 EKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1884
Query: 862 LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIH--------NEKEKCFIKEHENL---- 909
L ++ ++E + L ++ K+E+ N ++ KE L
Sbjct: 1885 LR-----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1939
Query: 910 -KPLLEQKELRDRRAELILLKDSLAKSPSVKNDP--LSSVKELEEKIENLEK-ECKEKEE 965
+ L ++E R R AE + K A+ + + L V+ L+ K+E + + ++E
Sbjct: 1940 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 1999
Query: 966 KINKIKLVAVKAKKELDSSRK--------ETQTVKEELESLRSEKDQLSASMRDLIQGAE 1017
+++L A+K L + K + Q +++ L+ +S DQL + AE
Sbjct: 2000 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2059
Query: 1018 SYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIET 1077
+ ++ E+++ Q + E A + E+ + + E + + E AR
Sbjct: 2060 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2119
Query: 1078 LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQ 1137
+ A R K D E+E K EQ +++ A EL L++QL++ Q
Sbjct: 2120 AEQAAL----------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2169
Query: 1138 LQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQ 1197
+EL+ +K +A + ++ + ++ ++L+ +IE E I + K
Sbjct: 2170 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE-AENRALILRDKD 2228
Query: 1198 ET---LQEEITSLQSSVQQYE------EKNTKIKQLL---VKTKKELADSKQAETDHLIL 1245
T LQEE ++ ++ ++ +++QL + ++ LA+ E +
Sbjct: 2229 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2288
Query: 1246 QAS-LKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQE 1304
+A+ LK E E QQQ E+ + Q + +K ++ + L + QRTL A +QR
Sbjct: 2289 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR------ 2342
Query: 1305 ECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL-KI 1363
Q +++E E K+RV + +++ ++AE E A++ R+ E + ++L +
Sbjct: 2343 --------QLEMSAEAERLKLRV-----AEMSRAQARAE-EDAQRFRKQAEEIGEKLHRT 2388
Query: 1364 KLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS 1423
+L + + E+Q QS+HD + L+E +++ +EKL +++ + +KS
Sbjct: 2389 ELATQEKVTLVQTLEIQRQQSDHDA------ERLREAIAELEREKEKL-QQEAKLLQLKS 2441
Query: 1424 EHTQTV--SQLTSQNEVLRNSFRDQ-------VRHLQEEHRKTVETLQQQLSKMEAQLFQ 1474
E QTV QL + + L+ SF + R +++E K + Q +++K + QL +
Sbjct: 2442 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ-QLRE 2500
Query: 1475 LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQ 1534
+ + Q+ + ++ E R + +EE + +E + + Q
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2560
Query: 1535 SLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAI------ 1588
L + L E + L H+E V + D L+G E E ++
Sbjct: 2561 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2620
Query: 1589 -----LMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVL-----LQFIFLKPGSERERL 1638
L E L E++RL + A E +++ L + + LK +E+ +
Sbjct: 2621 VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2680
Query: 1639 LPVINTMLQLSP 1650
+ L LSP
Sbjct: 2681 YAALQRQL-LSP 2691
Score = 145 bits (365), Expect = 4e-34
Identities = 355/1856 (19%), Positives = 712/1856 (38%), Gaps = 335/1856 (18%)
Query: 7 DGVASPATPGTGKSKLETLPKE--DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVT 64
+G SPAT G + L L + L+ +K ++ ++ S KE+ L K
Sbjct: 547 EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE 606
Query: 65 EGTGDI------IKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMG---- 114
E D + A E AL+ E L LK++ IK Q D + +
Sbjct: 607 EVGFDWSDRNTNMTAKKESYSALMRE--------LELKEKKIKELQNAGDRLLREDHPAR 658
Query: 115 ------------------------DAHKELEQSHINYVKEIENLKNELM----AVRSKYS 146
+AH + ++ + ++ + +L A+R KYS
Sbjct: 659 PTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 718
Query: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
D++ +LE+ + + EQL + K + + +++P + + L
Sbjct: 719 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLL 778
Query: 207 ATTDEKKETVT-----QLQNIIEANSQHYQKNINSLQEELLQ----LKAIHQEEVKELMC 257
A D K+ VT + Q + A H++ +S E + L +E +E +
Sbjct: 779 AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 838
Query: 258 QIEASAKEHEAEINKLNELKENL--VKQCEASEKNIQKKYECELENLRKATSNANQDNQI 315
++EA +H+A + ++L ++ + ++ +++Q L R Q +
Sbjct: 839 RLEA---QHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR-TLKPEEQRQAL 894
Query: 316 CSILLQENTFV-----------------EQVVNEKVKHLEDTLKELESQH---------- 348
S+ L F+ E+ H + L+ LE
Sbjct: 895 HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 954
Query: 349 SILKD--------EVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKIN------------ 388
S LKD E ++ L+L L+ + + E++ + ++
Sbjct: 955 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1014
Query: 389 -ELLLAKEEQGCVIEKLKSE-------------LAGLNKQFCYTVEQHNREVQSLKE--- 431
E +LA E L+SE L+ + + T+ R Q +E
Sbjct: 1015 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1074
Query: 432 QHQKEISE-------LNETFLSDSEKEKLTLMFEIQ------------GLKEQCENLQQE 472
H++++ E L E + + +KL E Q G +E E LQQ
Sbjct: 1075 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1134
Query: 473 KQEAILNYESLREIM--------------EILQTELGESAGKISQEFES----------- 507
E + E RE + ++ Q EL + ++ ES
Sbjct: 1135 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1194
Query: 508 ---MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNL 564
+Q QA + + Q +R ++ ALLE + R EK+ Q + N IK+
Sbjct: 1195 RRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1250
Query: 565 QEKNGVYLLSLS-------------------QRDTMLKELEGKINSLTEEKDDFINKLKN 605
+ + Y L Q L+ ++ +LT + FI++
Sbjct: 1251 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1310
Query: 606 SHEEMDNF--HKKCEREERL-----ILELGKKV--------EQTIQYNSELEQKVNELTG 650
EE + ++ E ERL LE +++ Q + EL+Q++ E
Sbjct: 1311 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370
Query: 651 GLEETLKEKDQNDQKLEKLMVQMKVLSE-DKEVLSAEVKSLYEENNKLSSEKKQLSRDLE 709
EE + Q + +++ + Q++ SE + + + + ++ ++ E + + LE
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1430
Query: 710 VFLSQK-----EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLK 764
Q+ E L+ + E + + EE + L + +++E +K + +L +K
Sbjct: 1431 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1490
Query: 765 EMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVV 824
+E ++ LQA+ E + E + L E+ +++ ++ Q +
Sbjct: 1491 ------AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1544
Query: 825 QCEELKSLLRDYEQEKVLLRKELEE-------IQSEKEALQSDLLEMKNANEKTRLENQ- 876
EL+S + ++ L + L+E ++ E E E + A E+ E +
Sbjct: 1545 ---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601
Query: 877 ---------NLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELIL 927
L +Q EEV+Q S ++ EK+K + + E++ +R R L
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----L 1657
Query: 928 LKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
+ L K + E+++ L E ++ E++ ++ + ++E ++ ++
Sbjct: 1658 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1717
Query: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
Q ++ EL +R+E + L AS + + S EK ++L+ E R
Sbjct: 1718 RQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEAEAGRFRELAEEA 1771
Query: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIETL--QSNAKLLEVQILEVQRAKAMVDKELEA 1105
L + Q + D A E + + A + E L+ + A+ +KE E
Sbjct: 1772 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1831
Query: 1106 EKLQK------------EQKIKEHATTVNE-LEELQ----VQLQKEKKQLQKTMQELELV 1148
E+L++ E++ +H + E L +L+ +L+++K ++ T+++ V
Sbjct: 1832 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1891
Query: 1149 KKD-AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ-EIKIQKQKQETLQEEITS 1206
+++ A L EL + +N + + EQ E++ +Q+Q +EE
Sbjct: 1892 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE--- 1948
Query: 1207 LQSSVQQYEEKNTKIKQLLVKTKKELADSKQA--ETDHLILQASLKGELEASQQQVEVYK 1264
++ E ++++ L ++ K A E + L + L +Q +
Sbjct: 1949 -----RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2003
Query: 1265 IQLAEITSEK-----HKIHEHLKTSAEQH-QRTLSAYQQRVTALQEECRAAK-----AEQ 1313
+QLA+ ++K K H EQ Q+TL Q + L+ E AA+ AE+
Sbjct: 2004 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2063
Query: 1314 ATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ 1373
A V +E E+ + R V + ++ K ++ + + Q + E L + + Q++ Q
Sbjct: 2064 ARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE---QEAARRAQ 2119
Query: 1374 INVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLT 1433
+ L+ Q+ D +E+H K ++T+ ++A++ ++L +++ + + +++H + +
Sbjct: 2120 AEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEETDHQKNLLDEE 2176
Query: 1434 SQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKN 1493
Q + + R EE +V ++LSK++A++ E R+ +
Sbjct: 2177 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-----EAENRALI-------- 2223
Query: 1494 LRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWH 1553
LR++ NT L +EE E M+ E + S Q +L E L
Sbjct: 2224 LRDKDNTQRFL-------QEEAEKMKQV-AEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2275
Query: 1554 AEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQER 1609
AE +E +Q + T+ +A +L +Q +L + + RRL+ ++E+
Sbjct: 2276 AEKMLKEKMQAVQEATR-----------LKAEAELLQQQKELAQEQARRLQEDKEQ 2320
Score = 133 bits (335), Expect = 1e-30
Identities = 333/1795 (18%), Positives = 703/1795 (39%), Gaps = 298/1795 (16%)
Query: 109 SVTKMGDAHKELEQSHINYVKEIENLKNE----LMAVRSKYSEDKANLQKQLEEAMNTQL 164
SV +H+ L QS + +IE +++ A R Y + L Q + +N+
Sbjct: 518 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSS- 576
Query: 165 ELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIE 224
+L+ + V +E+ + EE++ + + KKE+ + L +E
Sbjct: 577 --KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 634
Query: 225 ANSQHYQKNINSLQEELLQ-----------LKAIHQEE---VKELMCQIEASAKEHEAEI 270
+ K + + + LL+ +A Q + + +L C IEA KE+ A
Sbjct: 635 LKEKKI-KELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 693
Query: 271 NKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVV 330
++++E Q + ++ +++KY C+ R AT +D LLQ+ ++ +
Sbjct: 694 QFFSDVRE-AEGQLQKLQEALRRKYSCD----RSATVTRLED------LLQDAQDEKEQL 742
Query: 331 NEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINEL 390
NE HL K ++ + + +L L + + E + D + +
Sbjct: 743 NEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGD---ECQLV 799
Query: 391 LLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQS----LKEQHQKEISELNETFLS 446
A+ V+ SE A C+ V N+E Q L+ QHQ ++ ++ +
Sbjct: 800 GPAQPSHWKVLSSSGSEAA--VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 857
Query: 447 -DSEKEKLTLMFEIQGLKE---------QCENLQQEKQEAILNYES-LREIME------- 488
S +L ++Q ++ + E +Q L+Y++ LR+ +
Sbjct: 858 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 917
Query: 489 ---ILQTELGESAGKISQEFESMK---------QQQASDVHELQQKLRTAFT-------- 528
+ + E G + Q +S++ Q+ S++ +++ +L T
Sbjct: 918 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 977
Query: 529 --EKDALLETVNRL--------------------QGENEKLLSQQELVP-------ELEN 559
+K+ E R+ E EK+L+ E P ELE
Sbjct: 978 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1037
Query: 560 TIKNLQE---KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDF----------------- 599
T+ L++ + +YL L +++ +G L ++
Sbjct: 1038 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1097
Query: 600 --INKLKNSHEEMDNFHKKCEREERLILELGKKVEQTI-QYNSELE---QKVNELTGGLE 653
+ KL+ E E R E+G++++Q + + E+E ++V +L +
Sbjct: 1098 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1157
Query: 654 ETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLS 713
L + D ++LE+L Q++ E + L A ++ ++ + S+ + L
Sbjct: 1158 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1217
Query: 714 QKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGF---LKEMGSEV 770
Q++ L E I + +K++ +++ ++Q + K QL K+ +
Sbjct: 1218 QEQ--ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1275
Query: 771 SEDSEEKDVVNV--------------LQAVGESLAKINEEKCNLAFQRDEK--------- 807
+S ++ V++ ++ + E+L ++ EE+ QR E+
Sbjct: 1276 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1335
Query: 808 VLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE-EIQSEKEALQSDLLEMKN 866
LE ++++ ++ Q E L+ QE+V+ R+E + Q +K ++Q +L +++
Sbjct: 1336 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1395
Query: 867 ANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRR---- 922
++E ++ +K+ E+ ++ E ++ + Q E +R+
Sbjct: 1396 SSE----------------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1439
Query: 923 -AELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKL-VAVKAKKE 980
EL L+ ++ + K ++ +E+ E L ++ +++ ++ + ++ +A + K E
Sbjct: 1440 EGELQALRARAEEAEAQK-------RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1492
Query: 981 LDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERA 1040
+++R E Q + LE LR + ++ +R + LE ++S + +++ +RA
Sbjct: 1493 AEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1551
Query: 1041 NNFEHRIEDLTRQLRNSTL-----------------QCETINSDNEDLLARIETLQSNAK 1083
+F + L R L+ + + E + E L R + + A
Sbjct: 1552 -SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1610
Query: 1084 LLEVQILEVQRAKAMVDKELEAEKLQKEQ------KIKEHATTVNELEELQVQLQK---E 1134
L +Q EV + K++ E E +K + E+ K +E A EL E +++ Q+ E
Sbjct: 1611 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1670
Query: 1135 KKQLQKTMQELELVKKDA------QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ 1188
Q+ E EL++ A QQ L+ E+A +R QK ++ +
Sbjct: 1671 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1730
Query: 1189 EIKIQKQKQETLQEEITSL-QSSVQQYEEKNTKIKQLL------------VKTKKELAD- 1234
E+++ + +EE S + S Q+ E + + ++L K +++LA+
Sbjct: 1731 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1790
Query: 1235 --SKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTL 1292
++Q +L L EA++ + E +I L E +E ++ + A Q +R
Sbjct: 1791 DAARQRAEAERVLAEKLAAIGEATRLKTEA-EIALKEKEAENERLRRLAEDEAFQRRRLE 1849
Query: 1293 SAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMS----QAETEGAK 1348
Q ++E R A+ +A+ SE E K V + L+Q++ +A E A
Sbjct: 1850 EQAAQHKADIEE--RLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1906
Query: 1349 QEREHLEMLIDQLKIKLQD---SQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA 1405
+ LE+ + +++ +D S+ ++ + + L +E + + +Q++++ E
Sbjct: 1907 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1966
Query: 1406 E-LREKLCSIQS-ENMMMKSEHTQTVSQLTSQNEVLRNSFRDQV--RHLQEEHR------ 1455
E R++ +++ E + K E + + + Q + + + LQ E +
Sbjct: 1967 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2026
Query: 1456 -KTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ-------------QSLKNLRERRNTD 1501
+ + LQQ L + ++ L QL+ E + + QS + + E
Sbjct: 2027 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2086
Query: 1502 LPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEEL 1561
+ + E E+ A+ Q+ + L + H +F ++ L
Sbjct: 2087 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146
Query: 1562 VQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERN--------------- 1606
QK + + L L ET+ +L E+++ LK+E R
Sbjct: 2147 RQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2205
Query: 1607 QEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQ 1661
+E K A +E L+ L+ +R L ++ EE +L+ AQ
Sbjct: 2206 EELSKLKARIEAENRALI----LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2256
Score = 43.1 bits (100), Expect = 0.002
Identities = 204/1030 (19%), Positives = 381/1030 (36%), Gaps = 177/1030 (17%)
Query: 721 KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV 780
K H+ LE++ QL E + E +Q++ K Q+ L E ++ + DV
Sbjct: 340 KLHVAILEREKQLRSEFE-------RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR 392
Query: 781 NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840
L A G+ + E + +L + D + L +++ L++ Q E++ + +
Sbjct: 393 --LLAAGKVPQRAGEVERDLD-KADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERL 449
Query: 841 VLLRKELE---EIQSEKEALQSDLLEMKNANEKTRLEN------QNLLIQVEEVSQTCSK 891
V +R E + A Q + +++ + LE+ Q+LL VEE
Sbjct: 450 VAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG 509
Query: 892 SE--IHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKEL 949
+E + + + H L +E+ + RA D SP+ + + L
Sbjct: 510 AEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR----SDEGQLSPATRGAYRDCLGRL 565
Query: 950 EEKIENLEKECKEKEEKINKIKLVAVKAKKELD-SSRKETQTV----KEELESLRSEKDQ 1004
+ + L K + + + A KEL + KE + V + ++ ++K+
Sbjct: 566 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 625
Query: 1005 LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1064
SA MR+L E + + E + ++L E A + + + LQ
Sbjct: 626 YSALMREL----ELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQ---- 677
Query: 1065 NSDNEDLLARIET-LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123
L IE L+ NA + +V+ A+ + K EA L+++ + + TV
Sbjct: 678 ------LCCCIEAHLKENAAYFQF-FSDVREAEGQLQKLQEA--LRRKYSC-DRSATVTR 727
Query: 1124 LEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN--------------MEIADYERLM 1169
LE+L Q EK+QL + L + K A+ + + + DY+++
Sbjct: 728 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE 787
Query: 1170 KELNQ---------------KLTNKNNKIEDLEQEIKIQKQKQETLQEEITSL----QSS 1210
+++ K+ + + + + + QE +T L Q+
Sbjct: 788 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 847
Query: 1211 VQQYEEKNTKIKQLL----------------VKTKKELADSKQAETDH---LILQASLKG 1251
V + + + +K LL + T + L +Q + H L QA L+
Sbjct: 848 VTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRD 907
Query: 1252 ELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQ------EE 1305
+A E + E S H ++ L S EQ + S Q+ ++ L+ E
Sbjct: 908 SQDAGGFGPEDRLMAEREYGSCSHH-YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEA 966
Query: 1306 CRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKL 1365
C + + + E + + +QQK +QAE EG + L +++
Sbjct: 967 CETRTVHRLRLPLDKEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALP 1022
Query: 1366 QDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEH 1425
+ S TL+SE + L + L++ S A EKL +I
Sbjct: 1023 EPS--------PAAPTLRSELELTLGK----LEQVRSLSAIYLEKLKTI----------- 1059
Query: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485
+ + EVLR EE K + + L ++EA
Sbjct: 1060 SLVIRGTQGAEEVLR---------AHEEQLKEAQAVPATLPELEA--------------- 1095
Query: 1486 SSQQSLKNLRERRNTDLP----LLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541
++ SLK LR + P L D +E GE ++ E + + + QLL
Sbjct: 1096 -TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1154
Query: 1542 SPETKL-EPPLWHAEFTKEELVQKLSSTTKSADHLNGLL----RETEATNAILMEQIKLL 1596
+ L + + E E+L ++L +SAD L L R E A+ + + +
Sbjct: 1155 RWQAVLAQTDVRQREL--EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1212
Query: 1597 KSEIRRLER-NQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSP-EEKG 1654
+ ++R+ + +E E+ +E + Q+I + ++ L ++ QL P
Sbjct: 1213 REQLRQEQALLEEIERHGEKVEECQRFAKQYI----NAIKDYELQLVTYKAQLEPVASPA 1268
Query: 1655 KLAAVAQGEE 1664
K V G E
Sbjct: 1269 KKPKVQSGSE 1278
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 216 bits (551), Expect = 1e-55
Identities = 366/1752 (20%), Positives = 716/1752 (40%), Gaps = 197/1752 (11%)
Query: 11 SPATPGTGKSKLE-TLPKEDLIKFAK-------KQMMLIQKAKSRCTEL----EKEIEEL 58
SPA P T +S+LE TL K + ++ K + L+ + E+ E++++E
Sbjct: 1194 SPAAP-TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1252
Query: 59 RSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKM-GDAH 117
++ P T + KA ++L A +AE +Q ++ ++ QEV + + + G+
Sbjct: 1253 QAVPATLPELEATKASLKKLRA----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1308
Query: 118 KELEQSHINYV-----------------KEIENLKNELMAVRSKYSEDKANLQ---KQLE 157
E+E+ +E+E L +L R A LQ ++ E
Sbjct: 1309 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1368
Query: 158 EAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVT 217
+ L S+ ++ Q E + L EEIE+ EE + ++ ++A D + + VT
Sbjct: 1369 QIQAMPLADSQAVREQLRQE---QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1425
Query: 218 QLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELK 277
+ S + + S E ++Q + EL K + ++ E +
Sbjct: 1426 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-E 1484
Query: 278 ENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHL 337
E L +Q A E+ + E LE R+ A Q + +E ++Q + E+V
Sbjct: 1485 ERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAEREAKELQQRMQEEVVRR 1541
Query: 338 EDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQ 397
E+ + + Q +++E + L+ E + Q K E +I E + Q
Sbjct: 1542 EEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQ-AKARQAEAAERSRLRIEEEIRVVRLQ 1597
Query: 398 GCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF 457
+E + + G + + E ++ K Q Q+E L +S++++ +
Sbjct: 1598 ---LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1653
Query: 458 EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFE-SMKQQQASDV 516
+K + E +EKQ A+ E LR E + L ++ + +++ + +++ Q S
Sbjct: 1654 LASRVKAEAE-AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712
Query: 517 HELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLS 576
ELQ K R +F EK A LE L + V +L + ++ +
Sbjct: 1713 AELQSK-RASFAEKTAQLE---------RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1762
Query: 577 QRDTMLKELEGKINS---LTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQ 633
+ + L+ + K N L + ++ + + E + ++ ERE R GK EQ
Sbjct: 1763 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR---RRGKAEEQ 1819
Query: 634 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV-------QMKVLSEDKEVLSAE 686
++ EQ++ + E T +++ +Q+L +L Q ++L E+ L E
Sbjct: 1820 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1879
Query: 687 VKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLE 746
+ ++ +L +E ++ ++EV L+ K + T EK Q + E +L E
Sbjct: 1880 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS-EKSKQRLEAEAGRFRELAE 1938
Query: 747 NE-QVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRD 805
+++ L + + L E + E+ + L A+GE+ E + L
Sbjct: 1939 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---- 1994
Query: 806 EKVLELEKEIKCLQEESVVQCEELKSLLR----DYEQEKVLLRKELEEIQSEKEALQSDL 861
EK E E+ ++ L E+ Q L+ D E+ LRK + ++ L D
Sbjct: 1995 EKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 2053
Query: 862 LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIH--------NEKEKCFIKEHENL---- 909
L ++ ++E + L ++ K+E+ N ++ KE L
Sbjct: 2054 LR-----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 2108
Query: 910 -KPLLEQKELRDRRAELILLKDSLAKSPSVKNDP--LSSVKELEEKIENLEK-ECKEKEE 965
+ L ++E R R AE + K A+ + + L V+ L+ K+E + + ++E
Sbjct: 2109 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2168
Query: 966 KINKIKLVAVKAKKELDSSRK--------ETQTVKEELESLRSEKDQLSASMRDLIQGAE 1017
+++L A+K L + K + Q +++ L+ +S DQL + AE
Sbjct: 2169 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2228
Query: 1018 SYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIET 1077
+ ++ E+++ Q + E A + E+ + + E + + E AR
Sbjct: 2229 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2288
Query: 1078 LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQ 1137
+ A R K D E+E K EQ +++ A EL L++QL++ Q
Sbjct: 2289 AEQAAL----------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2338
Query: 1138 LQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQ 1197
+EL+ +K +A + ++ + ++ ++L+ +IE E I + K
Sbjct: 2339 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE-AENRALILRDKD 2397
Query: 1198 ET---LQEEITSLQSSVQQYE------EKNTKIKQLL---VKTKKELADSKQAETDHLIL 1245
T LQEE ++ ++ ++ +++QL + ++ LA+ E +
Sbjct: 2398 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2457
Query: 1246 QAS-LKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQE 1304
+A+ LK E E QQQ E+ + Q + +K ++ + L + QRTL A +QR
Sbjct: 2458 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR------ 2511
Query: 1305 ECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL-KI 1363
Q +++E E K+RV + +++ ++AE E A++ R+ E + ++L +
Sbjct: 2512 --------QLEMSAEAERLKLRV-----AEMSRAQARAE-EDAQRFRKQAEEIGEKLHRT 2557
Query: 1364 KLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS 1423
+L + + E+Q QS+HD + L+E +++ +EKL +++ + +KS
Sbjct: 2558 ELATQEKVTLVQTLEIQRQQSDHDA------ERLREAIAELEREKEKL-QQEAKLLQLKS 2610
Query: 1424 EHTQTV--SQLTSQNEVLRNSFRDQ-------VRHLQEEHRKTVETLQQQLSKMEAQLFQ 1474
E QTV QL + + L+ SF + R +++E K + Q +++K + QL +
Sbjct: 2611 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ-QLRE 2669
Query: 1475 LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQ 1534
+ + Q+ + ++ E R + +EE + +E + + Q
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2729
Query: 1535 SLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAI------ 1588
L + L E + L H+E V + D L+G E E ++
Sbjct: 2730 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2789
Query: 1589 -----LMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVL-----LQFIFLKPGSERERL 1638
L E L E++RL + A E +++ L + + LK +E+ +
Sbjct: 2790 VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2849
Query: 1639 LPVINTMLQLSP 1650
+ L LSP
Sbjct: 2850 YAALQRQL-LSP 2860
Score = 145 bits (365), Expect = 4e-34
Identities = 355/1856 (19%), Positives = 712/1856 (38%), Gaps = 335/1856 (18%)
Query: 7 DGVASPATPGTGKSKLETLPKE--DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVT 64
+G SPAT G + L L + L+ +K ++ ++ S KE+ L K
Sbjct: 716 EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE 775
Query: 65 EGTGDI------IKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMG---- 114
E D + A E AL+ E L LK++ IK Q D + +
Sbjct: 776 EVGFDWSDRNTNMTAKKESYSALMRE--------LELKEKKIKELQNAGDRLLREDHPAR 827
Query: 115 ------------------------DAHKELEQSHINYVKEIENLKNELM----AVRSKYS 146
+AH + ++ + ++ + +L A+R KYS
Sbjct: 828 PTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 887
Query: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
D++ +LE+ + + EQL + K + + +++P + + L
Sbjct: 888 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLL 947
Query: 207 ATTDEKKETVT-----QLQNIIEANSQHYQKNINSLQEELLQ----LKAIHQEEVKELMC 257
A D K+ VT + Q + A H++ +S E + L +E +E +
Sbjct: 948 AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 1007
Query: 258 QIEASAKEHEAEINKLNELKENL--VKQCEASEKNIQKKYECELENLRKATSNANQDNQI 315
++EA +H+A + ++L ++ + ++ +++Q L R Q +
Sbjct: 1008 RLEA---QHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR-TLKPEEQRQAL 1063
Query: 316 CSILLQENTFV-----------------EQVVNEKVKHLEDTLKELESQH---------- 348
S+ L F+ E+ H + L+ LE
Sbjct: 1064 HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 1123
Query: 349 SILKD--------EVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKIN------------ 388
S LKD E ++ L+L L+ + + E++ + ++
Sbjct: 1124 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1183
Query: 389 -ELLLAKEEQGCVIEKLKSE-------------LAGLNKQFCYTVEQHNREVQSLKE--- 431
E +LA E L+SE L+ + + T+ R Q +E
Sbjct: 1184 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1243
Query: 432 QHQKEISE-------LNETFLSDSEKEKLTLMFEIQ------------GLKEQCENLQQE 472
H++++ E L E + + +KL E Q G +E E LQQ
Sbjct: 1244 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1303
Query: 473 KQEAILNYESLREIM--------------EILQTELGESAGKISQEFES----------- 507
E + E RE + ++ Q EL + ++ ES
Sbjct: 1304 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1363
Query: 508 ---MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNL 564
+Q QA + + Q +R ++ ALLE + R EK+ Q + N IK+
Sbjct: 1364 RRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1419
Query: 565 QEKNGVYLLSLS-------------------QRDTMLKELEGKINSLTEEKDDFINKLKN 605
+ + Y L Q L+ ++ +LT + FI++
Sbjct: 1420 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1479
Query: 606 SHEEMDNF--HKKCEREERL-----ILELGKKV--------EQTIQYNSELEQKVNELTG 650
EE + ++ E ERL LE +++ Q + EL+Q++ E
Sbjct: 1480 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539
Query: 651 GLEETLKEKDQNDQKLEKLMVQMKVLSE-DKEVLSAEVKSLYEENNKLSSEKKQLSRDLE 709
EE + Q + +++ + Q++ SE + + + + ++ ++ E + + LE
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1599
Query: 710 VFLSQK-----EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLK 764
Q+ E L+ + E + + EE + L + +++E +K + +L +K
Sbjct: 1600 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1659
Query: 765 EMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVV 824
+E ++ LQA+ E + E + L E+ +++ ++ Q +
Sbjct: 1660 ------AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1713
Query: 825 QCEELKSLLRDYEQEKVLLRKELEE-------IQSEKEALQSDLLEMKNANEKTRLENQ- 876
EL+S + ++ L + L+E ++ E E E + A E+ E +
Sbjct: 1714 ---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770
Query: 877 ---------NLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELIL 927
L +Q EEV+Q S ++ EK+K + + E++ +R R L
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----L 1826
Query: 928 LKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
+ L K + E+++ L E ++ E++ ++ + ++E ++ ++
Sbjct: 1827 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1886
Query: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
Q ++ EL +R+E + L AS + + S EK ++L+ E R
Sbjct: 1887 RQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEAEAGRFRELAEEA 1940
Query: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIETL--QSNAKLLEVQILEVQRAKAMVDKELEA 1105
L + Q + D A E + + A + E L+ + A+ +KE E
Sbjct: 1941 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 2000
Query: 1106 EKLQK------------EQKIKEHATTVNE-LEELQ----VQLQKEKKQLQKTMQELELV 1148
E+L++ E++ +H + E L +L+ +L+++K ++ T+++ V
Sbjct: 2001 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 2060
Query: 1149 KKD-AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ-EIKIQKQKQETLQEEITS 1206
+++ A L EL + +N + + EQ E++ +Q+Q +EE
Sbjct: 2061 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE--- 2117
Query: 1207 LQSSVQQYEEKNTKIKQLLVKTKKELADSKQA--ETDHLILQASLKGELEASQQQVEVYK 1264
++ E ++++ L ++ K A E + L + L +Q +
Sbjct: 2118 -----RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2172
Query: 1265 IQLAEITSEK-----HKIHEHLKTSAEQH-QRTLSAYQQRVTALQEECRAAK-----AEQ 1313
+QLA+ ++K K H EQ Q+TL Q + L+ E AA+ AE+
Sbjct: 2173 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232
Query: 1314 ATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ 1373
A V +E E+ + R V + ++ K ++ + + Q + E L + + Q++ Q
Sbjct: 2233 ARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE---QEAARRAQ 2288
Query: 1374 INVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLT 1433
+ L+ Q+ D +E+H K ++T+ ++A++ ++L +++ + + +++H + +
Sbjct: 2289 AEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEETDHQKNLLDEE 2345
Query: 1434 SQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKN 1493
Q + + R EE +V ++LSK++A++ E R+ +
Sbjct: 2346 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-----EAENRALI-------- 2392
Query: 1494 LRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWH 1553
LR++ NT L +EE E M+ E + S Q +L E L
Sbjct: 2393 LRDKDNTQRFL-------QEEAEKMKQV-AEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2444
Query: 1554 AEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQER 1609
AE +E +Q + T+ +A +L +Q +L + + RRL+ ++E+
Sbjct: 2445 AEKMLKEKMQAVQEATR-----------LKAEAELLQQQKELAQEQARRLQEDKEQ 2489
Score = 133 bits (335), Expect = 1e-30
Identities = 333/1795 (18%), Positives = 703/1795 (39%), Gaps = 298/1795 (16%)
Query: 109 SVTKMGDAHKELEQSHINYVKEIENLKNE----LMAVRSKYSEDKANLQKQLEEAMNTQL 164
SV +H+ L QS + +IE +++ A R Y + L Q + +N+
Sbjct: 687 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSS- 745
Query: 165 ELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIE 224
+L+ + V +E+ + EE++ + + KKE+ + L +E
Sbjct: 746 --KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 803
Query: 225 ANSQHYQKNINSLQEELLQ-----------LKAIHQEE---VKELMCQIEASAKEHEAEI 270
+ K + + + LL+ +A Q + + +L C IEA KE+ A
Sbjct: 804 LKEKKI-KELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 862
Query: 271 NKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVV 330
++++E Q + ++ +++KY C+ R AT +D LLQ+ ++ +
Sbjct: 863 QFFSDVRE-AEGQLQKLQEALRRKYSCD----RSATVTRLED------LLQDAQDEKEQL 911
Query: 331 NEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINEL 390
NE HL K ++ + + +L L + + E + D + +
Sbjct: 912 NEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGD---ECQLV 968
Query: 391 LLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQS----LKEQHQKEISELNETFLS 446
A+ V+ SE A C+ V N+E Q L+ QHQ ++ ++ +
Sbjct: 969 GPAQPSHWKVLSSSGSEAA--VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 1026
Query: 447 -DSEKEKLTLMFEIQGLKE---------QCENLQQEKQEAILNYES-LREIME------- 488
S +L ++Q ++ + E +Q L+Y++ LR+ +
Sbjct: 1027 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 1086
Query: 489 ---ILQTELGESAGKISQEFESMK---------QQQASDVHELQQKLRTAFT-------- 528
+ + E G + Q +S++ Q+ S++ +++ +L T
Sbjct: 1087 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1146
Query: 529 --EKDALLETVNRL--------------------QGENEKLLSQQELVP-------ELEN 559
+K+ E R+ E EK+L+ E P ELE
Sbjct: 1147 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1206
Query: 560 TIKNLQE---KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDF----------------- 599
T+ L++ + +YL L +++ +G L ++
Sbjct: 1207 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1266
Query: 600 --INKLKNSHEEMDNFHKKCEREERLILELGKKVEQTI-QYNSELE---QKVNELTGGLE 653
+ KL+ E E R E+G++++Q + + E+E ++V +L +
Sbjct: 1267 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1326
Query: 654 ETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLS 713
L + D ++LE+L Q++ E + L A ++ ++ + S+ + L
Sbjct: 1327 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1386
Query: 714 QKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGF---LKEMGSEV 770
Q++ L E I + +K++ +++ ++Q + K QL K+ +
Sbjct: 1387 QEQ--ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1444
Query: 771 SEDSEEKDVVNV--------------LQAVGESLAKINEEKCNLAFQRDEK--------- 807
+S ++ V++ ++ + E+L ++ EE+ QR E+
Sbjct: 1445 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1504
Query: 808 VLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE-EIQSEKEALQSDLLEMKN 866
LE ++++ ++ Q E L+ QE+V+ R+E + Q +K ++Q +L +++
Sbjct: 1505 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1564
Query: 867 ANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRR---- 922
++E ++ +K+ E+ ++ E ++ + Q E +R+
Sbjct: 1565 SSE----------------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1608
Query: 923 -AELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKL-VAVKAKKE 980
EL L+ ++ + K ++ +E+ E L ++ +++ ++ + ++ +A + K E
Sbjct: 1609 EGELQALRARAEEAEAQK-------RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1661
Query: 981 LDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERA 1040
+++R E Q + LE LR + ++ +R + LE ++S + +++ +RA
Sbjct: 1662 AEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1720
Query: 1041 NNFEHRIEDLTRQLRNSTL-----------------QCETINSDNEDLLARIETLQSNAK 1083
+F + L R L+ + + E + E L R + + A
Sbjct: 1721 -SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1779
Query: 1084 LLEVQILEVQRAKAMVDKELEAEKLQKEQ------KIKEHATTVNELEELQVQLQK---E 1134
L +Q EV + K++ E E +K + E+ K +E A EL E +++ Q+ E
Sbjct: 1780 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1839
Query: 1135 KKQLQKTMQELELVKKDA------QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ 1188
Q+ E EL++ A QQ L+ E+A +R QK ++ +
Sbjct: 1840 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1899
Query: 1189 EIKIQKQKQETLQEEITSL-QSSVQQYEEKNTKIKQLL------------VKTKKELAD- 1234
E+++ + +EE S + S Q+ E + + ++L K +++LA+
Sbjct: 1900 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1959
Query: 1235 --SKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTL 1292
++Q +L L EA++ + E +I L E +E ++ + A Q +R
Sbjct: 1960 DAARQRAEAERVLAEKLAAIGEATRLKTEA-EIALKEKEAENERLRRLAEDEAFQRRRLE 2018
Query: 1293 SAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMS----QAETEGAK 1348
Q ++E R A+ +A+ SE E K V + L+Q++ +A E A
Sbjct: 2019 EQAAQHKADIEE--RLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 2075
Query: 1349 QEREHLEMLIDQLKIKLQD---SQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA 1405
+ LE+ + +++ +D S+ ++ + + L +E + + +Q++++ E
Sbjct: 2076 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2135
Query: 1406 E-LREKLCSIQS-ENMMMKSEHTQTVSQLTSQNEVLRNSFRDQV--RHLQEEHR------ 1455
E R++ +++ E + K E + + + Q + + + LQ E +
Sbjct: 2136 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2195
Query: 1456 -KTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ-------------QSLKNLRERRNTD 1501
+ + LQQ L + ++ L QL+ E + + QS + + E
Sbjct: 2196 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2255
Query: 1502 LPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEEL 1561
+ + E E+ A+ Q+ + L + H +F ++ L
Sbjct: 2256 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315
Query: 1562 VQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERN--------------- 1606
QK + + L L ET+ +L E+++ LK+E R
Sbjct: 2316 RQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2374
Query: 1607 QEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQ 1661
+E K A +E L+ L+ +R L ++ EE +L+ AQ
Sbjct: 2375 EELSKLKARIEAENRALI----LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2425
Score = 43.1 bits (100), Expect = 0.002
Identities = 204/1030 (19%), Positives = 381/1030 (36%), Gaps = 177/1030 (17%)
Query: 721 KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV 780
K H+ LE++ QL E + E +Q++ K Q+ L E ++ + DV
Sbjct: 509 KLHVAILEREKQLRSEFE-------RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR 561
Query: 781 NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840
L A G+ + E + +L + D + L +++ L++ Q E++ + +
Sbjct: 562 --LLAAGKVPQRAGEVERDLD-KADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERL 618
Query: 841 VLLRKELE---EIQSEKEALQSDLLEMKNANEKTRLEN------QNLLIQVEEVSQTCSK 891
V +R E + A Q + +++ + LE+ Q+LL VEE
Sbjct: 619 VAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG 678
Query: 892 SE--IHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKEL 949
+E + + + H L +E+ + RA D SP+ + + L
Sbjct: 679 AEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR----SDEGQLSPATRGAYRDCLGRL 734
Query: 950 EEKIENLEKECKEKEEKINKIKLVAVKAKKELD-SSRKETQTV----KEELESLRSEKDQ 1004
+ + L K + + + A KEL + KE + V + ++ ++K+
Sbjct: 735 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 794
Query: 1005 LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1064
SA MR+L E + + E + ++L E A + + + LQ
Sbjct: 795 YSALMREL----ELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQ---- 846
Query: 1065 NSDNEDLLARIET-LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123
L IE L+ NA + +V+ A+ + K EA L+++ + + TV
Sbjct: 847 ------LCCCIEAHLKENAAYFQF-FSDVREAEGQLQKLQEA--LRRKYSC-DRSATVTR 896
Query: 1124 LEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN--------------MEIADYERLM 1169
LE+L Q EK+QL + L + K A+ + + + DY+++
Sbjct: 897 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE 956
Query: 1170 KELNQ---------------KLTNKNNKIEDLEQEIKIQKQKQETLQEEITSL----QSS 1210
+++ K+ + + + + + QE +T L Q+
Sbjct: 957 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 1016
Query: 1211 VQQYEEKNTKIKQLL----------------VKTKKELADSKQAETDH---LILQASLKG 1251
V + + + +K LL + T + L +Q + H L QA L+
Sbjct: 1017 VTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRD 1076
Query: 1252 ELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQ------EE 1305
+A E + E S H ++ L S EQ + S Q+ ++ L+ E
Sbjct: 1077 SQDAGGFGPEDRLMAEREYGSCSHH-YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEA 1135
Query: 1306 CRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKL 1365
C + + + E + + +QQK +QAE EG + L +++
Sbjct: 1136 CETRTVHRLRLPLDKEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALP 1191
Query: 1366 QDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEH 1425
+ S TL+SE + L + L++ S A EKL +I
Sbjct: 1192 EPS--------PAAPTLRSELELTLGK----LEQVRSLSAIYLEKLKTI----------- 1228
Query: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485
+ + EVLR EE K + + L ++EA
Sbjct: 1229 SLVIRGTQGAEEVLR---------AHEEQLKEAQAVPATLPELEA--------------- 1264
Query: 1486 SSQQSLKNLRERRNTDLP----LLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541
++ SLK LR + P L D +E GE ++ E + + + QLL
Sbjct: 1265 -TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1323
Query: 1542 SPETKL-EPPLWHAEFTKEELVQKLSSTTKSADHLNGLL----RETEATNAILMEQIKLL 1596
+ L + + E E+L ++L +SAD L L R E A+ + + +
Sbjct: 1324 RWQAVLAQTDVRQREL--EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1381
Query: 1597 KSEIRRLER-NQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSP-EEKG 1654
+ ++R+ + +E E+ +E + Q+I + ++ L ++ QL P
Sbjct: 1382 REQLRQEQALLEEIERHGEKVEECQRFAKQYI----NAIKDYELQLVTYKAQLEPVASPA 1437
Query: 1655 KLAAVAQGEE 1664
K V G E
Sbjct: 1438 KKPKVQSGSE 1447
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 216 bits (551), Expect = 1e-55
Identities = 366/1752 (20%), Positives = 716/1752 (40%), Gaps = 197/1752 (11%)
Query: 11 SPATPGTGKSKLE-TLPKEDLIKFAK-------KQMMLIQKAKSRCTEL----EKEIEEL 58
SPA P T +S+LE TL K + ++ K + L+ + E+ E++++E
Sbjct: 1035 SPAAP-TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1093
Query: 59 RSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKM-GDAH 117
++ P T + KA ++L A +AE +Q ++ ++ QEV + + + G+
Sbjct: 1094 QAVPATLPELEATKASLKKLRA----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1149
Query: 118 KELEQSHINYV-----------------KEIENLKNELMAVRSKYSEDKANLQ---KQLE 157
E+E+ +E+E L +L R A LQ ++ E
Sbjct: 1150 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1209
Query: 158 EAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVT 217
+ L S+ ++ Q E + L EEIE+ EE + ++ ++A D + + VT
Sbjct: 1210 QIQAMPLADSQAVREQLRQE---QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1266
Query: 218 QLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELK 277
+ S + + S E ++Q + EL K + ++ E +
Sbjct: 1267 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-E 1325
Query: 278 ENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHL 337
E L +Q A E+ + E LE R+ A Q + +E ++Q + E+V
Sbjct: 1326 ERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAEREAKELQQRMQEEVVRR 1382
Query: 338 EDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQ 397
E+ + + Q +++E + L+ E + Q K E +I E + Q
Sbjct: 1383 EEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQ-AKARQAEAAERSRLRIEEEIRVVRLQ 1438
Query: 398 GCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF 457
+E + + G + + E ++ K Q Q+E L +S++++ +
Sbjct: 1439 ---LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1494
Query: 458 EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFE-SMKQQQASDV 516
+K + E +EKQ A+ E LR E + L ++ + +++ + +++ Q S
Sbjct: 1495 LASRVKAEAE-AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
Query: 517 HELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLS 576
ELQ K R +F EK A LE L + V +L + ++ +
Sbjct: 1554 AELQSK-RASFAEKTAQLE---------RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1603
Query: 577 QRDTMLKELEGKINS---LTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQ 633
+ + L+ + K N L + ++ + + E + ++ ERE R GK EQ
Sbjct: 1604 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR---RRGKAEEQ 1660
Query: 634 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV-------QMKVLSEDKEVLSAE 686
++ EQ++ + E T +++ +Q+L +L Q ++L E+ L E
Sbjct: 1661 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1720
Query: 687 VKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLE 746
+ ++ +L +E ++ ++EV L+ K + T EK Q + E +L E
Sbjct: 1721 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS-EKSKQRLEAEAGRFRELAE 1779
Query: 747 NE-QVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRD 805
+++ L + + L E + E+ + L A+GE+ E + L
Sbjct: 1780 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---- 1835
Query: 806 EKVLELEKEIKCLQEESVVQCEELKSLLR----DYEQEKVLLRKELEEIQSEKEALQSDL 861
EK E E+ ++ L E+ Q L+ D E+ LRK + ++ L D
Sbjct: 1836 EKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1894
Query: 862 LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIH--------NEKEKCFIKEHENL---- 909
L ++ ++E + L ++ K+E+ N ++ KE L
Sbjct: 1895 LR-----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1949
Query: 910 -KPLLEQKELRDRRAELILLKDSLAKSPSVKNDP--LSSVKELEEKIENLEK-ECKEKEE 965
+ L ++E R R AE + K A+ + + L V+ L+ K+E + + ++E
Sbjct: 1950 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2009
Query: 966 KINKIKLVAVKAKKELDSSRK--------ETQTVKEELESLRSEKDQLSASMRDLIQGAE 1017
+++L A+K L + K + Q +++ L+ +S DQL + AE
Sbjct: 2010 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2069
Query: 1018 SYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIET 1077
+ ++ E+++ Q + E A + E+ + + E + + E AR
Sbjct: 2070 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2129
Query: 1078 LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQ 1137
+ A R K D E+E K EQ +++ A EL L++QL++ Q
Sbjct: 2130 AEQAAL----------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2179
Query: 1138 LQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQ 1197
+EL+ +K +A + ++ + ++ ++L+ +IE E I + K
Sbjct: 2180 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE-AENRALILRDKD 2238
Query: 1198 ET---LQEEITSLQSSVQQYE------EKNTKIKQLL---VKTKKELADSKQAETDHLIL 1245
T LQEE ++ ++ ++ +++QL + ++ LA+ E +
Sbjct: 2239 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2298
Query: 1246 QAS-LKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQE 1304
+A+ LK E E QQQ E+ + Q + +K ++ + L + QRTL A +QR
Sbjct: 2299 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR------ 2352
Query: 1305 ECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL-KI 1363
Q +++E E K+RV + +++ ++AE E A++ R+ E + ++L +
Sbjct: 2353 --------QLEMSAEAERLKLRV-----AEMSRAQARAE-EDAQRFRKQAEEIGEKLHRT 2398
Query: 1364 KLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS 1423
+L + + E+Q QS+HD + L+E +++ +EKL +++ + +KS
Sbjct: 2399 ELATQEKVTLVQTLEIQRQQSDHDA------ERLREAIAELEREKEKL-QQEAKLLQLKS 2451
Query: 1424 EHTQTV--SQLTSQNEVLRNSFRDQ-------VRHLQEEHRKTVETLQQQLSKMEAQLFQ 1474
E QTV QL + + L+ SF + R +++E K + Q +++K + QL +
Sbjct: 2452 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ-QLRE 2510
Query: 1475 LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQ 1534
+ + Q+ + ++ E R + +EE + +E + + Q
Sbjct: 2511 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2570
Query: 1535 SLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAI------ 1588
L + L E + L H+E V + D L+G E E ++
Sbjct: 2571 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2630
Query: 1589 -----LMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVL-----LQFIFLKPGSERERL 1638
L E L E++RL + A E +++ L + + LK +E+ +
Sbjct: 2631 VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2690
Query: 1639 LPVINTMLQLSP 1650
+ L LSP
Sbjct: 2691 YAALQRQL-LSP 2701
Score = 145 bits (365), Expect = 4e-34
Identities = 355/1856 (19%), Positives = 712/1856 (38%), Gaps = 335/1856 (18%)
Query: 7 DGVASPATPGTGKSKLETLPKE--DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVT 64
+G SPAT G + L L + L+ +K ++ ++ S KE+ L K
Sbjct: 557 EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE 616
Query: 65 EGTGDI------IKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMG---- 114
E D + A E AL+ E L LK++ IK Q D + +
Sbjct: 617 EVGFDWSDRNTNMTAKKESYSALMRE--------LELKEKKIKELQNAGDRLLREDHPAR 668
Query: 115 ------------------------DAHKELEQSHINYVKEIENLKNELM----AVRSKYS 146
+AH + ++ + ++ + +L A+R KYS
Sbjct: 669 PTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 728
Query: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
D++ +LE+ + + EQL + K + + +++P + + L
Sbjct: 729 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLL 788
Query: 207 ATTDEKKETVT-----QLQNIIEANSQHYQKNINSLQEELLQ----LKAIHQEEVKELMC 257
A D K+ VT + Q + A H++ +S E + L +E +E +
Sbjct: 789 AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 848
Query: 258 QIEASAKEHEAEINKLNELKENL--VKQCEASEKNIQKKYECELENLRKATSNANQDNQI 315
++EA +H+A + ++L ++ + ++ +++Q L R Q +
Sbjct: 849 RLEA---QHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR-TLKPEEQRQAL 904
Query: 316 CSILLQENTFV-----------------EQVVNEKVKHLEDTLKELESQH---------- 348
S+ L F+ E+ H + L+ LE
Sbjct: 905 HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 964
Query: 349 SILKD--------EVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKIN------------ 388
S LKD E ++ L+L L+ + + E++ + ++
Sbjct: 965 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1024
Query: 389 -ELLLAKEEQGCVIEKLKSE-------------LAGLNKQFCYTVEQHNREVQSLKE--- 431
E +LA E L+SE L+ + + T+ R Q +E
Sbjct: 1025 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1084
Query: 432 QHQKEISE-------LNETFLSDSEKEKLTLMFEIQ------------GLKEQCENLQQE 472
H++++ E L E + + +KL E Q G +E E LQQ
Sbjct: 1085 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1144
Query: 473 KQEAILNYESLREIM--------------EILQTELGESAGKISQEFES----------- 507
E + E RE + ++ Q EL + ++ ES
Sbjct: 1145 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1204
Query: 508 ---MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNL 564
+Q QA + + Q +R ++ ALLE + R EK+ Q + N IK+
Sbjct: 1205 RRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1260
Query: 565 QEKNGVYLLSLS-------------------QRDTMLKELEGKINSLTEEKDDFINKLKN 605
+ + Y L Q L+ ++ +LT + FI++
Sbjct: 1261 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1320
Query: 606 SHEEMDNF--HKKCEREERL-----ILELGKKV--------EQTIQYNSELEQKVNELTG 650
EE + ++ E ERL LE +++ Q + EL+Q++ E
Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380
Query: 651 GLEETLKEKDQNDQKLEKLMVQMKVLSE-DKEVLSAEVKSLYEENNKLSSEKKQLSRDLE 709
EE + Q + +++ + Q++ SE + + + + ++ ++ E + + LE
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440
Query: 710 VFLSQK-----EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLK 764
Q+ E L+ + E + + EE + L + +++E +K + +L +K
Sbjct: 1441 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1500
Query: 765 EMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVV 824
+E ++ LQA+ E + E + L E+ +++ ++ Q +
Sbjct: 1501 ------AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1554
Query: 825 QCEELKSLLRDYEQEKVLLRKELEE-------IQSEKEALQSDLLEMKNANEKTRLENQ- 876
EL+S + ++ L + L+E ++ E E E + A E+ E +
Sbjct: 1555 ---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611
Query: 877 ---------NLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELIL 927
L +Q EEV+Q S ++ EK+K + + E++ +R R L
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----L 1667
Query: 928 LKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
+ L K + E+++ L E ++ E++ ++ + ++E ++ ++
Sbjct: 1668 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1727
Query: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
Q ++ EL +R+E + L AS + + S EK ++L+ E R
Sbjct: 1728 RQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEAEAGRFRELAEEA 1781
Query: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIETL--QSNAKLLEVQILEVQRAKAMVDKELEA 1105
L + Q + D A E + + A + E L+ + A+ +KE E
Sbjct: 1782 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1841
Query: 1106 EKLQK------------EQKIKEHATTVNE-LEELQ----VQLQKEKKQLQKTMQELELV 1148
E+L++ E++ +H + E L +L+ +L+++K ++ T+++ V
Sbjct: 1842 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1901
Query: 1149 KKD-AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ-EIKIQKQKQETLQEEITS 1206
+++ A L EL + +N + + EQ E++ +Q+Q +EE
Sbjct: 1902 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE--- 1958
Query: 1207 LQSSVQQYEEKNTKIKQLLVKTKKELADSKQA--ETDHLILQASLKGELEASQQQVEVYK 1264
++ E ++++ L ++ K A E + L + L +Q +
Sbjct: 1959 -----RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2013
Query: 1265 IQLAEITSEK-----HKIHEHLKTSAEQH-QRTLSAYQQRVTALQEECRAAK-----AEQ 1313
+QLA+ ++K K H EQ Q+TL Q + L+ E AA+ AE+
Sbjct: 2014 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073
Query: 1314 ATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ 1373
A V +E E+ + R V + ++ K ++ + + Q + E L + + Q++ Q
Sbjct: 2074 ARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE---QEAARRAQ 2129
Query: 1374 INVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLT 1433
+ L+ Q+ D +E+H K ++T+ ++A++ ++L +++ + + +++H + +
Sbjct: 2130 AEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEETDHQKNLLDEE 2186
Query: 1434 SQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKN 1493
Q + + R EE +V ++LSK++A++ E R+ +
Sbjct: 2187 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-----EAENRALI-------- 2233
Query: 1494 LRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWH 1553
LR++ NT L +EE E M+ E + S Q +L E L
Sbjct: 2234 LRDKDNTQRFL-------QEEAEKMKQV-AEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2285
Query: 1554 AEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQER 1609
AE +E +Q + T+ +A +L +Q +L + + RRL+ ++E+
Sbjct: 2286 AEKMLKEKMQAVQEATR-----------LKAEAELLQQQKELAQEQARRLQEDKEQ 2330
Score = 133 bits (335), Expect = 1e-30
Identities = 333/1795 (18%), Positives = 703/1795 (39%), Gaps = 298/1795 (16%)
Query: 109 SVTKMGDAHKELEQSHINYVKEIENLKNE----LMAVRSKYSEDKANLQKQLEEAMNTQL 164
SV +H+ L QS + +IE +++ A R Y + L Q + +N+
Sbjct: 528 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSS- 586
Query: 165 ELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIE 224
+L+ + V +E+ + EE++ + + KKE+ + L +E
Sbjct: 587 --KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 644
Query: 225 ANSQHYQKNINSLQEELLQ-----------LKAIHQEE---VKELMCQIEASAKEHEAEI 270
+ K + + + LL+ +A Q + + +L C IEA KE+ A
Sbjct: 645 LKEKKI-KELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 703
Query: 271 NKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVV 330
++++E Q + ++ +++KY C+ R AT +D LLQ+ ++ +
Sbjct: 704 QFFSDVRE-AEGQLQKLQEALRRKYSCD----RSATVTRLED------LLQDAQDEKEQL 752
Query: 331 NEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINEL 390
NE HL K ++ + + +L L + + E + D + +
Sbjct: 753 NEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGD---ECQLV 809
Query: 391 LLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQS----LKEQHQKEISELNETFLS 446
A+ V+ SE A C+ V N+E Q L+ QHQ ++ ++ +
Sbjct: 810 GPAQPSHWKVLSSSGSEAA--VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 867
Query: 447 -DSEKEKLTLMFEIQGLKE---------QCENLQQEKQEAILNYES-LREIME------- 488
S +L ++Q ++ + E +Q L+Y++ LR+ +
Sbjct: 868 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 927
Query: 489 ---ILQTELGESAGKISQEFESMK---------QQQASDVHELQQKLRTAFT-------- 528
+ + E G + Q +S++ Q+ S++ +++ +L T
Sbjct: 928 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 987
Query: 529 --EKDALLETVNRL--------------------QGENEKLLSQQELVP-------ELEN 559
+K+ E R+ E EK+L+ E P ELE
Sbjct: 988 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1047
Query: 560 TIKNLQE---KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDF----------------- 599
T+ L++ + +YL L +++ +G L ++
Sbjct: 1048 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1107
Query: 600 --INKLKNSHEEMDNFHKKCEREERLILELGKKVEQTI-QYNSELE---QKVNELTGGLE 653
+ KL+ E E R E+G++++Q + + E+E ++V +L +
Sbjct: 1108 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1167
Query: 654 ETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLS 713
L + D ++LE+L Q++ E + L A ++ ++ + S+ + L
Sbjct: 1168 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1227
Query: 714 QKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGF---LKEMGSEV 770
Q++ L E I + +K++ +++ ++Q + K QL K+ +
Sbjct: 1228 QEQ--ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1285
Query: 771 SEDSEEKDVVNV--------------LQAVGESLAKINEEKCNLAFQRDEK--------- 807
+S ++ V++ ++ + E+L ++ EE+ QR E+
Sbjct: 1286 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1345
Query: 808 VLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE-EIQSEKEALQSDLLEMKN 866
LE ++++ ++ Q E L+ QE+V+ R+E + Q +K ++Q +L +++
Sbjct: 1346 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1405
Query: 867 ANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRR---- 922
++E ++ +K+ E+ ++ E ++ + Q E +R+
Sbjct: 1406 SSE----------------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1449
Query: 923 -AELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKL-VAVKAKKE 980
EL L+ ++ + K ++ +E+ E L ++ +++ ++ + ++ +A + K E
Sbjct: 1450 EGELQALRARAEEAEAQK-------RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1502
Query: 981 LDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERA 1040
+++R E Q + LE LR + ++ +R + LE ++S + +++ +RA
Sbjct: 1503 AEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1561
Query: 1041 NNFEHRIEDLTRQLRNSTL-----------------QCETINSDNEDLLARIETLQSNAK 1083
+F + L R L+ + + E + E L R + + A
Sbjct: 1562 -SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1620
Query: 1084 LLEVQILEVQRAKAMVDKELEAEKLQKEQ------KIKEHATTVNELEELQVQLQK---E 1134
L +Q EV + K++ E E +K + E+ K +E A EL E +++ Q+ E
Sbjct: 1621 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1680
Query: 1135 KKQLQKTMQELELVKKDA------QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ 1188
Q+ E EL++ A QQ L+ E+A +R QK ++ +
Sbjct: 1681 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1740
Query: 1189 EIKIQKQKQETLQEEITSL-QSSVQQYEEKNTKIKQLL------------VKTKKELAD- 1234
E+++ + +EE S + S Q+ E + + ++L K +++LA+
Sbjct: 1741 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1800
Query: 1235 --SKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTL 1292
++Q +L L EA++ + E +I L E +E ++ + A Q +R
Sbjct: 1801 DAARQRAEAERVLAEKLAAIGEATRLKTEA-EIALKEKEAENERLRRLAEDEAFQRRRLE 1859
Query: 1293 SAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMS----QAETEGAK 1348
Q ++E R A+ +A+ SE E K V + L+Q++ +A E A
Sbjct: 1860 EQAAQHKADIEE--RLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1916
Query: 1349 QEREHLEMLIDQLKIKLQD---SQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA 1405
+ LE+ + +++ +D S+ ++ + + L +E + + +Q++++ E
Sbjct: 1917 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1976
Query: 1406 E-LREKLCSIQS-ENMMMKSEHTQTVSQLTSQNEVLRNSFRDQV--RHLQEEHR------ 1455
E R++ +++ E + K E + + + Q + + + LQ E +
Sbjct: 1977 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2036
Query: 1456 -KTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ-------------QSLKNLRERRNTD 1501
+ + LQQ L + ++ L QL+ E + + QS + + E
Sbjct: 2037 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2096
Query: 1502 LPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEEL 1561
+ + E E+ A+ Q+ + L + H +F ++ L
Sbjct: 2097 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156
Query: 1562 VQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERN--------------- 1606
QK + + L L ET+ +L E+++ LK+E R
Sbjct: 2157 RQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2215
Query: 1607 QEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQ 1661
+E K A +E L+ L+ +R L ++ EE +L+ AQ
Sbjct: 2216 EELSKLKARIEAENRALI----LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2266
Score = 43.1 bits (100), Expect = 0.002
Identities = 204/1030 (19%), Positives = 381/1030 (36%), Gaps = 177/1030 (17%)
Query: 721 KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV 780
K H+ LE++ QL E + E +Q++ K Q+ L E ++ + DV
Sbjct: 350 KLHVAILEREKQLRSEFE-------RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR 402
Query: 781 NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840
L A G+ + E + +L + D + L +++ L++ Q E++ + +
Sbjct: 403 --LLAAGKVPQRAGEVERDLD-KADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERL 459
Query: 841 VLLRKELE---EIQSEKEALQSDLLEMKNANEKTRLEN------QNLLIQVEEVSQTCSK 891
V +R E + A Q + +++ + LE+ Q+LL VEE
Sbjct: 460 VAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG 519
Query: 892 SE--IHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKEL 949
+E + + + H L +E+ + RA D SP+ + + L
Sbjct: 520 AEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR----SDEGQLSPATRGAYRDCLGRL 575
Query: 950 EEKIENLEKECKEKEEKINKIKLVAVKAKKELD-SSRKETQTV----KEELESLRSEKDQ 1004
+ + L K + + + A KEL + KE + V + ++ ++K+
Sbjct: 576 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 635
Query: 1005 LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1064
SA MR+L E + + E + ++L E A + + + LQ
Sbjct: 636 YSALMREL----ELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQ---- 687
Query: 1065 NSDNEDLLARIET-LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123
L IE L+ NA + +V+ A+ + K EA L+++ + + TV
Sbjct: 688 ------LCCCIEAHLKENAAYFQF-FSDVREAEGQLQKLQEA--LRRKYSC-DRSATVTR 737
Query: 1124 LEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN--------------MEIADYERLM 1169
LE+L Q EK+QL + L + K A+ + + + DY+++
Sbjct: 738 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE 797
Query: 1170 KELNQ---------------KLTNKNNKIEDLEQEIKIQKQKQETLQEEITSL----QSS 1210
+++ K+ + + + + + QE +T L Q+
Sbjct: 798 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 857
Query: 1211 VQQYEEKNTKIKQLL----------------VKTKKELADSKQAETDH---LILQASLKG 1251
V + + + +K LL + T + L +Q + H L QA L+
Sbjct: 858 VTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRD 917
Query: 1252 ELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQ------EE 1305
+A E + E S H ++ L S EQ + S Q+ ++ L+ E
Sbjct: 918 SQDAGGFGPEDRLMAEREYGSCSHH-YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEA 976
Query: 1306 CRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKL 1365
C + + + E + + +QQK +QAE EG + L +++
Sbjct: 977 CETRTVHRLRLPLDKEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALP 1032
Query: 1366 QDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEH 1425
+ S TL+SE + L + L++ S A EKL +I
Sbjct: 1033 EPS--------PAAPTLRSELELTLGK----LEQVRSLSAIYLEKLKTI----------- 1069
Query: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485
+ + EVLR EE K + + L ++EA
Sbjct: 1070 SLVIRGTQGAEEVLR---------AHEEQLKEAQAVPATLPELEA--------------- 1105
Query: 1486 SSQQSLKNLRERRNTDLP----LLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541
++ SLK LR + P L D +E GE ++ E + + + QLL
Sbjct: 1106 -TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1164
Query: 1542 SPETKL-EPPLWHAEFTKEELVQKLSSTTKSADHLNGLL----RETEATNAILMEQIKLL 1596
+ L + + E E+L ++L +SAD L L R E A+ + + +
Sbjct: 1165 RWQAVLAQTDVRQREL--EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1222
Query: 1597 KSEIRRLER-NQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSP-EEKG 1654
+ ++R+ + +E E+ +E + Q+I + ++ L ++ QL P
Sbjct: 1223 REQLRQEQALLEEIERHGEKVEECQRFAKQYI----NAIKDYELQLVTYKAQLEPVASPA 1278
Query: 1655 KLAAVAQGEE 1664
K V G E
Sbjct: 1279 KKPKVQSGSE 1288
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 216 bits (551), Expect = 1e-55
Identities = 366/1752 (20%), Positives = 716/1752 (40%), Gaps = 197/1752 (11%)
Query: 11 SPATPGTGKSKLE-TLPKEDLIKFAK-------KQMMLIQKAKSRCTEL----EKEIEEL 58
SPA P T +S+LE TL K + ++ K + L+ + E+ E++++E
Sbjct: 1043 SPAAP-TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1101
Query: 59 RSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKM-GDAH 117
++ P T + KA ++L A +AE +Q ++ ++ QEV + + + G+
Sbjct: 1102 QAVPATLPELEATKASLKKLRA----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1157
Query: 118 KELEQSHINYV-----------------KEIENLKNELMAVRSKYSEDKANLQ---KQLE 157
E+E+ +E+E L +L R A LQ ++ E
Sbjct: 1158 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1217
Query: 158 EAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVT 217
+ L S+ ++ Q E + L EEIE+ EE + ++ ++A D + + VT
Sbjct: 1218 QIQAMPLADSQAVREQLRQE---QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1274
Query: 218 QLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELK 277
+ S + + S E ++Q + EL K + ++ E +
Sbjct: 1275 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-E 1333
Query: 278 ENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHL 337
E L +Q A E+ + E LE R+ A Q + +E ++Q + E+V
Sbjct: 1334 ERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAEREAKELQQRMQEEVVRR 1390
Query: 338 EDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQ 397
E+ + + Q +++E + L+ E + Q K E +I E + Q
Sbjct: 1391 EEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQ-AKARQAEAAERSRLRIEEEIRVVRLQ 1446
Query: 398 GCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF 457
+E + + G + + E ++ K Q Q+E L +S++++ +
Sbjct: 1447 ---LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1502
Query: 458 EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFE-SMKQQQASDV 516
+K + E +EKQ A+ E LR E + L ++ + +++ + +++ Q S
Sbjct: 1503 LASRVKAEAE-AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561
Query: 517 HELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLS 576
ELQ K R +F EK A LE L + V +L + ++ +
Sbjct: 1562 AELQSK-RASFAEKTAQLE---------RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1611
Query: 577 QRDTMLKELEGKINS---LTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQ 633
+ + L+ + K N L + ++ + + E + ++ ERE R GK EQ
Sbjct: 1612 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR---RRGKAEEQ 1668
Query: 634 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV-------QMKVLSEDKEVLSAE 686
++ EQ++ + E T +++ +Q+L +L Q ++L E+ L E
Sbjct: 1669 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1728
Query: 687 VKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLE 746
+ ++ +L +E ++ ++EV L+ K + T EK Q + E +L E
Sbjct: 1729 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS-EKSKQRLEAEAGRFRELAE 1787
Query: 747 NE-QVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRD 805
+++ L + + L E + E+ + L A+GE+ E + L
Sbjct: 1788 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---- 1843
Query: 806 EKVLELEKEIKCLQEESVVQCEELKSLLR----DYEQEKVLLRKELEEIQSEKEALQSDL 861
EK E E+ ++ L E+ Q L+ D E+ LRK + ++ L D
Sbjct: 1844 EKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1902
Query: 862 LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIH--------NEKEKCFIKEHENL---- 909
L ++ ++E + L ++ K+E+ N ++ KE L
Sbjct: 1903 LR-----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1957
Query: 910 -KPLLEQKELRDRRAELILLKDSLAKSPSVKNDP--LSSVKELEEKIENLEK-ECKEKEE 965
+ L ++E R R AE + K A+ + + L V+ L+ K+E + + ++E
Sbjct: 1958 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2017
Query: 966 KINKIKLVAVKAKKELDSSRK--------ETQTVKEELESLRSEKDQLSASMRDLIQGAE 1017
+++L A+K L + K + Q +++ L+ +S DQL + AE
Sbjct: 2018 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2077
Query: 1018 SYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIET 1077
+ ++ E+++ Q + E A + E+ + + E + + E AR
Sbjct: 2078 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2137
Query: 1078 LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQ 1137
+ A R K D E+E K EQ +++ A EL L++QL++ Q
Sbjct: 2138 AEQAAL----------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2187
Query: 1138 LQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQ 1197
+EL+ +K +A + ++ + ++ ++L+ +IE E I + K
Sbjct: 2188 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE-AENRALILRDKD 2246
Query: 1198 ET---LQEEITSLQSSVQQYE------EKNTKIKQLL---VKTKKELADSKQAETDHLIL 1245
T LQEE ++ ++ ++ +++QL + ++ LA+ E +
Sbjct: 2247 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2306
Query: 1246 QAS-LKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQE 1304
+A+ LK E E QQQ E+ + Q + +K ++ + L + QRTL A +QR
Sbjct: 2307 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR------ 2360
Query: 1305 ECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL-KI 1363
Q +++E E K+RV + +++ ++AE E A++ R+ E + ++L +
Sbjct: 2361 --------QLEMSAEAERLKLRV-----AEMSRAQARAE-EDAQRFRKQAEEIGEKLHRT 2406
Query: 1364 KLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS 1423
+L + + E+Q QS+HD + L+E +++ +EKL +++ + +KS
Sbjct: 2407 ELATQEKVTLVQTLEIQRQQSDHDA------ERLREAIAELEREKEKL-QQEAKLLQLKS 2459
Query: 1424 EHTQTV--SQLTSQNEVLRNSFRDQ-------VRHLQEEHRKTVETLQQQLSKMEAQLFQ 1474
E QTV QL + + L+ SF + R +++E K + Q +++K + QL +
Sbjct: 2460 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ-QLRE 2518
Query: 1475 LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQ 1534
+ + Q+ + ++ E R + +EE + +E + + Q
Sbjct: 2519 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2578
Query: 1535 SLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAI------ 1588
L + L E + L H+E V + D L+G E E ++
Sbjct: 2579 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2638
Query: 1589 -----LMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVL-----LQFIFLKPGSERERL 1638
L E L E++RL + A E +++ L + + LK +E+ +
Sbjct: 2639 VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2698
Query: 1639 LPVINTMLQLSP 1650
+ L LSP
Sbjct: 2699 YAALQRQL-LSP 2709
Score = 145 bits (365), Expect = 4e-34
Identities = 355/1856 (19%), Positives = 712/1856 (38%), Gaps = 335/1856 (18%)
Query: 7 DGVASPATPGTGKSKLETLPKE--DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVT 64
+G SPAT G + L L + L+ +K ++ ++ S KE+ L K
Sbjct: 565 EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE 624
Query: 65 EGTGDI------IKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMG---- 114
E D + A E AL+ E L LK++ IK Q D + +
Sbjct: 625 EVGFDWSDRNTNMTAKKESYSALMRE--------LELKEKKIKELQNAGDRLLREDHPAR 676
Query: 115 ------------------------DAHKELEQSHINYVKEIENLKNELM----AVRSKYS 146
+AH + ++ + ++ + +L A+R KYS
Sbjct: 677 PTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 736
Query: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
D++ +LE+ + + EQL + K + + +++P + + L
Sbjct: 737 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLL 796
Query: 207 ATTDEKKETVT-----QLQNIIEANSQHYQKNINSLQEELLQ----LKAIHQEEVKELMC 257
A D K+ VT + Q + A H++ +S E + L +E +E +
Sbjct: 797 AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 856
Query: 258 QIEASAKEHEAEINKLNELKENL--VKQCEASEKNIQKKYECELENLRKATSNANQDNQI 315
++EA +H+A + ++L ++ + ++ +++Q L R Q +
Sbjct: 857 RLEA---QHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR-TLKPEEQRQAL 912
Query: 316 CSILLQENTFV-----------------EQVVNEKVKHLEDTLKELESQH---------- 348
S+ L F+ E+ H + L+ LE
Sbjct: 913 HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 972
Query: 349 SILKD--------EVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKIN------------ 388
S LKD E ++ L+L L+ + + E++ + ++
Sbjct: 973 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1032
Query: 389 -ELLLAKEEQGCVIEKLKSE-------------LAGLNKQFCYTVEQHNREVQSLKE--- 431
E +LA E L+SE L+ + + T+ R Q +E
Sbjct: 1033 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1092
Query: 432 QHQKEISE-------LNETFLSDSEKEKLTLMFEIQ------------GLKEQCENLQQE 472
H++++ E L E + + +KL E Q G +E E LQQ
Sbjct: 1093 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1152
Query: 473 KQEAILNYESLREIM--------------EILQTELGESAGKISQEFES----------- 507
E + E RE + ++ Q EL + ++ ES
Sbjct: 1153 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1212
Query: 508 ---MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNL 564
+Q QA + + Q +R ++ ALLE + R EK+ Q + N IK+
Sbjct: 1213 RRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1268
Query: 565 QEKNGVYLLSLS-------------------QRDTMLKELEGKINSLTEEKDDFINKLKN 605
+ + Y L Q L+ ++ +LT + FI++
Sbjct: 1269 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1328
Query: 606 SHEEMDNF--HKKCEREERL-----ILELGKKV--------EQTIQYNSELEQKVNELTG 650
EE + ++ E ERL LE +++ Q + EL+Q++ E
Sbjct: 1329 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388
Query: 651 GLEETLKEKDQNDQKLEKLMVQMKVLSE-DKEVLSAEVKSLYEENNKLSSEKKQLSRDLE 709
EE + Q + +++ + Q++ SE + + + + ++ ++ E + + LE
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1448
Query: 710 VFLSQK-----EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLK 764
Q+ E L+ + E + + EE + L + +++E +K + +L +K
Sbjct: 1449 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1508
Query: 765 EMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVV 824
+E ++ LQA+ E + E + L E+ +++ ++ Q +
Sbjct: 1509 ------AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1562
Query: 825 QCEELKSLLRDYEQEKVLLRKELEE-------IQSEKEALQSDLLEMKNANEKTRLENQ- 876
EL+S + ++ L + L+E ++ E E E + A E+ E +
Sbjct: 1563 ---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619
Query: 877 ---------NLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELIL 927
L +Q EEV+Q S ++ EK+K + + E++ +R R L
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----L 1675
Query: 928 LKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
+ L K + E+++ L E ++ E++ ++ + ++E ++ ++
Sbjct: 1676 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1735
Query: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
Q ++ EL +R+E + L AS + + S EK ++L+ E R
Sbjct: 1736 RQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEAEAGRFRELAEEA 1789
Query: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIETL--QSNAKLLEVQILEVQRAKAMVDKELEA 1105
L + Q + D A E + + A + E L+ + A+ +KE E
Sbjct: 1790 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1849
Query: 1106 EKLQK------------EQKIKEHATTVNE-LEELQ----VQLQKEKKQLQKTMQELELV 1148
E+L++ E++ +H + E L +L+ +L+++K ++ T+++ V
Sbjct: 1850 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1909
Query: 1149 KKD-AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ-EIKIQKQKQETLQEEITS 1206
+++ A L EL + +N + + EQ E++ +Q+Q +EE
Sbjct: 1910 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE--- 1966
Query: 1207 LQSSVQQYEEKNTKIKQLLVKTKKELADSKQA--ETDHLILQASLKGELEASQQQVEVYK 1264
++ E ++++ L ++ K A E + L + L +Q +
Sbjct: 1967 -----RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2021
Query: 1265 IQLAEITSEK-----HKIHEHLKTSAEQH-QRTLSAYQQRVTALQEECRAAK-----AEQ 1313
+QLA+ ++K K H EQ Q+TL Q + L+ E AA+ AE+
Sbjct: 2022 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2081
Query: 1314 ATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ 1373
A V +E E+ + R V + ++ K ++ + + Q + E L + + Q++ Q
Sbjct: 2082 ARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE---QEAARRAQ 2137
Query: 1374 INVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLT 1433
+ L+ Q+ D +E+H K ++T+ ++A++ ++L +++ + + +++H + +
Sbjct: 2138 AEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEETDHQKNLLDEE 2194
Query: 1434 SQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKN 1493
Q + + R EE +V ++LSK++A++ E R+ +
Sbjct: 2195 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-----EAENRALI-------- 2241
Query: 1494 LRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWH 1553
LR++ NT L +EE E M+ E + S Q +L E L
Sbjct: 2242 LRDKDNTQRFL-------QEEAEKMKQV-AEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2293
Query: 1554 AEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQER 1609
AE +E +Q + T+ +A +L +Q +L + + RRL+ ++E+
Sbjct: 2294 AEKMLKEKMQAVQEATR-----------LKAEAELLQQQKELAQEQARRLQEDKEQ 2338
Score = 133 bits (335), Expect = 1e-30
Identities = 333/1795 (18%), Positives = 703/1795 (39%), Gaps = 298/1795 (16%)
Query: 109 SVTKMGDAHKELEQSHINYVKEIENLKNE----LMAVRSKYSEDKANLQKQLEEAMNTQL 164
SV +H+ L QS + +IE +++ A R Y + L Q + +N+
Sbjct: 536 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSS- 594
Query: 165 ELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIE 224
+L+ + V +E+ + EE++ + + KKE+ + L +E
Sbjct: 595 --KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 652
Query: 225 ANSQHYQKNINSLQEELLQ-----------LKAIHQEE---VKELMCQIEASAKEHEAEI 270
+ K + + + LL+ +A Q + + +L C IEA KE+ A
Sbjct: 653 LKEKKI-KELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 711
Query: 271 NKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVV 330
++++E Q + ++ +++KY C+ R AT +D LLQ+ ++ +
Sbjct: 712 QFFSDVRE-AEGQLQKLQEALRRKYSCD----RSATVTRLED------LLQDAQDEKEQL 760
Query: 331 NEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINEL 390
NE HL K ++ + + +L L + + E + D + +
Sbjct: 761 NEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGD---ECQLV 817
Query: 391 LLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQS----LKEQHQKEISELNETFLS 446
A+ V+ SE A C+ V N+E Q L+ QHQ ++ ++ +
Sbjct: 818 GPAQPSHWKVLSSSGSEAA--VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 875
Query: 447 -DSEKEKLTLMFEIQGLKE---------QCENLQQEKQEAILNYES-LREIME------- 488
S +L ++Q ++ + E +Q L+Y++ LR+ +
Sbjct: 876 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 935
Query: 489 ---ILQTELGESAGKISQEFESMK---------QQQASDVHELQQKLRTAFT-------- 528
+ + E G + Q +S++ Q+ S++ +++ +L T
Sbjct: 936 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 995
Query: 529 --EKDALLETVNRL--------------------QGENEKLLSQQELVP-------ELEN 559
+K+ E R+ E EK+L+ E P ELE
Sbjct: 996 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1055
Query: 560 TIKNLQE---KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDF----------------- 599
T+ L++ + +YL L +++ +G L ++
Sbjct: 1056 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1115
Query: 600 --INKLKNSHEEMDNFHKKCEREERLILELGKKVEQTI-QYNSELE---QKVNELTGGLE 653
+ KL+ E E R E+G++++Q + + E+E ++V +L +
Sbjct: 1116 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1175
Query: 654 ETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLS 713
L + D ++LE+L Q++ E + L A ++ ++ + S+ + L
Sbjct: 1176 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1235
Query: 714 QKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGF---LKEMGSEV 770
Q++ L E I + +K++ +++ ++Q + K QL K+ +
Sbjct: 1236 QEQ--ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1293
Query: 771 SEDSEEKDVVNV--------------LQAVGESLAKINEEKCNLAFQRDEK--------- 807
+S ++ V++ ++ + E+L ++ EE+ QR E+
Sbjct: 1294 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1353
Query: 808 VLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE-EIQSEKEALQSDLLEMKN 866
LE ++++ ++ Q E L+ QE+V+ R+E + Q +K ++Q +L +++
Sbjct: 1354 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1413
Query: 867 ANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRR---- 922
++E ++ +K+ E+ ++ E ++ + Q E +R+
Sbjct: 1414 SSE----------------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1457
Query: 923 -AELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKL-VAVKAKKE 980
EL L+ ++ + K ++ +E+ E L ++ +++ ++ + ++ +A + K E
Sbjct: 1458 EGELQALRARAEEAEAQK-------RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1510
Query: 981 LDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERA 1040
+++R E Q + LE LR + ++ +R + LE ++S + +++ +RA
Sbjct: 1511 AEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1569
Query: 1041 NNFEHRIEDLTRQLRNSTL-----------------QCETINSDNEDLLARIETLQSNAK 1083
+F + L R L+ + + E + E L R + + A
Sbjct: 1570 -SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1628
Query: 1084 LLEVQILEVQRAKAMVDKELEAEKLQKEQ------KIKEHATTVNELEELQVQLQK---E 1134
L +Q EV + K++ E E +K + E+ K +E A EL E +++ Q+ E
Sbjct: 1629 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1688
Query: 1135 KKQLQKTMQELELVKKDA------QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ 1188
Q+ E EL++ A QQ L+ E+A +R QK ++ +
Sbjct: 1689 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1748
Query: 1189 EIKIQKQKQETLQEEITSL-QSSVQQYEEKNTKIKQLL------------VKTKKELAD- 1234
E+++ + +EE S + S Q+ E + + ++L K +++LA+
Sbjct: 1749 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1808
Query: 1235 --SKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTL 1292
++Q +L L EA++ + E +I L E +E ++ + A Q +R
Sbjct: 1809 DAARQRAEAERVLAEKLAAIGEATRLKTEA-EIALKEKEAENERLRRLAEDEAFQRRRLE 1867
Query: 1293 SAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMS----QAETEGAK 1348
Q ++E R A+ +A+ SE E K V + L+Q++ +A E A
Sbjct: 1868 EQAAQHKADIEE--RLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1924
Query: 1349 QEREHLEMLIDQLKIKLQD---SQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA 1405
+ LE+ + +++ +D S+ ++ + + L +E + + +Q++++ E
Sbjct: 1925 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1984
Query: 1406 E-LREKLCSIQS-ENMMMKSEHTQTVSQLTSQNEVLRNSFRDQV--RHLQEEHR------ 1455
E R++ +++ E + K E + + + Q + + + LQ E +
Sbjct: 1985 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2044
Query: 1456 -KTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ-------------QSLKNLRERRNTD 1501
+ + LQQ L + ++ L QL+ E + + QS + + E
Sbjct: 2045 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2104
Query: 1502 LPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEEL 1561
+ + E E+ A+ Q+ + L + H +F ++ L
Sbjct: 2105 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164
Query: 1562 VQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERN--------------- 1606
QK + + L L ET+ +L E+++ LK+E R
Sbjct: 2165 RQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2223
Query: 1607 QEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQ 1661
+E K A +E L+ L+ +R L ++ EE +L+ AQ
Sbjct: 2224 EELSKLKARIEAENRALI----LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2274
Score = 43.1 bits (100), Expect = 0.002
Identities = 204/1030 (19%), Positives = 381/1030 (36%), Gaps = 177/1030 (17%)
Query: 721 KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV 780
K H+ LE++ QL E + E +Q++ K Q+ L E ++ + DV
Sbjct: 358 KLHVAILEREKQLRSEFE-------RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR 410
Query: 781 NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840
L A G+ + E + +L + D + L +++ L++ Q E++ + +
Sbjct: 411 --LLAAGKVPQRAGEVERDLD-KADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERL 467
Query: 841 VLLRKELE---EIQSEKEALQSDLLEMKNANEKTRLEN------QNLLIQVEEVSQTCSK 891
V +R E + A Q + +++ + LE+ Q+LL VEE
Sbjct: 468 VAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG 527
Query: 892 SE--IHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKEL 949
+E + + + H L +E+ + RA D SP+ + + L
Sbjct: 528 AEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR----SDEGQLSPATRGAYRDCLGRL 583
Query: 950 EEKIENLEKECKEKEEKINKIKLVAVKAKKELD-SSRKETQTV----KEELESLRSEKDQ 1004
+ + L K + + + A KEL + KE + V + ++ ++K+
Sbjct: 584 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 643
Query: 1005 LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1064
SA MR+L E + + E + ++L E A + + + LQ
Sbjct: 644 YSALMREL----ELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQ---- 695
Query: 1065 NSDNEDLLARIET-LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123
L IE L+ NA + +V+ A+ + K EA L+++ + + TV
Sbjct: 696 ------LCCCIEAHLKENAAYFQF-FSDVREAEGQLQKLQEA--LRRKYSC-DRSATVTR 745
Query: 1124 LEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN--------------MEIADYERLM 1169
LE+L Q EK+QL + L + K A+ + + + DY+++
Sbjct: 746 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE 805
Query: 1170 KELNQ---------------KLTNKNNKIEDLEQEIKIQKQKQETLQEEITSL----QSS 1210
+++ K+ + + + + + QE +T L Q+
Sbjct: 806 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 865
Query: 1211 VQQYEEKNTKIKQLL----------------VKTKKELADSKQAETDH---LILQASLKG 1251
V + + + +K LL + T + L +Q + H L QA L+
Sbjct: 866 VTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRD 925
Query: 1252 ELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQ------EE 1305
+A E + E S H ++ L S EQ + S Q+ ++ L+ E
Sbjct: 926 SQDAGGFGPEDRLMAEREYGSCSHH-YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEA 984
Query: 1306 CRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKL 1365
C + + + E + + +QQK +QAE EG + L +++
Sbjct: 985 CETRTVHRLRLPLDKEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALP 1040
Query: 1366 QDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEH 1425
+ S TL+SE + L + L++ S A EKL +I
Sbjct: 1041 EPS--------PAAPTLRSELELTLGK----LEQVRSLSAIYLEKLKTI----------- 1077
Query: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485
+ + EVLR EE K + + L ++EA
Sbjct: 1078 SLVIRGTQGAEEVLR---------AHEEQLKEAQAVPATLPELEA--------------- 1113
Query: 1486 SSQQSLKNLRERRNTDLP----LLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541
++ SLK LR + P L D +E GE ++ E + + + QLL
Sbjct: 1114 -TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1172
Query: 1542 SPETKL-EPPLWHAEFTKEELVQKLSSTTKSADHLNGLL----RETEATNAILMEQIKLL 1596
+ L + + E E+L ++L +SAD L L R E A+ + + +
Sbjct: 1173 RWQAVLAQTDVRQREL--EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1230
Query: 1597 KSEIRRLER-NQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSP-EEKG 1654
+ ++R+ + +E E+ +E + Q+I + ++ L ++ QL P
Sbjct: 1231 REQLRQEQALLEEIERHGEKVEECQRFAKQYI----NAIKDYELQLVTYKAQLEPVASPA 1286
Query: 1655 KLAAVAQGEE 1664
K V G E
Sbjct: 1287 KKPKVQSGSE 1296
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 216 bits (551), Expect = 1e-55
Identities = 366/1752 (20%), Positives = 716/1752 (40%), Gaps = 197/1752 (11%)
Query: 11 SPATPGTGKSKLE-TLPKEDLIKFAK-------KQMMLIQKAKSRCTEL----EKEIEEL 58
SPA P T +S+LE TL K + ++ K + L+ + E+ E++++E
Sbjct: 1084 SPAAP-TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1142
Query: 59 RSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKM-GDAH 117
++ P T + KA ++L A +AE +Q ++ ++ QEV + + + G+
Sbjct: 1143 QAVPATLPELEATKASLKKLRA----QAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1198
Query: 118 KELEQSHINYV-----------------KEIENLKNELMAVRSKYSEDKANLQ---KQLE 157
E+E+ +E+E L +L R A LQ ++ E
Sbjct: 1199 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1258
Query: 158 EAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVT 217
+ L S+ ++ Q E + L EEIE+ EE + ++ ++A D + + VT
Sbjct: 1259 QIQAMPLADSQAVREQLRQE---QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1315
Query: 218 QLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELK 277
+ S + + S E ++Q + EL K + ++ E +
Sbjct: 1316 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-E 1374
Query: 278 ENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHL 337
E L +Q A E+ + E LE R+ A Q + +E ++Q + E+V
Sbjct: 1375 ERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAEREAKELQQRMQEEVVRR 1431
Query: 338 EDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQ 397
E+ + + Q +++E + L+ E + Q K E +I E + Q
Sbjct: 1432 EEAAVDAQQQKRSIQEE---LQQLRQSSEAEIQ-AKARQAEAAERSRLRIEEEIRVVRLQ 1487
Query: 398 GCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF 457
+E + + G + + E ++ K Q Q+E L +S++++ +
Sbjct: 1488 ---LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1543
Query: 458 EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFE-SMKQQQASDV 516
+K + E +EKQ A+ E LR E + L ++ + +++ + +++ Q S
Sbjct: 1544 LASRVKAEAE-AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602
Query: 517 HELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLS 576
ELQ K R +F EK A LE L + V +L + ++ +
Sbjct: 1603 AELQSK-RASFAEKTAQLE---------RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1652
Query: 577 QRDTMLKELEGKINS---LTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQ 633
+ + L+ + K N L + ++ + + E + ++ ERE R GK EQ
Sbjct: 1653 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR---RRGKAEEQ 1709
Query: 634 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV-------QMKVLSEDKEVLSAE 686
++ EQ++ + E T +++ +Q+L +L Q ++L E+ L E
Sbjct: 1710 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1769
Query: 687 VKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLE 746
+ ++ +L +E ++ ++EV L+ K + T EK Q + E +L E
Sbjct: 1770 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS-EKSKQRLEAEAGRFRELAE 1828
Query: 747 NE-QVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRD 805
+++ L + + L E + E+ + L A+GE+ E + L
Sbjct: 1829 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---- 1884
Query: 806 EKVLELEKEIKCLQEESVVQCEELKSLLR----DYEQEKVLLRKELEEIQSEKEALQSDL 861
EK E E+ ++ L E+ Q L+ D E+ LRK + ++ L D
Sbjct: 1885 EKEAENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1943
Query: 862 LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIH--------NEKEKCFIKEHENL---- 909
L ++ ++E + L ++ K+E+ N ++ KE L
Sbjct: 1944 LR-----QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1998
Query: 910 -KPLLEQKELRDRRAELILLKDSLAKSPSVKNDP--LSSVKELEEKIENLEK-ECKEKEE 965
+ L ++E R R AE + K A+ + + L V+ L+ K+E + + ++E
Sbjct: 1999 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2058
Query: 966 KINKIKLVAVKAKKELDSSRK--------ETQTVKEELESLRSEKDQLSASMRDLIQGAE 1017
+++L A+K L + K + Q +++ L+ +S DQL + AE
Sbjct: 2059 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2118
Query: 1018 SYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIET 1077
+ ++ E+++ Q + E A + E+ + + E + + E AR
Sbjct: 2119 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2178
Query: 1078 LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQ 1137
+ A R K D E+E K EQ +++ A EL L++QL++ Q
Sbjct: 2179 AEQAAL----------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2228
Query: 1138 LQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQ 1197
+EL+ +K +A + ++ + ++ ++L+ +IE E I + K
Sbjct: 2229 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE-AENRALILRDKD 2287
Query: 1198 ET---LQEEITSLQSSVQQYE------EKNTKIKQLL---VKTKKELADSKQAETDHLIL 1245
T LQEE ++ ++ ++ +++QL + ++ LA+ E +
Sbjct: 2288 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2347
Query: 1246 QAS-LKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQE 1304
+A+ LK E E QQQ E+ + Q + +K ++ + L + QRTL A +QR
Sbjct: 2348 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR------ 2401
Query: 1305 ECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL-KI 1363
Q +++E E K+RV + +++ ++AE E A++ R+ E + ++L +
Sbjct: 2402 --------QLEMSAEAERLKLRV-----AEMSRAQARAE-EDAQRFRKQAEEIGEKLHRT 2447
Query: 1364 KLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS 1423
+L + + E+Q QS+HD + L+E +++ +EKL +++ + +KS
Sbjct: 2448 ELATQEKVTLVQTLEIQRQQSDHDA------ERLREAIAELEREKEKL-QQEAKLLQLKS 2500
Query: 1424 EHTQTV--SQLTSQNEVLRNSFRDQ-------VRHLQEEHRKTVETLQQQLSKMEAQLFQ 1474
E QTV QL + + L+ SF + R +++E K + Q +++K + QL +
Sbjct: 2501 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ-QLRE 2559
Query: 1475 LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQ 1534
+ + Q+ + ++ E R + +EE + +E + + Q
Sbjct: 2560 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2619
Query: 1535 SLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAI------ 1588
L + L E + L H+E V + D L+G E E ++
Sbjct: 2620 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2679
Query: 1589 -----LMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVL-----LQFIFLKPGSERERL 1638
L E L E++RL + A E +++ L + + LK +E+ +
Sbjct: 2680 VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSV 2739
Query: 1639 LPVINTMLQLSP 1650
+ L LSP
Sbjct: 2740 YAALQRQL-LSP 2750
Score = 145 bits (365), Expect = 4e-34
Identities = 355/1856 (19%), Positives = 712/1856 (38%), Gaps = 335/1856 (18%)
Query: 7 DGVASPATPGTGKSKLETLPKE--DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVT 64
+G SPAT G + L L + L+ +K ++ ++ S KE+ L K
Sbjct: 606 EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE 665
Query: 65 EGTGDI------IKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMG---- 114
E D + A E AL+ E L LK++ IK Q D + +
Sbjct: 666 EVGFDWSDRNTNMTAKKESYSALMRE--------LELKEKKIKELQNAGDRLLREDHPAR 717
Query: 115 ------------------------DAHKELEQSHINYVKEIENLKNELM----AVRSKYS 146
+AH + ++ + ++ + +L A+R KYS
Sbjct: 718 PTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYS 777
Query: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
D++ +LE+ + + EQL + K + + +++P + + L
Sbjct: 778 CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLL 837
Query: 207 ATTDEKKETVT-----QLQNIIEANSQHYQKNINSLQEELLQ----LKAIHQEEVKELMC 257
A D K+ VT + Q + A H++ +S E + L +E +E +
Sbjct: 838 AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVT 897
Query: 258 QIEASAKEHEAEINKLNELKENL--VKQCEASEKNIQKKYECELENLRKATSNANQDNQI 315
++EA +H+A + ++L ++ + ++ +++Q L R Q +
Sbjct: 898 RLEA---QHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR-TLKPEEQRQAL 953
Query: 316 CSILLQENTFV-----------------EQVVNEKVKHLEDTLKELESQH---------- 348
S+ L F+ E+ H + L+ LE
Sbjct: 954 HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 1013
Query: 349 SILKD--------EVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKIN------------ 388
S LKD E ++ L+L L+ + + E++ + ++
Sbjct: 1014 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1073
Query: 389 -ELLLAKEEQGCVIEKLKSE-------------LAGLNKQFCYTVEQHNREVQSLKE--- 431
E +LA E L+SE L+ + + T+ R Q +E
Sbjct: 1074 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1133
Query: 432 QHQKEISE-------LNETFLSDSEKEKLTLMFEIQ------------GLKEQCENLQQE 472
H++++ E L E + + +KL E Q G +E E LQQ
Sbjct: 1134 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1193
Query: 473 KQEAILNYESLREIM--------------EILQTELGESAGKISQEFES----------- 507
E + E RE + ++ Q EL + ++ ES
Sbjct: 1194 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1253
Query: 508 ---MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNL 564
+Q QA + + Q +R ++ ALLE + R EK+ Q + N IK+
Sbjct: 1254 RRRQEQIQAMPLAD-SQAVREQLRQEQALLEEIER---HGEKVEECQRFAKQYINAIKDY 1309
Query: 565 QEKNGVYLLSLS-------------------QRDTMLKELEGKINSLTEEKDDFINKLKN 605
+ + Y L Q L+ ++ +LT + FI++
Sbjct: 1310 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1369
Query: 606 SHEEMDNF--HKKCEREERL-----ILELGKKV--------EQTIQYNSELEQKVNELTG 650
EE + ++ E ERL LE +++ Q + EL+Q++ E
Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429
Query: 651 GLEETLKEKDQNDQKLEKLMVQMKVLSE-DKEVLSAEVKSLYEENNKLSSEKKQLSRDLE 709
EE + Q + +++ + Q++ SE + + + + ++ ++ E + + LE
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1489
Query: 710 VFLSQK-----EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLK 764
Q+ E L+ + E + + EE + L + +++E +K + +L +K
Sbjct: 1490 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1549
Query: 765 EMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVV 824
+E ++ LQA+ E + E + L E+ +++ ++ Q +
Sbjct: 1550 ------AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1603
Query: 825 QCEELKSLLRDYEQEKVLLRKELEE-------IQSEKEALQSDLLEMKNANEKTRLENQ- 876
EL+S + ++ L + L+E ++ E E E + A E+ E +
Sbjct: 1604 ---ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1660
Query: 877 ---------NLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELIL 927
L +Q EEV+Q S ++ EK+K + + E++ +R R L
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----L 1716
Query: 928 LKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
+ L K + E+++ L E ++ E++ ++ + ++E ++ ++
Sbjct: 1717 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776
Query: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
Q ++ EL +R+E + L AS + + S EK ++L+ E R
Sbjct: 1777 RQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEAEAGRFRELAEEA 1830
Query: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIETL--QSNAKLLEVQILEVQRAKAMVDKELEA 1105
L + Q + D A E + + A + E L+ + A+ +KE E
Sbjct: 1831 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1890
Query: 1106 EKLQK------------EQKIKEHATTVNE-LEELQ----VQLQKEKKQLQKTMQELELV 1148
E+L++ E++ +H + E L +L+ +L+++K ++ T+++ V
Sbjct: 1891 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1950
Query: 1149 KKD-AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ-EIKIQKQKQETLQEEITS 1206
+++ A L EL + +N + + EQ E++ +Q+Q +EE
Sbjct: 1951 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE--- 2007
Query: 1207 LQSSVQQYEEKNTKIKQLLVKTKKELADSKQA--ETDHLILQASLKGELEASQQQVEVYK 1264
++ E ++++ L ++ K A E + L + L +Q +
Sbjct: 2008 -----RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2062
Query: 1265 IQLAEITSEK-----HKIHEHLKTSAEQH-QRTLSAYQQRVTALQEECRAAK-----AEQ 1313
+QLA+ ++K K H EQ Q+TL Q + L+ E AA+ AE+
Sbjct: 2063 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122
Query: 1314 ATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ 1373
A V +E E+ + R V + ++ K ++ + + Q + E L + + Q++ Q
Sbjct: 2123 ARVQAEREAAQSR-RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE---QEAARRAQ 2178
Query: 1374 INVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLT 1433
+ L+ Q+ D +E+H K ++T+ ++A++ ++L +++ + + +++H + +
Sbjct: 2179 AEQAALRQKQAA-DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEETDHQKNLLDEE 2235
Query: 1434 SQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKN 1493
Q + + R EE +V ++LSK++A++ E R+ +
Sbjct: 2236 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI-----EAENRALI-------- 2282
Query: 1494 LRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWH 1553
LR++ NT L +EE E M+ E + S Q +L E L
Sbjct: 2283 LRDKDNTQRFL-------QEEAEKMKQV-AEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2334
Query: 1554 AEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQER 1609
AE +E +Q + T+ +A +L +Q +L + + RRL+ ++E+
Sbjct: 2335 AEKMLKEKMQAVQEATR-----------LKAEAELLQQQKELAQEQARRLQEDKEQ 2379
Score = 133 bits (335), Expect = 1e-30
Identities = 333/1795 (18%), Positives = 703/1795 (39%), Gaps = 298/1795 (16%)
Query: 109 SVTKMGDAHKELEQSHINYVKEIENLKNE----LMAVRSKYSEDKANLQKQLEEAMNTQL 164
SV +H+ L QS + +IE +++ A R Y + L Q + +N+
Sbjct: 577 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSS- 635
Query: 165 ELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIE 224
+L+ + V +E+ + EE++ + + KKE+ + L +E
Sbjct: 636 --KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 693
Query: 225 ANSQHYQKNINSLQEELLQ-----------LKAIHQEE---VKELMCQIEASAKEHEAEI 270
+ K + + + LL+ +A Q + + +L C IEA KE+ A
Sbjct: 694 LKEKKI-KELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 752
Query: 271 NKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVV 330
++++E Q + ++ +++KY C+ R AT +D LLQ+ ++ +
Sbjct: 753 QFFSDVRE-AEGQLQKLQEALRRKYSCD----RSATVTRLED------LLQDAQDEKEQL 801
Query: 331 NEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINEL 390
NE HL K ++ + + +L L + + E + D + +
Sbjct: 802 NEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGD---ECQLV 858
Query: 391 LLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQS----LKEQHQKEISELNETFLS 446
A+ V+ SE A C+ V N+E Q L+ QHQ ++ ++ +
Sbjct: 859 GPAQPSHWKVLSSSGSEAA--VPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 916
Query: 447 -DSEKEKLTLMFEIQGLKE---------QCENLQQEKQEAILNYES-LREIME------- 488
S +L ++Q ++ + E +Q L+Y++ LR+ +
Sbjct: 917 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 976
Query: 489 ---ILQTELGESAGKISQEFESMK---------QQQASDVHELQQKLRTAFT-------- 528
+ + E G + Q +S++ Q+ S++ +++ +L T
Sbjct: 977 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1036
Query: 529 --EKDALLETVNRL--------------------QGENEKLLSQQELVP-------ELEN 559
+K+ E R+ E EK+L+ E P ELE
Sbjct: 1037 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1096
Query: 560 TIKNLQE---KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDF----------------- 599
T+ L++ + +YL L +++ +G L ++
Sbjct: 1097 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1156
Query: 600 --INKLKNSHEEMDNFHKKCEREERLILELGKKVEQTI-QYNSELE---QKVNELTGGLE 653
+ KL+ E E R E+G++++Q + + E+E ++V +L +
Sbjct: 1157 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1216
Query: 654 ETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLS 713
L + D ++LE+L Q++ E + L A ++ ++ + S+ + L
Sbjct: 1217 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1276
Query: 714 QKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGF---LKEMGSEV 770
Q++ L E I + +K++ +++ ++Q + K QL K+ +
Sbjct: 1277 QEQ--ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1334
Query: 771 SEDSEEKDVVNV--------------LQAVGESLAKINEEKCNLAFQRDEK--------- 807
+S ++ V++ ++ + E+L ++ EE+ QR E+
Sbjct: 1335 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1394
Query: 808 VLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE-EIQSEKEALQSDLLEMKN 866
LE ++++ ++ Q E L+ QE+V+ R+E + Q +K ++Q +L +++
Sbjct: 1395 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1454
Query: 867 ANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRR---- 922
++E ++ +K+ E+ ++ E ++ + Q E +R+
Sbjct: 1455 SSE----------------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1498
Query: 923 -AELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKL-VAVKAKKE 980
EL L+ ++ + K ++ +E+ E L ++ +++ ++ + ++ +A + K E
Sbjct: 1499 EGELQALRARAEEAEAQK-------RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1551
Query: 981 LDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERA 1040
+++R E Q + LE LR + ++ +R + LE ++S + +++ +RA
Sbjct: 1552 AEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1610
Query: 1041 NNFEHRIEDLTRQLRNSTL-----------------QCETINSDNEDLLARIETLQSNAK 1083
+F + L R L+ + + E + E L R + + A
Sbjct: 1611 -SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1669
Query: 1084 LLEVQILEVQRAKAMVDKELEAEKLQKEQ------KIKEHATTVNELEELQVQLQK---E 1134
L +Q EV + K++ E E +K + E+ K +E A EL E +++ Q+ E
Sbjct: 1670 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1729
Query: 1135 KKQLQKTMQELELVKKDA------QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ 1188
Q+ E EL++ A QQ L+ E+A +R QK ++ +
Sbjct: 1730 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1789
Query: 1189 EIKIQKQKQETLQEEITSL-QSSVQQYEEKNTKIKQLL------------VKTKKELAD- 1234
E+++ + +EE S + S Q+ E + + ++L K +++LA+
Sbjct: 1790 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1849
Query: 1235 --SKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTL 1292
++Q +L L EA++ + E +I L E +E ++ + A Q +R
Sbjct: 1850 DAARQRAEAERVLAEKLAAIGEATRLKTEA-EIALKEKEAENERLRRLAEDEAFQRRRLE 1908
Query: 1293 SAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMS----QAETEGAK 1348
Q ++E R A+ +A+ SE E K V + L+Q++ +A E A
Sbjct: 1909 EQAAQHKADIEE--RLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1965
Query: 1349 QEREHLEMLIDQLKIKLQD---SQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA 1405
+ LE+ + +++ +D S+ ++ + + L +E + + +Q++++ E
Sbjct: 1966 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2025
Query: 1406 E-LREKLCSIQS-ENMMMKSEHTQTVSQLTSQNEVLRNSFRDQV--RHLQEEHR------ 1455
E R++ +++ E + K E + + + Q + + + LQ E +
Sbjct: 2026 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2085
Query: 1456 -KTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ-------------QSLKNLRERRNTD 1501
+ + LQQ L + ++ L QL+ E + + QS + + E
Sbjct: 2086 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2145
Query: 1502 LPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEEL 1561
+ + E E+ A+ Q+ + L + H +F ++ L
Sbjct: 2146 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205
Query: 1562 VQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERN--------------- 1606
QK + + L L ET+ +L E+++ LK+E R
Sbjct: 2206 RQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2264
Query: 1607 QEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQ 1661
+E K A +E L+ L+ +R L ++ EE +L+ AQ
Sbjct: 2265 EELSKLKARIEAENRALI----LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2315
Score = 43.1 bits (100), Expect = 0.002
Identities = 204/1030 (19%), Positives = 381/1030 (36%), Gaps = 177/1030 (17%)
Query: 721 KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV 780
K H+ LE++ QL E + E +Q++ K Q+ L E ++ + DV
Sbjct: 399 KLHVAILEREKQLRSEFE-------RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVR 451
Query: 781 NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840
L A G+ + E + +L + D + L +++ L++ Q E++ + +
Sbjct: 452 --LLAAGKVPQRAGEVERDLD-KADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERL 508
Query: 841 VLLRKELE---EIQSEKEALQSDLLEMKNANEKTRLEN------QNLLIQVEEVSQTCSK 891
V +R E + A Q + +++ + LE+ Q+LL VEE
Sbjct: 509 VAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDG 568
Query: 892 SE--IHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKEL 949
+E + + + H L +E+ + RA D SP+ + + L
Sbjct: 569 AEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR----SDEGQLSPATRGAYRDCLGRL 624
Query: 950 EEKIENLEKECKEKEEKINKIKLVAVKAKKELD-SSRKETQTV----KEELESLRSEKDQ 1004
+ + L K + + + A KEL + KE + V + ++ ++K+
Sbjct: 625 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 684
Query: 1005 LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1064
SA MR+L E + + E + ++L E A + + + LQ
Sbjct: 685 YSALMREL----ELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQ---- 736
Query: 1065 NSDNEDLLARIET-LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123
L IE L+ NA + +V+ A+ + K EA L+++ + + TV
Sbjct: 737 ------LCCCIEAHLKENAAYFQF-FSDVREAEGQLQKLQEA--LRRKYSC-DRSATVTR 786
Query: 1124 LEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN--------------MEIADYERLM 1169
LE+L Q EK+QL + L + K A+ + + + DY+++
Sbjct: 787 LEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE 846
Query: 1170 KELNQ---------------KLTNKNNKIEDLEQEIKIQKQKQETLQEEITSL----QSS 1210
+++ K+ + + + + + QE +T L Q+
Sbjct: 847 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 906
Query: 1211 VQQYEEKNTKIKQLL----------------VKTKKELADSKQAETDH---LILQASLKG 1251
V + + + +K LL + T + L +Q + H L QA L+
Sbjct: 907 VTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRD 966
Query: 1252 ELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQ------EE 1305
+A E + E S H ++ L S EQ + S Q+ ++ L+ E
Sbjct: 967 SQDAGGFGPEDRLMAEREYGSCSHH-YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEA 1025
Query: 1306 CRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKL 1365
C + + + E + + +QQK +QAE EG + L +++
Sbjct: 1026 CETRTVHRLRLPLDKEPARECAQRIAEQQK----AQAEVEGLGKGVARLSAEAEKVLALP 1081
Query: 1366 QDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEH 1425
+ S TL+SE + L + L++ S A EKL +I
Sbjct: 1082 EPS--------PAAPTLRSELELTLGK----LEQVRSLSAIYLEKLKTI----------- 1118
Query: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485
+ + EVLR EE K + + L ++EA
Sbjct: 1119 SLVIRGTQGAEEVLR---------AHEEQLKEAQAVPATLPELEA--------------- 1154
Query: 1486 SSQQSLKNLRERRNTDLP----LLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541
++ SLK LR + P L D +E GE ++ E + + + QLL
Sbjct: 1155 -TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1213
Query: 1542 SPETKL-EPPLWHAEFTKEELVQKLSSTTKSADHLNGLL----RETEATNAILMEQIKLL 1596
+ L + + E E+L ++L +SAD L L R E A+ + + +
Sbjct: 1214 RWQAVLAQTDVRQREL--EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1271
Query: 1597 KSEIRRLER-NQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSP-EEKG 1654
+ ++R+ + +E E+ +E + Q+I + ++ L ++ QL P
Sbjct: 1272 REQLRQEQALLEEIERHGEKVEECQRFAKQYI----NAIKDYELQLVTYKAQLEPVASPA 1327
Query: 1655 KLAAVAQGEE 1664
K V G E
Sbjct: 1328 KKPKVQSGSE 1337
>gi|157266273 RANBP2-like and GRIP domain containing 1 [Homo sapiens]
Length = 1756
Score = 211 bits (536), Expect = 6e-54
Identities = 143/328 (43%), Positives = 196/328 (59%), Gaps = 35/328 (10%)
Query: 1361 LKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMM 1420
++ KLQD ++ + E +T Q E D+L+ H VS+ + RE C + ++
Sbjct: 1438 VRFKLQDVADSFKKIFDEAKTAQ-EKDSLITPH-------VSRSSTPRESPCGKIAVAVL 1489
Query: 1421 MKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTV----------ETLQQQLSKMEA 1470
E T+ + + ++V + +V E K V E++++ S ++
Sbjct: 1490 --EETTRERTDVIQGDDVADAASEVEVSSTSETTTKAVVSPPKFVFGSESVKRIFSSEKS 1547
Query: 1471 QLFQLKNEPTTRS--------PVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTD 1522
F N T S P+ S S + + ++ + + + +++D
Sbjct: 1548 NPFAFGNSSATGSLFGFSFNAPLKSNDSETSSVAQSGSESKVEPKKCELSKNSDIEQSSD 1607
Query: 1523 TESVSSASTYTQ---SLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLL 1579
++ + ++++ S+ +PE EPPLWHAEFTKEELVQKLSSTTKSAD LNGLL
Sbjct: 1608 SKVKNLSASFPMEESSINYTFKTPEK--EPPLWHAEFTKEELVQKLSSTTKSADQLNGLL 1665
Query: 1580 RETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLL 1639
RETEAT+A+LMEQIKLLKSEIRRLERNQ E+SAAN+E+LKNVLLQFIFLKPGSERE LL
Sbjct: 1666 RETEATSAVLMEQIKLLKSEIRRLERNQ--EESAANVEHLKNVLLQFIFLKPGSERESLL 1723
Query: 1640 PVINTMLQLSPEEKGKLAAVAQGEEENA 1667
PVINTMLQLSPEEKGKLAAVAQG +E +
Sbjct: 1724 PVINTMLQLSPEEKGKLAAVAQGLQETS 1751
Score = 32.0 bits (71), Expect = 5.2
Identities = 31/150 (20%), Positives = 69/150 (46%), Gaps = 19/150 (12%)
Query: 881 QVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKN 940
+ V+Q+ S+S++ E +KC + ++ +++ + K +L+ S ++
Sbjct: 1576 ETSSVAQSGSESKV--EPKKCELSKNSDIEQSSDSKV------------KNLSASFPMEE 1621
Query: 941 DPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVK----EELE 996
++ + EK L KEE + K+ K+ +L+ +ET+ E+++
Sbjct: 1622 SSINYTFKTPEKEPPLWHAEFTKEELVQKLSSTT-KSADQLNGLLRETEATSAVLMEQIK 1680
Query: 997 SLRSEKDQLSASMRDLIQGAESYKNLLLEY 1026
L+SE +L + + E KN+LL++
Sbjct: 1681 LLKSEIRRLERNQEESAANVEHLKNVLLQF 1710
Score = 31.6 bits (70), Expect = 6.8
Identities = 25/103 (24%), Positives = 43/103 (41%)
Query: 647 ELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSR 706
EL L T K DQ + L + VL E ++L +E++ L + ++ + L
Sbjct: 1646 ELVQKLSSTTKSADQLNGLLRETEATSAVLMEQIKLLKSEIRRLERNQEESAANVEHLKN 1705
Query: 707 DLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQ 749
L F+ K + + + LQL EE+ L + + Q
Sbjct: 1706 VLLQFIFLKPGSERESLLPVINTMLQLSPEEKGKLAAVAQGLQ 1748
>gi|118200331 RANBP2-like and GRIP domain containing 2 [Homo sapiens]
Length = 1013
Score = 211 bits (536), Expect = 6e-54
Identities = 143/328 (43%), Positives = 196/328 (59%), Gaps = 35/328 (10%)
Query: 1361 LKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMM 1420
++ KLQD ++ + E +T Q E D+L+ H VS+ + RE C + ++
Sbjct: 695 VRFKLQDVADSFKKIFDEAKTAQ-EKDSLITPH-------VSRSSTPRESPCGKIAVAVL 746
Query: 1421 MKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTV----------ETLQQQLSKMEA 1470
E T+ + + ++V + +V E K V E++++ S ++
Sbjct: 747 --EETTRERTDVIQGDDVADAASEVEVSSTSETTTKAVVSPPKFVFGSESVKRIFSSEKS 804
Query: 1471 QLFQLKNEPTTRS--------PVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTD 1522
F N T S P+ S S + + ++ + + + +++D
Sbjct: 805 NPFAFGNSSATGSLFGFSFNAPLKSNDSETSSVAQSGSESKVEPKKCELSKNSDIEQSSD 864
Query: 1523 TESVSSASTYTQ---SLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLL 1579
++ + ++++ S+ +PE EPPLWHAEFTKEELVQKLSSTTKSAD LNGLL
Sbjct: 865 SKVKNLSASFPMEESSINYTFKTPEK--EPPLWHAEFTKEELVQKLSSTTKSADQLNGLL 922
Query: 1580 RETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLL 1639
RETEAT+A+LMEQIKLLKSEIRRLERNQ E+SAAN+E+LKNVLLQFIFLKPGSERE LL
Sbjct: 923 RETEATSAVLMEQIKLLKSEIRRLERNQ--EESAANVEHLKNVLLQFIFLKPGSERESLL 980
Query: 1640 PVINTMLQLSPEEKGKLAAVAQGEEENA 1667
PVINTMLQLSPEEKGKLAAVAQG +E +
Sbjct: 981 PVINTMLQLSPEEKGKLAAVAQGLQETS 1008
Score = 32.0 bits (71), Expect = 5.2
Identities = 31/150 (20%), Positives = 69/150 (46%), Gaps = 19/150 (12%)
Query: 881 QVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKN 940
+ V+Q+ S+S++ E +KC + ++ +++ + K +L+ S ++
Sbjct: 833 ETSSVAQSGSESKV--EPKKCELSKNSDIEQSSDSKV------------KNLSASFPMEE 878
Query: 941 DPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVK----EELE 996
++ + EK L KEE + K+ K+ +L+ +ET+ E+++
Sbjct: 879 SSINYTFKTPEKEPPLWHAEFTKEELVQKLSSTT-KSADQLNGLLRETEATSAVLMEQIK 937
Query: 997 SLRSEKDQLSASMRDLIQGAESYKNLLLEY 1026
L+SE +L + + E KN+LL++
Sbjct: 938 LLKSEIRRLERNQEESAANVEHLKNVLLQF 967
Score = 31.6 bits (70), Expect = 6.8
Identities = 25/103 (24%), Positives = 43/103 (41%)
Query: 647 ELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSR 706
EL L T K DQ + L + VL E ++L +E++ L + ++ + L
Sbjct: 903 ELVQKLSSTTKSADQLNGLLRETEATSAVLMEQIKLLKSEIRRLERNQEESAANVEHLKN 962
Query: 707 DLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQ 749
L F+ K + + + LQL EE+ L + + Q
Sbjct: 963 VLLQFIFLKPGSERESLLPVINTMLQLSPEEKGKLAAVAQGLQ 1005
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 207 bits (527), Expect = 7e-53
Identities = 376/1790 (21%), Positives = 767/1790 (42%), Gaps = 268/1790 (14%)
Query: 27 KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKA 86
+ DL K K + ++ + +E+ E + + E + I AL L +
Sbjct: 387 RSDLDKAEKLKSLMASEVDDHHAAIERR-NEYNLRKLDEEYKERIAALKNEL------RK 439
Query: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146
E EQ K+ ++++QE+E + T+ L S +KE L+NEL+ K +
Sbjct: 440 EREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS----LKENSRLENELLENAEKLA 495
Query: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
E + NL +L+ N + L+E+ + S +E + ++R +E Q LQ Q+D
Sbjct: 496 EYE-NLTNKLQR--NLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD 552
Query: 207 ATTDEKKETVTQ-------LQNI----IEANSQHYQKNIN-----------SLQEELL-- 242
E +E Q L+N +EANS + S++ EL+
Sbjct: 553 ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 612
Query: 243 QLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENL 302
Q+K H ++ L ++E + +E ++ + V C+ +++N+++++E E L
Sbjct: 613 QMKEQHHRDICCLRLELEDKVRHYEKQL-------DETVVSCKKAQENMKQRHENETHTL 665
Query: 303 RKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLK---ELESQHSILKDEVTYMN 359
K S+ N+I + Q E +H E+ + +LE + + L++++ +
Sbjct: 666 EKQISDLK--NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQH 723
Query: 360 NLKLKLEMDAQHIKDEFFHEREDL------EFKINELL-----LAKEEQGCVIEKLKSEL 408
++LK + + F ERE L E K+ L +E+ ++EK E
Sbjct: 724 EMELKARL--TQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEK 781
Query: 409 AGLNKQFCYTVEQHNREVQSLKEQHQKE----ISELNETFLSDSEKEKLTLMFEIQGL-- 462
L K+ +E+H RE+Q +E+ + E S++ F SD +K +Q L
Sbjct: 782 EELRKEL---LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG 838
Query: 463 --KEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520
+++ ++LQ++++E +E ++ E+ Q E E+ + E++K+++ + + Q
Sbjct: 839 RYRQELKDLQEQQREEKSQWEFEKD--ELTQ-ECAEAQELLK---ETLKREKTTSLVLTQ 892
Query: 521 QK----------LRTAFTEKDALLETVNRLQGENE---KLLSQQELVPELENTIK-NLQE 566
++ L + E+ LL+ + L+ +E LLS Q L EL+++ K L+E
Sbjct: 893 EREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQIL--ELKSSHKRELRE 950
Query: 567 KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHK-KCEREERLIL 625
+ V + + + LE +E+ + ++KL M+N HK CE +R
Sbjct: 951 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLL----AMENIHKATCETADRERA 1006
Query: 626 ELGKKVEQTIQYNSELEQKVNELT---GGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEV 682
E+ ++ + E++Q + L+ G + +E+ + D L L ++L E+ +V
Sbjct: 1007 EMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDV 1066
Query: 683 LSAEVKS---LYEENNKLSSEKKQLSRDLE-----VFLSQKEDVILKEHITQLEKKLQLM 734
L + ++ +EN K+++E +L + L+ + +S D E ++ +
Sbjct: 1067 LLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPF 1126
Query: 735 VEEQDNLNKLLENEQVQKLFVKTQLY-GFLKEMGSEVSEDSEEKDV-VNVLQAVGESLAK 792
+++ N+ + E V + V + L ++++GS + + ++V + +A E ++
Sbjct: 1127 LQQ----NRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSE 1182
Query: 793 INEEKCNLAFQRDEKVLELEKEIKCLQEESVV---QCEELKSLLRDYEQEKVLLRKEL-- 847
+ + + + EL+ +I LQE+ ++ C+ +D + +L+K+L
Sbjct: 1183 LENSE-----ETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKM 1237
Query: 848 ---------------EEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQV---------- 882
E++ E + LQ +L M+ ++ N+ L +V
Sbjct: 1238 LERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1297
Query: 883 EEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKN-- 940
EEV++T E ++ K E N+ L Q ++ + ++ D S++N
Sbjct: 1298 EEVTETFLSLEKSYDEVK-IENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLE 1356
Query: 941 -DPLSSVKELEEKIE----------NLEKECKEKEEKI--NKIKLVAVKA---------- 977
+P ++ +L + +E ++ +ECK++ + + N L VKA
Sbjct: 1357 IEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTI 1416
Query: 978 KKELDSSRKETQTVKEELESLRSEKD---QLSASMRDLIQGAESYKNLLLEYEKQSEQLD 1034
+ + R + Q + EE +L +D Q A++ +L + L + +++ L
Sbjct: 1417 QTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILV 1476
Query: 1035 VEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQR 1094
+K+ ++ E + E+L + + + C + E L E LQ +L +I +
Sbjct: 1477 KQKDVLSHGE-KEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1535
Query: 1095 AKAMVDKEL------EAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELV 1148
++ + +L + E QK + +K+ V ++ E L+K+ +L+ Q+L+L
Sbjct: 1536 EDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVE---NLKKQISELKIKNQQLDLE 1592
Query: 1149 KKDAQQTTLMNMEIADYERLMKELNQKLTNK---------NNKIEDLEQEIKIQKQKQET 1199
+ Q N E ++ELNQ+LT N+ +E+ EQE K++ E
Sbjct: 1593 NTELSQKNSQNQE------KLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELER 1646
Query: 1200 LQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQ 1259
+ + ++L SS++ E KI+ +V+ + L + + + Q +L QQ+
Sbjct: 1647 CKVQSSTLVSSLEA-ELSEVKIQTHIVQQENHLLKDELEK----MKQLHRCPDLSDFQQK 1701
Query: 1260 VEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSE 1319
+ ++ EK + E L + ++ ++ S + R+ +++E ++ + + A++ S+
Sbjct: 1702 ISSVLSYNEKLLKEKEALSEELNSCVDKLAKS-SLLEHRIATMKQEQKSWEHQSASLKSQ 1760
Query: 1320 FESYKVRVHNV--LKQQKNKSMSQAETE--GAKQEREHLEMLIDQLKIKLQDS------- 1368
+ + +V N+ Q N MS+ +++ +QE+E L+ + L +LQ++
Sbjct: 1761 LVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAP 1820
Query: 1369 ----------QNNLQINVSELQTLQSEHDTLLERHNKMLQETV-SKEAEL---REKLCSI 1414
+++ +L L +E LL + N+ LQ V + +AEL REK+ +
Sbjct: 1821 EIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQL 1880
Query: 1415 QSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLS-KMEAQLF 1473
+S N++ K + S + E + S + + Q+E + Q S + E +
Sbjct: 1881 ES-NLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETI 1939
Query: 1474 QLKNEPTTRSPVSSQQSLKNLRERRNT----------DLPLLDMHT---VTREEGEGMET 1520
L+NE + V + L ++ R+T DL LL V RE+ ++
Sbjct: 1940 HLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQ- 1998
Query: 1521 TDTESVSSASTYTQSLEQLL-------NSPETKLEPPLWHAEFTKEELVQKLSSTTKSAD 1573
+ A Q L++ L N+P+ E + E E+ QKL +
Sbjct: 1999 ---RQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQ 2055
Query: 1574 HLNGLLRETEATNAILMEQIKLLKSE----IRRLERNQEREKSAANLEYL 1619
L+E N +K L E ++ LE ++R+K+A YL
Sbjct: 2056 EKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYL 2105
Score = 132 bits (332), Expect = 3e-30
Identities = 287/1419 (20%), Positives = 602/1419 (42%), Gaps = 294/1419 (20%)
Query: 28 EDLIKFAKKQMM-LIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKA 86
++L +F ++Q+ L++K EL KE+ E + + EG EK
Sbjct: 760 QELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGR----------------EKM 803
Query: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGD-AHKELEQSHINYVKEIENLKNELMAVRSKY 145
ETE + +++ + + K+ + L+ Y +E+++L+ + +S++
Sbjct: 804 ETE-----CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQW 858
Query: 146 SEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQL 205
+K L ++ EA L E LK + + + + +E +EK ++ L
Sbjct: 859 EFEKDELTQECAEAQEL---LKETLKREKTTSLVLTQEREMLEKT----------YKEHL 905
Query: 206 DATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKE---LMCQIEAS 262
++ E+++ + L+++ N Q+++ L +++L+LK+ H+ E++E ++CQ AS
Sbjct: 906 NSMVVERQQLLQDLEDL--RNVSETQQSL--LSDQILELKSSHKRELREREEVLCQAGAS 961
Query: 263 AK-----------EHEAE----INKLNELKENLVKQCEASEKNIQK------KYECELEN 301
+ EH+ E ++KL ++ CE +++ + + + +++
Sbjct: 962 EQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKE 1021
Query: 302 LRKATSNANQDNQICSILLQENTFVEQVVN------EKVKHLEDTLKELESQHSILKDEV 355
+++ATS + C ++ +E + ++ + ++ D L L+ H E
Sbjct: 1022 MQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKEN 1081
Query: 356 TYMNNLKLKLEMDAQHIKD-------------EFFHEREDLEFKINELLLAKEEQGCVIE 402
M +L+ Q ++ EFF + + K+ +G
Sbjct: 1082 VKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRR 1141
Query: 403 KLKSELAGLNKQFCYTVEQHNREVQSLK-EQHQKEISELNETFLSDSEK-EKLTLMFEIQ 460
+ S+L + + + + Q +K E+ + + +E S+ + E L +I
Sbjct: 1142 HVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQIS 1201
Query: 461 GLKEQ-------CENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQA 513
L+EQ C+ ++KQ+ + + L++ +++L+ + E++ K +E + ++
Sbjct: 1202 QLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLE-RIPEASPKYKLLYEDVSREND 1260
Query: 514 SDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLL 573
LQ++LR T D LE L E +L + + + E+ T +L++ +
Sbjct: 1261 C----LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKI 1316
Query: 574 SLSQRDTMLKELEGKINSLTE--------------------EKDDFINKLKNSHEE---- 609
+ + ++ L+GKI L E E D I +L + EE
Sbjct: 1317 ENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPR 1376
Query: 610 ---MDNFHKKCEREERLI---LELGKKVEQ--------TIQYNSELEQKVNELTGGLEE- 654
+ + ++C++E + + +L +KV+ TIQ + E + N++ LEE
Sbjct: 1377 VRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVI--LEEN 1434
Query: 655 ---------------TLKEKDQNDQKLEKLMVQMK----VLSEDKEVLS-----AEVKSL 690
T+ E + KL++L ++K +L + K+VLS E+K++
Sbjct: 1435 TTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAM 1494
Query: 691 YEENNKLSSEKKQLSRDL--EVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENE 748
+ SE +Q L E Q+E+ IL+ IT L ++ + NL N
Sbjct: 1495 MHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE-----DSISNLKLGTLNG 1549
Query: 749 QVQKLFVKTQLYGFLKEMGSEVSEDSEE-KDVVNVLQAVGESLAKINEEKCNLAFQRDEK 807
++++ KT+ +K+ + V + E K ++ L+ + L N E Q EK
Sbjct: 1550 SQEEMWQKTET---VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEK 1606
Query: 808 VLELEK---EIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE--EIQSEK--EALQSD 860
+ EL + E+ C +E+ E S L + EQEK L++ELE ++QS +L+++
Sbjct: 1607 LQELNQRLTEMLCQKEK-----EPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAE 1661
Query: 861 LLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELR- 919
L E+K + EN L ++E++ Q ++ + ++K N K L E++ L
Sbjct: 1662 LSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSE 1721
Query: 920 ------DRRAELILLKDSLA-----------KSPSVKNDPLSS---VKELEEKIENLEKE 959
D+ A+ LL+ +A +S S+K+ ++S V+ LE+ ++N+ +
Sbjct: 1722 ELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQ 1781
Query: 960 CKEKEEKINKIKLVAVKAKKELDSSRKETQTVK------------------------EEL 995
+ + + K+E+ S K+ Q ++L
Sbjct: 1782 MSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKL 1841
Query: 996 ESLRSEKDQL----SASMRDLIQGAESY------------KNLLLEYEK----------- 1028
+ L +E+ QL + ++ ++Q ++ NLL +++K
Sbjct: 1842 DHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPT 1901
Query: 1029 QSEQLDVEKERANNFEHRIEDLTR---QLRNSTLQCETINSDNEDL----------LARI 1075
+ E+L +++E + F+ R Q+ + + ETI+ +NE L L +
Sbjct: 1902 EQEKLSLKRE-CDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEM 1960
Query: 1076 ETLQSNAK------LLEVQILEVQRAKAMVDKE---------LEAEKLQK--EQKIKEHA 1118
+ L+S A ++Q+L+ Q+A MV +E L+AE++ + +++++
Sbjct: 1961 QHLRSTATPSPSPHAWDLQLLQ-QQACPMVPREQFLQLQRQLLQAERINQHLQEELENRT 2019
Query: 1119 TTVNELEELQVQLQKE-KKQLQKTMQELELVKKDAQQTTLMNMEI----ADYERLMKELN 1173
+ N + Q QL ++++ + Q+L+LVK+ Q+ E + ++K+L
Sbjct: 2020 SETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLY 2079
Query: 1174 QKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQ 1212
+ +E EQ K ++K L+E+I SL + V+
Sbjct: 2080 VENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNIVR 2118
Score = 100 bits (250), Expect = 9e-21
Identities = 218/1046 (20%), Positives = 418/1046 (39%), Gaps = 183/1046 (17%)
Query: 625 LELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLS 684
+E +++ + + ++ + + ELT LE N+ + K + L+ K
Sbjct: 319 IENSQEILKALDFSLDGNINLTELTLALE--------NELLVTKNSIHQAALASFK---- 366
Query: 685 AEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKL 744
AE++ L E +++ EK++L DL+ + EK LM E D+ +
Sbjct: 367 AEIRHLLERVDQVVREKEKLRSDLD----------------KAEKLKSLMASEVDDHHAA 410
Query: 745 LENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEE----KCNL 800
+E L + Y KE + + + K+ +LQ G+ ++ +E K
Sbjct: 411 IERRNEYNLRKLDEEY---KERIAALKNEL-RKEREQILQQAGKQRLELEQEIEKAKTEE 466
Query: 801 AFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSD 860
+ RD L L KE L+ E + E+ L +YE L++ LE + +EK
Sbjct: 467 NYIRDRLALSL-KENSRLENELLENAEK----LAEYENLTNKLQRNLENVLAEKFG---- 517
Query: 861 LLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRD 920
++ ++ + L+ + L +++ NE E+ + + L Q EL +
Sbjct: 518 --DLDPSSAEFFLQEERL-------------TQMRNEYERQCRVLQDQVDEL--QSELEE 560
Query: 921 RRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKE 980
RA+ +L+ L SPS +E+E +E E E+ N + + +++A+
Sbjct: 561 YRAQGRVLRLPLKNSPS---------EEVEANSGGIEPEHGLGSEECNPLNM-SIEAELV 610
Query: 981 LDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERA 1040
++ +++ RD+ ++ + YEKQ ++ V ++A
Sbjct: 611 IEQMKEQHH--------------------RDICCLRLELEDKVRHYEKQLDETVVSCKKA 650
Query: 1041 NNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEV----QRAK 1096
E++ ++ N T T+ DL I LQ A +L+ E + K
Sbjct: 651 Q------ENMKQRHENET---HTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEK 701
Query: 1097 AMVDKELEAEK--LQKEQKIKEHATTVNELEELQVQLQKEKKQLQKT----------MQE 1144
+ +LE EK LQ++ +++ L + Q ++E++ LQ + QE
Sbjct: 702 KQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
Query: 1145 LELVKKDAQQTTLMNMEIADYERLMKELNQK----LTNKNNKIED--LEQEIKIQKQKQE 1198
LE ++ Q T+L+ + E L KEL +K L K+E + +I+ Q Q
Sbjct: 762 LEQFHQE-QLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQS 820
Query: 1199 TLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQ 1258
Q+ +S++Q E + + + L + ++E + E D L + + EL ++
Sbjct: 821 DCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQEL--LKE 878
Query: 1259 QVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTS 1318
++ K +T E+ E L+ + ++H ++ +Q++ E+ R Q ++ S
Sbjct: 879 TLKREKTTSLVLTQER----EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLS 934
Query: 1319 E--FESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQ----LKIKLQDSQNNL 1372
+ E + ++++ + A + A Q E LEM DQ + KL +N
Sbjct: 935 DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH 994
Query: 1373 QINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQ--TVS 1430
+ ++E T + R LQ + + + L +QS ++ E +
Sbjct: 995 KATCETADRERAEMSTEISR----LQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL 1050
Query: 1431 QLTSQNEVLRNSFRDQVRHLQEEHRKTVE----------TLQQQLSKMEAQLFQLK--NE 1478
L Q E L D + LQ H + V+ LQQ+L K+E L +E
Sbjct: 1051 SLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDE 1110
Query: 1479 PTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTR---------EEGEGMETTDTESV--- 1526
P T ++ + + ++ T + VTR +E + +T T SV
Sbjct: 1111 PATEFFGNTAEQTEPFLQQNRTK----QVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQ 1166
Query: 1527 ----SSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRET 1582
+ + +L NS ET+ E W + +L ++L D R +
Sbjct: 1167 EVKIEESEASVEGFSELENSEETRTES--WELKNQISQLQEQLMMLCADCD------RAS 1218
Query: 1583 EATNAILMEQIKLLKSEIRRLERNQE 1608
E +L + + +LK +++ LER E
Sbjct: 1219 EKKQDLLFD-VSVLKKKLKMLERIPE 1243
Score = 89.4 bits (220), Expect = 3e-17
Identities = 154/689 (22%), Positives = 266/689 (38%), Gaps = 127/689 (18%)
Query: 1022 LLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSN 1081
L LE E + + + +F+ I L ++ + E + SD L
Sbjct: 344 LALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD----------LDKA 393
Query: 1082 AKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEH-ATTVNELEELQVQ-LQKEKKQLQ 1139
KL + EV A +++ E + +++ KE A NEL + + Q LQ+ KQ
Sbjct: 394 EKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRL 453
Query: 1140 KTMQELELVKKDA-----------------QQTTLMNME-IADYERLMKELNQKLTNK-N 1180
+ QE+E K + + L N E +A+YE L +L + L N
Sbjct: 454 ELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLA 513
Query: 1181 NKIEDLE--------QEIKIQKQKQE------TLQEEITSLQSSVQQYEEKNTKIKQLLV 1226
K DL+ QE ++ + + E LQ+++ LQS +++Y + ++ L
Sbjct: 514 EKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLK 573
Query: 1227 KTKKEL--ADSKQAETDHLI-------LQASLKGELEASQQQ-----------------V 1260
+ E A+S E +H + L S++ EL Q + V
Sbjct: 574 NSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKV 633
Query: 1261 EVYKIQLAEITSEKHKIHEHLKTSAEQHQRTL----SAYQQRVTALQEECRAAKAEQATV 1316
Y+ QL E K E++K E TL S + + LQ + K
Sbjct: 634 RHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEA 693
Query: 1317 TSEFESYKVRVHNVLKQQKN----KSMSQAETE----------GAKQEREHL------EM 1356
T E K ++ L+++K K Q E E ++ERE L E
Sbjct: 694 TCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEE 753
Query: 1357 LIDQLKIKLQDSQNNLQINVSELQTLQSEH--DTLLERHNKMLQETVSK-EAELREKLCS 1413
+ L +L+ ++ E TL+ E LLE+H + LQE K E E +
Sbjct: 754 KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 813
Query: 1414 IQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLF 1473
I+++ +S+ + + S + L +R +++ LQE+ R+ E +
Sbjct: 814 IEAQ---FQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE------------EKSQW 858
Query: 1474 QLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYT 1533
+ + + T+ +Q+ LK +R T V +E E +E T E ++S
Sbjct: 859 EFEKDELTQECAEAQELLKETLKREKTT------SLVLTQEREMLEKTYKEHLNSMVVER 912
Query: 1534 QSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQI 1593
Q L Q L L + T++ L+ KS+ RE A EQ+
Sbjct: 913 QQLLQDLED--------LRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQL 964
Query: 1594 KLLKSEIRRLERNQEREKSAANLEYLKNV 1622
+ E +E +QER++ + L ++N+
Sbjct: 965 ASQRLERLEMEHDQERQEMMSKLLAMENI 993
Score = 89.4 bits (220), Expect = 3e-17
Identities = 152/719 (21%), Positives = 308/719 (42%), Gaps = 102/719 (14%)
Query: 21 KLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDA 80
+LE ++L + K+++ ++ K K + EKE EEL K + + ++++
Sbjct: 1455 ELEKTKLQELTRKLKERVTILVKQKDVLSHGEKE-EEL--KAMMHDLQITCSEMQQKVEL 1511
Query: 81 LLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMA 140
L E + +Q+ L+ E + +E S K+G + E+ ++ E +K E A
Sbjct: 1512 LRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMW----QKTETVKQENAA 1567
Query: 141 VRSKYSEDKANLQKQLEEAM--NTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQI 198
V+ NL+KQ+ E N QL+L Q NS++ QE+++++ E +
Sbjct: 1568 VQKMVE----NLKKQISELKIKNQQLDLENTELSQKNSQN-----QEKLQELNQRLTEML 1618
Query: 199 LYLQKQL-DATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKA---IHQEEVKE 254
+K+ ++ +E+++ L+ +E ++SL+ EL ++K I Q+E
Sbjct: 1619 CQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHL 1678
Query: 255 LMCQIEASAKEH--------EAEINKLNELKENLVKQCEASEKN----IQKKYECELENL 302
L ++E + H + +I+ + E L+K+ EA + + K + L
Sbjct: 1679 LKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEH 1738
Query: 303 RKATSNANQDN-QICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDE--VTYMN 359
R AT Q + + S L+ Q EKV++LEDT++ + Q S +K + VT
Sbjct: 1739 RIATMKQEQKSWEHQSASLKSQLVASQ---EKVQNLEDTVQNVNLQMSRMKSDLRVTQQE 1795
Query: 360 NLKLKLEMDAQHIKDE-----------------FFHEREDLEFKINELLLAKEEQGC--V 400
LK E+ + H + + ++++ L + + L+ +E+Q
Sbjct: 1796 KEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQE 1855
Query: 401 IEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQ 460
E+L++ + + ++ E+ + +L +HQK ++ ++ +E+EKL+L
Sbjct: 1856 NERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT--MNPTEQEKLSL----- 1908
Query: 461 GLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520
K +C+ Q+E+ A + + + L+T I E E +K++Q +L
Sbjct: 1909 --KRECDQFQKEQSPANRKVSQMNSLEQELET--------IHLENEGLKKKQVKLDEQLM 1958
Query: 521 --QKLRTAFTEKDA-------LLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVY 571
Q LR+ T + LL+ E+ L Q + + E ++LQE
Sbjct: 1959 EMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQE----- 2013
Query: 572 LLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKV 631
ELE + + + + + E M +K + +RL+ E ++
Sbjct: 2014 ------------ELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQL 2061
Query: 632 EQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSL 690
++ + N++ + V +L + LK + +Q+ + + +L E LS V++L
Sbjct: 2062 KEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNIVRNL 2120
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 206 bits (524), Expect = 2e-52
Identities = 371/1709 (21%), Positives = 711/1709 (41%), Gaps = 259/1709 (15%)
Query: 27 KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKA 86
+ DL K K + ++ + +E+ E + + E + I AL L +
Sbjct: 393 RSDLDKAEKLKSLMASEVDDHHAAIERR-NEYNLRKLDEEYKERIAALKNEL------RK 445
Query: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146
E EQ K+ ++++QE+E + T+ L S +KE L+NEL+ K +
Sbjct: 446 EREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS----LKENSRLENELLENAEKLA 501
Query: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
E + NL +L+ N + L+E+ + S +E + ++R +E Q LQ Q+D
Sbjct: 502 EYE-NLTNKLQR--NLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD 558
Query: 207 ATTDEKKETVTQ-------LQNI----IEANSQHYQKNIN-----------SLQEELL-- 242
E +E Q L+N +EANS + S++ EL+
Sbjct: 559 ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 618
Query: 243 QLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENL 302
Q+K H ++ L ++E + +E ++ + V C+ +++N+++++E E L
Sbjct: 619 QMKEQHHRDICCLRLELEDKVRHYEKQL-------DETVVSCKKAQENMKQRHENETHTL 671
Query: 303 RKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLK---ELESQHSILKDEVTYMN 359
K S+ N+I + Q E +H E+ + +LE + + L++++ +
Sbjct: 672 EKQISDLK--NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQH 729
Query: 360 NLKLKLEMDAQHIKDEFFHEREDL------EFKINELL-----LAKEEQGCVIEKLKSEL 408
++LK + + F ERE L E K+ L +E+ ++EK E
Sbjct: 730 EMELKARL--TQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEK 787
Query: 409 AGLNKQFCYTVEQHNREVQSLKEQHQKE----ISELNETFLSDSEKEKLTLMFEIQGL-- 462
L K+ +E+H RE+Q +E+ + E S++ F SD +K +Q L
Sbjct: 788 EELRKEL---LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG 844
Query: 463 --KEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520
+++ ++LQ++++E +E ++ E+ Q E E+ + E++K+++ + + Q
Sbjct: 845 RYRQELKDLQEQQREEKSQWEFEKD--ELTQ-ECAEAQELLK---ETLKREKTTSLVLTQ 898
Query: 521 QK----------LRTAFTEKDALLETVNRLQGENE---KLLSQQELVPELENTIK-NLQE 566
++ L + E+ LL+ + L+ +E LLS Q L EL+++ K L+E
Sbjct: 899 EREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQIL--ELKSSHKRELRE 956
Query: 567 KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHK-KCEREERLIL 625
+ V + + + LE +E+ + ++KL M+N HK CE +R
Sbjct: 957 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLL----AMENIHKATCETADRERA 1012
Query: 626 ELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA 685
E+ ++ + L+ +KE Q L L +V+ E+ EV
Sbjct: 1013 EMSTEISR------------------LQSKIKEMQQATSPLSMLQSGCQVIGEE-EVEGD 1053
Query: 686 EVKSLYEENNKLSSEKKQLSRDLEVFLSQ--KEDVILKEHITQLEKKLQLMVEEQDNLNK 743
SL ++ +L E + L+ Q KE+V + I++L+++LQ + E +
Sbjct: 1054 GALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKL--EPGLVMS 1111
Query: 744 LLENEQVQKLFVKT--QLYGFLKEMGSEVSE--------DSEEKDVVNVLQAVGESLAKI 793
+E + F T Q FL++ ++ E E D V L + G S +
Sbjct: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1171
Query: 794 NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE 853
E K + E ELE EE+ + ELK+ + +++ ++L + + +
Sbjct: 1172 QEVKIEESEASVEGFSELEN-----SEETRTESWELKNQISQLQEQLMMLCADCDRASEK 1226
Query: 854 KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913
K+ L D+ +K L +E + + K ++ E +E++ L+ L
Sbjct: 1227 KQDLLFDVSVLKKK-----------LKMLERIPEASPKYKLLYEDVS---RENDCLQEEL 1272
Query: 914 EQKELR---------DRRAELILLKDSLAKSPSVKNDPLSSVKELEE-KIENLEKE--CK 961
E R + AE+ L+D L K V LS K +E KIEN E
Sbjct: 1273 RMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVL 1332
Query: 962 EKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKD----QLSASMRDLIQGAE 1017
+ KI K++ V+ R + + LE+L E D QL+ ++ + +
Sbjct: 1333 RLQGKIEKLQESVVQ--------RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVR 1384
Query: 1018 SYKNLLLEYEKQSEQLD-----VEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLL 1072
S +++ E +++++ L+ +EK +A+ + +Q + I
Sbjct: 1385 SVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVI-------- 1436
Query: 1073 ARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQK-EQKIKEHATTVNELEELQVQL 1131
L+ N LL Q Q + + ELE KLQ+ +K+KE T + + +++
Sbjct: 1437 -----LEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHG 1491
Query: 1132 QKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIK 1191
+KE ++L+ M +L++ + QQ +E+ YE ++L Q+ + N+I L +E
Sbjct: 1492 EKE-EELKAMMHDLQITCSEMQQ----KVELLRYE--SEKLQQENSILRNEITTLNEEDS 1544
Query: 1192 IQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKG 1251
I K TL + + +++N +++++ KK++++ K + L
Sbjct: 1545 ISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQ 1604
Query: 1252 ELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKA 1311
+ +Q++++ +L E+ +K K E L +Q L+EE K
Sbjct: 1605 KNSQNQEKLQELNQRLTEMLCQKEK---------EPGNSALEEREQEKFNLKEELERCKV 1655
Query: 1312 EQATVTS--EFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQ 1369
+ +T+ S E E +V++ + QQ+N + K E E ++ L L D Q
Sbjct: 1656 QSSTLVSSLEAELSEVKIQTHIVQQENHLL--------KDELEKMKQL--HRCPDLSDFQ 1705
Query: 1370 NNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTV 1429
+ +S + L E + L E N + + ++K + L ++ +++ E + +
Sbjct: 1706 QKISSVLSYNEKLLKEKEALSEELNSCV-DKLAKSSLLEHRIATMKQEQKSWEHQSASLK 1764
Query: 1430 SQLTSQNEVLRN------SFRDQVRHLQEEHRKT---VETLQQQLSKMEAQLFQLKNEPT 1480
SQL + E ++N + Q+ ++ + R T E L+Q++ + QL +
Sbjct: 1765 SQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSW 1824
Query: 1481 TRSPVSSQQSLKNLRERRNTDLPLLDMHTVTRE------EGEGMET----TDTESVSSAS 1530
+ L N ++R + D LD H + E E E ++T T E S
Sbjct: 1825 APEIATHPSGLHNQQKRLSWD--KLD-HLMNEEQQLLWQENERLQTMVQNTKAELTHSRE 1881
Query: 1531 TYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQK---------LSSTTKSADHLNGLLRE 1581
Q LL + L P +E+L K S + +N L +E
Sbjct: 1882 KVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1941
Query: 1582 TEATNAILMEQIKLLKSEIRRLERNQERE 1610
E I +E L K +++ E+ E +
Sbjct: 1942 LE---TIHLENEGLKKKQVKLDEQLMEMQ 1967
Score = 192 bits (489), Expect = 2e-48
Identities = 347/1688 (20%), Positives = 720/1688 (42%), Gaps = 262/1688 (15%)
Query: 25 LPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSK------PVTEGTGDIIKA----- 73
L +E L + + + + + EL+ E+EE R++ P+ + ++A
Sbjct: 534 LQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGI 593
Query: 74 -------------LTERLDALLLEKAETEQQ-----CLSLKKENI--KMKQEVEDSVTKM 113
L ++A L+ + EQ CL L+ E+ +++++++V
Sbjct: 594 EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSC 653
Query: 114 GDAHKELEQSHINYV----KEIENLKNELMAVRS--------------KYSEDKANLQKQ 155
A + ++Q H N K+I +LKNE+ ++ ++ E+K LQ +
Sbjct: 654 KKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVK 713
Query: 156 LEEAMNTQLELSEQLKFQNNSE--DNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKK 213
LEE + L E+L+ Q+ E + + Q E+ R G + +K T + ++
Sbjct: 714 LEE---EKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ 770
Query: 214 ETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEIN-K 272
QL +++E ++ ++ L++ELL+ HQ E++E ++E ++I +
Sbjct: 771 FHQEQLTSLVEKHTLEKEE----LRKELLEK---HQRELQEGREKMETECNRRTSQIEAQ 823
Query: 273 LNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQI-CSILLQENTFVEQVVN 331
+ + ++CE++ ++++ +Y EL++L++ + L QE ++++
Sbjct: 824 FQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLK 883
Query: 332 EKVKHLEDTLKELESQHSILKDEVTYMNNL------KLKLEMDAQHIKDEFFHEREDLEF 385
E +K + T L + +L E TY +L + +L D + +++ ++ L
Sbjct: 884 ETLKREKTTSLVLTQEREML--EKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSD 941
Query: 386 KINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFL 445
+I EL + + + E++ + AG ++Q ++ ++ L+ +H +E E+ L
Sbjct: 942 QILELKSSHKRELREREEVLCQ-AGASEQLA------SQRLERLEMEHDQERQEMMSKLL 994
Query: 446 S----------DSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELG 495
+ +++E+ + EI L+ + + +QQ + + I E + G
Sbjct: 995 AMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE--EEVEG 1052
Query: 496 ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEK----LLSQQ 551
+ A + Q+ E + ++ + LQ+ A E + ++RLQ +K L+
Sbjct: 1053 DGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSS 1112
Query: 552 ELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEG--KINSLTEEKDDFINKL-KNSHE 608
L N E+ +L + K++EG + + L++ +DD + L
Sbjct: 1113 CLDEPATEFFGNTAEQTEPFL-----QQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTS 1167
Query: 609 EMDNFHKKCEREERLILELG--KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKL 666
+ K E E + + E+T + EL+ ++++L L + D+ +K
Sbjct: 1168 SVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKK 1227
Query: 667 EKLMVQMKVLSEDKEVL------SAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVIL 720
+ L+ + VL + ++L S + K LYE+ +S E L +L + ++ ++
Sbjct: 1228 QDLLFDVSVLKKKLKMLERIPEASPKYKLLYED---VSRENDCLQEELRMMETRYDEA-- 1282
Query: 721 KEHITQLEKKLQLMVEE---QDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEK 777
LE +L E QD L K+ E+V + F+ L++ EV ++EE
Sbjct: 1283 ------LENNKELTAEVFRLQDELKKM---EEVTETFLS------LEKSYDEVKIENEEL 1327
Query: 778 DVVNV-LQAVGESLAKINEEKC----------NLAFQRDEKVLELEKEIKCLQEESVVQC 826
+V+ + LQ E L + ++C NL + D +L+L + + EE V +
Sbjct: 1328 NVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTL----EECVPRV 1383
Query: 827 EELKSLLRDYEQEKVLLR---KELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVE 883
+ ++ + +QE L + LE++++ + A ++ E+ R++NQ +L
Sbjct: 1384 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQ--THQERPRVQNQVIL---- 1437
Query: 884 EVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQ--KELRDRRAELILLKDSLAKSPSVKND 941
E + T + + + + I E E K L++ ++L++R L+ KD L+
Sbjct: 1438 EENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHG------ 1491
Query: 942 PLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSE 1001
+EL+ + +L+ C E ++K+ ++ + K ++E R E T+ EE +
Sbjct: 1492 --EKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLK 1549
Query: 1002 KDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQC 1061
L+ S ++ Q E+ K E + Q VE + E +I++ L N+ L
Sbjct: 1550 LGTLNGSQEEMWQKTETVKQ-----ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQ 1604
Query: 1062 ETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTV 1121
+ NS N++ L + N +L E+ + KE E E++ +E
Sbjct: 1605 K--NSQNQEKLQEL-----NQRLTEM----------LCQKEKEPGNSALEEREQEKFNLK 1647
Query: 1122 NELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNN 1181
ELE +VQ L+ + E+++ QQ N + D MK+L ++
Sbjct: 1648 EELERCKVQSSTLVSSLEAELSEVKIQTHIVQQE---NHLLKDELEKMKQL-----HRCP 1699
Query: 1182 KIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETD 1241
+ D +Q+I E L +E +L + +K K L + +A KQ +
Sbjct: 1700 DLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLL----EHRIATMKQEQKS 1755
Query: 1242 HLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTA 1301
ASLK +L ASQ++V+ + + + + ++ L+ + ++ + A +Q V +
Sbjct: 1756 WEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKE----ALKQEVMS 1811
Query: 1302 LQEECRAAKAEQATVTSEFESYKVRVHNVLKQ---QKNKSMSQAETEGAKQEREHLEMLI 1358
L ++ + A + + E ++ +HN K+ K + E + QE E L+ ++
Sbjct: 1812 LHKQLQNAGGK--SWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMV 1869
Query: 1359 DQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSEN 1418
K +L S+ V +L++ LL +H K L + + +EKL S++ E
Sbjct: 1870 QNTKAELTHSRE----KVRQLES------NLLPKHQKHLNPSGTMNPTEQEKL-SLKREC 1918
Query: 1419 MMMKSEHT---QTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQL 1475
+ E + + VSQ+ S + L + HL+ E L+++ K++ QL ++
Sbjct: 1919 DQFQKEQSPANRKVSQMNSLEQEL------ETIHLEN------EGLKKKQVKLDEQLMEM 1966
Query: 1476 KNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHT---VTREEGEGMETTDTESVSSASTY 1532
++ +T +P S + DL LL V RE+ ++ + A
Sbjct: 1967 QHLRSTATPSPSPHA---------WDLQLLQQQACPMVPREQFLQLQ----RQLLQAERI 2013
Query: 1533 TQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQ 1592
Q L++ L + ++ P + +E+LV T + + + ++ + +L E+
Sbjct: 2014 NQHLQEELENRTSETNTP----QGNQEQLV------TVMEERMIEVEQKLKLVKRLLQEK 2063
Query: 1593 IKLLKSEI 1600
+ LK ++
Sbjct: 2064 VNQLKEQV 2071
Score = 100 bits (250), Expect = 9e-21
Identities = 218/1046 (20%), Positives = 418/1046 (39%), Gaps = 183/1046 (17%)
Query: 625 LELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLS 684
+E +++ + + ++ + + ELT LE N+ + K + L+ K
Sbjct: 325 IENSQEILKALDFSLDGNINLTELTLALE--------NELLVTKNSIHQAALASFK---- 372
Query: 685 AEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKL 744
AE++ L E +++ EK++L DL+ + EK LM E D+ +
Sbjct: 373 AEIRHLLERVDQVVREKEKLRSDLD----------------KAEKLKSLMASEVDDHHAA 416
Query: 745 LENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEE----KCNL 800
+E L + Y KE + + + K+ +LQ G+ ++ +E K
Sbjct: 417 IERRNEYNLRKLDEEY---KERIAALKNEL-RKEREQILQQAGKQRLELEQEIEKAKTEE 472
Query: 801 AFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSD 860
+ RD L L KE L+ E + E+ L +YE L++ LE + +EK
Sbjct: 473 NYIRDRLALSL-KENSRLENELLENAEK----LAEYENLTNKLQRNLENVLAEKFG---- 523
Query: 861 LLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRD 920
++ ++ + L+ + L +++ NE E+ + + L Q EL +
Sbjct: 524 --DLDPSSAEFFLQEERL-------------TQMRNEYERQCRVLQDQVDEL--QSELEE 566
Query: 921 RRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKE 980
RA+ +L+ L SPS +E+E +E E E+ N + + +++A+
Sbjct: 567 YRAQGRVLRLPLKNSPS---------EEVEANSGGIEPEHGLGSEECNPLNM-SIEAELV 616
Query: 981 LDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERA 1040
++ +++ RD+ ++ + YEKQ ++ V ++A
Sbjct: 617 IEQMKEQHH--------------------RDICCLRLELEDKVRHYEKQLDETVVSCKKA 656
Query: 1041 NNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEV----QRAK 1096
E++ ++ N T T+ DL I LQ A +L+ E + K
Sbjct: 657 Q------ENMKQRHENET---HTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEK 707
Query: 1097 AMVDKELEAEK--LQKEQKIKEHATTVNELEELQVQLQKEKKQLQKT----------MQE 1144
+ +LE EK LQ++ +++ L + Q ++E++ LQ + QE
Sbjct: 708 KQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 767
Query: 1145 LELVKKDAQQTTLMNMEIADYERLMKELNQK----LTNKNNKIED--LEQEIKIQKQKQE 1198
LE ++ Q T+L+ + E L KEL +K L K+E + +I+ Q Q
Sbjct: 768 LEQFHQE-QLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQS 826
Query: 1199 TLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQ 1258
Q+ +S++Q E + + + L + ++E + E D L + + EL ++
Sbjct: 827 DCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQEL--LKE 884
Query: 1259 QVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTS 1318
++ K +T E+ E L+ + ++H ++ +Q++ E+ R Q ++ S
Sbjct: 885 TLKREKTTSLVLTQER----EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLS 940
Query: 1319 E--FESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQ----LKIKLQDSQNNL 1372
+ E + ++++ + A + A Q E LEM DQ + KL +N
Sbjct: 941 DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH 1000
Query: 1373 QINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQ--TVS 1430
+ ++E T + R LQ + + + L +QS ++ E +
Sbjct: 1001 KATCETADRERAEMSTEISR----LQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL 1056
Query: 1431 QLTSQNEVLRNSFRDQVRHLQEEHRKTVE----------TLQQQLSKMEAQLFQLK--NE 1478
L Q E L D + LQ H + V+ LQQ+L K+E L +E
Sbjct: 1057 SLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDE 1116
Query: 1479 PTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTR---------EEGEGMETTDTESV--- 1526
P T ++ + + ++ T + VTR +E + +T T SV
Sbjct: 1117 PATEFFGNTAEQTEPFLQQNRTK----QVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQ 1172
Query: 1527 ----SSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRET 1582
+ + +L NS ET+ E W + +L ++L D R +
Sbjct: 1173 EVKIEESEASVEGFSELENSEETRTES--WELKNQISQLQEQLMMLCADCD------RAS 1224
Query: 1583 EATNAILMEQIKLLKSEIRRLERNQE 1608
E +L + + +LK +++ LER E
Sbjct: 1225 EKKQDLLFD-VSVLKKKLKMLERIPE 1249
Score = 89.4 bits (220), Expect = 3e-17
Identities = 154/689 (22%), Positives = 266/689 (38%), Gaps = 127/689 (18%)
Query: 1022 LLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSN 1081
L LE E + + + +F+ I L ++ + E + SD L
Sbjct: 350 LALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD----------LDKA 399
Query: 1082 AKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEH-ATTVNELEELQVQ-LQKEKKQLQ 1139
KL + EV A +++ E + +++ KE A NEL + + Q LQ+ KQ
Sbjct: 400 EKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRL 459
Query: 1140 KTMQELELVKKDA-----------------QQTTLMNME-IADYERLMKELNQKLTNK-N 1180
+ QE+E K + + L N E +A+YE L +L + L N
Sbjct: 460 ELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLA 519
Query: 1181 NKIEDLE--------QEIKIQKQKQE------TLQEEITSLQSSVQQYEEKNTKIKQLLV 1226
K DL+ QE ++ + + E LQ+++ LQS +++Y + ++ L
Sbjct: 520 EKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLK 579
Query: 1227 KTKKEL--ADSKQAETDHLI-------LQASLKGELEASQQQ-----------------V 1260
+ E A+S E +H + L S++ EL Q + V
Sbjct: 580 NSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKV 639
Query: 1261 EVYKIQLAEITSEKHKIHEHLKTSAEQHQRTL----SAYQQRVTALQEECRAAKAEQATV 1316
Y+ QL E K E++K E TL S + + LQ + K
Sbjct: 640 RHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEA 699
Query: 1317 TSEFESYKVRVHNVLKQQKN----KSMSQAETE----------GAKQEREHL------EM 1356
T E K ++ L+++K K Q E E ++ERE L E
Sbjct: 700 TCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEE 759
Query: 1357 LIDQLKIKLQDSQNNLQINVSELQTLQSEH--DTLLERHNKMLQETVSK-EAELREKLCS 1413
+ L +L+ ++ E TL+ E LLE+H + LQE K E E +
Sbjct: 760 KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 819
Query: 1414 IQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLF 1473
I+++ +S+ + + S + L +R +++ LQE+ R+ E +
Sbjct: 820 IEAQ---FQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE------------EKSQW 864
Query: 1474 QLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYT 1533
+ + + T+ +Q+ LK +R T V +E E +E T E ++S
Sbjct: 865 EFEKDELTQECAEAQELLKETLKREKTT------SLVLTQEREMLEKTYKEHLNSMVVER 918
Query: 1534 QSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQI 1593
Q L Q L L + T++ L+ KS+ RE A EQ+
Sbjct: 919 QQLLQDLED--------LRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQL 970
Query: 1594 KLLKSEIRRLERNQEREKSAANLEYLKNV 1622
+ E +E +QER++ + L ++N+
Sbjct: 971 ASQRLERLEMEHDQERQEMMSKLLAMENI 999
>gi|33946321 ninein isoform 5 [Homo sapiens]
Length = 2090
Score = 206 bits (524), Expect = 2e-52
Identities = 371/1709 (21%), Positives = 711/1709 (41%), Gaps = 259/1709 (15%)
Query: 27 KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKA 86
+ DL K K + ++ + +E+ E + + E + I AL L +
Sbjct: 387 RSDLDKAEKLKSLMASEVDDHHAAIERR-NEYNLRKLDEEYKERIAALKNEL------RK 439
Query: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146
E EQ K+ ++++QE+E + T+ L S +KE L+NEL+ K +
Sbjct: 440 EREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS----LKENSRLENELLENAEKLA 495
Query: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
E + NL +L+ N + L+E+ + S +E + ++R +E Q LQ Q+D
Sbjct: 496 EYE-NLTNKLQR--NLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD 552
Query: 207 ATTDEKKETVTQ-------LQNI----IEANSQHYQKNIN-----------SLQEELL-- 242
E +E Q L+N +EANS + S++ EL+
Sbjct: 553 ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 612
Query: 243 QLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENL 302
Q+K H ++ L ++E + +E ++ + V C+ +++N+++++E E L
Sbjct: 613 QMKEQHHRDICCLRLELEDKVRHYEKQL-------DETVVSCKKAQENMKQRHENETHTL 665
Query: 303 RKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLK---ELESQHSILKDEVTYMN 359
K S+ N+I + Q E +H E+ + +LE + + L++++ +
Sbjct: 666 EKQISDLK--NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQH 723
Query: 360 NLKLKLEMDAQHIKDEFFHEREDL------EFKINELL-----LAKEEQGCVIEKLKSEL 408
++LK + + F ERE L E K+ L +E+ ++EK E
Sbjct: 724 EMELKARL--TQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEK 781
Query: 409 AGLNKQFCYTVEQHNREVQSLKEQHQKE----ISELNETFLSDSEKEKLTLMFEIQGL-- 462
L K+ +E+H RE+Q +E+ + E S++ F SD +K +Q L
Sbjct: 782 EELRKEL---LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG 838
Query: 463 --KEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520
+++ ++LQ++++E +E ++ E+ Q E E+ + E++K+++ + + Q
Sbjct: 839 RYRQELKDLQEQQREEKSQWEFEKD--ELTQ-ECAEAQELLK---ETLKREKTTSLVLTQ 892
Query: 521 QK----------LRTAFTEKDALLETVNRLQGENE---KLLSQQELVPELENTIK-NLQE 566
++ L + E+ LL+ + L+ +E LLS Q L EL+++ K L+E
Sbjct: 893 EREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQIL--ELKSSHKRELRE 950
Query: 567 KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHK-KCEREERLIL 625
+ V + + + LE +E+ + ++KL M+N HK CE +R
Sbjct: 951 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLL----AMENIHKATCETADRERA 1006
Query: 626 ELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA 685
E+ ++ + L+ +KE Q L L +V+ E+ EV
Sbjct: 1007 EMSTEISR------------------LQSKIKEMQQATSPLSMLQSGCQVIGEE-EVEGD 1047
Query: 686 EVKSLYEENNKLSSEKKQLSRDLEVFLSQ--KEDVILKEHITQLEKKLQLMVEEQDNLNK 743
SL ++ +L E + L+ Q KE+V + I++L+++LQ + E +
Sbjct: 1048 GALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKL--EPGLVMS 1105
Query: 744 LLENEQVQKLFVKT--QLYGFLKEMGSEVSE--------DSEEKDVVNVLQAVGESLAKI 793
+E + F T Q FL++ ++ E E D V L + G S +
Sbjct: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
Query: 794 NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE 853
E K + E ELE EE+ + ELK+ + +++ ++L + + +
Sbjct: 1166 QEVKIEESEASVEGFSELEN-----SEETRTESWELKNQISQLQEQLMMLCADCDRASEK 1220
Query: 854 KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913
K+ L D+ +K L +E + + K ++ E +E++ L+ L
Sbjct: 1221 KQDLLFDVSVLKKK-----------LKMLERIPEASPKYKLLYEDVS---RENDCLQEEL 1266
Query: 914 EQKELR---------DRRAELILLKDSLAKSPSVKNDPLSSVKELEE-KIENLEKE--CK 961
E R + AE+ L+D L K V LS K +E KIEN E
Sbjct: 1267 RMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVL 1326
Query: 962 EKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKD----QLSASMRDLIQGAE 1017
+ KI K++ V+ R + + LE+L E D QL+ ++ + +
Sbjct: 1327 RLQGKIEKLQESVVQ--------RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVR 1378
Query: 1018 SYKNLLLEYEKQSEQLD-----VEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLL 1072
S +++ E +++++ L+ +EK +A+ + +Q + I
Sbjct: 1379 SVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVI-------- 1430
Query: 1073 ARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQK-EQKIKEHATTVNELEELQVQL 1131
L+ N LL Q Q + + ELE KLQ+ +K+KE T + + +++
Sbjct: 1431 -----LEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHG 1485
Query: 1132 QKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIK 1191
+KE ++L+ M +L++ + QQ +E+ YE ++L Q+ + N+I L +E
Sbjct: 1486 EKE-EELKAMMHDLQITCSEMQQ----KVELLRYE--SEKLQQENSILRNEITTLNEEDS 1538
Query: 1192 IQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKG 1251
I K TL + + +++N +++++ KK++++ K + L
Sbjct: 1539 ISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQ 1598
Query: 1252 ELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKA 1311
+ +Q++++ +L E+ +K K E L +Q L+EE K
Sbjct: 1599 KNSQNQEKLQELNQRLTEMLCQKEK---------EPGNSALEEREQEKFNLKEELERCKV 1649
Query: 1312 EQATVTS--EFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQ 1369
+ +T+ S E E +V++ + QQ+N + K E E ++ L L D Q
Sbjct: 1650 QSSTLVSSLEAELSEVKIQTHIVQQENHLL--------KDELEKMKQL--HRCPDLSDFQ 1699
Query: 1370 NNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTV 1429
+ +S + L E + L E N + + ++K + L ++ +++ E + +
Sbjct: 1700 QKISSVLSYNEKLLKEKEALSEELNSCV-DKLAKSSLLEHRIATMKQEQKSWEHQSASLK 1758
Query: 1430 SQLTSQNEVLRN------SFRDQVRHLQEEHRKT---VETLQQQLSKMEAQLFQLKNEPT 1480
SQL + E ++N + Q+ ++ + R T E L+Q++ + QL +
Sbjct: 1759 SQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSW 1818
Query: 1481 TRSPVSSQQSLKNLRERRNTDLPLLDMHTVTRE------EGEGMET----TDTESVSSAS 1530
+ L N ++R + D LD H + E E E ++T T E S
Sbjct: 1819 APEIATHPSGLHNQQKRLSWD--KLD-HLMNEEQQLLWQENERLQTMVQNTKAELTHSRE 1875
Query: 1531 TYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQK---------LSSTTKSADHLNGLLRE 1581
Q LL + L P +E+L K S + +N L +E
Sbjct: 1876 KVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
Query: 1582 TEATNAILMEQIKLLKSEIRRLERNQERE 1610
E I +E L K +++ E+ E +
Sbjct: 1936 LE---TIHLENEGLKKKQVKLDEQLMEMQ 1961
Score = 192 bits (489), Expect = 2e-48
Identities = 347/1688 (20%), Positives = 720/1688 (42%), Gaps = 262/1688 (15%)
Query: 25 LPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSK------PVTEGTGDIIKA----- 73
L +E L + + + + + EL+ E+EE R++ P+ + ++A
Sbjct: 528 LQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGI 587
Query: 74 -------------LTERLDALLLEKAETEQQ-----CLSLKKENI--KMKQEVEDSVTKM 113
L ++A L+ + EQ CL L+ E+ +++++++V
Sbjct: 588 EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSC 647
Query: 114 GDAHKELEQSHINYV----KEIENLKNELMAVRS--------------KYSEDKANLQKQ 155
A + ++Q H N K+I +LKNE+ ++ ++ E+K LQ +
Sbjct: 648 KKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVK 707
Query: 156 LEEAMNTQLELSEQLKFQNNSE--DNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKK 213
LEE + L E+L+ Q+ E + + Q E+ R G + +K T + ++
Sbjct: 708 LEE---EKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ 764
Query: 214 ETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEIN-K 272
QL +++E ++ ++ L++ELL+ HQ E++E ++E ++I +
Sbjct: 765 FHQEQLTSLVEKHTLEKEE----LRKELLEK---HQRELQEGREKMETECNRRTSQIEAQ 817
Query: 273 LNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQI-CSILLQENTFVEQVVN 331
+ + ++CE++ ++++ +Y EL++L++ + L QE ++++
Sbjct: 818 FQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLK 877
Query: 332 EKVKHLEDTLKELESQHSILKDEVTYMNNL------KLKLEMDAQHIKDEFFHEREDLEF 385
E +K + T L + +L E TY +L + +L D + +++ ++ L
Sbjct: 878 ETLKREKTTSLVLTQEREML--EKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSD 935
Query: 386 KINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFL 445
+I EL + + + E++ + AG ++Q ++ ++ L+ +H +E E+ L
Sbjct: 936 QILELKSSHKRELREREEVLCQ-AGASEQLA------SQRLERLEMEHDQERQEMMSKLL 988
Query: 446 S----------DSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELG 495
+ +++E+ + EI L+ + + +QQ + + I E + G
Sbjct: 989 AMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE--EEVEG 1046
Query: 496 ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEK----LLSQQ 551
+ A + Q+ E + ++ + LQ+ A E + ++RLQ +K L+
Sbjct: 1047 DGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSS 1106
Query: 552 ELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEG--KINSLTEEKDDFINKL-KNSHE 608
L N E+ +L + K++EG + + L++ +DD + L
Sbjct: 1107 CLDEPATEFFGNTAEQTEPFL-----QQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTS 1161
Query: 609 EMDNFHKKCEREERLILELG--KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKL 666
+ K E E + + E+T + EL+ ++++L L + D+ +K
Sbjct: 1162 SVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKK 1221
Query: 667 EKLMVQMKVLSEDKEVL------SAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVIL 720
+ L+ + VL + ++L S + K LYE+ +S E L +L + ++ ++
Sbjct: 1222 QDLLFDVSVLKKKLKMLERIPEASPKYKLLYED---VSRENDCLQEELRMMETRYDEA-- 1276
Query: 721 KEHITQLEKKLQLMVEE---QDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEK 777
LE +L E QD L K+ E+V + F+ L++ EV ++EE
Sbjct: 1277 ------LENNKELTAEVFRLQDELKKM---EEVTETFLS------LEKSYDEVKIENEEL 1321
Query: 778 DVVNV-LQAVGESLAKINEEKC----------NLAFQRDEKVLELEKEIKCLQEESVVQC 826
+V+ + LQ E L + ++C NL + D +L+L + + EE V +
Sbjct: 1322 NVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTL----EECVPRV 1377
Query: 827 EELKSLLRDYEQEKVLLR---KELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVE 883
+ ++ + +QE L + LE++++ + A ++ E+ R++NQ +L
Sbjct: 1378 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQ--THQERPRVQNQVIL---- 1431
Query: 884 EVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQ--KELRDRRAELILLKDSLAKSPSVKND 941
E + T + + + + I E E K L++ ++L++R L+ KD L+
Sbjct: 1432 EENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHG------ 1485
Query: 942 PLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSE 1001
+EL+ + +L+ C E ++K+ ++ + K ++E R E T+ EE +
Sbjct: 1486 --EKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLK 1543
Query: 1002 KDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQC 1061
L+ S ++ Q E+ K E + Q VE + E +I++ L N+ L
Sbjct: 1544 LGTLNGSQEEMWQKTETVKQ-----ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQ 1598
Query: 1062 ETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTV 1121
+ NS N++ L + N +L E+ + KE E E++ +E
Sbjct: 1599 K--NSQNQEKLQEL-----NQRLTEM----------LCQKEKEPGNSALEEREQEKFNLK 1641
Query: 1122 NELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNN 1181
ELE +VQ L+ + E+++ QQ N + D MK+L ++
Sbjct: 1642 EELERCKVQSSTLVSSLEAELSEVKIQTHIVQQE---NHLLKDELEKMKQL-----HRCP 1693
Query: 1182 KIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETD 1241
+ D +Q+I E L +E +L + +K K L + +A KQ +
Sbjct: 1694 DLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLL----EHRIATMKQEQKS 1749
Query: 1242 HLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTA 1301
ASLK +L ASQ++V+ + + + + ++ L+ + ++ + A +Q V +
Sbjct: 1750 WEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKE----ALKQEVMS 1805
Query: 1302 LQEECRAAKAEQATVTSEFESYKVRVHNVLKQ---QKNKSMSQAETEGAKQEREHLEMLI 1358
L ++ + A + + E ++ +HN K+ K + E + QE E L+ ++
Sbjct: 1806 LHKQLQNAGGK--SWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMV 1863
Query: 1359 DQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSEN 1418
K +L S+ V +L++ LL +H K L + + +EKL S++ E
Sbjct: 1864 QNTKAELTHSRE----KVRQLES------NLLPKHQKHLNPSGTMNPTEQEKL-SLKREC 1912
Query: 1419 MMMKSEHT---QTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQL 1475
+ E + + VSQ+ S + L + HL+ E L+++ K++ QL ++
Sbjct: 1913 DQFQKEQSPANRKVSQMNSLEQEL------ETIHLEN------EGLKKKQVKLDEQLMEM 1960
Query: 1476 KNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHT---VTREEGEGMETTDTESVSSASTY 1532
++ +T +P S + DL LL V RE+ ++ + A
Sbjct: 1961 QHLRSTATPSPSPHA---------WDLQLLQQQACPMVPREQFLQLQ----RQLLQAERI 2007
Query: 1533 TQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQ 1592
Q L++ L + ++ P + +E+LV T + + + ++ + +L E+
Sbjct: 2008 NQHLQEELENRTSETNTP----QGNQEQLV------TVMEERMIEVEQKLKLVKRLLQEK 2057
Query: 1593 IKLLKSEI 1600
+ LK ++
Sbjct: 2058 VNQLKEQV 2065
Score = 100 bits (250), Expect = 9e-21
Identities = 218/1046 (20%), Positives = 418/1046 (39%), Gaps = 183/1046 (17%)
Query: 625 LELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLS 684
+E +++ + + ++ + + ELT LE N+ + K + L+ K
Sbjct: 319 IENSQEILKALDFSLDGNINLTELTLALE--------NELLVTKNSIHQAALASFK---- 366
Query: 685 AEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKL 744
AE++ L E +++ EK++L DL+ + EK LM E D+ +
Sbjct: 367 AEIRHLLERVDQVVREKEKLRSDLD----------------KAEKLKSLMASEVDDHHAA 410
Query: 745 LENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEE----KCNL 800
+E L + Y KE + + + K+ +LQ G+ ++ +E K
Sbjct: 411 IERRNEYNLRKLDEEY---KERIAALKNEL-RKEREQILQQAGKQRLELEQEIEKAKTEE 466
Query: 801 AFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSD 860
+ RD L L KE L+ E + E+ L +YE L++ LE + +EK
Sbjct: 467 NYIRDRLALSL-KENSRLENELLENAEK----LAEYENLTNKLQRNLENVLAEKFG---- 517
Query: 861 LLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRD 920
++ ++ + L+ + L +++ NE E+ + + L Q EL +
Sbjct: 518 --DLDPSSAEFFLQEERL-------------TQMRNEYERQCRVLQDQVDEL--QSELEE 560
Query: 921 RRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKE 980
RA+ +L+ L SPS +E+E +E E E+ N + + +++A+
Sbjct: 561 YRAQGRVLRLPLKNSPS---------EEVEANSGGIEPEHGLGSEECNPLNM-SIEAELV 610
Query: 981 LDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERA 1040
++ +++ RD+ ++ + YEKQ ++ V ++A
Sbjct: 611 IEQMKEQHH--------------------RDICCLRLELEDKVRHYEKQLDETVVSCKKA 650
Query: 1041 NNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEV----QRAK 1096
E++ ++ N T T+ DL I LQ A +L+ E + K
Sbjct: 651 Q------ENMKQRHENET---HTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEK 701
Query: 1097 AMVDKELEAEK--LQKEQKIKEHATTVNELEELQVQLQKEKKQLQKT----------MQE 1144
+ +LE EK LQ++ +++ L + Q ++E++ LQ + QE
Sbjct: 702 KQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQE 761
Query: 1145 LELVKKDAQQTTLMNMEIADYERLMKELNQK----LTNKNNKIED--LEQEIKIQKQKQE 1198
LE ++ Q T+L+ + E L KEL +K L K+E + +I+ Q Q
Sbjct: 762 LEQFHQE-QLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQS 820
Query: 1199 TLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQ 1258
Q+ +S++Q E + + + L + ++E + E D L + + EL ++
Sbjct: 821 DCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQEL--LKE 878
Query: 1259 QVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTS 1318
++ K +T E+ E L+ + ++H ++ +Q++ E+ R Q ++ S
Sbjct: 879 TLKREKTTSLVLTQER----EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLS 934
Query: 1319 E--FESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQ----LKIKLQDSQNNL 1372
+ E + ++++ + A + A Q E LEM DQ + KL +N
Sbjct: 935 DQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIH 994
Query: 1373 QINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQ--TVS 1430
+ ++E T + R LQ + + + L +QS ++ E +
Sbjct: 995 KATCETADRERAEMSTEISR----LQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL 1050
Query: 1431 QLTSQNEVLRNSFRDQVRHLQEEHRKTVE----------TLQQQLSKMEAQLFQLK--NE 1478
L Q E L D + LQ H + V+ LQQ+L K+E L +E
Sbjct: 1051 SLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDE 1110
Query: 1479 PTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTR---------EEGEGMETTDTESV--- 1526
P T ++ + + ++ T + VTR +E + +T T SV
Sbjct: 1111 PATEFFGNTAEQTEPFLQQNRTK----QVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQ 1166
Query: 1527 ----SSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRET 1582
+ + +L NS ET+ E W + +L ++L D R +
Sbjct: 1167 EVKIEESEASVEGFSELENSEETRTES--WELKNQISQLQEQLMMLCADCD------RAS 1218
Query: 1583 EATNAILMEQIKLLKSEIRRLERNQE 1608
E +L + + +LK +++ LER E
Sbjct: 1219 EKKQDLLFD-VSVLKKKLKMLERIPE 1243
Score = 89.4 bits (220), Expect = 3e-17
Identities = 154/689 (22%), Positives = 266/689 (38%), Gaps = 127/689 (18%)
Query: 1022 LLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSN 1081
L LE E + + + +F+ I L ++ + E + SD L
Sbjct: 344 LALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSD----------LDKA 393
Query: 1082 AKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEH-ATTVNELEELQVQ-LQKEKKQLQ 1139
KL + EV A +++ E + +++ KE A NEL + + Q LQ+ KQ
Sbjct: 394 EKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRL 453
Query: 1140 KTMQELELVKKDA-----------------QQTTLMNME-IADYERLMKELNQKLTNK-N 1180
+ QE+E K + + L N E +A+YE L +L + L N
Sbjct: 454 ELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLA 513
Query: 1181 NKIEDLE--------QEIKIQKQKQE------TLQEEITSLQSSVQQYEEKNTKIKQLLV 1226
K DL+ QE ++ + + E LQ+++ LQS +++Y + ++ L
Sbjct: 514 EKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLK 573
Query: 1227 KTKKEL--ADSKQAETDHLI-------LQASLKGELEASQQQ-----------------V 1260
+ E A+S E +H + L S++ EL Q + V
Sbjct: 574 NSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKV 633
Query: 1261 EVYKIQLAEITSEKHKIHEHLKTSAEQHQRTL----SAYQQRVTALQEECRAAKAEQATV 1316
Y+ QL E K E++K E TL S + + LQ + K
Sbjct: 634 RHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEA 693
Query: 1317 TSEFESYKVRVHNVLKQQKN----KSMSQAETE----------GAKQEREHL------EM 1356
T E K ++ L+++K K Q E E ++ERE L E
Sbjct: 694 TCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEE 753
Query: 1357 LIDQLKIKLQDSQNNLQINVSELQTLQSEH--DTLLERHNKMLQETVSK-EAELREKLCS 1413
+ L +L+ ++ E TL+ E LLE+H + LQE K E E +
Sbjct: 754 KVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 813
Query: 1414 IQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLF 1473
I+++ +S+ + + S + L +R +++ LQE+ R+ E +
Sbjct: 814 IEAQ---FQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE------------EKSQW 858
Query: 1474 QLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYT 1533
+ + + T+ +Q+ LK +R T V +E E +E T E ++S
Sbjct: 859 EFEKDELTQECAEAQELLKETLKREKTT------SLVLTQEREMLEKTYKEHLNSMVVER 912
Query: 1534 QSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQI 1593
Q L Q L L + T++ L+ KS+ RE A EQ+
Sbjct: 913 QQLLQDLED--------LRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQL 964
Query: 1594 KLLKSEIRRLERNQEREKSAANLEYLKNV 1622
+ E +E +QER++ + L ++N+
Sbjct: 965 ASQRLERLEMEHDQERQEMMSKLLAMENI 993
>gi|148536871 ninein isoform 1 [Homo sapiens]
Length = 2046
Score = 206 bits (524), Expect = 2e-52
Identities = 371/1709 (21%), Positives = 711/1709 (41%), Gaps = 259/1709 (15%)
Query: 27 KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKA 86
+ DL K K + ++ + +E+ E + + E + I AL L +
Sbjct: 387 RSDLDKAEKLKSLMASEVDDHHAAIERR-NEYNLRKLDEEYKERIAALKNEL------RK 439
Query: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146
E EQ K+ ++++QE+E + T+ L S +KE L+NEL+ K +
Sbjct: 440 EREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS----LKENSRLENELLENAEKLA 495
Query: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
E + NL +L+ N + L+E+ + S +E + ++R +E Q LQ Q+D
Sbjct: 496 EYE-NLTNKLQR--NLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVD 552
Query: 207 ATTDEKKETVTQ-------LQNI----IEANSQHYQKNIN-----------SLQEELL-- 242
E +E Q L+N +EANS + S++ EL+
Sbjct: 553 ELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIE 612
Query: 243 QLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENL 302
Q+K H ++ L ++E + +E ++ + V C+ +++N+++++E E L
Sbjct: 613 QMKEQHHRDICCLRLELEDKVRHYEKQL-------DETVVSCKKAQENMKQRHENETHTL 665
Query: 303 RKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLK---ELESQHSILKDEVTYMN 359
K S+ N+I + Q E +H E+ + +LE + + L++++ +
Sbjct: 666 EKQISDLK--NEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQH 723
Query: 360 NLKLKLEMDAQHIKDEFFHEREDL------EFKINELL-----LAKEEQGCVIEKLKSEL 408
++LK + + F ERE L E K+ L +E+ ++EK E
Sbjct: 724 EMELKARL--TQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEK 781
Query: 409 AGLNKQFCYTVEQHNREVQSLKEQHQKE----ISELNETFLSDSEKEKLTLMFEIQGL-- 462
L K+ +E+H RE+Q +E+ + E S++ F SD +K +Q L
Sbjct: 782 EELRKEL---LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG 838
Query: 463 --KEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520
+++ ++LQ++++E +E ++ E+ Q E E+ + E++K+++ + + Q
Sbjct: 839 RYRQELKDLQEQQREEKSQWEFEKD--ELTQ-ECAEAQELLK---ETLKREKTTSLVLTQ 892
Query: 521 QK----------LRTAFTEKDALLETVNRLQGENE---KLLSQQELVPELENTIK-NLQE 566
++ L + E+ LL+ + L+ +E LLS Q L EL+++ K L+E
Sbjct: 893 EREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQIL--ELKSSHKRELRE 950
Query: 567 KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHK-KCEREERLIL 625
+ V + + + LE +E+ + ++KL M+N HK CE +R
Sbjct: 951 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLL----AMENIHKATCETADRERA 1006
Query: 626 ELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA 685
E+ ++ + L+ +KE Q L L +V+ E+ EV
Sbjct: 1007 EMSTEISR------------------LQSKIKEMQQATSPLSMLQSGCQVIGEE-EVEGD 1047
Query: 686 EVKSLYEENNKLSSEKKQLSRDLEVFLSQ--KEDVILKEHITQLEKKLQLMVEEQDNLNK 743
SL ++ +L E + L+ Q KE+V + I++L+++LQ + E +
Sbjct: 1048 GALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKL--EPGLVMS 1105
Query: 744 LLENEQVQKLFVKT--QLYGFLKEMGSEVSE--------DSEEKDVVNVLQAVGESLAKI 793
+E + F T Q FL++ ++ E E D V L + G S +
Sbjct: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQR 1165
Query: 794 NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE 853
E K + E ELE EE+ + ELK+ + +++ ++L + + +
Sbjct: 1166 QEVKIEESEASVEGFSELEN-----SEETRTESWELKNQISQLQEQLMMLCADCDRASEK 1220
Query: 854 KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913
K+ L D+ +K L +E + + K ++ E +E++ L+ L
Sbjct: 1221 KQDLLFDVSVLKKK-----------LKMLERIPEASPKYKLLYEDVS---RENDCLQEEL 1266
Query: 914 EQKELR---------DRRAELILLKDSLAKSPSVKNDPLSSVKELEE-KIENLEKE--CK 961
E R + AE+ L+D L K V LS K +E KIEN E
Sbjct: 1267 RMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVL 1326
Query: 962 EKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKD----QLSASMRDLIQGAE 1017
+ KI K++ V+ R + + LE+L E D QL+ ++ + +
Sbjct: 1327 RLQGKIEKLQESVVQ--------RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVR 1378
Query: 1018 SYKNLLLEYEKQSEQLD-----VEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLL 1072
S +++ E +++++ L+ +EK +A+ + +Q + I
Sbjct: 1379 SVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVI-------- 1430
Query: 1073 ARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQK-EQKIKEHATTVNELEELQVQL 1131
L+ N LL Q Q + + ELE KLQ+ +K+KE T + + +++
Sbjct: 1431 -----LEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHG 1485
Query: 1132 QKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIK 1191
+KE ++L+ M +L++ + QQ +E+ YE ++L Q+ + N+I L +E
Sbjct: 1486 EKE-EELKAMMHDLQITCSEMQQ----KVELLRYE--SEKLQQENSILRNEITTLNEEDS 1538
Query: 1192 IQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKG 1251
I K TL + + +++N +++++ KK++++ K + L
Sbjct: 1539 ISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQ 1598
Query: 1252 ELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKA 1311
+ +Q++++ +L E+ +K K E L +Q L+EE K
Sbjct: 1599 KNSQNQEKLQELNQRLTEMLCQKEK---------EPGNSALEEREQEKFNLKEELERCKV 1649
Query: 1312 EQATVTS--EFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQ 1369
+ +T+ S E E +V++ + QQ+N + K E E ++ L L D Q
Sbjct: 1650 QSSTLVSSLEAELSEVKIQTHIVQQENHLL--------KDELEKMKQL--HRCPDLSDFQ 1699
Query: 1370 NNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTV 1429
+ +S + L E + L E N + + ++K + L ++ +++ E + +
Sbjct: 1700 QKISSVLSYNEKLLKEKEALSEELNSCV-DKLAKSSLLEHRIATMKQEQKSWEHQSASLK 1758
Query: 1430 SQLTSQNEVLRN------SFRDQVRHLQEEHRKT---VETLQQQLSKMEAQLFQLKNEPT 1480
SQL + E ++N + Q+ ++ + R T E L+Q++ + QL +
Sbjct: 1759 SQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSW 1818
Query: 1481 TRSPVSSQQSLKNLRERRNTDLPLLDMHTVTRE------EGEGMET----TDTESVSSAS 1530
+ L N ++R + D LD H + E E E ++T T E S
Sbjct: 1819 APEIATHPSGLHNQQKRLSWD--KLD-HLMNEEQQLLWQENERLQTMVQNTKAELTHSRE 1875
Query: 1531 TYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQK---------LSSTTKSADHLNGLLRE 1581
Q LL + L P +E+L K S + +N L +E
Sbjct: 1876 KVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
Query: 1582 TEATNAILMEQIKLLKSEIRRLERNQERE 1610
E I +E L K +++ E+ E +
Sbjct: 1936 LE---TIHLENEGLKKKQVKLDEQLMEMQ 1961
Score = 191 bits (485), Expect = 5e-48
Identities = 327/1572 (20%), Positives = 676/1572 (43%), Gaps = 236/1572 (15%)
Query: 25 LPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSK------PVTEGTGDIIKA----- 73
L +E L + + + + + EL+ E+EE R++ P+ + ++A
Sbjct: 528 LQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGI 587
Query: 74 -------------LTERLDALLLEKAETEQQ-----CLSLKKENI--KMKQEVEDSVTKM 113
L ++A L+ + EQ CL L+ E+ +++++++V
Sbjct: 588 EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSC 647
Query: 114 GDAHKELEQSHINYV----KEIENLKNELMAVRS--------------KYSEDKANLQKQ 155
A + ++Q H N K+I +LKNE+ ++ ++ E+K LQ +
Sbjct: 648 KKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVK 707
Query: 156 LEEAMNTQLELSEQLKFQNNSE--DNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKK 213
LEE + L E+L+ Q+ E + + Q E+ R G + +K T + ++
Sbjct: 708 LEE---EKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ 764
Query: 214 ETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEIN-K 272
QL +++E ++ ++ L++ELL+ HQ E++E ++E ++I +
Sbjct: 765 FHQEQLTSLVEKHTLEKEE----LRKELLEK---HQRELQEGREKMETECNRRTSQIEAQ 817
Query: 273 LNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQI-CSILLQENTFVEQVVN 331
+ + ++CE++ ++++ +Y EL++L++ + L QE ++++
Sbjct: 818 FQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLK 877
Query: 332 EKVKHLEDTLKELESQHSILKDEVTYMNNL------KLKLEMDAQHIKDEFFHEREDLEF 385
E +K + T L + +L E TY +L + +L D + +++ ++ L
Sbjct: 878 ETLKREKTTSLVLTQEREML--EKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSD 935
Query: 386 KINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFL 445
+I EL + + + E++ + AG ++Q ++ ++ L+ +H +E E+ L
Sbjct: 936 QILELKSSHKRELREREEVLCQ-AGASEQLA------SQRLERLEMEHDQERQEMMSKLL 988
Query: 446 S----------DSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELG 495
+ +++E+ + EI L+ + + +QQ + + I E + G
Sbjct: 989 AMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE--EEVEG 1046
Query: 496 ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEK----LLSQQ 551
+ A + Q+ E + ++ + LQ+ A E + ++RLQ +K L+
Sbjct: 1047 DGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSS 1106
Query: 552 ELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEG--KINSLTEEKDDFINKL-KNSHE 608
L N E+ +L + K++EG + + L++ +DD + L
Sbjct: 1107 CLDEPATEFFGNTAEQTEPFL-----QQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTS 1161
Query: 609 EMDNFHKKCEREERLILELG--KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKL 666
+ K E E + + E+T + EL+ ++++L L + D+ +K
Sbjct: 1162 SVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKK 1221
Query: 667 EKLMVQMKVLSEDKEVL------SAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVIL 720
+ L+ + VL + ++L S + K LYE+ +S E L +L + ++ ++
Sbjct: 1222 QDLLFDVSVLKKKLKMLERIPEASPKYKLLYED---VSRENDCLQEELRMMETRYDEA-- 1276
Query: 721 KEHITQLEKKLQLMVEE---QDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEK 777
LE +L E QD L K+ E+V + F+ L++ EV ++EE
Sbjct: 1277 ------LENNKELTAEVFRLQDELKKM---EEVTETFLS------LEKSYDEVKIENEEL 1321
Query: 778 DVVNV-LQAVGESLAKINEEKC----------NLAFQRDEKVLELEKEIKCLQEESVVQC 826
+V+ + LQ E L + ++C NL + D +L+L + + EE V +
Sbjct: 1322 NVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTL----EECVPRV 1377
Query: 827 EELKSLLRDYEQEKVLLR---KELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVE 883
+ ++ + +QE L + LE++++ + A ++ E+ R++NQ +L
Sbjct: 1378 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQ--THQERPRVQNQVIL---- 1431
Query: 884 EVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQ--KELRDRRAELILLKDSLAKSPSVKND 941
E + T + + + + I E E K L++ ++L++R L+ KD L+
Sbjct: 1432 EENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHG------ 1485
Query: 942 PLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSE 1001
+EL+ + +L+ C E ++K+ ++ + K ++E R E T+ EE +
Sbjct: 1486 --EKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLK 1543
Query: 1002 KDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQC 1061
L+ S ++ Q E+ K E + Q VE + E +I++ L N+ L
Sbjct: 1544 LGTLNGSQEEMWQKTETVKQ-----ENAAVQKMVENLKKQISELKIKNQQLDLENTELSQ 1598
Query: 1062 ETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTV 1121
+ NS N++ L + N +L E+ + KE E E++ +E
Sbjct: 1599 K--NSQNQEKLQEL-----NQRLTEM----------LCQKEKEPGNSALEEREQEKFNLK 1641
Query: 1122 NELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNN 1181
ELE +VQ L+ + E+++ QQ N + D MK+L ++
Sbjct: 1642 EELERCKVQSSTLVSSLEAELSEVKIQTHIVQQE---NHLLKDELEKMKQL-----HRCP 1693
Query: 1182 KIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETD 1241
+ D +Q+I E L +E +L + +K K L + +A KQ +
Sbjct: 1694 DLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLL----EHRIATMKQEQKS 1749
Query: 1242 HLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTA 1301
ASLK +L ASQ++V+ + + + + ++ L+ + ++ + A +Q V +
Sbjct: 1750 WEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKE----ALKQEVMS 1805
Query: 1302 LQEECRAAKAEQATVTSEFESYKVRVHNVLKQ---QKNKSMSQAETEGAKQEREHLEMLI 1358
L ++ + A + + E ++ +HN K+ K + E + QE E L+ ++
Sbjct: 1806 LHKQLQNAGGK--SWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMV 1863
Query: 1359 DQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSEN 1418
K +L S+ V +L++ LL +H K L + + +EKL S++ E
Sbjct: 1864 QNTKAELTHSRE----KVRQLES------NLLPKHQKHLNPSGTMNPTEQEKL-SLKREC 1912
Query: 1419 MMMKSEHT---QTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQL 1475
+ E + + VSQ+ S + L + HL+ E L+++ K++ QL ++
Sbjct: 1913 DQFQKEQSPANRKVSQMNSLEQEL------ETIHLEN------EGLKKKQVKLDEQLMEM 1960
Query: 1476 KNEPTTRSPVSS 1487
++ +T +P S
Sbjct: 1961 QHLRSTATPSPS 1972
Score = 125 bits (315), Expect = 3e-28
Identities = 299/1516 (19%), Positives = 636/1516 (41%), Gaps = 229/1516 (15%)
Query: 334 VKHLEDTLKE--LESQHSILK------DEVTYMNNLKLKLEMDAQHIKDE--------FF 377
V+ + DT +E +E+ ILK D + L L LE + K+ F
Sbjct: 307 VERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFK 366
Query: 378 HEREDLEFKINELLLAKEEQGCVI---EKLKSELAGLNKQFCYTVEQHNR-EVQSLKEQH 433
E L ++++++ KE+ + EKLKS +A +E+ N ++ L E++
Sbjct: 367 AEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEY 426
Query: 434 QKEISELN-------ETFLSDSEKEKLTLMFEIQ---------------GLKE--QCENL 469
++ I+ L E L + K++L L EI+ LKE + EN
Sbjct: 427 KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 486
Query: 470 QQEKQEAILNYESL-REIMEILQTELGESAGKI---SQEFESMKQQQASDVHELQQKLRT 525
E E + YE+L ++ L+ L E G + S EF +++ +E +++ R
Sbjct: 487 LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRV 546
Query: 526 AFTEKDALLETVN--RLQGENEKLLSQQELVPELENTIKNLQEKNGV------------- 570
+ D L + R QG +L + E+E ++ ++G+
Sbjct: 547 LQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 606
Query: 571 ------YLLSLSQRDT--MLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHK-KCEREE 621
+ RD + ELE K+ ++ D+ + K + E M H+ + E
Sbjct: 607 AELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLE 666
Query: 622 RLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKE-----KDQNDQKLEKLMVQMKVL 676
+ I +L ++ + + L++ +E T EE K+ +++ EKL +Q ++
Sbjct: 667 KQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEM- 725
Query: 677 SEDKEVLSAEVKSLYEENNKLSSEK------KQLSRDLEVFLSQKEDVILKEHITQLEK- 729
E K L+ S E L S + L+++LE F ++ ++++H + E+
Sbjct: 726 -ELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEEL 784
Query: 730 KLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSE---EKDVVNVLQAV 786
+ +L+ + Q L + E + + +Q+ + +V+E E + Q +
Sbjct: 785 RKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQEL 844
Query: 787 GESLAKINEEKCNLAFQRDEKVLE-------LEKEIKCLQEESVVQCEELKSLLRDYEQ- 838
+ + EEK F++DE E L++ +K + S+V +E + L + Y++
Sbjct: 845 KDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEH 904
Query: 839 ------EKVLLRKELEEIQSEKEALQS----DLLEMKNANEKTRLENQNLLIQVEEVSQT 888
E+ L ++LE++++ E QS +LE+K+++++ E + +L Q Q
Sbjct: 905 LNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQL 964
Query: 889 CSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKE 948
S+ E E H+ E++E+ + +L +++ K+ D + E
Sbjct: 965 ASQRLERLEME------HDQ-----ERQEMMSK----LLAMENIHKATCETADRERA--E 1007
Query: 949 LEEKIENLEKECKEKEEKINKIKLVA----------VKAKKELDSSRKETQTVKEELESL 998
+ +I L+ + KE ++ + + ++ V+ L ++ Q ++E + L
Sbjct: 1008 MSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVL 1067
Query: 999 RSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEK---ERANNFEHRIEDLTRQL- 1054
S + ++++ ++ A L +K L + E A F + T
Sbjct: 1068 LSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFL 1127
Query: 1055 -RNSTLQCETIN-----SDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKL 1108
+N T Q E + SD ED R + + ++ Q ++++ ++A V+ E E
Sbjct: 1128 QQNRTKQVEGVTRRHVLSDLEDDEVR-DLGSTGTSSVQRQEVKIEESEASVEGFSELEN- 1185
Query: 1109 QKEQKIKEHATTVNELEELQVQLQ---------KEKKQ--------LQKTMQELELVKKD 1151
E+ E N++ +LQ QL EKKQ L+K ++ LE + +
Sbjct: 1186 -SEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEA 1244
Query: 1152 AQQTTLMNMEIA-DYERLMKELNQKLTNKNNKIEDLEQ------EIKIQKQKQETLQEEI 1204
+ + L+ +++ + + L +EL T + +E+ ++ ++ + +K E + E
Sbjct: 1245 SPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETF 1304
Query: 1205 TSLQSSVQQYEEKNTKIKQLLVKTK---KELADSKQAETDHLILQASLKG-ELEASQQQV 1260
SL+ S + + +N ++ L+++ + ++L +S D + +ASL+ E+E +
Sbjct: 1305 LSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNIL 1364
Query: 1261 EVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEF 1320
++ + L E +H ++ +++Q Y + T L E+ +A + T +
Sbjct: 1365 QLNQT-LEECVPRVRSVHHVIEECKQENQ-----YLEGNTQLLEKVKAHEIAWLHGTIQT 1418
Query: 1321 ESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQ 1380
+ RV N + ++N ++ + + + + E+ ++ K KLQ+ L+ V+ L
Sbjct: 1419 HQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELE--KTKLQELTRKLKERVTILV 1476
Query: 1381 TLQS--EHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEV 1438
+ H E M+ + +E+++K+ ++ E+ ++ E++ +++T+ NE
Sbjct: 1477 KQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE 1536
Query: 1439 --LRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLR- 1495
+ N + QEE + ET++Q+ + ++ + LK + S+ +KN +
Sbjct: 1537 DSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQ-------ISELKIKNQQL 1589
Query: 1496 ERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAE 1555
+ NT+L +++ + E + Q ++ NS + E ++
Sbjct: 1590 DLENTEL--------SQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNL- 1640
Query: 1556 FTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLER-------NQE 1608
KEEL + ++ L L E + I+ ++ LLK E+ ++++ +
Sbjct: 1641 --KEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDF 1698
Query: 1609 REKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENAS 1668
++K ++ L Y + +L E+E L +N+ + KLA + E A+
Sbjct: 1699 QQKISSVLSYNEKLL---------KEKEALSEELNSCVD-------KLAKSSLLEHRIAT 1742
Query: 1669 RSSGWASYLHSWSGLR 1684
S+ H + L+
Sbjct: 1743 MKQEQKSWEHQSASLK 1758
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 202 bits (515), Expect = 2e-51
Identities = 356/1633 (21%), Positives = 687/1633 (42%), Gaps = 203/1633 (12%)
Query: 84 EKAETEQQCLSLK--KENIKMKQEVEDSVTKMGDAHKE----LEQSHINYVKEIENLKNE 137
E + E +CL L+ E + +QE + + ++ A +E LEQ + KE+ L+ +
Sbjct: 802 EVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREK 861
Query: 138 LMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQ 197
RS + ++ L K LE ++EL +LK Q + ++ +Q + E+ R E
Sbjct: 862 WEKERSWHQQE---LAKALESLEREKMELEMRLKEQ---QTEMEAIQAQREEERTQAESA 915
Query: 198 ILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQK-----NINSLQEELLQLKAIHQEEV 252
+ +Q + + ET+ Q Q + SQ ++ + L+E+ + I Q ++
Sbjct: 916 LCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQ--ETTGILQTQL 973
Query: 253 KELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQD 312
+E +++ +A++H ++ L E +L++ + ++QK ++E+L K+ A D
Sbjct: 974 QEAQRELKEAARQHRDDLAALQEESSSLLQD----KMDLQK----QVEDL-KSQLVAQDD 1024
Query: 313 NQICSILLQENTFVEQVVNEKVKHLED---TLKELESQHSILKDEVTYMNNLKLKLEMDA 369
+Q VEQ V EK++ ++ KELE + + L + L L+
Sbjct: 1025 SQ---------RLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEAD 1075
Query: 370 QHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSL 429
+ E R+D++ E ++E +E L+ E+ F +E Q L
Sbjct: 1076 SIRQQELSALRQDMQEAQGE----QKELSAQMELLRQEVKEKEADFLA------QEAQLL 1125
Query: 430 KEQHQKEISELN-ETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEA--ILNYESLREI 486
+E I+E L E + L ++ + Q E L E+Q L +
Sbjct: 1126 EELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASL 1185
Query: 487 MEILQTELG---ESAGKISQEFESMK---------------------------QQQASDV 516
LQ LG ES ++S +S + AS +
Sbjct: 1186 YSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASAL 1245
Query: 517 HELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLS 576
H+L Q L +D L + V +L+ E+L + ++ +++LQ + LS
Sbjct: 1246 HKLHQDLWKTQQTRDVLRDQVQKLE---ERLTDTEAEKSQVHTELQDLQRQ-------LS 1295
Query: 577 QRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQ 636
Q + EGK NSL E L HE M + + R E +E + E
Sbjct: 1296 QNQEEKSKWEGKQNSLESE-------LMELHETMASLQSRLRRAELQRMEAQGERELLQA 1348
Query: 637 YNSELEQKVNELTGGLEETLKEKDQN---DQKLEKLMVQMKVLSEDKEVLSAEVKSLYEE 693
L +V L + E + ++ L +K+ +E+ E ++L E+
Sbjct: 1349 AKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQ 1408
Query: 694 NNKLSSEKKQLSRDLEVF---LSQKEDVI--LKEHITQLEKKLQLMVE---------EQD 739
++ K L +L + L+++E+ + L+ I +LEK+ ++ ++
Sbjct: 1409 GELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKR 1468
Query: 740 NLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCN 799
N L+ EQ+Q+L + L+ + V E ++ V E + ++ +++
Sbjct: 1469 NQEVDLQQEQIQEL---EKCRSVLEHLPMAVQEREQKLTVQR------EQIRELEKDRET 1519
Query: 800 LAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQS 859
+ ++LELEK+ + ++ + Q ++LK L E L ELEE + E Q
Sbjct: 1520 QRNVLEHQLLELEKKDQMIESQRG-QVQDLKKQLVTLE----CLALELEENHHKMECQQK 1574
Query: 860 DLLEMKNANEKTRLENQNLLIQVEEVSQT--CSKSEIHNEKEKCFIKEHENLKPLLEQKE 917
+ E++ E R+ +L + +EE SQ S+IH+ + + E + E K
Sbjct: 1575 LIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKS 1634
Query: 918 LRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLE-KECKEKEEKINKIKLVAVK 976
R++ EL K+ L + ++ L KE + +E+ ++ K EE + +IKL +
Sbjct: 1635 QREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRE 1694
Query: 977 AKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVE 1036
+EL + R+ Q EE + + M+ +++ E E E Q E +
Sbjct: 1695 RGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEK------EVECQQEHIHEL 1748
Query: 1037 KERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKL----LEVQILEV 1092
+E + E +++ L R++ ++L + L +++ + +L L+ Q+ E
Sbjct: 1749 QELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEA 1808
Query: 1093 QRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDA 1152
QRA A D+ELEA + +++Q + + + LQ L++ L++ EL+ K+ A
Sbjct: 1809 QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQA 1868
Query: 1153 QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQE---IKIQKQKQETLQE---EITS 1206
++ + E+A R ++ L + L + + E EQE + +Q+Q E QE E +
Sbjct: 1869 RR---LEEELAVEGRRVQALEEVLGDL--RAESREQEKALLALQQQCAEQAQEHEVETRA 1923
Query: 1207 LQSSVQQYE----EKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEV 1262
LQ S Q + E++ +++ L +++ + A LQ +L G+ A+ Q E
Sbjct: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEAL-GKAHAALQGKEQ 1982
Query: 1263 YKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFES 1322
+ ++ AE++ L+ S Q +L A Q L+E R + E + +
Sbjct: 1983 HLLEQAELSRS-------LEASTATLQASLDACQAHSRQLEEALRIQEGE---IQDQDLR 2032
Query: 1323 YKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTL 1382
Y+ V QQ ++++Q + E + ++E ++L L ++Q++ + N+ Q
Sbjct: 2033 YQEDV-----QQLQQALAQRDEE-LRHQQEREQLLEKSLAQRVQENMIQEKQNLG--QER 2084
Query: 1383 QSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNS 1442
+ E L + + LQ T++++ + +L Q N + H+ S + Q+ L +
Sbjct: 2085 EEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDS- 2143
Query: 1443 FRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPT--------TRSPVSSQQSLK-- 1492
L+ ++ +E LQ L + EA+ + + + T++ VSS Q +
Sbjct: 2144 -------LEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196
Query: 1493 ---NLRERRNTDLPLLDMHTVTRE--EGEGMETTDTESVSSASTYTQSLEQLLNSPETKL 1547
++ ER + L D +TR E E + + S + + + QL +
Sbjct: 2197 LQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEA 2256
Query: 1548 EPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQ 1607
EP E K+ Q+L ++ L + N L ++ ++ E R+L+R
Sbjct: 2257 EPSPDGME--KQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREA 2314
Query: 1608 EREKSAANLEYLK 1620
R A +LE K
Sbjct: 2315 MRAAQAGSLEISK 2327
Score = 197 bits (501), Expect = 7e-50
Identities = 346/1713 (20%), Positives = 706/1713 (41%), Gaps = 207/1713 (12%)
Query: 28 EDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAE 87
++LI+ + + + + R TEL + + S+ E +IKAL E ++ L E
Sbjct: 265 QELIQLKSQGDLEKAELQDRVTELSALLTQ--SQKQNEDYEKMIKALRETVEILETNHTE 322
Query: 88 TEQQCLSLKK----ENIKMKQEVEDSVTKM---------GDAHK---ELEQSHINYVKEI 131
+ SL + E + ++Q ++D M G H+ EL+ S + +
Sbjct: 323 LMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQF-DY 381
Query: 132 ENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKI- 190
++ L VRS + + +Q ++ Q ++ + + E+ K L++ ++K+
Sbjct: 382 QDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLT 441
Query: 191 --RPGFEEQILYLQKQLDATTDEK------KETVTQLQNIIEANSQHYQKNINSLQ---- 238
R Q + LQ ++D+ + E+ +E + Q ++E + ++ LQ
Sbjct: 442 GERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGD 501
Query: 239 ---------EELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNE------LKENLVKQ 283
+E L L +E ++E++ +EA E +E+ L E L+ L++Q
Sbjct: 502 SAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQ 561
Query: 284 CEASEKNIQKKYECELENLRKATSNANQD-NQICSILLQENTFVEQVVNEKVKHLEDTLK 342
+ + E + L + + + + + ++ + E + +KV L L
Sbjct: 562 EQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKV-GLNQQLL 620
Query: 343 ELESQHSILKDEVTYMNNLKLKLEMD---AQHIKDEFFHEREDLEFKINELLLAKEEQGC 399
+LE ++ + + + L++D A+ ++ + + LE ++ + A E
Sbjct: 621 QLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQA 680
Query: 400 VIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEI 459
+ ++ E + K+ + Q L++ HQ+ ++ E L+ + +EK L+ E
Sbjct: 681 DLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQE--AKRQEEVLARAVQEKEALVREK 738
Query: 460 QGLKEQCENLQQEKQEAILNYESLREIMEILQTELGE----------SAGKISQEFESMK 509
L+ + + +++++Q+ + L E+L++ L E + G++ + +++
Sbjct: 739 AALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
Query: 510 QQQ---ASDVHELQQKLRT----AFTEKDALLETVNRLQGENEKLLSQQELVPELE-NTI 561
Q + +V L+ +L T A E+DA + + + E + L QQ+ E E N +
Sbjct: 799 QAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQL 858
Query: 562 KNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREE 621
+ EK +R +EL + SL EK + +LK EM+ + +REE
Sbjct: 859 REKWEK---------ERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI--QAQREE 907
Query: 622 RLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLS-EDK 680
E + Q E E++ L L +T KE Q+LE+L MKV +++
Sbjct: 908 ----ERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQ 963
Query: 681 EVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDN 740
E L E +L +Q DL + +E + L+ K+ L + +D
Sbjct: 964 ETTGILQTQLQEAQRELKEAARQHRDDLA--------ALQEESSSLLQDKMDLQKQVEDL 1015
Query: 741 LNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNL 800
++L+ + Q+L + EV E E N +Q ++ EK +L
Sbjct: 1016 KSQLVAQDDSQRL------------VEQEVQEKLRETQEYNRIQ------KELEREKASL 1057
Query: 801 AFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQ----------EKVLLRKELEEI 850
++E E+ + LQE ++ +EL +L +D ++ + LLR+E++E
Sbjct: 1058 TL----SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEK 1113
Query: 851 QSEKEALQSDLLEMKNANEKTRLE-NQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENL 909
+++ A ++ LLE A+ T + +L Q + +Q + + + E +
Sbjct: 1114 EADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPG 1173
Query: 910 KPLLEQKELRDRRAELILLKDSLAKSP---SVKNDPLSSVKELEEKIENLEKECKEKEEK 966
Q +L + L S+ +S S D SV LE +N + ++
Sbjct: 1174 NQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPD-QNGARSLFKRGPL 1232
Query: 967 INKIKLVAV------------KAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQ 1014
+ + AV K ++ D R + Q ++E L +EK Q+ ++DL +
Sbjct: 1233 LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQR 1292
Query: 1015 GAESYKNLLLEYEKQSEQLDVE----KERANNFEHRIEDLTRQLRNSTLQCETINSDNED 1070
+ ++E + L+ E E + + R+ Q + + E + + E+
Sbjct: 1293 QLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKEN 1352
Query: 1071 LLARIETLQ----------SNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATT 1120
L A++E LQ S A +LE + + A + ++E+E+E+ + + ++
Sbjct: 1353 LTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELK 1412
Query: 1121 VNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLM-NMEIADYERLMKELNQKLTNK 1179
V + + LQ L + L + +E+E ++ Q+ M+ A E L +L K
Sbjct: 1413 VAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDL-----KK 1467
Query: 1180 NNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAE 1239
N+ DL+QE Q Q+ E + + L +VQ+ E+K T ++ + + +K+ ++++
Sbjct: 1468 RNQEVDLQQE---QIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKD-RETQRNV 1523
Query: 1240 TDHLILQASLKGELEASQQ-QVEVYKIQLA-------EITSEKHKI--HEHLKTSAEQHQ 1289
+H +L+ K ++ SQ+ QV+ K QL E+ HK+ + L E +
Sbjct: 1524 LEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQR 1583
Query: 1290 RTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAE-TEGAK 1348
T +T EE Q++ + ES+ + L+++ + SQ E E +
Sbjct: 1584 ETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQ 1643
Query: 1349 QEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSK-EAEL 1407
+++EHL L+ L + +Q L+ + R K+L+E + + + L
Sbjct: 1644 RQKEHLTQ-------DLERRDQELMLQKERIQVLEDQR----TRQTKILEEDLEQIKLSL 1692
Query: 1408 REKLCSIQSENMMMKSEHTQTVSQLTSQN---EVLRNSFRDQVRHL--QEEHRKTVETLQ 1462
RE+ + ++ +M+ + +Q E ++ RD+ + + Q+EH ++ L+
Sbjct: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELK 1752
Query: 1463 QQLSKMEAQLFQLKNEPT------TRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGE 1516
QL + L + E + + V QQ L+ RE+ L +
Sbjct: 1753 DQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRAL 1812
Query: 1517 GMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLN 1576
+ E++ Q E+ + L+ L A T +E +L + A
Sbjct: 1813 AQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARR-- 1870
Query: 1577 GLLRETEATNAILMEQIKLLKSEIRRLERNQER 1609
L E A ++ ++ + ++R R QE+
Sbjct: 1871 --LEEELAVEGRRVQALEEVLGDLRAESREQEK 1901
Score = 189 bits (479), Expect = 3e-47
Identities = 352/1814 (19%), Positives = 753/1814 (41%), Gaps = 237/1814 (13%)
Query: 35 KKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLS 94
+K + + +S C ELEK +E P+ + ++ + LD LL+ E +Q+C S
Sbjct: 57 RKLQAKVLQYRSWCQELEKRLEATGG-PIPQRWENVEEP---NLDELLVRLEEEQQRCES 112
Query: 95 LKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQK 154
L + N +++ +E K +K L + + ++ELM S++ ++ +
Sbjct: 113 LAEVNTQLRLHME----KADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKG 168
Query: 155 QLEEAMNTQLELSEQ--------LKFQNNSEDNVKKLQEEIEKIRPGFEEQILYL----- 201
L+ L L + L+ ++ ++ ++ +L+ E ++ L L
Sbjct: 169 YLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQ 228
Query: 202 QKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQL-------KAIHQEEVKE 254
++ + + QL ++ A +Q +K + +EL+QL KA Q+ V E
Sbjct: 229 SREPNGSGRMDGREPAQLLLLL-AKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTE 287
Query: 255 LMCQIEASAKEHEAEINKLNELKENL---------VKQCEAS---------------EKN 290
L + S K++E + L+E + + + EAS K+
Sbjct: 288 LSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKD 347
Query: 291 IQKKYECELENLRKATSNANQDNQICSILLQEN--------TFVEQVVNEKVKHLEDTLK 342
I + E +N+ + + + N SI Q + T V V+ + + ++D +
Sbjct: 348 ITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQ 407
Query: 343 E----------LESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLL 392
+ L+ QH ++E + KL + +D + DL+ +++ L
Sbjct: 408 QLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGE----RDTLAGQTVDLQGEVDSLSK 463
Query: 393 AKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKE--QHQKEISELNETFLSDSEK 450
+E E+L+ +L L +Q + + + N E+Q + Q QKE + E L+ E+
Sbjct: 464 ERELLQKAREELRQQLEVL-EQEAWRLRRVNVELQLQGDSAQGQKE-EQQEELHLAVRER 521
Query: 451 EKLTLMFEIQGLK-EQCENLQQ--EKQEAILNYESLREIMEILQTELGESAGKISQEF-- 505
E+L M + GL+ +Q E+L + +EA+ + E++ QTE+ + + Q
Sbjct: 522 ERLQEM--LMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAE 579
Query: 506 ----ESMKQQQASDVHELQQKL----RTAFTEKDALLETVNRLQGENEKLLSQQELVPEL 557
E+ + + +D+ KL +K L + + +L+ EN+ + S+ E +
Sbjct: 580 LSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQA 639
Query: 558 ENTI-----------KNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNS 606
N + + L EKN L + + EL+ + + EEK++ KL S
Sbjct: 640 RNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSES 699
Query: 607 HE-------EMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEK 659
+++ H++ +R+E ++ ++ E ++ + LE ++ + E+
Sbjct: 700 RHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAV---------ER 750
Query: 660 DQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVI 719
D+ D L Q++ LS KE+L + + ++N+ + K QL ++ KE +
Sbjct: 751 DRQD-----LAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ 805
Query: 720 LKEHITQLEKKLQLMVEEQDN---LNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEE 776
+ +LE + EQ+ +L + EQ K ++ Q KE+ + E
Sbjct: 806 GEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQ--LREKWE 863
Query: 777 KDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEE-LKSLLRD 835
K+ Q + ++L + EK L + E+ E+E I+ +EE Q E L + +
Sbjct: 864 KERSWHQQELAKALESLEREKMELEMRLKEQQTEME-AIQAQREEERTQAESALCQMQLE 922
Query: 836 YEQEKVLL-------RKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQT 888
E+E+V L +KEL + + E L+ D+ K ++T L Q++E +
Sbjct: 923 TEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQET---TGILQTQLQEAQRE 979
Query: 889 CSKSEIHNEKEKCFIKEHEN--LKPLLE-QKELRDRRAELILLKDSLAKSPSVKNDPLSS 945
++ + + ++E + L+ ++ QK++ D +++L+ DS + L
Sbjct: 980 LKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039
Query: 946 V-------KELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESL 998
KELE + +L EKE+++ ++ ++EL + R++ Q + E + L
Sbjct: 1040 TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKEL 1099
Query: 999 RSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNF--EHRIEDLTRQLRN 1056
++ + L +++ + + LLE E ++ + ++ RA+ + E + L +LR+
Sbjct: 1100 SAQMELLRQEVKEKEADFLAQEAQLLE-ELEASHITEQQLRASLWAQEAKAAQLQLRLRS 1158
Query: 1057 STLQCETINSDNE-----DLLARIETLQSNAKLLEVQILEVQ-RAKAMVDKELEAEKLQK 1110
+ Q E + ++ + A++ +L S + + E + D L+
Sbjct: 1159 TESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEP 1218
Query: 1111 EQK------IKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIAD 1164
+Q + T E + L K + L KT Q ++++ Q+ + + D
Sbjct: 1219 DQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQK---LEERLTD 1275
Query: 1165 YERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEE--KNTKIK 1222
E +++ +L + ++ ++E + KQ +L+ E+ L ++ + + +++
Sbjct: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335
Query: 1223 QLLVKTKKELADSKQ----AETDHL-------ILQASLKGELEASQQQV-EVYKIQLAEI 1270
++ + ++EL + + A+ +HL QAS G LE + K++ E+
Sbjct: 1336 RMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEV 1395
Query: 1271 TSEKHKIH------EHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYK 1324
SE+ + E + Q L+ Q + +EE + + + + E K
Sbjct: 1396 ESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQK 1455
Query: 1325 VRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQS 1384
+ + K ++ + QE E +++ L + +Q+ + L + +++ L+
Sbjct: 1456 AALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEK 1515
Query: 1385 EHDTL----------LERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQ--L 1432
+ +T LE+ ++M++ + +L+++L +++ + ++ H + Q L
Sbjct: 1516 DRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKL 1575
Query: 1433 TSQNEVLRNSFRDQVRHLQ---EEHRKTVETLQQQLSKMEAQLFQLKNEPTTR-SPVSSQ 1488
+ E R + R + HL EE + ++ Q+ +E+ L E R V SQ
Sbjct: 1576 IKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQ 1635
Query: 1489 ----QSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPE 1544
+ L+ +E DL D + ++ E ++ + + + LEQ+ S
Sbjct: 1636 REQIEELQRQKEHLTQDLERRDQELMLQK--ERIQVLEDQRTRQTKILEEDLEQIKLSLR 1693
Query: 1545 TKLEPPLWHAEFTKEELVQKLSSTTK--------SADHLNGLLRETEATNAILMEQIKLL 1596
+ T+ +L+Q+ + K S +H+ +LR+ E E I
Sbjct: 1694 ER-----GRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHI--- 1745
Query: 1597 KSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKL 1656
E++ L+ E++ + + + LL S+RE+ + V+ LQ + E+
Sbjct: 1746 -HELQELKDQLEQQLQGLHRKVGETSLLL-------SQREQEIVVLQQQLQEAREQGELK 1797
Query: 1657 AAVAQGEEENASRS 1670
Q + + A R+
Sbjct: 1798 EQSLQSQLDEAQRA 1811
Score = 187 bits (476), Expect = 6e-47
Identities = 322/1567 (20%), Positives = 665/1567 (42%), Gaps = 248/1567 (15%)
Query: 36 KQMMLIQKAKSRCTE--LEKEIEELRS--KPVTEGTGDIIKALTERLDALLLEKAETEQQ 91
+Q M +QK K + T L+ +++E + K D + AL E +LL +K + ++Q
Sbjct: 952 RQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQ 1011
Query: 92 CLSLKKENIK-------MKQEVEDSVTKMGDAH---KELEQSHINYVKEIENLKNELMAV 141
LK + + ++QEV++ + + + + KELE+ + + + L+ +
Sbjct: 1012 VEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVL 1071
Query: 142 RSKYS---EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQI 198
+ S ++ + L++ ++EA Q ELS Q++ L++E+++ F Q
Sbjct: 1072 QEADSIRQQELSALRQDMQEAQGEQKELSAQMEL----------LRQEVKEKEADFLAQE 1121
Query: 199 LYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQE-EVKELMC 257
L ++L+A+ +++ L EA + Q + S + +L L A Q +
Sbjct: 1122 AQLLEELEASHITEQQLRASLW-AQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQA 1180
Query: 258 QIEASAKEHEAEINKLNELKENL---------VKQCEASEKNIQKKYE-------CELEN 301
Q+ + + + + E + L V E + + ++ E
Sbjct: 1181 QLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEA 1240
Query: 302 LRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNL 361
+ A +QD L + V+ ++V+ LE+ L + E++ S + E + +L
Sbjct: 1241 VASALHKLHQD-------LWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTE---LQDL 1290
Query: 362 KLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLK-SELAGLNKQFCYTVE 420
+ +L + Q K ++ ++ LE ++ EL E + +L+ +EL + Q +
Sbjct: 1291 QRQLSQN-QEEKSKWEGKQNSLESELMEL---HETMASLQSRLRRAELQRMEAQGERELL 1346
Query: 421 QHNREVQSLKEQH----------QKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQ 470
Q +E + + +H Q + + E L + E++ +E+ + LQ
Sbjct: 1347 QAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQ 1406
Query: 471 QEKQEAILNYESLREIMEILQTELGESAGKIS------QEFESMKQQQASDVHELQQKLR 524
++ + + ++L+E + +L L E ++ QE E ++ Q + + L L+
Sbjct: 1407 EQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK 1466
Query: 525 TAFTEKDALLETVNRL--------------QGENEKLLSQQELVPELENTIKNLQEKNGV 570
E D E + L Q +KL Q+E + ELE + +
Sbjct: 1467 KRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEH 1526
Query: 571 YLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILEL-GK 629
LL L ++D M++ G++ L ++ + L+ E++ H K E +++LI EL G+
Sbjct: 1527 QLLELEKKDQMIESQRGQVQDLKKQ----LVTLECLALELEENHHKMECQQKLIKELEGQ 1582
Query: 630 KVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKS 689
+ Q + + LT LEE +E ++ L VL+ + + EVKS
Sbjct: 1583 RETQRVA--------LTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKS 1634
Query: 690 LYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQ 749
E+ +L +K+ L++DLE + ++++L+ ++++Q++ +++ K+LE +
Sbjct: 1635 QREQIEELQRQKEHLTQDLE---RRDQELMLQ------KERIQVLEDQRTRQTKILEEDL 1685
Query: 750 VQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVL 809
Q +K L+E G E++ + + G S A+ + RD+
Sbjct: 1686 EQ---IKLS----LRERGRELTTQRQLMQ-ERAEEGKGPSKAQRGSLEHMKLILRDK--- 1734
Query: 810 ELEKEIKCLQEESVVQCEELKS------------------LLRDYEQEKVLLRKELEEIQ 851
EKE++C Q+E + + +ELK LL EQE V+L+++L+E +
Sbjct: 1735 --EKEVEC-QQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAR 1791
Query: 852 SE----KEALQSDLLEMKNA-------NEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEK 900
+ +++LQS L E + A E + E Q Q E V + + E+
Sbjct: 1792 EQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAH 1851
Query: 901 CFIKEH--------ENLKPLLEQKELRDRRAELI--LLKDSLAKSPSVKNDPLSSVKELE 950
+KE E + L E+ + RR + + +L D A+S + L+ ++
Sbjct: 1852 MTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCA 1911
Query: 951 EKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMR 1010
E+ + E E + ++ + + V + +EL++ R E+Q+ + + E+ R+ + L ++
Sbjct: 1912 EQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALG 1971
Query: 1011 DLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNED 1070
+ + LLE + S L+ T L+ S C+ + E+
Sbjct: 1972 KAHAALQGKEQHLLEQAELSRSLEAS--------------TATLQASLDACQAHSRQLEE 2017
Query: 1071 LLARIE--TLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQ 1128
L RI+ +Q + + ++Q+A A D+EL + Q+ +E + + +Q
Sbjct: 2018 AL-RIQEGEIQDQDLRYQEDVQQLQQALAQRDEEL------RHQQEREQLLEKSLAQRVQ 2070
Query: 1129 VQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQ 1188
+ +EK+ L + +E E ++ Q + + +A E+ + EL + T + N +E L
Sbjct: 2071 ENMIQEKQNLGQEREE-EEIRGLHQSVRELQLTLAQKEQEILELRE--TQQRNNLEALPH 2127
Query: 1189 EIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQAS 1248
K ++++L ++ SL+ +Q+ E +++ L +T+ + ++ D + A
Sbjct: 2128 SHKTSPMEEQSL--KLDSLEPRLQRELE---RLQAALRQTEAREIEWREKAQDLALSLAQ 2182
Query: 1249 LKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRA 1308
K + + Q+ + + E SE+ ++ + L+ + AL++E
Sbjct: 2183 TKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRR--------------ALEKE--R 2226
Query: 1309 AKAEQATVTSEFES---YKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKL 1365
+ AT T+E S V++ V + S E + +Q EHL+ + +L+I
Sbjct: 2227 LHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEI-- 2284
Query: 1366 QDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEH 1425
+ L+RHN L+ T+ + R KL + E M
Sbjct: 2285 --------------------DRSRLQRHNVQLRSTLEQVERERRKL---KREAMRAAQAG 2321
Query: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLF---QLKNEPTTR 1482
+ +S+ T+ + ++ R + K V LQ+++ ++AQL + K + TR
Sbjct: 2322 SLEISKATASSPTQQDG-----RGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITR 2376
Query: 1483 SPVSSQQ 1489
S +S++
Sbjct: 2377 SAQTSRE 2383
Score = 153 bits (387), Expect = 1e-36
Identities = 306/1520 (20%), Positives = 597/1520 (39%), Gaps = 282/1520 (18%)
Query: 195 EEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKE 254
EEQ+L LQ+Q+ + + + +L+N EA Q + LQ ++LQ ++ QE
Sbjct: 21 EEQVLALQQQM---AENQAASWRKLKNSQEAQ-QRQATLVRKLQAKVLQYRSWCQE---- 72
Query: 255 LMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYE-CELENLRKATSNANQDN 313
L K+ EA+ I +++E E NL + ++
Sbjct: 73 -------------------------LEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQ 107
Query: 314 QICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIK 373
Q C L + NT L +++ + + L+++V KL +D +
Sbjct: 108 QRCESLAEVNT-----------QLRLHMEKADVVNKALREDVE-------KLTVDWSRAR 149
Query: 374 DEFFHEREDLEFKINELLLA---KEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLK 430
DE R++ ++++ + K E G ++ L E+ + F +R++ LK
Sbjct: 150 DELM--RKESQWQMEQEFFKGYLKGEHGRLLS-LWREVVTFRRHFLEMKSATDRDLMELK 206
Query: 431 EQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEIL 490
+H + L+ + L+ L L Q + ++ A L ++ +
Sbjct: 207 AEHVR----LSGSLLTCC----LRLTVGAQSREPNGSGRMDGREPAQL-------LLLLA 251
Query: 491 QT-ELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLS 549
+T EL + A + SQE +K Q + ELQ ++ TE ALL + + EK++
Sbjct: 252 KTQELEKEAHERSQELIQLKSQGDLEKAELQDRV----TELSALLTQSQKQNEDYEKMIK 307
Query: 550 Q-QELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHE 608
+E V LE L E + + L+++ I + E+ D I + + HE
Sbjct: 308 ALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ-GSGHE 366
Query: 609 EMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEK 668
LEL + Y + ++ + + L + Q+L
Sbjct: 367 NS--------------LELDSSIFSQFDYQ-DADKALTLVRSVLTRRRQAVQDLRQQLAG 411
Query: 669 LMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLE 728
+ +L + + E K+L + KL+ E+ L+ + V L+ + L
Sbjct: 412 CQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAG---------QTVDLQGEVDSLS 462
Query: 729 KKLQLMVEEQDNLNK---LLENE--QVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVL 783
K+ +L+ + ++ L + +LE E +++++ V+ QL G EE+
Sbjct: 463 KERELLQKAREELRQQLEVLEQEAWRLRRVNVELQL------QGDSAQGQKEEQ------ 510
Query: 784 QAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLL 843
+E+ +LA + E++ E+ ++ Q ES+ + L+ L E LL
Sbjct: 511 -----------QEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELL 559
Query: 844 RKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFI 903
R+E E+ + + + E+ + S+ K+E+
Sbjct: 560 RQEQTEVTAALARAEQSIAELSS-------------------SENTLKTEV--------- 591
Query: 904 KEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEK 963
+LR +L L ++LA N L +LEE+ +++ +
Sbjct: 592 ------------ADLRAAAVKLSALNEALALDKVGLNQQLL---QLEEENQSVCSRMEAA 636
Query: 964 EEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLL 1023
E+ N +++ +A+K ++ ++ ++ +L+ +L A +RD+ + E + L
Sbjct: 637 EQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKL 696
Query: 1024 LEYEKQSEQLDVEKERANNFEHRIED-----------LTRQLRNSTLQCETINSDNEDLL 1072
E Q E + E+ + R E+ L R+ ++ + + D +DL
Sbjct: 697 SESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLA 756
Query: 1073 ARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQ 1132
+++ L S +LLE + E Q+ ++++ ++Q + + E+ L+++L
Sbjct: 757 EQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELD 816
Query: 1133 KEKKQLQKTMQEL--ELVKKDAQQTTLMNMEIADYERLMKELNQK--------------- 1175
E+ Q ++ +L + + + T + + A +E+ + +L +K
Sbjct: 817 TERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKA 876
Query: 1176 LTNKNNKIEDLEQEIKIQKQKQETLQ----EEITSLQSSVQQY----EEKNTKIKQLLVK 1227
L + + +LE +K Q+ + E +Q EE T +S++ Q E++ + + L++
Sbjct: 877 LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQ 936
Query: 1228 TKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEIT----SEKHKIHEHLKT 1283
T+KELAD+ Q +LE +Q ++V K++ E T ++ + LK
Sbjct: 937 TQKELADASQ--------------QLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKE 982
Query: 1284 SAEQHQRTLSAYQQRVTA-------LQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKN 1336
+A QH+ L+A Q+ ++ LQ++ K++ + V L++ +
Sbjct: 983 AARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQE 1042
Query: 1337 KSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVS----ELQTLQSEHDTLLER 1392
+ Q E E K M +Q + LQ++ + Q +S ++Q Q E L +
Sbjct: 1043 YNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQ 1102
Query: 1393 HNKMLQETVSKEAE--------LREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFR 1444
+ QE KEA+ L E S +E + S Q +Q ++ S
Sbjct: 1103 MELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAK--AAQLQLRLRSTE 1160
Query: 1445 DQVRHLQEEHRKTVET-LQQQLSKMEAQLFQ-----LKNEPTTRSPVSSQQSLKNLRERR 1498
Q+ L E + + Q QL+ + + L Q ++ P S S+ L +
Sbjct: 1161 SQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQ 1220
Query: 1499 NTDLPLLDMHTVTREEGEGMETTDTESVSSA-------STYTQSLEQLLNSPETKLEPPL 1551
N L + G + E+V+SA TQ +L KLE L
Sbjct: 1221 NGARSLF-------KRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273
Query: 1552 WHAEFTK-------EELVQKLSSTTKSADHLNGLLRETEATNAILME-----QIKLLKSE 1599
E K ++L ++LS + G E+ L E Q +L ++E
Sbjct: 1274 TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE 1333
Query: 1600 IRRLERNQEREKSAANLEYL 1619
++R+E ERE A E L
Sbjct: 1334 LQRMEAQGERELLQAAKENL 1353
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 202 bits (513), Expect = 3e-51
Identities = 312/1520 (20%), Positives = 645/1520 (42%), Gaps = 164/1520 (10%)
Query: 11 SPATPGTGKSKLETLPKEDL-IKFAKKQM-----MLIQKAKSRCTELEKEIEELRSKPVT 64
S T G + KL+ L D+ +K+ +K++ +L + TEL+ + +EL + +
Sbjct: 155 SNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLA--LG 212
Query: 65 EGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDA-------- 116
G+ I L L+ E + E+Q LK N +++ VED +TK+ +A
Sbjct: 213 REKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME 272
Query: 117 ---HKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQ 173
H EL +HI ++ ++ A ++ + L K L+EA + + L
Sbjct: 273 EKFHNEL-NAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEV 331
Query: 174 NNSEDNV-KKLQEEIEKIRPGFE--EQILYLQKQLDATTDEKK-----ETVTQLQNIIEA 225
S+D + K++ E+I ++ E +L K+ A E++ T + I++
Sbjct: 332 EQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKP 391
Query: 226 N---SQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVK 282
++ Y + + Q++LL + + E K + ++ KE EA+ L +E +
Sbjct: 392 GMKLTELYNAYVET-QDQLL----LEKLENKRINKYLDEIVKEVEAKAPILKRQREE-YE 445
Query: 283 QCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLK 342
+ + + ++ K E ++ +++ + ++ N+ S+L ++N +E V + + + L
Sbjct: 446 RAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLM 505
Query: 343 ELESQ--HSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCV 400
ELE + +++DE ++ E+ +QH+ + E+L+ + LL+A E G
Sbjct: 506 ELEEARGNHVIRDEEVSSADISSSSEVISQHLVS--YRNIEELQQQNQRLLVALRELGET 563
Query: 401 IEKLKSELAGLN-KQFCYTVEQHNREVQSLKE--QHQKEI-------------------- 437
E+ + E + +E E++ L++ QHQ ++
Sbjct: 564 REREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTG 623
Query: 438 -------SELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEIL 490
S L++ L+ + K T Q + E EAI +L+++ EI
Sbjct: 624 VAIPLHASSLDDVSLASTPKRPST----SQTVSTPAPVPVIESTEAIEAKAALKQLQEIF 679
Query: 491 QTELGESA--GKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETV-NRLQGENEKL 547
+ E A KI E Q+Q +D+ K+ T E + + ++G ++
Sbjct: 680 ENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREI 739
Query: 548 LSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSH 607
S E +L T + ++ L + L E + +L +EK+ + KL
Sbjct: 740 TSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKE--MLKLSEVR 797
Query: 608 EEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLE 667
E+ + +L + Q I SE E K L+ +E+ E +KLE
Sbjct: 798 LSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKKLE 856
Query: 668 KLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQL 727
+ Q L+ + +V + K + L K+L ++ +QKE LK+H++ +
Sbjct: 857 NEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN-----AQKEIATLKQHLSNM 911
Query: 728 EKKLQLMVEEQDNLNKLLENEQVQKLFVK--------TQLYGFLKEMGSEVS-------- 771
E ++ ++ + E V L + L LK S V
Sbjct: 912 EVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTS 971
Query: 772 -EDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELK 830
E+S K+ V + V +++ +E Q ++K++E+EKE + LQ++ +
Sbjct: 972 LEESLNKE-KQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDK-------R 1023
Query: 831 SLLRDYEQEKVLLRKELEEIQSE-KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTC 889
+ EQ+ L+K L +Q+E +EALQ + N + R + I VE ++
Sbjct: 1024 RAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYE 1083
Query: 890 SKSEIHNEKEKCFIKEHENLKPLLE-----QKELRDRRAELILLKDSLAKSPSVKNDPLS 944
+ +H + E + + ++ + ++L+ K S + + D
Sbjct: 1084 RELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKD--- 1140
Query: 945 SVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKE---------LDSSRKETQTVKEEL 995
V + + E+LEK+ + ++I K+ V + KE L K + + E L
Sbjct: 1141 EVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEIL 1200
Query: 996 ESLRSEKD----QLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI---E 1048
+R EK+ + + + ++ + + L E ++ + L+ E+E+ + E
Sbjct: 1201 RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHE 1260
Query: 1049 DLTRQLRNSTLQCET---INSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKE--- 1102
+L ++ + ET + + E L ++ +Q+ + LE+ IL +Q A A + ++
Sbjct: 1261 ELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGM 1320
Query: 1103 LEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEI 1162
L+AEK E+ +K L + Q + ++ +K + E E+ K QQ T EI
Sbjct: 1321 LQAEKKLLEEDVKRWKARNQHL--VSQQKDPDTEEYRKLLSEKEVHTKRIQQLT---EEI 1375
Query: 1163 ADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIK 1222
+ + N LTN N I+ L++++ + ++ET+Q+++ + +Q+ + T++K
Sbjct: 1376 GRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVK 1435
Query: 1223 QLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQ-LAEITSEKHKIHEHL 1281
++ + K + + K A+ D +++ S + + +Q V V ++Q L E ++ + L
Sbjct: 1436 KIGRRYKTQYEELK-AQQDK-VMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSL 1493
Query: 1282 KTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQ-QKNKSMS 1340
++ E Q+TLS + LQE+ ++E + + + + + + +Q + + +
Sbjct: 1494 ESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKT 1553
Query: 1341 QAETEGAKQEREHLEMLIDQLKIK----------LQDSQNNLQINVSELQTLQSEHDTLL 1390
+ AK + HL + DQL + L ++ L + ++ L+S+++ +
Sbjct: 1554 RKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRIT---ALKSQYEGRI 1610
Query: 1391 ERHNKMLQETVSKEAELREK 1410
R + L+E + E R++
Sbjct: 1611 SRLERELREHQERHLEQRDE 1630
Score = 195 bits (495), Expect = 4e-49
Identities = 330/1648 (20%), Positives = 697/1648 (42%), Gaps = 263/1648 (15%)
Query: 19 KSKLETLPKE---DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALT 75
+++L LPK L KF Q I K R + + E E+ +I K L+
Sbjct: 11 RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYF--------EIEKRLS 62
Query: 76 ERLDALLLEKAETEQQCLSLKKENIKMKQEVEDS--VTKMGDAHKELEQSHINYVKEIEN 133
+ L+ E E + L L+K N ++K E + + D + ++ +E+E
Sbjct: 63 HSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEA 122
Query: 134 LKNELMAVRSKYS-------EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEE 186
K +L+ + S ED L ++L+E+ T+ EL +L S+ +VK ++
Sbjct: 123 EKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR 182
Query: 187 IEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNII---EANSQHYQKNINSLQEELLQ 243
+E+ + Q +L +L TDE + N I + N ++ ++ ++ L+E++
Sbjct: 183 LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNG 242
Query: 244 LKAIH---QEEVKELMCQIEASAKEHEA--------EIN---KLNELKENLVKQCEASEK 289
LK + Q+ V++L+ +++ AKE +A E+N KL+ L ++ EA
Sbjct: 243 LKTSNEHLQKHVEDLLTKLK-EAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSN 301
Query: 290 NIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHS 349
+ + E EL L K AN+ Q LL+ +Q+ E ++ + KELE+ +
Sbjct: 302 ELTRAVE-ELHKLLKEAGEANKAIQ--DHLLEVEQSKDQMEKEMLEKIGRLEKELENAND 358
Query: 350 IL-----------KDEVTYMN------------NLKLKLEMDAQHIKDEFFHEREDLEFK 386
+L ++E+ M+ +KL E+ +++ + E LE K
Sbjct: 359 LLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLT-ELYNAYVETQDQLLLEKLENK 417
Query: 387 -----INELLLAKEEQGCVIEKLKSELAGLNK---QFCYTVEQHNREVQSLKEQHQKEIS 438
++E++ E + ++++ + E K +EQ +E+Q L+E K
Sbjct: 418 RINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANK 477
Query: 439 ELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEA---------------------- 476
+ S E++ + +++ L +Q L E +EA
Sbjct: 478 QS-----SVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEV 532
Query: 477 ----ILNYESLREIME------ILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTA 526
+++Y ++ E+ + + ELGE+ + QE S K + ELQ KL +A
Sbjct: 533 ISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSK------ITELQLKLESA 586
Query: 527 FTEKDALLETVNRLQGENEKLLSQQEL--------------------------------- 553
TE + L ++ + ++ Q+++
Sbjct: 587 LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
Query: 554 ----------VPELENT--------IKNLQEKNGVYLLSLSQRDTM----LKELEGKINS 591
VP +E+T +K LQE Y ++ + + L++L+ ++
Sbjct: 647 TSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTD 706
Query: 592 LTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGG 651
L + +L + + + E R I L ++ ++ + EQ +N +T
Sbjct: 707 LRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQD 766
Query: 652 LEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVF 711
L ++KL V+ + L ++KE+L L ++ L +E++ ++L +
Sbjct: 767 LRGA-------NEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQR--GQNLLLT 817
Query: 712 LSQKEDVILKEHITQLEKKLQLMVE----EQDNLNKLLENEQVQKLFVK----TQLYGFL 763
Q IL+ T+ +++L +E E +L K LENE Q+ + QL
Sbjct: 818 NLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK 877
Query: 764 KEMGSEVSEDSEEKDVV-NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEES 822
+++ +E + K+++ N + + ++ + +A Q ++ + + K ++
Sbjct: 878 RQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDL 937
Query: 823 VVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQV 882
V Q + + + D ++ +E+ Q+ +L+ L + K E+ R + L +
Sbjct: 938 VSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
Query: 883 EEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDP 942
E K + EKEK +++ + ++ + +L LK +L+ SV+N+
Sbjct: 998 AEFQTQLEKKLMEVEKEKQELQDDK-------RRAIESMEQQLSELKKTLS---SVQNEV 1047
Query: 943 LSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEK 1002
+++ + N ++ ++ +E+ +AV+A+ + + +E ++E+L++ K
Sbjct: 1048 QEALQRASTALSNEQQARRDCQEQAK----IAVEAQNKYE---RELMLHAADVEALQAAK 1100
Query: 1003 DQLS--ASMRD-LIQGAESYKNLLLEYEKQSEQLD-VEKERANNFEHRIEDLTRQLRNST 1058
+Q+S AS+R L + + ++ LLE + E+ + + K+ + R EDL +Q R
Sbjct: 1101 EQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLH 1160
Query: 1059 LQCETIN-----SDNEDLLARIETLQSNAKLLEVQILEV----QRAKAMVDKELEAEKLQ 1109
Q E ++ S E + + S + QILE+ +R K + + E +++
Sbjct: 1161 DQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVE 1220
Query: 1110 KEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLM 1169
+ + EL+ELQ L E++++Q T + + ++ ++T MN+ + + L
Sbjct: 1221 SLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLR 1280
Query: 1170 KE---LNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLV 1226
+E L Q L K+ LE +I ++ L E+ LQ+ + EE +K+
Sbjct: 1281 EEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEED---VKRWKA 1337
Query: 1227 KTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAE 1286
+ + ++ K +T+ E + EV+ ++ ++T E + LK
Sbjct: 1338 RNQHLVSQQKDPDTE----------EYRKLLSEKEVHTKRIQQLTEEIGR----LKAEIA 1383
Query: 1287 QHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEG 1346
+ +L+ Q + +L+E+ + E+ T+ + ++ + + Q+K K+++Q + G
Sbjct: 1384 RSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDI-----QEKVKTITQVKKIG 1438
Query: 1347 AKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAE 1406
+ + ++ E+ Q K+ +Q++ Q +H ++ E L+ET++ +AE
Sbjct: 1439 RRYKTQYEELKAQQDKVMETSAQSS--------GDHQEQHVSVQEMQE--LKETLN-QAE 1487
Query: 1407 LREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLS 1466
+ K Q EN+ +T ++ + V S ++R ++ E L+QQ++
Sbjct: 1488 TKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQIT 1547
Query: 1467 KMEAQLFQLKNEPTTRSPVSSQQSLKNL 1494
+ K E T ++ V+++ + +L
Sbjct: 1548 E--------KEEKTRKAIVAAKSKIAHL 1567
Score = 181 bits (460), Expect = 4e-45
Identities = 329/1625 (20%), Positives = 661/1625 (40%), Gaps = 264/1625 (16%)
Query: 150 ANLQKQLEEAMNTQLELSEQLKFQN---NSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
A LQ+ LE +L S Q K + + + + L+ EK + E+Q ++K+L
Sbjct: 3 AVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS 62
Query: 207 ATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEH 266
+ + + Q++ + + +L E+ +L+ I Q+ + Q + +E
Sbjct: 63 HSQERLVNETRECQSL-RLELEKLNNQLKALTEKNKELE-IAQDRNIAIQSQFTRTKEEL 120
Query: 267 EAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFV 326
EAE L E L ++ E +++++
Sbjct: 121 EAEKRDLIRTNERLSQELEYLTEDVKR--------------------------------- 147
Query: 327 EQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFK 386
+NEK+K T EL+ + L+ + + +LE + + + + +L+ K
Sbjct: 148 ---LNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTK 204
Query: 387 INELLLAKEEQG-------CVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISE 439
+ELL E+G C +E K E++ L +Q ++ N +Q E ++ E
Sbjct: 205 TDELLALGREKGNEILELKCNLENKKEEVSRLEEQM-NGLKTSNEHLQKHVEDLLTKLKE 263
Query: 440 LNETFLSDSEK--EKLTLMFEIQGL-KEQCENLQQEKQEAILNYESLREIMEILQTELGE 496
E S EK +L ++ L K ++ + + E E L ++++ E GE
Sbjct: 264 AKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLK----EAGE 319
Query: 497 SAGKISQ---EFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQG--ENEKLLSQQ 551
+ I E E K Q ++ E +L + LL R E+L +
Sbjct: 320 ANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMS 379
Query: 552 ELVPELENTIKNLQEKNGVYLLSLSQRDTMLKE-LEGKINSLTEEKDDFINKLKNSHEEM 610
+ +K + +Y + +D +L E LE K + + D+ + +++ +
Sbjct: 380 PTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENK--RINKYLDEIVKEVEAKAPIL 437
Query: 611 DNFHKKCEREERLILELGKKVEQTIQYNSELEQ---KVNELTGGLEE-----TLKEKDQN 662
++ ER ++ + L K+EQ ++ L++ K N+ + LE ++ KD +
Sbjct: 438 KRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLS 497
Query: 663 DQKLEKLMVQMKV-----LSEDKEVLSAEVKS----------LYEENNKLSSEKKQL--- 704
Q++ L+++++ + D+EV SA++ S Y +L + ++L
Sbjct: 498 -QQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVA 556
Query: 705 SRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQ--VQKLFVKTQLYGF 762
R+L ++E IT+L+ KL+ + E + L K +++ V + + +Y
Sbjct: 557 LRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRI 616
Query: 763 LKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEES 822
L + V+ + +V A S K ++ V+E + I E+
Sbjct: 617 LLSQTTGVAIPLHASSLDDVSLA---STPKRPSTSQTVSTPAPVPVIESTEAI-----EA 668
Query: 823 VVQCEELKSLLRDYEQEKVLLRKELEEIQSEK-EALQSDLLEMKNANEK--TRLE----- 874
++L+ + +Y++EK E E+IQ+E+ E LQ + ++++ N K T+L+
Sbjct: 669 KAALKQLQEIFENYKKEKA----ENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKR 724
Query: 875 ---------------------NQNLLIQVEEVSQTCS--KSEIHNEKEKCFIKE--HENL 909
NQ L ++ Q + ++ EK + E ENL
Sbjct: 725 YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
Query: 910 KPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEK-EEKIN 968
K E++ L+ L ++SL +N L++++ ++ +E E E K++ +I
Sbjct: 785 KK--EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIE 842
Query: 969 KIKLVAVKAKKELDSSRKETQTVKEELE-SLRSEKDQLSA------SMRDLIQGAES--- 1018
K++ KK+L++ ++ T+ L+ L K QL + ++L++ A+
Sbjct: 843 KLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIA 902
Query: 1019 -----YKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLA 1073
N+ ++ QS Q + + +N + ++DL QLR + E +N DL
Sbjct: 903 TLKQHLSNMEVQVASQSSQRTGKGQPSN--KEDVDDLVSQLRQTE---EQVN----DLKE 953
Query: 1074 RIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQK 1133
R++T SN + + + ++ + + E + E ++KE A +LE+ ++++K
Sbjct: 954 RLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEK 1013
Query: 1134 EKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQK----LTNKNNKIEDLEQE 1189
EK++LQ + ++ QQ + + ++ + ++E Q+ L+N+ D +++
Sbjct: 1014 EKQELQD--DKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQ 1071
Query: 1190 IKIQKQKQ--------------ETLQ---EEITSLQSSVQQYEEKNTKIKQLLVKTK--- 1229
KI + Q E LQ E+++ + S Q EE K + L++ K
Sbjct: 1072 AKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASW 1131
Query: 1230 -------------------------KELADSKQAETDHLI--LQASLKGELEASQQQVEV 1262
+ L D + +D ++ ++ ++G L S +
Sbjct: 1132 EERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGK 1191
Query: 1263 YKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFES 1322
+ Q+ EI + E +T E Q Y+QRV L+ E + Q ++ +E E
Sbjct: 1192 SQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQEL---QDSLNAERE- 1247
Query: 1323 YKVRVHNVLKQQKNKSMSQAETEGA--------KQEREHLEMLIDQLKIKLQDSQNNLQI 1374
KV+V Q + M + ET ++E+E LE + Q++ K++ + ++ +
Sbjct: 1248 -KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDI-L 1305
Query: 1375 NVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSEN--------MMMKSEHT 1426
+ E SE +L+ K+L+E V + + L S Q + + K HT
Sbjct: 1306 PLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHT 1365
Query: 1427 QTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTR---- 1482
+ + QLT + L+ L ++ +++L++ L+K+ + ++ + +
Sbjct: 1366 KRIQQLTEEIGRLKAEIARSNASL-TNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDI 1424
Query: 1483 -SPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541
V + +K + R T L E + D + + Q L++ LN
Sbjct: 1425 QEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLN 1484
Query: 1542 SPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIR 1601
ETK + + E V+ L T +ETEA N L EQ L+SE+
Sbjct: 1485 QAETKSK--------SLESQVENLQKTLSE--------KETEARN--LQEQTVQLQSELS 1526
Query: 1602 RLERN 1606
RL ++
Sbjct: 1527 RLRQD 1531
Score = 179 bits (455), Expect = 2e-44
Identities = 286/1314 (21%), Positives = 551/1314 (41%), Gaps = 155/1314 (11%)
Query: 408 LAGLNKQFCYTVEQHNREVQS-LKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQC 466
L G +++F EQ E++ L ++ ++E E E EKL + K +
Sbjct: 39 LKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKE 98
Query: 467 ENLQQEKQEAILN-YESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRT 525
+ Q++ AI + + +E +E + +L + ++SQE E + + DV L +KL+
Sbjct: 99 LEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTE----DVKRLNEKLKE 154
Query: 526 AFTEKDALLETVNRLQGEN------EKLLSQQELVPELENTIKNLQEKNGV-YLLSLS-Q 577
+ T K L ++ LQ + EK L Q++ + +NT N + K LL+L +
Sbjct: 155 SNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGRE 214
Query: 578 RDTMLKELEGKINSLTEEK---DDFINKLKNSHEEMDNF------------HKKCEREER 622
+ + EL+ + + EE ++ +N LK S+E + ++ EE+
Sbjct: 215 KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEK 274
Query: 623 LILELGKKVEQTIQYNS---ELEQKVNELTGGLEET---LKEKDQNDQKLEKLMVQMKVL 676
EL ++ + Y S + E K NELT +EE LKE + ++ ++ +++++
Sbjct: 275 FHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQS 334
Query: 677 SEDKEVLSAEV-----KSLYEENNKLSSEKKQ---LSRDLEVFLSQKEDVILK-----EH 723
+ E E K L N+ LS+ K++ LS + +S + K
Sbjct: 335 KDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMK 394
Query: 724 ITQL-----EKKLQLMVEEQDN------LNKLLENEQVQKLFVKTQLYGFLKEMGSEVSE 772
+T+L E + QL++E+ +N L+++++ + + +K Q + + + S
Sbjct: 395 LTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASL 454
Query: 773 DSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKS- 831
+ + + +Q + E K N++ L +RD + +E++ +K L ++ V EL+
Sbjct: 455 SVKLEQAMKEIQRLQEDTDKANKQSSVL--ERDNRRMEIQ--VKDLSQQIRVLLMELEEA 510
Query: 832 ----LLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQ 887
++RD E +I S E + L+ +N E+ + +NQ LL+ + E+ +
Sbjct: 511 RGNHVIRDEEVSSA-------DISSSSEVISQHLVSYRNI-EELQQQNQRLLVALRELGE 562
Query: 888 TCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVK 947
T + E K + + L E ++LR R + L DS+ + + LS
Sbjct: 563 TREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTT 622
Query: 948 ELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSA 1007
+ + ++ + L + K+ S T +ES +E + A
Sbjct: 623 GVAIPLH---------ASSLDDVSLASTP-KRPSTSQTVSTPAPVPVIES--TEAIEAKA 670
Query: 1008 SMRDLIQGAESYKNLLLEYEK-QSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINS 1066
+++ L + E+YK E EK Q+EQL+ +E+ + + ++ QL ++ + E +
Sbjct: 671 ALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQD 730
Query: 1067 DNEDLLARIETL-QSNAKLLEVQILEVQRAKAMVDK-----------ELEAEKLQKEQKI 1114
+ E I +L + N KL + Q M E+ AE L+KE+++
Sbjct: 731 NVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEM 790
Query: 1115 KEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQ 1174
+ L E+++ Q+E ++ Q L L Q L E +RL ++ +
Sbjct: 791 LK-------LSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEK 843
Query: 1175 KLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELAD 1234
++ + LE E++ + L ++ + + + K+LL +KE+A
Sbjct: 844 LEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT 903
Query: 1235 SKQAETDHLILQASLKGELE-----ASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQ 1289
KQ ++ + AS + ++++ V+ QL + + + + E LKTS +
Sbjct: 904 LKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVE 963
Query: 1290 RTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQ 1349
+ YQ VT+L+E K V E VR+ + Q E E KQ
Sbjct: 964 Q----YQAMVTSLEESLNKEKQVTEEVRKNIE---VRLKESAEFQTQLEKKLMEVEKEKQ 1016
Query: 1350 ER--------EHLEMLIDQLKIKLQDSQNNLQINVSELQTL-----------QSEHDTLL 1390
E E +E + +LK L QN +Q + T Q + +
Sbjct: 1017 ELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAV 1076
Query: 1391 ERHNKMLQETVSKEAELREKLCSIQSENMM--MKSEHTQTVSQLTSQNEVLRNSFRDQVR 1448
E NK +E + A++ + + + M ++ +T + SQ + S+ ++ R
Sbjct: 1077 EAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERER 1136
Query: 1449 HLQEEHRKTV---ETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLK-NLRERRNTDLPL 1504
L++E K V E L++Q + Q+ +L ++ Q L +L E + +
Sbjct: 1137 MLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQI 1196
Query: 1505 LDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQK 1564
L++ R E E ET + + Y Q +E L E L + + +K
Sbjct: 1197 LEILRFIRREKEIAETRFEVAQVESLRYRQRVELL--------ERELQELQDSLNAEREK 1248
Query: 1565 LSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERN-QEREKSAANLE 1617
+ T K+ L+++TE N ++ME K+L+ E RLE++ Q+ + LE
Sbjct: 1249 VQVTAKTMAQHEELMKKTETMN-VVMETNKMLREEKERLEQDLQQMQAKVRKLE 1301
Score = 118 bits (295), Expect = 6e-26
Identities = 192/893 (21%), Positives = 359/893 (40%), Gaps = 123/893 (13%)
Query: 44 AKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMK 103
A+ R L+KE E L+ V +R LLL +T Q L ++ + K
Sbjct: 777 AEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGIL--ERSETETK 834
Query: 104 QEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQ 163
Q + + K+ E E SH+ K++EN + + + ++QL+ N
Sbjct: 835 QRLSSQIEKL-----EHEISHLK--KKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLH 887
Query: 164 LELSEQLKFQNNSEDNVKKLQEEIEKI---------------RPGFEEQILYLQKQLDAT 208
L E LK N++ + L++ + + +P +E + L QL T
Sbjct: 888 LNTKELLK---NAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQT 944
Query: 209 TDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQE----------EVKELMCQ 258
++ + +L+ +N + YQ + SL+E L + K + +E E E Q
Sbjct: 945 EEQVNDLKERLKTST-SNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQ 1003
Query: 259 IEASAKEHEAEINKLNELKENLVKQCEA-------SEKNIQKKYECELENLRKATSNANQ 311
+E E E E +L + K ++ E + ++Q + + L+ A SN Q
Sbjct: 1004 LEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQ 1063
Query: 312 DNQICS-----------------ILLQENTFVEQVVNEKV-------KHLEDTLKELESQ 347
+ C +L + Q E+V +HLE+T ++ ESQ
Sbjct: 1064 ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ 1123
Query: 348 -----------HSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINE-----LL 391
+LKDEV+ LE + + D+ + + + E L
Sbjct: 1124 LLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLN 1183
Query: 392 LAKEEQGCVIEKLKSELAGLNKQFCYTVEQHN-REVQSLKEQHQKEISELNETFLSDS-- 448
++ E+G E++ L + ++ + +V+SL+ + + E+ E L DS
Sbjct: 1184 VSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLN 1243
Query: 449 -EKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQ-EFE 506
E+EK+ + + E+ + + + LRE E L+ +L + K+ + E +
Sbjct: 1244 AEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELD 1303
Query: 507 SMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQE 566
+ Q+A+ EL +K EK L E V R + N+ L+SQQ+ P+ E K L E
Sbjct: 1304 ILPLQEANA--ELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQK-DPDTEEYRKLLSE 1360
Query: 567 KNGVYLLSLSQRDTMLKELEGKI---NSLTEEKDDFINKLKNS----HEEMDNFHKKCER 619
K V+ + Q + L+ +I N+ + I LK E + K +
Sbjct: 1361 KE-VHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDA 1419
Query: 620 EERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSED 679
+ I E K + Q + + + EL ++ ++ Q+ ++ V ++ + E
Sbjct: 1420 KIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQEL 1479
Query: 680 KEVLS-AEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQ 738
KE L+ AE KS E+ + +K ++ E Q++ V L+ +++L + LQ ++
Sbjct: 1480 KETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQE 1539
Query: 739 DNLNKLL--ENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEE 796
+ L + + + E+ +K V K + L V + L K NEE
Sbjct: 1540 EQLRQQITEKEEKTRKAIVAA-------------------KSKIAHLAGVKDQLTKENEE 1580
Query: 797 KCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEE 849
D++ EL+ I L+ + + L+ LR++++ + R E +E
Sbjct: 1581 LKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
Score = 80.9 bits (198), Expect = 1e-14
Identities = 98/439 (22%), Positives = 189/439 (43%), Gaps = 85/439 (19%)
Query: 23 ETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSK---------PVTEGTGDIIKA 73
E + K + + + ++++ K R LE++++++++K P+ E +
Sbjct: 1261 ELMKKTETMNVVMETNKMLREEKER---LEQDLQQMQAKVRKLELDILPLQEANAE---- 1313
Query: 74 LTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIEN 133
L+E+ L EK E+ K N + + +D T+ + K L + + + K I+
Sbjct: 1314 LSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE--EYRKLLSEKEV-HTKRIQQ 1370
Query: 134 LKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPG 193
L E+ ++++ + A+L N+++ ++ L+E++ K+R
Sbjct: 1371 LTEEIGRLKAEIARSNASL---------------------TNNQNLIQSLKEDLNKVRTE 1409
Query: 194 FEEQILYLQKQLDATT---DEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQE 250
E +QK LDA EK +T+TQ++ I Y+ +LKA Q+
Sbjct: 1410 KET----IQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYE-----------ELKA-QQD 1453
Query: 251 EVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNAN 310
+V E Q +E + ++ ELKE L Q E K++ E ++ENL+K S
Sbjct: 1454 KVMETSAQSSGDHQEQHVSVQEMQELKETL-NQAETKSKSL----ESQVENLQKTLSEKE 1508
Query: 311 QDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQ 370
+ + LQE T Q ++ L L++ +Q L+ ++T K + A+
Sbjct: 1509 TEARN----LQEQTVQLQ---SELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAK 1561
Query: 371 H-------IKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHN 423
+KD+ E E+L+ + L K+E I LKS+ G + +
Sbjct: 1562 SKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEG-------RISRLE 1614
Query: 424 REVQSLKEQHQKEISELNE 442
RE++ +E+H ++ E E
Sbjct: 1615 RELREHQERHLEQRDEPQE 1633
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 200 bits (509), Expect = 8e-51
Identities = 297/1379 (21%), Positives = 595/1379 (43%), Gaps = 220/1379 (15%)
Query: 178 DNVKKLQEEIEKIRPGFEEQILY---LQKQLDA--------------TTDEKKETVTQLQ 220
D+V L++E++ ++ +E+ Y L+K+L+ TD E + Q
Sbjct: 83 DDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQ 142
Query: 221 NIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENL 280
+ EA ++++ NI +++ Q A E+ ++ + + EA K+ L E L
Sbjct: 143 QLEEAQTENF--NIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEEL 200
Query: 281 VKQC----EASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKH 336
K+ + + +Q+ ++ L+K L+Q T ++ + E+ +
Sbjct: 201 NKEATVIQDLKTELLQRPGIEDVAVLKKE-------------LVQVQTLMDNMTLERERE 247
Query: 337 ---LEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLA 393
L+D K+L+SQ++ E T ++ L+ +L Q + + E + L+ +NEL
Sbjct: 248 SEKLKDECKKLQSQYA--SSEAT-ISQLRSELAKGPQEVA-VYVQELQKLKSSVNEL--T 301
Query: 394 KEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKE----QHQKEIS-ELNETFLSDS 448
++ Q LK E + + E+HN E S K HQK++ + ++ LS S
Sbjct: 302 QKNQTLTENLLKKE-----QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSAS 356
Query: 449 EKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESM 508
E + E+ E + L++E E Y+ L+ + LQ + +E E
Sbjct: 357 ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQ--------REEKEQH 408
Query: 509 KQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPEL----ENTIKNL 564
Q S++++L KL LET +L + +L Q++L E E + +L
Sbjct: 409 GLQLQSEINQLHSKL----------LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADL 458
Query: 565 QEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLI 624
Q L LS+ + LKE K+ + TE + ++K K H+E + + R
Sbjct: 459 Q-------LKLSRLEEQLKE---KVTNSTELQHQ-LDKTKQQHQEQQALQQSTTAKLR-- 505
Query: 625 LELGKKVEQTIQYNSELEQKVNELTGGLEET-----LKEKDQND-----QKLEKLMVQMK 674
E +EQ ++ + +QK+ L L+++ L EK++ D Q E +
Sbjct: 506 -EAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLN 564
Query: 675 VLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLM 734
L E L +V L E+ S KQ +L + ++ K H+ + ++ +
Sbjct: 565 QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQ-----KAHLRAAQDRVLSL 619
Query: 735 VEEQDNLNKLLEN--EQVQKLFV----KTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGE 788
+ LN L E+V +L + KT+L + +E ++ ++ D+ N L
Sbjct: 620 ETSVNELNSQLNESKEKVSQLDIQIKAKTELL-----LSAEAAKTAQRADLQNHLDTAQN 674
Query: 789 SLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE 848
+L +E + Q D+ +L+ + QE C +L+S L++Y+++ + L ++ E
Sbjct: 675 ALQDKQQELNKITTQLDQVTAKLQDK----QEH----CSQLESHLKEYKEKYLSLEQKTE 726
Query: 849 EIQSEKEALQSDLLEMKNANEKTR--LENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEH 906
E++ + + L++D LE+K + E+ L+ Q L E+ T ++ EKE I
Sbjct: 727 ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE---IVSS 783
Query: 907 ENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEK 966
L +L+ + L +K L K K + L++ E L +E K + E+
Sbjct: 784 TRL-------DLQKKSEALESIKQKLTKQEEEK-------QILKQDFETLSQETKIQHEE 829
Query: 967 INKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEY 1026
+N + ++ E Q VK E E+L +E LS L + ++S KN E+
Sbjct: 830 LNN----------RIQTTVTELQKVKMEKEALMTE---LSTVKDKLSKVSDSLKNSKSEF 876
Query: 1027 EKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLE 1086
EK++++ K + E ++L QL+ +Q E + ++L +E + + L+
Sbjct: 877 EKENQK---GKAAILDLEKTCKELKHQLQ---VQMENTLKEQKELKKSLEKEKEASHQLK 930
Query: 1087 VQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQ-----KT 1141
+++ +Q L+ Q E++ ++ +NEL++ Q +K+ + LQ
Sbjct: 931 LELNSMQEQLIQAQNTLK----QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAV 986
Query: 1142 MQELELVKKDAQQTTLMNMEIA-----------DYER---LMKELNQKLTNKNNKIEDLE 1187
+Q+ EL K QQ T E+A +YE+ K+L + +++
Sbjct: 987 LQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATR 1046
Query: 1188 QEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQA 1247
Q++K ++K QE++ S ++ + + ++K +++ A +Q +
Sbjct: 1047 QDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQ 1106
Query: 1248 SLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECR 1307
++ E ++++ K +LAEI E +K E + +T L EE +
Sbjct: 1107 DIQKEKSLKEKELVNEKSKLAEI--------EEIKCRQE----------KEITKLNEELK 1148
Query: 1308 AAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAET--EGAKQEREHLEMLIDQLKIKL 1365
+ K E + + K +L QQK + +A++ +QE+ + ++L DQ+K +
Sbjct: 1149 SHKLESIKEITNLKDAK----QLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE 1204
Query: 1366 QDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEH 1425
++ + ++L + E + +++H + + + L E L +++ E
Sbjct: 1205 EELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKE----WQSS 1260
Query: 1426 TQTVSQLTSQNEVLRNS---FRDQVRHLQEEHRKTVETL---QQQLSKMEAQLFQLKNE 1478
+ VS+L Q + LR V++ Q+E R +E + ++ K++ ++ +L+ +
Sbjct: 1261 QRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRK 1319
Score = 190 bits (483), Expect = 9e-48
Identities = 290/1272 (22%), Positives = 587/1272 (46%), Gaps = 163/1272 (12%)
Query: 33 FAKKQM--MLIQKAKSRCTEL---------EKEIEELRSKPVTEGTGDIIKALT--ERLD 79
F KQM + QKA TE+ E+ + E + VT T ++ K T + L
Sbjct: 152 FNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLK 211
Query: 80 ALLLEKAETEQQCLSLKKENIKMKQEVEDSVT--------KMGDAHKELEQSHINYVKEI 131
LL++ E + LKKE +++ Q + D++T K+ D K+L+ + + I
Sbjct: 212 TELLQRPGIEDVAV-LKKELVQV-QTLMDNMTLERERESEKLKDECKKLQSQYASSEATI 269
Query: 132 ENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIR 191
L++EL +K ++ A ++L++ ++ EL++ K Q +E+ +KK Q+ +
Sbjct: 270 SQLRSEL----AKGPQEVAVYVQELQKLKSSVNELTQ--KNQTLTENLLKKEQDYTKLEE 323
Query: 192 PGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEE 251
EE + +K + AT +K QLQ+ + A+ + +++ + EL + K ++
Sbjct: 324 KHNEESVS--KKNIQATLHQKDLDCQQLQSRLSAS----ETSLHRIHVELSE-KGEATQK 376
Query: 252 VKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQ 311
+KE + ++E + +AE +L + +E E + +Q + E
Sbjct: 377 LKEELSEVETKYQHLKAEFKQLQQQRE------EKEQHGLQLQSEI-------------- 416
Query: 312 DNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQH 371
NQ+ S LL+ E+ + E L++ ++L S+ L D+ + +L+LKL +
Sbjct: 417 -NQLHSKLLE----TERQLGEAHGRLKEQ-RQLSSEK--LMDKEQQVADLQLKLSRLEEQ 468
Query: 372 IKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLN---KQFCYTVEQHNREVQS 428
+K++ + E L+ ++++ +EQ + + ++L +Q + ++++Q+
Sbjct: 469 LKEKVTNSTE-LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN 527
Query: 429 LKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIME 488
L+ QK S+ N + L EKE+ L +IQ E + A+LN L+E
Sbjct: 528 LEALLQK--SKENISLL---EKEREDLYAKIQA---------GEGETAVLN--QLQEKNH 571
Query: 489 ILQTELGESAGKISQEFESMKQQQAS---DVHELQQKLRTAFTEKDALLETVNRLQGENE 545
LQ ++ + K+ + ES KQ Q + V E + LR A +L +VN L N
Sbjct: 572 TLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL---NS 628
Query: 546 KLLSQQELVPELENTIKNLQEKNGVYLLSL-----SQRDTMLKELEGKINSLTEEKDDFI 600
+L +E V +L+ IK E LLS +QR + L+ N+L ++K +
Sbjct: 629 QLNESKEKVSQLDIQIKAKTE----LLLSAEAAKTAQRADLQNHLDTAQNAL-QDKQQEL 683
Query: 601 NKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLE----ETL 656
NK+ ++D K + ++ +L +++ + LEQK EL G ++ ++L
Sbjct: 684 NKITT---QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL 740
Query: 657 KEKDQNDQKLEKLMVQMKVLSEDKEVLSAEV-KSLYEENNKLSSEKKQLSRDLEVFLSQK 715
+ K +Q L+ L Q + L+ D E+ + E+ K L E +SS + L + E S
Sbjct: 741 EVKASKEQALQDLQ-QQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALES-- 797
Query: 716 EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSE 775
+K+ +T+ E++ Q++ ++ + L+ + ++Q +L ++ +E+ +
Sbjct: 798 ----IKQKLTKQEEEKQILKQDFETLS---QETKIQH----EELNNRIQTTVTELQKVKM 846
Query: 776 EKD-VVNVLQAVGESLAKINEEKCNLA--FQRDEK-----VLELEKEIKCLQEESVVQCE 827
EK+ ++ L V + L+K+++ N F+++ + +L+LEK K L+ + VQ E
Sbjct: 847 EKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQME 906
Query: 828 ELKSLLRDYEQEKVLLRKELE---EIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEE 884
+ L++ ++ K L KE E +++ E ++Q L++ +N ++ E Q L + E
Sbjct: 907 ---NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963
Query: 885 VSQTCSKSEIHNE----KEKCFIKEHENLKPLLEQK------ELRDRRAELILLKDSLAK 934
+ Q+ + + E + K + + L+ L+Q+ EL + ++ +L+++ K
Sbjct: 964 LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEK 1023
Query: 935 SPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRK---ETQTV 991
S S E ++ ++ K EEK++ + + + ++ + K E +T
Sbjct: 1024 SQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTA 1083
Query: 992 KEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLT 1051
K LE ++K+Q +Q + K+L + ++L EK + E E
Sbjct: 1084 KATLEQDSAKKEQQLQERCKALQDIQKEKSL------KEKELVNEKSKLAEIE---EIKC 1134
Query: 1052 RQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQ----RAKAMVDKELEAEK 1107
RQ + T E + S + + I L+ +LL Q LE+Q KA V++E ++
Sbjct: 1135 RQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQ 1194
Query: 1108 LQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVK-KDAQQTTLMNMEIADYE 1166
+ K+Q KE E E + +L E K+ + M++ E + K Q T +N + +
Sbjct: 1195 ILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVK 1254
Query: 1167 RLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLV 1226
+ + ++++ + +DL EI + + + Q+E +L + E + K++ ++
Sbjct: 1255 KEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVL 1314
Query: 1227 KTKKELADSKQA 1238
+ +++L ++ A
Sbjct: 1315 ELQRKLDNTTAA 1326
Score = 177 bits (450), Expect = 6e-44
Identities = 274/1329 (20%), Positives = 562/1329 (42%), Gaps = 248/1329 (18%)
Query: 317 SILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEF 376
++L QE ++ + E+ + E+ KELE + + E + L + Q ++ +
Sbjct: 86 TLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAK-PDGLVTDSSAELQSLEQQL 144
Query: 377 FHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKE 436
E + F I ++ E++ +L +E+A + ++ E +SL+E +++
Sbjct: 145 -EEAQTENFNIKQMKDLFEQKAA---QLATEIADIKSKY--------DEERSLREAAEQK 192
Query: 437 ISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYE--SLREIMEILQTEL 494
++ L E + KE IQ LK + + A+L E ++ +M+ + E
Sbjct: 193 VTRLTE----ELNKEATV----IQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLER 244
Query: 495 GESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELV 554
+ K+ E + ++ Q AS + Q LR+ + G E + QEL
Sbjct: 245 ERESEKLKDECKKLQSQYASSEATISQ-LRSELAK------------GPQEVAVYVQEL- 290
Query: 555 PELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFH 614
+L++++ L +KN +L +++ +LE K N + K + L +
Sbjct: 291 QKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ 350
Query: 615 KKCEREE----RLILELGKKVEQTIQYN---SELEQKVNELTGG---LEETLKEKDQNDQ 664
+ E R+ +EL +K E T + SE+E K L L++ +EK+Q+
Sbjct: 351 SRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGL 410
Query: 665 KLEKLMVQM--KVLSEDKEVLSAEVKSLYEENNKLSSEK----KQLSRDLEVFLSQKEDV 718
+L+ + Q+ K+L ++++ E +E +LSSEK +Q DL++ LS+ E+
Sbjct: 411 QLQSEINQLHSKLLETERQL--GEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE- 467
Query: 719 ILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKD 778
QL++K+ E Q L+K + Q Q+ + + + D
Sbjct: 468 -------QLKEKVTNSTELQHQLDKTKQQHQEQQAL----------QQSTTAKLREAQND 510
Query: 779 VVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQ 838
+ VL+ +G+ +D+K+ LE +LL+ ++
Sbjct: 511 LEQVLRQIGD---------------KDQKIQNLE------------------ALLQKSKE 537
Query: 839 EKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEK 898
LL KE E++ ++ +A + + + EK N +Q E+V+Q K + +E
Sbjct: 538 NISLLEKEREDLYAKIQAGEGETAVLNQLQEK------NHTLQ-EQVTQLTEKLKNQSES 590
Query: 899 EKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEK 958
K + ENL ++++++A L +D + + N+ S + E +EK+ L+
Sbjct: 591 HK---QAQENL-----HDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDI 642
Query: 959 ECKEKEEKINKIKLVAVKAKKEL----DSSRKETQTVKEELESLRSEKDQLSASMRDLIQ 1014
+ K K E + + + +L D+++ Q ++EL + ++ DQ++A ++D +
Sbjct: 643 QIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE 702
Query: 1015 GAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLAR 1074
++ L EY KE+ + E + E+L Q++ + + E L
Sbjct: 703 HCSQLESHLKEY----------KEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD 752
Query: 1075 IETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKE 1134
++ Q+ + D EL A +L K+ ++++ + L+ LQK+
Sbjct: 753 LQ----------------QQRQLNTDLELRATELSKQLEMEKEIVSSTRLD-----LQKK 791
Query: 1135 KKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQK 1194
+ L+ Q+L K++ ++ L D+E L +E + NN+I+ E++ K
Sbjct: 792 SEALESIKQKL--TKQEEEKQILKQ----DFETLSQETKIQHEELNNRIQTTVTELQKVK 845
Query: 1195 QKQETLQEEIT-----------SLQSSVQQYEEKNTKIKQLLV---KTKKELADSKQAET 1240
++E L E++ SL++S ++E++N K K ++ KT KEL Q +
Sbjct: 846 MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM 905
Query: 1241 DHLIL-QASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRV 1299
++ + Q LK LE ++ K++L + + + LK + ++ Q+ Q +
Sbjct: 906 ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL----QGNI 961
Query: 1300 TALQEECRAAKAEQATVTSEFES---YKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEM 1356
L++ K + + E + K + N L+QQ ++QA E A E+E + +
Sbjct: 962 NELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ----LTQAAQELAA-EKEKISV 1016
Query: 1357 LIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAEL---REKLCS 1413
L QNN + + + LQS+ +E+EL R+ L S
Sbjct: 1017 L-----------QNNYEKSQETFKQLQSDF--------------YGRESELLATRQDLKS 1051
Query: 1414 IQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLF 1473
++ + + + + +Q+ +QN+++ +E + TL+Q +K E QL
Sbjct: 1052 VEEKLSLAQEDLISNRNQIGNQNKLI------------QELKTAKATLEQDSAKKEQQL- 1098
Query: 1474 QLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYT 1533
+ + ++SLK +E N L ++ + + + + + E S
Sbjct: 1099 --QERCKALQDIQKEKSLKE-KELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHK---L 1152
Query: 1534 QSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQI 1593
+S++++ N + K + L+Q+ AD L + + + IL +Q+
Sbjct: 1153 ESIKEITNLKDAK------------QLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV 1200
Query: 1594 KLLKSEIRR 1602
K + E+++
Sbjct: 1201 KKEEEELKK 1209
Score = 152 bits (385), Expect = 2e-36
Identities = 253/1209 (20%), Positives = 500/1209 (41%), Gaps = 151/1209 (12%)
Query: 542 GENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTML--KELEGKINSLTEEKDDF 599
G ++L E V + N + E N L+L + D L +E++ SL EEK +
Sbjct: 51 GSADELFKHYEAVHDAGNDSGHGGESN----LALKRDDVTLLRQEVQDLQASLKEEKW-Y 105
Query: 600 INKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEK 659
+LK E+ ++ + + L+ + +++ LEQ++ E + K
Sbjct: 106 SEELKKELEKYQGLQQQEAKPDGLVTDSSAELQS-------LEQQLEEAQTENFNIKQMK 158
Query: 660 DQNDQKLEKLMVQMKVLSED-------KEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFL 712
D +QK +L ++ + +E +V L EE NK ++ + L +L
Sbjct: 159 DLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRP 218
Query: 713 SQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENE--QVQKLFVKTQLYGFLKEMGSEV 770
++ +LK+ + Q++ + M E++ ++ L++E ++Q + ++ + ++ SE+
Sbjct: 219 GIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSE--ATISQLRSEL 276
Query: 771 SEDSEE-----------KDVVNVL----QAVGESLAKINEEKCNLAFQRDEKVLELEKEI 815
++ +E K VN L Q + E+L K ++ L + +E+ + +K I
Sbjct: 277 AKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS-KKNI 335
Query: 816 KCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLEN 875
+ + + C++L+S L E + EL E + L+ +L E++ + + E
Sbjct: 336 QATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEF 395
Query: 876 QNLLIQVEEVSQ--TCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLA 933
+ L Q EE Q +SEI+ K E + + KE R +E ++ K+
Sbjct: 396 KQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ-- 453
Query: 934 KSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKE 993
V +L+ K+ LE++ KEK +++ K K++ + Q+
Sbjct: 454 -----------QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTA 502
Query: 994 ELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKE--------------- 1038
+L +++ +Q+ + D Q ++ + LL + ++ L+ E+E
Sbjct: 503 KLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 562
Query: 1039 ------RANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEV 1092
+ + + ++ LT +L+N Q E+ E+L +++ +++ + + ++L +
Sbjct: 563 LNQLQEKNHTLQEQVTQLTEKLKN---QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSL 619
Query: 1093 QRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDA 1152
+ + ++ +L K + Q + L + ++ LQ + + +D
Sbjct: 620 ETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679
Query: 1153 QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQ 1212
QQ E+ + ++ KL +K LE +K K+K +L+++ L+ ++
Sbjct: 680 QQ------ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIK 733
Query: 1213 QYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQV------------ 1260
+ E + ++K + ++L +Q TD + L +LE ++ V
Sbjct: 734 KLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSE 793
Query: 1261 --EVYKIQLAEITSEKHKIHEHLKTSAE----QHQRTLSAYQQRVTALQEECRAAKAEQA 1314
E K +L + EK + + +T ++ QH+ + Q VT LQ+ K E+
Sbjct: 794 ALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK----VKMEKE 849
Query: 1315 TVTSEFESYKVRVHNVLKQQKN-KSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ 1373
+ +E + K ++ V KN KS + E + K LE +LK +LQ N
Sbjct: 850 ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909
Query: 1374 INVSEL-QTLQSE----HDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMK---SEH 1425
EL ++L+ E H LE N M ++ + + L++ + E ++ +E
Sbjct: 910 KEQKELKKSLEKEKEASHQLKLEL-NSMQEQLIQAQNTLKQN----EKEEQQLQGNINEL 964
Query: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTT--RS 1483
Q+ Q Q E L+ + V E K LQQQL++ +L K + + +
Sbjct: 965 KQSSEQKKKQIEALQGELKIAVLQKTELENK----LQQQLTQAAQELAAEKEKISVLQNN 1020
Query: 1484 PVSSQQSLKNLRE---RRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLL 1540
SQ++ K L+ R ++L + EE + D S + L Q L
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
Query: 1541 NSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEI 1600
+ + LE E +E + L K L+E E N E+ KL +EI
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKS-----LKEKELVN----EKSKL--AEI 1129
Query: 1601 RRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGK---LA 1657
++ QE+E + N E LK+ L+ I E L ++Q E +GK L
Sbjct: 1130 EEIKCRQEKEITKLN-EELKSHKLESI-----KEITNLKDAKQLLIQQKLELQGKADSLK 1183
Query: 1658 AVAQGEEEN 1666
A + E+ N
Sbjct: 1184 AAVEQEKRN 1192
Score = 140 bits (352), Expect = 1e-32
Identities = 201/903 (22%), Positives = 412/903 (45%), Gaps = 116/903 (12%)
Query: 40 LIQKAKSRCTELEKEIEELRSK-PVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKE 98
L+QK+K + LEKE E+L +K EG ++ L E+ L + + ++ + +
Sbjct: 531 LLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSES 590
Query: 99 NIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEE 158
+ + ++ + D V + + + ++ + L ++L + K S+ ++ + E
Sbjct: 591 HKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTEL 650
Query: 159 AMNTQ-LELSEQLKFQNN---SEDNVKKLQEEIEKIRPGFEEQILYLQ------KQLDAT 208
++ + + +++ QN+ +++ ++ Q+E+ KI ++ LQ QL++
Sbjct: 651 LLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESH 710
Query: 209 TDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKEL--MCQIEASAKEH 266
E KE L E ++ + I L+ + L++KA ++ +++L Q+ +
Sbjct: 711 LKEYKEKYLSL----EQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELR 766
Query: 267 EAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQIC----SILLQE 322
E++K E+++ +V ++ ++QKK E LE++++ + ++ QI L QE
Sbjct: 767 ATELSKQLEMEKEIV---SSTRLDLQKKSEA-LESIKQKLTKQEEEKQILKQDFETLSQE 822
Query: 323 NTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHERE- 381
+ +N +++ L++++ + L E++ + + K+ ++ K EF E +
Sbjct: 823 TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQK 882
Query: 382 ------DLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQK 435
DLE EL K + +E E L K E ++ L ++
Sbjct: 883 GKAAILDLEKTCKEL---KHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQ 939
Query: 436 EISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELG 495
I N L +EKE+ L I LK+ E Q++KQ E+L+ ++I +
Sbjct: 940 LIQAQNT--LKQNEKEEQQLQGNINELKQSSE--QKKKQ-----IEALQGELKIAVLQKT 990
Query: 496 ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQG-----ENEKLLSQ 550
E K+ Q+ Q+ A++ ++K+ + ET +LQ E+E L ++
Sbjct: 991 ELENKLQQQLTQAAQELAAE----KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATR 1046
Query: 551 QELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELE-GKINSLTEEKDDFINKLKNSHEE 609
Q+L K+++EK LSL+Q D + + G N L +E K + E
Sbjct: 1047 QDL--------KSVEEK-----LSLAQEDLISNRNQIGNQNKLIQEL-----KTAKATLE 1088
Query: 610 MDNFHKKCEREERLILELGKKVEQTIQYNSELEQK--VNELTGGLEETLKEKDQNDQKLE 667
D+ K+ + +ER K Q IQ L++K VNE L E + K + ++++
Sbjct: 1089 QDSAKKEQQLQERC------KALQDIQKEKSLKEKELVNE-KSKLAEIEEIKCRQEKEIT 1141
Query: 668 KLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQL 727
KL ++E+ S +++S+ E N +++ + + LE L K D LK + Q
Sbjct: 1142 KL---------NEELKSHKLESIKEITNLKDAKQLLIQQKLE--LQGKAD-SLKAAVEQE 1189
Query: 728 EKKLQLMVEEQDNLNKLLENEQVQKLFV--KTQLYGFL--KEMGSEVSEDSEEKDVVNVL 783
++ Q++ +D + K E E+++K F+ + +L+ + KE+G + E++E K + +
Sbjct: 1190 KRNQQIL---KDQVKK--EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQI- 1243
Query: 784 QAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLL 843
A+ E+L + +E + +V ELEK+ L+ E V L++ +++ + E+ L
Sbjct: 1244 TALNENLGTVKKEWQS----SQRRVSELEKQTDDLRGEIAV----LEATVQNNQDERRAL 1295
Query: 844 RKELEEIQSEKEALQSDLLEMKNANEKT-----RLENQNLLIQVEEVSQTCSKSEIHNEK 898
+ + + E E LQ+ +LE++ + T L +N +Q++ K NE
Sbjct: 1296 LERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEV 1355
Query: 899 EKC 901
+ C
Sbjct: 1356 QNC 1358
Score = 99.8 bits (247), Expect = 2e-20
Identities = 172/780 (22%), Positives = 331/780 (42%), Gaps = 134/780 (17%)
Query: 27 KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDI------IKALTERL-- 78
+E+L ++Q ++ A+ R LE + EL S+ + E + IKA TE L
Sbjct: 595 QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ-LNESKEKVSQLDIQIKAKTELLLS 653
Query: 79 --------DALLLEKAETEQQCLSLKKENI-KMKQEVEDSVTKMGDAH----------KE 119
A L +T Q L K++ + K+ +++ K+ D KE
Sbjct: 654 AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE 713
Query: 120 LEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEA-----MNTQLEL-----SEQ 169
++ +++ ++ E L+ ++ + + E KA+ ++ L++ +NT LEL S+Q
Sbjct: 714 YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ 773
Query: 170 LKFQ----NNSEDNVKKLQEEIEKIRPGF---EEQILYLQKQLDATTDEKK--------- 213
L+ + +++ +++K E +E I+ EE+ L++ + + E K
Sbjct: 774 LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
Query: 214 --ETVTQLQNI------IEANSQHYQKNINSLQEELLQLKAIHQEE---VKELMCQIEAS 262
TVT+LQ + + + ++ + + L K+ ++E K + +E +
Sbjct: 834 IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKT 893
Query: 263 AKE--HEAEINKLNELKENL-VKQCEASEKNIQKKYECELENLRK---ATSNANQDNQIC 316
KE H+ ++ N LKE +K+ EK + + EL ++++ N + N+
Sbjct: 894 CKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
Query: 317 SILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEF 376
LQ N +NE + E K++E+ LK V L+ KL+ E
Sbjct: 954 EQQLQGN------INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007
Query: 377 FHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKE 436
E+E KI+ L E+ ++L+S+ G + T + + L +
Sbjct: 1008 AAEKE----KISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDL 1063
Query: 437 ISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGE 496
IS N+ + + K L L++ +Q+ QE + +++ + + EL
Sbjct: 1064 ISNRNQ--IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVN 1121
Query: 497 SAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPE 556
K++ E E +K +Q ++ +L ++L++ E ++ + L+ + ++LL QQ+L E
Sbjct: 1122 EKSKLA-EIEEIKCRQEKEITKLNEELKSHKLES---IKEITNLK-DAKQLLIQQKL--E 1174
Query: 557 LENTIKNL-----QEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMD 611
L+ +L QEK +L +D + KE E E K +FI K H E+
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQIL----KDQVKKEEE-------ELKKEFIEKEAKLHSEIK 1223
Query: 612 ----NFHKKCEREERLILELG---------KKVEQTIQYN-SELEQKVNELTGG---LEE 654
K E E +L +++ KK Q+ Q SELE++ ++L G LE
Sbjct: 1224 EKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEA 1283
Query: 655 TLKEKD-----------QNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQ 703
T++ + + ++EKL ++ L + +A V+ L EN L + Q
Sbjct: 1284 TVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQ 1343
Score = 65.1 bits (157), Expect = 6e-10
Identities = 103/427 (24%), Positives = 189/427 (44%), Gaps = 56/427 (13%)
Query: 35 KKQMMLIQK----AKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALL--LEKA-E 87
KKQ+ +Q A + TELE ++++ ++ E + A E++ L EK+ E
Sbjct: 972 KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQE-----LAAEKEKISVLQNNYEKSQE 1026
Query: 88 TEQQCLS----LKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRS 143
T +Q S + E + +Q+++ K+ A ++L S+ N + L EL ++
Sbjct: 1027 TFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLI-SNRNQIGNQNKLIQELKTAKA 1085
Query: 144 KYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQK 203
+D A ++QL+E ++ ++ + N K EIE+I+ E++I L +
Sbjct: 1086 TLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE 1145
Query: 204 QLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASA 263
+L + K E++ ++ N+ +A Q+ + LQ + LKA ++E + ++
Sbjct: 1146 ELKS---HKLESIKEITNLKDAKQLLIQQKL-ELQGKADSLKAAVEQEKRNQQI-LKDQV 1200
Query: 264 KEHEAEINKLNELKENLVKQCEASEKNI-QKKYECELENLRKATSNANQDNQICSILLQE 322
K+ E E+ K +++ E EK + KK+E EN K T N+ + +E
Sbjct: 1201 KKEEEELKK-EFIEKEAKLHSEIKEKEVGMKKHE---ENEAKLTMQITALNENLGTVKKE 1256
Query: 323 NTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHERED 382
Q +V LE +L + ++L E T NN + + + +K E E E
Sbjct: 1257 ----WQSSQRRVSELEKQTDDLRGEIAVL--EATVQNNQDERRALLERCLKGE--GEIEK 1308
Query: 383 LEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNE 442
L+ K+ EL KL + A V++ RE QSL+ +H + LN
Sbjct: 1309 LQTKVLELQ----------RKLDNTTA--------AVQELGRENQSLQIKHTQ---ALNR 1347
Query: 443 TFLSDSE 449
+ D+E
Sbjct: 1348 KWAEDNE 1354
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 197 bits (500), Expect = 9e-50
Identities = 356/1697 (20%), Positives = 701/1697 (41%), Gaps = 276/1697 (16%)
Query: 41 IQKAKSRCTELEKEIEELRSKPVT---EGTGDIIKALTERLDALLLEKAETEQQCLSLKK 97
I + + + LE E+ R T +GT + ++ +L ++ E + Q + +
Sbjct: 174 INRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQ 233
Query: 98 ENIKMKQEV-EDSVTKMGDAHKELEQSHINYVKEIENLKNE-----LMAVRSKYSEDKAN 151
+ + Q + +T++ H+E + ++E+ENL + + SK E +
Sbjct: 234 HEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKT 293
Query: 152 LQ----------KQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYL 201
+Q K++E+ + +++++L N D +++ QE++ + E+ L
Sbjct: 294 IQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENL 353
Query: 202 Q---KQLDATTDEKKETVTQLQNIIEANSQ-----HYQKNINSLQEELLQLKAIHQ---- 249
+ +L + ++ +T+T+ + I+ ++ Q+ ++ + E+++L +++Q
Sbjct: 354 KLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSL 413
Query: 250 -EEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSN 308
E+ +L +IE KE + EL+ +L+K + +YE AT +
Sbjct: 414 AEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLK--------LNNEYEVIKST---ATRD 462
Query: 309 ANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELE---------SQHSIL-KDEVTYM 358
+ D+++ + L EQ +N+ + E + E+E ++H IL KD+++
Sbjct: 463 ISLDSELHDLRLNLEA-KEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQ 521
Query: 359 NN------LKLK------------LEMDAQHIKDEFFHEREDL---EFKINELLLAKEEQ 397
N KLK LE D I E ++E L E +N+L L K++
Sbjct: 522 QNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKL 581
Query: 398 GCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF 457
+E L +L +++ ++++ N E++ Q+++E+S + + ++ +
Sbjct: 582 EDKVENLVDQL-NKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFK 640
Query: 458 EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVH 517
+ L +E++ + N + +E L L + A + E E + H
Sbjct: 641 D---------TLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRH 691
Query: 518 ELQQKL---RTAFTEKDALLETVNRLQGENEKLL--SQQELVPELENTIKNLQEKNGVYL 572
+L++ L EK+ ++ET+ +GE E L +++ L+ E K ++E L
Sbjct: 692 QLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEE-----L 746
Query: 573 LSLSQRDTMLKELEGK-INSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKV 631
+ +T +LE + + L ++KD I +LK + E+MD HK+ + LE K++
Sbjct: 747 SNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQL 806
Query: 632 EQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLY 691
Q I +K+ E + L+E E D+ Q L K + + + E L S+
Sbjct: 807 TQLINKKEIFIEKLKERSSKLQE---ELDKYSQALRKNEILRQTIEEKDRSLG----SMK 859
Query: 692 EENNKLSSEKKQL----SRDLEVFLSQKEDVI--LKEHITQLEKKLQLMVEEQDNLNKLL 745
EENN L E ++L SR V + D + L ++QL + + EE + K++
Sbjct: 860 EENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKII 919
Query: 746 ENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRD 805
E++ K+ QL L+E E+ E + + +N
Sbjct: 920 EDQNQSKM----QLLQSLQEQKKEMDEFRYQHEQMNATHT-------------------- 955
Query: 806 EKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMK 865
L LEK+ EE+KSL + EQ K L +E ++IQ++ SD+
Sbjct: 956 --QLFLEKD------------EEIKSLQKTIEQIKTQLHEERQDIQTD----NSDIF--- 994
Query: 866 NANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAEL 925
++T++++ N +E S+ S+ E+ IKE E LE K L ++ L
Sbjct: 995 ---QETKVQSLN----IENGSEKHDLSKAETERLVKGIKERE-----LEIKLLNEKNISL 1042
Query: 926 ILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSR 985
D L+K K + K+LE I+ L + + L +++L +
Sbjct: 1043 TKQIDQLSKDEVGKLTQIIQQKDLE--IQALHARISSTSHTQDVVYL-----QQQLQAYA 1095
Query: 986 KETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANN--F 1043
E + V L E L ++ + + L++ + ++++L E + F
Sbjct: 1096 MEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMF 1155
Query: 1044 EHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKEL 1103
I++L+R +R ++ + ++ + LLA ++T +
Sbjct: 1156 RETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGN--------------------- 1194
Query: 1104 EAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIA 1163
+ N+ EEL + K K+Q++K M+E K TT+ NM+
Sbjct: 1195 -----------EAGGVNSNQFEELLQERDKLKQQVKK-MEEW----KQQVMTTVQNMQ-H 1237
Query: 1164 DYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIK- 1222
+ +L +EL+Q L+ ++ + LQ + T L +Q YE+ TK+K
Sbjct: 1238 ESAQLQEELHQ-----------LQAQVLVDSDNNSKLQVDYTGL---IQSYEQNETKLKN 1283
Query: 1223 --QLLVKTKK---ELADSKQAETDHL-ILQASLKGELEASQQQVEVYKIQLAEITSEKHK 1276
Q L + + +L ++K L I+ L + Q E + +E+ SE +
Sbjct: 1284 FGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSE 1343
Query: 1277 I----HEHLKTSAEQHQRTLSAYQQRVTALQEECRAA----KAEQATVTSEFESYKVRVH 1328
+ E L+ S ++ T+ Q+ L + A + E SE + K +
Sbjct: 1344 LLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQD 1403
Query: 1329 NVLKQQKNKS-MSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINV----SELQTLQ 1383
+ K K K + +A+++ E+ +++ ++ L+ + NL+ + ++ L+
Sbjct: 1404 VLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENEL-LRQAVTNLKERILILEMDIGKLK 1462
Query: 1384 SEHDTLLERHN------KMLQETVSK-EAELREKLCSIQSENMMMKSEHTQTVSQLTSQN 1436
E++ ++E + + LQET K LREK + E MK E QL +
Sbjct: 1463 GENEKIVETYRGKETEYQALQETNMKFSMMLREK----EFECHSMK-EKALAFEQLLKEK 1517
Query: 1437 EVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRE 1496
E + +Q+ + + ++ QQ+ ++ L Q + E T + Q L++
Sbjct: 1518 EQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQ--NEVQRLRDKEF 1575
Query: 1497 RRNTDLPLLDMHTVTREEGEGMETTDTES-VSSASTYTQSLEQLLNSPETKLEPPLWHAE 1555
R N +L L H + E+ E E + LE+ L S +E A
Sbjct: 1576 RSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQAS 1635
Query: 1556 FTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRR----LERNQEREK 1611
E L ++L+ +K D ET ++ EQ+K + LE Q+ EK
Sbjct: 1636 VQVESLQEQLNVVSKQRD-------ETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEK 1688
Query: 1612 S--AANLEYLKNVLLQF 1626
+ +A LE K ++ ++
Sbjct: 1689 AMYSAELEKQKQLIAEW 1705
Score = 159 bits (402), Expect = 2e-38
Identities = 296/1479 (20%), Positives = 599/1479 (40%), Gaps = 215/1479 (14%)
Query: 315 ICSILLQENTFVEQVVNEKVKHLEDTL-----KELESQHSILKDEVTYM----NNLKLKL 365
+ S+ Q + F + ++ E + +E L KE+E+ H+IL+ E + +L+ K
Sbjct: 23 LASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKH 82
Query: 366 EMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNRE 425
E IK + R L+ K E+ K Q L+ +L L
Sbjct: 83 EASEIQIKQQSTSYRNQLQQKEVEISHLKARQ----IALQDQLLKLQSAAQSVPSGAGVP 138
Query: 426 VQSLKEQHQKEISELNETFLSDSEK--EKLTLMFEIQGLKEQCENLQQEKQEAILNYESL 483
+ IS F D + ++ EI L + L+ E + ++ +
Sbjct: 139 ATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESE----VGHWRHI 194
Query: 484 REIMEILQTELGESAG--KISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQ 541
+ + T+ + + K+ + +KQ ++ ++ + Q ++ L ++R
Sbjct: 195 AQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISR-- 252
Query: 542 GENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFIN 601
E+L +E + ELEN ++ Q +GV LS+ + E++ I L EK +
Sbjct: 253 RHREELSDYEERIEELENLLQ--QGGSGVIETDLSK----IYEMQKTIQVLQIEKVESTK 306
Query: 602 KLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQ 661
K++ +++ + +KK E L ++ E Q N E Q + E E K +
Sbjct: 307 KMEQLEDKIKDINKKLSSAENDRDILRREQE---QLNVEKRQIMEECENLKLECSKLQPS 363
Query: 662 NDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILK 721
++ + + + ++L++ SA V+ ++ LS + ++ R S +D L
Sbjct: 364 AVKQSDTMTEKERILAQ-----SASVEEVFRLQQALSDAENEIMR----LSSLNQDNSLA 414
Query: 722 EHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVN 781
E +L+ +++++ +E+ L++ E Q+ L + + ++S DSE D+
Sbjct: 415 EDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRL 474
Query: 782 VLQAVGESLAKINEEKCNLAFQRDE----------KVLELEKEIKCLQEESVVQCEELKS 831
L+A + L + EK L + +E ++ ++ ++ Q E +LK
Sbjct: 475 NLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQ 534
Query: 832 LLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSK 891
L D ++ L + +I E + + L++ + A L Q L +VE + +K
Sbjct: 535 DLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNK 594
Query: 892 SEIHN---EKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKS---PSVKNDPLSS 945
S+ N +KE +KEH +R EL +++ L +S S N +
Sbjct: 595 SQESNVSIQKENLELKEH-----------IRQNEEELSRIRNELMQSLNQDSNSNFKDTL 643
Query: 946 VKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQL 1005
+KE E ++ NL++ E E+ +K VA K E + + V+ +LE + +QL
Sbjct: 644 LKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQL 703
Query: 1006 SASMRDLIQGAESYKNLLLEYEKQSEQLDVEK---ERANNFEHRIEDLT--RQLRNSTLQ 1060
S +++ + K E ++E +K E AN +E IE+L+ R L S LQ
Sbjct: 704 SLEKNTIVETLKMEKG-----EIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQ 758
Query: 1061 CE-----TINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIK 1115
E +N + +A ++ K +E + + K ++ LE +K Q Q I
Sbjct: 759 LEHEHLIKLNQKKDMEIAELK------KNIEQMDTDHKETKDVLSSSLEEQK-QLTQLIN 811
Query: 1116 EHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQK 1175
+ + +L+E +LQ+E + + +++ E++++ ++ + + ++E ++
Sbjct: 812 KKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELER 871
Query: 1176 LTNKNNK------------IEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQ 1223
L + ++ + +L E+ +E L+EEI Q ++ + ++ Q
Sbjct: 872 LREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQ 931
Query: 1224 LLVKTKKELAD----SKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHE 1279
L + KKE+ + +Q H L E+++ Q+ +E K QL H+ +
Sbjct: 932 SLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQL-------HEERQ 984
Query: 1280 HLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSM 1339
++T + + E+ +KAE + + ++ + L +KN S+
Sbjct: 985 DIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIK--LLNEKNISL 1042
Query: 1340 SQAETEGAKQEREHLEMLIDQLKIKLQ------DSQNNLQINVSELQTLQS--------- 1384
++ + +K E L +I Q +++Q S ++ Q V Q LQ+
Sbjct: 1043 TKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVF 1102
Query: 1385 --------EHDTLLERHNKMLQETVSKEAEL------REKLCS-IQSENMMMKSEHTQTV 1429
E+ L ++KM+ +KEA L +KL + +S M E Q +
Sbjct: 1103 AVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNL 1162
Query: 1430 SQLTSQNEV--------------------------------------LRNSFRDQVRHLQ 1451
S++ + ++ R+ + QV+ ++
Sbjct: 1163 SRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKME 1222
Query: 1452 EEHRK---TVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ-----QSLKNLRERRNTDLP 1503
E ++ TV+ +Q + ++++ +L QL+ + S +S+ L E+ T L
Sbjct: 1223 EWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLK 1282
Query: 1504 LL--DMHTVTREEGEGMETTD---------TESVSSASTYTQSLEQLLNSPETKLEPPLW 1552
++ V G+ T D + +SSAS T + L + ++++
Sbjct: 1283 NFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEV----- 1337
Query: 1553 HAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKS 1612
+ E L Q+L KS + +R + N L + I SE+ R +E E++
Sbjct: 1338 -LSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSI-AATSELER----KEHEQT 1391
Query: 1613 AANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPE 1651
+ ++ LK Q + K E++ L+ + L S E
Sbjct: 1392 DSEIKQLKE--KQDVLQKLLKEKDLLIKAKSDQLLSSNE 1428
Score = 144 bits (364), Expect = 6e-34
Identities = 265/1334 (19%), Positives = 546/1334 (40%), Gaps = 228/1334 (17%)
Query: 27 KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKA-LTERLDALLLEK 85
K+DL K+ L EL+ + E+L V + K L ++++ L+ +
Sbjct: 533 KQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL 592
Query: 86 AETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQS-----HINYVK--------EIE 132
++++ +S++KEN+++K+ + + ++ EL QS + N+ E+
Sbjct: 593 NKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVR 652
Query: 133 NLKNELMAVRS------KYSED-KANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQE 185
NLK L + K + D K +K + + + +L E L N + E
Sbjct: 653 NLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVE 712
Query: 186 EIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLK 245
++ + E ++ + +K+L ++ ++T+ +L N N+ Q E L++L
Sbjct: 713 TLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLE----HEHLIKLN 768
Query: 246 AIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQ--KKYECELENLR 303
E+ EL IE +H+ E K+ L E ++ Q K E +E L+
Sbjct: 769 QKKDMEIAELKKNIEQMDTDHK-------ETKDVLSSSLEEQKQLTQLINKKEIFIEKLK 821
Query: 304 KATSNANQDNQICSILLQENTFVEQVVNEKVK----------HLEDTLKELESQHSI--- 350
+ +S ++ S L++N + Q + EK + HL++ L+ L + S
Sbjct: 822 ERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAP 881
Query: 351 ------------LKDEVTYMNNLKLKLEMDAQHIK------------------------D 374
L EV+ +N +K LE + +H + D
Sbjct: 882 VADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMD 941
Query: 375 EFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREV-QSLKEQH 433
EF ++ E + +L L K+E+ ++K ++ + ++ N ++ Q K Q
Sbjct: 942 EFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQS 1001
Query: 434 QKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESL---REIMEIL 490
+ + LS +E E+L ++G+KE+ E + +LN +++ ++I ++
Sbjct: 1002 LNIENGSEKHDLSKAETERL-----VKGIKER------ELEIKLLNEKNISLTKQIDQLS 1050
Query: 491 QTELGESAGKISQ---EFESMKQQQAS-----DVHELQQKLRTAFTEKDALLETVNRLQG 542
+ E+G+ I Q E +++ + +S DV LQQ+L+ E++ + +N
Sbjct: 1051 KDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTR 1110
Query: 543 ENEKLLSQ----QELVPELENTIKNLQEKN------------GVYLLSLSQRDTMLKELE 586
EN L ++ ++V E + LQ++N ++ ++ +++E +
Sbjct: 1111 ENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKD 1170
Query: 587 GKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVN 646
+I++L+++ + L+ S + + E L+ E K ++Q ++ E +Q+V
Sbjct: 1171 IEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDK-LKQQVKKMEEWKQQVM 1229
Query: 647 ELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSR 706
++ E Q ++L +L Q+ V S++ L + L + + ++ K +
Sbjct: 1230 TTVQNMQH---ESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQ 1286
Query: 707 DLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEM 766
+L ++ I QL L++ + D ++ L + + + Q L+
Sbjct: 1287 ELAQ---------VQHSIGQLCNTKDLLLGKLDIISPQLSSASL----LTPQSAECLRAS 1333
Query: 767 GSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQC 826
SEV +S E +LQ E L K +EK E L I E +
Sbjct: 1334 KSEVLSESSE-----LLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEH 1388
Query: 827 EELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVS 886
E+ S ++ ++++ +L+K L+E +A +SD L N N ++ LL Q
Sbjct: 1389 EQTDSEIKQLKEKQDVLQKLLKEKDLLIKA-KSDQLLSSNENFTNKVNENELLRQA---- 1443
Query: 887 QTCSKSEIHNEKEKCFIKEHENLKPLLEQKEL----RDRRAELILLKDSLAKSPSVKNDP 942
+ N KE+ I E + K E +++ R + E L+++ K + +
Sbjct: 1444 -------VTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREK 1496
Query: 943 LSSVKELEEKIENLEKECKEKEE----KINKIKLVAVKAKKE---------------LDS 983
++EK E+ KEKE+ ++N++ L AVK+ +E L
Sbjct: 1497 EFECHSMKEKALAFEQLLKEKEQGKTGELNQL-LNAVKSMQEKTVVFQQERDQVMLALKQ 1555
Query: 984 SRKETQTVKEELESLRSEK----DQLSASMRDLIQGAESYKNLLLEYE----KQSEQLDV 1035
+ E ++ E++ LR ++ +L L++ +SY L E K +++ V
Sbjct: 1556 KQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTV 1615
Query: 1036 EKER----ANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILE 1091
+E+ +N E+ + Q+ + Q ++ ++ ++ Q K + +
Sbjct: 1616 LEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLAN 1675
Query: 1092 VQRA--------KAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQ 1143
+Q KAM ELE +K Q I E LE + LQ+ +
Sbjct: 1676 LQMVLEHFQQEEKAMYSAELEKQK----QLIAEWKKNAENLEGKVI-------SLQECLD 1724
Query: 1144 ELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEE 1203
E A + L ++L K +IE+L+++ +++++ + +Q++
Sbjct: 1725 EANAALDSASR-----------------LTEQLDVKEEQIEELKRQNELRQEMLDDVQKK 1767
Query: 1204 ITSLQSSVQQYEEK 1217
+ SL +S + +K
Sbjct: 1768 LMSLANSSEGKVDK 1781
Score = 85.5 bits (210), Expect = 4e-16
Identities = 165/844 (19%), Positives = 350/844 (41%), Gaps = 113/844 (13%)
Query: 16 GTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPV------------ 63
G+ K L E L+K K++ + I+ + L K+I++L V
Sbjct: 1007 GSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDL 1066
Query: 64 -----------TEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEV------ 106
T T D++ L ++L A +E+ + +EN +K E
Sbjct: 1067 EIQALHARISSTSHTQDVV-YLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDI 1125
Query: 107 ----EDSVTKMGDAHKELEQSHINYVKEI--ENLKNELMAVRSKYSEDKANLQK--QLEE 158
E ++ K+ D +K+L + +++ E ++N +R K E A QK L
Sbjct: 1126 VAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLA 1185
Query: 159 AMNTQLELSEQLKFQNNSEDNV----KKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKE 214
+ T +E +N + + KL+++++K+ +++Q++ + + + + +E
Sbjct: 1186 VLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEE-WKQQVMTTVQNMQHESAQLQE 1244
Query: 215 TVTQLQNIIEANSQH-------YQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHE 267
+ QLQ + +S + Y I S ++ +LK Q E+ ++ I +
Sbjct: 1245 ELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQ-ELAQVQHSIGQLCNTKD 1303
Query: 268 AEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVE 327
+ KL+ + L + ++ + + E L +++ Q+ + LQE
Sbjct: 1304 LLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATI 1363
Query: 328 QVVNEKVKHLEDTL-----------KELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEF 376
+ + E L D++ ++ +S+ LK++ + L + ++ + D+
Sbjct: 1364 RTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQL 1423
Query: 377 FHEREDLEFKINELLLAKE------EQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLK 430
E+ K+NE L ++ E+ ++E +L G N++ T E Q+L+
Sbjct: 1424 LSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQ 1483
Query: 431 EQHQKEISELNE-TFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEI 489
E + K L E F S KEK L FE Q LKE+ + E + + +S++E +
Sbjct: 1484 ETNMKFSMMLREKEFECHSMKEK-ALAFE-QLLKEKEQGKTGELNQLLNAVKSMQEKTVV 1541
Query: 490 LQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLS 549
Q E + + Q KQ + + + Q+LR + LE + E+E +
Sbjct: 1542 FQQERDQVMLALKQ-----KQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYT 1596
Query: 550 QQELVPE-----LENTIKNLQEK----NGVYLLSLSQRDTMLKELEGKINSLTEEKDDFI 600
++ L E L + L+EK + + Q ++ L+ ++N +++++D+
Sbjct: 1597 REALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656
Query: 601 NKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKD 660
+L S E++ + + ++LE ++ E+ Y++ELE++ ++ + E
Sbjct: 1657 LQLSVSQEQVKQYALSLANLQ-MVLEHFQQ-EEKAMYSAELEKQ--------KQLIAEWK 1706
Query: 661 QNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVIL 720
+N + LE ++ ++ ++ L E+ + + ++L R E+ +DV
Sbjct: 1707 KNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDV-- 1764
Query: 721 KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFV------KTQLYGFLKEMGSEVSEDS 774
+K + L + ++K+L ++ LF+ K Q + L+ MGS +
Sbjct: 1765 ------QKKLMSLANSSEGKVDKVL----MRNLFIGHFHTPKNQRHEVLRLMGSILGVRR 1814
Query: 775 EEKD 778
EE +
Sbjct: 1815 EEME 1818
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 197 bits (500), Expect = 9e-50
Identities = 346/1668 (20%), Positives = 692/1668 (41%), Gaps = 214/1668 (12%)
Query: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146
E E+ C L+ E ++ E+ DS ++ A +++ + + E++ L ++ + +
Sbjct: 1302 ELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELV 1361
Query: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
ED + E N Q +S ++NS +++ +E++ +E+ L LQ +
Sbjct: 1362 EDIPG--GEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHK 1419
Query: 207 ATTDEKKETVTQLQNI------IEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIE 260
D+ + +++ + ++A + N+ + Q +L++ + EE L+ +
Sbjct: 1420 ILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEE--GLVPSLS 1477
Query: 261 ASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQ---DNQICS 317
+S + ++ L + + + ++ L NL A S ANQ D CS
Sbjct: 1478 SSCVPDSSSLSSLGDSSFYRALLEQTGDMSL-------LSNLEGAVS-ANQCSVDEVFCS 1529
Query: 318 ILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFF 377
L +EN ++ + K +E ELES + + + KL+ +M++Q I
Sbjct: 1530 SLQEENLTRKETPSAPAKGVE----ELESLCEVYRQSLE-----KLEEKMESQGIM---- 1576
Query: 378 HEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQF-----CYTVEQHNREVQSLKEQ 432
++ E + E LL+ E Q ++ L+ + N+Q+ T+E ++ K+
Sbjct: 1577 ---KNKEIQELEQLLSSERQE--LDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQT 1631
Query: 433 HQK----EISELNETFLSDSEKEKLTLMFE--IQGLKEQCENLQQE-------------- 472
Q E++ L L S + L + E IQG E C+ ++
Sbjct: 1632 EQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVH 1691
Query: 473 -------KQEAILNYESLREIMEILQTELGESAGKISQEF------ESMKQQQASDVHEL 519
+Q+ L+ E + E + T GE +G+ S + E Q + + EL
Sbjct: 1692 QICDKDAQQDLNLDIEKITETGAVKPT--GECSGEQSPDTNYEPPGEDKTQGSSECISEL 1749
Query: 520 QQKLRTAFTEKDAL--LETVNRLQ-------GENEKLL----SQQELVPELENTIKNLQE 566
A D L E ++ LQ EN +LL + V L N +K L
Sbjct: 1750 SFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDS 1809
Query: 567 KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILE 626
K + + L + ELE + L +E D KL+ + ++ E E L +
Sbjct: 1810 KLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSD 1869
Query: 627 LGKKVEQT---------IQYNSELEQKVNELTGGLEETLKEKDQNDQK-------LEKLM 670
L +++ + N +++ ++ L EK + + LE +
Sbjct: 1870 LEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQ 1929
Query: 671 VQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKK 730
+ L +D E + L EE + ++SE+ QL +L+ K+ L + ++++K
Sbjct: 1930 TEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTM--SKKTTALDQLSEKMKEK 1987
Query: 731 LQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKD-VVNVLQAVGES 789
Q E + + ++ L QV + VK + L+ + S+VSE ++K + LQ++ +
Sbjct: 1988 TQ---ELESHQSECLHCIQVAEAEVKEKTE-LLQTLSSDVSELLKDKTHLQEKLQSLEKD 2043
Query: 790 LAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEE 849
++ KC L + ++ +L KE + L +ES E L++ L + + EK+ + K LE
Sbjct: 2044 SQALSLTKCEL----ENQIAQLNKEKELLVKES----ESLQARLSESDYEKLNVSKALEA 2095
Query: 850 IQSEK-------EALQSDLLEMKNANEKTRL---------------------ENQNLLIQ 881
EK + Q ++ +++ EK R+ EN +L +
Sbjct: 2096 ALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDK 2155
Query: 882 VEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQ---------KELRDRRAELILL---K 929
VE + + SE E ++ I + EN K +E + L+ +L+ L K
Sbjct: 2156 VENLERELQMSE---ENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEK 2212
Query: 930 DSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAK----KELDSS- 984
++L K K LS + +L ++L +E ++ E +I + AV+ KEL+ +
Sbjct: 2213 ENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAV 2272
Query: 985 ------RKETQTVKEELESLRSEKDQLSASMRDL---IQGAESYKNLLLEYEKQSEQ-LD 1034
++ + ++ L+ E+ QL S+ L ++ E + +L+ K+SE D
Sbjct: 2273 AALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHAD 2332
Query: 1035 VEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQR 1094
+ K R N E +E ++ L+ E + E L A+IE + + + LE+ ++ ++
Sbjct: 2333 LLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRS 2392
Query: 1095 AKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQL-QKTMQELELVKKDAQ 1153
K + EL+ E +++I E + E + + ++EK Q+ +K+ +E+++ +
Sbjct: 2393 EKENLTNELQKE----QERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLK 2448
Query: 1154 QTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQ 1213
+ +N +A + K N ++++E LE E Q + + LQSSV
Sbjct: 2449 E---LNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNG 2505
Query: 1214 YEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSE 1273
++ KQ L K +E++ K D L + L ++E Q + ++L +T E
Sbjct: 2506 LIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKL-SQVEGEHQLWKEQNLELRNLTVE 2564
Query: 1274 KHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQ 1333
+ + L++ Q TL Q L+ E K ++ + + K+ Q
Sbjct: 2565 LEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVN--KMTAKETELQ 2622
Query: 1334 QKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERH 1393
++ M+Q E ++ L +L++ L++ ++ + +L+ L E+ L +
Sbjct: 2623 REMHEMAQKTAELQEELSGEKNRLAGELQLLLEE----IKSSKDQLKELTLENSELKKSL 2678
Query: 1394 NKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEE 1453
+ M ++ V KE ++RE++ Q + +H + Q EV ++R+++ +
Sbjct: 2679 DCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKE-- 2736
Query: 1454 HRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTRE 1513
E L Q K+E L + E S ++ Q L+ L++ + +L ++ E
Sbjct: 2737 -----ECLSSQ--KLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENE 2789
Query: 1514 EGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHA-------EFTKE--ELVQK 1564
+G +S + L++ L+ + E E T E EL +
Sbjct: 2790 RAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKET 2849
Query: 1565 LSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKS 1612
L TK AD ++ L + ++L++++ L Q ++ S
Sbjct: 2850 LEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDS 2897
Score = 183 bits (464), Expect = 1e-45
Identities = 369/1686 (21%), Positives = 696/1686 (41%), Gaps = 288/1686 (17%)
Query: 71 IKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKE 130
I+ L +LD L EK + + Q SL+ K KQ+VE+ T+ G K Q + +
Sbjct: 20 IQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTE-GTNLKRENQRLMEICES 78
Query: 131 IENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKI 190
+E K ++ + + E + N Q+ + Q+E EQ +K+ + E+E+
Sbjct: 79 LEKTKQKI-SHELQVKESQVNFQEGQLNSGKKQIEKLEQ---------ELKRCKSELERS 128
Query: 191 RPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQH------YQKNINSLQEELLQL 244
+ + + L T +K T + + S++ Y K + + ++
Sbjct: 129 QQAAQSADVSLN---PCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEV 185
Query: 245 KAIHQEEVKELMCQIEASAKE---HEAEINKLNELKENLVKQCEASEKN--IQKKYECEL 299
KA+ ++ + + Q + ++ H+A + + +E ++ + I++ +
Sbjct: 186 KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASY 245
Query: 300 ENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMN 359
+ + + + QI + F N HL D LK +Q+ L++++ N
Sbjct: 246 FSGEQEVTPSRSTLQIGKRDANSSFF----DNSSSPHLLDQLK---AQNQELRNKI---N 295
Query: 360 NLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTV 419
L+L+L+ + +K + ++ ++L+ ++ + + E+ V+ K + EL Q+
Sbjct: 296 ELELRLQGHEKEMKGQ-VNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQAS 354
Query: 420 EQHNREVQSLKE-----QHQKEISELNETFLSDSEKEK-LTLMFEIQGLKEQCENLQQE- 472
++ Q LK+ Q++ +E L KEK E+ + + L QE
Sbjct: 355 TKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQEC 414
Query: 473 ---KQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKL------ 523
K + + + +LQ EL + S+KQQ +++ E +QKL
Sbjct: 415 IQMKARLTQELQQAKNMHNVLQAEL--------DKLTSVKQQLENNLEEFKQKLCRAEQA 466
Query: 524 -RTAFTEKDALLETVNRLQGENEKLLSQQEL----VPELENTIKNL-----QEKNGVYLL 573
+ + +++ L ++ ++ EN L S E V LE +KN+ Q +N +
Sbjct: 467 FQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEM 526
Query: 574 SL--SQRDTMLKELEGKI----NSLTEEK---------------DDFINKLKNSHEEMDN 612
+ ++TML++L+ KI NSLT EK D + K ++ E++++
Sbjct: 527 KAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLND 586
Query: 613 FHKKCEREERLI---LELGK------KVEQTI-------------QYNSE---LEQKVNE 647
K E+E + + LEL K K E+T+ Q SE L+ K+N
Sbjct: 587 KLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINH 646
Query: 648 LTGGLE-ETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSR 706
L L+ + +K + N+ +++ L D+E LS E+++L+ N L S+ ++
Sbjct: 647 LETCLKTQQIKSHEYNE--------RVRTLEMDRENLSVEIRNLH---NVLDSKSVEVET 695
Query: 707 DLEVF--LSQKEDVILKEHITQLE------KKLQLMVEEQDNLNKLLENEQVQKLFVKTQ 758
+ L QK + ++H ++E +L VE+ ++ +LL NE + K
Sbjct: 696 QKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQD 755
Query: 759 L---YGFLKEM-----GSEVSEDSEEKDVVNVLQ--AVGESLAKINEEKCNLAFQRDEKV 808
L Y L+++ S V+ + ++ ++ Q A+ S A I E+ ++ +R E
Sbjct: 756 LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECR 815
Query: 809 LELEKEIKCLQEESVVQ--CEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKN 866
LE ++ K +++Q + L+ L +Q L+K+ EE+ K ++ +L++ +
Sbjct: 816 LEADQSPK---NSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQ 872
Query: 867 ANEKTRLENQNLLIQVEE--------VSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKEL 918
++ E + +++E V++T S E + EKE + N K EQ E+
Sbjct: 873 MHQSFVAETSQRISKLQEDTSAHQNVVAETLSALE-NKEKELQLL----NDKVETEQAEI 927
Query: 919 RDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAK 978
++ + LL+DSL KEL+ E L E KE I+ K
Sbjct: 928 QELKKSNHLLEDSL--------------KELQLLSETLSLEKKEMSSIIS-------LNK 966
Query: 979 KELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKE 1038
+E++ +E T+KE SL EK +LIQ +ES+ N + E EK +L
Sbjct: 967 REIEELTQENGTLKEINASLNQEK-------MNLIQKSESFANYIDEREKSISEL----- 1014
Query: 1039 RANNFEHRIEDLTRQLRNSTLQ-CETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKA 1097
D +Q + LQ CE + EDL + + Q LE + E
Sbjct: 1015 ---------SDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNEC--TSL 1063
Query: 1098 MVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTL 1157
+++ E E+L KE KEH + +L + + Q +L+ Q L D Q +
Sbjct: 1064 CENRKNELEQL-KEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSK 1122
Query: 1158 MNMEIADYE--RLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYE 1215
E L +E N+ N+ +++ EQ +K+ K K E E +++SV++ E
Sbjct: 1123 SEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERE 1182
Query: 1216 EK----------------------NTKIKQLLVKTKKELADSKQAETDHLILQ---ASLK 1250
+ N ++ QL + + +++E + LQ +++
Sbjct: 1183 SERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIR 1242
Query: 1251 GELEAS----QQQVEVYKIQLAEITSEKHKIHEHLKTSAEQH-----QRTLSAYQQRVTA 1301
G+LE S Q E+ ++ EI +E+ I + S Q+ Q +L ++
Sbjct: 1243 GDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNE 1302
Query: 1302 LQEECRAAKAEQATVTSEFESYK---VRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLI 1358
L++ C +AE+ + +E + + + ++ K +++ + H E++
Sbjct: 1303 LEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVE 1362
Query: 1359 DQLKIKLQDSQNNLQ-INVSELQTLQS-EHDTLLERHNKMLQETVSKEAELREKLCSIQS 1416
D + + N ++++ L S EH TL ++ +M AEL+EK S+QS
Sbjct: 1363 DIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQM------HFAELQEKFLSLQS 1416
Query: 1417 ENMMMKSEHTQT----------VSQLTSQNEVLRNSFRDQVRHLQEEHRKTVE-----TL 1461
E+ ++ +H Q V L ++N VL + R+ L +E + +E +L
Sbjct: 1417 EHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSL 1476
Query: 1462 QQQLSKMEAQLFQLKNEPTTRS---PVSSQQSLKNLRERRNTD--------LPLLDMHTV 1510
+ L L + R+ L NL + + L +
Sbjct: 1477 SSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENL 1536
Query: 1511 TREEGEGMETTDTESVSS-ASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTT 1569
TR+E E + S Y QSLE+L E K+E +EL Q LSS
Sbjct: 1537 TRKETPSAPAKGVEELESLCEVYRQSLEKL----EEKMESQGIMKNKEIQELEQLLSSER 1592
Query: 1570 KSADHL 1575
+ D L
Sbjct: 1593 QELDCL 1598
Score = 167 bits (422), Expect = 1e-40
Identities = 316/1535 (20%), Positives = 619/1535 (40%), Gaps = 232/1535 (15%)
Query: 27 KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKA 86
K + KF + Q+ L +KAK E EK + + R D + T + D +
Sbjct: 309 KGQVNKFQELQLQL-EKAKVELIEKEKVLNKCR---------DELVRTTAQYDQASTKYT 358
Query: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146
EQ+ L ++ +Q E + + KE E+ + +E+ + + +
Sbjct: 359 ALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKE---FQEELSRQQRSFQTLDQECI 415
Query: 147 EDKANLQKQLEEAMNT----QLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQ 202
+ KA L ++L++A N Q EL + + E+N+++ ++++ + F+ +
Sbjct: 416 QMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKEN 475
Query: 203 KQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEAS 262
+ + + KKE N+++++S+ + + L+ EL + +K+ + Q +
Sbjct: 476 ELRRSMEEMKKEN-----NLLKSHSEQKAREVCHLEAEL--------KNIKQCLNQSQNF 522
Query: 263 AKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQE 322
A+E +A+ N +E +++ + EK Q++ LE L+ A ++ + LL++
Sbjct: 523 AEEMKAK----NTSQETMLRDLQ--EKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKK 576
Query: 323 NTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKL---EMDAQHIKDEFFHE 379
+ +N+K+ E K L S + K E + K + + + + + E
Sbjct: 577 REHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESE 636
Query: 380 REDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSL---KEQHQKE 436
+E+L+ KIN L + Q ++KS ++N V++L +E E
Sbjct: 637 KENLQSKINHLETCLKTQ-----QIKSH-------------EYNERVRTLEMDRENLSVE 678
Query: 437 ISELNETFLSDS---EKEKLTLM-------FEIQGLKEQCENLQQEKQEAILNYESLREI 486
I L+ S S E +KL M F Q +++ EN+ + + E L
Sbjct: 679 IRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHK 738
Query: 487 MEILQTELGESAG---KISQEFESM----KQQQASDV-HELQQKLRTAFTEKDALLETVN 538
+++L E+ + + E+ES+ K + AS V +E Q+ AF ++ A+ +
Sbjct: 739 LQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFA 798
Query: 539 RLQGENEKLLSQQ-ELVPELENTIKN---LQEKNGVYLLSLSQRDTMLKELEGKINSLTE 594
+ GE + S++ E E + + KN LQ + SL + M +L+ + L +
Sbjct: 799 NIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQ 858
Query: 595 EKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEE 654
K + L + + +F + E +++ + + S + V E LE
Sbjct: 859 IKGEIEENLMKAEQMHQSF----------VAETSQRISKLQEDTSAHQNVVAETLSALEN 908
Query: 655 TLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQ 714
KE + K+E +++ L + +L +K L + LS EKK++S +
Sbjct: 909 KEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMS---SIISLN 965
Query: 715 KEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSE-- 772
K ++ E +TQ L+ +N L E++ + ++ E +SE
Sbjct: 966 KREI---EELTQENGTLK-------EINASLNQEKMNLIQKSESFANYIDEREKSISELS 1015
Query: 773 DSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSL 832
D +++ + +LQ E+ + Q+ + E +++CL E CE K+
Sbjct: 1016 DQYKQEKLILLQRCEETGNAYED-----LSQKYKAAQEKNSKLECLLNECTSLCENRKN- 1069
Query: 833 LRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTC--- 889
+ EQ K KE +E L ++ A E+ NQNL++++E V Q
Sbjct: 1070 --ELEQLKEAFAKEHQEF----------LTKLAFAEER----NQNLMLELETVQQALRSE 1113
Query: 890 -------SKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDP 942
SKSE K++ + E K E +L +L+ + + + +++++P
Sbjct: 1114 MTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEP 1173
Query: 943 L-SSVKELEEKIE------NLEKECKEKEEKINKIKLVAVKA-----KKELDSSRKETQT 990
+ +SVKE E + ++ E KE +LV ++A + +L S KE +
Sbjct: 1174 IRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKEC 1233
Query: 991 VKEELESLRSEKD-------------------------------QLSASMRD---LIQGA 1016
++ EL+++R + + +LS S D L
Sbjct: 1234 LQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSL 1293
Query: 1017 ESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNED----LL 1072
++ N L E EK E L EK +L +L +S +C T + LL
Sbjct: 1294 QTTMNKLNELEKICEILQAEK----------YELVTELNDSRSECITATRKMAEEVGKLL 1343
Query: 1073 ARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQ----KEQKIKEHATTVNELEELQ 1128
++ L ++ LL +++E ++ E + E EH T + +E+Q
Sbjct: 1344 NEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSD--KEVQ 1401
Query: 1129 VQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKL-TNKNNKIEDLE 1187
+ + +++ E +++ Q + E+ Y +K N L TN N DL
Sbjct: 1402 MHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLV 1461
Query: 1188 QEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQA 1247
+E+++ + + + SL SS + + + +T + L +
Sbjct: 1462 KEMQLGLE-----EGLVPSLSSSCVPDSSSLSSLGD------SSFYRALLEQTGDMSLLS 1510
Query: 1248 SLKGELEASQQQV-EVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEEC 1306
+L+G + A+Q V EV+ L E + + E+ + Y+Q + L+E+
Sbjct: 1511 NLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKM 1570
Query: 1307 RAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQ 1366
+ + E E L + + +S+ E K LEM K Q
Sbjct: 1571 ESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQ 1630
Query: 1367 DSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA-ELREKLCSIQSENMMMKSEH 1425
Q +L++ V+ LQ LQ L+ ++ L +++A + R + C I EH
Sbjct: 1631 TEQLSLELEVARLQ-LQG-----LDLSSRSLLGIDTEDAIQGRNESCDI-------SKEH 1677
Query: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVET 1460
T ++ T +++V + +D + L + K ET
Sbjct: 1678 TSETTERTPKHDVHQICDKDAQQDLNLDIEKITET 1712
Score = 166 bits (420), Expect = 2e-40
Identities = 247/1017 (24%), Positives = 464/1017 (45%), Gaps = 153/1017 (15%)
Query: 40 LIQKAKSRCTELEKEIEE------LRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCL 93
L +K K + ELE E + V E T ++++ L+ + LL +K +++
Sbjct: 1980 LSEKMKEKTQELESHQSECLHCIQVAEAEVKEKT-ELLQTLSSDVSELLKDKTHLQEKLQ 2038
Query: 94 SLKKENIKM---KQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKA 150
SL+K++ + K E+E+ + ++ + KEL VKE E+L+ L S+ +K
Sbjct: 2039 SLEKDSQALSLTKCELENQIAQL-NKEKEL------LVKESESLQARL----SESDYEKL 2087
Query: 151 NLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTD 210
N+ K LE A+ + E + +L QEE+ ++R G E+ L+ +++A D
Sbjct: 2088 NVSKALEAALVEKGEFALRLS----------STQEEVHQLRRGIEK----LRVRIEA--D 2131
Query: 211 EKKET-VTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQE-----------EVKELMCQ 258
EKK+ + + E + + + +L+ E LQ+ +QE EV+ L Q
Sbjct: 2132 EKKQLHIAEKLKERERENDSLKDKVENLERE-LQMSEENQELVILDAENSKAEVETLKTQ 2190
Query: 259 IE---ASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQI 315
IE S K E ++ L KENL KQ + + + EL+ L + + ++ +
Sbjct: 2191 IEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLS-----ELDKLLSSFKSLLEEKEQ 2245
Query: 316 CSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDE 375
I ++E + V+ L++ LKEL + L + M + L+ I++E
Sbjct: 2246 AEIQIKEES------KTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD---PPIEEE 2296
Query: 376 FFHEREDLEFKINELLLAKE-EQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQ 434
H+ + K+ L A E +Q CV+++LK E H ++ E +
Sbjct: 2297 --HQLRNSIEKLRARLEADEKKQLCVLQQLKES------------EHHADLLKGRVENLE 2342
Query: 435 KEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTEL 494
+E+ E+ T + E E++ LK + E + Q + L+ ++R E L EL
Sbjct: 2343 REL-EIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNEL 2401
Query: 495 GESAGKISQ------EFESMKQQQASDVHELQQKLRTAF----TEKDALLETVNRLQGEN 544
+ +IS+ FE++ Q++ + ++++K TA T+ L E V L +
Sbjct: 2402 QKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQ 2461
Query: 545 EKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLK 604
E ++++ L + ++ L+ + L L + L+ +N L +E +D KL+
Sbjct: 2462 EACKAKEQ---NLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLE 2518
Query: 605 NSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLE---ETLKEKDQ 661
EE+ + + +E+L+ +L +VE Q E ++ LT LE + L+ K+
Sbjct: 2519 KKDEEISRLKNQIQDQEQLVSKL-SQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNA 2577
Query: 662 NDQ-KLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVIL 720
+ Q LE L K L + E+ + S E+ NK+++++ +L R++ ++QK +
Sbjct: 2578 SLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHE-MAQKTAELQ 2636
Query: 721 KE---HITQLEKKLQLMVEE----QDNLNKL-LENEQVQKLFVKTQLYGFLKEMGSEVSE 772
+E +L +LQL++EE +D L +L LEN +++K S
Sbjct: 2637 EELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKK------------------SL 2678
Query: 773 DSEEKDVV----NVLQAVGESLAKINE-EKCNLAFQRDEKVLELEKEIKCLQEESVVQCE 827
D KD V V + + E +++E EK + A D + E EI+ +E+ + E
Sbjct: 2679 DCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTN-KQYEVEIQTYREKLTSKEE 2737
Query: 828 ELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQ 887
L S + E LL+ EE+ + +A L E+K KT+++N ++ V+Q
Sbjct: 2738 CLSS----QKLEIDLLKSSKEELNNSLKATTQILEELK----KTKMDN------LKYVNQ 2783
Query: 888 TCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSV- 946
++E K K IK + K L E+KE+ + + K+ +V + + +
Sbjct: 2784 LKKENERAQGKMKLLIK---SCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELT 2840
Query: 947 KELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKD 1003
E++E E LE++ KE +E ++K + + +K L+ +++ +T L S +S++D
Sbjct: 2841 TEIKELKETLEEKTKEADEYLDKYCSLLISHEK-LEKAKEMLETQVAHLCSQQSKQD 2896
Score = 162 bits (410), Expect = 3e-39
Identities = 286/1403 (20%), Positives = 592/1403 (42%), Gaps = 157/1403 (11%)
Query: 196 EQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQ------ 249
++I L+ QLD EK++ QL + +EA Q ++ + + + E LK +Q
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDS-LEAALQKQKQKVENEKTEGTNLKRENQRLMEIC 76
Query: 250 EEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNA 309
E +++ +I + E+++N + KQ E E+ + K+ + ELE ++A +A
Sbjct: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQEL-KRCKSELERSQQAAQSA 135
Query: 310 NQDNQICS----ILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKL 365
+ C+ I T + K + L++ + + L+ EV L+
Sbjct: 136 DVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVK-----ALQA 190
Query: 366 EMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAG------LNKQFCYTV 419
+ +Q + + R+ + + + + ++ EK S L+ + + F +
Sbjct: 191 KKASQTLPQATMNHRDIARHQASSSVFSWQQ-----EKTPSHLSSNSQRTPIRRDFSASY 245
Query: 420 EQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILN 479
+EV + Q + N +F +S L + LK Q + L+ + E L
Sbjct: 246 FSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHL-----LDQLKAQNQELRNKINELELR 300
Query: 480 YESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNR 539
LQ E G+++ +F+ ++ Q EL +K + +D L+ T +
Sbjct: 301 ----------LQGHEKEMKGQVN-KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQ 349
Query: 540 LQGENEKLLSQQELVPELENTI---------------KNLQEKNGVYLLSLSQRDTMLKE 584
+ K + ++ + +L + + ++EK + LS++ +
Sbjct: 350 YDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQT 409
Query: 585 LEGKINSLTEEKDDFINKLKNSHE----EMDNFHKKCEREERLILELGKKVEQTIQYNSE 640
L+ + + + + KN H E+D ++ E + E +K+ + Q
Sbjct: 410 LDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQA 469
Query: 641 LEQKVNELTGGLEETLKE----KDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNK 696
+ K NEL +EE KE K ++QK ++ L K+ L+ + ++ EE
Sbjct: 470 SQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLN-QSQNFAEEMKA 528
Query: 697 LSSEKKQLSRDLEVFLSQKEDVI----LKEHITQLEKKLQLMVEEQDNLNKLLEN-EQVQ 751
++ ++ + RDL+ ++Q+E+ + LK + LEK+ QD L K + EQ+
Sbjct: 529 KNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC---SQDLLKKREHHIEQLN 585
Query: 752 KLFVKTQ-----LYGFLKEMGSEVSEDSEEKDVVNVLQAVGES-LAKINEEKCNLAFQRD 805
KT+ L L+ E E EEK + + ++ E L ++ EK NL
Sbjct: 586 DKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENL----Q 641
Query: 806 EKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLR-------KELEEIQSEKEALQ 858
K+ LE +K Q +S E +++L D E V +R + E++++K A
Sbjct: 642 SKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYM 701
Query: 859 SDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSE-----IHNE---KEKCF---IKEHE 907
+ + +++K + E +N+ ++ +++ E + NE K++C+ E+E
Sbjct: 702 ELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYE 761
Query: 908 NLKPLLEQKELRDRRAELILLKD------SLAKSPSVKNDPLSSVKELEEKIENLEKECK 961
+L+ LL+ K+ A L+ +D + + P++ + + + E + + + EC+
Sbjct: 762 SLRDLLKSKD-----ASLVTNEDHQRSLLAFDQQPAMHHSFANIIGE-QGSMPSERSECR 815
Query: 962 EKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKN 1021
+ ++ K + L+ S + + + +L+ E Q+ + + + AE
Sbjct: 816 LEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQ 875
Query: 1022 LLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSN 1081
+ + S+++ +E + ++ + + L N + + +N E A I+ L+ +
Sbjct: 876 SFV--AETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKS 933
Query: 1082 AKLLEVQILEVQ---RAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQL 1138
LLE + E+Q ++ KE+ + +++I+E L+E+ L +EK L
Sbjct: 934 NHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNL 993
Query: 1139 QKTMQELELVKKDAQQTTLMNMEIAD-YERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQ 1197
+Q+ E + E++D Y++ L Q+ N EDL Q+ K ++K
Sbjct: 994 ---IQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKN 1050
Query: 1198 ---ETLQEEITSL----QSSVQQYEEKNTKIKQLLVKTKKELADSK------QAETDHLI 1244
E L E TSL ++ ++Q +E K Q + TK A+ + + ET
Sbjct: 1051 SKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFL-TKLAFAEERNQNLMLELETVQQA 1109
Query: 1245 LQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQE 1304
L++ + S+ + K ++ + E++K+ + + +++++ + +V +
Sbjct: 1110 LRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLM-----KVMKTKH 1164
Query: 1305 ECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIK 1364
EC+ ++E S E R K Q + + + + + LE ++ ++K
Sbjct: 1165 ECQNLESEPIR-NSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELK 1223
Query: 1365 LQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSE 1424
LQ+S+ + ELQT++ + +T LQ+ S+E K C I +E +
Sbjct: 1224 LQESEKEKECLQHELQTIRGDLET------SNLQDMQSQEIS-GLKDCEIDAEEKYISGP 1276
Query: 1425 HTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSP 1484
H + SQ + N L+ S + + L E K E LQ + ++ +L ++E T +
Sbjct: 1277 HELSTSQ--NDNAHLQCSLQTTMNKL-NELEKICEILQAEKYELVTELNDSRSECITATR 1333
Query: 1485 VSSQQSLKNLRERR--NTDLPLL 1505
+++ K L E + N D LL
Sbjct: 1334 KMAEEVGKLLNEVKILNDDSGLL 1356
Score = 126 bits (317), Expect = 2e-28
Identities = 221/1184 (18%), Positives = 475/1184 (40%), Gaps = 169/1184 (14%)
Query: 582 LKELEGKINSLTEEK----------DDFINKLKNSHEEMDNFHKKCEREERLILELGKKV 631
++ELEG+++ L +EK + + K K E +RE + ++E+ + +
Sbjct: 20 IQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESL 79
Query: 632 EQTIQYNSE----LEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEV 687
E+T Q S E +VN G L K+ ++ +Q+L++ +++ + SA+V
Sbjct: 80 EKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELE--RSQQAAQSADV 137
Query: 688 K-----------------SLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKK 730
S Y +K K++ ++++E +++ + + Q +K
Sbjct: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE----ERKRLEAEVKALQAKKA 193
Query: 731 LQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQA----- 785
Q + + N + ++ +F Q ++ S +S +S+ + A
Sbjct: 194 SQTLPQATMNHRDIARHQASSSVFSWQQ-----EKTPSHLSSNSQRTPIRRDFSASYFSG 248
Query: 786 -----VGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840
S +I + N +F + L ++K +E + EL+ L+ +E+E
Sbjct: 249 EQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEM 308
Query: 841 VLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEK 900
+ +E+Q + E + +L+E + K R E Q ++ S + E
Sbjct: 309 KGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALE------- 361
Query: 901 CFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPL-SSVKELEEKIENLEKE 959
+ LK L E + + AE + SL + K + + + L++E
Sbjct: 362 ------QKLKKLTEDLSCQRQNAE--SARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQE 413
Query: 960 CKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESY 1019
C + + ++ + A L + + +VK++LE+ E Q Q ++
Sbjct: 414 CIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIK 473
Query: 1020 KNLLL----EYEKQSEQLDVEKER----ANNFEHRIEDLTRQLRNSTLQCETINSDNEDL 1071
+N L E +K++ L E+ + E ++++ + L S E + + N
Sbjct: 474 ENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQ 533
Query: 1072 LARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQL 1131
+ LQ E + + A+ D E + + Q K +EH +E+L +L
Sbjct: 534 ETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREH-----HIEQLNDKL 588
Query: 1132 QKEKKQLQKTMQELELVKKD----AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLE 1187
K +K+ + + LEL KK+ ++ TL + ++ E+L+ ++ + N +KI LE
Sbjct: 589 SKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLE 648
Query: 1188 QEIKIQKQK--------------QETLQEEITSLQSSV--QQYEEKNTKIKQLLVKTKKE 1231
+K Q+ K +E L EI +L + + + E + K+ + ++ K E
Sbjct: 649 TCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAE 708
Query: 1232 LADSK-QAETDHLILQAS-LKGELEASQQQVEVYKIQL-------AEITSEKHKIHEHLK 1282
+D K Q E +++ L+ S L G++E + ++++ ++ ++ +E + + LK
Sbjct: 709 FSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLK 768
Query: 1283 T------SAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKN 1336
+ + E HQR+L A+ Q+ A+ EQ ++ SE
Sbjct: 769 SKDASLVTNEDHQRSLLAFDQQ-PAMHHSFANIIGEQGSMPSE----------------- 810
Query: 1337 KSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKM 1396
+S + E + + + L+ +D L+ L+ + Q+N S+LQ K
Sbjct: 811 RSECRLEADQSPKNSAILQNRVDSLEFSLESQK---QMN-SDLQ--------------KQ 852
Query: 1397 LQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRK 1456
+E V + E+ E L + + +E +Q +S+L +N + + L+ + ++
Sbjct: 853 CEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKE 912
Query: 1457 ------TVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTV 1510
VET Q ++ +++ L++ +S SL+ L ++ +
Sbjct: 913 LQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEEL 972
Query: 1511 TREEG--EGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSST 1568
T+E G + + + + + ++S ++ E + + K L+Q+ T
Sbjct: 973 TQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEET 1032
Query: 1569 TKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIF 1628
+ + L+ + + N+ +++ L +E L N++ E + K
Sbjct: 1033 GNAYEDLSQKYKAAQEKNS----KLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTK 1088
Query: 1629 LKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRSSG 1672
L ER + N ML+L ++ + + + + S + G
Sbjct: 1089 LAFAEERNQ-----NLMLELETVQQALRSEMTDNQNNSKSEAGG 1127
Score = 125 bits (314), Expect = 3e-28
Identities = 181/790 (22%), Positives = 327/790 (41%), Gaps = 144/790 (18%)
Query: 19 KSKLETLPKEDLIKFAKKQMMLI--QKAKSRCTELEKEIEELR----------------- 59
K K+E L +E + ++++++ + +K+ L+ +IEE+
Sbjct: 2153 KDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEK 2212
Query: 60 ---SKPVTEGTGDI--IKALTERLDALLLEKAETEQQCLSLKKENIKMKQ----EVEDSV 110
+K + E G + + L +LL EK + E Q K ++M Q E+ ++V
Sbjct: 2213 ENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAV 2272
Query: 111 TKM-GDAH--KELEQSHINYVKEIENLKNELMAVRS----------------KYSEDKAN 151
+ GD K EQS ++E L+N + +R+ K SE A+
Sbjct: 2273 AALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHAD 2332
Query: 152 LQKQLEEAMNTQLELSEQLKFQ-----NNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
L K E + +LE++ + NS+ V+ L+ +IE G + + L+ +
Sbjct: 2333 LLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIE----GMTQSLRGLELDVV 2388
Query: 207 ATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEH 266
EK+ +LQ E S+ + INS E +LQ K + ++KE +
Sbjct: 2389 TIRSEKENLTNELQKEQERISE--LEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQ 2446
Query: 267 EAEINKLNELKENLVKQCEASEKNIQKKYEC-ELENLRKATSNANQDNQICSILLQENTF 325
E+N+ N + C+A E+N+ + EC ELE + N + N
Sbjct: 2447 LKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGL 2506
Query: 326 VEQVVNEKVK-------------------HLEDTLKELESQHSILKDEVTYMNNLKLKLE 366
+++V + K K L L ++E +H + K++ + NL ++LE
Sbjct: 2507 IQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELE 2566
Query: 367 MDAQHIKDEFFHEREDLEFKI-------NELLLAKEEQGCVIEKLKSELAGLNKQFCYTV 419
Q ++ + ++ LE NEL L K ++ +EK+ A
Sbjct: 2567 QKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTA---------- 2616
Query: 420 EQHNREVQSLKEQHQ--KEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAI 477
+E + +E H+ ++ +EL E + EK L E+Q L E+ ++ + + +E
Sbjct: 2617 ----KETELQREMHEMAQKTAELQE----ELSGEKNRLAGELQLLLEEIKSSKDQLKELT 2668
Query: 478 LNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETV 537
L L++ ++ + + E GK+ +E + E Q +L A + ALL
Sbjct: 2669 LENSELKKSLDCMHKDQVEKEGKVREE-----------IAEYQLRLHEAEKKHQALLLDT 2717
Query: 538 NR-----LQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEG-KINS 591
N+ +Q EKL S++E + + I L+ SL +L+EL+ K+++
Sbjct: 2718 NKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDN 2777
Query: 592 LTEEKDDFINKLKNSHE----EMDNFHKKCER--EERLILELGKKVEQTIQYNS------ 639
L ++N+LK +E +M K C++ EE+ IL+ Q Q
Sbjct: 2778 LK-----YVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVM 2832
Query: 640 -----ELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEEN 694
EL ++ EL LEE KE D+ K L++ + L + KE+L +V L +
Sbjct: 2833 DTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQ 2892
Query: 695 NKLSSEKKQL 704
+K S L
Sbjct: 2893 SKQDSRGSPL 2902
Score = 116 bits (290), Expect = 2e-25
Identities = 223/1070 (20%), Positives = 431/1070 (40%), Gaps = 150/1070 (14%)
Query: 643 QKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKK 702
QK+ EL G L++ KEK Q +L+ L ++ + E E +L EN +L
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRL----- 72
Query: 703 QLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGF 762
+E+ S ++ H Q+++ E Q N K +Q++KL +
Sbjct: 73 -----MEICESLEKTKQKISHELQVKESQVNFQEGQLNSGK----KQIEKLEQE------ 117
Query: 763 LKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEES 822
LK SE+ + A ++ CN +K+ + Q S
Sbjct: 118 LKRCKSELERSQQ-----------AAQSADVSLNPCNTP----QKIFTTP--LTPSQYYS 160
Query: 823 VVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQV 882
+ E+LK +E+ L E++ +Q++K + M + + + ++
Sbjct: 161 GSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQ 220
Query: 883 EE-----VSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDS----LA 933
+E +S ++ I + + + + P ++ R A +S L
Sbjct: 221 QEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL 280
Query: 934 KSPSVKNDPL-SSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVK 992
+N L + + ELE +++ EKE K + K +++L KAK EL K +
Sbjct: 281 DQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCR 340
Query: 993 EELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTR 1052
+EL ++ DQ S Y L + +K +E L +++ A + +E +
Sbjct: 341 DELVRTTAQYDQAST----------KYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIK 390
Query: 1053 QLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAM-------VDKELEA 1105
+ + Q E E +Q A+L + E+Q+AK M +DK L +
Sbjct: 391 E-KEKEFQEELSRQQRSFQTLDQECIQMKARLTQ----ELQQAKNMHNVLQAELDK-LTS 444
Query: 1106 EKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELE----LVKKDAQQTTLMNME 1161
K Q E ++E + E+ Q ++ +L+++M+E++ L+K ++Q E
Sbjct: 445 VKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKA---RE 501
Query: 1162 IADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKI 1221
+ E +K + Q L N+ ++ +E+K + QET+ + LQ + Q E T
Sbjct: 502 VCHLEAELKNIKQCL----NQSQNFAEEMKAKNTSQETM---LRDLQEKINQQENSLT-- 552
Query: 1222 KQLLVKTKKELAD-SKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEH 1280
L K K +AD KQ + + L+ + +E QL + S+ K +
Sbjct: 553 ---LEKLKLAVADLEKQRDCSQDL--------LKKREHHIE----QLNDKLSKTEKESKA 597
Query: 1281 LKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMS 1340
L ++ E ++ ++ T K+E + ++ ES K + + + + +
Sbjct: 598 LLSALELKKKEYEELKEEKTLFS----CWKSENEKLLTQMESEKENLQSKINHLETCLKT 653
Query: 1341 QAETEGAKQER-EHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQE 1399
Q ER LEM + L +++++ N L E++T K+
Sbjct: 654 QQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVET------------QKLAYM 701
Query: 1400 TVSKEAELREKLCSIQSENMMMK-SEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTV 1458
+ ++AE ++ + ENM +K S+ T V L + ++L N D+ R Q+ H +
Sbjct: 702 ELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAE-Y 760
Query: 1459 ETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGM 1518
E+L+ L +A L + NE RS ++ Q N + + ++ E E
Sbjct: 761 ESLRDLLKSKDASL--VTNEDHQRSLLAFDQQPAMHHSFANI---IGEQGSMPSERSECR 815
Query: 1519 ETTDTESVSSA--STYTQSLEQLLNSPE---TKLEPPLWHAEFTKEELVQKL-------- 1565
D +SA SLE L S + + L+ K E+ + L
Sbjct: 816 LEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQ 875
Query: 1566 SSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLE-RNQEREKSAANLEYLK--NV 1622
S +++ ++ L +T A ++ E + L+++ + L+ N + E A ++ LK N
Sbjct: 876 SFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNH 935
Query: 1623 LLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRSSG 1672
LL+ + + L +++ L L +E + ++ + E E ++ +G
Sbjct: 936 LLE--------DSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENG 977
Score = 110 bits (274), Expect = 2e-23
Identities = 161/736 (21%), Positives = 301/736 (40%), Gaps = 121/736 (16%)
Query: 943 LSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSS-------RKETQTVKEEL 995
L ++ELE +++ L+KE ++++ +++ ++ K K+++++ ++E Q + E
Sbjct: 17 LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEIC 76
Query: 996 ESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLR 1055
ESL K ++S ++ + L +KQ E+L+ E +R + R + +
Sbjct: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
Query: 1056 NSTLQCET---------------INSDNEDLLARIETLQSNAKLLEVQILEVQRAKA--- 1097
S C T S EDL + K LE ++ +Q KA
Sbjct: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQT 196
Query: 1098 -----MVDKELEAEKLQ------KEQKIKEHATTVNELEELQVQLQKE----KKQLQKTM 1142
M +++ + +++K H ++ ++ ++ ++++ +
Sbjct: 197 LPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSR 256
Query: 1143 QELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIE----DLEQEIKIQKQKQE 1198
L++ K+DA + N +K NQ+L NK N++E E+E+K Q K +
Sbjct: 257 STLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQ 316
Query: 1199 TLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLK---GELEA 1255
LQ ++ + + + E+ K + LV+T A QA T + L+ LK +L
Sbjct: 317 ELQLQLEKAKVELIEKEKVLNKCRDELVRT---TAQYDQASTKYTALEQKLKKLTEDLSC 373
Query: 1256 SQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQAT 1315
+Q E + L + EK K + Q LS Q+ L +EC KA
Sbjct: 374 QRQNAESARCSLEQKIKEKEK----------EFQEELSRQQRSFQTLDQECIQMKAR--- 420
Query: 1316 VTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKL---QDSQNNL 1372
+T E + K +HNVL QAE + ++ LE +++ K KL + +
Sbjct: 421 LTQELQQAK-NMHNVL---------QAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQAS 470
Query: 1373 QINVSEL----QTLQSEHDTLLERHNKMLQETVSKEAELRE-KLCSIQSENMMMKSEHTQ 1427
QI +EL + ++ E++ L + +E EAEL+ K C QS+N + +
Sbjct: 471 QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMK--- 527
Query: 1428 TVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSS 1487
++ TSQ +LR+ Q + Q+E+ T+E L+ ++ +E Q
Sbjct: 528 --AKNTSQETMLRDL---QEKINQQENSLTLEKLKLAVADLEKQR-------------DC 569
Query: 1488 QQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKL 1547
Q L RE L + + T+ ES + S ++ E K
Sbjct: 570 SQDLLKKREHHIEQL------------NDKLSKTEKESKALLSALELKKKEYEELKEEKT 617
Query: 1548 EPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQ 1607
W +E E+L+ ++ S ++L + E + +QIK + R
Sbjct: 618 LFSCWKSE--NEKLLTQMES---EKENLQSKINHLE--TCLKTQQIKSHEYNERVRTLEM 670
Query: 1608 EREKSAANLEYLKNVL 1623
+RE + + L NVL
Sbjct: 671 DRENLSVEIRNLHNVL 686
Score = 55.1 bits (131), Expect = 6e-07
Identities = 97/485 (20%), Positives = 186/485 (38%), Gaps = 58/485 (11%)
Query: 1177 TNKNNKIEDLEQEI-KIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADS 1235
T KI++LE ++ K++K+KQ+ Q ++ SL++++Q+ ++K K K+E
Sbjct: 14 TRALQKIQELEGQLDKLKKEKQQR-QFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRL 72
Query: 1236 KQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAY 1295
+ + + EL+ + QV + QL + K+ + LK + +R+ A
Sbjct: 73 MEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAA 132
Query: 1296 QQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQ---AETEGAKQERE 1352
Q +L C + T + + Y + LK++ NK + + E E + +
Sbjct: 133 QSADVSL-NPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAK 191
Query: 1353 HLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNK-------MLQETVSKEA 1405
+ Q + +D + Q + S Q + + L +++ S E
Sbjct: 192 KASQTLPQATMNHRDIARH-QASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQ 250
Query: 1406 ELREKLCSIQ------SENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRK--- 1456
E+ ++Q + + S + QL +QN+ LRN + LQ ++
Sbjct: 251 EVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKG 310
Query: 1457 ---TVETLQQQLSKMEAQLFQLKN----------------EPTTRSPVSSQQSLKNLRE- 1496
+ LQ QL K + +L + + + + + +Q LK L E
Sbjct: 311 QVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTED 370
Query: 1497 ----RRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLW 1552
R+N + + +E+ E E +S Q+L+Q + +L L
Sbjct: 371 LSCQRQNAESARCSLEQKIKEK----EKEFQEELSRQQRSFQTLDQECIQMKARLTQELQ 426
Query: 1553 HAEFTKEELVQKLSSTTKSADHLNGLLRE-----TEATNAILMEQIKLLKSEIRRLERNQ 1607
A+ L +L T L L E A A QIK ++E+RR
Sbjct: 427 QAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIK--ENELRRSMEEM 484
Query: 1608 EREKS 1612
++E +
Sbjct: 485 KKENN 489
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 194 bits (493), Expect = 6e-49
Identities = 298/1343 (22%), Positives = 578/1343 (43%), Gaps = 191/1343 (14%)
Query: 403 KLKSELAGLNKQFCYTVEQHNRE--VQSLKEQHQKEISEL------------NETFLSDS 448
KL+S+ ++ HN V+ +K +Q+ + +L F
Sbjct: 58 KLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQG 117
Query: 449 EKEKLTLMFEIQGLKEQCENLQQEKQEAI-----LNYESLREIMEILQTELGESAGKISQ 503
+E L+ + G QC Q+K+E I L++++ + +Q
Sbjct: 118 TEEVKKLLLLLLGCAVQC----QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDL 173
Query: 504 EFESMKQQQASDVHELQQK----LRTAFTEKDALLETVNRLQGENEKLLSQQELVPELEN 559
++ + D+ L + L+ E+D ET+ L E + L +P +
Sbjct: 174 QWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGL----HFLPHASS 229
Query: 560 TIKNLQEKNGVYLLSLSQRDTM-LKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCE 618
+ ++ G+ Q ++ L + + KI L +E ++ +L + +E++ + +
Sbjct: 230 SAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELK 289
Query: 619 REERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSE 678
R ++ + L Y EL+ L+EK KLE + + K
Sbjct: 290 RLQQENMNLLSDARSARMYRDELD------------ALREKAVRVDKLESEVSRYKERLH 337
Query: 679 DKEVLSAEVKSLYEENNKLSSEKKQLSRDLE--------VFLSQKEDVILKEHITQLE-- 728
D E A V+ L E+N L K L LE + +KE++ LK + +E
Sbjct: 338 DIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEME 397
Query: 729 -----KKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMG--SEVSEDSEEKDVVN 781
KK++ ++EE N LE Q Q + L L+++ SE+SE ++
Sbjct: 398 RDMDRKKIEELMEE----NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHE 453
Query: 782 VLQAVGESLAKINEEKCNLAFQRDE-------------KVLELEKE-------IKCLQEE 821
V + L K+ E +L +E K+L++EKE ++ L+ E
Sbjct: 454 VNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENE 513
Query: 822 SVVQCEELKS---LLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNAN---------E 869
V + + L++ L +D +EK L K +E ++ E Q +LE +N + +
Sbjct: 514 IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER-QIKILEQENEHLNQTVSSLRQ 572
Query: 870 KTRLENQNLLIQVEEVSQTCSKS--EIHNEKEKCFIKEHENLKPLLEQKELRDRRAELIL 927
++++ + + +E+ ++ +S E ++ K ++ + K L KE +R EL
Sbjct: 573 RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN 632
Query: 928 LKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
L K + ++++K EKIE LE+E E E + K+K K LDS +
Sbjct: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK-------KTLDSFKNL 685
Query: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNL---LLEYEKQSEQLDVEKERANNFE 1044
T +LESL E QL +L + ES K + + + ++++L+ EKE+
Sbjct: 686 TF----QLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
Query: 1045 HRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELE 1104
++ ++ + + ++ +N+ L +E + LE ++ +++ + K LE
Sbjct: 742 ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801
Query: 1105 AEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLM--NMEI 1162
K+ + ++++ LE+ QL+K+KKQL+K + L + + + TTL N++I
Sbjct: 802 ELKISSK-RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ-QAEIKDTTLEENNVKI 859
Query: 1163 ADYERLMKELNQKLTNKNN---KIEDLEQEIK-------IQKQKQETLQEEITSLQSSVQ 1212
+ E+ K L++++ ++++LE+E K I + TL+E++ S + Q
Sbjct: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQ 919
Query: 1213 QYEEKNTKIKQLLVK---TKKELADSKQAETDHLIL-----QASLKGELEASQQQVEVYK 1264
Q K+ L K K+ L +Q+ D L +++LK LE ++++ +
Sbjct: 920 QMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALE 979
Query: 1265 IQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAA----KAEQATVTSEF 1320
+L E T+ ++ + LKT + ++ L Q +Q + K E+ + +
Sbjct: 980 ARLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGEDNKWERESQETTR 1038
Query: 1321 ESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLE----------MLIDQLKIKLQDSQN 1370
E KV+ +++ ++N + QAE + K + + LE + + + + LQ+
Sbjct: 1039 ELLKVK-DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNT 1097
Query: 1371 NLQINVSELQ----TLQSEHDTLLERHNKML---------QETVSKEAE-LREKLCSIQS 1416
LQ ++LQ TL S+ +L+ ++ ++L E+V KE E L+ S+
Sbjct: 1098 TLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIK 1157
Query: 1417 ENMMMKSEHTQTVSQ---LTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLF 1473
++ ++ H + S+ L S++ L+++ ++ L+ EHR +E QL K + QL
Sbjct: 1158 DHEKLELLHERQASEYESLISKHGTLKSAHKN----LEVEHRD-LEDRYNQLLKQKGQLE 1212
Query: 1474 QLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDT--ESVSSAST 1531
L+ + + K L E +N + + + E T + T
Sbjct: 1213 DLEK-------MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT 1265
Query: 1532 YTQSLEQLLNSPETKLEPPLWHAEFTK-EELVQKLSSTTKSADH----LNGLLRETEATN 1586
++L+ LLN+ +KLE AEF+K +E Q+L T+ ++ L+ L E N
Sbjct: 1266 DHKNLKSLLNN--SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN 1323
Query: 1587 AILMEQIKLLKSEIRR-LERNQE 1608
L++QI+ L + R LE+N E
Sbjct: 1324 RHLLDQIQTLMLQNRTLLEQNME 1346
Score = 178 bits (452), Expect = 3e-44
Identities = 270/1222 (22%), Positives = 541/1222 (44%), Gaps = 196/1222 (16%)
Query: 422 HNREVQSLKEQHQKEISELNET-----FLSDSEKEKLTLMFEIQGLK--EQCENLQQEKQ 474
H + + +++H + I EL+E FL + + G+K E ++L E
Sbjct: 196 HLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGS-PGMKRTESRQHLSVELA 254
Query: 475 EAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ--QKLRTAFTEKDA 532
+A LR+ +E +L + ++ Q +K+ Q +++ L + R E DA
Sbjct: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA 314
Query: 533 LLETVNRLQGENEKLLSQQELVPELE---NTIKNLQEKNGVYLLSLSQRDTMLKE-LEG- 587
L E R+ ++ +E + ++E ++ L+E N V L + TML++ LEG
Sbjct: 315 LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL----ETKTMLEDQLEGT 370
Query: 588 -----KINSLTEEKDDFINKLKNSHEEMDNFHKKCER--EERLILELGKK--VEQTIQYN 638
K++ L +E KL + E D KK E EE + LE+ +K +++++
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430
Query: 639 SELEQ-----------------KVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKE 681
ELEQ +VNELT L + + +Q L K + +++ + E
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSS---RLLKLEMENQSLTKTVEELRTTVDSVE 487
Query: 682 VLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDV---------ILKEHITQLEKKLQ 732
++++ + +EN +LS + + L ++ + +K+ + ++KE QLEK ++
Sbjct: 488 GNASKILKMEKENQRLSKKVEILENEI---VQEKQSLQNCQNLSKDLMKEK-AQLEKTIE 543
Query: 733 LMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAK 792
+ E + K+LE E Q L++ S++S ++ KD+ + + ES+ +
Sbjct: 544 TLRENSERQIKILEQENEHL----NQTVSSLRQR-SQISAEARVKDIEKENKILHESIKE 598
Query: 793 INEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE--EI 850
+ + + F++ + ELE +E + EEL++ L E+E LL+K++ +I
Sbjct: 599 TSSKLSKIEFEKRQIKKELEH-----YKEKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 851 QSEK-EALQSDLLEMKNANEKTR--LEN-QNLLIQVEEVSQTCSKSEIHN-------EKE 899
EK EAL+ + E++ N K + L++ +NL Q+E + + S+ + N E
Sbjct: 654 TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 900 KCFIKEHENLKPLLEQKELRDRRAELI----LLKDSLAKSP---------SVKNDPLSS- 945
KC + L+ LE KEL + +L LLK S K+ ++N L
Sbjct: 714 KCASMKMAQLQ--LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 946 -------VKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESL 998
+++LE ++++LE E + ++ + ++K+ + K L+ KE +++++E L
Sbjct: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEELKI----SSKRLEQLEKENKSLEQETSQL 827
Query: 999 RSEKDQLSASMRDLIQGAE-----------SYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
+K QL + L Q AE NL E + S+++ + KE +
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
Query: 1048 EDLTRQLRNSTLQCETINSDNEDLLA-RIETLQSNAKLL----EVQILEVQRAKAMVDKE 1102
++ ++ +T+ +T+ + EDL++ +++T Q N L E++ + + + + + D++
Sbjct: 888 KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947
Query: 1103 LEAEKLQK-EQKIKEHATTVNELEE-----LQVQLQKEKKQLQKTMQELELVKKD----- 1151
++ + E K++ E++E L+ +L++ Q+ QEL+ VKK+
Sbjct: 948 STDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALK 1007
Query: 1152 --------AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLE----------QEIKIQ 1193
Q + ++ E +ER +E ++L +++ ++E Q +K Q
Sbjct: 1008 QRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1067
Query: 1194 KQKQET----LQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASL 1249
++ ET LQ +I +LQ +E+NT ++ K + E + T + A L
Sbjct: 1068 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127
Query: 1250 ---KGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEEC 1306
+ LE + V + L + K HE L+ H+R S Y+ ++
Sbjct: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELL---HERQASEYESLIS------ 1178
Query: 1307 RAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQ 1366
+ T+ S ++ +V H L+ + N+ + Q K + E LE ++ + K+
Sbjct: 1179 -----KHGTLKSAHKNLEVE-HRDLEDRYNQLLKQ------KGQLEDLEKMLKVEQEKML 1226
Query: 1367 DSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAE---LREKLCSIQSENMMMKS 1423
N + +E + L E+D L ++++L+ET + + L+ L + + E +++
Sbjct: 1227 LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA 1286
Query: 1424 EHTQTVSQLTSQNEVLRNSFRDQVR-------HLQEEHRKTVETLQQQLSKMEAQLFQLK 1476
E ++ Q Q ++ +Q +L+EE+R ++ + Q L L +
Sbjct: 1287 EFSKLKEQY-QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQI-QTLMLQNRTLLEQN 1344
Query: 1477 NEPTTRSPVSSQQSLKNLRERR 1498
E V +Q + L E R
Sbjct: 1345 MESKDLFHVEQRQYIDKLNELR 1366
Score = 169 bits (429), Expect = 2e-41
Identities = 259/1213 (21%), Positives = 526/1213 (43%), Gaps = 185/1213 (15%)
Query: 529 EKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDT--MLKELE 586
+K+ +E + L + + ++ + E+ + +N+ + + + +SQ D +LK +
Sbjct: 137 KKEEFIERIQGLDFDTKAAVAAH--IQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMA 194
Query: 587 GKINSLTEEKDDFINKLKNSHEEMDNFH------------------KKCEREERLILELG 628
+ L +E+D+ + EE D H K+ E + L +EL
Sbjct: 195 LHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELA 254
Query: 629 KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQ-MKVLSEDKE--VLSA 685
+ + ELE+K +L + +E +Q + +L++L + M +LS+ + +
Sbjct: 255 DAKAKIRRLRQELEEKTEQLL----DCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310
Query: 686 EVKSLYEENNKLSSEKKQLSR------DLEVFLSQKEDV-----ILKEHITQLEKKLQLM 734
E+ +L E+ ++ + ++SR D+E + ++ E++ +L E T LE +L+
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 370
Query: 735 VEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKIN 794
D L++L E E +Q +K +L+ E+ D + K +
Sbjct: 371 RARSDKLHEL-EKENLQ---LKAKLHDM------EMERDMDRKKI--------------- 405
Query: 795 EEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEK 854
E+++E ++ Q++S+ + SL +E E++ EL E + +
Sbjct: 406 -----------EELMEENMTLEMAQKQSMDE-----SLHLGWELEQISRTSELSE--APQ 447
Query: 855 EALQSDLLEMKNANE-KTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913
++L ++ E+ ++ K +ENQ+L VEE+ T E + K KE++ L +
Sbjct: 448 KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV 507
Query: 914 EQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLE-------KECKEKEEK 966
E E E++ K SL ++ D + +LE+ IE L K +++ E
Sbjct: 508 EILE-----NEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEH 562
Query: 967 INKI-----KLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKN 1021
+N+ + + A+ + KE + + E ++ S+ ++ R + + E YK
Sbjct: 563 LNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK- 621
Query: 1022 LLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI------NSDNEDLLARI 1075
E +++E+L+ E ++ E E L +++ N + CE I NS+ E ++
Sbjct: 622 ---EKGERAEELENE---LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
Query: 1076 ETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEK 1135
+ + K L Q+ +++ + +D+E E + + +K + + +L+ +L+ EK
Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLENKELESEK 734
Query: 1136 KQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQ 1195
+QL+K LEL+K ++T + + + + L + L N N KI+ LE E++ +
Sbjct: 735 EQLKKG---LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
Query: 1196 KQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDH--LILQASLK--- 1250
+ +TLQ+ + L+ S ++ E+ + K L +T + D KQ E ++ L QA +K
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 1251 --------GELEAS----QQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQR 1298
G LE +++ +YK + E K ++ L A +TL ++
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRL-KELEKENKELVKRATIDIKTLVTLRED 910
Query: 1299 VTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKN-----KSMSQAETEGAKQEREH 1353
+ + + + + + +T E E + +L +++ K + K+ E
Sbjct: 911 LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEI 970
Query: 1354 LEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHN------------------- 1394
E I L+ +L++S N Q EL+T++ ++ L +R +
Sbjct: 971 KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE 1030
Query: 1395 KMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEH 1454
+ QET + +++++L ++ N +++E +QL Q E N+ + Q+ LQ
Sbjct: 1031 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL-KQLETQNNNLQAQILALQ--- 1086
Query: 1455 RKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREE 1514
R+TV +LQ+Q + ++ Q +L+ E +T + S SL N +N L L+ ++ E
Sbjct: 1087 RQTV-SLQEQNTTLQTQNAKLQVENSTLN--SQSTSLMN----QNAQL-LIQQSSLENE- 1137
Query: 1515 GEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADH 1574
ESV +SL L KLE E L+ K + + +
Sbjct: 1138 --------NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN 1189
Query: 1575 LNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSE 1634
L R+ E L++Q K ++ LE+ + E+ LE + + + K E
Sbjct: 1190 LEVEHRDLEDRYNQLLKQ----KGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGE 1245
Query: 1635 RERLLPVINTMLQ 1647
+RL + +L+
Sbjct: 1246 NDRLNHTYSQLLK 1258
Score = 167 bits (423), Expect = 8e-41
Identities = 274/1183 (23%), Positives = 510/1183 (43%), Gaps = 167/1183 (14%)
Query: 19 KSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPV-TEGTGDIIKALTER 77
K +LE + E L + ++ M L+ A+S E++ LR K V + + ER
Sbjct: 278 KQELEQMEIE-LKRLQQENMNLLSDARS-ARMYRDELDALREKAVRVDKLESEVSRYKER 335
Query: 78 LDALLLEKAETEQQCLSLKKEN---IKMKQEVEDSVT---KMGDAHKELEQSHINYVKEI 131
L + KA E+ LK++N ++ K +ED + D ELE+ ++ ++
Sbjct: 336 LHDIEFYKARVEE----LKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKL 391
Query: 132 ENLKNELMAVRSKYSE---DKANLQKQLEEAMNTQLELSEQL----KFQNNSEDNVKKLQ 184
+++ E R K E + L+ +++M+ L L +L + SE K L
Sbjct: 392 HDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG 451
Query: 185 EEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNI------IEANSQHYQKNINSLQ 238
E+ ++ ++ + L T +E + TV ++ +E +Q K + L+
Sbjct: 452 HEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 511
Query: 239 EELLQLKAIHQEEVKELMCQ-IEASAKEHEAEINKLNE-LKENLVKQCEASEKNIQKKYE 296
E++Q K Q CQ + + +A++ K E L+EN SE+ I K E
Sbjct: 512 NEIVQEKQSLQN------CQNLSKDLMKEKAQLEKTIETLREN-------SERQI-KILE 557
Query: 297 CELENLRKATSNANQDNQICSILLQENTFVE-QVVNEKVKHLEDTLKELESQHSILKDEV 355
E E+L + S+ Q +QI + ++ E ++++E +K L ++E + +K E
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE- 616
Query: 356 TYMNNLKLKLEMDAQHIKDEFFH---EREDLEFKINELLLAKEEQGCVIEKLKSELAGLN 412
+ + K K E A+ +++E H E E L+ KI L + E+ +E+ SEL N
Sbjct: 617 --LEHYKEKGER-AEELENELHHLEKENELLQKKITNLKITCEKIEA-LEQENSELEREN 672
Query: 413 KQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLK---EQCENL 469
++ T++ L E +KE S+L+E E L L ++ LK + L
Sbjct: 673 RKLKKTLDSFKNLTFQL-ESLEKENSQLDE--------ENLELRRNVESLKCASMKMAQL 723
Query: 470 QQEKQEAILNYESLREIMEILQTEL----------------GESAGKISQEFESMKQQQA 513
Q E +E E L++ +E+L+ + K + QQ
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 514 SDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLL 573
S++ +L+ + +T + L + RL+ ++ S ++ +LE K L+++N
Sbjct: 784 SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ 843
Query: 574 SLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQ 633
+DT L+E KI +L +E K +E+ + + C R + L E + V++
Sbjct: 844 QAEIKDTTLEENNVKIGNLEKEN-------KTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 634 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEE 693
+++ V + E LK + N+ LEKL +++ + +KE L + +S +
Sbjct: 897 A---TIDIKTLVTLREDLVSEKLKTQQMNND-LEKLTHELEKIGLNKERLLHDEQSTDDR 952
Query: 694 NNKLSSE-KKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQK 752
L S+ + L + LE I +E I LE +L EE N N+ L Q+
Sbjct: 953 YKLLESKLESTLKKSLE---------IKEEKIAALEARL----EESTNYNQQLR----QE 995
Query: 753 LFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGE--SLAKINEEKCNLAFQRDEKVLE 810
L + Y LK+ EE+ V + GE + ++E + ++++E
Sbjct: 996 LKTVKKNYEALKQ------RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1049
Query: 811 LEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEK 870
+E+ LQ E + LK+ L+ E + L+ ++ +Q + +LQ ++ N K
Sbjct: 1050 VERNNATLQAEK----QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK 1105
Query: 871 TRLEN-----QNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAEL 925
++EN Q+ + + +S + NE E IKE E+LK L + + EL
Sbjct: 1106 LQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES-VIKEREDLKSLYDSLIKDHEKLEL 1164
Query: 926 ILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKI-----------KLVA 974
+ + S +S L+ +NLE E ++ E++ N++ K++
Sbjct: 1165 L-----HERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1219
Query: 975 VKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAE-------SYKNLLLEYE 1027
V+ +K L K +TV E + L E D+L+ + L++ E + K+LL +
Sbjct: 1220 VEQEKML-LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSK 1278
Query: 1028 KQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCE-------TINSDNEDLLARIETLQS 1080
+ +L+ E + +++ + +L N QCE + +N LL +I+TL
Sbjct: 1279 LEQTRLEAEFSKLKEQYQQLDITSTKLNN---QCELLSQLKGNLEEENRHLLDQIQTLML 1335
Query: 1081 NAKLLEVQILEVQ-----RAKAMVDK--ELEAEKLQKEQKIKE 1116
+ L Q +E + + +DK EL +K + E+KI +
Sbjct: 1336 QNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1378
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 194 bits (492), Expect = 8e-49
Identities = 298/1344 (22%), Positives = 578/1344 (43%), Gaps = 192/1344 (14%)
Query: 403 KLKSELAGLNKQFCYTVEQHNRE--VQSLKEQHQKEISEL------------NETFLSDS 448
KL+S+ ++ HN V+ +K +Q+ + +L F
Sbjct: 58 KLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQG 117
Query: 449 EKEKLTLMFEIQGLKEQCENLQQEKQEAI-----LNYESLREIMEILQTELGESAGKISQ 503
+E L+ + G QC Q+K+E I L++++ + +Q
Sbjct: 118 TEEVKKLLLLLLGCAVQC----QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDL 173
Query: 504 EFESMKQQQASDVHELQQK----LRTAFTEKDALLETVNRLQGENEKLLSQQELVPELEN 559
++ + D+ L + L+ E+D ET+ L E + L +P +
Sbjct: 174 QWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGL----HFLPHASS 229
Query: 560 TIKNLQEKNGVYLLSLSQRDTM-LKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCE 618
+ ++ G+ Q ++ L + + KI L +E ++ +L + +E++ + +
Sbjct: 230 SAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELK 289
Query: 619 REERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSE 678
R ++ + L Y EL+ L+EK KLE + + K
Sbjct: 290 RLQQENMNLLSDARSARMYRDELD------------ALREKAVRVDKLESEVSRYKERLH 337
Query: 679 DKEVLSAEVKSLYEENNKLSSEKKQLSRDLE--------VFLSQKEDVILKEHITQLE-- 728
D E A V+ L E+N L K L LE + +KE++ LK + +E
Sbjct: 338 DIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEME 397
Query: 729 -----KKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMG--SEVSEDSEEKDVVN 781
KK++ ++EE N LE Q Q + L L+++ SE+SE ++
Sbjct: 398 RDMDRKKIEELMEE----NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHE 453
Query: 782 VLQAVGESLAKINEEKCNLAFQRDE-------------KVLELEKE-------IKCLQEE 821
V + L K+ E +L +E K+L++EKE ++ L+ E
Sbjct: 454 VNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENE 513
Query: 822 SVVQCEELKS---LLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNAN---------E 869
V + + L++ L +D +EK L K +E ++ E Q +LE +N + +
Sbjct: 514 IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER-QIKILEQENEHLNQTVSSLRQ 572
Query: 870 KTRLENQNLLIQVEEVSQTCSKS--EIHNEKEKCFIKEHENLKPLLEQKELRDRRAELIL 927
++++ + + +E+ ++ +S E ++ K ++ + K L KE +R EL
Sbjct: 573 RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN 632
Query: 928 LKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
L K + ++++K EKIE LE+E E E + K+K K LDS +
Sbjct: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK-------KTLDSFKNL 685
Query: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNL---LLEYEKQSEQLDVEKERANNFE 1044
T +LESL E QL +L + ES K + + + ++++L+ EKE+
Sbjct: 686 TF----QLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
Query: 1045 HRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELE 1104
++ ++ + + ++ +N+ L +E + LE ++ +++ + K LE
Sbjct: 742 ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801
Query: 1105 AEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLM--NMEI 1162
K+ + ++++ LE+ QL+K+KKQL+K + L + + + TTL N++I
Sbjct: 802 ELKISSK-RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ-QAEIKDTTLEENNVKI 859
Query: 1163 ADYERLMKELNQKLTNKNN---KIEDLEQEIK-------IQKQKQETLQEEITSLQSSVQ 1212
+ E+ K L++++ ++++LE+E K I + TL+E++ S + Q
Sbjct: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQ 919
Query: 1213 QYEEKNTKIKQLLVK---TKKELADSKQAETDHLI------LQASLKGELEASQQQVEVY 1263
Q K+ L K K+ L +Q+ D L+++LK LE ++++
Sbjct: 920 QMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAAL 979
Query: 1264 KIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAA----KAEQATVTSE 1319
+ +L E T+ ++ + LKT + ++ L Q +Q + K E+ + +
Sbjct: 980 EARLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGEDNKWERESQETT 1038
Query: 1320 FESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLE----------MLIDQLKIKLQDSQ 1369
E KV+ +++ ++N + QAE + K + + LE + + + + LQ+
Sbjct: 1039 RELLKVK-DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1097
Query: 1370 NNLQINVSELQ----TLQSEHDTLLERHNKML---------QETVSKEAE-LREKLCSIQ 1415
LQ ++LQ TL S+ +L+ ++ ++L E+V KE E L+ S+
Sbjct: 1098 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLI 1157
Query: 1416 SENMMMKSEHTQTVSQ---LTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQL 1472
++ ++ H + S+ L S++ L+++ ++ L+ EHR +E QL K + QL
Sbjct: 1158 KDHEKLELLHERQASEYESLISKHGTLKSAHKN----LEVEHRD-LEDRYNQLLKQKGQL 1212
Query: 1473 FQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDT--ESVSSAS 1530
L+ + + K L E +N + + + E T +
Sbjct: 1213 EDLEK-------MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ 1265
Query: 1531 TYTQSLEQLLNSPETKLEPPLWHAEFTK-EELVQKLSSTTKSADH----LNGLLRETEAT 1585
T ++L+ LLN+ +KLE AEF+K +E Q+L T+ ++ L+ L E
Sbjct: 1266 TDHKNLKSLLNN--SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEE 1323
Query: 1586 NAILMEQIKLLKSEIRR-LERNQE 1608
N L++QI+ L + R LE+N E
Sbjct: 1324 NRHLLDQIQTLMLQNRTLLEQNME 1347
Score = 179 bits (455), Expect = 2e-44
Identities = 271/1223 (22%), Positives = 538/1223 (43%), Gaps = 197/1223 (16%)
Query: 422 HNREVQSLKEQHQKEISELNET-----FLSDSEKEKLTLMFEIQGLK--EQCENLQQEKQ 474
H + + +++H + I EL+E FL + + G+K E ++L E
Sbjct: 196 HLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGS-PGMKRTESRQHLSVELA 254
Query: 475 EAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ--QKLRTAFTEKDA 532
+A LR+ +E +L + ++ Q +K+ Q +++ L + R E DA
Sbjct: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA 314
Query: 533 LLETVNRLQGENEKLLSQQELVPELE---NTIKNLQEKNGVYLLSLSQRDTMLKE-LEG- 587
L E R+ ++ +E + ++E ++ L+E N V L + TML++ LEG
Sbjct: 315 LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL----ETKTMLEDQLEGT 370
Query: 588 -----KINSLTEEKDDFINKLKNSHEEMDNFHKKCER--EERLILELGKK--VEQTIQYN 638
K++ L +E KL + E D KK E EE + LE+ +K +++++
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430
Query: 639 SELEQ-----------------KVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKE 681
ELEQ +VNELT L + + +Q L K + +++ + E
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSS---RLLKLEMENQSLTKTVEELRTTVDSVE 487
Query: 682 VLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDV---------ILKEHITQLEKKLQ 732
++++ + +EN +LS + + L ++ + +K+ + ++KE QLEK ++
Sbjct: 488 GNASKILKMEKENQRLSKKVEILENEI---VQEKQSLQNCQNLSKDLMKEK-AQLEKTIE 543
Query: 733 LMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAK 792
+ E + K+LE E Q L++ S++S ++ KD+ + + ES+ +
Sbjct: 544 TLRENSERQIKILEQENEHL----NQTVSSLRQR-SQISAEARVKDIEKENKILHESIKE 598
Query: 793 INEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE--EI 850
+ + + F++ + ELE +E + EEL++ L E+E LL+K++ +I
Sbjct: 599 TSSKLSKIEFEKRQIKKELEH-----YKEKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 851 QSEK-EALQSDLLEMKNANEKTR--LEN-QNLLIQVEEVSQTCSKSEIHN-------EKE 899
EK EAL+ + E++ N K + L++ +NL Q+E + + S+ + N E
Sbjct: 654 TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 900 KCFIKEHENLKPLLEQKELRDRRAELI----LLKDSLAKSP---------SVKNDPLSS- 945
KC + L+ LE KEL + +L LLK S K+ ++N L
Sbjct: 714 KCASMKMAQLQ--LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 946 -------VKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESL 998
+++LE ++++LE E + ++ + ++K+ + K L+ KE +++++E L
Sbjct: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEELKI----SSKRLEQLEKENKSLEQETSQL 827
Query: 999 RSEKDQLSASMRDLIQGAE-----------SYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
+K QL + L Q AE NL E + S+++ + KE +
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
Query: 1048 EDLTRQLRNSTLQCETINSDNEDLLA-RIETLQSNAKLL----EVQILEVQRAKAMVDKE 1102
++ ++ +T+ +T+ + EDL++ +++T Q N L E++ + + + + + D++
Sbjct: 888 KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947
Query: 1103 LEAEKLQKEQKIKEHATTVNELE-------ELQVQLQKEKKQLQKTMQELELVKKD---- 1151
+ K + K +T LE L+ +L++ Q+ QEL+ VKK+
Sbjct: 948 STDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL 1007
Query: 1152 ---------AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLE----------QEIKI 1192
Q + ++ E +ER +E ++L +++ ++E Q +K
Sbjct: 1008 KQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKT 1067
Query: 1193 QKQKQET----LQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQAS 1248
Q ++ ET LQ +I +LQ +E+NT ++ K + E + T + A
Sbjct: 1068 QLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ 1127
Query: 1249 L---KGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEE 1305
L + LE + V + L + K HE L+ H+R S Y+ ++
Sbjct: 1128 LLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELL---HERQASEYESLIS----- 1179
Query: 1306 CRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKL 1365
+ T+ S ++ +V H L+ + N+ + Q K + E LE ++ + K+
Sbjct: 1180 ------KHGTLKSAHKNLEVE-HRDLEDRYNQLLKQ------KGQLEDLEKMLKVEQEKM 1226
Query: 1366 QDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAE---LREKLCSIQSENMMMK 1422
N + +E + L E+D L ++++L+ET + + L+ L + + E ++
Sbjct: 1227 LLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1286
Query: 1423 SEHTQTVSQLTSQNEVLRNSFRDQVR-------HLQEEHRKTVETLQQQLSKMEAQLFQL 1475
+E ++ Q Q ++ +Q +L+EE+R ++ + Q L L +
Sbjct: 1287 AEFSKLKEQY-QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQI-QTLMLQNRTLLEQ 1344
Query: 1476 KNEPTTRSPVSSQQSLKNLRERR 1498
E V +Q + L E R
Sbjct: 1345 NMESKDLFHVEQRQYIDKLNELR 1367
Score = 171 bits (432), Expect = 7e-42
Identities = 277/1182 (23%), Positives = 511/1182 (43%), Gaps = 164/1182 (13%)
Query: 19 KSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPV-TEGTGDIIKALTER 77
K +LE + E L + ++ M L+ A+S E++ LR K V + + ER
Sbjct: 278 KQELEQMEIE-LKRLQQENMNLLSDARS-ARMYRDELDALREKAVRVDKLESEVSRYKER 335
Query: 78 LDALLLEKAETEQQCLSLKKEN---IKMKQEVEDSVT---KMGDAHKELEQSHINYVKEI 131
L + KA E+ LK++N ++ K +ED + D ELE+ ++ ++
Sbjct: 336 LHDIEFYKARVEE----LKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKL 391
Query: 132 ENLKNELMAVRSKYSE---DKANLQKQLEEAMNTQLELSEQL----KFQNNSEDNVKKLQ 184
+++ E R K E + L+ +++M+ L L +L + SE K L
Sbjct: 392 HDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG 451
Query: 185 EEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNI------IEANSQHYQKNINSLQ 238
E+ ++ ++ + L T +E + TV ++ +E +Q K + L+
Sbjct: 452 HEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 511
Query: 239 EELLQLKAIHQEEVKELMCQ-IEASAKEHEAEINKLNE-LKENLVKQCEASEKNIQKKYE 296
E++Q K Q CQ + + +A++ K E L+EN SE+ I K E
Sbjct: 512 NEIVQEKQSLQN------CQNLSKDLMKEKAQLEKTIETLREN-------SERQI-KILE 557
Query: 297 CELENLRKATSNANQDNQICSILLQENTFVE-QVVNEKVKHLEDTLKELESQHSILKDEV 355
E E+L + S+ Q +QI + ++ E ++++E +K L ++E + +K E
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE- 616
Query: 356 TYMNNLKLKLEMDAQHIKDEFFH---EREDLEFKINELLLAKEEQGCVIEKLKSELAGLN 412
+ + K K E A+ +++E H E E L+ KI L + E+ +E+ SEL N
Sbjct: 617 --LEHYKEKGER-AEELENELHHLEKENELLQKKITNLKITCEKIEA-LEQENSELEREN 672
Query: 413 KQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLK---EQCENL 469
++ T++ L E +KE S+L+E E L L ++ LK + L
Sbjct: 673 RKLKKTLDSFKNLTFQL-ESLEKENSQLDE--------ENLELRRNVESLKCASMKMAQL 723
Query: 470 QQEKQEAILNYESLREIMEILQTEL----------------GESAGKISQEFESMKQQQA 513
Q E +E E L++ +E+L+ + K + QQ
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 514 SDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLL 573
S++ +L+ + +T + L + RL+ ++ S ++ +LE K L+++N
Sbjct: 784 SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ 843
Query: 574 SLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQ 633
+DT L+E KI +L +E K +E+ + + C R + L E + V++
Sbjct: 844 QAEIKDTTLEENNVKIGNLEKEN-------KTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 634 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEE 693
+++ V + E LK + N+ LEKL +++ + +KE L L++E
Sbjct: 897 A---TIDIKTLVTLREDLVSEKLKTQQMNND-LEKLTHELEKIGLNKERL------LHDE 946
Query: 694 NNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKL 753
+ S K L LE L +K I +E I LE +L EE N N+ L Q+L
Sbjct: 947 QSTDDSRYKLLESKLESTL-KKSLEIKEEKIAALEARL----EESTNYNQQLR----QEL 997
Query: 754 FVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGE--SLAKINEEKCNLAFQRDEKVLEL 811
+ Y LK+ EE+ V + GE + ++E + ++++E+
Sbjct: 998 KTVKKNYEALKQ------RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1051
Query: 812 EKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKT 871
E+ LQ E + LK+ L+ E + L+ ++ +Q + +LQ ++ N K
Sbjct: 1052 ERNNATLQAEK----QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKL 1107
Query: 872 RLEN-----QNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELI 926
++EN Q+ + + +S + NE E IKE E+LK L + + EL+
Sbjct: 1108 QVENSTLNSQSTSLMNQNAQLLIQQSSLENENES-VIKEREDLKSLYDSLIKDHEKLELL 1166
Query: 927 LLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKI-----------KLVAV 975
+ S +S L+ +NLE E ++ E++ N++ K++ V
Sbjct: 1167 -----HERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKV 1221
Query: 976 KAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAE-------SYKNLLLEYEK 1028
+ +K L K +TV E + L E D+L+ + L++ E + K+LL +
Sbjct: 1222 EQEKML-LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL 1280
Query: 1029 QSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCE-------TINSDNEDLLARIETLQSN 1081
+ +L+ E + +++ + +L N QCE + +N LL +I+TL
Sbjct: 1281 EQTRLEAEFSKLKEQYQQLDITSTKLNN---QCELLSQLKGNLEEENRHLLDQIQTLMLQ 1337
Query: 1082 AKLLEVQILEVQ-----RAKAMVDK--ELEAEKLQKEQKIKE 1116
+ L Q +E + + +DK EL +K + E+KI +
Sbjct: 1338 NRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1379
Score = 169 bits (429), Expect = 2e-41
Identities = 260/1214 (21%), Positives = 528/1214 (43%), Gaps = 186/1214 (15%)
Query: 529 EKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDT--MLKELE 586
+K+ +E + L + + ++ + E+ + +N+ + + + +SQ D +LK +
Sbjct: 137 KKEEFIERIQGLDFDTKAAVAAH--IQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMA 194
Query: 587 GKINSLTEEKDDFINKLKNSHEEMDNFH------------------KKCEREERLILELG 628
+ L +E+D+ + EE D H K+ E + L +EL
Sbjct: 195 LHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELA 254
Query: 629 KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQ-MKVLSEDKE--VLSA 685
+ + ELE+K +L + +E +Q + +L++L + M +LS+ + +
Sbjct: 255 DAKAKIRRLRQELEEKTEQLL----DCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310
Query: 686 EVKSLYEENNKLSSEKKQLSR------DLEVFLSQKEDV-----ILKEHITQLEKKLQLM 734
E+ +L E+ ++ + ++SR D+E + ++ E++ +L E T LE +L+
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 370
Query: 735 VEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKIN 794
D L++L E E +Q +K +L+ E+ D + K +
Sbjct: 371 RARSDKLHEL-EKENLQ---LKAKLHDM------EMERDMDRKKI--------------- 405
Query: 795 EEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEK 854
E+++E ++ Q++S+ + SL +E E++ EL E + +
Sbjct: 406 -----------EELMEENMTLEMAQKQSMDE-----SLHLGWELEQISRTSELSE--APQ 447
Query: 855 EALQSDLLEMKNANE-KTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913
++L ++ E+ ++ K +ENQ+L VEE+ T E + K KE++ L +
Sbjct: 448 KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV 507
Query: 914 EQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLE-------KECKEKEEK 966
E E E++ K SL ++ D + +LE+ IE L K +++ E
Sbjct: 508 EILE-----NEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEH 562
Query: 967 INKI-----KLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKN 1021
+N+ + + A+ + KE + + E ++ S+ ++ R + + E YK
Sbjct: 563 LNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK- 621
Query: 1022 LLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI------NSDNEDLLARI 1075
E +++E+L+ E ++ E E L +++ N + CE I NS+ E ++
Sbjct: 622 ---EKGERAEELENE---LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
Query: 1076 ETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEK 1135
+ + K L Q+ +++ + +D+E E + + +K + + +L+ +L+ EK
Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLENKELESEK 734
Query: 1136 KQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQ 1195
+QL+K LEL+K ++T + + + + L + L N N KI+ LE E++ +
Sbjct: 735 EQLKKG---LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
Query: 1196 KQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDH--LILQASLK--- 1250
+ +TLQ+ + L+ S ++ E+ + K L +T + D KQ E ++ L QA +K
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 1251 --------GELEAS----QQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQR 1298
G LE +++ +YK + E K ++ L A +TL ++
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRL-KELEKENKELVKRATIDIKTLVTLRED 910
Query: 1299 VTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQER------E 1352
+ + + + + + +T E E + +L +++ S+ + +K E E
Sbjct: 911 LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLE 970
Query: 1353 HLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHN------------------ 1394
E I L+ +L++S N Q EL+T++ ++ L +R +
Sbjct: 971 IKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKW 1030
Query: 1395 -KMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEE 1453
+ QET + +++++L ++ N +++E +QL Q E N+ + Q+ LQ
Sbjct: 1031 ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL-KQLETQNNNLQAQILALQ-- 1087
Query: 1454 HRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTRE 1513
R+TV +LQ+Q + ++ Q +L+ E +T + S SL N +N L L+ ++ E
Sbjct: 1088 -RQTV-SLQEQNTTLQTQNAKLQVENSTLN--SQSTSLMN----QNAQL-LIQQSSLENE 1138
Query: 1514 EGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSAD 1573
ESV +SL L KLE E L+ K + +
Sbjct: 1139 ---------NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHK 1189
Query: 1574 HLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGS 1633
+L R+ E L++Q K ++ LE+ + E+ LE + + + K
Sbjct: 1190 NLEVEHRDLEDRYNQLLKQ----KGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCG 1245
Query: 1634 ERERLLPVINTMLQ 1647
E +RL + +L+
Sbjct: 1246 ENDRLNHTYSQLLK 1259
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.124 0.313
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,041,954
Number of Sequences: 37866
Number of extensions: 2598510
Number of successful extensions: 56499
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 729
Number of HSP's successfully gapped in prelim test: 1633
Number of HSP's that attempted gapping in prelim test: 14472
Number of HSP's gapped (non-prelim): 15084
length of query: 1684
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1568
effective length of database: 13,855,062
effective search space: 21724737216
effective search space used: 21724737216
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.