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Search of human proteins with 31563330
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
(2817 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] 5574 0.0
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] 5520 0.0
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] 2061 0.0
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo... 597 e-170
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor... 597 e-170
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens] 588 e-167
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor... 585 e-166
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor... 585 e-166
gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isoofor... 574 e-163
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 189 3e-47
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 189 3e-47
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 189 3e-47
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 178 8e-44
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 178 8e-44
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 169 5e-41
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 82 1e-14
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ... 82 1e-14
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H... 82 1e-14
gi|38373682 pleckstrin homology domain containing family G membe... 79 8e-14
gi|111154084 pleckstrin homology domain containing family G memb... 79 8e-14
gi|111154088 pleckstrin homology domain containing family G memb... 79 8e-14
gi|111154080 pleckstrin homology domain containing family G memb... 79 8e-14
gi|111154078 pleckstrin homology domain containing family G memb... 79 8e-14
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 78 1e-13
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [... 78 1e-13
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 77 3e-13
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 76 5e-13
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 75 1e-12
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 75 1e-12
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 72 1e-11
>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
Length = 2817
Score = 5574 bits (14460), Expect = 0.0
Identities = 2817/2817 (100%), Positives = 2817/2817 (100%)
Query: 1 MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP 60
MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP
Sbjct: 1 MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP 60
Query: 61 GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD 120
GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD
Sbjct: 61 GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD 120
Query: 121 QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT 180
QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT
Sbjct: 121 QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT 180
Query: 181 WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG 240
WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG
Sbjct: 181 WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG 240
Query: 241 DCSVRHHRELDIYTLTSESDSHHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQMDSLMPL 300
DCSVRHHRELDIYTLTSESDSHHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQMDSLMPL
Sbjct: 241 DCSVRHHRELDIYTLTSESDSHHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQMDSLMPL 300
Query: 301 MMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV 360
MMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV
Sbjct: 301 MMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV 360
Query: 361 EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGN 420
EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGN
Sbjct: 361 EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGN 420
Query: 421 RNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDTAG 480
RNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDTAG
Sbjct: 421 RNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDTAG 480
Query: 481 EMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA 540
EMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA
Sbjct: 481 EMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA 540
Query: 541 SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDG 600
SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDG
Sbjct: 541 SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDG 600
Query: 601 LEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDK 660
LEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDK
Sbjct: 601 LEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDK 660
Query: 661 LCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD 720
LCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD
Sbjct: 661 LCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD 720
Query: 721 PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVI 780
PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVI
Sbjct: 721 PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVI 780
Query: 781 SDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEPDTRPL 840
SDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEPDTRPL
Sbjct: 781 SDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEPDTRPL 840
Query: 841 EDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA 900
EDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA
Sbjct: 841 EDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA 900
Query: 901 TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDT 960
TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDT
Sbjct: 901 TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDT 960
Query: 961 QQFHEKSISADCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPP 1020
QQFHEKSISADCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPP
Sbjct: 961 QQFHEKSISADCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPP 1020
Query: 1021 GASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA 1080
GASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA
Sbjct: 1021 GASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA 1080
Query: 1081 CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKA 1140
CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKA
Sbjct: 1081 CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKA 1140
Query: 1141 VTDPQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKELPTDME 1200
VTDPQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKELPTDME
Sbjct: 1141 VTDPQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKELPTDME 1200
Query: 1201 LSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI 1260
LSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI
Sbjct: 1201 LSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI 1260
Query: 1261 EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATG 1320
EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATG
Sbjct: 1261 EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATG 1320
Query: 1321 SLAGCFAGREEPEKIILPVQGPEPAAEMPDVKAEDEVDFRASSISEEVAVGSIAATLKMK 1380
SLAGCFAGREEPEKIILPVQGPEPAAEMPDVKAEDEVDFRASSISEEVAVGSIAATLKMK
Sbjct: 1321 SLAGCFAGREEPEKIILPVQGPEPAAEMPDVKAEDEVDFRASSISEEVAVGSIAATLKMK 1380
Query: 1381 QGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSD 1440
QGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSD
Sbjct: 1381 QGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSD 1440
Query: 1441 SDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPN 1500
SDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPN
Sbjct: 1441 SDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPN 1500
Query: 1501 RSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSP 1560
RSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSP
Sbjct: 1501 RSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSP 1560
Query: 1561 FRRHSWGPGKNAASDAEMNHRSMSWCPSGVQYSAGLSADFNYRSFSLEGLTGGAGVGNKP 1620
FRRHSWGPGKNAASDAEMNHRSMSWCPSGVQYSAGLSADFNYRSFSLEGLTGGAGVGNKP
Sbjct: 1561 FRRHSWGPGKNAASDAEMNHRSMSWCPSGVQYSAGLSADFNYRSFSLEGLTGGAGVGNKP 1620
Query: 1621 SSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNY 1680
SSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNY
Sbjct: 1621 SSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNY 1680
Query: 1681 CTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKD 1740
CTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKD
Sbjct: 1681 CTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKD 1740
Query: 1741 SEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSS 1800
SEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSS
Sbjct: 1741 SEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSS 1800
Query: 1801 IPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTS 1860
IPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTS
Sbjct: 1801 IPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTS 1860
Query: 1861 SLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGND 1920
SLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGND
Sbjct: 1861 SLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGND 1920
Query: 1921 ENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESW 1980
ENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESW
Sbjct: 1921 ENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESW 1980
Query: 1981 SRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVE 2040
SRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVE
Sbjct: 1981 SRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVE 2040
Query: 2041 KLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKT 2100
KLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKT
Sbjct: 2041 KLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKT 2100
Query: 2101 YGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVL 2160
YGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVL
Sbjct: 2101 YGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVL 2160
Query: 2161 FQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRM 2220
FQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRM
Sbjct: 2161 FQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRM 2220
Query: 2221 KSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQ 2280
KSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQ
Sbjct: 2221 KSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQ 2280
Query: 2281 KSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLN 2340
KSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLN
Sbjct: 2281 KSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLN 2340
Query: 2341 RDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED 2400
RDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED
Sbjct: 2341 RDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED 2400
Query: 2401 CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVV 2460
CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVV
Sbjct: 2401 CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVV 2460
Query: 2461 GPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKR 2520
GPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKR
Sbjct: 2461 GPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKR 2520
Query: 2521 NSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRS 2580
NSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRS
Sbjct: 2521 NSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRS 2580
Query: 2581 LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE 2640
LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE
Sbjct: 2581 LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE 2640
Query: 2641 REELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMR 2700
REELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMR
Sbjct: 2641 REELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMR 2700
Query: 2701 IPSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKG 2760
IPSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKG
Sbjct: 2701 IPSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKG 2760
Query: 2761 PEGQSQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 2817
PEGQSQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC
Sbjct: 2761 PEGQSQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 2817
>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
Length = 2813
Score = 5520 bits (14319), Expect = 0.0
Identities = 2798/2817 (99%), Positives = 2800/2817 (99%), Gaps = 4/2817 (0%)
Query: 1 MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP 60
MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP
Sbjct: 1 MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP 60
Query: 61 GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD 120
GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD
Sbjct: 61 GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD 120
Query: 121 QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT 180
QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT
Sbjct: 121 QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT 180
Query: 181 WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG 240
WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG
Sbjct: 181 WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG 240
Query: 241 DCSVRHHRELDIYTLTSESDSHHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQMDSLMPL 300
DCSVRHHRELDIYTLTSESDSHHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQMDSLMPL
Sbjct: 241 DCSVRHHRELDIYTLTSESDSHHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQMDSLMPL 300
Query: 301 MMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV 360
MMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV
Sbjct: 301 MMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV 360
Query: 361 EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGN 420
EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGN
Sbjct: 361 EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGN 420
Query: 421 RNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDTAG 480
RNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDTAG
Sbjct: 421 RNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDTAG 480
Query: 481 EMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA 540
EMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA
Sbjct: 481 EMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA 540
Query: 541 SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDG 600
SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDG
Sbjct: 541 SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDG 600
Query: 601 LEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDK 660
LEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDK
Sbjct: 601 LEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDK 660
Query: 661 LCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD 720
LCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD
Sbjct: 661 LCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD 720
Query: 721 PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVI 780
PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVI
Sbjct: 721 PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVI 780
Query: 781 SDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEPDTRPL 840
SDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEPDTRPL
Sbjct: 781 SDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEPDTRPL 840
Query: 841 EDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA 900
EDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA
Sbjct: 841 EDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA 900
Query: 901 TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDT 960
TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDT
Sbjct: 901 TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDT 960
Query: 961 QQFHEKSISADCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPP 1020
QQFHEKSISADCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPP
Sbjct: 961 QQFHEKSISADCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPP 1020
Query: 1021 GASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA 1080
GASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA
Sbjct: 1021 GASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA 1080
Query: 1081 CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKA 1140
CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKA
Sbjct: 1081 CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKA 1140
Query: 1141 VTDPQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKELPTDME 1200
VTDPQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKELPTDME
Sbjct: 1141 VTDPQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKELPTDME 1200
Query: 1201 LSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI 1260
LSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI
Sbjct: 1201 LSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI 1260
Query: 1261 EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATG 1320
EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATG
Sbjct: 1261 EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATG 1320
Query: 1321 SLAGCFAGREEPEKIILPVQGPEPAAEMPDVKAEDEVDFRASSISEEVAVGSIAATLKMK 1380
SLAGCFAGREEPEKIILPVQGPEPAAEMPDVKAEDEVDFRASSISEEVAVGSIAATLKMK
Sbjct: 1321 SLAGCFAGREEPEKIILPVQGPEPAAEMPDVKAEDEVDFRASSISEEVAVGSIAATLKMK 1380
Query: 1381 QGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSD 1440
QGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSD
Sbjct: 1381 QGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSD 1440
Query: 1441 SDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPN 1500
SDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPN
Sbjct: 1441 SDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPN 1500
Query: 1501 RSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSP 1560
RSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSP
Sbjct: 1501 RSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSP 1560
Query: 1561 FRRHSWGPGKNAASDAEMNHRSMSWCPSGVQYSAGLSADFNYRSFSLEGLTGGAGVGNKP 1620
FRRHSWGPGKNAASDAEMNHRS V + + RSFSLEGLTGGAGVGNKP
Sbjct: 1561 FRRHSWGPGKNAASDAEMNHRSSMRVLGDVVRRPPI----HRRSFSLEGLTGGAGVGNKP 1616
Query: 1621 SSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNY 1680
SSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNY
Sbjct: 1617 SSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNY 1676
Query: 1681 CTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKD 1740
CTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKD
Sbjct: 1677 CTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKD 1736
Query: 1741 SEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSS 1800
SEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSS
Sbjct: 1737 SEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSS 1796
Query: 1801 IPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTS 1860
IPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTS
Sbjct: 1797 IPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTS 1856
Query: 1861 SLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGND 1920
SLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGND
Sbjct: 1857 SLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGND 1916
Query: 1921 ENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESW 1980
ENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESW
Sbjct: 1917 ENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESW 1976
Query: 1981 SRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVE 2040
SRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVE
Sbjct: 1977 SRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVE 2036
Query: 2041 KLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKT 2100
KLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKT
Sbjct: 2037 KLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKT 2096
Query: 2101 YGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVL 2160
YGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVL
Sbjct: 2097 YGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVL 2156
Query: 2161 FQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRM 2220
FQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRM
Sbjct: 2157 FQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRM 2216
Query: 2221 KSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQ 2280
KSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQ
Sbjct: 2217 KSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQ 2276
Query: 2281 KSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLN 2340
KSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLN
Sbjct: 2277 KSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLN 2336
Query: 2341 RDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED 2400
RDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED
Sbjct: 2337 RDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED 2396
Query: 2401 CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVV 2460
CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVV
Sbjct: 2397 CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVV 2456
Query: 2461 GPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKR 2520
GPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKR
Sbjct: 2457 GPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKR 2516
Query: 2521 NSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRS 2580
NSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRS
Sbjct: 2517 NSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRS 2576
Query: 2581 LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE 2640
LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE
Sbjct: 2577 LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE 2636
Query: 2641 REELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMR 2700
REELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMR
Sbjct: 2637 REELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMR 2696
Query: 2701 IPSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKG 2760
IPSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKG
Sbjct: 2697 IPSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKG 2756
Query: 2761 PEGQSQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 2817
PEGQSQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC
Sbjct: 2757 PEGQSQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 2813
>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
Length = 1058
Score = 2061 bits (5339), Expect = 0.0
Identities = 1058/1058 (100%), Positives = 1058/1058 (100%)
Query: 1760 MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNK 1819
MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNK
Sbjct: 1 MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNK 60
Query: 1820 DAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPR 1879
DAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPR
Sbjct: 61 DAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPR 120
Query: 1880 SAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNK 1939
SAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNK
Sbjct: 121 SAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNK 180
Query: 1940 ISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKR 1999
ISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKR
Sbjct: 181 ISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKR 240
Query: 2000 QEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQR 2059
QEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQR
Sbjct: 241 QEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQR 300
Query: 2060 ILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY 2119
ILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY
Sbjct: 301 ILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY 360
Query: 2120 AKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLA 2179
AKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLA
Sbjct: 361 AKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLA 420
Query: 2180 QSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRD 2239
QSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRD
Sbjct: 421 QSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRD 480
Query: 2240 GSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEE 2299
GSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEE
Sbjct: 481 GSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEE 540
Query: 2300 KGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLD 2359
KGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLD
Sbjct: 541 KGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLD 600
Query: 2360 TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEAL 2419
TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEAL
Sbjct: 601 TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEAL 660
Query: 2420 KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQ 2479
KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQ
Sbjct: 661 KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQ 720
Query: 2480 MNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSAL 2539
MNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSAL
Sbjct: 721 MNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSAL 780
Query: 2540 QGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL 2599
QGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL
Sbjct: 781 QGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL 840
Query: 2600 EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR 2659
EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR
Sbjct: 841 EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR 900
Query: 2660 AAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSI 2719
AAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSI
Sbjct: 901 AAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSI 960
Query: 2720 AKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFG 2779
AKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFG
Sbjct: 961 AKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFG 1020
Query: 2780 LTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 2817
LTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC
Sbjct: 1021 LTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 1058
>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform b
[Homo sapiens]
Length = 1173
Score = 597 bits (1540), Expect = e-170
Identities = 378/931 (40%), Positives = 549/931 (58%), Gaps = 86/931 (9%)
Query: 1920 DENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAES 1979
DE S KF + DSL S + +TES+ E D L + E + + EAES
Sbjct: 188 DEADSAFLKFKQTADDSL---SLTSPNTESIFVE----DPYTASLRSEIESDGHEFEAES 240
Query: 1980 WSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMV 2039
WS +D+ + K+QK++VVKRQ+V+YELMQTE HHVRTLKIM VYS+ + +L F + +
Sbjct: 241 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 300
Query: 2040 EKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKK 2099
+LFPC D+L+ HS F R+ ER++ESL + S++N++I++IGD+LV QFSGEN ER+K+
Sbjct: 301 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 360
Query: 2100 TYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPV 2159
YG FC HN++V+++K L ++K+FQ +KK + S+VRRLG+ ECILLVTQRITKYPV
Sbjct: 361 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 420
Query: 2160 LFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMR 2219
L +RI+Q T+ + EDL Q+L+L+KD+I VD+KV+ EK RL EI K D KS +
Sbjct: 421 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 480
Query: 2220 MKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLD 2279
+K+G F KED+ +++L +G + K +GRLK++ A+LLTD+L+ LQEKDQKY+FAS+D
Sbjct: 481 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 540
Query: 2280 QKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2339
K VISL+KLIVREVA+EEK +FLIS + PEM E++ SSKE+RN+W+ IQ + +
Sbjct: 541 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 600
Query: 2340 NRDEDEGIPSENEEEKKMLD---TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECS-- 2394
DE+EG S EEE+K+++ TR R+ +E+L KDQ I L EK+ I+ +MAE
Sbjct: 601 -PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGL 659
Query: 2395 TPLPEDCSPTHSPRVLFR-SNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSS 2453
LP+ PR LFR + E L+G ++KSA++E+E +Q L+ LG G
Sbjct: 660 EDLPQ-------PRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQA--- 709
Query: 2454 PIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEE-------------GDDGQDLRRT 2500
+D PRRAETF G+D G K++ + DL+ +
Sbjct: 710 ---EDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLS 766
Query: 2501 ESDSGLKKGGNANLVFMLKRNSE---------QVVQSVVHLYELLSALQGVVLQQDSYIE 2551
+SD + +V S+ ++VQ + L +LL LQ V+ QDSY+E
Sbjct: 767 DSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVE 826
Query: 2552 DQKLVLSERALTRSL--SRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREW 2609
Q+ + ER L +R + L+EQE+QR+ EKQR++ A L+K Q+Q E++R ERE
Sbjct: 827 TQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERER 886
Query: 2610 EARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQ 2669
+ + +EL A L +RE E +Q ++ LE+ER EL++++ YQ+DLERLR AQ+ +ERE+
Sbjct: 887 QWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERER 946
Query: 2670 EQLRREAERLSQRQTE---------RDLCQVSHP---HTKLMRIP--SFFPSPEEPPSPS 2715
E+L RL ++ T + SHP + + + P S PS P
Sbjct: 947 ERLEL-LRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAE 1005
Query: 2716 APSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSAST 2775
P +A+ S +E +R K P +LS+T+Q + Q Q P +AST
Sbjct: 1006 RPEVARRDSAPTE----------NRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAAST 1055
Query: 2776 RLFGLTKPKEKKEKKKKNKTSRSQPGDGPAS 2806
K K K K+ SQ + AS
Sbjct: 1056 ----------KGGKDKGGKSRGSQRWESSAS 1076
>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
[Homo sapiens]
Length = 1015
Score = 597 bits (1540), Expect = e-170
Identities = 378/931 (40%), Positives = 549/931 (58%), Gaps = 86/931 (9%)
Query: 1920 DENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAES 1979
DE S KF + DSL S + +TES+ E D L + E + + EAES
Sbjct: 30 DEADSAFLKFKQTADDSL---SLTSPNTESIFVE----DPYTASLRSEIESDGHEFEAES 82
Query: 1980 WSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMV 2039
WS +D+ + K+QK++VVKRQ+V+YELMQTE HHVRTLKIM VYS+ + +L F + +
Sbjct: 83 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 142
Query: 2040 EKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKK 2099
+LFPC D+L+ HS F R+ ER++ESL + S++N++I++IGD+LV QFSGEN ER+K+
Sbjct: 143 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 202
Query: 2100 TYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPV 2159
YG FC HN++V+++K L ++K+FQ +KK + S+VRRLG+ ECILLVTQRITKYPV
Sbjct: 203 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 262
Query: 2160 LFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMR 2219
L +RI+Q T+ + EDL Q+L+L+KD+I VD+KV+ EK RL EI K D KS +
Sbjct: 263 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 322
Query: 2220 MKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLD 2279
+K+G F KED+ +++L +G + K +GRLK++ A+LLTD+L+ LQEKDQKY+FAS+D
Sbjct: 323 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 382
Query: 2280 QKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2339
K VISL+KLIVREVA+EEK +FLIS + PEM E++ SSKE+RN+W+ IQ + +
Sbjct: 383 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 442
Query: 2340 NRDEDEGIPSENEEEKKMLD---TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECS-- 2394
DE+EG S EEE+K+++ TR R+ +E+L KDQ I L EK+ I+ +MAE
Sbjct: 443 -PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGL 501
Query: 2395 TPLPEDCSPTHSPRVLFR-SNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSS 2453
LP+ PR LFR + E L+G ++KSA++E+E +Q L+ LG G
Sbjct: 502 EDLPQ-------PRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQA--- 551
Query: 2454 PIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEE-------------GDDGQDLRRT 2500
+D PRRAETF G+D G K++ + DL+ +
Sbjct: 552 ---EDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLS 608
Query: 2501 ESDSGLKKGGNANLVFMLKRNSE---------QVVQSVVHLYELLSALQGVVLQQDSYIE 2551
+SD + +V S+ ++VQ + L +LL LQ V+ QDSY+E
Sbjct: 609 DSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVE 668
Query: 2552 DQKLVLSERALTRSL--SRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREW 2609
Q+ + ER L +R + L+EQE+QR+ EKQR++ A L+K Q+Q E++R ERE
Sbjct: 669 TQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERER 728
Query: 2610 EARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQ 2669
+ + +EL A L +RE E +Q ++ LE+ER EL++++ YQ+DLERLR AQ+ +ERE+
Sbjct: 729 QWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERER 788
Query: 2670 EQLRREAERLSQRQTE---------RDLCQVSHP---HTKLMRIP--SFFPSPEEPPSPS 2715
E+L RL ++ T + SHP + + + P S PS P
Sbjct: 789 ERLEL-LRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAE 847
Query: 2716 APSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSAST 2775
P +A+ S +E +R K P +LS+T+Q + Q Q P +AST
Sbjct: 848 RPEVARRDSAPTE----------NRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAAST 897
Query: 2776 RLFGLTKPKEKKEKKKKNKTSRSQPGDGPAS 2806
K K K K+ SQ + AS
Sbjct: 898 ----------KGGKDKGGKSRGSQRWESSAS 918
>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
Length = 1651
Score = 588 bits (1516), Expect = e-167
Identities = 400/1169 (34%), Positives = 624/1169 (53%), Gaps = 111/1169 (9%)
Query: 1557 SLSPFRRHSWGPGKNAASDAEMNHRSMSWCPSGVQYSAGL------SADFNYRSFSLEGL 1610
S+ P + G A + M+ S C S + S G + RS SL+ L
Sbjct: 425 SVYPLSENVEGTAHTEAQQSFMSPSSS--CASNLNLSFGWHGFEKEQSHLKKRSSSLDAL 482
Query: 1611 TGGA-GVGNKPSSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQI 1669
+ G G+ S + + + R + +DS + +E D + E +
Sbjct: 483 DADSEGEGHSEPSHICYTPGSQSSSRTGIPSGDELDSFETNTEPDFNISRAESLPLSSNL 542
Query: 1670 CHRS------KQQGFNYCTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTES 1723
+ + + ++ + IS T+ + +T+ +S + +
Sbjct: 543 QSKESLLSGVRSRSYSCSSPKISLGKTRLVRELTVC-----SSSEEQRAYSLSEPPRENR 597
Query: 1724 ITEENYNFLPHSPSKKDSEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDS 1783
I EE ++ P+K +SE KVSRTFS++ N+M+S + +K K K KD+
Sbjct: 598 IQEEEWDKYI-IPAKSESE---KYKVSRTFSFLMNRMTSPR---------NKSKTKSKDA 644
Query: 1784 KDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCA 1843
KDKEK +N H F+ G + C C K K++ C+NC+A VHKGC+++ +C
Sbjct: 645 KDKEK----LNRHQFAPGTFSGVLQCLVCDKTLLGKESLQCSNCNANVHKGCKDAAPACT 700
Query: 1844 KVKMKQ------------------PKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAVLLV 1885
K ++ P+ L H +SS+P + P+ +E L
Sbjct: 701 KKFQEKYNKNKPQTILGNSSFRDIPQPGLSLHPSSSVPVGL----PTGRRETVGQVHPLS 756
Query: 1886 DETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNE 1945
T + + RRS S+ E+ N+ + SHS + L + +
Sbjct: 757 RSVPGTTLESFRRSATSLE---------------SESDHNSCRSRSHSDELLQSMGS-SP 800
Query: 1946 STESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYE 2005
STES E D+ + L D ++++ EAESWS ++D F +Q+KDV+KRQ+VI+E
Sbjct: 801 STESFIME----DVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFE 856
Query: 2006 LMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKK 2065
LMQTE HH++TL IMS ++ +GM +L + V+K+FPCLDEL+ IH FF + ER++
Sbjct: 857 LMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQ 916
Query: 2066 ESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRF 2125
ES S++NF+I RIGD+LV QFS ENA ++KK YG+FC H ++VN FK+L ++K+F
Sbjct: 917 ESCAG-SDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQ-QNKKF 974
Query: 2126 QAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLV 2185
Q F+K + S+ + RR GIPECILLVTQRITKYPVL +RILQ TK+ E +DL ++L L+
Sbjct: 975 QNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLI 1034
Query: 2186 KDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDL--KRKKLVRDGSVF 2243
KD+I VD KV YEK + EI K ++K+ ++K+G +F K+ L + + L+ DG V+
Sbjct: 1035 KDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVY 1094
Query: 2244 LKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEEKGLF 2303
K A GR K++ A+LLTD+L+FLQEKDQKYIFA++DQK +VISL+KLI REVA+EE+G+F
Sbjct: 1095 WKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMF 1154
Query: 2304 LISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLDTRA- 2362
LIS PEM E+H +SKEERN+W++ IQ + + +E G SE++E+K+ + R
Sbjct: 1155 LISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESC-PEEKGGRTSESDEDKRKAEARVA 1213
Query: 2363 --RELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTH-SPRVLFRSNTEEAL 2419
++ +E L +DQ+I LEEK I+ ++ E S H P +L + + E
Sbjct: 1214 KIQQCQEILTNQDQQICAYLEEKLHIYAELGELS-----GFEDVHLEPHLLIKPDPGEPP 1268
Query: 2420 KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFD--- 2476
+ L+ +A+ E E LQ V + G + + V+ A+T D
Sbjct: 1269 QAASLLAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVL--------ADTLSSHDVPG 1320
Query: 2477 SHQMNASKGGEKEEG--DDGQDLRRTESDSGLKKGGNANLVFMLKRNSE-QVVQSVVHLY 2533
S + GG + G D ++ +D + G +S+ +++Q++ +L
Sbjct: 1321 SPTASLVTGGREGRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQSEIIQAIQNLT 1380
Query: 2534 ELLSALQGVVLQQDSYIEDQKLVLSER---ALTRSLSRPSSLIEQEKQRSLEKQRQDLAN 2590
LL +LQ + QDS+IE +LVL ++ +L S+ R L + +K R ++Q ++LAN
Sbjct: 1381 RLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPL-QDQKSRDADRQHEELAN 1439
Query: 2591 LQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGT 2650
+ + Q Q +E+RR R E ++R RE+ L +RE E Q ++ L + R EL +
Sbjct: 1440 VHQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDLQLQE 1499
Query: 2651 YQYDLERLRAAQKQLEREQEQLRREAERL 2679
YQ+ LERLR Q+ +EREQ ++R + L
Sbjct: 1500 YQHSLERLREGQRLVEREQARMRAQQSLL 1528
Score = 141 bits (356), Expect = 8e-33
Identities = 87/263 (33%), Positives = 133/263 (50%), Gaps = 4/263 (1%)
Query: 1 MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP 60
M+L+ +APLYG ++ + +D FY + GS RH ++ + L++ P
Sbjct: 1 MELSCSEAPLYGQMMIYAKFDKNVYLPEDAEFYFTYDGSHQRHVMIAERIEDNVLQSSVP 60
Query: 61 GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD 120
GH ETV V +C EG + +V + A A+ L T A A + L
Sbjct: 61 GHGLQETVTVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARLLVTQANRLTACSHQTLLT 120
Query: 121 QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT 180
+G + +LD++LVLA HL+LP EW VLG+ SL + RE+L+H A+R GL +L+
Sbjct: 121 PFALTAGALPALDEELVLALTHLELPLEWTVLGS-SSLEVSSHRESLLHLAMRWGLAKLS 179
Query: 181 WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG 240
F L PGG AL++ N+EGATP+ LAL G+ KL + +T S+S +
Sbjct: 180 QFFLCLPGGVQALALPNEEGATPLDLALREGHSKLVEDVTNFQGRWSPSFSRVQLS---E 236
Query: 241 DCSVRHHRELDIYTLTSESDSHH 263
+ S+ + + TLT + H
Sbjct: 237 EASLHYIHSSETLTLTLNHTAEH 259
>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
[Homo sapiens]
Length = 986
Score = 585 bits (1508), Expect = e-166
Identities = 371/908 (40%), Positives = 550/908 (60%), Gaps = 58/908 (6%)
Query: 1749 VSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPIS 1808
+SR S + ++ S++ K +EK+K+KE KD + NGH F++I V G
Sbjct: 1 MSRIESLTRARIDRSRELASKTREKEKMKEA--------KDARYTNGHLFTTISVSGMTM 52
Query: 1809 CSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMR 1868
C C K T K+A C C+ +H C+++LA+C KVK KQ K +L ++T+ L +V +R
Sbjct: 53 CYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTA-LQSVSLR 111
Query: 1869 NKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWK 1928
+K + +ERP SA+ D + + +RR + S+SL+KSVS NI G NDE+ +
Sbjct: 112 SKTTI-RERPSSAIYPSDSFRQS-LLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRR 169
Query: 1929 FLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKF 1988
LS STDSLN ++ S ESL DE ++ +L+ DFE++ K A+SWS +DS F
Sbjct: 170 ILSQSTDSLNMRNRTL-SVESLIDEA---EVIYSELMSDFEMDEKDFAADSWSLAVDSSF 225
Query: 1989 LKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDE 2048
L+Q KK+V+K+Q+VIYEL+QTE HHVRTLKIM+ ++ GM+ +L E +V+ LFPC+DE
Sbjct: 226 LQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDE 285
Query: 2049 LISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQH 2108
L IH++F ++LER++++L S +NF+I R+GD+L++QFSG +AE++ KTY +FC +H
Sbjct: 286 LSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRH 345
Query: 2109 NQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCT 2168
++++ +K+LYA+DKRFQ F++K +V++R G+ ECILLVTQRITKYP+L RILQ +
Sbjct: 346 SKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHS 405
Query: 2169 KDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAK 2228
E E++DL +L LVK+++ VD + EK RL EIY + D ++ + F +
Sbjct: 406 HGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGR 465
Query: 2229 EDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLK 2288
E+L R+KL+ DG + K A GR K+V +L+TD+LVFLQEKDQKYIF +LD K +V+SL+
Sbjct: 466 EELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSVVSLQ 524
Query: 2289 KLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIP 2348
LIVR++A++EKG+FLIS PEM EVH +S+++R++WI++IQ ++ T ED +
Sbjct: 525 NLIVRDIANQEKGMFLIS--AAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPL- 581
Query: 2349 SENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED-----CSP 2403
E E+E + R +K +L QKD+ ++ LL EK +F +M ED P
Sbjct: 582 IETEDEAYL-----RRIKMELQQKDRALVELLREKVGLFAEMTHFQA--EEDGGSGMALP 634
Query: 2404 THSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPV 2463
T PR LFRS + E+ +G L++ AI EVE L+ L+ G G L T P
Sbjct: 635 T-LPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGP-GVELLLTPREP--------- 683
Query: 2464 SLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLK-KGGNANLVFMLKRNS 2522
+LP ++ GG S + A+ GE + +L R +SDS + + GN L+
Sbjct: 684 ALPLEPDS-GGNTSPGVTAN--GEARTFNGSIELCRADSDSSQRDRNGN-----QLRSPQ 735
Query: 2523 EQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER--ALTRSLSRPSSLIEQ-EKQR 2579
E+ +Q +V+LY LL LQ V QQD+ +E + ER L R+ SR
Sbjct: 736 EEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPV 795
Query: 2580 SLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEK 2639
+ EKQ +LA LQ+Q A EE RR R E R E EA R E +Q + LE+
Sbjct: 796 APEKQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEA----RLRESEQARALLER 851
Query: 2640 EREELQQK 2647
E EE +++
Sbjct: 852 EAEEARRQ 859
>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
[Homo sapiens]
Length = 985
Score = 585 bits (1507), Expect = e-166
Identities = 371/908 (40%), Positives = 550/908 (60%), Gaps = 59/908 (6%)
Query: 1749 VSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPIS 1808
+SR S + ++ S++ K +EK+K+KE KD + NGH F++I V G
Sbjct: 1 MSRIESLTRARIDRSRELASKTREKEKMKEA--------KDARYTNGHLFTTISVSGMTM 52
Query: 1809 CSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMR 1868
C C K T K+A C C+ +H C+++LA+C KVK KQ K +L ++T+ L +V +R
Sbjct: 53 CYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTA-LQSVSLR 111
Query: 1869 NKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWK 1928
+K + +ERP SA+ D + + +RR + S+SL+KSVS NI G NDE+ +
Sbjct: 112 SKTTI-RERPSSAIYPSDSFRQS-LLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRR 169
Query: 1929 FLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKF 1988
LS STDSLN ++ S ESL DE ++ +L+ DFE++ K A+SWS +DS F
Sbjct: 170 ILSQSTDSLNMRNRTL-SVESLIDE----EVIYSELMSDFEMDEKDFAADSWSLAVDSSF 224
Query: 1989 LKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDE 2048
L+Q KK+V+K+Q+VIYEL+QTE HHVRTLKIM+ ++ GM+ +L E +V+ LFPC+DE
Sbjct: 225 LQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDE 284
Query: 2049 LISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQH 2108
L IH++F ++LER++++L S +NF+I R+GD+L++QFSG +AE++ KTY +FC +H
Sbjct: 285 LSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRH 344
Query: 2109 NQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCT 2168
++++ +K+LYA+DKRFQ F++K +V++R G+ ECILLVTQRITKYP+L RILQ +
Sbjct: 345 SKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHS 404
Query: 2169 KDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAK 2228
E E++DL +L LVK+++ VD + EK RL EIY + D ++ + F +
Sbjct: 405 HGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGR 464
Query: 2229 EDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLK 2288
E+L R+KL+ DG + K A GR K+V +L+TD+LVFLQEKDQKYIF +LD K +V+SL+
Sbjct: 465 EELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSVVSLQ 523
Query: 2289 KLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIP 2348
LIVR++A++EKG+FLIS PEM EVH +S+++R++WI++IQ ++ T ED +
Sbjct: 524 NLIVRDIANQEKGMFLIS--AAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPL- 580
Query: 2349 SENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED-----CSP 2403
E E+E + R +K +L QKD+ ++ LL EK +F +M ED P
Sbjct: 581 IETEDEAYL-----RRIKMELQQKDRALVELLREKVGLFAEMTHFQA--EEDGGSGMALP 633
Query: 2404 THSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPV 2463
T PR LFRS + E+ +G L++ AI EVE L+ L+ G G L T P
Sbjct: 634 T-LPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGP-GVELLLTPREP--------- 682
Query: 2464 SLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLK-KGGNANLVFMLKRNS 2522
+LP ++ GG S + A+ GE + +L R +SDS + + GN L+
Sbjct: 683 ALPLEPDS-GGNTSPGVTAN--GEARTFNGSIELCRADSDSSQRDRNGN-----QLRSPQ 734
Query: 2523 EQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER--ALTRSLSRPSSLIEQ-EKQR 2579
E+ +Q +V+LY LL LQ V QQD+ +E + ER L R+ SR
Sbjct: 735 EEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPV 794
Query: 2580 SLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEK 2639
+ EKQ +LA LQ+Q A EE RR R E R E EA R E +Q + LE+
Sbjct: 795 APEKQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEA----RLRESEQARALLER 850
Query: 2640 EREELQQK 2647
E EE +++
Sbjct: 851 EAEEARRQ 858
>gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isooform 3
[Homo sapiens]
Length = 958
Score = 574 bits (1479), Expect = e-163
Identities = 361/869 (41%), Positives = 531/869 (61%), Gaps = 51/869 (5%)
Query: 1788 KDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKM 1847
KD + NGH F++I V G C C K T K+A C C+ +H C+++LA+C KVK
Sbjct: 5 KDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQ 64
Query: 1848 KQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSK 1907
KQ K +L ++T+ L +V +R+K + +ERP SA+ D + + +RR + S+SL+K
Sbjct: 65 KQQKAALLKNNTA-LQSVSLRSKTTI-RERPSSAIYPSDSFRQS-LLGSRRGRSSLSLAK 121
Query: 1908 SVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGD 1967
SVS NI G NDE+ + LS STDSLN ++ S ESL DE ++ +L+ D
Sbjct: 122 SVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTL-SVESLIDE----EVIYSELMSD 176
Query: 1968 FEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQG 2027
FE++ K A+SWS +DS FL+Q KK+V+K+Q+VIYEL+QTE HHVRTLKIM+ ++ G
Sbjct: 177 FEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTG 236
Query: 2028 MMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN 2087
M+ +L E +V+ LFPC+DEL IH++F ++LER++++L S +NF+I R+GD+L++
Sbjct: 237 MLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLIS 296
Query: 2088 QFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECI 2147
QFSG +AE++ KTY +FC +H++++ +K+LYA+DKRFQ F++K +V++R G+ ECI
Sbjct: 297 QFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECI 356
Query: 2148 LLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNE 2207
LLVTQRITKYP+L RILQ + E E++DL +L LVK+++ VD + EK RL E
Sbjct: 357 LLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQE 416
Query: 2208 IYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ 2267
IY + D ++ + F +E+L R+KL+ DG + K A GR K+V +L+TD+LVFLQ
Sbjct: 417 IYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQ 476
Query: 2268 EKDQKYIFASLDQKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNS 2327
EKDQKYIF +LD K +V+SL+ LIVR++A++EKG+FLIS PEM EVH +S+++R++
Sbjct: 477 EKDQKYIFPTLD-KPSVVSLQNLIVRDIANQEKGMFLIS--AAPPEMYEVHTASRDDRST 533
Query: 2328 WIQIIQDTINTLNRDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIF 2387
WI++IQ ++ T ED + E E+E + R +K +L QKD+ ++ LL EK +F
Sbjct: 534 WIRVIQQSVRTCPSREDFPL-IETEDEAYL-----RRIKMELQQKDRALVELLREKVGLF 587
Query: 2388 RDMAECSTPLPED-----CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGN 2442
+M ED PT PR LFRS + E+ +G L++ AI EVE L+ L+ G
Sbjct: 588 AEMTHFQA--EEDGGSGMALPT-LPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGP 644
Query: 2443 LGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTES 2502
G L T P +LP ++ GG S + A+ GE + +L R +S
Sbjct: 645 -GVELLLTPREP---------ALPLEPDS-GGNTSPGVTAN--GEARTFNGSIELCRADS 691
Query: 2503 DSGLK-KGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER- 2560
DS + + GN L+ E+ +Q +V+LY LL LQ V QQD+ +E + ER
Sbjct: 692 DSSQRDRNGN-----QLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERR 746
Query: 2561 -ALTRSLSRPSSLIEQ-EKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELRE 2618
L R+ SR + EKQ +LA LQ+Q A EE RR R E R E
Sbjct: 747 EKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEERATEAGS 806
Query: 2619 REALLAQREEEVQQGQQDLEKEREELQQK 2647
EA R E +Q + LE+E EE +++
Sbjct: 807 LEA----RLRESEQARALLEREAEEARRQ 831
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [Homo
sapiens]
Length = 927
Score = 189 bits (480), Expect = 3e-47
Identities = 127/406 (31%), Positives = 207/406 (50%), Gaps = 26/406 (6%)
Query: 1951 TDEGVGTDMNEGQLLGDFEIESKQLEAES---WSRIIDSKFLKQQKKDVVKRQEVIYELM 2007
TDEG T+ E G+ +LE E W ++ L K VKRQEVI EL+
Sbjct: 381 TDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELL 440
Query: 2008 QTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 2067
TE HVR L+++ ++ Q M L F + ++ +FP LDELI +HS F R+++R++ES
Sbjct: 441 VTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 500
Query: 2068 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 2127
+LI+ IGDVL+ +F G +K +FC + + ++ K KD RF A
Sbjct: 501 -------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCA 553
Query: 2128 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 2187
FV++ S RRL + + I QR+TKYP+L Q I Q T++ E+E + + ++
Sbjct: 554 FVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCRE 612
Query: 2188 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQM---FAKEDLKRKKLVRDGSVFL 2244
++ V+ V E +RL + + D S +R S M F D+ +KKLV +G +
Sbjct: 613 ILHHVNQAVRDMEDLLRLKDYQRRLD-LSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 671
Query: 2245 KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKST-----------VISLKKLIVR 2293
+ + EV +LL D+L+ LQ +D++ + S + T V+ L + R
Sbjct: 672 RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 731
Query: 2294 EVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2339
EVA + K +++ + ++ E+ A + ER +W +I +T +L
Sbjct: 732 EVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSL 777
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [Homo
sapiens]
Length = 879
Score = 189 bits (480), Expect = 3e-47
Identities = 127/406 (31%), Positives = 207/406 (50%), Gaps = 26/406 (6%)
Query: 1951 TDEGVGTDMNEGQLLGDFEIESKQLEAES---WSRIIDSKFLKQQKKDVVKRQEVIYELM 2007
TDEG T+ E G+ +LE E W ++ L K VKRQEVI EL+
Sbjct: 333 TDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELL 392
Query: 2008 QTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 2067
TE HVR L+++ ++ Q M L F + ++ +FP LDELI +HS F R+++R++ES
Sbjct: 393 VTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 452
Query: 2068 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 2127
+LI+ IGDVL+ +F G +K +FC + + ++ K KD RF A
Sbjct: 453 -------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCA 505
Query: 2128 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 2187
FV++ S RRL + + I QR+TKYP+L Q I Q T++ E+E + + ++
Sbjct: 506 FVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCRE 564
Query: 2188 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQM---FAKEDLKRKKLVRDGSVFL 2244
++ V+ V E +RL + + D S +R S M F D+ +KKLV +G +
Sbjct: 565 ILHHVNQAVRDMEDLLRLKDYQRRLD-LSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 623
Query: 2245 KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKST-----------VISLKKLIVR 2293
+ + EV +LL D+L+ LQ +D++ + S + T V+ L + R
Sbjct: 624 RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 683
Query: 2294 EVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2339
EVA + K +++ + ++ E+ A + ER +W +I +T +L
Sbjct: 684 EVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSL 729
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [Homo
sapiens]
Length = 912
Score = 189 bits (480), Expect = 3e-47
Identities = 127/406 (31%), Positives = 207/406 (50%), Gaps = 26/406 (6%)
Query: 1951 TDEGVGTDMNEGQLLGDFEIESKQLEAES---WSRIIDSKFLKQQKKDVVKRQEVIYELM 2007
TDEG T+ E G+ +LE E W ++ L K VKRQEVI EL+
Sbjct: 366 TDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELL 425
Query: 2008 QTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 2067
TE HVR L+++ ++ Q M L F + ++ +FP LDELI +HS F R+++R++ES
Sbjct: 426 VTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 485
Query: 2068 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 2127
+LI+ IGDVL+ +F G +K +FC + + ++ K KD RF A
Sbjct: 486 -------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCA 538
Query: 2128 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 2187
FV++ S RRL + + I QR+TKYP+L Q I Q T++ E+E + + ++
Sbjct: 539 FVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCRE 597
Query: 2188 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQM---FAKEDLKRKKLVRDGSVFL 2244
++ V+ V E +RL + + D S +R S M F D+ +KKLV +G +
Sbjct: 598 ILHHVNQAVRDMEDLLRLKDYQRRLD-LSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 656
Query: 2245 KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKST-----------VISLKKLIVR 2293
+ + EV +LL D+L+ LQ +D++ + S + T V+ L + R
Sbjct: 657 RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 716
Query: 2294 EVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2339
EVA + K +++ + ++ E+ A + ER +W +I +T +L
Sbjct: 717 EVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSL 762
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 178 bits (451), Expect = 8e-44
Identities = 183/805 (22%), Positives = 359/805 (44%), Gaps = 111/805 (13%)
Query: 1763 SKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPV----VGPISCSQCMKPFTN 1818
+KKS +KEKD +++K+++ K K + + IP+ V P + ++ F N
Sbjct: 555 TKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFEN 614
Query: 1819 KDAYTCAN------CSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPS 1872
Y + + ES +S +++++ + + SL+ + + R++ +
Sbjct: 615 NQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSE-SLKGREE------MKRSRKA 667
Query: 1873 QPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH 1932
+ R RS V + D A A R Q + S + S+S +++ + T K
Sbjct: 668 ENVPRSRSDVDM-DAAAE----ATRLHQSASSSTSSLSTRSL----ENPTPPFTPKMGRR 718
Query: 1933 STDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQ 1992
S +S + T++L + D+ + L D E E +A++W + +
Sbjct: 719 SIES----PSLGFCTDTLLPHLLEDDLGQ---LSDLEPEP---DAQNWQHTVGKDVVAGL 768
Query: 1993 KKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISI 2052
+ + RQEVI EL TE H+RTL+++ ++ Q M + L ++ + +LFP L ELI I
Sbjct: 769 TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 828
Query: 2053 HSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSV 2112
H+ + + + + ++E + IK I D+++ +F G E L++ +FC + ++
Sbjct: 829 HNSWCEAMKKLREEGPI--------IKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL 880
Query: 2113 NYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNE 2172
K K+ RFQ F+++ S RRL + + I+ QR+TKYP+L + I++ T+
Sbjct: 881 ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT 940
Query: 2173 VEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKS--GQMFAKED 2230
E E L ++ ++++ V+ V E + RL + D+ ++ R + F D
Sbjct: 941 SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD 1000
Query: 2231 LKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIF--------ASLDQKS 2282
L +K++ +G + + + + ++ +LL D+LV LQ++D+K + S D K
Sbjct: 1001 LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ 1060
Query: 2283 T---VISLKKLIVREVAHEEKGLFLI-SMGMTDPEMVEVHASSKEERNSWIQIIQDTINT 2338
T V+ L +++R VA +++ F+I + + P++ E+ A + ++N+W++++++ +
Sbjct: 1061 TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN 1120
Query: 2339 LNR-------------------------------DEDEGIPSENEEEKKMLDTRARELKE 2367
R D+ + E E E+ T +++ +
Sbjct: 1121 ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ 1180
Query: 2368 QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMK- 2426
HQ +LL E+E + P P + + R+ A G M+
Sbjct: 1181 GKHQ----VLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEG 1236
Query: 2427 ---SAINEVEILQGLVSGNL--GGTLGPTVSSPIEQDVVGPVSL------------PRRA 2469
SA+ +VE L+ L+ +L G T+ + E D+ S+ P +A
Sbjct: 1237 LADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQA 1296
Query: 2470 ETFGGFDSHQMNASKGGEKEEGDDG 2494
G D+ Q+ +G E+ D G
Sbjct: 1297 PPGGEGDNTQLAGLEGERPEQEDMG 1321
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 178 bits (451), Expect = 8e-44
Identities = 183/805 (22%), Positives = 359/805 (44%), Gaps = 111/805 (13%)
Query: 1763 SKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPV----VGPISCSQCMKPFTN 1818
+KKS +KEKD +++K+++ K K + + IP+ V P + ++ F N
Sbjct: 515 TKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFEN 574
Query: 1819 KDAYTCAN------CSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPS 1872
Y + + ES +S +++++ + + SL+ + + R++ +
Sbjct: 575 NQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSE-SLKGREE------MKRSRKA 627
Query: 1873 QPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH 1932
+ R RS V + D A A R Q + S + S+S +++ + T K
Sbjct: 628 ENVPRSRSDVDM-DAAAE----ATRLHQSASSSTSSLSTRSL----ENPTPPFTPKMGRR 678
Query: 1933 STDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQ 1992
S +S + T++L + D+ + L D E E +A++W + +
Sbjct: 679 SIES----PSLGFCTDTLLPHLLEDDLGQ---LSDLEPEP---DAQNWQHTVGKDVVAGL 728
Query: 1993 KKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISI 2052
+ + RQEVI EL TE H+RTL+++ ++ Q M + L ++ + +LFP L ELI I
Sbjct: 729 TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 788
Query: 2053 HSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSV 2112
H+ + + + + ++E + IK I D+++ +F G E L++ +FC + ++
Sbjct: 789 HNSWCEAMKKLREEGPI--------IKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL 840
Query: 2113 NYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNE 2172
K K+ RFQ F+++ S RRL + + I+ QR+TKYP+L + I++ T+
Sbjct: 841 ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT 900
Query: 2173 VEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKS--GQMFAKED 2230
E E L ++ ++++ V+ V E + RL + D+ ++ R + F D
Sbjct: 901 SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD 960
Query: 2231 LKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIF--------ASLDQKS 2282
L +K++ +G + + + + ++ +LL D+LV LQ++D+K + S D K
Sbjct: 961 LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ 1020
Query: 2283 T---VISLKKLIVREVAHEEKGLFLI-SMGMTDPEMVEVHASSKEERNSWIQIIQDTINT 2338
T V+ L +++R VA +++ F+I + + P++ E+ A + ++N+W++++++ +
Sbjct: 1021 TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN 1080
Query: 2339 LNR-------------------------------DEDEGIPSENEEEKKMLDTRARELKE 2367
R D+ + E E E+ T +++ +
Sbjct: 1081 ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ 1140
Query: 2368 QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMK- 2426
HQ +LL E+E + P P + + R+ A G M+
Sbjct: 1141 GKHQ----VLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEG 1196
Query: 2427 ---SAINEVEILQGLVSGNL--GGTLGPTVSSPIEQDVVGPVSL------------PRRA 2469
SA+ +VE L+ L+ +L G T+ + E D+ S+ P +A
Sbjct: 1197 LADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQA 1256
Query: 2470 ETFGGFDSHQMNASKGGEKEEGDDG 2494
G D+ Q+ +G E+ D G
Sbjct: 1257 PPGGEGDNTQLAGLEGERPEQEDMG 1281
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 169 bits (427), Expect = 5e-41
Identities = 124/463 (26%), Positives = 221/463 (47%), Gaps = 42/463 (9%)
Query: 1937 LNKISKVNESTESLTDEGVGTDMN--EGQLLGDFEIESKQLEAE------SWSRIIDSKF 1988
L+++ + E +T+ G + G+ + E +Q E + +W +++ +
Sbjct: 718 LDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREV 777
Query: 1989 LKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDE 2048
L K +KRQEVI EL TE HVRTLK++ V+ Q + + + + K+F L++
Sbjct: 778 LLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLED 837
Query: 2049 LISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQH 2108
++ +H +++ V K + +I +IG+ L+ FSG E+LK FC
Sbjct: 838 ILQLHIGLNEQM------KAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQ 891
Query: 2109 NQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCT 2168
++ K KD RFQ FV+ S+ + RRL + + I QR+TKYP+L I + T
Sbjct: 892 PFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYT 951
Query: 2169 KDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKS--IMRMKSGQMF 2226
+ E+E + ++ + ++ V+ V E K RL + + D+ S + + +
Sbjct: 952 -EWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEEL 1010
Query: 2227 AKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKD--------QKYIFASL 2278
DL ++K++ +G + K + ++ +LL DILV LQ++D K + ++
Sbjct: 1011 RNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTA 1070
Query: 2279 DQKST---VISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDT 2335
D K T VI L ++VR+VA + K LF+ISM ++ E+ A + E+ W +I
Sbjct: 1071 DSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRM 1130
Query: 2336 INTLNRDEDEGIP--------SENEEEKKMLDTRARELKEQLH 2370
++ + IP +N+EE +LKE+ H
Sbjct: 1131 AASVKEQSTKPIPLPQSTPGEGDNDEED------PSKLKEEQH 1167
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 [Homo
sapiens]
Length = 532
Score = 81.6 bits (200), Expect = 1e-14
Identities = 58/268 (21%), Positives = 126/268 (47%), Gaps = 16/268 (5%)
Query: 1972 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2031
+K+ +++ WS D + +KRQE I+EL Q E + LK+ Y M+
Sbjct: 102 TKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKL 161
Query: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2091
+ +Q + ++F LD LI +H + ++ + +K D S ++ +G +LV
Sbjct: 162 SIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWLP- 212
Query: 2092 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2151
+Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 213 -----CLSSYDSYC-SNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPR 266
Query: 2152 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYE-KKVRLNEIYT 2210
R+ KYP+L + IL+ T ++ +Q+ L +++++++ ++ +++K E + + +Y
Sbjct: 267 SRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYL 326
Query: 2211 KTDSKSIMRMKSGQMFAKEDLKRKKLVR 2238
+ K + S + +LK + V+
Sbjct: 327 EEGQKDSLIDSSRVLCCHGELKNNRGVK 354
>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 [Homo
sapiens]
Length = 558
Score = 81.6 bits (200), Expect = 1e-14
Identities = 58/268 (21%), Positives = 126/268 (47%), Gaps = 16/268 (5%)
Query: 1972 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2031
+K+ +++ WS D + +KRQE I+EL Q E + LK+ Y M+
Sbjct: 128 TKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKL 187
Query: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2091
+ +Q + ++F LD LI +H + ++ + +K D S ++ +G +LV
Sbjct: 188 SIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWLP- 238
Query: 2092 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2151
+Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 239 -----CLSSYDSYC-SNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPR 292
Query: 2152 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYE-KKVRLNEIYT 2210
R+ KYP+L + IL+ T ++ +Q+ L +++++++ ++ +++K E + + +Y
Sbjct: 293 SRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYL 352
Query: 2211 KTDSKSIMRMKSGQMFAKEDLKRKKLVR 2238
+ K + S + +LK + V+
Sbjct: 353 EEGQKDSLIDSSRVLCCHGELKNNRGVK 380
>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
sapiens]
Length = 526
Score = 81.6 bits (200), Expect = 1e-14
Identities = 58/268 (21%), Positives = 126/268 (47%), Gaps = 16/268 (5%)
Query: 1972 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2031
+K+ +++ WS D + +KRQE I+EL Q E + LK+ Y M+
Sbjct: 96 TKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKL 155
Query: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2091
+ +Q + ++F LD LI +H + ++ + +K D S ++ +G +LV
Sbjct: 156 SIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWLP- 206
Query: 2092 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2151
+Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 207 -----CLSSYDSYC-SNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPR 260
Query: 2152 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYE-KKVRLNEIYT 2210
R+ KYP+L + IL+ T ++ +Q+ L +++++++ ++ +++K E + + +Y
Sbjct: 261 SRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYL 320
Query: 2211 KTDSKSIMRMKSGQMFAKEDLKRKKLVR 2238
+ K + S + +LK + V+
Sbjct: 321 EEGQKDSLIDSSRVLCCHGELKNNRGVK 348
>gi|38373682 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 78.6 bits (192), Expect = 8e-14
Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)
Query: 1978 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 2031
+SW +ID K ++Q +QE ++EL+ TE ++R L+++ ++ ++ +
Sbjct: 318 DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 373
Query: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 2090
LL E + E+LF + E+ +H + + ++ +++K+ + + + GD L +
Sbjct: 374 LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 428
Query: 2091 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 2150
G L K Y ++C + + Y + L + F+A++ +RL + + +
Sbjct: 429 GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 484
Query: 2151 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 2210
QR+TKYP+L + +L+ T++ ++ +A + V+ I V++ + +++ RL + +
Sbjct: 485 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 543
Query: 2211 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 2254
+ D+ ++ S ++ F DL + ++L+ +GS+ +K +V
Sbjct: 544 RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 603
Query: 2255 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 2312
L TD+L+ + + +++ VI L+ + V E + G FL+
Sbjct: 604 YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 656
Query: 2313 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 2351
V + AS + W+ I Q + +L +EDE E
Sbjct: 657 SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 716
Query: 2352 EEEKK 2356
EEE++
Sbjct: 717 EEEEE 721
>gi|111154084 pleckstrin homology domain containing family G member 5
isoform b [Homo sapiens]
Length = 1083
Score = 78.6 bits (192), Expect = 8e-14
Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)
Query: 1978 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 2031
+SW +ID K ++Q +QE ++EL+ TE ++R L+++ ++ ++ +
Sbjct: 395 DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 450
Query: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 2090
LL E + E+LF + E+ +H + + ++ +++K+ + + + GD L +
Sbjct: 451 LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 505
Query: 2091 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 2150
G L K Y ++C + + Y + L + F+A++ +RL + + +
Sbjct: 506 GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 561
Query: 2151 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 2210
QR+TKYP+L + +L+ T++ ++ +A + V+ I V++ + +++ RL + +
Sbjct: 562 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 620
Query: 2211 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 2254
+ D+ ++ S ++ F DL + ++L+ +GS+ +K +V
Sbjct: 621 RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 680
Query: 2255 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 2312
L TD+L+ + + +++ VI L+ + V E + G FL+
Sbjct: 681 YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 733
Query: 2313 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 2351
V + AS + W+ I Q + +L +EDE E
Sbjct: 734 SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 793
Query: 2352 EEEKK 2356
EEE++
Sbjct: 794 EEEEE 798
>gi|111154088 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 78.6 bits (192), Expect = 8e-14
Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)
Query: 1978 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 2031
+SW +ID K ++Q +QE ++EL+ TE ++R L+++ ++ ++ +
Sbjct: 318 DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 373
Query: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 2090
LL E + E+LF + E+ +H + + ++ +++K+ + + + GD L +
Sbjct: 374 LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 428
Query: 2091 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 2150
G L K Y ++C + + Y + L + F+A++ +RL + + +
Sbjct: 429 GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 484
Query: 2151 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 2210
QR+TKYP+L + +L+ T++ ++ +A + V+ I V++ + +++ RL + +
Sbjct: 485 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 543
Query: 2211 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 2254
+ D+ ++ S ++ F DL + ++L+ +GS+ +K +V
Sbjct: 544 RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 603
Query: 2255 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 2312
L TD+L+ + + +++ VI L+ + V E + G FL+
Sbjct: 604 YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 656
Query: 2313 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 2351
V + AS + W+ I Q + +L +EDE E
Sbjct: 657 SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 716
Query: 2352 EEEKK 2356
EEE++
Sbjct: 717 EEEEE 721
>gi|111154080 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 78.6 bits (192), Expect = 8e-14
Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)
Query: 1978 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 2031
+SW +ID K ++Q +QE ++EL+ TE ++R L+++ ++ ++ +
Sbjct: 318 DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 373
Query: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 2090
LL E + E+LF + E+ +H + + ++ +++K+ + + + GD L +
Sbjct: 374 LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 428
Query: 2091 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 2150
G L K Y ++C + + Y + L + F+A++ +RL + + +
Sbjct: 429 GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 484
Query: 2151 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 2210
QR+TKYP+L + +L+ T++ ++ +A + V+ I V++ + +++ RL + +
Sbjct: 485 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 543
Query: 2211 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 2254
+ D+ ++ S ++ F DL + ++L+ +GS+ +K +V
Sbjct: 544 RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 603
Query: 2255 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 2312
L TD+L+ + + +++ VI L+ + V E + G FL+
Sbjct: 604 YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 656
Query: 2313 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 2351
V + AS + W+ I Q + +L +EDE E
Sbjct: 657 SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 716
Query: 2352 EEEKK 2356
EEE++
Sbjct: 717 EEEEE 721
>gi|111154078 pleckstrin homology domain containing family G member 5
isoform c [Homo sapiens]
Length = 1062
Score = 78.6 bits (192), Expect = 8e-14
Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)
Query: 1978 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 2031
+SW +ID K ++Q +QE ++EL+ TE ++R L+++ ++ ++ +
Sbjct: 374 DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 429
Query: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 2090
LL E + E+LF + E+ +H + + ++ +++K+ + + + GD L +
Sbjct: 430 LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 484
Query: 2091 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 2150
G L K Y ++C + + Y + L + F+A++ +RL + + +
Sbjct: 485 GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 540
Query: 2151 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 2210
QR+TKYP+L + +L+ T++ ++ +A + V+ I V++ + +++ RL + +
Sbjct: 541 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 599
Query: 2211 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 2254
+ D+ ++ S ++ F DL + ++L+ +GS+ +K +V
Sbjct: 600 RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 659
Query: 2255 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 2312
L TD+L+ + + +++ VI L+ + V E + G FL+
Sbjct: 660 YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 712
Query: 2313 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 2351
V + AS + W+ I Q + +L +EDE E
Sbjct: 713 SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 772
Query: 2352 EEEKK 2356
EEE++
Sbjct: 773 EEEEE 777
>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 [Homo
sapiens]
Length = 596
Score = 77.8 bits (190), Expect = 1e-13
Identities = 100/480 (20%), Positives = 201/480 (41%), Gaps = 67/480 (13%)
Query: 1972 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2031
+K+ + WS ++D + ++RQE IYE+ + E + LK+ Y M+
Sbjct: 148 AKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKL 207
Query: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2091
+ ++ + +F LD I +H RI E K + +++IG +LV+
Sbjct: 208 SIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATK--------PDGTVEQIGHILVSWLPR 259
Query: 2092 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2151
NA Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 260 LNA------YRGYC-SNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPR 312
Query: 2152 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTK 2211
R+ KYP+L + IL+ T + + L ++ +++ V+ ++ K E + ++++
Sbjct: 313 SRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYL 372
Query: 2212 TDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ--EK 2269
+ + R+++ K L+ G L++ +G ++ L DILV + +
Sbjct: 373 DEKQRDPRIEAS----------KVLLCHGE--LRSKSGH--KLYIFLFQDILVLTRPVTR 418
Query: 2270 DQKYIFASLDQKSTVISLKKLIVREV---------------AHEEKGLFLISMGMTDPEM 2314
++++ + Q I +++L++ ++ ++ EK + + DP
Sbjct: 419 NERHSYQVYRQP---IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSP 475
Query: 2315 VEVH---ASSKEERNSWIQIIQDTI----NTLNRDEDEGIPSENEEEKKMLDTRARELKE 2367
+ H A+ + W I+ I + + E +G+P E EE + AR+L
Sbjct: 476 AQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLP-ELHEECEGNHPSARKLTA 534
Query: 2368 QLHQKDQKILLLLEEKEMIFR-----DMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGG 2422
Q + +E E +R MAE S L TH + R ++AL GG
Sbjct: 535 QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSL-----KTHQTQPGIRRARDKALSGG 589
>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [Homo
sapiens]
Length = 542
Score = 77.8 bits (190), Expect = 1e-13
Identities = 100/480 (20%), Positives = 201/480 (41%), Gaps = 67/480 (13%)
Query: 1972 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2031
+K+ + WS ++D + ++RQE IYE+ + E + LK+ Y M+
Sbjct: 94 AKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKL 153
Query: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2091
+ ++ + +F LD I +H RI E K + +++IG +LV+
Sbjct: 154 SIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATK--------PDGTVEQIGHILVSWLPR 205
Query: 2092 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2151
NA Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 206 LNA------YRGYC-SNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPR 258
Query: 2152 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTK 2211
R+ KYP+L + IL+ T + + L ++ +++ V+ ++ K E + ++++
Sbjct: 259 SRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYL 318
Query: 2212 TDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ--EK 2269
+ + R+++ K L+ G L++ +G ++ L DILV + +
Sbjct: 319 DEKQRDPRIEAS----------KVLLCHGE--LRSKSGH--KLYIFLFQDILVLTRPVTR 364
Query: 2270 DQKYIFASLDQKSTVISLKKLIVREV---------------AHEEKGLFLISMGMTDPEM 2314
++++ + Q I +++L++ ++ ++ EK + + DP
Sbjct: 365 NERHSYQVYRQP---IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSP 421
Query: 2315 VEVH---ASSKEERNSWIQIIQDTI----NTLNRDEDEGIPSENEEEKKMLDTRARELKE 2367
+ H A+ + W I+ I + + E +G+P E EE + AR+L
Sbjct: 422 AQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLP-ELHEECEGNHPSARKLTA 480
Query: 2368 QLHQKDQKILLLLEEKEMIFR-----DMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGG 2422
Q + +E E +R MAE S L TH + R ++AL GG
Sbjct: 481 QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSL-----KTHQTQPGIRRARDKALSGG 535
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 76.6 bits (187), Expect = 3e-13
Identities = 99/460 (21%), Positives = 198/460 (43%), Gaps = 57/460 (12%)
Query: 1900 QQSVSLSKSVSIQNI-----TGVGNDENMSNTWKFLSHSTDSLNKISKVNESTESLTDEG 1954
+++ +LS SIQ T + N E S +TDS + N S S G
Sbjct: 105 EKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDG----NASDSSYRTPG 160
Query: 1955 VGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQ----QKKDVVKRQEVIYELMQTE 2010
+G + + E E+K E E+ ++ + L Q ++ + K ++ EL+ TE
Sbjct: 161 IGPVLPLEER--GAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTE 218
Query: 2011 FHHVRTLKIMSGVYSQGMMADL---LFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 2067
+V L ++ V+ ++ + F +MV K+F + + + HS+F LE++ +
Sbjct: 219 RAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQE 278
Query: 2068 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 2127
RIGD+L + K YG++ + ++ K++ + +F++
Sbjct: 279 WETTP-------RIGDIL------QKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKS 325
Query: 2128 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 2187
V++ + L + +L QRI +Y +L + L+ + ++ D +SL ++
Sbjct: 326 VVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIIST 385
Query: 2188 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNA 2247
+S + E +L EIY + + S + L+++G + LK A
Sbjct: 386 AASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNE-----------LIKEGQI-LKLA 433
Query: 2248 AGRL--KEVQAVLLTDILVFLQEKDQKYIFASLDQKSTV---ISLKKLIVREVAHEE-KG 2301
A +E L ++L++ K F+ + K TV + + + + E +EE
Sbjct: 434 ARNTSAQERYLFLFNNMLLYCVPK-----FSLVGSKFTVRTRVGIDGMKIVETQNEEYPH 488
Query: 2302 LFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNR 2341
F +S +E+ ASS +++ WI+ +Q+TI+ ++
Sbjct: 489 TFQVS---GKERTLELQASSAQDKEEWIKALQETIDAFHQ 525
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 75.9 bits (185), Expect = 5e-13
Identities = 78/347 (22%), Positives = 145/347 (41%), Gaps = 27/347 (7%)
Query: 1998 KRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFF 2057
KRQ I+EL+ TE ++V L++++ ++ + +M L ++ V +F ELI + +
Sbjct: 1237 KRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLL 1296
Query: 2058 QRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKD 2117
+ + RKK S + +K IGD+L Q + Y +FC + +
Sbjct: 1297 KALRVRKK-----MSGEKMPVKMIGDILSAQLPH------MQPYIRFCSRQLNGAALIQQ 1345
Query: 2118 LYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQED 2177
+ F+ FVK+ + + + IL QR+T+YP++ + IL+ T +N +
Sbjct: 1346 KTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSH 1405
Query: 2178 LAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLV 2237
L +L +++ V+ V E RL I + + L +K +
Sbjct: 1406 LKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNS-VTNCLGPRKFL 1464
Query: 2238 RDGSVFLKNAAGRLKEVQAVLLTDILVFLQ------EKDQKYIF---ASLDQK--STVIS 2286
G ++ A KE+ L D L+ Q +F ++L K T I
Sbjct: 1465 HSGKLY---KAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPIF 1521
Query: 2287 LKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQ 2333
L +++V+ + + D + + A S ER +W+Q I+
Sbjct: 1522 LNEVLVKLPTDPSGDEPIFHISHID-RVYTLRAESINERTAWVQKIK 1567
Score = 60.8 bits (146), Expect = 2e-08
Identities = 43/147 (29%), Positives = 87/147 (59%), Gaps = 12/147 (8%)
Query: 2544 LQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKR 2603
L ++ +ED++ L ++ + E+ LEK+RQ L Q+++ + L +
Sbjct: 329 LPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLE-LEKRRQALLEQQRKEQERLAQLE 387
Query: 2604 RREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQK 2663
R E+E + RER+ +ER+ L + E+++++ Q++LE++REE ++K ++ER AA++
Sbjct: 388 RAEQERKERERQEQERKRQL-ELEKQLEK-QRELERQREEERRK------EIERREAAKR 439
Query: 2664 QLEREQE---QLRREAERLSQRQTERD 2687
+LER+++ + R E L+QR E++
Sbjct: 440 ELERQRQLEWERNRRQELLNQRNKEQE 466
Score = 53.9 bits (128), Expect = 2e-06
Identities = 52/178 (29%), Positives = 87/178 (48%), Gaps = 23/178 (12%)
Query: 2534 ELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQK 2593
EL Q ++ QQ E ++L ERA R EQE++R LE ++Q L+K
Sbjct: 364 ELEKRRQALLEQQRK--EQERLAQLERAEQERKERERQ--EQERKRQLELEKQ----LEK 415
Query: 2594 QQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDL----EKEREE---LQQ 2646
Q+ LE +R ER E RE +RE ++ E + +Q+L KE+E+ L+
Sbjct: 416 QRE--LERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKA 473
Query: 2647 KKGTYQYDLERLRAAQKQLEREQEQLR------REAERLSQRQTERDLCQVSHPHTKL 2698
KK T +++LE L + QLE + + +R R+ + + E + +++H +L
Sbjct: 474 KKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQL 531
Score = 48.5 bits (114), Expect = 9e-05
Identities = 46/237 (19%), Positives = 109/237 (45%), Gaps = 18/237 (7%)
Query: 2495 QDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQK 2554
Q++ T L+ +L L+ + + + + + L L+ V QQ+S D
Sbjct: 508 QEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQV--QQNSLHRDSL 565
Query: 2555 LVLSERALTRSLSRP---SSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRR--REREW 2609
+ L + L+R L E EK+ + Q D+ N Q ++ + + K++ +++
Sbjct: 566 VTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSM 625
Query: 2610 EARERELREREALLAQREEEVQQGQQDL-EKEREELQQKKGTYQYDLERLRAAQKQLERE 2668
EA + +E+E + + E++ ++ Q+ E++++ L+ + ++ R +++L+RE
Sbjct: 626 EAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKRE 685
Query: 2669 QEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSIAKSGSL 2725
+ +++ E +++ + L ++ H H + P +P + S A+ G L
Sbjct: 686 ESVKKKDGEEKGKQEAQDKLGRLFHQHQE----------PAKPAVQAPWSTAEKGPL 732
Score = 35.8 bits (81), Expect = 0.61
Identities = 30/137 (21%), Positives = 67/137 (48%), Gaps = 9/137 (6%)
Query: 2544 LQQDSYIEDQKLVLSERALTRSLS---RPSSLIEQEKQRSLE---KQRQDLANLQKQQAQ 2597
L+ + +E Q+ + +R R R ++ E E+QR LE +RQ+L N + ++ +
Sbjct: 407 LELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQE 466
Query: 2598 YLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLER 2657
+ + +++ E L +++ Q E ++Q + L +R+E++ + + +
Sbjct: 467 DIVVLKAKKKTLEFELEALNDKK---HQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAE 523
Query: 2658 LRAAQKQLEREQEQLRR 2674
+ Q+QL+ Q+ L R
Sbjct: 524 ITHLQQQLQESQQMLGR 540
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 74.7 bits (182), Expect = 1e-12
Identities = 79/379 (20%), Positives = 155/379 (40%), Gaps = 35/379 (9%)
Query: 1998 KRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFF 2057
KRQ I+EL+QTE ++ L+++ V+ + M + + +F ELI +++
Sbjct: 1182 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1241
Query: 2058 QRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKD 2117
+ + RKK + ++ IGD+L + S A Y +FC +
Sbjct: 1242 KALRVRKKTG-----GEKMPVQMIGDILAAELSHMQA------YIRFCSCQLNGAALLQQ 1290
Query: 2118 LYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQED 2177
+D F+ F+KK S + + + +L QRIT+YP+L + IL+ T ++ +
Sbjct: 1291 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1350
Query: 2178 LAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLV 2237
L +L +++ V+ V E RL I + + L +KL+
Sbjct: 1351 LKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLT-NCLGPRKLL 1409
Query: 2238 RDGSVFLKNAAGRLKEVQAVLLTDILV-------FLQEKDQKYIFAS-----LDQKSTVI 2285
G ++ + KE+ L D L+ F + +F+S T I
Sbjct: 1410 HSGKLYKTKSN---KELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPI 1466
Query: 2286 SLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDE 2345
L +++V+ + + D + + + ER +W+Q I+ ++
Sbjct: 1467 FLNEVLVKLPTDPSSDEPVFHISHID-RVYTLRTDNINERTAWVQKIKAA-------SEQ 1518
Query: 2346 GIPSENEEEKKMLDTRARE 2364
I +E ++ +K R+++
Sbjct: 1519 YIDTEKKKREKAYQARSQK 1537
Score = 62.8 bits (151), Expect = 5e-09
Identities = 40/111 (36%), Positives = 72/111 (64%), Gaps = 13/111 (11%)
Query: 2581 LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE 2640
LEK+RQ L Q+++A+ + ++ + EWE ++REL+E+E E+ + Q++LE++
Sbjct: 378 LEKRRQALMEQQQREAE--RKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQ 435
Query: 2641 REELQQKKGTYQYDLERLRAAQKQLER----EQEQLRREAERLSQRQTERD 2687
REE ++K D+ER AA+++LER E E++RR+ E L+Q+ E++
Sbjct: 436 REEERRK------DIERREAAKQELERQRRLEWERIRRQ-ELLNQKNREQE 479
Score = 51.2 bits (121), Expect = 1e-05
Identities = 39/148 (26%), Positives = 76/148 (51%), Gaps = 19/148 (12%)
Query: 2551 EDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWE 2610
ED++ ER R +L+EQ+++ + K +++ +++Q + E++ +++ E E
Sbjct: 364 EDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELE 423
Query: 2611 ARERELREREALLAQREEEVQQ-------GQQDLEKER---------EELQQKKGTYQYD 2654
R + RE E QREEE ++ +Q+LE++R +EL +K Q +
Sbjct: 424 KRLEKQRELER---QREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 2655 LERLRAAQKQLEREQEQLRREAERLSQR 2682
+ RL + +K L E E L + +++S R
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGR 508
Score = 48.1 bits (113), Expect = 1e-04
Identities = 32/102 (31%), Positives = 60/102 (58%), Gaps = 8/102 (7%)
Query: 2592 QKQQAQYLEEKRRREREWEARERELREREALLAQREEEV----QQGQQDLEKEREELQQK 2647
QK+ E+KR+ E E E R R+AL+ Q++ E Q+ +++ E+++ ELQ++
Sbjct: 356 QKKLPVTFEDKRKANYERGNMELEKR-RQALMEQQQREAERKAQKEKEEWERKQRELQEQ 414
Query: 2648 KGTYQYDLERLRAAQKQLEREQEQLRR---EAERLSQRQTER 2686
+ Q +LE+ Q++LER++E+ RR E ++++ ER
Sbjct: 415 EWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELER 456
Score = 44.7 bits (104), Expect = 0.001
Identities = 48/226 (21%), Positives = 100/226 (44%), Gaps = 42/226 (18%)
Query: 2503 DSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERAL 2562
D LKK + +L + + + + L + L Q ++ Y+ +K +L+ER
Sbjct: 511 DVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLI----YLVPEKQLLNERIK 566
Query: 2563 TRSLSR-PSSLIEQEKQRSLEKQ------RQDLANLQKQQAQYLEE-------------- 2601
S P S + ++SLEK+ ++ L L+K+ A L E
Sbjct: 567 NMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRET 626
Query: 2602 --------------KRRREREWEARERELREREALLAQREEEVQQGQQDLEKE--REELQ 2645
KR + +E E + EL +++ L + + +QG+++L KE R+E +
Sbjct: 627 YNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE 686
Query: 2646 QKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQV 2691
+K+ Q + + + +++ + E++Q R++ + L + +R+ V
Sbjct: 687 EKQKRLQEEKTQEKIQEEERKAEEKQ-RKDKDTLKAEEKKRETASV 731
Score = 42.4 bits (98), Expect = 0.007
Identities = 54/254 (21%), Positives = 116/254 (45%), Gaps = 21/254 (8%)
Query: 2576 EKQRSLEKQRQD--LANLQKQQAQYLEEKRRREREWE-ARERELREREALLAQREEEVQQ 2632
EKQR LE+QR++ ++++++A E +R+R EWE R +EL ++ + +
Sbjct: 427 EKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNS 486
Query: 2633 GQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREA--ERLSQRQTERDLCQ 2690
+++L E E L K L+ +R ++ + E E L ++ E + +Q +++L +
Sbjct: 487 KKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQE 546
Query: 2691 VSH------PHTKLM--RIPS--FFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISR 2740
+ P +L+ RI + F +P+ S S+ SL+ E + +
Sbjct: 547 YQNKLIYLVPEKQLLNERIKNMQFSNTPD-----SGVSLLHKKSLEKEELCQRLKEQLDA 601
Query: 2741 THKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQP 2800
K+ + S N+ E + A +L+ + + K K+ ++K+ + + +
Sbjct: 602 LEKETAS-KLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK 660
Query: 2801 GDGPASEVSAEGEE 2814
+ A+ + +G+E
Sbjct: 661 LEDEAARKAKQGKE 674
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 74.7 bits (182), Expect = 1e-12
Identities = 79/379 (20%), Positives = 155/379 (40%), Gaps = 35/379 (9%)
Query: 1998 KRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFF 2057
KRQ I+EL+QTE ++ L+++ V+ + M + + +F ELI +++
Sbjct: 1209 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1268
Query: 2058 QRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKD 2117
+ + RKK + ++ IGD+L + S A Y +FC +
Sbjct: 1269 KALRVRKKTG-----GEKMPVQMIGDILAAELSHMQA------YIRFCSCQLNGAALLQQ 1317
Query: 2118 LYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQED 2177
+D F+ F+KK S + + + +L QRIT+YP+L + IL+ T ++ +
Sbjct: 1318 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1377
Query: 2178 LAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLV 2237
L +L +++ V+ V E RL I + + L +KL+
Sbjct: 1378 LKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLT-NCLGPRKLL 1436
Query: 2238 RDGSVFLKNAAGRLKEVQAVLLTDILV-------FLQEKDQKYIFAS-----LDQKSTVI 2285
G ++ + KE+ L D L+ F + +F+S T I
Sbjct: 1437 HSGKLYKTKSN---KELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPI 1493
Query: 2286 SLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDE 2345
L +++V+ + + D + + + ER +W+Q I+ ++
Sbjct: 1494 FLNEVLVKLPTDPSSDEPVFHISHID-RVYTLRTDNINERTAWVQKIKAA-------SEQ 1545
Query: 2346 GIPSENEEEKKMLDTRARE 2364
I +E ++ +K R+++
Sbjct: 1546 YIDTEKKKREKAYQARSQK 1564
Score = 62.8 bits (151), Expect = 5e-09
Identities = 41/111 (36%), Positives = 71/111 (63%), Gaps = 13/111 (11%)
Query: 2581 LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE 2640
LEK+RQ L Q+++A+ +K + E WE ++REL+E+E E+ + Q++LE++
Sbjct: 378 LEKRRQALMEQQQREAERKAQKEKEE--WERKQRELQEQEWKKQLELEKRLEKQRELERQ 435
Query: 2641 REELQQKKGTYQYDLERLRAAQKQLER----EQEQLRREAERLSQRQTERD 2687
REE ++K D+ER AA+++LER E E++RR+ E L+Q+ E++
Sbjct: 436 REEERRK------DIERREAAKQELERQRRLEWERIRRQ-ELLNQKNREQE 479
Score = 51.2 bits (121), Expect = 1e-05
Identities = 39/148 (26%), Positives = 76/148 (51%), Gaps = 19/148 (12%)
Query: 2551 EDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWE 2610
ED++ ER R +L+EQ+++ + K +++ +++Q + E++ +++ E E
Sbjct: 364 EDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELE 423
Query: 2611 ARERELREREALLAQREEEVQQ-------GQQDLEKER---------EELQQKKGTYQYD 2654
R + RE E QREEE ++ +Q+LE++R +EL +K Q +
Sbjct: 424 KRLEKQRELER---QREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 2655 LERLRAAQKQLEREQEQLRREAERLSQR 2682
+ RL + +K L E E L + +++S R
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGR 508
Score = 48.1 bits (113), Expect = 1e-04
Identities = 32/102 (31%), Positives = 60/102 (58%), Gaps = 8/102 (7%)
Query: 2592 QKQQAQYLEEKRRREREWEARERELREREALLAQREEEV----QQGQQDLEKEREELQQK 2647
QK+ E+KR+ E E E R R+AL+ Q++ E Q+ +++ E+++ ELQ++
Sbjct: 356 QKKLPVTFEDKRKANYERGNMELEKR-RQALMEQQQREAERKAQKEKEEWERKQRELQEQ 414
Query: 2648 KGTYQYDLERLRAAQKQLEREQEQLRR---EAERLSQRQTER 2686
+ Q +LE+ Q++LER++E+ RR E ++++ ER
Sbjct: 415 EWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELER 456
Score = 40.8 bits (94), Expect = 0.019
Identities = 29/100 (29%), Positives = 49/100 (49%), Gaps = 15/100 (15%)
Query: 2576 EKQRSLEKQRQD--LANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQG 2633
EKQR LE+QR++ ++++++A E +R+R EWE R+ LL Q+ E
Sbjct: 427 EKQRELERQREEERRKDIERREAAKQELERQRRLEWER-----IRRQELLNQKNRE---- 477
Query: 2634 QQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLR 2673
++E L KK +LE L +Q+ + +R
Sbjct: 478 ----QEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVR 513
Score = 38.5 bits (88), Expect = 0.095
Identities = 26/113 (23%), Positives = 61/113 (53%), Gaps = 3/113 (2%)
Query: 2581 LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE 2640
L++ R+ Q Q + KR + +E E + EL +++ L + + +QG+++L KE
Sbjct: 647 LKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKE 706
Query: 2641 --REELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQV 2691
R+E ++K+ Q + + + +++ + E++Q R++ + L + +R+ V
Sbjct: 707 NLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-RKDKDTLKAEEKKRETASV 758
Score = 37.4 bits (85), Expect = 0.21
Identities = 26/95 (27%), Positives = 53/95 (55%), Gaps = 8/95 (8%)
Query: 2573 IEQEKQRSLEKQRQDLANLQKQQAQYLEE-KRRREREWEARERELREREALLAQREEEVQ 2631
I+++K + +E++R +L +K + + + K+ +E W+ R+ E E +EE+ Q
Sbjct: 667 IKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRK-EEEEKQKRLQEEKTQ 725
Query: 2632 QGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLE 2666
+ Q+ E++ EE Q+K D + L+A +K+ E
Sbjct: 726 EKIQEEERKAEEKQRK------DKDTLKAEEKKRE 754
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 71.6 bits (174), Expect = 1e-11
Identities = 127/714 (17%), Positives = 264/714 (36%), Gaps = 68/714 (9%)
Query: 376 VERKGEEVEPAPIVD-SGTVSDQDSCLQSLPDCGVKGTEGLSSCGNRNEETGTKSSGMPT 434
+E G++ EP V S T SD +S D K +G + +E G + +
Sbjct: 423 IEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQG-DDPNSSDESNGNDDANSES 481
Query: 435 DQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGI-STTNVSTPDTAGEMEHGLMNPDATV 493
D S S GDA D + G S G E ST++ + D+ G +G + D +
Sbjct: 482 DNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKS- 540
Query: 494 WKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAASSLDGNKPAESSL 553
G+ + ++ + ++ +SD +S S + +S D + ++S
Sbjct: 541 -----DSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDS 595
Query: 554 AFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDGLEPYTLLAAGIGE 613
+ S+ + + ++++ S +S+D+ D + ++ D SD + + +
Sbjct: 596 SDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSD------SNSSD 649
Query: 614 AMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDKLCADSACQQNTVT 673
+ SD +S++++S S SS +DS+ ++
Sbjct: 650 SSDNSD--------------SSDSSNSSNSSDSSDSSD----------SSDSSSSSDSSN 685
Query: 674 SSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSDPVRDTQERADFCP 733
SS + N S+S+ + S D D+S+ + + S D+ +D
Sbjct: 686 SSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSD 745
Query: 734 FKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVISDSTFSLANSPGS 793
N D S+ + D + SDS S +S S
Sbjct: 746 SSDSSNSSDSSDSSDS----------SNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSS 795
Query: 794 ESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDG--NSNEPDTRPLEDRAVGL-STS 850
+S D+ + S ++ + ++D + D +SN D+ D + G S S
Sbjct: 796 DSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDS 855
Query: 851 STAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKATLALDSVLTE 910
S ++ + ++ + + E+ N ++DSS S ++ + +S +
Sbjct: 856 SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915
Query: 911 EGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDTQQFHEKSISA 970
+ S SS + E + SS N+ S + + D+ + S S+
Sbjct: 916 DS-----SNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNS----SDSSNSSDSSNSS 966
Query: 971 DCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPPGASLATESRQ 1030
D + + S+S +S + +++ + + + + ++ S +S ++ S
Sbjct: 967 DSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSD 1026
Query: 1031 EALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSACEVS 1084
+ ++ + S+ D SD SD+ + S S ++ S + + + S
Sbjct: 1027 SSNSSDSSDSS-------DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1073
Score = 60.8 bits (146), Expect = 2e-08
Identities = 122/747 (16%), Positives = 276/747 (36%), Gaps = 49/747 (6%)
Query: 304 AQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIVEEE 363
+ D S+ ++ + + +D S S +++S S + ++S D S +
Sbjct: 590 SSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSD 649
Query: 364 NTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQ----DSCLQSLPDCGVKGTEGLSSCG 419
++D S + + + + DS + SD DS S + ++ S
Sbjct: 650 SSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSD 709
Query: 420 NRNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDT- 478
+ + ++ S+ +D +S +S D+ + ++ S+ + S ++ S+ +
Sbjct: 710 SDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSD 769
Query: 479 ---AGEMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPN 535
+ + + D+ N +S+ +++ ++ +SD S D + +
Sbjct: 770 SSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSD----SSDSDSSNSSD 825
Query: 536 CAPAASSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKD 595
+ ++ S D + ++SS + + + S ++ S + +S+D+ NS +
Sbjct: 826 SSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNS-----SDSS 880
Query: 596 KISDGLEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICST 655
SD E + S SD + D NS +S + S +S S
Sbjct: 881 DSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSN 940
Query: 656 TGDDKLCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAH 715
+ D +DS+ ++ SS + + S S ++ S D D+S D
Sbjct: 941 SSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDS 1000
Query: 716 TVTSDPVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVP 775
+ +SD D+ + +D D +N + +
Sbjct: 1001 SNSSDS-SDSSDSSD---------SSNSSDSSNSSDSSNSSD----------SSDSSDSS 1040
Query: 776 DQAVISDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEP 835
D + SDS+ S +S S+S D+ S + + + +++ D D +SN
Sbjct: 1041 DSSDSSDSSDSSDSSNSSDSSDSSDS-----SDSSDSSDSSDSSDSSESSDSSD-SSNSS 1094
Query: 836 DTRPLEDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQ 895
D+ D S SS +++ ++ + + ++ N ++DSS
Sbjct: 1095 DSSDSSDS----SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSES 1150
Query: 896 S-VGKATLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTP 954
S ++ + DS + + S S+ D + + S + S + +
Sbjct: 1151 SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1210
Query: 955 PPGQDTQQFHEKSISADCA-KDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGA 1013
D+ + S S+D + +++ S+S +S + +++ + + + S
Sbjct: 1211 SDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESD 1270
Query: 1014 AQSLVPPGASLATESRQEALGAEHNSS 1040
+QS G + ++S ++ G++ N S
Sbjct: 1271 SQSKSGNGNNNGSDSDSDSEGSDSNHS 1297
Score = 47.4 bits (111), Expect = 2e-04
Identities = 76/366 (20%), Positives = 126/366 (34%), Gaps = 11/366 (3%)
Query: 1436 ESGSDSDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQ 1495
+S SDS S S D DS + D + SS S++ + S D S S S S
Sbjct: 621 DSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSS 680
Query: 1496 ILKPNRSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSM 1555
N S S D S S+S+ +D D ++ S S+
Sbjct: 681 SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS 740
Query: 1556 RSLSPFRRHSWGPGKNAASDAEMNHRSMSWCPSGVQYSAGLSADFNYRSFSLEGL-TGGA 1614
S S + +SD+ + S S + S+D N S S + + +
Sbjct: 741 SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNS 800
Query: 1615 GVGNKPSSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSK 1674
+ S S + S ++ + + DS S + D D +RS
Sbjct: 801 SDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSD 860
Query: 1675 QQGFNYCTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPH 1734
N S+ SS + S + S D++ +S+ + S+N ++S + ++ N
Sbjct: 861 SS--NSSDSSDSSDSSNS----SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSN---- 910
Query: 1735 SPSKKDSEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVN 1794
S DS S + S S N SS S + +S D + +
Sbjct: 911 SSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSD 970
Query: 1795 GHTFSS 1800
++ S
Sbjct: 971 SNSSDS 976
Score = 45.8 bits (107), Expect = 6e-04
Identities = 82/389 (21%), Positives = 130/389 (33%), Gaps = 9/389 (2%)
Query: 1401 DAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSDSDLFHSPSDDMDSIIFPKPE 1460
D+++ S S + N D + ++ SDS + SD DS
Sbjct: 736 DSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSS 795
Query: 1461 EEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQIL--KPNRSRDRQSLDGFYSHGMGA 1518
+ + D + SS S+D + S D SS+ SD S S N S S D +
Sbjct: 796 DSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDS 855
Query: 1519 EGRESESEPADPGDVEE--EEMDSITEVPANCSVLRSSMRSLSPFRRHSWGPGKNAASDA 1576
R S +D D + DS +N S SS S S S + +SD+
Sbjct: 856 SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNES-SNSSDSSDSSNSSDSDSSDSSNSSDS 914
Query: 1577 EMNHRSMSWCPSGVQYSAGLSADFNYRSFSLEGLTGGAGVGNKPSSSLEVSSANAEELRH 1636
+ S S S+D + S S + + N SS S+N+ +
Sbjct: 915 SDSSNSSDSSESSNSSDNSNSSDSSNSSDS----SDSSDSSNSSDSSNSSDSSNSSDSSD 970
Query: 1637 PFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNYCTSAISSPLTKSISLM 1696
S + S S S + +S S + +++ S + S
Sbjct: 971 SNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNS 1030
Query: 1697 TISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKDSEWKSGTKVSRTFSYI 1756
+ S D+S S+ + S++ + S + + S DS S + S S
Sbjct: 1031 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDS 1090
Query: 1757 KNKMSSSKKSKEKEKEKDKIKEKEKDSKD 1785
N SS S + DS D
Sbjct: 1091 SNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1119
Score = 43.5 bits (101), Expect = 0.003
Identities = 109/572 (19%), Positives = 197/572 (34%), Gaps = 28/572 (4%)
Query: 1427 TSKQGVLKRESGSDSDLFHSPS--------DDMDSIIFPKPEEEHLACDITGSSSSTDDT 1478
+ +G +S S SD +S S DD D K + + D + SS+S+D +
Sbjct: 505 SDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSS 564
Query: 1479 ASLDRHSSHGSDVSLSQILKPNRSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEM 1538
S D SS + S S + S S S+ + S+ +D D + +
Sbjct: 565 DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS 624
Query: 1539 DSITEVPANCSVLRSSMRSLSPFRRHSWGPGKNAASDAEMNHRSMSWCPSGVQYSAGLSA 1598
DS + S +S S S + +SD+ + S S + S+
Sbjct: 625 DSSKSESDSSD---SDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSS 681
Query: 1599 DFNYRSFSLEGL-TGGAGVGNKPSSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLES 1657
D + S S + + + + S S + S+++ + + S + + S+ S
Sbjct: 682 DSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSS 741
Query: 1658 DQREHRMFDQQICHRSKQQGFNYCTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTS 1717
D + N S+ SS + S S + S D+S +S+ N S
Sbjct: 742 DSSD------------SSDSSNSSDSSDSSDSSNS-SDSSDSSDSSDSSDSSNSSDSNDS 788
Query: 1718 ANLTESITEENYNFLPHSPSKKDSEWKSGTKVSRTF-SYIKNKMSSSKKSKEKEKEKDKI 1776
+N ++S N + +S DS S + S + S + S S S + D
Sbjct: 789 SNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSS 848
Query: 1777 KEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTN-KDAYTCANCSAFVHKGC 1835
+ DS ++ + + S S S +N D+ +N S
Sbjct: 849 DGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDS 908
Query: 1836 RESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFA 1895
S S S + D S+ + S + S+ ++ +
Sbjct: 909 SNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDS 968
Query: 1896 NRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTES-LTDEG 1954
+ + S S + S + + +D + S+ S S+DS + N S S +D
Sbjct: 969 SDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSS 1028
Query: 1955 VGTDMNEGQLLGDFEIESKQLEAESWSRIIDS 1986
+D ++ D S ++ S DS
Sbjct: 1029 NSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDS 1060
Score = 42.0 bits (97), Expect = 0.009
Identities = 73/350 (20%), Positives = 120/350 (34%), Gaps = 6/350 (1%)
Query: 1437 SGSDSDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRH-SSHGSDVSLSQ 1495
S SDS + SD DS E + D + SS S++ + S D SS+ SD S S
Sbjct: 901 SDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSS 960
Query: 1496 ILKPNRSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSM 1555
+ S S D S + S+ +D D + DS ++ S S
Sbjct: 961 ----DSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSD-SSDSSDSSNSSDSSDSSDSSDS 1015
Query: 1556 RSLSPFRRHSWGPGKNAASDAEMNHRSMSWCPSGVQYSAGLSADFNYRSFSLEGLTGGAG 1615
+ S S + +SD+ + S S + S+D + S S +
Sbjct: 1016 SNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDS 1075
Query: 1616 VGNKPSSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQ 1675
+ SS SS ++ S + S S S + +S + S
Sbjct: 1076 SDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1135
Query: 1676 QGFNYCTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHS 1735
+ + + S + S + S D+S S+ + S+N ++S + + S
Sbjct: 1136 SDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS 1195
Query: 1736 PSKKDSEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKD 1785
DS S + S S + SS S + + DS D
Sbjct: 1196 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSD 1245
Score = 41.2 bits (95), Expect = 0.015
Identities = 76/387 (19%), Positives = 125/387 (32%), Gaps = 9/387 (2%)
Query: 1408 SKQSPECENFLDVGLGRECTSKQGVLKRESGSDSDLFH-----SPSDDMDSIIFPKPEEE 1462
S S + N D + GSDSD + + SD DS +
Sbjct: 820 SSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDS 879
Query: 1463 HLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPNRSRDRQSLDGFYSHGMGAEGRE 1522
+ D SS+S+D + S + S SD S S + + S S +
Sbjct: 880 SDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSS 939
Query: 1523 SESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSPFRRHSWGPGKNA----ASDAEM 1578
+ S+ +D D S + +N S S S S +S ++ +SD+
Sbjct: 940 NSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSD 999
Query: 1579 NHRSMSWCPSGVQYSAGLSADFNYRSFSLEGLTGGAGVGNKPSSSLEVSSANAEELRHPF 1638
+ S S + S+D + S S + SS SS +++
Sbjct: 1000 SSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD 1059
Query: 1639 SGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNYCTSAISSPLTKSISLMTI 1698
S + S S S + +S + S + + + S + S +
Sbjct: 1060 SSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1119
Query: 1699 SHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKDSEWKSGTKVSRTFSYIKN 1758
S D+S S+ + S+N ++S + S DS S + S S N
Sbjct: 1120 SSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSN 1179
Query: 1759 KMSSSKKSKEKEKEKDKIKEKEKDSKD 1785
SS S + DS D
Sbjct: 1180 SSDSSDSSDSSDSSDSSDSSDSSDSSD 1206
Score = 39.3 bits (90), Expect = 0.056
Identities = 72/393 (18%), Positives = 120/393 (30%), Gaps = 7/393 (1%)
Query: 1408 SKQSPECENFLDVGLGRECTSKQGVLKRESGSDSDLFHSPSDDMDSIIFPKPEEEHLACD 1467
SK N D + + SDS S DS + + +
Sbjct: 638 SKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSN 697
Query: 1468 ITGSSSSTDDTASLDRHSSHGSDVSLSQILKPNRSRDRQSLDGFYSHGMGAEGRESESEP 1527
+ SS S+D S D SS SD S S + S S D S S S
Sbjct: 698 SSESSDSSD---SSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSD 754
Query: 1528 ADPGDVEEEEMDSITEVPANCSVLRSSMRSLSPFRRHSWGPGKNAASDAEMNHRSMSWCP 1587
+ DS ++ S S+ + S + +SD+ + S
Sbjct: 755 SSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSD 814
Query: 1588 SGVQYSAGLSADFNYRSFSLEGLTGGAGVGNKPSSSLEVSSANAEELRHPFSGEERVDSL 1647
S S+ S N S + + + S + S+N + + + DS
Sbjct: 815 SSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSS 874
Query: 1648 VSLSEEDLESDQREHRMFDQQICHRSKQQGFNYCTSAISSPLTKSISLMTISHPGLDNSR 1707
S D D S + +++ S + + S + S DNS
Sbjct: 875 NSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSN 934
Query: 1708 PFHSTFHNTSANLTESITEENYNFLPHSPSKKDSEWKSGTKVSRTFSYIKNKMSSSKKSK 1767
S+ + S++ ++S + + S + DS + + S + N SS S
Sbjct: 935 SSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDS----SNSSDSSDSSD 990
Query: 1768 EKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSS 1800
+ DS D + N S+
Sbjct: 991 SSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSN 1023
Score = 33.9 bits (76), Expect = 2.3
Identities = 66/348 (18%), Positives = 120/348 (34%), Gaps = 10/348 (2%)
Query: 1401 DAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSDSDLFHSP--SDDMDSIIFPK 1458
D+++ S S + N D + ++ S SD +S SD DS
Sbjct: 937 DSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSD 996
Query: 1459 PEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPNRSRDRQSLDGFYSHGMGA 1518
+ + D + SS S+D + S D +S S S + S S D S
Sbjct: 997 SSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSN 1056
Query: 1519 EGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSPFRRHSWGPGKNAASDAEM 1578
S+S + + DS ++ S S+ S S + +SD+
Sbjct: 1057 SSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD 1116
Query: 1579 NHRSMSWCPSGVQYSAGLSADFNYRSFSLEGLTGGAGVGNKPSSSLEVSSANAEELRHPF 1638
+ S + S + S+D + S S + + SS SS +++
Sbjct: 1117 SSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSD 1176
Query: 1639 SGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNYCTSAISSPLTKSISLMTI 1698
S S S S + +S S + + + S + + +
Sbjct: 1177 SSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSD 1236
Query: 1699 SHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKDSEWKSG 1746
S D+S +S+ + S++ ++S ++ N + DS+ KSG
Sbjct: 1237 SSDSSDSSDSSNSSDSSDSSDSSDSTSDSN--------DESDSQSKSG 1276
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.127 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 113,479,611
Number of Sequences: 37866
Number of extensions: 5710966
Number of successful extensions: 53116
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 598
Number of HSP's successfully gapped in prelim test: 1168
Number of HSP's that attempted gapping in prelim test: 25360
Number of HSP's gapped (non-prelim): 16423
length of query: 2817
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2697
effective length of database: 13,703,598
effective search space: 36958603806
effective search space used: 36958603806
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.