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Search of human proteins with 31543392
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31543392 peroxisome proliferator-activated receptor gamma,
coactivator 1 beta [Homo sapiens]
(1023 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31543392 peroxisome proliferator-activated receptor gamma, co... 2102 0.0
gi|7019499 peroxisome proliferator-activated receptor gamma, coa... 209 8e-54
gi|40807452 peroxisome proliferator-activated receptor gamma, co... 150 5e-36
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 64 6e-10
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 56 2e-07
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 54 6e-07
gi|58761548 tau tubulin kinase 1 [Homo sapiens] 53 2e-06
gi|55741677 SET domain containing 1A [Homo sapiens] 52 4e-06
gi|24431935 reticulon 4 isoform A [Homo sapiens] 51 5e-06
gi|239745093 PREDICTED: hypothetical protein XP_002343359 [Homo ... 51 6e-06
gi|118600967 shroom family member 4 [Homo sapiens] 50 1e-05
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex... 50 1e-05
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 50 1e-05
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 49 2e-05
gi|148762982 hypothetical protein LOC387640 [Homo sapiens] 49 2e-05
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 49 3e-05
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 49 3e-05
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 49 3e-05
gi|215490093 ATPase, (Na+)/K+ transporting, beta 4 polypeptide i... 49 3e-05
gi|6912256 ATPase, (Na+)/K+ transporting, beta 4 polypeptide iso... 49 3e-05
gi|17975763 myelin transcription factor 1 [Homo sapiens] 48 4e-05
gi|11119430 testis-specific kinase substrate [Homo sapiens] 48 4e-05
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 48 5e-05
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 48 5e-05
gi|157266334 tubby like protein 1 [Homo sapiens] 48 5e-05
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 47 7e-05
gi|224994221 SH3-domain binding protein 2 isoform b [Homo sapiens] 47 9e-05
gi|224994219 SH3-domain binding protein 2 isoform c [Homo sapiens] 47 9e-05
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens] 47 9e-05
gi|170014705 SH3-domain binding protein 2 isoform a [Homo sapiens] 47 9e-05
>gi|31543392 peroxisome proliferator-activated receptor gamma,
coactivator 1 beta [Homo sapiens]
Length = 1023
Score = 2102 bits (5446), Expect = 0.0
Identities = 1023/1023 (100%), Positives = 1023/1023 (100%)
Query: 1 MAGNDCGALLDEELSSFFLNYLADTQGGGSGEEQLYADFPELDLSQLDASDFDSATCFGE 60
MAGNDCGALLDEELSSFFLNYLADTQGGGSGEEQLYADFPELDLSQLDASDFDSATCFGE
Sbjct: 1 MAGNDCGALLDEELSSFFLNYLADTQGGGSGEEQLYADFPELDLSQLDASDFDSATCFGE 60
Query: 61 LQWCPENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGD 120
LQWCPENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGD
Sbjct: 61 LQWCPENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGD 120
Query: 121 ALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWR 180
ALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWR
Sbjct: 121 ALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWR 180
Query: 181 QAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSP 240
QAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSP
Sbjct: 181 QAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSP 240
Query: 241 RLPAKEDKEPGEDCPSPQPAPASPQDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLP 300
RLPAKEDKEPGEDCPSPQPAPASPQDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLP
Sbjct: 241 RLPAKEDKEPGEDCPSPQPAPASPQDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLP 300
Query: 301 QRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDVSKPYR 360
QRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDVSKPYR
Sbjct: 301 QRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDVSKPYR 360
Query: 361 LATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREV 420
LATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREV
Sbjct: 361 LATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREV 420
Query: 421 RRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSR 480
RRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSR
Sbjct: 421 RRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSR 480
Query: 481 RLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGP 540
RLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGP
Sbjct: 481 RLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGP 540
Query: 541 QIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCG 600
QIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCG
Sbjct: 541 QIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCG 600
Query: 601 TAGLTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPE 660
TAGLTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPE
Sbjct: 601 TAGLTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPE 660
Query: 661 RSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLE 720
RSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLE
Sbjct: 661 RSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLE 720
Query: 721 DWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDL 780
DWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDL
Sbjct: 721 DWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDL 780
Query: 781 ASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSP 840
ASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSP
Sbjct: 781 ASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSP 840
Query: 841 PSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGE 900
PSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGE
Sbjct: 841 PSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGE 900
Query: 901 GRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTK 960
GRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTK
Sbjct: 901 GRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTK 960
Query: 961 GAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSKYEAMDFDSLLKEAQQ 1020
GAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSKYEAMDFDSLLKEAQQ
Sbjct: 961 GAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSKYEAMDFDSLLKEAQQ 1020
Query: 1021 SLH 1023
SLH
Sbjct: 1021 SLH 1023
>gi|7019499 peroxisome proliferator-activated receptor gamma,
coactivator 1 alpha [Homo sapiens]
Length = 798
Score = 209 bits (533), Expect = 8e-54
Identities = 181/550 (32%), Positives = 257/550 (46%), Gaps = 106/550 (19%)
Query: 571 PRCLMLALSQSDPT------FGKKSFEQTLTVELCGTAGLTPPTTPPYKPTEEDPFKPDI 624
P L L L+ P F K+ E+TL+VEL GTAGLTPPTTPP+K +++PF+
Sbjct: 255 PTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASP 314
Query: 625 KHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPERSELLSHLRHATAQPASQAGQK-- 682
K + + PS + +++ + KK PE+SEL + L ++ +K
Sbjct: 315 KLKSSCKTVVPPPSKKPRYSESSGTQGNNSTKKGPEQSELYAQLSKSSVLTGGHEERKTK 374
Query: 683 RPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLE------DWPQQGAPWAEA-QAP 735
RP FGDHDYCQ + + + + + + S LE DW Q ++ Q
Sbjct: 375 RPSLRLFGDHDYCQSINSKTEILINISQELQDSR-QLENKDVSSDWQGQICSSTDSDQCY 433
Query: 736 GREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDS 795
RE + +P L+D EIRA L KHFG A+ +++ + K+ E DS
Sbjct: 434 LRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDE--ADKTGE----LRDS 487
Query: 796 SSSSGESSFLP-------------EEEEEEGEEEEEDDEEEDS----GVSPTCSD-HCPY 837
S+ + S LP ++ E+E ++ + S VSP+CS + P
Sbjct: 488 DFSNEQFSKLPMFINSGLAMDGLFDDSEDESDKLSYPWDGTQSYSLFNVSPSCSSFNSPC 547
Query: 838 Q---SPP----SKANRQLCSRSRSSSGSSPC--------HSWSPATRRN----------- 871
+ SPP S+ +++ SRSRS S C S SP +R +
Sbjct: 548 RDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSH 607
Query: 872 ------------FRCESRGPCS-----DRTPSIRHARKRRE------------------- 895
R SR P S D +H R +RE
Sbjct: 608 YRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEEYQHERLKREEYRREYEKRESERAKQRER 667
Query: 896 ---KAIGEGRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSE 952
KAI E RV+Y+ + D + EL+ RFEVFGEIEEC V R+ G+ YGFITYR +
Sbjct: 668 QRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDD-GDSYGFITYRYTC 726
Query: 953 HAALSLTKGAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSKYEAMDFD 1012
A +L G LR+ NE F+L + G + F Y D DSNS++ PAS KSKY+++DFD
Sbjct: 727 DAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFD 786
Query: 1013 SLLKEAQQSL 1022
SLLKEAQ+SL
Sbjct: 787 SLLKEAQRSL 796
Score = 114 bits (285), Expect = 5e-25
Identities = 82/202 (40%), Positives = 114/202 (56%), Gaps = 19/202 (9%)
Query: 31 GEEQ-LYADFPELDLSQLDASDFDSATCFGELQWCPENSETEPNQYSPDDSELFQ-IDSE 88
GE+Q L D PELDLS+LD +D D+ + G L+WC + SE NQY+ + S +F+ ID E
Sbjct: 24 GEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPSNIFEKIDEE 83
Query: 89 NEA-LLAELTKTLDDIPEDDVGLAAFPALDGGDALSCTSASPAPSSAPPSPAPEKPSAPA 147
NEA LLA LT+TLD +P D+ GL +F AL GD + ASP S+ P P P
Sbjct: 84 NEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTDNEASP---SSMPDGTP-----PP 135
Query: 148 PEVDELSLLQKLLLATSYPTSSSDTQKEGTAWR---QAGLRSKSQRPCVKADSTQDKKA- 203
E +E SLL+KLLLA + T S + G + + R ++ VK +++ KA
Sbjct: 136 QEAEEPSLLKKLLLAPA-NTQLSYNECSGLSTQNHANHNHRIRTNPAIVKTENSWSNKAK 194
Query: 204 ---PMMQSQSRSCTELHKHLTS 222
+ Q R C+EL K+LT+
Sbjct: 195 SICQQQKPQRRPCSELLKYLTT 216
>gi|40807452 peroxisome proliferator-activated receptor gamma,
coactivator-related 1 [Homo sapiens]
Length = 1664
Score = 150 bits (380), Expect = 5e-36
Identities = 264/1047 (25%), Positives = 369/1047 (35%), Gaps = 186/1047 (17%)
Query: 101 DDIPEDDVGLAAFPALDGGDALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQKLL 160
D P D V + + P A+S AP S + + P PEV E+ K+
Sbjct: 677 DLTPVDPVLVKSRPTDPRRGAVSSALGGSAPQLLVESESLDPPKTIIPEVKEVVDSLKIE 736
Query: 161 LATSYPTSSSDTQKEGTAWRQAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHL 220
TS T + R L +R + T+++ + S E L
Sbjct: 737 SGTSATTHEARP-------RPLSLSEYRRRRQQRQAETEERSPQPPTGKWPSLPETPTGL 789
Query: 221 TSAQCCLQDRGLQPPCLQSPRLPAKED------KEPGEDCPSPQ-PAPASPQDSLALGRA 273
PCL P PAK+ + P E C P P+PASP + +
Sbjct: 790 ADI-----------PCLVIPPAPAKKTALQRSPETPLEICLVPVGPSPASPSPEPPVSKP 838
Query: 274 DPGAPVSQEDMQAMVQLIRYMH---------------TYCLPQRK----LPPQTPEPLPK 314
+P Q Q M L R + LP +PP P P +
Sbjct: 839 VASSPTEQVPSQEMPLLARPSPPVQSVSPAVPTPPSMSAALPFPAGGLGMPPSLPPPPLQ 898
Query: 315 ACSNPSQQ--VRSRPWSRHHSKASWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPR 372
S P V P++ + SW + + C P T S TP
Sbjct: 899 PPSLPLSMGPVLPDPFTHYAPLPSWPCYP---HVSPSGYPCLPPPP----TVPLVSGTPG 951
Query: 373 SRPRPPKDSQ--ASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQE 430
+ PP S A P P S P GP P P V PA + +
Sbjct: 952 AYAVPPTCSVPWAPPPAPVSPYSSTCTYGPLGWGPGPQHAPFWSTVPPPPLPPASIGRAV 1011
Query: 431 EEDEEEEEEEEEEEKEE------EEEWGRKRPGRGLPWTKLGRKLESSVCPVR------- 477
+ + E E PG G P T+ K+E P
Sbjct: 1012 PQPKMESRGTPAGPPENVLPLSMAPPLSLGLPGHGAPQTE-PTKVEVKPVPASPHPKHKV 1070
Query: 478 -------------------------RSRRLNPELGPWLTFADEPL-----VPSEPQGALP 507
S RL PE PL VP+ Q +P
Sbjct: 1071 SALVQSPQMKALACVSAEGVTVEEPASERLKPETQETRPREKPPLPATKAVPTPRQSTVP 1130
Query: 508 SLCLAPKAYDVE-RELGS-PTDEDSGQDQQLLRGPQIPALESPCESGCGDMDEDPS---- 561
L P + R+L PT G + + +E+ S + E
Sbjct: 1131 KL---PAVHPARLRKLSFLPTPRTQGSEDVVQAFISEIGIEASDLSSLLEQFEKSEAKKE 1187
Query: 562 CPQLPPRDSPRCLMLALSQS---DPTFGKKSFEQTLTVELCGTAGLTPPTTPPYKPTEED 618
CP P DS LA+ S D K+ ++ EL AGLTPP TPP
Sbjct: 1188 CPPPAPADS-----LAVGNSGGVDIPQEKRPLDRLQAPELANVAGLTPPATPP------- 1235
Query: 619 PFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPERSELLSHLRHATAQPASQ 678
H L K +A +SL A + ++ + E ++ +H A +
Sbjct: 1236 -------HQLWKPLA-------AVSLLAKAKSPKSTAQEGTLKPEGVTEAKHPAAVRLQE 1281
Query: 679 A--GQKRPFSCSFGDHDYCQVLRP-----EGVLQRKVLRSW---EPSGVHLEDWPQQG-- 726
G R S GDHDYC R ++ +V W + ++ G
Sbjct: 1282 GVHGPSRVHVGS-GDHDYCVRSRTPPKKMPALVIPEVGSRWNVKRHQDITIKPVLSLGPA 1340
Query: 727 APWAEAQAPGRE--EDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASCK 784
AP A RE + R+ A P L + + + T E A +
Sbjct: 1341 APPPPCIAASREPLDHRTSSEQADPSAPCLAPSSLLSPEASPCRNDMNTRTPPEPSAKQR 1400
Query: 785 SPE-YDTVFEDSSSSS-------GESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCP 836
S Y +S SS G +S G + S S +
Sbjct: 1401 SMRCYRKACRSASPSSQGWQGRRGRNS----RSVSSGSNRTSEASSSSSSSSSSSRSRSR 1456
Query: 837 YQSPPSKA-NRQLCS------RSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRTPSIR- 888
SPP K R CS R SSS SS S S ++ + R SR P R R
Sbjct: 1457 SLSPPHKRWRRSSCSSSGRSRRCSSSSSSSSSSSSSSSSSSSSRSRSRSPSPRRRSDRRR 1516
Query: 889 ---------HARKRR----EKAIGEGRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLT 935
H +++R E+AI E RVV+I + M+ ELK+RF VFGEIEEC +
Sbjct: 1517 RYSSYRSHDHYQRQRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHF 1576
Query: 936 RNRRGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSE 995
R +G+ YGF+TYR +E A ++ G LR+ +E F L +GG R FC Y+D DSN E
Sbjct: 1577 R-VQGDNYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLDSNRE 1635
Query: 996 EALPASGKSKYEAMDFDSLLKEAQQSL 1022
+ PA KSK++++DFD+LLK+AQ++L
Sbjct: 1636 DFDPAPVKSKFDSLDFDTLLKQAQKNL 1662
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 64.3 bits (155), Expect = 6e-10
Identities = 115/475 (24%), Positives = 177/475 (37%), Gaps = 84/475 (17%)
Query: 380 DSQASPGRPSSVEEVRIAASPKS---TGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEE 436
+S+ SP + S + SP+S TG R L L E E +++EEE+EEE
Sbjct: 1031 NSRQSPAKVQSKN--KYLHSPESRPVTGERGQLLELSKESSEEEEEEEDEEEEEEEEEEE 1088
Query: 437 E--EEEEEEEKEEEEEWGRKRPGR-GLPWTKLGRKLESSVCPVRRS---RRLNPE----- 485
E EEEEEEE+EEEEE + P R P + ++ V +R RR+N
Sbjct: 1089 EDEEEEEEEEEEEEEENIQSSPPRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTET 1148
Query: 486 LGPWLTFADEPLVPSEPQGALPSL---C-----------LAPKAYDVERELGSPTDEDSG 531
+ +EP S+ + +P L C + KA+ + T+E+ G
Sbjct: 1149 ISETTEVLNEPFDNSDEERPMPQLEPTCEIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEG 1208
Query: 532 QDQQLLRGP-----QIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFG 586
+D + + S + G D E C Q+ P+ + R L +
Sbjct: 1209 KDNHCFKNADPCRNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQNKE---R 1265
Query: 587 KKSFEQTLTVELCGTAGLTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLKA 646
K F+ L TPP T P +P E+ + + S GK + PSP + +
Sbjct: 1266 KTGFKLNL---------YTPPET-PMEPDEQVTVEEQKETSEGK----TSPSPIRIEEEV 1311
Query: 647 TPGAAHKLPKKHPERSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGVLQR 706
LP++ R E T P S + S G+ +++PE +
Sbjct: 1312 KETGEALLPQEENRREE--------TCAPVSP-------NTSPGEKPEDDLIKPEEEEEE 1356
Query: 707 KVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTK 766
+ E E+ G + +E + +DS L DHE
Sbjct: 1357 EEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLDDHEEE----- 1411
Query: 767 HFGLLETALEEEDLASCKSPEYDTVFEDSS---SSSGESSFLPEEEEEEGEEEEE 818
EEED + ++D ED S S+ E LP E +E E +E
Sbjct: 1412 ---------EEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLENQE 1457
Score = 38.9 bits (89), Expect = 0.025
Identities = 23/55 (41%), Positives = 28/55 (50%)
Query: 787 EYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSPP 841
E + E S SS E +EEEEE EEEEE+DEEE+ + SPP
Sbjct: 1057 ERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPP 1111
Score = 35.8 bits (81), Expect = 0.21
Identities = 16/32 (50%), Positives = 20/32 (62%)
Query: 795 SSSSSGESSFLPEEEEEEGEEEEEDDEEEDSG 826
S E + EEEEE EEEEE++EEE+ G
Sbjct: 1338 SPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEG 1369
Score = 34.3 bits (77), Expect = 0.62
Identities = 15/20 (75%), Positives = 17/20 (85%)
Query: 807 EEEEEEGEEEEEDDEEEDSG 826
EEEEEE EEEEE+ EEE+ G
Sbjct: 1356 EEEEEEEEEEEEEGEEEEGG 1375
Score = 33.9 bits (76), Expect = 0.81
Identities = 18/51 (35%), Positives = 26/51 (50%)
Query: 796 SSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSPPSKANR 846
S S E E+EEEE EEEEE+++EE+ + QS P + +
Sbjct: 1065 SKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPRLTK 1115
Score = 33.1 bits (74), Expect = 1.4
Identities = 15/20 (75%), Positives = 16/20 (80%)
Query: 807 EEEEEEGEEEEEDDEEEDSG 826
EEEEEE EEEEE +EEE G
Sbjct: 1357 EEEEEEEEEEEEGEEEEGGG 1376
Score = 32.7 bits (73), Expect = 1.8
Identities = 14/20 (70%), Positives = 17/20 (85%)
Query: 807 EEEEEEGEEEEEDDEEEDSG 826
EEEEEE EEEEE++ EE+ G
Sbjct: 1355 EEEEEEEEEEEEEEGEEEEG 1374
Score = 32.0 bits (71), Expect = 3.1
Identities = 18/44 (40%), Positives = 23/44 (52%)
Query: 782 SCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDS 825
S +S E + ED E +EEEEE EEEEE++E S
Sbjct: 1065 SKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQS 1108
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 55.8 bits (133), Expect = 2e-07
Identities = 166/722 (22%), Positives = 230/722 (31%), Gaps = 104/722 (14%)
Query: 65 PENSETEP----NQYSPDDSELFQIDSENEALLAELTKTLDDIP----EDDVGLAAFPAL 116
PE S T P ++ SP EL EAL L++ L++ P ++ L+ P
Sbjct: 453 PEESPTSPPPEASRLSPPPEEL-PASPLPEAL--HLSRPLEESPLSPPPEESPLSPPPES 509
Query: 117 DGGDALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQKLLLATSYPTSSSDTQKEG 176
L + SP P +PPSPA E P +P PE LS + S E
Sbjct: 510 SPFSPLEESPLSP-PEESPPSPALETPLSPPPEASPLS--------PPFEESPLSPPPEE 560
Query: 177 TAWRQAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPC 236
S P S +++PM S + ++ L PP
Sbjct: 561 LP--------TSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPP 612
Query: 237 LQSPRLPAKEDKE---PGEDCPS---PQPAPASPQDSLA-------LGRADPG---APVS 280
+SP P E P ED P P+ +P SP ++ + R P +P+S
Sbjct: 613 EESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLS 672
Query: 281 QEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEF 340
++ P P P A P + S P E
Sbjct: 673 PPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLP----------LEE 722
Query: 341 SILRELLAQDVLCDVSK-PYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAA- 398
S L L + LC S+ P+ P L+PR P EE + A
Sbjct: 723 SPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAV 782
Query: 399 ------SPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWG 452
SP++ GP S +P L + + P EE + EE + EE
Sbjct: 783 PEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCL 842
Query: 453 RKRPGRGLPWTKLGRKLESSVCPVRRSRRLNPELGPWLTFADEPLVPSEPQGALPSLCLA 512
RP ES + P L+P P P E P C A
Sbjct: 843 SPRPE------------ESHLSPELEKPPLSP----------RPEKPPEE----PGQCPA 876
Query: 513 PKAYDVERELGSPTDEDSGQDQQLLRGPQIPALESPCESGCGDMDEDPSCPQL-PPRDSP 571
P+ + G P+ + L + P P E E PQL PP P
Sbjct: 877 PEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLP 936
Query: 572 RCLMLALSQSDPTFGKKSFEQTLTVELCGTAGLTPPTTPPYKPTEEDPFKPDIKHSLGK- 630
L ++ + P E G G + P +P P E P P + +
Sbjct: 937 PPLSPIITAAAPPALSPLGELEYPF---GAKGDSDPESPLAAPILETPISPPPEANCTDP 993
Query: 631 ---EIALSLPSPEGLSLKATPGAAHKLPKKHPERSELLSHLRHATAQPASQAGQKR-PFS 686
+ PSP A+P LP P+ S LL H P SQ P S
Sbjct: 994 EPVPPMILPPSPGSPVGPASPILMEPLP---PQCSPLLQHSLVPQNSPPSQCSPPALPLS 1050
Query: 687 CSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAG 746
+ + GV L E V + P P A + P D SC A
Sbjct: 1051 V---PSPLSPIGKVVGVSDEAELHEMETEKVSEPECPAL-EPSATSPLPSPMGDLSCPAP 1106
Query: 747 AP 748
+P
Sbjct: 1107 SP 1108
Score = 33.5 bits (75), Expect = 1.1
Identities = 44/172 (25%), Positives = 61/172 (35%), Gaps = 34/172 (19%)
Query: 239 SPRLPAKEDKEPGEDCPSPQPAPASPQDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYC 298
+PR E + PG +P PA AL + P P + + Y Y
Sbjct: 2332 TPRASQVEPQSPGLGLRPQEPPPAQ-----ALAPSPPSHP-------DIFRPGSYTDPYA 2379
Query: 299 LPQRKLPPQTPEPLPKACSNPSQQVRSRPWSR---HHSKASWAEFSILRELLAQDVLCDV 355
P PQ P P C+ P + + S P+SR S ++ + L+ + C
Sbjct: 2380 QPPLTPRPQPPPP-ESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPS 2438
Query: 356 SKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRP 407
TP + S P SRP P RP S R +P PRP
Sbjct: 2439 P-----VTPRFQSPDPYSRP---------PSRPQS----RDPFAPLHKPPRP 2472
Score = 30.8 bits (68), Expect = 6.8
Identities = 36/131 (27%), Positives = 48/131 (36%), Gaps = 20/131 (15%)
Query: 523 GSPTDEDSGQDQQLLRGPQIPALESPCESGCGDMDE---DPSCPQLPPRDSPRCLMLALS 579
GS DS + L PQ+PA + P + G +P P PP P
Sbjct: 2148 GSVPGPDSPGELFLKLPPQVPA-QVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAP 2206
Query: 580 QSDPTFGKKSFEQTLTVELCGTAGLTPPTTPPYKPTEEDPF-KPDIKHSLGKEIALSLPS 638
P G S G TPP TP ++P+ DPF KP PS
Sbjct: 2207 AQPPMLGASSRPGAGQP---GEFHTTPPGTPRHQPSTPDPFLKP------------RCPS 2251
Query: 639 PEGLSLKATPG 649
+ L++ +PG
Sbjct: 2252 LDNLAVPESPG 2262
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 54.3 bits (129), Expect = 6e-07
Identities = 90/396 (22%), Positives = 140/396 (35%), Gaps = 45/396 (11%)
Query: 109 GLAAFPALDGGDALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQKLLLATSYPTS 168
G+ P C S SP P + P +P P S +PE++ L + S
Sbjct: 1465 GMKDIPRTPSRGRSECDS-SPEPKALPQTPRPRSRSPSSPELNNKCLTPQ----RERSGS 1519
Query: 169 SSDTQKEGTAWRQAGLRSK---SQRPCVK----------ADSTQDKKAPM---MQSQSRS 212
S ++ A G RS+ SQ VK +DS+ D KA ++ +SRS
Sbjct: 1520 ESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRS 1579
Query: 213 CTELHKHLTSAQCCLQDRGLQPPCLQ-----SPRLPAKEDKEPGEDCPSPQPAPASPQDS 267
+ S + R P ++ +PR + D P P+P+ P +
Sbjct: 1580 GSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRS- 1638
Query: 268 LALGRADPGAPVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRP 327
G + G S E + T P+ PP++ + S+P + +SR
Sbjct: 1639 ---GSSSKGRGPSPEGSSS---------TESSPEH--PPKSRTARRGSRSSPEPKTKSRT 1684
Query: 328 WSRHHSKASWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPR-SRPRPPKDSQASPG 386
R S S E + L + S R TP +P S P P + S++S
Sbjct: 1685 PPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRR 1744
Query: 387 RPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEE--DEEEEEEEEEEE 444
R S+ S + P P R L+ R R R ++ + + +
Sbjct: 1745 RRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRS 1804
Query: 445 KEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSR 480
+ R+R G G R+ ESS RR R
Sbjct: 1805 RSRSRVTRRRRGGSGYHSRSPARQ-ESSRTSSRRRR 1839
Score = 39.3 bits (90), Expect = 0.019
Identities = 187/891 (20%), Positives = 284/891 (31%), Gaps = 118/891 (13%)
Query: 123 SCTSASP--APSSAPPSPAPEKPSAPAPEVDE-LSLLQKLLLATSYPTSSSDTQKEGTAW 179
SC+ +SP SS PP +P + S+P P+V +S Q+ +S P+ S T
Sbjct: 890 SCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTS------ 943
Query: 180 RQAGLRSKSQRPCVKAD------------STQDKK----APMMQSQSRSCTELHKHLTSA 223
R RS+S PC + S+ D K P QS S S + K
Sbjct: 944 RTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQT 1003
Query: 224 QCCLQDRGLQPPCLQSPRLPAKEDKEPGEDCPSPQPAPASPQDSLALGRADPGAPVSQED 283
G + PC Q K + CP A + S G + G Q
Sbjct: 1004 PPGPSLSGSKSPCPQE-----KSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLK 1058
Query: 284 MQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSR---PWSRHHSKASWAEF 340
Q+ P + +PE +PS Q +S+ R S + E
Sbjct: 1059 GQSQTS----------PDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTEL 1108
Query: 341 SILRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASP 400
+ R + QD + A+P+ S + R DS + P S+ + S
Sbjct: 1109 A-SRSPIRQD------RGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSN---SLLGQSR 1158
Query: 401 KSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGL 460
T L + P + + ++ E K+ R+R G G
Sbjct: 1159 LETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAG- 1217
Query: 461 PWTKLGRKLESSVCPVRRSRRLNPELGPWLTFADEPL--VPSEPQGALPSLCLA--PKAY 516
+ K ++S P + EL + ++EP + S L + + +
Sbjct: 1218 --SSPETKEQNSALPTSSQ---DEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSP 1272
Query: 517 DVERELGSPTDEDSGQDQQLLRGPQIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLML 576
+VE D Q Q L ++P++ S G E P R++ L
Sbjct: 1273 EVEERPAVSLTLDQSQSQASLEAVEVPSMASSW-GGPHFSPEHKELSNSPLRENSFGSPL 1331
Query: 577 ALSQSDP--TFGKKSFEQTLTVELCGTAGLTPPTTPPYKPTEE---------DPFKPDIK 625
S P T F + +L G T P E+ PD
Sbjct: 1332 EFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAV 1391
Query: 626 HSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPERSELLSHLRHATAQPASQAGQKRPF 685
G S+ SP ++ TP PE + L ++ S G +
Sbjct: 1392 EKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLR--- 1448
Query: 686 SCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDA 745
G R L P ++D P+ + GR E CD+
Sbjct: 1449 -------------DGSGTPSRHSLSGSSPG---MKDIPR-------TPSRGRSE---CDS 1482
Query: 746 GAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFE---DSSSSSGES 802
PK R+ + + E S S + TV S SG S
Sbjct: 1483 SPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSS 1542
Query: 803 SFLPEEEEEEGEEEEEDDEEEDSGVS--PTCSDHCPYQSPPSKANRQLCSRSRSSSGSSP 860
L + +E E D DS S P ++ S RS SGSSP
Sbjct: 1543 QELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSP 1602
Query: 861 CHSWSPATRRNFRCESRGPCSDRTPSIRH-ARKRREKAIGEGRVVYIQNLSSDMSSRE-- 917
P + S + P+ R R+ R + +GR + SS SS E
Sbjct: 1603 EVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHP 1662
Query: 918 LKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTKGAALRKRN 968
K R G E T++R + R S ++ LT+ A L +R+
Sbjct: 1663 PKSRTARRGSRSSPEPKTKSRTPPR------RRSSRSSPELTRKARLSRRS 1707
Score = 38.9 bits (89), Expect = 0.025
Identities = 53/247 (21%), Positives = 84/247 (34%), Gaps = 19/247 (7%)
Query: 646 ATPGAAHKLPKKHPERSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGVLQ 705
+ P + ++ P S + + P +Q + P +F D C + + V
Sbjct: 2412 SAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAG 2471
Query: 706 RKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLT 765
+ L S + G APG D G PP + + + A
Sbjct: 2472 SQSLSSGAVATTTSSAGDHNGM--LSVPAPGVPHS---DVGEPPASTGAQQPSALAA--- 2523
Query: 766 KHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDS 825
L+ A E +S S + SSSSS SS + E + +
Sbjct: 2524 -----LQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKR 2578
Query: 826 GVSPTCS------DHCPYQSPPSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGP 879
SPT + + P + P+K R+ S S SSS SS S S ++ + S
Sbjct: 2579 VPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2638
Query: 880 CSDRTPS 886
S + S
Sbjct: 2639 SSSSSSS 2645
Score = 37.4 bits (85), Expect = 0.073
Identities = 102/478 (21%), Positives = 161/478 (33%), Gaps = 79/478 (16%)
Query: 76 SPDDSELFQIDSENEA--------LLAEL----TKTLDDIPEDDVGLAAFPALDGGDALS 123
S D EL ++ ++E L +EL T + PE + A LD + +
Sbjct: 1232 SSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQA 1291
Query: 124 CTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWRQAG 183
A PS A P +PE ELS + P ++ GT G
Sbjct: 1292 SLEAVEVPSMASSWGGPHF----SPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMN-TG 1346
Query: 184 LRSKSQRPC-------VKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPC 236
S+ + ++ D + D K +S S +EL ++ + P
Sbjct: 1347 FSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPV 1406
Query: 237 LQS-PRLPAKEDKEPGEDCPSPQPAPASPQDSLALG-----RADPGAPV------SQEDM 284
L + PR P++E P +P G R G P S M
Sbjct: 1407 LDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGM 1466
Query: 285 QAMVQLIRYMHTYC--LPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSI 342
+ + + + C P+ K PQTP P ++ S+P + R S + E S+
Sbjct: 1467 KDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGS---ESSV 1523
Query: 343 LRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSV-----EEVRIA 397
++ +A+ L S R + + P + P+ +S +SP + + R
Sbjct: 1524 DQKTVARTPLGQRS---RSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSG 1580
Query: 398 ASPK-----STGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWG 452
+SP+ PR S EVK + R R Q + E + G
Sbjct: 1581 SSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRS-G 1639
Query: 453 RKRPGRGL---------------PWTKLGR---------KLESSVCPVRRSRRLNPEL 486
GRG P ++ R K +S P RRS R +PEL
Sbjct: 1640 SSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPEL 1697
Score = 33.9 bits (76), Expect = 0.81
Identities = 55/225 (24%), Positives = 83/225 (36%), Gaps = 35/225 (15%)
Query: 128 SPAPSSAPPSPAPEKP----SAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWRQAG 183
SP P S S ++ + PAP+ A+S TS S ++
Sbjct: 231 SPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTA 290
Query: 184 LRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSPRLP 243
L +S P D AP + + S T+ + QP +
Sbjct: 291 LAGRSPSPASGRRGEGD--APFSEPGTTSTQRPSSPETATK--------QPSSPYEDKDK 340
Query: 244 AKEDKEPGEDCPSPQ-----PAPASPQDSLAL---GRADPGA--PVSQEDMQAMVQLIRY 293
K++K PSP+ P P +P LA G P A P+SQE + +
Sbjct: 341 DKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSE---- 396
Query: 294 MHTYCLPQR-KLPPQTPEPLPKACSNPSQQVRSRPW--SRHHSKA 335
P R + PP++PE LP++ S+ S +P SRH S +
Sbjct: 397 ----ASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSS 437
Score = 32.0 bits (71), Expect = 3.1
Identities = 47/237 (19%), Positives = 83/237 (35%), Gaps = 47/237 (19%)
Query: 167 TSSSDTQKEGTAWRQAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCC 226
+SS K T+ R++ S + + S + + +S+++S L + L+ + C
Sbjct: 726 SSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPC 785
Query: 227 LQDRGLQPPCL------------QSPRLPAKEDKEPGEDCPSPQPAPASPQDSLALGRAD 274
+ + PP ++P ++ P S P+ S S +
Sbjct: 786 PKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVK 845
Query: 275 PGAPVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSK 334
G P Q + + PQ TP+ S+P +++SR SRH
Sbjct: 846 SGTPPRQGSITS-------------PQANEQSVTPQRRSCFESSPDPELKSRTPSRHS-- 890
Query: 335 ASWAEFSILRELLAQDVLCDVSKPYRL--ATPVYASLTPRSRPRPPKDSQASPGRPS 389
C S P R+ +TP S + S P+P + SP + S
Sbjct: 891 ------------------CSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRS 929
Score = 30.4 bits (67), Expect = 8.9
Identities = 23/52 (44%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 839 SPPSKANRQLCSRSRSSSGSSPCHSWSPAT--RRNFRCESRGPCSDRTPSIR 888
SP SKA +L R RS SGSSPC T RR+ S+ RTP R
Sbjct: 764 SPRSKAKSRLSLR-RSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRR 814
>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
Length = 1321
Score = 52.8 bits (125), Expect = 2e-06
Identities = 61/221 (27%), Positives = 85/221 (38%), Gaps = 26/221 (11%)
Query: 240 PRLPAKEDKEPGEDCPSPQPAPASPQDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCL 299
P D+EP E +P P ++ LG A+P MQA+ + L
Sbjct: 561 PSTSGTTDEEPEE----LRPLPEEGEERRRLG-AEPTVRPRGRSMQALAE----EDLQHL 611
Query: 300 PQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDVSKPY 359
P + LPPQ L + P S HS RE D + +
Sbjct: 612 PPQPLPPQ----LSQGDGRSETSQPPTPGSPSHSPLHSGPRPRRRE---SDPTGPQRQVF 664
Query: 360 RLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTG--------PRPSLRP 411
+A P + PR+ P E R+ + G P+ L P
Sbjct: 665 SVAPPFEVNGLPRAVPLSLPYQDFKRDLSDYRERARLLNRVRRVGFSHMLLTTPQVPLAP 724
Query: 412 LRLEV--KREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE 450
++ + K E +++EEEDEEEEEEEEEEE+EEEEE
Sbjct: 725 VQPQANGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEE 765
Score = 37.0 bits (84), Expect = 0.095
Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 1/68 (1%)
Query: 793 EDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHC-PYQSPPSKANRQLCSR 851
ED + EEEEEE EEEEE++EEE++ + + P S+ + + R
Sbjct: 740 EDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVALGEVLGPRSGSSSEGSERSTDR 799
Query: 852 SRSSSGSS 859
S+ + S+
Sbjct: 800 SQEGAPST 807
Score = 35.0 bits (79), Expect = 0.36
Identities = 15/18 (83%), Positives = 17/18 (94%)
Query: 807 EEEEEEGEEEEEDDEEED 824
EEEEEE EEEEE+DEEE+
Sbjct: 735 EEEEEEDEEEEEEDEEEE 752
Score = 33.9 bits (76), Expect = 0.81
Identities = 16/39 (41%), Positives = 23/39 (58%)
Query: 786 PEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
P+ + E+ E +EEEEE EEEEE++EEE+
Sbjct: 727 PQANGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEE 765
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 51.6 bits (122), Expect = 4e-06
Identities = 81/357 (22%), Positives = 124/357 (34%), Gaps = 68/357 (19%)
Query: 167 TSSSDTQKEGTAWRQAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTS-AQC 225
+SSS + ++ + S S D ++++ + S S E+ + +
Sbjct: 1035 SSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEV 1094
Query: 226 CLQDRGLQPPCLQSPRLPAKEDKEPGEDCPSPQPAPASPQDSLALGRADPGAPVSQEDMQ 285
+ +R P P A + G SP AP P + A P AP + D +
Sbjct: 1095 PVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEP----PAGPPAPAPRPDER 1150
Query: 286 AMVQL------------IRYMHTYCLPQRKLPPQTPE----PLP---KACSNPSQQVRSR 326
+ + + +P + PP TP P P KA + +R+
Sbjct: 1151 PSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNL 1210
Query: 327 PWSRHHSKASWAEFSIL--------RELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPP 378
P SW E R L ++ + LA +LTP R P
Sbjct: 1211 PLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPA 1270
Query: 379 ----KDSQAS----------PGRPSSVEEVRIAASPKSTGPRPSLRPLR----------- 413
+DS+A+ P + E A + K T P P+LRP
Sbjct: 1271 LPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSS 1330
Query: 414 -----------LEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRG 459
+ + E +P +LQQQ EE EEE EEE EEE+EE + G G
Sbjct: 1331 PADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEG 1387
Score = 40.0 bits (92), Expect = 0.011
Identities = 53/223 (23%), Positives = 85/223 (38%), Gaps = 41/223 (18%)
Query: 129 PAPSSAPPSPAP---EKPSAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWRQAGLR 185
P P + PP+PAP E+PS+P P + +K + ++ + T
Sbjct: 1134 PEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATP------- 1186
Query: 186 SKSQRPCVKADSTQDKKAPM-MQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSPRLPA 244
P K +KAP ++ R+ H L + RG + RL
Sbjct: 1187 -----PQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTE 1241
Query: 245 KEDKEPGED-----------CPSPQPAPASP--QDSLALGRADPGAPVSQEDMQAMVQLI 291
+E+ EPG + P+ + PA P +DS A +D E + ++ I
Sbjct: 1242 EEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSD-----EAERPRPLLSHI 1296
Query: 292 RYMHTYCLPQRKLPP----QTPEPLPKAC---SNPSQQVRSRP 327
H Y L + PP + PEP+P S+P+ +V P
Sbjct: 1297 LLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAP 1339
Score = 39.3 bits (90), Expect = 0.019
Identities = 44/185 (23%), Positives = 70/185 (37%), Gaps = 22/185 (11%)
Query: 713 EPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTL--LRDHEIRASLTKHFGL 770
EPS + ++ P A+ + ++ +AG P + T RD E + KH
Sbjct: 899 EPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKS 958
Query: 771 LETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEE---------EEEDDE 821
E E+ + ++SSS E +EE+E+ EE E D E
Sbjct: 959 FALDSEGEEAS-----------QESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGE 1007
Query: 822 EEDSGVSPTCSDHCPYQSPPSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCS 881
+E+S S CS + + S S SSS SS S S ++ + S
Sbjct: 1008 DEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEE 1067
Query: 882 DRTPS 886
+ P+
Sbjct: 1068 EERPA 1072
Score = 34.7 bits (78), Expect = 0.47
Identities = 25/85 (29%), Positives = 41/85 (48%), Gaps = 11/85 (12%)
Query: 374 RPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPL-RLEVKREVRRPARLQQQEEE 432
RPRP ++ P +E A P G +P R R + + + R+ L + EE
Sbjct: 911 RPRPSTPAEEDEDDPEQEKE---AGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEE 967
Query: 433 -------DEEEEEEEEEEEKEEEEE 450
+++EE++EE+EE E+ EE
Sbjct: 968 ASQESSSEKDEEDDEEDEEDEDREE 992
Score = 32.7 bits (73), Expect = 1.8
Identities = 48/221 (21%), Positives = 75/221 (33%), Gaps = 50/221 (22%)
Query: 131 PSSAPPSPAPEKPSA------PAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWRQAGL 184
P+S P P P +P P+PE +E+ + + + +T E + Q
Sbjct: 428 PASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQ--- 484
Query: 185 RSKSQRPCVKADSTQDKKAPMMQSQSRSC-------TELHKHLTSAQCCLQDRGLQPPCL 237
S+ D + M+ + RS TE + +S +D G + P
Sbjct: 485 -----------HSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVP-- 531
Query: 238 QSPRLPAKEDKEPGEDCPSPQPAPASPQDSLALGRADPGA----PVSQEDMQAM------ 287
G +P PAPA+ +D G +PGA P + QA
Sbjct: 532 ----------SGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGD 581
Query: 288 -VQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRP 327
+++ P PPQ P P P P + S P
Sbjct: 582 DMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLP 622
Score = 32.0 bits (71), Expect = 3.1
Identities = 15/22 (68%), Positives = 17/22 (77%)
Query: 807 EEEEEEGEEEEEDDEEEDSGVS 828
EE EEEGEEE E++EEE S S
Sbjct: 1359 EEGEEEGEEEGEEEEEESSDSS 1380
Score = 30.4 bits (67), Expect = 8.9
Identities = 25/72 (34%), Positives = 37/72 (51%), Gaps = 9/72 (12%)
Query: 396 IAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEE---EEEEEEKEEEEEWG 452
I A +G R +LR +VKR + P+ + + EE EE+E++ E+E+E G
Sbjct: 875 IEAFAFGSGLRGALRLPSFKVKR--KEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAG 932
Query: 453 RKRPGRGLPWTK 464
PGR P TK
Sbjct: 933 --EPGR--PGTK 940
>gi|24431935 reticulon 4 isoform A [Homo sapiens]
Length = 1192
Score = 51.2 bits (121), Expect = 5e-06
Identities = 80/297 (26%), Positives = 107/297 (36%), Gaps = 72/297 (24%)
Query: 427 QQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSRRLNPEL 486
+ ++EE+EEEEEEE+E+E EE E ++P GL S PV + P
Sbjct: 30 EPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGL-----------SAAPVPTA----PAA 74
Query: 487 GPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGPQIPALE 546
G L VP P+G LP+ AP + P+ S P A
Sbjct: 75 GAPLMDFGNDFVPPAPRGPLPA---APPVAPERQPSWDPSPVSSTVPAP---SPLSAAAV 128
Query: 547 SPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCGTAGLTP 606
SP S + DE P+ P PP S Q++P + TP
Sbjct: 129 SP--SKLPEDDEPPARPPPPPPAS------VSPQAEPVW-------------------TP 161
Query: 607 PTTPPYKPTEEDPFKPDIKHSLGK--EIALSLP---------SPEGLSLKATPGAAHKLP 655
P P P P P + S G E +LP S E + LK PG
Sbjct: 162 PAPAPAAP-PSTPAAPKRRGSSGSVDETLFALPAASEPVIRSSAENMDLKEQPGNTISAG 220
Query: 656 KKHPERSELLSHLRHATAQPASQAGQKRPFSCSFGDHDY----CQVLRPEGVLQRKV 708
++ L + + P S A SF +H+Y VL EG LQ V
Sbjct: 221 QEDFPSVLLETAASLPSLSPLSAA--------SFKEHEYLGNLSTVLPTEGTLQENV 269
Score = 33.1 bits (74), Expect = 1.4
Identities = 13/18 (72%), Positives = 17/18 (94%)
Query: 806 PEEEEEEGEEEEEDDEEE 823
PE+EEEE EEEEED++E+
Sbjct: 31 PEDEEEEEEEEEEDEDED 48
>gi|239745093 PREDICTED: hypothetical protein XP_002343359 [Homo
sapiens]
Length = 142
Score = 50.8 bits (120), Expect = 6e-06
Identities = 24/38 (63%), Positives = 32/38 (84%)
Query: 413 RLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE 450
R E +RE +R + +++EEE+EEEEEEEEEEE+EEEEE
Sbjct: 83 REEKRREGKRREKEEEKEEEEEEEEEEEEEEEEEEEEE 120
Score = 46.6 bits (109), Expect = 1e-04
Identities = 22/38 (57%), Positives = 31/38 (81%)
Query: 413 RLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE 450
R E +RE +R ++++EE++EEEEEEEEEE+EEEEE
Sbjct: 78 REEKRREEKRREGKRREKEEEKEEEEEEEEEEEEEEEE 115
Score = 46.6 bits (109), Expect = 1e-04
Identities = 22/38 (57%), Positives = 29/38 (76%)
Query: 413 RLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE 450
R E KR + ++++EE+EEEEEEEEEEE+EEEEE
Sbjct: 82 RREEKRREGKRREKEEEKEEEEEEEEEEEEEEEEEEEE 119
Score = 43.9 bits (102), Expect = 8e-04
Identities = 21/38 (55%), Positives = 29/38 (76%)
Query: 413 RLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE 450
R E KR + +++E+E+E+EEEEEEEEE+EEEEE
Sbjct: 77 RREEKRREEKRREGKRREKEEEKEEEEEEEEEEEEEEE 114
Score = 41.2 bits (95), Expect = 0.005
Identities = 32/88 (36%), Positives = 44/88 (50%), Gaps = 14/88 (15%)
Query: 375 PRPPKDSQASPGRPSSVEEVR-----IAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQ 429
P P + G +S V+ + S T R S R R E +RE +R +++
Sbjct: 27 PYPHSKRENLAGLTNSTSSVKEEPPTLRHSMAGTSARKSQR--REEKRREEKRREEKRRE 84
Query: 430 EE-------EDEEEEEEEEEEEKEEEEE 450
E+ E EEE+EEEEEEE+EEEEE
Sbjct: 85 EKRREGKRREKEEEKEEEEEEEEEEEEE 112
Score = 35.4 bits (80), Expect = 0.28
Identities = 16/22 (72%), Positives = 19/22 (86%)
Query: 807 EEEEEEGEEEEEDDEEEDSGVS 828
EEEEEE EEEEE++EEE+ VS
Sbjct: 101 EEEEEEEEEEEEEEEEEEEEVS 122
Score = 33.5 bits (75), Expect = 1.1
Identities = 15/22 (68%), Positives = 18/22 (81%)
Query: 807 EEEEEEGEEEEEDDEEEDSGVS 828
EEEEEE EEEEE++EEE+ S
Sbjct: 103 EEEEEEEEEEEEEEEEEEVSFS 124
Score = 33.1 bits (74), Expect = 1.4
Identities = 14/18 (77%), Positives = 17/18 (94%)
Query: 807 EEEEEEGEEEEEDDEEED 824
EEEEEE EEEEE++EEE+
Sbjct: 100 EEEEEEEEEEEEEEEEEE 117
Score = 31.6 bits (70), Expect = 4.0
Identities = 13/18 (72%), Positives = 17/18 (94%)
Query: 807 EEEEEEGEEEEEDDEEED 824
EEE+EE EEEEE++EEE+
Sbjct: 96 EEEKEEEEEEEEEEEEEE 113
Score = 31.6 bits (70), Expect = 4.0
Identities = 13/18 (72%), Positives = 17/18 (94%)
Query: 807 EEEEEEGEEEEEDDEEED 824
EE+EEE EEEEE++EEE+
Sbjct: 97 EEKEEEEEEEEEEEEEEE 114
Score = 31.6 bits (70), Expect = 4.0
Identities = 13/18 (72%), Positives = 17/18 (94%)
Query: 807 EEEEEEGEEEEEDDEEED 824
E+EEEE EEEEE++EEE+
Sbjct: 98 EKEEEEEEEEEEEEEEEE 115
Score = 31.6 bits (70), Expect = 4.0
Identities = 13/18 (72%), Positives = 17/18 (94%)
Query: 807 EEEEEEGEEEEEDDEEED 824
+EEEEE EEEEE++EEE+
Sbjct: 99 KEEEEEEEEEEEEEEEEE 116
Score = 31.2 bits (69), Expect = 5.2
Identities = 13/32 (40%), Positives = 20/32 (62%)
Query: 424 ARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKR 455
AR Q+ EE EE+ EE+ +EE+ G++R
Sbjct: 62 ARKSQRREEKRREEKRREEKRREEKRREGKRR 93
>gi|118600967 shroom family member 4 [Homo sapiens]
Length = 1493
Score = 50.1 bits (118), Expect = 1e-05
Identities = 26/56 (46%), Positives = 36/56 (64%)
Query: 395 RIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE 450
R A P P P+ RL + ++ + QQ+++E+EEEEEEEEEEE+EEEEE
Sbjct: 1095 RKKAFPPPRPPPPNWEKYRLFRAAQQQKQQQQQQKQQEEEEEEEEEEEEEEEEEEE 1150
Score = 33.5 bits (75), Expect = 1.1
Identities = 14/19 (73%), Positives = 18/19 (94%)
Query: 807 EEEEEEGEEEEEDDEEEDS 825
EEEEEE EEEEE++EEE++
Sbjct: 1134 EEEEEEEEEEEEEEEEEEA 1152
Score = 33.5 bits (75), Expect = 1.1
Identities = 15/23 (65%), Positives = 18/23 (78%)
Query: 807 EEEEEEGEEEEEDDEEEDSGVSP 829
EEEEEE EEEEE+ EEE+ + P
Sbjct: 1139 EEEEEEEEEEEEEAEEEEEELPP 1161
Score = 33.1 bits (74), Expect = 1.4
Identities = 14/18 (77%), Positives = 17/18 (94%)
Query: 807 EEEEEEGEEEEEDDEEED 824
EEEEEE EEEEE++EEE+
Sbjct: 1132 EEEEEEEEEEEEEEEEEE 1149
Score = 33.1 bits (74), Expect = 1.4
Identities = 14/18 (77%), Positives = 17/18 (94%)
Query: 807 EEEEEEGEEEEEDDEEED 824
EEEEEE EEEEE++EEE+
Sbjct: 1133 EEEEEEEEEEEEEEEEEE 1150
Score = 32.3 bits (72), Expect = 2.3
Identities = 15/32 (46%), Positives = 21/32 (65%)
Query: 807 EEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQ 838
+EEEEE EEEEE++EEE+ + + P Q
Sbjct: 1131 QEEEEEEEEEEEEEEEEEEEEAEEEEEELPPQ 1162
Score = 30.8 bits (68), Expect = 6.8
Identities = 12/18 (66%), Positives = 17/18 (94%)
Query: 807 EEEEEEGEEEEEDDEEED 824
++EEEE EEEEE++EEE+
Sbjct: 1130 QQEEEEEEEEEEEEEEEE 1147
>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 1 [Homo sapiens]
Length = 1099
Score = 50.1 bits (118), Expect = 1e-05
Identities = 24/42 (57%), Positives = 32/42 (76%), Gaps = 1/42 (2%)
Query: 427 QQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRK 468
++QEEE+EEEE+EEEEEE+EEEEE G + P L W + +K
Sbjct: 867 EEQEEEEEEEEQEEEEEEEEEEEEKGNEEP-LSLDWPETRQK 907
Score = 43.9 bits (102), Expect = 8e-04
Identities = 19/33 (57%), Positives = 27/33 (81%)
Query: 427 QQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRG 459
+++EEE+EE+EEEEEEEE+EEEEE + +G
Sbjct: 860 EEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKG 892
Score = 43.5 bits (101), Expect = 0.001
Identities = 19/35 (54%), Positives = 27/35 (77%)
Query: 427 QQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLP 461
+++EEE++EEEEEEEE+E+EEEEE + G P
Sbjct: 862 EEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEP 896
Score = 39.3 bits (90), Expect = 0.019
Identities = 18/35 (51%), Positives = 24/35 (68%)
Query: 415 EVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEE 449
E + E +++EE++EEEEEEEEEEEK EE
Sbjct: 861 EEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEE 895
Score = 38.5 bits (88), Expect = 0.033
Identities = 18/36 (50%), Positives = 24/36 (66%)
Query: 415 EVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE 450
E + E +++EEE EEEEEEEEEEE++ EE
Sbjct: 860 EEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEE 895
Score = 38.1 bits (87), Expect = 0.043
Identities = 18/32 (56%), Positives = 22/32 (68%)
Query: 793 EDSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
ED S G S EEEEEE EEEEE++E+E+
Sbjct: 849 EDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEE 880
Score = 37.0 bits (84), Expect = 0.095
Identities = 15/21 (71%), Positives = 20/21 (95%)
Query: 430 EEEDEEEEEEEEEEEKEEEEE 450
+ E+EEEEEEE+EEE+EEEE+
Sbjct: 858 DSEEEEEEEEEQEEEEEEEEQ 878
Score = 35.4 bits (80), Expect = 0.28
Identities = 20/50 (40%), Positives = 29/50 (58%), Gaps = 1/50 (2%)
Query: 775 LEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
L E+ K+ E V + S G+S EEEEE+ EEEEE+++EE+
Sbjct: 833 LSAENHGEAKNDEKG-VEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEE 881
Score = 34.7 bits (78), Expect = 0.47
Identities = 16/31 (51%), Positives = 20/31 (64%)
Query: 794 DSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
DS E EEEEEE +EEEE++EEE+
Sbjct: 858 DSEEEEEEEEEQEEEEEEEEQEEEEEEEEEE 888
Score = 34.7 bits (78), Expect = 0.47
Identities = 17/41 (41%), Positives = 21/41 (51%)
Query: 793 EDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSD 833
E+ E EEEE+E EEEEE++EEE P D
Sbjct: 860 EEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEPLSLD 900
Score = 33.1 bits (74), Expect = 1.4
Identities = 15/31 (48%), Positives = 20/31 (64%)
Query: 794 DSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
D S E E+EEEE EEE+E++EEE+
Sbjct: 855 DGGDSEEEEEEEEEQEEEEEEEEQEEEEEEE 885
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 49.7 bits (117), Expect = 1e-05
Identities = 33/95 (34%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 387 RPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKE 446
R +E R K R + E +++ +R + +++EEE EEEEEEEEEE++E
Sbjct: 29 RKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEE 88
Query: 447 EEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSRR 481
EE+E GR+R + K RK E +R R+
Sbjct: 89 EEKEEGRRRKKK----KKRRRKEEEEEKKKKRRRK 119
Score = 45.1 bits (105), Expect = 3e-04
Identities = 27/89 (30%), Positives = 42/89 (47%)
Query: 370 TPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQ 429
T + K+ + R +E K T R + KR+ ++ +++
Sbjct: 16 TEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEER 75
Query: 430 EEEDEEEEEEEEEEEKEEEEEWGRKRPGR 458
EEE+EEEEEE+EEEEKEE +K+ R
Sbjct: 76 EEEEEEEEEEKEEEEKEEGRRRKKKKKRR 104
Score = 32.3 bits (72), Expect = 2.3
Identities = 15/34 (44%), Positives = 23/34 (67%)
Query: 421 RRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRK 454
++ + +++ EE EE EE EEEEEKE + + RK
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRK 34
Score = 32.3 bits (72), Expect = 2.3
Identities = 27/113 (23%), Positives = 45/113 (39%), Gaps = 18/113 (15%)
Query: 387 RPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEE-------- 438
+ EE + + R + + KR+ + + ++ E+ +E+EE
Sbjct: 6 KKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRK 65
Query: 439 ----------EEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSRR 481
EEEEEE+EEE+E K GR K R+ E ++ RR
Sbjct: 66 RKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRR 118
Score = 32.0 bits (71), Expect = 3.1
Identities = 16/65 (24%), Positives = 35/65 (53%)
Query: 417 KREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPV 476
K++ ++ ++ EE +E EEEEE+E +++E+ + RK + + ++ E
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60
Query: 477 RRSRR 481
+R R+
Sbjct: 61 KRKRK 65
Score = 30.8 bits (68), Expect = 6.8
Identities = 21/88 (23%), Positives = 40/88 (45%), Gaps = 4/88 (4%)
Query: 372 RSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEE 431
R R K + + + E R + + + + E +RE +++EE
Sbjct: 29 RKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEE 88
Query: 432 EDEEE----EEEEEEEEKEEEEEWGRKR 455
E++EE +++++ KEEEEE +KR
Sbjct: 89 EEKEEGRRRKKKKKRRRKEEEEEKKKKR 116
Score = 30.4 bits (67), Expect = 8.9
Identities = 12/19 (63%), Positives = 17/19 (89%)
Query: 808 EEEEEGEEEEEDDEEEDSG 826
EEEEE EEEE+++EE++ G
Sbjct: 76 EEEEEEEEEEKEEEEKEEG 94
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 49.3 bits (116), Expect = 2e-05
Identities = 86/408 (21%), Positives = 160/408 (39%), Gaps = 60/408 (14%)
Query: 60 ELQWCPENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGG 119
E Q E +E E + ++ + + E EA E ++ AA P +
Sbjct: 463 ETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE-----EETKSPPAEEAASPEKEAK 517
Query: 120 DALSCTSASPAPSSAPP-----SPA----PEKPSAPAPEVDELSLLQKLLLATSYPTSSS 170
+ + SPA + +P SPA PEK +PA E A S P + S
Sbjct: 518 SPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE-----------AKSPPEAKS 566
Query: 171 DTQKEGTAWRQAGLRSKSQRPCVK-ADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQD 229
++E + + K++ P + A S + K+P + E K A+ +++
Sbjct: 567 PEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSP--EKAKSPVKEEAKSPAEAKSPVKE 624
Query: 230 RGLQPPCLQSP---RLPAKEDKEPGEDCPSPQPAPA-SPQDSLALGRADPGAPVSQEDMQ 285
P ++SP + P KE+ + E SP+ A SP+ + + +A+ +P E +
Sbjct: 625 EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSP---EKAK 681
Query: 286 AMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQ---VRSRPWSRHHSKASWAEFSI 342
+ V+ + K P + P+ + +P + V+ S +K+ E +
Sbjct: 682 SPVKA----------EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK 731
Query: 343 LRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKS 402
E V + P + +P A D ++ + + EE R SP
Sbjct: 732 TPEKAKSPVKEEAKSPEKAKSPEKAKTL---------DVKSPEAKTPAKEEAR---SPAD 779
Query: 403 TGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE 450
P + P++ EVK + + L++ + E+E ++EE + +EE
Sbjct: 780 KFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEE 827
Score = 48.5 bits (114), Expect = 3e-05
Identities = 97/470 (20%), Positives = 179/470 (38%), Gaps = 57/470 (12%)
Query: 128 SPAPSSAPP---SPAPEKPSAPA----PEVDELSLLQKLLLATSYPTSSSDTQKEGTAWR 180
SPA +P SPA E+ +PA PE + + ++ A S + S ++E +
Sbjct: 574 SPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEE---AKSPAEAKSPVKEEAKSPA 630
Query: 181 QAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSP 240
+ K++ P K ++ +KA + + E K A+ ++ P ++
Sbjct: 631 EVKSPEKAKSP-TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEA- 688
Query: 241 RLPAKEDKEPGEDCPSPQPAPASPQDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLP 300
+ P K E+ SP+ A SP A +PV +E P
Sbjct: 689 KSPEKAKSPVKEEAKSPEKAK-SPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP 747
Query: 301 QRKLPPQTPEPL----PKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDVS 356
++ P+ + L P+A + ++ RS P + KA S ++E +V
Sbjct: 748 EKAKSPEKAKTLDVKSPEAKTPAKEEARS-PADKFPEKAK----SPVKE--------EVK 794
Query: 357 KPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSV-EEVRIAASPKSTGPRPSLRPLRLE 415
P + +P+ + P K+ SP + +EV++ PK + + E
Sbjct: 795 SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE 854
Query: 416 VKREVRR---------PARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLG 466
K++ ++ ++++++E E+ +E + E K+EE E +K P P +
Sbjct: 855 EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVP---TPEKEAP 911
Query: 467 RKLESSVCPVRRSRRLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPT 526
K+E + + + P A EP P+E + A AP+ D + E
Sbjct: 912 AKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEA------APEKKDTKEEKAKKP 965
Query: 527 DED-------SGQDQQLLRGPQIPALESPCESGCGDMDEDPSCPQLPPRD 569
+E D+ L + P P E +S D +D P+ D
Sbjct: 966 EEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTD-QKDSKPPEKATED 1014
Score = 38.9 bits (89), Expect = 0.025
Identities = 96/518 (18%), Positives = 184/518 (35%), Gaps = 60/518 (11%)
Query: 377 PPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKR--EVRRPARLQQQEEEDE 434
PP + ASP + E + ++ P + P + E K EV+ P + + +E+
Sbjct: 504 PPAEEAASPEK-----EAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 558
Query: 435 EEEEEEEEEEKEEEEEWGR-KRPGRGLPWTKLGRKLESSVCPVRRSRRLNPELGPWLTFA 493
+ E + EKEE + K P + K K + +++
Sbjct: 559 KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKS---------PVK 609
Query: 494 DEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGPQIPALESP----- 548
+E P+E + + +P + SPT E++ ++ + P+ +SP
Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKA-KSPEKEEAKSPEKAKS 668
Query: 549 ---CESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCGTAGLT 605
E+ + + P + + + + ++S E+ + E +
Sbjct: 669 PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728
Query: 606 PPTTPPY--KPTEEDPFKPDIKHSLGKEIALSLPSPEGLS--LKATPGAAHKLPKK---- 657
TP P +E+ P+ S K L + SPE + + A K P+K
Sbjct: 729 EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSP 788
Query: 658 ------HPERSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLR----PEGVLQRK 707
PE+++ S L+ P + +K + + Q ++ P+ + K
Sbjct: 789 VKEEVKSPEKAK--SPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEK 846
Query: 708 VLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTK- 766
+ P +D ++ AP EA P EE + A PK+S + E K
Sbjct: 847 APAT--PKTEEKKDSKKEEAPKKEAPKPKVEEKKE-PAVEKPKESKVEAKKEEAEDKKKV 903
Query: 767 ---------HFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEE 817
+ E A +E K D ++ S + + PE+++ + EE+
Sbjct: 904 PTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTK-EEKA 962
Query: 818 EDDEEEDSGVSPTCSDHCPYQSPPSKANRQLCSRSRSS 855
+ EE+ + D PSK + +S S+
Sbjct: 963 KKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSST 1000
Score = 38.1 bits (87), Expect = 0.043
Identities = 34/146 (23%), Positives = 62/146 (42%), Gaps = 4/146 (2%)
Query: 416 VKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCP 475
V++ + +++Q EE + EE EEEEKE +EE G++ G G G + E+ P
Sbjct: 447 VEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEG-GEEEEAEGGEEETKSPP 505
Query: 476 VRRSRRLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQ 535
+ +PE +E P+E + +P + SP E++ +
Sbjct: 506 AEEA--ASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPE 563
Query: 536 LLRGPQIPALESPCESGCGDMDEDPS 561
+ P+ +SP E + + P+
Sbjct: 564 -AKSPEKEEAKSPAEVKSPEKAKSPA 588
Score = 32.0 bits (71), Expect = 3.1
Identities = 37/177 (20%), Positives = 68/177 (38%), Gaps = 7/177 (3%)
Query: 724 QQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASC 783
+ +P EA++P +EE +S P+ E+++ E A +
Sbjct: 508 EAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPE---A 564
Query: 784 KSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSPPSK 843
KSPE + + S E + P +EE + E + E+ S V +SP +
Sbjct: 565 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624
Query: 844 ANRQLCSRSRSSSGSSPC--HSWSPATRRN-FRCESRGPCSDRTPSIRHARKRREKA 897
+ SP + SP ++ + E++ P ++P ++ K EKA
Sbjct: 625 EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSP-VKAEAKSPEKA 680
Score = 31.6 bits (70), Expect = 4.0
Identities = 38/174 (21%), Positives = 67/174 (38%), Gaps = 20/174 (11%)
Query: 739 EDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDSSSS 798
E C G P +L S++ H ++ EE+ KS + + E+ +
Sbjct: 407 EGEECRIGFGPIPFSLPEGLPKIPSVSTH---IKVKSEEKIKVVEKSEKETVIVEEQTEE 463
Query: 799 SGESSFLPEEEEEE-----------GEEEEEDDEEEDSGVSPTCSDHCPYQSPPSKANRQ 847
+ + + EEEE+E GEEEE + EE++ P P + S +
Sbjct: 464 TQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEE 523
Query: 848 LCSRSRSSS-----GSSPCHSWSPATRRN-FRCESRGPCSDRTPSIRHARKRRE 895
S + + S SP SP ++ + E++ P ++P A+ E
Sbjct: 524 AKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAE 577
>gi|148762982 hypothetical protein LOC387640 [Homo sapiens]
Length = 908
Score = 48.9 bits (115), Expect = 2e-05
Identities = 40/104 (38%), Positives = 48/104 (46%), Gaps = 18/104 (17%)
Query: 782 SCKSPEYDTVFED---------SSSSSGESSFLPEEEEEEGEEEEEDDEEE-DSGVSPTC 831
SC S + + D SS SS +S EEEEEEGEEEEE++EEE SG S +
Sbjct: 378 SCSSDSESSSYSDHAANDSDFGSSLSSSSNSVSSEEEEEEGEEEEEEEEEEGGSGASDS- 436
Query: 832 SDHCPYQSPPSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCE 875
S S + S SSSGSS S RR C+
Sbjct: 437 -------SEVSSEEEDSSTESDSSSGSSQVSVQSIRFRRTSFCK 473
Score = 34.7 bits (78), Expect = 0.47
Identities = 16/19 (84%), Positives = 17/19 (89%)
Query: 434 EEEEEEEEEEEKEEEEEWG 452
EEEEEE EEEE+EEEEE G
Sbjct: 412 EEEEEEGEEEEEEEEEEGG 430
Score = 32.0 bits (71), Expect = 3.1
Identities = 14/17 (82%), Positives = 16/17 (94%)
Query: 430 EEEDEEEEEEEEEEEKE 446
EEE+EE EEEEEEEE+E
Sbjct: 412 EEEEEEGEEEEEEEEEE 428
Score = 32.0 bits (71), Expect = 3.1
Identities = 14/17 (82%), Positives = 16/17 (94%)
Query: 431 EEDEEEEEEEEEEEKEE 447
EE+EEE EEEEEEE+EE
Sbjct: 412 EEEEEEGEEEEEEEEEE 428
Score = 32.0 bits (71), Expect = 3.1
Identities = 14/17 (82%), Positives = 16/17 (94%)
Query: 432 EDEEEEEEEEEEEKEEE 448
E+EEEE EEEEEE+EEE
Sbjct: 412 EEEEEEGEEEEEEEEEE 428
Score = 32.0 bits (71), Expect = 3.1
Identities = 14/17 (82%), Positives = 16/17 (94%)
Query: 433 DEEEEEEEEEEEKEEEE 449
+EEEEE EEEEE+EEEE
Sbjct: 412 EEEEEEGEEEEEEEEEE 428
Score = 31.6 bits (70), Expect = 4.0
Identities = 13/17 (76%), Positives = 16/17 (94%)
Query: 427 QQQEEEDEEEEEEEEEE 443
+++EEE EEEEEEEEEE
Sbjct: 412 EEEEEEGEEEEEEEEEE 428
Score = 31.2 bits (69), Expect = 5.2
Identities = 13/20 (65%), Positives = 17/20 (85%)
Query: 426 LQQQEEEDEEEEEEEEEEEK 445
+ +EEE+E EEEEEEEEE+
Sbjct: 409 VSSEEEEEEGEEEEEEEEEE 428
Score = 30.8 bits (68), Expect = 6.8
Identities = 28/89 (31%), Positives = 37/89 (41%), Gaps = 5/89 (5%)
Query: 789 DTVFEDSSSSSGESSFLPEEEEE-----EGEEEEEDDEEEDSGVSPTCSDHCPYQSPPSK 843
D+ F S SSS S EEEEE E EEEE DS + + +S S
Sbjct: 395 DSDFGSSLSSSSNSVSSEEEEEEGEEEEEEEEEEGGSGASDSSEVSSEEEDSSTESDSSS 454
Query: 844 ANRQLCSRSRSSSGSSPCHSWSPATRRNF 872
+ Q+ +S +S C S + NF
Sbjct: 455 GSSQVSVQSIRFRRTSFCKPPSVQAQANF 483
>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
sapiens]
Length = 1251
Score = 48.5 bits (114), Expect = 3e-05
Identities = 59/220 (26%), Positives = 93/220 (42%), Gaps = 42/220 (19%)
Query: 257 PQPAPASP----QDSLALGRA-DPGAPVSQEDMQAMVQLIRYMHTYCLPQ------RKLP 305
PQP +S + ++A G A DP P ++M +Q T LP ++ P
Sbjct: 171 PQPPKSSEVWRDEPAVATGAASDPAPPGRPQEMGPKLQA---RETPSLPTPIPLQPKEEP 227
Query: 306 PQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVL------------- 352
+ P P P+ S Q S P +R ++ L L Q VL
Sbjct: 228 KEAPAPEPQPGSQA--QTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPG 285
Query: 353 -CDVSKPYRLATPVYASLTPRSRPRPPKD-SQASPGRPSSVEEVRIAASPKSTGPRPSLR 410
CDV S+ P + P + P + ++V + SP+ T P+
Sbjct: 286 ICDVQT---------ISILPGGQVEPDLVLEEVEPPWEDAHQDV--STSPQGTEVVPAYE 334
Query: 411 PLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE 450
V++ R +R+++++E++EEEEEEEEEEE+EE E
Sbjct: 335 EENKAVEKMPRELSRIEEEKEDEEEEEEEEEEEEEEEVTE 374
Score = 42.4 bits (98), Expect = 0.002
Identities = 96/431 (22%), Positives = 144/431 (33%), Gaps = 84/431 (19%)
Query: 423 PARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSRRL 482
P + + QEEE+ E E E E E + E + +P + ++ E +V
Sbjct: 16 PRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFKEEEVAVADPSPQETK 75
Query: 483 NPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGPQI 542
L ++ + SE + L VE+ + P + Q+L
Sbjct: 76 EAALTSTISLRAQGAEISEMNSPSRRV-LTWLMKGVEKVIPQPVHSITEDPAQIL----- 129
Query: 543 PALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQS------DPTFGKKSFEQTLTV 596
S ++GC D + + + R R L+L L Q+ P + + V
Sbjct: 130 -GHGSTGDTGCTD-EPNEALEAQDTRPGLR-LLLWLEQNLERVLPQPPKSSEVWRDEPAV 186
Query: 597 ELCGTAGLTPPTTP----PYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAH 652
+ PP P P E P P KE P+PE PG+
Sbjct: 187 ATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPE-----PQPGSQA 241
Query: 653 KLPKKHPERSE------LLSHLRHATAQPA--SQAGQKRPFSCSFGDHDYCQVLRPEGVL 704
+ P R +L L A QP + G++ P S D +L V
Sbjct: 242 QTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQVE 301
Query: 705 QRKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASL 764
VL EP PW ED D P+ + ++
Sbjct: 302 PDLVLEEVEP-------------PW---------EDAHQDVSTSPQGTEVV--------- 330
Query: 765 TKHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
A EEE+ A K P E S + EE+E+E EEEEE++EEE+
Sbjct: 331 --------PAYEEENKAVEKMPR-------------ELSRIEEEKEDEEEEEEEEEEEEE 369
Query: 825 SGVSPTCSDHC 835
V+ D C
Sbjct: 370 EEVTEVLLDSC 380
Score = 33.9 bits (76), Expect = 0.81
Identities = 32/152 (21%), Positives = 61/152 (40%), Gaps = 18/152 (11%)
Query: 400 PKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEE-EEKEEEEEWGRKRPGR 458
P+ST + + E K+E A+ + +E +EE E+E ++ E +EE E +
Sbjct: 397 PQSTSDQKLWEEVGEEAKKEAEEKAKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASS 456
Query: 459 GLPWTKLGRKL-----ESSVCPVRRSRRLNPELGPWLTFADEPLVPSEPQGALPSLCLAP 513
G+P TK ++ ++ CP+ NP V P A + P
Sbjct: 457 GVPATKQHPEVQVEDTDADSCPLMAEE--NP----------PSTVLPPPSPAKSDTLIVP 504
Query: 514 KAYDVERELGSPTDEDSGQDQQLLRGPQIPAL 545
+ P+++D ++ + L + P +
Sbjct: 505 SSASGTHRKKLPSEDDEAEELKALSPAESPVV 536
Score = 31.2 bits (69), Expect = 5.2
Identities = 44/214 (20%), Positives = 82/214 (38%), Gaps = 39/214 (18%)
Query: 66 ENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGDALSCT 125
E +E EP ++ E + ++E + TK ++ +D + P + + S
Sbjct: 431 EEAEKEPQDWAETKEEP-EAEAEAASSGVPATKQHPEVQVEDTDADSCPLMAEENPPSTV 489
Query: 126 SASPAPSSAPPSPAPEKPSAP-----------APEVDELSLLQKLLLATSYPTSSSDTQK 174
P+P+ + P S A E+ LS + ++A S PT+ DT
Sbjct: 490 LPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSDPTTPKDTDG 549
Query: 175 EGTAWRQAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQP 234
+ +A ST + ++ + + +L K T ++++ + P
Sbjct: 550 QD-----------------RAASTASTNSAIINDRLQELVKLFKERTEK---VKEKLIDP 589
Query: 235 PCL---QSPR-LPAKEDKEPGEDCPSPQPAPASP 264
+SP+ PAK+ EP P +PA A P
Sbjct: 590 DVTSDEESPKPSPAKKAPEP---APDTKPAEAEP 620
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 48.5 bits (114), Expect = 3e-05
Identities = 25/74 (33%), Positives = 43/74 (58%), Gaps = 1/74 (1%)
Query: 387 RPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEE-DEEEEEEEEEEEK 445
R S ++ + + +S + R ++++ + +++EEE +EEEEEEEEEEE+
Sbjct: 1365 RTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEE 1424
Query: 446 EEEEEWGRKRPGRG 459
EE+E K PG+G
Sbjct: 1425 EEDENDDSKSPGKG 1438
Score = 40.8 bits (94), Expect = 0.007
Identities = 20/41 (48%), Positives = 26/41 (63%)
Query: 789 DTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSP 829
D+ E+ S+S E EEEEEE EEEEE+++E D SP
Sbjct: 1395 DSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSP 1435
Score = 39.7 bits (91), Expect = 0.015
Identities = 20/34 (58%), Positives = 26/34 (76%)
Query: 791 VFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
V EDSSS + +S EEE+EE EEEEE++EEE+
Sbjct: 1392 VQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEE 1425
Score = 35.8 bits (81), Expect = 0.21
Identities = 17/47 (36%), Positives = 31/47 (65%)
Query: 427 QQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSV 473
+++EEE+EEEEEEE+E + + GRK+ + L KL + ++++
Sbjct: 1413 EEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNAL 1459
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 48.5 bits (114), Expect = 3e-05
Identities = 25/74 (33%), Positives = 43/74 (58%), Gaps = 1/74 (1%)
Query: 387 RPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEE-DEEEEEEEEEEEK 445
R S ++ + + +S + R ++++ + +++EEE +EEEEEEEEEEE+
Sbjct: 1403 RTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEE 1462
Query: 446 EEEEEWGRKRPGRG 459
EE+E K PG+G
Sbjct: 1463 EEDENDDSKSPGKG 1476
Score = 40.8 bits (94), Expect = 0.007
Identities = 20/41 (48%), Positives = 26/41 (63%)
Query: 789 DTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSP 829
D+ E+ S+S E EEEEEE EEEEE+++E D SP
Sbjct: 1433 DSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSP 1473
Score = 39.7 bits (91), Expect = 0.015
Identities = 20/34 (58%), Positives = 26/34 (76%)
Query: 791 VFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
V EDSSS + +S EEE+EE EEEEE++EEE+
Sbjct: 1430 VQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEE 1463
Score = 35.8 bits (81), Expect = 0.21
Identities = 17/47 (36%), Positives = 31/47 (65%)
Query: 427 QQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSV 473
+++EEE+EEEEEEE+E + + GRK+ + L KL + ++++
Sbjct: 1451 EEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNAL 1497
>gi|215490093 ATPase, (Na+)/K+ transporting, beta 4 polypeptide
isoform A [Homo sapiens]
Length = 357
Score = 48.5 bits (114), Expect = 3e-05
Identities = 30/64 (46%), Positives = 37/64 (57%), Gaps = 2/64 (3%)
Query: 415 EVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVC 474
E + E R + +EEE+EEE+EEEEEEEKEEEE G+ +P W KL E
Sbjct: 38 EAEEEARVTVVPKSEEEEEEEEKEEEEEEEKEEEE--GQGQPTGNAWWQKLQIMSEYLWD 95
Query: 475 PVRR 478
P RR
Sbjct: 96 PERR 99
Score = 33.9 bits (76), Expect = 0.81
Identities = 14/20 (70%), Positives = 18/20 (90%)
Query: 807 EEEEEEGEEEEEDDEEEDSG 826
EEEEEE EEEEE+++EE+ G
Sbjct: 54 EEEEEEKEEEEEEEKEEEEG 73
Score = 33.5 bits (75), Expect = 1.1
Identities = 13/32 (40%), Positives = 22/32 (68%)
Query: 793 EDSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
E+ + + +P+ EEEE EEE+E++EEE+
Sbjct: 36 EEEAEEEARVTVVPKSEEEEEEEEKEEEEEEE 67
Score = 33.1 bits (74), Expect = 1.4
Identities = 15/24 (62%), Positives = 18/24 (75%)
Query: 807 EEEEEEGEEEEEDDEEEDSGVSPT 830
EEEEE+ EEEEE+ EEE+ PT
Sbjct: 55 EEEEEKEEEEEEEKEEEEGQGQPT 78
>gi|6912256 ATPase, (Na+)/K+ transporting, beta 4 polypeptide
isoform B [Homo sapiens]
Length = 353
Score = 48.5 bits (114), Expect = 3e-05
Identities = 30/64 (46%), Positives = 37/64 (57%), Gaps = 2/64 (3%)
Query: 415 EVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVC 474
E + E R + +EEE+EEE+EEEEEEEKEEEE G+ +P W KL E
Sbjct: 38 EAEEEARVTVVPKSEEEEEEEEKEEEEEEEKEEEE--GQGQPTGNAWWQKLQIMSEYLWD 95
Query: 475 PVRR 478
P RR
Sbjct: 96 PERR 99
Score = 33.9 bits (76), Expect = 0.81
Identities = 14/20 (70%), Positives = 18/20 (90%)
Query: 807 EEEEEEGEEEEEDDEEEDSG 826
EEEEEE EEEEE+++EE+ G
Sbjct: 54 EEEEEEKEEEEEEEKEEEEG 73
Score = 33.5 bits (75), Expect = 1.1
Identities = 13/32 (40%), Positives = 22/32 (68%)
Query: 793 EDSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
E+ + + +P+ EEEE EEE+E++EEE+
Sbjct: 36 EEEAEEEARVTVVPKSEEEEEEEEKEEEEEEE 67
Score = 33.1 bits (74), Expect = 1.4
Identities = 15/24 (62%), Positives = 18/24 (75%)
Query: 807 EEEEEEGEEEEEDDEEEDSGVSPT 830
EEEEE+ EEEEE+ EEE+ PT
Sbjct: 55 EEEEEKEEEEEEEKEEEEGQGQPT 78
>gi|17975763 myelin transcription factor 1 [Homo sapiens]
Length = 1121
Score = 48.1 bits (113), Expect = 4e-05
Identities = 28/63 (44%), Positives = 39/63 (61%), Gaps = 3/63 (4%)
Query: 388 PSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEE 447
P S+E+ AAS +S+ + L + + E + +EEE+EEEEEEEEEEE+EE
Sbjct: 237 PQSLED---AASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEE 293
Query: 448 EEE 450
EEE
Sbjct: 294 EEE 296
Score = 45.4 bits (106), Expect = 3e-04
Identities = 21/36 (58%), Positives = 27/36 (75%)
Query: 415 EVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE 450
E + E +++EEE+EEEEEEEEEEE+EEEEE
Sbjct: 266 EEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEE 301
Score = 45.1 bits (105), Expect = 3e-04
Identities = 21/36 (58%), Positives = 27/36 (75%)
Query: 415 EVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE 450
E + E +++EEE+EEEEEEEEEEE+EEEEE
Sbjct: 265 EEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEE 300
Score = 45.1 bits (105), Expect = 3e-04
Identities = 21/36 (58%), Positives = 27/36 (75%)
Query: 415 EVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE 450
E + E +++EEE+EEEEEEEEEEE+EEEEE
Sbjct: 269 EEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE 304
Score = 44.7 bits (104), Expect = 5e-04
Identities = 19/24 (79%), Positives = 24/24 (100%)
Query: 427 QQQEEEDEEEEEEEEEEEKEEEEE 450
+++EEE+EEEEEEEEEEE+EEEEE
Sbjct: 282 EEEEEEEEEEEEEEEEEEEEEEEE 305
Score = 44.7 bits (104), Expect = 5e-04
Identities = 19/24 (79%), Positives = 24/24 (100%)
Query: 427 QQQEEEDEEEEEEEEEEEKEEEEE 450
+++EEE+EEEEEEEEEEE+EEEEE
Sbjct: 283 EEEEEEEEEEEEEEEEEEEEEEEE 306
Score = 42.7 bits (99), Expect = 0.002
Identities = 31/101 (30%), Positives = 44/101 (43%), Gaps = 8/101 (7%)
Query: 765 TKHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
+K G+L E+E+ + E + ED E EEEEEE EEEEE++EEE+
Sbjct: 249 SKQKGILSHEEEDEE----EEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE 304
Query: 825 SGVSPTCSDHCPYQSPPSKANRQLCSRSRSSSGSSPCHSWS 865
+P +Q S + Q R SP +S
Sbjct: 305 EEAAPDVI----FQEDTSHTSAQKAPELRGPESPSPKPEYS 341
Score = 41.2 bits (95), Expect = 0.005
Identities = 19/34 (55%), Positives = 25/34 (73%)
Query: 415 EVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEE 448
E + E +++EEE+EEEEEEEEEEE+EEE
Sbjct: 273 EDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE 306
Score = 39.3 bits (90), Expect = 0.019
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 773 TALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
T +DL C D E+SS G S E+EEEE EEEEE+++EE+
Sbjct: 228 TTERSQDL--CPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEE 277
Score = 37.0 bits (84), Expect = 0.095
Identities = 19/47 (40%), Positives = 26/47 (55%)
Query: 778 EDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
ED AS +S + + E EEEE+E EEEEE++EEE+
Sbjct: 241 EDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEE 287
Score = 36.2 bits (82), Expect = 0.16
Identities = 21/54 (38%), Positives = 27/54 (50%)
Query: 771 LETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
LE A EE ++ E+ E EEEEEE EEEEE++EEE+
Sbjct: 240 LEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEE 293
Score = 36.2 bits (82), Expect = 0.16
Identities = 18/53 (33%), Positives = 30/53 (56%)
Query: 772 ETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
E + +++ + S + + + E+ E EEEEEE EEEEE++EEE+
Sbjct: 246 EESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEE 298
>gi|11119430 testis-specific kinase substrate [Homo sapiens]
Length = 592
Score = 48.1 bits (113), Expect = 4e-05
Identities = 35/100 (35%), Positives = 49/100 (49%), Gaps = 22/100 (22%)
Query: 409 LRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRK 468
LR L+ +++ E R +QE E +E EE++E EEK+E EE +++P GL W LG
Sbjct: 224 LRYLQQQLQDETPR-----RQEAELQEPEEKQEPEEKQEPEE--KQKPEAGLSWNSLGPA 276
Query: 469 LESSVCPVRRSRRLNPELGPWLTFADEPLVPSEPQGALPS 508
S CP GP P PS P G +P+
Sbjct: 277 ATSQGCP-----------GP----PGSPDKPSRPHGLVPA 301
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 47.8 bits (112), Expect = 5e-05
Identities = 28/62 (45%), Positives = 37/62 (59%), Gaps = 4/62 (6%)
Query: 427 QQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPW----TKLGRKLESSVCPVRRSRRL 482
+++EEE+EEEEEEEEEEE+EE+EE G + G K RK V P R+ R+
Sbjct: 303 EEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRKR 362
Query: 483 NP 484
P
Sbjct: 363 EP 364
Score = 45.8 bits (107), Expect = 2e-04
Identities = 20/26 (76%), Positives = 25/26 (96%)
Query: 425 RLQQQEEEDEEEEEEEEEEEKEEEEE 450
+L ++EEE+EEEEEEEEEEE+EEEEE
Sbjct: 297 QLSEEEEEEEEEEEEEEEEEEEEEEE 322
Score = 45.4 bits (106), Expect = 3e-04
Identities = 26/69 (37%), Positives = 38/69 (55%), Gaps = 15/69 (21%)
Query: 415 EVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE---------------WGRKRPGRG 459
EV+ + + +++EEE+EEEEEEEEEEE+EEE+E +K+ +
Sbjct: 290 EVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKD 349
Query: 460 LPWTKLGRK 468
PW K RK
Sbjct: 350 SPWVKPSRK 358
Score = 45.1 bits (105), Expect = 3e-04
Identities = 22/34 (64%), Positives = 25/34 (73%)
Query: 417 KREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE 450
K EV +EEE+EEEEEEEEEEE+EEEEE
Sbjct: 288 KSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEE 321
Score = 38.9 bits (89), Expect = 0.025
Identities = 40/147 (27%), Positives = 59/147 (40%), Gaps = 39/147 (26%)
Query: 777 EEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCP 836
+E + S E + + E S E EEEEEE EEEEE+++EE S
Sbjct: 280 DERVDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQS-------- 331
Query: 837 YQSPPSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREK 896
RS SS W R++ +P ++ +RKRR++
Sbjct: 332 -------------DRSGSSGRRKAKKKW----RKD------------SPWVKPSRKRRKR 362
Query: 897 AIGEGRVVYIQNLSSDMSSRELKRRFE 923
R + +S+D SS E +R FE
Sbjct: 363 E--PPRAKEPRGVSNDTSSLETERGFE 387
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 47.8 bits (112), Expect = 5e-05
Identities = 28/62 (45%), Positives = 37/62 (59%), Gaps = 4/62 (6%)
Query: 427 QQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPW----TKLGRKLESSVCPVRRSRRL 482
+++EEE+EEEEEEEEEEE+EE+EE G + G K RK V P R+ R+
Sbjct: 303 EEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRKR 362
Query: 483 NP 484
P
Sbjct: 363 EP 364
Score = 45.8 bits (107), Expect = 2e-04
Identities = 20/26 (76%), Positives = 25/26 (96%)
Query: 425 RLQQQEEEDEEEEEEEEEEEKEEEEE 450
+L ++EEE+EEEEEEEEEEE+EEEEE
Sbjct: 297 QLSEEEEEEEEEEEEEEEEEEEEEEE 322
Score = 45.4 bits (106), Expect = 3e-04
Identities = 26/69 (37%), Positives = 38/69 (55%), Gaps = 15/69 (21%)
Query: 415 EVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE---------------WGRKRPGRG 459
EV+ + + +++EEE+EEEEEEEEEEE+EEE+E +K+ +
Sbjct: 290 EVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKD 349
Query: 460 LPWTKLGRK 468
PW K RK
Sbjct: 350 SPWVKPSRK 358
Score = 45.1 bits (105), Expect = 3e-04
Identities = 22/34 (64%), Positives = 25/34 (73%)
Query: 417 KREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE 450
K EV +EEE+EEEEEEEEEEE+EEEEE
Sbjct: 288 KSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEE 321
Score = 40.4 bits (93), Expect = 0.009
Identities = 41/159 (25%), Positives = 59/159 (37%), Gaps = 29/159 (18%)
Query: 777 EEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSD--- 833
+E + S E + + E S E EEEEEE EEEEE+++EE S
Sbjct: 280 DERVDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGR 339
Query: 834 ---------HCPYQSPPSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRT 884
P+ P K ++ R++ G + S P+ S S+ T
Sbjct: 340 RKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGT 399
Query: 885 PSIRHARKRREKAIGEGRVVYIQNLSSDMSSRELKRRFE 923
S HA +S+D SS E +R FE
Sbjct: 400 LSPNHA-----------------GVSNDTSSLETERGFE 421
Score = 32.0 bits (71), Expect = 3.1
Identities = 20/42 (47%), Positives = 25/42 (59%), Gaps = 5/42 (11%)
Query: 788 YDTVFEDS---SSSSGESSFLPEE--EEEEGEEEEEDDEEED 824
YD+ D S S E L E+ EEEE EEEEE++EEE+
Sbjct: 274 YDSYSVDERVDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEE 315
>gi|157266334 tubby like protein 1 [Homo sapiens]
Length = 542
Score = 47.8 bits (112), Expect = 5e-05
Identities = 54/204 (26%), Positives = 80/204 (39%), Gaps = 35/204 (17%)
Query: 373 SRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEE 432
S+PR P + R + A +P++ R P E K+ R L + +
Sbjct: 57 SKPRKPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDP---EAKKRDPRETFLVARAPD 113
Query: 433 DEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSRRLNPELGPWLTF 492
E+EEEEEEE+E++EEEE K+ LP K R+ S+ RR++
Sbjct: 114 AEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAK------------ 161
Query: 493 ADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGPQIPALESPCESG 552
P+G L S PK V R +P E + + + G
Sbjct: 162 ------AQGPRGDLGSPDPPPKPLRV-RNKEAPAGEGT-------------KMRKTKKKG 201
Query: 553 CGDMDEDPSCPQLPPRDSPRCLML 576
G+ D+DPS R SP + L
Sbjct: 202 SGEADKDPSGSPASARKSPAAMFL 225
Score = 31.6 bits (70), Expect = 4.0
Identities = 13/17 (76%), Positives = 16/17 (94%)
Query: 807 EEEEEEGEEEEEDDEEE 823
E+EEEE EE+EED+EEE
Sbjct: 115 EDEEEEEEEDEEDEEEE 131
Score = 30.8 bits (68), Expect = 6.8
Identities = 12/18 (66%), Positives = 17/18 (94%)
Query: 808 EEEEEGEEEEEDDEEEDS 825
E+EEE EEE+E+DEEE++
Sbjct: 115 EDEEEEEEEDEEDEEEEA 132
Score = 30.4 bits (67), Expect = 8.9
Identities = 28/101 (27%), Positives = 42/101 (41%), Gaps = 14/101 (13%)
Query: 806 PEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSP-PSKANRQLCSRSRSSSG-----SS 859
P+ E+EE EEEE++++EE+ P + P K++ L R + G S
Sbjct: 112 PDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGS 171
Query: 860 PCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGE 900
P P RN P + T RK ++K GE
Sbjct: 172 PDPPPKPLRVRN----KEAPAGEGT----KMRKTKKKGSGE 204
>gi|155030232 proline, glutamic acid and leucine rich protein 1
[Homo sapiens]
Length = 1130
Score = 47.4 bits (111), Expect = 7e-05
Identities = 67/234 (28%), Positives = 88/234 (37%), Gaps = 42/234 (17%)
Query: 231 GLQPPCLQS--PRL-PAKEDKEPGED-----CPSPQPAPASPQDSLALGRADPGAPVSQE 282
GL P L S PRL P E+ G + PS P P P D GR A V +
Sbjct: 710 GLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYD 769
Query: 283 -----DMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASW 337
D++ ++ +P+ LPP P P P + P P + A
Sbjct: 770 KEEASDVEISLESDSDDSVVIVPEG-LPPLPPPP-PSGATPPPIAPTGPPTASPPVPAK- 826
Query: 338 AEFSILRELLAQDVLCDVSKPYRL-ATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRI 396
+P L A P L P P PP + P V E
Sbjct: 827 ------------------EEPEELPAAP--GPLPPPPPPPPPVPGPVTLPPPQLVPE--- 863
Query: 397 AASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE 450
+P GP P+L + +++EEE+EEEEEEEEEE+ EEEEE
Sbjct: 864 -GTPGGGGP-PALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEE 915
Score = 46.2 bits (108), Expect = 2e-04
Identities = 60/226 (26%), Positives = 88/226 (38%), Gaps = 38/226 (16%)
Query: 255 PSPQPAPASPQDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPK 314
P P P P + LG + PG + +L+ + + P P P
Sbjct: 694 PVPSARPGPPTTANHLGLSVPGL------VSVPPRLLPGPENHRAGSNEDPILAPSGTPP 747
Query: 315 ACSNPSQQVRSR---PWSRHHSKASWAEFSILRELLAQDVLCDVSK---PYRLATPVYAS 368
P + R P H+ K ++ I E + D + V + P P A+
Sbjct: 748 PTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGAT 807
Query: 369 LTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRP----------SLRPLRL--EV 416
P + PP ASP P+ E + A+P P P +L P +L E
Sbjct: 808 PPPIAPTGPPT---ASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEG 864
Query: 417 KREVRRPARLQQ-----------QEEEDEEEEEEEEEEEKEEEEEW 451
P L++ +EEE+EEEEEEEEEEE+EEEE++
Sbjct: 865 TPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDF 910
Score = 38.1 bits (87), Expect = 0.043
Identities = 43/138 (31%), Positives = 51/138 (36%), Gaps = 11/138 (7%)
Query: 691 DHDYCQVLRPEGVLQRKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAGAPPK 750
D D V+ PEG+ L PSG G P A P +EE A P
Sbjct: 783 DSDDSVVIVPEGL---PPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPL 839
Query: 751 DSTLLRDHEIRASLTKHFGLLETALEEEDLASCKSP----EYDTVFEDSSSSSGESSFLP 806
+ +T L L E P E TV +SS E
Sbjct: 840 PPPPPPPPPVPGPVT----LPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEE 895
Query: 807 EEEEEEGEEEEEDDEEED 824
EEEEEE EEEEE+D EE+
Sbjct: 896 EEEEEEEEEEEEEDFEEE 913
Score = 35.8 bits (81), Expect = 0.21
Identities = 60/302 (19%), Positives = 111/302 (36%), Gaps = 47/302 (15%)
Query: 10 LDEELSSFFLNYLADTQGGGSGEEQLYADFPELDLSQLDASDFDSATCFGELQWCPENSE 69
L+E+L+ +N +D + EE+ + E + + + D F E + E E
Sbjct: 874 LEEDLTVININS-SDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEE---EEEE 929
Query: 70 TEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGDALSCTSASP 129
++ ++ EL + + E + E + L+++ + + G A +G A P
Sbjct: 930 EFEEEFEEEEGELEEEEEEEDE---EEEEELEEVEDLEFGTAGGEVEEG--------APP 978
Query: 130 APSSAPPSPAPEKPSAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWRQAGLRSKSQ 189
P+ P P PE P PE + LLL P + + R
Sbjct: 979 PPTLPPALPPPESPPKVQPEPEPEP---GLLLEVEEPGTEEE-------------RGADT 1022
Query: 190 RPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSPRLPAKEDKE 249
P + ++ + + +S + + L +++ PP L +E+ E
Sbjct: 1023 APTLAPEALPSQGEVEREGESPAAGPPPQEL------VEEEPSAPPTL------LEEETE 1070
Query: 250 PGEDCPSPQPAPASPQDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTP 309
G D P P + ++ A+ Q+D AM L ++ C P + PP
Sbjct: 1071 DGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAM--LADFID--CPPDDEKPPPPT 1126
Query: 310 EP 311
EP
Sbjct: 1127 EP 1128
Score = 35.4 bits (80), Expect = 0.28
Identities = 24/52 (46%), Positives = 29/52 (55%), Gaps = 6/52 (11%)
Query: 776 EEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGE---EEEEDDEEED 824
EEED + E + FE+ E F E EEEEGE EEEE+DEEE+
Sbjct: 906 EEEDFEEEEEDE-EEYFEEEEEE--EEEFEEEFEEEEGELEEEEEEEDEEEE 954
Score = 34.7 bits (78), Expect = 0.47
Identities = 24/66 (36%), Positives = 28/66 (42%)
Query: 776 EEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHC 835
EEED E + E E L EEEEEE EEEEE+ EE + T
Sbjct: 913 EEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEV 972
Query: 836 PYQSPP 841
+PP
Sbjct: 973 EEGAPP 978
Score = 33.9 bits (76), Expect = 0.81
Identities = 21/47 (44%), Positives = 23/47 (48%), Gaps = 2/47 (4%)
Query: 777 EEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEE 823
EEDL D E+ E EEEEEE EEEE+DEEE
Sbjct: 875 EEDLTVININSSDEEEEEEEEEEEEEE--EEEEEEEDFEEEEEDEEE 919
Score = 33.9 bits (76), Expect = 0.81
Identities = 20/48 (41%), Positives = 26/48 (54%), Gaps = 2/48 (4%)
Query: 776 EEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEE 823
EEE+ + E + FE+ E + EEEEEE E EEE +EEE
Sbjct: 894 EEEEEEEEEEEEEEEDFEEEEED--EEEYFEEEEEEEEEFEEEFEEEE 939
Score = 31.6 bits (70), Expect = 4.0
Identities = 19/49 (38%), Positives = 25/49 (51%)
Query: 776 EEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEED 824
EEE+ + E + ED + EEEEEE EE EE+ EEE+
Sbjct: 891 EEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEE 939
Score = 31.6 bits (70), Expect = 4.0
Identities = 38/132 (28%), Positives = 51/132 (38%), Gaps = 16/132 (12%)
Query: 714 PSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAG------APPKDSTLLRDHEIRASLTKH 767
P V E P+ G E + PG EE+R D A P + R+ E A+
Sbjct: 992 PPKVQPEPEPEPGL-LLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPP 1050
Query: 768 FGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEE---DDEEED 824
+ +EEE A E +T ED S P EEE E E E E + E++D
Sbjct: 1051 ----QELVEEEPSAPPTLLEEET--EDGSDKVQPPPETPAEEEMETETEAEALQEKEQDD 1104
Query: 825 SGVSPTCSDHCP 836
+ CP
Sbjct: 1105 TAAMLADFIDCP 1116
>gi|224994221 SH3-domain binding protein 2 isoform b [Homo sapiens]
Length = 618
Score = 47.0 bits (110), Expect = 9e-05
Identities = 55/211 (26%), Positives = 78/211 (36%), Gaps = 22/211 (10%)
Query: 234 PPCLQSPRLPAKED---------KEPGEDCPSPQPAPASPQDSLAL--GRADPGAPVSQE 282
PP + +PR PA D K PG P P P P LA + DP P E
Sbjct: 263 PPPVPTPRKPAFSDMPRAHSFTSKGPGPLLPPPPPKHGLPDVGLAAEDSKRDPLCPRRAE 322
Query: 283 DMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSI 342
+ R M P P P C S PW+ H S + +I
Sbjct: 323 PCPRVPATPRRMSD---PPLSTMPTAPGLRKPPCFRESASPSPEPWTPGHGACSTSSAAI 379
Query: 343 LRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKS 402
+ +++ CD K + L+ P S P P ++ + + + R AA P
Sbjct: 380 MATATSRN--CDKLKSFHLS----PRGPPTSEPPPVPANKPKFLKIAEEDPPREAAMPGL 433
Query: 403 TGPRPSLRP--LRLEVKREVRRPARLQQQEE 431
P + RP L+L V + RPA L + E+
Sbjct: 434 FVPPVAPRPPALKLPVPEAMARPAVLPRPEK 464
>gi|224994219 SH3-domain binding protein 2 isoform c [Homo sapiens]
Length = 589
Score = 47.0 bits (110), Expect = 9e-05
Identities = 55/211 (26%), Positives = 78/211 (36%), Gaps = 22/211 (10%)
Query: 234 PPCLQSPRLPAKED---------KEPGEDCPSPQPAPASPQDSLAL--GRADPGAPVSQE 282
PP + +PR PA D K PG P P P P LA + DP P E
Sbjct: 234 PPPVPTPRKPAFSDMPRAHSFTSKGPGPLLPPPPPKHGLPDVGLAAEDSKRDPLCPRRAE 293
Query: 283 DMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSI 342
+ R M P P P C S PW+ H S + +I
Sbjct: 294 PCPRVPATPRRMSD---PPLSTMPTAPGLRKPPCFRESASPSPEPWTPGHGACSTSSAAI 350
Query: 343 LRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKS 402
+ +++ CD K + L+ P S P P ++ + + + R AA P
Sbjct: 351 MATATSRN--CDKLKSFHLS----PRGPPTSEPPPVPANKPKFLKIAEEDPPREAAMPGL 404
Query: 403 TGPRPSLRP--LRLEVKREVRRPARLQQQEE 431
P + RP L+L V + RPA L + E+
Sbjct: 405 FVPPVAPRPPALKLPVPEAMARPAVLPRPEK 435
>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
Length = 1312
Score = 47.0 bits (110), Expect = 9e-05
Identities = 22/52 (42%), Positives = 33/52 (63%)
Query: 781 ASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCS 832
+SCK+PE + E+++ +G EEEEEE EEEEE++EEE + T +
Sbjct: 997 SSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTAT 1048
Score = 45.8 bits (107), Expect = 2e-04
Identities = 24/49 (48%), Positives = 32/49 (65%)
Query: 784 KSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCS 832
K ++ + SSS+G S EEEEEE EEEEE+DEEE+ G+S + S
Sbjct: 247 KYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSIS 295
Score = 44.7 bits (104), Expect = 5e-04
Identities = 59/204 (28%), Positives = 75/204 (36%), Gaps = 38/204 (18%)
Query: 264 PQDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQV 323
P D+ R D P EDM +V +R + + P PLP PS
Sbjct: 106 PPDTWVPSRLDL-RPGESEDMLELVAEVR-----------IGDRDPIPLPV----PSLLP 149
Query: 324 RSRPWSRHHSKASWAEFSILRELLAQDVLCDVSK--PYRLATPVYASLTPRSRPR----- 376
R R W + + + S R A+ + P P AS +P P
Sbjct: 150 RLRAWRTGKTVSPQSNSS--RPTCARHLTLGTGDGGPAPPPAPSSASSSPSPSPSSSSPS 207
Query: 377 --PPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRP--------ARL 426
PP A P P+ ++ P P P E K + P A
Sbjct: 208 PPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPAP---EQKYDPFEPTGSNPSSSAGT 264
Query: 427 QQQEEEDEEEEEEEEEEEKEEEEE 450
EEE+EEEEEEEEEEE EEEEE
Sbjct: 265 PSPEEEEEEEEEEEEEEEDEEEEE 288
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/92 (32%), Positives = 41/92 (44%), Gaps = 2/92 (2%)
Query: 363 TPVYASLTPRSRPRPPKDSQASPGRP--SSVEEVRIAASPKSTGPRPSLRPLRLEVKREV 420
+P +S +P P PP + +P P + S P P + E
Sbjct: 198 SPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSN 257
Query: 421 RRPARLQQQEEEDEEEEEEEEEEEKEEEEEWG 452
+ EE+EEEEEEEEEEE++EEEE G
Sbjct: 258 PSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEG 289
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/64 (42%), Positives = 33/64 (51%), Gaps = 7/64 (10%)
Query: 400 PKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEE-------EEEEEEEEEKEEEEEWG 452
PK+ P P+L P V + P EE EE EEEEEEEEE+EEEEE
Sbjct: 979 PKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEE 1038
Query: 453 RKRP 456
++P
Sbjct: 1039 EQQP 1042
Score = 41.2 bits (95), Expect = 0.005
Identities = 26/56 (46%), Positives = 32/56 (57%), Gaps = 13/56 (23%)
Query: 785 SPEYDTVFEDSSSSSGESSFLPEE-----------EEEEGEEEEEDDEEEDSGVSP 829
+P+ TV DSS + E SFLPEE EEEE EEEEE++EEE+ P
Sbjct: 989 TPDSQTV--DSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQP 1042
Score = 36.2 bits (82), Expect = 0.16
Identities = 88/416 (21%), Positives = 142/416 (34%), Gaps = 64/416 (15%)
Query: 65 PENSETEPNQYSPDDSELFQIDSENEAL---LAELTKTLDDIPEDDVGLAAFPALDGGDA 121
PE E E + ++ + + E E L ++ +++TL I +D+ FP GD
Sbjct: 267 PEEEEEEEEEEEEEEED----EEEEEGLSQSISRISETLAGIYDDNSLSQDFP----GDE 318
Query: 122 LSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWRQ 181
SP P + P P P P P P+VD + + ++ +EG +
Sbjct: 319 ------SPRPDAQPTQPTPA-PGTP-PQVDSTRADGAMRRRVFVVGTEAEACREGKVSVE 370
Query: 182 AGLRSKSQRP----------CVKADSTQDKKAPMMQ-SQSRSCTELHKHLTSAQCCLQDR 230
+ P + + Q ++ P + S R + +A +
Sbjct: 371 VVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPAASATPTAQ 430
Query: 231 GL-QPPCLQSPR------LPAKEDKEPGEDCPSPQPAPASPQDSLALGRADPGAPVSQED 283
L QPP ++P L A+ D E +PAPA P G D + +
Sbjct: 431 PLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQR 490
Query: 284 MQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSIL 343
+ RY +++ P P P P A + P + +SR + +A A S
Sbjct: 491 RE------RY-------RQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSS 537
Query: 344 RELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKST 403
A P A+P + S RSR R P +S R S R + +ST
Sbjct: 538 GTQPA---------PPAPASP-WDSKKHRSRDRKPGSHASSSARRRS----RSRSRSRST 583
Query: 404 GPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRG 459
R R R R + +++ E G+ R G G
Sbjct: 584 RRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGG 639
Score = 35.4 bits (80), Expect = 0.28
Identities = 39/168 (23%), Positives = 59/168 (35%), Gaps = 32/168 (19%)
Query: 114 PALDGGDALSCTSASPAPSSA-----PPSPAPEKPSAPAPEVDELSLLQKLLLATS---- 164
PA + + +S SP+PSS+ PP P P P+ PAP D A S
Sbjct: 184 PAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPA 243
Query: 165 --------YPTSSSDTQKEGTAWRQAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTEL 216
PT S+ + GT + + + + + ++++ + QS SR L
Sbjct: 244 PEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEE--EEEEDEEEEEGLSQSISRISETL 301
Query: 217 HKHLTSAQCCLQDRGLQPPCLQSPRLPAKEDKEPGEDCPSPQPAPASP 264
G+ S P E P P PAP +P
Sbjct: 302 -------------AGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTP 336
>gi|170014705 SH3-domain binding protein 2 isoform a [Homo sapiens]
Length = 561
Score = 47.0 bits (110), Expect = 9e-05
Identities = 55/211 (26%), Positives = 78/211 (36%), Gaps = 22/211 (10%)
Query: 234 PPCLQSPRLPAKED---------KEPGEDCPSPQPAPASPQDSLAL--GRADPGAPVSQE 282
PP + +PR PA D K PG P P P P LA + DP P E
Sbjct: 206 PPPVPTPRKPAFSDMPRAHSFTSKGPGPLLPPPPPKHGLPDVGLAAEDSKRDPLCPRRAE 265
Query: 283 DMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSI 342
+ R M P P P C S PW+ H S + +I
Sbjct: 266 PCPRVPATPRRMSD---PPLSTMPTAPGLRKPPCFRESASPSPEPWTPGHGACSTSSAAI 322
Query: 343 LRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKS 402
+ +++ CD K + L+ P S P P ++ + + + R AA P
Sbjct: 323 MATATSRN--CDKLKSFHLS----PRGPPTSEPPPVPANKPKFLKIAEEDPPREAAMPGL 376
Query: 403 TGPRPSLRP--LRLEVKREVRRPARLQQQEE 431
P + RP L+L V + RPA L + E+
Sbjct: 377 FVPPVAPRPPALKLPVPEAMARPAVLPRPEK 407
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,441,988
Number of Sequences: 37866
Number of extensions: 3165581
Number of successful extensions: 73902
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 774
Number of HSP's successfully gapped in prelim test: 758
Number of HSP's that attempted gapping in prelim test: 31419
Number of HSP's gapped (non-prelim): 25333
length of query: 1023
length of database: 18,247,518
effective HSP length: 112
effective length of query: 911
effective length of database: 14,006,526
effective search space: 12759945186
effective search space used: 12759945186
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.