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Search of human proteins with 31324547
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31324547 ankyrin repeat domain 25 [Homo sapiens]
(851 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209969812 ankyrin repeat domain 25 [Homo sapiens] 1685 0.0
gi|31324547 ankyrin repeat domain 25 [Homo sapiens] 1685 0.0
gi|157504499 ankyrin repeat domain 47 [Homo sapiens] 376 e-104
gi|23510377 KN motif and ankyrin repeat domains 1 isoform b [Hom... 330 4e-90
gi|64464726 KN motif and ankyrin repeat domains 1 isoform a [Hom... 330 4e-90
gi|156104862 ankyrin repeat domain 38 [Homo sapiens] 273 5e-73
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 82 2e-15
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 82 2e-15
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 75 3e-13
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 75 3e-13
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 75 3e-13
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 75 3e-13
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 73 1e-12
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 71 5e-12
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 69 2e-11
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 69 2e-11
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 69 2e-11
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 67 5e-11
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 67 5e-11
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 67 5e-11
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 67 5e-11
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 67 5e-11
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 67 5e-11
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 67 7e-11
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 66 1e-10
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 66 2e-10
gi|115495445 ankyrin repeat domain 30A [Homo sapiens] 65 2e-10
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 65 3e-10
gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain ... 65 3e-10
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 64 5e-10
>gi|209969812 ankyrin repeat domain 25 [Homo sapiens]
Length = 851
Score = 1685 bits (4363), Expect = 0.0
Identities = 851/851 (100%), Positives = 851/851 (100%)
Query: 1 MAQVLHVPAPFPGTPGPASPPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLR 60
MAQVLHVPAPFPGTPGPASPPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLR
Sbjct: 1 MAQVLHVPAPFPGTPGPASPPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLR 60
Query: 61 RVAVQRRPRLSSLPRGPGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGALETRGGF 120
RVAVQRRPRLSSLPRGPGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGALETRGGF
Sbjct: 61 RVAVQRRPRLSSLPRGPGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGALETRGGF 120
Query: 121 NPRVERTLLDARRRLEDQAATPTGLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVPP 180
NPRVERTLLDARRRLEDQAATPTGLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVPP
Sbjct: 121 NPRVERTLLDARRRLEDQAATPTGLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVPP 180
Query: 181 SAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPT 240
SAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPT
Sbjct: 181 SAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPT 240
Query: 241 AGRGRSELCLDLPDPPEDPVALETRSVGTWVRERDLGMPDGEAALAAKVAVLETQLKKAL 300
AGRGRSELCLDLPDPPEDPVALETRSVGTWVRERDLGMPDGEAALAAKVAVLETQLKKAL
Sbjct: 241 AGRGRSELCLDLPDPPEDPVALETRSVGTWVRERDLGMPDGEAALAAKVAVLETQLKKAL 300
Query: 301 QELQAAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLEPY 360
QELQAAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLEPY
Sbjct: 301 QELQAAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLEPY 360
Query: 361 GTGLRALAMPGRPESPPVFRSQEVVETMCPVPAAATSNVHMVKKISITERSCDGAAGLPE 420
GTGLRALAMPGRPESPPVFRSQEVVETMCPVPAAATSNVHMVKKISITERSCDGAAGLPE
Sbjct: 361 GTGLRALAMPGRPESPPVFRSQEVVETMCPVPAAATSNVHMVKKISITERSCDGAAGLPE 420
Query: 421 VPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVR 480
VPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVR
Sbjct: 421 VPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVR 480
Query: 481 SIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPS 540
SIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPS
Sbjct: 481 SIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPS 540
Query: 541 VAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLA 600
VAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLA
Sbjct: 541 VAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLA 600
Query: 601 LEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVV 660
LEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVV
Sbjct: 601 LEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVV 660
Query: 661 NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIE 720
NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIE
Sbjct: 661 NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIE 720
Query: 721 TVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCAC 780
TVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCAC
Sbjct: 721 TVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCAC 780
Query: 781 EHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSD 840
EHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSD
Sbjct: 781 EHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSD 840
Query: 841 DESPTSSSAEE 851
DESPTSSSAEE
Sbjct: 841 DESPTSSSAEE 851
>gi|31324547 ankyrin repeat domain 25 [Homo sapiens]
Length = 851
Score = 1685 bits (4363), Expect = 0.0
Identities = 851/851 (100%), Positives = 851/851 (100%)
Query: 1 MAQVLHVPAPFPGTPGPASPPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLR 60
MAQVLHVPAPFPGTPGPASPPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLR
Sbjct: 1 MAQVLHVPAPFPGTPGPASPPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLR 60
Query: 61 RVAVQRRPRLSSLPRGPGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGALETRGGF 120
RVAVQRRPRLSSLPRGPGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGALETRGGF
Sbjct: 61 RVAVQRRPRLSSLPRGPGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGALETRGGF 120
Query: 121 NPRVERTLLDARRRLEDQAATPTGLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVPP 180
NPRVERTLLDARRRLEDQAATPTGLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVPP
Sbjct: 121 NPRVERTLLDARRRLEDQAATPTGLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVPP 180
Query: 181 SAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPT 240
SAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPT
Sbjct: 181 SAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPT 240
Query: 241 AGRGRSELCLDLPDPPEDPVALETRSVGTWVRERDLGMPDGEAALAAKVAVLETQLKKAL 300
AGRGRSELCLDLPDPPEDPVALETRSVGTWVRERDLGMPDGEAALAAKVAVLETQLKKAL
Sbjct: 241 AGRGRSELCLDLPDPPEDPVALETRSVGTWVRERDLGMPDGEAALAAKVAVLETQLKKAL 300
Query: 301 QELQAAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLEPY 360
QELQAAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLEPY
Sbjct: 301 QELQAAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLEPY 360
Query: 361 GTGLRALAMPGRPESPPVFRSQEVVETMCPVPAAATSNVHMVKKISITERSCDGAAGLPE 420
GTGLRALAMPGRPESPPVFRSQEVVETMCPVPAAATSNVHMVKKISITERSCDGAAGLPE
Sbjct: 361 GTGLRALAMPGRPESPPVFRSQEVVETMCPVPAAATSNVHMVKKISITERSCDGAAGLPE 420
Query: 421 VPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVR 480
VPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVR
Sbjct: 421 VPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVR 480
Query: 481 SIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPS 540
SIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPS
Sbjct: 481 SIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPS 540
Query: 541 VAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLA 600
VAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLA
Sbjct: 541 VAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLA 600
Query: 601 LEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVV 660
LEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVV
Sbjct: 601 LEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVV 660
Query: 661 NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIE 720
NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIE
Sbjct: 661 NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIE 720
Query: 721 TVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCAC 780
TVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCAC
Sbjct: 721 TVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCAC 780
Query: 781 EHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSD 840
EHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSD
Sbjct: 781 EHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSD 840
Query: 841 DESPTSSSAEE 851
DESPTSSSAEE
Sbjct: 841 DESPTSSSAEE 851
>gi|157504499 ankyrin repeat domain 47 [Homo sapiens]
Length = 821
Score = 376 bits (966), Expect = e-104
Identities = 301/866 (34%), Positives = 421/866 (48%), Gaps = 124/866 (14%)
Query: 20 PPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVA---VQRRPRLS----S 72
P A A+ P PYSVETPYG+ LDLDFLKY++++E+G RR RRPR +
Sbjct: 22 PAAGGARSPSSPYSVETPYGFHLDLDFLKYIEELERGPAARRAPGPPTSRRPRAPRPGLA 81
Query: 73 LPRGPGSWWTSTESLCSNASG-DSRHSAYSYCGRGFYPQYGALETRGGFNPRVERTLLDA 131
R PG+W TS+ESL S+ G S + G P R NPRVE TL +
Sbjct: 82 GARSPGAW-TSSESLASDDGGAPGILSQGAPSGLLMQPLSPRAPVR---NPRVEHTLRET 137
Query: 132 RRRLEDQAATPTGLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVP------PSAGHL 185
RRLE + A G G+P +PR SG S+P P P L
Sbjct: 138 SRRLE-------------LAQTHERAPSPGRGVPR-SPRGSGRSSPAPNLAPASPGPAQL 183
Query: 186 AHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPTAGRGR 245
VREQMA ALR+LR+LE+Q + +P LQ ++ L+ EK +L AGR +
Sbjct: 184 QLVREQMAAALRRLRELEDQARTLPELQEQVRALRAEKARLL-------------AGRAQ 230
Query: 246 SELCLDLPDPPEDPVALETRSVGTWVRERDLGMPDGEAALAA-KVAVLETQLKKALQELQ 304
E PDGEA K+A L ++ +
Sbjct: 231 PE-------------------------------PDGEAETRPDKLAQLRRLTERLATSER 259
Query: 305 AAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLE--PYGT 362
+AR A P DSP + R + ++ + G P R + E P
Sbjct: 260 GGRAR-------ASPRADSPDGLAAGRSEGALQVLDGEVGSLDGTPQTREVAAEAVPETR 312
Query: 363 GLRALAMP-----GRPESPPVFRSQE-VVETMCPVPAAATSNVHMVKKISITERSCD--- 413
A A+P G +P + V E + +PAAA + +++ +R
Sbjct: 313 EAGAQAVPETREAGVEAAPETVEADAWVTEALLGLPAAAERELELLRASLEHQRGVSELL 372
Query: 414 -GAAGLPEVPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGT 472
G E E++ A L + T ++ E +A S E + G+
Sbjct: 373 RGRLRELEEAREAAEEAAAGARAQLREATTQTPWSCAEKAAQTESPAEAPSLTQESSPGS 432
Query: 473 -----GGPPAGV-RSIMKRKEEV--ADPTAHRRSLQFVGV-NGGYESSS-EDSSTAENIS 522
PAG+ +SIMK+++ A P++ +SLQFVGV NG YESSS ED+S ++ S
Sbjct: 433 MDGDRAVAPAGILKSIMKKRDGTPGAQPSSGPKSLQFVGVLNGEYESSSSEDASDSDGDS 492
Query: 523 DNDSTENEAPEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNT 582
+N E S + P + E + E Q + A+G
Sbjct: 493 ENGGAEPPGSSSGSGDDSGGGSDSGTPGPPSGGDIRDPEPEAEAEPQQV--AQG------ 544
Query: 583 EEEIRMELSPDLISACLALEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVR 642
R ELSP L AC+AL++ L P + A V QEW R++ + + E V
Sbjct: 545 ----RCELSPRLREACVALQRQLSRPRGVASDG--GAVRLVAQEWFRVSSQRRSQAEPVA 598
Query: 643 RHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGY 702
R L R + LL +VVN+AD NGNTALHYSVSH N + LLD+G C+V++QNRAGY
Sbjct: 599 RMLEGVRRLGPELLAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGY 658
Query: 703 SPIMLTALATLKTQD-DIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLAC 761
S +ML AL +++ ++ D+ V +LF +G++NAKASQ GQTALMLA+SHGR D+V LLAC
Sbjct: 659 SALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLAC 718
Query: 762 EADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEI 821
ADVN QD DG+TALMCA E+G + LLL P CD ++ D +G++AL +AL+A Q E+
Sbjct: 719 GADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEV 778
Query: 822 ASMLYSRMNIKCSFAPMSDDESPTSS 847
A++L++ ++ S P + ESP S
Sbjct: 779 AALLHAHLS---SGQPDTQSESPPGS 801
>gi|23510377 KN motif and ankyrin repeat domains 1 isoform b [Homo
sapiens]
Length = 1194
Score = 330 bits (845), Expect = 4e-90
Identities = 186/427 (43%), Positives = 258/427 (60%), Gaps = 22/427 (5%)
Query: 422 PAESSSSPPGSEVA-SLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVR 480
P S +S P EV S +P S PTQE T P Q + + ++
Sbjct: 759 PLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGT-LSPVNLTDDQIAAGLYACTNNESTLK 817
Query: 481 SIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDST----------ENE 530
SIMK+K+ D +++LQFVG+NGGYE++S D S+++ S ++S E E
Sbjct: 818 SIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEE 877
Query: 531 APEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMEL 590
E E +AE K++R E ++ + E R EL
Sbjct: 878 EEEEDEDTRGMAEGHHA--VNIEGLKSARVEDEMQ--------VQECEPEKVEIRERYEL 927
Query: 591 SPDLISACLALEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRA 650
S ++SAC L+ +++P ALT ++++ T+ EW R++ + A P +V ++ F A
Sbjct: 928 SEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEA 987
Query: 651 MSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTAL 710
+S +L YV+N+AD NGNTALHYSVSH+NF +V+ LLD+ VC VD QN+AGY+PIML AL
Sbjct: 988 ISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAAL 1047
Query: 711 ATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDD 770
A ++ + D+ V +LF G++NAKASQAGQTALMLAVSHGR+D+VK LLAC ADVN+QDD
Sbjct: 1048 AAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDD 1107
Query: 771 DGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMN 830
+GSTALMCA EHGH EI LLLA P C+ L D DGSTAL +AL+AG +IA +LY+ +N
Sbjct: 1108 EGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVN 1167
Query: 831 IKCSFAP 837
+ +P
Sbjct: 1168 FAKAQSP 1174
Score = 90.1 bits (222), Expect = 8e-18
Identities = 61/135 (45%), Positives = 81/135 (60%), Gaps = 12/135 (8%)
Query: 101 SYCGRGFYPQYGALETRGGFNPRVERTLLDARRRLEDQAATPTGLGSLTPSAAGSTASLV 160
S+ G G + G NP A+ +L++ GS P+A T S +
Sbjct: 28 SFGGMGTTSSLPSFVGSGNHNP--------AKHQLQNGYQGNGDYGSYAPAAP--TTSSM 77
Query: 161 GVGLPPPTPRSSGLSTPVPP-SAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVL 219
G + +P SSG+STPV S HL H+REQMA AL++L++LEEQV+ IPVLQVK+SVL
Sbjct: 78 GSSIRH-SPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELEEQVRTIPVLQVKISVL 136
Query: 220 QEEKRQLTVQLKSQK 234
QEEKRQL QLK+Q+
Sbjct: 137 QEEKRQLVSQLKNQR 151
>gi|64464726 KN motif and ankyrin repeat domains 1 isoform a [Homo
sapiens]
Length = 1352
Score = 330 bits (845), Expect = 4e-90
Identities = 186/427 (43%), Positives = 258/427 (60%), Gaps = 22/427 (5%)
Query: 422 PAESSSSPPGSEVA-SLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVR 480
P S +S P EV S +P S PTQE T P Q + + ++
Sbjct: 917 PLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGT-LSPVNLTDDQIAAGLYACTNNESTLK 975
Query: 481 SIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDST----------ENE 530
SIMK+K+ D +++LQFVG+NGGYE++S D S+++ S ++S E E
Sbjct: 976 SIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEE 1035
Query: 531 APEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMEL 590
E E +AE K++R E ++ + E R EL
Sbjct: 1036 EEEEDEDTRGMAEGHHA--VNIEGLKSARVEDEMQ--------VQECEPEKVEIRERYEL 1085
Query: 591 SPDLISACLALEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRA 650
S ++SAC L+ +++P ALT ++++ T+ EW R++ + A P +V ++ F A
Sbjct: 1086 SEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEA 1145
Query: 651 MSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTAL 710
+S +L YV+N+AD NGNTALHYSVSH+NF +V+ LLD+ VC VD QN+AGY+PIML AL
Sbjct: 1146 ISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAAL 1205
Query: 711 ATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDD 770
A ++ + D+ V +LF G++NAKASQAGQTALMLAVSHGR+D+VK LLAC ADVN+QDD
Sbjct: 1206 AAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDD 1265
Query: 771 DGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMN 830
+GSTALMCA EHGH EI LLLA P C+ L D DGSTAL +AL+AG +IA +LY+ +N
Sbjct: 1266 EGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVN 1325
Query: 831 IKCSFAP 837
+ +P
Sbjct: 1326 FAKAQSP 1332
Score = 147 bits (370), Expect = 5e-35
Identities = 113/287 (39%), Positives = 143/287 (49%), Gaps = 80/287 (27%)
Query: 26 KDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPRLSSLP-------RGPG 78
K+ PY VETPYGY+LDLDFLKYVDDI+KG+T++R+ +Q+R R S+P G
Sbjct: 25 KEQKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKRLNIQKR-RKPSVPCPEPRTTSGQQ 83
Query: 79 SWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGA------LETRGGF------------ 120
WTSTESL S+ S D++ R LET F
Sbjct: 84 GIWTSTESLSSSNSDDNKQCPNFLIARSQVTSTPISKPPPPLETSLPFLTIPENRQLPPP 143
Query: 121 -------NPRVERTLLDARRRLEDQAATPT-----------------GLGSLTPSAAGS- 155
N V +TL++ RRRLE + AT G S PS GS
Sbjct: 144 SPQLPKHNLHVTKTLMETRRRLEQERATMQMTPGEFRRPRLASFGGMGTTSSLPSFVGSG 203
Query: 156 ---------------------------TASLVGVGLPPPTPRSSGLSTPVPP-SAGHLAH 187
T S +G + +P SSG+STPV S HL H
Sbjct: 204 NHNPAKHQLQNGYQGNGDYGSYAPAAPTTSSMGSSIRH-SPLSSGISTPVTNVSPMHLQH 262
Query: 188 VREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQK 234
+REQMA AL++L++LEEQV+ IPVLQVK+SVLQEEKRQL QLK+Q+
Sbjct: 263 IREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQR 309
>gi|156104862 ankyrin repeat domain 38 [Homo sapiens]
Length = 995
Score = 273 bits (698), Expect = 5e-73
Identities = 171/466 (36%), Positives = 264/466 (56%), Gaps = 40/466 (8%)
Query: 370 PGRPESPPVFRSQEVVETMCPVPAAATSNVHMVKKISITERSCDGAAGLPEVPAESSSSP 429
PGRP S P A V ++++ + +C G PE+ S+
Sbjct: 548 PGRPPSSPT-------------DATIGQYVKKIQELLQEQWNCL-EHGYPELA--SAIKQ 591
Query: 430 PGSEVASLTQPEKST-----GRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVRSIMK 484
P S+++S+ S+ Q +EP ++S E + P ++SIMK
Sbjct: 592 PASKLSSIQSQLLSSLNLLLSAYSAQAHPPKEPPASSSSPPVEIS-----PSTSLKSIMK 646
Query: 485 RKEEV--ADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPS-- 540
+K+ A +++LQFVGVNGGYE++S + ++ E+ + D +++EA + +
Sbjct: 647 KKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCDGPDHKH 706
Query: 541 VAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLA 600
V +A AG + + Q S + +P ++ R + S + ++AC A
Sbjct: 707 VKDAHLTCEAGQGIPEGTCHAAQESGPGEEVPHSKAE---------RYKPSEEFLNACRA 757
Query: 601 LEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVV 660
L ++L T++ L+ + T+ QEW R++ R + P +V +L + S L +V
Sbjct: 758 LSQHLPETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLV 817
Query: 661 NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIE 720
N+AD NGNTALHYSVSH+NF +V+ LL++GVC VD QN+AGY+ +M+T LA+ +T +D+
Sbjct: 818 NLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMA 877
Query: 721 TVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCAC 780
V +L R GN+N +A+Q GQTALML VSH R D+V+ALL+C+ADVN+QD DGS+ALM AC
Sbjct: 878 VVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVAC 937
Query: 781 EHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDA-GQSEIASML 825
HG+ ++ LLLA P+CD SLTD+ G TAL +AL + EIA +L
Sbjct: 938 HHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLL 983
Score = 78.2 bits (191), Expect = 3e-14
Identities = 106/363 (29%), Positives = 159/363 (43%), Gaps = 77/363 (21%)
Query: 26 KDPDP--PYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRR---PRLSSLPRG---- 76
KDP PYSVETPYG+ LDLDFLKYVDDIEKG+T++R+ + RR + S+LPR
Sbjct: 17 KDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSLP 76
Query: 77 -PGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYG----ALETRGGFNPRVERTLLDA 131
G+ + L + + R ++ + P G A +R + + L +A
Sbjct: 77 DSGARPPAAPPLQNWSPVVPREASLGTQEQNQSPPLGNAPQASTSRSEVSYHRKALLAEA 136
Query: 132 RRRLEDQAATPTG----LGSLTPS---AAGSTASLV--------GVGLPPPTP------- 169
R+LE AA P GS P A+ A+L+ G+ L PP P
Sbjct: 137 TRQLE--AAEPEDAELTFGSGRPQLLRASSMPATLLHSRASEEPGLSLGPPAPPALPPLQ 194
Query: 170 -RSSGLSTPVPPSAGHLAHVREQMAGALRKLRQLEEQ--------VKL---IPV------ 211
S P+ G LA A ++ +L ++ VK+ +P+
Sbjct: 195 GEGSVCDGTFEPAEG-LAGFHSSSPRASTRIPELVQEGAEPPEGVVKVPNHLPLPGPPFS 253
Query: 212 LQVKLSVLQEEKRQLTVQLKSQKFL-GHPTAGR-------GRSELCLDLPD------PPE 257
Q L VL++++ + + F G PT +EL L+ + PP
Sbjct: 254 FQNVLVVLEDKEDEHNAREAEVLFTPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP 313
Query: 258 DPVALETRSVGTWVRERDLGM----PDGEAALAAKVAVLETQLKKALQELQAAQARQADP 313
PV ++ RS+G V E LG+ P ++L +V+ LE +L +EL AQ R A
Sbjct: 314 PPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVSALEGELSGRTEEL--AQVRTALQ 371
Query: 314 QPQ 316
Q +
Sbjct: 372 QQE 374
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 82.4 bits (202), Expect = 2e-15
Identities = 106/454 (23%), Positives = 179/454 (39%), Gaps = 57/454 (12%)
Query: 423 AESSSSPPGS----EVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEA------GGT 472
A S+SSP G ++ +P + + T R P+ +S +S+ + GG
Sbjct: 45 ARSASSPRGMVRVCDLLLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGG 104
Query: 473 GGPPAGVRSIMKRKEEVADPTAHRRS--LQFVGVNGGYESSSEDSST---AENISDNDST 527
GG G S +EE D S F+ E+ ++++ +D
Sbjct: 105 GGGGGGTSSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADL 164
Query: 528 ENEAPEPRERVPSVAEAPQLRPAGTAAAK-----------TSRQECQLSRESQHIPTAEG 576
PE + R+ ++ EA + TA K TS C L + +
Sbjct: 165 RTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRA 224
Query: 577 ASGSNTEEEIRMELSP-----------DLISACLALEKYLDNPNALTERELKVAYTTVLQ 625
S +N + L+ L+ ++ ++ + +L Y + Q
Sbjct: 225 ESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQ 284
Query: 626 EWLRL-------ACRSDAHPELVRR---HLVTFRAMSARLLDYVVNIADSNGNTALHYSV 675
L + + D P + H+ + + A D VN S GNTAL Y+
Sbjct: 285 VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKAD--VNAQSSTGNTALTYAC 342
Query: 676 SHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLG-NINAK 734
+ VV+ LL+SG ++ N G++P+M A +E L G IN
Sbjct: 343 AGGYVDVVKVLLESG-ASIEDHNENGHTPLMEAGSA-----GHVEVARLLLENGAGINTH 396
Query: 735 ASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAV 794
+++ ++AL LA G +++V+ LL AD + D+ TALM AC GH E+A LLL
Sbjct: 397 SNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD- 455
Query: 795 PSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
+++ + L +A G E+A++L R
Sbjct: 456 SGAQVNMPADSFESPLTLAACGGHVELAALLIER 489
Score = 58.5 bits (140), Expect = 2e-08
Identities = 78/286 (27%), Positives = 118/286 (41%), Gaps = 53/286 (18%)
Query: 575 EGASGSNTEEEIRMELSPDLISAC----LALEKYLDNPNALTERELKVAYTTVLQEWLRL 630
E +G NT E + L AC L + ++L A E + +T +++
Sbjct: 388 ENGAGINTHSNEFKESA--LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME----- 440
Query: 631 ACRSDAHPELVRRHLVTFRAMSARLLDY--VVNIADSNGNTALHYSVSHANFPVVQQLLD 688
AC D H E+ R LLD VN+ + + L + + + L++
Sbjct: 441 ACM-DGHVEVARL-----------LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 488
Query: 689 SGVCKVDKQNRAGYSPIMLTA-------LATL---------KTQDDIETVLQLFRLGNIN 732
G +++ N GY+P+M A +A L +T++ ET L L G
Sbjct: 489 RGA-SLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
Query: 733 AKAS---QAG-------QTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEH 782
A +AG T LM A G +++VK LLA A+V+ G TAL ACE+
Sbjct: 548 EVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACEN 607
Query: 783 GHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
GH ++A +LL D+ G T LM A AG L S+
Sbjct: 608 GHTDVADVLLQA-GADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
Score = 57.8 bits (138), Expect = 4e-08
Identities = 58/203 (28%), Positives = 91/203 (44%), Gaps = 17/203 (8%)
Query: 628 LRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLL 687
L LAC + H ELV+ L ++ R D G T L + + + VV+ LL
Sbjct: 1087 LTLAC-AGGHEELVQTLLERGASIEHR---------DKKGFTPLILAATAGHVGVVEILL 1136
Query: 688 DSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAV 747
D+G + R +P+ L + E V L G + + T L LA
Sbjct: 1137 DNGADIEAQSERTKDTPLSLACSGGRQ-----EVVELLLARGANKEHRNVSDYTPLSLAA 1191
Query: 748 SHGRVDVVKALLACEADVNVQDDD--GSTALMCACEHGHKEIAGLLLAVPSCDISLTDRD 805
S G V+++K LL A++N + G + LM A +GH LLL + S + + +
Sbjct: 1192 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETN 1251
Query: 806 GSTALMVALDAGQSEIASMLYSR 828
+TAL +A G++E+ S+L R
Sbjct: 1252 RNTALTLACFQGRTEVVSLLLDR 1274
Score = 56.6 bits (135), Expect = 9e-08
Identities = 44/138 (31%), Positives = 68/138 (49%), Gaps = 7/138 (5%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
V+ + G+TAL Y+ + + V LL +G ++ ++ G +P+M A A +
Sbjct: 590 VHATTATGDTALTYACENGHTDVADVLLQAGA-DLEHESEGGRTPLMKAARA-----GHV 643
Query: 720 ETVLQLFRLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMC 778
TV L G N+N + T L LA + G + VV+ LLA AD + DGST L+
Sbjct: 644 CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703
Query: 779 ACEHGHKEIAGLLLAVPS 796
A + GH + LL P+
Sbjct: 704 AAKGGHTSVVCYLLDYPN 721
Score = 53.1 bits (126), Expect = 1e-06
Identities = 50/165 (30%), Positives = 79/165 (47%), Gaps = 12/165 (7%)
Query: 669 TALHYSVSHANFPVVQQLLDSGVCKVDKQ--NRAGYSPIMLTALATLKTQDDIETVLQLF 726
T L + S +++ LL++G +++ + ++ G SP+ML A+ V L
Sbjct: 1185 TPLSLAASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAM-----NGHTAAVKLLL 1238
Query: 727 RLGN-INAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHK 785
+G+ INA+ TAL LA GR +VV LL +A+V + G T LM A G+
Sbjct: 1239 DMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1298
Query: 786 EIAGLLLAVPSCDISLTDRDGS--TALMVALDAGQSEIASMLYSR 828
E+ G +L D++ S TAL +A D G + +L R
Sbjct: 1299 EV-GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1342
Score = 51.2 bits (121), Expect = 4e-06
Identities = 45/168 (26%), Positives = 75/168 (44%), Gaps = 7/168 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
++N NTAL + VV LLD V+ + + G +P+M A ++ VL
Sbjct: 1249 ETNRNTALTLACFQGRTEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGYA---EVGRVL 1304
Query: 724 QLFRLGNINAKASQAGQ-TALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEH 782
L + ++NA + + TAL +A G + L+ A ++V++ G+T L A
Sbjct: 1305 -LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANG 1363
Query: 783 GHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMN 830
GH ++ LL+ D+ D T LM A G ++ L +N
Sbjct: 1364 GHLDVVQLLVQA-GADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN 1410
Score = 33.1 bits (74), Expect = 1.1
Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 2/63 (3%)
Query: 764 DVNVQDDDG-STALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIA 822
D++ Q + TAL AC GH+E+ LL I D+ G T L++A AG +
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLE-RGASIEHRDKKGFTPLILAATAGHVGVV 1132
Query: 823 SML 825
+L
Sbjct: 1133 EIL 1135
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 82.4 bits (202), Expect = 2e-15
Identities = 106/454 (23%), Positives = 179/454 (39%), Gaps = 57/454 (12%)
Query: 423 AESSSSPPGS----EVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEA------GGT 472
A S+SSP G ++ +P + + T R P+ +S +S+ + GG
Sbjct: 45 ARSASSPRGMVRVCDLLLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGG 104
Query: 473 GGPPAGVRSIMKRKEEVADPTAHRRS--LQFVGVNGGYESSSEDSST---AENISDNDST 527
GG G S +EE D S F+ E+ ++++ +D
Sbjct: 105 GGGGGGTSSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADL 164
Query: 528 ENEAPEPRERVPSVAEAPQLRPAGTAAAK-----------TSRQECQLSRESQHIPTAEG 576
PE + R+ ++ EA + TA K TS C L + +
Sbjct: 165 RTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRA 224
Query: 577 ASGSNTEEEIRMELSP-----------DLISACLALEKYLDNPNALTERELKVAYTTVLQ 625
S +N + L+ L+ ++ ++ + +L Y + Q
Sbjct: 225 ESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQ 284
Query: 626 EWLRL-------ACRSDAHPELVRR---HLVTFRAMSARLLDYVVNIADSNGNTALHYSV 675
L + + D P + H+ + + A D VN S GNTAL Y+
Sbjct: 285 VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKAD--VNAQSSTGNTALTYAC 342
Query: 676 SHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLG-NINAK 734
+ VV+ LL+SG ++ N G++P+M A +E L G IN
Sbjct: 343 AGGYVDVVKVLLESG-ASIEDHNENGHTPLMEAGSA-----GHVEVARLLLENGAGINTH 396
Query: 735 ASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAV 794
+++ ++AL LA G +++V+ LL AD + D+ TALM AC GH E+A LLL
Sbjct: 397 SNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD- 455
Query: 795 PSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
+++ + L +A G E+A++L R
Sbjct: 456 SGAQVNMPADSFESPLTLAACGGHVELAALLIER 489
Score = 60.5 bits (145), Expect = 7e-09
Identities = 82/306 (26%), Positives = 127/306 (41%), Gaps = 30/306 (9%)
Query: 529 NEAPE-PRERVPSVA--EAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEE 585
N AP P + +P V + P PA A R + R S T + ++ +
Sbjct: 742 NRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQP 801
Query: 586 IRMELSPDLI-SACLALEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRH 644
SP + SA L + +D +A TE A T LAC + H ELV+
Sbjct: 802 QTPTPSPIISPSAMLPIYPAIDI-DAQTESNHDTALT--------LAC-AGGHEELVQTL 851
Query: 645 LVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSP 704
L ++ R D G T L + + + VV+ LLD+G + R +P
Sbjct: 852 LERGASIEHR---------DKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTP 902
Query: 705 IMLTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEAD 764
+ L + E V L G + + T L LA S G V+++K LL A+
Sbjct: 903 LSLACSGGRQ-----EVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 957
Query: 765 VNVQDDD--GSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIA 822
+N + G + LM A +GH LLL + S + + + +TAL +A G++E+
Sbjct: 958 INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1017
Query: 823 SMLYSR 828
S+L R
Sbjct: 1018 SLLLDR 1023
Score = 58.5 bits (140), Expect = 2e-08
Identities = 78/286 (27%), Positives = 118/286 (41%), Gaps = 53/286 (18%)
Query: 575 EGASGSNTEEEIRMELSPDLISAC----LALEKYLDNPNALTERELKVAYTTVLQEWLRL 630
E +G NT E + L AC L + ++L A E + +T +++
Sbjct: 388 ENGAGINTHSNEFKESA--LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME----- 440
Query: 631 ACRSDAHPELVRRHLVTFRAMSARLLDY--VVNIADSNGNTALHYSVSHANFPVVQQLLD 688
AC D H E+ R LLD VN+ + + L + + + L++
Sbjct: 441 ACM-DGHVEVARL-----------LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 488
Query: 689 SGVCKVDKQNRAGYSPIMLTA-------LATL---------KTQDDIETVLQLFRLGNIN 732
G +++ N GY+P+M A +A L +T++ ET L L G
Sbjct: 489 RGA-SLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
Query: 733 AKAS---QAG-------QTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEH 782
A +AG T LM A G +++VK LLA A+V+ G TAL ACE+
Sbjct: 548 EVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACEN 607
Query: 783 GHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
GH ++A +LL D+ G T LM A AG L S+
Sbjct: 608 GHTDVADVLLQA-GADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
Score = 56.6 bits (135), Expect = 9e-08
Identities = 44/138 (31%), Positives = 68/138 (49%), Gaps = 7/138 (5%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
V+ + G+TAL Y+ + + V LL +G ++ ++ G +P+M A A +
Sbjct: 590 VHATTATGDTALTYACENGHTDVADVLLQAGA-DLEHESEGGRTPLMKAARA-----GHV 643
Query: 720 ETVLQLFRLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMC 778
TV L G N+N + T L LA + G + VV+ LLA AD + DGST L+
Sbjct: 644 CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703
Query: 779 ACEHGHKEIAGLLLAVPS 796
A + GH + LL P+
Sbjct: 704 AAKGGHTSVVCYLLDYPN 721
Score = 53.1 bits (126), Expect = 1e-06
Identities = 50/165 (30%), Positives = 79/165 (47%), Gaps = 12/165 (7%)
Query: 669 TALHYSVSHANFPVVQQLLDSGVCKVDKQ--NRAGYSPIMLTALATLKTQDDIETVLQLF 726
T L + S +++ LL++G +++ + ++ G SP+ML A+ V L
Sbjct: 934 TPLSLAASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAM-----NGHTAAVKLLL 987
Query: 727 RLGN-INAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHK 785
+G+ INA+ TAL LA GR +VV LL +A+V + G T LM A G+
Sbjct: 988 DMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1047
Query: 786 EIAGLLLAVPSCDISLTDRDGS--TALMVALDAGQSEIASMLYSR 828
E+ G +L D++ S TAL +A D G + +L R
Sbjct: 1048 EV-GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1091
Score = 51.2 bits (121), Expect = 4e-06
Identities = 45/168 (26%), Positives = 75/168 (44%), Gaps = 7/168 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
++N NTAL + VV LLD V+ + + G +P+M A ++ VL
Sbjct: 998 ETNRNTALTLACFQGRTEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGYA---EVGRVL 1053
Query: 724 QLFRLGNINAKASQAGQ-TALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEH 782
L + ++NA + + TAL +A G + L+ A ++V++ G+T L A
Sbjct: 1054 -LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANG 1112
Query: 783 GHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMN 830
GH ++ LL+ D+ D T LM A G ++ L +N
Sbjct: 1113 GHLDVVQLLVQA-GADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN 1159
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 75.1 bits (183), Expect = 3e-13
Identities = 90/341 (26%), Positives = 139/341 (40%), Gaps = 45/341 (13%)
Query: 515 SSTAENISDNDSTENEAPEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTA 574
SSTAE PE + R+ ++ EA TS C L + +
Sbjct: 127 SSTAEGAD----LRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRM 182
Query: 575 EGASGSNTEEEIRMELSPDLISACL-ALEKYLDNPNALTERELKVAYTTVLQEWLRLACR 633
+ + N + L+ + A+ K LD ++ E +T + L LAC
Sbjct: 183 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNE------HTEEGESLLCLAC- 235
Query: 634 SDAHPELVRRHLVT----------------FRAMSARLLDYV---------VNIADSNGN 668
S + EL + L A S LD V VN + GN
Sbjct: 236 SAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN 295
Query: 669 TALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRL 728
TAL Y+ + +V+ LL+ G ++ N G++P+M A A +E L
Sbjct: 296 TALTYACAGGFVDIVKVLLNEGA-NIEDHNENGHTPLMEAASA-----GHVEVARVLLDH 349
Query: 729 G-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEI 787
G IN +++ ++AL LA G +D+V+ LL AD + D+ TALM AC GH E+
Sbjct: 350 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 409
Query: 788 AGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
A LLL +++ + L +A G E+A++L R
Sbjct: 410 ARLLLD-SGAQVNMPADSFESPLTLAACGGHVELAALLIER 449
Score = 67.4 bits (163), Expect = 5e-11
Identities = 78/271 (28%), Positives = 119/271 (43%), Gaps = 36/271 (13%)
Query: 576 GASGSNTEEEIRMELSPDLISACLALEKYLDNPNALTERELKVAYTTV------------ 623
GASGS+ +E +E + + ++ LDNP T E+ ++ T
Sbjct: 91 GASGSDEDEVSEVE-------SFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQ 143
Query: 624 --LQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTA-------LHYS 674
L+ L A +D PE++RR + + + N + A L +
Sbjct: 144 ARLEALLEAAAFAD--PEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEA 201
Query: 675 VSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGNINAK 734
S + V++LLD G V++ G S L LA ++ VL L N+ +
Sbjct: 202 CSDGDVNAVRKLLDEGR-SVNEHTEEGES---LLCLACSAGYYELAQVL-LAMHANVEDR 256
Query: 735 ASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAV 794
++ T LM A S G +D+VK LL +ADVN Q G+TAL AC G +I +LL
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN- 315
Query: 795 PSCDISLTDRDGSTALMVALDAGQSEIASML 825
+I + +G T LM A AG E+A +L
Sbjct: 316 EGANIEDHNENGHTPLMEAASAGHVEVARVL 346
Score = 57.8 bits (138), Expect = 4e-08
Identities = 47/166 (28%), Positives = 79/166 (47%), Gaps = 9/166 (5%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
VN+ + + L + + + L++ G +++ N GY+P+M A + +
Sbjct: 420 VNMPADSFESPLTLAACGGHVELAALLIERGA-NLEEVNDEGYTPLMEAA----REGHEE 474
Query: 720 ETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCA 779
L L + NINA+ + +TAL LA G +V L+ AD+ + ST LM A
Sbjct: 475 MVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEA 531
Query: 780 CEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
+ GH E+ LLA ++ T G TAL A + G +++A +L
Sbjct: 532 SQEGHLELVKYLLA-SGANVHATTATGDTALTYACENGHTDVADVL 576
Score = 51.2 bits (121), Expect = 4e-06
Identities = 39/125 (31%), Positives = 62/125 (49%), Gaps = 15/125 (12%)
Query: 683 VQQLLDSGVCKVDKQNRAGYSPIMLTALA-----TLKTQDDIETVLQLFRLGNINAKAS- 736
++++ D G + + R G+ ++ LA +T++ ET L L G + A
Sbjct: 453 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADF 512
Query: 737 --QAG-------QTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEI 787
+AG T LM A G +++VK LLA A+V+ G TAL ACE+GH ++
Sbjct: 513 LIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 572
Query: 788 AGLLL 792
A +LL
Sbjct: 573 ADVLL 577
Score = 32.3 bits (72), Expect = 1.9
Identities = 22/64 (34%), Positives = 31/64 (48%), Gaps = 2/64 (3%)
Query: 708 TALATLKTQDDIETVLQLFRLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVN 766
T L + +E V L G N++A + G TAL A +G DV LL AD++
Sbjct: 526 TPLMEASQEGHLELVKYLLASGANVHATTA-TGDTALTYACENGHTDVADVLLQAGADLD 584
Query: 767 VQDD 770
Q+D
Sbjct: 585 KQED 588
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 74.7 bits (182), Expect = 3e-13
Identities = 57/175 (32%), Positives = 88/175 (50%), Gaps = 8/175 (4%)
Query: 655 LLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLK 714
L D VN + GNTAL Y+ + +V+ LL+ G ++ N G++P+M A A
Sbjct: 293 LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-NIEDHNENGHTPLMEAASA--- 348
Query: 715 TQDDIETVLQLFRLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGS 773
+E L G IN +++ ++AL LA G +D+V+ LL AD + D+
Sbjct: 349 --GHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
Query: 774 TALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
TALM AC GH E+A LLL +++ + L +A G E+A++L R
Sbjct: 407 TALMEACMDGHVEVARLLLD-SGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
Score = 63.2 bits (152), Expect = 1e-09
Identities = 54/156 (34%), Positives = 78/156 (50%), Gaps = 6/156 (3%)
Query: 670 ALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLG 729
+L + S + V++LLD G V++ G S L LA ++ VL L
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGR-SVNEHTEEGES---LLCLACSAGYYELAQVL-LAMHA 262
Query: 730 NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAG 789
N+ + ++ T LM A S G +D+VK LL +ADVN Q G+TAL AC G +I
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 790 LLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
+LL +I + +G T LM A AG E+A +L
Sbjct: 323 VLLN-EGANIEDHNENGHTPLMEAASAGHVEVARVL 357
Score = 57.8 bits (138), Expect = 4e-08
Identities = 47/166 (28%), Positives = 79/166 (47%), Gaps = 9/166 (5%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
VN+ + + L + + + L++ G +++ N GY+P+M A + +
Sbjct: 431 VNMPADSFESPLTLAACGGHVELAALLIERGA-NLEEVNDEGYTPLMEAA----REGHEE 485
Query: 720 ETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCA 779
L L + NINA+ + +TAL LA G +V L+ AD+ + ST LM A
Sbjct: 486 MVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEA 542
Query: 780 CEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
+ GH E+ LLA ++ T G TAL A + G +++A +L
Sbjct: 543 SQEGHLELVKYLLA-SGANVHATTATGDTALTYACENGHTDVADVL 587
Score = 51.2 bits (121), Expect = 4e-06
Identities = 39/125 (31%), Positives = 62/125 (49%), Gaps = 15/125 (12%)
Query: 683 VQQLLDSGVCKVDKQNRAGYSPIMLTALA-----TLKTQDDIETVLQLFRLGNINAKAS- 736
++++ D G + + R G+ ++ LA +T++ ET L L G + A
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADF 523
Query: 737 --QAG-------QTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEI 787
+AG T LM A G +++VK LLA A+V+ G TAL ACE+GH ++
Sbjct: 524 LIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
Query: 788 AGLLL 792
A +LL
Sbjct: 584 ADVLL 588
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/91 (31%), Positives = 44/91 (48%)
Query: 735 ASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAV 794
A Q +L A S G V+ V+ LL VN ++G + L AC G+ E+A +LLA+
Sbjct: 201 AGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM 260
Query: 795 PSCDISLTDRDGSTALMVALDAGQSEIASML 825
+ ++ T LM A G +I +L
Sbjct: 261 HANVEDRGNKGDITPLMAASSGGYLDIVKLL 291
Score = 32.3 bits (72), Expect = 1.9
Identities = 22/64 (34%), Positives = 31/64 (48%), Gaps = 2/64 (3%)
Query: 708 TALATLKTQDDIETVLQLFRLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVN 766
T L + +E V L G N++A + G TAL A +G DV LL AD++
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTA-TGDTALTYACENGHTDVADVLLQAGADLD 595
Query: 767 VQDD 770
Q+D
Sbjct: 596 KQED 599
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 74.7 bits (182), Expect = 3e-13
Identities = 57/175 (32%), Positives = 88/175 (50%), Gaps = 8/175 (4%)
Query: 655 LLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLK 714
L D VN + GNTAL Y+ + +V+ LL+ G ++ N G++P+M A A
Sbjct: 293 LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-NIEDHNENGHTPLMEAASA--- 348
Query: 715 TQDDIETVLQLFRLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGS 773
+E L G IN +++ ++AL LA G +D+V+ LL AD + D+
Sbjct: 349 --GHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
Query: 774 TALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
TALM AC GH E+A LLL +++ + L +A G E+A++L R
Sbjct: 407 TALMEACMDGHVEVARLLLD-SGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
Score = 63.2 bits (152), Expect = 1e-09
Identities = 54/156 (34%), Positives = 78/156 (50%), Gaps = 6/156 (3%)
Query: 670 ALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLG 729
+L + S + V++LLD G V++ G S L LA ++ VL L
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGR-SVNEHTEEGES---LLCLACSAGYYELAQVL-LAMHA 262
Query: 730 NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAG 789
N+ + ++ T LM A S G +D+VK LL +ADVN Q G+TAL AC G +I
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 790 LLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
+LL +I + +G T LM A AG E+A +L
Sbjct: 323 VLLN-EGANIEDHNENGHTPLMEAASAGHVEVARVL 357
Score = 58.5 bits (140), Expect = 2e-08
Identities = 49/161 (30%), Positives = 74/161 (45%), Gaps = 16/161 (9%)
Query: 683 VQQLLDSGVCKVDKQNRAGYSPIMLTALA-----TLKTQDDIETVLQLFRLGNINAKAS- 736
++++ D G + + R G+ ++ LA +T++ ET L L G + A
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADF 523
Query: 737 --QAG-------QTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEI 787
+AG T LM A G +++VK LLA A+V+ G TAL ACE+GH ++
Sbjct: 524 LIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
Query: 788 AGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
A +LL D+ G T LM A AG L S+
Sbjct: 584 ADVLLQA-GADLEHESEGGRTPLMKAARAGHLCTVQFLISK 623
Score = 58.2 bits (139), Expect = 3e-08
Identities = 46/149 (30%), Positives = 73/149 (48%), Gaps = 7/149 (4%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
V+ + G+TAL Y+ + + V LL +G ++ ++ G +P+M A A +
Sbjct: 561 VHATTATGDTALTYACENGHTDVADVLLQAGA-DLEHESEGGRTPLMKAARA-----GHL 614
Query: 720 ETVLQLFRLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMC 778
TV L G N+N + T + LA + G + VV+ LLA AD + DGST L+
Sbjct: 615 CTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 674
Query: 779 ACEHGHKEIAGLLLAVPSCDISLTDRDGS 807
A + GH + LL P+ +S+ D S
Sbjct: 675 AAKGGHTNVVSYLLDYPNNVLSVPTTDVS 703
Score = 54.3 bits (129), Expect = 5e-07
Identities = 50/165 (30%), Positives = 80/165 (48%), Gaps = 12/165 (7%)
Query: 669 TALHYSVSHANFPVVQQLLDSGVCKVDKQ--NRAGYSPIMLTALATLKTQDDIETVLQLF 726
T L + S +++ LL++G +++ + ++ G SP+ML A+ + V L
Sbjct: 1157 TPLSLAASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAM-----NGHVPAVKLLL 1210
Query: 727 RLGN-INAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHK 785
+G+ INA+ TAL LA GR +VV LL +A+V + G T LM A G+
Sbjct: 1211 DMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1270
Query: 786 EIAGLLLAVPSCDISLTDRDGS--TALMVALDAGQSEIASMLYSR 828
E+ G +L D++ S TAL +A D G + +L R
Sbjct: 1271 EV-GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR 1314
Score = 49.3 bits (116), Expect = 2e-05
Identities = 45/168 (26%), Positives = 75/168 (44%), Gaps = 7/168 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
++N NTAL + VV LLD V+ + + G +P+M A ++ VL
Sbjct: 1221 ETNRNTALTLACFQGRAEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGYA---EVGRVL 1276
Query: 724 QLFRLGNINAKASQAGQ-TALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEH 782
L + ++NA + + TAL +A G + L+ A ++V++ G+T L A
Sbjct: 1277 -LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335
Query: 783 GHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMN 830
GH ++ LL+ D+ D T LM A G ++ L +N
Sbjct: 1336 GHFDVVQLLVQA-GADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 1382
Score = 47.0 bits (110), Expect = 7e-05
Identities = 53/201 (26%), Positives = 90/201 (44%), Gaps = 42/201 (20%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETV- 722
+SN +TAL + + + +V L+ K++ +++ G++P++L A T + V
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDA-KIEHRDKKGFTPLILAA-----TAGHVGVVE 1105
Query: 723 LQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADV---NVQDDD-------- 771
+ L + G+I A++ + T L LA S GR +VV LLA A+ NV D
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 772 ------------------------GSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGS 807
G + LM A +GH LLL + S + + + +
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225
Query: 808 TALMVALDAGQSEIASMLYSR 828
TAL +A G++E+ S+L R
Sbjct: 1226 TALTLACFQGRAEVVSLLLDR 1246
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/91 (31%), Positives = 44/91 (48%)
Query: 735 ASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAV 794
A Q +L A S G V+ V+ LL VN ++G + L AC G+ E+A +LLA+
Sbjct: 201 AGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM 260
Query: 795 PSCDISLTDRDGSTALMVALDAGQSEIASML 825
+ ++ T LM A G +I +L
Sbjct: 261 HANVEDRGNKGDITPLMAASSGGYLDIVKLL 291
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 74.7 bits (182), Expect = 3e-13
Identities = 57/175 (32%), Positives = 88/175 (50%), Gaps = 8/175 (4%)
Query: 655 LLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLK 714
L D VN + GNTAL Y+ + +V+ LL+ G ++ N G++P+M A A
Sbjct: 293 LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-NIEDHNENGHTPLMEAASA--- 348
Query: 715 TQDDIETVLQLFRLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGS 773
+E L G IN +++ ++AL LA G +D+V+ LL AD + D+
Sbjct: 349 --GHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
Query: 774 TALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
TALM AC GH E+A LLL +++ + L +A G E+A++L R
Sbjct: 407 TALMEACMDGHVEVARLLLD-SGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
Score = 63.2 bits (152), Expect = 1e-09
Identities = 54/156 (34%), Positives = 78/156 (50%), Gaps = 6/156 (3%)
Query: 670 ALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLG 729
+L + S + V++LLD G V++ G S L LA ++ VL L
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGR-SVNEHTEEGES---LLCLACSAGYYELAQVL-LAMHA 262
Query: 730 NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAG 789
N+ + ++ T LM A S G +D+VK LL +ADVN Q G+TAL AC G +I
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 790 LLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
+LL +I + +G T LM A AG E+A +L
Sbjct: 323 VLLN-EGANIEDHNENGHTPLMEAASAGHVEVARVL 357
Score = 58.5 bits (140), Expect = 2e-08
Identities = 49/161 (30%), Positives = 74/161 (45%), Gaps = 16/161 (9%)
Query: 683 VQQLLDSGVCKVDKQNRAGYSPIMLTALA-----TLKTQDDIETVLQLFRLGNINAKAS- 736
++++ D G + + R G+ ++ LA +T++ ET L L G + A
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADF 523
Query: 737 --QAG-------QTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEI 787
+AG T LM A G +++VK LLA A+V+ G TAL ACE+GH ++
Sbjct: 524 LIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
Query: 788 AGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
A +LL D+ G T LM A AG L S+
Sbjct: 584 ADVLLQA-GADLEHESEGGRTPLMKAARAGHLCTVQFLISK 623
Score = 58.2 bits (139), Expect = 3e-08
Identities = 46/149 (30%), Positives = 73/149 (48%), Gaps = 7/149 (4%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
V+ + G+TAL Y+ + + V LL +G ++ ++ G +P+M A A +
Sbjct: 561 VHATTATGDTALTYACENGHTDVADVLLQAGA-DLEHESEGGRTPLMKAARA-----GHL 614
Query: 720 ETVLQLFRLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMC 778
TV L G N+N + T + LA + G + VV+ LLA AD + DGST L+
Sbjct: 615 CTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 674
Query: 779 ACEHGHKEIAGLLLAVPSCDISLTDRDGS 807
A + GH + LL P+ +S+ D S
Sbjct: 675 AAKGGHTNVVSYLLDYPNNVLSVPTTDVS 703
Score = 54.3 bits (129), Expect = 5e-07
Identities = 50/165 (30%), Positives = 80/165 (48%), Gaps = 12/165 (7%)
Query: 669 TALHYSVSHANFPVVQQLLDSGVCKVDKQ--NRAGYSPIMLTALATLKTQDDIETVLQLF 726
T L + S +++ LL++G +++ + ++ G SP+ML A+ + V L
Sbjct: 1157 TPLSLAASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAM-----NGHVPAVKLLL 1210
Query: 727 RLGN-INAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHK 785
+G+ INA+ TAL LA GR +VV LL +A+V + G T LM A G+
Sbjct: 1211 DMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1270
Query: 786 EIAGLLLAVPSCDISLTDRDGS--TALMVALDAGQSEIASMLYSR 828
E+ G +L D++ S TAL +A D G + +L R
Sbjct: 1271 EV-GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR 1314
Score = 49.3 bits (116), Expect = 2e-05
Identities = 45/168 (26%), Positives = 75/168 (44%), Gaps = 7/168 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
++N NTAL + VV LLD V+ + + G +P+M A ++ VL
Sbjct: 1221 ETNRNTALTLACFQGRAEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGYA---EVGRVL 1276
Query: 724 QLFRLGNINAKASQAGQ-TALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEH 782
L + ++NA + + TAL +A G + L+ A ++V++ G+T L A
Sbjct: 1277 -LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335
Query: 783 GHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMN 830
GH ++ LL+ D+ D T LM A G ++ L +N
Sbjct: 1336 GHFDVVQLLVQA-GADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 1382
Score = 47.0 bits (110), Expect = 7e-05
Identities = 53/201 (26%), Positives = 90/201 (44%), Gaps = 42/201 (20%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETV- 722
+SN +TAL + + + +V L+ K++ +++ G++P++L A T + V
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDA-KIEHRDKKGFTPLILAA-----TAGHVGVVE 1105
Query: 723 LQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADV---NVQDDD-------- 771
+ L + G+I A++ + T L LA S GR +VV LLA A+ NV D
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 772 ------------------------GSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGS 807
G + LM A +GH LLL + S + + + +
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225
Query: 808 TALMVALDAGQSEIASMLYSR 828
TAL +A G++E+ S+L R
Sbjct: 1226 TALTLACFQGRAEVVSLLLDR 1246
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/91 (31%), Positives = 44/91 (48%)
Query: 735 ASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAV 794
A Q +L A S G V+ V+ LL VN ++G + L AC G+ E+A +LLA+
Sbjct: 201 AGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM 260
Query: 795 PSCDISLTDRDGSTALMVALDAGQSEIASML 825
+ ++ T LM A G +I +L
Sbjct: 261 HANVEDRGNKGDITPLMAASSGGYLDIVKLL 291
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 73.2 bits (178), Expect = 1e-12
Identities = 57/206 (27%), Positives = 91/206 (44%), Gaps = 40/206 (19%)
Query: 656 LDYVV------NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTA 709
LD++V N+ D GNTALH + + V+Q+L+D G+ +++QN G + + A
Sbjct: 175 LDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGL-DLEEQNAEGLTALHSAA 233
Query: 710 ------------------------------LATLKTQDDIETVLQLFRLGNINAKASQAG 739
A L +D+ VL G G
Sbjct: 234 GGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVL--IHAGGCANVVDHQG 291
Query: 740 QTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDI 799
+ L LAV H +V+ L+ ++DVN D+ T L A EH ++IA +LL + D+
Sbjct: 292 ASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLL-IAGVDL 350
Query: 800 SLTDRDGSTALMVALDAGQSEIASML 825
+L D+ G TAL VA+ + + M+
Sbjct: 351 NLRDKQGKTALAVAVRSNHVSLVDMI 376
Score = 47.0 bits (110), Expect = 7e-05
Identities = 44/166 (26%), Positives = 78/166 (46%), Gaps = 19/166 (11%)
Query: 667 GNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTA-------LATLKTQDDI 719
G AL S + ++Q L++SG K+ +++ G + + A LA + +D+
Sbjct: 91 GMNALLLSAWFGHLRILQILVNSGA-KIHCESKDGLTLLHCAAQKGHVPVLAFI--MEDL 147
Query: 720 ETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCA 779
E V L +++ + G+TA A HG++D + L+ D NV+D +G+TAL A
Sbjct: 148 EDVA----LDHVD----KLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLA 199
Query: 780 CEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
GH + L+ + D+ + +G TAL A + +L
Sbjct: 200 AGRGHMAVLQRLVDI-GLDLEEQNAEGLTALHSAAGGSHPDCVQLL 244
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 70.9 bits (172), Expect = 5e-12
Identities = 52/169 (30%), Positives = 79/169 (46%), Gaps = 2/169 (1%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
VN AD+ G TAL + + +V+ LLD G +V+ ++ G + + + AL ++
Sbjct: 670 VNKADNEGRTALIAAAYMGHREIVEHLLDHGA-EVNHEDVDGRTALSVAALCVPASKGHA 728
Query: 720 ETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCA 779
V L G + G T L++A G VDVV LL ADV+ D++G T L+ A
Sbjct: 729 SVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAA 788
Query: 780 CEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
GH + LL + + D +G T L +A G E+ L R
Sbjct: 789 ASMGHASVVNTLLFWGAA-VDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836
Score = 65.9 bits (159), Expect = 2e-10
Identities = 69/211 (32%), Positives = 95/211 (45%), Gaps = 18/211 (8%)
Query: 625 QEWLRLACRSDAH--PELVRRHLVTFRAMSAR-----LLDY--VVNIADSNGNTALHYSV 675
QE L+L ++ AH E R + +A+ LLD VN DSNG T L +
Sbjct: 494 QEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAA 553
Query: 676 SHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLG-NINAK 734
+ VV L+ G ++ ++ G++P+ L A Q + V L G NIN
Sbjct: 554 YSGSLDVVNLLVSRG-ADLEIEDAHGHTPLTLAA-----RQGHTKVVNCLIGCGANIN-H 606
Query: 735 ASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAV 794
Q G TAL A G +VV ALL V+ D D TAL A GH++I L L
Sbjct: 607 TDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIV-LNLLQ 665
Query: 795 PSCDISLTDRDGSTALMVALDAGQSEIASML 825
+++ D +G TAL+ A G EI L
Sbjct: 666 HGAEVNKADNEGRTALIAAAYMGHREIVEHL 696
Score = 63.5 bits (153), Expect = 8e-10
Identities = 50/162 (30%), Positives = 73/162 (45%), Gaps = 12/162 (7%)
Query: 634 SDAHPELVRRHLVTFRAMSARLLDYVVNI--ADSNGNTALHYSVSHANFPVVQQLL--DS 689
+D P L L M+ L+ N+ +D+ G TALH S + +VQ L+ +
Sbjct: 944 ADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA 1003
Query: 690 GVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSH 749
V D + R+ AL + Q ++ V L G + G TAL +A
Sbjct: 1004 DVNAADNEKRS--------ALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQE 1055
Query: 750 GRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLL 791
G +DVV+ LL AD N D G TA+ A ++GH +I LL
Sbjct: 1056 GHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097
Score = 60.1 bits (144), Expect = 9e-09
Identities = 54/174 (31%), Positives = 80/174 (45%), Gaps = 12/174 (6%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
+ I D++G+T L + + VV L+ G ++ ++ G+ TAL +
Sbjct: 571 LEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA-NINHTDQDGW-----TALRSAAWGGHT 624
Query: 720 ETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCA 779
E V L G A +TAL A G D+V LL A+VN D++G TAL+ A
Sbjct: 625 EVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAA 684
Query: 780 CEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVA-----LDAGQSEIASMLYSR 828
GH+EI LL +++ D DG TAL VA G + + S+L R
Sbjct: 685 AYMGHREIVEHLLD-HGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR 737
Score = 59.7 bits (143), Expect = 1e-08
Identities = 54/180 (30%), Positives = 78/180 (43%), Gaps = 12/180 (6%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSG--VCKVDKQNRAGYSPIMLTALATLKTQD 717
V+ D+NG T L + S + VV LL G V +D + R T L+ Q
Sbjct: 774 VDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR--------TVLSIASAQG 825
Query: 718 DIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALM 777
++E V L G AG T L +A G + +AL+ A N D+DG +
Sbjct: 826 NVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFI 885
Query: 778 CACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR-MNIKCSFA 836
A + GH + +LL S +I DG AL VA G +I +L+S ++ C A
Sbjct: 886 LASQEGHYDCVQILLENKS-NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDA 944
Score = 57.8 bits (138), Expect = 4e-08
Identities = 44/161 (27%), Positives = 79/161 (49%), Gaps = 9/161 (5%)
Query: 666 NGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQL 725
+G AL + + +V+ L G V+ ++ G + + AL ++ T+ +
Sbjct: 912 DGRNALRVAALEGHRDIVELLFSHGA-DVNCKDADGRPTLYILAL------ENQLTMAEY 964
Query: 726 FRLGNINAKASQA-GQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGH 784
F N +AS A G+TAL ++ G +++V+ L+A ADVN D++ +AL A GH
Sbjct: 965 FLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGH 1024
Query: 785 KEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
++ LL+ + T G+TAL +A G ++ +L
Sbjct: 1025 VKVVQLLIE-HGAVVDHTCNQGATALCIAAQEGHIDVVQVL 1064
Score = 52.4 bits (124), Expect = 2e-06
Identities = 46/166 (27%), Positives = 69/166 (41%), Gaps = 7/166 (4%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
V+ D +G T L + + VV LL+ G VD + G +P++ A +
Sbjct: 741 VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGA-DVDHTDNNGRTPLLAAA-----SMGHA 794
Query: 720 ETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCA 779
V L G G+T L +A + G V+VV+ LL D N +DD G T L A
Sbjct: 795 SVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMA 854
Query: 780 CEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
GH+ I L+ + D DG ++A G + +L
Sbjct: 855 AFEGHRLICEALIE-QGARTNEIDNDGRIPFILASQEGHYDCVQIL 899
Score = 52.0 bits (123), Expect = 2e-06
Identities = 53/183 (28%), Positives = 85/183 (46%), Gaps = 12/183 (6%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
VN D++G L+ + + L++G V+ + G TAL Q +
Sbjct: 939 VNCKDADGRPTLYILALENQLTMAEYFLENGA-NVEASDAEGR-----TALHVSCWQGHM 992
Query: 720 ETVLQLFRL-GNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMC 778
E V L ++NA A ++AL A G V VV+ L+ A V+ + G+TAL
Sbjct: 993 EMVQVLIAYHADVNA-ADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCI 1051
Query: 779 ACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML--YSRMNIK-CSF 835
A + GH ++ +LL D + D+ G TA+ VA G S+I +L Y ++ CS
Sbjct: 1052 AAQEGHIDVVQVLLE-HGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSP 1110
Query: 836 APM 838
+P+
Sbjct: 1111 SPV 1113
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 68.9 bits (167), Expect = 2e-11
Identities = 53/188 (28%), Positives = 87/188 (46%), Gaps = 16/188 (8%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
+N + NG ALH + + +VQ+LL G VD + G + + + +LA
Sbjct: 36 INTCNQNGLNALHLAAKEGHVGLVQELLGRG-SSVDSATKKGNTALHIASLA-----GQA 89
Query: 720 ETVLQLFRLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMC 778
E V L + G NINA+ SQ G T L +A +DVVK LL A+ + +DG T L
Sbjct: 90 EVVKVLVKEGANINAQ-SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAV 148
Query: 779 ACEHGHKEIAGLLL--------AVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMN 830
A + GH + +LL +P+ I+ D +A ++ + +++ S +
Sbjct: 149 ALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRT 208
Query: 831 IKCSFAPM 838
+ F P+
Sbjct: 209 TESGFTPL 216
Score = 58.9 bits (141), Expect = 2e-08
Identities = 50/177 (28%), Positives = 80/177 (45%), Gaps = 9/177 (5%)
Query: 651 MSARLLDY--VVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLT 708
+++ LL+Y NI G T LH + + +V LLD G + ++G LT
Sbjct: 623 IASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-NIHMSTKSG-----LT 676
Query: 709 ALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQ 768
+L +D + L + G ++ G T L++A +G V +V LL A+VN +
Sbjct: 677 SLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK 736
Query: 769 DDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
+G T L A + GH I +LL + T +G+TAL +A G + L
Sbjct: 737 TKNGYTPLHQAAQQGHTHIINVLLQ-HGAKPNATTANGNTALAIAKRLGYISVVDTL 792
Score = 56.6 bits (135), Expect = 9e-08
Identities = 44/161 (27%), Positives = 75/161 (46%), Gaps = 7/161 (4%)
Query: 665 SNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQ 724
S+ N + + N V + L G+ ++ N+ G + + L A + + V +
Sbjct: 8 SDSNASFLRAARAGNLDKVVEYLKGGI-DINTCNQNGLNALHLAA-----KEGHVGLVQE 61
Query: 725 LFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGH 784
L G+ A++ G TAL +A G+ +VVK L+ A++N Q +G T L A + H
Sbjct: 62 LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 121
Query: 785 KEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
++ LL + S DG T L VAL G ++ ++L
Sbjct: 122 IDVVKYLLE-NGANQSTATEDGFTPLAVALQQGHNQAVAIL 161
Score = 55.5 bits (132), Expect = 2e-07
Identities = 66/239 (27%), Positives = 102/239 (42%), Gaps = 21/239 (8%)
Query: 601 LEKYLDNPNALTERELKVAYTTVLQEWLR---LACRSDAHPELVRRHLVTFRAMSARLLD 657
L KY + A+TE L + L L ++ A P++ T M+AR
Sbjct: 396 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 455
Query: 658 Y-VVNIADSNG----------NTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIM 706
VV NG T LH + +VQ LL + D GY+P+
Sbjct: 456 VEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH-MAHPDAATTNGYTPLH 514
Query: 707 LTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVN 766
++A + Q D+ +VL G ++ A++ G T L +A +G +DV K LL A +
Sbjct: 515 ISAR---EGQVDVASVL--LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 569
Query: 767 VQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
+G T L A + ++++A LLL T ++G T L +A Q +IAS L
Sbjct: 570 SAGKNGLTPLHVAAHYDNQKVA-LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 627
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/240 (24%), Positives = 100/240 (41%), Gaps = 19/240 (7%)
Query: 598 CLALEKYLDNPNALTERE-LKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSAR-- 654
CL L + A E+ L +A E ++L + AHP+ + T +SAR
Sbjct: 461 CLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520
Query: 655 -------LLDYVV--NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPI 705
LL+ ++A G T LH + + + V + LL D + G +P+
Sbjct: 521 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA-ADSAGKNGLTPL 579
Query: 706 MLTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADV 765
+ A D+ + L L G ++ G T L +A ++ + LL A+
Sbjct: 580 HVAA-----HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 634
Query: 766 NVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
N+ G T L A + GH ++ LLL +I ++ + G T+L +A + +A +L
Sbjct: 635 NIVTKQGVTPLHLASQEGHTDMVTLLLD-KGANIHMSTKSGLTSLHLAAQEDKVNVADIL 693
Score = 48.5 bits (114), Expect = 3e-05
Identities = 52/172 (30%), Positives = 76/172 (44%), Gaps = 11/172 (6%)
Query: 659 VVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDD 718
+VN +G T LH + + N V LL+ G VD R G +P+ + + K +
Sbjct: 204 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA-VDFTARNGITPLHVAS----KRGNT 258
Query: 719 IETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMC 778
L L R G I+AK ++ G T L A G VV+ LL A + + +G + L
Sbjct: 259 NMVKLLLDRGGQIDAK-TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHM 317
Query: 779 ACEHGHKEIAGLLL--AVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
A + H E LL P D++L D TAL VA G + +L +
Sbjct: 318 AAQGDHVECVKHLLQHKAPVDDVTL---DYLTALHVAAHCGHYRVTKLLLDK 366
Score = 44.3 bits (103), Expect = 5e-04
Identities = 47/164 (28%), Positives = 68/164 (41%), Gaps = 15/164 (9%)
Query: 666 NGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIE----T 721
NG + LH + + V+ LL Q++A + L L L T
Sbjct: 310 NGLSPLHMAAQGDHVECVKHLL---------QHKAPVDDVTLDYLTALHVAAHCGHYRVT 360
Query: 722 VLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACE 781
L L + N NA+A G T L +A R+ V++ L+ A + + G T + A
Sbjct: 361 KLLLDKRANPNARALN-GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAF 419
Query: 782 HGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
GH I LLL +T+ G TAL +A AGQ E+ L
Sbjct: 420 MGHLNIV-LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462
Score = 39.7 bits (91), Expect = 0.012
Identities = 43/160 (26%), Positives = 70/160 (43%), Gaps = 7/160 (4%)
Query: 666 NGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQL 725
+G T LH + + VV+ LL+ G + + + G SP+ + A D +E V L
Sbjct: 277 DGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKNGLSPLHMAAQG-----DHVECVKHL 330
Query: 726 FRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHK 785
+ + TAL +A G V K LL A+ N + +G T L AC+
Sbjct: 331 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 390
Query: 786 EIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
++ LL+ + ++T+ G T + VA G I +L
Sbjct: 391 KVMELLVKYGASIQAITE-SGLTPIHVAAFMGHLNIVLLL 429
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 68.9 bits (167), Expect = 2e-11
Identities = 53/188 (28%), Positives = 87/188 (46%), Gaps = 16/188 (8%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
+N + NG ALH + + +VQ+LL G VD + G + + + +LA
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRG-SSVDSATKKGNTALHIASLA-----GQA 110
Query: 720 ETVLQLFRLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMC 778
E V L + G NINA+ SQ G T L +A +DVVK LL A+ + +DG T L
Sbjct: 111 EVVKVLVKEGANINAQ-SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAV 169
Query: 779 ACEHGHKEIAGLLL--------AVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMN 830
A + GH + +LL +P+ I+ D +A ++ + +++ S +
Sbjct: 170 ALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRT 229
Query: 831 IKCSFAPM 838
+ F P+
Sbjct: 230 TESGFTPL 237
Score = 58.9 bits (141), Expect = 2e-08
Identities = 50/177 (28%), Positives = 80/177 (45%), Gaps = 9/177 (5%)
Query: 651 MSARLLDY--VVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLT 708
+++ LL+Y NI G T LH + + +V LLD G + ++G LT
Sbjct: 644 IASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-NIHMSTKSG-----LT 697
Query: 709 ALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQ 768
+L +D + L + G ++ G T L++A +G V +V LL A+VN +
Sbjct: 698 SLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK 757
Query: 769 DDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
+G T L A + GH I +LL + T +G+TAL +A G + L
Sbjct: 758 TKNGYTPLHQAAQQGHTHIINVLLQ-HGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 56.6 bits (135), Expect = 9e-08
Identities = 44/161 (27%), Positives = 75/161 (46%), Gaps = 7/161 (4%)
Query: 665 SNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQ 724
S+ N + + N V + L G+ ++ N+ G + + L A + + V +
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGI-DINTCNQNGLNALHLAA-----KEGHVGLVQE 82
Query: 725 LFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGH 784
L G+ A++ G TAL +A G+ +VVK L+ A++N Q +G T L A + H
Sbjct: 83 LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 142
Query: 785 KEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
++ LL + S DG T L VAL G ++ ++L
Sbjct: 143 IDVVKYLLE-NGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Score = 55.5 bits (132), Expect = 2e-07
Identities = 66/239 (27%), Positives = 102/239 (42%), Gaps = 21/239 (8%)
Query: 601 LEKYLDNPNALTERELKVAYTTVLQEWLR---LACRSDAHPELVRRHLVTFRAMSARLLD 657
L KY + A+TE L + L L ++ A P++ T M+AR
Sbjct: 417 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 476
Query: 658 Y-VVNIADSNG----------NTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIM 706
VV NG T LH + +VQ LL + D GY+P+
Sbjct: 477 VEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH-MAHPDAATTNGYTPLH 535
Query: 707 LTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVN 766
++A + Q D+ +VL G ++ A++ G T L +A +G +DV K LL A +
Sbjct: 536 ISAR---EGQVDVASVL--LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
Query: 767 VQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
+G T L A + ++++A LLL T ++G T L +A Q +IAS L
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVA-LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/240 (24%), Positives = 100/240 (41%), Gaps = 19/240 (7%)
Query: 598 CLALEKYLDNPNALTERE-LKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSAR-- 654
CL L + A E+ L +A E ++L + AHP+ + T +SAR
Sbjct: 482 CLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
Query: 655 -------LLDYVV--NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPI 705
LL+ ++A G T LH + + + V + LL D + G +P+
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA-ADSAGKNGLTPL 600
Query: 706 MLTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADV 765
+ A D+ + L L G ++ G T L +A ++ + LL A+
Sbjct: 601 HVAA-----HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655
Query: 766 NVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
N+ G T L A + GH ++ LLL +I ++ + G T+L +A + +A +L
Sbjct: 656 NIVTKQGVTPLHLASQEGHTDMVTLLLD-KGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 48.5 bits (114), Expect = 3e-05
Identities = 52/172 (30%), Positives = 76/172 (44%), Gaps = 11/172 (6%)
Query: 659 VVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDD 718
+VN +G T LH + + N V LL+ G VD R G +P+ + + K +
Sbjct: 225 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA-VDFTARNGITPLHVAS----KRGNT 279
Query: 719 IETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMC 778
L L R G I+AK ++ G T L A G VV+ LL A + + +G + L
Sbjct: 280 NMVKLLLDRGGQIDAK-TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHM 338
Query: 779 ACEHGHKEIAGLLL--AVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
A + H E LL P D++L D TAL VA G + +L +
Sbjct: 339 AAQGDHVECVKHLLQHKAPVDDVTL---DYLTALHVAAHCGHYRVTKLLLDK 387
Score = 44.3 bits (103), Expect = 5e-04
Identities = 47/164 (28%), Positives = 68/164 (41%), Gaps = 15/164 (9%)
Query: 666 NGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIE----T 721
NG + LH + + V+ LL Q++A + L L L T
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLL---------QHKAPVDDVTLDYLTALHVAAHCGHYRVT 381
Query: 722 VLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACE 781
L L + N NA+A G T L +A R+ V++ L+ A + + G T + A
Sbjct: 382 KLLLDKRANPNARALN-GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAF 440
Query: 782 HGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
GH I LLL +T+ G TAL +A AGQ E+ L
Sbjct: 441 MGHLNIV-LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Score = 39.7 bits (91), Expect = 0.012
Identities = 43/160 (26%), Positives = 70/160 (43%), Gaps = 7/160 (4%)
Query: 666 NGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQL 725
+G T LH + + VV+ LL+ G + + + G SP+ + A D +E V L
Sbjct: 298 DGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKNGLSPLHMAAQG-----DHVECVKHL 351
Query: 726 FRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHK 785
+ + TAL +A G V K LL A+ N + +G T L AC+
Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 411
Query: 786 EIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
++ LL+ + ++T+ G T + VA G I +L
Sbjct: 412 KVMELLVKYGASIQAITE-SGLTPIHVAAFMGHLNIVLLL 450
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 68.9 bits (167), Expect = 2e-11
Identities = 53/188 (28%), Positives = 87/188 (46%), Gaps = 16/188 (8%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
+N + NG ALH + + +VQ+LL G VD + G + + + +LA
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRG-SSVDSATKKGNTALHIASLA-----GQA 110
Query: 720 ETVLQLFRLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMC 778
E V L + G NINA+ SQ G T L +A +DVVK LL A+ + +DG T L
Sbjct: 111 EVVKVLVKEGANINAQ-SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAV 169
Query: 779 ACEHGHKEIAGLLL--------AVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMN 830
A + GH + +LL +P+ I+ D +A ++ + +++ S +
Sbjct: 170 ALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRT 229
Query: 831 IKCSFAPM 838
+ F P+
Sbjct: 230 TESGFTPL 237
Score = 58.9 bits (141), Expect = 2e-08
Identities = 50/177 (28%), Positives = 80/177 (45%), Gaps = 9/177 (5%)
Query: 651 MSARLLDY--VVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLT 708
+++ LL+Y NI G T LH + + +V LLD G + ++G LT
Sbjct: 644 IASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-NIHMSTKSG-----LT 697
Query: 709 ALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQ 768
+L +D + L + G ++ G T L++A +G V +V LL A+VN +
Sbjct: 698 SLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK 757
Query: 769 DDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
+G T L A + GH I +LL + T +G+TAL +A G + L
Sbjct: 758 TKNGYTPLHQAAQQGHTHIINVLLQ-HGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 56.6 bits (135), Expect = 9e-08
Identities = 44/161 (27%), Positives = 75/161 (46%), Gaps = 7/161 (4%)
Query: 665 SNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQ 724
S+ N + + N V + L G+ ++ N+ G + + L A + + V +
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGI-DINTCNQNGLNALHLAA-----KEGHVGLVQE 82
Query: 725 LFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGH 784
L G+ A++ G TAL +A G+ +VVK L+ A++N Q +G T L A + H
Sbjct: 83 LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 142
Query: 785 KEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
++ LL + S DG T L VAL G ++ ++L
Sbjct: 143 IDVVKYLLE-NGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Score = 55.5 bits (132), Expect = 2e-07
Identities = 66/239 (27%), Positives = 102/239 (42%), Gaps = 21/239 (8%)
Query: 601 LEKYLDNPNALTERELKVAYTTVLQEWLR---LACRSDAHPELVRRHLVTFRAMSARLLD 657
L KY + A+TE L + L L ++ A P++ T M+AR
Sbjct: 417 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 476
Query: 658 Y-VVNIADSNG----------NTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIM 706
VV NG T LH + +VQ LL + D GY+P+
Sbjct: 477 VEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH-MAHPDAATTNGYTPLH 535
Query: 707 LTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVN 766
++A + Q D+ +VL G ++ A++ G T L +A +G +DV K LL A +
Sbjct: 536 ISAR---EGQVDVASVL--LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
Query: 767 VQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
+G T L A + ++++A LLL T ++G T L +A Q +IAS L
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVA-LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/240 (24%), Positives = 100/240 (41%), Gaps = 19/240 (7%)
Query: 598 CLALEKYLDNPNALTERE-LKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSAR-- 654
CL L + A E+ L +A E ++L + AHP+ + T +SAR
Sbjct: 482 CLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
Query: 655 -------LLDYVV--NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPI 705
LL+ ++A G T LH + + + V + LL D + G +P+
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA-ADSAGKNGLTPL 600
Query: 706 MLTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADV 765
+ A D+ + L L G ++ G T L +A ++ + LL A+
Sbjct: 601 HVAA-----HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655
Query: 766 NVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
N+ G T L A + GH ++ LLL +I ++ + G T+L +A + +A +L
Sbjct: 656 NIVTKQGVTPLHLASQEGHTDMVTLLLD-KGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 48.5 bits (114), Expect = 3e-05
Identities = 52/172 (30%), Positives = 76/172 (44%), Gaps = 11/172 (6%)
Query: 659 VVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDD 718
+VN +G T LH + + N V LL+ G VD R G +P+ + + K +
Sbjct: 225 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA-VDFTARNGITPLHVAS----KRGNT 279
Query: 719 IETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMC 778
L L R G I+AK ++ G T L A G VV+ LL A + + +G + L
Sbjct: 280 NMVKLLLDRGGQIDAK-TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHM 338
Query: 779 ACEHGHKEIAGLLL--AVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
A + H E LL P D++L D TAL VA G + +L +
Sbjct: 339 AAQGDHVECVKHLLQHKAPVDDVTL---DYLTALHVAAHCGHYRVTKLLLDK 387
Score = 44.3 bits (103), Expect = 5e-04
Identities = 47/164 (28%), Positives = 68/164 (41%), Gaps = 15/164 (9%)
Query: 666 NGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIE----T 721
NG + LH + + V+ LL Q++A + L L L T
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLL---------QHKAPVDDVTLDYLTALHVAAHCGHYRVT 381
Query: 722 VLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACE 781
L L + N NA+A G T L +A R+ V++ L+ A + + G T + A
Sbjct: 382 KLLLDKRANPNARALN-GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAF 440
Query: 782 HGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
GH I LLL +T+ G TAL +A AGQ E+ L
Sbjct: 441 MGHLNIV-LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Score = 39.7 bits (91), Expect = 0.012
Identities = 43/160 (26%), Positives = 70/160 (43%), Gaps = 7/160 (4%)
Query: 666 NGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQL 725
+G T LH + + VV+ LL+ G + + + G SP+ + A D +E V L
Sbjct: 298 DGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKNGLSPLHMAAQG-----DHVECVKHL 351
Query: 726 FRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHK 785
+ + TAL +A G V K LL A+ N + +G T L AC+
Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 411
Query: 786 EIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
++ LL+ + ++T+ G T + VA G I +L
Sbjct: 412 KVMELLVKYGASIQAITE-SGLTPIHVAAFMGHLNIVLLL 450
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 67.4 bits (163), Expect = 5e-11
Identities = 46/165 (27%), Positives = 80/165 (48%), Gaps = 7/165 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
DS G TA H + + + ++ ++ GV V Q+ G+S + L A E +
Sbjct: 53 DSEGKTAFHLAAAKGHVECLRVMITHGV-DVTAQDTTGHSALHLAA-----KNSHHECIR 106
Query: 724 QLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHG 783
+L + +G+TAL A + G + V+ L ++ +N++D DG+ L+ A ++G
Sbjct: 107 KLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNG 166
Query: 784 HKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
H EI LL D++ ++ G TALM+A + G S L +
Sbjct: 167 HSEICHFLLD-HGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 210
Score = 47.4 bits (111), Expect = 6e-05
Identities = 44/138 (31%), Positives = 71/138 (51%), Gaps = 6/138 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
DS+G TALHY+ + VQ L + ++ ++ G P++L A +I L
Sbjct: 119 DSSGKTALHYAAAQGCLQAVQILCEHK-SPINLKDLDGNIPLLL---AVQNGHSEICHFL 174
Query: 724 QLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHG 783
L ++N++ +++G+TALMLA G + V+AL+ AD+N+ D G AL +
Sbjct: 175 -LDHGADVNSR-NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSE 232
Query: 784 HKEIAGLLLAVPSCDISL 801
+ I LLL+ S D L
Sbjct: 233 NAGIQSLLLSKISQDADL 250
Score = 47.0 bits (110), Expect = 7e-05
Identities = 34/109 (31%), Positives = 47/109 (43%), Gaps = 2/109 (1%)
Query: 718 DIETVLQLF-RLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTAL 776
D E V L + G K G+TA LA + G V+ ++ ++ DV QD G +AL
Sbjct: 34 DAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSAL 93
Query: 777 MCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
A ++ H E LL C D G TAL A G + +L
Sbjct: 94 HLAAKNSHHECIRKLLQ-SKCPAESVDSSGKTALHYAAAQGCLQAVQIL 141
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 67.4 bits (163), Expect = 5e-11
Identities = 46/165 (27%), Positives = 80/165 (48%), Gaps = 7/165 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
DS G TA H + + + ++ ++ GV V Q+ G+S + L A E +
Sbjct: 42 DSEGKTAFHLAAAKGHVECLRVMITHGV-DVTAQDTTGHSALHLAA-----KNSHHECIR 95
Query: 724 QLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHG 783
+L + +G+TAL A + G + V+ L ++ +N++D DG+ L+ A ++G
Sbjct: 96 KLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNG 155
Query: 784 HKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
H EI LL D++ ++ G TALM+A + G S L +
Sbjct: 156 HSEICHFLLD-HGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 199
Score = 47.4 bits (111), Expect = 6e-05
Identities = 44/138 (31%), Positives = 71/138 (51%), Gaps = 6/138 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
DS+G TALHY+ + VQ L + ++ ++ G P++L A +I L
Sbjct: 108 DSSGKTALHYAAAQGCLQAVQILCEHK-SPINLKDLDGNIPLLL---AVQNGHSEICHFL 163
Query: 724 QLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHG 783
L ++N++ +++G+TALMLA G + V+AL+ AD+N+ D G AL +
Sbjct: 164 -LDHGADVNSR-NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSE 221
Query: 784 HKEIAGLLLAVPSCDISL 801
+ I LLL+ S D L
Sbjct: 222 NAGIQSLLLSKISQDADL 239
Score = 47.0 bits (110), Expect = 7e-05
Identities = 34/109 (31%), Positives = 47/109 (43%), Gaps = 2/109 (1%)
Query: 718 DIETVLQLF-RLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTAL 776
D E V L + G K G+TA LA + G V+ ++ ++ DV QD G +AL
Sbjct: 23 DAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSAL 82
Query: 777 MCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
A ++ H E LL C D G TAL A G + +L
Sbjct: 83 HLAAKNSHHECIRKLLQ-SKCPAESVDSSGKTALHYAAAQGCLQAVQIL 130
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 67.4 bits (163), Expect = 5e-11
Identities = 46/165 (27%), Positives = 80/165 (48%), Gaps = 7/165 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
DS G TA H + + + ++ ++ GV V Q+ G+S + L A E +
Sbjct: 50 DSEGKTAFHLAAAKGHVECLRVMITHGV-DVTAQDTTGHSALHLAA-----KNSHHECIR 103
Query: 724 QLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHG 783
+L + +G+TAL A + G + V+ L ++ +N++D DG+ L+ A ++G
Sbjct: 104 KLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNG 163
Query: 784 HKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
H EI LL D++ ++ G TALM+A + G S L +
Sbjct: 164 HSEICHFLLD-HGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 207
Score = 47.4 bits (111), Expect = 6e-05
Identities = 44/138 (31%), Positives = 71/138 (51%), Gaps = 6/138 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
DS+G TALHY+ + VQ L + ++ ++ G P++L A +I L
Sbjct: 116 DSSGKTALHYAAAQGCLQAVQILCEHK-SPINLKDLDGNIPLLL---AVQNGHSEICHFL 171
Query: 724 QLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHG 783
L ++N++ +++G+TALMLA G + V+AL+ AD+N+ D G AL +
Sbjct: 172 -LDHGADVNSR-NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSE 229
Query: 784 HKEIAGLLLAVPSCDISL 801
+ I LLL+ S D L
Sbjct: 230 NAGIQSLLLSKISQDADL 247
Score = 47.0 bits (110), Expect = 7e-05
Identities = 34/109 (31%), Positives = 47/109 (43%), Gaps = 2/109 (1%)
Query: 718 DIETVLQLF-RLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTAL 776
D E V L + G K G+TA LA + G V+ ++ ++ DV QD G +AL
Sbjct: 31 DAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSAL 90
Query: 777 MCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
A ++ H E LL C D G TAL A G + +L
Sbjct: 91 HLAAKNSHHECIRKLLQ-SKCPAESVDSSGKTALHYAAAQGCLQAVQIL 138
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 67.4 bits (163), Expect = 5e-11
Identities = 46/165 (27%), Positives = 80/165 (48%), Gaps = 7/165 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
DS G TA H + + + ++ ++ GV V Q+ G+S + L A E +
Sbjct: 50 DSEGKTAFHLAAAKGHVECLRVMITHGV-DVTAQDTTGHSALHLAA-----KNSHHECIR 103
Query: 724 QLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHG 783
+L + +G+TAL A + G + V+ L ++ +N++D DG+ L+ A ++G
Sbjct: 104 KLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNG 163
Query: 784 HKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
H EI LL D++ ++ G TALM+A + G S L +
Sbjct: 164 HSEICHFLLD-HGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 207
Score = 47.4 bits (111), Expect = 6e-05
Identities = 44/138 (31%), Positives = 71/138 (51%), Gaps = 6/138 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
DS+G TALHY+ + VQ L + ++ ++ G P++L A +I L
Sbjct: 116 DSSGKTALHYAAAQGCLQAVQILCEHK-SPINLKDLDGNIPLLL---AVQNGHSEICHFL 171
Query: 724 QLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHG 783
L ++N++ +++G+TALMLA G + V+AL+ AD+N+ D G AL +
Sbjct: 172 -LDHGADVNSR-NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSE 229
Query: 784 HKEIAGLLLAVPSCDISL 801
+ I LLL+ S D L
Sbjct: 230 NAGIQSLLLSKISQDADL 247
Score = 47.0 bits (110), Expect = 7e-05
Identities = 34/109 (31%), Positives = 47/109 (43%), Gaps = 2/109 (1%)
Query: 718 DIETVLQLF-RLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTAL 776
D E V L + G K G+TA LA + G V+ ++ ++ DV QD G +AL
Sbjct: 31 DAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSAL 90
Query: 777 MCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
A ++ H E LL C D G TAL A G + +L
Sbjct: 91 HLAAKNSHHECIRKLLQ-SKCPAESVDSSGKTALHYAAAQGCLQAVQIL 138
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 67.4 bits (163), Expect = 5e-11
Identities = 46/165 (27%), Positives = 80/165 (48%), Gaps = 7/165 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
DS G TA H + + + ++ ++ GV V Q+ G+S + L A E +
Sbjct: 50 DSEGKTAFHLAAAKGHVECLRVMITHGV-DVTAQDTTGHSALHLAA-----KNSHHECIR 103
Query: 724 QLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHG 783
+L + +G+TAL A + G + V+ L ++ +N++D DG+ L+ A ++G
Sbjct: 104 KLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNG 163
Query: 784 HKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
H EI LL D++ ++ G TALM+A + G S L +
Sbjct: 164 HSEICHFLLD-HGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 207
Score = 47.4 bits (111), Expect = 6e-05
Identities = 44/138 (31%), Positives = 71/138 (51%), Gaps = 6/138 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
DS+G TALHY+ + VQ L + ++ ++ G P++L A +I L
Sbjct: 116 DSSGKTALHYAAAQGCLQAVQILCEHK-SPINLKDLDGNIPLLL---AVQNGHSEICHFL 171
Query: 724 QLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHG 783
L ++N++ +++G+TALMLA G + V+AL+ AD+N+ D G AL +
Sbjct: 172 -LDHGADVNSR-NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSE 229
Query: 784 HKEIAGLLLAVPSCDISL 801
+ I LLL+ S D L
Sbjct: 230 NAGIQSLLLSKISQDADL 247
Score = 47.0 bits (110), Expect = 7e-05
Identities = 34/109 (31%), Positives = 47/109 (43%), Gaps = 2/109 (1%)
Query: 718 DIETVLQLF-RLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTAL 776
D E V L + G K G+TA LA + G V+ ++ ++ DV QD G +AL
Sbjct: 31 DAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSAL 90
Query: 777 MCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
A ++ H E LL C D G TAL A G + +L
Sbjct: 91 HLAAKNSHHECIRKLLQ-SKCPAESVDSSGKTALHYAAAQGCLQAVQIL 138
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 67.4 bits (163), Expect = 5e-11
Identities = 46/165 (27%), Positives = 80/165 (48%), Gaps = 7/165 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
DS G TA H + + + ++ ++ GV V Q+ G+S + L A E +
Sbjct: 50 DSEGKTAFHLAAAKGHVECLRVMITHGV-DVTAQDTTGHSALHLAA-----KNSHHECIR 103
Query: 724 QLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHG 783
+L + +G+TAL A + G + V+ L ++ +N++D DG+ L+ A ++G
Sbjct: 104 KLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNG 163
Query: 784 HKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
H EI LL D++ ++ G TALM+A + G S L +
Sbjct: 164 HSEICHFLLD-HGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 207
Score = 47.4 bits (111), Expect = 6e-05
Identities = 44/138 (31%), Positives = 71/138 (51%), Gaps = 6/138 (4%)
Query: 664 DSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVL 723
DS+G TALHY+ + VQ L + ++ ++ G P++L A +I L
Sbjct: 116 DSSGKTALHYAAAQGCLQAVQILCEHK-SPINLKDLDGNIPLLL---AVQNGHSEICHFL 171
Query: 724 QLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHG 783
L ++N++ +++G+TALMLA G + V+AL+ AD+N+ D G AL +
Sbjct: 172 -LDHGADVNSR-NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSE 229
Query: 784 HKEIAGLLLAVPSCDISL 801
+ I LLL+ S D L
Sbjct: 230 NAGIQSLLLSKISQDADL 247
Score = 47.0 bits (110), Expect = 7e-05
Identities = 34/109 (31%), Positives = 47/109 (43%), Gaps = 2/109 (1%)
Query: 718 DIETVLQLF-RLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTAL 776
D E V L + G K G+TA LA + G V+ ++ ++ DV QD G +AL
Sbjct: 31 DAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSAL 90
Query: 777 MCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
A ++ H E LL C D G TAL A G + +L
Sbjct: 91 HLAAKNSHHECIRKLLQ-SKCPAESVDSSGKTALHYAAAQGCLQAVQIL 138
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 67.0 bits (162), Expect = 7e-11
Identities = 53/183 (28%), Positives = 86/183 (46%), Gaps = 18/183 (9%)
Query: 659 VVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLT---------- 708
VVN+AD T LH + + + + + LL G K+NR G +P+ L
Sbjct: 584 VVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPT-KKNRDGNTPLDLVKDGDTDIQDL 642
Query: 709 -----ALATLKTQDDIETVLQLFRLGNINAKASQAGQ-TALMLAVSHGRVDVVKALLACE 762
AL + + V +L N+N + +Q T L LA + ++V + LL
Sbjct: 643 LRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHG 702
Query: 763 ADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIA 822
ADVN QD G L A +GH ++A LL+ +C ++ TD+ T L A G++++
Sbjct: 703 ADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNAC-VNATDKWAFTPLHEAAQKGRTQLC 761
Query: 823 SML 825
++L
Sbjct: 762 ALL 764
Score = 57.8 bits (138), Expect = 4e-08
Identities = 59/183 (32%), Positives = 82/183 (44%), Gaps = 17/183 (9%)
Query: 644 HLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYS 703
HL T R + + D NI G TAL + VQQLL G+ G S
Sbjct: 445 HLQTCRLLLSYGCD--PNIISLQGFTALQMGNEN-----VQQLLQEGIS-------LGNS 490
Query: 704 PIMLTALATLKTQDDIETVLQLFRLGNINAKASQAGQ-TALMLAVSHGRVDVVKALLACE 762
L K D+ETV +L + ++N + + Q T L A + RV VV+ LL
Sbjct: 491 EADRQLLEAAKA-GDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHG 549
Query: 763 ADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIA 822
ADV+ +D G L AC +GH E+A LL+ +++ D T L A G+ EI
Sbjct: 550 ADVHAKDKGGLVPLHNACSYGHYEVAELLVK-HGAVVNVADLWKFTPLHEAAAKGKYEIC 608
Query: 823 SML 825
+L
Sbjct: 609 KLL 611
Score = 49.7 bits (117), Expect = 1e-05
Identities = 36/109 (33%), Positives = 54/109 (49%), Gaps = 2/109 (1%)
Query: 720 ETVLQLFRLGNINAKASQAGQ-TALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMC 778
E ++ L N+N AS + T L LA + RV +V+ LL ADV+ +D L
Sbjct: 191 EKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHN 250
Query: 779 ACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYS 827
AC +GH E+ LL+ +C ++ D T L A + E+ S+L S
Sbjct: 251 ACSYGHYEVTELLVKHGAC-VNAMDLWQFTPLHEAASKNRVEVCSLLLS 298
Score = 48.1 bits (113), Expect = 3e-05
Identities = 36/109 (33%), Positives = 52/109 (47%), Gaps = 2/109 (1%)
Query: 718 DIETVLQLFRLGNINAKASQAGQ-TALMLAVSHGRVDVVKALLACEADVNVQDDDGSTAL 776
D+E V +L +N++ + + T L A GR DVV+ LL A+V +DD G L
Sbjct: 36 DVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPL 95
Query: 777 MCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
AC GH E+ LLL D + D T L A G+ ++ +L
Sbjct: 96 HNACSFGHAEVVNLLLR-HGADPNARDNWNYTPLHEAAIKGKIDVCIVL 143
Score = 41.2 bits (95), Expect = 0.004
Identities = 33/89 (37%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 725 LFRLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHG 783
L R G NIN K + T L +A DVV+ ++ EA VN D+ G T+L A G
Sbjct: 386 LLRKGANINEKTKEF-LTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCG 444
Query: 784 HKEIAGLLLAVPSCDISLTDRDGSTALMV 812
H + LLL+ CD ++ G TAL +
Sbjct: 445 HLQTCRLLLSY-GCDPNIISLQGFTALQM 472
Score = 40.8 bits (94), Expect = 0.005
Identities = 47/176 (26%), Positives = 68/176 (38%), Gaps = 22/176 (12%)
Query: 660 VNIADSNG--NTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQD 717
VN D+ G +T LH++ VV+ LL +G V ++ G P L +
Sbjct: 49 VNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA-NVQARDDGGLIP-----LHNACSFG 102
Query: 718 DIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALM 777
E V L R G T L A G++DV LL A+ +++ DG TAL
Sbjct: 103 HAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALD 162
Query: 778 CACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKC 833
LA PS LT L+ + +G E L + +N+ C
Sbjct: 163 --------------LADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNC 204
Score = 37.7 bits (86), Expect = 0.045
Identities = 48/177 (27%), Positives = 74/177 (41%), Gaps = 14/177 (7%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSG----------VCKVDKQNRAGYSPIMLTA 709
+ + + N L +S N +QLL++ +C V N T
Sbjct: 470 LQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTP 529
Query: 710 LATLKTQDDIETVLQLFRLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQ 768
L + + V L + G +++AK + G L A S+G +V + L+ A VNV
Sbjct: 530 LHFAAGYNRVSVVEYLLQHGADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA 588
Query: 769 DDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
D T L A G EI LLL D + +RDG+T L + D G ++I +L
Sbjct: 589 DLWKFTPLHEAAAKGKYEICKLLLQ-HGADPTKKNRDGNTPLDLVKD-GDTDIQDLL 643
Score = 37.4 bits (85), Expect = 0.059
Identities = 59/247 (23%), Positives = 99/247 (40%), Gaps = 17/247 (6%)
Query: 591 SPDLISACLALEKYLDNPNALT---ERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVT 647
S + + C L Y +P L + + +A T L+E RLA H L
Sbjct: 286 SKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKE--RLAYEFKGHSLLQAAREAD 343
Query: 648 FRAMSARLLDYVVNIADSNGN-TALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIM 706
+ L +VN + TALH + + + +P +Q+ + + K N +
Sbjct: 344 VTRIKKHLSLEMVNFKHPQTHETALHCAAA-SPYPKRKQICELLLRKGANINEKTKEFLT 402
Query: 707 LTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVN 766
+A+ K +D+ V+ +NA GQT+L A G + + LL+ D N
Sbjct: 403 PLHVASEKAHNDVVEVVVKHE-AKVNA-LDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPN 460
Query: 767 VQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLY 826
+ G TAL + G++ + LL ISL + + L+ A AG E L
Sbjct: 461 IISLQGFTAL----QMGNENVQQLLQE----GISLGNSEADRQLLEAAKAGDVETVKKLC 512
Query: 827 SRMNIKC 833
+ ++ C
Sbjct: 513 TVQSVNC 519
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 66.2 bits (160), Expect = 1e-10
Identities = 54/182 (29%), Positives = 84/182 (46%), Gaps = 18/182 (9%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
VN+AD T LH + + + + + LL G K+NR G +P+ L QD +
Sbjct: 743 VNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPT-KKNRDGNTPLDLVKEGDTDIQDLL 801
Query: 720 E---------------TVLQLFRLGNINAKASQA-GQTALMLAVSHGRVDVVKALLACEA 763
V +L NIN + +Q T L LA + ++V + LL A
Sbjct: 802 RGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGA 861
Query: 764 DVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIAS 823
DVN QD G L A +GH +IA LL+ +C ++ TD+ T L A G++++ +
Sbjct: 862 DVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTC-VNATDKWAFTPLHEAAQKGRTQLCA 920
Query: 824 ML 825
+L
Sbjct: 921 LL 922
Score = 55.8 bits (133), Expect = 2e-07
Identities = 54/189 (28%), Positives = 79/189 (41%), Gaps = 26/189 (13%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLD----------SGVCKVDKQNRAGYSPIMLTA 709
+N D+ G TALH + + + LL G N A +L+
Sbjct: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQ--ILSE 641
Query: 710 LATLKTQD------------DIETVLQLFRLGNINAKASQAGQ-TALMLAVSHGRVDVVK 756
++T D D+ETV QL N+N + + T L A + RV VV+
Sbjct: 642 STPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVE 701
Query: 757 ALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDA 816
LL ADV+ +D G L AC +GH E+A LL+ +++ D T L A
Sbjct: 702 YLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVR-HGASVNVADLWKFTPLHEAAAK 760
Query: 817 GQSEIASML 825
G+ EI +L
Sbjct: 761 GKYEICKLL 769
Score = 53.9 bits (128), Expect = 6e-07
Identities = 55/183 (30%), Positives = 80/183 (43%), Gaps = 18/183 (9%)
Query: 661 NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIML---TALATLKTQD 717
N D+ T LH + V LL G + +N G S + L +A A L +
Sbjct: 276 NARDNWNYTPLHEAAIKGKIDVCIVLLQHGA-DPNIRNTDGKSALDLADPSAKAVLTGEY 334
Query: 718 DIETVLQLFRLGN------------INAKASQAGQ-TALMLAVSHGRVDVVKALLACEAD 764
+ +L+ R GN +N AS + T L LA + RV +V+ LL AD
Sbjct: 335 KKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD 394
Query: 765 VNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASM 824
V+ +D G L AC +GH E+ LLL +C ++ D T L A + E+ S+
Sbjct: 395 VHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC-VNAMDLWQFTPLHEAASKNRVEVCSL 453
Query: 825 LYS 827
L S
Sbjct: 454 LLS 456
Score = 52.8 bits (125), Expect = 1e-06
Identities = 39/110 (35%), Positives = 54/110 (49%), Gaps = 4/110 (3%)
Query: 718 DIETVLQLFRLGNINAKASQAGQTA--LMLAVSHGRVDVVKALLACEADVNVQDDDGSTA 775
D+ V +L N+NAK AG+ + L A GR DVV+ LL A+V+ +DD G
Sbjct: 194 DVSRVKRLVDAANVNAK-DMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIP 252
Query: 776 LMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
L AC GH E+ LLL D + D T L A G+ ++ +L
Sbjct: 253 LHNACSFGHAEVVSLLLC-QGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
Score = 49.3 bits (116), Expect = 2e-05
Identities = 142/620 (22%), Positives = 209/620 (33%), Gaps = 116/620 (18%)
Query: 301 QELQAAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLEPY 360
Q+LQ A A P P PPP SP + G AS A + R P
Sbjct: 16 QQLQPAPGASAPPPPP--PPPLSP------GLAPGTTPASPTASGLAPFASPRHGLALPE 67
Query: 361 GTGLRALAMPGRPESP-PVFRSQ--EVVETMCPV------PAAATSNVHMVKKISITERS 411
G G R P RP SP PV + T+C V PA +TS+ V S
Sbjct: 68 GDGSRD--PPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGS 125
Query: 412 CDGAAGLPEVPAESSSSPPGSEVASLTQPEKSTGRVPTQE-------PTHREPTRQAASQ 464
+ + P SSSS P S +SL + ++ G T P P A +
Sbjct: 126 -NNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALR 184
Query: 465 ESEEAGGTGGPPAGVRSIMKRKEEVADPTAHRRS--LQFVGVNGGYESSSEDSSTAENIS 522
E EA G + V+ ++ A A R+S L F G + N+
Sbjct: 185 ELLEA-CRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVH 243
Query: 523 DNDS-----TENEAPEPRERV----------PSVAEAPQLRPAGTAAAKTSRQECQLSRE 567
D N V P+ + P AA K C + +
Sbjct: 244 ARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 303
Query: 568 SQHIPTAEGASGSNTEEEIRMELSPDLISACLALE----KYLDNPNALTERELKVAYTTV 623
P NT+ + ++L+ A L E + L+ + E +L T
Sbjct: 304 HGADPNIR-----NTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP- 357
Query: 624 LQEWLRLACRSDAHPELVRRHLVT--FRAMSARLL---DYVVNIADSNGNTALHYSVSHA 678
L + C + + HL R +LL V+ D G LH + S+
Sbjct: 358 ----LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYG 413
Query: 679 NFPVVQQLLDSGVC-------------KVDKQNRAGYSPIMLT----------------- 708
++ V + LL G C + +NR ++L+
Sbjct: 414 HYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVD 473
Query: 709 ------------------ALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSH- 749
+L + D+ V + L IN K Q+ +TAL AV+
Sbjct: 474 MAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASL 533
Query: 750 --GRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGS 807
R V + LL A+VN ++ D T L A E H ++ +L ++ D G
Sbjct: 534 HPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVME-VLHKHGAKMNALDTLGQ 592
Query: 808 TALMVALDAGQSEIASMLYS 827
TAL A AG + +L S
Sbjct: 593 TALHRAALAGHLQTCRLLLS 612
Score = 38.1 bits (87), Expect = 0.035
Identities = 36/110 (32%), Positives = 52/110 (47%), Gaps = 2/110 (1%)
Query: 709 ALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQ 768
A+A+L + T L L + N+N K ++ T L +A DV++ L A +N
Sbjct: 529 AVASLHPKRKQVTELLLRKGANVNEK-NKDFMTPLHVAAERAHNDVMEVLHKHGAKMNAL 587
Query: 769 DDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQ 818
D G TAL A GH + LLL+ S D S+ G TA + +A Q
Sbjct: 588 DTLGQTALHRAALAGHLQTCRLLLSYGS-DPSIISLQGFTAAQMGNEAVQ 636
Score = 37.7 bits (86), Expect = 0.045
Identities = 38/156 (24%), Positives = 60/156 (38%), Gaps = 42/156 (26%)
Query: 660 VNIADSNG--NTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQD 717
+N D+ G +T LH + + N V + LL+ G V+ Q++ G P
Sbjct: 828 INCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGA-DVNAQDKGGLIP------------- 873
Query: 718 DIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALM 777
L A S+G VD+ L+ VN D T L
Sbjct: 874 -------------------------LHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLH 908
Query: 778 CACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVA 813
A + G ++ LLLA D ++ +++G T L +A
Sbjct: 909 EAAQKGRTQLCALLLA-HGADPTMKNQEGQTPLDLA 943
Score = 34.7 bits (78), Expect = 0.38
Identities = 32/96 (33%), Positives = 48/96 (50%), Gaps = 3/96 (3%)
Query: 730 NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAG 789
+++AK + G L A S+G +V + L+ A VNV D T L A G EI
Sbjct: 709 DVHAK-DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICK 767
Query: 790 LLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
LLL D + +RDG+T L + + G ++I +L
Sbjct: 768 LLLK-HGADPTKKNRDGNTPLDLVKE-GDTDIQDLL 801
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 65.9 bits (159), Expect = 2e-10
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 7/156 (4%)
Query: 673 YSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGNIN 732
++ + +V LL +G KV+ ++ G +P++ A + +E V L +G
Sbjct: 143 WAAGRGHADIVHLLLQNGA-KVNCSDKYGTTPLVWAA-----RKGHLECVKHLLAMGADV 196
Query: 733 AKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLL 792
+ TAL++AV G VK +L +VN+ D DG+TALM A + GH EI LL
Sbjct: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256
Query: 793 AVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
+ +++ DR G T L+ A+ G EI L +
Sbjct: 257 DAGTY-VNIPDRSGDTVLIGAVRGGHVEIVRALLQK 291
Score = 60.1 bits (144), Expect = 9e-09
Identities = 36/94 (38%), Positives = 55/94 (58%), Gaps = 5/94 (5%)
Query: 736 SQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVP 795
++ GQT LM+A G +++VK L+ A+ N++D D TAL+ A + GH I LL
Sbjct: 35 NECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELL--- 91
Query: 796 SCDISLTDRD--GSTALMVALDAGQSEIASMLYS 827
C ++L RD G TALM A G++++ +L S
Sbjct: 92 KCGVNLEHRDMGGWTALMWACYKGRTDVVELLLS 125
Score = 53.9 bits (128), Expect = 6e-07
Identities = 50/197 (25%), Positives = 81/197 (41%), Gaps = 30/197 (15%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQN-----------RAGYSPIML- 707
VN +D G T L ++ + V+ LL G VD++ + GY+ +
Sbjct: 163 VNCSDKYGTTPLVWAARKGHLECVKHLLAMGA-DVDQEGANSMTALIVAVKGGYTQSVKE 221
Query: 708 ----------------TALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGR 751
TAL + E V L G ++G T L+ AV G
Sbjct: 222 ILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGH 281
Query: 752 VDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALM 811
V++V+ALL AD++++ D TAL A E G+ + +L + D + +DG T L+
Sbjct: 282 VEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQC-NPDTEICTKDGETPLI 340
Query: 812 VALDAGQSEIASMLYSR 828
A E+ +L +
Sbjct: 341 KATKMRNIEVVELLLDK 357
Score = 52.8 bits (125), Expect = 1e-06
Identities = 53/200 (26%), Positives = 86/200 (43%), Gaps = 44/200 (22%)
Query: 661 NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIE 720
N+ D + TAL + + +V++LL GV ++ ++ G++ +M A K + D+
Sbjct: 65 NLEDLDNWTALISASKEGHVHIVEELLKCGV-NLEHRDMGGWTALMW---ACYKGRTDVV 120
Query: 721 TVLQLFRLGNINAKASQAGQTA---LMLAVSHGRVDVVKALLACEADVNVQDDDGSTALM 777
+L + A S G + ++ A G D+V LL A VN D G+T L+
Sbjct: 121 ELLL-----SHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLV 175
Query: 778 CACEHGHKEIAGLLLAV--------------------------------PSCDISLTDRD 805
A GH E LLA+ + +++LTD+D
Sbjct: 176 WAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKD 235
Query: 806 GSTALMVALDAGQSEIASML 825
G+TALM+A G +EI L
Sbjct: 236 GNTALMIASKEGHTEIVQDL 255
Score = 52.4 bits (124), Expect = 2e-06
Identities = 47/174 (27%), Positives = 78/174 (44%), Gaps = 11/174 (6%)
Query: 655 LLDYVVNIADSN--GNTALHYSVSHANFPVVQQLLDSGV-CKVDKQNRAGYSPIMLTALA 711
LL+ ++ + N G T L + N +V++L+ +G C ++ + TAL
Sbjct: 24 LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDN-------WTALI 76
Query: 712 TLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDD 771
+ + + V +L + G G TALM A GR DVV+ LL+ A+ +V
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
Query: 772 GSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
++ A GH +I LLL ++ +D+ G+T L+ A G E L
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQ-NGAKVNCSDKYGTTPLVWAARKGHLECVKHL 189
Score = 43.1 bits (100), Expect = 0.001
Identities = 44/163 (26%), Positives = 68/163 (41%), Gaps = 27/163 (16%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSG--VCKVDKQN--------RAGYSPIMLTA 709
VN+ D +GNTAL + + +VQ LLD+G V D+ R G+ I+
Sbjct: 229 VNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRAL 288
Query: 710 LAT-----LKTQDDIETVLQLFRLGNINAK------------ASQAGQTALMLAVSHGRV 752
L ++ QD+ + GN ++ G+T L+ A +
Sbjct: 289 LQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNI 348
Query: 753 DVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVP 795
+VV+ LL A V+ D G T L A +++A LLL P
Sbjct: 349 EVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNP 391
Score = 36.6 bits (83), Expect = 0.10
Identities = 27/79 (34%), Positives = 38/79 (48%), Gaps = 1/79 (1%)
Query: 747 VSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDG 806
V + +KALL DV+ +++ G T LM A E G+ EI L+ + +L D D
Sbjct: 13 VEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIK-NGANCNLEDLDN 71
Query: 807 STALMVALDAGQSEIASML 825
TAL+ A G I L
Sbjct: 72 WTALISASKEGHVHIVEEL 90
>gi|115495445 ankyrin repeat domain 30A [Homo sapiens]
Length = 1341
Score = 65.5 bits (158), Expect = 2e-10
Identities = 48/133 (36%), Positives = 72/133 (54%), Gaps = 12/133 (9%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
+N+ D GNTALHY+V VV +LL G ++ N+A +P++L+ T +++ +
Sbjct: 76 INLVDVYGNTALHYAVYSEILSVVAKLLSHGAV-IEVHNKASLTPLLLS--ITKRSEQIV 132
Query: 720 ETVLQLFRLGNINAKA-SQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGST---- 774
E +L + N NA A ++ TALMLAV HG ++V LL DV D G T
Sbjct: 133 EFLL----IKNANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHY 188
Query: 775 ALMCACEHGHKEI 787
A+ C H H++I
Sbjct: 189 AVTCGFHHIHEQI 201
Score = 49.7 bits (117), Expect = 1e-05
Identities = 51/195 (26%), Positives = 82/195 (42%), Gaps = 30/195 (15%)
Query: 651 MSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIML--- 707
M+ R +NI D+ TALH++ + + VV L+D C++D + +P+M
Sbjct: 1 MTKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDR-KCQLDVLDGEHRTPLMKALQ 59
Query: 708 -------------------------TALATLKTQDDIETVLQLFRLGNINAKASQAGQTA 742
TAL + + V +L G + ++A T
Sbjct: 60 CHQEACANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTP 119
Query: 743 LMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLT 802
L+L+++ +V+ LL A+ N + TALM A HG EI G+LL + D+
Sbjct: 120 LLLSITKRSEQIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEIVGMLLQ-QNVDVFAA 178
Query: 803 DRDGSTALMVALDAG 817
D G TA A+ G
Sbjct: 179 DICGVTAEHYAVTCG 193
Score = 40.0 bits (92), Expect = 0.009
Identities = 22/62 (35%), Positives = 34/62 (54%), Gaps = 1/62 (1%)
Query: 764 DVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIAS 823
++N+QD TAL AC +GH+E+ L+ C + + D + T LM AL Q A+
Sbjct: 9 NLNIQDAQKRTALHWACVNGHEEVVTFLVD-RKCQLDVLDGEHRTPLMKALQCHQEACAN 67
Query: 824 ML 825
+L
Sbjct: 68 IL 69
Score = 38.5 bits (88), Expect = 0.027
Identities = 33/96 (34%), Positives = 52/96 (54%), Gaps = 5/96 (5%)
Query: 730 NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAG 789
N+N + +Q +TAL A +G +VV L+ + ++V D + T LM A + H+E
Sbjct: 9 NLNIQDAQK-RTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQC-HQEACA 66
Query: 790 LLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
+L DI+L D G+TAL A+ SEI S++
Sbjct: 67 NILIDSGADINLVDVYGNTALHYAV---YSEILSVV 99
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 65.1 bits (157), Expect = 3e-10
Identities = 53/199 (26%), Positives = 93/199 (46%), Gaps = 7/199 (3%)
Query: 633 RSDAHPELVRRHLVTFRAM--SARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSG 690
R+ H H+ A+ SA +D AD++G TALH++ + + V+ LL+
Sbjct: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 779
Query: 691 VCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHG 750
V + + N +SP+ + + E ++ +NA S+ G+T L A
Sbjct: 780 VFQKTEGN--AFSPLHCAVIND--NEGAAEMLIDTLGASIVNATDSK-GRTPLHAAAFTD 834
Query: 751 RVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTAL 810
V+ ++ LL+ A VN D G T LM A E+G +L++ S +++L D +TAL
Sbjct: 835 HVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTAL 894
Query: 811 MVALDAGQSEIASMLYSRM 829
+A G A ++ ++
Sbjct: 895 HLACSKGHETSALLILEKI 913
Score = 57.8 bits (138), Expect = 4e-08
Identities = 48/175 (27%), Positives = 85/175 (48%), Gaps = 8/175 (4%)
Query: 655 LLDYVVNIADSN--GNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALAT 712
LLD V++ + N GNT LH + + VV +L+D G V+++N G++P+ A +T
Sbjct: 225 LLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAI-VNQKNEKGFTPLHFAAAST 283
Query: 713 LKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDG 772
+ L + ++N K S+ G+T L + HGR + ++ A ++ +D +G
Sbjct: 284 ---HGALCLELLVGNGADVNMK-SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNG 339
Query: 773 STALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYS 827
+T L A +GH+ + L+ D + G L +A +G S+ L S
Sbjct: 340 NTPLHIAARYGHELLINTLI-TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS 393
Score = 57.4 bits (137), Expect = 6e-08
Identities = 48/175 (27%), Positives = 80/175 (45%), Gaps = 7/175 (4%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
+N D A+H++ + VV+ L+ G +V +++ Y+P+ A + + I
Sbjct: 166 INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA-EVTCKDKKSYTPLHAAASSGM-----I 219
Query: 720 ETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCA 779
V L LG + + G T L +A +G+ VV L+ C A VN +++ G T L A
Sbjct: 220 SVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFA 279
Query: 780 CEHGHKEIAGLLLAVPSCDISLTDRDGSTAL-MVALDAGQSEIASMLYSRMNIKC 833
H + LL D+++ +DG T L M AL S +++ S I C
Sbjct: 280 AASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDC 334
Score = 52.8 bits (125), Expect = 1e-06
Identities = 44/154 (28%), Positives = 66/154 (42%), Gaps = 7/154 (4%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
VN+ +G T LH + H F Q ++ SG +D +++ G +P+ + A +
Sbjct: 299 VNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAV-IDCEDKNGNTPLHIAARYGHEL---- 353
Query: 720 ETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCA 779
+ L G AK G L LA G D + LL+ D++ DD G T L A
Sbjct: 354 -LINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAA 412
Query: 780 CEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVA 813
G+ E LLL D + D+ G + L A
Sbjct: 413 AAGGNLECLNLLLNT-GADFNKKDKFGRSPLHYA 445
Score = 50.8 bits (120), Expect = 5e-06
Identities = 44/168 (26%), Positives = 84/168 (50%), Gaps = 7/168 (4%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
VN D+ T LH + + +++ L+ SG +V+ ++ +P+ + +++ +
Sbjct: 34 VNFQDNEKRTPLHAAAYLGDAEIIELLILSGA-RVNAKDSKWLTPLHRAVASC--SEEAV 90
Query: 720 ETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCA 779
+ +L+ ++NA+ + QT L +A ++ V +AL+ ++VNV D G TAL A
Sbjct: 91 QVLLK--HSADVNAR-DKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHA 147
Query: 780 CEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYS 827
GH E+ LLL+ +I+ D+ A+ A G E+ +L S
Sbjct: 148 AFSGHGEMVKLLLS-RGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 194
Score = 46.6 bits (109), Expect = 1e-04
Identities = 53/210 (25%), Positives = 85/210 (40%), Gaps = 5/210 (2%)
Query: 616 LKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSV 675
++ + T +L + A S H H + LLD +++ +S+G T L +
Sbjct: 534 METSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLD--LDVRNSSGRTPLDLAA 591
Query: 676 SHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGNINAKA 735
+ V L++ G + K +PI A AT + + ++ N
Sbjct: 592 FKGHVECVDVLINQGASILVKDYILKRTPIH--AAATNGHSECLRLLIGNAEPQNAVDIQ 649
Query: 736 SQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVP 795
GQT LML+V +G D V +LL A+V+ +D G TAL GH+E LL
Sbjct: 650 DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQ-H 708
Query: 796 SCDISLTDRDGSTALMVALDAGQSEIASML 825
L D G T + ++ G + L
Sbjct: 709 GAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738
Score = 43.9 bits (102), Expect = 6e-04
Identities = 38/112 (33%), Positives = 58/112 (51%), Gaps = 3/112 (2%)
Query: 718 DIETVLQLFRLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTAL 776
D E + L G +NAK S+ T L AV+ + V+ LL ADVN +D + T L
Sbjct: 53 DAEIIELLILSGARVNAKDSK-WLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPL 111
Query: 777 MCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
A + + A L+ + S +++++DR G TAL A +G E+ +L SR
Sbjct: 112 HIAAANKAVKCAEALVPLLS-NVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 162
Score = 40.8 bits (94), Expect = 0.005
Identities = 44/163 (26%), Positives = 72/163 (44%), Gaps = 12/163 (7%)
Query: 669 TALHYSVSHANFPVVQQLLDSGVCK--VDKQNRAGYSPIMLTALATLKTQDDIETVLQLF 726
T +H + ++ + ++ L+ + + VD Q+ G +P+ML+ L + V L
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVL-----NGHTDCVYSLL 673
Query: 727 RLG-NINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHK 785
G N++AK + G+TAL G + V ALL A ++D G T + + GH
Sbjct: 674 NKGANVDAK-DKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHI 732
Query: 786 EIAGLLL---AVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
+ G LL A + + D G TAL A G +L
Sbjct: 733 GVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775
Score = 39.3 bits (90), Expect = 0.016
Identities = 30/140 (21%), Positives = 61/140 (43%), Gaps = 7/140 (5%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTA-------LAT 712
VN D G T LHY+ + + L +++ GY+ + +A L
Sbjct: 464 VNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQL 523
Query: 713 LKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDG 772
+ ++ ++ +++ ++ ++A + L LA HG ++ L+ D++V++ G
Sbjct: 524 IASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSG 583
Query: 773 STALMCACEHGHKEIAGLLL 792
T L A GH E +L+
Sbjct: 584 RTPLDLAAFKGHVECVDVLI 603
Score = 36.6 bits (83), Expect = 0.10
Identities = 27/86 (31%), Positives = 43/86 (50%), Gaps = 1/86 (1%)
Query: 740 QTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDI 799
Q +L+ A+ +G D V+AL+ + DVN QD++ T L A G EI LL+ + +
Sbjct: 9 QPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI-LSGARV 67
Query: 800 SLTDRDGSTALMVALDAGQSEIASML 825
+ D T L A+ + E +L
Sbjct: 68 NAKDSKWLTPLHRAVASCSEEAVQVL 93
>gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain
containing 1 [Homo sapiens]
Length = 475
Score = 64.7 bits (156), Expect = 3e-10
Identities = 60/183 (32%), Positives = 90/183 (49%), Gaps = 15/183 (8%)
Query: 655 LLDYVVNIADSN---GNTALHYSVSHANFPVVQQLLDSGV---CKVDKQNRAGYSPIMLT 708
LLD +++ DSN G T L Y+ S AN +V+ LLD G + DKQ+ I++T
Sbjct: 65 LLDSGISV-DSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQS------ILIT 117
Query: 709 ALATLKTQDDIETVLQLFRLGNINAK-ASQAGQTALMLAVSHGRVDVVKALLACEADVNV 767
A + +++ I ++L N + A + T +M A G VV L+A A+VN
Sbjct: 118 ACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNT 177
Query: 768 QDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYS 827
QD++G TAL A GHK I LL + + L +DG +A EI ++L
Sbjct: 178 QDENGYTALTWAARQGHKNIVLKLLEL-GANKMLQTKDGKMPSEIAKRNKHHEIFNLLSF 236
Query: 828 RMN 830
+N
Sbjct: 237 TLN 239
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 64.3 bits (155), Expect = 5e-10
Identities = 50/169 (29%), Positives = 83/169 (49%), Gaps = 7/169 (4%)
Query: 660 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDI 719
V+ DS+G T L + + V++L+ G ++ Q +G TAL Q
Sbjct: 39 VDCRDSHGTTLLMVAAYAGHIDCVRELVLQGA-DINLQRESG-----TTALFFAAQQGHN 92
Query: 720 ETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCA 779
+ V LF G ++ G TAL+ A +G + VV+ LL A+++ Q DG+TAL A
Sbjct: 93 DVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLA 152
Query: 780 CEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSR 828
+ G+ ++ LLLA ++ +DG+ L +A G SE+ ++ R
Sbjct: 153 AQGGYLDVIRLLLA-SGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLR 200
Score = 44.3 bits (103), Expect = 5e-04
Identities = 43/161 (26%), Positives = 75/161 (46%), Gaps = 10/161 (6%)
Query: 666 NGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQL 725
+G TAL + + + VV+ LL G + Q G + + L A ++ + L
Sbjct: 111 DGGTALLAASQYGHMQVVETLLKHGA-NIHDQLYDGATALFLAAQGGY-----LDVIRLL 164
Query: 726 FRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHK 785
G + Q G L +A G +VV+ +L AD + +DG+TAL+ A G+
Sbjct: 165 LASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYN 224
Query: 786 E-IAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASML 825
+ I LL P+ I ++G++AL A+ +G + ++L
Sbjct: 225 DVIKELLKFSPTLGIL---KNGTSALHAAVLSGNIKTVALL 262
Score = 42.0 bits (97), Expect = 0.002
Identities = 41/140 (29%), Positives = 64/140 (45%), Gaps = 9/140 (6%)
Query: 655 LLDYVVNIADS--NGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALAT 712
LL + NI D +G TAL + V++ LL SG KV++ + G +P+ + +
Sbjct: 131 LLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGA-KVNQPRQDGTAPLWIAS--- 186
Query: 713 LKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDG 772
E V + G A G TAL+ A + G DV+K LL + + +G
Sbjct: 187 --QMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNG 243
Query: 773 STALMCACEHGHKEIAGLLL 792
++AL A G+ + LLL
Sbjct: 244 TSALHAAVLSGNIKTVALLL 263
Score = 41.2 bits (95), Expect = 0.004
Identities = 27/86 (31%), Positives = 43/86 (50%), Gaps = 2/86 (2%)
Query: 742 ALMLAVSHGRVDVVKALL-ACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDIS 800
A A G + ++K LL + DV+ +D G+T LM A GH + L+ + DI+
Sbjct: 15 AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV-LQGADIN 73
Query: 801 LTDRDGSTALMVALDAGQSEIASMLY 826
L G+TAL A G +++ L+
Sbjct: 74 LQRESGTTALFFAAQQGHNDVVRFLF 99
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,981,668
Number of Sequences: 37866
Number of extensions: 1949345
Number of successful extensions: 16219
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 309
Number of HSP's successfully gapped in prelim test: 544
Number of HSP's that attempted gapping in prelim test: 12464
Number of HSP's gapped (non-prelim): 3678
length of query: 851
length of database: 18,247,518
effective HSP length: 111
effective length of query: 740
effective length of database: 14,044,392
effective search space: 10392850080
effective search space used: 10392850080
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.