Guide to the Human Genome
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Search of human proteins with 31317249

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31317249 interleukin 6 receptor isoform 2 precursor [Homo
sapiens]
         (365 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31317249 interleukin 6 receptor isoform 2 precursor [Homo sap...   759   0.0  
gi|4504673 interleukin 6 receptor isoform 1 precursor [Homo sapi...   739   0.0  
gi|218505839 interleukin 11 receptor, alpha isoform 1 precursor ...   119   3e-27
gi|22212922 interleukin 11 receptor, alpha isoform 2 precursor [...   119   3e-27
gi|4758594 interleukin 11 receptor, alpha isoform 1 precursor [H...   119   3e-27
gi|22212918 ciliary neurotrophic factor receptor preproprotein [...   105   6e-23
gi|4502931 ciliary neurotrophic factor receptor preproprotein [H...   105   6e-23
gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]              67   3e-11
gi|24497438 interleukin 12B precursor [Homo sapiens]                   65   1e-10
gi|28610149 interleukin 6 signal transducer isoform 2 precursor ...    58   2e-08
gi|28610147 interleukin 6 signal transducer isoform 1 precursor ...    58   2e-08
gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]    55   1e-07
gi|4506107 prolactin receptor [Homo sapiens]                           51   1e-06
gi|14577917 Epstein-Barr virus induced 3 precursor [Homo sapiens]      50   2e-06
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42...    45   1e-04
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa...    45   1e-04
gi|51093381 leptin receptor isoform 3 [Homo sapiens]                   41   0.002
gi|51093379 leptin receptor isoform 2 [Homo sapiens]                   41   0.002
gi|40254464 leptin receptor isoform 1 [Homo sapiens]                   41   0.002
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                    40   0.003
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                    40   0.003
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                    40   0.003
gi|115430248 gp130-like monocyte receptor [Homo sapiens]               40   0.003
gi|110349719 titin isoform N2-A [Homo sapiens]                         40   0.004
gi|110349717 titin isoform novex-2 [Homo sapiens]                      40   0.004
gi|110349713 titin isoform novex-1 [Homo sapiens]                      40   0.004
gi|110349715 titin isoform N2-B [Homo sapiens]                         40   0.004
gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Ho...    39   0.010
gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Ho...    39   0.010
gi|169214048 PREDICTED: hypothetical protein [Homo sapiens]            37   0.021

>gi|31317249 interleukin 6 receptor isoform 2 precursor [Homo
           sapiens]
          Length = 365

 Score =  759 bits (1961), Expect = 0.0
 Identities = 365/365 (100%), Positives = 365/365 (100%)

Query: 1   MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW 60
           MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW
Sbjct: 1   MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW 60

Query: 61  VLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS 120
           VLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS
Sbjct: 61  VLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS 120

Query: 121 CFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAV 180
           CFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAV
Sbjct: 121 CFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAV 180

Query: 181 PEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQD 240
           PEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQD
Sbjct: 181 PEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQD 240

Query: 241 PHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ 300
           PHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ
Sbjct: 241 PHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ 300

Query: 301 GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPGSRRR 360
           GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPGSRRR
Sbjct: 301 GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPGSRRR 360

Query: 361 GSCGL 365
           GSCGL
Sbjct: 361 GSCGL 365


>gi|4504673 interleukin 6 receptor isoform 1 precursor [Homo
           sapiens]
          Length = 468

 Score =  739 bits (1907), Expect = 0.0
 Identities = 355/355 (100%), Positives = 355/355 (100%)

Query: 1   MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW 60
           MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW
Sbjct: 1   MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW 60

Query: 61  VLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS 120
           VLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS
Sbjct: 61  VLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS 120

Query: 121 CFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAV 180
           CFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAV
Sbjct: 121 CFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAV 180

Query: 181 PEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQD 240
           PEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQD
Sbjct: 181 PEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQD 240

Query: 241 PHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ 300
           PHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ
Sbjct: 241 PHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ 300

Query: 301 GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLP 355
           GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLP
Sbjct: 301 GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLP 355


>gi|218505839 interleukin 11 receptor, alpha isoform 1 precursor
           [Homo sapiens]
          Length = 422

 Score =  119 bits (299), Expect = 3e-27
 Identities = 102/329 (31%), Positives = 143/329 (43%), Gaps = 26/329 (7%)

Query: 2   LAVGCALLAALLAAPGAAL--APRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVH 59
           ++  C+ L+ +L A   AL  A   CP      GV    PG SV L CPGV   D   V 
Sbjct: 1   MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGD--PVS 58

Query: 60  WVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRA-GRPAGTVHLLVDVPPEEP 117
           W    +P     P   +G+G  L+L      D G Y C    G   GTV L +  PP  P
Sbjct: 59  WFRDGEPKLLQGPD--SGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARP 116

Query: 118 QLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQE-------PCQYSQE 170
            +SC + +   N  C W P     L T+ +   RK     A+  +        PC     
Sbjct: 117 VVSC-QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCP---- 171

Query: 171 SQKFSCQLAVPEGDS--SFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVA 228
                    V  G    S Y +++   + +G+  ++        IL+PDPP  + V +V 
Sbjct: 172 QDPLGAARCVVHGAEFWSQYRINVTEVNPLGAS-TRLLDVSLQSILRPDPPQGLRVESVP 230

Query: 229 RNPRWLSVTWQDPHSWNSS-FYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLR 287
             PR L  +W  P SW     + L+F L+YR  +   ++T     L+   VI DA +GL 
Sbjct: 231 GYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEE--VITDAVAGLP 288

Query: 288 HVVQLRAQEEFGQGEWSEWSPEAMGTPWT 316
           H V++ A++    G WS WSPEA GTP T
Sbjct: 289 HAVRVSARDFLDAGTWSTWSPEAWGTPST 317


>gi|22212922 interleukin 11 receptor, alpha isoform 2 precursor
           [Homo sapiens]
          Length = 390

 Score =  119 bits (299), Expect = 3e-27
 Identities = 102/329 (31%), Positives = 143/329 (43%), Gaps = 26/329 (7%)

Query: 2   LAVGCALLAALLAAPGAAL--APRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVH 59
           ++  C+ L+ +L A   AL  A   CP      GV    PG SV L CPGV   D   V 
Sbjct: 1   MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGD--PVS 58

Query: 60  WVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRA-GRPAGTVHLLVDVPPEEP 117
           W    +P     P   +G+G  L+L      D G Y C    G   GTV L +  PP  P
Sbjct: 59  WFRDGEPKLLQGPD--SGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARP 116

Query: 118 QLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQE-------PCQYSQE 170
            +SC + +   N  C W P     L T+ +   RK     A+  +        PC     
Sbjct: 117 VVSC-QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCP---- 171

Query: 171 SQKFSCQLAVPEGDS--SFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVA 228
                    V  G    S Y +++   + +G+  ++        IL+PDPP  + V +V 
Sbjct: 172 QDPLGAARCVVHGAEFWSQYRINVTEVNPLGAS-TRLLDVSLQSILRPDPPQGLRVESVP 230

Query: 229 RNPRWLSVTWQDPHSWNSS-FYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLR 287
             PR L  +W  P SW     + L+F L+YR  +   ++T     L+   VI DA +GL 
Sbjct: 231 GYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEE--VITDAVAGLP 288

Query: 288 HVVQLRAQEEFGQGEWSEWSPEAMGTPWT 316
           H V++ A++    G WS WSPEA GTP T
Sbjct: 289 HAVRVSARDFLDAGTWSTWSPEAWGTPST 317


>gi|4758594 interleukin 11 receptor, alpha isoform 1 precursor [Homo
           sapiens]
          Length = 422

 Score =  119 bits (299), Expect = 3e-27
 Identities = 102/329 (31%), Positives = 143/329 (43%), Gaps = 26/329 (7%)

Query: 2   LAVGCALLAALLAAPGAAL--APRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVH 59
           ++  C+ L+ +L A   AL  A   CP      GV    PG SV L CPGV   D   V 
Sbjct: 1   MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGD--PVS 58

Query: 60  WVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRA-GRPAGTVHLLVDVPPEEP 117
           W    +P     P   +G+G  L+L      D G Y C    G   GTV L +  PP  P
Sbjct: 59  WFRDGEPKLLQGPD--SGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARP 116

Query: 118 QLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQE-------PCQYSQE 170
            +SC + +   N  C W P     L T+ +   RK     A+  +        PC     
Sbjct: 117 VVSC-QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCP---- 171

Query: 171 SQKFSCQLAVPEGDS--SFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVA 228
                    V  G    S Y +++   + +G+  ++        IL+PDPP  + V +V 
Sbjct: 172 QDPLGAARCVVHGAEFWSQYRINVTEVNPLGAS-TRLLDVSLQSILRPDPPQGLRVESVP 230

Query: 229 RNPRWLSVTWQDPHSWNSS-FYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLR 287
             PR L  +W  P SW     + L+F L+YR  +   ++T     L+   VI DA +GL 
Sbjct: 231 GYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEE--VITDAVAGLP 288

Query: 288 HVVQLRAQEEFGQGEWSEWSPEAMGTPWT 316
           H V++ A++    G WS WSPEA GTP T
Sbjct: 289 HAVRVSARDFLDAGTWSTWSPEAWGTPST 317


>gi|22212918 ciliary neurotrophic factor receptor preproprotein
           [Homo sapiens]
          Length = 372

 Score =  105 bits (262), Expect = 6e-23
 Identities = 106/358 (29%), Positives = 153/358 (42%), Gaps = 32/358 (8%)

Query: 11  ALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSH 70
           A+LAA  A +  +R   QE        L G  VTL C G    D A V W +     G+ 
Sbjct: 11  AVLAAAAAVVYAQRHSPQEAPHVQYERL-GSDVTLPC-GTANWD-AAVTWRVN----GTD 63

Query: 71  PSRWAGMGRRLLLRSVQLHDSGNYSCYR--AGRPAGTVHLLVDVPPEEPQLSCFRKSPLS 128
            +     G +L+L  ++L  SG Y+C+   +      V L V +PP EP LSC   +   
Sbjct: 64  LAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPK 123

Query: 129 NVVCEWG---PRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDS 185
              C W    P   P+     VL   K            C+    + K  C +      S
Sbjct: 124 GFYCSWHLPTPTYIPNTFNVTVLHGSKIM---------VCE-KDPALKNRCHIRYMHLFS 173

Query: 186 SF-YIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSW 244
           +  Y VS+ V++++G   +   TF    I++PDPP N+    V  NPR L VTWQ P +W
Sbjct: 174 TIKYKVSISVSNALGHNATAI-TFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTW 232

Query: 245 -NSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEW 303
            +   + L+F LRYR      +    + D   H  I DA++G  +++Q+ A++    G W
Sbjct: 233 PDPESFPLKFFLRYRPLILDQWQHVELSDGTAH-TITDAYAGKEYIIQVAAKDN-EIGTW 290

Query: 304 SEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPGSRRRG 361
           S+WS  A  TPWTE         ++T  QA  T     + L          PG    G
Sbjct: 291 SDWSVAAHATPWTEE-----PRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSG 343


>gi|4502931 ciliary neurotrophic factor receptor preproprotein [Homo
           sapiens]
          Length = 372

 Score =  105 bits (262), Expect = 6e-23
 Identities = 106/358 (29%), Positives = 153/358 (42%), Gaps = 32/358 (8%)

Query: 11  ALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSH 70
           A+LAA  A +  +R   QE        L G  VTL C G    D A V W +     G+ 
Sbjct: 11  AVLAAAAAVVYAQRHSPQEAPHVQYERL-GSDVTLPC-GTANWD-AAVTWRVN----GTD 63

Query: 71  PSRWAGMGRRLLLRSVQLHDSGNYSCYR--AGRPAGTVHLLVDVPPEEPQLSCFRKSPLS 128
            +     G +L+L  ++L  SG Y+C+   +      V L V +PP EP LSC   +   
Sbjct: 64  LAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPK 123

Query: 129 NVVCEWG---PRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDS 185
              C W    P   P+     VL   K            C+    + K  C +      S
Sbjct: 124 GFYCSWHLPTPTYIPNTFNVTVLHGSKIM---------VCE-KDPALKNRCHIRYMHLFS 173

Query: 186 SF-YIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSW 244
           +  Y VS+ V++++G   +   TF    I++PDPP N+    V  NPR L VTWQ P +W
Sbjct: 174 TIKYKVSISVSNALGHNATAI-TFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTW 232

Query: 245 -NSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEW 303
            +   + L+F LRYR      +    + D   H  I DA++G  +++Q+ A++    G W
Sbjct: 233 PDPESFPLKFFLRYRPLILDQWQHVELSDGTAH-TITDAYAGKEYIIQVAAKDN-EIGTW 290

Query: 304 SEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPGSRRRG 361
           S+WS  A  TPWTE         ++T  QA  T     + L          PG    G
Sbjct: 291 SDWSVAAHATPWTEE-----PRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSG 343


>gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]
          Length = 422

 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 84/335 (25%), Positives = 126/335 (37%), Gaps = 32/335 (9%)

Query: 9   LAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTC------PGVEPEDNATVHWVL 62
           L  LL   GA  A        ++    T L G S+  TC      PG   E    ++W L
Sbjct: 22  LLLLLCVLGAPRAGSGAHTAVISPQDPTLLIGSSLLATCSVHGDPPGATAEG---LYWTL 78

Query: 63  RKPAAGSHPSRWAGMGRRLL----LRSVQLHDSGNYSCY-RAGRPAGTVHLLVDVPPEEP 117
                    SR        L    L   +     N  C+ R G       L V +PPE+P
Sbjct: 79  NGRRLPPELSRVLNASTLALALANLNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKP 138

Query: 118 -QLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSC 176
             +SC+ K+ + ++ C W P +           ++       +D    C+        SC
Sbjct: 139 VNISCWSKN-MKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQD--NTCEEYHTVGPHSC 195

Query: 177 QLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSV 236
            +       + Y + +   + +GS  S   T     ++  DPP ++ V+ V      LSV
Sbjct: 196 HIPKDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSV 255

Query: 237 TWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKD---LQHHCVIHDAWSGLRHVVQLR 293
            W  P +     ++ ++++RYR E S     W V D    Q  C +     G  + VQ+R
Sbjct: 256 RWVSPPALKDFLFQAKYQIRYRVEDS---VDWKVVDDVSNQTSCRLAGLKPGTVYFVQVR 312

Query: 294 AQEEFG------QGEWSEWS-PEAMGTPWTESRSP 321
               FG       G WSEWS P A  TP +E   P
Sbjct: 313 C-NPFGIYGSKKAGIWSEWSHPTAASTPRSERPGP 346


>gi|24497438 interleukin 12B precursor [Homo sapiens]
          Length = 328

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 77/329 (23%), Positives = 128/329 (38%), Gaps = 55/329 (16%)

Query: 13  LAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPS 72
           LA+P  A+   +     V        PG+ V LTC   E ED  T  W L         S
Sbjct: 16  LASPLVAIWELKKDVYVVELDWYPDAPGEMVVLTCDTPE-EDGIT--WTL------DQSS 66

Query: 73  RWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLV----------DV------PPEE 116
              G G+ L ++  +  D+G Y+C++ G       LL+          D+      P  +
Sbjct: 67  EVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKDQKEPKNK 126

Query: 117 PQLSCFRKSPLSNVVCEW----------------GPRSTPSLTTKAVLLVRKFQNSPAED 160
             L C  K+      C W                G      +T  A  L  +      ++
Sbjct: 127 TFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERVRGDNKE 186

Query: 161 FQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPA 220
           +    +YS E Q+ S   A P  + S  I  M  A       + T +F    I++PDPP 
Sbjct: 187 Y----EYSVECQEDS---ACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPK 239

Query: 221 NITVTAVARNPRWLSVTWQDPHSWNS--SFYRLRFELRYRAERSKTFTTWMVKDLQHHCV 278
           N+ +  + +N R + V+W+ P +W++  S++ L F ++ + +  +     +  D     V
Sbjct: 240 NLQLKPL-KNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATV 298

Query: 279 IHDAWSGLRHVVQLRAQEEFGQGEWSEWS 307
           I          + +RAQ+ +    WSEW+
Sbjct: 299 I----CRKNASISVRAQDRYYSSSWSEWA 323


>gi|28610149 interleukin 6 signal transducer isoform 2 precursor
           [Homo sapiens]
          Length = 329

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 55/225 (24%), Positives = 100/225 (44%), Gaps = 29/225 (12%)

Query: 106 VHLLVDVPPEEPQ-LSCFRKSPLSNVVCEW-GPRST---PSLTTKAVLLVRKFQNSPAED 160
           + ++  +PPE+P+ LSC        + CEW G R T    + T K+     KF +  A+ 
Sbjct: 118 ITIISGLPPEKPKNLSCIVNEG-KKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAK- 175

Query: 161 FQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCV----ASSVGSKFSKTQTFQGCGILQP 216
                         SC +      S+ Y V++ V     +++G   S    F     ++P
Sbjct: 176 ---------RDTPTSCTVDY----STVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKP 222

Query: 217 DPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDL--- 273
           +PP N++V         L +TW +P     S   L++ ++YR + + T++    +D    
Sbjct: 223 NPPHNLSVINSEELSSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQIPPEDTAST 280

Query: 274 QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTES 318
           +    + D      +V ++R  +E G+G WS+WS EA G  + ++
Sbjct: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDN 325


>gi|28610147 interleukin 6 signal transducer isoform 1 precursor
           [Homo sapiens]
          Length = 918

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 56/227 (24%), Positives = 100/227 (44%), Gaps = 29/227 (12%)

Query: 106 VHLLVDVPPEEPQ-LSCFRKSPLSNVVCEW-GPRST---PSLTTKAVLLVRKFQNSPAED 160
           + ++  +PPE+P+ LSC        + CEW G R T    + T K+     KF +  A+ 
Sbjct: 118 ITIISGLPPEKPKNLSCIVNEG-KKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAK- 175

Query: 161 FQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCV----ASSVGSKFSKTQTFQGCGILQP 216
                         SC +      S+ Y V++ V     +++G   S    F     ++P
Sbjct: 176 ---------RDTPTSCTVDY----STVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKP 222

Query: 217 DPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDL--- 273
           +PP N++V         L +TW +P     S   L++ ++YR + + T++    +D    
Sbjct: 223 NPPHNLSVINSEELSSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQIPPEDTAST 280

Query: 274 QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRS 320
           +    + D      +V ++R  +E G+G WS+WS EA G  + +  S
Sbjct: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPS 327


>gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]
          Length = 862

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 51/202 (25%), Positives = 83/202 (41%), Gaps = 12/202 (5%)

Query: 108 LLVDVPPEEPQ-LSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQ 166
           + V V PE+PQ LSC +K     V C W       L T+  L +   +N     +Q+ C+
Sbjct: 118 IFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLT---WQKQCK 174

Query: 167 YSQ-ESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVT 225
               +   F   L  PE   S +   +   +S+GS  S   TF    I++P PP +I + 
Sbjct: 175 DIYCDYLDFGINLT-PESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIK 233

Query: 226 AVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSG 285
               +    ++ W+D          L   LRYR   S+ +    V   +    + D    
Sbjct: 234 FQKASVSRCTLYWRD------EGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPF 287

Query: 286 LRHVVQLRAQEEFGQGEWSEWS 307
             +  Q+ ++    +G WS+WS
Sbjct: 288 TEYEFQISSKLHLYKGSWSDWS 309


>gi|4506107 prolactin receptor [Homo sapiens]
          Length = 622

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 47/202 (23%), Positives = 76/202 (37%), Gaps = 12/202 (5%)

Query: 112 VPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQES 171
           +PP +P++   R        C W P +   L T   L   +      E     C      
Sbjct: 26  LPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHR----EGETLMHECPDYITG 81

Query: 172 QKFSCQLAVPEGDS-SFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARN 230
              SC            YI+ +   + +GS FS         I+QPDPP  + V      
Sbjct: 82  GPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPE 141

Query: 231 PR--WLSVTWQDPH--SWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGL 286
            R  +L + W  P      + ++ L +E+R + E++  +        Q    I     G 
Sbjct: 142 DRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQ-QTEFKILSLHPGQ 200

Query: 287 RHVVQLRAQEEFGQGEWSEWSP 308
           +++VQ+R + +   G WS WSP
Sbjct: 201 KYLVQVRCKPD--HGYWSAWSP 220


>gi|14577917 Epstein-Barr virus induced 3 precursor [Homo sapiens]
          Length = 229

 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 49/207 (23%), Positives = 85/207 (41%), Gaps = 23/207 (11%)

Query: 117 PQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSC 176
           P++ C        V C W     P+ T+    +        A     PC   Q     SC
Sbjct: 31  PRVQCRASRYPIAVDCSWTLPPAPNSTSPVSFIATYRLGMAARGHSWPC-LQQTPTSTSC 89

Query: 177 QLA-VPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLS 235
            +  V     + Y++++      GS  S    F    I++PDPP  + ++ +A   R L 
Sbjct: 90  TITDVQLFSMAPYVLNVTAVHPWGSS-SSFVPFITEHIIKPDPPEGVRLSPLAE--RQLQ 146

Query: 236 VTWQDPHSWN-SSFYRLRFELRYRAERSKTF--------TTWMVKDLQHHCVIHDAWSGL 286
           V W+ P SW     + L++ +RY+ + +  F        T+++++ ++            
Sbjct: 147 VQWEPPGSWPFPEIFSLKYWIRYKRQGAARFHRVGPIEATSFILRAVRPRA--------- 197

Query: 287 RHVVQLRAQEEFGQGEWSEWSPEAMGT 313
           R+ VQ+ AQ+    GE S+WS  A  T
Sbjct: 198 RYYVQVAAQDLTDYGELSDWSLPATAT 224


>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
            precursor [Homo sapiens]
          Length = 2012

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 78/326 (23%), Positives = 123/326 (37%), Gaps = 47/326 (14%)

Query: 33   GVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRR-------LLLRS 85
            G +T+     + L C  V  + +  V W+  K + G+ PS     GRR        ++R+
Sbjct: 1293 GTVTTPWMKDIVLPCKAVG-DPSPAVKWM--KDSNGT-PSLVTIDGRRSIFSNGSFIIRT 1348

Query: 86   VQLHDSGNYSCY---RAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSL 142
            V+  DSG YSC      G     ++L V VPP++P+L+   K+  S++   W P      
Sbjct: 1349 VKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLT-VSKTTSSSITLSWLPGDNGGS 1407

Query: 143  TTKAVLLVRKFQNSPA-EDFQ-EPCQYSQESQKFSC------QLAVPEGDSSFYIVSMCV 194
            + +  +L     NS     F   P + S   +   C       L    G     I  +  
Sbjct: 1408 SIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIE 1467

Query: 195  ASSVGS--KFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLR 252
            A ++G   +FSK Q             A+I  T V  N     + W D     +S     
Sbjct: 1468 AKTLGKEPQFSKEQELF----------ASINTTRVRLN----LIGWNDGGCPITS----- 1508

Query: 253  FELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMG 312
            F L YR   +  +TT     L    +++D      + +Q+R     G    +E       
Sbjct: 1509 FTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAG---CAEKQANFAT 1565

Query: 313  TPWTESRSPPAENEVSTPMQALTTNK 338
              +  S  PP    V    + LTTN+
Sbjct: 1566 LNYDGSTIPPLIKSVVQNEEGLTTNE 1591



 Score = 29.3 bits (64), Expect = 5.8
 Identities = 32/174 (18%), Positives = 64/174 (36%), Gaps = 12/174 (6%)

Query: 90   DSGNYSCYRA---GRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKA 146
            DSG +SC+     G   G + L V  PP+ P++   +      +   W    T      +
Sbjct: 859  DSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIE-IKDVKARTITLRW----TMGFDGNS 913

Query: 147  VLLVRKFQNSPAEDFQEPCQYSQE-SQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKT 205
             +     +     D  +  Q +++ S + +    +    SS Y + M   + +G      
Sbjct: 914  PITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN 973

Query: 206  QTFQGCGILQPD-PPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYR 258
            +         PD PP  + +  ++     + VTW+ P     +     +++ YR
Sbjct: 974  ELTITADEAAPDGPPQEVHLEPISSQS--IRVTWKAPKKHLQNGIIRGYQIGYR 1025



 Score = 28.9 bits (63), Expect = 7.6
 Identities = 35/137 (25%), Positives = 54/137 (39%), Gaps = 23/137 (16%)

Query: 81  LLLRSVQLHDSGNYSCYRAGRPAGTVH---LLVDVPPE-----EPQLSCFRKSPLSNVVC 132
           L + ++ L  +GNY+C      A   H   L+V VPP+       Q   + K+ + N   
Sbjct: 654 LRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSA 713

Query: 133 EWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFS----CQLAVPEGDSSFY 188
           E  P  T         +V KF         +P   +   Q  S        V E DS +Y
Sbjct: 714 EGYPVPT---------IVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYY 764

Query: 189 IVSMCVASSVGSKFSKT 205
           +    V++ VG+  SK+
Sbjct: 765 LCK--VSNDVGADVSKS 779


>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
            sapiens]
          Length = 2113

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 36/125 (28%), Positives = 57/125 (45%), Gaps = 14/125 (11%)

Query: 81   LLLRSVQLHDSGNYSCYRA---GRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPR 137
            LLLR+V+  DSG Y+C      G     V+LLV VPP++P+L+   K+  S++   W P 
Sbjct: 1408 LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLT-VSKTSASSITLTWIPG 1466

Query: 138  STPSLTTKAVLLVRKFQNSP--AEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVA 195
                 + +  +L     NS    + F    + S +     C         ++Y V +   
Sbjct: 1467 DNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKC--------GTWYKVKLAAK 1518

Query: 196  SSVGS 200
            +SVGS
Sbjct: 1519 NSVGS 1523



 Score = 30.4 bits (67), Expect = 2.6
 Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 10/165 (6%)

Query: 81   LLLRSVQLHDSGNYSCYRA---GRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPR 137
            L L+     DS  +SC+     G   G + L V  PP+ P+L   R+    ++   W  R
Sbjct: 912  LKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELE-IREVKARSMNLRWTQR 970

Query: 138  STPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASS 197
               +       +  K   S + DF++  +    S   +    V    +S Y + M   + 
Sbjct: 971  FDGNSIITGFDIEYK-NKSDSWDFKQSTR--NISPTINQANIVDLHPASVYSIRMYSFNK 1027

Query: 198  VG-SKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDP 241
            +G S+ SK  T          PP ++T+  V      + VTW+ P
Sbjct: 1028 IGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQS--IQVTWKAP 1070


>gi|51093381 leptin receptor isoform 3 [Homo sapiens]
          Length = 958

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 44/200 (22%), Positives = 83/200 (41%), Gaps = 12/200 (6%)

Query: 119 LSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNS-------PAEDFQEPCQYSQES 171
           +SC     L+ + C W   +  SL  ++ L +R  ++S             EP     +S
Sbjct: 434 ISCETDGYLTKMTCRWSTSTIQSLA-ESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQS 492

Query: 172 QKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNP 231
             F   +  P    S Y + + +  S+GS  S         +++P PP+++    +  N 
Sbjct: 493 DGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAE-ITINI 551

Query: 232 RWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVV 290
             L ++W+ P    N+  +++R+ L  +  + K +  +  K       + D  +   + V
Sbjct: 552 GLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAV--YAV 609

Query: 291 QLRAQEEFGQGEWSEWSPEA 310
           Q+R +   G G WS WS  A
Sbjct: 610 QVRCKRLDGLGYWSNWSNPA 629



 Score = 35.4 bits (80), Expect = 0.081
 Identities = 34/153 (22%), Positives = 63/153 (41%), Gaps = 16/153 (10%)

Query: 176 CQLAVPEGDSSFYIVSMCVASSVGSKF-SKTQTFQGCGILQPDPPANITVTAVARNPRWL 234
           C + VP    +  ++     +S G  F S   + Q   +++PDPP  + +         L
Sbjct: 196 CLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--L 253

Query: 235 SVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH-----HCVIHDAWSGLRHV 289
            ++W  P         + F L+Y+ + S+  TT ++++          ++     G  + 
Sbjct: 254 KISWSSPPL-------VPFPLQYQVKYSENSTT-VIREADKIVSATSLLVDSILPGSSYE 305

Query: 290 VQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPP 322
           VQ+R +   G G WS+WS   + T       PP
Sbjct: 306 VQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPP 338


>gi|51093379 leptin receptor isoform 2 [Homo sapiens]
          Length = 896

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 44/200 (22%), Positives = 83/200 (41%), Gaps = 12/200 (6%)

Query: 119 LSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNS-------PAEDFQEPCQYSQES 171
           +SC     L+ + C W   +  SL  ++ L +R  ++S             EP     +S
Sbjct: 434 ISCETDGYLTKMTCRWSTSTIQSLA-ESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQS 492

Query: 172 QKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNP 231
             F   +  P    S Y + + +  S+GS  S         +++P PP+++    +  N 
Sbjct: 493 DGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAE-ITINI 551

Query: 232 RWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVV 290
             L ++W+ P    N+  +++R+ L  +  + K +  +  K       + D  +   + V
Sbjct: 552 GLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAV--YAV 609

Query: 291 QLRAQEEFGQGEWSEWSPEA 310
           Q+R +   G G WS WS  A
Sbjct: 610 QVRCKRLDGLGYWSNWSNPA 629



 Score = 35.4 bits (80), Expect = 0.081
 Identities = 34/153 (22%), Positives = 63/153 (41%), Gaps = 16/153 (10%)

Query: 176 CQLAVPEGDSSFYIVSMCVASSVGSKF-SKTQTFQGCGILQPDPPANITVTAVARNPRWL 234
           C + VP    +  ++     +S G  F S   + Q   +++PDPP  + +         L
Sbjct: 196 CLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--L 253

Query: 235 SVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH-----HCVIHDAWSGLRHV 289
            ++W  P         + F L+Y+ + S+  TT ++++          ++     G  + 
Sbjct: 254 KISWSSPPL-------VPFPLQYQVKYSENSTT-VIREADKIVSATSLLVDSILPGSSYE 305

Query: 290 VQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPP 322
           VQ+R +   G G WS+WS   + T       PP
Sbjct: 306 VQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPP 338


>gi|40254464 leptin receptor isoform 1 [Homo sapiens]
          Length = 1165

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 44/200 (22%), Positives = 83/200 (41%), Gaps = 12/200 (6%)

Query: 119 LSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNS-------PAEDFQEPCQYSQES 171
           +SC     L+ + C W   +  SL  ++ L +R  ++S             EP     +S
Sbjct: 434 ISCETDGYLTKMTCRWSTSTIQSLA-ESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQS 492

Query: 172 QKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNP 231
             F   +  P    S Y + + +  S+GS  S         +++P PP+++    +  N 
Sbjct: 493 DGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAE-ITINI 551

Query: 232 RWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVV 290
             L ++W+ P    N+  +++R+ L  +  + K +  +  K       + D  +   + V
Sbjct: 552 GLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAV--YAV 609

Query: 291 QLRAQEEFGQGEWSEWSPEA 310
           Q+R +   G G WS WS  A
Sbjct: 610 QVRCKRLDGLGYWSNWSNPA 629



 Score = 35.4 bits (80), Expect = 0.081
 Identities = 34/153 (22%), Positives = 63/153 (41%), Gaps = 16/153 (10%)

Query: 176 CQLAVPEGDSSFYIVSMCVASSVGSKF-SKTQTFQGCGILQPDPPANITVTAVARNPRWL 234
           C + VP    +  ++     +S G  F S   + Q   +++PDPP  + +         L
Sbjct: 196 CLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--L 253

Query: 235 SVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH-----HCVIHDAWSGLRHV 289
            ++W  P         + F L+Y+ + S+  TT ++++          ++     G  + 
Sbjct: 254 KISWSSPPL-------VPFPLQYQVKYSENSTT-VIREADKIVSATSLLVDSILPGSSYE 305

Query: 290 VQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPP 322
           VQ+R +   G G WS+WS   + T       PP
Sbjct: 306 VQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPP 338


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 32/87 (36%), Positives = 40/87 (45%), Gaps = 7/87 (8%)

Query: 33   GVLTSLPGDSVTLTCPGVEPEDNATVHWVL-RKPAAGSHPSRWAGMGRRLLLRSVQLHDS 91
            G L S PG+ VT+ CP V       V W+    P   S  +   G G  L +  VQL D+
Sbjct: 2130 GTLVSRPGELVTMVCP-VRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADA 2188

Query: 92   GNYSCYRAGRPAGTVH----LLVDVPP 114
            G ++C  A  PAG       L V VPP
Sbjct: 2189 GIFTCV-AASPAGVADRNFTLQVQVPP 2214



 Score = 34.7 bits (78), Expect = 0.14
 Identities = 34/89 (38%), Positives = 40/89 (44%), Gaps = 21/89 (23%)

Query: 38  LPGDSVTLTC--PGVEPEDNATVHWVLRKPAAGSHP-SRWAGM-----GRRLLLRSVQLH 89
           L   SVTL C   GV P D   V W       G  P S W G+     GR L +   QL 
Sbjct: 707 LENASVTLECLASGVPPPD---VSWF-----KGHQPVSSWMGVTVSVDGRVLRIEQAQLS 758

Query: 90  DSGNYSCYRAGRPAGTVH----LLVDVPP 114
           D+G+Y C  A   AG+      L V+VPP
Sbjct: 759 DAGSYRCV-ASNVAGSTELRYGLRVNVPP 786



 Score = 32.7 bits (73), Expect = 0.53
 Identities = 28/95 (29%), Positives = 41/95 (43%), Gaps = 9/95 (9%)

Query: 26   PAQEVARGVLTSLPGDSVTLTCPG--VEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLL 82
            P  EV    + +    ++TL C    V P    T+ W    +P   S   +  G GR L 
Sbjct: 1449 PLGEVGVKEVKTKVNSTLTLECESWAVPPP---TIRWYKDGQPVTPSSRLQVLGEGRLLQ 1505

Query: 83   LRSVQLHDSGNYSCYR---AGRPAGTVHLLVDVPP 114
            ++  Q+ DSG Y C     AG      ++L+ VPP
Sbjct: 1506 IQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 1540



 Score = 32.3 bits (72), Expect = 0.69
 Identities = 34/113 (30%), Positives = 50/113 (44%), Gaps = 11/113 (9%)

Query: 40   GDSVTLTCPGVEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSC-- 96
            GD   L+C   +     TV W    +P   +  ++    G+RL ++  Q+ D G YSC  
Sbjct: 1856 GDKAVLSCE-TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKV 1914

Query: 97   -YRAGRPAGTVHLLVDVPP--EEPQ---LSCFRKSPLSNVVCEWGPRSTPSLT 143
               AG    T  L V VPP  E P+   +S    SPL  + C+      P++T
Sbjct: 1915 SNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLV-LTCDVSGVPAPTVT 1966



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 26/79 (32%), Positives = 33/79 (41%), Gaps = 7/79 (8%)

Query: 21   APRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW---VLRKPAAGSHPSRWAGM 77
            AP         R V+   PG  V       EP    T H    VL++ A    P R    
Sbjct: 2387 APPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPER---- 2442

Query: 78   GRRLLLRSVQLHDSGNYSC 96
            GR L L+++   DSG+YSC
Sbjct: 2443 GRFLQLQALSTADSGDYSC 2461


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 32/87 (36%), Positives = 40/87 (45%), Gaps = 7/87 (8%)

Query: 33   GVLTSLPGDSVTLTCPGVEPEDNATVHWVL-RKPAAGSHPSRWAGMGRRLLLRSVQLHDS 91
            G L S PG+ VT+ CP V       V W+    P   S  +   G G  L +  VQL D+
Sbjct: 3321 GTLVSRPGELVTMVCP-VRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADA 3379

Query: 92   GNYSCYRAGRPAGTVH----LLVDVPP 114
            G ++C  A  PAG       L V VPP
Sbjct: 3380 GIFTCV-AASPAGVADRNFTLQVQVPP 3405



 Score = 34.7 bits (78), Expect = 0.14
 Identities = 34/89 (38%), Positives = 40/89 (44%), Gaps = 21/89 (23%)

Query: 38   LPGDSVTLTC--PGVEPEDNATVHWVLRKPAAGSHP-SRWAGM-----GRRLLLRSVQLH 89
            L   SVTL C   GV P D   V W       G  P S W G+     GR L +   QL 
Sbjct: 1898 LENASVTLECLASGVPPPD---VSWF-----KGHQPVSSWMGVTVSVDGRVLRIEQAQLS 1949

Query: 90   DSGNYSCYRAGRPAGTVH----LLVDVPP 114
            D+G+Y C  A   AG+      L V+VPP
Sbjct: 1950 DAGSYRCV-ASNVAGSTELRYGLRVNVPP 1977



 Score = 32.7 bits (73), Expect = 0.53
 Identities = 28/95 (29%), Positives = 41/95 (43%), Gaps = 9/95 (9%)

Query: 26   PAQEVARGVLTSLPGDSVTLTCPG--VEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLL 82
            P  EV    + +    ++TL C    V P    T+ W    +P   S   +  G GR L 
Sbjct: 2640 PLGEVGVKEVKTKVNSTLTLECESWAVPPP---TIRWYKDGQPVTPSSRLQVLGEGRLLQ 2696

Query: 83   LRSVQLHDSGNYSCYR---AGRPAGTVHLLVDVPP 114
            ++  Q+ DSG Y C     AG      ++L+ VPP
Sbjct: 2697 IQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 2731



 Score = 32.3 bits (72), Expect = 0.69
 Identities = 34/113 (30%), Positives = 50/113 (44%), Gaps = 11/113 (9%)

Query: 40   GDSVTLTCPGVEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSC-- 96
            GD   L+C   +     TV W    +P   +  ++    G+RL ++  Q+ D G YSC  
Sbjct: 3047 GDKAVLSCE-TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKV 3105

Query: 97   -YRAGRPAGTVHLLVDVPP--EEPQ---LSCFRKSPLSNVVCEWGPRSTPSLT 143
               AG    T  L V VPP  E P+   +S    SPL  + C+      P++T
Sbjct: 3106 SNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLV-LTCDVSGVPAPTVT 3157



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 26/79 (32%), Positives = 33/79 (41%), Gaps = 7/79 (8%)

Query: 21   APRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW---VLRKPAAGSHPSRWAGM 77
            AP         R V+   PG  V       EP    T H    VL++ A    P R    
Sbjct: 3578 APPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPER---- 3633

Query: 78   GRRLLLRSVQLHDSGNYSC 96
            GR L L+++   DSG+YSC
Sbjct: 3634 GRFLQLQALSTADSGDYSC 3652



 Score = 28.9 bits (63), Expect = 7.6
 Identities = 18/39 (46%), Positives = 22/39 (56%), Gaps = 5/39 (12%)

Query: 81   LLLRSVQLHDSGNYSCYRAGRPAGTVH----LLVDVPPE 115
            L L  VQ+ DSG+Y C  A  PAG+      L V VPP+
Sbjct: 1084 LRLAQVQVGDSGHYEC-TASNPAGSASHRYVLGVQVPPQ 1121


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 32/87 (36%), Positives = 40/87 (45%), Gaps = 7/87 (8%)

Query: 33   GVLTSLPGDSVTLTCPGVEPEDNATVHWVL-RKPAAGSHPSRWAGMGRRLLLRSVQLHDS 91
            G L S PG+ VT+ CP V       V W+    P   S  +   G G  L +  VQL D+
Sbjct: 2039 GTLVSRPGELVTMVCP-VRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADA 2097

Query: 92   GNYSCYRAGRPAGTVH----LLVDVPP 114
            G ++C  A  PAG       L V VPP
Sbjct: 2098 GIFTCV-AASPAGVADRNFTLQVQVPP 2123



 Score = 34.7 bits (78), Expect = 0.14
 Identities = 34/89 (38%), Positives = 40/89 (44%), Gaps = 21/89 (23%)

Query: 38  LPGDSVTLTC--PGVEPEDNATVHWVLRKPAAGSHP-SRWAGM-----GRRLLLRSVQLH 89
           L   SVTL C   GV P D   V W       G  P S W G+     GR L +   QL 
Sbjct: 616 LENASVTLECLASGVPPPD---VSWF-----KGHQPVSSWMGVTVSVDGRVLRIEQAQLS 667

Query: 90  DSGNYSCYRAGRPAGTVH----LLVDVPP 114
           D+G+Y C  A   AG+      L V+VPP
Sbjct: 668 DAGSYRCV-ASNVAGSTELRYGLRVNVPP 695



 Score = 33.1 bits (74), Expect = 0.40
 Identities = 28/95 (29%), Positives = 41/95 (43%), Gaps = 9/95 (9%)

Query: 26   PAQEVARGVLTSLPGDSVTLTCPG--VEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLL 82
            P  EV    + +    ++TL C    V P    T+ W    +P   S   +  G GR L 
Sbjct: 1358 PLAEVGVKEVKTKVNSTLTLECESWAVPPP---TIRWYKDGQPVTPSSRLQVLGEGRLLQ 1414

Query: 83   LRSVQLHDSGNYSCYR---AGRPAGTVHLLVDVPP 114
            ++  Q+ DSG Y C     AG      ++L+ VPP
Sbjct: 1415 IQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 1449



 Score = 32.3 bits (72), Expect = 0.69
 Identities = 34/113 (30%), Positives = 50/113 (44%), Gaps = 11/113 (9%)

Query: 40   GDSVTLTCPGVEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSC-- 96
            GD   L+C   +     TV W    +P   +  ++    G+RL ++  Q+ D G YSC  
Sbjct: 1765 GDKAVLSCE-TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKV 1823

Query: 97   -YRAGRPAGTVHLLVDVPP--EEPQ---LSCFRKSPLSNVVCEWGPRSTPSLT 143
               AG    T  L V VPP  E P+   +S    SPL  + C+      P++T
Sbjct: 1824 SNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLV-LTCDVSGVPAPTVT 1875



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 26/79 (32%), Positives = 33/79 (41%), Gaps = 7/79 (8%)

Query: 21   APRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW---VLRKPAAGSHPSRWAGM 77
            AP         R V+   PG  V       EP    T H    VL++ A    P R    
Sbjct: 2296 APPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPER---- 2351

Query: 78   GRRLLLRSVQLHDSGNYSC 96
            GR L L+++   DSG+YSC
Sbjct: 2352 GRFLQLQALSTADSGDYSC 2370


>gi|115430248 gp130-like monocyte receptor [Homo sapiens]
          Length = 764

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 59/254 (23%), Positives = 94/254 (37%), Gaps = 49/254 (19%)

Query: 109 LVDVPPEEPQLSC---FRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKF--------QNSP 157
           L  +P +   +SC   +RK    N+ C W P    S T   V     F         NS 
Sbjct: 50  LAALPAKPENISCVYYYRK----NLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSS 105

Query: 158 AEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPD 217
             + +  C +      F  ++ +P+     Y + +   +  G   S    ++   I + +
Sbjct: 106 TSENRASCSF------FLPRITIPDN----YTIEVEAENGDGVIKSHMTYWRLENIAKTE 155

Query: 218 PPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMV------- 270
           PP    V  V    R + + W  P     S   L++ LR+R   S   T+WM        
Sbjct: 156 PPKIFRVKPVLGIKRMIQIEWIKPELAPVSS-DLKYTLRFRTVNS---TSWMEVNFAKNR 211

Query: 271 KDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSP--------- 321
           KD      +        +V+ LR   +  +  WS+WS E MG   TE  +P         
Sbjct: 212 KDKNQTYNLTGLQPFTEYVIALRCAVKESKF-WSDWSQEKMG--MTEEEAPCGLELWRVL 268

Query: 322 -PAENEVSTPMQAL 334
            PAE +   P++ L
Sbjct: 269 KPAEADGRRPVRLL 282


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 39.7 bits (91), Expect = 0.004
 Identities = 35/120 (29%), Positives = 51/120 (42%), Gaps = 6/120 (5%)

Query: 216   PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAE-RSKTFTTWMVKDL 273
             P PP N+T+T V  N   +S+TW+ P +   +       ELR +   R  T  T   +DL
Sbjct: 13191 PGPPLNVTITDV--NRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDL 13248

Query: 274   QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQA 333
                  + D   G  +  ++RAQ   G G+ S  +P        E  SPP     S   Q+
Sbjct: 13249 S--ATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQS 13306



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 25/118 (21%), Positives = 50/118 (42%), Gaps = 8/118 (6%)

Query: 184   DSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHS 243
             DS  Y +++  +S   S F   +         P PP N+ VT + ++   +S+TW+ P  
Sbjct: 23007 DSGKYTLTLENSSGTKSAFVTVRVLD-----TPSPPVNLKVTEITKDS--VSITWEPPLL 23059

Query: 244   WNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQG 301
                S  +  + +  R    K++   +    ++   I     G  +  ++ A+ E+G G
Sbjct: 23060 DGGSKIK-NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIG 23116



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 41/189 (21%), Positives = 74/189 (39%), Gaps = 16/189 (8%)

Query: 160   DFQEPCQYSQESQKF----SCQLAVPEG---DSSFYIVSMCVASSVGSKFSKTQTFQGCG 212
             D +EP  Y     K     +C L +P+    D+  Y ++    +++G+  SK       G
Sbjct: 16159 DNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTIT--AVNNLGTA-SKEMRLNVLG 16215

Query: 213   ILQPDPPAN-ITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVK 271
               +P PP   I   +V+ +   LS  W  P     S     + +  R    KT+     +
Sbjct: 16216 --RPGPPVGPIKFESVSADQMTLS--WFPPKDDGGSKIT-NYVIEKREANRKTWVHVSSE 16270

Query: 272   DLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPM 331
               +    I     G  +V ++ AQ ++G GE  +  PE     ++   +P      S   
Sbjct: 16271 PKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTR 16330

Query: 332   QALTTNKDD 340
              ++T N ++
Sbjct: 16331 NSMTVNWEE 16339



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 13/101 (12%)

Query: 216   PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTW-MVKDL 273
             P PP  ITV  V RN   +S++W  P H   S    +++ +  +A+ S+ ++    VK L
Sbjct: 23131 PQPPGKITVDDVTRNS--VSLSWTKPEHDGGSKI--IQYIVEMQAKHSEKWSECARVKSL 23186

Query: 274   QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTP 314
             Q   VI +   G  ++ ++ A  E G+ +     P ++  P
Sbjct: 23187 Q--AVITNLTQGEEYLFRVVAVNEKGRSD-----PRSLAVP 23220



 Score = 29.3 bits (64), Expect = 5.8
 Identities = 20/90 (22%), Positives = 44/90 (48%), Gaps = 3/90 (3%)

Query: 216   PDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH 275
             P PP N+TV  ++++  +  VTW+ P     S   + + ++ R    K+++T   +  + 
Sbjct: 19787 PGPPVNVTVKEISKDSAY--VTWEPPIIDGGSPI-INYVVQKRDAERKSWSTVTTECSKT 19843

Query: 276   HCVIHDAWSGLRHVVQLRAQEEFGQGEWSE 305
                + +   G  +  ++ A+ E+G G+  E
Sbjct: 19844 SFRVANLEEGKSYFFRVFAENEYGIGDPGE 19873



 Score = 28.9 bits (63), Expect = 7.6
 Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 7/64 (10%)

Query: 180   VPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQ 239
             V   D+ FY+V  C  +  G    KT       +  PDPP  + V+ V+R+   +++TW 
Sbjct: 31091 VERKDAGFYVV--CAKNRFGID-QKTVELDVADV--PDPPRGVKVSDVSRDS--VNLTWT 31143

Query: 240   DPHS 243
             +P S
Sbjct: 31144 EPAS 31147


>gi|110349717 titin isoform novex-2 [Homo sapiens]
          Length = 27118

 Score = 39.7 bits (91), Expect = 0.004
 Identities = 35/120 (29%), Positives = 51/120 (42%), Gaps = 6/120 (5%)

Query: 216  PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAE-RSKTFTTWMVKDL 273
            P PP N+T+T V  N   +S+TW+ P +   +       ELR +   R  T  T   +DL
Sbjct: 6886 PGPPLNVTITDV--NRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDL 6943

Query: 274  QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQA 333
                 + D   G  +  ++RAQ   G G+ S  +P        E  SPP     S   Q+
Sbjct: 6944 S--ATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQS 7001



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 25/118 (21%), Positives = 50/118 (42%), Gaps = 8/118 (6%)

Query: 184   DSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHS 243
             DS  Y +++  +S   S F   +         P PP N+ VT + ++   +S+TW+ P  
Sbjct: 16702 DSGKYTLTLENSSGTKSAFVTVRVLD-----TPSPPVNLKVTEITKDS--VSITWEPPLL 16754

Query: 244   WNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQG 301
                S  +  + +  R    K++   +    ++   I     G  +  ++ A+ E+G G
Sbjct: 16755 DGGSKIK-NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIG 16811



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 41/189 (21%), Positives = 74/189 (39%), Gaps = 16/189 (8%)

Query: 160   DFQEPCQYSQESQKF----SCQLAVPEG---DSSFYIVSMCVASSVGSKFSKTQTFQGCG 212
             D +EP  Y     K     +C L +P+    D+  Y ++    +++G+  SK       G
Sbjct: 9854  DNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTIT--AVNNLGTA-SKEMRLNVLG 9910

Query: 213   ILQPDPPAN-ITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVK 271
               +P PP   I   +V+ +   LS  W  P     S     + +  R    KT+     +
Sbjct: 9911  --RPGPPVGPIKFESVSADQMTLS--WFPPKDDGGSKIT-NYVIEKREANRKTWVHVSSE 9965

Query: 272   DLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPM 331
               +    I     G  +V ++ AQ ++G GE  +  PE     ++   +P      S   
Sbjct: 9966  PKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTR 10025

Query: 332   QALTTNKDD 340
              ++T N ++
Sbjct: 10026 NSMTVNWEE 10034



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 13/101 (12%)

Query: 216   PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTW-MVKDL 273
             P PP  ITV  V RN   +S++W  P H   S    +++ +  +A+ S+ ++    VK L
Sbjct: 16826 PQPPGKITVDDVTRNS--VSLSWTKPEHDGGSKI--IQYIVEMQAKHSEKWSECARVKSL 16881

Query: 274   QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTP 314
             Q   VI +   G  ++ ++ A  E G+ +     P ++  P
Sbjct: 16882 Q--AVITNLTQGEEYLFRVVAVNEKGRSD-----PRSLAVP 16915



 Score = 29.3 bits (64), Expect = 5.8
 Identities = 20/90 (22%), Positives = 44/90 (48%), Gaps = 3/90 (3%)

Query: 216   PDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH 275
             P PP N+TV  ++++  +  VTW+ P     S   + + ++ R    K+++T   +  + 
Sbjct: 13482 PGPPVNVTVKEISKDSAY--VTWEPPIIDGGSPI-INYVVQKRDAERKSWSTVTTECSKT 13538

Query: 276   HCVIHDAWSGLRHVVQLRAQEEFGQGEWSE 305
                + +   G  +  ++ A+ E+G G+  E
Sbjct: 13539 SFRVANLEEGKSYFFRVFAENEYGIGDPGE 13568



 Score = 28.9 bits (63), Expect = 7.6
 Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 7/64 (10%)

Query: 180   VPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQ 239
             V   D+ FY+V  C  +  G    KT       +  PDPP  + V+ V+R+   +++TW 
Sbjct: 24786 VERKDAGFYVV--CAKNRFGID-QKTVELDVADV--PDPPRGVKVSDVSRDS--VNLTWT 24838

Query: 240   DPHS 243
             +P S
Sbjct: 24839 EPAS 24842


>gi|110349713 titin isoform novex-1 [Homo sapiens]
          Length = 27051

 Score = 39.7 bits (91), Expect = 0.004
 Identities = 35/120 (29%), Positives = 51/120 (42%), Gaps = 6/120 (5%)

Query: 216  PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAE-RSKTFTTWMVKDL 273
            P PP N+T+T V  N   +S+TW+ P +   +       ELR +   R  T  T   +DL
Sbjct: 6819 PGPPLNVTITDV--NRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDL 6876

Query: 274  QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQA 333
                 + D   G  +  ++RAQ   G G+ S  +P        E  SPP     S   Q+
Sbjct: 6877 S--ATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQS 6934



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 25/118 (21%), Positives = 50/118 (42%), Gaps = 8/118 (6%)

Query: 184   DSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHS 243
             DS  Y +++  +S   S F   +         P PP N+ VT + ++   +S+TW+ P  
Sbjct: 16635 DSGKYTLTLENSSGTKSAFVTVRVLD-----TPSPPVNLKVTEITKDS--VSITWEPPLL 16687

Query: 244   WNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQG 301
                S  +  + +  R    K++   +    ++   I     G  +  ++ A+ E+G G
Sbjct: 16688 DGGSKIK-NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIG 16744



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 41/189 (21%), Positives = 74/189 (39%), Gaps = 16/189 (8%)

Query: 160  DFQEPCQYSQESQKF----SCQLAVPEG---DSSFYIVSMCVASSVGSKFSKTQTFQGCG 212
            D +EP  Y     K     +C L +P+    D+  Y ++    +++G+  SK       G
Sbjct: 9787 DNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTIT--AVNNLGTA-SKEMRLNVLG 9843

Query: 213  ILQPDPPAN-ITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVK 271
              +P PP   I   +V+ +   LS  W  P     S     + +  R    KT+     +
Sbjct: 9844 --RPGPPVGPIKFESVSADQMTLS--WFPPKDDGGSKIT-NYVIEKREANRKTWVHVSSE 9898

Query: 272  DLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPM 331
              +    I     G  +V ++ AQ ++G GE  +  PE     ++   +P      S   
Sbjct: 9899 PKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTR 9958

Query: 332  QALTTNKDD 340
             ++T N ++
Sbjct: 9959 NSMTVNWEE 9967



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 13/101 (12%)

Query: 216   PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTW-MVKDL 273
             P PP  ITV  V RN   +S++W  P H   S    +++ +  +A+ S+ ++    VK L
Sbjct: 16759 PQPPGKITVDDVTRNS--VSLSWTKPEHDGGSKI--IQYIVEMQAKHSEKWSECARVKSL 16814

Query: 274   QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTP 314
             Q   VI +   G  ++ ++ A  E G+ +     P ++  P
Sbjct: 16815 Q--AVITNLTQGEEYLFRVVAVNEKGRSD-----PRSLAVP 16848



 Score = 29.3 bits (64), Expect = 5.8
 Identities = 20/90 (22%), Positives = 44/90 (48%), Gaps = 3/90 (3%)

Query: 216   PDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH 275
             P PP N+TV  ++++  +  VTW+ P     S   + + ++ R    K+++T   +  + 
Sbjct: 13415 PGPPVNVTVKEISKDSAY--VTWEPPIIDGGSPI-INYVVQKRDAERKSWSTVTTECSKT 13471

Query: 276   HCVIHDAWSGLRHVVQLRAQEEFGQGEWSE 305
                + +   G  +  ++ A+ E+G G+  E
Sbjct: 13472 SFRVANLEEGKSYFFRVFAENEYGIGDPGE 13501



 Score = 28.9 bits (63), Expect = 7.6
 Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 7/64 (10%)

Query: 180   VPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQ 239
             V   D+ FY+V  C  +  G    KT       +  PDPP  + V+ V+R+   +++TW 
Sbjct: 24719 VERKDAGFYVV--CAKNRFGID-QKTVELDVADV--PDPPRGVKVSDVSRDS--VNLTWT 24771

Query: 240   DPHS 243
             +P S
Sbjct: 24772 EPAS 24775


>gi|110349715 titin isoform N2-B [Homo sapiens]
          Length = 26926

 Score = 39.7 bits (91), Expect = 0.004
 Identities = 35/120 (29%), Positives = 51/120 (42%), Gaps = 6/120 (5%)

Query: 216  PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAE-RSKTFTTWMVKDL 273
            P PP N+T+T V  N   +S+TW+ P +   +       ELR +   R  T  T   +DL
Sbjct: 6694 PGPPLNVTITDV--NRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDL 6751

Query: 274  QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQA 333
                 + D   G  +  ++RAQ   G G+ S  +P        E  SPP     S   Q+
Sbjct: 6752 S--ATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQS 6809



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 25/118 (21%), Positives = 50/118 (42%), Gaps = 8/118 (6%)

Query: 184   DSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHS 243
             DS  Y +++  +S   S F   +         P PP N+ VT + ++   +S+TW+ P  
Sbjct: 16510 DSGKYTLTLENSSGTKSAFVTVRVLD-----TPSPPVNLKVTEITKDS--VSITWEPPLL 16562

Query: 244   WNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQG 301
                S  +  + +  R    K++   +    ++   I     G  +  ++ A+ E+G G
Sbjct: 16563 DGGSKIK-NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIG 16619



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 41/189 (21%), Positives = 74/189 (39%), Gaps = 16/189 (8%)

Query: 160  DFQEPCQYSQESQKF----SCQLAVPEG---DSSFYIVSMCVASSVGSKFSKTQTFQGCG 212
            D +EP  Y     K     +C L +P+    D+  Y ++    +++G+  SK       G
Sbjct: 9662 DNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTIT--AVNNLGTA-SKEMRLNVLG 9718

Query: 213  ILQPDPPAN-ITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVK 271
              +P PP   I   +V+ +   LS  W  P     S     + +  R    KT+     +
Sbjct: 9719 --RPGPPVGPIKFESVSADQMTLS--WFPPKDDGGSKIT-NYVIEKREANRKTWVHVSSE 9773

Query: 272  DLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPM 331
              +    I     G  +V ++ AQ ++G GE  +  PE     ++   +P      S   
Sbjct: 9774 PKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTR 9833

Query: 332  QALTTNKDD 340
             ++T N ++
Sbjct: 9834 NSMTVNWEE 9842



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 13/101 (12%)

Query: 216   PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTW-MVKDL 273
             P PP  ITV  V RN   +S++W  P H   S    +++ +  +A+ S+ ++    VK L
Sbjct: 16634 PQPPGKITVDDVTRNS--VSLSWTKPEHDGGSKI--IQYIVEMQAKHSEKWSECARVKSL 16689

Query: 274   QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTP 314
             Q   VI +   G  ++ ++ A  E G+ +     P ++  P
Sbjct: 16690 Q--AVITNLTQGEEYLFRVVAVNEKGRSD-----PRSLAVP 16723



 Score = 29.3 bits (64), Expect = 5.8
 Identities = 20/90 (22%), Positives = 44/90 (48%), Gaps = 3/90 (3%)

Query: 216   PDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH 275
             P PP N+TV  ++++  +  VTW+ P     S   + + ++ R    K+++T   +  + 
Sbjct: 13290 PGPPVNVTVKEISKDSAY--VTWEPPIIDGGSPI-INYVVQKRDAERKSWSTVTTECSKT 13346

Query: 276   HCVIHDAWSGLRHVVQLRAQEEFGQGEWSE 305
                + +   G  +  ++ A+ E+G G+  E
Sbjct: 13347 SFRVANLEEGKSYFFRVFAENEYGIGDPGE 13376



 Score = 28.9 bits (63), Expect = 7.6
 Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 7/64 (10%)

Query: 180   VPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQ 239
             V   D+ FY+V  C  +  G    KT       +  PDPP  + V+ V+R+   +++TW 
Sbjct: 24594 VERKDAGFYVV--CAKNRFGID-QKTVELDVADV--PDPPRGVKVSDVSRDS--VNLTWT 24646

Query: 240   DPHS 243
             +P S
Sbjct: 24647 EPAS 24650


>gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Homo
           sapiens]
          Length = 602

 Score = 38.5 bits (88), Expect = 0.010
 Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 12/124 (9%)

Query: 40  GDSVTLTCPGVEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSC-- 96
           G  + L C   + +  AT+ WVL+ +  + SHP  W      L LR V+  DSG Y+C  
Sbjct: 280 GQFLRLLC-AADSQPPATLSWVLQDRVLSSSHP--WGPRTLGLELRGVRAGDSGRYTCRA 336

Query: 97  -YRAGRPAGTVHLLVDVPPE--EPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKF 153
             R G     + L V  PPE     +S   ++ L N+       S P L  +++ LV   
Sbjct: 337 ENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENL---GNGTSLPVLEGQSLRLVCVT 393

Query: 154 QNSP 157
            +SP
Sbjct: 394 HSSP 397


>gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Homo
           sapiens]
          Length = 698

 Score = 38.5 bits (88), Expect = 0.010
 Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 12/124 (9%)

Query: 40  GDSVTLTCPGVEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSC-- 96
           G  + L C   + +  AT+ WVL+ +  + SHP  W      L LR V+  DSG Y+C  
Sbjct: 280 GQFLRLLC-AADSQPPATLSWVLQDRVLSSSHP--WGPRTLGLELRGVRAGDSGRYTCRA 336

Query: 97  -YRAGRPAGTVHLLVDVPPE--EPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKF 153
             R G     + L V  PPE     +S   ++ L N+       S P L  +++ LV   
Sbjct: 337 ENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENL---GNGTSLPVLEGQSLRLVCVT 393

Query: 154 QNSP 157
            +SP
Sbjct: 394 HSSP 397


>gi|169214048 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 881

 Score = 37.4 bits (85), Expect = 0.021
 Identities = 30/87 (34%), Positives = 40/87 (45%), Gaps = 12/87 (13%)

Query: 40  GDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRA 99
           G +VTL C        A + W L  PA  + P+     G RLLL +V    +G Y+C  A
Sbjct: 421 GSNVTLRCAAAS-RPPADITWSLADPAEAAVPA-----GSRLLLPAVGPGHAGTYACLAA 474

Query: 100 G-----RPAGTVHLLV-DVPPEEPQLS 120
                 R    ++L V D+PP  PQ S
Sbjct: 475 NPRTGRRRRSLLNLTVADLPPGAPQCS 501


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.131    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,630,774
Number of Sequences: 37866
Number of extensions: 822275
Number of successful extensions: 2887
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 2569
Number of HSP's gapped (non-prelim): 399
length of query: 365
length of database: 18,247,518
effective HSP length: 104
effective length of query: 261
effective length of database: 14,309,454
effective search space: 3734767494
effective search space used: 3734767494
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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