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Search of human proteins with 31317249
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31317249 interleukin 6 receptor isoform 2 precursor [Homo
sapiens]
(365 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31317249 interleukin 6 receptor isoform 2 precursor [Homo sap... 759 0.0
gi|4504673 interleukin 6 receptor isoform 1 precursor [Homo sapi... 739 0.0
gi|218505839 interleukin 11 receptor, alpha isoform 1 precursor ... 119 3e-27
gi|22212922 interleukin 11 receptor, alpha isoform 2 precursor [... 119 3e-27
gi|4758594 interleukin 11 receptor, alpha isoform 1 precursor [H... 119 3e-27
gi|22212918 ciliary neurotrophic factor receptor preproprotein [... 105 6e-23
gi|4502931 ciliary neurotrophic factor receptor preproprotein [H... 105 6e-23
gi|4758062 cytokine receptor-like factor 1 [Homo sapiens] 67 3e-11
gi|24497438 interleukin 12B precursor [Homo sapiens] 65 1e-10
gi|28610149 interleukin 6 signal transducer isoform 2 precursor ... 58 2e-08
gi|28610147 interleukin 6 signal transducer isoform 1 precursor ... 58 2e-08
gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens] 55 1e-07
gi|4506107 prolactin receptor [Homo sapiens] 51 1e-06
gi|14577917 Epstein-Barr virus induced 3 precursor [Homo sapiens] 50 2e-06
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 45 1e-04
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 45 1e-04
gi|51093381 leptin receptor isoform 3 [Homo sapiens] 41 0.002
gi|51093379 leptin receptor isoform 2 [Homo sapiens] 41 0.002
gi|40254464 leptin receptor isoform 1 [Homo sapiens] 41 0.002
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 40 0.003
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 40 0.003
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 40 0.003
gi|115430248 gp130-like monocyte receptor [Homo sapiens] 40 0.003
gi|110349719 titin isoform N2-A [Homo sapiens] 40 0.004
gi|110349717 titin isoform novex-2 [Homo sapiens] 40 0.004
gi|110349713 titin isoform novex-1 [Homo sapiens] 40 0.004
gi|110349715 titin isoform N2-B [Homo sapiens] 40 0.004
gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Ho... 39 0.010
gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Ho... 39 0.010
gi|169214048 PREDICTED: hypothetical protein [Homo sapiens] 37 0.021
>gi|31317249 interleukin 6 receptor isoform 2 precursor [Homo
sapiens]
Length = 365
Score = 759 bits (1961), Expect = 0.0
Identities = 365/365 (100%), Positives = 365/365 (100%)
Query: 1 MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW 60
MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW
Sbjct: 1 MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW 60
Query: 61 VLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS 120
VLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS
Sbjct: 61 VLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS 120
Query: 121 CFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAV 180
CFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAV
Sbjct: 121 CFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAV 180
Query: 181 PEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQD 240
PEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQD
Sbjct: 181 PEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQD 240
Query: 241 PHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ 300
PHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ
Sbjct: 241 PHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ 300
Query: 301 GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPGSRRR 360
GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPGSRRR
Sbjct: 301 GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPGSRRR 360
Query: 361 GSCGL 365
GSCGL
Sbjct: 361 GSCGL 365
>gi|4504673 interleukin 6 receptor isoform 1 precursor [Homo
sapiens]
Length = 468
Score = 739 bits (1907), Expect = 0.0
Identities = 355/355 (100%), Positives = 355/355 (100%)
Query: 1 MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW 60
MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW
Sbjct: 1 MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW 60
Query: 61 VLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS 120
VLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS
Sbjct: 61 VLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS 120
Query: 121 CFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAV 180
CFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAV
Sbjct: 121 CFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAV 180
Query: 181 PEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQD 240
PEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQD
Sbjct: 181 PEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQD 240
Query: 241 PHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ 300
PHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ
Sbjct: 241 PHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ 300
Query: 301 GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLP 355
GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLP
Sbjct: 301 GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLP 355
>gi|218505839 interleukin 11 receptor, alpha isoform 1 precursor
[Homo sapiens]
Length = 422
Score = 119 bits (299), Expect = 3e-27
Identities = 102/329 (31%), Positives = 143/329 (43%), Gaps = 26/329 (7%)
Query: 2 LAVGCALLAALLAAPGAAL--APRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVH 59
++ C+ L+ +L A AL A CP GV PG SV L CPGV D V
Sbjct: 1 MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGD--PVS 58
Query: 60 WVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRA-GRPAGTVHLLVDVPPEEP 117
W +P P +G+G L+L D G Y C G GTV L + PP P
Sbjct: 59 WFRDGEPKLLQGPD--SGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARP 116
Query: 118 QLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQE-------PCQYSQE 170
+SC + + N C W P L T+ + RK A+ + PC
Sbjct: 117 VVSC-QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCP---- 171
Query: 171 SQKFSCQLAVPEGDS--SFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVA 228
V G S Y +++ + +G+ ++ IL+PDPP + V +V
Sbjct: 172 QDPLGAARCVVHGAEFWSQYRINVTEVNPLGAS-TRLLDVSLQSILRPDPPQGLRVESVP 230
Query: 229 RNPRWLSVTWQDPHSWNSS-FYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLR 287
PR L +W P SW + L+F L+YR + ++T L+ VI DA +GL
Sbjct: 231 GYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEE--VITDAVAGLP 288
Query: 288 HVVQLRAQEEFGQGEWSEWSPEAMGTPWT 316
H V++ A++ G WS WSPEA GTP T
Sbjct: 289 HAVRVSARDFLDAGTWSTWSPEAWGTPST 317
>gi|22212922 interleukin 11 receptor, alpha isoform 2 precursor
[Homo sapiens]
Length = 390
Score = 119 bits (299), Expect = 3e-27
Identities = 102/329 (31%), Positives = 143/329 (43%), Gaps = 26/329 (7%)
Query: 2 LAVGCALLAALLAAPGAAL--APRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVH 59
++ C+ L+ +L A AL A CP GV PG SV L CPGV D V
Sbjct: 1 MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGD--PVS 58
Query: 60 WVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRA-GRPAGTVHLLVDVPPEEP 117
W +P P +G+G L+L D G Y C G GTV L + PP P
Sbjct: 59 WFRDGEPKLLQGPD--SGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARP 116
Query: 118 QLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQE-------PCQYSQE 170
+SC + + N C W P L T+ + RK A+ + PC
Sbjct: 117 VVSC-QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCP---- 171
Query: 171 SQKFSCQLAVPEGDS--SFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVA 228
V G S Y +++ + +G+ ++ IL+PDPP + V +V
Sbjct: 172 QDPLGAARCVVHGAEFWSQYRINVTEVNPLGAS-TRLLDVSLQSILRPDPPQGLRVESVP 230
Query: 229 RNPRWLSVTWQDPHSWNSS-FYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLR 287
PR L +W P SW + L+F L+YR + ++T L+ VI DA +GL
Sbjct: 231 GYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEE--VITDAVAGLP 288
Query: 288 HVVQLRAQEEFGQGEWSEWSPEAMGTPWT 316
H V++ A++ G WS WSPEA GTP T
Sbjct: 289 HAVRVSARDFLDAGTWSTWSPEAWGTPST 317
>gi|4758594 interleukin 11 receptor, alpha isoform 1 precursor [Homo
sapiens]
Length = 422
Score = 119 bits (299), Expect = 3e-27
Identities = 102/329 (31%), Positives = 143/329 (43%), Gaps = 26/329 (7%)
Query: 2 LAVGCALLAALLAAPGAAL--APRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVH 59
++ C+ L+ +L A AL A CP GV PG SV L CPGV D V
Sbjct: 1 MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGD--PVS 58
Query: 60 WVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRA-GRPAGTVHLLVDVPPEEP 117
W +P P +G+G L+L D G Y C G GTV L + PP P
Sbjct: 59 WFRDGEPKLLQGPD--SGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARP 116
Query: 118 QLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQE-------PCQYSQE 170
+SC + + N C W P L T+ + RK A+ + PC
Sbjct: 117 VVSC-QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCP---- 171
Query: 171 SQKFSCQLAVPEGDS--SFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVA 228
V G S Y +++ + +G+ ++ IL+PDPP + V +V
Sbjct: 172 QDPLGAARCVVHGAEFWSQYRINVTEVNPLGAS-TRLLDVSLQSILRPDPPQGLRVESVP 230
Query: 229 RNPRWLSVTWQDPHSWNSS-FYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLR 287
PR L +W P SW + L+F L+YR + ++T L+ VI DA +GL
Sbjct: 231 GYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEE--VITDAVAGLP 288
Query: 288 HVVQLRAQEEFGQGEWSEWSPEAMGTPWT 316
H V++ A++ G WS WSPEA GTP T
Sbjct: 289 HAVRVSARDFLDAGTWSTWSPEAWGTPST 317
>gi|22212918 ciliary neurotrophic factor receptor preproprotein
[Homo sapiens]
Length = 372
Score = 105 bits (262), Expect = 6e-23
Identities = 106/358 (29%), Positives = 153/358 (42%), Gaps = 32/358 (8%)
Query: 11 ALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSH 70
A+LAA A + +R QE L G VTL C G D A V W + G+
Sbjct: 11 AVLAAAAAVVYAQRHSPQEAPHVQYERL-GSDVTLPC-GTANWD-AAVTWRVN----GTD 63
Query: 71 PSRWAGMGRRLLLRSVQLHDSGNYSCYR--AGRPAGTVHLLVDVPPEEPQLSCFRKSPLS 128
+ G +L+L ++L SG Y+C+ + V L V +PP EP LSC +
Sbjct: 64 LAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPK 123
Query: 129 NVVCEWG---PRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDS 185
C W P P+ VL K C+ + K C + S
Sbjct: 124 GFYCSWHLPTPTYIPNTFNVTVLHGSKIM---------VCE-KDPALKNRCHIRYMHLFS 173
Query: 186 SF-YIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSW 244
+ Y VS+ V++++G + TF I++PDPP N+ V NPR L VTWQ P +W
Sbjct: 174 TIKYKVSISVSNALGHNATAI-TFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTW 232
Query: 245 -NSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEW 303
+ + L+F LRYR + + D H I DA++G +++Q+ A++ G W
Sbjct: 233 PDPESFPLKFFLRYRPLILDQWQHVELSDGTAH-TITDAYAGKEYIIQVAAKDN-EIGTW 290
Query: 304 SEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPGSRRRG 361
S+WS A TPWTE ++T QA T + L PG G
Sbjct: 291 SDWSVAAHATPWTEE-----PRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSG 343
>gi|4502931 ciliary neurotrophic factor receptor preproprotein [Homo
sapiens]
Length = 372
Score = 105 bits (262), Expect = 6e-23
Identities = 106/358 (29%), Positives = 153/358 (42%), Gaps = 32/358 (8%)
Query: 11 ALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSH 70
A+LAA A + +R QE L G VTL C G D A V W + G+
Sbjct: 11 AVLAAAAAVVYAQRHSPQEAPHVQYERL-GSDVTLPC-GTANWD-AAVTWRVN----GTD 63
Query: 71 PSRWAGMGRRLLLRSVQLHDSGNYSCYR--AGRPAGTVHLLVDVPPEEPQLSCFRKSPLS 128
+ G +L+L ++L SG Y+C+ + V L V +PP EP LSC +
Sbjct: 64 LAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPK 123
Query: 129 NVVCEWG---PRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDS 185
C W P P+ VL K C+ + K C + S
Sbjct: 124 GFYCSWHLPTPTYIPNTFNVTVLHGSKIM---------VCE-KDPALKNRCHIRYMHLFS 173
Query: 186 SF-YIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSW 244
+ Y VS+ V++++G + TF I++PDPP N+ V NPR L VTWQ P +W
Sbjct: 174 TIKYKVSISVSNALGHNATAI-TFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTW 232
Query: 245 -NSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEW 303
+ + L+F LRYR + + D H I DA++G +++Q+ A++ G W
Sbjct: 233 PDPESFPLKFFLRYRPLILDQWQHVELSDGTAH-TITDAYAGKEYIIQVAAKDN-EIGTW 290
Query: 304 SEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPGSRRRG 361
S+WS A TPWTE ++T QA T + L PG G
Sbjct: 291 SDWSVAAHATPWTEE-----PRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSG 343
>gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]
Length = 422
Score = 67.0 bits (162), Expect = 3e-11
Identities = 84/335 (25%), Positives = 126/335 (37%), Gaps = 32/335 (9%)
Query: 9 LAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTC------PGVEPEDNATVHWVL 62
L LL GA A ++ T L G S+ TC PG E ++W L
Sbjct: 22 LLLLLCVLGAPRAGSGAHTAVISPQDPTLLIGSSLLATCSVHGDPPGATAEG---LYWTL 78
Query: 63 RKPAAGSHPSRWAGMGRRLL----LRSVQLHDSGNYSCY-RAGRPAGTVHLLVDVPPEEP 117
SR L L + N C+ R G L V +PPE+P
Sbjct: 79 NGRRLPPELSRVLNASTLALALANLNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKP 138
Query: 118 -QLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSC 176
+SC+ K+ + ++ C W P + ++ +D C+ SC
Sbjct: 139 VNISCWSKN-MKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQD--NTCEEYHTVGPHSC 195
Query: 177 QLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSV 236
+ + Y + + + +GS S T ++ DPP ++ V+ V LSV
Sbjct: 196 HIPKDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSV 255
Query: 237 TWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKD---LQHHCVIHDAWSGLRHVVQLR 293
W P + ++ ++++RYR E S W V D Q C + G + VQ+R
Sbjct: 256 RWVSPPALKDFLFQAKYQIRYRVEDS---VDWKVVDDVSNQTSCRLAGLKPGTVYFVQVR 312
Query: 294 AQEEFG------QGEWSEWS-PEAMGTPWTESRSP 321
FG G WSEWS P A TP +E P
Sbjct: 313 C-NPFGIYGSKKAGIWSEWSHPTAASTPRSERPGP 346
>gi|24497438 interleukin 12B precursor [Homo sapiens]
Length = 328
Score = 65.1 bits (157), Expect = 1e-10
Identities = 77/329 (23%), Positives = 128/329 (38%), Gaps = 55/329 (16%)
Query: 13 LAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPS 72
LA+P A+ + V PG+ V LTC E ED T W L S
Sbjct: 16 LASPLVAIWELKKDVYVVELDWYPDAPGEMVVLTCDTPE-EDGIT--WTL------DQSS 66
Query: 73 RWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLV----------DV------PPEE 116
G G+ L ++ + D+G Y+C++ G LL+ D+ P +
Sbjct: 67 EVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKDQKEPKNK 126
Query: 117 PQLSCFRKSPLSNVVCEW----------------GPRSTPSLTTKAVLLVRKFQNSPAED 160
L C K+ C W G +T A L + ++
Sbjct: 127 TFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERVRGDNKE 186
Query: 161 FQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPA 220
+ +YS E Q+ S A P + S I M A + T +F I++PDPP
Sbjct: 187 Y----EYSVECQEDS---ACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPK 239
Query: 221 NITVTAVARNPRWLSVTWQDPHSWNS--SFYRLRFELRYRAERSKTFTTWMVKDLQHHCV 278
N+ + + +N R + V+W+ P +W++ S++ L F ++ + + + + D V
Sbjct: 240 NLQLKPL-KNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATV 298
Query: 279 IHDAWSGLRHVVQLRAQEEFGQGEWSEWS 307
I + +RAQ+ + WSEW+
Sbjct: 299 I----CRKNASISVRAQDRYYSSSWSEWA 323
>gi|28610149 interleukin 6 signal transducer isoform 2 precursor
[Homo sapiens]
Length = 329
Score = 57.8 bits (138), Expect = 2e-08
Identities = 55/225 (24%), Positives = 100/225 (44%), Gaps = 29/225 (12%)
Query: 106 VHLLVDVPPEEPQ-LSCFRKSPLSNVVCEW-GPRST---PSLTTKAVLLVRKFQNSPAED 160
+ ++ +PPE+P+ LSC + CEW G R T + T K+ KF + A+
Sbjct: 118 ITIISGLPPEKPKNLSCIVNEG-KKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAK- 175
Query: 161 FQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCV----ASSVGSKFSKTQTFQGCGILQP 216
SC + S+ Y V++ V +++G S F ++P
Sbjct: 176 ---------RDTPTSCTVDY----STVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKP 222
Query: 217 DPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDL--- 273
+PP N++V L +TW +P S L++ ++YR + + T++ +D
Sbjct: 223 NPPHNLSVINSEELSSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQIPPEDTAST 280
Query: 274 QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTES 318
+ + D +V ++R +E G+G WS+WS EA G + ++
Sbjct: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDN 325
>gi|28610147 interleukin 6 signal transducer isoform 1 precursor
[Homo sapiens]
Length = 918
Score = 57.8 bits (138), Expect = 2e-08
Identities = 56/227 (24%), Positives = 100/227 (44%), Gaps = 29/227 (12%)
Query: 106 VHLLVDVPPEEPQ-LSCFRKSPLSNVVCEW-GPRST---PSLTTKAVLLVRKFQNSPAED 160
+ ++ +PPE+P+ LSC + CEW G R T + T K+ KF + A+
Sbjct: 118 ITIISGLPPEKPKNLSCIVNEG-KKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAK- 175
Query: 161 FQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCV----ASSVGSKFSKTQTFQGCGILQP 216
SC + S+ Y V++ V +++G S F ++P
Sbjct: 176 ---------RDTPTSCTVDY----STVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKP 222
Query: 217 DPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDL--- 273
+PP N++V L +TW +P S L++ ++YR + + T++ +D
Sbjct: 223 NPPHNLSVINSEELSSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQIPPEDTAST 280
Query: 274 QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRS 320
+ + D +V ++R +E G+G WS+WS EA G + + S
Sbjct: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPS 327
>gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]
Length = 862
Score = 54.7 bits (130), Expect = 1e-07
Identities = 51/202 (25%), Positives = 83/202 (41%), Gaps = 12/202 (5%)
Query: 108 LLVDVPPEEPQ-LSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQ 166
+ V V PE+PQ LSC +K V C W L T+ L + +N +Q+ C+
Sbjct: 118 IFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLT---WQKQCK 174
Query: 167 YSQ-ESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVT 225
+ F L PE S + + +S+GS S TF I++P PP +I +
Sbjct: 175 DIYCDYLDFGINLT-PESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIK 233
Query: 226 AVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSG 285
+ ++ W+D L LRYR S+ + V + + D
Sbjct: 234 FQKASVSRCTLYWRD------EGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPF 287
Query: 286 LRHVVQLRAQEEFGQGEWSEWS 307
+ Q+ ++ +G WS+WS
Sbjct: 288 TEYEFQISSKLHLYKGSWSDWS 309
>gi|4506107 prolactin receptor [Homo sapiens]
Length = 622
Score = 51.2 bits (121), Expect = 1e-06
Identities = 47/202 (23%), Positives = 76/202 (37%), Gaps = 12/202 (5%)
Query: 112 VPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQES 171
+PP +P++ R C W P + L T L + E C
Sbjct: 26 LPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHR----EGETLMHECPDYITG 81
Query: 172 QKFSCQLAVPEGDS-SFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARN 230
SC YI+ + + +GS FS I+QPDPP + V
Sbjct: 82 GPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPE 141
Query: 231 PR--WLSVTWQDPH--SWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGL 286
R +L + W P + ++ L +E+R + E++ + Q I G
Sbjct: 142 DRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQ-QTEFKILSLHPGQ 200
Query: 287 RHVVQLRAQEEFGQGEWSEWSP 308
+++VQ+R + + G WS WSP
Sbjct: 201 KYLVQVRCKPD--HGYWSAWSP 220
>gi|14577917 Epstein-Barr virus induced 3 precursor [Homo sapiens]
Length = 229
Score = 50.4 bits (119), Expect = 2e-06
Identities = 49/207 (23%), Positives = 85/207 (41%), Gaps = 23/207 (11%)
Query: 117 PQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSC 176
P++ C V C W P+ T+ + A PC Q SC
Sbjct: 31 PRVQCRASRYPIAVDCSWTLPPAPNSTSPVSFIATYRLGMAARGHSWPC-LQQTPTSTSC 89
Query: 177 QLA-VPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLS 235
+ V + Y++++ GS S F I++PDPP + ++ +A R L
Sbjct: 90 TITDVQLFSMAPYVLNVTAVHPWGSS-SSFVPFITEHIIKPDPPEGVRLSPLAE--RQLQ 146
Query: 236 VTWQDPHSWN-SSFYRLRFELRYRAERSKTF--------TTWMVKDLQHHCVIHDAWSGL 286
V W+ P SW + L++ +RY+ + + F T+++++ ++
Sbjct: 147 VQWEPPGSWPFPEIFSLKYWIRYKRQGAARFHRVGPIEATSFILRAVRPRA--------- 197
Query: 287 RHVVQLRAQEEFGQGEWSEWSPEAMGT 313
R+ VQ+ AQ+ GE S+WS A T
Sbjct: 198 RYYVQVAAQDLTDYGELSDWSLPATAT 224
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 45.1 bits (105), Expect = 1e-04
Identities = 78/326 (23%), Positives = 123/326 (37%), Gaps = 47/326 (14%)
Query: 33 GVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRR-------LLLRS 85
G +T+ + L C V + + V W+ K + G+ PS GRR ++R+
Sbjct: 1293 GTVTTPWMKDIVLPCKAVG-DPSPAVKWM--KDSNGT-PSLVTIDGRRSIFSNGSFIIRT 1348
Query: 86 VQLHDSGNYSCY---RAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSL 142
V+ DSG YSC G ++L V VPP++P+L+ K+ S++ W P
Sbjct: 1349 VKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLT-VSKTTSSSITLSWLPGDNGGS 1407
Query: 143 TTKAVLLVRKFQNSPA-EDFQ-EPCQYSQESQKFSC------QLAVPEGDSSFYIVSMCV 194
+ + +L NS F P + S + C L G I +
Sbjct: 1408 SIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIE 1467
Query: 195 ASSVGS--KFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLR 252
A ++G +FSK Q A+I T V N + W D +S
Sbjct: 1468 AKTLGKEPQFSKEQELF----------ASINTTRVRLN----LIGWNDGGCPITS----- 1508
Query: 253 FELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMG 312
F L YR + +TT L +++D + +Q+R G +E
Sbjct: 1509 FTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAG---CAEKQANFAT 1565
Query: 313 TPWTESRSPPAENEVSTPMQALTTNK 338
+ S PP V + LTTN+
Sbjct: 1566 LNYDGSTIPPLIKSVVQNEEGLTTNE 1591
Score = 29.3 bits (64), Expect = 5.8
Identities = 32/174 (18%), Positives = 64/174 (36%), Gaps = 12/174 (6%)
Query: 90 DSGNYSCYRA---GRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKA 146
DSG +SC+ G G + L V PP+ P++ + + W T +
Sbjct: 859 DSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIE-IKDVKARTITLRW----TMGFDGNS 913
Query: 147 VLLVRKFQNSPAEDFQEPCQYSQE-SQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKT 205
+ + D + Q +++ S + + + SS Y + M + +G
Sbjct: 914 PITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN 973
Query: 206 QTFQGCGILQPD-PPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYR 258
+ PD PP + + ++ + VTW+ P + +++ YR
Sbjct: 974 ELTITADEAAPDGPPQEVHLEPISSQS--IRVTWKAPKKHLQNGIIRGYQIGYR 1025
Score = 28.9 bits (63), Expect = 7.6
Identities = 35/137 (25%), Positives = 54/137 (39%), Gaps = 23/137 (16%)
Query: 81 LLLRSVQLHDSGNYSCYRAGRPAGTVH---LLVDVPPE-----EPQLSCFRKSPLSNVVC 132
L + ++ L +GNY+C A H L+V VPP+ Q + K+ + N
Sbjct: 654 LRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSA 713
Query: 133 EWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFS----CQLAVPEGDSSFY 188
E P T +V KF +P + Q S V E DS +Y
Sbjct: 714 EGYPVPT---------IVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYY 764
Query: 189 IVSMCVASSVGSKFSKT 205
+ V++ VG+ SK+
Sbjct: 765 LCK--VSNDVGADVSKS 779
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 45.1 bits (105), Expect = 1e-04
Identities = 36/125 (28%), Positives = 57/125 (45%), Gaps = 14/125 (11%)
Query: 81 LLLRSVQLHDSGNYSCYRA---GRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPR 137
LLLR+V+ DSG Y+C G V+LLV VPP++P+L+ K+ S++ W P
Sbjct: 1408 LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLT-VSKTSASSITLTWIPG 1466
Query: 138 STPSLTTKAVLLVRKFQNSP--AEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVA 195
+ + +L NS + F + S + C ++Y V +
Sbjct: 1467 DNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKC--------GTWYKVKLAAK 1518
Query: 196 SSVGS 200
+SVGS
Sbjct: 1519 NSVGS 1523
Score = 30.4 bits (67), Expect = 2.6
Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 10/165 (6%)
Query: 81 LLLRSVQLHDSGNYSCYRA---GRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPR 137
L L+ DS +SC+ G G + L V PP+ P+L R+ ++ W R
Sbjct: 912 LKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELE-IREVKARSMNLRWTQR 970
Query: 138 STPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASS 197
+ + K S + DF++ + S + V +S Y + M +
Sbjct: 971 FDGNSIITGFDIEYK-NKSDSWDFKQSTR--NISPTINQANIVDLHPASVYSIRMYSFNK 1027
Query: 198 VG-SKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDP 241
+G S+ SK T PP ++T+ V + VTW+ P
Sbjct: 1028 IGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQS--IQVTWKAP 1070
>gi|51093381 leptin receptor isoform 3 [Homo sapiens]
Length = 958
Score = 40.8 bits (94), Expect = 0.002
Identities = 44/200 (22%), Positives = 83/200 (41%), Gaps = 12/200 (6%)
Query: 119 LSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNS-------PAEDFQEPCQYSQES 171
+SC L+ + C W + SL ++ L +R ++S EP +S
Sbjct: 434 ISCETDGYLTKMTCRWSTSTIQSLA-ESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQS 492
Query: 172 QKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNP 231
F + P S Y + + + S+GS S +++P PP+++ + N
Sbjct: 493 DGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAE-ITINI 551
Query: 232 RWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVV 290
L ++W+ P N+ +++R+ L + + K + + K + D + + V
Sbjct: 552 GLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAV--YAV 609
Query: 291 QLRAQEEFGQGEWSEWSPEA 310
Q+R + G G WS WS A
Sbjct: 610 QVRCKRLDGLGYWSNWSNPA 629
Score = 35.4 bits (80), Expect = 0.081
Identities = 34/153 (22%), Positives = 63/153 (41%), Gaps = 16/153 (10%)
Query: 176 CQLAVPEGDSSFYIVSMCVASSVGSKF-SKTQTFQGCGILQPDPPANITVTAVARNPRWL 234
C + VP + ++ +S G F S + Q +++PDPP + + L
Sbjct: 196 CLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--L 253
Query: 235 SVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH-----HCVIHDAWSGLRHV 289
++W P + F L+Y+ + S+ TT ++++ ++ G +
Sbjct: 254 KISWSSPPL-------VPFPLQYQVKYSENSTT-VIREADKIVSATSLLVDSILPGSSYE 305
Query: 290 VQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPP 322
VQ+R + G G WS+WS + T PP
Sbjct: 306 VQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPP 338
>gi|51093379 leptin receptor isoform 2 [Homo sapiens]
Length = 896
Score = 40.8 bits (94), Expect = 0.002
Identities = 44/200 (22%), Positives = 83/200 (41%), Gaps = 12/200 (6%)
Query: 119 LSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNS-------PAEDFQEPCQYSQES 171
+SC L+ + C W + SL ++ L +R ++S EP +S
Sbjct: 434 ISCETDGYLTKMTCRWSTSTIQSLA-ESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQS 492
Query: 172 QKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNP 231
F + P S Y + + + S+GS S +++P PP+++ + N
Sbjct: 493 DGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAE-ITINI 551
Query: 232 RWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVV 290
L ++W+ P N+ +++R+ L + + K + + K + D + + V
Sbjct: 552 GLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAV--YAV 609
Query: 291 QLRAQEEFGQGEWSEWSPEA 310
Q+R + G G WS WS A
Sbjct: 610 QVRCKRLDGLGYWSNWSNPA 629
Score = 35.4 bits (80), Expect = 0.081
Identities = 34/153 (22%), Positives = 63/153 (41%), Gaps = 16/153 (10%)
Query: 176 CQLAVPEGDSSFYIVSMCVASSVGSKF-SKTQTFQGCGILQPDPPANITVTAVARNPRWL 234
C + VP + ++ +S G F S + Q +++PDPP + + L
Sbjct: 196 CLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--L 253
Query: 235 SVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH-----HCVIHDAWSGLRHV 289
++W P + F L+Y+ + S+ TT ++++ ++ G +
Sbjct: 254 KISWSSPPL-------VPFPLQYQVKYSENSTT-VIREADKIVSATSLLVDSILPGSSYE 305
Query: 290 VQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPP 322
VQ+R + G G WS+WS + T PP
Sbjct: 306 VQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPP 338
>gi|40254464 leptin receptor isoform 1 [Homo sapiens]
Length = 1165
Score = 40.8 bits (94), Expect = 0.002
Identities = 44/200 (22%), Positives = 83/200 (41%), Gaps = 12/200 (6%)
Query: 119 LSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNS-------PAEDFQEPCQYSQES 171
+SC L+ + C W + SL ++ L +R ++S EP +S
Sbjct: 434 ISCETDGYLTKMTCRWSTSTIQSLA-ESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQS 492
Query: 172 QKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNP 231
F + P S Y + + + S+GS S +++P PP+++ + N
Sbjct: 493 DGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAE-ITINI 551
Query: 232 RWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVV 290
L ++W+ P N+ +++R+ L + + K + + K + D + + V
Sbjct: 552 GLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAV--YAV 609
Query: 291 QLRAQEEFGQGEWSEWSPEA 310
Q+R + G G WS WS A
Sbjct: 610 QVRCKRLDGLGYWSNWSNPA 629
Score = 35.4 bits (80), Expect = 0.081
Identities = 34/153 (22%), Positives = 63/153 (41%), Gaps = 16/153 (10%)
Query: 176 CQLAVPEGDSSFYIVSMCVASSVGSKF-SKTQTFQGCGILQPDPPANITVTAVARNPRWL 234
C + VP + ++ +S G F S + Q +++PDPP + + L
Sbjct: 196 CLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--L 253
Query: 235 SVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH-----HCVIHDAWSGLRHV 289
++W P + F L+Y+ + S+ TT ++++ ++ G +
Sbjct: 254 KISWSSPPL-------VPFPLQYQVKYSENSTT-VIREADKIVSATSLLVDSILPGSSYE 305
Query: 290 VQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPP 322
VQ+R + G G WS+WS + T PP
Sbjct: 306 VQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPP 338
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 40.4 bits (93), Expect = 0.003
Identities = 32/87 (36%), Positives = 40/87 (45%), Gaps = 7/87 (8%)
Query: 33 GVLTSLPGDSVTLTCPGVEPEDNATVHWVL-RKPAAGSHPSRWAGMGRRLLLRSVQLHDS 91
G L S PG+ VT+ CP V V W+ P S + G G L + VQL D+
Sbjct: 2130 GTLVSRPGELVTMVCP-VRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADA 2188
Query: 92 GNYSCYRAGRPAGTVH----LLVDVPP 114
G ++C A PAG L V VPP
Sbjct: 2189 GIFTCV-AASPAGVADRNFTLQVQVPP 2214
Score = 34.7 bits (78), Expect = 0.14
Identities = 34/89 (38%), Positives = 40/89 (44%), Gaps = 21/89 (23%)
Query: 38 LPGDSVTLTC--PGVEPEDNATVHWVLRKPAAGSHP-SRWAGM-----GRRLLLRSVQLH 89
L SVTL C GV P D V W G P S W G+ GR L + QL
Sbjct: 707 LENASVTLECLASGVPPPD---VSWF-----KGHQPVSSWMGVTVSVDGRVLRIEQAQLS 758
Query: 90 DSGNYSCYRAGRPAGTVH----LLVDVPP 114
D+G+Y C A AG+ L V+VPP
Sbjct: 759 DAGSYRCV-ASNVAGSTELRYGLRVNVPP 786
Score = 32.7 bits (73), Expect = 0.53
Identities = 28/95 (29%), Positives = 41/95 (43%), Gaps = 9/95 (9%)
Query: 26 PAQEVARGVLTSLPGDSVTLTCPG--VEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLL 82
P EV + + ++TL C V P T+ W +P S + G GR L
Sbjct: 1449 PLGEVGVKEVKTKVNSTLTLECESWAVPPP---TIRWYKDGQPVTPSSRLQVLGEGRLLQ 1505
Query: 83 LRSVQLHDSGNYSCYR---AGRPAGTVHLLVDVPP 114
++ Q+ DSG Y C AG ++L+ VPP
Sbjct: 1506 IQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 1540
Score = 32.3 bits (72), Expect = 0.69
Identities = 34/113 (30%), Positives = 50/113 (44%), Gaps = 11/113 (9%)
Query: 40 GDSVTLTCPGVEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSC-- 96
GD L+C + TV W +P + ++ G+RL ++ Q+ D G YSC
Sbjct: 1856 GDKAVLSCE-TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKV 1914
Query: 97 -YRAGRPAGTVHLLVDVPP--EEPQ---LSCFRKSPLSNVVCEWGPRSTPSLT 143
AG T L V VPP E P+ +S SPL + C+ P++T
Sbjct: 1915 SNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLV-LTCDVSGVPAPTVT 1966
Score = 30.0 bits (66), Expect = 3.4
Identities = 26/79 (32%), Positives = 33/79 (41%), Gaps = 7/79 (8%)
Query: 21 APRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW---VLRKPAAGSHPSRWAGM 77
AP R V+ PG V EP T H VL++ A P R
Sbjct: 2387 APPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPER---- 2442
Query: 78 GRRLLLRSVQLHDSGNYSC 96
GR L L+++ DSG+YSC
Sbjct: 2443 GRFLQLQALSTADSGDYSC 2461
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 40.4 bits (93), Expect = 0.003
Identities = 32/87 (36%), Positives = 40/87 (45%), Gaps = 7/87 (8%)
Query: 33 GVLTSLPGDSVTLTCPGVEPEDNATVHWVL-RKPAAGSHPSRWAGMGRRLLLRSVQLHDS 91
G L S PG+ VT+ CP V V W+ P S + G G L + VQL D+
Sbjct: 3321 GTLVSRPGELVTMVCP-VRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADA 3379
Query: 92 GNYSCYRAGRPAGTVH----LLVDVPP 114
G ++C A PAG L V VPP
Sbjct: 3380 GIFTCV-AASPAGVADRNFTLQVQVPP 3405
Score = 34.7 bits (78), Expect = 0.14
Identities = 34/89 (38%), Positives = 40/89 (44%), Gaps = 21/89 (23%)
Query: 38 LPGDSVTLTC--PGVEPEDNATVHWVLRKPAAGSHP-SRWAGM-----GRRLLLRSVQLH 89
L SVTL C GV P D V W G P S W G+ GR L + QL
Sbjct: 1898 LENASVTLECLASGVPPPD---VSWF-----KGHQPVSSWMGVTVSVDGRVLRIEQAQLS 1949
Query: 90 DSGNYSCYRAGRPAGTVH----LLVDVPP 114
D+G+Y C A AG+ L V+VPP
Sbjct: 1950 DAGSYRCV-ASNVAGSTELRYGLRVNVPP 1977
Score = 32.7 bits (73), Expect = 0.53
Identities = 28/95 (29%), Positives = 41/95 (43%), Gaps = 9/95 (9%)
Query: 26 PAQEVARGVLTSLPGDSVTLTCPG--VEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLL 82
P EV + + ++TL C V P T+ W +P S + G GR L
Sbjct: 2640 PLGEVGVKEVKTKVNSTLTLECESWAVPPP---TIRWYKDGQPVTPSSRLQVLGEGRLLQ 2696
Query: 83 LRSVQLHDSGNYSCYR---AGRPAGTVHLLVDVPP 114
++ Q+ DSG Y C AG ++L+ VPP
Sbjct: 2697 IQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 2731
Score = 32.3 bits (72), Expect = 0.69
Identities = 34/113 (30%), Positives = 50/113 (44%), Gaps = 11/113 (9%)
Query: 40 GDSVTLTCPGVEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSC-- 96
GD L+C + TV W +P + ++ G+RL ++ Q+ D G YSC
Sbjct: 3047 GDKAVLSCE-TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKV 3105
Query: 97 -YRAGRPAGTVHLLVDVPP--EEPQ---LSCFRKSPLSNVVCEWGPRSTPSLT 143
AG T L V VPP E P+ +S SPL + C+ P++T
Sbjct: 3106 SNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLV-LTCDVSGVPAPTVT 3157
Score = 30.0 bits (66), Expect = 3.4
Identities = 26/79 (32%), Positives = 33/79 (41%), Gaps = 7/79 (8%)
Query: 21 APRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW---VLRKPAAGSHPSRWAGM 77
AP R V+ PG V EP T H VL++ A P R
Sbjct: 3578 APPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPER---- 3633
Query: 78 GRRLLLRSVQLHDSGNYSC 96
GR L L+++ DSG+YSC
Sbjct: 3634 GRFLQLQALSTADSGDYSC 3652
Score = 28.9 bits (63), Expect = 7.6
Identities = 18/39 (46%), Positives = 22/39 (56%), Gaps = 5/39 (12%)
Query: 81 LLLRSVQLHDSGNYSCYRAGRPAGTVH----LLVDVPPE 115
L L VQ+ DSG+Y C A PAG+ L V VPP+
Sbjct: 1084 LRLAQVQVGDSGHYEC-TASNPAGSASHRYVLGVQVPPQ 1121
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 40.4 bits (93), Expect = 0.003
Identities = 32/87 (36%), Positives = 40/87 (45%), Gaps = 7/87 (8%)
Query: 33 GVLTSLPGDSVTLTCPGVEPEDNATVHWVL-RKPAAGSHPSRWAGMGRRLLLRSVQLHDS 91
G L S PG+ VT+ CP V V W+ P S + G G L + VQL D+
Sbjct: 2039 GTLVSRPGELVTMVCP-VRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADA 2097
Query: 92 GNYSCYRAGRPAGTVH----LLVDVPP 114
G ++C A PAG L V VPP
Sbjct: 2098 GIFTCV-AASPAGVADRNFTLQVQVPP 2123
Score = 34.7 bits (78), Expect = 0.14
Identities = 34/89 (38%), Positives = 40/89 (44%), Gaps = 21/89 (23%)
Query: 38 LPGDSVTLTC--PGVEPEDNATVHWVLRKPAAGSHP-SRWAGM-----GRRLLLRSVQLH 89
L SVTL C GV P D V W G P S W G+ GR L + QL
Sbjct: 616 LENASVTLECLASGVPPPD---VSWF-----KGHQPVSSWMGVTVSVDGRVLRIEQAQLS 667
Query: 90 DSGNYSCYRAGRPAGTVH----LLVDVPP 114
D+G+Y C A AG+ L V+VPP
Sbjct: 668 DAGSYRCV-ASNVAGSTELRYGLRVNVPP 695
Score = 33.1 bits (74), Expect = 0.40
Identities = 28/95 (29%), Positives = 41/95 (43%), Gaps = 9/95 (9%)
Query: 26 PAQEVARGVLTSLPGDSVTLTCPG--VEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLL 82
P EV + + ++TL C V P T+ W +P S + G GR L
Sbjct: 1358 PLAEVGVKEVKTKVNSTLTLECESWAVPPP---TIRWYKDGQPVTPSSRLQVLGEGRLLQ 1414
Query: 83 LRSVQLHDSGNYSCYR---AGRPAGTVHLLVDVPP 114
++ Q+ DSG Y C AG ++L+ VPP
Sbjct: 1415 IQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 1449
Score = 32.3 bits (72), Expect = 0.69
Identities = 34/113 (30%), Positives = 50/113 (44%), Gaps = 11/113 (9%)
Query: 40 GDSVTLTCPGVEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSC-- 96
GD L+C + TV W +P + ++ G+RL ++ Q+ D G YSC
Sbjct: 1765 GDKAVLSCE-TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKV 1823
Query: 97 -YRAGRPAGTVHLLVDVPP--EEPQ---LSCFRKSPLSNVVCEWGPRSTPSLT 143
AG T L V VPP E P+ +S SPL + C+ P++T
Sbjct: 1824 SNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLV-LTCDVSGVPAPTVT 1875
Score = 30.0 bits (66), Expect = 3.4
Identities = 26/79 (32%), Positives = 33/79 (41%), Gaps = 7/79 (8%)
Query: 21 APRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW---VLRKPAAGSHPSRWAGM 77
AP R V+ PG V EP T H VL++ A P R
Sbjct: 2296 APPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPER---- 2351
Query: 78 GRRLLLRSVQLHDSGNYSC 96
GR L L+++ DSG+YSC
Sbjct: 2352 GRFLQLQALSTADSGDYSC 2370
>gi|115430248 gp130-like monocyte receptor [Homo sapiens]
Length = 764
Score = 40.4 bits (93), Expect = 0.003
Identities = 59/254 (23%), Positives = 94/254 (37%), Gaps = 49/254 (19%)
Query: 109 LVDVPPEEPQLSC---FRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKF--------QNSP 157
L +P + +SC +RK N+ C W P S T V F NS
Sbjct: 50 LAALPAKPENISCVYYYRK----NLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSS 105
Query: 158 AEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPD 217
+ + C + F ++ +P+ Y + + + G S ++ I + +
Sbjct: 106 TSENRASCSF------FLPRITIPDN----YTIEVEAENGDGVIKSHMTYWRLENIAKTE 155
Query: 218 PPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMV------- 270
PP V V R + + W P S L++ LR+R S T+WM
Sbjct: 156 PPKIFRVKPVLGIKRMIQIEWIKPELAPVSS-DLKYTLRFRTVNS---TSWMEVNFAKNR 211
Query: 271 KDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSP--------- 321
KD + +V+ LR + + WS+WS E MG TE +P
Sbjct: 212 KDKNQTYNLTGLQPFTEYVIALRCAVKESKF-WSDWSQEKMG--MTEEEAPCGLELWRVL 268
Query: 322 -PAENEVSTPMQAL 334
PAE + P++ L
Sbjct: 269 KPAEADGRRPVRLL 282
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 39.7 bits (91), Expect = 0.004
Identities = 35/120 (29%), Positives = 51/120 (42%), Gaps = 6/120 (5%)
Query: 216 PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAE-RSKTFTTWMVKDL 273
P PP N+T+T V N +S+TW+ P + + ELR + R T T +DL
Sbjct: 13191 PGPPLNVTITDV--NRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDL 13248
Query: 274 QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQA 333
+ D G + ++RAQ G G+ S +P E SPP S Q+
Sbjct: 13249 S--ATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQS 13306
Score = 31.6 bits (70), Expect = 1.2
Identities = 25/118 (21%), Positives = 50/118 (42%), Gaps = 8/118 (6%)
Query: 184 DSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHS 243
DS Y +++ +S S F + P PP N+ VT + ++ +S+TW+ P
Sbjct: 23007 DSGKYTLTLENSSGTKSAFVTVRVLD-----TPSPPVNLKVTEITKDS--VSITWEPPLL 23059
Query: 244 WNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQG 301
S + + + R K++ + ++ I G + ++ A+ E+G G
Sbjct: 23060 DGGSKIK-NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIG 23116
Score = 30.0 bits (66), Expect = 3.4
Identities = 41/189 (21%), Positives = 74/189 (39%), Gaps = 16/189 (8%)
Query: 160 DFQEPCQYSQESQKF----SCQLAVPEG---DSSFYIVSMCVASSVGSKFSKTQTFQGCG 212
D +EP Y K +C L +P+ D+ Y ++ +++G+ SK G
Sbjct: 16159 DNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTIT--AVNNLGTA-SKEMRLNVLG 16215
Query: 213 ILQPDPPAN-ITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVK 271
+P PP I +V+ + LS W P S + + R KT+ +
Sbjct: 16216 --RPGPPVGPIKFESVSADQMTLS--WFPPKDDGGSKIT-NYVIEKREANRKTWVHVSSE 16270
Query: 272 DLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPM 331
+ I G +V ++ AQ ++G GE + PE ++ +P S
Sbjct: 16271 PKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTR 16330
Query: 332 QALTTNKDD 340
++T N ++
Sbjct: 16331 NSMTVNWEE 16339
Score = 30.0 bits (66), Expect = 3.4
Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 13/101 (12%)
Query: 216 PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTW-MVKDL 273
P PP ITV V RN +S++W P H S +++ + +A+ S+ ++ VK L
Sbjct: 23131 PQPPGKITVDDVTRNS--VSLSWTKPEHDGGSKI--IQYIVEMQAKHSEKWSECARVKSL 23186
Query: 274 QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTP 314
Q VI + G ++ ++ A E G+ + P ++ P
Sbjct: 23187 Q--AVITNLTQGEEYLFRVVAVNEKGRSD-----PRSLAVP 23220
Score = 29.3 bits (64), Expect = 5.8
Identities = 20/90 (22%), Positives = 44/90 (48%), Gaps = 3/90 (3%)
Query: 216 PDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH 275
P PP N+TV ++++ + VTW+ P S + + ++ R K+++T + +
Sbjct: 19787 PGPPVNVTVKEISKDSAY--VTWEPPIIDGGSPI-INYVVQKRDAERKSWSTVTTECSKT 19843
Query: 276 HCVIHDAWSGLRHVVQLRAQEEFGQGEWSE 305
+ + G + ++ A+ E+G G+ E
Sbjct: 19844 SFRVANLEEGKSYFFRVFAENEYGIGDPGE 19873
Score = 28.9 bits (63), Expect = 7.6
Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 7/64 (10%)
Query: 180 VPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQ 239
V D+ FY+V C + G KT + PDPP + V+ V+R+ +++TW
Sbjct: 31091 VERKDAGFYVV--CAKNRFGID-QKTVELDVADV--PDPPRGVKVSDVSRDS--VNLTWT 31143
Query: 240 DPHS 243
+P S
Sbjct: 31144 EPAS 31147
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 39.7 bits (91), Expect = 0.004
Identities = 35/120 (29%), Positives = 51/120 (42%), Gaps = 6/120 (5%)
Query: 216 PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAE-RSKTFTTWMVKDL 273
P PP N+T+T V N +S+TW+ P + + ELR + R T T +DL
Sbjct: 6886 PGPPLNVTITDV--NRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDL 6943
Query: 274 QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQA 333
+ D G + ++RAQ G G+ S +P E SPP S Q+
Sbjct: 6944 S--ATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQS 7001
Score = 31.6 bits (70), Expect = 1.2
Identities = 25/118 (21%), Positives = 50/118 (42%), Gaps = 8/118 (6%)
Query: 184 DSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHS 243
DS Y +++ +S S F + P PP N+ VT + ++ +S+TW+ P
Sbjct: 16702 DSGKYTLTLENSSGTKSAFVTVRVLD-----TPSPPVNLKVTEITKDS--VSITWEPPLL 16754
Query: 244 WNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQG 301
S + + + R K++ + ++ I G + ++ A+ E+G G
Sbjct: 16755 DGGSKIK-NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIG 16811
Score = 30.0 bits (66), Expect = 3.4
Identities = 41/189 (21%), Positives = 74/189 (39%), Gaps = 16/189 (8%)
Query: 160 DFQEPCQYSQESQKF----SCQLAVPEG---DSSFYIVSMCVASSVGSKFSKTQTFQGCG 212
D +EP Y K +C L +P+ D+ Y ++ +++G+ SK G
Sbjct: 9854 DNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTIT--AVNNLGTA-SKEMRLNVLG 9910
Query: 213 ILQPDPPAN-ITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVK 271
+P PP I +V+ + LS W P S + + R KT+ +
Sbjct: 9911 --RPGPPVGPIKFESVSADQMTLS--WFPPKDDGGSKIT-NYVIEKREANRKTWVHVSSE 9965
Query: 272 DLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPM 331
+ I G +V ++ AQ ++G GE + PE ++ +P S
Sbjct: 9966 PKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTR 10025
Query: 332 QALTTNKDD 340
++T N ++
Sbjct: 10026 NSMTVNWEE 10034
Score = 30.0 bits (66), Expect = 3.4
Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 13/101 (12%)
Query: 216 PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTW-MVKDL 273
P PP ITV V RN +S++W P H S +++ + +A+ S+ ++ VK L
Sbjct: 16826 PQPPGKITVDDVTRNS--VSLSWTKPEHDGGSKI--IQYIVEMQAKHSEKWSECARVKSL 16881
Query: 274 QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTP 314
Q VI + G ++ ++ A E G+ + P ++ P
Sbjct: 16882 Q--AVITNLTQGEEYLFRVVAVNEKGRSD-----PRSLAVP 16915
Score = 29.3 bits (64), Expect = 5.8
Identities = 20/90 (22%), Positives = 44/90 (48%), Gaps = 3/90 (3%)
Query: 216 PDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH 275
P PP N+TV ++++ + VTW+ P S + + ++ R K+++T + +
Sbjct: 13482 PGPPVNVTVKEISKDSAY--VTWEPPIIDGGSPI-INYVVQKRDAERKSWSTVTTECSKT 13538
Query: 276 HCVIHDAWSGLRHVVQLRAQEEFGQGEWSE 305
+ + G + ++ A+ E+G G+ E
Sbjct: 13539 SFRVANLEEGKSYFFRVFAENEYGIGDPGE 13568
Score = 28.9 bits (63), Expect = 7.6
Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 7/64 (10%)
Query: 180 VPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQ 239
V D+ FY+V C + G KT + PDPP + V+ V+R+ +++TW
Sbjct: 24786 VERKDAGFYVV--CAKNRFGID-QKTVELDVADV--PDPPRGVKVSDVSRDS--VNLTWT 24838
Query: 240 DPHS 243
+P S
Sbjct: 24839 EPAS 24842
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 39.7 bits (91), Expect = 0.004
Identities = 35/120 (29%), Positives = 51/120 (42%), Gaps = 6/120 (5%)
Query: 216 PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAE-RSKTFTTWMVKDL 273
P PP N+T+T V N +S+TW+ P + + ELR + R T T +DL
Sbjct: 6819 PGPPLNVTITDV--NRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDL 6876
Query: 274 QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQA 333
+ D G + ++RAQ G G+ S +P E SPP S Q+
Sbjct: 6877 S--ATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQS 6934
Score = 31.6 bits (70), Expect = 1.2
Identities = 25/118 (21%), Positives = 50/118 (42%), Gaps = 8/118 (6%)
Query: 184 DSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHS 243
DS Y +++ +S S F + P PP N+ VT + ++ +S+TW+ P
Sbjct: 16635 DSGKYTLTLENSSGTKSAFVTVRVLD-----TPSPPVNLKVTEITKDS--VSITWEPPLL 16687
Query: 244 WNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQG 301
S + + + R K++ + ++ I G + ++ A+ E+G G
Sbjct: 16688 DGGSKIK-NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIG 16744
Score = 30.0 bits (66), Expect = 3.4
Identities = 41/189 (21%), Positives = 74/189 (39%), Gaps = 16/189 (8%)
Query: 160 DFQEPCQYSQESQKF----SCQLAVPEG---DSSFYIVSMCVASSVGSKFSKTQTFQGCG 212
D +EP Y K +C L +P+ D+ Y ++ +++G+ SK G
Sbjct: 9787 DNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTIT--AVNNLGTA-SKEMRLNVLG 9843
Query: 213 ILQPDPPAN-ITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVK 271
+P PP I +V+ + LS W P S + + R KT+ +
Sbjct: 9844 --RPGPPVGPIKFESVSADQMTLS--WFPPKDDGGSKIT-NYVIEKREANRKTWVHVSSE 9898
Query: 272 DLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPM 331
+ I G +V ++ AQ ++G GE + PE ++ +P S
Sbjct: 9899 PKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTR 9958
Query: 332 QALTTNKDD 340
++T N ++
Sbjct: 9959 NSMTVNWEE 9967
Score = 30.0 bits (66), Expect = 3.4
Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 13/101 (12%)
Query: 216 PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTW-MVKDL 273
P PP ITV V RN +S++W P H S +++ + +A+ S+ ++ VK L
Sbjct: 16759 PQPPGKITVDDVTRNS--VSLSWTKPEHDGGSKI--IQYIVEMQAKHSEKWSECARVKSL 16814
Query: 274 QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTP 314
Q VI + G ++ ++ A E G+ + P ++ P
Sbjct: 16815 Q--AVITNLTQGEEYLFRVVAVNEKGRSD-----PRSLAVP 16848
Score = 29.3 bits (64), Expect = 5.8
Identities = 20/90 (22%), Positives = 44/90 (48%), Gaps = 3/90 (3%)
Query: 216 PDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH 275
P PP N+TV ++++ + VTW+ P S + + ++ R K+++T + +
Sbjct: 13415 PGPPVNVTVKEISKDSAY--VTWEPPIIDGGSPI-INYVVQKRDAERKSWSTVTTECSKT 13471
Query: 276 HCVIHDAWSGLRHVVQLRAQEEFGQGEWSE 305
+ + G + ++ A+ E+G G+ E
Sbjct: 13472 SFRVANLEEGKSYFFRVFAENEYGIGDPGE 13501
Score = 28.9 bits (63), Expect = 7.6
Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 7/64 (10%)
Query: 180 VPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQ 239
V D+ FY+V C + G KT + PDPP + V+ V+R+ +++TW
Sbjct: 24719 VERKDAGFYVV--CAKNRFGID-QKTVELDVADV--PDPPRGVKVSDVSRDS--VNLTWT 24771
Query: 240 DPHS 243
+P S
Sbjct: 24772 EPAS 24775
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 39.7 bits (91), Expect = 0.004
Identities = 35/120 (29%), Positives = 51/120 (42%), Gaps = 6/120 (5%)
Query: 216 PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAE-RSKTFTTWMVKDL 273
P PP N+T+T V N +S+TW+ P + + ELR + R T T +DL
Sbjct: 6694 PGPPLNVTITDV--NRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDL 6751
Query: 274 QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQA 333
+ D G + ++RAQ G G+ S +P E SPP S Q+
Sbjct: 6752 S--ATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQS 6809
Score = 31.6 bits (70), Expect = 1.2
Identities = 25/118 (21%), Positives = 50/118 (42%), Gaps = 8/118 (6%)
Query: 184 DSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHS 243
DS Y +++ +S S F + P PP N+ VT + ++ +S+TW+ P
Sbjct: 16510 DSGKYTLTLENSSGTKSAFVTVRVLD-----TPSPPVNLKVTEITKDS--VSITWEPPLL 16562
Query: 244 WNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQG 301
S + + + R K++ + ++ I G + ++ A+ E+G G
Sbjct: 16563 DGGSKIK-NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIG 16619
Score = 30.0 bits (66), Expect = 3.4
Identities = 41/189 (21%), Positives = 74/189 (39%), Gaps = 16/189 (8%)
Query: 160 DFQEPCQYSQESQKF----SCQLAVPEG---DSSFYIVSMCVASSVGSKFSKTQTFQGCG 212
D +EP Y K +C L +P+ D+ Y ++ +++G+ SK G
Sbjct: 9662 DNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTIT--AVNNLGTA-SKEMRLNVLG 9718
Query: 213 ILQPDPPAN-ITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVK 271
+P PP I +V+ + LS W P S + + R KT+ +
Sbjct: 9719 --RPGPPVGPIKFESVSADQMTLS--WFPPKDDGGSKIT-NYVIEKREANRKTWVHVSSE 9773
Query: 272 DLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPM 331
+ I G +V ++ AQ ++G GE + PE ++ +P S
Sbjct: 9774 PKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTR 9833
Query: 332 QALTTNKDD 340
++T N ++
Sbjct: 9834 NSMTVNWEE 9842
Score = 30.0 bits (66), Expect = 3.4
Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 13/101 (12%)
Query: 216 PDPPANITVTAVARNPRWLSVTWQDP-HSWNSSFYRLRFELRYRAERSKTFTTW-MVKDL 273
P PP ITV V RN +S++W P H S +++ + +A+ S+ ++ VK L
Sbjct: 16634 PQPPGKITVDDVTRNS--VSLSWTKPEHDGGSKI--IQYIVEMQAKHSEKWSECARVKSL 16689
Query: 274 QHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTP 314
Q VI + G ++ ++ A E G+ + P ++ P
Sbjct: 16690 Q--AVITNLTQGEEYLFRVVAVNEKGRSD-----PRSLAVP 16723
Score = 29.3 bits (64), Expect = 5.8
Identities = 20/90 (22%), Positives = 44/90 (48%), Gaps = 3/90 (3%)
Query: 216 PDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQH 275
P PP N+TV ++++ + VTW+ P S + + ++ R K+++T + +
Sbjct: 13290 PGPPVNVTVKEISKDSAY--VTWEPPIIDGGSPI-INYVVQKRDAERKSWSTVTTECSKT 13346
Query: 276 HCVIHDAWSGLRHVVQLRAQEEFGQGEWSE 305
+ + G + ++ A+ E+G G+ E
Sbjct: 13347 SFRVANLEEGKSYFFRVFAENEYGIGDPGE 13376
Score = 28.9 bits (63), Expect = 7.6
Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 7/64 (10%)
Query: 180 VPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQ 239
V D+ FY+V C + G KT + PDPP + V+ V+R+ +++TW
Sbjct: 24594 VERKDAGFYVV--CAKNRFGID-QKTVELDVADV--PDPPRGVKVSDVSRDS--VNLTWT 24646
Query: 240 DPHS 243
+P S
Sbjct: 24647 EPAS 24650
>gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Homo
sapiens]
Length = 602
Score = 38.5 bits (88), Expect = 0.010
Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 12/124 (9%)
Query: 40 GDSVTLTCPGVEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSC-- 96
G + L C + + AT+ WVL+ + + SHP W L LR V+ DSG Y+C
Sbjct: 280 GQFLRLLC-AADSQPPATLSWVLQDRVLSSSHP--WGPRTLGLELRGVRAGDSGRYTCRA 336
Query: 97 -YRAGRPAGTVHLLVDVPPE--EPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKF 153
R G + L V PPE +S ++ L N+ S P L +++ LV
Sbjct: 337 ENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENL---GNGTSLPVLEGQSLRLVCVT 393
Query: 154 QNSP 157
+SP
Sbjct: 394 HSSP 397
>gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Homo
sapiens]
Length = 698
Score = 38.5 bits (88), Expect = 0.010
Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 12/124 (9%)
Query: 40 GDSVTLTCPGVEPEDNATVHWVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSC-- 96
G + L C + + AT+ WVL+ + + SHP W L LR V+ DSG Y+C
Sbjct: 280 GQFLRLLC-AADSQPPATLSWVLQDRVLSSSHP--WGPRTLGLELRGVRAGDSGRYTCRA 336
Query: 97 -YRAGRPAGTVHLLVDVPPE--EPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKF 153
R G + L V PPE +S ++ L N+ S P L +++ LV
Sbjct: 337 ENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENL---GNGTSLPVLEGQSLRLVCVT 393
Query: 154 QNSP 157
+SP
Sbjct: 394 HSSP 397
>gi|169214048 PREDICTED: hypothetical protein [Homo sapiens]
Length = 881
Score = 37.4 bits (85), Expect = 0.021
Identities = 30/87 (34%), Positives = 40/87 (45%), Gaps = 12/87 (13%)
Query: 40 GDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRA 99
G +VTL C A + W L PA + P+ G RLLL +V +G Y+C A
Sbjct: 421 GSNVTLRCAAAS-RPPADITWSLADPAEAAVPA-----GSRLLLPAVGPGHAGTYACLAA 474
Query: 100 G-----RPAGTVHLLV-DVPPEEPQLS 120
R ++L V D+PP PQ S
Sbjct: 475 NPRTGRRRRSLLNLTVADLPPGAPQCS 501
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.131 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,630,774
Number of Sequences: 37866
Number of extensions: 822275
Number of successful extensions: 2887
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 2569
Number of HSP's gapped (non-prelim): 399
length of query: 365
length of database: 18,247,518
effective HSP length: 104
effective length of query: 261
effective length of database: 14,309,454
effective search space: 3734767494
effective search space used: 3734767494
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.