Search of human proteins with 30795229

Search of human proteins with 30795229

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo
sapiens]
         (526 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]    1079   0.0  
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is...   741   0.0  
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ...   730   0.0  
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs...   685   0.0  
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs...   685   0.0  
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]                 652   0.0  
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]              617   e-176
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       615   e-176
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]      608   e-174
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   587   e-168
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   587   e-168
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   582   e-166
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   582   e-166
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi...   582   e-166
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]      537   e-152
gi|4503787 fyn-related kinase [Homo sapiens]                          473   e-133
gi|18250298 src-related kinase lacking C-terminal regulatory tyr...   367   e-101
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   362   e-100
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   358   9e-99
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             357   1e-98
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             355   7e-98
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               355   7e-98
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             355   7e-98
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             355   7e-98
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]              349   3e-96
gi|148596974 TXK tyrosine kinase [Homo sapiens]                       327   2e-89
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               325   5e-89
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]   323   3e-88
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                309   5e-84
gi|187475373 c-src tyrosine kinase [Homo sapiens]                     285   7e-77

>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score = 1079 bits (2790), Expect = 0.0
 Identities = 526/526 (100%), Positives = 526/526 (100%)

Query: 1   MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK 60
           MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
Sbjct: 1   MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK 60

Query: 61  PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL 120
           PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
Sbjct: 61  PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL 120

Query: 121 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY 180
           ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
Sbjct: 121 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY 180

Query: 181 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP 240
           SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
Sbjct: 181 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP 240

Query: 241 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE 300
           CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
Sbjct: 241 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE 300

Query: 301 AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID 360
           AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
Sbjct: 301 AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID 360

Query: 361 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP 420
           FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
Sbjct: 361 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP 420

Query: 421 IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE 480
           IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
Sbjct: 421 IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE 480

Query: 481 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 526
           NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
Sbjct: 481 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 526


>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform A [Homo sapiens]
          Length = 512

 Score =  741 bits (1913), Expect = 0.0
 Identities = 364/516 (70%), Positives = 429/516 (83%), Gaps = 15/516 (2%)

Query: 22  MGCMKSKFLQVGGNTFS------KTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIR- 74
           MGC+KSK    G ++ S      KT+   +    +YV DPTS  +  P   +   PG R 
Sbjct: 1   MGCIKSK----GKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRF 56

Query: 75  ---EAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSN 131
              +   +  IVVALY Y+ IH +DLSF+KG++M VLEE GEWWKA+SL T+KEG+IPSN
Sbjct: 57  QTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSN 116

Query: 132 YVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQ 191
           YVA++++LETEEWFFK I+RKDAERQLLAPGN  G+F+IR+SET KGS+SLSVRD+DP  
Sbjct: 117 YVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVH 176

Query: 192 GDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWE 251
           GD +KHYKIR+LDNGG+YISPR TF  + +++ HY+K  DGLC++L   C+S KPQKPW+
Sbjct: 177 GDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD 236

Query: 252 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 311
           KDAWEIPRES+KL K+LGAGQFGEVWM  YN  TKVAVKT+KPG+MSV+AFL EAN+MKT
Sbjct: 237 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKT 296

Query: 312 LQHDKLVKLHAVVTK-EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 370
           LQHDKLV+L+AVVT+ EPIYIITE+MAKGSLLDFLKSDEG K  LPKLIDFSAQIAEGMA
Sbjct: 297 LQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMA 356

Query: 371 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 430
           +IE++NYIHRDLRAAN+LVS SL+CKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN
Sbjct: 357 YIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 416

Query: 431 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIM 490
           FG FTIKSDVWSFGILL EIVTYG+IPYPG +N +V+ AL +GYRMPR ENCP+ELY+IM
Sbjct: 417 FGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIM 476

Query: 491 MRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 526
             CWK + EERPTF+Y+QSVLDDFYTATE QYQQQP
Sbjct: 477 KMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 512


>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform B [Homo sapiens]
          Length = 491

 Score =  730 bits (1884), Expect = 0.0
 Identities = 360/506 (71%), Positives = 419/506 (82%), Gaps = 16/506 (3%)

Query: 22  MGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDI 81
           MGC+KSK    G ++ S              P P S + PG       T    E G    
Sbjct: 1   MGCIKSK----GKDSLSDDGVDLKTQ-----PVPESQLLPG---QRFQTKDPEEQGD--- 45

Query: 82  IVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLET 141
           IVVALY Y+ IH +DLSF+KG++M VLEE GEWWKA+SL T+KEG+IPSNYVA++++LET
Sbjct: 46  IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLET 105

Query: 142 EEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIR 201
           EEWFFK I+RKDAERQLLAPGN  G+F+IR+SET KGS+SLSVRD+DP  GD +KHYKIR
Sbjct: 106 EEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIR 165

Query: 202 TLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRES 261
           +LDNGG+YISPR TF  + +++ HY+K  DGLC++L   C+S KPQKPW+KDAWEIPRES
Sbjct: 166 SLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRES 225

Query: 262 LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLH 321
           +KL K+LGAGQFGEVWM  YN  TKVAVKT+KPG+MSV+AFL EAN+MKTLQHDKLV+L+
Sbjct: 226 IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY 285

Query: 322 AVVTK-EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR 380
           AVVT+ EPIYIITE+MAKGSLLDFLKSDEG K  LPKLIDFSAQIAEGMA+IE++NYIHR
Sbjct: 286 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR 345

Query: 381 DLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV 440
           DLRAAN+LVS SL+CKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG FTIKSDV
Sbjct: 346 DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV 405

Query: 441 WSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEE 500
           WSFGILL EIVTYG+IPYPG +N +V+ AL +GYRMPR ENCP+ELY+IM  CWK + EE
Sbjct: 406 WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE 465

Query: 501 RPTFEYIQSVLDDFYTATESQYQQQP 526
           RPTF+Y+QSVLDDFYTATE QYQQQP
Sbjct: 466 RPTFDYLQSVLDDFYTATEGQYQQQP 491


>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  685 bits (1768), Expect = 0.0
 Identities = 324/448 (72%), Positives = 384/448 (85%)

Query: 79  EDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDS 138
           +D +V+AL+ YE  H  DL F+KG+Q+ +LE+SGEWWKA+SL T +EG+IP N+VA+ +S
Sbjct: 62  QDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANS 121

Query: 139 LETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHY 198
           LE E WFFK +SRKDAERQLLAPGN  GSF+IR+SE+T GS+SLSVRD+D  QG+ VKHY
Sbjct: 122 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 181

Query: 199 KIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIP 258
           KIR LDNGGFYISPR TF  L ELV HY   +DGLC +LS PC + KPQKPW +D WE+P
Sbjct: 182 KIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVP 241

Query: 259 RESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLV 318
           RE+LKL ++LGAGQFGEVWM  YN HTKVAVK++K GSMS +AFLAEAN+MK LQH +LV
Sbjct: 242 RETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLV 301

Query: 319 KLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYI 378
           +L+AVVT+EPIYIITE+M  GSL+DFLK+  G K  + KL+D +AQIAEGMAFIE+RNYI
Sbjct: 302 RLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYI 361

Query: 379 HRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKS 438
           HRDLRAANILVS +L CKIADFGLAR+IEDNEYTAREGAKFPIKWTAPEAIN+G+FTIKS
Sbjct: 362 HRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKS 421

Query: 439 DVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRP 498
           DVWSFGILL EIVT+GRIPYPGM+NPEVI+ LERGYRM RP+NCPEELY +M  CWK RP
Sbjct: 422 DVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERP 481

Query: 499 EERPTFEYIQSVLDDFYTATESQYQQQP 526
           E+RPTF+Y++SVL+DF+TATE QYQ QP
Sbjct: 482 EDRPTFDYLRSVLEDFFTATEGQYQPQP 509


>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  685 bits (1768), Expect = 0.0
 Identities = 324/448 (72%), Positives = 384/448 (85%)

Query: 79  EDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDS 138
           +D +V+AL+ YE  H  DL F+KG+Q+ +LE+SGEWWKA+SL T +EG+IP N+VA+ +S
Sbjct: 62  QDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANS 121

Query: 139 LETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHY 198
           LE E WFFK +SRKDAERQLLAPGN  GSF+IR+SE+T GS+SLSVRD+D  QG+ VKHY
Sbjct: 122 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 181

Query: 199 KIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIP 258
           KIR LDNGGFYISPR TF  L ELV HY   +DGLC +LS PC + KPQKPW +D WE+P
Sbjct: 182 KIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVP 241

Query: 259 RESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLV 318
           RE+LKL ++LGAGQFGEVWM  YN HTKVAVK++K GSMS +AFLAEAN+MK LQH +LV
Sbjct: 242 RETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLV 301

Query: 319 KLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYI 378
           +L+AVVT+EPIYIITE+M  GSL+DFLK+  G K  + KL+D +AQIAEGMAFIE+RNYI
Sbjct: 302 RLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYI 361

Query: 379 HRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKS 438
           HRDLRAANILVS +L CKIADFGLAR+IEDNEYTAREGAKFPIKWTAPEAIN+G+FTIKS
Sbjct: 362 HRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKS 421

Query: 439 DVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRP 498
           DVWSFGILL EIVT+GRIPYPGM+NPEVI+ LERGYRM RP+NCPEELY +M  CWK RP
Sbjct: 422 DVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERP 481

Query: 499 EERPTFEYIQSVLDDFYTATESQYQQQP 526
           E+RPTF+Y++SVL+DF+TATE QYQ QP
Sbjct: 482 EDRPTFDYLRSVLEDFFTATEGQYQPQP 509


>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
          Length = 505

 Score =  652 bits (1681), Expect = 0.0
 Identities = 312/463 (67%), Positives = 381/463 (82%), Gaps = 3/463 (0%)

Query: 65  SHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRK 124
           +H +  P       +   VVALYDY A++  DL   KG+++ VL+ +G+WW ARSL T +
Sbjct: 45  NHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGR 104

Query: 125 EGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSV 184
           EGY+PSN+VARV+SLE E WFF+   RK+AERQLLAP N  GSF+IR+SET KG++SLSV
Sbjct: 105 EGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSV 164

Query: 185 RDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSS 244
           +D    QG+ +KHYKIR LD GG+YISPR TF +LQ LV HY K  DGLCQ+L++PC+  
Sbjct: 165 KDVTT-QGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRP 223

Query: 245 KPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLA 304
            PQ PW +D WEIPR+SL+L +KLG+GQFGEVWM  Y  + KVA+KT+K G+MS EAFL 
Sbjct: 224 APQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLG 283

Query: 305 EANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQ 364
           EANVMK LQH++LV+L+AVVTKEPIYI+TE+MA+G LLDFLK+DEGS+  LP+LID SAQ
Sbjct: 284 EANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQ 343

Query: 365 IAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWT 424
           IAEGMA+IE+ N IHRDLRAANILVS +L CKIADFGLAR+I D+EYTA+EGAKFPIKWT
Sbjct: 344 IAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWT 402

Query: 425 APEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPE 484
           APEAI+FG FTIK+DVWSFG+LLME+VTYGR+PYPGMSNPEVIR LERGYRMPRP+ CP 
Sbjct: 403 APEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPP 462

Query: 485 ELY-NIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 526
           ELY  ++  CW++RPEERPTFE++QSVL+DFYTATE QY+ QP
Sbjct: 463 ELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP 505


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score =  617 bits (1590), Expect = e-176
 Identities = 304/466 (65%), Positives = 367/466 (78%), Gaps = 4/466 (0%)

Query: 62  GPNSHNSNTPGIREAGSED--IIVVALYDYEAIHHEDLSFQKGDQMVVLEES-GEWWKAR 118
           G +S  S  P    AG      I VALYDYEA   EDLSF+KG++  ++  + G+WW+AR
Sbjct: 73  GASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEAR 132

Query: 119 SLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKG 178
           S+AT K GYIPSNYVA  DS++ EEW+F  + RKDAER LL PGN  G F++R+SETTKG
Sbjct: 133 SIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKG 192

Query: 179 SYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLS 238
           +YSLS+RD+D  +GD VKHYKIR LDNGG+YI+ R+ F TLQ+LV HY +  DGLC KL+
Sbjct: 193 AYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLT 252

Query: 239 VPCMSSKPQ-KPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSM 297
             C + KPQ +   KDAWEIPRESL+LE KLG G FGEVWM T+N  TKVA+KT+KPG+M
Sbjct: 253 TVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTM 312

Query: 298 SVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPK 357
             EAFL EA +MK L+HDKLV L+AVV++EPIYI+TEFM+KGSLLDFLK  +G    LP+
Sbjct: 313 MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQ 372

Query: 358 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGA 417
           L+D +AQIA+GMA+IE+ NYIHRDLRAANILV  +LVCKIADFGLAR+IEDNEYTAR+GA
Sbjct: 373 LVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGA 432

Query: 418 KFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMP 477
           KFPIKWTAPEA  +G FTIKSDVWSFGIL  E+VT GR+PYPGM N EV+  +ERGYRMP
Sbjct: 433 KFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMP 492

Query: 478 RPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQ 523
            P+ CPE L+ +M  CWK  P+ERPTFEYIQS L+D++TATE QYQ
Sbjct: 493 CPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQ 538


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  615 bits (1585), Expect = e-176
 Identities = 301/472 (63%), Positives = 373/472 (79%), Gaps = 7/472 (1%)

Query: 58  TIKPGPNSHNSNTPGIREAGSEDI-IVVALYDYEAIHHEDLSFQKGDQMVVLEES-GEWW 115
           T+  G NS +S+T  +R  G   + + VALYDYEA   +DLSF KG++  +L  S G+WW
Sbjct: 62  TVFGGVNS-SSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120

Query: 116 KARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSET 175
           +ARSL T + GYIPSNYVA VDS++ EEW+F  + RKDAERQLL+ GN  G+F+IR+SET
Sbjct: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180

Query: 176 TKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQ 235
           TKG+YSLS+RD+D  +GD VKHYKIR LDNGG+YI+ R+ F TLQ+LV HY +   GLC 
Sbjct: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC 240

Query: 236 KLSVPCMSSKPQ----KPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKT 291
           +L VPC    P+        KD WEIPRESL+L K+LG GQFGEVWM T+N +TKVA+KT
Sbjct: 241 RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT 300

Query: 292 MKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGS 351
           +KPG+MS E+FL EA +MK L+HDKLV+L+AVV++EPIYI+TE+M KGSLLDFLK  EG 
Sbjct: 301 LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR 360

Query: 352 KQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEY 411
              LP L+D +AQ+A GMA+IE+ NYIHRDLR+ANILV   L+CKIADFGLAR+IEDNEY
Sbjct: 361 ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY 420

Query: 412 TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALE 471
           TAR+GAKFPIKWTAPEA  +G FTIKSDVWSFGILL E+VT GR+PYPGM+N EV+  +E
Sbjct: 421 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE 480

Query: 472 RGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQ 523
           RGYRMP P++CP  L+ +M+ CWK  PEERPTFEY+QS L+D++TATE QYQ
Sbjct: 481 RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQ 532


>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score =  608 bits (1568), Expect = e-174
 Identities = 299/469 (63%), Positives = 370/469 (78%), Gaps = 4/469 (0%)

Query: 58  TIKPGPNSHNSNTPGIREAGSEDI-IVVALYDYEAIHHEDLSFQKGDQMVVLEES-GEWW 115
           T+  G NS +S+T  +R  G   + + VALYDYEA   +DLSF KG++  +L  S G+WW
Sbjct: 62  TVFGGVNS-SSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120

Query: 116 KARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSET 175
           +ARSL T + GYIPSNYVA VDS++ EEW+F  + RKDAERQLL+ GN  G+F+IR+SET
Sbjct: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180

Query: 176 TKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQ 235
           TKG+YSLS+RD+D  +GD VKHYKIR LDNGG+YI+ R+ F TLQ+LV HY +  DGLC 
Sbjct: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCF 240

Query: 236 KLSVPCMSSKPQKPW-EKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKP 294
            L+V   S  PQ     KDAWE+ R SL LEKKLG G F EVW+ T+N +TKVA+KT+KP
Sbjct: 241 NLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKP 300

Query: 295 GSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQP 354
           G+MS E+FL EA +MK L+HDKLV+L+AVV++EPIYI+TE+M KGSLLDFLK  EG    
Sbjct: 301 GTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALK 360

Query: 355 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAR 414
           LP L+D +AQ+A GMA+IE+ NYIHRDLR+ANILV   L+CKIADFGLAR+IEDNEYTAR
Sbjct: 361 LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTAR 420

Query: 415 EGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY 474
           +GAKFPIKWTAPEA  +G FTIKSDVWSFGILL E+VT GR+PYPGM+N EV+  +ERGY
Sbjct: 421 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY 480

Query: 475 RMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQ 523
           RMP P++CP  L+ +M+ CWK  PEERPTFEY+QS L+D++TATE QYQ
Sbjct: 481 RMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQ 529


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  587 bits (1513), Expect = e-168
 Identities = 291/504 (57%), Positives = 378/504 (75%), Gaps = 13/504 (2%)

Query: 33  GGNTFSKTETSASPHCPVYVPDPTSTIKP---------GPNSHNSNTPGIREAGSEDIIV 83
           GG  F  ++T + P        P++   P         G NS ++ T   R       + 
Sbjct: 28  GGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVT 87

Query: 84  --VALYDYEAIHHEDLSFQKGDQMVVLEES-GEWWKARSLATRKEGYIPSNYVARVDSLE 140
             VALYDYE+    DLSF+KG+++ ++  + G+WW A SL+T + GYIPSNYVA  DS++
Sbjct: 88  TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQ 147

Query: 141 TEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKI 200
            EEW+F  I+R+++ER LL   N  G+F++R+SETTKG+Y LSV D+D  +G  VKHYKI
Sbjct: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKI 207

Query: 201 RTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQ-KPWEKDAWEIPR 259
           R LD+GGFYI+ R+ F++LQ+LV +Y K  DGLC +L+  C +SKPQ +   KDAWEIPR
Sbjct: 208 RKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPR 267

Query: 260 ESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVK 319
           ESL+LE KLG G FGEVWM T+N  T+VA+KT+KPG+MS EAFL EA VMK L+H+KLV+
Sbjct: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQ 327

Query: 320 LHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIH 379
           L+AVV++EPIYI+TE+M+KGSLLDFLK + G    LP+L+D +AQIA GMA++E+ NY+H
Sbjct: 328 LYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387

Query: 380 RDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSD 439
           RDLRAANILV  +LVCK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA  +G FTIKSD
Sbjct: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 447

Query: 440 VWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPE 499
           VWSFGILL E+ T GR+PYPGM N EV+  +ERGYRMP P  CPE L+++M +CW+  PE
Sbjct: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPE 507

Query: 500 ERPTFEYIQSVLDDFYTATESQYQ 523
           ERPTFEY+Q+ L+D++T+TE QYQ
Sbjct: 508 ERPTFEYLQAFLEDYFTSTEPQYQ 531


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  587 bits (1513), Expect = e-168
 Identities = 291/504 (57%), Positives = 378/504 (75%), Gaps = 13/504 (2%)

Query: 33  GGNTFSKTETSASPHCPVYVPDPTSTIKP---------GPNSHNSNTPGIREAGSEDIIV 83
           GG  F  ++T + P        P++   P         G NS ++ T   R       + 
Sbjct: 28  GGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVT 87

Query: 84  --VALYDYEAIHHEDLSFQKGDQMVVLEES-GEWWKARSLATRKEGYIPSNYVARVDSLE 140
             VALYDYE+    DLSF+KG+++ ++  + G+WW A SL+T + GYIPSNYVA  DS++
Sbjct: 88  TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQ 147

Query: 141 TEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKI 200
            EEW+F  I+R+++ER LL   N  G+F++R+SETTKG+Y LSV D+D  +G  VKHYKI
Sbjct: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKI 207

Query: 201 RTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQ-KPWEKDAWEIPR 259
           R LD+GGFYI+ R+ F++LQ+LV +Y K  DGLC +L+  C +SKPQ +   KDAWEIPR
Sbjct: 208 RKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPR 267

Query: 260 ESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVK 319
           ESL+LE KLG G FGEVWM T+N  T+VA+KT+KPG+MS EAFL EA VMK L+H+KLV+
Sbjct: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQ 327

Query: 320 LHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIH 379
           L+AVV++EPIYI+TE+M+KGSLLDFLK + G    LP+L+D +AQIA GMA++E+ NY+H
Sbjct: 328 LYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387

Query: 380 RDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSD 439
           RDLRAANILV  +LVCK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA  +G FTIKSD
Sbjct: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 447

Query: 440 VWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPE 499
           VWSFGILL E+ T GR+PYPGM N EV+  +ERGYRMP P  CPE L+++M +CW+  PE
Sbjct: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPE 507

Query: 500 ERPTFEYIQSVLDDFYTATESQYQ 523
           ERPTFEY+Q+ L+D++T+TE QYQ
Sbjct: 508 ERPTFEYLQAFLEDYFTSTEPQYQ 531


>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  582 bits (1499), Expect = e-166
 Identities = 291/491 (59%), Positives = 367/491 (74%), Gaps = 18/491 (3%)

Query: 51  YVPDPT-----STIKPGPNSHNSNT----PGIREAGSED-------IIVVALYDYEAIHH 94
           Y PDPT     S+    PN  N ++    PG  ++G+          + +ALYDYEA   
Sbjct: 34  YGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTE 93

Query: 95  EDLSFQKGDQMVVLEES-GEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKD 153
           +DL+F KG++  +L  + G+WW+ARSL++ K G IPSNYVA VDS++ EEW+F  I RKD
Sbjct: 94  DDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKD 153

Query: 154 AERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPR 213
           AERQLL+PGN  G+F+IR+SETTKG+YSLS+RD+D  +GD VKHYKIR LD GG+YI+ R
Sbjct: 154 AERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTR 213

Query: 214 STFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQK-PWEKDAWEIPRESLKLEKKLGAGQ 272
             F+++QELV HY + NDGLC  L  PC   KPQ     KDAWEI R S+ LE++LG G 
Sbjct: 214 VQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGC 273

Query: 273 FGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYII 332
           FG+VW+ T+N  TKVAVKT+KPG+MS +AFL EA VMK L+HDKLV+L+AVV++EPIYI+
Sbjct: 274 FGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIV 333

Query: 333 TEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSAS 392
           TEFM  GSLLDFLK+ EG    LP+L+D +AQ+AEGMA++E+ NYIHRDLRAANILV   
Sbjct: 334 TEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGER 393

Query: 393 LVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVT 452
           L CKIADFGLAR+I+D+EY   +G+KFPIKWTAPEA  FG FTIKSDVWSFGILL E++T
Sbjct: 394 LACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELIT 453

Query: 453 YGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLD 512
            GRIPYPGM+  EV+  +E+GY MP P  CP  LY  M + W+  PEERPTFEY+QS L+
Sbjct: 454 KGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513

Query: 513 DFYTATESQYQ 523
           D++T+ E QYQ
Sbjct: 514 DYFTSAEPQYQ 524


>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  582 bits (1499), Expect = e-166
 Identities = 291/491 (59%), Positives = 367/491 (74%), Gaps = 18/491 (3%)

Query: 51  YVPDPT-----STIKPGPNSHNSNT----PGIREAGSED-------IIVVALYDYEAIHH 94
           Y PDPT     S+    PN  N ++    PG  ++G+          + +ALYDYEA   
Sbjct: 34  YGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTE 93

Query: 95  EDLSFQKGDQMVVLEES-GEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKD 153
           +DL+F KG++  +L  + G+WW+ARSL++ K G IPSNYVA VDS++ EEW+F  I RKD
Sbjct: 94  DDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKD 153

Query: 154 AERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPR 213
           AERQLL+PGN  G+F+IR+SETTKG+YSLS+RD+D  +GD VKHYKIR LD GG+YI+ R
Sbjct: 154 AERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTR 213

Query: 214 STFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQK-PWEKDAWEIPRESLKLEKKLGAGQ 272
             F+++QELV HY + NDGLC  L  PC   KPQ     KDAWEI R S+ LE++LG G 
Sbjct: 214 VQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGC 273

Query: 273 FGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYII 332
           FG+VW+ T+N  TKVAVKT+KPG+MS +AFL EA VMK L+HDKLV+L+AVV++EPIYI+
Sbjct: 274 FGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIV 333

Query: 333 TEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSAS 392
           TEFM  GSLLDFLK+ EG    LP+L+D +AQ+AEGMA++E+ NYIHRDLRAANILV   
Sbjct: 334 TEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGER 393

Query: 393 LVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVT 452
           L CKIADFGLAR+I+D+EY   +G+KFPIKWTAPEA  FG FTIKSDVWSFGILL E++T
Sbjct: 394 LACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELIT 453

Query: 453 YGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLD 512
            GRIPYPGM+  EV+  +E+GY MP P  CP  LY  M + W+  PEERPTFEY+QS L+
Sbjct: 454 KGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513

Query: 513 DFYTATESQYQ 523
           D++T+ E QYQ
Sbjct: 514 DYFTSAEPQYQ 524


>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  582 bits (1499), Expect = e-166
 Identities = 291/491 (59%), Positives = 367/491 (74%), Gaps = 18/491 (3%)

Query: 51  YVPDPT-----STIKPGPNSHNSNT----PGIREAGSED-------IIVVALYDYEAIHH 94
           Y PDPT     S+    PN  N ++    PG  ++G+          + +ALYDYEA   
Sbjct: 34  YGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTE 93

Query: 95  EDLSFQKGDQMVVLEES-GEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKD 153
           +DL+F KG++  +L  + G+WW+ARSL++ K G IPSNYVA VDS++ EEW+F  I RKD
Sbjct: 94  DDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKD 153

Query: 154 AERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPR 213
           AERQLL+PGN  G+F+IR+SETTKG+YSLS+RD+D  +GD VKHYKIR LD GG+YI+ R
Sbjct: 154 AERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTR 213

Query: 214 STFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQK-PWEKDAWEIPRESLKLEKKLGAGQ 272
             F+++QELV HY + NDGLC  L  PC   KPQ     KDAWEI R S+ LE++LG G 
Sbjct: 214 VQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGC 273

Query: 273 FGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYII 332
           FG+VW+ T+N  TKVAVKT+KPG+MS +AFL EA VMK L+HDKLV+L+AVV++EPIYI+
Sbjct: 274 FGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIV 333

Query: 333 TEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSAS 392
           TEFM  GSLLDFLK+ EG    LP+L+D +AQ+AEGMA++E+ NYIHRDLRAANILV   
Sbjct: 334 TEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGER 393

Query: 393 LVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVT 452
           L CKIADFGLAR+I+D+EY   +G+KFPIKWTAPEA  FG FTIKSDVWSFGILL E++T
Sbjct: 394 LACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELIT 453

Query: 453 YGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLD 512
            GRIPYPGM+  EV+  +E+GY MP P  CP  LY  M + W+  PEERPTFEY+QS L+
Sbjct: 454 KGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513

Query: 513 DFYTATESQYQ 523
           D++T+ E QYQ
Sbjct: 514 DYFTSAEPQYQ 524


>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
          Length = 482

 Score =  537 bits (1383), Expect = e-152
 Identities = 271/468 (57%), Positives = 338/468 (72%), Gaps = 54/468 (11%)

Query: 58  TIKPGPNSHNSNTPGIREAGSEDI-IVVALYDYEAIHHEDLSFQKGDQMVVLEES-GEWW 115
           T+  G NS +S+T  +R  G   + + VALYDYEA   +DLSF KG++  +L  S G+WW
Sbjct: 62  TVFGGVNS-SSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW 120

Query: 116 KARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSET 175
           +ARSL T + GYIPSNYVA VDS++ EEW+F  + RKDAERQLL+ GN  G+F+IR+SET
Sbjct: 121 EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET 180

Query: 176 TKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQ 235
           TKG+YSLS+RD+D  +GD VKHYKIR LDNGG+YI+ R+ F TLQ+LV HY         
Sbjct: 181 TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS-------- 232

Query: 236 KLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPG 295
                                                       T+N +TKVA+KT+KPG
Sbjct: 233 -------------------------------------------GTWNGNTKVAIKTLKPG 249

Query: 296 SMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPL 355
           +MS E+FL EA +MK L+HDKLV+L+AVV++EPIYI+TE+M KGSLLDFLK  EG    L
Sbjct: 250 TMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKL 309

Query: 356 PKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTARE 415
           P L+D +AQ+A GMA+IE+ NYIHRDLR+ANILV   L+CKIADFGLAR+IEDNEYTAR+
Sbjct: 310 PNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQ 369

Query: 416 GAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYR 475
           GAKFPIKWTAPEA  +G FTIKSDVWSFGILL E+VT GR+PYPGM+N EV+  +ERGYR
Sbjct: 370 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYR 429

Query: 476 MPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQ 523
           MP P++CP  L+ +M+ CWK  PEERPTFEY+QS L+D++TATE QYQ
Sbjct: 430 MPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQ 477


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  473 bits (1217), Expect = e-133
 Identities = 245/456 (53%), Positives = 316/456 (69%), Gaps = 23/456 (5%)

Query: 84  VALYDYEAIHHEDLSFQKGDQMVVLEESGE-WWKARSLATRKEG-------YIPSNYVAR 135
           VAL+DY+A   EDLSF+ GD++ VL+   E WW AR L  R++G       YIPSNYVA 
Sbjct: 48  VALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAE 107

Query: 136 VDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTV 195
             SL+ E WFF  I R DAE+QLL   N  GSF+IR+SE+ KG +SLSV D     G  V
Sbjct: 108 DRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAVV 162

Query: 196 KHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEK--- 252
           KHY+I+ LD GGF+++ R  FSTL E V HY K +DGLC KL  PC+  +   P++    
Sbjct: 163 KHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYK 222

Query: 253 --DAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMK 310
             D WEI R S++L K+LG+GQFGEVW   +N  T VAVKT+KPGSM    FL EA +MK
Sbjct: 223 TVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMK 282

Query: 311 TLQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGM 369
            L+H KL++L+AV T E PIYIITE M  GSL ++L++D GSK  L + +D +AQ+A GM
Sbjct: 283 NLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGM 342

Query: 370 AFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIE-DNE--YTAREGAKFPIKWTAP 426
           A++E RNYIHRDL A N+LV    + K+ADFGLARV + DNE  Y +R   K P+KWTAP
Sbjct: 343 AYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAP 402

Query: 427 EAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEEL 486
           EAI    F+IKSDVWSFGILL EI+TYG++PY GM+  +VI+ L + YR+P+P NCP++ 
Sbjct: 403 EAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQF 462

Query: 487 YNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQY 522
           YNIM+ CW   P+ERPTFE ++  L+D++  T+S Y
Sbjct: 463 YNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSY 497


>gi|18250298 src-related kinase lacking C-terminal regulatory
           tyrosine and N-terminal myristylation sites [Homo
           sapiens]
          Length = 488

 Score =  367 bits (941), Expect = e-101
 Identities = 191/458 (41%), Positives = 282/458 (61%), Gaps = 17/458 (3%)

Query: 63  PNSHNSNTPGIREAGSEDI-----IVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKA 117
           P S + NT  +    +E       + +ALYD+ A    +LS ++GD++  LEE G +  A
Sbjct: 31  PGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFA 90

Query: 118 RSLATRKE-GYIPSNYVARV--DSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSE 174
           R L+ +   G +P  +VA+   ++L  + W+F G+SR  A++ LL+P N  G+F+IR SE
Sbjct: 91  RRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSE 150

Query: 175 TTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLC 234
           ++ G YSLSVR         V HY++    +G  Y+     F  L+EL+ +YK     + 
Sbjct: 151 SSLGGYSLSVRAQAK-----VCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQ 205

Query: 235 QKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKP 294
             L  PCM   PQK   +D WE P     L +KLG G FGEVW   +     VA+K +K 
Sbjct: 206 NPLLQPCM---PQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKS 262

Query: 295 GSMSVEAFLAEANVMKTLQHDKLVKLHAVVTK-EPIYIITEFMAKGSLLDFLKSDEGSKQ 353
            +M +     E   +K L+H++L++LHAV +  EP+YI+TE M KG+L  FL + EG   
Sbjct: 263 ANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRAL 322

Query: 354 PLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTA 413
            LP L+ F+ Q+AEGM+++E++  +HRDL A N+LV   L CK+ADFGLAR+++D+ Y+ 
Sbjct: 323 RLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSP 382

Query: 414 REGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERG 473
              +K P+KWTAPEA N+  F+ KSDVWSFG+LL E+ TYG+ PY GM+N E ++ + RG
Sbjct: 383 SSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRG 442

Query: 474 YRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVL 511
           YR+PRP  CP E+Y +M+ CW++ PEERP+F  ++  L
Sbjct: 443 YRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  362 bits (928), Expect = e-100
 Identities = 211/532 (39%), Positives = 309/532 (58%), Gaps = 42/532 (7%)

Query: 8   EDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHN 67
           + PG    ++R P +  +   F++  G    ++     PHC V+V          P + +
Sbjct: 3   QQPGKVLGDQRRPSLPALH--FIKGAGK--KESSRHGGPHCNVFVEHEALQ---RPVASD 55

Query: 68  SNTPGIREAG--------------SEDIIVVALYDYEAIHHEDLSFQKGDQMVVL--EES 111
               G+ EA               ++  + VALYD+ A     LS  KG+++ VL    +
Sbjct: 56  FEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHN 115

Query: 112 GEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIR 171
           GEW +A++     +G++PSNY+  V+SLE   W+   +SR  AE  LL+ G + GSF++R
Sbjct: 116 GEWCEAQT--KNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAE-YLLSSG-INGSFLVR 171

Query: 172 DSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGND 231
           +SE++ G  S+S+R Y+ R    V HY+I T  +G  Y+S  S F+TL ELV H+    D
Sbjct: 172 ESESSPGQRSISLR-YEGR----VYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVAD 226

Query: 232 GLCQKLSVPCMSSKPQKPW------EKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT 285
           GL   L  P  + K  KP         D WE+ R  + ++ KLG GQ+GEV+   + K++
Sbjct: 227 GLITTLHYP--APKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYS 284

Query: 286 -KVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEP-IYIITEFMAKGSLLD 343
             VAVKT+K  +M VE FL EA VMK ++H  LV+L  V T+EP  YIITEFM  G+LLD
Sbjct: 285 LTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLD 344

Query: 344 FLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLA 403
           +L+     +     L+  + QI+  M ++E++N+IHRDL A N LV  + + K+ADFGL+
Sbjct: 345 YLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLS 404

Query: 404 RVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSN 463
           R++  + YTA  GAKFPIKWTAPE++ +  F+IKSDVW+FG+LL EI TYG  PYPG+  
Sbjct: 405 RLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDL 464

Query: 464 PEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFY 515
            +V   LE+ YRM RPE CPE++Y +M  CW+  P +RP+F  I    +  +
Sbjct: 465 SQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMF 516


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  358 bits (918), Expect = 9e-99
 Identities = 196/444 (44%), Positives = 279/444 (62%), Gaps = 21/444 (4%)

Query: 82  IVVALYDYEAIHHEDLSFQKGDQMVVL--EESGEWWKARSLATRKEGYIPSNYVARVDSL 139
           + VALYD+ A     LS  KG+++ VL    +GEW +A++     +G++PSNY+  V+SL
Sbjct: 65  LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYITPVNSL 122

Query: 140 ETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYK 199
           E   W+   +SR  AE  LL+ G + GSF++R+SE++ G  S+S+R Y+ R    V HY+
Sbjct: 123 EKHSWYHGPVSRNAAE-YLLSSG-INGSFLVRESESSPGQRSISLR-YEGR----VYHYR 175

Query: 200 IRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPW------EKD 253
           I T  +G  Y+S  S F+TL ELV H+    DGL   L  P  + K  KP         D
Sbjct: 176 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP--APKRNKPTVYGVSPNYD 233

Query: 254 AWEIPRESLKLEKKLGAGQFGEVWMATYNKHT-KVAVKTMKPGSMSVEAFLAEANVMKTL 312
            WE+ R  + ++ KLG GQ+GEV+   + K++  VAVKT+K  +M VE FL EA VMK +
Sbjct: 234 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI 293

Query: 313 QHDKLVKLHAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAF 371
           +H  LV+L  V T+EP  YIITEFM  G+LLD+L+     +     L+  + QI+  M +
Sbjct: 294 KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY 353

Query: 372 IEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINF 431
           +E++N+IHRDL A N LV  + + K+ADFGL+R++  + YTA  GAKFPIKWTAPE++ +
Sbjct: 354 LEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 413

Query: 432 GSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMM 491
             F+IKSDVW+FG+LL EI TYG  PYPG+   +V   LE+ YRM RPE CPE++Y +M 
Sbjct: 414 NKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMR 473

Query: 492 RCWKNRPEERPTFEYIQSVLDDFY 515
            CW+  P +RP+F  I    +  +
Sbjct: 474 ACWQWNPSDRPSFAEIHQAFETMF 497


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  357 bits (916), Expect = 1e-98
 Identities = 207/485 (42%), Positives = 296/485 (61%), Gaps = 27/485 (5%)

Query: 31  QVGGNTFSKTETSASPH-CPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDY 89
           + G N F++ E    P+ C V   +P +  +    S   N  G  E  S+  + VALYD+
Sbjct: 43  ETGFNIFTQHEALHRPYGCDV---EPQALNEAIRWSSKENLLGATE--SDPNLFVALYDF 97

Query: 90  EAIHHEDLSFQKGDQMVVL--EESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFK 147
            A     LS  KG+++ VL   ++GEW + RS     +G++PSNY+  V+SLE   W+  
Sbjct: 98  VASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSLEKHSWYHG 155

Query: 148 GISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGG 207
            +SR  AE  L +  N  GSF++R+SE++ G  S+S+R Y+ R    V HY+I T  +G 
Sbjct: 156 PVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-YEGR----VYHYRINTTADGK 208

Query: 208 FYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWE------KDAWEIPRES 261
            Y++  S FSTL ELV H+    DGL   L  P  + K  KP         D WE+ R  
Sbjct: 209 VYVTAESRFSTLAELVHHHSTVADGLVTTLHYP--APKCNKPTVYGVSPIHDKWEMERTD 266

Query: 262 LKLEKKLGAGQFGEVWMATYNKHT-KVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKL 320
           + ++ KLG GQ+GEV++  + K++  VAVKT+K  +M VE FL EA VMK ++H  LV+L
Sbjct: 267 ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL 326

Query: 321 HAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIH 379
             V T EP  YI+TE+M  G+LLD+L+     +     L+  + QI+  M ++E++N+IH
Sbjct: 327 LGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIH 386

Query: 380 RDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSD 439
           RDL A N LV  + V K+ADFGL+R++  + YTA  GAKFPIKWTAPE++ + +F+IKSD
Sbjct: 387 RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD 446

Query: 440 VWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPE 499
           VW+FG+LL EI TYG  PYPG+   +V   LE+GYRM +PE CP ++Y +M  CWK  P 
Sbjct: 447 VWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPA 506

Query: 500 ERPTF 504
           +RP+F
Sbjct: 507 DRPSF 511


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  355 bits (910), Expect = 7e-98
 Identities = 199/450 (44%), Positives = 281/450 (62%), Gaps = 23/450 (5%)

Query: 65  SHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVL--EESGEWWKARSLAT 122
           S   N  G  E  S+  + VALYD+ A     LS  KG+++ VL   ++GEW + RS   
Sbjct: 81  SSKENLLGATE--SDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--K 136

Query: 123 RKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSL 182
             +G++PSNY+  V+SLE   W+   +SR  AE  L +  N  GSF++R+SE++ G  S+
Sbjct: 137 NGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSI 194

Query: 183 SVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCM 242
           S+R Y+ R    V HY+I T  +G  Y++  S FSTL ELV H+    DGL   L  P  
Sbjct: 195 SLR-YEGR----VYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP-- 247

Query: 243 SSKPQKPWE------KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT-KVAVKTMKPG 295
           + K  KP         D WE+ R  + ++ KLG GQ+GEV++  + K++  VAVKT+K  
Sbjct: 248 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED 307

Query: 296 SMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQP 354
           +M VE FL EA VMK ++H  LV+L  V T EP  YI+TE+M  G+LLD+L+     +  
Sbjct: 308 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT 367

Query: 355 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAR 414
              L+  + QI+  M ++E++N+IHRDL A N LV  + V K+ADFGL+R++  + YTA 
Sbjct: 368 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH 427

Query: 415 EGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY 474
            GAKFPIKWTAPE++ + +F+IKSDVW+FG+LL EI TYG  PYPG+   +V   LE+GY
Sbjct: 428 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY 487

Query: 475 RMPRPENCPEELYNIMMRCWKNRPEERPTF 504
           RM +PE CP ++Y +M  CWK  P +RP+F
Sbjct: 488 RMEQPEGCPPKVYELMRACWKWSPADRPSF 517


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  355 bits (910), Expect = 7e-98
 Identities = 199/450 (44%), Positives = 281/450 (62%), Gaps = 23/450 (5%)

Query: 65  SHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVL--EESGEWWKARSLAT 122
           S   N  G  E  S+  + VALYD+ A     LS  KG+++ VL   ++GEW + RS   
Sbjct: 96  SSKENLLGATE--SDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--K 151

Query: 123 RKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSL 182
             +G++PSNY+  V+SLE   W+   +SR  AE  L +  N  GSF++R+SE++ G  S+
Sbjct: 152 NGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSI 209

Query: 183 SVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCM 242
           S+R Y+ R    V HY+I T  +G  Y++  S FSTL ELV H+    DGL   L  P  
Sbjct: 210 SLR-YEGR----VYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP-- 262

Query: 243 SSKPQKPWE------KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT-KVAVKTMKPG 295
           + K  KP         D WE+ R  + ++ KLG GQ+GEV++  + K++  VAVKT+K  
Sbjct: 263 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED 322

Query: 296 SMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQP 354
           +M VE FL EA VMK ++H  LV+L  V T EP  YI+TE+M  G+LLD+L+     +  
Sbjct: 323 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT 382

Query: 355 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAR 414
              L+  + QI+  M ++E++N+IHRDL A N LV  + V K+ADFGL+R++  + YTA 
Sbjct: 383 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH 442

Query: 415 EGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY 474
            GAKFPIKWTAPE++ + +F+IKSDVW+FG+LL EI TYG  PYPG+   +V   LE+GY
Sbjct: 443 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY 502

Query: 475 RMPRPENCPEELYNIMMRCWKNRPEERPTF 504
           RM +PE CP ++Y +M  CWK  P +RP+F
Sbjct: 503 RMEQPEGCPPKVYELMRACWKWSPADRPSF 532


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  355 bits (910), Expect = 7e-98
 Identities = 199/450 (44%), Positives = 281/450 (62%), Gaps = 23/450 (5%)

Query: 65  SHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVL--EESGEWWKARSLAT 122
           S   N  G  E  S+  + VALYD+ A     LS  KG+++ VL   ++GEW + RS   
Sbjct: 81  SSKENLLGATE--SDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--K 136

Query: 123 RKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSL 182
             +G++PSNY+  V+SLE   W+   +SR  AE  L +  N  GSF++R+SE++ G  S+
Sbjct: 137 NGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSI 194

Query: 183 SVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCM 242
           S+R Y+ R    V HY+I T  +G  Y++  S FSTL ELV H+    DGL   L  P  
Sbjct: 195 SLR-YEGR----VYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP-- 247

Query: 243 SSKPQKPWE------KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT-KVAVKTMKPG 295
           + K  KP         D WE+ R  + ++ KLG GQ+GEV++  + K++  VAVKT+K  
Sbjct: 248 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED 307

Query: 296 SMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQP 354
           +M VE FL EA VMK ++H  LV+L  V T EP  YI+TE+M  G+LLD+L+     +  
Sbjct: 308 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT 367

Query: 355 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAR 414
              L+  + QI+  M ++E++N+IHRDL A N LV  + V K+ADFGL+R++  + YTA 
Sbjct: 368 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH 427

Query: 415 EGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY 474
            GAKFPIKWTAPE++ + +F+IKSDVW+FG+LL EI TYG  PYPG+   +V   LE+GY
Sbjct: 428 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY 487

Query: 475 RMPRPENCPEELYNIMMRCWKNRPEERPTF 504
           RM +PE CP ++Y +M  CWK  P +RP+F
Sbjct: 488 RMEQPEGCPPKVYELMRACWKWSPADRPSF 517


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  355 bits (910), Expect = 7e-98
 Identities = 199/450 (44%), Positives = 281/450 (62%), Gaps = 23/450 (5%)

Query: 65  SHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVL--EESGEWWKARSLAT 122
           S   N  G  E  S+  + VALYD+ A     LS  KG+++ VL   ++GEW + RS   
Sbjct: 60  SSKENLLGATE--SDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--K 115

Query: 123 RKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSL 182
             +G++PSNY+  V+SLE   W+   +SR  AE  L +  N  GSF++R+SE++ G  S+
Sbjct: 116 NGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSI 173

Query: 183 SVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCM 242
           S+R Y+ R    V HY+I T  +G  Y++  S FSTL ELV H+    DGL   L  P  
Sbjct: 174 SLR-YEGR----VYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP-- 226

Query: 243 SSKPQKPWE------KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT-KVAVKTMKPG 295
           + K  KP         D WE+ R  + ++ KLG GQ+GEV++  + K++  VAVKT+K  
Sbjct: 227 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED 286

Query: 296 SMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQP 354
           +M VE FL EA VMK ++H  LV+L  V T EP  YI+TE+M  G+LLD+L+     +  
Sbjct: 287 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT 346

Query: 355 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAR 414
              L+  + QI+  M ++E++N+IHRDL A N LV  + V K+ADFGL+R++  + YTA 
Sbjct: 347 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH 406

Query: 415 EGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY 474
            GAKFPIKWTAPE++ + +F+IKSDVW+FG+LL EI TYG  PYPG+   +V   LE+GY
Sbjct: 407 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY 466

Query: 475 RMPRPENCPEELYNIMMRCWKNRPEERPTF 504
           RM +PE CP ++Y +M  CWK  P +RP+F
Sbjct: 467 RMEQPEGCPPKVYELMRACWKWSPADRPSF 496


>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
          Length = 451

 Score =  349 bits (896), Expect = 3e-96
 Identities = 182/437 (41%), Positives = 272/437 (62%), Gaps = 12/437 (2%)

Query: 84  VALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL----ATRKEGYIPSNYVARVDSL 139
           V L+D+++   E+LSF+ GD   V  +  +WW A  L        +GY+P NY+A  +++
Sbjct: 14  VGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETV 73

Query: 140 ETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYK 199
           E+E WFF  ISR +A R+L A GN  G+F+IR SE     Y LSVRD        V+HYK
Sbjct: 74  ESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQ-----AVRHYK 128

Query: 200 IRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPR 259
           I     G  +++   +F +L ELV++++  +     +L+ PC   +P+     D WE PR
Sbjct: 129 IWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPR 188

Query: 260 ESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFL-AEANVMKTLQHDKLV 318
           E   L +KLG+G FGEV+   +    +VA+K +   ++  +  L +E   MK L+H  ++
Sbjct: 189 EEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHIL 248

Query: 319 KLHAVVTK-EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNY 377
            L+AVV+  +P+YIITE MAKGSLL+ L+  +    P+ +L+D + Q+AEGM ++E +NY
Sbjct: 249 ALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNY 308

Query: 378 IHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIK 437
           IHRDL A NILV  + +CK+ DFGLAR+I+++ Y + +    P KWTAPEA++ G ++ K
Sbjct: 309 IHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHYSTK 367

Query: 438 SDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNR 497
           SDVWSFGILL E+ + G++PYPGMSN E    ++ GYRMP P  CP  ++ +M+ CW   
Sbjct: 368 SDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRD 427

Query: 498 PEERPTFEYIQSVLDDF 514
           PE+RP F+ ++  L  F
Sbjct: 428 PEQRPCFKALRERLSSF 444


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score =  327 bits (838), Expect = 2e-89
 Identities = 179/450 (39%), Positives = 274/450 (60%), Gaps = 18/450 (4%)

Query: 75  EAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEE-SGEWWKARSLATRKEGYIPSNYV 133
           E   E I V ALYD+      +L+ ++ ++ ++LE+ +  WWKAR      EG IPSNYV
Sbjct: 79  EVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYV 137

Query: 134 A--RVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQ 191
              ++ +LE  EW+ + I+R  AE  LL   +  G+F++RDS    GSY++SV     R 
Sbjct: 138 TENKITNLEIYEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGARRS 195

Query: 192 GDT-VKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP------CMSS 244
            +  +KHY+I+  D+G +Y++ R  F ++ EL+ +++    GL  +L  P      C+ +
Sbjct: 196 TEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPA 255

Query: 245 KPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLA 304
                +EK  WEI    L   K++G+GQFG V +  +  H +VA+K +  GSMS E F+ 
Sbjct: 256 TAGFSYEK--WEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIE 313

Query: 305 EANVMKTLQHDKLVKLHAV-VTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSA 363
           EA VM  L H KLV+L+ V + ++P+YI+TEFM  G LL++L+ ++G K     L+    
Sbjct: 314 EAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG-KLRKEMLLSVCQ 372

Query: 364 QIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKW 423
            I EGM ++E+  YIHRDL A N LVS++ + KI+DFG+ R + D+EY +  GAKFPIKW
Sbjct: 373 DICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKW 432

Query: 424 TAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP 483
           + PE   F  ++ KSDVWSFG+L+ E+ T G++P+   SN +V+ A+  G+R+ RP   P
Sbjct: 433 SPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAP 492

Query: 484 EELYNIMMRCWKNRPEERPTF-EYIQSVLD 512
             +Y +M  CW  +PE RPTF E +++V +
Sbjct: 493 MSIYEVMYSCWHEKPEGRPTFAELLRAVTE 522


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  325 bits (834), Expect = 5e-89
 Identities = 183/510 (35%), Positives = 292/510 (57%), Gaps = 21/510 (4%)

Query: 28  KFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK---PGPNSHNSNTPG---IREAGSEDI 81
           KF   G     +     +P C  Y    +S  K   P P +     P    + E  + + 
Sbjct: 123 KFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEE 182

Query: 82  IVVALYDYEAIHHEDLSFQKGDQMVVLEESG-EWWKARSLATRKEGYIPSNYVA--RVDS 138
           IVVA+YD++A    DL  ++G + ++LE++   WW+AR      EGYIPSNYV   + ++
Sbjct: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241

Query: 139 LETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDT-VKH 197
           L+  EW+ + ++R  AE QLL   +  G FM+RDS +  G Y++S+      +G +  +H
Sbjct: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299

Query: 198 YKIR--TLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKP----WE 251
           Y I+  T     +Y++ +  F ++ E+++++K    GL  +L  P        P    + 
Sbjct: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359

Query: 252 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 311
            + WEI    L   ++LG+G FG V +  +    KVA+K ++ G+M  E F+ EA VM  
Sbjct: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMK 419

Query: 312 LQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 370
           L H KLV+L+ V T++ PIYI+TEFM +G LL+FL+  +G       L+     + EGM 
Sbjct: 420 LTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGME 478

Query: 371 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 430
           ++E+ ++IHRDL A N LVS + V K++DFG+AR + D++YT+  GAKFP+KW  PE  N
Sbjct: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538

Query: 431 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIM 490
           +  F+ KSDVWSFG+L+ E+ T GR+P+   +N EV+  + RG+R+ +P+     +Y +M
Sbjct: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598

Query: 491 MRCWKNRPEERPTFEYIQSVLDDFYTATES 520
           +RCW+ +PE RP+FE +   +D+     E+
Sbjct: 599 LRCWQEKPEGRPSFEDLLRTIDELVECEET 628


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score =  323 bits (827), Expect = 3e-88
 Identities = 175/441 (39%), Positives = 265/441 (60%), Gaps = 17/441 (3%)

Query: 83  VVALYDYEAIHHEDLSFQKGDQMVVLEESG-EWWKARSLATRKEGYIPSNYVARV-DSLE 140
           VVALYDY  ++  DL  +KGD+  +LEES   WW+AR     +EGYIPSNYV    DS+E
Sbjct: 219 VVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIE 277

Query: 141 TEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGD---TVKH 197
             EW+ K ++R  AE QLL      G F++RDS    G Y++SV  +    GD    ++H
Sbjct: 278 MYEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSV--FAKSTGDPQGVIRH 333

Query: 198 YKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKD---- 253
           Y + +     +Y++ +  FST+ EL+++++  + GL  +L  P        P        
Sbjct: 334 YVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYG 393

Query: 254 AWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQ 313
           +WEI  + L   K+LG GQFG V    +     VA+K +K GSMS + F+ EA VM  L 
Sbjct: 394 SWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLS 453

Query: 314 HDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFI 372
           H+KLV+L+ V TK+ PI+IITE+MA G LL++L+      Q   +L++    + E M ++
Sbjct: 454 HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQT-QQLLEMCKDVCEAMEYL 512

Query: 373 EQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG 432
           E + ++HRDL A N LV+   V K++DFGL+R + D+EYT+  G+KFP++W+ PE + + 
Sbjct: 513 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYS 572

Query: 433 SFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMR 492
            F+ KSD+W+FG+L+ EI + G++PY   +N E    + +G R+ RP    E++Y IM  
Sbjct: 573 KFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYS 632

Query: 493 CWKNRPEERPTFEYIQS-VLD 512
           CW  + +ERPTF+ + S +LD
Sbjct: 633 CWHEKADERPTFKILLSNILD 653


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  309 bits (791), Expect = 5e-84
 Identities = 172/469 (36%), Positives = 270/469 (57%), Gaps = 18/469 (3%)

Query: 48  CPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVV 107
           C  Y P   ++ KP P +   N   + E   E+ +V+ALYDY+    ++L+ ++ ++  +
Sbjct: 143 CAQYDPTKNASKKPLPPTPEDNRRPLWEP--EETVVIALYDYQTNDPQELALRRNEEYCL 200

Query: 108 LEESG-EWWKARSLATRKEGYIPSNYVARV--DSLETEEWFFKGISRKDAERQLLAPGNM 164
           L+ S   WW+ +      EGY+PS+Y+     ++LET EW+ K ISR  AE+ LL  G  
Sbjct: 201 LDSSEIHWWRVQD-RNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKE 259

Query: 165 LGSFMIRDSETTKGSYSLSV--RDYDPRQGDTVKHYKIR-TLDNGG-FYISPRSTFSTLQ 220
            G+FM+RDS T  G+Y++SV  +         +KHY I+ T DN   +Y++ +  F ++ 
Sbjct: 260 -GAFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIP 317

Query: 221 ELVDHYKKGNDGLCQKLSVPCMSSKPQKP----WEKDAWEIPRESLKLEKKLGAGQFGEV 276
            L+++++    GL  +L  P    + + P         W I    L   +++G+GQFG V
Sbjct: 318 LLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLV 377

Query: 277 WMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKE-PIYIITEF 335
            +  +    KVA+KT++ G+MS E F+ EA VM  L H KLV+L+ V  ++ PI ++ EF
Sbjct: 378 HLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEF 437

Query: 336 MAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVC 395
           M  G L D+L++  G       L+     + EGMA++E+   IHRDL A N LV  + V 
Sbjct: 438 MEHGCLSDYLRTQRGLFAA-ETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVI 496

Query: 396 KIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGR 455
           K++DFG+ R + D++YT+  G KFP+KW +PE  +F  ++ KSDVWSFG+L+ E+ + G+
Sbjct: 497 KVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGK 556

Query: 456 IPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTF 504
           IPY   SN EV+  +  G+R+ +P      +Y IM  CWK RPE+RP F
Sbjct: 557 IPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAF 605


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  285 bits (729), Expect = 7e-77
 Identities = 169/446 (37%), Positives = 248/446 (55%), Gaps = 28/446 (6%)

Query: 84  VALYDYEAIHHEDLSFQKGDQM--VVLEESGEWWKARSLATRKEGYIPSNYVARVDS--- 138
           +A Y++     +DL F KGD +  V + +   W+KA++   R EG IP+NYV + +    
Sbjct: 15  IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGR-EGIIPANYVQKREGVKA 73

Query: 139 ---LETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTV 195
              L    WF   I+R+ AER L  P    G F++R+S    G Y+L V          V
Sbjct: 74  GTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSC-----DGKV 126

Query: 196 KHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSS---KPQKPWEK 252
           +HY+I         I     F  L +LV+HY    DGLC +L  P +       Q  + +
Sbjct: 127 EHYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYR 185

Query: 253 DAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTL 312
             W +  + LKL + +G G+FG+V +  Y +  KVAVK +K    + +AFLAEA+VM  L
Sbjct: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDY-RGNKVAVKCIK-NDATAQAFLAEASVMTQL 243

Query: 313 QHDKLVKLHAVVTKEP--IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 370
           +H  LV+L  V+ +E   +YI+TE+MAKGSL+D+L+S   S      L+ FS  + E M 
Sbjct: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303

Query: 371 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 430
           ++E  N++HRDL A N+LVS   V K++DFGL +     + T     K P+KWTAPEA+ 
Sbjct: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALR 359

Query: 431 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIM 490
              F+ KSDVWSFGILL EI ++GR+PYP +   +V+  +E+GY+M  P+ CP  +Y +M
Sbjct: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 419

Query: 491 MRCWKNRPEERPTFEYIQSVLDDFYT 516
             CW      RP+F  ++  L+   T
Sbjct: 420 KNCWHLDAAMRPSFLQLREQLEHIKT 445


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,586,206
Number of Sequences: 37866
Number of extensions: 1019265
Number of successful extensions: 5000
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 719
Number of HSP's successfully gapped in prelim test: 317
Number of HSP's that attempted gapping in prelim test: 2643
Number of HSP's gapped (non-prelim): 1347
length of query: 526
length of database: 18,247,518
effective HSP length: 107
effective length of query: 419
effective length of database: 14,195,856
effective search space: 5948063664
effective search space used: 5948063664
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.