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Search of human proteins with 30581135
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30581135 structural maintenance of chromosomes 1A [Homo
sapiens]
(1233 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] 2401 0.0
gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 ... 1343 0.0
gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 ... 360 4e-99
gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 ... 360 4e-99
gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens] 283 7e-76
gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens] 283 7e-76
gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens] 283 7e-76
gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens] 232 2e-60
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 144 4e-34
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 144 4e-34
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 144 4e-34
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 139 1e-32
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 137 6e-32
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 133 9e-31
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 133 1e-30
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 133 1e-30
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 133 1e-30
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 133 1e-30
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 132 3e-30
gi|156104908 myosin heavy chain 6 [Homo sapiens] 131 3e-30
gi|148746195 trichohyalin [Homo sapiens] 129 2e-29
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 129 2e-29
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 129 2e-29
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 127 5e-29
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 127 7e-29
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 126 1e-28
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 126 1e-28
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 126 1e-28
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 126 1e-28
gi|19924129 RAD50 homolog isoform 1 [Homo sapiens] 124 6e-28
>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
Length = 1233
Score = 2401 bits (6222), Expect = 0.0
Identities = 1233/1233 (100%), Positives = 1233/1233 (100%)
Query: 1 MGFLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKT 60
MGFLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKT
Sbjct: 1 MGFLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKT 60
Query: 61 LRDLIHGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEE 120
LRDLIHGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEE
Sbjct: 61 LRDLIHGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEE 120
Query: 121 LEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEE 180
LEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEE
Sbjct: 121 LEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEE 180
Query: 181 DTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNK 240
DTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNK
Sbjct: 181 DTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNK 240
Query: 241 ELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIK 300
ELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIK
Sbjct: 241 ELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIK 300
Query: 301 AKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQS 360
AKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQS
Sbjct: 301 AKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQS 360
Query: 361 QGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAK 420
QGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAK
Sbjct: 361 QGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAK 420
Query: 421 IKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQV 480
IKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQV
Sbjct: 421 IKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQV 480
Query: 481 MEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGK 540
MEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGK
Sbjct: 481 MEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGK 540
Query: 541 NMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRY 600
NMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRY
Sbjct: 541 NMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRY 600
Query: 601 EPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLK 660
EPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLK
Sbjct: 601 EPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLK 660
Query: 661 AKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLE 720
AKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLE
Sbjct: 661 AKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLE 720
Query: 721 QTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEF 780
QTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEF
Sbjct: 721 QTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEF 780
Query: 781 CREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQ 840
CREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQ
Sbjct: 781 CREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQ 840
Query: 841 TVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGG 900
TVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGG
Sbjct: 841 TVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGG 900
Query: 901 ANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGE 960
ANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGE
Sbjct: 901 ANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGE 960
Query: 961 DSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRI 1020
DSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRI
Sbjct: 961 DSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRI 1020
Query: 1021 AAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATN 1080
AAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATN
Sbjct: 1021 AAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATN 1080
Query: 1081 IDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALAL 1140
IDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALAL
Sbjct: 1081 IDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALAL 1140
Query: 1141 LFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESL 1200
LFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESL
Sbjct: 1141 LFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESL 1200
Query: 1201 IGVYPEQGDCVISKVLTFDLTKYPDANPNPNEQ 1233
IGVYPEQGDCVISKVLTFDLTKYPDANPNPNEQ
Sbjct: 1201 IGVYPEQGDCVISKVLTFDLTKYPDANPNPNEQ 1233
>gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 [Homo
sapiens]
Length = 1235
Score = 1343 bits (3476), Expect = 0.0
Identities = 658/1225 (53%), Positives = 919/1225 (75%), Gaps = 4/1225 (0%)
Query: 1 MGFLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKT 60
M L+L+ +ENFKS++GRQ+IGPF+RFT IIGPNGSGKSN+MDA+SFV+GEK +NLRVK
Sbjct: 1 MAHLELLLVENFKSWRGRQVIGPFRRFTCIIGPNGSGKSNVMDALSFVMGEKIANLRVKN 60
Query: 61 LRDLIHGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEE 120
+++LIHGA +GKP ++ A V ++Y EE E++TFAR+I GG SE++ N+ +V Y E
Sbjct: 61 IQELIHGAHIGKPISSSASVKIIYVEESGEEKTFARIIRGGCSEFRFNDNLVSRSVYIAE 120
Query: 121 LEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEE 180
LEK+GI++KA+N LVFQG VESI++K PKERT FEEIS SGEL EY+++K+++ KAEE
Sbjct: 121 LEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEE 180
Query: 181 DTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNK 240
D QFN+++KKNIAAER++AK EKEEA+RYQ L +E+ ++QLQLF+LYHNE +I LN
Sbjct: 181 DAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNT 240
Query: 241 ELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIK 300
+L N+++ ++ + E+ +K +KKE G + R+ QQ EKE+K ++ LNQKRPQYIK
Sbjct: 241 KLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIK 300
Query: 301 AKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQS 360
AKENTSH +KKL+ AKKS+++++K K++ D+ LE E+ ++ A + FE+++EEE
Sbjct: 301 AKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILH 360
Query: 361 QGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAK 420
+ RD+ LE +Q+ +Y LKE+ K+ AT+ Q+LEK +QK D++RL E+R+ E +
Sbjct: 361 KKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGN 420
Query: 421 IKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQV 480
+KQ +IE+++KRIEKLEEY T L+E+K+ E L +E+E K R+ E N+ELN +
Sbjct: 421 LKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLI 480
Query: 481 MEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGK 540
+L +A ID E RQQ++AE++E +KRLYP SV+GRL DLC P KKYQ+AVTKV G+
Sbjct: 481 RSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGR 540
Query: 541 NMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRY 600
+ AI+V SEK +DCI+++KE+R EPETFL LDYL++KP +E+LRELKG K+VIDVI+
Sbjct: 541 FITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKT 600
Query: 601 EPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLK 660
+ P +KK +Q+ CGN LVC+ +E+AR IA G +R KTVALDGTLF KSGVISGG+SDLK
Sbjct: 601 QFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLK 660
Query: 661 AKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLE 720
KAR WDEK + L++++ + +ELK MK RKE +L+Q+Q+ G Q RLKYSQ++LE
Sbjct: 661 YKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELE 720
Query: 721 QTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEF 780
K +HL QE+S+L+SEL N + + I+ R+R +K+ +EK+++VED++F+ F
Sbjct: 721 MIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHF 780
Query: 781 CREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQ 840
C EIGV NIREFE + VKRQ EI +KRLEFE QKTRL +QL++ ++ LK+ +K++ ++
Sbjct: 781 CEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKE 840
Query: 841 TVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGG 900
T++K +I+ LKK E+ ++ ++E MA+ Q LK+ + + S ++EE RKK
Sbjct: 841 TIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLA 900
Query: 901 ANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGE 960
++E+ LQKEV +I+T LEQKR ++HNLL CK+QDI++ L G++DDI + E ++ E
Sbjct: 901 VDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAE 960
Query: 961 DSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRI 1020
+Q IY +E EIDY L EDLK Q+++EI+ + L Q++ Q+ +L +
Sbjct: 961 ----STQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKT 1016
Query: 1021 AAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATN 1080
AAPN++A+E L++VRDKFQE++D FEA+RK A+ +Q FEQ+KK R+D F CFE V+ +
Sbjct: 1017 AAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSIS 1076
Query: 1081 IDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALAL 1140
ID+IYK L RN+SAQAFL PENPEEPYL+GI+YNCVAPGKRF PMDNLSGGEK VAALAL
Sbjct: 1077 IDQIYKKLCRNNSAQAFLSPENPEEPYLEGISYNCVAPGKRFMPMDNLSGGEKCVAALAL 1136
Query: 1141 LFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESL 1200
LFA+HS++PAPFFVLDE+DAALDNTNIGKV++YIKEQ+ FQ IVISLKEEFY++A++L
Sbjct: 1137 LFAVHSFRPAPFFVLDEVDAALDNTNIGKVSSYIKEQTQDQFQMIVISLKEEFYSRADAL 1196
Query: 1201 IGVYPEQGDCVISKVLTFDLTKYPD 1225
IG+YPE DC+ S+VLT DL++YPD
Sbjct: 1197 IGIYPEYDDCMFSRVLTLDLSQYPD 1221
>gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
sapiens]
Length = 1288
Score = 360 bits (925), Expect = 4e-99
Identities = 337/1300 (25%), Positives = 603/1300 (46%), Gaps = 191/1300 (14%)
Query: 10 ENFKSYKGRQIIGPF-QRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTLRDLIHGA 68
+NFKSY G +I+GPF +RF+ IIGPNGSGKSN++D++ FV G + +R K L LIH +
Sbjct: 90 QNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNS 149
Query: 69 PVGKPAAN---RAFVSMVYSEEGAE-----------DRTFARVIVGGSSEYKINNKVVQL 114
K + + +EG + RT R +S Y I+ K
Sbjct: 150 DEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACR---DNTSVYHISGKKKTF 206
Query: 115 HEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTA-------LFEEISRSGELAQE 167
+ L GI + FL+ QG VE IAM PK +T E+I G L +
Sbjct: 207 KDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEP 266
Query: 168 YDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVR--------- 218
+ + E +R K + E+ + EK A + L++E+ R
Sbjct: 267 IKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYY 326
Query: 219 --------AQVQLQLFKLYHNEVEIEK----LNKELASKNKEIEKDKKRMDKVEDELKEK 266
A+++ Q K++ + EI + L+ E+ +KNK+++ +K+++K+ ++E
Sbjct: 327 IYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEEN 386
Query: 267 KKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHY 326
K++ ++ E Q+ +++K S+ + Q K KE K+++ ++ N
Sbjct: 387 KEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKE----KVEEFKSIPAKSNNIINET 442
Query: 327 KKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRA 386
R + LEKE EK +E + +++E+Q ++ E ++ + + EA +
Sbjct: 443 TTRN---NALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKM 499
Query: 387 ATLAQELEKFNRDQKADQDRLD------------LEERKKV--ETEAKIKQKLREIEENQ 432
EL+ + +L L+ERK + E K+ Q +E++E +
Sbjct: 500 DVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKE 559
Query: 433 KRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQ 492
K ++KL + T K L +L ++VE AK + +N+ +V+ DA I +
Sbjct: 560 KELQKLTQEETNFKS-------LVHDLFQKVEEAKSSL-AMNRSRGKVL----DAIIQEK 607
Query: 493 ESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKT 552
+S R PG +YGRL DL +KY +A++ +D I+VDS
Sbjct: 608 KSGR--------------IPG-IYGRLGDL-GAIDEKYDVAISSCCHA-LDYIVVDSIDI 650
Query: 553 GRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELK---GAKLVIDVIRYEPPHIKKAL 609
++C+ ++K Q TF+ LD + V +K+ E++ + D+++ + I++A
Sbjct: 651 AQECVNFLKRQNIGVATFIGLDKMAVWA--KKMTEIQTPENTPRLFDLVKVKDEKIRQAF 708
Query: 610 QYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEK 669
+A + LV DN++ A R+A+ +R + V L G + ++SG ++GG S + K R
Sbjct: 709 YFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVM-KGRMGSSL 767
Query: 670 AVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLA- 728
++ +E+ ++ +L+ K K ++++ + Q ++L++S+ ++ T + A
Sbjct: 768 VIEISEEEVNKMESQLQNDSK---KAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTAS 824
Query: 729 ----------LNLQEKSKLESELANFGPRINDIKRI---IQSREREMKDLKEKMNQVEDE 775
LN+Q K +LE+ + P K + + + + E + EK +VE E
Sbjct: 825 IQRLIEQEEYLNVQVK-ELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAE 883
Query: 776 VFEEFCREIGVRNIREFEEEKVKRQNE----IAKKRLEFENQKTRLGIQLDFEKNQLKED 831
V I E K+K Q + I K+ E + T+ + + L++
Sbjct: 884 VKRLH------NTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKA 937
Query: 832 QDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEM 891
QD V E+ +K E E++ L E +K +++ A++ +KN + A++S + + E
Sbjct: 938 QDSVLRTEKEIKDTEKEVDDLTAE----LKSLEDKAAEV--VKNTNAAEES-LPEIQKEH 990
Query: 892 EEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDIS 951
+ ++L + LQK+ +I+ KLEQ D H K++ +SK ++ I
Sbjct: 991 RNLLQELKVIQENEHALQKDALSIKLKLEQ--IDGHIAEHNSKIKYWHKEISKISLHPIE 1048
Query: 952 Q---EEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQ 1008
EE S + + + SI + AL+E E+K + + +
Sbjct: 1049 DNPIEEISVLSPEDLEAIKNPDSITNQIALLEARC-------------HEMKPNLGAIAE 1095
Query: 1009 KLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFD 1068
+++ LQR+A ++K+ RD F +QA+E ++K+R +
Sbjct: 1096 YKKKEELYLQRVAE-----LDKITYERDSF-----------------RQAYEDLRKQRLN 1133
Query: 1069 RFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNL 1128
F A F + + E Y+ L+ A+ L + +P+ +GI ++ P K ++ + NL
Sbjct: 1134 EFMAGFYIITNKLKENYQMLTLGGDAELEL--VDSLDPFSEGIMFSVRPPKKSWKKIFNL 1191
Query: 1129 SGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVIS 1188
SGGEKT+++LAL+FA+H YKP P + +DEIDAALD N+ VA YI EQ T N Q I+IS
Sbjct: 1192 SGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQ-TKNAQFIIIS 1250
Query: 1189 LKEEFYTKAESLIGVYPEQGDCVISKVLTFDLTKYPDANP 1228
L+ + ++ LIG+Y T+++TK NP
Sbjct: 1251 LRNNMFEISDRLIGIYK-----------TYNITKSVAVNP 1279
>gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
sapiens]
Length = 1288
Score = 360 bits (925), Expect = 4e-99
Identities = 337/1300 (25%), Positives = 603/1300 (46%), Gaps = 191/1300 (14%)
Query: 10 ENFKSYKGRQIIGPF-QRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTLRDLIHGA 68
+NFKSY G +I+GPF +RF+ IIGPNGSGKSN++D++ FV G + +R K L LIH +
Sbjct: 90 QNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNS 149
Query: 69 PVGKPAAN---RAFVSMVYSEEGAE-----------DRTFARVIVGGSSEYKINNKVVQL 114
K + + +EG + RT R +S Y I+ K
Sbjct: 150 DEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACR---DNTSVYHISGKKKTF 206
Query: 115 HEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTA-------LFEEISRSGELAQE 167
+ L GI + FL+ QG VE IAM PK +T E+I G L +
Sbjct: 207 KDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEP 266
Query: 168 YDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVR--------- 218
+ + E +R K + E+ + EK A + L++E+ R
Sbjct: 267 IKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYY 326
Query: 219 --------AQVQLQLFKLYHNEVEIEK----LNKELASKNKEIEKDKKRMDKVEDELKEK 266
A+++ Q K++ + EI + L+ E+ +KNK+++ +K+++K+ ++E
Sbjct: 327 IYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEEN 386
Query: 267 KKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHY 326
K++ ++ E Q+ +++K S+ + Q K KE K+++ ++ N
Sbjct: 387 KEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKE----KVEEFKSIPAKSNNIINET 442
Query: 327 KKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRA 386
R + LEKE EK +E + +++E+Q ++ E ++ + + EA +
Sbjct: 443 TTRN---NALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKM 499
Query: 387 ATLAQELEKFNRDQKADQDRLD------------LEERKKV--ETEAKIKQKLREIEENQ 432
EL+ + +L L+ERK + E K+ Q +E++E +
Sbjct: 500 DVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKE 559
Query: 433 KRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQ 492
K ++KL + T K L +L ++VE AK + +N+ +V+ DA I +
Sbjct: 560 KELQKLTQEETNFKS-------LVHDLFQKVEEAKSSL-AMNRSRGKVL----DAIIQEK 607
Query: 493 ESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKT 552
+S R PG +YGRL DL +KY +A++ +D I+VDS
Sbjct: 608 KSGR--------------IPG-IYGRLGDL-GAIDEKYDVAISSCCHA-LDYIVVDSIDI 650
Query: 553 GRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELK---GAKLVIDVIRYEPPHIKKAL 609
++C+ ++K Q TF+ LD + V +K+ E++ + D+++ + I++A
Sbjct: 651 AQECVNFLKRQNIGVATFIGLDKMAVWA--KKMTEIQTPENTPRLFDLVKVKDEKIRQAF 708
Query: 610 QYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEK 669
+A + LV DN++ A R+A+ +R + V L G + ++SG ++GG S + K R
Sbjct: 709 YFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVM-KGRMGSSL 767
Query: 670 AVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLA- 728
++ +E+ ++ +L+ K K ++++ + Q ++L++S+ ++ T + A
Sbjct: 768 VIEISEEEVNKMESQLQNDSK---KAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTAS 824
Query: 729 ----------LNLQEKSKLESELANFGPRINDIKRI---IQSREREMKDLKEKMNQVEDE 775
LN+Q K +LE+ + P K + + + + E + EK +VE E
Sbjct: 825 IQRLIEQEEYLNVQVK-ELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAE 883
Query: 776 VFEEFCREIGVRNIREFEEEKVKRQNE----IAKKRLEFENQKTRLGIQLDFEKNQLKED 831
V I E K+K Q + I K+ E + T+ + + L++
Sbjct: 884 VKRLH------NTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKA 937
Query: 832 QDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEM 891
QD V E+ +K E E++ L E +K +++ A++ +KN + A++S + + E
Sbjct: 938 QDSVLRTEKEIKDTEKEVDDLTAE----LKSLEDKAAEV--VKNTNAAEES-LPEIQKEH 990
Query: 892 EEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDIS 951
+ ++L + LQK+ +I+ KLEQ D H K++ +SK ++ I
Sbjct: 991 RNLLQELKVIQENEHALQKDALSIKLKLEQ--IDGHIAEHNSKIKYWHKEISKISLHPIE 1048
Query: 952 Q---EEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQ 1008
EE S + + + SI + AL+E E+K + + +
Sbjct: 1049 DNPIEEISVLSPEDLEAIKNPDSITNQIALLEARC-------------HEMKPNLGAIAE 1095
Query: 1009 KLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFD 1068
+++ LQR+A ++K+ RD F +QA+E ++K+R +
Sbjct: 1096 YKKKEELYLQRVAE-----LDKITYERDSF-----------------RQAYEDLRKQRLN 1133
Query: 1069 RFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNL 1128
F A F + + E Y+ L+ A+ L + +P+ +GI ++ P K ++ + NL
Sbjct: 1134 EFMAGFYIITNKLKENYQMLTLGGDAELEL--VDSLDPFSEGIMFSVRPPKKSWKKIFNL 1191
Query: 1129 SGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVIS 1188
SGGEKT+++LAL+FA+H YKP P + +DEIDAALD N+ VA YI EQ T N Q I+IS
Sbjct: 1192 SGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQ-TKNAQFIIIS 1250
Query: 1189 LKEEFYTKAESLIGVYPEQGDCVISKVLTFDLTKYPDANP 1228
L+ + ++ LIG+Y T+++TK NP
Sbjct: 1251 LRNNMFEISDRLIGIYK-----------TYNITKSVAVNP 1279
>gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 283 bits (724), Expect = 7e-76
Identities = 316/1265 (24%), Positives = 570/1265 (45%), Gaps = 179/1265 (14%)
Query: 4 LKLIEIENFKSYKGRQIIGPFQR-FTAIIGPNGSGKSNLMDAISFVLG-EKTSNLRVKTL 61
+K I +E FKSY R + F F AI G NGSGKSN++D+I F+LG S +R L
Sbjct: 3 IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNL 62
Query: 62 RDLIHGAPVGKPAANRAFVSMVYSE----------EGAEDRTFAR-VIVGGSSEYKINNK 110
+DL++ G+ +A VS+ + E ++ T R V++GG ++Y IN
Sbjct: 63 QDLVYKN--GQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
Query: 111 VVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDK 170
+ +G+ + +FL+ QG + + P E ++ EE + G EY K
Sbjct: 121 NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAA--GTRMYEYKK 178
Query: 171 RKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYH 230
+ A++ + KK + + E+E Q+LK+E L+ K+
Sbjct: 179 -----IAAQKTIE-----KKEAKLKEIKTILEEEITPTIQKLKEE---RSSYLEYQKVMR 225
Query: 231 NEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSE 290
EIE L++ + + +D K + +ELKE + ++ K+ E + +K+IK + E
Sbjct: 226 ---EIEHLSRLYIAYQFLLAEDTKV--RSAEELKEMQDKVIKLQEELSENDKKIKALNHE 280
Query: 291 LNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEF 350
+ + + K KE T ++ LE A L AQ+ K + D +K + E R+E
Sbjct: 281 IEELEKR--KDKE-TGGILRSLEDA---LAEAQRVNTKSQSAFDLKKKNLACEESKRKEL 334
Query: 351 EERMEEESQSQGRDLTLEENQVKKY----HRLKEEASKRAATLAQELEKFNRDQKADQDR 406
E+ M E+S++ L +E +VKK H L+E ++K A LA + FN
Sbjct: 335 EKNMVEDSKT----LAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSN 390
Query: 407 LDLEER-------------KKVETEAK-----IKQKLREIEENQKRIEKLEEYITTSKQS 448
D E K +TEAK +K +E++ Q ++K++ +++
Sbjct: 391 EDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEA 450
Query: 449 LEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIK 508
LE K+L+ +L E EM K +E NKE E L + R RQ S R E E++
Sbjct: 451 LEAVKRLKEKL--EAEMKKLNYEE-NKE-----ESLLEKR--RQLSRDIGRLKETYEALL 500
Query: 509 RLYPG---------------SVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTG 553
+P V G + L A+ V G+ + ++VD+E TG
Sbjct: 501 ARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTG 560
Query: 554 RDCIQYIKEQRGEPE---TFLPLDYLEVKP-TDEKLRELKG------AKLVIDVIRYEPP 603
+ ++ RGE + T +PL+ + + E LR + + + ++ Y+P
Sbjct: 561 KKLLE-----RGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKP- 614
Query: 604 HIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKA 663
++KA+++ G VCDN+++A+++AF +TV L G +F G +SGGA A
Sbjct: 615 ELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASI 674
Query: 664 RRWDEKAVD-----KLKEKKER-LTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQS 717
++ D ++KE + R L EEL K +L+Q Q +K ++
Sbjct: 675 LTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQ--------QWEMKTEEA 726
Query: 718 DLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVF 777
DL QTK + + + Q++ ++ +K+ I+ E +K+ KE + E++
Sbjct: 727 DLLQTKLQQSSYHKQQEE------------LDALKKTIEESEETLKNTKEIQRKAEEKY- 773
Query: 778 EEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHM 837
E+ ++ E E+ +R+ + A+K+L+ K D ++KE Q
Sbjct: 774 -----EVLENKMKNAEAER-ERELKDAQKKLDCAKTKA------DASSKKMKEKQ----- 816
Query: 838 WEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKK 897
Q V+ E+E+LK+E + + QL+ + + +S++ E+ + ++
Sbjct: 817 --QEVEAITLELEELKREHTSYKQ-------QLEAVNEAIKSYESQIEVMAAEVAKNKES 867
Query: 898 LGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSS 957
+ A +E+T ++ +TA +T ++ K ++ + +K+ K +IS+ + +
Sbjct: 868 VNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKI---KELDHNISKHKREA 924
Query: 958 QGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVL 1017
+ G+ ++S + I + + + +E QKL E + L
Sbjct: 925 E-----DGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKL 979
Query: 1018 QRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESV 1077
R NM+AM L +++ + + K E + +++ N ++ V
Sbjct: 980 GRNV--NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKV 1037
Query: 1078 ATNIDEIYKALSRNSSAQAFLGPENPE-EPYLDGINYNCVAPGKRFRP-MDNLSGGEKTV 1135
+ I+ L A A L P PE + LDG+ + VA G ++ + LSGG++++
Sbjct: 1038 NKDFGSIFSTLL--PGANAMLAP--PEGQTVLDGLEFK-VALGNTWKENLTELSGGQRSL 1092
Query: 1136 AALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYT 1195
AL+L+ ++ +KPAP ++LDE+DAALD ++ + ++ T + Q IV+SLKE +
Sbjct: 1093 VALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFT-HSQFIVVSLKEGMFN 1151
Query: 1196 KAESL 1200
A L
Sbjct: 1152 NANVL 1156
>gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 283 bits (724), Expect = 7e-76
Identities = 316/1265 (24%), Positives = 570/1265 (45%), Gaps = 179/1265 (14%)
Query: 4 LKLIEIENFKSYKGRQIIGPFQR-FTAIIGPNGSGKSNLMDAISFVLG-EKTSNLRVKTL 61
+K I +E FKSY R + F F AI G NGSGKSN++D+I F+LG S +R L
Sbjct: 3 IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNL 62
Query: 62 RDLIHGAPVGKPAANRAFVSMVYSE----------EGAEDRTFAR-VIVGGSSEYKINNK 110
+DL++ G+ +A VS+ + E ++ T R V++GG ++Y IN
Sbjct: 63 QDLVYKN--GQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
Query: 111 VVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDK 170
+ +G+ + +FL+ QG + + P E ++ EE + G EY K
Sbjct: 121 NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAA--GTRMYEYKK 178
Query: 171 RKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYH 230
+ A++ + KK + + E+E Q+LK+E L+ K+
Sbjct: 179 -----IAAQKTIE-----KKEAKLKEIKTILEEEITPTIQKLKEE---RSSYLEYQKVMR 225
Query: 231 NEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSE 290
EIE L++ + + +D K + +ELKE + ++ K+ E + +K+IK + E
Sbjct: 226 ---EIEHLSRLYIAYQFLLAEDTKV--RSAEELKEMQDKVIKLQEELSENDKKIKALNHE 280
Query: 291 LNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEF 350
+ + + K KE T ++ LE A L AQ+ K + D +K + E R+E
Sbjct: 281 IEELEKR--KDKE-TGGILRSLEDA---LAEAQRVNTKSQSAFDLKKKNLACEESKRKEL 334
Query: 351 EERMEEESQSQGRDLTLEENQVKKY----HRLKEEASKRAATLAQELEKFNRDQKADQDR 406
E+ M E+S++ L +E +VKK H L+E ++K A LA + FN
Sbjct: 335 EKNMVEDSKT----LAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSN 390
Query: 407 LDLEER-------------KKVETEAK-----IKQKLREIEENQKRIEKLEEYITTSKQS 448
D E K +TEAK +K +E++ Q ++K++ +++
Sbjct: 391 EDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEA 450
Query: 449 LEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIK 508
LE K+L+ +L E EM K +E NKE E L + R RQ S R E E++
Sbjct: 451 LEAVKRLKEKL--EAEMKKLNYEE-NKE-----ESLLEKR--RQLSRDIGRLKETYEALL 500
Query: 509 RLYPG---------------SVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTG 553
+P V G + L A+ V G+ + ++VD+E TG
Sbjct: 501 ARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTG 560
Query: 554 RDCIQYIKEQRGEPE---TFLPLDYLEVKP-TDEKLRELKG------AKLVIDVIRYEPP 603
+ ++ RGE + T +PL+ + + E LR + + + ++ Y+P
Sbjct: 561 KKLLE-----RGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKP- 614
Query: 604 HIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKA 663
++KA+++ G VCDN+++A+++AF +TV L G +F G +SGGA A
Sbjct: 615 ELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASI 674
Query: 664 RRWDEKAVD-----KLKEKKER-LTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQS 717
++ D ++KE + R L EEL K +L+Q Q +K ++
Sbjct: 675 LTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQ--------QWEMKTEEA 726
Query: 718 DLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVF 777
DL QTK + + + Q++ ++ +K+ I+ E +K+ KE + E++
Sbjct: 727 DLLQTKLQQSSYHKQQEE------------LDALKKTIEESEETLKNTKEIQRKAEEKY- 773
Query: 778 EEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHM 837
E+ ++ E E+ +R+ + A+K+L+ K D ++KE Q
Sbjct: 774 -----EVLENKMKNAEAER-ERELKDAQKKLDCAKTKA------DASSKKMKEKQ----- 816
Query: 838 WEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKK 897
Q V+ E+E+LK+E + + QL+ + + +S++ E+ + ++
Sbjct: 817 --QEVEAITLELEELKREHTSYKQ-------QLEAVNEAIKSYESQIEVMAAEVAKNKES 867
Query: 898 LGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSS 957
+ A +E+T ++ +TA +T ++ K ++ + +K+ K +IS+ + +
Sbjct: 868 VNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKI---KELDHNISKHKREA 924
Query: 958 QGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVL 1017
+ G+ ++S + I + + + +E QKL E + L
Sbjct: 925 E-----DGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKL 979
Query: 1018 QRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESV 1077
R NM+AM L +++ + + K E + +++ N ++ V
Sbjct: 980 GRNV--NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKV 1037
Query: 1078 ATNIDEIYKALSRNSSAQAFLGPENPE-EPYLDGINYNCVAPGKRFRP-MDNLSGGEKTV 1135
+ I+ L A A L P PE + LDG+ + VA G ++ + LSGG++++
Sbjct: 1038 NKDFGSIFSTLL--PGANAMLAP--PEGQTVLDGLEFK-VALGNTWKENLTELSGGQRSL 1092
Query: 1136 AALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYT 1195
AL+L+ ++ +KPAP ++LDE+DAALD ++ + ++ T + Q IV+SLKE +
Sbjct: 1093 VALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFT-HSQFIVVSLKEGMFN 1151
Query: 1196 KAESL 1200
A L
Sbjct: 1152 NANVL 1156
>gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 283 bits (724), Expect = 7e-76
Identities = 316/1265 (24%), Positives = 570/1265 (45%), Gaps = 179/1265 (14%)
Query: 4 LKLIEIENFKSYKGRQIIGPFQR-FTAIIGPNGSGKSNLMDAISFVLG-EKTSNLRVKTL 61
+K I +E FKSY R + F F AI G NGSGKSN++D+I F+LG S +R L
Sbjct: 3 IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNL 62
Query: 62 RDLIHGAPVGKPAANRAFVSMVYSE----------EGAEDRTFAR-VIVGGSSEYKINNK 110
+DL++ G+ +A VS+ + E ++ T R V++GG ++Y IN
Sbjct: 63 QDLVYKN--GQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
Query: 111 VVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDK 170
+ +G+ + +FL+ QG + + P E ++ EE + G EY K
Sbjct: 121 NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAA--GTRMYEYKK 178
Query: 171 RKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYH 230
+ A++ + KK + + E+E Q+LK+E L+ K+
Sbjct: 179 -----IAAQKTIE-----KKEAKLKEIKTILEEEITPTIQKLKEE---RSSYLEYQKVMR 225
Query: 231 NEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSE 290
EIE L++ + + +D K + +ELKE + ++ K+ E + +K+IK + E
Sbjct: 226 ---EIEHLSRLYIAYQFLLAEDTKV--RSAEELKEMQDKVIKLQEELSENDKKIKALNHE 280
Query: 291 LNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEF 350
+ + + K KE T ++ LE A L AQ+ K + D +K + E R+E
Sbjct: 281 IEELEKR--KDKE-TGGILRSLEDA---LAEAQRVNTKSQSAFDLKKKNLACEESKRKEL 334
Query: 351 EERMEEESQSQGRDLTLEENQVKKY----HRLKEEASKRAATLAQELEKFNRDQKADQDR 406
E+ M E+S++ L +E +VKK H L+E ++K A LA + FN
Sbjct: 335 EKNMVEDSKT----LAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSN 390
Query: 407 LDLEER-------------KKVETEAK-----IKQKLREIEENQKRIEKLEEYITTSKQS 448
D E K +TEAK +K +E++ Q ++K++ +++
Sbjct: 391 EDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEA 450
Query: 449 LEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIK 508
LE K+L+ +L E EM K +E NKE E L + R RQ S R E E++
Sbjct: 451 LEAVKRLKEKL--EAEMKKLNYEE-NKE-----ESLLEKR--RQLSRDIGRLKETYEALL 500
Query: 509 RLYPG---------------SVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTG 553
+P V G + L A+ V G+ + ++VD+E TG
Sbjct: 501 ARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTG 560
Query: 554 RDCIQYIKEQRGEPE---TFLPLDYLEVKP-TDEKLRELKG------AKLVIDVIRYEPP 603
+ ++ RGE + T +PL+ + + E LR + + + ++ Y+P
Sbjct: 561 KKLLE-----RGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKP- 614
Query: 604 HIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKA 663
++KA+++ G VCDN+++A+++AF +TV L G +F G +SGGA A
Sbjct: 615 ELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASI 674
Query: 664 RRWDEKAVD-----KLKEKKER-LTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQS 717
++ D ++KE + R L EEL K +L+Q Q +K ++
Sbjct: 675 LTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQ--------QWEMKTEEA 726
Query: 718 DLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVF 777
DL QTK + + + Q++ ++ +K+ I+ E +K+ KE + E++
Sbjct: 727 DLLQTKLQQSSYHKQQEE------------LDALKKTIEESEETLKNTKEIQRKAEEKY- 773
Query: 778 EEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHM 837
E+ ++ E E+ +R+ + A+K+L+ K D ++KE Q
Sbjct: 774 -----EVLENKMKNAEAER-ERELKDAQKKLDCAKTKA------DASSKKMKEKQ----- 816
Query: 838 WEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKK 897
Q V+ E+E+LK+E + + QL+ + + +S++ E+ + ++
Sbjct: 817 --QEVEAITLELEELKREHTSYKQ-------QLEAVNEAIKSYESQIEVMAAEVAKNKES 867
Query: 898 LGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSS 957
+ A +E+T ++ +TA +T ++ K ++ + +K+ K +IS+ + +
Sbjct: 868 VNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKI---KELDHNISKHKREA 924
Query: 958 QGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVL 1017
+ G+ ++S + I + + + +E QKL E + L
Sbjct: 925 E-----DGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKL 979
Query: 1018 QRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESV 1077
R NM+AM L +++ + + K E + +++ N ++ V
Sbjct: 980 GRNV--NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKV 1037
Query: 1078 ATNIDEIYKALSRNSSAQAFLGPENPE-EPYLDGINYNCVAPGKRFRP-MDNLSGGEKTV 1135
+ I+ L A A L P PE + LDG+ + VA G ++ + LSGG++++
Sbjct: 1038 NKDFGSIFSTLL--PGANAMLAP--PEGQTVLDGLEFK-VALGNTWKENLTELSGGQRSL 1092
Query: 1136 AALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYT 1195
AL+L+ ++ +KPAP ++LDE+DAALD ++ + ++ T + Q IV+SLKE +
Sbjct: 1093 VALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFT-HSQFIVVSLKEGMFN 1151
Query: 1196 KAESL 1200
A L
Sbjct: 1152 NANVL 1156
>gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens]
Length = 1217
Score = 232 bits (591), Expect = 2e-60
Identities = 291/1288 (22%), Positives = 557/1288 (43%), Gaps = 187/1288 (14%)
Query: 3 FLKLIEIENFKSYKGRQIIGPFQ-RFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTL 61
++K + I+ F+SY+ + I+ PF + I+G NGSGKSN AI FVL ++ S+LR +
Sbjct: 2 YIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQR 61
Query: 62 RDLIHGAPVGKPAANRAFVSMVYSEEG------AEDRTFARVIVGGSSEYKINNKVVQLH 115
L+H P AFV +++ E+ + RVI +Y ++ K+V +
Sbjct: 62 LALLHEGT--GPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKN 119
Query: 116 EYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEM 175
+ LE G ++V QG + +A +R L E++ + + YD+RK+E
Sbjct: 120 DVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGT----RVYDERKEES 175
Query: 176 VKAEEDTQFNYHR----KKNIAAERKEAKQEKEEADRYQR-------------------- 211
+ ++T+ + K I ++EKEE +YQ+
Sbjct: 176 ISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNET 235
Query: 212 --------------------LKD---------EVVRAQVQLQLFKLYHNEVEIEKLNKEL 242
L+D E + QV+ K+ + E E+L+ E
Sbjct: 236 RAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAER 295
Query: 243 ASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAK 302
+ K+ K + + ++DEL ++ ++++E+Q++ ++I+EK EL + P++ K
Sbjct: 296 QEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVK 355
Query: 303 ENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQG 362
E I +L A+ + + + K+ +G S +++E ++ +++E +S
Sbjct: 356 EKEERGIARL--AQATQERTDLYAKQGRG----------SQFTSKEERDKWIKKELKSLD 403
Query: 363 RDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNR-DQKADQDRLDLEERKKVETEAKI 421
+ + ++ Q+ H+ E+ A + LE++N+ DQ ++ + +EE + E K
Sbjct: 404 QAINDKKRQIAAIHKDLEDTE---ANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKN 460
Query: 422 KQKLREIEENQK-RIEKLEEY-ITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQ 479
K+ + E N R E E+ + ++ LE++++L T + + ID INK L+
Sbjct: 461 KKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAIL--NGIDSINKVLDH 518
Query: 480 VMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLG 539
R+ I + ++ Y G V C+P + V G
Sbjct: 519 F------------------RRKGINQHVQNGYHGIVMNNF--ECEPA---FYTCVEVTAG 555
Query: 540 KNMDAIIVDSEKTGRDCIQYIKEQRGEPE-TFLPLDYLEVKPTDEKLRELKGAKLVIDVI 598
+ IVDS++ + + E TFLPL+ L+V+ D E A +I +
Sbjct: 556 NRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVR--DTAYPETNDAIPMISKL 613
Query: 599 RYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASD 658
RY P KA ++ G L+C ++E + ++A + L+G G ++GG D
Sbjct: 614 RYN-PRFDKAFKHVFGKTLICRSMEVSTQLARAFTM--DCITLEGDQVSHRGALTGGYYD 670
Query: 659 LKAKARRWDEKAVDKLKEKKERLTEELKEQMK--AKRKEAELRQVQSQAHGLQMRLKYSQ 716
+ K+R +K V K +E+ L +L E ++ +R E+ Q+ +Q +++ Q
Sbjct: 671 TR-KSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQ----MQQIETQQ 725
Query: 717 SDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEV 776
+ ++ L+ K K + F P+ +R +QS E + ++ ++ E+
Sbjct: 726 RKFKASRDSILSEMKMLKEKRQQSEKTFMPK----QRSLQSLEASLHAMESTRESLKAEL 781
Query: 777 FEEFCREIGVRN----------IREFEEEKVKRQNEIAK-----KRLEF---ENQKTRLG 818
+ ++ + + IR+ ++E + NE K R+E EN + RL
Sbjct: 782 GTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLD 841
Query: 819 IQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHL 878
Q++ E N+L+E + + T +E+E + K + +TMA+ +DL N
Sbjct: 842 -QVEQELNELRETEGGTVLTATT-----SELEAINKR-------VKDTMARSEDLDNSID 888
Query: 879 AKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDI 938
++ + + ME + N E H+ + +TK +K ++R +L K + +
Sbjct: 889 KTEAGIKELQKSMERWK------NMEKEHM--DAINHDTKELEKMTNRQGMLLKKKEECM 940
Query: 939 KLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAE-E 997
K G++ + E+ ++S Q + ++ Y + + D
Sbjct: 941 KKIRELGSLPQEAFEK-----YQTLSLKQLFRKLEQCNTELK-KYSHVNKKALDQFVNFS 994
Query: 998 EIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQ 1057
E K+++ Q++L+ + + N+ + K E+++ F++ S F ++ +
Sbjct: 995 EQKEKLIKRQEELDRGYKSIMELM--NVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGK 1052
Query: 1058 AFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVA 1117
A +KK + + E + E R S +Q+ + P G+
Sbjct: 1053 ATLVMKKGDVEGSQSQDEGEGSGESE------RGSGSQSSV----PSVDQFTGVGIRVSF 1102
Query: 1118 PGKR--FRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIK 1175
GK+ R M LSGG+K++ ALAL+FAI PAPF++ DEID ALD + V++ I
Sbjct: 1103 TGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIM 1162
Query: 1176 EQSTCNFQAIVISLKEEFYTKAESLIGV 1203
E + + Q I + + E A+ GV
Sbjct: 1163 ELAV-HAQFITTTFRPELLESADKFYGV 1189
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 144 bits (364), Expect = 4e-34
Identities = 212/1049 (20%), Positives = 446/1049 (42%), Gaps = 136/1049 (12%)
Query: 114 LHEYSEELEKLGILIK--ARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKR 171
L ++EL+K+ L + AR QG V + +ER L E++ EL E ++
Sbjct: 879 LQARAQELQKVQELQQQSAREVGELQGRVAQLE----EERARLAEQLRAEAELCAEAEET 934
Query: 172 KKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHN 231
+ + +++ + + E +E ++ + + RL+ + + L+ +
Sbjct: 935 RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKK--RLQQHIQELEAHLEAEEGARQ 992
Query: 232 EVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSEL 291
++++EK+ E +K K+ E+D ++ +L +++K L + E E +EK L
Sbjct: 993 KLQLEKVTTE--AKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL 1050
Query: 292 NQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFE 351
N+ R +Y + +++K E K Q +K ++ G+ EL+++M+ ++ +E
Sbjct: 1051 NKLRLKYEATIADMEDRLRKEE---KGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR 1107
Query: 352 ERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQ----KADQDRL 407
++ + + L E++ +L + + A LA+ E ++ KA++ R
Sbjct: 1108 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1167
Query: 408 DLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLE----------- 456
DL E + +++ L Q+ K E+ +T K++LEE+ ++
Sbjct: 1168 DLGEELEA-LRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRH 1226
Query: 457 ----GELTEEVEMAKR--------------RIDEINKELN--QVMEQLGDARIDRQESSR 496
GEL E++E A+R + E+ EL+ Q Q G+ R R E
Sbjct: 1227 GQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQL 1286
Query: 497 QQ----------RKAEIMESIKRLYP--GSVYGRLIDLCQPT-QKKYQIAVTKVLGKNMD 543
Q+ +AE E ++R +V G L + T + +++ T+ +
Sbjct: 1287 QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQ 1346
Query: 544 AIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPP 603
++ + + ++ E E + REL+ A+ + R
Sbjct: 1347 ELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQE 1406
Query: 604 HIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKA 663
AL+ E+ARR A + AL L +K+ + +
Sbjct: 1407 EEAGALEAG----------EEARRRA-----AREAEALTQRLAEKTETVDRLERGRRRLQ 1451
Query: 664 RRWDEKAVD--------KLKEKKERLTEELKEQMKA---------KRKEAELRQVQSQAH 706
+ D+ +D EKK+R ++L + KA +R EAE R+ +++A
Sbjct: 1452 QELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1511
Query: 707 GLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLK 766
L L+ Q E+ + ++ AL + ++ L S+ + G +++++R + E+ DL+
Sbjct: 1512 SLTRALEEEQEAREELERQNRALRAELEALLSSK-DDVGKSVHELERACRVAEQAANDLR 1570
Query: 767 EKMNQVEDEVF----EEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLD 822
++ ++EDE+ + E+ V+ ++ E ++ ++E ++R + +L QL
Sbjct: 1571 AQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEER------RRQLAKQLR 1624
Query: 823 FEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKS 882
+ + E++ + + KK E E+E+LK + + +E + QL+ ++ Q
Sbjct: 1625 DAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWR 1684
Query: 883 EVNDKNHEMEEI-------RKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKM 935
EV + EEI K+L G E+ LQ+E+ A + Q + DR +
Sbjct: 1685 EVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVAN 1744
Query: 936 QDIKLPLSKGTMDDISQEEG-----SSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDL 990
++ +++ Q EG + E+ S S+ ++ Y R+ L++++ L +L
Sbjct: 1745 GNLS---KAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRY-RKLLLQVE--SLTTEL 1798
Query: 991 K-----DAQAE---EEIKQEMNTLQQKLNEQQSVLQ-----RIAAPNMKAMEKLESVRDK 1037
A+AE +++++++ L+ +L E+ + + IAA K + E + +
Sbjct: 1799 SAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQE 1858
Query: 1038 FQETSDEFEAARKRAKKAKQAFEQIKKER 1066
+E + R+ K+ K+ Q+++ER
Sbjct: 1859 TRERILSGKLVRRAEKRLKEVVLQVEEER 1887
Score = 101 bits (252), Expect = 4e-21
Identities = 177/937 (18%), Positives = 401/937 (42%), Gaps = 89/937 (9%)
Query: 160 RSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRA 219
R+G LAQ ++R ++ + F + +A + +Q+++ A R+ A
Sbjct: 796 RAGVLAQLEEER--DLKVTDIIVSFQAAARGYLARRAFQKRQQQQSA---LRVMQRNCAA 850
Query: 220 QVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQ 279
++L+ ++ + +++ L ++ +++ ++ + + KV++ ++ +E+G++ Q
Sbjct: 851 YLKLRHWQWWRLFTKVKPL-LQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQ 909
Query: 280 IEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKE 339
+E+E +L + +A+E +L A K+ L+ + R G+ +E ++
Sbjct: 910 LEEERARLAEQLRAEAELCAEAEETRG----RLAARKQELELVVSELEARVGEEEECSRQ 965
Query: 340 MLSVEKARQEFEERMEEESQS-QGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNR 398
M + +K Q+ + +E ++ +G L+ +V ++K + + L + K ++
Sbjct: 966 MQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMK-KFEEDLLLLEDQNSKLSK 1024
Query: 399 DQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGE 458
++K +DRL A+ + E EE K + KL + +E++ + E +
Sbjct: 1025 ERKLLEDRL-----------AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEK 1073
Query: 459 LTEEVEMAKRRIDEINKEL-NQVMEQLGDARIDRQESSRQQRKAEIMESIKRLY-PGSVY 516
+E+E KRR+D + EL Q++EQ R + + +++ E+ ++ R G
Sbjct: 1074 GRQELEKLKRRLDGESSELQEQMVEQ--QQRAEELRAQLGRKEEELQAALARAEDEGGAR 1131
Query: 517 GRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYL 576
+L+ + Q A + + + +EK RD + ++ RGE E L
Sbjct: 1132 AQLLKSLREAQAALAEAQEDLESERVAR--TKAEKQRRDLGEELEALRGELEDTLDSTNA 1189
Query: 577 EVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNAL--VCDNVEDARRIAFGGHQ 634
+ + ++ +E+ K ++ + L+ G AL + + +E ARR G
Sbjct: 1190 QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARR---GKGA 1246
Query: 635 RHKT-VALDGTLFQKSGVISG---GASDLKAKARRWD-------------EKAVDKLKEK 677
KT +AL+ + + +S + + + RR + E+A + EK
Sbjct: 1247 WEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1306
Query: 678 KERLTEELKEQMKAKRKEAELRQVQ--SQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKS 735
+R EL E + EAE + ++ + + +L +Q L++ LAL + ++
Sbjct: 1307 LQRAQAEL-ENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRA 1365
Query: 736 KLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEE 795
+E+E A ++ + + RE++ + ++++ E E G E
Sbjct: 1366 -MEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEE----EAGALEAGEEARR 1420
Query: 796 KVKRQNEIAKKRL--------EFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDEN 847
+ R+ E +RL E + RL +LD L++ + V T++K +
Sbjct: 1421 RAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLV----STLEKKQR 1476
Query: 848 EIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTH 907
+ ++L EE+ + E + + + A+ + E +E R++L N+
Sbjct: 1477 KFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRA--- 1533
Query: 908 LQKEVTAIETKLEQKRSDRHNLLQACKM-----QDIKLPLSKGTMDDISQEEGSSQGEDS 962
L+ E+ A+ + + H L +AC++ D++ +++ + + E+ + E +
Sbjct: 1534 LRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT 1593
Query: 963 VSG--SQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNT--------LQQKLNE 1012
V +Q + R+ E L + L+DA+ E + +++ T L+ +L E
Sbjct: 1594 VQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1653
Query: 1013 QQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAAR 1049
++ + +A+++L ++ + +E E E R
Sbjct: 1654 LKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1690
Score = 93.6 bits (231), Expect = 1e-18
Identities = 155/843 (18%), Positives = 353/843 (41%), Gaps = 113/843 (13%)
Query: 150 ERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRY 209
ER A + + +L +E + + E+ + T A + +K+E+E +
Sbjct: 1155 ERVARTKAEKQRRDLGEELEALRGELEDTLDSTN---------AQQELRSKREQEVTELK 1205
Query: 210 QRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDK----VEDELKE 265
+ L++E + +Q + H + ELA + ++ + K +K +E E+ E
Sbjct: 1206 KTLEEETRIHEAAVQELRQRHGQAL-----GELAEQLEQARRGKGAWEKTRLALEAEVSE 1260
Query: 266 KKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKH 325
+ EL + +Q+ E+ + + +L + + + + + +KL+ A+ L+N
Sbjct: 1261 LRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGA 1320
Query: 326 YKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQ----GRDLTLEENQVKKYHRLKEE 381
+ + L KE+ S E + +E ++EE++++ R +E +L+EE
Sbjct: 1321 LNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1380
Query: 382 ASKR------AATLAQELEKFNRDQKADQDRLDL--EERKKVETEAK-IKQKLREIEENQ 432
A+ R T +L ++ R Q+ + L+ E R++ EA+ + Q+L E E
Sbjct: 1381 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETV 1440
Query: 433 KRIE----KLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDAR 488
R+E +L++ + + LE+Q+ +L +E +R+ D++ E + + + R
Sbjct: 1441 DRLERGRRRLQQELDDATMDLEQQR----QLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1496
Query: 489 IDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVD 548
+R E+ ++R+A + R ++ Q +++ + + L ++A++
Sbjct: 1497 -ERAEAEGREREARALS----------LTRALEEEQEAREELE-RQNRALRAELEALLSS 1544
Query: 549 SEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDV-IRYEPPHIKK 607
+ G+ + + R + L +V +++L + AKL ++V ++ ++
Sbjct: 1545 KDDVGKSVHELERACRVAEQAANDL-RAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1603
Query: 608 ALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVIS------GGASDLKA 661
LQ D + RR R V D Q++ ++ G +LKA
Sbjct: 1604 DLQGR-------DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKA 1656
Query: 662 K---ARRWDEKAVDKLKEKKERL---------TEELKEQMKAKRKEAELRQVQSQAHGLQ 709
+ A + E+AV +L++ + ++ T +E++ ++ +E+E R +A L+
Sbjct: 1657 QMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLR 1716
Query: 710 MRLKYSQSDLEQTKTRH---------------LALNLQEKSKLESELANFGPRINDIKRI 754
++ + + SD + + + A L+EK +LE L + +
Sbjct: 1717 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEE---- 1772
Query: 755 IQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQK 814
QS + D K+ + + E E E ++++RQ + + RL E+
Sbjct: 1773 EQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAG 1832
Query: 815 TR---------LGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDE 865
R L +L + QL+++ + + + V++ E ++++ + + ++ D+
Sbjct: 1833 ARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQ 1892
Query: 866 TMAQLQ-------DLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETK 918
QL+ LK Q + E + ++++L + + +EVT + +
Sbjct: 1893 LRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNR 1952
Query: 919 LEQ 921
L +
Sbjct: 1953 LRR 1955
Score = 47.8 bits (112), Expect = 7e-05
Identities = 60/312 (19%), Positives = 131/312 (41%), Gaps = 36/312 (11%)
Query: 773 EDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQ 832
+DEV + +E+ + ++E +++ + E+ + + E ++ RL QL E E +
Sbjct: 875 QDEVLQARAQEL--QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAE 932
Query: 833 DKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEME 892
+ + K+E + + ++ + + ++ Q +K + E+E
Sbjct: 933 ET-----------RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE 981
Query: 893 EIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQ 952
+ GA ++ LQ E E K+++ D L + Q+ KL + ++D
Sbjct: 982 AHLEAEEGARQK---LQLEKVTTEAKMKKFEED----LLLLEDQNSKLSKERKLLEDRLA 1034
Query: 953 EEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDL----KDAQAEEEIKQ----EMN 1004
E S E+ +++ S+ E D+ + L K Q E++K+ E +
Sbjct: 1035 EFSSQAAEEE----EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS 1090
Query: 1005 TLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAK----QAFE 1060
LQ+++ EQQ + + A + E+L++ + ++ K ++A+ +A E
Sbjct: 1091 ELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQE 1150
Query: 1061 QIKKERFDRFNA 1072
++ ER R A
Sbjct: 1151 DLESERVARTKA 1162
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 144 bits (364), Expect = 4e-34
Identities = 212/1049 (20%), Positives = 446/1049 (42%), Gaps = 136/1049 (12%)
Query: 114 LHEYSEELEKLGILIK--ARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKR 171
L ++EL+K+ L + AR QG V + +ER L E++ EL E ++
Sbjct: 871 LQARAQELQKVQELQQQSAREVGELQGRVAQLE----EERARLAEQLRAEAELCAEAEET 926
Query: 172 KKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHN 231
+ + +++ + + E +E ++ + + RL+ + + L+ +
Sbjct: 927 RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKK--RLQQHIQELEAHLEAEEGARQ 984
Query: 232 EVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSEL 291
++++EK+ E +K K+ E+D ++ +L +++K L + E E +EK L
Sbjct: 985 KLQLEKVTTE--AKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL 1042
Query: 292 NQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFE 351
N+ R +Y + +++K E K Q +K ++ G+ EL+++M+ ++ +E
Sbjct: 1043 NKLRLKYEATIADMEDRLRKEE---KGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR 1099
Query: 352 ERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQ----KADQDRL 407
++ + + L E++ +L + + A LA+ E ++ KA++ R
Sbjct: 1100 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1159
Query: 408 DLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLE----------- 456
DL E + +++ L Q+ K E+ +T K++LEE+ ++
Sbjct: 1160 DLGEELEA-LRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRH 1218
Query: 457 ----GELTEEVEMAKR--------------RIDEINKELN--QVMEQLGDARIDRQESSR 496
GEL E++E A+R + E+ EL+ Q Q G+ R R E
Sbjct: 1219 GQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQL 1278
Query: 497 QQ----------RKAEIMESIKRLYP--GSVYGRLIDLCQPT-QKKYQIAVTKVLGKNMD 543
Q+ +AE E ++R +V G L + T + +++ T+ +
Sbjct: 1279 QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQ 1338
Query: 544 AIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPP 603
++ + + ++ E E + REL+ A+ + R
Sbjct: 1339 ELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQE 1398
Query: 604 HIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKA 663
AL+ E+ARR A + AL L +K+ + +
Sbjct: 1399 EEAGALEAG----------EEARRRA-----AREAEALTQRLAEKTETVDRLERGRRRLQ 1443
Query: 664 RRWDEKAVD--------KLKEKKERLTEELKEQMKA---------KRKEAELRQVQSQAH 706
+ D+ +D EKK+R ++L + KA +R EAE R+ +++A
Sbjct: 1444 QELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1503
Query: 707 GLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLK 766
L L+ Q E+ + ++ AL + ++ L S+ + G +++++R + E+ DL+
Sbjct: 1504 SLTRALEEEQEAREELERQNRALRAELEALLSSK-DDVGKSVHELERACRVAEQAANDLR 1562
Query: 767 EKMNQVEDEVF----EEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLD 822
++ ++EDE+ + E+ V+ ++ E ++ ++E ++R + +L QL
Sbjct: 1563 AQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEER------RRQLAKQLR 1616
Query: 823 FEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKS 882
+ + E++ + + KK E E+E+LK + + +E + QL+ ++ Q
Sbjct: 1617 DAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWR 1676
Query: 883 EVNDKNHEMEEI-------RKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKM 935
EV + EEI K+L G E+ LQ+E+ A + Q + DR +
Sbjct: 1677 EVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVAN 1736
Query: 936 QDIKLPLSKGTMDDISQEEG-----SSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDL 990
++ +++ Q EG + E+ S S+ ++ Y R+ L++++ L +L
Sbjct: 1737 GNLS---KAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRY-RKLLLQVE--SLTTEL 1790
Query: 991 K-----DAQAE---EEIKQEMNTLQQKLNEQQSVLQ-----RIAAPNMKAMEKLESVRDK 1037
A+AE +++++++ L+ +L E+ + + IAA K + E + +
Sbjct: 1791 SAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQE 1850
Query: 1038 FQETSDEFEAARKRAKKAKQAFEQIKKER 1066
+E + R+ K+ K+ Q+++ER
Sbjct: 1851 TRERILSGKLVRRAEKRLKEVVLQVEEER 1879
Score = 101 bits (252), Expect = 4e-21
Identities = 177/937 (18%), Positives = 401/937 (42%), Gaps = 89/937 (9%)
Query: 160 RSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRA 219
R+G LAQ ++R ++ + F + +A + +Q+++ A R+ A
Sbjct: 788 RAGVLAQLEEER--DLKVTDIIVSFQAAARGYLARRAFQKRQQQQSA---LRVMQRNCAA 842
Query: 220 QVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQ 279
++L+ ++ + +++ L ++ +++ ++ + + KV++ ++ +E+G++ Q
Sbjct: 843 YLKLRHWQWWRLFTKVKPL-LQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQ 901
Query: 280 IEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKE 339
+E+E +L + +A+E +L A K+ L+ + R G+ +E ++
Sbjct: 902 LEEERARLAEQLRAEAELCAEAEETRG----RLAARKQELELVVSELEARVGEEEECSRQ 957
Query: 340 MLSVEKARQEFEERMEEESQS-QGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNR 398
M + +K Q+ + +E ++ +G L+ +V ++K + + L + K ++
Sbjct: 958 MQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMK-KFEEDLLLLEDQNSKLSK 1016
Query: 399 DQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGE 458
++K +DRL A+ + E EE K + KL + +E++ + E +
Sbjct: 1017 ERKLLEDRL-----------AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEK 1065
Query: 459 LTEEVEMAKRRIDEINKEL-NQVMEQLGDARIDRQESSRQQRKAEIMESIKRLY-PGSVY 516
+E+E KRR+D + EL Q++EQ R + + +++ E+ ++ R G
Sbjct: 1066 GRQELEKLKRRLDGESSELQEQMVEQ--QQRAEELRAQLGRKEEELQAALARAEDEGGAR 1123
Query: 517 GRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYL 576
+L+ + Q A + + + +EK RD + ++ RGE E L
Sbjct: 1124 AQLLKSLREAQAALAEAQEDLESERVAR--TKAEKQRRDLGEELEALRGELEDTLDSTNA 1181
Query: 577 EVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNAL--VCDNVEDARRIAFGGHQ 634
+ + ++ +E+ K ++ + L+ G AL + + +E ARR G
Sbjct: 1182 QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARR---GKGA 1238
Query: 635 RHKT-VALDGTLFQKSGVISG---GASDLKAKARRWD-------------EKAVDKLKEK 677
KT +AL+ + + +S + + + RR + E+A + EK
Sbjct: 1239 WEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1298
Query: 678 KERLTEELKEQMKAKRKEAELRQVQ--SQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKS 735
+R EL E + EAE + ++ + + +L +Q L++ LAL + ++
Sbjct: 1299 LQRAQAEL-ENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRA 1357
Query: 736 KLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEE 795
+E+E A ++ + + RE++ + ++++ E E G E
Sbjct: 1358 -MEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEE----EAGALEAGEEARR 1412
Query: 796 KVKRQNEIAKKRL--------EFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDEN 847
+ R+ E +RL E + RL +LD L++ + V T++K +
Sbjct: 1413 RAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLV----STLEKKQR 1468
Query: 848 EIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTH 907
+ ++L EE+ + E + + + A+ + E +E R++L N+
Sbjct: 1469 KFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRA--- 1525
Query: 908 LQKEVTAIETKLEQKRSDRHNLLQACKM-----QDIKLPLSKGTMDDISQEEGSSQGEDS 962
L+ E+ A+ + + H L +AC++ D++ +++ + + E+ + E +
Sbjct: 1526 LRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT 1585
Query: 963 VSG--SQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNT--------LQQKLNE 1012
V +Q + R+ E L + L+DA+ E + +++ T L+ +L E
Sbjct: 1586 VQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1645
Query: 1013 QQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAAR 1049
++ + +A+++L ++ + +E E E R
Sbjct: 1646 LKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1682
Score = 93.6 bits (231), Expect = 1e-18
Identities = 155/843 (18%), Positives = 353/843 (41%), Gaps = 113/843 (13%)
Query: 150 ERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRY 209
ER A + + +L +E + + E+ + T A + +K+E+E +
Sbjct: 1147 ERVARTKAEKQRRDLGEELEALRGELEDTLDSTN---------AQQELRSKREQEVTELK 1197
Query: 210 QRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDK----VEDELKE 265
+ L++E + +Q + H + ELA + ++ + K +K +E E+ E
Sbjct: 1198 KTLEEETRIHEAAVQELRQRHGQAL-----GELAEQLEQARRGKGAWEKTRLALEAEVSE 1252
Query: 266 KKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKH 325
+ EL + +Q+ E+ + + +L + + + + + +KL+ A+ L+N
Sbjct: 1253 LRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGA 1312
Query: 326 YKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQ----GRDLTLEENQVKKYHRLKEE 381
+ + L KE+ S E + +E ++EE++++ R +E +L+EE
Sbjct: 1313 LNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1372
Query: 382 ASKR------AATLAQELEKFNRDQKADQDRLDL--EERKKVETEAK-IKQKLREIEENQ 432
A+ R T +L ++ R Q+ + L+ E R++ EA+ + Q+L E E
Sbjct: 1373 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETV 1432
Query: 433 KRIE----KLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDAR 488
R+E +L++ + + LE+Q+ +L +E +R+ D++ E + + + R
Sbjct: 1433 DRLERGRRRLQQELDDATMDLEQQR----QLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1488
Query: 489 IDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVD 548
+R E+ ++R+A + R ++ Q +++ + + L ++A++
Sbjct: 1489 -ERAEAEGREREARALS----------LTRALEEEQEAREELE-RQNRALRAELEALLSS 1536
Query: 549 SEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDV-IRYEPPHIKK 607
+ G+ + + R + L +V +++L + AKL ++V ++ ++
Sbjct: 1537 KDDVGKSVHELERACRVAEQAANDL-RAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1595
Query: 608 ALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVIS------GGASDLKA 661
LQ D + RR R V D Q++ ++ G +LKA
Sbjct: 1596 DLQGR-------DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKA 1648
Query: 662 K---ARRWDEKAVDKLKEKKERL---------TEELKEQMKAKRKEAELRQVQSQAHGLQ 709
+ A + E+AV +L++ + ++ T +E++ ++ +E+E R +A L+
Sbjct: 1649 QMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLR 1708
Query: 710 MRLKYSQSDLEQTKTRH---------------LALNLQEKSKLESELANFGPRINDIKRI 754
++ + + SD + + + A L+EK +LE L + +
Sbjct: 1709 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEE---- 1764
Query: 755 IQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQK 814
QS + D K+ + + E E E ++++RQ + + RL E+
Sbjct: 1765 EQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAG 1824
Query: 815 TR---------LGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDE 865
R L +L + QL+++ + + + V++ E ++++ + + ++ D+
Sbjct: 1825 ARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQ 1884
Query: 866 TMAQLQ-------DLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETK 918
QL+ LK Q + E + ++++L + + +EVT + +
Sbjct: 1885 LRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNR 1944
Query: 919 LEQ 921
L +
Sbjct: 1945 LRR 1947
Score = 47.8 bits (112), Expect = 7e-05
Identities = 60/312 (19%), Positives = 131/312 (41%), Gaps = 36/312 (11%)
Query: 773 EDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQ 832
+DEV + +E+ + ++E +++ + E+ + + E ++ RL QL E E +
Sbjct: 867 QDEVLQARAQEL--QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAE 924
Query: 833 DKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEME 892
+ + K+E + + ++ + + ++ Q +K + E+E
Sbjct: 925 ET-----------RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE 973
Query: 893 EIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQ 952
+ GA ++ LQ E E K+++ D L + Q+ KL + ++D
Sbjct: 974 AHLEAEEGARQK---LQLEKVTTEAKMKKFEED----LLLLEDQNSKLSKERKLLEDRLA 1026
Query: 953 EEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDL----KDAQAEEEIKQ----EMN 1004
E S E+ +++ S+ E D+ + L K Q E++K+ E +
Sbjct: 1027 EFSSQAAEEE----EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS 1082
Query: 1005 TLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAK----QAFE 1060
LQ+++ EQQ + + A + E+L++ + ++ K ++A+ +A E
Sbjct: 1083 ELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQE 1142
Query: 1061 QIKKERFDRFNA 1072
++ ER R A
Sbjct: 1143 DLESERVARTKA 1154
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 144 bits (364), Expect = 4e-34
Identities = 212/1049 (20%), Positives = 446/1049 (42%), Gaps = 136/1049 (12%)
Query: 114 LHEYSEELEKLGILIK--ARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKR 171
L ++EL+K+ L + AR QG V + +ER L E++ EL E ++
Sbjct: 912 LQARAQELQKVQELQQQSAREVGELQGRVAQLE----EERARLAEQLRAEAELCAEAEET 967
Query: 172 KKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHN 231
+ + +++ + + E +E ++ + + RL+ + + L+ +
Sbjct: 968 RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKK--RLQQHIQELEAHLEAEEGARQ 1025
Query: 232 EVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSEL 291
++++EK+ E +K K+ E+D ++ +L +++K L + E E +EK L
Sbjct: 1026 KLQLEKVTTE--AKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL 1083
Query: 292 NQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFE 351
N+ R +Y + +++K E K Q +K ++ G+ EL+++M+ ++ +E
Sbjct: 1084 NKLRLKYEATIADMEDRLRKEE---KGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR 1140
Query: 352 ERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQ----KADQDRL 407
++ + + L E++ +L + + A LA+ E ++ KA++ R
Sbjct: 1141 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1200
Query: 408 DLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLE----------- 456
DL E + +++ L Q+ K E+ +T K++LEE+ ++
Sbjct: 1201 DLGEELEA-LRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRH 1259
Query: 457 ----GELTEEVEMAKR--------------RIDEINKELN--QVMEQLGDARIDRQESSR 496
GEL E++E A+R + E+ EL+ Q Q G+ R R E
Sbjct: 1260 GQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQL 1319
Query: 497 QQ----------RKAEIMESIKRLYP--GSVYGRLIDLCQPT-QKKYQIAVTKVLGKNMD 543
Q+ +AE E ++R +V G L + T + +++ T+ +
Sbjct: 1320 QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQ 1379
Query: 544 AIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPP 603
++ + + ++ E E + REL+ A+ + R
Sbjct: 1380 ELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQE 1439
Query: 604 HIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKA 663
AL+ E+ARR A + AL L +K+ + +
Sbjct: 1440 EEAGALEAG----------EEARRRA-----AREAEALTQRLAEKTETVDRLERGRRRLQ 1484
Query: 664 RRWDEKAVD--------KLKEKKERLTEELKEQMKA---------KRKEAELRQVQSQAH 706
+ D+ +D EKK+R ++L + KA +R EAE R+ +++A
Sbjct: 1485 QELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1544
Query: 707 GLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLK 766
L L+ Q E+ + ++ AL + ++ L S+ + G +++++R + E+ DL+
Sbjct: 1545 SLTRALEEEQEAREELERQNRALRAELEALLSSK-DDVGKSVHELERACRVAEQAANDLR 1603
Query: 767 EKMNQVEDEVF----EEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLD 822
++ ++EDE+ + E+ V+ ++ E ++ ++E ++R + +L QL
Sbjct: 1604 AQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEER------RRQLAKQLR 1657
Query: 823 FEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKS 882
+ + E++ + + KK E E+E+LK + + +E + QL+ ++ Q
Sbjct: 1658 DAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWR 1717
Query: 883 EVNDKNHEMEEI-------RKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKM 935
EV + EEI K+L G E+ LQ+E+ A + Q + DR +
Sbjct: 1718 EVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVAN 1777
Query: 936 QDIKLPLSKGTMDDISQEEG-----SSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDL 990
++ +++ Q EG + E+ S S+ ++ Y R+ L++++ L +L
Sbjct: 1778 GNLS---KAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRY-RKLLLQVE--SLTTEL 1831
Query: 991 K-----DAQAE---EEIKQEMNTLQQKLNEQQSVLQ-----RIAAPNMKAMEKLESVRDK 1037
A+AE +++++++ L+ +L E+ + + IAA K + E + +
Sbjct: 1832 SAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQE 1891
Query: 1038 FQETSDEFEAARKRAKKAKQAFEQIKKER 1066
+E + R+ K+ K+ Q+++ER
Sbjct: 1892 TRERILSGKLVRRAEKRLKEVVLQVEEER 1920
Score = 101 bits (252), Expect = 4e-21
Identities = 177/937 (18%), Positives = 401/937 (42%), Gaps = 89/937 (9%)
Query: 160 RSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRA 219
R+G LAQ ++R ++ + F + +A + +Q+++ A R+ A
Sbjct: 829 RAGVLAQLEEER--DLKVTDIIVSFQAAARGYLARRAFQKRQQQQSA---LRVMQRNCAA 883
Query: 220 QVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQ 279
++L+ ++ + +++ L ++ +++ ++ + + KV++ ++ +E+G++ Q
Sbjct: 884 YLKLRHWQWWRLFTKVKPL-LQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQ 942
Query: 280 IEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKE 339
+E+E +L + +A+E +L A K+ L+ + R G+ +E ++
Sbjct: 943 LEEERARLAEQLRAEAELCAEAEETRG----RLAARKQELELVVSELEARVGEEEECSRQ 998
Query: 340 MLSVEKARQEFEERMEEESQS-QGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNR 398
M + +K Q+ + +E ++ +G L+ +V ++K + + L + K ++
Sbjct: 999 MQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMK-KFEEDLLLLEDQNSKLSK 1057
Query: 399 DQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGE 458
++K +DRL A+ + E EE K + KL + +E++ + E +
Sbjct: 1058 ERKLLEDRL-----------AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEK 1106
Query: 459 LTEEVEMAKRRIDEINKEL-NQVMEQLGDARIDRQESSRQQRKAEIMESIKRLY-PGSVY 516
+E+E KRR+D + EL Q++EQ R + + +++ E+ ++ R G
Sbjct: 1107 GRQELEKLKRRLDGESSELQEQMVEQ--QQRAEELRAQLGRKEEELQAALARAEDEGGAR 1164
Query: 517 GRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYL 576
+L+ + Q A + + + +EK RD + ++ RGE E L
Sbjct: 1165 AQLLKSLREAQAALAEAQEDLESERVAR--TKAEKQRRDLGEELEALRGELEDTLDSTNA 1222
Query: 577 EVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNAL--VCDNVEDARRIAFGGHQ 634
+ + ++ +E+ K ++ + L+ G AL + + +E ARR G
Sbjct: 1223 QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARR---GKGA 1279
Query: 635 RHKT-VALDGTLFQKSGVISG---GASDLKAKARRWD-------------EKAVDKLKEK 677
KT +AL+ + + +S + + + RR + E+A + EK
Sbjct: 1280 WEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1339
Query: 678 KERLTEELKEQMKAKRKEAELRQVQ--SQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKS 735
+R EL E + EAE + ++ + + +L +Q L++ LAL + ++
Sbjct: 1340 LQRAQAEL-ENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRA 1398
Query: 736 KLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEE 795
+E+E A ++ + + RE++ + ++++ E E G E
Sbjct: 1399 -MEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEE----EAGALEAGEEARR 1453
Query: 796 KVKRQNEIAKKRL--------EFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDEN 847
+ R+ E +RL E + RL +LD L++ + V T++K +
Sbjct: 1454 RAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLV----STLEKKQR 1509
Query: 848 EIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTH 907
+ ++L EE+ + E + + + A+ + E +E R++L N+
Sbjct: 1510 KFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRA--- 1566
Query: 908 LQKEVTAIETKLEQKRSDRHNLLQACKM-----QDIKLPLSKGTMDDISQEEGSSQGEDS 962
L+ E+ A+ + + H L +AC++ D++ +++ + + E+ + E +
Sbjct: 1567 LRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT 1626
Query: 963 VSG--SQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNT--------LQQKLNE 1012
V +Q + R+ E L + L+DA+ E + +++ T L+ +L E
Sbjct: 1627 VQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1686
Query: 1013 QQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAAR 1049
++ + +A+++L ++ + +E E E R
Sbjct: 1687 LKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1723
Score = 93.6 bits (231), Expect = 1e-18
Identities = 155/843 (18%), Positives = 353/843 (41%), Gaps = 113/843 (13%)
Query: 150 ERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRY 209
ER A + + +L +E + + E+ + T A + +K+E+E +
Sbjct: 1188 ERVARTKAEKQRRDLGEELEALRGELEDTLDSTN---------AQQELRSKREQEVTELK 1238
Query: 210 QRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDK----VEDELKE 265
+ L++E + +Q + H + ELA + ++ + K +K +E E+ E
Sbjct: 1239 KTLEEETRIHEAAVQELRQRHGQAL-----GELAEQLEQARRGKGAWEKTRLALEAEVSE 1293
Query: 266 KKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKH 325
+ EL + +Q+ E+ + + +L + + + + + +KL+ A+ L+N
Sbjct: 1294 LRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGA 1353
Query: 326 YKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQ----GRDLTLEENQVKKYHRLKEE 381
+ + L KE+ S E + +E ++EE++++ R +E +L+EE
Sbjct: 1354 LNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1413
Query: 382 ASKR------AATLAQELEKFNRDQKADQDRLDL--EERKKVETEAK-IKQKLREIEENQ 432
A+ R T +L ++ R Q+ + L+ E R++ EA+ + Q+L E E
Sbjct: 1414 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETV 1473
Query: 433 KRIE----KLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDAR 488
R+E +L++ + + LE+Q+ +L +E +R+ D++ E + + + R
Sbjct: 1474 DRLERGRRRLQQELDDATMDLEQQR----QLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1529
Query: 489 IDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVD 548
+R E+ ++R+A + R ++ Q +++ + + L ++A++
Sbjct: 1530 -ERAEAEGREREARALS----------LTRALEEEQEAREELE-RQNRALRAELEALLSS 1577
Query: 549 SEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDV-IRYEPPHIKK 607
+ G+ + + R + L +V +++L + AKL ++V ++ ++
Sbjct: 1578 KDDVGKSVHELERACRVAEQAANDL-RAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1636
Query: 608 ALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVIS------GGASDLKA 661
LQ D + RR R V D Q++ ++ G +LKA
Sbjct: 1637 DLQGR-------DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKA 1689
Query: 662 K---ARRWDEKAVDKLKEKKERL---------TEELKEQMKAKRKEAELRQVQSQAHGLQ 709
+ A + E+AV +L++ + ++ T +E++ ++ +E+E R +A L+
Sbjct: 1690 QMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLR 1749
Query: 710 MRLKYSQSDLEQTKTRH---------------LALNLQEKSKLESELANFGPRINDIKRI 754
++ + + SD + + + A L+EK +LE L + +
Sbjct: 1750 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEE---- 1805
Query: 755 IQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQK 814
QS + D K+ + + E E E ++++RQ + + RL E+
Sbjct: 1806 EQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAG 1865
Query: 815 TR---------LGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDE 865
R L +L + QL+++ + + + V++ E ++++ + + ++ D+
Sbjct: 1866 ARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQ 1925
Query: 866 TMAQLQ-------DLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETK 918
QL+ LK Q + E + ++++L + + +EVT + +
Sbjct: 1926 LRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNR 1985
Query: 919 LEQ 921
L +
Sbjct: 1986 LRR 1988
Score = 47.8 bits (112), Expect = 7e-05
Identities = 60/312 (19%), Positives = 131/312 (41%), Gaps = 36/312 (11%)
Query: 773 EDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQ 832
+DEV + +E+ + ++E +++ + E+ + + E ++ RL QL E E +
Sbjct: 908 QDEVLQARAQEL--QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAE 965
Query: 833 DKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEME 892
+ + K+E + + ++ + + ++ Q +K + E+E
Sbjct: 966 ET-----------RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE 1014
Query: 893 EIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQ 952
+ GA ++ LQ E E K+++ D L + Q+ KL + ++D
Sbjct: 1015 AHLEAEEGARQK---LQLEKVTTEAKMKKFEED----LLLLEDQNSKLSKERKLLEDRLA 1067
Query: 953 EEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDL----KDAQAEEEIKQ----EMN 1004
E S E+ +++ S+ E D+ + L K Q E++K+ E +
Sbjct: 1068 EFSSQAAEEE----EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS 1123
Query: 1005 TLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAK----QAFE 1060
LQ+++ EQQ + + A + E+L++ + ++ K ++A+ +A E
Sbjct: 1124 ELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQE 1183
Query: 1061 QIKKERFDRFNA 1072
++ ER R A
Sbjct: 1184 DLESERVARTKA 1195
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 139 bits (351), Expect = 1e-32
Identities = 206/955 (21%), Positives = 418/955 (43%), Gaps = 140/955 (14%)
Query: 167 EYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLF 226
+ ++++EM+ EE+ R+K +AAE + + E ++ +L E ++ Q QLQ
Sbjct: 839 QVSRQEEEMMAKEEELV--KVREKQLAAENRLTEMETLQS----QLMAEKLQLQEQLQA- 891
Query: 227 KLYHNEV--EIEKLNKELASKNKEIEKD----KKRMDKVEDELKEKKKELGKMMREQQQI 280
E+ E E+L L +K +E+E+ + R+++ E+ + + E KM + Q++
Sbjct: 892 ---ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQEL 948
Query: 281 EKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEM 340
E++++E++S R + K T K+KKLE + L++ +L KE
Sbjct: 949 EEQLEEEESA----RQKLQLEKVTTEAKLKKLEEEQIILEDQN----------CKLAKEK 994
Query: 341 LSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQ 400
+E EF + EE + + + L +N+ + EE +R QELEK R
Sbjct: 995 KLLEDRIAEFTTNLTEE-EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR-- 1051
Query: 401 KADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELT 460
K + D DL + +I + +I E + ++ K EE + + +EE+
Sbjct: 1052 KLEGDSTDLSD--------QIAELQAQIAELKMQLAKKEEELQAALARVEEE-------A 1096
Query: 461 EEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRK-AEIMESIKRLYPGSVYGRL 519
+ MA ++I E+ +++++ E L R R ++ +Q+R E +E++K ++
Sbjct: 1097 AQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTA 1156
Query: 520 IDLCQPTQKKYQIAVTKVL----GKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDY 575
++++ ++ + K K +A I + + ++ + EQ E + +
Sbjct: 1157 AQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQL-EQTKRVKANL 1215
Query: 576 LEVKPTDEKLR-ELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQ 634
+ K T E R EL V+ + + H +K ++ V N + R
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275
Query: 635 RHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVD-KLKEKKERLTEELKEQMKAKR 693
V LD +G++S SD K+ D A++ +L++ +E L EE ++++
Sbjct: 1276 TKLQVELDNV----TGLLS--QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLST 1329
Query: 694 KEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKR 753
K L+QV+ + + + +L+ E+ + +H LE ++A ++ D+K+
Sbjct: 1330 K---LKQVEDEKNSFREQLE------EEEEAKH---------NLEKQIATLHAQVADMKK 1371
Query: 754 IIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQ 813
++ ++ +E +++ + + + + EEKV +++ K + + +
Sbjct: 1372 KMEDSVGCLETAEEVKRKLQKD----------LEGLSQRHEEKVAAYDKLEKTKTRLQQE 1421
Query: 814 KTRLGIQLD--------FEKNQLKEDQ----DKVHMWEQTVKKDENEIEKLKKEEQ--RH 859
L + LD EK Q K DQ +K + ++D E E +KE +
Sbjct: 1422 LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSL 1481
Query: 860 MKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKL 919
+ ++E M Q +L+ + ++E+ D +++ K + K L+++V ++T+L
Sbjct: 1482 ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL 1541
Query: 920 EQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVS--------------- 964
E+ + LQA +D KL L +Q E QG D S
Sbjct: 1542 EELEDE----LQA--TEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREME 1595
Query: 965 ------GSQRISSIYAREALIEIDYGDLCEDLKDA--QAEEEIKQ------EMNTLQQKL 1010
QR ++ AR+ L E+D DL + A +E IKQ +M ++L
Sbjct: 1596 AELEDERKQRSMAVAARKKL-EMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMREL 1654
Query: 1011 NEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKE 1065
++ ++ + I A + +KL+S+ + + +E AA + ++A+Q +++ E
Sbjct: 1655 DDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADE 1709
Score = 124 bits (310), Expect = 7e-28
Identities = 207/978 (21%), Positives = 422/978 (43%), Gaps = 115/978 (11%)
Query: 156 EEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAER--KEAKQEKEEADRY---- 209
EE R L E K ++ + + EE + ++ + E+ EAK +K E ++
Sbjct: 926 EEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILED 985
Query: 210 QRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELAS-KNK------EIEKDKKRMDKVEDE 262
Q K + ++ ++ + N E E+ +K LA KNK ++E+ +R +K E
Sbjct: 986 QNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQE 1045
Query: 263 LKEKKKEL-----------GKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKK 311
L++ +++L ++ + +++ ++ +K+ EL + + +E
Sbjct: 1046 LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEEL---QAALARVEE-------- 1094
Query: 312 LEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQ 371
EAA+K++ A K ++ + + EL++++ E E +++ Q RDL E
Sbjct: 1095 -EAAQKNM--ALKKIRELESQISELQEDL--------ESERASRNKAEKQKRDLGEELEA 1143
Query: 372 VKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKV------ETEAKIKQKL 425
+K E +T AQ+ + R+Q+ + + LEE K E K Q +
Sbjct: 1144 LK-----TELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAV 1198
Query: 426 REIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLG 485
E+ E ++ ++++ + +KQ+LE ++ GEL EV++ + + + +V QL
Sbjct: 1199 EELAEQLEQTKRVKANLEKAKQTLENER---GELANEVKVLLQGKGDSEHKRKKVEAQLQ 1255
Query: 486 DARIDRQESSRQQRKAEIMESIKRLYP--GSVYGRLIDLCQPTQKKYQIAVTKVLGKNMD 543
+ ++ E R + E+ + + +L +V G L + K L K+
Sbjct: 1256 ELQVKFNEGERV--RTELADKVTKLQVELDNVTGLLSQSDSKSSK---------LTKDFS 1304
Query: 544 AIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAK----LVIDVIR 599
A+ + T ++ +Q Q+ T L E E+L E + AK I +
Sbjct: 1305 ALESQLQDT-QELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLH 1363
Query: 600 YEPPHIKKALQYACGNALVCDNVE-DARRIAFGGHQRH-KTVALDGTLFQKSGVISGGAS 657
+ +KK ++ + G + V+ ++ G QRH + VA L + +
Sbjct: 1364 AQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELD 1423
Query: 658 DLKAKARRWDEKAVDKLKEKK-------ERLTEELKEQMKAKRKEAELRQVQSQAHGLQM 710
DL + A + K++K E T K + R EAE R+ +++A L
Sbjct: 1424 DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLAR 1483
Query: 711 RLKYSQSDLEQTKTRHLALNLQEKSKLE---SELANFGPRINDIKRIIQSREREMKDLKE 767
L+ + + K LN Q ++++E S + G ++++++ ++ E++++++K
Sbjct: 1484 ALE----EAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKT 1539
Query: 768 KMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQ 827
++ ++EDE+ + + +R + K + + ++ + + E +K +L Q+ + +
Sbjct: 1540 QLEELEDEL--QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAE 1597
Query: 828 LKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDK 887
L++++ + M KK E +++ L+ K DE + QL+ L+ Q E++D
Sbjct: 1598 LEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDT 1657
Query: 888 NHEMEEI-------RKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKL 940
EEI KKL EM LQ+E+ A E Q + +R L K
Sbjct: 1658 RASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKG 1717
Query: 941 PLSKGTMDDISQEEGSSQGE-DSVSGSQRISSIYAREALIEIDY--GDLCEDLKDAQAEE 997
L+ + + E + G+ + + ++A ++ID DL + AQ E
Sbjct: 1718 ALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNE 1777
Query: 998 EIKQEM----NTLQQKLNEQQSVLQRIAAPNMKAME-KLESVRDKFQETSDEFEAA---- 1048
+Q++ L+ KL E + ++ ++ A+E K+ + ++ + E +AA
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV 1837
Query: 1049 RKRAKKAKQAFEQIKKER 1066
R+ KK K Q+ ER
Sbjct: 1838 RRTEKKLKDVLLQVDDER 1855
Score = 115 bits (289), Expect = 2e-25
Identities = 158/790 (20%), Positives = 344/790 (43%), Gaps = 102/790 (12%)
Query: 139 AVESIA--MKNPKERTALFEEISRS-----GELAQEYDKRKKEMVKAEEDTQFNYHRKKN 191
AVE +A ++ K A E+ ++ GELA E K +++ + D++ H++K
Sbjct: 1197 AVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV----KVLLQGKGDSE---HKRKK 1249
Query: 192 IAAERKEAKQEKEEADRYQ-RLKDEVVRAQVQLQLFK--LYHNEVEIEKLNKELASKNKE 248
+ A+ +E + + E +R + L D+V + QV+L L ++ + KL K+ ++ +
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ 1309
Query: 249 IEKDKK--------------RMDKVEDELKEKKKELGKMMREQQQIEKEIKE---KDSEL 291
++ ++ ++ +VEDE +++L + + +EK+I + +++
Sbjct: 1310 LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADM 1369
Query: 292 NQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFE 351
+K + E +KL+ K L+ + ++++ D+LEK + + +QE +
Sbjct: 1370 KKKMEDSVGCLETAEEVKRKLQ---KDLEGLSQRHEEKVAAYDKLEK---TKTRLQQELD 1423
Query: 352 ERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEE 411
+ + + + LE+ Q KK+ +L E +A A+E +DR + E
Sbjct: 1424 DLLVDLDHQRQSACNLEKKQ-KKFDQLLAEEKTISAKYAEE-----------RDRAEAEA 1471
Query: 412 RKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRID 471
R+K + + L E E + +E+L + T + L K G+ E+E +KR ++
Sbjct: 1472 REKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531
Query: 472 EINKELNQVMEQLGDARIDRQESSRQQRKAEI-MESIKRLYPGSVYGRLIDLCQPTQKKY 530
+ +E+ +E+L D + Q + + + E+ ++++K + + GR + +++K
Sbjct: 1532 QQVEEMKTQLEELED---ELQATEDAKLRLEVNLQAMKAQFERDLQGR----DEQSEEKK 1584
Query: 531 QIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKG 590
+ V +V + M+A + D K + K+ + + K DE +++L+
Sbjct: 1585 KQLVRQV--REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR- 1641
Query: 591 AKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSG 650
KL +A C L +A K +++ + Q
Sbjct: 1642 -KL-------------QAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQE 1687
Query: 651 VISGGASDLKAKARRWDEKAVDKLKEK--KERLTEELKEQMKAK--RKEAELRQVQSQAH 706
++ A K +A++ ++ D++ K L E K +++A+ + E EL + Q
Sbjct: 1688 ELA-AAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTE 1746
Query: 707 GLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLK 766
+ RLK + ++Q T LNL+ ++E A Q ER+ K+LK
Sbjct: 1747 LINDRLKKANLQIDQINT---DLNLERSHAQKNENAR------------QQLERQNKELK 1791
Query: 767 EKMNQVEDEVFEEF-----CREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQL 821
K+ ++E V ++ E + + E + + K + K+ E + + +Q+
Sbjct: 1792 VKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQV 1851
Query: 822 DFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKK 881
D E+ ++ +D+ +K+ + ++E+ ++E QR + +L+D A
Sbjct: 1852 DDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMN 1911
Query: 882 SEVNDKNHEM 891
EV+ +++
Sbjct: 1912 REVSSLKNKL 1921
Score = 113 bits (283), Expect = 1e-24
Identities = 214/1062 (20%), Positives = 448/1062 (42%), Gaps = 178/1062 (16%)
Query: 86 EEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKAR------NFLVFQGA 139
EE A + + + K+ + + L + + +L K L++ R N +
Sbjct: 955 EESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014
Query: 140 VESIA-MKNPKER--TALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAER 196
+S+A +KN E T L E + R + QE +K ++++ D + AE
Sbjct: 1015 SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAEL 1074
Query: 197 KEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRM 256
K +KEE + + E AQ + L K+ E +I +L ++L S+ K +K+
Sbjct: 1075 KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQK 1134
Query: 257 DKVEDELKEKKKELG------------KMMREQQ------QIEKEIKEKDSELNQKRPQY 298
+ +EL+ K EL + REQ+ +E+E K ++++ + R ++
Sbjct: 1135 RDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH 1194
Query: 299 IKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEES 358
+A E + ++++ + K +L+ A++ + +G++ K +L + + +++E +
Sbjct: 1195 SQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ- 1253
Query: 359 QSQGRDLTLEENQVK--KYHRLKEEASKRAATLAQELEKFN--RDQKADQDRLDLEERKK 414
L+E QVK + R++ E + + L EL+ Q + ++
Sbjct: 1254 --------LQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305
Query: 415 VETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEIN 474
+E++ + Q+L + EEN++++ ++T + +E++K E EE E AK ++
Sbjct: 1306 LESQLQDTQELLQ-EENRQKLS-----LSTKLKQVEDEKNSFREQLEEEEEAKHNLE--- 1356
Query: 475 KELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKY---- 530
K++ + Q+ D + ++S E E +KR + G L Q ++K
Sbjct: 1357 KQIATLHAQVADMKKKMEDS---VGCLETAEEVKRKLQKDLEG----LSQRHEEKVAAYD 1409
Query: 531 QIAVTKV-LGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELK 589
++ TK L + +D ++VD + + K+Q+ + + K +E+ R
Sbjct: 1410 KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEA 1469
Query: 590 GAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKS 649
A+ KAL A + + R+ +++ +T D L
Sbjct: 1470 EAR----------EKETKALSLARALEEAMEQKAELERL----NKQFRTEMED--LMSSK 1513
Query: 650 GVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAK-RKEAELRQVQSQ-AHG 707
+ +L+ K++R E+ V+++K + E L +EL+ AK R E L+ +++Q
Sbjct: 1514 DDVGKSVHELE-KSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERD 1572
Query: 708 LQMRLKYSQSDLEQ--TKTRHLALNLQE-----------KSKLESELANFGPRINDIKRI 754
LQ R + S+ +Q + R + L++ + KLE +L + I+ +
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANK- 1631
Query: 755 IQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQK 814
+R+ +K L++ Q++D C +RE ++ + R+ +A+ + EN+K
Sbjct: 1632 --NRDEAIKQLRKLQAQMKD------C-------MRELDDTRASREEILAQAK---ENEK 1673
Query: 815 TRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIE----------KLKKEEQRHMKIID 864
++ E QL+E+ ++ +++ +E+ L EE+R ++
Sbjct: 1674 KLK--SMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRR---LE 1728
Query: 865 ETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRS 924
+AQL++ E+ ++ E I +L AN ++ + ++ + ++ +
Sbjct: 1729 ARIAQLEE----------ELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNEN 1778
Query: 925 DRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYG 984
R L + K +KL +GT+ S+ +SI A EA
Sbjct: 1779 ARQQLERQNKELKVKLQEMEGTVK-----------------SKYKASITALEA------- 1814
Query: 985 DLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDK---FQET 1041
K AQ EE++ E E+Q+ +++ K + L V D+ ++
Sbjct: 1815 ------KIAQLEEQLDNE-------TKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY 1861
Query: 1042 SDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDE 1083
D+ + A R K+ K+ E+ ++E R NA + +++
Sbjct: 1862 KDQADKASTRLKQLKRQLEEAEEEA-QRANASRRKLQRELED 1902
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 137 bits (345), Expect = 6e-32
Identities = 218/1045 (20%), Positives = 446/1045 (42%), Gaps = 128/1045 (12%)
Query: 108 NNKVVQLHEYSEEL----EKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGE 163
N+ ++QL E L E+ LIK++ + + V+ ++ + +E E +R +
Sbjct: 897 NDLILQLQAEQETLANVEEQCEWLIKSK--IQLEARVKELSERVEEEEEINSELTARGRK 954
Query: 164 LAQEYDKRKKE-------MVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADR-------- 208
L E + KKE +VK+E++ + H+ KN+ E + ++ + +R
Sbjct: 955 LEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEA 1014
Query: 209 YQRLKDEVVRAQVQLQLFKLYHNEVE--IEKLNKELASKNKEIEKDKKRMDKVEDELKEK 266
+Q+ D++ + +L + ++E +++L L + K ++ + K+E LK
Sbjct: 1015 HQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLN 1074
Query: 267 KKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHY 326
++ + + Q+ + +E+++K+ EL+Q + EN + +L+ K LQ K
Sbjct: 1075 RESMENLESSQRHLAEELRKKELELSQMNSKV----ENEKGLVAQLQKTVKELQTQIKDL 1130
Query: 327 KKR----KGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTL---EENQVKKYHRLK 379
K++ + ++E+E + + + ER+EE S L + +E + +K HR
Sbjct: 1131 KEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDM 1190
Query: 380 EEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKL-REIEENQKRIEKL 438
EEA+ T + L+K + D A E +VE ++KQKL ++ + Q ++ L
Sbjct: 1191 EEATLHFETTSASLKKRHADSLA-------ELEGQVENLQQVKQKLEKDKSDLQLEVDDL 1243
Query: 439 EEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQ 498
+ ++ +KL E + A ++D++ + N + Q + E R+
Sbjct: 1244 LTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRL 1303
Query: 499 RKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQ 558
+ E + + + ++ DL +K+ K+ A+ +K RDC
Sbjct: 1304 EEKEALINQLSREKSNFTRQIEDLRGQLEKE---------TKSQSALAHALQKAQRDC-D 1353
Query: 559 YIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHI---------KKAL 609
++EQ E + EVK + A++V ++YE I KK L
Sbjct: 1354 LLREQYEEEQ--------EVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKEL 1405
Query: 610 QYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEK 669
A V +AR + RH+ G G + A+ L K + K
Sbjct: 1406 AIRLQEAAEAMGVANARNASL-ERARHQLQLELGDALSDLGKVRSAAARLDQKQLQ-SGK 1463
Query: 670 AVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLAL 729
A+ K+K EE + + A +KE + + L+++ Y +S + Q R
Sbjct: 1464 ALADWKQKH----EESQALLDASQKEVQALSTEL----LKLKNTYEESIVGQETLRRENK 1515
Query: 730 NLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFE-EFCREIGVRN 788
NLQE E++N ++ + + + E+ K ++E+ +V+ + E E E
Sbjct: 1516 NLQE------EISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESK 1569
Query: 789 IREFE----EEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKK 844
I F+ E K + + ++++K E EN + + +D ++ L + + KK
Sbjct: 1570 ILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKK 1629
Query: 845 DENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKE 904
E ++ +++ + + + E L L+ Q + +++D ++++++ A +
Sbjct: 1630 MEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERR 1689
Query: 905 MTHLQKEVTAIETKLEQ----KRSDRHNLLQACK------MQDIKLPLSKGTMD-DISQE 953
+ LQ E+ + + EQ +R LL+A + Q+ L K ++ D+++
Sbjct: 1690 NSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARM 1749
Query: 954 EGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQ--------AEEEIKQEMNT 1005
+ + E+ V Q A++A IE +L E+LK Q E ++Q +
Sbjct: 1750 Q--KEAEEVVQECQNAEE-KAKKAAIEA--ANLSEELKKKQDTIAHLERTRENMEQTITD 1804
Query: 1006 LQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKE 1065
LQ++L E + Q + K ++KLES + +E E E +R+ +A++ ++++
Sbjct: 1805 LQKRLAEAE---QMALMGSRKQIQKLES---RVRELEGELEGEIRRSAEAQRGARRLER- 1857
Query: 1066 RFDRFNACFESVATNIDEIYKALSR 1090
C + + +E K LSR
Sbjct: 1858 -------CIKELTYQAEEDKKNLSR 1875
Score = 117 bits (292), Expect = 9e-26
Identities = 189/983 (19%), Positives = 425/983 (43%), Gaps = 106/983 (10%)
Query: 160 RSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRA 219
+S E+ +E K+E + ++ + + +++ + A++ QEK + + + E + A
Sbjct: 853 KSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETL-A 911
Query: 220 QVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMD----KVEDELKEKKKELGKMMR 275
V+ Q L +++++E KEL+ + +E E+ + K+EDE E KKE+ +
Sbjct: 912 NVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDL-- 969
Query: 276 EQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDE 335
E ++ E +++ +E K + E + I KL A K +Q A +++ D+
Sbjct: 970 ETMLVKSEKEKRTTE--HKVKNLTEEVEFLNEDISKLNRAAKVVQEA---HQQTLDDLHM 1024
Query: 336 LEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEK 395
E+++ S+ KA + E++++E + ++ N ++ H+L+ + +E
Sbjct: 1025 EEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLN----RESMEN 1080
Query: 396 FNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKL 455
Q+ + L +E + + +K++ + + + QK +++L+ I K+ LE ++
Sbjct: 1081 LESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTT 1140
Query: 456 EGELTEEVEMAKRRIDEINKELNQV-MEQLGDARIDRQESSRQQRKAEIME--------- 505
++ E + + ++N+ L +V L I +++ ++ Q+ ME
Sbjct: 1141 RAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETT 1200
Query: 506 --SIKRLYPGS---VYGRLIDLCQPTQK------KYQIAVTKVLGK--NMDAIIVDSEKT 552
S+K+ + S + G++ +L Q QK Q+ V +L + M ++EK
Sbjct: 1201 SASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKL 1260
Query: 553 GRDCIQYIKEQRGEPE--TFLPLDYLEVK-----PTDEKLRELKGAKLVIDVIRYEPPHI 605
+ + E + + T L D K + E LR L+ + +I+ + E +
Sbjct: 1261 CTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNF 1320
Query: 606 KKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQK--SGVISGGASDLKAKA 663
+ ++ G + A A QR + + ++ + S + A+
Sbjct: 1321 TRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEM 1380
Query: 664 RRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQV--------QSQAHGLQMRLKYS 715
+W K + + ++ E L + KE ++ AE V + H LQ+ L +
Sbjct: 1381 VQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDA 1440
Query: 716 QSDLEQTKTRHLALNLQEKSKLES--ELANFGPRINDIKRIIQSREREMKDLKEKMNQVE 773
SDL K R A L +K +L+S LA++ + + + ++ + ++E++ L ++ +++
Sbjct: 1441 LSDL--GKVRSAAARLDQK-QLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLK 1497
Query: 774 DEVFEEFCREIGVR-----------NIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLD 822
+ E + +R N+ E K E+ K + E +KT + + L+
Sbjct: 1498 NTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLE 1557
Query: 823 FEKNQLKEDQDKVHMW-----------EQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQ 871
+ L+ ++ K+ + E+ + + + EIE ++++Q ID + L
Sbjct: 1558 ETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQ---CTIDSLQSSLD 1614
Query: 872 D-----LKNQHLAKKSE--VNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRS 924
++ L KK E +N+ ++ +++ A K + LQ ++ ++ +L+
Sbjct: 1615 SEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQ 1674
Query: 925 DRHNLLQACKMQDIKLPLSKGTMDDI-SQEEGSSQG-----EDSVSGSQRISSIYAREAL 978
+L + + + + L + ++D+ S +E + +G E+ + ++RI+ Y +
Sbjct: 1675 LNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTS 1734
Query: 979 IEIDYGDLCEDLKDAQAE-EEIKQEMNTLQQKLNE---QQSVLQRIAAPNMKAMEKLESV 1034
+ L D+ Q E EE+ QE ++K + + + L + LE
Sbjct: 1735 LLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERT 1794
Query: 1035 RDKFQETSDEFEAARKRAKKAKQ 1057
R+ ++T + + KR +A+Q
Sbjct: 1795 RENMEQTITDLQ---KRLAEAEQ 1814
Score = 80.9 bits (198), Expect = 7e-15
Identities = 166/863 (19%), Positives = 353/863 (40%), Gaps = 147/863 (17%)
Query: 99 VGGSS------EYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERT 152
VGGSS K K +LH EE L F+ S+ ++
Sbjct: 1165 VGGSSLAQLEITKKQETKFQKLHRDMEEAT-----------LHFETTSASLKKRHADSLA 1213
Query: 153 ALFEEISRSGELAQEYDKRKKEM--------VKAEEDTQFNYHRKKNIAAERKEAKQEKE 204
L ++ ++ Q+ +K K ++ + E+ T+ + +K + +
Sbjct: 1214 ELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATA 1273
Query: 205 EADRYQRLKDEVVRAQVQLQ------LFKLYHNEVEIEKLNKELASKNKEIE-------K 251
+ D+ +L +++ + +L L +L E I +L++E ++ ++IE K
Sbjct: 1274 KLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEK 1333
Query: 252 DKKRMDKVEDELKEKKKE---LGKMMREQQQIEKEIKEKDSELNQKRPQY-IKAKENTSH 307
+ K + L++ +++ L + E+Q+++ E+ S++N + Q+ +K + N
Sbjct: 1334 ETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQ 1393
Query: 308 KIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFE---------------- 351
+ + LE AKK L + + G + S+E+AR + +
Sbjct: 1394 RTEDLEDAKKELAIRLQEAAEAMGVANARNA---SLERARHQLQLELGDALSDLGKVRSA 1450
Query: 352 -ERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKAD---QDRL 407
R++++ G+ L + + ++ L + + K L+ EL K + Q+ L
Sbjct: 1451 AARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETL 1510
Query: 408 DLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELT-EEVEMA 466
E + E + + ++RE +N +EK+++ I E++K E ++T EE E A
Sbjct: 1511 RRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLI--------EEEKTEVQVTLEETEGA 1562
Query: 467 KRRIDEINKELNQVMEQL-GDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQP 525
R + +K L+ +E L A ++R+ S K E +E+ +R ++ L
Sbjct: 1563 LERNE--SKILHFQLELLEAKAELERKLSE----KDEEIENFRRKQQCTIDSLQSSL--D 1614
Query: 526 TQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKL 585
++ K +I VT+ L K M+ + + E +Q R E L L+++ D ++
Sbjct: 1615 SEAKSRIEVTR-LKKKMEEDLNEME------LQLSCANRQVSEATKSLGQLQIQIKDLQM 1667
Query: 586 RELKGAKLVIDVIRYEPPHIKKALQYA-CGNALVCDNVEDARRIAFGGHQRHKTVALDGT 644
+ +L D +K+ + A N+L+ +ED R +
Sbjct: 1668 QLDDSTQLNSD--------LKEQVAVAERRNSLLQSELEDLRSL---------------- 1703
Query: 645 LFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERL----TEELKEQMKAKRKEAELRQ 700
+ + RR E ++L E ER+ T+ + K+ EA++ +
Sbjct: 1704 ------------QEQTERGRRLSE---EELLEATERINLFYTQNTSLLSQKKKLEADVAR 1748
Query: 701 VQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSRER 760
+Q +A + + ++ K + A+ E + L EL I ++R ++ E+
Sbjct: 1749 MQKEAEEVVQECQNAEE-----KAKKAAI---EAANLSEELKKKQDTIAHLERTRENMEQ 1800
Query: 761 EMKDLKEKMNQVEDEVFEEFCREIGV--RNIREFEEE---KVKRQNEIAKKRLEFENQKT 815
+ DL++++ + E ++I +RE E E +++R E + E
Sbjct: 1801 TITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIK 1860
Query: 816 RLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKN 875
L Q + +K L Q ++ + V+ + ++E + + +++ + +L ++K
Sbjct: 1861 ELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKE 1920
Query: 876 QHLAKKSEVNDKNHEMEEIRKKL 898
+ +S+VN + E KK+
Sbjct: 1921 RAEVAESQVNKLKIKAREFGKKV 1943
Score = 52.8 bits (125), Expect = 2e-06
Identities = 60/310 (19%), Positives = 133/310 (42%), Gaps = 49/310 (15%)
Query: 172 KKEMVKAEEDTQFNYHRKKNIA----------AERKEAKQEKEEADRYQRL-KDEVVRAQ 220
K ++ ++ TQ N K+ +A +E ++ + +E+ +R +RL ++E++ A
Sbjct: 1663 KDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEAT 1722
Query: 221 VQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQI 280
++ LF N L S+ K++E D RM K E +++
Sbjct: 1723 ERINLFYTQ---------NTSLLSQKKKLEADVARMQK-----------------EAEEV 1756
Query: 281 EKEIKEKDSELNQKRPQYIKAKENTSHK---IKKLEAAKKSLQNAQKHYKKRKGDMDEL- 336
+E + + + + + E K I LE +++++ +KR + +++
Sbjct: 1757 VQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMA 1816
Query: 337 ----EKEMLSVEKARQEFEERMEEE---SQSQGRDLTLEENQVKKYHRLKEEASKRAATL 389
K++ +E +E E +E E S R E +K+ EE K + +
Sbjct: 1817 LMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRM 1876
Query: 390 AQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSK-QS 448
+++K + + ++++ E + + +K K++ E+ E ++R E E + K ++
Sbjct: 1877 QTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKA 1936
Query: 449 LEEQKKLEGE 458
E KK++ E
Sbjct: 1937 REFGKKVQEE 1946
Score = 46.2 bits (108), Expect = 2e-04
Identities = 44/215 (20%), Positives = 100/215 (46%), Gaps = 19/215 (8%)
Query: 158 ISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQE-KEEADRYQRLKDEV 216
+S+ +L + + +KE + ++ Q + K A E +E K++ D L E
Sbjct: 1736 LSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHL--ER 1793
Query: 217 VRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMRE 276
R ++ + L E E++ L K+I+K + R+ ++E EL+ + + + R
Sbjct: 1794 TRENMEQTITDLQKRLAEAEQM--ALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRG 1851
Query: 277 QQQIEKEIK-------EKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKR 329
+++E+ IK E L++ + Q K + + +++E A+ YKK+
Sbjct: 1852 ARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQ 1911
Query: 330 KGDMDEL-------EKEMLSVEKARQEFEERMEEE 357
+ +++E+ E ++ ++ +EF ++++EE
Sbjct: 1912 QHELNEVKERAEVAESQVNKLKIKAREFGKKVQEE 1946
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 133 bits (335), Expect = 9e-31
Identities = 199/1015 (19%), Positives = 441/1015 (43%), Gaps = 109/1015 (10%)
Query: 109 NKVVQLHEYSEELEKLGILIKARNFLVFQGAV--ESIAMKNPKERTALFEEISRSGELAQ 166
+ + E ++L K I ++A+ V + A E I + ++ L +E S EL +
Sbjct: 900 DSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECS---ELKK 956
Query: 167 EYDKRKKEMVKAEEDTQFNYHRKKNIAAER--------KEAKQEKEEADRYQRLKDEVVR 218
+ D + + K E++ ++ KN+ E K K++K + +Q+ D++
Sbjct: 957 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA 1016
Query: 219 AQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKK-RMD------KVEDELKEKKKELG 271
+ ++ + +I KL +++ +E++KK RMD K+E +LK ++
Sbjct: 1017 EEDKVNTL----TKAKI-KLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTM 1071
Query: 272 KMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKG 331
+ ++QQ+++++K+K+ E++ + + + KK++ + ++ ++ + +
Sbjct: 1072 DIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERA 1131
Query: 332 DMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLK---EEASKRAAT 388
+ EK+ + + +E ER+EE + + + + + ++ +++ EEA+ +
Sbjct: 1132 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191
Query: 389 LAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKL-REIEENQKRIEKLEEYITTSKQ 447
A L K + D A E ++++ ++KQKL +E E + I+ L + T +
Sbjct: 1192 TAATLRKKHADSVA-------ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSK 1244
Query: 448 SLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQ-QRKAEIMES 506
+ +K+ L +++ K + +E + +N + Q + + E SRQ K ++
Sbjct: 1245 AKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQ 1304
Query: 507 IKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGE 566
+ R G+ Q + K Q+ ++ K+ A + S + DC ++EQ E
Sbjct: 1305 LSR-------GKQAFTQQIEELKRQLE-EEIKAKSALAHALQSSR--HDC-DLLREQYEE 1353
Query: 567 PETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDAR 626
+ E K ++ +++ +YE I++ + + ++DA
Sbjct: 1354 EQ--------EAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1405
Query: 627 RIAFGGHQRHKTVALDGTLFQKSGVISGGASDLK---AKARRWDEKA--VDKLKEKKERL 681
+ K +L+ T + + D++ A D+K DK+ + ++
Sbjct: 1406 EHVEAVNA--KCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQK 1463
Query: 682 TEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESEL 741
EE +++A +KE+ R + ++ ++ + S LE K + L QE S L ++
Sbjct: 1464 CEETHAELEASQKES--RSLSTELFKIKNAYEESLDQLETLKRENKNLQ-QEISDLTEQI 1520
Query: 742 ANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGV------------RNI 789
A G RI+++++I + E+E +L+ + + E + E + + + R I
Sbjct: 1521 AEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI 1580
Query: 790 REFEEE--KVKRQN----EIAKKRLEFE----NQKTRLGIQLDFEKNQLKEDQDKVHMWE 839
E +EE ++KR + E + L+ E N RL +++ + N+++ + +
Sbjct: 1581 AEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMA 1640
Query: 840 QTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLG 899
++ + + K+ Q H+ D+ + +DLK Q + N E+EE+R L
Sbjct: 1641 AEALRNYRNTQAILKDTQLHL---DDALRSQEDLKEQLAMVERRANLLQAEIEELRATLE 1697
Query: 900 GANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQG 959
+ ++E+ +++ + +L+ K + + +G M+DI QE +
Sbjct: 1698 QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQE--ARNA 1755
Query: 960 EDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQR 1019
E+ + +++ A E E D E +K + ++Q + LQ +L+E + Q
Sbjct: 1756 EEKAKKAITDAAMMAEELKKEQDTSAHLERMK-----KNLEQTVKDLQHRLDEAE---QL 1807
Query: 1020 IAAPNMKAMEKLES-VRDKFQETSDE-------FEAARKRAKKAKQAFEQIKKER 1066
K ++KLE+ VR+ E E + RK +K K+ Q +++R
Sbjct: 1808 ALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDR 1862
Score = 122 bits (306), Expect = 2e-27
Identities = 195/995 (19%), Positives = 432/995 (43%), Gaps = 138/995 (13%)
Query: 190 KNIAAERKEAKQEKE-EADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKE 248
K+ E++ A ++E E + + K E R +++ ++ L + +++ + A +
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904
Query: 249 IEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHK 308
E+ ++ K + +L+ K KE+ + ++++I E+ K +L + + K ++
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 964
Query: 309 IKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLE 368
+ K+E K + +N K+ + +DE ++ +KA QE ++ + DL E
Sbjct: 965 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD-------DLQAE 1017
Query: 369 ENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEE-RKKVETEAKIKQKLRE 427
E++V + K + ++ L LE + + R+DLE ++K+E + K+ Q+
Sbjct: 1018 EDKVNTLTKAKIKLEQQVDDLEGSLE------QEKKIRMDLERAKRKLEGDLKLAQESTM 1071
Query: 428 IEENQK-----RIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVME 482
EN K +++K E ++ + +E+++ L +L ++++ + RI+E+ +E+ E
Sbjct: 1072 DIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIE--AE 1129
Query: 483 QLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNM 542
+ A+ ++Q S + EI E ++ G I++ + + ++Q + +++
Sbjct: 1130 RASRAKAEKQRSDLSRELEEISERLEE--AGGATSAQIEMNKKREAEFQ-----KMRRDL 1182
Query: 543 DAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKL-RELKGAKLVIDVIRYE 601
+ + E T ++++ + L ++ +KL +E K+ ID +
Sbjct: 1183 EEATLQHEATAAT----LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1238
Query: 602 PPHIKKALQYACGN-ALVCDNVEDARRIAFGGHQRHKTVALDGT-----LFQKSGVISGG 655
+ KA GN +C +ED + + + D T L +SG S
Sbjct: 1239 METVSKAK----GNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQ 1294
Query: 656 ASD---LKAKARRWDEKAVDKLKEKKERLTEELKEQ------MKAKRKEAEL-----RQV 701
+ L ++ R + +++E K +L EE+K + +++ R + +L +
Sbjct: 1295 LDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEE 1354
Query: 702 QSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSRERE 761
Q LQ + + S++ Q +T++ +Q +LE R+ D + +++ +
Sbjct: 1355 QEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAK 1414
Query: 762 MKDLKEKMNQVEDEVFEEFCREIGVRNI---------REFEE--EKVKRQNEIAKKRLEF 810
L++ ++++EV E+ ++ N R F++ + K++ E LE
Sbjct: 1415 CASLEKTKQRLQNEV-EDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEA 1473
Query: 811 ENQKTR-LGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQ 869
+++R L +L KN +E D++ ++ K + EI L ++ K I E
Sbjct: 1474 SQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE---- 1529
Query: 870 LQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNL 929
L+ +K Q +KSE+ +EE L ++ +Q E+ +++++++K +++
Sbjct: 1530 LEKIKKQVEQEKSEL---QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1586
Query: 930 LQACKMQDIKLPLS-KGTMD-DISQEEGSSQGEDSVSGSQRISSI-------YAREALIE 980
+ K I++ S + T+D +I + + + + G I A EAL
Sbjct: 1587 IDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL-- 1644
Query: 981 IDYGDLCEDLKDAQ--------AEEEIKQEM-------NTLQQKLNEQQSVLQRIAAPNM 1025
+Y + LKD Q ++E++K+++ N LQ ++ E ++ L++
Sbjct: 1645 RNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1704
Query: 1026 KAMEKLESVRDKFQ-------------------------ETSDEFEAARKRAKKAKQAF- 1059
A ++L ++ Q E D + AR +KAK+A
Sbjct: 1705 IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAIT 1764
Query: 1060 ------EQIKKERFDRFNACFESVATNIDEIYKAL 1088
E++KKE+ +A E + N+++ K L
Sbjct: 1765 DAAMMAEELKKEQ--DTSAHLERMKKNLEQTVKDL 1797
Score = 99.8 bits (247), Expect = 1e-20
Identities = 154/794 (19%), Positives = 334/794 (42%), Gaps = 104/794 (13%)
Query: 134 LVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHR----- 188
L + ++ K+ L E+I + Q+ +K K EM +D N
Sbjct: 1187 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAK 1246
Query: 189 ---KKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLF------KLYHNEVEIEKLN 239
+K A + + K + + QRL +++ + +LQ +L + + +L+
Sbjct: 1247 GNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLS 1306
Query: 240 KELASKNKEIEKDKKRMDKVEDELKEKK---------KELGKMMREQQQIEKEIKEK--- 287
+ + ++IE+ K+++ E+E+K K + ++REQ + E+E K +
Sbjct: 1307 RGKQAFTQQIEELKRQL---EEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363
Query: 288 -----DSELNQKRPQYIKAKENTSHKIKKLEAAKKSL----QNAQKHYKKRKGDMDELEK 338
+SE+ Q R +Y + + + ++LE AKK L Q+A++H + LEK
Sbjct: 1364 AMSKANSEVAQWRTKY---ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEK 1420
Query: 339 EMLSVEKARQEFEERMEEESQSQGRDLTLEENQ-------------VKKYHRLKEEASKR 385
+ ++ + E E+ M + ++ L++ Q ++ H E + K
Sbjct: 1421 ---TKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE 1477
Query: 386 AATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTS 445
+ +L+ EL K + D+L+ +R+ + +I +I E KRI +LE+
Sbjct: 1478 SRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK---IK 1534
Query: 446 KQSLEEQKKLEGELTE---EVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRK-- 500
KQ +E+ +L+ L E +E + +I I ELNQV ++ ++ E Q ++
Sbjct: 1535 KQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNH 1594
Query: 501 AEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYI 560
I+ES++ + R I + K + +++ + + R + +
Sbjct: 1595 IRIVESMQSTLDAEIRSR----------NDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1644
Query: 561 KEQRGE----PETFLPLDYLEVKPTDEKLRE-LKGAKLVIDVIRYEPPHIKKALQYACGN 615
+ R +T L LD + + E L+E L + ++++ E ++ L+ +
Sbjct: 1645 RNYRNTQAILKDTQLHLD--DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERS 1702
Query: 616 ALVCDN--VEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDK 673
+ + ++ + R+ Q + L I G D+ +AR +EKA
Sbjct: 1703 RKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKA--- 1759
Query: 674 LKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQE 733
K+ +T+ + K+++ ++ L+ +K Q L++ + L ++
Sbjct: 1760 ----KKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ 1815
Query: 734 KSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFE-EFCREIGVRNIREF 792
KLE+ R+ +++ ++S ++ + + + + E +V E + E +NI
Sbjct: 1816 IQKLEA-------RVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRL 1868
Query: 793 EEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKL 852
++ K Q ++ + + E + + + L ++ + Q ++ E+ E+++ KL
Sbjct: 1869 QDLVDKLQAKVKSYKRQAEEAEEQSNVNL----SKFRRIQHELEEAEERADIAESQVNKL 1924
Query: 853 K-KEEQRHMKIIDE 865
+ K + H KII E
Sbjct: 1925 RVKSREVHTKIISE 1938
Score = 72.8 bits (177), Expect = 2e-12
Identities = 91/362 (25%), Positives = 164/362 (45%), Gaps = 50/362 (13%)
Query: 731 LQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMN-----------QVEDEV--- 776
L + ++ E E+AN K + E + K+L+EKM QV+ E
Sbjct: 843 LLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSL 902
Query: 777 --FEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDK 834
EE C ++ I+ E K+K E A+ E + T +L+ E ++LK+D D
Sbjct: 903 ADAEERCDQLIKTKIQL--EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 960
Query: 835 VHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQL-QDLKNQHLAKKSEVNDKNHEMEE 893
+ + V+K+++ E K M +DET+A+L ++ K A + ++D E +
Sbjct: 961 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED- 1019
Query: 894 IRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQ- 952
K+ K L+++V +E LEQ++ R +L +A + + L L++ + DI
Sbjct: 1020 ---KVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIEND 1076
Query: 953 ----EEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQA-----EEEIKQEM 1003
+E + E +SG Q S I +AL L + +K+ QA EEEI+ E
Sbjct: 1077 KQQLDEKLKKKEFEMSGLQ--SKIEDEQAL----GMQLQKKIKELQARIEELEEEIEAE- 1129
Query: 1004 NTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIK 1063
+ K +Q+S L R +LE + ++ +E A + KK + F++++
Sbjct: 1130 RASRAKAEKQRSDLSR----------ELEEISERLEEAGGATSAQIEMNKKREAEFQKMR 1179
Query: 1064 KE 1065
++
Sbjct: 1180 RD 1181
Score = 62.4 bits (150), Expect = 3e-09
Identities = 94/516 (18%), Positives = 215/516 (41%), Gaps = 80/516 (15%)
Query: 668 EKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAH--------------------- 706
EK + K + LTEE+ + K + ++ +AH
Sbjct: 969 EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK 1028
Query: 707 -GLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDL 765
L+ ++ + LEQ K + L + K KLE +L DI+ Q + ++K
Sbjct: 1029 IKLEQQVDDLEGSLEQEKKIRMDLE-RAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKK 1087
Query: 766 KEKMNQVEDEVFEEFCREIGV---RNIREFEEEKVKRQNEIAKK---RLEFENQKTRLGI 819
+ +M+ ++ ++ +E + +G+ + I+E + + + EI + R + E Q++ L
Sbjct: 1088 EFEMSGLQSKIEDE--QALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR 1145
Query: 820 QLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLA 879
+L+ +L+E + KK E E +K++++ + + T A L+ +H
Sbjct: 1146 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA---TLRKKHAD 1202
Query: 880 KKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIK 939
+E+ ++ ++ +++KL KE + ++ E+ + + +E + NL + C+ + +
Sbjct: 1203 SVAELGEQIDNLQRVKQKL---EKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQ 1259
Query: 940 LPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKD------- 992
L +I +E Q + I+ + A+ A ++ + G+ L +
Sbjct: 1260 L-------SEIKTKEEEQQ--------RLINDLTAQRARLQTESGEYSRQLDEKDTLVSQ 1304
Query: 993 -AQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSD-EFEAARK 1050
++ ++ Q++ L+++L E+ +A + + +R++++E + + E R
Sbjct: 1305 LSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRA 1364
Query: 1051 RAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDG 1110
+K + + K D E ++E K L++ E +++
Sbjct: 1365 MSKANSEVAQWRTKYETDAIQRTEE-----LEEAKKKLAQRL---------QDAEEHVEA 1410
Query: 1111 INYNCVAPGKRFRPMDN-----LSGGEKTVAALALL 1141
+N C + K + + N + E+T AA A L
Sbjct: 1411 VNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAAL 1446
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 133 bits (334), Expect = 1e-30
Identities = 199/921 (21%), Positives = 392/921 (42%), Gaps = 119/921 (12%)
Query: 224 QLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKK------ELGKMMREQ 277
+LF +++ + +E+ +K E++K K+R K E+ELKE ++ E +++EQ
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 278 QQIEKEIKEKDSELNQKRPQYIKAKENTSHKIK-KLEAAKKSLQNAQKHYKKRKGDMDEL 336
Q E E+ + E+ + + E H+++ +LE + Q Q KK M +L
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 337 EKEMLSVEKARQEFE-ERMEEESQSQGRD-----LTLEENQVKKYHRLKEE-ASKRAATL 389
E+++ E ARQ+ + E++ E++ + + + + N++ K +L EE S L
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 390 AQELEKFNRDQKAD----------QDRLDLEERKKVETEAKIKQKL--------REIEEN 431
A+E EK K + RL EE+ + E E K+K+KL +I +
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADL 1074
Query: 432 QKRIEKLEEYITTSKQSLEEQ-KKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARID 490
Q +I +L+ + ++ L+ +L+ E+ ++ A ++I E+ ++ + E L R
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQK-NNALKKIRELEGHISDLQEDLDSERAA 1133
Query: 491 RQESSRQQRK-AEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAV-TKVLGKNMDAIIVD 548
R ++ +Q+R E +E++K ++ +++ ++ V K L + +
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193
Query: 549 SEKTGRDCIQYIKEQRGEPETF--LPLDYLEVKPTDEKLR-ELKGAKLVIDVIRYEPPHI 605
++ + Q ++E + E F + + K T EK +L G V+ + E H
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 606 KKALQYACGN-ALVCDNVEDAR-RIAFGGHQ-RHKTVALDGTLFQKSGVISGGASDLKAK 662
KK L+ C + E AR + H+ +++ ++ G L + G A D+ +
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 663 ARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQT 722
+ +L++ +E L EE ++++ K LRQ++ + + LQ Q D E
Sbjct: 1314 S--------SQLQDTQELLQEETRQKLNVSTK---LRQLEEERNSLQ-----DQLDEE-- 1355
Query: 723 KTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCR 782
++ K LE ++ +++D K+ +Q ++ L+E + + E
Sbjct: 1356 --------MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE------- 1400
Query: 783 EIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTV 842
+ N+ + EEK +++ K + + + L + LD ++ + + K ++Q +
Sbjct: 1401 ---IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 843 KKDENEIEKLKKEEQRHMKIIDETMAQLQDLK---NQHLAKKSEVNDKNH----EMEEIR 895
+++N K E R E + L + L K E+ N EME++
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Query: 896 KKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNL---LQACKMQDIKLPLSKGTMDDISQ 952
K + L+K A+ET++E+ ++ L LQA +D KL L Q
Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA--TEDAKLRLEVNMQALKGQ 1575
Query: 953 EEGSSQGEDSVSGSQR-------------ISSIYAREALIEIDYGDLCEDLKDAQ----- 994
E Q D + +R + + AL L DLKD +
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 995 ----AEEEIKQ------EMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDE 1044
EE IKQ +M Q++L + ++ I A + +K +S+ + ++
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 1045 FEAARKRAKKAKQAFEQIKKE 1065
AA + K+A E++ +E
Sbjct: 1696 LAAAERARKQADLEKEELAEE 1716
Score = 130 bits (328), Expect = 6e-30
Identities = 208/1018 (20%), Positives = 436/1018 (42%), Gaps = 131/1018 (12%)
Query: 149 KERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAE---RKEAKQEKEE 205
KE +++ L QE + + E+ E+ + KK E EA+ E+EE
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935
Query: 206 ADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNK-EIEK--DKKRMDKVEDE 262
DR Q+L+ E R ++ Q+ L E+L +E A++ K ++EK + ++ K+EDE
Sbjct: 936 -DRGQQLQAE--RKKMAQQMLDLE------EQLEEEEAARQKLQLEKVTAEAKIKKLEDE 986
Query: 263 LKEKKKELGKMMREQQQIEKEIKEKDSEL---NQKRPQYIKAKENTSHKIKKLEAA---- 315
+ + K+ +E++ +E+ I + + L +K K K I +LE
Sbjct: 987 ILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE 1046
Query: 316 KKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERM---EEESQSQ----GRDLTLE 368
+KS Q +K +K +GD + +++ ++ E + ++ EEE Q+ ++ +
Sbjct: 1047 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106
Query: 369 ENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREI 428
N +KK L+ S L E N+ +K +D + E K E E + +
Sbjct: 1107 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1166
Query: 429 EENQKRIEKLEEYITTSKQSL-EEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDA 487
E KR E+ +T K++L EE + E ++ E + + ++E+ ++L Q + A
Sbjct: 1167 ELRAKR----EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAKA 1220
Query: 488 RIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMD---- 543
+D+ + + ++ A++ ++ V G+ + +KK + V ++ K D
Sbjct: 1221 NLDKNKQTLEKENADLAGELR------VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274
Query: 544 -AIIVDSEKTGRDCIQYIKEQRGEPE---TFLPLDYL----EVKPTDEKLRELKGAKLVI 595
A + D ++ ++ + E E L D +++ T E L+E KL +
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 596 DVIRYEPPHIKKALQYACGNALVC-DNVEDARRIAFGGHQ----RHKTVALDGTLFQKSG 650
+ + +LQ + N+E R I+ Q + K T+
Sbjct: 1335 STKLRQLEEERNSLQDQLDEEMEAKQNLE--RHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Query: 651 VISGGASDLKAKARRWDEKAV--DKLKEKKERLTEEL------------------KEQMK 690
+++ ++++EKA DKL++ K RL +EL K+Q K
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1452
Query: 691 ------------------AKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQ 732
R EAE R+ +++A L L+ + E+ + + L
Sbjct: 1453 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-A 1511
Query: 733 EKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREF 792
E L S + G ++++++ ++ E +M+++K ++ ++EDE+ + + +R
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL--QATEDAKLRLEVNM 1569
Query: 793 EEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKL 852
+ K + + ++ + + E ++ +L QL + +L++++ + + KK E +++ L
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1629
Query: 853 KKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEI-------RKKLGGANKEM 905
+ + +K +E + QL+ L+ Q + E+ D +EI KK ++
Sbjct: 1630 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1689
Query: 906 THLQKEVTAIETKLEQKRSDRHNLLQAC--------KMQDIKLPLSKGTM---DDISQEE 954
LQ+++ A E +Q ++ L + +QD K L +++ +E+
Sbjct: 1690 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ 1749
Query: 955 GSSQG-EDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQ 1013
G+ + D V + + + + E E K+ A ++++++ L+ KL+E
Sbjct: 1750 GNMEAMSDRVRKATQQAEQLSNELATERSTAQ-----KNESARQQLERQNKELRSKLHEM 1804
Query: 1014 QSVLQ-----RIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKER 1066
+ ++ IAA K + E V + +E ++ +++ KK K+ Q++ ER
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1862
Score = 122 bits (305), Expect = 3e-27
Identities = 204/1070 (19%), Positives = 437/1070 (40%), Gaps = 196/1070 (18%)
Query: 86 EEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKAR------NFLVFQGA 139
EE A + + + K+ ++++ + + + +L K L++ R N +
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 140 VESIAMKNPKERTALFE---EISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAER 196
+++ K + + E + + + QE +K K+ K E D + + ++ A+
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR---KLEGDASDFHEQIADLQAQI 1078
Query: 197 KE-----AKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEK 251
E AK+E+E RL DE+ AQ L K+ E I L ++L S+ K
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEI--AQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 252 DKKRMDKVEDELKEKKKELGKMM------------REQQ------QIEKEIKEKDSELNQ 293
+K+ + +EL+ K EL + REQ+ +++E + ++++ +
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Query: 294 KRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDM-----------DELEKEMLS 342
R ++ +A E + ++++ + AK +L ++ +K D+ E+E +
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 343 VEKARQEFEERME--EESQSQGRDLTLE-ENQVKKYHRLKEEASKRAATLAQELEKFNRD 399
+E QE + + E ++++ D + +N+V+ + EA +A LA+++ +
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 400 QKADQDRLDLEERKKVETEAKIKQKLRE-------IEENQKRIEKLEEYITTSKQSLEEQ 452
+ Q+ L E R+K+ K++Q E ++E + + LE +I+T L +
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 453 KKLEGELTEEVEMAKRRIDEINKELNQVMEQLGD--ARIDRQESSRQQRKAEIMESIKRL 510
KK + VE + KE+ + +Q + A D+ E ++ + + E+ + +
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV--- 1433
Query: 511 YPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETF 570
+DL N ++ + EK R Q + E++ +
Sbjct: 1434 ---------VDL-----------------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1467
Query: 571 LP-LDYLEVKPTDEKLRELKGAKLVIDVI--RYEPPHIKKALQYACGNALVCDNVEDARR 627
D E + +++ + L A+ + + + + E K L+ A + D V
Sbjct: 1468 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-----AEMEDLVSSKDD 1522
Query: 628 IAFGGHQRHKTV-ALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELK 686
+ H+ K+ AL+ + + + +L+A E A +L+ + L + +
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT-----EDAKLRLEVNMQALKGQFE 1577
Query: 687 EQMKAK--RKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANF 744
++A+ + E + RQ+Q Q H + L+ ++ K R LA K KLE +L +
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELE------DERKQRALAA--AAKKKLEGDLKDL 1629
Query: 745 GPRINDIKRIIQSREREMKDLKEKMNQVED-------------EVF------EEFCREIG 785
+ + I+ RE +K L++ Q++D E+F E+ + +
Sbjct: 1630 ELQADSA---IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686
Query: 786 VRNIREFEE----EKVKRQNEIAKKRLEFE------------NQKTRLGIQLDFEKNQLK 829
++ E+ E+ ++Q ++ K+ L E ++K RL ++ + +L+
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746
Query: 830 EDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNH 889
E+Q + V+K + E+L E + + Q L+ Q+ E+ K H
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN----KELRSKLH 1802
Query: 890 EME-EIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMD 948
EME ++ K + L+ ++ +E ++EQ+ ++ ++ K +D KL
Sbjct: 1803 EMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL-------- 1851
Query: 949 DISQEEGSSQGEDSVSGSQRISSIYAREALIEI-DYGDLCEDLKDAQAEEEIKQEMNTLQ 1007
+E L+++ D + E K+ QAE+ + L+
Sbjct: 1852 --------------------------KEILLQVEDERKMAEQYKE-QAEKG-NARVKQLK 1883
Query: 1008 QKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQ 1057
++L E + QRI A K +L+ + + E A + + ++ +
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 112 bits (281), Expect = 2e-24
Identities = 165/812 (20%), Positives = 341/812 (41%), Gaps = 106/812 (13%)
Query: 137 QGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDT-----------QFN 185
+ V+ + K+ + L E++ + DK K+ + K D Q
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 186 YHRKKNIAAERKEAKQEKEEADRYQ-RLKDEVVRAQVQLQLFKLYHNEVEIE--KLNKEL 242
H+KK + A+ +E + + + +R + L D+V + Q +++ NE E + KL K++
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 243 ASKNKEIE----------KDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELN 292
AS + +++ + K + +L+E++ L + E+ + ++ ++ S LN
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 293 QKRPQYIKAKENTSHKIKKLEAAKKSLQ----NAQKHYKKRKGDMDELEKEMLSVEKARQ 348
+ K ++ + ++ LE KK Q N + Y+++ D+LEK
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT--------- 1421
Query: 349 EFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLD 408
+ R+++E DL +NQ + L+++ K LA+E + + ++DR +
Sbjct: 1422 --KNRLQQELDDLVVDL---DNQRQLVSNLEKKQRKFDQLLAEE-KNISSKYADERDRAE 1475
Query: 409 LEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKR 468
E R+K + + L E E ++ +E+ + + + L K G+ E+E +KR
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 469 RIDEINKELNQVMEQLGDARIDRQESSRQQRKAEI-MESIKRLYPGSVYGRLIDLCQPTQ 527
++ +E+ +E+L D + Q + + + E+ M+++K +
Sbjct: 1536 ALETQMEEMKTQLEELED---ELQATEDAKLRLEVNMQALKGQFE--------------- 1577
Query: 528 KKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRE 587
+++ A +E+ R + + E E E L + +
Sbjct: 1578 ------------RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 588 LKGAKLVID-VIRYEPPHIKKALQYACGNALVCDNVEDARR-----IAFGGHQRHKTVAL 641
LK +L D I+ IK+ + +EDAR A K +L
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1685
Query: 642 DGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRK-EAELRQ 700
+ L Q DL A E+A + +KE L EEL + + + E R+
Sbjct: 1686 EADLMQLQ-------EDLAAA-----ERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 701 VQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSRER 760
++++ L+ L+ Q ++E R + Q+ +L +ELA + Q ER
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDR-VRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 761 EMKDLKEKMNQVEDEVFEEFCREIGV--RNIREFEE--EKVKRQNEIAKKRLEFENQKTR 816
+ K+L+ K++++E V +F I I + EE E+ R+ + A K L+ +++K +
Sbjct: 1793 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1852
Query: 817 -LGIQLDFEKN---QLKEDQDK----VHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMA 868
+ +Q++ E+ Q KE +K V ++ +++ E E +++ ++ + +DE
Sbjct: 1853 EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1912
Query: 869 QLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGG 900
+ + + A KS++ N ++ GG
Sbjct: 1913 SNEAMGREVNALKSKLRRGNETSFVPSRRSGG 1944
Score = 79.0 bits (193), Expect = 3e-14
Identities = 90/469 (19%), Positives = 191/469 (40%), Gaps = 62/469 (13%)
Query: 80 VSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGA 139
+S Y++E DR A + + + + E EELE+ ++KA
Sbjct: 1463 ISSKYADE--RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE-------- 1512
Query: 140 VESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEA 199
+E + + E L + ++ K ++ + E++ Q K + +
Sbjct: 1513 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1572
Query: 200 KQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASK-NKEIEKDKKRMDK 258
K + E + + ++E R Q+Q QL + Y E+E E+ + LA+ K++E D K ++
Sbjct: 1573 KGQFERDLQARDEQNEEKRRQLQRQLHE-YETELEDERKQRALAAAAKKKLEGDLKDLEL 1631
Query: 259 VEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKS 318
D + ++E K +R+ Q K+ + + + R + + K K LEA
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 319 LQN----AQKHYKKRKGDMDELEKEMLSVEKARQEFEE----------RMEEESQSQGRD 364
LQ A++ K+ + +EL +E+ S R ++ ++EEE + + +
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751
Query: 365 LTLEENQVKKYHRLKEEASKRAAT----------LAQELEKFNRDQKAD----------- 403
+ ++V+K + E+ S AT Q+LE+ N++ ++
Sbjct: 1752 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1811
Query: 404 ---------------QDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQS 448
+++++ E R+K +KQK ++++E ++E + K+
Sbjct: 1812 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1871
Query: 449 LEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQ 497
E+ +L ++E A+ IN ++ +L +A + R+
Sbjct: 1872 AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920
Score = 64.3 bits (155), Expect = 7e-10
Identities = 89/410 (21%), Positives = 178/410 (43%), Gaps = 62/410 (15%)
Query: 113 QLHEYSEELE----KLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGEL-AQE 167
QLHEY ELE + + A+ L +G ++ + ++ E I + +L AQ
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKL--EGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Query: 168 YD-KRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLF 226
D +R+ E +A D F A+ E K + EAD Q +D + + Q
Sbjct: 1655 KDFQRELEDARASRDEIF-------ATAKENEKKAKSLEADLMQLQEDLAAAERARKQA- 1706
Query: 227 KLYHNEVEIEKLNKELASK---NKEIEKDKKRMD----KVEDELKEKKKELGKMMREQQQ 279
++E E+L +ELAS ++ +K+R++ ++E+EL+E E G M +
Sbjct: 1707 -----DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE---EQGNMEAMSDR 1758
Query: 280 IEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKE 339
+ K ++ + N+ + A++N S + ++LE K L++ K ++ + +
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESAR-QQLERQNKELRS--KLHEMEGAVKSKFKST 1815
Query: 340 MLSVEKARQEFEERMEEES---QSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKF 396
+ ++E + EE++E+E+ Q+ + L ++ ++K+ E+ K A ++ EK
Sbjct: 1816 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 1875
Query: 397 NRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLE 456
N A++KQ R++EE ++ +++ ++ L+E +
Sbjct: 1876 N---------------------ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1914
Query: 457 GELTEEVEMAKRRIDEINKELNQVMEQLGDARI----DRQESSRQQRKAE 502
+ EV K ++ N+ + G R+ D E R A+
Sbjct: 1915 EAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDAD 1964
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 133 bits (334), Expect = 1e-30
Identities = 199/921 (21%), Positives = 392/921 (42%), Gaps = 119/921 (12%)
Query: 224 QLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKK------ELGKMMREQ 277
+LF +++ + +E+ +K E++K K+R K E+ELKE ++ E +++EQ
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 278 QQIEKEIKEKDSELNQKRPQYIKAKENTSHKIK-KLEAAKKSLQNAQKHYKKRKGDMDEL 336
Q E E+ + E+ + + E H+++ +LE + Q Q KK M +L
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 337 EKEMLSVEKARQEFE-ERMEEESQSQGRD-----LTLEENQVKKYHRLKEE-ASKRAATL 389
E+++ E ARQ+ + E++ E++ + + + + N++ K +L EE S L
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 390 AQELEKFNRDQKAD----------QDRLDLEERKKVETEAKIKQKL--------REIEEN 431
A+E EK K + RL EE+ + E E K+K+KL +I +
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADL 1081
Query: 432 QKRIEKLEEYITTSKQSLEEQ-KKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARID 490
Q +I +L+ + ++ L+ +L+ E+ ++ A ++I E+ ++ + E L R
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQK-NNALKKIRELEGHISDLQEDLDSERAA 1140
Query: 491 RQESSRQQRK-AEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAV-TKVLGKNMDAIIVD 548
R ++ +Q+R E +E++K ++ +++ ++ V K L + +
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200
Query: 549 SEKTGRDCIQYIKEQRGEPETF--LPLDYLEVKPTDEKLR-ELKGAKLVIDVIRYEPPHI 605
++ + Q ++E + E F + + K T EK +L G V+ + E H
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 606 KKALQYACGN-ALVCDNVEDAR-RIAFGGHQ-RHKTVALDGTLFQKSGVISGGASDLKAK 662
KK L+ C + E AR + H+ +++ ++ G L + G A D+ +
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 663 ARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQT 722
+ +L++ +E L EE ++++ K LRQ++ + + LQ Q D E
Sbjct: 1321 S--------SQLQDTQELLQEETRQKLNVSTK---LRQLEEERNSLQ-----DQLDEE-- 1362
Query: 723 KTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCR 782
++ K LE ++ +++D K+ +Q ++ L+E + + E
Sbjct: 1363 --------MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE------- 1407
Query: 783 EIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTV 842
+ N+ + EEK +++ K + + + L + LD ++ + + K ++Q +
Sbjct: 1408 ---IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 843 KKDENEIEKLKKEEQRHMKIIDETMAQLQDLK---NQHLAKKSEVNDKNH----EMEEIR 895
+++N K E R E + L + L K E+ N EME++
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 896 KKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNL---LQACKMQDIKLPLSKGTMDDISQ 952
K + L+K A+ET++E+ ++ L LQA +D KL L Q
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA--TEDAKLRLEVNMQALKGQ 1582
Query: 953 EEGSSQGEDSVSGSQR-------------ISSIYAREALIEIDYGDLCEDLKDAQ----- 994
E Q D + +R + + AL L DLKD +
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 995 ----AEEEIKQ------EMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDE 1044
EE IKQ +M Q++L + ++ I A + +K +S+ + ++
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 1045 FEAARKRAKKAKQAFEQIKKE 1065
AA + K+A E++ +E
Sbjct: 1703 LAAAERARKQADLEKEELAEE 1723
Score = 130 bits (328), Expect = 6e-30
Identities = 208/1018 (20%), Positives = 436/1018 (42%), Gaps = 131/1018 (12%)
Query: 149 KERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAE---RKEAKQEKEE 205
KE +++ L QE + + E+ E+ + KK E EA+ E+EE
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 206 ADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNK-EIEK--DKKRMDKVEDE 262
DR Q+L+ E R ++ Q+ L E+L +E A++ K ++EK + ++ K+EDE
Sbjct: 943 -DRGQQLQAE--RKKMAQQMLDLE------EQLEEEEAARQKLQLEKVTAEAKIKKLEDE 993
Query: 263 LKEKKKELGKMMREQQQIEKEIKEKDSEL---NQKRPQYIKAKENTSHKIKKLEAA---- 315
+ + K+ +E++ +E+ I + + L +K K K I +LE
Sbjct: 994 ILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE 1053
Query: 316 KKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERM---EEESQSQ----GRDLTLE 368
+KS Q +K +K +GD + +++ ++ E + ++ EEE Q+ ++ +
Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113
Query: 369 ENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREI 428
N +KK L+ S L E N+ +K +D + E K E E + +
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1173
Query: 429 EENQKRIEKLEEYITTSKQSL-EEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDA 487
E KR E+ +T K++L EE + E ++ E + + ++E+ ++L Q + A
Sbjct: 1174 ELRAKR----EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAKA 1227
Query: 488 RIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMD---- 543
+D+ + + ++ A++ ++ V G+ + +KK + V ++ K D
Sbjct: 1228 NLDKNKQTLEKENADLAGELR------VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281
Query: 544 -AIIVDSEKTGRDCIQYIKEQRGEPE---TFLPLDYL----EVKPTDEKLRELKGAKLVI 595
A + D ++ ++ + E E L D +++ T E L+E KL +
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 596 DVIRYEPPHIKKALQYACGNALVC-DNVEDARRIAFGGHQ----RHKTVALDGTLFQKSG 650
+ + +LQ + N+E R I+ Q + K T+
Sbjct: 1342 STKLRQLEEERNSLQDQLDEEMEAKQNLE--RHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Query: 651 VISGGASDLKAKARRWDEKAV--DKLKEKKERLTEEL------------------KEQMK 690
+++ ++++EKA DKL++ K RL +EL K+Q K
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1459
Query: 691 ------------------AKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQ 732
R EAE R+ +++A L L+ + E+ + + L
Sbjct: 1460 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-A 1518
Query: 733 EKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREF 792
E L S + G ++++++ ++ E +M+++K ++ ++EDE+ + + +R
Sbjct: 1519 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL--QATEDAKLRLEVNM 1576
Query: 793 EEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKL 852
+ K + + ++ + + E ++ +L QL + +L++++ + + KK E +++ L
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1636
Query: 853 KKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEI-------RKKLGGANKEM 905
+ + +K +E + QL+ L+ Q + E+ D +EI KK ++
Sbjct: 1637 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1696
Query: 906 THLQKEVTAIETKLEQKRSDRHNLLQAC--------KMQDIKLPLSKGTM---DDISQEE 954
LQ+++ A E +Q ++ L + +QD K L +++ +E+
Sbjct: 1697 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ 1756
Query: 955 GSSQG-EDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQ 1013
G+ + D V + + + + E E K+ A ++++++ L+ KL+E
Sbjct: 1757 GNMEAMSDRVRKATQQAEQLSNELATERSTAQ-----KNESARQQLERQNKELRSKLHEM 1811
Query: 1014 QSVLQ-----RIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKER 1066
+ ++ IAA K + E V + +E ++ +++ KK K+ Q++ ER
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1869
Score = 122 bits (305), Expect = 3e-27
Identities = 204/1070 (19%), Positives = 437/1070 (40%), Gaps = 196/1070 (18%)
Query: 86 EEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKAR------NFLVFQGA 139
EE A + + + K+ ++++ + + + +L K L++ R N +
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 140 VESIAMKNPKERTALFE---EISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAER 196
+++ K + + E + + + QE +K K+ K E D + + ++ A+
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR---KLEGDASDFHEQIADLQAQI 1085
Query: 197 KE-----AKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEK 251
E AK+E+E RL DE+ AQ L K+ E I L ++L S+ K
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEI--AQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143
Query: 252 DKKRMDKVEDELKEKKKELGKMM------------REQQ------QIEKEIKEKDSELNQ 293
+K+ + +EL+ K EL + REQ+ +++E + ++++ +
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 294 KRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDM-----------DELEKEMLS 342
R ++ +A E + ++++ + AK +L ++ +K D+ E+E +
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 343 VEKARQEFEERME--EESQSQGRDLTLE-ENQVKKYHRLKEEASKRAATLAQELEKFNRD 399
+E QE + + E ++++ D + +N+V+ + EA +A LA+++ +
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 400 QKADQDRLDLEERKKVETEAKIKQKLRE-------IEENQKRIEKLEEYITTSKQSLEEQ 452
+ Q+ L E R+K+ K++Q E ++E + + LE +I+T L +
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 453 KKLEGELTEEVEMAKRRIDEINKELNQVMEQLGD--ARIDRQESSRQQRKAEIMESIKRL 510
KK + VE + KE+ + +Q + A D+ E ++ + + E+ + +
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV--- 1440
Query: 511 YPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETF 570
+DL N ++ + EK R Q + E++ +
Sbjct: 1441 ---------VDL-----------------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1474
Query: 571 LP-LDYLEVKPTDEKLRELKGAKLVIDVI--RYEPPHIKKALQYACGNALVCDNVEDARR 627
D E + +++ + L A+ + + + + E K L+ A + D V
Sbjct: 1475 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-----AEMEDLVSSKDD 1529
Query: 628 IAFGGHQRHKTV-ALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELK 686
+ H+ K+ AL+ + + + +L+A E A +L+ + L + +
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT-----EDAKLRLEVNMQALKGQFE 1584
Query: 687 EQMKAK--RKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANF 744
++A+ + E + RQ+Q Q H + L+ ++ K R LA K KLE +L +
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELE------DERKQRALAA--AAKKKLEGDLKDL 1636
Query: 745 GPRINDIKRIIQSREREMKDLKEKMNQVED-------------EVF------EEFCREIG 785
+ + I+ RE +K L++ Q++D E+F E+ + +
Sbjct: 1637 ELQADSA---IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693
Query: 786 VRNIREFEE----EKVKRQNEIAKKRLEFE------------NQKTRLGIQLDFEKNQLK 829
++ E+ E+ ++Q ++ K+ L E ++K RL ++ + +L+
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753
Query: 830 EDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNH 889
E+Q + V+K + E+L E + + Q L+ Q+ E+ K H
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN----KELRSKLH 1809
Query: 890 EME-EIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMD 948
EME ++ K + L+ ++ +E ++EQ+ ++ ++ K +D KL
Sbjct: 1810 EMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL-------- 1858
Query: 949 DISQEEGSSQGEDSVSGSQRISSIYAREALIEI-DYGDLCEDLKDAQAEEEIKQEMNTLQ 1007
+E L+++ D + E K+ QAE+ + L+
Sbjct: 1859 --------------------------KEILLQVEDERKMAEQYKE-QAEKG-NARVKQLK 1890
Query: 1008 QKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQ 1057
++L E + QRI A K +L+ + + E A + + ++ +
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 112 bits (281), Expect = 2e-24
Identities = 165/812 (20%), Positives = 341/812 (41%), Gaps = 106/812 (13%)
Query: 137 QGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDT-----------QFN 185
+ V+ + K+ + L E++ + DK K+ + K D Q
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 186 YHRKKNIAAERKEAKQEKEEADRYQ-RLKDEVVRAQVQLQLFKLYHNEVEIE--KLNKEL 242
H+KK + A+ +E + + + +R + L D+V + Q +++ NE E + KL K++
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 243 ASKNKEIE----------KDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELN 292
AS + +++ + K + +L+E++ L + E+ + ++ ++ S LN
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1377
Query: 293 QKRPQYIKAKENTSHKIKKLEAAKKSLQ----NAQKHYKKRKGDMDELEKEMLSVEKARQ 348
+ K ++ + ++ LE KK Q N + Y+++ D+LEK
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT--------- 1428
Query: 349 EFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLD 408
+ R+++E DL +NQ + L+++ K LA+E + + ++DR +
Sbjct: 1429 --KNRLQQELDDLVVDL---DNQRQLVSNLEKKQRKFDQLLAEE-KNISSKYADERDRAE 1482
Query: 409 LEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKR 468
E R+K + + L E E ++ +E+ + + + L K G+ E+E +KR
Sbjct: 1483 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 469 RIDEINKELNQVMEQLGDARIDRQESSRQQRKAEI-MESIKRLYPGSVYGRLIDLCQPTQ 527
++ +E+ +E+L D + Q + + + E+ M+++K +
Sbjct: 1543 ALETQMEEMKTQLEELED---ELQATEDAKLRLEVNMQALKGQFE--------------- 1584
Query: 528 KKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRE 587
+++ A +E+ R + + E E E L + +
Sbjct: 1585 ------------RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 588 LKGAKLVID-VIRYEPPHIKKALQYACGNALVCDNVEDARR-----IAFGGHQRHKTVAL 641
LK +L D I+ IK+ + +EDAR A K +L
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1692
Query: 642 DGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRK-EAELRQ 700
+ L Q DL A E+A + +KE L EEL + + + E R+
Sbjct: 1693 EADLMQLQ-------EDLAAA-----ERARKQADLEKEELAEELASSLSGRNALQDEKRR 1740
Query: 701 VQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSRER 760
++++ L+ L+ Q ++E R + Q+ +L +ELA + Q ER
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDR-VRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 761 EMKDLKEKMNQVEDEVFEEFCREIGV--RNIREFEE--EKVKRQNEIAKKRLEFENQKTR 816
+ K+L+ K++++E V +F I I + EE E+ R+ + A K L+ +++K +
Sbjct: 1800 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1859
Query: 817 -LGIQLDFEKN---QLKEDQDK----VHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMA 868
+ +Q++ E+ Q KE +K V ++ +++ E E +++ ++ + +DE
Sbjct: 1860 EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1919
Query: 869 QLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGG 900
+ + + A KS++ N ++ GG
Sbjct: 1920 SNEAMGREVNALKSKLRRGNETSFVPSRRSGG 1951
Score = 79.0 bits (193), Expect = 3e-14
Identities = 90/469 (19%), Positives = 191/469 (40%), Gaps = 62/469 (13%)
Query: 80 VSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGA 139
+S Y++E DR A + + + + E EELE+ ++KA
Sbjct: 1470 ISSKYADE--RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE-------- 1519
Query: 140 VESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEA 199
+E + + E L + ++ K ++ + E++ Q K + +
Sbjct: 1520 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1579
Query: 200 KQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASK-NKEIEKDKKRMDK 258
K + E + + ++E R Q+Q QL + Y E+E E+ + LA+ K++E D K ++
Sbjct: 1580 KGQFERDLQARDEQNEEKRRQLQRQLHE-YETELEDERKQRALAAAAKKKLEGDLKDLEL 1638
Query: 259 VEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKS 318
D + ++E K +R+ Q K+ + + + R + + K K LEA
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 319 LQN----AQKHYKKRKGDMDELEKEMLSVEKARQEFEE----------RMEEESQSQGRD 364
LQ A++ K+ + +EL +E+ S R ++ ++EEE + + +
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758
Query: 365 LTLEENQVKKYHRLKEEASKRAAT----------LAQELEKFNRDQKAD----------- 403
+ ++V+K + E+ S AT Q+LE+ N++ ++
Sbjct: 1759 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1818
Query: 404 ---------------QDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQS 448
+++++ E R+K +KQK ++++E ++E + K+
Sbjct: 1819 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1878
Query: 449 LEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQ 497
E+ +L ++E A+ IN ++ +L +A + R+
Sbjct: 1879 AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927
Score = 64.3 bits (155), Expect = 7e-10
Identities = 89/410 (21%), Positives = 178/410 (43%), Gaps = 62/410 (15%)
Query: 113 QLHEYSEELE----KLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGEL-AQE 167
QLHEY ELE + + A+ L +G ++ + ++ E I + +L AQ
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKL--EGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Query: 168 YD-KRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLF 226
D +R+ E +A D F A+ E K + EAD Q +D + + Q
Sbjct: 1662 KDFQRELEDARASRDEIF-------ATAKENEKKAKSLEADLMQLQEDLAAAERARKQA- 1713
Query: 227 KLYHNEVEIEKLNKELASK---NKEIEKDKKRMD----KVEDELKEKKKELGKMMREQQQ 279
++E E+L +ELAS ++ +K+R++ ++E+EL+E E G M +
Sbjct: 1714 -----DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE---EQGNMEAMSDR 1765
Query: 280 IEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKE 339
+ K ++ + N+ + A++N S + ++LE K L++ K ++ + +
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESAR-QQLERQNKELRS--KLHEMEGAVKSKFKST 1822
Query: 340 MLSVEKARQEFEERMEEES---QSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKF 396
+ ++E + EE++E+E+ Q+ + L ++ ++K+ E+ K A ++ EK
Sbjct: 1823 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 1882
Query: 397 NRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLE 456
N A++KQ R++EE ++ +++ ++ L+E +
Sbjct: 1883 N---------------------ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1921
Query: 457 GELTEEVEMAKRRIDEINKELNQVMEQLGDARI----DRQESSRQQRKAE 502
+ EV K ++ N+ + G R+ D E R A+
Sbjct: 1922 EAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDAD 1971
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 133 bits (334), Expect = 1e-30
Identities = 199/921 (21%), Positives = 392/921 (42%), Gaps = 119/921 (12%)
Query: 224 QLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKK------ELGKMMREQ 277
+LF +++ + +E+ +K E++K K+R K E+ELKE ++ E +++EQ
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 278 QQIEKEIKEKDSELNQKRPQYIKAKENTSHKIK-KLEAAKKSLQNAQKHYKKRKGDMDEL 336
Q E E+ + E+ + + E H+++ +LE + Q Q KK M +L
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 337 EKEMLSVEKARQEFE-ERMEEESQSQGRD-----LTLEENQVKKYHRLKEE-ASKRAATL 389
E+++ E ARQ+ + E++ E++ + + + + N++ K +L EE S L
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 390 AQELEKFNRDQKAD----------QDRLDLEERKKVETEAKIKQKL--------REIEEN 431
A+E EK K + RL EE+ + E E K+K+KL +I +
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADL 1081
Query: 432 QKRIEKLEEYITTSKQSLEEQ-KKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARID 490
Q +I +L+ + ++ L+ +L+ E+ ++ A ++I E+ ++ + E L R
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQK-NNALKKIRELEGHISDLQEDLDSERAA 1140
Query: 491 RQESSRQQRK-AEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAV-TKVLGKNMDAIIVD 548
R ++ +Q+R E +E++K ++ +++ ++ V K L + +
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200
Query: 549 SEKTGRDCIQYIKEQRGEPETF--LPLDYLEVKPTDEKLR-ELKGAKLVIDVIRYEPPHI 605
++ + Q ++E + E F + + K T EK +L G V+ + E H
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 606 KKALQYACGN-ALVCDNVEDAR-RIAFGGHQ-RHKTVALDGTLFQKSGVISGGASDLKAK 662
KK L+ C + E AR + H+ +++ ++ G L + G A D+ +
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 663 ARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQT 722
+ +L++ +E L EE ++++ K LRQ++ + + LQ Q D E
Sbjct: 1321 S--------SQLQDTQELLQEETRQKLNVSTK---LRQLEEERNSLQ-----DQLDEE-- 1362
Query: 723 KTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCR 782
++ K LE ++ +++D K+ +Q ++ L+E + + E
Sbjct: 1363 --------MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE------- 1407
Query: 783 EIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTV 842
+ N+ + EEK +++ K + + + L + LD ++ + + K ++Q +
Sbjct: 1408 ---IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 843 KKDENEIEKLKKEEQRHMKIIDETMAQLQDLK---NQHLAKKSEVNDKNH----EMEEIR 895
+++N K E R E + L + L K E+ N EME++
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 896 KKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNL---LQACKMQDIKLPLSKGTMDDISQ 952
K + L+K A+ET++E+ ++ L LQA +D KL L Q
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA--TEDAKLRLEVNMQALKGQ 1582
Query: 953 EEGSSQGEDSVSGSQR-------------ISSIYAREALIEIDYGDLCEDLKDAQ----- 994
E Q D + +R + + AL L DLKD +
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 995 ----AEEEIKQ------EMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDE 1044
EE IKQ +M Q++L + ++ I A + +K +S+ + ++
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 1045 FEAARKRAKKAKQAFEQIKKE 1065
AA + K+A E++ +E
Sbjct: 1703 LAAAERARKQADLEKEELAEE 1723
Score = 130 bits (328), Expect = 6e-30
Identities = 208/1018 (20%), Positives = 436/1018 (42%), Gaps = 131/1018 (12%)
Query: 149 KERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAE---RKEAKQEKEE 205
KE +++ L QE + + E+ E+ + KK E EA+ E+EE
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 206 ADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNK-EIEK--DKKRMDKVEDE 262
DR Q+L+ E R ++ Q+ L E+L +E A++ K ++EK + ++ K+EDE
Sbjct: 943 -DRGQQLQAE--RKKMAQQMLDLE------EQLEEEEAARQKLQLEKVTAEAKIKKLEDE 993
Query: 263 LKEKKKELGKMMREQQQIEKEIKEKDSEL---NQKRPQYIKAKENTSHKIKKLEAA---- 315
+ + K+ +E++ +E+ I + + L +K K K I +LE
Sbjct: 994 ILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE 1053
Query: 316 KKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERM---EEESQSQ----GRDLTLE 368
+KS Q +K +K +GD + +++ ++ E + ++ EEE Q+ ++ +
Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113
Query: 369 ENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREI 428
N +KK L+ S L E N+ +K +D + E K E E + +
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1173
Query: 429 EENQKRIEKLEEYITTSKQSL-EEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDA 487
E KR E+ +T K++L EE + E ++ E + + ++E+ ++L Q + A
Sbjct: 1174 ELRAKR----EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAKA 1227
Query: 488 RIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMD---- 543
+D+ + + ++ A++ ++ V G+ + +KK + V ++ K D
Sbjct: 1228 NLDKNKQTLEKENADLAGELR------VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281
Query: 544 -AIIVDSEKTGRDCIQYIKEQRGEPE---TFLPLDYL----EVKPTDEKLRELKGAKLVI 595
A + D ++ ++ + E E L D +++ T E L+E KL +
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 596 DVIRYEPPHIKKALQYACGNALVC-DNVEDARRIAFGGHQ----RHKTVALDGTLFQKSG 650
+ + +LQ + N+E R I+ Q + K T+
Sbjct: 1342 STKLRQLEEERNSLQDQLDEEMEAKQNLE--RHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Query: 651 VISGGASDLKAKARRWDEKAV--DKLKEKKERLTEEL------------------KEQMK 690
+++ ++++EKA DKL++ K RL +EL K+Q K
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1459
Query: 691 ------------------AKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQ 732
R EAE R+ +++A L L+ + E+ + + L
Sbjct: 1460 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-A 1518
Query: 733 EKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREF 792
E L S + G ++++++ ++ E +M+++K ++ ++EDE+ + + +R
Sbjct: 1519 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL--QATEDAKLRLEVNM 1576
Query: 793 EEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKL 852
+ K + + ++ + + E ++ +L QL + +L++++ + + KK E +++ L
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1636
Query: 853 KKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEI-------RKKLGGANKEM 905
+ + +K +E + QL+ L+ Q + E+ D +EI KK ++
Sbjct: 1637 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1696
Query: 906 THLQKEVTAIETKLEQKRSDRHNLLQAC--------KMQDIKLPLSKGTM---DDISQEE 954
LQ+++ A E +Q ++ L + +QD K L +++ +E+
Sbjct: 1697 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ 1756
Query: 955 GSSQG-EDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQ 1013
G+ + D V + + + + E E K+ A ++++++ L+ KL+E
Sbjct: 1757 GNMEAMSDRVRKATQQAEQLSNELATERSTAQ-----KNESARQQLERQNKELRSKLHEM 1811
Query: 1014 QSVLQ-----RIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKER 1066
+ ++ IAA K + E V + +E ++ +++ KK K+ Q++ ER
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1869
Score = 121 bits (304), Expect = 4e-27
Identities = 199/1030 (19%), Positives = 429/1030 (41%), Gaps = 168/1030 (16%)
Query: 86 EEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKAR------NFLVFQGA 139
EE A + + + K+ ++++ + + + +L K L++ R N +
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 140 VESIAMKNPKERTALFE---EISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAER 196
+++ K + + E + + + QE +K K+ K E D + + ++ A+
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR---KLEGDASDFHEQIADLQAQI 1085
Query: 197 KE-----AKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEK 251
E AK+E+E RL DE+ AQ L K+ E I L ++L S+ K
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEI--AQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143
Query: 252 DKKRMDKVEDELKEKKKELGKMM------------REQQ------QIEKEIKEKDSELNQ 293
+K+ + +EL+ K EL + REQ+ +++E + ++++ +
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 294 KRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDM-----------DELEKEMLS 342
R ++ +A E + ++++ + AK +L ++ +K D+ E+E +
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 343 VEKARQEFEERME--EESQSQGRDLTLE-ENQVKKYHRLKEEASKRAATLAQELEKFNRD 399
+E QE + + E ++++ D + +N+V+ + EA +A LA+++ +
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 400 QKADQDRLDLEERKKVETEAKIKQKLRE-------IEENQKRIEKLEEYITTSKQSLEEQ 452
+ Q+ L E R+K+ K++Q E ++E + + LE +I+T L +
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 453 KKLEGELTEEVEMAKRRIDEINKELNQVMEQLGD--ARIDRQESSRQQRKAEIMESIKRL 510
KK + VE + KE+ + +Q + A D+ E ++ + + E+ + +
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV--- 1440
Query: 511 YPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETF 570
+DL N ++ + EK R Q + E++ +
Sbjct: 1441 ---------VDL-----------------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1474
Query: 571 LP-LDYLEVKPTDEKLRELKGAKLVIDVI--RYEPPHIKKALQYACGNALVCDNVEDARR 627
D E + +++ + L A+ + + + + E K L+ A + D V
Sbjct: 1475 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-----AEMEDLVSSKDD 1529
Query: 628 IAFGGHQRHKTV-ALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELK 686
+ H+ K+ AL+ + + + +L+A E A +L+ + L + +
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT-----EDAKLRLEVNMQALKGQFE 1584
Query: 687 EQMKAK--RKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANF 744
++A+ + E + RQ+Q Q H + L+ ++ K R LA K KLE +L +
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELE------DERKQRALAA--AAKKKLEGDLKDL 1636
Query: 745 GPRINDIKRIIQSREREMKDLKEKMNQVED-------------EVF------EEFCREIG 785
+ + I+ RE +K L++ Q++D E+F E+ + +
Sbjct: 1637 ELQADSA---IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693
Query: 786 VRNIREFEE----EKVKRQNEIAKKRLEFE------------NQKTRLGIQLDFEKNQLK 829
++ E+ E+ ++Q ++ K+ L E ++K RL ++ + +L+
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753
Query: 830 EDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNH 889
E+Q + V+K + E+L E + + Q L+ Q+ E+ K H
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN----KELRSKLH 1809
Query: 890 EME-EIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMD 948
EME ++ K + L+ ++ +E ++EQ+ ++ ++ K +D KL ++
Sbjct: 1810 EMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866
Query: 949 DISQEEGSSQGEDSVSGSQRISSIYAR-------EALIEIDYGDLCEDLKDA-QAEEEIK 1000
D ++ E + G+ R+ + + I + L +L +A ++ E +
Sbjct: 1867 D-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG 1925
Query: 1001 QEMNTLQQKL 1010
+E+N L+ KL
Sbjct: 1926 REVNALKSKL 1935
Score = 79.0 bits (193), Expect = 3e-14
Identities = 90/469 (19%), Positives = 191/469 (40%), Gaps = 62/469 (13%)
Query: 80 VSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGA 139
+S Y++E DR A + + + + E EELE+ ++KA
Sbjct: 1470 ISSKYADE--RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE-------- 1519
Query: 140 VESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEA 199
+E + + E L + ++ K ++ + E++ Q K + +
Sbjct: 1520 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1579
Query: 200 KQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASK-NKEIEKDKKRMDK 258
K + E + + ++E R Q+Q QL + Y E+E E+ + LA+ K++E D K ++
Sbjct: 1580 KGQFERDLQARDEQNEEKRRQLQRQLHE-YETELEDERKQRALAAAAKKKLEGDLKDLEL 1638
Query: 259 VEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKS 318
D + ++E K +R+ Q K+ + + + R + + K K LEA
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 319 LQN----AQKHYKKRKGDMDELEKEMLSVEKARQEFEE----------RMEEESQSQGRD 364
LQ A++ K+ + +EL +E+ S R ++ ++EEE + + +
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758
Query: 365 LTLEENQVKKYHRLKEEASKRAAT----------LAQELEKFNRDQKAD----------- 403
+ ++V+K + E+ S AT Q+LE+ N++ ++
Sbjct: 1759 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1818
Query: 404 ---------------QDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQS 448
+++++ E R+K +KQK ++++E ++E + K+
Sbjct: 1819 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1878
Query: 449 LEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQ 497
E+ +L ++E A+ IN ++ +L +A + R+
Sbjct: 1879 AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 133 bits (334), Expect = 1e-30
Identities = 199/921 (21%), Positives = 392/921 (42%), Gaps = 119/921 (12%)
Query: 224 QLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKK------ELGKMMREQ 277
+LF +++ + +E+ +K E++K K+R K E+ELKE ++ E +++EQ
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 278 QQIEKEIKEKDSELNQKRPQYIKAKENTSHKIK-KLEAAKKSLQNAQKHYKKRKGDMDEL 336
Q E E+ + E+ + + E H+++ +LE + Q Q KK M +L
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 337 EKEMLSVEKARQEFE-ERMEEESQSQGRD-----LTLEENQVKKYHRLKEE-ASKRAATL 389
E+++ E ARQ+ + E++ E++ + + + + N++ K +L EE S L
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 390 AQELEKFNRDQKAD----------QDRLDLEERKKVETEAKIKQKL--------REIEEN 431
A+E EK K + RL EE+ + E E K+K+KL +I +
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADL 1074
Query: 432 QKRIEKLEEYITTSKQSLEEQ-KKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARID 490
Q +I +L+ + ++ L+ +L+ E+ ++ A ++I E+ ++ + E L R
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQK-NNALKKIRELEGHISDLQEDLDSERAA 1133
Query: 491 RQESSRQQRK-AEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAV-TKVLGKNMDAIIVD 548
R ++ +Q+R E +E++K ++ +++ ++ V K L + +
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193
Query: 549 SEKTGRDCIQYIKEQRGEPETF--LPLDYLEVKPTDEKLR-ELKGAKLVIDVIRYEPPHI 605
++ + Q ++E + E F + + K T EK +L G V+ + E H
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 606 KKALQYACGN-ALVCDNVEDAR-RIAFGGHQ-RHKTVALDGTLFQKSGVISGGASDLKAK 662
KK L+ C + E AR + H+ +++ ++ G L + G A D+ +
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 663 ARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQT 722
+ +L++ +E L EE ++++ K LRQ++ + + LQ Q D E
Sbjct: 1314 S--------SQLQDTQELLQEETRQKLNVSTK---LRQLEEERNSLQ-----DQLDEE-- 1355
Query: 723 KTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCR 782
++ K LE ++ +++D K+ +Q ++ L+E + + E
Sbjct: 1356 --------MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE------- 1400
Query: 783 EIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTV 842
+ N+ + EEK +++ K + + + L + LD ++ + + K ++Q +
Sbjct: 1401 ---IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 843 KKDENEIEKLKKEEQRHMKIIDETMAQLQDLK---NQHLAKKSEVNDKNH----EMEEIR 895
+++N K E R E + L + L K E+ N EME++
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Query: 896 KKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNL---LQACKMQDIKLPLSKGTMDDISQ 952
K + L+K A+ET++E+ ++ L LQA +D KL L Q
Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA--TEDAKLRLEVNMQALKGQ 1575
Query: 953 EEGSSQGEDSVSGSQR-------------ISSIYAREALIEIDYGDLCEDLKDAQ----- 994
E Q D + +R + + AL L DLKD +
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 995 ----AEEEIKQ------EMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDE 1044
EE IKQ +M Q++L + ++ I A + +K +S+ + ++
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 1045 FEAARKRAKKAKQAFEQIKKE 1065
AA + K+A E++ +E
Sbjct: 1696 LAAAERARKQADLEKEELAEE 1716
Score = 130 bits (328), Expect = 6e-30
Identities = 208/1018 (20%), Positives = 436/1018 (42%), Gaps = 131/1018 (12%)
Query: 149 KERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAE---RKEAKQEKEE 205
KE +++ L QE + + E+ E+ + KK E EA+ E+EE
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935
Query: 206 ADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNK-EIEK--DKKRMDKVEDE 262
DR Q+L+ E R ++ Q+ L E+L +E A++ K ++EK + ++ K+EDE
Sbjct: 936 -DRGQQLQAE--RKKMAQQMLDLE------EQLEEEEAARQKLQLEKVTAEAKIKKLEDE 986
Query: 263 LKEKKKELGKMMREQQQIEKEIKEKDSEL---NQKRPQYIKAKENTSHKIKKLEAA---- 315
+ + K+ +E++ +E+ I + + L +K K K I +LE
Sbjct: 987 ILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE 1046
Query: 316 KKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERM---EEESQSQ----GRDLTLE 368
+KS Q +K +K +GD + +++ ++ E + ++ EEE Q+ ++ +
Sbjct: 1047 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106
Query: 369 ENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREI 428
N +KK L+ S L E N+ +K +D + E K E E + +
Sbjct: 1107 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1166
Query: 429 EENQKRIEKLEEYITTSKQSL-EEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDA 487
E KR E+ +T K++L EE + E ++ E + + ++E+ ++L Q + A
Sbjct: 1167 ELRAKR----EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAKA 1220
Query: 488 RIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMD---- 543
+D+ + + ++ A++ ++ V G+ + +KK + V ++ K D
Sbjct: 1221 NLDKNKQTLEKENADLAGELR------VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274
Query: 544 -AIIVDSEKTGRDCIQYIKEQRGEPE---TFLPLDYL----EVKPTDEKLRELKGAKLVI 595
A + D ++ ++ + E E L D +++ T E L+E KL +
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 596 DVIRYEPPHIKKALQYACGNALVC-DNVEDARRIAFGGHQ----RHKTVALDGTLFQKSG 650
+ + +LQ + N+E R I+ Q + K T+
Sbjct: 1335 STKLRQLEEERNSLQDQLDEEMEAKQNLE--RHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Query: 651 VISGGASDLKAKARRWDEKAV--DKLKEKKERLTEEL------------------KEQMK 690
+++ ++++EKA DKL++ K RL +EL K+Q K
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1452
Query: 691 ------------------AKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQ 732
R EAE R+ +++A L L+ + E+ + + L
Sbjct: 1453 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-A 1511
Query: 733 EKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREF 792
E L S + G ++++++ ++ E +M+++K ++ ++EDE+ + + +R
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL--QATEDAKLRLEVNM 1569
Query: 793 EEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKL 852
+ K + + ++ + + E ++ +L QL + +L++++ + + KK E +++ L
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1629
Query: 853 KKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEI-------RKKLGGANKEM 905
+ + +K +E + QL+ L+ Q + E+ D +EI KK ++
Sbjct: 1630 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1689
Query: 906 THLQKEVTAIETKLEQKRSDRHNLLQAC--------KMQDIKLPLSKGTM---DDISQEE 954
LQ+++ A E +Q ++ L + +QD K L +++ +E+
Sbjct: 1690 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ 1749
Query: 955 GSSQG-EDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQ 1013
G+ + D V + + + + E E K+ A ++++++ L+ KL+E
Sbjct: 1750 GNMEAMSDRVRKATQQAEQLSNELATERSTAQ-----KNESARQQLERQNKELRSKLHEM 1804
Query: 1014 QSVLQ-----RIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKER 1066
+ ++ IAA K + E V + +E ++ +++ KK K+ Q++ ER
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1862
Score = 121 bits (304), Expect = 4e-27
Identities = 199/1030 (19%), Positives = 429/1030 (41%), Gaps = 168/1030 (16%)
Query: 86 EEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKAR------NFLVFQGA 139
EE A + + + K+ ++++ + + + +L K L++ R N +
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 140 VESIAMKNPKERTALFE---EISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAER 196
+++ K + + E + + + QE +K K+ K E D + + ++ A+
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR---KLEGDASDFHEQIADLQAQI 1078
Query: 197 KE-----AKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEK 251
E AK+E+E RL DE+ AQ L K+ E I L ++L S+ K
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEI--AQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 252 DKKRMDKVEDELKEKKKELGKMM------------REQQ------QIEKEIKEKDSELNQ 293
+K+ + +EL+ K EL + REQ+ +++E + ++++ +
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Query: 294 KRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDM-----------DELEKEMLS 342
R ++ +A E + ++++ + AK +L ++ +K D+ E+E +
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 343 VEKARQEFEERME--EESQSQGRDLTLE-ENQVKKYHRLKEEASKRAATLAQELEKFNRD 399
+E QE + + E ++++ D + +N+V+ + EA +A LA+++ +
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 400 QKADQDRLDLEERKKVETEAKIKQKLRE-------IEENQKRIEKLEEYITTSKQSLEEQ 452
+ Q+ L E R+K+ K++Q E ++E + + LE +I+T L +
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 453 KKLEGELTEEVEMAKRRIDEINKELNQVMEQLGD--ARIDRQESSRQQRKAEIMESIKRL 510
KK + VE + KE+ + +Q + A D+ E ++ + + E+ + +
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV--- 1433
Query: 511 YPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETF 570
+DL N ++ + EK R Q + E++ +
Sbjct: 1434 ---------VDL-----------------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1467
Query: 571 LP-LDYLEVKPTDEKLRELKGAKLVIDVI--RYEPPHIKKALQYACGNALVCDNVEDARR 627
D E + +++ + L A+ + + + + E K L+ A + D V
Sbjct: 1468 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-----AEMEDLVSSKDD 1522
Query: 628 IAFGGHQRHKTV-ALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELK 686
+ H+ K+ AL+ + + + +L+A E A +L+ + L + +
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT-----EDAKLRLEVNMQALKGQFE 1577
Query: 687 EQMKAK--RKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANF 744
++A+ + E + RQ+Q Q H + L+ ++ K R LA K KLE +L +
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELE------DERKQRALAA--AAKKKLEGDLKDL 1629
Query: 745 GPRINDIKRIIQSREREMKDLKEKMNQVED-------------EVF------EEFCREIG 785
+ + I+ RE +K L++ Q++D E+F E+ + +
Sbjct: 1630 ELQADSA---IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686
Query: 786 VRNIREFEE----EKVKRQNEIAKKRLEFE------------NQKTRLGIQLDFEKNQLK 829
++ E+ E+ ++Q ++ K+ L E ++K RL ++ + +L+
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746
Query: 830 EDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNH 889
E+Q + V+K + E+L E + + Q L+ Q+ E+ K H
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN----KELRSKLH 1802
Query: 890 EME-EIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMD 948
EME ++ K + L+ ++ +E ++EQ+ ++ ++ K +D KL ++
Sbjct: 1803 EMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859
Query: 949 DISQEEGSSQGEDSVSGSQRISSIYAR-------EALIEIDYGDLCEDLKDA-QAEEEIK 1000
D ++ E + G+ R+ + + I + L +L +A ++ E +
Sbjct: 1860 D-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG 1918
Query: 1001 QEMNTLQQKL 1010
+E+N L+ KL
Sbjct: 1919 REVNALKSKL 1928
Score = 79.0 bits (193), Expect = 3e-14
Identities = 90/469 (19%), Positives = 191/469 (40%), Gaps = 62/469 (13%)
Query: 80 VSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGA 139
+S Y++E DR A + + + + E EELE+ ++KA
Sbjct: 1463 ISSKYADE--RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE-------- 1512
Query: 140 VESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEA 199
+E + + E L + ++ K ++ + E++ Q K + +
Sbjct: 1513 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1572
Query: 200 KQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASK-NKEIEKDKKRMDK 258
K + E + + ++E R Q+Q QL + Y E+E E+ + LA+ K++E D K ++
Sbjct: 1573 KGQFERDLQARDEQNEEKRRQLQRQLHE-YETELEDERKQRALAAAAKKKLEGDLKDLEL 1631
Query: 259 VEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKS 318
D + ++E K +R+ Q K+ + + + R + + K K LEA
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 319 LQN----AQKHYKKRKGDMDELEKEMLSVEKARQEFEE----------RMEEESQSQGRD 364
LQ A++ K+ + +EL +E+ S R ++ ++EEE + + +
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751
Query: 365 LTLEENQVKKYHRLKEEASKRAAT----------LAQELEKFNRDQKAD----------- 403
+ ++V+K + E+ S AT Q+LE+ N++ ++
Sbjct: 1752 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1811
Query: 404 ---------------QDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQS 448
+++++ E R+K +KQK ++++E ++E + K+
Sbjct: 1812 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1871
Query: 449 LEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQ 497
E+ +L ++E A+ IN ++ +L +A + R+
Sbjct: 1872 AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 132 bits (331), Expect = 3e-30
Identities = 191/936 (20%), Positives = 422/936 (45%), Gaps = 99/936 (10%)
Query: 163 ELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAER--------KEAKQEKEEADRYQRLKD 214
EL ++ D + + K E++ ++ KN+ E K K++K + +Q+ D
Sbjct: 949 ELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1008
Query: 215 EVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKK-RMD------KVEDELKEKK 267
++ + ++ + ++ KL +++ +E++KK RMD K+E +LK +
Sbjct: 1009 DLQAEEDKVNTL----TKAKV-KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063
Query: 268 KELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYK 327
+ + + ++QQ+++ +K+KD ELN + + S KKL+ + ++ ++ +
Sbjct: 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 1123
Query: 328 KRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLK---EEASK 384
+ ++EK + + +E ER+EE + + + + + ++ +++ EEA+
Sbjct: 1124 AERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATL 1183
Query: 385 RAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITT 444
+ A L K + D A E ++++ ++KQKL E E+++ ++E L++ +
Sbjct: 1184 QHEATAAALRKKHADSVA-------ELGEQIDNLQRVKQKL-EKEKSEFKLE-LDDVTSN 1234
Query: 445 SKQSLEEQKKLE---GELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQ-QRK 500
+Q ++ + LE L +++ + + +E + +N + Q + + E SRQ K
Sbjct: 1235 MEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEK 1294
Query: 501 AEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYI 560
++ + R G+L Q K Q+ +V KN A + S + DC +
Sbjct: 1295 EALISQLTR-------GKLTYTQQLEDLKRQLE-EEVKAKNALAHALQSAR--HDC-DLL 1343
Query: 561 KEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCD 620
+EQ E ET E K +++ +++ +YE I++ + +
Sbjct: 1344 REQY-EEET-------EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1395
Query: 621 NVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLK---AKARRWDEKA--VDKLK 675
+++A + K +L+ T + I D++ A A D+K DK+
Sbjct: 1396 RLQEAEEAVEAVNA--KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKIL 1453
Query: 676 EKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEK- 734
+ ++ EE + ++++ +KEA R + ++ L+ + S LE K + NLQE+
Sbjct: 1454 AEWKQKYEESQSELESSQKEA--RSLSTELFKLKNAYEESLEHLETFKREN--KNLQEEI 1509
Query: 735 SKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEE 794
S L +L + G I++++++ + E E +L+ + + E + E + + R EF +
Sbjct: 1510 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKIL--RAQLEFNQ 1567
Query: 795 EKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKK 854
K + + ++A+K E E K +D + L + + + KK E ++ +++
Sbjct: 1568 IKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEI 1627
Query: 855 EEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTA 914
+ ++ E Q++ L++ + +++D +++++ + + LQ E+
Sbjct: 1628 QLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEE 1687
Query: 915 IETKLEQKRSDR----------HNLLQACKMQDIKLPLSKGTMD-DISQEEGSSQGEDSV 963
+ +EQ R +Q Q+ L K MD D+SQ + ++ E++V
Sbjct: 1688 LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQ--TEVEEAV 1745
Query: 964 SGSQRISSIYAREALIEIDYGDLCEDLKDAQ--------AEEEIKQEMNTLQQKLNEQQS 1015
R + A++A+ D + E+LK Q ++ ++Q + LQ +L+E +
Sbjct: 1746 Q-ECRNAEEKAKKAI--TDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQ 1802
Query: 1016 VLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKR 1051
+ + K ++KLE+ + +E +E EA +KR
Sbjct: 1803 IALK---GGKKQLQKLEA---RVRELENELEAEQKR 1832
Score = 121 bits (304), Expect = 4e-27
Identities = 210/1009 (20%), Positives = 435/1009 (43%), Gaps = 173/1009 (17%)
Query: 197 KEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNK-----EIEK 251
K A++EKE A +K+E R + L+ + E+E EK+ L KN + E+
Sbjct: 841 KSAEREKEMAS----MKEEFTRLKEALEKSEARRKELE-EKMVSLLQEKNDLQLQVQAEQ 895
Query: 252 D-----KKRMDKV---EDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKE 303
D ++R D++ + +L+ K KE+ + + +++++ E+ K +L + + + +
Sbjct: 896 DNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDID 955
Query: 304 NTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGR 363
+ + K+E K + +N K+ + +DE+ ++ +KA QE ++ ++ Q++
Sbjct: 956 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED 1015
Query: 364 DL-TLEENQVKKYHRLK--EEASKRAATLAQELEKFNRDQKAD------------QDRLD 408
+ TL + +VK ++ E + ++ + +LE+ R + D D+
Sbjct: 1016 KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQ 1075
Query: 409 LEERKK------------VETEAKIKQKL-REIEENQKRIEKLEEYITTSKQSLEEQKKL 455
L+ER K +E E + +L ++++E Q RIE+LEE + + + + +KL
Sbjct: 1076 LDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKL 1135
Query: 456 EGELTEEVEMAKRRIDE------INKELNQVME-QLGDARIDRQESSRQQRKAEIMESIK 508
+L+ E+E R++E + E+N+ E + R D +E++ Q K
Sbjct: 1136 RSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK 1195
Query: 509 RLYPGSVYGRLIDLCQPTQKKYQIAVTKV------LGKNMDAII---VDSEKTGRDCIQY 559
+ G ID Q ++K + ++ + NM+ II + EK R
Sbjct: 1196 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQ 1255
Query: 560 IKEQRGEPE-------------TFLPLDYLEV-KPTDEK---LRELKGAKLVI-----DV 597
+ E R + E L + E+ + DEK + +L KL D+
Sbjct: 1256 MNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDL 1315
Query: 598 IRY--EPPHIKKALQYACGNAL-VCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISG 654
R E K AL +A +A CD + + +T A + V+S
Sbjct: 1316 KRQLEEEVKAKNALAHALQSARHDCDLLRE--------QYEEETEA----KAELQRVLSK 1363
Query: 655 GASDLKAKARRWDEKAV---DKLKEKKERLTEELKEQMKA-KRKEAELRQVQSQAHGLQM 710
S++ +++ A+ ++L+E K++L + L+E +A + A+ ++ H LQ
Sbjct: 1364 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQN 1423
Query: 711 RLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMN 770
++ D+E++ AL+ ++++ + LA + + + + ++S ++E + L ++
Sbjct: 1424 EIEDLMVDVERSNAAAAALDKKQRN-FDKILAEWKQKYEESQSELESSQKEARSLSTELF 1482
Query: 771 QVED------EVFEEFCRE--------------IGVRNIREFEEEKVKRQNEIAKKRLEF 810
++++ E E F RE +G E EKV++Q E K L+
Sbjct: 1483 KLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQS 1542
Query: 811 ENQKTRLGIQLDFEK---NQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETM 867
++ ++ + K QL+ +Q K + + +KDE E+E+ K+ H++++D
Sbjct: 1543 ALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDE-EMEQAKR---NHLRVVDSLQ 1598
Query: 868 AQLQ---DLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRS 924
L +N+ L K ++ +EME +L AN+ QK+V ++++ L
Sbjct: 1599 TSLDAETRSRNEALRVKKKMEGDLNEME---IQLSHANRMAAEAQKQVKSLQSLL----- 1650
Query: 925 DRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYG 984
K I+L + DD+ + I+ + R L++ +
Sbjct: 1651 ---------KDTQIQLDDAVRANDDL---------------KENIAIVERRNNLLQAELE 1686
Query: 985 DLCEDLKDAQ-----AEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQ 1039
+L ++ + AE+E+ + +Q ++ S++ + + + V + Q
Sbjct: 1687 ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ 1746
Query: 1040 ETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKAL 1088
E + E A+K A E++KKE+ +A E + N+++ K L
Sbjct: 1747 ECRNAEEKAKKAITDAAMMAEELKKEQ--DTSAHLERMKKNMEQTIKDL 1793
Score = 81.3 bits (199), Expect = 5e-15
Identities = 101/456 (22%), Positives = 207/456 (45%), Gaps = 47/456 (10%)
Query: 660 KAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDL 719
+A+ + +EK V L+EK + + EQ E Q+ L+ ++K L
Sbjct: 867 EARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERL 926
Query: 720 EQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEV--F 777
E + + L +K KLE E + I+D++ + E+E + K+ + +E+
Sbjct: 927 EDEEEMNAELT-AKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 985
Query: 778 EEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHM 837
+E ++ E++ ++ ++ A L+ E K L K +L++ D +
Sbjct: 986 DEIIAKL------TKEKKALQEAHQQALDDLQAEEDKVN---TLTKAKVKLEQQVDDLEG 1036
Query: 838 WEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQ---HLAKKS-EVNDKNHEMEE 893
+ KK ++E+ K++ + +K+ E++ L++ K Q L KK E+N N +E+
Sbjct: 1037 SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIED 1096
Query: 894 IRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQE 953
+ K++ LQ + +E +LE +R+ R K++ ++ LS+ +++IS+
Sbjct: 1097 EQALGSQLQKKLKELQARIEELEEELEAERTAR------AKVEKLRSDLSR-ELEEISER 1149
Query: 954 EGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEE-----IKQEMNTLQQ 1008
+ G SV +I REA ++ + DL++A + E ++++
Sbjct: 1150 LEEAGGATSV----QIEMNKKREA----EFQKMRRDLEEATLQHEATAAALRKKHADSVA 1201
Query: 1009 KLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFD 1068
+L EQ LQR+ +KLE + +F+ D+ + ++ KAK E++ + D
Sbjct: 1202 ELGEQIDNLQRV-------KQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED 1254
Query: 1069 RFNACFESVATNIDEIYKALSRNSSAQAFLGPENPE 1104
+ N + +E ++++ +S +A L EN E
Sbjct: 1255 QMN----EHRSKAEETQRSVNDLTSQRAKLQTENGE 1286
Score = 74.3 bits (181), Expect = 7e-13
Identities = 89/423 (21%), Positives = 188/423 (44%), Gaps = 59/423 (13%)
Query: 685 LKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQ------------ 732
L E+M+ +R + ++Q+Q+ G+ R++Y + + + N++
Sbjct: 772 LLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMK 831
Query: 733 ---------EKSKLESELANFGPRINDIKRIIQSREREMKDLKEKM-------NQVEDEV 776
+ ++ E E+A+ +K ++ E K+L+EKM N ++ +V
Sbjct: 832 LYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQV 891
Query: 777 ---------FEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQ 827
EE C ++ I+ E KVK NE + E + T +L+ E ++
Sbjct: 892 QAEQDNLADAEERCDQLIKNKIQL--EAKVKEMNERLEDEEEMNAELTAKKRKLEDECSE 949
Query: 828 LKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQL-QDLKNQHLAKKSEVND 886
LK D D + + V+K+++ E K M +DE +A+L ++ K A + ++D
Sbjct: 950 LKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDD 1009
Query: 887 KNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGT 946
E + K+ K L+++V +E LEQ++ R +L +A + + L L++ +
Sbjct: 1010 LQAEED----KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 1065
Query: 947 MDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAE-EEIKQEM-- 1003
+ D+ ++ E ++++ AR + L + LK+ QA EE+++E+
Sbjct: 1066 IMDLENDK-QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA 1124
Query: 1004 -NTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQI 1062
T + K+ + +S L R +LE + ++ +E + KK + F+++
Sbjct: 1125 ERTARAKVEKLRSDLSR----------ELEEISERLEEAGGATSVQIEMNKKREAEFQKM 1174
Query: 1063 KKE 1065
+++
Sbjct: 1175 RRD 1177
Score = 62.0 bits (149), Expect = 3e-09
Identities = 83/412 (20%), Positives = 176/412 (42%), Gaps = 42/412 (10%)
Query: 120 ELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAE 179
ELEK+ ++A + Q A+E E + ++ E +++ E +
Sbjct: 1525 ELEKVRKQLEAEK-MELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEM 1583
Query: 180 EDTQFNYHRKKNIAAERKEAK-QEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKL 238
E + N+ R + +A+ + + EA R ++ K E ++++QL E +K
Sbjct: 1584 EQAKRNHLRVVDSLQTSLDAETRSRNEALRVKK-KMEGDLNEMEIQLSHANRMAAEAQKQ 1642
Query: 239 NKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQ-KRPQ 297
K L S K+ + + D+LKE + + R ++ E++E + + Q +R +
Sbjct: 1643 VKSLQSLLKDTQIQLDDAVRANDDLKEN---IAIVERRNNLLQAELEELRAVVEQTERSR 1699
Query: 298 YIKAKE--NTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEER-- 353
+ +E TS +++ L + SL N +K K D+ +L+ E+ + + EE+
Sbjct: 1700 KLAEQELIETSERVQLLHSQNTSLINQKK---KMDADLSQLQTEVEEAVQECRNAEEKAK 1756
Query: 354 -------MEEESQSQGRDLTLEENQVKK---------YHRLKEEASKRAATLAQELEKFN 397
M E + +D + ++KK HRL E ++L+K
Sbjct: 1757 KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLE 1816
Query: 398 RDQKADQDRLDLEERKKVET-------EAKIKQKLREIEENQKRIEKLEEYITTSKQSLE 450
+ ++ L+ E+++ E+ E +IK+ + EE++K + +L++ + + ++
Sbjct: 1817 ARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVK 1876
Query: 451 EQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAE 502
K+ E E+ + ++ EL++ E R D ES + +A+
Sbjct: 1877 AYKRQAEEAEEQANTNLSKFRKVQHELDEAEE-----RADIAESQVNKLRAK 1923
Score = 49.3 bits (116), Expect = 2e-05
Identities = 42/203 (20%), Positives = 96/203 (47%), Gaps = 11/203 (5%)
Query: 163 ELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQ 222
+L E ++ +E AEE KK I A++ K+E D L E ++ ++
Sbjct: 1736 QLQTEVEEAVQECRNAEEKA------KKAITDAAMMAEELKKEQDTSAHL--ERMKKNME 1787
Query: 223 LQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEK 282
+ L H E E++ L K+++K + R+ ++E+EL+ ++K + ++ ++ E+
Sbjct: 1788 QTIKDLQHRLDEAEQI--ALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSER 1845
Query: 283 EIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLS 342
IKE + + R ++ ++ K++A K+ + A++ +++ E+
Sbjct: 1846 RIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDE 1905
Query: 343 VEKARQEFEERMEEESQSQGRDL 365
E+ R + E + +++ RD+
Sbjct: 1906 AEE-RADIAESQVNKLRAKSRDI 1927
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 131 bits (330), Expect = 3e-30
Identities = 202/1004 (20%), Positives = 438/1004 (43%), Gaps = 126/1004 (12%)
Query: 160 RSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEAD-RYQRLKDEVVR 218
+S E +E K+E + +E + + R+K + + QEK + + Q +D +
Sbjct: 843 KSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLND 902
Query: 219 AQVQLQLFKLYHNEVEIEKLNKELASKNKEIEK------DKKRMDKVEDELKEKKKELGK 272
A+ + +L N++++E KE+ + ++ E+ KKR K+EDE E KK++
Sbjct: 903 AEERCD--QLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKR--KLEDECSELKKDIDD 958
Query: 273 MMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGD 332
+ ++EKE ++++ + E + K+ +A +++ Q A + +
Sbjct: 959 LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDK 1018
Query: 333 MDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQE 392
++ L K + +E+ + E +E+E + + DL + +++ +L +E + + E
Sbjct: 1019 VNSLSKSKVKLEQQVDDLEGSLEQEKKVR-MDLERAKRKLEGDLKLTQE-----SIMDLE 1072
Query: 393 LEKFNRDQKADQDRLDL-EERKKVETEAKIKQKL-REIEENQKRIEKLEEYITTSKQSLE 450
+K ++K + D+ ++ K+E E + +L ++++ENQ RIE+LEE + + +
Sbjct: 1073 NDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARA 1132
Query: 451 EQKKLEGELTEEVEMAKRRIDE------INKELNQVME-QLGDARIDRQESSRQQRKAEI 503
+ +KL +L+ E+E R++E + E+N+ E + R D +E++ Q
Sbjct: 1133 KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1192
Query: 504 MESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKV------LGKNMDAII---VDSEKTGR 554
K + G ID Q ++K + ++ + NM+ II + EK R
Sbjct: 1193 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSR 1252
Query: 555 DCIQYIKEQRGEPE-------TFLPLDYLEVKPTDEKLRELKGAKLVIDVI-------RY 600
E R + E F E R+L+ + +I +
Sbjct: 1253 TLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQ 1312
Query: 601 EPPHIKKALQY--ACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASD 658
+ +K+ L+ NAL ++ AR ++++ Q+ V+S S+
Sbjct: 1313 QMEDLKRQLEEEGKAKNAL-AHALQSARHDCDLLREQYEEETEAKAELQR--VLSKANSE 1369
Query: 659 LKAKARRWDEKAV---DKLKEKKERLTEELKEQMKA-KRKEAELRQVQSQAHGLQMRLKY 714
+ +++ A+ ++L+E K++L + L++ +A + A+ ++ H LQ ++
Sbjct: 1370 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED 1429
Query: 715 SQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVED 774
D+E++ AL+ ++++ + LA + + + + ++S ++E + L ++ ++++
Sbjct: 1430 LMVDVERSNAAAAALDKKQRN-FDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKN 1488
Query: 775 ------EVFEEFCRE----------------IGVRNIREFEEEKVKRQNEIAKKRLEFEN 812
E E F RE G +N+ E EKV++Q E+ K L+
Sbjct: 1489 AYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHEL--EKVRKQLEVEKLELQSAL 1546
Query: 813 QKTRLGIQLDFEK---NQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQ 869
++ ++ + K QL+ +Q K + + +KDE E+E+ K+ QR + + ++
Sbjct: 1547 EEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDE-EMEQAKRNHQRVVDSLQTSLDA 1605
Query: 870 LQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNL 929
+N+ L K ++ +EME +L AN+ QK+V ++++ L
Sbjct: 1606 ETRSRNEVLRVKKKMEGDLNEME---IQLSHANRMAAEAQKQVKSLQSLL---------- 1652
Query: 930 LQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCED 989
K I+L + DD+ + I+ + R L++ + +L
Sbjct: 1653 ----KDTQIQLDDAVRANDDL---------------KENIAIVERRNNLLQAELEELRAV 1693
Query: 990 LKDAQ-----AEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDE 1044
++ + AE+E+ + +Q ++ S++ + + V + QE +
Sbjct: 1694 VEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNA 1753
Query: 1045 FEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKAL 1088
E A+K A E++KKE+ +A E + N+++ K L
Sbjct: 1754 EEKAKKAITDAAMMAEELKKEQ--DTSAHLERMKKNMEQTIKDL 1795
Score = 113 bits (283), Expect = 1e-24
Identities = 196/1030 (19%), Positives = 435/1030 (42%), Gaps = 171/1030 (16%)
Query: 149 KERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKN-----IAAERKEAKQEK 203
KE + EE R E ++ + R+KE+ E+ + ++KN + AE+ +
Sbjct: 849 KEMATMKEEFGRIKETLEKSEARRKEL----EEKMVSLLQEKNDLQLQVQAEQDNLNDAE 904
Query: 204 EEADRY---------------QRLKDEV-VRAQVQLQLFKLYHN-----------EVEIE 236
E D+ +RL+DE + A++ + KL E+ +
Sbjct: 905 ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLA 964
Query: 237 KLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRP 296
K+ KE + +++ + M +++ + + KE + QQ +++ ++ ++N
Sbjct: 965 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSK 1024
Query: 297 QYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERME- 355
+K ++ LE KK + ++ +K +GD+ ++ ++ +E + + EE+++
Sbjct: 1025 SKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKK 1084
Query: 356 ------------EESQSQGRDL--TLEENQVK----------------KYHRLKEEASKR 385
E+ Q L L+ENQ + K +L+ + S+
Sbjct: 1085 KEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRE 1144
Query: 386 AATLAQELE----------KFNRDQKAD--QDRLDLEE-------------RKKVETEAK 420
+++ LE + N+ ++A+ + R DLEE +K ++ A+
Sbjct: 1145 LEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE 1204
Query: 421 IKQKLREIEENQKRIEK--------LEEYITTSKQSLEEQKKLE---GELTEEVEMAKRR 469
+ +++ ++ ++++EK L++ + +Q ++ + LE L ++ + +
Sbjct: 1205 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVK 1264
Query: 470 IDEINKELNQVMEQLGDARIDRQESSRQ-QRKAEIMESIKRLYPGSVYGRLIDLCQPTQK 528
++E + LN Q + + E +RQ + K ++ + R G+L Q
Sbjct: 1265 LEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTR-------GKLSYTQQMEDL 1317
Query: 529 KYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLREL 588
K Q+ + GK +A+ + DC ++EQ E ET E K +++
Sbjct: 1318 KRQL---EEEGKAKNALAHALQSARHDC-DLLREQY-EEET-------EAKAELQRVLSK 1365
Query: 589 KGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQK 648
+++ +YE I++ + + ++DA + K +L+ T +
Sbjct: 1366 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNA--KCSSLEKTKHRL 1423
Query: 649 SGVISGGASDLK---AKARRWDEKA--VDKLKEKKERLTEELKEQMKAKRKEAELRQVQS 703
I D++ A A D+K DK+ + ++ EE + ++++ +KEA R + +
Sbjct: 1424 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEA--RSLST 1481
Query: 704 QAHGLQMRLKYSQSDLEQTKTRHLALNLQEK-SKLESELANFGPRINDIKRIIQSREREM 762
+ L+ + S LE K + NLQE+ S L +L G +++++++ + E E
Sbjct: 1482 ELFKLKNAYEESLEHLETFKREN--KNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEK 1539
Query: 763 KDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLD 822
+L+ + + E + E + + R EF + K + + ++A+K E E K +D
Sbjct: 1540 LELQSALEEAEASLEHEEGKIL--RAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVD 1597
Query: 823 FEKNQLKED---QDKVHMWEQTVKKDENEIE-------KLKKEEQRHMK----IIDETMA 868
+ L + +++V ++ ++ D NE+E ++ E Q+ +K ++ +T
Sbjct: 1598 SLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQI 1657
Query: 869 QLQDL--KNQHLAKKSEVNDKNH-----EMEEIRKKLGGANKEMTHLQKEVTAIETKLEQ 921
QL D N L + + ++ + E+EE+R + + ++E+ +++
Sbjct: 1658 QLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQL 1717
Query: 922 KRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEI 981
S +L+ K + L + +++ QE E+ + +++ A E E
Sbjct: 1718 LHSQNTSLINQKKKMESDLTQLQSEVEEAVQE--CRNAEEKAKKAITDAAMMAEELKKEQ 1775
Query: 982 DYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQET 1041
D E +K + ++Q + LQ +L+E + + + K ++KLE+ + +E
Sbjct: 1776 DTSAHLERMK-----KNMEQTIKDLQHRLDEAEQIALK---GGKKQLQKLEA---RVREL 1824
Query: 1042 SDEFEAARKR 1051
E EA +KR
Sbjct: 1825 EGELEAEQKR 1834
Score = 104 bits (259), Expect = 6e-22
Identities = 211/1064 (19%), Positives = 443/1064 (41%), Gaps = 149/1064 (14%)
Query: 86 EEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAM 145
E AE R + SE K + ++L E EK K +N ++ I
Sbjct: 933 EMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIA 992
Query: 146 KNPKERTALFEEISRS-GELAQEYDK---RKKEMVKAEE---DTQFNYHRKKNIAAERKE 198
K KE+ AL E ++ +L E DK K VK E+ D + + ++K + + +
Sbjct: 993 KLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLER 1052
Query: 199 AKQEKE-EADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKN-------KEIE 250
AK++ E + Q ++ ++QL+ KL E +I + N ++ + K+++
Sbjct: 1053 AKRKLEGDLKLTQESIMDLENDKLQLEE-KLKKKEFDINQQNSKIEDEQVLALQLQKKLK 1111
Query: 251 KDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDS-------------ELNQKRP- 296
+++ R++++E+EL+ ++ K+ + + + +E++E E+N+KR
Sbjct: 1112 ENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREA 1171
Query: 297 QYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGD-MDELEKEMLSVEKARQEFEERME 355
++ K + + + EA +L+ G+ +D L++ +EK + EF+ ++
Sbjct: 1172 EFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELD 1231
Query: 356 EESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEE---- 411
+ + + + + + N K L+++A++ L +E ++ D + +L E
Sbjct: 1232 DVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKL-EEAQRSLNDFTTQRAKLQTENGELA 1290
Query: 412 RKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRID 471
R+ E EA I Q R +++E L K+ LEE+ K + L ++ A+ D
Sbjct: 1291 RQLEEKEALISQLTRGKLSYTQQMEDL-------KRQLEEEGKAKNALAHALQSARHDCD 1343
Query: 472 ----------EINKELNQVMEQLGDARID---RQESSRQQRKAEIMESIKRLYPGSVYGR 518
E EL +V+ + + E+ QR E+ E+ K+L R
Sbjct: 1344 LLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ-----R 1398
Query: 519 LIDLCQPTQ----KKYQIAVTKV-LGKNMDAIIVDSEKTGRDCIQYIKEQRG-------- 565
L D + + K + TK L ++ ++VD E++ K+QR
Sbjct: 1399 LQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEW 1458
Query: 566 -----EPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCD 620
E ++ L E + +L +LK A YE ++ + N + +
Sbjct: 1459 KQKYEESQSELESSQKEARSLSTELFKLKNA--------YEES-LEHLETFKRENKNLQE 1509
Query: 621 NVED-ARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKE 679
+ D ++ GG H+ + L + + + +A +E + + + +
Sbjct: 1510 EISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEH-EEGKILRAQLEFN 1568
Query: 680 RLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLES 739
++ E++ ++ K +E E QA R+ S +TR L+ K K+E
Sbjct: 1569 QIKAEIERKLAEKDEEME------QAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG 1622
Query: 740 ELANFGPRINDIKRIIQSREREMKD----LKEKMNQVEDEV--FEEFCREIGV----RNI 789
+L +++ R+ ++++K LK+ Q++D V ++ I + N+
Sbjct: 1623 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNL 1682
Query: 790 REFEEEKVK---RQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDE 846
+ E E+++ Q E ++K E E +T +QL +N +Q K + T + E
Sbjct: 1683 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSE 1742
Query: 847 NE--IEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKE 904
E +++ + E++ K I + ++LK + D + +E ++K + K+
Sbjct: 1743 VEEAVQECRNAEEKAKKAITDAAMMAEELKKE--------QDTSAHLERMKKNMEQTIKD 1794
Query: 905 MTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVS 964
+ H E I K +K+ + L+A ++++++ L E + +SV
Sbjct: 1795 LQHRLDEAEQIALKGGKKQLQK---LEA-RVRELEGEL----------EAEQKRNAESVK 1840
Query: 965 GSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPN 1024
G ++ + + E+ Y Q EE+ K+ + LQ +++ Q ++
Sbjct: 1841 GMRK-----SERRIKELTY----------QTEED-KKNLLRLQDLVDKLQLKVKAYKRQA 1884
Query: 1025 MKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFD 1068
+A E+ + KF++ E + A +RA A+ +++ + D
Sbjct: 1885 EEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRD 1928
Score = 93.2 bits (230), Expect = 1e-18
Identities = 171/882 (19%), Positives = 358/882 (40%), Gaps = 116/882 (13%)
Query: 104 EYKINNKVVQLHEYSEELEKLGILIKA--RNFLVFQGAVESIAMKNPKERTALFEEISRS 161
E K+ K +++ + ++E +L + Q +E + + ERTA +
Sbjct: 1079 EEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLR 1138
Query: 162 GELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEA--------------- 206
+L++E ++ + + +A T K AE ++ +++ EEA
Sbjct: 1139 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1198
Query: 207 -----------DRYQRLKD--EVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKD- 252
D QR+K E +++ +L+L + N +I K L ++ +E
Sbjct: 1199 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQA 1258
Query: 253 ---KKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKD---SELNQKRPQYIKAKENTS 306
+ ++++ + L + + K+ E ++ ++++EK+ S+L + + Y + E+
Sbjct: 1259 NEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLK 1318
Query: 307 HKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEE------------RM 354
++++ AK +L +A + + D D L ++ +A+ E + R
Sbjct: 1319 RQLEEEGKAKNALAHA---LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRT 1375
Query: 355 EEESQSQGRDLTLEENQVKKYHRLK--EEASKRAATLAQELEKFNR-------DQKADQD 405
+ E+ + R LEE + K RL+ EEA + LEK D D +
Sbjct: 1376 KYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1435
Query: 406 R-------LDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGE 458
R LD ++R + A+ KQK EE+Q +E ++ + L + K E
Sbjct: 1436 RSNAAAAALDKKQRNFDKILAEWKQKY---EESQSELESSQKEARSLSTELFKLKNAYEE 1492
Query: 459 LTEEVEMAKRRIDEINKELNQVMEQLGDA--RIDRQESSRQQRKAEIMESIKRLYPGSV- 515
E +E KR + +E++ + EQLG+ + E R+Q + E +E L
Sbjct: 1493 SLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEAS 1552
Query: 516 ----YGRLIDLCQPTQKKYQIAVTKVLGKNMDAI---------IVDSEKTGRDCIQYIKE 562
G+++ Q + + + + L + + + +VDS +T D
Sbjct: 1553 LEHEEGKIL-RAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDA------ 1605
Query: 563 QRGEPETFLPLDYLEVKPTDE-KLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDN 621
ET + L VK E L E++ + + E K+LQ + +
Sbjct: 1606 -----ETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQI--Q 1658
Query: 622 VEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERL 681
++DA R + V L Q + ++R+ E+ + + E+ + L
Sbjct: 1659 LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLL 1718
Query: 682 TEELKEQMKAKRK-EAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESE 740
+ + K+K E++L Q+QS+ + ++ ++ T A+ +E K +
Sbjct: 1719 HSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAIT-DAAMMAEELKKEQDT 1777
Query: 741 LANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIG--VRNIREFE---EE 795
A+ ++R+ ++ E+ +KDL+ ++++ E + +++ +RE E E
Sbjct: 1778 SAH-------LERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEA 1830
Query: 796 KVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKE 855
+ KR E K + E + L Q + +K L QD V + VK + + E+ +++
Sbjct: 1831 EQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQ 1890
Query: 856 EQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKK 897
++ + +L + + + +S+VN + +I K
Sbjct: 1891 ANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAK 1932
Score = 85.1 bits (209), Expect = 4e-16
Identities = 105/469 (22%), Positives = 223/469 (47%), Gaps = 60/469 (12%)
Query: 668 EKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQ--SQAHGLQMRLKYSQSDLEQTKTR 725
EK + +KE+ R+ E L E+ +A+RKE E + V + + LQ++++ Q +L + R
Sbjct: 848 EKEMATMKEEFGRIKETL-EKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEER 906
Query: 726 HLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIG 785
L ++ K +LE+++ R+ D + + + + L+++ ++++ ++ +
Sbjct: 907 CDQL-IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAK 965
Query: 786 VRNIREFEEEKVKRQNE--------IAK-----KRLEFENQKTRLGIQLDFEK-NQLKED 831
V + E KVK E IAK K L+ +Q+ +Q++ +K N L +
Sbjct: 966 VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKS 1025
Query: 832 QDKVHMWEQTV-------KKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQ---HLAKK 881
+ K+ + KK ++E+ K++ + +K+ E++ L++ K Q L KK
Sbjct: 1026 KVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKK 1085
Query: 882 S-EVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKL 940
++N +N ++E+ + K++ Q + +E +LE +R+ R K++ ++
Sbjct: 1086 EFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTAR------AKVEKLRS 1139
Query: 941 PLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEE-- 998
LS+ +++IS+ + G SV +I REA ++ + DL++A + E
Sbjct: 1140 DLSR-ELEEISERLEEAGGATSV----QIEMNKKREA----EFQKMRRDLEEATLQHEAT 1190
Query: 999 ---IKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKA 1055
++++ +L EQ LQR+ +KLE + +F+ D+ + ++ KA
Sbjct: 1191 AAALRKKHADSVAELGEQIDNLQRVK-------QKLEKEKSEFKLELDDVTSNMEQIIKA 1243
Query: 1056 KQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPENPE 1104
K E++ + D+ N ++E ++L+ ++ +A L EN E
Sbjct: 1244 KANLEKVSRTLEDQAN----EYRVKLEEAQRSLNDFTTQRAKLQTENGE 1288
Score = 75.5 bits (184), Expect = 3e-13
Identities = 95/428 (22%), Positives = 191/428 (44%), Gaps = 69/428 (16%)
Query: 685 LKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQ------------ 732
L E+M+ +R + ++Q+QA G MR+++ + + + N++
Sbjct: 774 LLEEMRDERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMK 833
Query: 733 ---------EKSKLESELANFGPRINDIKRIIQSREREMKDLKEKM-------NQVEDEV 776
+ ++ E E+A IK ++ E K+L+EKM N ++ +V
Sbjct: 834 LYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQV 893
Query: 777 ---------FEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQ 827
EE C ++ I+ E KVK NE + E + T +L+ E ++
Sbjct: 894 QAEQDNLNDAEERCDQLIKNKIQL--EAKVKEMNERLEDEEEMNAELTAKKRKLEDECSE 951
Query: 828 LKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQL-QDLKNQHLAKKSEVND 886
LK+D D + + V+K+++ E K M +DE +A+L ++ K A + ++D
Sbjct: 952 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDD 1011
Query: 887 KNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGT 946
E + K+ +K L+++V +E LEQ++ R +L +A + + L L++ +
Sbjct: 1012 LQVEED----KVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 1067
Query: 947 M-----DDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAE-EEIK 1000
+ D + EE + E + +Q+ S I + L L + LK+ QA EE++
Sbjct: 1068 IMDLENDKLQLEEKLKKKEFDI--NQQNSKIEDEQVLAL----QLQKKLKENQARIEELE 1121
Query: 1001 QEM---NTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQ 1057
+E+ T + K+ + +S L R +LE + ++ +E + KK +
Sbjct: 1122 EELEAERTARAKVEKLRSDLSR----------ELEEISERLEEAGGATSVQIEMNKKREA 1171
Query: 1058 AFEQIKKE 1065
F++++++
Sbjct: 1172 EFQKMRRD 1179
Score = 68.2 bits (165), Expect = 5e-11
Identities = 93/467 (19%), Positives = 194/467 (41%), Gaps = 70/467 (14%)
Query: 84 YSEEGAEDRTFARVIVGGSSEY-----KINNKVVQLHEYSEELEKLGILIKARNFLVFQG 138
Y EE RV+ +SE K +Q E EE +K K L Q
Sbjct: 1349 YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKK-----KLAQRL--QD 1401
Query: 139 AVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAA--ER 196
A E++ N K +K K + ED + R AA ++
Sbjct: 1402 AEEAVEAVNAK---------------CSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDK 1446
Query: 197 KEAKQEK---EEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDK 253
K+ +K E +Y+ + E+ +Q + + E+ KL + +E K
Sbjct: 1447 KQRNFDKILAEWKQKYEESQSELESSQKEARSLS-----TELFKLKNAYEESLEHLETFK 1501
Query: 254 KRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLE 313
+ +++E+ + ++LG+ + ++EK K+ + E + + +A+ + H+ K+
Sbjct: 1502 RENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKIL 1561
Query: 314 AAKKSLQNAQKHYKKRKGDMD-ELEKEMLSVEKARQEFEERMEEESQSQGR--------- 363
A+ + +++ + D E+E+ + ++ + ++ E++S+
Sbjct: 1562 RAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKME 1621
Query: 364 -DLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKAD--------QDRLDLEERKK 414
DL E Q+ +R+ EA K+ +L Q L K + Q D ++ + + ER+
Sbjct: 1622 GDLNEMEIQLSHANRMAAEAQKQVKSL-QSLLKDTQIQLDDAVRANDDLKENIAIVERRN 1680
Query: 415 VETEAKIKQKLREIEENQKRIEKL--EEYITTSKQ----------SLEEQKKLEGELTEE 462
+A++ ++LR + E +R KL +E I TS++ + ++KK+E +LT+
Sbjct: 1681 NLLQAEL-EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQL 1739
Query: 463 VEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKR 509
+ + E + + + DA + +E ++Q + +E +K+
Sbjct: 1740 QSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1786
Score = 40.4 bits (93), Expect = 0.011
Identities = 37/188 (19%), Positives = 85/188 (45%), Gaps = 11/188 (5%)
Query: 141 ESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAK 200
E A K + + EE+ + + + ++ KK M + +D Q + IA + + +
Sbjct: 1754 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQ 1813
Query: 201 QEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVE-IEKLNKELASKNKEIEKDKKRMDKV 259
+K EA R + L+ E+ Q K V+ + K + + + E+DKK + ++
Sbjct: 1814 LQKLEA-RVRELEGELEAEQ------KRNAESVKGMRKSERRIKELTYQTEEDKKNLLRL 1866
Query: 260 EDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTS---HKIKKLEAAK 316
+D + + + ++ R+ ++ E++ S+ + + + +A+E ++ KL A
Sbjct: 1867 QDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKS 1926
Query: 317 KSLQNAQK 324
+ + QK
Sbjct: 1927 RDIGAKQK 1934
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 129 bits (323), Expect = 2e-29
Identities = 197/965 (20%), Positives = 425/965 (44%), Gaps = 85/965 (8%)
Query: 146 KNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEE 205
+ +E+ L EE + Q + R+KE+ EE+ Q + E ++ QE +E
Sbjct: 803 RQQREQRFLPEEEEKEQRRRQRRE-REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE 861
Query: 206 ADRYQ-RLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELK 264
R Q + +D+ R Q++ + + H L ++L + + ++++++ + + E E K
Sbjct: 862 RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE-K 920
Query: 265 EKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKL----------EA 314
+++E + RE++Q+++E ++ E +KR + + +E K KKL E
Sbjct: 921 RRRQEQERQYREEEQLQQEEEQLLREEREKRRR--QERERQYRKDKKLQQKEEQLLGEEP 978
Query: 315 AKKSLQNAQKHYKKRKGDMDELEKEMLSVEKA---RQEFEE--RMEEESQSQGRDLTLEE 369
K+ Q +K Y++ + ++ + E+++L E+ RQE+E R ++E Q + L EE
Sbjct: 979 EKRRRQEREKKYREEE-ELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037
Query: 370 NQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEE--RKKVETEAKIKQKLRE 427
+ ++ +E + L QE E+ +++ + R +LE RK+ E + + +Q LRE
Sbjct: 1038 REKRRLQE-RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096
Query: 428 IEENQKRIEKLEEYITTSKQSLEEQKKLEGELT----EEVEMAKRRIDEINKELNQVMEQ 483
E ++R E+ + + EE++ L E +E+E R +E+ +E Q++ +
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156
Query: 484 LGDARIDRQESSRQQRKAEIM----------ESIKRLYPGSVYGRLIDLCQPTQKKYQIA 533
+ R RQE RQ R+ E + E KR R + Q ++K +
Sbjct: 1157 EPEKR-RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215
Query: 534 VTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKL 593
+ E RD Y K + E L L + + + L+ L G +
Sbjct: 1216 DEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQ 1275
Query: 594 VIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVIS 653
D + ++ + L + ++A+R + + + + ++
Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335
Query: 654 GGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKR---KEAELRQVQSQAHGL-- 708
+ + + +E+ + + + ++ EEL+ Q + ++ +E LR+ + + L
Sbjct: 1336 RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKE 1395
Query: 709 --QMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLK 766
Q+R + + L Q + R Q+ S+ E + + + ++ ++ +ERE K L+
Sbjct: 1396 EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERD-----RKFREEEQQVRRQERERKFLE 1450
Query: 767 EKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKN 826
E+ Q+ E +F E + ++E EE+++ RQ E +K LE E Q R F +
Sbjct: 1451 EE-QQLRQERHRKFREE--EQLLQEREEQQLHRQ-ERDRKFLEEEQQLRRQERDRKFREQ 1506
Query: 827 QLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVND 886
+L+ + E+ ++E ++ + +QR K + E + + Q ++ + +
Sbjct: 1507 ELRSQEP-----ERKFLEEEQQLHR----QQRQRKFLQEEQQLRRQERGQQ--RRQDRDR 1555
Query: 887 KNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGT 946
K E E++R++ +E L ++ + +LE+++ R + + +L +G
Sbjct: 1556 KFREEEQLRQE-----REEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEG- 1609
Query: 947 MDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCED--LKDAQAEEEIKQEMN 1004
+ QE ED +R R+ E D L E+ L+ + E++++ + +
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQLHRQ---ERDRKFLEEEPQLRRQEREQQLRHDRD 1666
Query: 1005 TLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKK 1064
+K E++ +LQ ++ E+ R++ Q+ ++R +K Q +Q+++
Sbjct: 1667 ---RKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL-----RRQERERKFLQEEQQLRR 1718
Query: 1065 ERFDR 1069
+ +R
Sbjct: 1719 QELER 1723
Score = 119 bits (299), Expect = 1e-26
Identities = 174/947 (18%), Positives = 429/947 (45%), Gaps = 84/947 (8%)
Query: 141 ESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAK 200
E + + P+ + L EE + +L ++ +R+++ EE Q R++ + +++E +
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQ---EEEQQQQRLRREQQLRRKQEEER 314
Query: 201 QEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVE 260
+E++E R Q+ + E + + QL + E+ ++L + +E ++++ + E
Sbjct: 315 REQQEERREQQERREQQEERREQQL-----RREQEERREQQLRREQEEERREQQLRREQE 369
Query: 261 DELKEKKKELGKMMREQQQIEKEIK-EKDSELNQ----KRPQYIKAKENTSHKIKKLEAA 315
+E +E++ + +R +QQ+ +E + ++ +L + +R Q ++ +E + ++L
Sbjct: 370 EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-REQQLRREQQLRRE 428
Query: 316 KKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKY 375
++ ++ QKH ++R+ + E+E R+E ER E+E + Q EE + +++
Sbjct: 429 QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Query: 376 HRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRI 435
+L+EE + ++ E+ + + +Q+ + K+ E E +++Q+LR ++ ++
Sbjct: 489 LKLEEEERR------EQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQ 542
Query: 436 EKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESS 495
E+ E + EE+K+LE E E + KR +E +L + E+ R+ R++
Sbjct: 543 EERREQLL----KREEEKRLEQERRE--QRLKREQEERRDQLLKREEERRQQRLKREQEE 596
Query: 496 RQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRD 555
R +++ + E ++RL + + +P +++ Q ++ E+ R
Sbjct: 597 RLEQRLK-REEVERLEQEERREQRLKREEPEEERRQ------------QLLKSEEQEERR 643
Query: 556 CIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGN 615
Q +EQ+ E L + E + RE + + ++ E ++ ++
Sbjct: 644 QQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703
Query: 616 -ALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKAR----RWDEKA 670
++ DAR+ R ++ G + K + R +W E+
Sbjct: 704 WQWQLESEADARQSKVYSRPR-----------KQEGQRRRQEQEEKRRRRESELQWQEEE 752
Query: 671 VDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGL-QMRLKYSQSDLEQTKTRHLAL 729
++++E + Q +A+ K RQ S L + R + +++ Q + +
Sbjct: 753 RAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRF-- 810
Query: 730 NLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNI 789
L E+ + E R +++ + + + + ++ +++ + ED + E+ R
Sbjct: 811 -LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR 869
Query: 790 R------EFEEEKVKRQNEI-AKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTV 842
R + EEE+ +R++ + AK L+ + +K + +Q + E+ Q +E+++K EQ
Sbjct: 870 RDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQ-REEREKRRRQEQ-- 926
Query: 843 KKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEM--EEIRKKLGG 900
++ E E+L++EE++ ++ +E + + + + K ++ K ++ EE K+
Sbjct: 927 ERQYREEEQLQQEEEQLLR--EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ 984
Query: 901 ANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGE 960
++ ++E+ E +L ++ ++ + Q+ + K D++ QEE E
Sbjct: 985 EREKKYREEEELQQEEEQLLREEREKR------RRQEWERQYRK--KDELQQEEEQLLRE 1036
Query: 961 DSVSGS-QRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQR 1019
+ Q Y E ++ + L + ++ + +E++++ +++L +++ L R
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK-EEELQQEEEQLLR 1095
Query: 1020 IAAPNMKAMEKLESVRDKFQETSDEFEAAR-KRAKKAKQAFEQIKKE 1065
+ E+ R++ + +E + R +R K+ +Q E+ +E
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYRE 1142
Score = 117 bits (292), Expect = 9e-26
Identities = 177/948 (18%), Positives = 430/948 (45%), Gaps = 73/948 (7%)
Query: 141 ESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEA- 199
+ + K +ER EE E ++ ++R+++ ++ E++ + ++ ER+E
Sbjct: 304 QQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQ 363
Query: 200 -KQEKEEADRYQRLK-DEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMD 257
++E+EE R Q+L+ ++ +R + QL+ + E ++L +E + ++ + ++++
Sbjct: 364 LRREQEEERREQQLRREQQLRREQQLRREQQLRRE---QQLRREQQLRREQQLRREQQLR 420
Query: 258 KVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKK 317
+ + +E+++E + EQ++ E+ +K + E R ++K +E T + E K+
Sbjct: 421 REQQLRREQEEERHEQKHEQERREQRLKREQEE----RRDWLKREEETERH--EQERRKQ 474
Query: 318 SLQNAQKHYKKRKG----DMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVK 373
L+ Q+ ++ + + + E++ ++ R+E EER E+ + Q + L++ +++
Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQ-RLR 533
Query: 374 KYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQK 433
+L+ E +R L + E+ +Q+ + RL E+ ++ + K +++ R+ ++
Sbjct: 534 SEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKRE 593
Query: 434 RIEKLEEYITTSK-QSLEEQKKLEGELTEEVEMAKRRIDEINKELNQV--MEQLGDARID 490
+ E+LE+ + + + LE++++ E L E +RR + E + +QL + +
Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653
Query: 491 RQES--SRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVD 548
R+E R++ + + + +KR + R +L + Q++ + + + K + +
Sbjct: 654 RREQRLKREEEEERLEQRLKREHEEE--RREQELAEEEQEQARERIKSRIPKWQWQL--E 709
Query: 549 SEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKA 608
SE R Y + ++ E + + E+ R + ++L E H ++
Sbjct: 710 SEADARQSKVYSRPRKQEGQ--------RRRQEQEEKRRRRESELQWQ--EEERAHRQQQ 759
Query: 609 LQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDE 668
+ E R + K+ L + + L+A+ R+ E
Sbjct: 760 EE------------EQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQRE 807
Query: 669 KAVDKLKEKKERLTEELKEQMKAKR--KEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRH 726
+ +E+KE+ + +E+ K + +E E Q + +A LQ Q D E+ +++
Sbjct: 808 QRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQE 867
Query: 727 LALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGV 786
+ + + +LE E + + + +E + L+E+ +++ E E+ R+
Sbjct: 868 QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE 927
Query: 787 RNIRE-----FEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQT 841
R RE EEE++ R+ ++R E E Q + E+ L E+ +K E+
Sbjct: 928 RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER- 986
Query: 842 VKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGA 901
+K E E+L++EE++ ++ + + Q+ + Q+ K ++ + E R+K
Sbjct: 987 -EKKYREEEELQQEEEQLLR-EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQ 1044
Query: 902 NKEMTHLQKEVTAIETK--LEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQG 959
+E + ++E E + L ++R R + Q+++ K +++ QEE
Sbjct: 1045 ERERQYREEEELQQEEEQLLGEERETR-------RRQELERQYRK--EEELQQEEEQLLR 1095
Query: 960 EDSVSGSQRISSIYAR-EALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQ 1018
E+ ++ R E ++ + L + ++ + +E++++ ++ E++ +L+
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 1019 RIAAPNMKAMEKLE-SVRDKFQETSDEFEAARKRAKKAKQAFEQIKKE 1065
P + ++LE R++ + +E + R+ +K +Q E+ +E
Sbjct: 1156 E--EPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYRE 1201
Score = 115 bits (289), Expect = 2e-25
Identities = 188/966 (19%), Positives = 416/966 (43%), Gaps = 156/966 (16%)
Query: 157 EISRSG--ELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKD 214
E+ R G E Q+ +R+ + + EE+ ++ RK+ ++E K ++EE R + L++
Sbjct: 217 ELRRKGREEKQQQRRERQDRVFQEEEEKEW---RKRETVLRKEEEKLQEEEPQRQRELQE 273
Query: 215 EVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMM 274
E + QL KL E+ E+ +E + + + ++++ K E+E +E+++E +
Sbjct: 274 E------EEQLRKLERQELRRERQEEE--QQQQRLRREQQLRRKQEEERREQQEERREQQ 325
Query: 275 -REQQQIEKEIKEKDSELNQKRPQYIKAK---ENTSHKIKKLEAAKKSLQNAQKHYKKRK 330
R +QQ E+ ++ E ++R Q ++ + E ++++ + ++ Q ++ + R+
Sbjct: 326 ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385
Query: 331 GDMDELEKEMLSVEKARQEFEERMEEE---SQSQGRDLTLEENQVKKYHRLKEEASKRAA 387
E+++ ++ R+E + R E++ Q R+ L Q ++ H K E +R
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE- 444
Query: 388 TLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIE--KLEEYITTS 445
++ R+Q+ +D L EE + + + KQ+L+ +E ++R KLEE
Sbjct: 445 ------QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE----- 493
Query: 446 KQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIME 505
++ E+Q++ E +L E E + + + +E ++ ++L + R+E ++ + E
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553
Query: 506 SIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRG 565
KRL Q++ + + + + D ++ E+ + ++ +E+R
Sbjct: 554 EEKRL---------------EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER- 597
Query: 566 EPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDA 625
LE + E++ L+ + ++ E P ++ Q L + E+
Sbjct: 598 ----------LEQRLKREEVERLEQEERREQRLKREEPEEERRQQ-----LLKSEEQEER 642
Query: 626 RRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEEL 685
R+ Q+ + + + K +E+ +LK + E EE
Sbjct: 643 RQQQLRREQQER-------------------REQRLKREEEEERLEQRLKREHE---EER 680
Query: 686 KEQMKAKRKEAELR------------QVQSQAHGLQMRL----------KYSQSDLEQTK 723
+EQ A+ ++ + R Q++S+A Q ++ + Q E+ +
Sbjct: 681 REQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR 740
Query: 724 TRHLALNLQEKSKL------ESELANFGPRINDIKRIIQSRER-----EMKDLKEKMNQV 772
R L QE+ + E + +F + ++ + R+R +++ +E+ +
Sbjct: 741 RRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRA 800
Query: 773 EDEVFEE--FCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRL-----GIQLDFEK 825
E+ E F E E E+E+ +RQ +K L+F ++ +L QL E+
Sbjct: 801 EERQQREQRFLPE-------EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEE 853
Query: 826 NQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDL-KNQHLAKKSEV 884
+ L+EDQ++ EQ ++D+ +L++E +R + A + L K Q L ++ E
Sbjct: 854 DGLQEDQERRRSQEQ--RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE 911
Query: 885 NDKNHEMEEIRKKLGGAN-KEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLS 943
+ E E+ R++ +E LQ+E + + +KR + Q K D KL
Sbjct: 912 ELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK--DKKL--- 966
Query: 944 KGTMDDISQEEGSSQGED-SVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQE 1002
Q+E GE+ Q Y E ++ + L + ++ + +E +++
Sbjct: 967 -------QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ 1019
Query: 1003 ---MNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAF 1059
+ LQQ+ E+Q + + ++ E+ ++ Q+ ++ + ++ ++
Sbjct: 1020 YRKKDELQQE--EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELE 1077
Query: 1060 EQIKKE 1065
Q +KE
Sbjct: 1078 RQYRKE 1083
Score = 111 bits (278), Expect = 4e-24
Identities = 183/908 (20%), Positives = 398/908 (43%), Gaps = 97/908 (10%)
Query: 157 EISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEA--DRYQRLKD 214
E R EL ++Y RK+E ++ EE+ +K ER+ +E+EE + Q L++
Sbjct: 1069 ETRRRQELERQY--RKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE 1126
Query: 215 EVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEK--DKKRMDKVEDELKEKKKELGK 272
E + + Q +L + Y E E+++ ++L + E + + +R + E+EL++++++L +
Sbjct: 1127 EREKRRRQ-ELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185
Query: 273 MMREQ--QQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRK 330
+E+ Q+ E++ +E++ QKR Q + ++ S + E K++ K Y K +
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGR 1245
Query: 331 GDMD--ELEKEMLSVEKARQEFE---------ERMEEESQSQGRDLTLEENQVKKYHRLK 379
+ +LE L +++Q+ + +R +E + Q RD E + + R +
Sbjct: 1246 ENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEE--QLEREE 1303
Query: 380 EEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQK----LREIEENQKRI 435
++ +KR +QE ++ R+++ ++ R +RK E E ++++ LR E ++K
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR 1363
Query: 436 EKLEEYITTSKQSLEEQKKLEGELTEEV---EMAKRRIDEINKELNQVMEQLGDARIDRQ 492
E+ + ++ LEE+++L + E E + R E ++L Q ++ R + Q
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR--KFREEEQ 1421
Query: 493 ESSRQQRKAEIMESIKRLYPGSVYGRLID----LCQPTQKKYQIAVTKVLGKNMDAIIVD 548
+ SRQ+R + E +++ + ++ L Q +K+ + + ++ +
Sbjct: 1422 QLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKF---------REEEQLLQE 1472
Query: 549 SEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKA 608
E+ Q + Q + + L + D K RE + +R + P K
Sbjct: 1473 REE------QQLHRQERDRKFLEEEQQLRRQERDRKFREQE--------LRSQEPERKF- 1517
Query: 609 LQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDE 668
+E+ +++ QR + + ++ D K R ++
Sbjct: 1518 -------------LEEEQQLH--RQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQ 1562
Query: 669 KAVDKLKEKKERLTEELK---EQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTR 725
++ +++ R + K E+ K +R+E E + ++ + Q+R + Q L Q + R
Sbjct: 1563 LRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQ---QLRRQEGQQQLRQERDR 1619
Query: 726 HLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIG 785
+ Q + E + + R D K + + + ++ ++++ D F E
Sbjct: 1620 KFREDEQLLQEREEQQLHRQER--DRKFLEEEPQLRRQEREQQLRHDRDRKFRE-----E 1672
Query: 786 VRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDF--EKNQLKEDQDKVHMWEQTVK 843
+ ++E EE++++RQ K R E E Q R + F E+ QL+ + + E+
Sbjct: 1673 EQLLQEGEEQQLRRQERDRKFR-EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 844 KDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANK 903
+ E E E+L+++E R+ KI++E QL+ + + ++ E + K E E++R++ +
Sbjct: 1732 RQETEQEQLRRQE-RYRKILEE--EQLRPEREEQQLRRQERDRKFREEEQLRQE----RE 1784
Query: 904 EMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSV 963
E +E + EQ R +R + +D K + + QE+ Q D
Sbjct: 1785 EQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQ 1844
Query: 964 SGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAP 1023
++ + + E + E + + E ++++E QQK ++ + I +
Sbjct: 1845 YRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904
Query: 1024 NMKAMEKL 1031
K +L
Sbjct: 1905 EGKGHGRL 1912
Score = 105 bits (261), Expect = 3e-22
Identities = 186/935 (19%), Positives = 417/935 (44%), Gaps = 113/935 (12%)
Query: 179 EEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKL 238
+E+ + K+++ +R++ + ++ R ++L++E + + Q K E E+ +
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQ----KRQEQERELAEG 151
Query: 239 NKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKE-IKEKDSELNQKRPQ 297
++ + + ++D++R D +EL +++E + RE+++ E+E ++ ++ P
Sbjct: 152 EEQSEKQERLEQRDRQRRD---EELWRQRQEWQE--REERRAEEEQLQSCKGHETEEFPD 206
Query: 298 YIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDM--DELEKEMLSVEKARQEFEERME 355
E + + LE +K + Q+ ++R+ + +E EKE E ++ EE+++
Sbjct: 207 -----EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261
Query: 356 EESQSQGRDLTLEENQVKKY-------HRLKEEASKRAATLAQELEKFNRDQKADQ--DR 406
EE + R+L EE Q++K R +EE ++ Q+L + +++ +Q +R
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 407 LDLEERKKVETEAKIKQKLREIE---ENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEV 463
+ +ER++ + E + +Q RE E E Q R E+ EE + +E+++ E +L E
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381
Query: 464 EMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLC 523
++ + + ++L + + + ++ R++ R++++ + ++R
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR-------------- 427
Query: 524 QPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKE-QRGEPETFLPLDYLEVKPTD 582
+ +++++ K + + + ++ RD ++ +E +R E E ++K
Sbjct: 428 EQEEERHE---QKHEQERREQRLKREQEERRDWLKREEETERHEQER----RKQQLKRDQ 480
Query: 583 EKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALD 642
E+ R + KL + R + ++ L+ ++ RR QR K +
Sbjct: 481 EEERRERWLKLEEEERREQQERREQQLR----------REQEERR-----EQRLKRQEEE 525
Query: 643 GTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQ-MKAKRKEAELRQV 701
L Q+ L+ + E+ + + +EK RL +E +EQ +K +++E + +
Sbjct: 526 ERLQQR----LRSEQQLRREQEERREQLLKREEEK--RLEQERREQRLKREQEERRDQLL 579
Query: 702 QSQAHGLQMRLKYSQSD-LEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSRER 760
+ + Q RLK Q + LEQ R L+++ + E L P +++++S E+
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ 639
Query: 761 EMKDLKEKMNQVEDEVFEEFCRE-----IGVRNIREFEEEK-----VKRQNEIAKKRLEF 810
E + ++ + ++ + RE + R RE EEE+ + + E A++R++
Sbjct: 640 EERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS 699
Query: 811 ENQKTRLGIQLDFEKNQLK--------EDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKI 862
K + ++ + + Q K E Q + E+ ++ E+E++ ++EE+ H +
Sbjct: 700 RIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ-WQEEERAHRQQ 758
Query: 863 IDETMAQLQDLKNQHLAKKSEVNDKNH-----EMEEIRKKLGGANKEMTHLQKEVTAIET 917
+E Q +D Q A++ + + E R++ A + Q+ + E
Sbjct: 759 QEE--EQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEE 816
Query: 918 KLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREA 977
K EQ+R R + + + + L + QEE ED +R S R+
Sbjct: 817 K-EQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQ---ERRRSQEQRRDQ 872
Query: 978 LIEIDYGDLCEDLKDAQ----AEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLES 1033
L E+ K + A+ +++++ QQ L E++ LQR + E+
Sbjct: 873 KWR---WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQ 929
Query: 1034 VRDKFQETSDEFEAAR-KRAKKAKQAFE-QIKKER 1066
R++ Q +E + R +R K+ +Q E Q +K++
Sbjct: 930 YREEEQLQQEEEQLLREEREKRRRQERERQYRKDK 964
Score = 104 bits (260), Expect = 5e-22
Identities = 141/794 (17%), Positives = 340/794 (42%), Gaps = 117/794 (14%)
Query: 146 KNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEE 205
K +ER + E EL ++ K++ D ++ + +K A + + E
Sbjct: 1190 KRRQERERQYRE---EEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE 1246
Query: 206 ADRYQRLKDEVVR-AQVQLQLFKLYHNEVEIEKLNK------------ELASKNKEIEKD 252
+++++L+D +R Q Q L L + E ++ + E +E +K+
Sbjct: 1247 NEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKE 1306
Query: 253 KKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENT----SHK 308
KR D+ E K+ +E + R +Q+ +++ +E++ L ++ Q ++ +E +
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEE 1366
Query: 309 IKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEF---------EERMEEESQ 359
++ E +K L+ Q+ ++ + E++ L ++ Q+ EE + Q
Sbjct: 1367 LRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQ 1426
Query: 360 SQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLE------ERK 413
+ R EE QV++ R ++ + + KF +++ Q+R + + +RK
Sbjct: 1427 ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRK 1486
Query: 414 KVETEAKIKQKLRE--IEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRID 471
+E E +++++ R+ E + R ++ E +Q L Q++ L EE ++ ++
Sbjct: 1487 FLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQ--- 1543
Query: 472 EINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQ 531
E Q Q D + +E RQ+R+ + + +R +K++
Sbjct: 1544 ----ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER-----------------DRKFR 1582
Query: 532 IAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGA 591
+ KV + + ++ E Q ++ Q G+ + D + + ++ L+E +
Sbjct: 1583 LEEQKVRRQEQERKFMEDE-------QQLRRQEGQQQLRQERDR-KFREDEQLLQEREEQ 1634
Query: 592 KLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGV 651
+L + +K L+ + R H R + + L Q+
Sbjct: 1635 QL------HRQERDRKFLEEE-------PQLRRQEREQQLRHDRDRKFREEEQLLQE--- 1678
Query: 652 ISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMR 711
G L+ +++++R E ++Q++ + +E + Q + Q ++
Sbjct: 1679 --GEEQQLR--------------RQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELE 1722
Query: 712 LKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQ 771
K+ + + + +T L QE+ + E P + + Q R+R+ ++ +E++ Q
Sbjct: 1723 RKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE-EEQLRQ 1781
Query: 772 VEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRL---GIQLDFEKNQL 828
+E ++ + R R EEE+++++ E + R + + K R +QL+ ++ +L
Sbjct: 1782 EREE--QQLRSQESDRKFR--EEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRL 1837
Query: 829 KEDQDKVHMWEQ---TVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVN 885
++++D+ + E+ T +K E ++L +EE++ + + + L+ +H+ ++ +
Sbjct: 1838 RQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRR-----QERERKLREEHIRRQQKEE 1892
Query: 886 DKNHEMEEIRKKLG 899
++ ++ EI+ + G
Sbjct: 1893 QRHRQVGEIKSQEG 1906
Score = 85.5 bits (210), Expect = 3e-16
Identities = 89/440 (20%), Positives = 202/440 (45%), Gaps = 45/440 (10%)
Query: 116 EYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEM 175
++ EE ++L + R F + + K +E L + + L +E R++E
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQER 1545
Query: 176 -VKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVE 234
+ +D + ++ + ER+E + ++E DR RL+++ VR Q Q + F ++
Sbjct: 1546 GQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR 1605
Query: 235 IEKLNKELAS-KNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQ 293
++ ++L ++++ +D++ + + E++ +++ K + E+ Q+ ++ E++ +L
Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ--EREQQLRH 1663
Query: 294 KRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMD----ELEKEMLSVEKA--R 347
R + + +E E ++ L+ ++ K R+ + E E++ L E+ R
Sbjct: 1664 DRDRKFREEEQLLQ-----EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRR 1718
Query: 348 QEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQK---ADQ 404
QE E + EE Q + + + ++Y ++ EE R Q+L + RD+K +Q
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ 1778
Query: 405 DRLDLEER--------KKVETEAKIKQKLREI-------------EENQKRIEKLEEYIT 443
R + EE+ +K E +++Q+ E EE Q ++E+ E+ +
Sbjct: 1779 LRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRL- 1837
Query: 444 TSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEI 503
+Q + Q + E + + E ++R E+ +E Q Q + ++ + RQQ++ +
Sbjct: 1838 --RQERDRQYRAEEQFATQ-EKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894
Query: 504 MESIKRL--YPGSVYGRLID 521
+ + G +GRL++
Sbjct: 1895 HRQVGEIKSQEGKGHGRLLE 1914
Score = 82.4 bits (202), Expect = 2e-15
Identities = 77/353 (21%), Positives = 179/353 (50%), Gaps = 28/353 (7%)
Query: 166 QEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEA--KQEKEEADRYQRLKDEVVRAQVQL 223
Q+ ++++E+ + EE ++ ++ R E +Q +E +R +R +E QL
Sbjct: 139 QKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEE-----QL 193
Query: 224 QLFKLYHNEV--EIEKLNK----ELASKNKEIEKDKKR--MDKV--EDELKEKKKELGKM 273
Q K + E + E+L + EL K +E ++ ++R D+V E+E KE +K +
Sbjct: 194 QSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL 253
Query: 274 MREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDM 333
+E++++++E ++ EL ++ Q K + + ++ E ++ ++ ++++
Sbjct: 254 RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ--- 310
Query: 334 DELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYH-RLKEEASKRAATLAQE 392
E+E ++ R+E +ER E++ + + + L E+ + ++ R ++E +R L +E
Sbjct: 311 ---EEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE 367
Query: 393 LEKFNRDQKADQD-RLDLEERKKVETEAKIKQKLREIEENQKRIEKL--EEYITTSKQSL 449
E+ R+Q+ ++ +L E++ + E + + +Q+LR E+ +R ++L E+ + +Q
Sbjct: 368 QEEERREQQLRREQQLRREQQLRREQQLRREQQLRR-EQQLRREQQLRREQQLRREQQLR 426
Query: 450 EEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAE 502
EQ++ E E E ++R+ +E +++ + QE +QQ K +
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479
Score = 77.8 bits (190), Expect = 6e-14
Identities = 92/422 (21%), Positives = 192/422 (45%), Gaps = 37/422 (8%)
Query: 672 DKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNL 731
++ ++++ER ++ + + + +R+E +LR+ Q + Q+R + + EQ R
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE----- 367
Query: 732 QEKSKLESELANFGPRINDIKRIIQSR-----EREMKDLKEKMNQVEDEVFEE--FCREI 784
QE+ + E +L R ++R Q R RE + +E+ + E ++ E RE
Sbjct: 368 QEEERREQQLR----REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 423
Query: 785 GVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKK 844
+R +E E + K + E ++RL+ E ++ R D+ K + + ++ + +Q +K+
Sbjct: 424 QLRREQEEERHEQKHEQERREQRLKREQEERR-----DWLKREEETERHEQERRKQQLKR 478
Query: 845 DENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEV-NDKNHEMEEIRKKLGGANK 903
D+ E + +R +K+ +E + Q+ + Q L ++ E ++ + +E ++L +
Sbjct: 479 DQEE-----ERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533
Query: 904 EMTHLQKEVTAIETKLEQ--KRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGED 961
L++E E + EQ KR + L Q + Q +K + + +EE Q
Sbjct: 534 SEQQLRREQ---EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRL 590
Query: 962 SVSGSQRISSIYAREALIEIDYGDLCED-LKDAQAEEEIKQEMNTLQQKLNEQQSVLQRI 1020
+R+ RE + ++ + E LK + EEE +Q++ +++ +Q L+R
Sbjct: 591 KREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE 650
Query: 1021 AAPNMKAMEKLESVRDKF-QETSDEFEAARKRAKKAKQAFEQIK---KERFDRFNACFES 1076
+ K E ++ Q E E R+ + A++ EQ + K R ++ ES
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710
Query: 1077 VA 1078
A
Sbjct: 711 EA 712
Score = 50.8 bits (120), Expect = 8e-06
Identities = 81/411 (19%), Positives = 180/411 (43%), Gaps = 21/411 (5%)
Query: 674 LKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQE 733
L E+K + + ++ +R+E + R+ + + L+ + Q + R LA ++
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 734 KSKLES-ELANFGPRINDIKRIIQS-REREMKDLKE------KMNQVEDEVFEEFCREIG 785
K E E + R ++ R Q +ERE + +E K ++ E+ EE R
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 786 VRNIR-----EFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQ 840
+ +R E ++++ +RQ+ + ++ E E +K ++ + EK Q +E Q + + E+
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE 274
Query: 841 TVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGG 900
+ + E ++L++E Q + + + + Q L+ + ++ E ++ E +E R++
Sbjct: 275 EEQLRKLERQELRRERQEEEQ-QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEE 333
Query: 901 ANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGE 960
++ ++E E +L +++ + Q + Q+ + + + + E + E
Sbjct: 334 RREQQLRREQEERR-EQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRRE 392
Query: 961 DSVSGSQRI---SSIYAREALIEIDYGDLCEDLKDAQAEE--EIKQEMNTLQQKLNEQQS 1015
+ Q++ + + L + L+ Q EE E K E +Q+L +Q
Sbjct: 393 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE 452
Query: 1016 VLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKER 1066
+R + E+ E R K Q D+ E R+R K ++ + ++ER
Sbjct: 453 E-RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER 502
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 129 bits (323), Expect = 2e-29
Identities = 215/1114 (19%), Positives = 485/1114 (43%), Gaps = 158/1114 (14%)
Query: 52 KTSNLRVKTLRDLIHGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKV 111
+T N +K ++DL + A A + Y EE + + + + E V
Sbjct: 148 QTENFNIKQMKDLFE-QKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATV 206
Query: 112 VQLHEYSEELEKLGI---LIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEY 168
+Q + +E L++ GI + + + Q ++++ ++ +E L +E + L +Y
Sbjct: 207 IQDLK-TELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKK---LQSQY 262
Query: 169 -------DKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQV 221
+ + E+ K ++ + + + E Q+ Q L + +++ +
Sbjct: 263 ASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKN------QTLTENLLKKEQ 316
Query: 222 QLQLFKLYHNEVEIEKLNKE--LASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQ 279
+ HNE + K N + L K+ + ++ + R+ E L EL + Q+
Sbjct: 317 DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK 376
Query: 280 IEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKE 339
+++E+ E +++ Q++KA+ K+L+ + + ++H + + ++++L +
Sbjct: 377 LKEELSEVETKY-----QHLKAE------FKQLQQQR---EEKEQHGLQLQSEINQLHSK 422
Query: 340 MLSVEKARQEFEERMEEESQSQGRDLTLEENQVK----KYHRLKEEASKRAATLAQELEK 395
+L E+ E R++E+ Q L +E QV K RL+E+ ++ + +
Sbjct: 423 LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
Query: 396 FNRDQKADQDRLDLEER---KKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQ 452
++ ++ Q++ L++ K E + ++Q LR+I + ++I+ LE + SK+++
Sbjct: 483 LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLL 542
Query: 453 KKLEGELTEEVEMAK------RRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMES 506
+K +L +++ + ++ E N L + + QL + ++ Q S +Q + + +
Sbjct: 543 EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTE-KLKNQSESHKQAQENLHDQ 601
Query: 507 I--KRLYPGSVYGRLIDL--------CQPTQKKYQIAVTKVLGKNMDAIIVDSE------ 550
+ ++ + + R++ L Q + K +++ + K +++ +E
Sbjct: 602 VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ 661
Query: 551 --------KTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEK---------LRELKGAKL 593
T ++ +Q +++ + T LD + K D++ L+E K L
Sbjct: 662 RADLQNHLDTAQNALQDKQQELNKITT--QLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 719
Query: 594 VIDVIRYE-PPHIKK----ALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQK 648
++ E IKK +L+ +++ R++ + L L +
Sbjct: 720 SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQL--NTDLELRATELSKQLEME 777
Query: 649 SGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGL 708
++S DL+ K+ +A++ +K+K + EE +Q+ + E ++ + Q L
Sbjct: 778 KEIVSSTRLDLQKKS-----EALESIKQKLTKQEEE--KQILKQDFETLSQETKIQHEEL 830
Query: 709 QMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEK 768
R++ + ++L++ K EK L +EL+ +++ + +++ + E EK
Sbjct: 831 NNRIQTTVTELQKVK--------MEKEALMTELSTVKDKLSKVSDSLKNSKSEF----EK 878
Query: 769 MNQVEDEV---FEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKT-RLGIQLDFE 824
NQ E+ C+E+ ++ E +K Q E+ KK LE E + + +L ++L+
Sbjct: 879 ENQKGKAAILDLEKTCKEL-KHQLQVQMENTLKEQKEL-KKSLEKEKEASHQLKLELNSM 936
Query: 825 KNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEV 884
+ QL + Q+ + E+ ++ + I +LK+ ++ K I+ A +LK L K
Sbjct: 937 QEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE---ALQGELKIAVLQKTELE 993
Query: 885 NDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSD---RHNLLQACKMQDIKLP 941
N ++ + ++L ++++ LQ + +Q +SD R + L A + QD+K
Sbjct: 994 NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATR-QDLKSV 1052
Query: 942 LSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYG-------DLCEDLKDAQ 994
K + ++QE+ S + ++ I + +A +E D + C+ L+D Q
Sbjct: 1053 EEKLS---LAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQ 1109
Query: 995 AEEEIKQ-EMNTLQQKLNEQQSVLQRIAAPNMKAME-----KLESVRD------------ 1036
E+ +K+ E+ + KL E + + R K E KLES+++
Sbjct: 1110 KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLI 1169
Query: 1037 ----KFQETSDEFEAARKRAKKAKQAF-EQIKKE 1065
+ Q +D +AA ++ K+ +Q +Q+KKE
Sbjct: 1170 QQKLELQGKADSLKAAVEQEKRNQQILKDQVKKE 1203
Score = 119 bits (298), Expect = 2e-26
Identities = 213/1049 (20%), Positives = 450/1049 (42%), Gaps = 132/1049 (12%)
Query: 157 EISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQ-RLKDE 215
E+S GE Q K K+E+ + E Q ++ AE K+ +Q++EE +++ +L+ E
Sbjct: 366 ELSEKGEATQ---KLKEELSEVETKYQ-------HLKAEFKQLQQQREEKEQHGLQLQSE 415
Query: 216 VVRAQVQL-----QLFKLYHNEVEIEKLNKE-LASKNKEIEKDKKRMDKVEDELKEKKKE 269
+ + +L QL + + E +L+ E L K +++ + ++ ++E++LKEK
Sbjct: 416 INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475
Query: 270 LGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKR 329
++ + + +++ +E+ + + +A+ + ++++ + +QN + +K
Sbjct: 476 STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535
Query: 330 KGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLK--EEASKRA- 386
K ++ LEKE + Q E +Q Q ++ TL+E + +LK E+ K+A
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595
Query: 387 ATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSK 446
L ++++ +A QDR+ E E +++ + ++ + +I+ E + +++
Sbjct: 596 ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAE 655
Query: 447 QSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARI---DRQES--------- 494
+ Q+ +L ++ A+ + + +ELN++ QL D+QE
Sbjct: 656 AAKTAQR---ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 712
Query: 495 -------SRQQRKAEIMESIKRLYPGSVYGR------LIDLCQPTQKKYQIAVTKV-LGK 540
S +Q+ E+ IK+L S+ + L DL Q Q + + L K
Sbjct: 713 EYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK 772
Query: 541 --NMDAIIVDSEKTG----RDCIQYIKE---QRGEPETFLPLDY----LEVKPTDEKLR- 586
M+ IV S + + ++ IK+ ++ E + L D+ E K E+L
Sbjct: 773 QLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832
Query: 587 -------ELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTV 639
EL+ K+ + + E +K L + V D++++++ +Q+ K
Sbjct: 833 RIQTTVTELQKVKMEKEALMTELSTVKDKL------SKVSDSLKNSKSEFEKENQKGKAA 886
Query: 640 ALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELR 699
LD + +LK + + E + + KE K+ L KE+ + + + EL
Sbjct: 887 ILD---------LEKTCKELKHQLQVQMENTLKEQKELKKSLE---KEKEASHQLKLELN 934
Query: 700 QVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQE-KSKLESELANFGPRINDIK-RIIQS 757
+Q Q Q LK ++ + +Q L N+ E K E + ++K ++Q
Sbjct: 935 SMQEQLIQAQNTLKQNEKEEQQ-----LQGNINELKQSSEQKKKQIEALQGELKIAVLQK 989
Query: 758 REREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVK--------RQNEIAKKRLE 809
E E K L++++ Q E+ E + ++N E +E K R++E+ R +
Sbjct: 990 TELENK-LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD 1048
Query: 810 FENQKTRLGI-QLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMA 868
++ + +L + Q D N+ + + E K E + KKE+Q + E
Sbjct: 1049 LKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQ-----LQERCK 1103
Query: 869 QLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHN 928
LQD++ + K+ E+ ++ ++ EI + KE+T L +E+ + + + ++ ++ +
Sbjct: 1104 ALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKD 1163
Query: 929 LLQACKMQDIKLPLSKGTMDDISQEEGSSQG--EDSVSGSQR--ISSIYAREALIEIDYG 984
Q Q ++L ++ ++E +Q +D V + +EA + +
Sbjct: 1164 AKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKL---HS 1220
Query: 985 DLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDE 1044
++ E + EE + ++ LNE +++ + + + +LE D +
Sbjct: 1221 EIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAV 1280
Query: 1045 FEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPENP- 1103
EA + + ++A ER + E + T + E+ + L ++A LG EN
Sbjct: 1281 LEATVQNNQDERRAL----LERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQS 1336
Query: 1104 -EEPYLDGIN---------YNCVAPGKRF 1122
+ + +N NC+A GK F
Sbjct: 1337 LQIKHTQALNRKWAEDNEVQNCMACGKGF 1365
Score = 94.4 bits (233), Expect = 6e-19
Identities = 181/916 (19%), Positives = 358/916 (39%), Gaps = 151/916 (16%)
Query: 296 PQYIKAKENTSHKIKKLEAA----KKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFE 351
PQ +K+ + K EA S + + ++ D+ L +E+ ++ + +E +
Sbjct: 44 PQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEK 103
Query: 352 ERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEE 411
EE + + L++ + K L ++S +L Q+LE+ + + DL E
Sbjct: 104 WYSEELKKELEKYQGLQQQEAKP-DGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFE 162
Query: 412 RKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRID 471
+K + +I + +E + E E+ +T + L ++ + +L E+ + + I+
Sbjct: 163 QKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL-LQRPGIE 221
Query: 472 EI---NKELNQVMEQLGDARIDRQESSRQQR-------------KAEIMESIKRLYPG-- 513
++ KEL QV + + ++R+ S + + +A I + L G
Sbjct: 222 DVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQ 281
Query: 514 --SVY----GRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSE----------------K 551
+VY +L +K Q +L K D ++ + +
Sbjct: 282 EVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQ 341
Query: 552 TGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQY 611
DC Q ++ + ET L ++E+ E ++LK ++ +Y+ H+K +
Sbjct: 342 KDLDC-QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVET-KYQ--HLKAEFKQ 397
Query: 612 ACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAV 671
+ + G + + L L + + LK + + EK +
Sbjct: 398 L--------QQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLM 449
Query: 672 DK------LKEKKERLTEELKE--------QMKAKRKEAELRQVQSQAHGLQMRLKYSQS 717
DK L+ K RL E+LKE Q + + + + ++ Q+ +L+ +Q+
Sbjct: 450 DKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN 509
Query: 718 DLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVF 777
DLEQ L++ + ++ N + K I E+E +DL K+ E E
Sbjct: 510 DLEQV--------LRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET- 560
Query: 778 EEFCREIGVRNIREFEE-----EKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQ 832
++ +N E+ EK+K Q+E K+ E L Q+ +K L+ Q
Sbjct: 561 -AVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE------NLHDQVQEQKAHLRAAQ 613
Query: 833 DKVHMWEQTVKKDENEI-EKLKKEEQRHMKIIDET----------MAQLQDLKNQHLAKK 881
D+V E +V + +++ E +K Q ++I +T AQ DL+N +
Sbjct: 614 DRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQ 673
Query: 882 SEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIET----------KLEQKRSDRHNLLQ 931
+ + DK E+ +I +L ++ Q+ + +E+ LEQK + ++
Sbjct: 674 NALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIK 733
Query: 932 ACKMQDIKLPLSK-GTMDDISQEEGSS--------------QGEDSVSGSQRISSIYARE 976
+ +++ SK + D+ Q+ + + E + S R+ E
Sbjct: 734 KLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSE 793
Query: 977 ALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQ-----------SVLQRIAAPNM 1025
AL I + K + ++ +KQ+ TL Q+ Q + LQ++
Sbjct: 794 ALESIKQ----KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKE 849
Query: 1026 KAMEKLESVRDKFQETSD-------EFEAARKRAKKAKQAFEQIKKERFDRFNACFESVA 1078
M +L +V+DK + SD EFE ++ K A E+ KE + E+
Sbjct: 850 ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909
Query: 1079 TNIDEIYKALSRNSSA 1094
E+ K+L + A
Sbjct: 910 KEQKELKKSLEKEKEA 925
Score = 45.4 bits (106), Expect = 3e-04
Identities = 46/267 (17%), Positives = 115/267 (43%), Gaps = 33/267 (12%)
Query: 139 AVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKE 198
A++ I + + L E S+ E+ + +++KE+ K E + H+ ++I
Sbjct: 1104 ALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE--ELKSHKLESI------ 1155
Query: 199 AKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDK 258
+E + K +++ +++LQ + S +E++K+
Sbjct: 1156 -----KEITNLKDAKQLLIQQKLELQ---------------GKADSLKAAVEQEKRNQQI 1195
Query: 259 VEDELKEKKKELGK-MMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKK 317
++D++K++++EL K + ++ ++ EIKEK+ + + K + + L KK
Sbjct: 1196 LKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKK 1255
Query: 318 SLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHR 377
Q++Q+ + + D+L E+ +E Q ++E ++ E +++K
Sbjct: 1256 EWQSSQRRVSELEKQTDDLRGEIAVLEATVQ----NNQDERRALLERCLKGEGEIEKLQT 1311
Query: 378 LKEEASKRAATLAQELEKFNRDQKADQ 404
E ++ +++ R+ ++ Q
Sbjct: 1312 KVLELQRKLDNTTAAVQELGRENQSLQ 1338
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 129 bits (323), Expect = 2e-29
Identities = 182/956 (19%), Positives = 417/956 (43%), Gaps = 114/956 (11%)
Query: 147 NPKERTALFEEISRSGELAQEYDKRKKE-------MVKAEEDTQFNYHRKKNIAAERKEA 199
N E L E+SR ++ Q +K+E ++E++ + +H ++ E+K
Sbjct: 1314 NVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSL 1373
Query: 200 KQEKEEADRY----QRLKD------EVVRAQVQLQLFKLYHNEV--EIEKLNKELASKNK 247
+ E EE R Q+ KD E + +++++ +H ++ EIE + K L +
Sbjct: 1374 ECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRS 1433
Query: 248 EIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSH 307
E+ + + + + E EL K++ + + ++ + + +S+ + + + T+
Sbjct: 1434 ELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELE----RRAQETAV 1489
Query: 308 KIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQ-------EFEERMEEESQS 360
+ K + +SLQ K ++ K +E+ KE+ + A+ + +E++ EE Q
Sbjct: 1490 NLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQK 1549
Query: 361 QGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERK------- 413
+D+ + E + ++ +E+ ELEK + Q + + +R+
Sbjct: 1550 LQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEE 1609
Query: 414 -------KVETEAKIKQKLR--EIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVE 464
V+ +A +++ LR E E +K +I K LEE +GEL ++
Sbjct: 1610 LHLLQGSMVQAKADLQEALRLGETEVTEKC-----NHIREVKSLLEELSFQKGELNVQIS 1664
Query: 465 MAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQ 524
K ++ I +E+ + E L ++ ++ S+ + + + + + +L + G + Q
Sbjct: 1665 ERKTQLTLIKQEIEKEEENL---QVVLRQMSKHKTELKNILDMLQLENHELQGLKL---Q 1718
Query: 525 PTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYI-KEQRGEPETFLPLDYLEVKPTDE 583
Q+ ++ T+V V EK + +Q I ++Q+GE E L + + +
Sbjct: 1719 HDQRVSELEKTQVA--------VLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIER 1770
Query: 584 KLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDG 643
E + + ++ + E K+ LQ C D +R A +
Sbjct: 1771 MTAESRALQSCVECLSKE----KEDLQEKC----------DIWEKKLAQTKRVLAAAEEN 1816
Query: 644 TLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKE-QMKAKRKEAELRQVQ 702
+ ++S + L+ R+ ++ +D+L K L ++ Q + + K + +Q
Sbjct: 1817 SKMEQSNL-----EKLELNVRKLQQE-LDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQ 1870
Query: 703 SQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREM 762
+ +Q L ++ DL T T+H + L E+++L+ +++ + R D ++ +++++++
Sbjct: 1871 EELANVQDHLNLAKQDLLHT-TKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQL 1929
Query: 763 KDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLD 822
+ L+ N++E+ + +E+ + + ++E+ ++++ ++ + Q+ +L +L
Sbjct: 1930 QVLQ---NEIEENKLKLVQQEMMFQRL---QKERESEESKLETSKVTLKEQQHQLEKELT 1983
Query: 823 FEKNQLKEDQDKVHMWEQ---TVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLA 879
+K++L + KV E+ T++++E E L+K + + + E QL + + LA
Sbjct: 1984 DQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLA 2043
Query: 880 KKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIK 939
+ E + + +R + K+ +K+V +++ L+ +RS L K ++
Sbjct: 2044 LQKEADSMRADFSLLRNQFLTERKKA---EKQVASLKEALKIQRSQLEKNLLEQKQENSC 2100
Query: 940 LPLSKGTMDDISQEE-----------GSSQGEDSVSGSQRISSIYAREALIEIDYGDLCE 988
+ T++ ++Q+ Q E + Q + +EI D
Sbjct: 2101 IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEIS--DAMR 2158
Query: 989 DLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDE 1044
LK ++ ++EI+ + L Q L E + L+ I N +LES+++ T +E
Sbjct: 2159 TLK-SEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNE 2213
Score = 98.6 bits (244), Expect = 3e-20
Identities = 148/775 (19%), Positives = 339/775 (43%), Gaps = 72/775 (9%)
Query: 155 FEEISRSGE-LAQEYDKRKK--EMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQR 211
F+ +S+ E L +E K +K EM + ED ++ + + K A+ EK
Sbjct: 1533 FQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEK-------- 1584
Query: 212 LKDEVVRAQVQLQLF--KLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVE-----DELK 264
LK +V Q ++ + +L H + E+ L + +++ + R+ + E + ++
Sbjct: 1585 LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQ-EALRLGETEVTEKCNHIR 1643
Query: 265 EKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQK 324
E K L ++ ++ ++ +I E+ ++L + + K +EN ++++ K L+N
Sbjct: 1644 EVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILD 1703
Query: 325 HYKKRKGDMD-----------ELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVK 373
+ ++ ELEK ++V + + E E +++ SQ Q ++ ++ ++
Sbjct: 1704 MLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN-LQQISQQQKGEIEWQKQLLE 1762
Query: 374 KYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQK 433
+ R E + + L +E +++++ Q++ D+ E+K +T+ + + Q
Sbjct: 1763 RDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQS 1822
Query: 434 RIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDAR----I 489
+EKLE + +Q L++ + + L ++ ++++ E + +N + E+L + + +
Sbjct: 1823 NLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNL 1882
Query: 490 DRQESSRQQRKAEIM--ESIKRLYPGSVYGRLIDLCQPTQ--KKYQIAVTKVLGKNMDAI 545
+Q+ + +++ E + S + + CQ + K+ Q+ V + +
Sbjct: 1883 AKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLK 1942
Query: 546 IVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKL-RELKGAKLVIDVIRYEPPH 604
+V E Q ++++R E+ L + +K +L +EL K +D + +
Sbjct: 1943 LVQQEM----MFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLA 1998
Query: 605 IKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKAR 664
++ ++ C+++E + + + L +KSG +L A +
Sbjct: 1999 AEERVRTLQEEERWCESLEKTL-----SQTKRQLSEREQQLVEKSG-------ELLALQK 2046
Query: 665 RWDEKAVDKLKEKKERLTEELK-EQMKAKRKEA-ELRQVQSQAHGLQMRLKYSQSDLEQT 722
D D + + LTE K E+ A KEA ++++ Q + + L+ + + S E
Sbjct: 2047 EADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMA 2106
Query: 723 KTRHLALNLQEKS-KLESELANFGPRINDIKRIIQSR---EREMKDLKEKMNQVEDEVFE 778
+A + E++ +L EL ++K+ + ++ ER ++ + M ++ EV +
Sbjct: 2107 TIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKD 2166
Query: 779 EFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMW 838
E ++N+ +F E I ++ E + L L F N+ ++K++ +
Sbjct: 2167 EI--RTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNE-GPFEEKLN-F 2222
Query: 839 EQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEE 893
Q DE+ + +E+ RH + D AQL+ ++K++EV K E
Sbjct: 2223 SQVHIMDEHWRGEALREKLRHRE--DRLKAQLRHC----MSKQAEVLIKGKRQTE 2271
Score = 97.4 bits (241), Expect = 7e-20
Identities = 166/857 (19%), Positives = 371/857 (43%), Gaps = 121/857 (14%)
Query: 231 NEVE-IEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDS 289
NEV +E + + L SK +E + + E E++E + +++E++ +E E++E
Sbjct: 1323 NEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHR 1382
Query: 290 ELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQE 349
+ +++ Q N + +LE ++ + KH++ +++ +EK +L +E
Sbjct: 1383 TVQKRQQQKDFIDGNVESLMTELE-----IEKSLKHHEDIVDEIECIEKTLLKRRSELRE 1437
Query: 350 FEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQ-----KADQ 404
+ + E +N V+K+ K + + A+ELE+ ++ KADQ
Sbjct: 1438 ADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESD-AEELERRAQETAVNLVKADQ 1496
Query: 405 DRLDLEERKKVETEAKIKQK--LREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEE 462
L+ K + KIKQ+ L+EI + + + ++ K+ L E+ + +L ++
Sbjct: 1497 QLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQ---KLQKD 1553
Query: 463 VEMAKRRID---EINKELNQVMEQLGDARIDR---QESSRQQRKAEIMESI--KRLYPGS 514
+EMA+R D ++ KE ++V+ Q A +++ Q +S+QQ A + + K+
Sbjct: 1554 IEMAERNEDHHLQVLKE-SEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHL 1612
Query: 515 VYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLD 574
+ G ++ Q+ ++ T+V K + + + ++ + Q+GE
Sbjct: 1613 LQGSMVQAKADLQEALRLGETEVTEK------CNHIREVKSLLEELSFQKGE-------- 1658
Query: 575 YLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQ 634
L V+ ++ K + L+ I E +++ L+ + N+ D ++ +
Sbjct: 1659 -LNVQISERKTQ----LTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQL-----E 1708
Query: 635 RHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRK 694
H+ L G Q +S ++ V L+EK E E L++ + ++
Sbjct: 1709 NHE---LQGLKLQHDQRVS-----------ELEKTQVAVLEEKLE--LENLQQISQQQKG 1752
Query: 695 EAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRI 754
E E ++ + ++ ++S Q+ L+ +EK L+ + + ++ KR+
Sbjct: 1753 EIEWQKQLLERDKREIERMTAESRALQSCVECLS---KEKEDLQEKCDIWEKKLAQTKRV 1809
Query: 755 IQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQK 814
+ + E K + + ++E N+R+ ++E +++ + +L N
Sbjct: 1810 LAAAEENSKMEQSNLEKLE-------------LNVRKLQQEL----DQLNRDKLSLHNDI 1852
Query: 815 TRLGIQLDFEK---NQLKED----QDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETM 867
+ + QL ++ N L+E+ QD +++ +Q + + L E+ R K I E
Sbjct: 1853 SAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWA 1912
Query: 868 AQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRH 927
+ +D + + K+ ++ +E+EE + KL LQKE + E+KLE + +
Sbjct: 1913 NRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLE---TSKV 1969
Query: 928 NLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLC 987
L + + +L K +D + + ++ +R+ ++ E C
Sbjct: 1970 TLKEQQHQLEKELTDQKSKLDQVLSK--------VLAAEERVRTLQEEER--------WC 2013
Query: 988 EDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEA 1047
E L+ + + K++++ +Q+L E+ L + ++ +S+R F ++F
Sbjct: 2014 ESLE--KTLSQTKRQLSEREQQLVEKSGEL-------LALQKEADSMRADFSLLRNQFLT 2064
Query: 1048 ARKRAKKAKQAFEQIKK 1064
RK+A+K + ++ K
Sbjct: 2065 ERKKAEKQVASLKEALK 2081
Score = 92.4 bits (228), Expect = 2e-18
Identities = 185/883 (20%), Positives = 361/883 (40%), Gaps = 191/883 (21%)
Query: 210 QRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKE 269
+ L+ + V Q + + F+ + E E+E+L ++L K E E+ K + + +E+K + K
Sbjct: 248 ESLEGQPVTTQDRQEAFERFSLE-EVERLERDLEKKMIETEELKSKQTRFLEEIKNQDK- 305
Query: 270 LGKMMREQQQIEKE-IKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKK 328
L K ++E+ ++K+ +E S+LN K N K K +E + QK Y
Sbjct: 306 LNKSLKEEAMLQKQSCEELKSDLNTK---------NELLKQKTIELTRA----CQKQY-- 350
Query: 329 RKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKE-----EAS 383
ELE+E L+ K +FE S+ D +E+ R K E+
Sbjct: 351 ------ELEQE-LAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESY 403
Query: 384 KRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYIT 443
+ A +++K D++ D ++L ++T+ + K+K +I Q R+ +L + I
Sbjct: 404 IIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEK--KISAAQTRLSELHDEIE 461
Query: 444 TSKQSL----EEQKKLEGELTEEVEMAKRRIDEINKELN---QVMEQLGDARIDRQESSR 496
++Q + EE K+LE E + ++++ D + K+L+ Q++ +L +D E
Sbjct: 462 KAEQQILRATEEFKQLE-EAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALD-LELQM 519
Query: 497 QQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDC 556
+++K EI K + + ID K+ + GK I++ +
Sbjct: 520 EKQKQEIAGKQKEIKDLQI---AIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQ------ 570
Query: 557 IQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNA 616
Q ++ + E + + + E+K +E+L E Q A A
Sbjct: 571 YQQLESRLDEILSRIAKETEEIKDLEEQLTE---------------------GQIAANEA 609
Query: 617 LVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKE 676
L +D + G L + G I G A+ + + R KL++
Sbjct: 610 L----KKDLEGVISG-------------LQEYLGTIKGQATQAQNECR--------KLRD 644
Query: 677 KKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSK 736
+KE L + L E +++ +L V A ++ L +S L++ + +L Q +
Sbjct: 645 EKETLLQRLTE---VEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQ-QTQGD 700
Query: 737 LESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEK 796
L + A R+N R+ E LKE++ EK
Sbjct: 701 LSAYEAELEARLN-------LRDAEANQLKEEL-------------------------EK 728
Query: 797 VKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQD----KVHMWEQTVKKDENEIEKL 852
V R ++ + L+ E +K R ++ K Q E+++ ++H + ++ D N +++
Sbjct: 729 VTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQ 788
Query: 853 KKEEQRHMKII-------DETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEM 905
K+ Q H+ + +E A++ +L+ + E+N I K +
Sbjct: 789 LKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMN--------IHSPSDVLGKSL 840
Query: 906 THLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSG 965
LQK+ + I + + +R + ++++ KL QEE + Q E +G
Sbjct: 841 ADLQKQFSEILARSKWERDE-------AQVRERKL-----------QEEMALQQEKLATG 882
Query: 966 SQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNM 1025
+ ++ CE +A+ + +Q +QQ NE + + N+
Sbjct: 883 QE--------------EFRQACERALEARMNFDKRQHEARIQQMENEIHYLQE-----NL 923
Query: 1026 KAMEKLESVRD-KFQETSDEFE--AARKRAKKAKQAFEQIKKE 1065
K+ME+++ + D + QE +E E A+ R + K+ E K +
Sbjct: 924 KSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQ 966
Score = 83.6 bits (205), Expect = 1e-15
Identities = 185/898 (20%), Positives = 371/898 (41%), Gaps = 134/898 (14%)
Query: 229 YHNEVEIEKLNKE-----LASKNKEIEKDK-KRMDKVEDELKEKKKEL----GKMMREQQ 278
Y E I+KL K+ + S N + KD K+ +E+ K K E+ ++ + +
Sbjct: 82 YITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIE 141
Query: 279 QIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEK 338
+++K +K ++ L+ + I+ EN + ++KL A +++ K+ + L
Sbjct: 142 KLDKLLKLRELNLSYNKISKIEGIENMCN-LQKLNLAGNEIEHIPVWLGKKLKSLRVLNL 200
Query: 339 EMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKK---------YH-RLKEEASKRAAT 388
+ + + + + ++ S L L EN V +H R E + T
Sbjct: 201 KGNKISSLQDISKLKPLQDLIS----LILVENPVVTLPHYLQFTIFHLRSLESLEGQPVT 256
Query: 389 LAQELEKFNRDQKADQDRLDLE-ERKKVETEAKIKQKLREIEE--NQKRIEK-LEEYITT 444
E F R + +RL+ + E+K +ETE ++ R +EE NQ ++ K L+E
Sbjct: 257 TQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAML 316
Query: 445 SKQSLEEQKKLEGELTEEVEMAKRRIDEINKELN---QVMEQLGDARIDRQESSRQQRKA 501
KQS EE L+ +L + E+ K++ E+ + ++ ++L +ID + +
Sbjct: 317 QKQSCEE---LKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPS 373
Query: 502 EIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIK 561
E E K G+ +Y+ +NM A +E D Q ++
Sbjct: 374 EYAEIDKAPDESPYIGK---------SRYK--------RNMFA----TESYIIDSAQAVQ 412
Query: 562 EQRGEPETFLPLDYLEVK---PTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALV 618
++ EP+ L D++ ++ P D +L + K K+ R H
Sbjct: 413 IKKMEPDEQLRNDHMNLRGHTPLDTQLED-KEKKISAAQTRLSELH-------------- 457
Query: 619 CDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKK 678
D +E A + + K L+ + K IS DL K + V+KL++
Sbjct: 458 -DEIEKAEQQILRATEEFK--QLEEAIQLKK--ISEAGKDLLYKQLSGRLQLVNKLRQ-- 510
Query: 679 ERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSK-- 736
E L +++ ++++ E+ Q + LQ+ + L+ +H + Q+ K
Sbjct: 511 ----EALDLELQMEKQKQEIAGKQKEIKDLQIAI----DSLDSKDPKHSHMKAQKSGKEQ 562
Query: 737 ----LESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIG--VRNIR 790
+ + R+++I I E+KDL+E++ + + E +++ + ++
Sbjct: 563 QLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQ 622
Query: 791 EF----EEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDE 846
E+ + + + QNE K R E E RL +++ E++QL + V M + ++K+
Sbjct: 623 EYLGTIKGQATQAQNECRKLRDEKETLLQRL-TEVEQERDQL----EIVAMDAENMRKEL 677
Query: 847 NEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMT 906
E+E +E+ + +T DL ++ +N ++ E +++++L +++T
Sbjct: 678 AELESALQEQHEVNASLQQTQG---DLSAYEAELEARLNLRDAEANQLKEEL----EKVT 730
Query: 907 HL-QKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLS-------KGTMDDISQEEGSSQ 958
L Q E +A++ +LE++R N L + + K + K DD + + Q
Sbjct: 731 RLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLK--QQ 788
Query: 959 GEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQ 1018
+D + + R + +L LK E I + L + L + Q
Sbjct: 789 LKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFS 848
Query: 1019 RIAAPN-----------MKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKE 1065
I A + K E++ ++K +EF A +RA +A+ F++ + E
Sbjct: 849 EILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHE 906
Score = 62.4 bits (150), Expect = 3e-09
Identities = 87/474 (18%), Positives = 202/474 (42%), Gaps = 64/474 (13%)
Query: 659 LKAKAR--RWDEKAVDKLKEKKERLTEELKEQMKAKRK-EAELRQVQSQAHGLQMRLKYS 715
LK+K R RW + + +++ E L + + ++ K+ E E+ ++ Q + +
Sbjct: 1335 LKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFI 1394
Query: 716 QSDLEQTKT--------RHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKE 767
++E T +H + E +E L + + R++ E E+ KE
Sbjct: 1395 DGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKE 1454
Query: 768 KMNQVEDEVFEEFCREIGVRNIREFE---EEKVKRQNEIAKKRLEFENQKTRLGIQL-DF 823
K ++ + R++ + E EE +R E A ++ + Q L D
Sbjct: 1455 KTKNAVEKFTD------AKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDL 1508
Query: 824 EKNQLKEDQ--------------------DKVHMWEQTVKKDENEIEKLKKEEQRHMKII 863
E++++K+++ K + ++K + +IE ++ E H++++
Sbjct: 1509 EQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVL 1568
Query: 864 DETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQK- 922
E+ LQ + + KS+V + EM + ++LG +E+ LQ + + L++
Sbjct: 1569 KESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEAL 1628
Query: 923 RSDRHNLLQACK-MQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEI 981
R + + C ++++K + +E +GE +V S+R + + + IE
Sbjct: 1629 RLGETEVTEKCNHIREVK---------SLLEELSFQKGELNVQISERKTQLTLIKQEIEK 1679
Query: 982 DYGDLCEDLKD-AQAEEEIKQEMNTLQQKLNEQQ----------SVLQRIAAPNMKAMEK 1030
+ +L L+ ++ + E+K ++ LQ + +E Q S L++ ++ +
Sbjct: 1680 EEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLE 1739
Query: 1031 LESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEI 1084
LE+++ Q+ E E ++ ++ K+ E++ E +C E ++ +++
Sbjct: 1740 LENLQQISQQQKGEIEWQKQLLERDKREIERMTAES-RALQSCVECLSKEKEDL 1792
Score = 58.5 bits (140), Expect = 4e-08
Identities = 130/684 (19%), Positives = 286/684 (41%), Gaps = 100/684 (14%)
Query: 104 EYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKE--RTALFEEISRS 161
E KI+ +L E +E+EK I R F+ E+I +K E + L++++S
Sbjct: 443 EKKISAAQTRLSELHDEIEKAEQQI-LRATEEFKQLEEAIQLKKISEAGKDLLYKQLS-- 499
Query: 162 GELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEAD-------RYQRLKD 214
G L Q +K ++E + E + +K+ IA ++KE K + D ++ +K
Sbjct: 500 GRL-QLVNKLRQEALDLELQME---KQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKA 555
Query: 215 EVVRAQVQLQLFKLYHNEVE--IEKLNKELASKNKEIEKDKKRMDKVEDELKEK-KKEL- 270
+ + QL + + ++E ++++ +A + +EI+ ++++ + + E KK+L
Sbjct: 556 QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLE 615
Query: 271 --------------GKMMREQQQIEKEIKEKDS------ELNQKRPQY---IKAKENTSH 307
G+ + Q + K EK++ E+ Q+R Q EN
Sbjct: 616 GVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRK 675
Query: 308 KIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTL 367
++ +LE+A + ++ +GD+ E E+ + R +++EE + R L
Sbjct: 676 ELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQL 735
Query: 368 EENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLRE 427
E++ ++ + +A K A AQ F+ +++ + L + + + +KQ+L++
Sbjct: 736 EQSALQAELEKERQALKNALGKAQ----FSEEKEQENSELHAKLKHLQDDNNLLKQQLKD 791
Query: 428 IEENQKRIEK---LEEYITTSKQSLEEQKKL---EGELTEEVEMAKRRIDEINKELNQVM 481
+ + + E + L + KL E + ++ + + ++ K+ +++
Sbjct: 792 FQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEI- 850
Query: 482 EQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKN 541
L ++ +R E+ ++RK + ++++ + Q++++ A + L
Sbjct: 851 --LARSKWERDEAQVRERKLQEEMALQQ-----------EKLATGQEEFRQACERALEAR 897
Query: 542 M-------DAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDE-------KLRE 587
M +A I E I Y++E E L L+++ DE +LRE
Sbjct: 898 MNFDKRQHEARIQQMENE----IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRE 953
Query: 588 LKGAKLVIDVIRYEPPH-IKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLF 646
L+ K + D E + K L+ D + A + + +L GT+
Sbjct: 954 LEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTI----AKDQLKSLHGTVM 1009
Query: 647 QKSGVISGGASDLKAKARRWDEKAVDKLKE------KKERLTEELKEQMKAKRKEAELRQ 700
+ I+ ++ +A R+ KA ++ + E L L+++ + R E E
Sbjct: 1010 K----INQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTG 1065
Query: 701 VQSQAHGLQMRLKYSQSDLEQTKT 724
V + A+ + ++ +E+ +T
Sbjct: 1066 VGTGANSQVLEIEKLNETMERQRT 1089
Score = 56.2 bits (134), Expect = 2e-07
Identities = 87/409 (21%), Positives = 178/409 (43%), Gaps = 69/409 (16%)
Query: 104 EYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGE 163
E ++N + + ++ EELEK+ L + Q A+++ + KER AL + ++ +
Sbjct: 709 EARLNLRDAEANQLKEELEKVTRLTQLE-----QSALQA---ELEKERQALKNALGKA-Q 759
Query: 164 LAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEE--------ADRYQRLKDE 215
++E ++ E+ + + K++ + KQ+ ++ D R ++
Sbjct: 760 FSEEKEQENSEL----------HAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEV 809
Query: 216 VVRAQVQLQLFKLYHNEVEIEK----LNKELASKNKEIEKDKKRMDKVEDELKEKKKELG 271
R + KL E+ I L K LA K+ + R DE + ++++L
Sbjct: 810 AARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQ 869
Query: 272 KMMREQQQI----EKEIKEK-----DSELNQKRPQY---IKAKENTSH----KIKKLEAA 315
+ M QQ+ ++E ++ ++ +N + Q+ I+ EN H +K +E
Sbjct: 870 EEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEI 929
Query: 316 KK----SLQNAQKHYKKRKGDMDELEK-----------EMLSVEKARQEFEERMEEESQS 360
+ LQ A + ++ + ELEK ++ ++K ++ ++ + +
Sbjct: 930 QGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKL 989
Query: 361 QGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAK 420
+LT+ ++Q+K H + ++ A QE E+F+R KA Q DL + E E +
Sbjct: 990 ATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSR--KAAQAARDL---TRAEAEIE 1044
Query: 421 IKQKLREIEENQKRIEKLEEYITT--SKQSLEEQKKLEGELTEEVEMAK 467
+ Q L + Q R+E + + T + Q LE +K E + E+A+
Sbjct: 1045 LLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIAR 1093
Score = 53.9 bits (128), Expect = 9e-07
Identities = 91/433 (21%), Positives = 172/433 (39%), Gaps = 52/433 (12%)
Query: 672 DKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNL 731
++LK K+ R EE+K Q K + E +Q Q+ ++++L + KT L
Sbjct: 287 EELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRAC 346
Query: 732 QEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEE--FCREIGVRNI 789
Q++ +LE ELA + I ++ + + +++ E + RN+
Sbjct: 347 QKQYELEQELAFYK---------IDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNM 397
Query: 790 REFEEEKVKRQNEIAKKRLEFENQ----------KTRLGIQLDFEKNQLKEDQDKVHMWE 839
E + + K++E + Q T L QL+ ++ ++ Q ++
Sbjct: 398 FATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELH 457
Query: 840 QTVKKDENEI----EKLKK-EEQRHMKIIDETMAQL---QDLKNQHLAKK--SEVNDKNH 889
++K E +I E+ K+ EE +K I E L Q L K E D
Sbjct: 458 DEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLEL 517
Query: 890 EMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDD 949
+ME+ ++++ G KE+ LQ + ++++K +H+ ++A K K D
Sbjct: 518 QMEKQKQEIAGKQKEIKDLQIAIDSLDSK-----DPKHSHMKAQKS-------GKEQQLD 565
Query: 950 ISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQ--AEEEIKQEMNTLQ 1007
I ++ R+ I +R A + DL E L + Q A E +K+++ +
Sbjct: 566 IMNKQYQQL-------ESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVI 618
Query: 1008 QKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERF 1067
L E ++ A KL ++ + E E R + + E ++KE
Sbjct: 619 SGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELA 678
Query: 1068 DRFNACFESVATN 1080
+ +A E N
Sbjct: 679 ELESALQEQHEVN 691
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 127 bits (320), Expect = 5e-29
Identities = 196/1035 (18%), Positives = 444/1035 (42%), Gaps = 180/1035 (17%)
Query: 108 NNKVVQLHEYSEEL----EKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGE 163
N+ +Q+ +E L E+ LIK++ ++ + V+ + + +E E +++
Sbjct: 889 NDLQLQVQSETENLMDAEERCEGLIKSK--ILLEAKVKELTERLEEEEEMNSELVAKKRN 946
Query: 164 LAQEYDKRKKE-------MVKAEEDTQFNYHRKKNIAAER--------KEAKQEKEEADR 208
L + K++ + K E++ ++ KN++ E K K++K +
Sbjct: 947 LEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEA 1006
Query: 209 YQRLKDEVVRAQVQLQ-LFKLYHN-EVEIEKLNKELASKNK---EIEKDKKRMDKVEDEL 263
+Q+ D++ + ++ L K+ E + + L L + K ++E+ K+ K+E +L
Sbjct: 1007 HQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKR---KLEGDL 1063
Query: 264 KEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQ 323
K ++ + + ++QQIE+++K+K+ EL+Q + + + ++ KK++ + ++ +
Sbjct: 1064 KMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELE 1123
Query: 324 KHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLK---E 380
+ + ++EK+ + + +E ER+EE S + + + + + ++ +++ E
Sbjct: 1124 EEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLE 1183
Query: 381 EASKRAATLAQELEKFNRDQKADQ----DRLDLEERKKVETEAKIKQKLREIEENQKRIE 436
EA+ + A L K D A+ D L ++K + ++++K ++ ++ N + +
Sbjct: 1184 EATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALS 1243
Query: 437 KLEEYITTSKQSLEEQ-------KKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARI 489
K + I + +++E+Q + + +L ++ M K R+ N EL+ +E+ +
Sbjct: 1244 KSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEE--KESL 1301
Query: 490 DRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDS 549
Q + +Q + +E +KR + + T+ K +A+
Sbjct: 1302 ISQLTKSKQALTQQLEELKR-----------QMEEETKAK-------------NAMAHAL 1337
Query: 550 EKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKAL 609
+ + DC ++EQ E + E K ++ +++ +YE I++
Sbjct: 1338 QSSRHDC-DLLREQYEEEQ--------EAKAELQRALSKANSEVAQWRTKYETDAIQRTE 1388
Query: 610 QYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEK 669
+ + +++A + K +L+ T + G + DL+
Sbjct: 1389 ELEEAKKKLAQRLQEAEENTETANS--KCASLEKTKQRLQGEVEDLMRDLERSHTAC--A 1444
Query: 670 AVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHG---LQMRLKYSQSDLEQTKTRH 726
+DK + +++ E K+++ + E E Q +S++ +MR Y + + R
Sbjct: 1445 TLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRR 1504
Query: 727 LALNLQEK-SKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIG 785
NLQE+ S L ++A G + + ++ + E+E DL+ + +VE +
Sbjct: 1505 ENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL--------- 1555
Query: 786 VRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKD 845
E EE K+ +++ E +Q+K + D+ + ++KD
Sbjct: 1556 -----EHEESKI---------------------LRVQLELSQVKSELDR-----KVIEKD 1584
Query: 846 ENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEM 905
E EIE+LK+ QR + + + +N L K ++ +EME +LG +N++M
Sbjct: 1585 E-EIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEME---IQLGHSNRQM 1640
Query: 906 THLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSG 965
QK + ++ +L+ + + L++ +D+K L
Sbjct: 1641 AETQKHLRTVQGQLKDSQLHLDDALRS--NEDLKEQL----------------------- 1675
Query: 966 SQRISSIYAREALIEIDYGDLCEDLKDAQ-AEEEIKQEMNTLQQKLNEQQSVLQRIAAPN 1024
A++E G L E+L++ + A E+ ++ +Q+L + +Q + + N
Sbjct: 1676 -----------AIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQN 1724
Query: 1025 ---MKAMEKLES--------VRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNAC 1073
+ +KLE+ V + QE+ + E A+K A E++KKE+ +A
Sbjct: 1725 TSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQ--DTSAH 1782
Query: 1074 FESVATNIDEIYKAL 1088
E + N+++ K L
Sbjct: 1783 LERMKKNLEQTVKDL 1797
Score = 107 bits (268), Expect = 5e-23
Identities = 155/827 (18%), Positives = 357/827 (43%), Gaps = 101/827 (12%)
Query: 240 KELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSEL---NQKRP 296
KE+A+ ++ E+ K+ + + E KE ++++ +++E+ ++ +++ + L ++
Sbjct: 851 KEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCE 910
Query: 297 QYIKAKENTSHKIKKL--EAAKKSLQNAQKHYKKR---------KGDMDELEKEMLSVEK 345
IK+K K+K+L ++ N++ KKR K D+D+LE + VEK
Sbjct: 911 GLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEK 970
Query: 346 ARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQ- 404
+ E +++ S+ LEEN + K +++K+ Q
Sbjct: 971 EKHATENKVKNLSEEM---TALEEN----------------------ISKLTKEKKSLQE 1005
Query: 405 ------DRLDLEERK---KVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKL 455
D L +EE K ++ AK++Q+ ++E + ++ +KL + +K+ LE K+
Sbjct: 1006 AHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKM 1065
Query: 456 EGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSV 515
E ++E K++I+E K+ + QL A+ID ++ Q + +I E R+
Sbjct: 1066 SQESIMDLENDKQQIEEKLKKKEFELSQL-QAKIDDEQVHSLQFQKKIKELQARI----- 1119
Query: 516 YGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDY 575
+ + +I L ++ D + + + ++E G + ++
Sbjct: 1120 ----------EELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNK 1169
Query: 576 LEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQR 635
+ R+L+ A L ++E + A A + + +++ +R+ +
Sbjct: 1170 KREAEFQKMRRDLEEATL-----QHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKE 1224
Query: 636 HKTVALD-GTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRK 694
+ ++ + +S S+++ R +++ ++K K E+ T+ + + K +
Sbjct: 1225 KSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQ-FSEIKAKDEQQTQLIHDLNMQKAR 1283
Query: 695 EAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRI 754
+Q+Q L R++ +S + Q AL Q+ +L+ ++ N +
Sbjct: 1284 ------LQTQNGELSHRVEEKESLISQLTKSKQALT-QQLEELKRQMEEETKAKNAMAHA 1336
Query: 755 IQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQK 814
+QS + L+E+ + E E E R + N E + + K + + ++ E E K
Sbjct: 1337 LQSSRHDCDLLREQYEE-EQEAKAELQRALSKAN-SEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 815 TRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLK 874
+L +L + + K E+T ++ + E+E L ++ +R T D K
Sbjct: 1395 KKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLER-----SHTACATLDKK 1449
Query: 875 NQHLAK-----KSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNL 929
++ K K ++++ E+E +K+ + E+ ++ + +LE R + NL
Sbjct: 1450 QRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNL 1509
Query: 930 LQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCED 989
+ ++ D+ +++ T ++ + E + + + ++ AL E++ E+
Sbjct: 1510 QE--EISDLTEQIAE-TGKNLQEAEKTKKLVEQEKSDLQV-------ALEEVEGSLEHEE 1559
Query: 990 LKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRD 1036
K + + E+ Q + L +K+ E+ ++++ + +A E L+SV D
Sbjct: 1560 SKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLD 1606
Score = 92.4 bits (228), Expect = 2e-18
Identities = 166/887 (18%), Positives = 366/887 (41%), Gaps = 123/887 (13%)
Query: 104 EYKINNKVVQLHEYSEEL--EKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRS 161
E K+ K +L + ++ E++ L + Q +E + + E T + +
Sbjct: 1081 EEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQR 1140
Query: 162 GELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQV 221
+LA+E ++ + + +A T K AE ++ +++ EEA +R +
Sbjct: 1141 SDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQ 1200
Query: 222 QLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIE 281
+ +L ++++ ++L + E++ + M + L + K + + R +
Sbjct: 1201 ADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQF 1260
Query: 282 KEIKEKDSE-------LNQKRPQYIKAKENTSHKIKKLEAA----KKSLQNAQKHYKKRK 330
EIK KD + LN ++ + SH++++ E+ KS Q + ++ K
Sbjct: 1261 SEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELK 1320
Query: 331 GDMDELEKEMLSVEKA-----------RQEFEERMEEESQSQG----------------- 362
M+E K ++ A R+++EE E +++ Q
Sbjct: 1321 RQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYE 1380
Query: 363 -----RDLTLEENQVKKYHRLKEE------ASKRAATLAQ-------ELEKFNRDQKADQ 404
R LEE + K RL+E A+ + A+L + E+E RD +
Sbjct: 1381 TDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSH 1440
Query: 405 DR---LDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTE 461
LD ++R + A+ KQKL +E+Q +E ++ + L + + E+ +
Sbjct: 1441 TACATLDKKQRNFDKVLAEWKQKL---DESQAELEAAQKESRSLSTELFKMRNAYEEVVD 1497
Query: 462 EVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLID 521
++E +R + +E++ + EQ+ + + QE+ + ++ E +S ++ V G L +
Sbjct: 1498 QLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL-E 1556
Query: 522 LCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPT 581
+ + Q+ +++V + +D +++ ++ + Q + + E + E++
Sbjct: 1557 HEESKILRVQLELSQVKSE-LDRKVIEKDE---EIEQLKRNSQRAAEALQSVLDAEIRSR 1612
Query: 582 DEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVAL 641
++ LR K K+ D+ E +Q N + + + R + G + + L
Sbjct: 1613 NDALRLKK--KMEGDLNEME-------IQLGHSNRQMAETQKHLRTVQ--GQLKDSQLHL 1661
Query: 642 DGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQV 701
D L DLK ++ A+ ++ + L EEL+E A + R++
Sbjct: 1662 DDALRSN--------EDLK------EQLAI--VERRNGLLLEELEEMKVALEQTERTRRL 1705
Query: 702 QSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSRERE 761
Q L + ++ +++ +L + K KLE+++A + + + ++ E +
Sbjct: 1706 SEQ------ELLDASDRVQLLHSQNTSL-INTKKKLEADIAQCQAEVENSIQESRNAEEK 1758
Query: 762 MKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVK----RQNEI-------AKKRLE- 809
K + +E+ +E + +++ E+ VK R +E KK+++
Sbjct: 1759 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1818
Query: 810 FENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQ 869
EN+ L +LD E+ + E H +E+ VK+ + E+ K R ++D+ A+
Sbjct: 1819 LENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAK 1878
Query: 870 LQDLKNQHLAKKSEVNDK-------NHEMEEIRKKLGGANKEMTHLQ 909
++ K Q + + N + HE+EE ++ A ++ L+
Sbjct: 1879 VKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLR 1925
Score = 77.8 bits (190), Expect = 6e-14
Identities = 83/358 (23%), Positives = 170/358 (47%), Gaps = 41/358 (11%)
Query: 716 QSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDE 775
+ D E+TK LA + + +LE ++ + ND++ +QS + D +E+ E
Sbjct: 857 KEDFERTK-EELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERC---EGL 912
Query: 776 VFEEFCREIGVRNIRE-FEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDK 834
+ + E V+ + E EEE+ +AKKR L+ + + LK D D
Sbjct: 913 IKSKILLEAKVKELTERLEEEEEMNSELVAKKR------------NLEDKCSSLKRDIDD 960
Query: 835 VHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQL-QDLKNQHLAKKSEVNDKNHEMEE 893
+ + V+K+++ E K M ++E +++L ++ K+ A + ++D E +
Sbjct: 961 LELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEED- 1019
Query: 894 IRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQE 953
K+ G K L+++ +E LEQ++ R +L +A + + L +S+ ++ D+ E
Sbjct: 1020 ---KVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDL--E 1074
Query: 954 EGSSQGEDSVSGSQ-RISSIYAREALIEIDYGDLCEDLKDAQA-----EEEIKQEMNTLQ 1007
Q E+ + + +S + A+ ++ + +K+ QA EEEI+ E +TL+
Sbjct: 1075 NDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE-HTLR 1133
Query: 1008 QKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKE 1065
K+ +Q+S L R +LE + ++ +E S A + KK + F++++++
Sbjct: 1134 AKIEKQRSDLAR----------ELEEISERLEEASGATSAQIEMNKKREAEFQKMRRD 1181
Score = 71.6 bits (174), Expect = 4e-12
Identities = 89/442 (20%), Positives = 197/442 (44%), Gaps = 37/442 (8%)
Query: 673 KLKEKKERLTEELKEQMKAKRK-EAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNL 731
K+ K E+ T++L+ ++ ++K A+L + + + G + S DLE K + +
Sbjct: 1026 KINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQ-----I 1080
Query: 732 QEK-SKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIR 790
+EK K E EL+ +I+D + ++++K+L+ ++ ++E+E+ E +
Sbjct: 1081 EEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKI---- 1136
Query: 791 EFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIE 850
E + + R+ E +RLE + T Q++ K + E Q E+ + E
Sbjct: 1137 EKQRSDLARELEEISERLEEASGAT--SAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1194
Query: 851 KLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQK 910
L+K++ + + E + LQ +K + +KSE+ E++++ + +K +++++
Sbjct: 1195 TLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELK---MEIDDMASNIEALSKSKSNIER 1251
Query: 911 EVTAIE---TKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQ 967
+E ++++ K + L+ MQ +L G + +E+ S SQ
Sbjct: 1252 TCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLI-------SQ 1304
Query: 968 RISSIYAREALIEIDYGDLCEDLKD----AQAEEEIKQEMNTLQQKLNEQQSVLQRIAAP 1023
S A +E + E+ K A A + + + + L+++ E+Q +
Sbjct: 1305 LTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRA 1364
Query: 1024 NMKAMEKLESVRDKF-----QETSDEFEAARKRAKKAKQAFE--QIKKERFDRFNACFES 1076
KA ++ R K+ Q T + EA +K A++ ++A E + + +
Sbjct: 1365 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQR 1424
Query: 1077 VATNIDEIYKALSRNSSAQAFL 1098
+ ++++ + L R+ +A A L
Sbjct: 1425 LQGEVEDLMRDLERSHTACATL 1446
Score = 67.8 bits (164), Expect = 6e-11
Identities = 102/496 (20%), Positives = 203/496 (40%), Gaps = 99/496 (19%)
Query: 90 EDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGI-LIKARNFLVFQGAVESIAM--- 145
+ R F +V+ + K++ +L +E L L K RN ++ V+ +
Sbjct: 1449 KQRNFDKVLA--EWKQKLDESQAELEAAQKESRSLSTELFKMRN--AYEEVVDQLETLRR 1504
Query: 146 --KNPKERTA-LFEEISRSGELAQEYDKRKKEMVKAEEDTQFNY--------HRKKNIAA 194
KN +E + L E+I+ +G+ QE +K KK + + + D Q H + I
Sbjct: 1505 ENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILR 1564
Query: 195 ERKEAKQEKEEADRYQRLKDEVV--------RAQVQLQ-------------LFKLYHNEV 233
+ E Q K E DR KDE + RA LQ L E
Sbjct: 1565 VQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEG 1624
Query: 234 EIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEK----------- 282
++ ++ +L N+++ + +K + V+ +LK+ + L +R + +++
Sbjct: 1625 DLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGL 1684
Query: 283 ---EIKEKDSELNQ-KRPQYIKAKE--NTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDEL 336
E++E L Q +R + + +E + S +++ L + SL N +K K + D+ +
Sbjct: 1685 LLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKK---KLEADIAQC 1741
Query: 337 EKEMLSVEKARQEFEER---------MEEESQSQGRDLTLEENQVKK---------YHRL 378
+ E+ + + + EE+ M E + +D + ++KK HRL
Sbjct: 1742 QAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1801
Query: 379 KEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVET-------EAKIKQKLREIEEN 431
E ++++K + ++ LD+E+++ E E K+K+ + EE+
Sbjct: 1802 DEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEED 1861
Query: 432 QKRI-------EKLEEYITTSKQSLEEQKKLEG-------ELTEEVEMAKRRIDEINKEL 477
K I +KL+ + + K+ EE ++ + E+E A R D ++
Sbjct: 1862 HKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQV 1921
Query: 478 NQVMEQLGDARIDRQE 493
N++ + D + E
Sbjct: 1922 NKLRAKSRDVGSQKME 1937
Score = 55.5 bits (132), Expect = 3e-07
Identities = 53/252 (21%), Positives = 114/252 (45%), Gaps = 20/252 (7%)
Query: 195 ERKEAKQEKEEADRYQRLKD-EVVRAQVQLQLFKLYHNEV--EIEKLNKELASKNKEIEK 251
E +E K E+ +R +RL + E++ A ++QL + + +KL ++A E+E
Sbjct: 1688 ELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVEN 1747
Query: 252 DKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKK 311
+ E++ K+ + MM E+ + E++ + + Q +K ++ + ++
Sbjct: 1748 SIQESRNAEEKAKKAITDAA-MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1806
Query: 312 L--EAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRD----L 365
L + KK +Q + ++ + ++D +K K ++E +++E + D L
Sbjct: 1807 LALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNIL 1866
Query: 366 TLEE------NQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEA 419
L++ +VK Y R EEA ++A T + + + +R D+ E + + A
Sbjct: 1867 RLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRA 1926
Query: 420 KIK----QKLRE 427
K + QK+ E
Sbjct: 1927 KSRDVGSQKMEE 1938
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 127 bits (319), Expect = 7e-29
Identities = 222/1098 (20%), Positives = 457/1098 (41%), Gaps = 207/1098 (18%)
Query: 174 EMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADR-YQRLKDE----VVRAQVQLQLFKL 228
++ + EE+ Q + ++ + + E EE +R +Q+L +E + Q + +LF
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF-- 903
Query: 229 YHNEVEIEKLNKELASKNKEIEK---------------------DKKRM----DKVEDEL 263
E E++ LA+K +E+E+ +KK+M +E++L
Sbjct: 904 ----AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959
Query: 264 KEKKKELGKMMREQQQIEKEIKEKDSE---LNQKRPQYIKAKENTSHKI----KKLEAAK 316
E++ K+ E+ E +IK+ + E L + ++IK K+ +I +L +
Sbjct: 960 DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEE 1019
Query: 317 KSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEE------------------------ 352
+ +N K K++ + +LE+ + EK RQE E+
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID 1079
Query: 353 -------RMEEESQ---SQGRDLTLEENQVKKYHR------------------LKEEASK 384
+ EEE Q ++G D TL +N K R + +A K
Sbjct: 1080 ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEK 1139
Query: 385 RAATLAQELE--KFNRDQKADQDRLDLEERKKVETE-AKIKQKLREIEEN-QKRIEKLEE 440
+ L++ELE K + D E R K E E A++K+ L E +N + +I+ + +
Sbjct: 1140 QKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQ 1199
Query: 441 YITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRK 500
T+ + L EQ + +E K+ ++ NKEL ++ L + + E R++
Sbjct: 1200 RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAE-SEHKRKKLD 1258
Query: 501 AEIMESIKRLYPGSVYGRL-IDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQY 559
A++ E ++ G RL ++L + K N+ ++ ++EK G I++
Sbjct: 1259 AQVQELHAKVSEGD---RLRVELAEKASKLQNEL------DNVSTLLEEAEKKG---IKF 1306
Query: 560 IKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVC 619
K+ +++ T E L+E KL + + K +LQ
Sbjct: 1307 AKDAASLES--------QLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ------Q 1352
Query: 620 DNVEDARR------IAFGGHQRHKTVALD---GTLFQKSGVISGGASDLKAKARRWDEKA 670
+ E+AR+ +A +D GT+ D +A ++R +EKA
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKA 1412
Query: 671 V--DKLKEKKERLTEEL------------------KEQMK------------------AK 692
+ DKL++ K RL +EL K+Q K
Sbjct: 1413 LAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERD 1472
Query: 693 RKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIK 752
R EAE R+ +++A L L+ + E+ + ++ L + L S + G +++++
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR-ADMEDLMSSKDDVGKNVHELE 1531
Query: 753 RIIQSREREMKDLKEKMNQVEDEV----FEEFCREIGVRNIR-EFEEEKVKRQNEIAKKR 807
+ ++ E+++++++ ++ ++EDE+ + E+ ++ ++ +FE + R + +K+
Sbjct: 1532 KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKK 1591
Query: 808 LEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETM 867
Q L +L+ E+ Q E +K E +IE K +K + +
Sbjct: 1592 RLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQ 1651
Query: 868 AQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRH 927
AQ++D + + ++ ++ + +E KKL E+ LQ+E+ + E +R
Sbjct: 1652 AQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD 1711
Query: 928 NL----LQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEID- 982
L + + L + I+Q E + E S + + + R+ +++D
Sbjct: 1712 ELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQS---NMELLNDRFRKTTLQVDT 1768
Query: 983 -YGDLCEDLKDAQ----AEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAME-KLESVRD 1036
+L + AQ A ++++++ L+ KL E + ++ + A+E K+ + +
Sbjct: 1769 LNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEE 1828
Query: 1037 KFQETSDEFEAA----RKRAKKAKQAFEQIK---------KERFDRFNACFESVATNIDE 1083
+ ++ + E AA R+ KK K+ F Q++ KE+ ++ NA + + ++E
Sbjct: 1829 QLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE 1888
Query: 1084 IYKALSRNSSAQAFLGPE 1101
+ +R ++++ L E
Sbjct: 1889 AEEEATRANASRRKLQRE 1906
Score = 115 bits (287), Expect = 3e-25
Identities = 156/799 (19%), Positives = 337/799 (42%), Gaps = 115/799 (14%)
Query: 163 ELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQ 222
EL+++ ++ K+ E++ Q K +A E K +Q K E++ ++ D AQVQ
Sbjct: 1207 ELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLD----AQVQ 1262
Query: 223 LQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEK 282
+L+ E ++L ELA K +++ + +D V L+E +K+ K ++ +E
Sbjct: 1263 ----ELHAKVSEGDRLRVELAEKASKLQNE---LDNVSTLLEEAEKKGIKFAKDAASLES 1315
Query: 283 EIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRK------------ 330
++++ L ++ Q K N S +I++LE K SLQ Q+ ++ +
Sbjct: 1316 QLQDTQELLQEETRQ----KLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1371
Query: 331 -------------GDMDELEKEMLSVEKARQEFEERMEEES-------------QSQGRD 364
G ++ LE+ + K + +R+EE++ Q + D
Sbjct: 1372 QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD 1431
Query: 365 LTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQK 424
LT++ + ++ E+ K+ L E + + ++DR + E R+K + +
Sbjct: 1432 LTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARA 1491
Query: 425 LREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQL 484
L E E ++ E+ + + + L K G+ E+E +KR +++ +E+ +E+L
Sbjct: 1492 LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551
Query: 485 GDARIDRQESSRQQRKAEI-MESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMD 543
D + Q + + + E+ M+++K + + R + ++K ++ + +V + ++
Sbjct: 1552 ED---ELQATEDAKLRLEVNMQAMKAQFERDLQTR----DEQNEEKKRLLIKQV--RELE 1602
Query: 544 AIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPP 603
A + D K + K+ + + K DE +++L+ KL + Y+
Sbjct: 1603 AELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLR--KLQAQMKDYQ-- 1658
Query: 604 HIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKA 663
+ L+ A + D + A K +L+ + Q ++
Sbjct: 1659 ---RELEEARASR---DEI-----FAQSKESEKKLKSLEAEILQLQEELAS--------- 1698
Query: 664 RRWDEKAVDKLKEKKERLTEELKEQMKAKRKEA-ELRQVQSQAHGLQMRLKYSQSDLEQT 722
E+A +++++ L +E+ K E R+++++ L+ L+ QS++E
Sbjct: 1699 ---SERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL 1755
Query: 723 KTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCR 782
R LQ + L +ELA Q ER+ K+LK K+ ++E V +F
Sbjct: 1756 NDRFRKTTLQVDT-LNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKA 1814
Query: 783 EIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTV 842
I E K+ + E QL+ E + V E+ +
Sbjct: 1815 TISAL------EAKIGQLEE-----------------QLEQEAKERAAANKLVRRTEKKL 1851
Query: 843 KKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGAN 902
K+ ++E ++ ++ + +++ A+++ LK Q + E N +++++L A
Sbjct: 1852 KEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDAT 1911
Query: 903 KEMTHLQKEVTAIETKLEQ 921
+ L +EV+ ++ +L +
Sbjct: 1912 EANEGLSREVSTLKNRLRR 1930
Score = 84.3 bits (207), Expect = 6e-16
Identities = 143/730 (19%), Positives = 310/730 (42%), Gaps = 90/730 (12%)
Query: 382 ASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEY 441
A K A Q+L Q+ L L + K+K L+ + ++ K EE
Sbjct: 802 ARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEEL 861
Query: 442 ITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQL-GDARIDRQESSRQQRK 500
+ E+Q K+EGEL EE+E R+ ++ +E N + EQL + + + + R
Sbjct: 862 LKVK----EKQTKVEGEL-EEME---RKHQQLLEEKNILAEQLQAETELFAEAEEMRARL 913
Query: 501 AEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYI 560
A + ++ + L DL +++ + + I+ + +K + IQ +
Sbjct: 914 AAKKQELEEI--------LHDLESRVEEE----------EERNQILQNEKKKMQAHIQDL 955
Query: 561 KEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCD 620
+EQ E E LE + K+++++ L+++ + KK ++ D
Sbjct: 956 EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME---------D 1006
Query: 621 NVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKER 680
+ + ++ K +A + K V+ SDL+ + ++ +EK +L++ K +
Sbjct: 1007 RIAECSSQLAEEEEKAKNLA---KIRNKQEVM---ISDLEERLKK-EEKTRQELEKAKRK 1059
Query: 681 LTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLE------QTKTRHLALNLQEK 734
L E + + ++ ++Q+Q L+++L + +L+ +T H L+
Sbjct: 1060 LDGETTD------LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113
Query: 735 SKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEE 794
+L++++A K E++ +DL E++ ++ E+ E + +E
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL------EDTLDTTAAQQE 1167
Query: 795 EKVKRQNEIA--KKRLEFENQKTRLGIQLDFEKN-----QLKEDQDKVHMWEQTVKKDEN 847
+ KR+ E+A KK LE E + IQ +++ +L E ++ ++ ++K++
Sbjct: 1168 LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ 1227
Query: 848 EIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLG-GANKEMT 906
+E KE +K++ + A+ + + + A+ E++ K E + +R +L A+K
Sbjct: 1228 GLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN 1287
Query: 907 HLQKEVTAIE-------------TKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQE 953
L T +E LE + D LLQ Q + L +++
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347
Query: 954 EGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQ 1013
Q E+ + + A ++ + + +DL ++ EE K+++ L +
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL------LKDA 1401
Query: 1014 QSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNAC 1073
+++ QR+ + A +KLE +++ Q+ D+ ++ E+ K+++FD+ A
Sbjct: 1402 EALSQRLEEKAL-AYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEK-KQKKFDQLLAE 1459
Query: 1074 FESVATNIDE 1083
+S++ E
Sbjct: 1460 EKSISARYAE 1469
Score = 68.6 bits (166), Expect = 4e-11
Identities = 72/343 (20%), Positives = 156/343 (45%), Gaps = 22/343 (6%)
Query: 143 IAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRK---------KNIA 193
+ +K +E A E+ + LA K+K E+ + + Q K + +
Sbjct: 1593 LLIKQVRELEAELEDERKQRALAVA-SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQ 1651
Query: 194 AERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDK 253
A+ K+ ++E EEA R + + AQ + KL E EI +L +ELAS + +
Sbjct: 1652 AQMKDYQRELEEA----RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAE 1707
Query: 254 KRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLE 313
+ D++ DE+ ++ E++++E I + + EL +++ + +++
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVD 1767
Query: 314 AAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVK 373
L + +K +LE++ ++ QE E ++ + ++ L + Q++
Sbjct: 1768 TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE 1827
Query: 374 KYHRLKEEASKRAAT--LAQELEKFNRD---QKADQDRLDLEERKKVE-TEAKIKQKLRE 427
+ +L++EA +RAA L + EK ++ Q D+ R + ++++E A++KQ R+
Sbjct: 1828 E--QLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQ 1885
Query: 428 IEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRI 470
+EE ++ + ++ L++ + L+ EV K R+
Sbjct: 1886 LEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRL 1928
Score = 31.6 bits (70), Expect = 4.9
Identities = 36/209 (17%), Positives = 82/209 (39%), Gaps = 22/209 (10%)
Query: 139 AVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKA----------EEDTQFNYHR 188
A S A K+ R L + QE + K KA + + Q
Sbjct: 1775 AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEA 1834
Query: 189 KKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKE 248
K+ AA + + EK+ + + +++DE A + ++EK N + ++
Sbjct: 1835 KERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKE---------QMEKANARMKQLKRQ 1885
Query: 249 IEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHK 308
+E+ ++ + ++ ++EL + + +E+ + L + P + + +
Sbjct: 1886 LEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQ 1945
Query: 309 IKKLEAAKKSLQNAQKHYKKRKGDMDELE 337
+ LE A SL+ + + + D++E +
Sbjct: 1946 L-HLEGA--SLELSDDDTESKTSDVNETQ 1971
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 126 bits (317), Expect = 1e-28
Identities = 221/1089 (20%), Positives = 453/1089 (41%), Gaps = 188/1089 (17%)
Query: 87 EGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMK 146
EG + A++ V S + + + E +L++ + ++ L+ + E A K
Sbjct: 790 EGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQK 849
Query: 147 NPKERTALFEEISRSGELAQEYDKRKKEMV-KAEEDTQFNYHRKKNIAAERKEAKQEKEE 205
T L + +L Q+ +K+ EM K + TQ + ++ E+++ KQ E
Sbjct: 850 KDV-CTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVE 908
Query: 206 ADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKE 265
+ E + ++++ KL E I LN+E +K K EK +M+KV+ + KE
Sbjct: 909 KENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEK---KMEKVKQKAKE 965
Query: 266 KKKELGKMMREQQ-QIEKEIKEKDSELNQKRPQYIK-----AKENT---SHKIKKLEA-A 315
++ L K + +Q+ +++KE++ EL+QK Q+ A+ N+ S + +LE
Sbjct: 966 MQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ 1025
Query: 316 KKSLQNAQKHYKKRKGDMDEL-EKEMLSVEKARQEFEERMEEESQSQGRDLTLE------ 368
K+ +++ + +++ D+ + EK++ + QE E +E + + +L +
Sbjct: 1026 KEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGC 1085
Query: 369 --ENQVKKYHRLKEEASKRAATLAQELEKFNRDQ-------------KADQDRLDLEERK 413
E K+ LKEE K+ TL + E+ + KA ++L+++ K
Sbjct: 1086 EKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNK 1145
Query: 414 KVETEAKIKQKLREI----EENQKRIEKLEEYITT--------------SKQSLEEQ--- 452
++ ++++L E+ EE+++++ +L + T S +SLE++
Sbjct: 1146 SLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLE 1205
Query: 453 -KKLEGELTEEVEMAKRRIDEI----NKELNQVMEQLGDARIDRQESSRQQRKAEIMES- 506
KKL EL ++++ ++ + + EL + +A + R S Q R ++ E+
Sbjct: 1206 FKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRI-SHCQHRTTKVKEAL 1264
Query: 507 -IKRLYPGSVYGRLIDLC---------------QPTQKKYQIAVTKVLGKNMDAIIVDSE 550
IK + +L L Q +K+ QI K + ++++++ + E
Sbjct: 1265 LIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQI---KSMKADIESLVTEKE 1321
Query: 551 KTGRD-------------CIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDV 597
++ CI +K++ E + ELK K+ I
Sbjct: 1322 ALQKEGGNQQQAASEKESCITQLKKELSE----------NINAVTLMKEELKEKKVEISS 1371
Query: 598 IRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALD---------GTLFQK 648
+ + + LQ N++ E A + K LD TL ++
Sbjct: 1372 LSKQLTDLNVQLQ----NSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKE 1427
Query: 649 SGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEA-----ELRQVQS 703
D K W +KA + + + + +EL+ Q++ K KEA ++ ++
Sbjct: 1428 KISALEQVDDWSNKFSEWKKKAQSRFTQHQNTV-KELQIQLELKSKEAYEKDEQINLLKE 1486
Query: 704 QAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMK 763
+ R + ++E K++ +++S LE+EL + RI +++ I + E++
Sbjct: 1487 ELDQQNKRFDCLKGEMEDDKSKME----KKESNLETELKSQTARIMELEDHITQKTIEIE 1542
Query: 764 DLKEKM---NQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQ 820
L E + NQ +D +E +++ ++ +E EEK R E +K L ENQ + +
Sbjct: 1543 SLNEVLKNYNQQKDIEHKELVQKL--QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAE 1600
Query: 821 LDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAK 880
L+ +K +L+ V E+ +K E+ +E E+ A+L +LK + K
Sbjct: 1601 LETKKKELEHVNLSVKSKEEELKALEDRLES-------------ESAAKLAELKRKAEQK 1647
Query: 881 ----KSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQ 936
K ++ + E EE KK + ++ + TKL+++ + H L + K
Sbjct: 1648 IAAIKKQLLSQMEEKEEQYKK---------GTESHLSELNTKLQEREREVHILEEKLK-- 1696
Query: 937 DIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAE 996
SV SQ + I R A Y + E +
Sbjct: 1697 -------------------------SVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731
Query: 997 EEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAK 1056
+ +++++ LQ+ L E++ +LQR+ + + +R ++QE + E A + + +
Sbjct: 1732 KTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQ 1791
Query: 1057 QAFEQIKKE 1065
+++E
Sbjct: 1792 SMIGHLQEE 1800
Score = 113 bits (283), Expect = 1e-24
Identities = 208/975 (21%), Positives = 403/975 (41%), Gaps = 154/975 (15%)
Query: 156 EEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDE 215
E+ G L+Q DK + + + E+ Q + KK++ ++E EE D+Y
Sbjct: 170 EKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHL---QEEFDASLEEKDQY----IS 222
Query: 216 VVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMR 275
V++ QV L +L + + ++ L K L + E K + D E E G ++
Sbjct: 223 VLQTQVSLLKQRLRNGPMNVDVL-KPLPQLEPQAEVFTKEENPESD--GEPVVEDGTSVK 279
Query: 276 EQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDE 335
+ +++ +K +++ L + + KE + + EA ++ L + +K K D+
Sbjct: 280 TLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK-DLHM 338
Query: 336 LEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEE-------ASKRAAT 388
EK L + ++ + +E+ Q +G + + Q+ + +KEE K+ T
Sbjct: 339 AEKTKLITQ--LRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTT 396
Query: 389 LAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLR-----EIEENQKRIEKLEEYIT 443
+EL R+QK +R EE +K + A+ ++ R E++E K IEK T
Sbjct: 397 QGEEL----REQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEK-----T 447
Query: 444 TSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEI 503
+ ++ + Q++L E V++ K+ +E +L ++ E+ + Q R+ E
Sbjct: 448 SEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREF 507
Query: 504 MESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQ 563
E +K S + + Q +++ +A+ + L AI+ +SE RD Q
Sbjct: 508 QEQMKVALEKS-QSEYLKISQEKEQQESLALEE-LELQKKAILTESENKLRDLQQ----- 560
Query: 564 RGEPETFLPLDYLEVKPTDEK-LRELKGAK--LVIDVIRYEPPHIKKALQYACGNALVCD 620
E ET+ LE++ + EK L+E K L + + + H K+
Sbjct: 561 --EAETY-RTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMV-------- 609
Query: 621 NVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKER 680
++HKT L+ Q+ + + LK + + EK +K +++KE
Sbjct: 610 -------------EKHKT-ELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKET 655
Query: 681 LTEELKEQMKAKRKEAELRQVQSQAHGLQMRLK-YSQSDLEQTKTRHLALNLQE----KS 735
L ++ +++ QAH +M K + D++QT+ L+ L E +
Sbjct: 656 LLKD--------------KEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARH 701
Query: 736 KLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEE 795
KLE EL+ +KD +KM Q + +E +N + + +
Sbjct: 702 KLEEELS------------------VLKDQTDKMKQELEAKMDE------QKNHHQQQVD 737
Query: 796 KVKRQNEIAKKRLE--FENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLK 853
+ +++E++ +R E ++Q +L + L LKE Q V E +K+ E E++
Sbjct: 738 SIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQ--- 794
Query: 854 KEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVT 913
+ A+L ++ A + ++ ++++KL E L K+V
Sbjct: 795 -----------QASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVA 843
Query: 914 AIETKLEQ--KRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISS 971
+E + + D H + ++QD+ L K + + + +Q +S
Sbjct: 844 EVEAQKKDVCTELDAHKI----QVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQ 899
Query: 972 IYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQS---VLQRIAAPNMKAM 1028
++ L+E ++ Q E K+E+ L QKL+ ++ +L K
Sbjct: 900 EQTKQILVE-------KENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQ 952
Query: 1029 E-KLESVRDKFQETSDEF------EAARKRAKKAKQAFEQIKKERFDRFNA-CFESVATN 1080
E K+E V+ K +E + + A+ + + A E +KE+ +FNA E N
Sbjct: 953 EKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEK--QFNAKMLEMAQAN 1010
Query: 1081 IDEIYKALSRNSSAQ 1095
I A+SR + Q
Sbjct: 1011 SAGISDAVSRLETNQ 1025
Score = 106 bits (264), Expect = 2e-22
Identities = 177/823 (21%), Positives = 364/823 (44%), Gaps = 120/823 (14%)
Query: 153 ALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHR--KKNIAA-------ERKEAKQEK 203
+L E+ + L ++YD+ K E++ +D F K+ I+A K ++ +K
Sbjct: 1388 SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKK 1447
Query: 204 EEADRYQRLKDEVVRAQVQLQLF--KLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVED 261
+ R+ + ++ V Q+QL+L + Y + +I L +EL +NK R D ++
Sbjct: 1448 KAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNK-------RFDCLKG 1500
Query: 262 ELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQN 321
E+++ K KM +++ +E E+K + + + ++ +++ + K ++E SL
Sbjct: 1501 EMEDDKS---KMEKKESNLETELKSQTARI-------MELEDHITQKTIEIE----SLNE 1546
Query: 322 AQKHYKKRKG-DMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKE 380
K+Y ++K + EL +++ ++ +E + R++E + + LTLE NQV + +K
Sbjct: 1547 VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEE---KILTLE-NQV---YSMKA 1599
Query: 381 EASKRAATLAQELEKFNRDQKADQDRLD-LEERKKVETEAKIKQKLREIEENQKRIEKLE 439
E T +ELE N K+ ++ L LE+R + E+ AK+ + R+ E+ +I ++
Sbjct: 1600 ELE----TKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ---KIAAIK 1652
Query: 440 EYITTSKQSLEEQKK--LEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQ 497
+ + + + EEQ K E L+E ++ E +E++ + E+L + E+
Sbjct: 1653 KQLLSQMEEKEEQYKKGTESHLSE----LNTKLQEREREVHILEEKLKSVESSQSETLIV 1708
Query: 498 QRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCI 557
R A+ + + G + QK Y+ ++ VL +N+ ++ G++
Sbjct: 1709 PRSAKNVAAYTEQEEADSQGCV-------QKTYEEKIS-VLQRNLTEKEKLLQRVGQEKE 1760
Query: 558 QYIK---EQRGE-PETFLPLDYLEVKPTD---------EKLRELKGAKLVIDVIRYEPPH 604
+ + E R + E + L++ E K + E+L E +I E
Sbjct: 1761 ETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEG 1820
Query: 605 IKKALQYACGNALVCDNVEDARRIAFGGHQ--RHKTVALDGTLFQKSGVISGGASDLKAK 662
K +Q V D+V+ + Q K LD L ++ V
Sbjct: 1821 GKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEV----------- 1869
Query: 663 ARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAEL----RQVQSQAHGLQMRLKYSQSD 718
+++L K E+L + +QM + K EL + +S++H +Q +L +
Sbjct: 1870 ----HRVEMEELTSKYEKL--QALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEA 1923
Query: 719 LEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFE 778
LA +EK KL E+ D++ + + ++E++ LK++ +Q +E +
Sbjct: 1924 QHNDLEFKLAGAEREKQKLGKEIVRLQ---KDLRMLRKEHQQELEILKKEYDQEREEKIK 1980
Query: 779 EFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQ-KTRLGIQLDFEKNQLKEDQDKVHM 837
+ ++ +++ ++ + ++A+K E E K + + E L+ Q++ +
Sbjct: 1981 QEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETN- 2039
Query: 838 WEQTVKKDENEIEKLKKEEQRHMKIID----ETMAQLQDLKNQHLAKKSEVNDKNHEMEE 893
Q +KK + + LK+ +R+ +I+D E A+++DL+ Q E+ K + E
Sbjct: 2040 --QLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQ----LEELQKKYQQKLE 2093
Query: 894 IRKKLGGANKEMTHLQKEVTAIET-------KLEQKRSDRHNL 929
+ G N + LQ ++ T K ++ R HNL
Sbjct: 2094 QEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNL 2136
Score = 105 bits (262), Expect = 3e-22
Identities = 212/1036 (20%), Positives = 437/1036 (42%), Gaps = 178/1036 (17%)
Query: 163 ELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEK--EEADRYQRLKDEVVRAQ 220
E Q+ KR++ ++K ++T ++ + + KEA QE+ E +++KD + +
Sbjct: 282 ETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEK 341
Query: 221 VQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQI 280
+L + +L + IE+L ++ K I + K++M + L+ K++E+ Q+
Sbjct: 342 TKL-ITQLRDAKNLIEQLEQD---KGMVIAETKRQM---HETLEMKEEEIA-------QL 387
Query: 281 EKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDEL---- 336
IK+ ++ + R Q K++ ++LE A + Q ++ +K K +MDE
Sbjct: 388 RSRIKQMTTQGEELREQKEKSERAA---FEELEKALSTAQKTEEARRKLKAEMDEQIKTI 444
Query: 337 ----EKEMLSVE----KARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAAT 388
E+E +S++ + +QE + M++ S+ Q L++ K+ R ++E +K+ T
Sbjct: 445 EKTSEEERISLQQELSRVKQEVVDVMKKSSEEQ--IAKLQKLHEKELARKEQELTKKLQT 502
Query: 389 LAQE--------LEKFNRD------QKADQDRLDLEE---RKKV---ETEAKIKQKLREI 428
+E LEK + +K Q+ L LEE +KK E+E K++ +E
Sbjct: 503 REREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEA 562
Query: 429 EENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDAR 488
E + RI +LE + ++SL+E K +L +E K + NKE+ ++E+
Sbjct: 563 ETYRTRILELESSL---EKSLQENKNQSKDLAVHLEAEKNKH---NKEITVMVEK----H 612
Query: 489 IDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGK---NMDAI 545
ES + Q+ A E ++ L +++YQ + K+ K + +
Sbjct: 613 KTELESLKHQQDALWTEKLQVL----------------KQQYQTEMEKLREKCEQEKETL 656
Query: 546 IVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHI 605
+ D E + I+ + E+ L+ L+VK T EL+ + + +
Sbjct: 657 LKDKEIIFQAHIEEMNEKT--------LEKLDVKQT-----ELESLSSELSEVLKARHKL 703
Query: 606 KKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARR 665
++ L D ++ + H +D + + I LK + +
Sbjct: 704 EEELSVLKDQT---DKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQ 760
Query: 666 WDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKT- 724
+ ++ K KE + KR E EL+Q ++ Q Y + EQTK
Sbjct: 761 LELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQ---SYQSATHEQTKAY 817
Query: 725 -------RHLALNLQ-EKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEV 776
+ L+L+ E+ L ++A + D+ + + + +++DL +++ + E+
Sbjct: 818 EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877
Query: 777 FEEFCREIGVRNIREFEEEKV----KRQNEIAKKRLEFENQ--KTRLGIQLDFE--KNQL 828
++ V+++ + E K+ K Q + + +E EN + R G + + E +L
Sbjct: 878 EQK------VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKL 931
Query: 829 KEDQDKVHM----WEQTVKKDENEIEKLKK-----EEQRHMKIIDETMAQLQDLKNQHLA 879
+D +H+ +E K E ++EK+K+ +E K++D+ ++L+N L
Sbjct: 932 SAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALE 991
Query: 880 ---KKSEVNDKNHEMEEIRKK-LGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKM 935
K+ + N K EM + + A + QKE IE+ E R + ++++ +
Sbjct: 992 LSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKE--QIESLTEVHRRELNDVIS---I 1046
Query: 936 QDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRI------------SSIYAREALIEID- 982
+ KL + +I + + + ++ Q+I + +E ++ D
Sbjct: 1047 WEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDT 1106
Query: 983 -YGDLCEDLKD--------AQAEEEIKQEMNTLQQKLN----------EQQSVLQRIAAP 1023
+L E LK AQ E ++K + L+ LN EQ L+ +A
Sbjct: 1107 TLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEE 1166
Query: 1024 NMKAME----KLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVAT 1079
+ + + KL++ ++FQ E + K + F+++ +E + + C +
Sbjct: 1167 DKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
Query: 1080 NIDEIYKALSRNSSAQ 1095
++ L SS++
Sbjct: 1227 LLEAKTNELINISSSK 1242
Score = 103 bits (256), Expect = 1e-21
Identities = 195/1034 (18%), Positives = 438/1034 (42%), Gaps = 139/1034 (13%)
Query: 116 EYSEELEKLG--------ILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQE 167
+Y E+EKL L+K + ++FQ +E + N K L + + L+ E
Sbjct: 637 QYQTEMEKLREKCEQEKETLLKDKE-IIFQAHIEEM---NEKTLEKLDVKQTELESLSSE 692
Query: 168 YDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFK 227
+ K K EE+ + + E EAK + E+ + +Q+ D +++
Sbjct: 693 LSEVLKARHKLEEELSVLKDQTDKMKQEL-EAKMD-EQKNHHQQQVDSIIK--------- 741
Query: 228 LYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEK 287
+EV I++ K L K +++++E LKE+ K L + + +E +IK
Sbjct: 742 --EHEVSIQRTEKAL----------KDQINQLELLLKERDKHLKEHQAHVENLEADIKRS 789
Query: 288 DSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKAR 347
+ EL Q S K+ ++ + + K Y+++ + +L++++L +E R
Sbjct: 790 EGELQQ-----------ASAKLDVFQSYQSATHEQTKAYEEQ---LAQLQQKLLDLETER 835
Query: 348 QEFEERMEEESQSQGRDLTLEENQVK-KYHRLKEEASKRAATLAQELEKFNR--DQKADQ 404
+++ E ++Q +D+ E + K + L ++ K+ + + Q+++ + + K +
Sbjct: 836 ILLTKQV-AEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894
Query: 405 DRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVE 464
+ E+ K++ E K L+ E +K IE L + ++ + S+ L E + +
Sbjct: 895 GNKEQEQTKQILVE-KENMILQMREGQKKEIEILTQKLSAKEDSIH---ILNEEYETKFK 950
Query: 465 MAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQ 524
+++++++ ++ ++ E L +D++ +++ + +E ++ +++++ Q
Sbjct: 951 NQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQK--EKQFNAKMLEMAQ 1008
Query: 525 PTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYI----KEQRGEPETFLPLDYLEVKP 580
AV+++ + I +E R+ I K+ + E + ++++
Sbjct: 1009 ANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQE 1068
Query: 581 TDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVA 640
++++ ELK +K L + C + N E G Q
Sbjct: 1069 KEQEVAELK----------------QKILLFGCEKEEM--NKEITWLKEEGVKQDTTLNE 1110
Query: 641 LDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQ 700
L L QKS ++ A D ++ VD K KE L+EQ+ + AE +
Sbjct: 1111 LQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTF--LQEQLVELKMLAE--E 1166
Query: 701 VQSQAHGLQMRLKYSQSDLEQTKTRHLALN--LQEKS----KLESELA-NFGPRINDIKR 753
+ + L +LK + + + K+ H N L++KS KL ELA +
Sbjct: 1167 DKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
Query: 754 IIQSREREMKDL-KEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFEN 812
+++++ E+ ++ K N + + C+ ++E K +E+ + +
Sbjct: 1227 LLEAKTNELINISSSKTNAILSRI--SHCQH-RTTKVKEALLIKTCTVSELEAQLRQLTE 1283
Query: 813 QKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQD 872
++ L I +QL+E ++++ + ++ E E L+KE + E + +
Sbjct: 1284 EQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQ 1343
Query: 873 LK-------NQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTH---LQKEVTAIETKLEQK 922
LK N K E+ +K E+ + K+L N ++ + L ++ AI + +Q
Sbjct: 1344 LKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQY 1403
Query: 923 RSDRHNLLQACKMQDIKL---PLSKGTMDDISQEEGSS---------------QGEDSVS 964
++ LL ++QD+ LSK + + Q + S Q +++V
Sbjct: 1404 DEEKCELLD--QVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVK 1461
Query: 965 GSQRISSIYAREALIEIDYGDLCEDLKDAQAE--EEIKQEMNTLQQKLNEQQSVLQ-RIA 1021
Q + ++EA + + +L ++ D Q + + +K EM + K+ +++S L+ +
Sbjct: 1462 ELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELK 1521
Query: 1022 APNMKAME----------KLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFN 1071
+ + ME ++ES+ + + + + + K + Q F+++ +E+ +R
Sbjct: 1522 SQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVK 1581
Query: 1072 ACFESVATNIDEIY 1085
E + T +++Y
Sbjct: 1582 EAEEKILTLENQVY 1595
Score = 102 bits (253), Expect = 3e-21
Identities = 204/1024 (19%), Positives = 408/1024 (39%), Gaps = 133/1024 (12%)
Query: 146 KNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEE 205
K+ KE T L E++ LA+E ++ E+ + T + K+ + K K +++
Sbjct: 1145 KSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKS--SHEKSNKSLEDK 1202
Query: 206 ADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKEL----ASKNK----EIEKDKKRMD 257
+ +++L +E+ +QL + E +E EL +SK I + R
Sbjct: 1203 SLEFKKLSEELA---IQLDIC-CKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTT 1258
Query: 258 KVEDEL-------KEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIK 310
KV++ L E + +L ++ EQ + ++ +L +K Q K + +
Sbjct: 1259 KVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVT 1318
Query: 311 KLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEE---ESQSQGRDLTL 367
+ EA +K N Q+ +++ + +L+KE+ A +E ++E E S + LT
Sbjct: 1319 EKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTD 1378
Query: 368 EENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLRE 427
Q++ L E K AA L K ++K + LD + + + K+K+
Sbjct: 1379 LNVQLQNSISLSE---KEAAI--SSLRKQYDEEKCEL--LDQVQDLSFKVDTLSKEKISA 1431
Query: 428 IEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLG-- 485
+E+ K E+ ++ + + EL ++E+ + E ++++N + E+L
Sbjct: 1432 LEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
Query: 486 DARID--RQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQP-TQKKYQIAVTKVLGKNM 542
+ R D + E + K E ES S R+++L TQK +I + KN
Sbjct: 1492 NKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNY 1551
Query: 543 DAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEP 602
+ K +Q+ +E E + VK +EK+ L+ + ++ E
Sbjct: 1552 NQQKDIEHKELVQKLQHFQELGEEKDN-------RVKEAEEKILTLENQ---VYSMKAEL 1601
Query: 603 PHIKKALQYACGNALVCDNVEDARRIA--FGGHQRHKTVALDGTLFQKSGVISGGA-SDL 659
KK L++ N V E+ + + K L QK I S +
Sbjct: 1602 ETKKKELEHV--NLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQM 1659
Query: 660 KAKARRWDEKAVDKLKEKKERLTEE------LKEQMKA-KRKEAELRQVQSQAHGLQMRL 712
+ K ++ + L E +L E L+E++K+ + ++E V A +
Sbjct: 1660 EEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYT 1719
Query: 713 KYSQSDLE-------QTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMK-D 764
+ ++D + + K L NL EK KL R+ K S EM+
Sbjct: 1720 EQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQ-------RVGQEKEETVSSHFEMRCQ 1772
Query: 765 LKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFE 824
+E++ ++E ++ + + +++E EEK K+ + I + +E E K + + + E
Sbjct: 1773 YQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLE 1832
Query: 825 ------KNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQH- 877
+ L+E + + EQ +K+ ++ + + K+ + M+ + +LQ L+
Sbjct: 1833 NVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDG 1892
Query: 878 -------LAKKSEVNDKNHEME------------EIRKKLGGANKEMTHLQKEVTAIETK 918
L + +E K+H ++ ++ KL GA +E L KE+ ++
Sbjct: 1893 RNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKD 1952
Query: 919 LEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREAL 978
L R + L +I ++E + E+ + Q + L
Sbjct: 1953 LRMLRKEHQQEL------------------EILKKEYDQEREEKIKQEQEDLELKHNSTL 1994
Query: 979 IEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKF 1038
+ L + A++E + EM T+++ +N+ Q V + + E+ + K
Sbjct: 1995 KQ-----LMREFNTQLAQKEQELEM-TIKETINKAQEVEAELLESH---QEETNQLLKKI 2045
Query: 1039 QETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFL 1098
E D+ + KR +E+I R + A + T ++E+ K + +
Sbjct: 2046 AEKDDDLKRTAKR-------YEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENP 2098
Query: 1099 GPEN 1102
G +N
Sbjct: 2099 GNDN 2102
Score = 89.4 bits (220), Expect = 2e-17
Identities = 167/880 (18%), Positives = 366/880 (41%), Gaps = 130/880 (14%)
Query: 267 KKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHY 326
KK K+ EQQQ+++ + + N P ++++ TS ++L+ +
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSR--TSSFTEQLDEGTPN-------- 52
Query: 327 KKRKGDMDEL-EKEMLSVEKARQEFEERMEEES-QSQGRDLTLEENQVKKYHRLKEEASK 384
+ GD +K L V F ++E +S ++ + + + +RL ++S
Sbjct: 53 -RESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSST 111
Query: 385 RAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIE-KLEEYIT 443
+ +++ D + D L+ E+ + Q+LR +E + K E +T
Sbjct: 112 ASFDPPSDMDSEAEDLVGNSDSLNKEQ---------LIQRLRRMERSLSSYRGKYSELVT 162
Query: 444 TSKQSLEEQKKLEGELTEEVEMAKRRIDEINKEL------NQVMEQLGDARIDRQESSRQ 497
+ E+KKL+G L++ + + RRI E+ +EL + +++ DA ++ ++
Sbjct: 163 AYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYIS 222
Query: 498 QRKAEIMESIKRLYPGSVYGRLIDLCQP-TQKKYQIAV-TKVLGKNMDAIIVDSEKTGRD 555
+ ++ +RL G + +D+ +P Q + Q V TK D V + T
Sbjct: 223 VLQTQVSLLKQRLRNGPMN---VDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVK 279
Query: 556 CIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDV---IRYEPPHIKKALQYA 612
++ ++++ E L ++ E+ L K + R + K L A
Sbjct: 280 TLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMA 339
Query: 613 CGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVD 672
L+ + DA+ L L Q G++ + E+ +
Sbjct: 340 EKTKLI-TQLRDAKN-------------LIEQLEQDKGMVIAETKRQMHETLEMKEEEIA 385
Query: 673 KLKEKKERLT---EELKEQMKAKRKEA--ELRQVQSQAHGLQMRLKYSQSDLEQTKTRHL 727
+L+ + +++T EEL+EQ + + A EL + S A + + ++++++
Sbjct: 386 QLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIE 445
Query: 728 ALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVR 787
+ +E+ L+ EL+ + D+ + +S E ++ L++ + +E +++ R
Sbjct: 446 KTSEEERISLQQELSRVKQEVVDVMK--KSSEEQIAKLQKLHEKELARKEQELTKKLQTR 503
Query: 788 NIREFEEE-KV---KRQNEIAKKRLEFENQKTRLGIQLDFEK--------NQLKEDQDKV 835
REF+E+ KV K Q+E K E E Q++ +L+ +K N+L++ Q +
Sbjct: 504 E-REFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEA 562
Query: 836 HMWEQTVKKDENEIEK---------------LKKEEQRHMK----IIDETMAQLQDLKNQ 876
+ + + E+ +EK L+ E+ +H K ++++ +L+ LK+Q
Sbjct: 563 ETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQ 622
Query: 877 HLA---KKSEVNDKNH--EMEEIRKKLGGANKEM---------THLQ-------KEVTAI 915
A +K +V + + EME++R+K + + H++ +++
Sbjct: 623 QDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVK 682
Query: 916 ETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAR 975
+T+LE S+ +L+A + +L + K D + QE + E Q++ SI
Sbjct: 683 QTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKE 742
Query: 976 EALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQ-------QKLNEQQSVLQRIAAPNMKAM 1028
++ + E+ +K ++N L+ + L E Q+ ++ + A ++
Sbjct: 743 ------------HEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSE 790
Query: 1029 EKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFD 1068
+L+ K A ++ K ++ Q++++ D
Sbjct: 791 GELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLD 830
Score = 78.2 bits (191), Expect = 5e-14
Identities = 117/508 (23%), Positives = 225/508 (44%), Gaps = 54/508 (10%)
Query: 137 QGAVESIAMKNPKERTALFEE-ISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAE 195
QG V+ K +E+ ++ + ++ +L Q + K+E V + + + Y +++ I E
Sbjct: 1727 QGCVQ----KTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY-QERLIKLE 1781
Query: 196 RKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLN----KELASKNKEIEK 251
EAKQ ++++ L++E+ + L H E E K N + L + +++K
Sbjct: 1782 HAEAKQHEDQS-MIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQK 1840
Query: 252 DKKRMDKVEDELKEKKKELGKMMREQQQIEK----EIKEKDSELN-------QKRPQYIK 300
+ + L++K KEL + Q+++ + E+ K +L + +P +
Sbjct: 1841 TLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTEL- 1899
Query: 301 AKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMD--ELEKEMLSVEKARQEFEERMEEES 358
+ENT K K K L N + + + + E EK+ L E R + + RM +
Sbjct: 1900 LEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKE 1959
Query: 359 QSQGRDLTLEENQVKKYHRLKEEAS----KRAATLAQELEKFNRD--QKADQDRLDLEE- 411
Q ++ +E ++ ++K+E K +TL Q + +FN QK + + ++E
Sbjct: 1960 HQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKET 2019
Query: 412 -RKKVETEAKIKQKLREIEENQ---KRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAK 467
K E EA++ + +E E NQ K EK ++ T+K+ E E E+T +V +
Sbjct: 2020 INKAQEVEAELLESHQE-ETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQ 2078
Query: 468 RRIDEINKELNQVMEQ---LGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQ 524
+++E+ K+ Q +EQ G+ + E Q + + S +L ++ +L +
Sbjct: 2079 TQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNL-E 2137
Query: 525 PTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEK 584
KKY+ KN+ A V + G + GEP F +YL +
Sbjct: 2138 DRLKKYE--------KNVYATTVGTPYKGGNLYHTDVSLFGEPTEF---EYLRKVLFEYM 2186
Query: 585 L-RELKG-AKLVIDVIRYEPPHIKKALQ 610
+ RE K AK++ V+++ +K L+
Sbjct: 2187 MGRETKTMAKVITTVLKFPDDQTQKILE 2214
Score = 55.8 bits (133), Expect = 2e-07
Identities = 78/326 (23%), Positives = 149/326 (45%), Gaps = 52/326 (15%)
Query: 134 LVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIA 193
LV Q V + M+ E T+ +E++ + Q+ D R K EE+T+
Sbjct: 1863 LVRQKEVHRVEME---ELTSKYEKL----QALQQMDGRNKPTELLEENTE---------- 1905
Query: 194 AERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNK------ 247
EK ++ Q + AQ FKL E E +KL KE+ K
Sbjct: 1906 --------EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR 1957
Query: 248 -----EIEKDKKRMDKV-EDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKA 301
E+E KK D+ E+++K+++++L ++ +++ ++E +++L QK +
Sbjct: 1958 KEHQQELEILKKEYDQEREEKIKQEQEDL--ELKHNSTLKQLMREFNTQLAQKEQELEMT 2015
Query: 302 KENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQ 361
+ T +K +++EA + L++ Q+ + + E + ++ K +E + EEE ++
Sbjct: 2016 IKETINKAQEVEA--ELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAK 2073
Query: 362 GRDL--TLEENQVKKYHRLKEEASKRAATLA-QELEKFNRDQKADQDRLDLEERKKVETE 418
RDL LEE Q K +L++E + + EL+ Q A + L + + K E
Sbjct: 2074 VRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQ----TQLAQKTTLISDSKLK---E 2126
Query: 419 AKIKQKLREIEENQKRIEKLEEYITT 444
+ ++++ +E+ K+ EK Y TT
Sbjct: 2127 QEFREQIHNLEDRLKKYEK-NVYATT 2151
Score = 31.6 bits (70), Expect = 4.9
Identities = 49/275 (17%), Positives = 106/275 (38%), Gaps = 32/275 (11%)
Query: 850 EKLKKEEQRHMKIIDETMAQLQDLKNQHLAKK--SEVNDKNHEMEE--IRKKLGGANKEM 905
+KLK++ + + + +A Q N + S + +++E ++ G
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
Query: 906 THLQKEVTAIETKLEQ-------KRSDRHNLLQACKMQDI-KLPLSKGTMDDISQEEGSS 957
LQ V ++E+ + S + +L++ + + +L L T + S
Sbjct: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS 122
Query: 958 QGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVL 1017
+ ED V S ++ +E LI+ L + + E+ T Q L ++ L
Sbjct: 123 EAEDLVGNSDSLN----KEQLIQ----RLRRMERSLSSYRGKYSELVTAYQMLQREKKKL 174
Query: 1018 QRIAAPNM-KAMEKLESVRDKFQ-------ETSDEFEAARKRAKKAKQAFEQIKKERFDR 1069
Q I + + K++ ++ +R++ Q +EF+A+ + K + + + +
Sbjct: 175 QGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEE----KDQYISVLQTQVSL 230
Query: 1070 FNACFESVATNIDEIYKALSRNSSAQAFLGPENPE 1104
+ N+D + A+ F ENPE
Sbjct: 231 LKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPE 265
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 126 bits (317), Expect = 1e-28
Identities = 207/996 (20%), Positives = 435/996 (43%), Gaps = 147/996 (14%)
Query: 197 KEAKQEKEEA---DRYQRLKDEVV-----RAQVQLQLFKLYHNEVEIEKLNKELASKNKE 248
K A+ EKE A + +Q+ KDE+ R +++ ++ L + +++ + A +
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903
Query: 249 IEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHK 308
E+ +++ K + +L+ K KE+ + E+++I E+ K +L + + K ++
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELT 963
Query: 309 IKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLE 368
+ K+E K + +N K+ + +DE ++ +KA QE ++ + DL E
Sbjct: 964 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLD-------DLQAE 1016
Query: 369 ENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERK-KVETEAKIKQKLRE 427
E++V + K + ++ L LE+ ++K R+DLE K K+E + K+ Q+
Sbjct: 1017 EDKVNILTKAKTKLEQQVDDLEGSLEQ---EKKL---RMDLERAKRKLEGDLKLAQESTM 1070
Query: 428 IEENQK-----RIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVME 482
EN K ++EK E I+ +E+++ +E +L ++++ + RI+E+ +E+ E
Sbjct: 1071 DMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEA--E 1128
Query: 483 QLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNM 542
+ A+ ++Q S + EI E ++ G ++L + + ++Q + +
Sbjct: 1129 RASRAKAEKQRSDLSRELEEISERLEEA--GGATSAQVELNKKREAEFQKLRRDLEEATL 1186
Query: 543 --DAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLE-VKPTDEKLRELKGAKLVIDVIR 599
+A++ K D + + EQ +D L+ VK EK E K+ D +
Sbjct: 1187 QHEAMVAALRKKHADSMAELGEQ---------IDNLQRVKQKLEK--EKSELKMETDDLS 1235
Query: 600 YEPPHIKKALQYACGNA-LVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASD 658
I KA GN +C ++ED +++ + + L L + + A +
Sbjct: 1236 SNAEAISKAK----GNLEKMCRSLED--QVSELKTKEEEQQRLINDLTAQRARLQTEAGE 1289
Query: 659 LKAKARRWDEK--AVDKLKEKKERLT---EELKEQMK--AKRKEAELRQVQSQAHG---- 707
+R+ DEK V +L K+ T EELK Q++ K K A +QS H
Sbjct: 1290 Y---SRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLL 1346
Query: 708 -------------LQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRI 754
LQ L + S++ Q +T++ +Q +LE R+ + +
Sbjct: 1347 REQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEH 1406
Query: 755 IQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNI---------REFEE--EKVKRQNEI 803
+++ + L++ ++++EV E+ ++ N R F++ + K++ E
Sbjct: 1407 VEAVNAKCASLEKTKQRLQNEV-EDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEE 1465
Query: 804 AKKRLEFENQKTR-LGIQLDFEKNQLKEDQDKVHMWEQTVK-----------------KD 845
+ LE +++R L +L KN +E D++ + K K
Sbjct: 1466 TQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQ 1525
Query: 846 ENEIEKLKKE-EQRHMKI---IDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGA 901
+E+EK+KK+ EQ +I ++E A L+ + + L + E+N E++ +K+
Sbjct: 1526 IHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVD---RKIAEK 1582
Query: 902 NKEMTHLQKEVTAI----ETKLEQKRSDRHNLLQACKMQD-------IKLPLSKGTMDDI 950
++E+ L++ T + ++ L+ + R++ L+ K + I+L + +
Sbjct: 1583 DEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAES 1642
Query: 951 SQEEGSSQG---------EDSVSGSQ----RISSIYAREALIEIDYGDLCEDLKDAQ--- 994
+ ++QG +D++ G + +++ + R L++ + +L L+ +
Sbjct: 1643 LRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSR 1702
Query: 995 --AEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRA 1052
AE+E+ +Q + S++ + V + QE+ + E A+K
Sbjct: 1703 KIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAI 1762
Query: 1053 KKAKQAFEQIKKERFDRFNACFESVATNIDEIYKAL 1088
A E++KKE+ +A E + N+++ K L
Sbjct: 1763 TDAAMMAEELKKEQ--DTSAHLERMKKNLEQTVKDL 1796
Score = 90.5 bits (223), Expect = 9e-18
Identities = 177/873 (20%), Positives = 360/873 (41%), Gaps = 135/873 (15%)
Query: 113 QLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRK 172
++ E +E+LG I+A A + A K + + EEIS E A +
Sbjct: 1110 KIKELQARIEELGEEIEAER------ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQ 1163
Query: 173 KEMVKAEEDTQFNYHRKK----NIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKL 228
E+ K E +F R+ + E A K+ AD L +++ Q Q KL
Sbjct: 1164 VELNKKRE-AEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQ--KL 1220
Query: 229 YHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQI-------- 280
+ E++ +L+S + I K K ++K+ L+++ EL EQQ++
Sbjct: 1221 EKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQR 1280
Query: 281 ----------EKEIKEKD---SELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNA----- 322
+++ EKD S+L++ + + E H++++ AK +L +A
Sbjct: 1281 ARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSR 1340
Query: 323 ------QKHYKKRKGDMDELEKEMLSVEKARQEFEE-RMEEESQSQGRDLTLEENQVKKY 375
++ Y++ + EL++ ++ KA E + R + E+ + R LEE + K
Sbjct: 1341 HDCDLLREQYEEEQEGKAELQR---ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1397
Query: 376 HRLKEEASKRAATLA---------QELEKFNRDQKADQDR-------LDLEERKKVETEA 419
RL+E A A Q L+ D D +R LD ++R + +
Sbjct: 1398 QRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLS 1457
Query: 420 KIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQ 479
+ KQK EE Q +E ++ + L + K + E +++E +R + +E++
Sbjct: 1458 EWKQKY---EETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISD 1514
Query: 480 VMEQLGDA-----RIDRQESSRQQRKAEIMESIKRLYPGSVY--GRLIDLCQPTQKKYQI 532
+ EQ+ + +++ + +Q K EI +++ + G+++ + Q+
Sbjct: 1515 LTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKIL--------RIQL 1566
Query: 533 AVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAK 592
+ +V + +D I + ++ + Q + ET E++ ++ LR K K
Sbjct: 1567 ELNQVKSE-VDRKIAEKDE---EIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKK--K 1620
Query: 593 LVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVI 652
+ D+ E +Q N L +++ + R G + + LD L
Sbjct: 1621 MEGDLNEME-------IQLNHANRLAAESLRNYRNTQ--GILKETQLHLDDAL------- 1664
Query: 653 SGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAE---------LRQVQS 703
G DLK + + +A + L+ + E L L EQ + RK AE ++ + +
Sbjct: 1665 -RGQEDLKEQLAIVERRA-NLLQAEIEELWATL-EQTERSRKIAEQELLDASERVQLLHT 1721
Query: 704 QAHGLQMRLKYSQSDLEQTKTR-----HLALNLQEKSK--------LESELANFGPRIND 750
Q L K ++D+ Q ++ + N +EK+K + EL
Sbjct: 1722 QNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1781
Query: 751 IKRIIQSREREMKDLKEKMNQVEDEVFEEFCREI-----GVRNIREFEEEKVKRQNEIAK 805
++R+ ++ E+ +KDL+ ++++ E + ++I VR + E + KR E K
Sbjct: 1782 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVK 1841
Query: 806 KRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDE 865
+ E + L Q + ++ + QD V + VK + + E+ +++ ++ +
Sbjct: 1842 GLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRK 1901
Query: 866 TMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKL 898
+L++ + + +S+VN + E+ K+
Sbjct: 1902 LQHELEEAEERADIAESQVNKLRVKSREVHTKI 1934
Score = 88.6 bits (218), Expect = 3e-17
Identities = 165/843 (19%), Positives = 351/843 (41%), Gaps = 151/843 (17%)
Query: 134 LVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHR----- 188
L + V ++ K+ L E+I + Q+ +K K E+ +D N
Sbjct: 1186 LQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAK 1245
Query: 189 ---KKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLF------KLYHNEVEIEKLN 239
+K + + + K + + QRL +++ + +LQ +L + + +L+
Sbjct: 1246 GNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLS 1305
Query: 240 KELASKNKEIEKDKKRMDKVEDELKEKK---------KELGKMMREQQQIEKE------- 283
+ + ++IE+ K ++ E+E K K + ++REQ + E+E
Sbjct: 1306 RSKQASTQQIEELKHQL---EEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQR 1362
Query: 284 -IKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSL----QNAQKHYKKRKGDMDELEK 338
+ + +SE+ Q R +Y + + + ++LE AKK L Q A++H + LEK
Sbjct: 1363 ALSKANSEVAQWRTKY---ETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEK 1419
Query: 339 EMLSVEKARQEFEERMEEESQSQGRDLTLEENQ----------VKKYHRLKEE---ASKR 385
+ ++ + E E+ M + +S L++ Q +KY + E + K
Sbjct: 1420 ---TKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKE 1476
Query: 386 AATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTS 445
+ +L+ EL K + D+L+ R+ + +I +I E K+I +LE+
Sbjct: 1477 SRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKI---K 1533
Query: 446 KQSLEEQKKLEGELTE---EVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAE 502
KQ +E+ +++ L E +E + +I I ELNQV + +DR+ + K E
Sbjct: 1534 KQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSE-----VDRKIAE----KDE 1584
Query: 503 IMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKE 562
++ +KR + R+++ Q T +DA I ++ D ++ K+
Sbjct: 1585 EIDQLKRNHT-----RVVETMQST---------------LDAEI----RSRNDALRVKKK 1620
Query: 563 QRGE-PETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDN 621
G+ E + L++ + E LR + + +++ H+ AL+
Sbjct: 1621 MEGDLNEMEIQLNHAN-RLAAESLRNYRNTQ---GILKETQLHLDDALR----------G 1666
Query: 622 VEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERL 681
ED + ++ V L Q + ++R+ E+ + E+ + L
Sbjct: 1667 QEDLK-------EQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLL 1719
Query: 682 TEELKEQMKAKRK-EAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESE 740
+ + K+K E ++ Q+QS+ + + ++ ++ T A+ +E K +
Sbjct: 1720 HTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAIT-DAAMMAEELKKEQDT 1778
Query: 741 LANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIR----EFEEEK 796
A+ ++R+ ++ E+ +KDL+ ++++ E + ++I R E E E
Sbjct: 1779 SAH-------LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVEN 1831
Query: 797 VKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEE 856
+++N A K L ++ + +L + Q +ED+ V + V K + +++ K+
Sbjct: 1832 EQKRNAEAVKGLRKHERRVK---ELTY---QTEEDRKNVLRLQDLVDKLQAKVKSYKR-- 1883
Query: 857 QRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIE 916
Q ++ + Q A S+ HE+EE ++ A ++ L+ + +
Sbjct: 1884 ------------QAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVH 1931
Query: 917 TKL 919
TK+
Sbjct: 1932 TKI 1934
Score = 75.5 bits (184), Expect = 3e-13
Identities = 83/382 (21%), Positives = 171/382 (44%), Gaps = 27/382 (7%)
Query: 725 RHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVF--EEFCR 782
+ +A +E K + ELA + +++ + + +E DL+ ++ D + EE C
Sbjct: 850 KEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCE 909
Query: 783 EIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTV 842
++ I+ E K+K E A++ E + T +L+ E ++LK+D D + + V
Sbjct: 910 QLIKNKIQL--EAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV 967
Query: 843 KKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGAN 902
+K+++ E K M +DET+A+L K + D +++ K+
Sbjct: 968 EKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLD---DLQAEEDKVNILT 1024
Query: 903 KEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLS-KGTMDDISQEEGSSQGED 961
K T L+++V +E LEQ++ R +L +A + + L L+ + TMD E Q ++
Sbjct: 1025 KAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMD---MENDKQQLDE 1081
Query: 962 SVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEE-EIKQEMNTLQQKLNEQQSVLQRI 1020
+ E + +L ++D QA E ++++++ LQ ++ E ++
Sbjct: 1082 KLEKK-------------EFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAE 1128
Query: 1021 AAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATN 1080
A KA ++ + + +E S+ E A A A+ + ++ F + E
Sbjct: 1129 RASRAKAEKQRSDLSRELEEISERLEEA-GGATSAQVELNKKREAEFQKLRRDLEEATLQ 1187
Query: 1081 IDEIYKAL-SRNSSAQAFLGPE 1101
+ + AL +++ + A LG +
Sbjct: 1188 HEAMVAALRKKHADSMAELGEQ 1209
Score = 65.9 bits (159), Expect = 2e-10
Identities = 94/447 (21%), Positives = 202/447 (45%), Gaps = 92/447 (20%)
Query: 90 EDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGI---LIKARNFLVFQGAVESIAM- 145
+ R F +V+ SE+K + Q + + E + L K +N V++ +++ +
Sbjct: 1448 KQRNFDKVL----SEWKQKYEETQAELEASQKESRSLSTELFKVKN--VYEESLDQLETL 1501
Query: 146 ----KN-PKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAK 200
KN +E + L E+I+ G+ E +K KK++ + + + Q A E EA
Sbjct: 1502 RRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQ--------AALEEAEAS 1553
Query: 201 QEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKV- 259
E EE +++R Q++L N+V+ E +++++A K++EI++ K+ +V
Sbjct: 1554 LEHEEG--------KILRIQLEL-------NQVKSE-VDRKIAEKDEEIDQLKRNHTRVV 1597
Query: 260 ---EDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKR---PQYIKAKENTSHKIKKL- 312
+ L + + +R ++++E ++ E + +LN + ++ NT +K+
Sbjct: 1598 ETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQ 1657
Query: 313 ----------EAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQ--- 359
E K+ L ++ + +++EL + E++R+ E+ + + S+
Sbjct: 1658 LHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQ 1717
Query: 360 -----------------SQGRDLTLEENQVKKYHRLKEEASKRAAT----LAQELEKFNR 398
+ L E +V + R EE +K+A T +A+EL+K +
Sbjct: 1718 LLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKK-EQ 1776
Query: 399 DQKADQDRLDLEERKKVETEAK-IKQKLREIEE-----NQKRIEKLEEYITTSKQSLEEQ 452
D A +R+ +K +E K ++ +L E E+ +K+I+KLE + + +E +
Sbjct: 1777 DTSAHLERM----KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENE 1832
Query: 453 KKLEGELTEEVEMAKRRIDEINKELNQ 479
+K E + + +RR+ E+ + +
Sbjct: 1833 QKRNAEAVKGLRKHERRVKELTYQTEE 1859
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 126 bits (316), Expect = 1e-28
Identities = 199/995 (20%), Positives = 435/995 (43%), Gaps = 145/995 (14%)
Query: 197 KEAKQEKEEA---DRYQRLKDEVV-----RAQVQLQLFKLYHNEVEIEKLNKELASKNKE 248
K A+ EKE A + +Q++KDE+ R +++ ++ L + +++ + A +
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLAD 906
Query: 249 IEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHK 308
E+ ++ K + +L+ K KE+ + ++++I E+ K +L + + K ++
Sbjct: 907 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 966
Query: 309 IKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLE 368
+ K+E K + +N K+ + +DE ++ +KA QE ++ + DL E
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD-------DLQAE 1019
Query: 369 ENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEE-RKKVETEAKIKQKLRE 427
E++V + K + ++ L LE +++K R+DLE ++K+E + K+ Q+
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLE---QEKKL---RMDLERAKRKLEGDLKLAQESIM 1073
Query: 428 IEENQK-----RIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVME 482
EN+K +++K E I+ + +E+++ L +L ++++ + RI+E+ +E+ E
Sbjct: 1074 DIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE--AE 1131
Query: 483 QLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNM 542
+ A+ ++Q S + EI E ++ G I++ + + ++Q + +++
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEE--AGGATSAQIEMNKKREAEFQ-----KMRRDL 1184
Query: 543 DAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKL-RELKGAKLVIDVIRYE 601
+ + E T ++++ + L ++ +KL +E K+ ID +
Sbjct: 1185 EEATLQHEATAAT----LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1240
Query: 602 PPHIKKALQYACGN-ALVCDNVEDARRIAFGGHQRHKTVALD-----GTLFQKSGVISGG 655
+ KA GN +C +ED + + + D G L +SG S
Sbjct: 1241 VETVSKAK----GNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQ 1296
Query: 656 ASD---LKAKARRWDEKAVDKLKEKKERLTEELKEQ------MKAKRKEAEL-----RQV 701
+ L ++ R + +++E K +L EE+K + +++ R + +L +
Sbjct: 1297 LDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEE 1356
Query: 702 QSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSRERE 761
Q LQ L + +++ Q +T++ +Q +LE R+ + +++ +
Sbjct: 1357 QESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAK 1416
Query: 762 MKDLKEKMNQVEDEVFEEFCREIGVRNI---------REFEE--EKVKRQNEIAKKRLEF 810
L++ ++++EV E+ ++ N R F++ + K++ E LE
Sbjct: 1417 CASLEKTKQRLQNEV-EDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEA 1475
Query: 811 ENQKTR-LGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQ 869
++ R LG +L KN +E D++ ++ K + EI L ++ K I E
Sbjct: 1476 SQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE---- 1531
Query: 870 LQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNL 929
L+ +K Q +K E+ +EE L ++ +Q E+ +++++++K +++
Sbjct: 1532 LEKIKKQVEQEKCEL---QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1588
Query: 930 LQACKMQDIKLPLS-KGTMD-DISQEEGSSQGEDSVSGSQRISSI-------YAREALIE 980
+ K I++ S + T+D +I + + + + G I A EAL
Sbjct: 1589 IDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL-- 1646
Query: 981 IDYGDLCEDLKDAQ--------AEEEIKQEM-------NTLQQKLNEQQSVLQRIAAPNM 1025
+Y + LKD Q ++E++K+++ N LQ ++ E ++ L++
Sbjct: 1647 RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1706
Query: 1026 KAMEKLESVRDKFQ-------------------------ETSDEFEAARKRAKKAKQAF- 1059
A ++L ++ Q E D + AR +KAK+A
Sbjct: 1707 IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAIT 1766
Query: 1060 ------EQIKKERFDRFNACFESVATNIDEIYKAL 1088
E++KKE+ +A E + N+++ K L
Sbjct: 1767 DAAMMAEELKKEQ--DTSAHLERMKKNMEQTVKDL 1799
Score = 92.8 bits (229), Expect = 2e-18
Identities = 155/822 (18%), Positives = 332/822 (40%), Gaps = 130/822 (15%)
Query: 134 LVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHR----- 188
L + ++ K+ L E+I + Q+ +K K EM +D N
Sbjct: 1189 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248
Query: 189 ---KKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLF------KLYHNEVEIEKLN 239
+K + + K + + QRL +++ + +LQ +L E + +L+
Sbjct: 1249 GNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLS 1308
Query: 240 KELASKNKEIEKDKKRMDKVEDELKEKKKE-------------LGKMMREQQQIEKEIKE 286
+ + ++IE+ K+++ E+E+K K L + E+Q+ + E++
Sbjct: 1309 RGKQAFTQQIEELKRQL---EEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQR 1365
Query: 287 KDSELNQKRPQY-IKAKENTSHKIKKLEAAKKSL----QNAQKHYKKRKGDMDELEKEML 341
S+ N + Q+ K + + + ++LE AKK L Q A++H + LEK
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK--- 1422
Query: 342 SVEKARQEFEERMEEESQSQGRDLTLEENQ-------------VKKYHRLKEEASKRAAT 388
+ ++ + E E+ M + ++ L++ Q ++ H E + K A +
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS 1482
Query: 389 LAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQS 448
L EL K + D+L+ +R+ + +I +I E KRI +LE+ KQ
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI---KKQV 1539
Query: 449 LEEQKKLEGELTE---EVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRK--AEI 503
+E+ +L+ L E +E + +I I ELNQV ++ ++ E Q ++ I
Sbjct: 1540 EQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRI 1599
Query: 504 MESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQ 563
+ES++ + R I + K + +++ + + R + ++
Sbjct: 1600 VESMQSTLDAEIRSR----------NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNY 1649
Query: 564 RGEP----ETFLPLDYLEVKPTDEKLRE-LKGAKLVIDVIRYEPPHIKKALQYACGNALV 618
R +T + LD + + E L+E L + ++++ E ++ L+ + +
Sbjct: 1650 RNTQGILKDTQIHLD--DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKI 1707
Query: 619 CDN--VEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKE 676
+ ++ + R+ Q + L + G D+ +AR +EKA + +
Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITD 1767
Query: 677 KKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSK 736
+ EELK++ + AH L+ + ++EQT + L L L E +
Sbjct: 1768 -AAMMAEELKKEQ------------DTSAH-----LERMKKNMEQT-VKDLQLRLDEAEQ 1808
Query: 737 LESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEK 796
L ++ +++++ L+ ++ ++E EV E +
Sbjct: 1809 L----------------ALKGGKKQIQKLEARVRELEGEV-----------------ESE 1835
Query: 797 VKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEE 856
KR E K + E + L Q + ++ + QD V + VK + + E+ +++
Sbjct: 1836 QKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895
Query: 857 QRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKL 898
++ + +L++ + + +S+VN + E+ K+
Sbjct: 1896 NTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKV 1937
Score = 72.4 bits (176), Expect = 2e-12
Identities = 80/360 (22%), Positives = 165/360 (45%), Gaps = 46/360 (12%)
Query: 731 LQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKM-------NQVEDEV------- 776
L + ++ E E+A IK + E + K+L+EKM N ++ +V
Sbjct: 845 LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904
Query: 777 --FEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDK 834
EE C ++ I+ E K+K E A+ E + T +L+ E ++LK+D D
Sbjct: 905 ADAEERCDQLIKTKIQ--LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 962
Query: 835 VHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQL-QDLKNQHLAKKSEVNDKNHEMEE 893
+ + V+K+++ E K M +DET+A+L ++ K A + ++D E +
Sbjct: 963 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED- 1021
Query: 894 IRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQE 953
K+ K L+++V +E LEQ++ R +L +A + + L L++ ++ DI E
Sbjct: 1022 ---KVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENE 1078
Query: 954 EGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQA-EEEIKQEMNTLQQKLNE 1012
+ Q++ ++ E + +L ++D QA ++++++ LQ ++ E
Sbjct: 1079 K------------QQLDEKLKKK---EFEISNLQSKIEDEQALGIQLQKKIKELQARIEE 1123
Query: 1013 QQSVLQRIAAPNMKA-------MEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKE 1065
+ ++ A KA +LE + ++ +E A + KK + F++++++
Sbjct: 1124 LEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD 1183
Score = 64.7 bits (156), Expect = 5e-10
Identities = 88/427 (20%), Positives = 187/427 (43%), Gaps = 96/427 (22%)
Query: 101 GSSEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISR 160
G+ +KI N Y E L++L L + L +E + L E+I+
Sbjct: 1484 GTELFKIKNA------YEESLDQLETLKRENKNL-------------QQEISDLTEQIAE 1524
Query: 161 SGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQ 220
G+ E +K KK++ + + + Q A E EA E EE +++R Q
Sbjct: 1525 GGKRIHELEKIKKQVEQEKCELQ--------AALEEAEASLEHEEG--------KILRIQ 1568
Query: 221 VQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKR----MDKVEDELKEKKKELGKMMRE 276
++L N+V+ E +++++A K++EI++ K+ ++ ++ L + + +R
Sbjct: 1569 LEL-------NQVKSE-VDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 277 QQQIEKEIKEKDSELNQKRPQYIKAKENTSHK--------------IKKLEAAKKSLQNA 322
++++E ++ E + +LN +A N + ++ E K+ L
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV 1680
Query: 323 QKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQ------SQGRDLTL--------- 367
++ + +++EL + E++R+ E+ + + S+ +Q L
Sbjct: 1681 ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI 1740
Query: 368 -----EENQVKKYHRLKEEASKRAAT----LAQELEKFNRDQKADQDRLDLEERKKVETE 418
E + + R EE +K+A T +A+EL+K +D A +R+ +K +E
Sbjct: 1741 SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK-EQDTSAHLERM----KKNMEQT 1795
Query: 419 AK-IKQKLREIEE-----NQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDE 472
K ++ +L E E+ +K+I+KLE + + +E ++K E + + +RR+ E
Sbjct: 1796 VKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE 1855
Query: 473 INKELNQ 479
+ + +
Sbjct: 1856 LTYQTEE 1862
Score = 55.1 bits (131), Expect = 4e-07
Identities = 78/355 (21%), Positives = 161/355 (45%), Gaps = 59/355 (16%)
Query: 103 SEYKINNKVVQLHEYSE-ELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRS 161
+E + N ++L + E +L ++ I + N + + A++N + + ++
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE------ALRNYRNTQGILKDTQIH 1662
Query: 162 GELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKD-EVVRAQ 220
+ A + KE + E R + AE +E + E+ +R +++ + E++ A
Sbjct: 1663 LDDALRSQEDLKEQLAMVE------RRANLLQAEIEELRATLEQTERSRKIAEQELLDAS 1716
Query: 221 VQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMD-KVEDELKEKK---KELGKMMRE 276
++QL H + N L + K++E D +M ++ED L+E + ++ K + +
Sbjct: 1717 ERVQLL---HTQ------NTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITD 1767
Query: 277 QQQIEKEIK-EKDSELNQKRPQYIKAKENTSHKIKKL-----EAAKKSLQNAQKHYKKRK 330
+ +E+K E+D+ + +R K+N +K L EA + +L+ +K +K +
Sbjct: 1768 AAMMAEELKKEQDTSAHLER-----MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLE 1822
Query: 331 GDMDELEKEMLSVEKARQE-------FEERMEEESQSQGRD----LTLEE------NQVK 373
+ ELE E+ S +K E E R++E + D L L++ +VK
Sbjct: 1823 ARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVK 1882
Query: 374 KYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREI 428
Y R EEA +++ T + K + + ++R D+ E + K++ K RE+
Sbjct: 1883 SYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQ----VNKLRVKSREV 1933
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 126 bits (316), Expect = 1e-28
Identities = 199/995 (20%), Positives = 435/995 (43%), Gaps = 145/995 (14%)
Query: 197 KEAKQEKEEA---DRYQRLKDEVV-----RAQVQLQLFKLYHNEVEIEKLNKELASKNKE 248
K A+ EKE A + +Q++KDE+ R +++ ++ L + +++ + A +
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLAD 906
Query: 249 IEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHK 308
E+ ++ K + +L+ K KE+ + ++++I E+ K +L + + K ++
Sbjct: 907 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 966
Query: 309 IKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLE 368
+ K+E K + +N K+ + +DE ++ +KA QE ++ + DL E
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD-------DLQAE 1019
Query: 369 ENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEE-RKKVETEAKIKQKLRE 427
E++V + K + ++ L LE +++K R+DLE ++K+E + K+ Q+
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLE---QEKKL---RMDLERAKRKLEGDLKLAQESIM 1073
Query: 428 IEENQK-----RIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVME 482
EN+K +++K E I+ + +E+++ L +L ++++ + RI+E+ +E+ E
Sbjct: 1074 DIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE--AE 1131
Query: 483 QLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNM 542
+ A+ ++Q S + EI E ++ G I++ + + ++Q + +++
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEE--AGGATSAQIEMNKKREAEFQ-----KMRRDL 1184
Query: 543 DAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKL-RELKGAKLVIDVIRYE 601
+ + E T ++++ + L ++ +KL +E K+ ID +
Sbjct: 1185 EEATLQHEATAAT----LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1240
Query: 602 PPHIKKALQYACGN-ALVCDNVEDARRIAFGGHQRHKTVALD-----GTLFQKSGVISGG 655
+ KA GN +C +ED + + + D G L +SG S
Sbjct: 1241 VETVSKAK----GNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQ 1296
Query: 656 ASD---LKAKARRWDEKAVDKLKEKKERLTEELKEQ------MKAKRKEAEL-----RQV 701
+ L ++ R + +++E K +L EE+K + +++ R + +L +
Sbjct: 1297 LDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEE 1356
Query: 702 QSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSRERE 761
Q LQ L + +++ Q +T++ +Q +LE R+ + +++ +
Sbjct: 1357 QESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAK 1416
Query: 762 MKDLKEKMNQVEDEVFEEFCREIGVRNI---------REFEE--EKVKRQNEIAKKRLEF 810
L++ ++++EV E+ ++ N R F++ + K++ E LE
Sbjct: 1417 CASLEKTKQRLQNEV-EDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEA 1475
Query: 811 ENQKTR-LGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQ 869
++ R LG +L KN +E D++ ++ K + EI L ++ K I E
Sbjct: 1476 SQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE---- 1531
Query: 870 LQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNL 929
L+ +K Q +K E+ +EE L ++ +Q E+ +++++++K +++
Sbjct: 1532 LEKIKKQVEQEKCEL---QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1588
Query: 930 LQACKMQDIKLPLS-KGTMD-DISQEEGSSQGEDSVSGSQRISSI-------YAREALIE 980
+ K I++ S + T+D +I + + + + G I A EAL
Sbjct: 1589 IDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL-- 1646
Query: 981 IDYGDLCEDLKDAQ--------AEEEIKQEM-------NTLQQKLNEQQSVLQRIAAPNM 1025
+Y + LKD Q ++E++K+++ N LQ ++ E ++ L++
Sbjct: 1647 RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1706
Query: 1026 KAMEKLESVRDKFQ-------------------------ETSDEFEAARKRAKKAKQAF- 1059
A ++L ++ Q E D + AR +KAK+A
Sbjct: 1707 IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAIT 1766
Query: 1060 ------EQIKKERFDRFNACFESVATNIDEIYKAL 1088
E++KKE+ +A E + N+++ K L
Sbjct: 1767 DAAMMAEELKKEQ--DTSAHLERMKKNMEQTVKDL 1799
Score = 92.8 bits (229), Expect = 2e-18
Identities = 155/822 (18%), Positives = 332/822 (40%), Gaps = 130/822 (15%)
Query: 134 LVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHR----- 188
L + ++ K+ L E+I + Q+ +K K EM +D N
Sbjct: 1189 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248
Query: 189 ---KKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLF------KLYHNEVEIEKLN 239
+K + + K + + QRL +++ + +LQ +L E + +L+
Sbjct: 1249 GNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLS 1308
Query: 240 KELASKNKEIEKDKKRMDKVEDELKEKKKE-------------LGKMMREQQQIEKEIKE 286
+ + ++IE+ K+++ E+E+K K L + E+Q+ + E++
Sbjct: 1309 RGKQAFTQQIEELKRQL---EEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQR 1365
Query: 287 KDSELNQKRPQY-IKAKENTSHKIKKLEAAKKSL----QNAQKHYKKRKGDMDELEKEML 341
S+ N + Q+ K + + + ++LE AKK L Q A++H + LEK
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK--- 1422
Query: 342 SVEKARQEFEERMEEESQSQGRDLTLEENQ-------------VKKYHRLKEEASKRAAT 388
+ ++ + E E+ M + ++ L++ Q ++ H E + K A +
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS 1482
Query: 389 LAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQS 448
L EL K + D+L+ +R+ + +I +I E KRI +LE+ KQ
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI---KKQV 1539
Query: 449 LEEQKKLEGELTE---EVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRK--AEI 503
+E+ +L+ L E +E + +I I ELNQV ++ ++ E Q ++ I
Sbjct: 1540 EQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRI 1599
Query: 504 MESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQ 563
+ES++ + R I + K + +++ + + R + ++
Sbjct: 1600 VESMQSTLDAEIRSR----------NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNY 1649
Query: 564 RGEP----ETFLPLDYLEVKPTDEKLRE-LKGAKLVIDVIRYEPPHIKKALQYACGNALV 618
R +T + LD + + E L+E L + ++++ E ++ L+ + +
Sbjct: 1650 RNTQGILKDTQIHLD--DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKI 1707
Query: 619 CDN--VEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKE 676
+ ++ + R+ Q + L + G D+ +AR +EKA + +
Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITD 1767
Query: 677 KKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSK 736
+ EELK++ + AH L+ + ++EQT + L L L E +
Sbjct: 1768 -AAMMAEELKKEQ------------DTSAH-----LERMKKNMEQT-VKDLQLRLDEAEQ 1808
Query: 737 LESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEK 796
L ++ +++++ L+ ++ ++E EV E +
Sbjct: 1809 L----------------ALKGGKKQIQKLEARVRELEGEV-----------------ESE 1835
Query: 797 VKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEE 856
KR E K + E + L Q + ++ + QD V + VK + + E+ +++
Sbjct: 1836 QKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895
Query: 857 QRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKL 898
++ + +L++ + + +S+VN + E+ K+
Sbjct: 1896 NTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKV 1937
Score = 72.4 bits (176), Expect = 2e-12
Identities = 80/360 (22%), Positives = 165/360 (45%), Gaps = 46/360 (12%)
Query: 731 LQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKM-------NQVEDEV------- 776
L + ++ E E+A IK + E + K+L+EKM N ++ +V
Sbjct: 845 LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904
Query: 777 --FEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDK 834
EE C ++ I+ E K+K E A+ E + T +L+ E ++LK+D D
Sbjct: 905 ADAEERCDQLIKTKIQ--LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 962
Query: 835 VHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQL-QDLKNQHLAKKSEVNDKNHEMEE 893
+ + V+K+++ E K M +DET+A+L ++ K A + ++D E +
Sbjct: 963 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED- 1021
Query: 894 IRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQE 953
K+ K L+++V +E LEQ++ R +L +A + + L L++ ++ DI E
Sbjct: 1022 ---KVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENE 1078
Query: 954 EGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQA-EEEIKQEMNTLQQKLNE 1012
+ Q++ ++ E + +L ++D QA ++++++ LQ ++ E
Sbjct: 1079 K------------QQLDEKLKKK---EFEISNLQSKIEDEQALGIQLQKKIKELQARIEE 1123
Query: 1013 QQSVLQRIAAPNMKA-------MEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKE 1065
+ ++ A KA +LE + ++ +E A + KK + F++++++
Sbjct: 1124 LEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD 1183
Score = 64.7 bits (156), Expect = 5e-10
Identities = 88/427 (20%), Positives = 187/427 (43%), Gaps = 96/427 (22%)
Query: 101 GSSEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISR 160
G+ +KI N Y E L++L L + L +E + L E+I+
Sbjct: 1484 GTELFKIKNA------YEESLDQLETLKRENKNL-------------QQEISDLTEQIAE 1524
Query: 161 SGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQ 220
G+ E +K KK++ + + + Q A E EA E EE +++R Q
Sbjct: 1525 GGKRIHELEKIKKQVEQEKCELQ--------AALEEAEASLEHEEG--------KILRIQ 1568
Query: 221 VQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKR----MDKVEDELKEKKKELGKMMRE 276
++L N+V+ E +++++A K++EI++ K+ ++ ++ L + + +R
Sbjct: 1569 LEL-------NQVKSE-VDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 277 QQQIEKEIKEKDSELNQKRPQYIKAKENTSHK--------------IKKLEAAKKSLQNA 322
++++E ++ E + +LN +A N + ++ E K+ L
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV 1680
Query: 323 QKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQ------SQGRDLTL--------- 367
++ + +++EL + E++R+ E+ + + S+ +Q L
Sbjct: 1681 ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI 1740
Query: 368 -----EENQVKKYHRLKEEASKRAAT----LAQELEKFNRDQKADQDRLDLEERKKVETE 418
E + + R EE +K+A T +A+EL+K +D A +R+ +K +E
Sbjct: 1741 SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK-EQDTSAHLERM----KKNMEQT 1795
Query: 419 AK-IKQKLREIEE-----NQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDE 472
K ++ +L E E+ +K+I+KLE + + +E ++K E + + +RR+ E
Sbjct: 1796 VKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE 1855
Query: 473 INKELNQ 479
+ + +
Sbjct: 1856 LTYQTEE 1862
Score = 55.1 bits (131), Expect = 4e-07
Identities = 78/355 (21%), Positives = 161/355 (45%), Gaps = 59/355 (16%)
Query: 103 SEYKINNKVVQLHEYSE-ELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRS 161
+E + N ++L + E +L ++ I + N + + A++N + + ++
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE------ALRNYRNTQGILKDTQIH 1662
Query: 162 GELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKD-EVVRAQ 220
+ A + KE + E R + AE +E + E+ +R +++ + E++ A
Sbjct: 1663 LDDALRSQEDLKEQLAMVE------RRANLLQAEIEELRATLEQTERSRKIAEQELLDAS 1716
Query: 221 VQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMD-KVEDELKEKK---KELGKMMRE 276
++QL H + N L + K++E D +M ++ED L+E + ++ K + +
Sbjct: 1717 ERVQLL---HTQ------NTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITD 1767
Query: 277 QQQIEKEIK-EKDSELNQKRPQYIKAKENTSHKIKKL-----EAAKKSLQNAQKHYKKRK 330
+ +E+K E+D+ + +R K+N +K L EA + +L+ +K +K +
Sbjct: 1768 AAMMAEELKKEQDTSAHLER-----MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLE 1822
Query: 331 GDMDELEKEMLSVEKARQE-------FEERMEEESQSQGRD----LTLEE------NQVK 373
+ ELE E+ S +K E E R++E + D L L++ +VK
Sbjct: 1823 ARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVK 1882
Query: 374 KYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREI 428
Y R EEA +++ T + K + + ++R D+ E + K++ K RE+
Sbjct: 1883 SYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQ----VNKLRVKSREV 1933
>gi|19924129 RAD50 homolog isoform 1 [Homo sapiens]
Length = 1312
Score = 124 bits (311), Expect = 6e-28
Identities = 268/1327 (20%), Positives = 543/1327 (40%), Gaps = 222/1327 (16%)
Query: 16 KGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFV-LGEKTSNLRVKTLRDLIHGAPVGKPA 74
K +QII F T ++GPNG+GK+ +++ + ++ G+ + T +H V +
Sbjct: 20 KDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNT---FVHDPKVAQET 76
Query: 75 ANRAFVSMVYSEEGAEDRTFARVIV----GGSSEYKINNKVVQLHEYSEELEKLGILIKA 130
RA + + + + E R +V +E+K V+ ++ E+ + + +
Sbjct: 77 DVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEK-----VSLSS 131
Query: 131 RNFLVFQGAVESIAMKNPKERTALF-------EEISRSGELAQEYDK--RKKEMVKAEED 181
+ + + + S+ + +F +S L Q++D+ +KA E
Sbjct: 132 KCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALET 191
Query: 182 ----TQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQL----QLFKLYHNEV 233
Q + K E K KQ KE+A ++D++ + QL ++ K Y NE+
Sbjct: 192 LRQVRQTQGQKVKEYQMELKYLKQYKEKA---CEIRDQITSKEAQLTSSKEIVKSYENEL 248
Query: 234 EIEKLNKELASKNKEIEKDKKRMDKVEDELK---EKKKELGKMMRE-QQQIEKEIKEKDS 289
+ L ++ KEIE + ++ K+++E+K +KK++ K E ++++EK + D
Sbjct: 249 D------PLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDE 302
Query: 290 ELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDEL--EKEMLSVEKAR 347
+LN Y + K +KL + L+ K + + EL E+ L ++ R
Sbjct: 303 QLND---LYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADR 359
Query: 348 -QEFEERMEEESQSQGRDLTLE--------ENQVKKYHRLKEEASKRAATLAQEL----- 393
QE + QS L L+ E Q+K +H+L E + A A +L
Sbjct: 360 HQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFA 419
Query: 394 EKFN---------RDQKADQDR---LDLEERKKVETEAK-IKQKLREIEENQKRIEKLEE 440
EK RD+K R L E K + E K +K +L+++E + RI +L++
Sbjct: 420 EKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQ 479
Query: 441 YITTSKQSLEEQKKLEGELTEEVEM-----AKRRIDEINKELNQVMEQLG---------- 485
+ +++ L + +K T ++E+ K +D ++L+Q MEQL
Sbjct: 480 ELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQME 539
Query: 486 ---DARIDRQESSR--QQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGK 540
+ D+ E R + R ++ + S+ +P +L D K +I T+
Sbjct: 540 MLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNK--KQLEDWLH--SKSKEINQTRDRLA 595
Query: 541 NMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAK-LVIDVIR 599
++ + SE+ +K + + ++ ++KL ++ G++ D+ R
Sbjct: 596 KLNKELASSEQNKNHINNELKRKEEQLSSY-----------EDKLFDVCGSQDFESDLDR 644
Query: 600 YEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDL 659
+ K + Q A L ++ I + + +FQ + SDL
Sbjct: 645 LKEEIEKSSKQRA---MLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDL 701
Query: 660 KAKARRWDEK---AVDKLKEKKERLTEEL----KEQMKAKRKEAELRQVQSQAHGLQMRL 712
++K R +K +LK+K++R E L Q KE E+ +++++ + +
Sbjct: 702 QSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDI 761
Query: 713 KYSQSDLEQTKTRHLALNLQEKS------------KLESELANFGPRIN---------DI 751
+ ++D+E+ +T + +E+S + + EL + +I D+
Sbjct: 762 QRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDL 821
Query: 752 KRIIQSREREMKDLKEKMNQVEDEVFEEFCREI------GVRNIR----EFEEEKVKRQN 801
R +Q +E ++ + K++ V ++ E R++ +++++ E + EK++
Sbjct: 822 DRTVQQVNQEKQEKQHKLDTVSSKI--ELNRKLIQDQQEQIQHLKSTTNELKSEKLQIST 879
Query: 802 EIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMK 861
+ ++R + E Q L ++ ++K+ +++V E T++K + E E+L ++ K
Sbjct: 880 NL-QRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNK 938
Query: 862 IIDETMAQLQD-LKNQH------------------LAKKSEVNDKNHEMEEIRKKLGGAN 902
I + + +++ +KN H K++E+N ++ E K N
Sbjct: 939 IAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKIN 998
Query: 903 KEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSK--------GTMDDISQEE 954
++M ++++ I+T+ Q+R + NL + +++K + G M + +
Sbjct: 999 EDMRLMRQD---IDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKS 1055
Query: 955 GSSQGEDSVSGSQRISSI-YAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQ 1013
+ E+++ +R ++ R+ E + ++L++ Q + ++K E
Sbjct: 1056 EHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRD--------AEEKYREM 1107
Query: 1014 QSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNAC 1073
V M+ E + D + +T D+ K E+I K D + +
Sbjct: 1108 MIV--------MRTTELVNKDLDIYYKTLDQ-----AIMKFHSMKMEEINKIIRDLWRST 1154
Query: 1074 FESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEK 1133
+ EI N SA N L G A R R S G+K
Sbjct: 1155 YRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKG----DTALDMRGR----CSAGQK 1206
Query: 1134 TVAALALLFAIHS--YKPAPFFVLDEIDAALDNTNIGKVANYIKE-----QSTCNFQAIV 1186
+A+L + A+ LDE LD NI +A+ + E NFQ +V
Sbjct: 1207 VLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLV 1266
Query: 1187 ISLKEEF 1193
I+ E+F
Sbjct: 1267 ITHDEDF 1273
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.343
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,248,686
Number of Sequences: 37866
Number of extensions: 1993609
Number of successful extensions: 44343
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 735
Number of HSP's successfully gapped in prelim test: 1624
Number of HSP's that attempted gapping in prelim test: 11101
Number of HSP's gapped (non-prelim): 14904
length of query: 1233
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1119
effective length of database: 13,930,794
effective search space: 15588558486
effective search space used: 15588558486
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.