Search of human proteins with 30348972

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30348972 coiled-coil domain containing 62 isoform a [Homo
sapiens]
         (682 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30348972 coiled-coil domain containing 62 isoform a [Homo sap...  1351   0.0  
gi|75677376 coiled-coil domain containing 62 isoform b [Homo sap...  1321   0.0  
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...    80   6e-15
gi|71061468 centromere protein E [Homo sapiens]                        75   2e-13
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    74   3e-13
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    74   6e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    74   6e-13
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    74   6e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    74   6e-13
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             73   8e-13
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    73   1e-12
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    73   1e-12
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...    71   3e-12
gi|187761324 shootin1 isoform a [Homo sapiens]                         70   8e-12
gi|50511340 shootin1 isoform b [Homo sapiens]                          70   8e-12
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    69   1e-11
gi|188528616 testis specific, 10 [Homo sapiens]                        69   1e-11
gi|13376858 testis specific, 10 [Homo sapiens]                         69   1e-11
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    69   2e-11
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho...    68   3e-11
gi|32698688 citron [Homo sapiens]                                      68   3e-11
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho...    67   5e-11
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     67   7e-11
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom...    67   7e-11
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom...    67   7e-11
gi|42794779 myosin 18A isoform b [Homo sapiens]                        67   7e-11
gi|28416946 myosin 18A isoform a [Homo sapiens]                        67   7e-11
gi|31542634 filamin A interacting protein 1 [Homo sapiens]             66   1e-10
gi|38044112 restin isoform b [Homo sapiens]                            65   2e-10
gi|4506751 restin isoform a [Homo sapiens]                             65   2e-10

>gi|30348972 coiled-coil domain containing 62 isoform a [Homo
           sapiens]
          Length = 682

 Score = 1351 bits (3496), Expect = 0.0
 Identities = 682/682 (100%), Positives = 682/682 (100%)

Query: 1   MNPPAAFLAGRQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEE 60
           MNPPAAFLAGRQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEE
Sbjct: 1   MNPPAAFLAGRQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEE 60

Query: 61  DRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQK 120
           DRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQK
Sbjct: 61  DRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQK 120

Query: 121 ATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADC 180
           ATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADC
Sbjct: 121 ATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADC 180

Query: 181 SGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEI 240
           SGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEI
Sbjct: 181 SGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEI 240

Query: 241 IRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLN 300
           IRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLN
Sbjct: 241 IRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLN 300

Query: 301 FNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEA 360
           FNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEA
Sbjct: 301 FNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEA 360

Query: 361 MLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDLVEKHNLPWSLGGKTQIE 420
           MLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDLVEKHNLPWSLGGKTQIE
Sbjct: 361 MLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDLVEKHNLPWSLGGKTQIE 420

Query: 421 PENKITLCKIHTKSPKCHGTGVQNEGKQPSETPTLSDEKQWHDVSVYLGLTNCPSSKHPE 480
           PENKITLCKIHTKSPKCHGTGVQNEGKQPSETPTLSDEKQWHDVSVYLGLTNCPSSKHPE
Sbjct: 421 PENKITLCKIHTKSPKCHGTGVQNEGKQPSETPTLSDEKQWHDVSVYLGLTNCPSSKHPE 480

Query: 481 KLDVECQDQMERSEISCCQKNEACLGESGMCDSKCCHPSNFIIEAPGHMSDVEWMSIFKP 540
           KLDVECQDQMERSEISCCQKNEACLGESGMCDSKCCHPSNFIIEAPGHMSDVEWMSIFKP
Sbjct: 481 KLDVECQDQMERSEISCCQKNEACLGESGMCDSKCCHPSNFIIEAPGHMSDVEWMSIFKP 540

Query: 541 SKMQRIVRLKSGCTCSESICGTQHDSPASELIAIQDSHSLGSSKSALREDETESSSNKKN 600
           SKMQRIVRLKSGCTCSESICGTQHDSPASELIAIQDSHSLGSSKSALREDETESSSNKKN
Sbjct: 541 SKMQRIVRLKSGCTCSESICGTQHDSPASELIAIQDSHSLGSSKSALREDETESSSNKKN 600

Query: 601 SPTSLLIYKDAPAFNEKASIVLPSQDDFSPTSKLQRLLAESRQMVTDLELSTLLPISHEN 660
           SPTSLLIYKDAPAFNEKASIVLPSQDDFSPTSKLQRLLAESRQMVTDLELSTLLPISHEN
Sbjct: 601 SPTSLLIYKDAPAFNEKASIVLPSQDDFSPTSKLQRLLAESRQMVTDLELSTLLPISHEN 660

Query: 661 LTGSATNISHLCGRQKADTNTE 682
           LTGSATNISHLCGRQKADTNTE
Sbjct: 661 LTGSATNISHLCGRQKADTNTE 682


>gi|75677376 coiled-coil domain containing 62 isoform b [Homo
           sapiens]
          Length = 684

 Score = 1321 bits (3419), Expect = 0.0
 Identities = 671/681 (98%), Positives = 673/681 (98%), Gaps = 1/681 (0%)

Query: 1   MNPPAAFLAGRQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEE 60
           MNPPAAFLAGRQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEE
Sbjct: 1   MNPPAAFLAGRQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEE 60

Query: 61  DRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQK 120
           DRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQK
Sbjct: 61  DRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQK 120

Query: 121 ATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADC 180
           ATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADC
Sbjct: 121 ATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADC 180

Query: 181 SGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEI 240
           SGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEI
Sbjct: 181 SGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEI 240

Query: 241 IRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLN 300
           IRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLN
Sbjct: 241 IRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLN 300

Query: 301 FNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEA 360
           FNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEA
Sbjct: 301 FNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEA 360

Query: 361 MLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDLVEKHNLPWSLGGKTQIE 420
           MLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDLVEKHNLPWSLGGKTQIE
Sbjct: 361 MLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDLVEKHNLPWSLGGKTQIE 420

Query: 421 PENKITLCKIHTKSPKCHGTGVQNEGKQPSETPTLSDEKQWHDVSVYLGLTNCPSSKHPE 480
           PENKITLCKIHTKSPKCHGTGVQNEGKQPSETPTLSDEKQWHDVSVYLGLTNCPSSKHPE
Sbjct: 421 PENKITLCKIHTKSPKCHGTGVQNEGKQPSETPTLSDEKQWHDVSVYLGLTNCPSSKHPE 480

Query: 481 KLDVECQDQMERSEISCCQKNEACLGESGMCDSKCCHPSNFIIEAPGHMSDVEWMSIFKP 540
           KLDVECQDQMERSEISCCQKNEACLGESGMCDSKCCHPSNFIIEAPGHMSDVEWMSIFKP
Sbjct: 481 KLDVECQDQMERSEISCCQKNEACLGESGMCDSKCCHPSNFIIEAPGHMSDVEWMSIFKP 540

Query: 541 SKMQRIVRLKSGCTCSESICGTQHDSPASELIAIQDSHSLGSSKSALREDETESSSNKKN 600
           SKMQRIVRLKSGCTCSESICGTQHDSPASELIAIQDSHSLGSSKSALREDETESSSNKKN
Sbjct: 541 SKMQRIVRLKSGCTCSESICGTQHDSPASELIAIQDSHSLGSSKSALREDETESSSNKKN 600

Query: 601 SPTSLLIYKDAPAFNEKASIVLPSQDDFSPTSKLQRLLAESRQMVTDLELSTLLPISHEN 660
           SPTSLLIYKDAPAFNEKASIVLPSQDDFSPTSKLQRLLAESRQMVTDLELSTLLPISHEN
Sbjct: 601 SPTSLLIYKDAPAFNEKASIVLPSQDDFSPTSKLQRLLAESRQMVTDLELSTLLPISHEN 660

Query: 661 LTGSATNISHLCGRQKADTNT 681
           LTGSATN S +   + A  NT
Sbjct: 661 LTGSATNKSEV-PEESAQKNT 680


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 82/391 (20%), Positives = 167/391 (42%), Gaps = 26/391 (6%)

Query: 11   RQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQL--LSWEEDRQKVLT- 67
            ++   +E ++  + ++   L   I +L    K L +    HQQ L  L  EED+   LT 
Sbjct: 970  KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE---AHQQTLDDLQMEEDKVNTLTK 1026

Query: 68   ----LEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATH 123
                LE++   LEG L +  ++   L +  + LE +    Q +   T+   Q++ +K   
Sbjct: 1027 AKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKK 1086

Query: 124  SSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGK 183
                  +L+ + E      ++L  ++ +LQAR + L   I+ +     +A    +D S +
Sbjct: 1087 KEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1146

Query: 184  FKMLEHALRDA-----------KMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTE 232
             + +   L +A           K  E    K ++D ++     +     L++   +   E
Sbjct: 1147 LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAE 1206

Query: 233  NNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHN-LRQIYVK 291
              EQ + + R+KQ+      EL   +       E ++ AK+  E+    L + L +I  K
Sbjct: 1207 LGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTK 1266

Query: 292  QQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKS 351
            ++   + +N   E S +  +++    E S+ LD  +D  +S L         + E+ ++ 
Sbjct: 1267 EEEQQRLIN---ELSAQKARLHTESGEFSRQLD-EKDAMVSQLSRGKQAFTQQIEELKRQ 1322

Query: 352  LFKDQKFEAMLVQQNRSDKSSCDECKEKKQQ 382
            L ++ K ++ L    +S +  CD  +E+ ++
Sbjct: 1323 LEEETKAKSTLAHALQSARHDCDLLREQYEE 1353



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 65/293 (22%), Positives = 125/293 (42%), Gaps = 43/293 (14%)

Query: 55   LLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKAL--ESNQMECQT------- 105
            LL   E  +++  ++E   K + EL K     + L +K+  L  E N ++ Q        
Sbjct: 843  LLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADAL 902

Query: 106  --------ALQKTQLQLQ----EMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQ 153
                     L KT++QL+    E+ ++A     ++ +L A+   L +   EL   +  L+
Sbjct: 903  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962

Query: 154  ---AREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQ 210
               A+ +      + K K++ E +  + +   K    + AL++A             ++Q
Sbjct: 963  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA-------------HQQ 1009

Query: 211  KLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDE-LLN 269
             L  L++E +K+      KT    +  +    L+QEK     +L   +ER KRK E  L 
Sbjct: 1010 TLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEK-----KLCMDLERAKRKLEGDLK 1064

Query: 270  IAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKA 322
            +A+     T ++   L +   K++ ++  L   +E+ Q L      K++E +A
Sbjct: 1065 LAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQA 1117



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 73/343 (21%), Positives = 142/343 (41%), Gaps = 50/343 (14%)

Query: 69   EERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLS 128
            E+  + ++ E  K  E +     K K LE   +         QLQ+Q  A          
Sbjct: 850  EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALA------ 903

Query: 129  EDLEARNETLSNTLVELSAQVGQLQAR---EQALTTMIKLKDKDIIEAVNHIADCSGKFK 185
             D E R + L  T ++L A++ ++  R   E+ +   +  K + + +      +CS    
Sbjct: 904  -DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLED------ECSE--- 953

Query: 186  MLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNE---------- 235
             L+  + D ++    + KEK   + K+K L  E+  L E + + T E             
Sbjct: 954  -LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1012

Query: 236  ----QREEIIRLKQEKSCLH---DELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQI 288
                + +++  L + K+ L    D+L  ++E+EK+    L  AK K E    +L   ++ 
Sbjct: 1013 DLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLE---GDLKLAQES 1069

Query: 289  YVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKN 348
             +  ++D Q LN  ++  +  +     K+E+ +AL       + +L+    +++ + E  
Sbjct: 1070 TMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAE 1129

Query: 349  QKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKS 391
            + S  K +K         RSD S   E +E  ++++   G  S
Sbjct: 1130 RASRAKAEK--------QRSDLSR--ELEEISERLEEAGGATS 1162



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 76/356 (21%), Positives = 150/356 (42%), Gaps = 39/356 (10%)

Query: 42   KELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQM 101
            K+  D VA   +Q+ S +  +QK   LE+  S+L+ E++     + +++K     E    
Sbjct: 1198 KKHADSVAELGEQIDSLQRVKQK---LEKEKSELKMEINDLASNMETVSKAKANFEKMCR 1254

Query: 102  ECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTT 161
              +  L + + + +E  +     S     L   +   S  L E  A V QL   +QA T 
Sbjct: 1255 TLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQ 1314

Query: 162  MIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNK 221
             I+       E    + + +     L HAL+ A+  +  +++E+ + +Q+ KA      +
Sbjct: 1315 QIE-------ELKRQLEEETKAKSTLAHALQSARH-DCDLLREQYEEEQEAKA------E 1360

Query: 222  LKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDEL---LNIAKSKQERT 278
            L+  +++  +E  + R      K E     D +  T E E+ K +L   L  A+   E  
Sbjct: 1361 LQRGMSKANSEVAQWRT-----KYET----DAIQRTEELEEAKKKLAQRLQDAEEHVEAV 1411

Query: 279  NSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNH 338
            NS+  +L +   + Q++++ L  +VE S       D K         + D  L++ +  +
Sbjct: 1412 NSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQR-------NFDKVLAEWKQKY 1464

Query: 339  PKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVIT 394
             +   + E +QK   + +     L +   + + S D  +  K++   +  E S +T
Sbjct: 1465 EETQAELEASQK---ESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLT 1517



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 78/413 (18%), Positives = 167/413 (40%), Gaps = 48/413 (11%)

Query: 25   KQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKRTE 84
            ++ +EL+    +L  R ++  + V     +  S E+ +Q+   L+     L  ++ +   
Sbjct: 1385 QRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQR---LQNEVEDLMIDVERSNA 1441

Query: 85   IIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNETLSNTLVE 144
               +L KK +  +    E +   ++TQ +L E +QK + S  LS +L         +L  
Sbjct: 1442 ACIALDKKQRNFDKVLAEWKQKYEETQAEL-EASQKESRS--LSTELFKVKNAYEESLDH 1498

Query: 145  LSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAETCIVKE 204
            L      L+   + L   I    + I E   HI +     K L+H   + + +       
Sbjct: 1499 LET----LKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEAS 1554

Query: 205  KQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKR- 263
             +  + K+  +++E+N++K +++ K  E +   EE+ +LK+    + + +  T++ E R 
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEIDRKIAEKD---EELDQLKRNHLRVVESMQSTLDAEIRS 1611

Query: 264  KDELLNIAKSKQERTN--------------SELHNLRQIY-------------VKQQSDL 296
            +++ L I K  +   N                L NLR                ++ Q DL
Sbjct: 1612 RNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDL 1671

Query: 297  QFLNFNVENSQELIQMYDSKMEES-KALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKD 355
            +     VE    L+Q    ++  S +  +  R M   +L +   +V +   +N   +   
Sbjct: 1672 KEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTK 1731

Query: 356  QKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDLVEKHN 408
            +K E  + Q     +    E +  +++       K  IT +++  ++L ++ +
Sbjct: 1732 KKLETDISQIQGEMEDIVQEARNAEEK------AKKAITDAAMMAEELKKEQD 1778



 Score = 36.6 bits (83), Expect = 0.079
 Identities = 39/214 (18%), Positives = 89/214 (41%), Gaps = 14/214 (6%)

Query: 17   EVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLE 76
            E +IS I+ + +++       +++ K+     A+  ++L   ++    +  +++   +  
Sbjct: 1735 ETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTV 1794

Query: 77   GELHKRTEIIRSLT-----KKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDL 131
             +L  R +    L      K+++ LE+   E ++ ++  Q    E  +         ++L
Sbjct: 1795 KDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKEL 1854

Query: 132  EARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHAL 191
              + E     ++ L   V +LQ       T +K   +   EA         KF+ L+H L
Sbjct: 1855 TYQTEEDRKNILRLQDLVDKLQ-------TKVKAYKRQAEEAEEQSNVNLAKFRKLQHEL 1907

Query: 192  RDAKMAETCIVKEKQDYKQKLKALKIEVNKLKED 225
             +AK  E   + E Q  K ++K+ ++    + E+
Sbjct: 1908 EEAK--ERADIAESQVNKLRVKSREVHTKVISEE 1939


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 98/432 (22%), Positives = 184/432 (42%), Gaps = 65/432 (15%)

Query: 19   EISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGE 78
            E + +  +  EL+  + EL    K++ + + ++Q QL   E  ++  + LE+       E
Sbjct: 640  ESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQL---EAKKKMQVDLEKELQSAFNE 696

Query: 79   LHKRTEIIRS-----------LTKKVKALE---SNQMECQTALQKTQLQLQEMAQKATHS 124
            + K T +I             L  K+  L+   + ++E   AL++  + L E+    +  
Sbjct: 697  ITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEV 756

Query: 125  SLLSEDLEARNETLSNTLVE---LSAQVGQLQAREQALTTMI-KLKDKDIIEAVNHIA-- 178
              L ++++ ++E L     E   L ++V   ++R Q L   I K KD       N+ +  
Sbjct: 757  ERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTD 816

Query: 179  -----------DCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLN 227
                       D   K+KM+             + KE Q +   L ALK E++   ++L 
Sbjct: 817  QEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQ 876

Query: 228  EKTTENNEQREEIIRLKQEKSCLHDELLFTVEREK-------------------RKDELL 268
            EKT E  E+  E+ +LK++     D  L TVEREK                    KD+L 
Sbjct: 877  EKTREVQERLNEMEQLKEQLE-NRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLK 935

Query: 269  NIAKSKQ---ERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKA--- 322
             + +S Q   ++  S++H+   + +  Q  L+    +++  QE I    SK+ E  +   
Sbjct: 936  QLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNL 995

Query: 323  -LDSSRDMCLSDLENNHPKVDIKRE---KNQKSLFKDQKFEAMLVQQNRSDKSSCDECKE 378
             ++ +      + +     +D K++   KN ++L  D K +  +++Q R   S   E  E
Sbjct: 996  HMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVK-DNEIIEQQRKIFSLIQEKNE 1054

Query: 379  KKQQIDTVFGEK 390
             +Q +++V  EK
Sbjct: 1055 LQQMLESVIAEK 1066



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 88/403 (21%), Positives = 188/403 (46%), Gaps = 51/403 (12%)

Query: 17   EVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLE 76
            E EISTI+KQ   L+ +  +L+++ +E+ +            +E++  +  + E   K+ 
Sbjct: 1504 ETEISTIQKQ---LEAINDKLQNKIQEIYE------------KEEQFNIKQISEVQEKVN 1548

Query: 77   GELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNE 136
             EL +  E  ++    ++++ES  +E    LQ++Q ++Q M ++      + E L+   +
Sbjct: 1549 -ELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERD 1607

Query: 137  TLSNTLVELSAQVGQLQAREQALTTMIKLKD-KDIIEAVNHIADCSGKFKM--------- 186
             L     E+ A++ + Q +E     M  + + ++ +  + H+ +     K+         
Sbjct: 1608 QLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETEN 1667

Query: 187  --LEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEI---- 240
              L   L +       + KE+ D +   + LK+E ++LKE+L E  T + E++EE+    
Sbjct: 1668 IRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVH 1727

Query: 241  IRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLN 300
            + LK+ +  + D+L   V   ++ +E+ N+ K  +   ++    L+   +K Q +L+  +
Sbjct: 1728 MHLKEHQETI-DKLRGIV--SEKTNEISNMQKDLEHSNDA----LKAQDLKIQEELRIAH 1780

Query: 301  FNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEA 360
             +++  QE I      + E    D   +M   DLEN++ K+   +EK Q+    + +   
Sbjct: 1781 MHLKEQQETIDKLRGIVSEK--TDKLSNM-QKDLENSNAKL---QEKIQELKANEHQLIT 1834

Query: 361  MLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDL 403
            +    N + K    E ++ K+QI     +   +TLS +  ++L
Sbjct: 1835 LKKDVNETQK-KVSEMEQLKKQI-----KDQSLTLSKLEIENL 1871



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 79/387 (20%), Positives = 169/387 (43%), Gaps = 48/387 (12%)

Query: 19   EISTIEKQRKELQLLIGELKDRDK-----------ELNDMVAVHQQQLLSWEEDRQKVLT 67
            E+S  ++   EL+LL  +   +D             LN+     Q+++ S  ++R  + T
Sbjct: 1297 EVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKT 1356

Query: 68   LEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLL 127
            ++E    LE +  +  E IR    K++  +S Q +         L ++E   + T     
Sbjct: 1357 IKEA---LEVKHDQLKEHIRETLAKIQESQSKQEQ--------SLNMKEKDNETTKIVSE 1405

Query: 128  SEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKML 187
             E  + ++  L    +E+     +LQ     + ++ K  +KD ++ +  +         L
Sbjct: 1406 MEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAK--EKDDLQRLQEVLQSESD--QL 1461

Query: 188  EHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEK 247
            +  +++       IV +  + +++LK     + + +E +NE     +E+  EI  ++++ 
Sbjct: 1462 KENIKE-------IVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQL 1514

Query: 248  SCLHDELLFTVEREKRKDELLNIAK--SKQERTNSELHNLRQIYVKQQSDLQF------- 298
              ++D+L   ++    K+E  NI +    QE+ N EL   ++    + S LQ        
Sbjct: 1515 EAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVN-ELKQFKEHRKAKDSALQSIESKMLE 1573

Query: 299  LNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKF 358
            L   ++ SQE IQ+   + EE K +  +  +    L+ N  ++  K +++Q+  ++  K 
Sbjct: 1574 LTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKM 1633

Query: 359  EAMLVQQNRSDKSSCDECKEKKQQIDT 385
             A+    N + +  C E +  K+Q +T
Sbjct: 1634 TAV----NETQEKMC-EIEHLKEQFET 1655



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 67/336 (19%), Positives = 158/336 (47%), Gaps = 38/336 (11%)

Query: 23   IEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTL----EERCSKLEGE 78
            I   +K+L+     LK +D ++ + + +    L   +E   K+  +     ++ S ++ +
Sbjct: 1751 ISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKD 1810

Query: 79   LHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNETL 138
            L      ++   +++KA E   +  +  + +TQ ++ EM Q       L + ++ ++ TL
Sbjct: 1811 LENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQ-------LKKQIKDQSLTL 1863

Query: 139  SNTLVELSAQVGQLQAREQALTTMIKLKD--KDIIEAVNHIADCSGKFKMLEHALRDAKM 196
            S   +E      +L    + + +++K +D  + + E +    D       L+ +L++ K 
Sbjct: 1864 SKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERD------QLKESLQETKA 1917

Query: 197  AETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLF 256
             +  I +E +  +   K  K  V+KL+E ++EKT + ++ ++++ + K       DEL  
Sbjct: 1918 RDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSK-------DELQK 1970

Query: 257  TVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNF---NVENSQELIQMY 313
             ++  ++K+  L   K     ++ +++ + Q+  K+Q + Q L+     ++N Q   +++
Sbjct: 1971 KIQELQKKELQLLRVKEDVNMSHKKINEMEQL--KKQFEAQNLSMQSVRMDNFQLTKKLH 2028

Query: 314  DSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQ 349
            +S +EE + +   RD      E    K  +K E++Q
Sbjct: 2029 ES-LEEIRIVAKERD------ELRRIKESLKMERDQ 2057



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 77/368 (20%), Positives = 162/368 (44%), Gaps = 35/368 (9%)

Query: 14   IGSEVEISTIEKQRKELQLLIG-------ELKDRDKELNDMVAVHQQQL--LSWEEDRQK 64
            I  + +I ++ +++ ELQ ++        +LK   KE  +M   +Q++L  L  E  +Q+
Sbjct: 1039 IEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQ 1098

Query: 65   VLTLEER--CSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKAT 122
             +  +E+    K EGEL +  + +  + +K+K       E Q  L   Q ++ EM +K  
Sbjct: 1099 EIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKIN 1158

Query: 123  HSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSG 182
                L  +L+ +  TL +   E      +L    + + ++   K++ +++ +    +   
Sbjct: 1159 EIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSI--TKERKVLKELQKSFETE- 1215

Query: 183  KFKMLEHALRDAKMAETCIVKEKQDYK---QKLKALKIEVNKLKEDLNEKTTE--NNEQR 237
                 +H     +  E   ++ K++ K     LK  +  +++L+  ++EKT +  N +  
Sbjct: 1216 ----RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDL 1271

Query: 238  EEI-IRLKQEKSCLHD--ELLFTVEREKRKDELLN-IAKSKQERTNSELHNLRQIYVKQQ 293
            E+   +L++E   LH+  ELL  V+      E +N +    ++ T  +   L +I +++ 
Sbjct: 1272 EKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERL 1331

Query: 294  SDLQFLNFNVENSQELIQMYDSKMEESK----ALDSSRDMCLSDLENNHPKVDIKREKNQ 349
                 LN   + SQE I+    + +  K    AL+   D     +     K+   + K +
Sbjct: 1332 R----LNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE 1387

Query: 350  KSLFKDQK 357
            +SL   +K
Sbjct: 1388 QSLNMKEK 1395



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 58/323 (17%), Positives = 147/323 (45%), Gaps = 39/323 (12%)

Query: 22   TIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHK 81
            TI+K R  +     +L +  K+L +  A  Q+++   + +  +++TL++  ++ + ++ +
Sbjct: 1789 TIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSE 1848

Query: 82   RTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEM---AQKATHSSLLSEDLEARNETL 138
              ++ + +  +   L   ++E     QK    L+EM    ++  +   + E L+   + L
Sbjct: 1849 MEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQL 1908

Query: 139  SNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAE 198
              +L E  A+  ++Q +E     M+  + K+ ++ +                    K++E
Sbjct: 1909 KESLQETKARDLEIQ-QELKTARMLSKEHKETVDKLRE------------------KISE 1949

Query: 199  TCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTV 258
              I         ++  ++ +++K K++L +K  E  ++  +++R+K++ +  H + +  +
Sbjct: 1950 KTI---------QISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKK-INEM 1999

Query: 259  EREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDS-KM 317
            E+ K++ E  N++       N +L        K    L+ +    +   EL ++ +S KM
Sbjct: 2000 EQLKKQFEAQNLSMQSVRMDNFQLTK------KLHESLEEIRIVAKERDELRRIKESLKM 2053

Query: 318  EESKALDSSRDMCLSDLENNHPK 340
            E  + + + R+M   D +N+  K
Sbjct: 2054 ERDQFIATLREMIARDRQNHQVK 2076



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 84/366 (22%), Positives = 156/366 (42%), Gaps = 63/366 (17%)

Query: 92  KVKALESNQMECQTALQKTQLQLQEMAQKATHSSL--LSEDLEARNETLSNTLVELSAQV 149
           ++K  E N ++   AL++   + QEM      S+L  L +  E  N+ L N   ELS++V
Sbjct: 525 ELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLEN---ELSSKV 581

Query: 150 GQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALR-------------DAKM 196
             L+ +E  +  + +  D   +E +    D S   + +E   +             DAK 
Sbjct: 582 ELLREKEDQIKKLQEYIDSQKLENIK--MDLSYSLESIEDPKQMKQTLFDAETVALDAKR 639

Query: 197 AETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDE--- 253
               +  E  + K+K+K L     +++ D+    ++   +++  + L++E     +E   
Sbjct: 640 ESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITK 699

Query: 254 LLFTVEREKRKDELLNI-----AKSKQERTNSELHN---LRQIYVKQQSDLQFLNFNVEN 305
           L   ++ +  KD L N+         Q+  N E+     LR+  V   S+L+ L   VE 
Sbjct: 700 LTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALRE-EVILLSELKSLPSEVER 758

Query: 306 SQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKV-----DIKREK------------- 347
            ++ IQ    K EE   + S +D   S++ +   +V     +I + K             
Sbjct: 759 LRKEIQ---DKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKST 815

Query: 348 -----NQKSLFKD--QKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFT 400
                N K+L  D  QK++ +L +  R ++   +  KE  Q+ D+  G  ++ T  S  T
Sbjct: 816 DQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKE-AQKFDSSLG--ALKTELSYKT 872

Query: 401 KDLVEK 406
           ++L EK
Sbjct: 873 QELQEK 878



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 99/464 (21%), Positives = 193/464 (41%), Gaps = 69/464 (14%)

Query: 20   ISTIEKQRKELQLLIGELKD---------RDKELNDMVAVHQQQLL---------SWEED 61
            I  +EKQ KEL + I  L+          RD +LN  + +H +++L         S + +
Sbjct: 2199 IDEVEKQ-KELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTE 2257

Query: 62   RQKVLTLEERCSK-LEGELHKRTEIIRSLTKKVKALESNQMECQT---------ALQKTQ 111
             Q+VL+  +  ++ LE  L+ R +I +    K    + N   CQ          A+    
Sbjct: 2258 FQQVLSNRKEMTQFLEEWLNTRFDIEKL---KNGIQKENDRICQVNNFFNNRIIAIMNES 2314

Query: 112  LQLQEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDII 171
             + +E  + AT S    +DL++  E               L +  Q   T    K+  + 
Sbjct: 2315 TEFEE--RSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVT 2372

Query: 172  EAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTT 231
                 +   + K + LE++L +AK  E+ + KE +  K + K L++  N +   L  K  
Sbjct: 2373 SRATQLT--TEKIRELENSLHEAK--ESAMHKESKIIKMQ-KELEV-TNDIIAKLQAKVH 2426

Query: 232  ENN---EQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQI 288
            E+N   E+ +E I++ Q+K  L  +      +E+ +D  + + K   E+    + N ++ 
Sbjct: 2427 ESNKCLEKTKETIQVLQDKVALGAKPY----KEEIEDLKMKLVKIDLEK----MKNAKEF 2478

Query: 289  YVKQQSDLQFLNFNVENSQELIQMYDSKMEESK-ALDSSRDMCLSDLENNHPKVDIKREK 347
                + ++      VE  +E+I++    +  S+ A D+S    +S+  +  P        
Sbjct: 2479 ----EKEISATKATVEYQKEVIRLLRENLRRSQQAQDTS---VISEHTDPQPSNKPLTCG 2531

Query: 348  NQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDLVEKH 407
                + ++ K   +  +  R +K    E  + KQQ + +  +K+ +  ++    + V+  
Sbjct: 2532 GGSGIVQNTKALILKSEHIRLEK----EISKLKQQNEQLIKQKNELLSNNQHLSNEVKT- 2586

Query: 408  NLPWSLGGKTQIEPENKITLCKIHTKSPKCHGTGVQNEGKQPSE 451
               W    +T     +K   C+   KSPK  GT  + +   PS+
Sbjct: 2587 ---WK--ERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQ 2625


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 101/501 (20%), Positives = 208/501 (41%), Gaps = 41/501 (8%)

Query: 11   RQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQL--LSWEEDRQKVLT- 67
            ++   +E ++  + ++   L   I +L    K L +    HQQ L  L  EED+  +LT 
Sbjct: 969  KEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQE---THQQTLDDLQAEEDKVNILTK 1025

Query: 68   ----LEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATH 123
                LE++   LEG L +  ++   L +  + LE +    Q +    +   Q++ +K   
Sbjct: 1026 AKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEK 1085

Query: 124  SSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGK 183
                  +L ++ E      ++L  ++ +LQAR + L   I+ +     +A    +D S +
Sbjct: 1086 KEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRE 1145

Query: 184  FKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRL 243
             + +   L +A  A +  V+         K  + E  KL+ DL E T ++      +  L
Sbjct: 1146 LEEISERLEEAGGATSAQVELN-------KKREAEFQKLRRDLEEATLQHEAM---VAAL 1195

Query: 244  KQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNV 303
            +++ +    EL   ++  +R  + L   KS+ +    +L +  +   K + +L       
Sbjct: 1196 RKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNL------- 1248

Query: 304  ENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLV 363
               +++ +  + ++ E K  +  +   ++DL     +  ++ E  + S   D+K +A++ 
Sbjct: 1249 ---EKMCRSLEDQVSELKTKEEEQQRLINDLTAQRAR--LQTEAGEYSRQLDEK-DALVS 1302

Query: 364  QQNRSDKSSCDECKEKKQQIDTVFGEKSVIT---LSSIFTKDLVEKHNLPWSLGGKTQIE 420
            Q +RS ++S  + +E K Q++     K+ +     SS    DL+ +        GK +++
Sbjct: 1303 QLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLL-REQYEEEQEGKAELQ 1361

Query: 421  PENKITLCKIHTKSPKCHGTGVQNEGKQPSETPTLSDEKQWHDVSVYLGLTNCPS-SKHP 479
                    ++     K     +Q   +       L+   Q  +  V      C S  K  
Sbjct: 1362 RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTK 1421

Query: 480  EKLDVECQDQM---ERSEISC 497
            ++L  E +D M   ERS  +C
Sbjct: 1422 QRLQNEVEDLMLDVERSNAAC 1442



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 78/345 (22%), Positives = 138/345 (40%), Gaps = 56/345 (16%)

Query: 55   LLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQL 114
            LL   E  +++ T++E   K + EL K          K K LE   +         QLQ+
Sbjct: 842  LLKSAETEKEMATMKEEFQKTKDELAKS-------EAKRKELEEKMVTLLKEKNDLQLQV 894

Query: 115  QEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAR---EQALTTMIKLKDKDII 171
            Q  A           D E R E L    ++L A++ ++  R   E+ +   +  K + + 
Sbjct: 895  QSEADSLA-------DAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLE 947

Query: 172  EAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTT 231
            +      +CS     L+  + D ++    + KEK   + K+K L  E+  L         
Sbjct: 948  D------ECS----ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD-------- 989

Query: 232  ENNEQREEIIRLKQEKSCL---HDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQI 288
                  E I +L +EK  L   H + L  ++ E+ K  +L  AK+K E+   +L    + 
Sbjct: 990  ------ETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQ 1043

Query: 289  YVKQQSDLQFLNFNVENSQELIQMYDSKMEESK-ALDSSRDMCLSDLEN------NHPKV 341
              K + DL+     +E   +L Q     ME  K  LD   +    ++ N      +   V
Sbjct: 1044 EKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAV 1103

Query: 342  DIKREKNQKSLFK-----DQKFEAMLVQQNRSDKSSCDECKEKKQ 381
            +I+ +K  K L        ++ EA    + +++K   D  +E ++
Sbjct: 1104 EIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEE 1148



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 70/351 (19%), Positives = 143/351 (40%), Gaps = 36/351 (10%)

Query: 17   EVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQL-----LSWEEDRQKVLT---L 68
            E ++S ++ + +E Q LI +L  +   L      + +QL     L  +  R K  +   +
Sbjct: 1256 EDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQI 1315

Query: 69   EERCSKLEGELHKRTEIIRSLT----------KKVKALESNQMECQTALQKTQLQLQEMA 118
            EE   +LE E   +  +  +L           ++ +  +  + E Q AL K   ++ +  
Sbjct: 1316 EELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWR 1375

Query: 119  QK-ATHSSLLSEDLEARNETLSNTLVE-------LSAQVGQLQAREQALTTMIKLKDKDI 170
             K  T +   +E+LE   + L+  L E       ++A+   L+  +Q L   ++    D+
Sbjct: 1376 TKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDV 1435

Query: 171  IEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKT 230
              +    A    K +  +  L + K        E +  +++ ++L  E+ K+K    E  
Sbjct: 1436 ERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESL 1495

Query: 231  TENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYV 290
             +    R E   L+QE S L +++    E  K+  EL  I K  ++    E   ++    
Sbjct: 1496 DQLETLRRENKNLQQEISDLTEQI---AEGGKQIHELEKIKKQVEQ----EKCEIQAALE 1548

Query: 291  KQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKV 341
            + ++ L+     +   Q  +    S+++   A    +D  +  L+ NH +V
Sbjct: 1549 EAEASLEHEEGKILRIQLELNQVKSEVDRKIA---EKDEEIDQLKRNHTRV 1596



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 24/111 (21%), Positives = 54/111 (48%), Gaps = 11/111 (9%)

Query: 15   GSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQL----LSWEEDRQKVLTLEE 70
            G + +I  +E + +EL+  +   + R+ E    +  H++++       EEDR+ VL L++
Sbjct: 1810 GGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQD 1869

Query: 71   RCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKA 121
               KL+ +       ++S  ++ +  E       +  +K Q +L+E  ++A
Sbjct: 1870 LVDKLQAK-------VKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERA 1913



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 39/203 (19%), Positives = 88/203 (43%), Gaps = 17/203 (8%)

Query: 23   IEKQRKELQLLIGELKDRDKELNDMV--AVHQQQLLSWEEDRQKVL-----TLEERCSKL 75
            + + + E++ +I E ++ +++    +  A    + L  E+D    L      LE+    L
Sbjct: 1737 VSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1796

Query: 76   EGELHKRTEI-IRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEAR 134
            +  L +  ++ ++   K+++ LE+   E +  ++  Q +  E  +         ++L  +
Sbjct: 1797 QHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQ 1856

Query: 135  NETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDA 194
             E     ++ L   V +LQA+       +K   +   EA         KF+ L+H L +A
Sbjct: 1857 TEEDRKNVLRLQDLVDKLQAK-------VKSYKRQAEEAEEQSNANLSKFRKLQHELEEA 1909

Query: 195  KMAETCIVKEKQDYKQKLKALKI 217
            +  E   + E Q  K ++K+ ++
Sbjct: 1910 E--ERADIAESQVNKLRVKSREV 1930


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 96/429 (22%), Positives = 176/429 (41%), Gaps = 46/429 (10%)

Query: 11   RQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEE 70
            +Q +  E ++   E  R++LQL     + + K+L D + V   Q     ++R+    LEE
Sbjct: 950  QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK---LLEE 1006

Query: 71   RCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSED 130
            R S L   L +  E  ++LTK     ES   E +  L+K +   QE+ +       L   
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRK 1059

Query: 131  LEARNETLSNTLVELSAQVG----QLQAREQALTTMIKLKDKDIIE---AVNHIADCSGK 183
            LE         + +L AQ+     QL  +E+ L   +   D +I +   A+  I +  G 
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1119

Query: 184  FKMLEHALRDAKMAETCIVKEKQDYKQKLKALKI---------------------EVNKL 222
               L+  L   + A     K+K+D  ++L+ALK                      EV  L
Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1179

Query: 223  KEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSEL 282
            K+ L+E+T  +  Q +E   ++Q+ +   +EL   +E+ KR    L+  K   E+ N++L
Sbjct: 1180 KKALDEETRSHEAQVQE---MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236

Query: 283  HNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVD 342
                ++  + + +++     +E     +Q   SK  + +   +  +  +  L+N    V 
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKLEAQ---VQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293

Query: 343  IKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFG--EKSVITLSSIFT 400
                + +    K  K  A L  Q +  +    E   +K  + T     E+   +L     
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1353

Query: 401  KDLVEKHNL 409
            +++  K NL
Sbjct: 1354 EEMEAKQNL 1362



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 94/432 (21%), Positives = 184/432 (42%), Gaps = 71/432 (16%)

Query: 8    LAGRQNIGSE-------VEISTIEKQRKELQLLIG-----ELKDRDKELNDMVAVHQQQL 55
            LA  +NI S+        E    EK+ K L L        E K+  +  N M+    + L
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516

Query: 56   LSWEEDRQK-VLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQL 114
            +S ++D  K V  LE+    LE ++ +    +  L  +++A E  ++  +  +Q  + Q 
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576

Query: 115  QEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQA------REQALTTMIK---- 164
            +              DL+AR+E       +L  Q+ + +       +++AL    K    
Sbjct: 1577 ER-------------DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623

Query: 165  --LKDKDII---------EAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLK 213
              LKD ++          EA+  +     + K  +  L DA+ +   I    ++ ++K K
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683

Query: 214  ALKIEVNKLKEDL-------NEKTTENNEQREEIIRLKQEKSCLHDE----------LLF 256
            +L+ ++ +L+EDL        +   E  E  EE+      ++ L DE          L  
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1743

Query: 257  TVEREKRKDELLN--IAKSKQ--ERTNSELHNLRQIYVKQQSDLQFL-NFNVENSQELIQ 311
             +E E+   E ++  + K+ Q  E+ ++EL   R    K +S  Q L   N E   +L +
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803

Query: 312  MYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSL-FKDQKFEAMLVQQNRSDK 370
            M  +   + K+  ++ +  ++ LE    +   +++   KSL  KD+K + +L+Q    ++
Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV-EDER 1862

Query: 371  SSCDECKEKKQQ 382
               ++ KE+ ++
Sbjct: 1863 KMAEQYKEQAEK 1874



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 72/360 (20%), Positives = 147/360 (40%), Gaps = 43/360 (11%)

Query: 36   ELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKA 95
            E++ ++ EL       Q+     +E  QK   L E  + L+ +L   TE+          
Sbjct: 853  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY--------- 903

Query: 96   LESNQMECQTALQKTQLQ--LQEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQ 153
             E+ +M  + A +K +L+  L EM  +        + L+A  + ++  +++L  Q+ + +
Sbjct: 904  AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963

Query: 154  AREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLK 213
            A  Q L           +E V        K K LE  +         + KE++  ++++ 
Sbjct: 964  AARQKLQ----------LEKVT----AEAKIKKLEDEILVMDDQNNKLSKERKLLEERI- 1008

Query: 214  ALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKS 273
                       DL     E  E+ + + +LK +   +  EL   +++E++  + L   K 
Sbjct: 1009 ----------SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058

Query: 274  KQERTNSELHNLRQIYVKQQSDL--QFLNFNVENSQELIQMYDSKMEESKALDSSRDM-- 329
            K E   S+ H        Q ++L  Q      E    L ++ D   +++ AL   R++  
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118

Query: 330  CLSDLE---NNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTV 386
             +SDL+   ++      K EK ++ L ++ +     ++      ++  E + K++Q  TV
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 80/391 (20%), Positives = 166/391 (42%), Gaps = 53/391 (13%)

Query: 22   TIEKQRKELQ---LLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLT-LEERCSKLEG 77
            T+EK+  +L     ++G+ K   +     +    Q+L S   D ++    L ++  KL+ 
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287

Query: 78   ELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNET 137
            E+   T ++     K   L  +     + LQ TQ  LQE  ++  + S     LE    +
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1347

Query: 138  LSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMA 197
            L + L E      +++A+ Q L   I   +  + ++   + D +   + LE      K  
Sbjct: 1348 LQDQLDE------EMEAK-QNLERHISTLNIQLSDSKKKLQDFASTVEALEEG---KKRF 1397

Query: 198  ETCIVKEKQDYKQKLKA---LKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDEL 254
            +  I    Q Y++K  A   L+   N+L+++L++   + + QR+ +  L ++K    D+L
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL-EKKQRKFDQL 1456

Query: 255  L---------FTVEREK-------RKDELLNIAKSKQE--RTNSELHNLRQIYVKQQSDL 296
            L         +  ER++       ++ + L++A++ +E      EL    ++   +  DL
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516

Query: 297  ----QFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSL 352
                  +  NV   ++  +  +++MEE K         L +LE      D  +      L
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQ-------LEELE------DELQATEDAKL 1563

Query: 353  FKDQKFEAMLVQQNRSDKSSCDECKEKKQQI 383
              +   +A+  Q  R  ++  ++ +EK++Q+
Sbjct: 1564 RLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 78/441 (17%), Positives = 184/441 (41%), Gaps = 36/441 (8%)

Query: 18   VEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEG 77
            +++S  +K+ ++    +  L++  K     +    QQ   +EE       LE+  ++L+ 
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ---YEEKAAAYDKLEKTKNRLQQ 1427

Query: 78   ELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNET 137
            EL      + +  + V  LE  Q +    L + +    + A +   +   + + E +  +
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487

Query: 138  LSNTLVELSAQVGQLQAREQALTT--MIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAK 195
            L+  L E       L+A+E+   T  M+K + +D++ + + +     + +  + AL    
Sbjct: 1488 LARALEEA------LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541

Query: 196  MAETCIVKEKQDYKQKLK--ALKIEVN------KLKEDLNEKTTENNEQREEIIR-LKQE 246
                  ++E +D  Q  +   L++EVN      + + DL  +  +N E+R ++ R L + 
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601

Query: 247  KSCLHDE----LLFTVEREKRKDELLNI---AKSKQERTNSELHNLRQIYVKQQSDLQFL 299
            ++ L DE     L    ++K + +L ++   A S  +     +  LR++  + +   + L
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661

Query: 300  NFNVENSQELIQMYDSKMEESKALDSSRDMCLSDL---ENNHPKVDIKREKNQKSLFKDQ 356
                 +  E+        +++K+L++       DL   E    + D+++E+  + L    
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721

Query: 357  KFEAMLVQQNRSDKSSC----DECKEKKQQIDTVFG--EKSVITLSSIFTKDLVEKHNLP 410
                 L  + R  ++      +E +E++  ++ +     K+      +  +   E+    
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781

Query: 411  WSLGGKTQIEPENKITLCKIH 431
             +   + Q+E +NK    K+H
Sbjct: 1782 KNESARQQLERQNKELRSKLH 1802



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 85/440 (19%), Positives = 179/440 (40%), Gaps = 71/440 (16%)

Query: 17   EVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLS----WEEDRQKVLTLEERC 72
            E E+   ++++++ +  + EL+ +  +L +   + Q+QL +    + E  +  + L  + 
Sbjct: 858  EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 917

Query: 73   SKLEGELHK----------RTEIIRSLTKKVKA----LESNQMECQTALQKTQLQ---LQ 115
             +LE  LH+          R + +++  KK+      LE    E + A QK QL+    +
Sbjct: 918  QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 977

Query: 116  EMAQKATHSSLLSED-----------LEARNETLSNTLVE------------------LS 146
               +K     L+ +D           LE R   L+  L E                  +S
Sbjct: 978  AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037

Query: 147  AQVGQLQAREQALTTMIKLKDK---DIIEAVNHIADCSGKFKML-------EHALRDAKM 196
                +L+  E++   + KLK K   D  +    IAD   +   L       E  L+ A  
Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1097

Query: 197  AETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLF 256
                 + +K +  +K++ L+  ++ L+EDL+ +    N+  ++   L +E   L  EL  
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157

Query: 257  TVE--------REKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQE 308
            T++        R KR+ E+  + K+  E T S    ++++  K    ++ L   +E  + 
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217

Query: 309  LIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRS 368
                 D   +  +  ++     L  L     +V+ K++K +  +   Q+ ++      R+
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV---QELQSKCSDGERA 1274

Query: 369  DKSSCDECKEKKQQIDTVFG 388
                 D+  + + ++++V G
Sbjct: 1275 RAELNDKVHKLQNEVESVTG 1294



 Score = 33.1 bits (74), Expect = 0.87
 Identities = 37/194 (19%), Positives = 84/194 (43%), Gaps = 9/194 (4%)

Query: 209  KQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELL 268
            +++++A + E+ K KE   +   E  E  ++  +L +EK+ L ++L    E     +E+ 
Sbjct: 851  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910

Query: 269  NIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRD 328
                +K++     LH +     +++   Q L    +   + +   + ++EE +A      
Sbjct: 911  VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK-- 968

Query: 329  MCLSDLENNHPKVDIKREKNQKSLFKDQ----KFEAMLVQQNRSDKSSCDECKEKKQQID 384
                 LE    +  IK+ +++  +  DQ      E  L+++  SD ++    +E+K +  
Sbjct: 969  ---LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025

Query: 385  TVFGEKSVITLSSI 398
            T    K    +S +
Sbjct: 1026 TKLKNKHESMISEL 1039



 Score = 29.6 bits (65), Expect = 9.6
 Identities = 54/308 (17%), Positives = 118/308 (38%), Gaps = 42/308 (13%)

Query: 239  EIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLR-------QIYVK 291
            ++ R ++E     DEL  T ER+++ +  L   + K  +   E + L+       ++Y +
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 292  QQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKS 351
             +     L    +  +E++   ++++EE +  D  + +     +     +D++ +  ++ 
Sbjct: 906  AEEMRVRLAAKKQELEEILHEMEARLEEEE--DRGQQLQAERKKMAQQMLDLEEQLEEEE 963

Query: 352  LFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVI-TLSSIFTKDLVEKHNLP 410
              + QK +   V      K   DE      Q + +  E+ ++    S  T +L E+    
Sbjct: 964  AAR-QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022

Query: 411  WSLGGKTQIEPENKITLCKIHTKSPKCHGTGVQNEGKQPSETPTL-----SDEKQWHDVS 465
             +L   T+++ +++  + ++  +        ++ E K   E   L      D   +H+  
Sbjct: 1023 KNL---TKLKNKHESMISELEVR--------LKKEEKSRQELEKLKRKLEGDASDFHEQI 1071

Query: 466  VYLGLTNCPSSKHPEKLDVECQDQMERSEISCCQKNEACLGESGMCDSKCCHPSNFIIEA 525
              L            K + E Q  + R +    QKN A                  I E 
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL---------------KKIREL 1116

Query: 526  PGHMSDVE 533
             GH+SD++
Sbjct: 1117 EGHISDLQ 1124


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 96/429 (22%), Positives = 176/429 (41%), Gaps = 46/429 (10%)

Query: 11   RQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEE 70
            +Q +  E ++   E  R++LQL     + + K+L D + V   Q     ++R+    LEE
Sbjct: 957  QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK---LLEE 1013

Query: 71   RCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSED 130
            R S L   L +  E  ++LTK     ES   E +  L+K +   QE+ +       L   
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRK 1066

Query: 131  LEARNETLSNTLVELSAQVG----QLQAREQALTTMIKLKDKDIIE---AVNHIADCSGK 183
            LE         + +L AQ+     QL  +E+ L   +   D +I +   A+  I +  G 
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1126

Query: 184  FKMLEHALRDAKMAETCIVKEKQDYKQKLKALKI---------------------EVNKL 222
               L+  L   + A     K+K+D  ++L+ALK                      EV  L
Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1186

Query: 223  KEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSEL 282
            K+ L+E+T  +  Q +E   ++Q+ +   +EL   +E+ KR    L+  K   E+ N++L
Sbjct: 1187 KKALDEETRSHEAQVQE---MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243

Query: 283  HNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVD 342
                ++  + + +++     +E     +Q   SK  + +   +  +  +  L+N    V 
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQ---VQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300

Query: 343  IKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFG--EKSVITLSSIFT 400
                + +    K  K  A L  Q +  +    E   +K  + T     E+   +L     
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1360

Query: 401  KDLVEKHNL 409
            +++  K NL
Sbjct: 1361 EEMEAKQNL 1369



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 94/432 (21%), Positives = 184/432 (42%), Gaps = 71/432 (16%)

Query: 8    LAGRQNIGSE-------VEISTIEKQRKELQLLIG-----ELKDRDKELNDMVAVHQQQL 55
            LA  +NI S+        E    EK+ K L L        E K+  +  N M+    + L
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523

Query: 56   LSWEEDRQK-VLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQL 114
            +S ++D  K V  LE+    LE ++ +    +  L  +++A E  ++  +  +Q  + Q 
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583

Query: 115  QEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQA------REQALTTMIK---- 164
            +              DL+AR+E       +L  Q+ + +       +++AL    K    
Sbjct: 1584 ER-------------DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630

Query: 165  --LKDKDII---------EAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLK 213
              LKD ++          EA+  +     + K  +  L DA+ +   I    ++ ++K K
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690

Query: 214  ALKIEVNKLKEDL-------NEKTTENNEQREEIIRLKQEKSCLHDE----------LLF 256
            +L+ ++ +L+EDL        +   E  E  EE+      ++ L DE          L  
Sbjct: 1691 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750

Query: 257  TVEREKRKDELLN--IAKSKQ--ERTNSELHNLRQIYVKQQSDLQFL-NFNVENSQELIQ 311
             +E E+   E ++  + K+ Q  E+ ++EL   R    K +S  Q L   N E   +L +
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810

Query: 312  MYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSL-FKDQKFEAMLVQQNRSDK 370
            M  +   + K+  ++ +  ++ LE    +   +++   KSL  KD+K + +L+Q    ++
Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV-EDER 1869

Query: 371  SSCDECKEKKQQ 382
               ++ KE+ ++
Sbjct: 1870 KMAEQYKEQAEK 1881



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 72/360 (20%), Positives = 147/360 (40%), Gaps = 43/360 (11%)

Query: 36   ELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKA 95
            E++ ++ EL       Q+     +E  QK   L E  + L+ +L   TE+          
Sbjct: 860  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY--------- 910

Query: 96   LESNQMECQTALQKTQLQ--LQEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQ 153
             E+ +M  + A +K +L+  L EM  +        + L+A  + ++  +++L  Q+ + +
Sbjct: 911  AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970

Query: 154  AREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLK 213
            A  Q L           +E V        K K LE  +         + KE++  ++++ 
Sbjct: 971  AARQKLQ----------LEKVT----AEAKIKKLEDEILVMDDQNNKLSKERKLLEERI- 1015

Query: 214  ALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKS 273
                       DL     E  E+ + + +LK +   +  EL   +++E++  + L   K 
Sbjct: 1016 ----------SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065

Query: 274  KQERTNSELHNLRQIYVKQQSDL--QFLNFNVENSQELIQMYDSKMEESKALDSSRDM-- 329
            K E   S+ H        Q ++L  Q      E    L ++ D   +++ AL   R++  
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125

Query: 330  CLSDLE---NNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTV 386
             +SDL+   ++      K EK ++ L ++ +     ++      ++  E + K++Q  TV
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 80/391 (20%), Positives = 166/391 (42%), Gaps = 53/391 (13%)

Query: 22   TIEKQRKELQ---LLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLT-LEERCSKLEG 77
            T+EK+  +L     ++G+ K   +     +    Q+L S   D ++    L ++  KL+ 
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294

Query: 78   ELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNET 137
            E+   T ++     K   L  +     + LQ TQ  LQE  ++  + S     LE    +
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1354

Query: 138  LSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMA 197
            L + L E      +++A+ Q L   I   +  + ++   + D +   + LE      K  
Sbjct: 1355 LQDQLDE------EMEAK-QNLERHISTLNIQLSDSKKKLQDFASTVEALEEG---KKRF 1404

Query: 198  ETCIVKEKQDYKQKLKA---LKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDEL 254
            +  I    Q Y++K  A   L+   N+L+++L++   + + QR+ +  L ++K    D+L
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL-EKKQRKFDQL 1463

Query: 255  L---------FTVEREK-------RKDELLNIAKSKQE--RTNSELHNLRQIYVKQQSDL 296
            L         +  ER++       ++ + L++A++ +E      EL    ++   +  DL
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523

Query: 297  ----QFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSL 352
                  +  NV   ++  +  +++MEE K         L +LE      D  +      L
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQ-------LEELE------DELQATEDAKL 1570

Query: 353  FKDQKFEAMLVQQNRSDKSSCDECKEKKQQI 383
              +   +A+  Q  R  ++  ++ +EK++Q+
Sbjct: 1571 RLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 78/441 (17%), Positives = 184/441 (41%), Gaps = 36/441 (8%)

Query: 18   VEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEG 77
            +++S  +K+ ++    +  L++  K     +    QQ   +EE       LE+  ++L+ 
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ---YEEKAAAYDKLEKTKNRLQQ 1434

Query: 78   ELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNET 137
            EL      + +  + V  LE  Q +    L + +    + A +   +   + + E +  +
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494

Query: 138  LSNTLVELSAQVGQLQAREQALTT--MIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAK 195
            L+  L E       L+A+E+   T  M+K + +D++ + + +     + +  + AL    
Sbjct: 1495 LARALEEA------LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548

Query: 196  MAETCIVKEKQDYKQKLK--ALKIEVN------KLKEDLNEKTTENNEQREEIIR-LKQE 246
                  ++E +D  Q  +   L++EVN      + + DL  +  +N E+R ++ R L + 
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608

Query: 247  KSCLHDE----LLFTVEREKRKDELLNI---AKSKQERTNSELHNLRQIYVKQQSDLQFL 299
            ++ L DE     L    ++K + +L ++   A S  +     +  LR++  + +   + L
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668

Query: 300  NFNVENSQELIQMYDSKMEESKALDSSRDMCLSDL---ENNHPKVDIKREKNQKSLFKDQ 356
                 +  E+        +++K+L++       DL   E    + D+++E+  + L    
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728

Query: 357  KFEAMLVQQNRSDKSSC----DECKEKKQQIDTVFG--EKSVITLSSIFTKDLVEKHNLP 410
                 L  + R  ++      +E +E++  ++ +     K+      +  +   E+    
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788

Query: 411  WSLGGKTQIEPENKITLCKIH 431
             +   + Q+E +NK    K+H
Sbjct: 1789 KNESARQQLERQNKELRSKLH 1809



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 85/440 (19%), Positives = 179/440 (40%), Gaps = 71/440 (16%)

Query: 17   EVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLS----WEEDRQKVLTLEERC 72
            E E+   ++++++ +  + EL+ +  +L +   + Q+QL +    + E  +  + L  + 
Sbjct: 865  EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 924

Query: 73   SKLEGELHK----------RTEIIRSLTKKVKA----LESNQMECQTALQKTQLQ---LQ 115
             +LE  LH+          R + +++  KK+      LE    E + A QK QL+    +
Sbjct: 925  QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 984

Query: 116  EMAQKATHSSLLSED-----------LEARNETLSNTLVE------------------LS 146
               +K     L+ +D           LE R   L+  L E                  +S
Sbjct: 985  AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044

Query: 147  AQVGQLQAREQALTTMIKLKDK---DIIEAVNHIADCSGKFKML-------EHALRDAKM 196
                +L+  E++   + KLK K   D  +    IAD   +   L       E  L+ A  
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1104

Query: 197  AETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLF 256
                 + +K +  +K++ L+  ++ L+EDL+ +    N+  ++   L +E   L  EL  
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164

Query: 257  TVE--------REKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQE 308
            T++        R KR+ E+  + K+  E T S    ++++  K    ++ L   +E  + 
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224

Query: 309  LIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRS 368
                 D   +  +  ++     L  L     +V+ K++K +  +   Q+ ++      R+
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV---QELQSKCSDGERA 1281

Query: 369  DKSSCDECKEKKQQIDTVFG 388
                 D+  + + ++++V G
Sbjct: 1282 RAELNDKVHKLQNEVESVTG 1301



 Score = 33.1 bits (74), Expect = 0.87
 Identities = 37/194 (19%), Positives = 84/194 (43%), Gaps = 9/194 (4%)

Query: 209  KQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELL 268
            +++++A + E+ K KE   +   E  E  ++  +L +EK+ L ++L    E     +E+ 
Sbjct: 858  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917

Query: 269  NIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRD 328
                +K++     LH +     +++   Q L    +   + +   + ++EE +A      
Sbjct: 918  VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK-- 975

Query: 329  MCLSDLENNHPKVDIKREKNQKSLFKDQ----KFEAMLVQQNRSDKSSCDECKEKKQQID 384
                 LE    +  IK+ +++  +  DQ      E  L+++  SD ++    +E+K +  
Sbjct: 976  ---LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032

Query: 385  TVFGEKSVITLSSI 398
            T    K    +S +
Sbjct: 1033 TKLKNKHESMISEL 1046



 Score = 29.6 bits (65), Expect = 9.6
 Identities = 54/308 (17%), Positives = 118/308 (38%), Gaps = 42/308 (13%)

Query: 239  EIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLR-------QIYVK 291
            ++ R ++E     DEL  T ER+++ +  L   + K  +   E + L+       ++Y +
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 292  QQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKS 351
             +     L    +  +E++   ++++EE +  D  + +     +     +D++ +  ++ 
Sbjct: 913  AEEMRVRLAAKKQELEEILHEMEARLEEEE--DRGQQLQAERKKMAQQMLDLEEQLEEEE 970

Query: 352  LFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVI-TLSSIFTKDLVEKHNLP 410
              + QK +   V      K   DE      Q + +  E+ ++    S  T +L E+    
Sbjct: 971  AAR-QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029

Query: 411  WSLGGKTQIEPENKITLCKIHTKSPKCHGTGVQNEGKQPSETPTL-----SDEKQWHDVS 465
             +L   T+++ +++  + ++  +        ++ E K   E   L      D   +H+  
Sbjct: 1030 KNL---TKLKNKHESMISELEVR--------LKKEEKSRQELEKLKRKLEGDASDFHEQI 1078

Query: 466  VYLGLTNCPSSKHPEKLDVECQDQMERSEISCCQKNEACLGESGMCDSKCCHPSNFIIEA 525
              L            K + E Q  + R +    QKN A                  I E 
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL---------------KKIREL 1123

Query: 526  PGHMSDVE 533
             GH+SD++
Sbjct: 1124 EGHISDLQ 1131


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 96/429 (22%), Positives = 176/429 (41%), Gaps = 46/429 (10%)

Query: 11   RQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEE 70
            +Q +  E ++   E  R++LQL     + + K+L D + V   Q     ++R+    LEE
Sbjct: 957  QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK---LLEE 1013

Query: 71   RCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSED 130
            R S L   L +  E  ++LTK     ES   E +  L+K +   QE+ +       L   
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRK 1066

Query: 131  LEARNETLSNTLVELSAQVG----QLQAREQALTTMIKLKDKDIIE---AVNHIADCSGK 183
            LE         + +L AQ+     QL  +E+ L   +   D +I +   A+  I +  G 
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1126

Query: 184  FKMLEHALRDAKMAETCIVKEKQDYKQKLKALKI---------------------EVNKL 222
               L+  L   + A     K+K+D  ++L+ALK                      EV  L
Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1186

Query: 223  KEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSEL 282
            K+ L+E+T  +  Q +E   ++Q+ +   +EL   +E+ KR    L+  K   E+ N++L
Sbjct: 1187 KKALDEETRSHEAQVQE---MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243

Query: 283  HNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVD 342
                ++  + + +++     +E     +Q   SK  + +   +  +  +  L+N    V 
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQ---VQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300

Query: 343  IKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFG--EKSVITLSSIFT 400
                + +    K  K  A L  Q +  +    E   +K  + T     E+   +L     
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1360

Query: 401  KDLVEKHNL 409
            +++  K NL
Sbjct: 1361 EEMEAKQNL 1369



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 94/432 (21%), Positives = 184/432 (42%), Gaps = 71/432 (16%)

Query: 8    LAGRQNIGSE-------VEISTIEKQRKELQLLIG-----ELKDRDKELNDMVAVHQQQL 55
            LA  +NI S+        E    EK+ K L L        E K+  +  N M+    + L
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523

Query: 56   LSWEEDRQK-VLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQL 114
            +S ++D  K V  LE+    LE ++ +    +  L  +++A E  ++  +  +Q  + Q 
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583

Query: 115  QEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQA------REQALTTMIK---- 164
            +              DL+AR+E       +L  Q+ + +       +++AL    K    
Sbjct: 1584 ER-------------DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630

Query: 165  --LKDKDII---------EAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLK 213
              LKD ++          EA+  +     + K  +  L DA+ +   I    ++ ++K K
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690

Query: 214  ALKIEVNKLKEDL-------NEKTTENNEQREEIIRLKQEKSCLHDE----------LLF 256
            +L+ ++ +L+EDL        +   E  E  EE+      ++ L DE          L  
Sbjct: 1691 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750

Query: 257  TVEREKRKDELLN--IAKSKQ--ERTNSELHNLRQIYVKQQSDLQFL-NFNVENSQELIQ 311
             +E E+   E ++  + K+ Q  E+ ++EL   R    K +S  Q L   N E   +L +
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810

Query: 312  MYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSL-FKDQKFEAMLVQQNRSDK 370
            M  +   + K+  ++ +  ++ LE    +   +++   KSL  KD+K + +L+Q    ++
Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV-EDER 1869

Query: 371  SSCDECKEKKQQ 382
               ++ KE+ ++
Sbjct: 1870 KMAEQYKEQAEK 1881



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 72/360 (20%), Positives = 147/360 (40%), Gaps = 43/360 (11%)

Query: 36   ELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKA 95
            E++ ++ EL       Q+     +E  QK   L E  + L+ +L   TE+          
Sbjct: 860  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY--------- 910

Query: 96   LESNQMECQTALQKTQLQ--LQEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQ 153
             E+ +M  + A +K +L+  L EM  +        + L+A  + ++  +++L  Q+ + +
Sbjct: 911  AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970

Query: 154  AREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLK 213
            A  Q L           +E V        K K LE  +         + KE++  ++++ 
Sbjct: 971  AARQKLQ----------LEKVT----AEAKIKKLEDEILVMDDQNNKLSKERKLLEERI- 1015

Query: 214  ALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKS 273
                       DL     E  E+ + + +LK +   +  EL   +++E++  + L   K 
Sbjct: 1016 ----------SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065

Query: 274  KQERTNSELHNLRQIYVKQQSDL--QFLNFNVENSQELIQMYDSKMEESKALDSSRDM-- 329
            K E   S+ H        Q ++L  Q      E    L ++ D   +++ AL   R++  
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125

Query: 330  CLSDLE---NNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTV 386
             +SDL+   ++      K EK ++ L ++ +     ++      ++  E + K++Q  TV
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 80/391 (20%), Positives = 166/391 (42%), Gaps = 53/391 (13%)

Query: 22   TIEKQRKELQ---LLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLT-LEERCSKLEG 77
            T+EK+  +L     ++G+ K   +     +    Q+L S   D ++    L ++  KL+ 
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294

Query: 78   ELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNET 137
            E+   T ++     K   L  +     + LQ TQ  LQE  ++  + S     LE    +
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1354

Query: 138  LSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMA 197
            L + L E      +++A+ Q L   I   +  + ++   + D +   + LE      K  
Sbjct: 1355 LQDQLDE------EMEAK-QNLERHISTLNIQLSDSKKKLQDFASTVEALEEG---KKRF 1404

Query: 198  ETCIVKEKQDYKQKLKA---LKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDEL 254
            +  I    Q Y++K  A   L+   N+L+++L++   + + QR+ +  L ++K    D+L
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL-EKKQRKFDQL 1463

Query: 255  L---------FTVEREK-------RKDELLNIAKSKQE--RTNSELHNLRQIYVKQQSDL 296
            L         +  ER++       ++ + L++A++ +E      EL    ++   +  DL
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523

Query: 297  ----QFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSL 352
                  +  NV   ++  +  +++MEE K         L +LE      D  +      L
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQ-------LEELE------DELQATEDAKL 1570

Query: 353  FKDQKFEAMLVQQNRSDKSSCDECKEKKQQI 383
              +   +A+  Q  R  ++  ++ +EK++Q+
Sbjct: 1571 RLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 78/441 (17%), Positives = 184/441 (41%), Gaps = 36/441 (8%)

Query: 18   VEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEG 77
            +++S  +K+ ++    +  L++  K     +    QQ   +EE       LE+  ++L+ 
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ---YEEKAAAYDKLEKTKNRLQQ 1434

Query: 78   ELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNET 137
            EL      + +  + V  LE  Q +    L + +    + A +   +   + + E +  +
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494

Query: 138  LSNTLVELSAQVGQLQAREQALTT--MIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAK 195
            L+  L E       L+A+E+   T  M+K + +D++ + + +     + +  + AL    
Sbjct: 1495 LARALEEA------LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548

Query: 196  MAETCIVKEKQDYKQKLK--ALKIEVN------KLKEDLNEKTTENNEQREEIIR-LKQE 246
                  ++E +D  Q  +   L++EVN      + + DL  +  +N E+R ++ R L + 
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608

Query: 247  KSCLHDE----LLFTVEREKRKDELLNI---AKSKQERTNSELHNLRQIYVKQQSDLQFL 299
            ++ L DE     L    ++K + +L ++   A S  +     +  LR++  + +   + L
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668

Query: 300  NFNVENSQELIQMYDSKMEESKALDSSRDMCLSDL---ENNHPKVDIKREKNQKSLFKDQ 356
                 +  E+        +++K+L++       DL   E    + D+++E+  + L    
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728

Query: 357  KFEAMLVQQNRSDKSSC----DECKEKKQQIDTVFG--EKSVITLSSIFTKDLVEKHNLP 410
                 L  + R  ++      +E +E++  ++ +     K+      +  +   E+    
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788

Query: 411  WSLGGKTQIEPENKITLCKIH 431
             +   + Q+E +NK    K+H
Sbjct: 1789 KNESARQQLERQNKELRSKLH 1809



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 85/440 (19%), Positives = 179/440 (40%), Gaps = 71/440 (16%)

Query: 17   EVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLS----WEEDRQKVLTLEERC 72
            E E+   ++++++ +  + EL+ +  +L +   + Q+QL +    + E  +  + L  + 
Sbjct: 865  EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 924

Query: 73   SKLEGELHK----------RTEIIRSLTKKVKA----LESNQMECQTALQKTQLQ---LQ 115
             +LE  LH+          R + +++  KK+      LE    E + A QK QL+    +
Sbjct: 925  QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 984

Query: 116  EMAQKATHSSLLSED-----------LEARNETLSNTLVE------------------LS 146
               +K     L+ +D           LE R   L+  L E                  +S
Sbjct: 985  AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044

Query: 147  AQVGQLQAREQALTTMIKLKDK---DIIEAVNHIADCSGKFKML-------EHALRDAKM 196
                +L+  E++   + KLK K   D  +    IAD   +   L       E  L+ A  
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1104

Query: 197  AETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLF 256
                 + +K +  +K++ L+  ++ L+EDL+ +    N+  ++   L +E   L  EL  
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164

Query: 257  TVE--------REKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQE 308
            T++        R KR+ E+  + K+  E T S    ++++  K    ++ L   +E  + 
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224

Query: 309  LIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRS 368
                 D   +  +  ++     L  L     +V+ K++K +  +   Q+ ++      R+
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV---QELQSKCSDGERA 1281

Query: 369  DKSSCDECKEKKQQIDTVFG 388
                 D+  + + ++++V G
Sbjct: 1282 RAELNDKVHKLQNEVESVTG 1301



 Score = 33.1 bits (74), Expect = 0.87
 Identities = 37/194 (19%), Positives = 84/194 (43%), Gaps = 9/194 (4%)

Query: 209  KQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELL 268
            +++++A + E+ K KE   +   E  E  ++  +L +EK+ L ++L    E     +E+ 
Sbjct: 858  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917

Query: 269  NIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRD 328
                +K++     LH +     +++   Q L    +   + +   + ++EE +A      
Sbjct: 918  VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK-- 975

Query: 329  MCLSDLENNHPKVDIKREKNQKSLFKDQ----KFEAMLVQQNRSDKSSCDECKEKKQQID 384
                 LE    +  IK+ +++  +  DQ      E  L+++  SD ++    +E+K +  
Sbjct: 976  ---LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032

Query: 385  TVFGEKSVITLSSI 398
            T    K    +S +
Sbjct: 1033 TKLKNKHESMISEL 1046



 Score = 29.6 bits (65), Expect = 9.6
 Identities = 54/308 (17%), Positives = 118/308 (38%), Gaps = 42/308 (13%)

Query: 239  EIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLR-------QIYVK 291
            ++ R ++E     DEL  T ER+++ +  L   + K  +   E + L+       ++Y +
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 292  QQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKS 351
             +     L    +  +E++   ++++EE +  D  + +     +     +D++ +  ++ 
Sbjct: 913  AEEMRVRLAAKKQELEEILHEMEARLEEEE--DRGQQLQAERKKMAQQMLDLEEQLEEEE 970

Query: 352  LFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVI-TLSSIFTKDLVEKHNLP 410
              + QK +   V      K   DE      Q + +  E+ ++    S  T +L E+    
Sbjct: 971  AAR-QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029

Query: 411  WSLGGKTQIEPENKITLCKIHTKSPKCHGTGVQNEGKQPSETPTL-----SDEKQWHDVS 465
             +L   T+++ +++  + ++  +        ++ E K   E   L      D   +H+  
Sbjct: 1030 KNL---TKLKNKHESMISELEVR--------LKKEEKSRQELEKLKRKLEGDASDFHEQI 1078

Query: 466  VYLGLTNCPSSKHPEKLDVECQDQMERSEISCCQKNEACLGESGMCDSKCCHPSNFIIEA 525
              L            K + E Q  + R +    QKN A                  I E 
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL---------------KKIREL 1123

Query: 526  PGHMSDVE 533
             GH+SD++
Sbjct: 1124 EGHISDLQ 1131


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 96/429 (22%), Positives = 176/429 (41%), Gaps = 46/429 (10%)

Query: 11   RQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEE 70
            +Q +  E ++   E  R++LQL     + + K+L D + V   Q     ++R+    LEE
Sbjct: 950  QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK---LLEE 1006

Query: 71   RCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSED 130
            R S L   L +  E  ++LTK     ES   E +  L+K +   QE+ +       L   
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRK 1059

Query: 131  LEARNETLSNTLVELSAQVG----QLQAREQALTTMIKLKDKDIIE---AVNHIADCSGK 183
            LE         + +L AQ+     QL  +E+ L   +   D +I +   A+  I +  G 
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1119

Query: 184  FKMLEHALRDAKMAETCIVKEKQDYKQKLKALKI---------------------EVNKL 222
               L+  L   + A     K+K+D  ++L+ALK                      EV  L
Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1179

Query: 223  KEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSEL 282
            K+ L+E+T  +  Q +E   ++Q+ +   +EL   +E+ KR    L+  K   E+ N++L
Sbjct: 1180 KKALDEETRSHEAQVQE---MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236

Query: 283  HNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVD 342
                ++  + + +++     +E     +Q   SK  + +   +  +  +  L+N    V 
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKLEAQ---VQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293

Query: 343  IKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFG--EKSVITLSSIFT 400
                + +    K  K  A L  Q +  +    E   +K  + T     E+   +L     
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1353

Query: 401  KDLVEKHNL 409
            +++  K NL
Sbjct: 1354 EEMEAKQNL 1362



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 94/432 (21%), Positives = 184/432 (42%), Gaps = 71/432 (16%)

Query: 8    LAGRQNIGSE-------VEISTIEKQRKELQLLIG-----ELKDRDKELNDMVAVHQQQL 55
            LA  +NI S+        E    EK+ K L L        E K+  +  N M+    + L
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516

Query: 56   LSWEEDRQK-VLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQL 114
            +S ++D  K V  LE+    LE ++ +    +  L  +++A E  ++  +  +Q  + Q 
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576

Query: 115  QEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQA------REQALTTMIK---- 164
            +              DL+AR+E       +L  Q+ + +       +++AL    K    
Sbjct: 1577 ER-------------DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623

Query: 165  --LKDKDII---------EAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLK 213
              LKD ++          EA+  +     + K  +  L DA+ +   I    ++ ++K K
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683

Query: 214  ALKIEVNKLKEDL-------NEKTTENNEQREEIIRLKQEKSCLHDE----------LLF 256
            +L+ ++ +L+EDL        +   E  E  EE+      ++ L DE          L  
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1743

Query: 257  TVEREKRKDELLN--IAKSKQ--ERTNSELHNLRQIYVKQQSDLQFL-NFNVENSQELIQ 311
             +E E+   E ++  + K+ Q  E+ ++EL   R    K +S  Q L   N E   +L +
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803

Query: 312  MYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSL-FKDQKFEAMLVQQNRSDK 370
            M  +   + K+  ++ +  ++ LE    +   +++   KSL  KD+K + +L+Q    ++
Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV-EDER 1862

Query: 371  SSCDECKEKKQQ 382
               ++ KE+ ++
Sbjct: 1863 KMAEQYKEQAEK 1874



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 72/360 (20%), Positives = 147/360 (40%), Gaps = 43/360 (11%)

Query: 36   ELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKA 95
            E++ ++ EL       Q+     +E  QK   L E  + L+ +L   TE+          
Sbjct: 853  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY--------- 903

Query: 96   LESNQMECQTALQKTQLQ--LQEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQ 153
             E+ +M  + A +K +L+  L EM  +        + L+A  + ++  +++L  Q+ + +
Sbjct: 904  AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963

Query: 154  AREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLK 213
            A  Q L           +E V        K K LE  +         + KE++  ++++ 
Sbjct: 964  AARQKLQ----------LEKVT----AEAKIKKLEDEILVMDDQNNKLSKERKLLEERI- 1008

Query: 214  ALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKS 273
                       DL     E  E+ + + +LK +   +  EL   +++E++  + L   K 
Sbjct: 1009 ----------SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058

Query: 274  KQERTNSELHNLRQIYVKQQSDL--QFLNFNVENSQELIQMYDSKMEESKALDSSRDM-- 329
            K E   S+ H        Q ++L  Q      E    L ++ D   +++ AL   R++  
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118

Query: 330  CLSDLE---NNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTV 386
             +SDL+   ++      K EK ++ L ++ +     ++      ++  E + K++Q  TV
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 80/391 (20%), Positives = 166/391 (42%), Gaps = 53/391 (13%)

Query: 22   TIEKQRKELQ---LLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLT-LEERCSKLEG 77
            T+EK+  +L     ++G+ K   +     +    Q+L S   D ++    L ++  KL+ 
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287

Query: 78   ELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNET 137
            E+   T ++     K   L  +     + LQ TQ  LQE  ++  + S     LE    +
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1347

Query: 138  LSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMA 197
            L + L E      +++A+ Q L   I   +  + ++   + D +   + LE      K  
Sbjct: 1348 LQDQLDE------EMEAK-QNLERHISTLNIQLSDSKKKLQDFASTVEALEEG---KKRF 1397

Query: 198  ETCIVKEKQDYKQKLKA---LKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDEL 254
            +  I    Q Y++K  A   L+   N+L+++L++   + + QR+ +  L ++K    D+L
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL-EKKQRKFDQL 1456

Query: 255  L---------FTVEREK-------RKDELLNIAKSKQE--RTNSELHNLRQIYVKQQSDL 296
            L         +  ER++       ++ + L++A++ +E      EL    ++   +  DL
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516

Query: 297  ----QFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSL 352
                  +  NV   ++  +  +++MEE K         L +LE      D  +      L
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQ-------LEELE------DELQATEDAKL 1563

Query: 353  FKDQKFEAMLVQQNRSDKSSCDECKEKKQQI 383
              +   +A+  Q  R  ++  ++ +EK++Q+
Sbjct: 1564 RLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 78/441 (17%), Positives = 184/441 (41%), Gaps = 36/441 (8%)

Query: 18   VEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEG 77
            +++S  +K+ ++    +  L++  K     +    QQ   +EE       LE+  ++L+ 
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ---YEEKAAAYDKLEKTKNRLQQ 1427

Query: 78   ELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNET 137
            EL      + +  + V  LE  Q +    L + +    + A +   +   + + E +  +
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487

Query: 138  LSNTLVELSAQVGQLQAREQALTT--MIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAK 195
            L+  L E       L+A+E+   T  M+K + +D++ + + +     + +  + AL    
Sbjct: 1488 LARALEEA------LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541

Query: 196  MAETCIVKEKQDYKQKLK--ALKIEVN------KLKEDLNEKTTENNEQREEIIR-LKQE 246
                  ++E +D  Q  +   L++EVN      + + DL  +  +N E+R ++ R L + 
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601

Query: 247  KSCLHDE----LLFTVEREKRKDELLNI---AKSKQERTNSELHNLRQIYVKQQSDLQFL 299
            ++ L DE     L    ++K + +L ++   A S  +     +  LR++  + +   + L
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661

Query: 300  NFNVENSQELIQMYDSKMEESKALDSSRDMCLSDL---ENNHPKVDIKREKNQKSLFKDQ 356
                 +  E+        +++K+L++       DL   E    + D+++E+  + L    
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721

Query: 357  KFEAMLVQQNRSDKSSC----DECKEKKQQIDTVFG--EKSVITLSSIFTKDLVEKHNLP 410
                 L  + R  ++      +E +E++  ++ +     K+      +  +   E+    
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781

Query: 411  WSLGGKTQIEPENKITLCKIH 431
             +   + Q+E +NK    K+H
Sbjct: 1782 KNESARQQLERQNKELRSKLH 1802



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 85/440 (19%), Positives = 179/440 (40%), Gaps = 71/440 (16%)

Query: 17   EVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLS----WEEDRQKVLTLEERC 72
            E E+   ++++++ +  + EL+ +  +L +   + Q+QL +    + E  +  + L  + 
Sbjct: 858  EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 917

Query: 73   SKLEGELHK----------RTEIIRSLTKKVKA----LESNQMECQTALQKTQLQ---LQ 115
             +LE  LH+          R + +++  KK+      LE    E + A QK QL+    +
Sbjct: 918  QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 977

Query: 116  EMAQKATHSSLLSED-----------LEARNETLSNTLVE------------------LS 146
               +K     L+ +D           LE R   L+  L E                  +S
Sbjct: 978  AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037

Query: 147  AQVGQLQAREQALTTMIKLKDK---DIIEAVNHIADCSGKFKML-------EHALRDAKM 196
                +L+  E++   + KLK K   D  +    IAD   +   L       E  L+ A  
Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1097

Query: 197  AETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLF 256
                 + +K +  +K++ L+  ++ L+EDL+ +    N+  ++   L +E   L  EL  
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157

Query: 257  TVE--------REKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQE 308
            T++        R KR+ E+  + K+  E T S    ++++  K    ++ L   +E  + 
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217

Query: 309  LIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRS 368
                 D   +  +  ++     L  L     +V+ K++K +  +   Q+ ++      R+
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV---QELQSKCSDGERA 1274

Query: 369  DKSSCDECKEKKQQIDTVFG 388
                 D+  + + ++++V G
Sbjct: 1275 RAELNDKVHKLQNEVESVTG 1294



 Score = 33.1 bits (74), Expect = 0.87
 Identities = 37/194 (19%), Positives = 84/194 (43%), Gaps = 9/194 (4%)

Query: 209  KQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELL 268
            +++++A + E+ K KE   +   E  E  ++  +L +EK+ L ++L    E     +E+ 
Sbjct: 851  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910

Query: 269  NIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRD 328
                +K++     LH +     +++   Q L    +   + +   + ++EE +A      
Sbjct: 911  VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK-- 968

Query: 329  MCLSDLENNHPKVDIKREKNQKSLFKDQ----KFEAMLVQQNRSDKSSCDECKEKKQQID 384
                 LE    +  IK+ +++  +  DQ      E  L+++  SD ++    +E+K +  
Sbjct: 969  ---LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025

Query: 385  TVFGEKSVITLSSI 398
            T    K    +S +
Sbjct: 1026 TKLKNKHESMISEL 1039



 Score = 29.6 bits (65), Expect = 9.6
 Identities = 54/308 (17%), Positives = 118/308 (38%), Gaps = 42/308 (13%)

Query: 239  EIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLR-------QIYVK 291
            ++ R ++E     DEL  T ER+++ +  L   + K  +   E + L+       ++Y +
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 292  QQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKS 351
             +     L    +  +E++   ++++EE +  D  + +     +     +D++ +  ++ 
Sbjct: 906  AEEMRVRLAAKKQELEEILHEMEARLEEEE--DRGQQLQAERKKMAQQMLDLEEQLEEEE 963

Query: 352  LFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVI-TLSSIFTKDLVEKHNLP 410
              + QK +   V      K   DE      Q + +  E+ ++    S  T +L E+    
Sbjct: 964  AAR-QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022

Query: 411  WSLGGKTQIEPENKITLCKIHTKSPKCHGTGVQNEGKQPSETPTL-----SDEKQWHDVS 465
             +L   T+++ +++  + ++  +        ++ E K   E   L      D   +H+  
Sbjct: 1023 KNL---TKLKNKHESMISELEVR--------LKKEEKSRQELEKLKRKLEGDASDFHEQI 1071

Query: 466  VYLGLTNCPSSKHPEKLDVECQDQMERSEISCCQKNEACLGESGMCDSKCCHPSNFIIEA 525
              L            K + E Q  + R +    QKN A                  I E 
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL---------------KKIREL 1116

Query: 526  PGHMSDVE 533
             GH+SD++
Sbjct: 1117 EGHISDLQ 1124


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 96/449 (21%), Positives = 201/449 (44%), Gaps = 48/449 (10%)

Query: 1    MNPPAAFLAGRQNIGSEVEIS--TIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSW 58
            ++  AA  A R ++ + ++ +   ++ +++EL  +  +L     +L D      Q     
Sbjct: 652  LSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHL 711

Query: 59   EEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMA 118
            +E ++K L+LE++  +LEG+              +K LE++ +E + + ++    LQ+  
Sbjct: 712  KEYKEKYLSLEQKTEELEGQ--------------IKKLEADSLEVKASKEQALQDLQQQR 757

Query: 119  QKATHSSL----LSEDLEARNETLSNTLVELSAQVGQLQAREQALT-----TMIKLKDKD 169
            Q  T   L    LS+ LE   E +S+T ++L  +   L++ +Q LT       I  +D +
Sbjct: 758  QLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFE 817

Query: 170  IIEAVNHI--ADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLN 227
             +     I   + + + +     L+  KM +  ++ E    K KL  +    + LK   +
Sbjct: 818  TLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS---DSLKNSKS 874

Query: 228  EKTTENNEQREEIIRL----KQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELH 283
            E   EN + +  I+ L    K+ K  L  ++  T++ +K   + L   K    +   EL+
Sbjct: 875  EFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELN 934

Query: 284  NLRQIYVKQQSDLQFLNFNVE-----NSQELIQMYDSKMEESKALDSSRDMCLSDLENNH 338
            ++++  ++ Q+ L+  N   E     N  EL Q  + K ++ +AL    ++ ++ L+   
Sbjct: 935  SMQEQLIQAQNTLK-QNEKEEQQLQGNINELKQSSEQKKKQIEALQG--ELKIAVLQKTE 991

Query: 339  PKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSI 398
             +  ++++  Q +     + E + V QN  +KS     +  KQ     +G +S +  +  
Sbjct: 992  LENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQ----ETFKQLQSDFYGRESELLATRQ 1047

Query: 399  FTKDLVEKHNLPWS--LGGKTQIEPENKI 425
              K + EK +L     +  + QI  +NK+
Sbjct: 1048 DLKSVEEKLSLAQEDLISNRNQIGNQNKL 1076



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 91/446 (20%), Positives = 196/446 (43%), Gaps = 65/446 (14%)

Query: 23  IEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLE------ 76
           + ++ +  Q L  EL + + +   + A  +Q     EE  Q  L L+   ++L       
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET 426

Query: 77  ----GELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLE 132
               GE H R +  R L+ + K ++  Q      L+ ++L+ +++ +K T+S+ L   L+
Sbjct: 427 ERQLGEAHGRLKEQRQLSSE-KLMDKEQQVADLQLKLSRLE-EQLKEKVTNSTELQHQLD 484

Query: 133 ARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALR 192
              +           Q  + QA +Q+ T  ++    D+ + +  I D   K + LE  L+
Sbjct: 485 KTKQ-----------QHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQ 533

Query: 193 DAKMAETCIVKEKQDYKQKLKALKIE---VNKLKE---DLNEKTTENNEQ-REEIIRLKQ 245
            +K   + + KE++D   K++A + E   +N+L+E    L E+ T+  E+ + +    KQ
Sbjct: 534 KSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQ 593

Query: 246 EKSCLHDELLFTVEREK-----RKDELLNIAKSKQERTNSELHNLRQ------IYVKQQS 294
            +  LHD+    V+ +K      +D +L++  S  E  NS+L+  ++      I +K ++
Sbjct: 594 AQENLHDQ----VQEQKAHLRAAQDRVLSLETSVNE-LNSQLNESKEKVSQLDIQIKAKT 648

Query: 295 DLQF------------LNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKV- 341
           +L              L  +++ +Q  +Q    K +E   + +  D   + L++      
Sbjct: 649 ELLLSAEAAKTAQRADLQNHLDTAQNALQ---DKQQELNKITTQLDQVTAKLQDKQEHCS 705

Query: 342 ---DIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSI 398
                 +E  +K L  +QK E +  Q  + +  S +    K+Q +  +  ++ + T   +
Sbjct: 706 QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 765

Query: 399 FTKDLVEKHNLPWSLGGKTQIEPENK 424
              +L ++  +   +   T+++ + K
Sbjct: 766 RATELSKQLEMEKEIVSSTRLDLQKK 791



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 76/329 (23%), Positives = 149/329 (45%), Gaps = 61/329 (18%)

Query: 17   EVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLE 76
            +V++    K++KEL+  + + K+   +L   +   Q+QL+  +   ++    E+   +L+
Sbjct: 902  QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQN---EKEEQQLQ 958

Query: 77   GELHKRTEIIRSLTKKVKALESNQMECQTA-LQKTQLQ----------LQEMAQKATHSS 125
            G ++   E+ +S  +K K +E+ Q E + A LQKT+L+           QE+A +    S
Sbjct: 959  GNIN---ELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKIS 1015

Query: 126  LLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTM---IKLKDKDIIEAVNHIADCSG 182
            +L  + E   ET      +   +  +L A  Q L ++   + L  +D+I   N I + + 
Sbjct: 1016 VLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNK 1075

Query: 183  KFKML---------EHALRDAKMAETC----------IVKEKQDYKQKLKALKIEVNKLK 223
              + L         + A ++ ++ E C           +KEK+   +K K  +IE  K +
Sbjct: 1076 LIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCR 1135

Query: 224  ED-----LNEKTTENN-EQREEIIRLKQEKSCL----------HDELLFTVEREKRKDEL 267
            ++     LNE+   +  E  +EI  LK  K  L           D L   VE+EKR  ++
Sbjct: 1136 QEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQI 1195

Query: 268  LNIAKSKQERTNSELHNLRQIYVKQQSDL 296
            L      +++   E   L++ ++++++ L
Sbjct: 1196 L------KDQVKKEEEELKKEFIEKEAKL 1218



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 83/453 (18%), Positives = 179/453 (39%), Gaps = 92/453 (20%)

Query: 6    AFLAGRQNIGSEVEISTIEKQRKELQL------LIGELKDRDKELNDMVAVHQQQLLSWE 59
            A L  +Q   S++E    E + K L L      L G++K  + +  ++ A  +Q L   +
Sbjct: 695  AKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQ 754

Query: 60   EDRQKVLTLEERCSKLEGELHKRTEIIRS----LTKKVKALESNQMECQTALQKTQLQLQ 115
            + RQ    LE R ++L  +L    EI+ S    L KK +ALES + +     ++ Q+  Q
Sbjct: 755  QQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQ 814

Query: 116  EMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVN 175
            +          LS++ + ++E L+N +     ++ +++  ++AL T +      + +  +
Sbjct: 815  DF-------ETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSD 867

Query: 176  HIADCSGKFK--------------------------MLEHALRDAKMAETCIVKEK---- 205
             + +   +F+                           +E+ L++ K  +  + KEK    
Sbjct: 868  SLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASH 927

Query: 206  --------------------------------------QDYKQKLKALKIEVNKLKEDLN 227
                                                  Q  +QK K ++    +LK  + 
Sbjct: 928  QLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVL 987

Query: 228  EKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQ 287
            +KT   N+ ++++ +  QE +   +++       ++  E     +S      SEL   RQ
Sbjct: 988  QKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ 1047

Query: 288  IYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREK 347
                 +  L     ++ +++  I   +  ++E K   ++       LE +  K + + ++
Sbjct: 1048 DLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKAT-------LEQDSAKKEQQLQE 1100

Query: 348  NQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKK 380
              K+L   QK +++  ++  ++KS   E +E K
Sbjct: 1101 RCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK 1133



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 79/342 (23%), Positives = 141/342 (41%), Gaps = 77/342 (22%)

Query: 24   EKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKRT 83
            E+++K+++ L GELK    +  ++    QQQL    +  Q++   +E+ S L+    K  
Sbjct: 969  EQKKKQIEALQGELKIAVLQKTELENKLQQQLT---QAAQELAAEKEKISVLQNNYEKSQ 1025

Query: 84   EIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNETLSN--- 140
            E  + L       ES  +  +  L+  + +L          SL  EDL +    + N   
Sbjct: 1026 ETFKQLQSDFYGRESELLATRQDLKSVEEKL----------SLAQEDLISNRNQIGNQNK 1075

Query: 141  ----------TLVELSAQVGQ-LQAREQALTTMIK---LKDKDIIEAVNHIADCSG---- 182
                      TL + SA+  Q LQ R +AL  + K   LK+K+++   + +A+       
Sbjct: 1076 LIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCR 1135

Query: 183  ---KFKMLEHALRDAKM-----------AETCIVKEKQDYKQK---LKA----------- 214
               +   L   L+  K+           A+  ++++K + + K   LKA           
Sbjct: 1136 QEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQI 1195

Query: 215  LKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHD--ELLFTVEREKRKDELLNIAK 272
            LK +V K +E+L ++  E   +    I+ K+     H+  E   T++     + L  + K
Sbjct: 1196 LKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKK 1255

Query: 273  SKQ--ERTNSELHNLRQIYVKQQSDLQ----FLNFNVENSQE 308
              Q  +R  SEL        KQ  DL+     L   V+N+Q+
Sbjct: 1256 EWQSSQRRVSELE-------KQTDDLRGEIAVLEATVQNNQD 1290



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 71/379 (18%), Positives = 146/379 (38%), Gaps = 67/379 (17%)

Query: 16  SEVEISTIEKQRKELQ---LLIGELKDRDKELNDMVAVHQQQLLS-WEEDRQKVLTLEER 71
           S  E+ ++E+Q +E Q     I ++KD  ++    +A     + S ++E+R      E++
Sbjct: 133 SSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQK 192

Query: 72  CSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDL 131
            ++L  EL+K   +I+ L  K + L+   +E    L+K  +Q+Q +    T       + 
Sbjct: 193 VTRLTEELNKEATVIQDL--KTELLQRPGIEDVAVLKKELVQVQTLMDNMTL------ER 244

Query: 132 EARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHAL 191
           E  +E L +   +L +Q    +A    L + +    +++   V                 
Sbjct: 245 ERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQ---------------- 288

Query: 192 RDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLH 251
                                     E+ KLK  +NE T +N    E +++ +Q+ + L 
Sbjct: 289 --------------------------ELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLE 322

Query: 252 DELLFTVEREKRKDELLN----IAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQ 307
           ++       +K     L+      +  Q R ++   +L +I+V+     +      E   
Sbjct: 323 EKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS 382

Query: 308 ELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQ---KSLFKDQKFEAMLVQ 364
           E+   Y     E K L   R+      E     + ++ E NQ   K L  +++      +
Sbjct: 383 EVETKYQHLKAEFKQLQQQRE------EKEQHGLQLQSEINQLHSKLLETERQLGEAHGR 436

Query: 365 QNRSDKSSCDECKEKKQQI 383
                + S ++  +K+QQ+
Sbjct: 437 LKEQRQLSSEKLMDKEQQV 455



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 29/116 (25%), Positives = 58/116 (50%), Gaps = 19/116 (16%)

Query: 20   ISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGEL 79
            + T++K+ +  Q  + EL+ +  +L   +AV +  + + +++R+ +L   ERC K EGE+
Sbjct: 1250 LGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALL---ERCLKGEGEI 1306

Query: 80   HKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARN 135
             K              L++  +E Q  L  T   +QE+ ++  + SL  +  +A N
Sbjct: 1307 EK--------------LQTKVLELQRKLDNTTAAVQELGRE--NQSLQIKHTQALN 1346



 Score = 33.5 bits (75), Expect = 0.67
 Identities = 16/81 (19%), Positives = 44/81 (54%)

Query: 58   WEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEM 117
            W+  +++V  LE++   L GE+      +++   + +AL    ++ +  ++K Q ++ E+
Sbjct: 1257 WQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLEL 1316

Query: 118  AQKATHSSLLSEDLEARNETL 138
             +K  +++   ++L   N++L
Sbjct: 1317 QRKLDNTTAAVQELGRENQSL 1337


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 83/397 (20%), Positives = 173/397 (43%), Gaps = 47/397 (11%)

Query: 11   RQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQL--LSWEEDRQKVLT- 67
            ++   +E ++  + ++   L   I +L    K L +    HQQ L  L  EED+   LT 
Sbjct: 972  KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE---AHQQTLDDLQAEEDKVNTLTK 1028

Query: 68   ----LEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATH 123
                LE++   LEG L +  ++   L +  + LE +    Q ++   + + Q++ +K   
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK 1088

Query: 124  SSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGK 183
                  +L+++ E      ++L  ++ +LQAR + L   I+ +     +A    +D S +
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1148

Query: 184  FKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRL 243
             + +   L +A  A +  ++         K  + E  K++ DL E T + +E     +R 
Sbjct: 1149 LEEISERLEEAGGATSAQIEMN-------KKREAEFQKMRRDLEEATLQ-HEATAATLRK 1200

Query: 244  KQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNV 303
            K   S          E  ++ D L  + K K E+  SE+          + ++  L  NV
Sbjct: 1201 KHADS--------VAELGEQIDNLQRV-KQKLEKEKSEM----------KMEIDDLASNV 1241

Query: 304  E-------NSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQ 356
            E       N +++ +  + ++ E K+ +  +   ++DL     +  ++ E  + S   D+
Sbjct: 1242 ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR--LQTESGEFSRQLDE 1299

Query: 357  KFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVI 393
            K EA++ Q +R  ++   + +E K+Q++     K+ +
Sbjct: 1300 K-EALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNAL 1335



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 74/368 (20%), Positives = 156/368 (42%), Gaps = 32/368 (8%)

Query: 55   LLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKAL--ESNQMECQT------- 105
            LL   E  +++ T++E   K++ EL K     + L +K+  L  E N ++ Q        
Sbjct: 845  LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904

Query: 106  --------ALQKTQLQLQ----EMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQ 153
                     L KT++QL+    E+ ++A     ++ +L A+   L +   EL   +  L+
Sbjct: 905  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964

Query: 154  ---AREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQ 210
               A+ +      + K K++ E +  + +   K    + AL++A       ++ ++D   
Sbjct: 965  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1024

Query: 211  KLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKS---CLHDELLFTVEREKRK-DE 266
             L   KI++ +  +DL     +  + R ++ R K++      L  E +  +E EK++ DE
Sbjct: 1025 TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084

Query: 267  LLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSK--MEESKALD 324
             L   + +     S++ + + + ++ Q  ++ L   +E  +E I+   +     E +  D
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1144

Query: 325  SSRDM--CLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQ 382
             SR++      LE        + E N+K   + QK    L +     +++    ++K   
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204

Query: 383  IDTVFGEK 390
                 GE+
Sbjct: 1205 SVAELGEQ 1212



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 39/211 (18%), Positives = 91/211 (43%), Gaps = 17/211 (8%)

Query: 23   IEKQRKELQLLIGELKDRDKELNDMV--AVHQQQLLSWEEDRQKVL-----TLEERCSKL 75
            I + + E++ ++ E ++ +++    +  A    + L  E+D    L      +E+    L
Sbjct: 1740 ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDL 1799

Query: 76   EGELHKRTEI-IRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEAR 134
            +  L +  ++ ++   K+++ LE+   E +  ++  Q +  E  +         ++L  +
Sbjct: 1800 QLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQ 1859

Query: 135  NETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDA 194
             E     ++ L   V +LQA+       +K   +   EA         KF+ L+H L +A
Sbjct: 1860 TEEDRKNILRLQDLVDKLQAK-------VKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA 1912

Query: 195  KMAETCIVKEKQDYKQKLKALKIEVNKLKED 225
            +  E   + E Q  K ++K+ ++    + E+
Sbjct: 1913 E--ERADIAESQVNKLRVKSREVHTKVISEE 1941



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 23/111 (20%), Positives = 53/111 (47%), Gaps = 11/111 (9%)

Query: 15   GSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQL----LSWEEDRQKVLTLEE 70
            G + +I  +E + +EL+  +   + R+ E    +  H++++       EEDR+ +L L++
Sbjct: 1813 GGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQD 1872

Query: 71   RCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKA 121
               KL+ +       ++S  ++ +  E          +K Q +L+E  ++A
Sbjct: 1873 LVDKLQAK-------VKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERA 1916


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 83/397 (20%), Positives = 173/397 (43%), Gaps = 47/397 (11%)

Query: 11   RQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQL--LSWEEDRQKVLT- 67
            ++   +E ++  + ++   L   I +L    K L +    HQQ L  L  EED+   LT 
Sbjct: 972  KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE---AHQQTLDDLQAEEDKVNTLTK 1028

Query: 68   ----LEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATH 123
                LE++   LEG L +  ++   L +  + LE +    Q ++   + + Q++ +K   
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK 1088

Query: 124  SSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGK 183
                  +L+++ E      ++L  ++ +LQAR + L   I+ +     +A    +D S +
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1148

Query: 184  FKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRL 243
             + +   L +A  A +  ++         K  + E  K++ DL E T + +E     +R 
Sbjct: 1149 LEEISERLEEAGGATSAQIEMN-------KKREAEFQKMRRDLEEATLQ-HEATAATLRK 1200

Query: 244  KQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNV 303
            K   S          E  ++ D L  + K K E+  SE+          + ++  L  NV
Sbjct: 1201 KHADS--------VAELGEQIDNLQRV-KQKLEKEKSEM----------KMEIDDLASNV 1241

Query: 304  E-------NSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQ 356
            E       N +++ +  + ++ E K+ +  +   ++DL     +  ++ E  + S   D+
Sbjct: 1242 ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR--LQTESGEFSRQLDE 1299

Query: 357  KFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVI 393
            K EA++ Q +R  ++   + +E K+Q++     K+ +
Sbjct: 1300 K-EALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNAL 1335



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 74/368 (20%), Positives = 156/368 (42%), Gaps = 32/368 (8%)

Query: 55   LLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKAL--ESNQMECQT------- 105
            LL   E  +++ T++E   K++ EL K     + L +K+  L  E N ++ Q        
Sbjct: 845  LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904

Query: 106  --------ALQKTQLQLQ----EMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQ 153
                     L KT++QL+    E+ ++A     ++ +L A+   L +   EL   +  L+
Sbjct: 905  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964

Query: 154  ---AREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQ 210
               A+ +      + K K++ E +  + +   K    + AL++A       ++ ++D   
Sbjct: 965  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1024

Query: 211  KLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKS---CLHDELLFTVEREKRK-DE 266
             L   KI++ +  +DL     +  + R ++ R K++      L  E +  +E EK++ DE
Sbjct: 1025 TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084

Query: 267  LLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSK--MEESKALD 324
             L   + +     S++ + + + ++ Q  ++ L   +E  +E I+   +     E +  D
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1144

Query: 325  SSRDM--CLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQ 382
             SR++      LE        + E N+K   + QK    L +     +++    ++K   
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204

Query: 383  IDTVFGEK 390
                 GE+
Sbjct: 1205 SVAELGEQ 1212



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 39/211 (18%), Positives = 91/211 (43%), Gaps = 17/211 (8%)

Query: 23   IEKQRKELQLLIGELKDRDKELNDMV--AVHQQQLLSWEEDRQKVL-----TLEERCSKL 75
            I + + E++ ++ E ++ +++    +  A    + L  E+D    L      +E+    L
Sbjct: 1740 ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDL 1799

Query: 76   EGELHKRTEI-IRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEAR 134
            +  L +  ++ ++   K+++ LE+   E +  ++  Q +  E  +         ++L  +
Sbjct: 1800 QLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQ 1859

Query: 135  NETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDA 194
             E     ++ L   V +LQA+       +K   +   EA         KF+ L+H L +A
Sbjct: 1860 TEEDRKNILRLQDLVDKLQAK-------VKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA 1912

Query: 195  KMAETCIVKEKQDYKQKLKALKIEVNKLKED 225
            +  E   + E Q  K ++K+ ++    + E+
Sbjct: 1913 E--ERADIAESQVNKLRVKSREVHTKVISEE 1941



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 23/111 (20%), Positives = 53/111 (47%), Gaps = 11/111 (9%)

Query: 15   GSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQL----LSWEEDRQKVLTLEE 70
            G + +I  +E + +EL+  +   + R+ E    +  H++++       EEDR+ +L L++
Sbjct: 1813 GGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQD 1872

Query: 71   RCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKA 121
               KL+ +       ++S  ++ +  E          +K Q +L+E  ++A
Sbjct: 1873 LVDKLQAK-------VKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERA 1916


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 79/391 (20%), Positives = 165/391 (42%), Gaps = 26/391 (6%)

Query: 11   RQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQL--LSWEEDRQKVLT- 67
            ++   +E ++  + ++   L   I +L    K L +    HQQ L  L  EED+   LT 
Sbjct: 970  KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE---AHQQTLDDLQAEEDKVNTLTK 1026

Query: 68   ----LEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATH 123
                LE++   LEG L +  +I   L +  + LE +    Q +    +   Q++ +K   
Sbjct: 1027 AKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKK 1086

Query: 124  SSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGK 183
                   L+++ E      ++L  ++ +LQAR + L   I+ +     +A    +D S +
Sbjct: 1087 KEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1146

Query: 184  FKMLEHALRDA-----------KMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTE 232
             + +   L +A           K  E    K ++D ++     +     L++   +   E
Sbjct: 1147 LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE 1206

Query: 233  NNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHN-LRQIYVK 291
              EQ + + R+KQ+      E+   ++      E ++ AK   E+    L + L +I  K
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTK 1266

Query: 292  QQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKS 351
            ++   + +N   + + +  ++     E S+ LD  +D  +S L         + E+ ++ 
Sbjct: 1267 EEEQQRLIN---DLTAQRARLQTESGEYSRQLD-EKDTLVSQLSRGKQAFTQQIEELKRQ 1322

Query: 352  LFKDQKFEAMLVQQNRSDKSSCDECKEKKQQ 382
            L ++ K ++ L    +S +  CD  +E+ ++
Sbjct: 1323 LEEEIKAKSALAHALQSSRHDCDLLREQYEE 1353



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 101/475 (21%), Positives = 192/475 (40%), Gaps = 60/475 (12%)

Query: 19   EISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKV----LTLEERCSK 74
            E++  E +RKEL+  +  L     +L   V      L   EE   ++    + LE +  +
Sbjct: 866  ELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKE 925

Query: 75   LEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQ--EMAQKATHSSL--LSED 130
            +        EI   LT K + LE    E +  +   +L L   E  + AT + +  L+E+
Sbjct: 926  VTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 985

Query: 131  LEARNETLSNTLVELSA-------QVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGK 183
            +   +ET++    E  A        +  LQA E  + T+ K K    I+    + D  G 
Sbjct: 986  MAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK----IKLEQQVDDLEGS 1041

Query: 184  FKM-------LEHALR----DAKMAETC---IVKEKQDYKQKLKALKIEVNKLKEDLNEK 229
             +        LE A R    D K+A+     I  +KQ   +KLK  + E++ L+  + ++
Sbjct: 1042 LEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDE 1101

Query: 230  TTENNEQREEIIRLKQEKSCLHDEL----LFTVEREKRKDELLNIAKSKQERTNS----- 280
                 + +++I  L+     L +E+        + EK++ +L    +   ER        
Sbjct: 1102 QALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1161

Query: 281  ----ELHNLRQI-YVKQQSDLQFLNFNVENSQELIQM--YDSKMEESKALDSSRDMCLSD 333
                E++  R+  + K + DL+      E +   ++    DS  E  + +D+ + +    
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV-KQK 1220

Query: 334  LENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKS-- 391
            LE    ++ ++ +    ++    K +  L +  R+ +    E K K+++   +  + +  
Sbjct: 1221 LEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQ 1280

Query: 392  ---VITLSSIFTKDLVEKHNLPWSLG-GK----TQIEPENKITLCKIHTKSPKCH 438
               + T S  +++ L EK  L   L  GK     QIE   +    +I  KS   H
Sbjct: 1281 RARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAH 1335



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 72/368 (19%), Positives = 153/368 (41%), Gaps = 32/368 (8%)

Query: 55   LLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKAL--ESNQMECQT------- 105
            LL   E  +++  ++E   K + EL K     + L +K+  L  E N ++ Q        
Sbjct: 843  LLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSL 902

Query: 106  --------ALQKTQLQLQ----EMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQ 153
                     L KT++QL+    E+ ++A     ++ +L A+   L +   EL   +  L+
Sbjct: 903  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962

Query: 154  ---AREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQ 210
               A+ +      + K K++ E +  + +   K    + AL++A       ++ ++D   
Sbjct: 963  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1022

Query: 211  KLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKS---CLHDELLFTVEREKRK-DE 266
             L   KI++ +  +DL     +  + R ++ R K++      L  E    +E +K++ DE
Sbjct: 1023 TLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDE 1082

Query: 267  LLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSK--MEESKALD 324
             L   + +     S++ + + + ++ Q  ++ L   +E  +E I+   +     E +  D
Sbjct: 1083 KLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1142

Query: 325  SSRDM--CLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQ 382
             SR++      LE        + E N+K   + QK    L +     +++    ++K   
Sbjct: 1143 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1202

Query: 383  IDTVFGEK 390
                 GE+
Sbjct: 1203 SVAELGEQ 1210



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 80/367 (21%), Positives = 147/367 (40%), Gaps = 57/367 (15%)

Query: 69   EERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLS 128
            E+  + ++ E  K  E +     K K LE   +         QLQ+Q  A          
Sbjct: 850  EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLA------ 903

Query: 129  EDLEARNETLSNTLVELSAQVGQLQAR---EQALTTMIKLKDKDIIEAVNHIADCSGKFK 185
             D E R + L  T ++L A++ ++  R   E+ +   +  K + + +      +CS    
Sbjct: 904  -DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLED------ECSE--- 953

Query: 186  MLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQ 245
             L+  + D ++    + KEK   + K+K L  E+  L E + + T E    +E       
Sbjct: 954  -LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE------- 1005

Query: 246  EKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVEN 305
                 H + L  ++ E+ K   L  AK K E+   +L    +   K + DL+     +E 
Sbjct: 1006 ----AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEG 1061

Query: 306  SQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQ------KSLFKDQKFE 359
              +L Q  +S M               D+EN+  ++D K +K +      +S  +D++  
Sbjct: 1062 DLKLAQ--ESTM---------------DIENDKQQLDEKLKKKEFEMSGLQSKIEDEQAL 1104

Query: 360  AMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDLVEKHNLPWSLGGKT-- 417
             M +Q+   +  +  E  E++ + +     K+    S + +++L E        GG T  
Sbjct: 1105 GMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL-SRELEEISERLEEAGGATSA 1163

Query: 418  QIEPENK 424
            QIE   K
Sbjct: 1164 QIEMNKK 1170



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 88/403 (21%), Positives = 162/403 (40%), Gaps = 68/403 (16%)

Query: 17   EVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLE 76
            E E S   ++ K L++ + EL     E++  +A   +++   +  R  +  +E   S L+
Sbjct: 1550 EAEASLEHEEGKILRIQL-ELNQVKSEVDRKIAEKDEEIDQMK--RNHIRIVESMQSTLD 1606

Query: 77   GELHKRTEIIRSLTKKVKALESNQMECQ-------------------TALQKTQLQL--- 114
             E+  R + IR L KK++  + N+ME Q                     L+ TQL L   
Sbjct: 1607 AEIRSRNDAIR-LKKKMEG-DLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDA 1664

Query: 115  --------QEMAQKATHSSLLSEDLEARNETLSNT----------LVELSAQVGQLQARE 156
                    +++A     ++LL  ++E    TL  T          L++ S +V  L  + 
Sbjct: 1665 LRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQN 1724

Query: 157  QALTTMIKLKDKDIIEAVNHIADCSGKFKMLEH----ALRD-AKMAETCIVKEKQDYKQK 211
             +L    K  + DI +    + D   + +  E     A+ D A MAE   +K++QD    
Sbjct: 1725 TSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEE--LKKEQDTSAH 1782

Query: 212  LKALKIEVNKLKEDLNEKTTENNE-----QREEIIRLKQEKSCLHDELLFTVEREKRKDE 266
            L+ +K  + +  +DL  +  E  +      +++I +L+     L  E    VE E++++ 
Sbjct: 1783 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGE----VESEQKRNV 1838

Query: 267  LLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALD-- 324
                   K ER   EL    +   K    LQ L   V+  Q  ++ Y  + EE++     
Sbjct: 1839 EAVKGLRKHERKVKELTYQTEEDRKNILRLQDL---VDKLQAKVKSYKRQAEEAEEQSNV 1895

Query: 325  --SSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQ 365
              S       +LE    + DI   +  K   K ++    ++ +
Sbjct: 1896 NLSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKIISE 1938



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 72/367 (19%), Positives = 150/367 (40%), Gaps = 53/367 (14%)

Query: 23   IEKQRKELQLLIGELKDRDKE----LNDMVAVHQQ-QLLSWEEDRQ---KVLTLEERCSK 74
            +EK  + L+  + E+K +++E    +ND+ A   + Q  S E  RQ   K   + +    
Sbjct: 1249 LEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRG 1308

Query: 75   LEGELHKRTEIIRSLTKKVKA-------LESNQMECQTAL------QKTQLQLQEMAQKA 121
             +    +  E+ R L +++KA       L+S++ +C          Q+ + +LQ    KA
Sbjct: 1309 KQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKA 1368

Query: 122  THS-----SLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNH 176
                    +    D   R E L     +L+ ++   +   +A+       +K      N 
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNE 1428

Query: 177  IADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQ 236
            + D      M++    +A  A   + K+++++ + L   K +  +   +L     E+   
Sbjct: 1429 VEDL-----MIDVERTNAACA--ALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSL 1481

Query: 237  REEIIRLKQEKSCLHDELLFTVEREKR--KDELLNIAKSKQERTNSELHNLRQIYVKQQS 294
              E+ ++K       D+L  T++RE +  + E+ ++ +   E     +H L +I  + + 
Sbjct: 1482 STELFKIKNAYEESLDQLE-TLKRENKNLQQEISDLTEQIAEG-GKRIHELEKIKKQVEQ 1539

Query: 295  DLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFK 354
            +   L   +E ++  ++      EE K L          LE N     +K E ++K   K
Sbjct: 1540 EKSELQAALEEAEASLE-----HEEGKIL-------RIQLELN----QVKSEVDRKIAEK 1583

Query: 355  DQKFEAM 361
            D++ + M
Sbjct: 1584 DEEIDQM 1590



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 24/130 (18%), Positives = 63/130 (48%), Gaps = 15/130 (11%)

Query: 15   GSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQL----LSWEEDRQKVLTLEE 70
            G + +I  +E + +EL+  +   + R+ E    +  H++++       EEDR+ +L L++
Sbjct: 1811 GGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQD 1870

Query: 71   RCSKLEG----------ELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQK 120
               KL+           E  +++ +  S  ++++  E  + E +  + ++Q+    +  +
Sbjct: 1871 LVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQH-ELEEAEERADIAESQVNKLRVKSR 1929

Query: 121  ATHSSLLSED 130
              H+ ++SE+
Sbjct: 1930 EVHTKIISEE 1939


>gi|187761324 shootin1 isoform a [Homo sapiens]
          Length = 631

 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 78/362 (21%), Positives = 158/362 (43%), Gaps = 37/362 (10%)

Query: 39  DRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALES 98
           D +K+L  + ++ +Q +  +E+ R +    +E+C K+  E   R E ++ L +  K   S
Sbjct: 5   DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQE---RDEAVKKLEEFQKI--S 59

Query: 99  NQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQA 158
           + +  +    +  L++++  +++  +  L+  L   N+TL    +   A++G        
Sbjct: 60  HMVIEEVNFMQNHLEIEKTCRESAEA--LATKLNKENKTLKRISMLYMAKLGP-----DV 112

Query: 159 LTTMIKLKDKDIIEAVNHIAD------CSGKFKMLEHALRDAKMAETCIVKEKQDYKQKL 212
           +T  I + D+D     +  A+      C  + K L   +   +  +  +  E ++ K KL
Sbjct: 113 ITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKL 172

Query: 213 KALKIEVNKLKED---LNEKTTENNEQREEIIRLKQEKSCLHDELLFTVERE----KRKD 265
             +  EVNK+K++   LN +  E  +  E+  R+       ++E+   +E E    K+ +
Sbjct: 173 VEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAE 232

Query: 266 ELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDS 325
                   +Q +   + H L Q  +  Q  L+ L+ N + +Q+L +      ++ K L+ 
Sbjct: 233 SFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELE- 291

Query: 326 SRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKS-----SCDECKEKK 380
                   LEN     +I   K Q  L ++ K E  L  QN  +K+     S DE +++ 
Sbjct: 292 ------EQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRV 345

Query: 381 QQ 382
            Q
Sbjct: 346 NQ 347


>gi|50511340 shootin1 isoform b [Homo sapiens]
          Length = 456

 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 78/362 (21%), Positives = 158/362 (43%), Gaps = 37/362 (10%)

Query: 39  DRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALES 98
           D +K+L  + ++ +Q +  +E+ R +    +E+C K+  E   R E ++ L +  K   S
Sbjct: 5   DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQE---RDEAVKKLEEFQKI--S 59

Query: 99  NQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQA 158
           + +  +    +  L++++  +++  +  L+  L   N+TL    +   A++G        
Sbjct: 60  HMVIEEVNFMQNHLEIEKTCRESAEA--LATKLNKENKTLKRISMLYMAKLGP-----DV 112

Query: 159 LTTMIKLKDKDIIEAVNHIAD------CSGKFKMLEHALRDAKMAETCIVKEKQDYKQKL 212
           +T  I + D+D     +  A+      C  + K L   +   +  +  +  E ++ K KL
Sbjct: 113 ITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKL 172

Query: 213 KALKIEVNKLKED---LNEKTTENNEQREEIIRLKQEKSCLHDELLFTVERE----KRKD 265
             +  EVNK+K++   LN +  E  +  E+  R+       ++E+   +E E    K+ +
Sbjct: 173 VEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAE 232

Query: 266 ELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDS 325
                   +Q +   + H L Q  +  Q  L+ L+ N + +Q+L +      ++ K L+ 
Sbjct: 233 SFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELE- 291

Query: 326 SRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKS-----SCDECKEKK 380
                   LEN     +I   K Q  L ++ K E  L  QN  +K+     S DE +++ 
Sbjct: 292 ------EQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRV 345

Query: 381 QQ 382
            Q
Sbjct: 346 NQ 347


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 86/423 (20%), Positives = 173/423 (40%), Gaps = 47/423 (11%)

Query: 24   EKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKRT 83
            E+ + EL+    E +    EL  +   +++ L   E  +++   L+E  S L  +L    
Sbjct: 1461 EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSG 1520

Query: 84   EIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSL------------LSEDL 131
            + I  L K  K LE+ +ME Q+AL++ +  L+    K   + L            L+E  
Sbjct: 1521 KTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD 1580

Query: 132  EARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDK----------DIIEAVNHIADCS 181
            E   +   N L  + +    L A  ++    +++K K           +  A    A+  
Sbjct: 1581 EEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQ 1640

Query: 182  GKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNE-----KTTENNEQ 236
             + K L+  L+D ++     V+   D K+ +  ++   N L+ +L E     + TE + +
Sbjct: 1641 KQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRK 1700

Query: 237  --REEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQS 294
               +E+I   +    LH +    + ++K+ D  L+  +++ E    E  N  +   K  +
Sbjct: 1701 LAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAIT 1760

Query: 295  DLQFLNFNVENSQEL---IQMYDSKMEES-----KALDSSRDMCLSDLENNHPKVDIKRE 346
            D   +   ++  Q+    ++     ME++       LD +  + L   +    K++ +  
Sbjct: 1761 DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR 1820

Query: 347  KNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDLVEK 406
            + +  L  +QK  A  V+  R       E + K+    T    K+++ L     +DLV+K
Sbjct: 1821 ELENELEAEQKRNAESVKGMRK-----SERRIKELTYQTEEDRKNLLRL-----QDLVDK 1870

Query: 407  HNL 409
              L
Sbjct: 1871 LQL 1873



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 87/410 (21%), Positives = 174/410 (42%), Gaps = 73/410 (17%)

Query: 11   RQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQL--LSWEEDRQKVLT- 67
            ++   +E ++  + ++   L  +I +L    K L +    HQQ L  L  EED+   LT 
Sbjct: 966  KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE---AHQQALDDLQAEEDKVNTLTK 1022

Query: 68   ----LEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATH 123
                LE++   LEG L +  ++   L +  + LE +                    K T 
Sbjct: 1023 AKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGD-------------------LKLTQ 1063

Query: 124  SSLLSEDLEARNETLSNTLVELSAQVGQLQAR---EQALTTMIKLKDKDIIEAVNHIADC 180
             S++  DLE   + L   L +   ++  L AR   EQAL + ++ K K++          
Sbjct: 1064 ESIM--DLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL---------- 1111

Query: 181  SGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTT---ENNEQR 237
              + + LE  L   + A   + K + D  ++L+    E+++  E+    T+   E N++R
Sbjct: 1112 QARIEELEEELEAERTARAKVEKLRSDLSRELE----EISERLEEAGGATSVQIEMNKKR 1167

Query: 238  E---EIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQS 294
            E   + +R   E++ L  E      R+K  D +  + +         L  ++Q   K++S
Sbjct: 1168 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQ-----IDNLQRVKQKLEKEKS 1222

Query: 295  ----DLQFLNFNVE-------NSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDI 343
                +L  +  N+E       N +++ +  + +M E ++        ++DL +   K  +
Sbjct: 1223 EFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK--L 1280

Query: 344  KREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVI 393
            + E  + S   D+K EA++ Q  R   +   + ++ K+Q++     K+ +
Sbjct: 1281 QTENGELSRQLDEK-EALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNAL 1329



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 65/288 (22%), Positives = 118/288 (40%), Gaps = 44/288 (15%)

Query: 24   EKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKV----LTLEERCSKLEGEL 79
            E +RKEL+  +  L     +L   V   Q  L   EE   ++    + LE +  ++   L
Sbjct: 867  EARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERL 926

Query: 80   HKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQ--EMAQKATHSSL--LSEDLEARN 135
                E+   LT K + LE    E +  +   +L L   E  + AT + +  L+E++   +
Sbjct: 927  EDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 986

Query: 136  ETLSNTLVELSA-------QVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKM-- 186
            E ++    E  A        +  LQA E  + T+ K K    ++    + D  G  +   
Sbjct: 987  EIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAK----VKLEQQVDDLEGSLEQEK 1042

Query: 187  -----LEHALR----DAKMAETCIV---KEKQDYKQKLKALKIEVNKLKEDLNEKTTENN 234
                 LE A R    D K+ +  I+    +KQ   ++LK    E+N L   + ++    +
Sbjct: 1043 KVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGS 1102

Query: 235  EQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSEL 282
            + ++++  L+     L +EL           E    A++K E+  S+L
Sbjct: 1103 QLQKKLKELQARIEELEEEL-----------EAERTARAKVEKLRSDL 1139



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 73/347 (21%), Positives = 153/347 (44%), Gaps = 35/347 (10%)

Query: 55   LLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQL 114
            LL   E  +++ +++E  ++L+  L K     + L +K+ +L   + + Q  +Q  Q  L
Sbjct: 839  LLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL 898

Query: 115  QEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDI---- 170
             +  ++          LEA+ + ++  L +      +L A+++ L        +DI    
Sbjct: 899  ADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE 958

Query: 171  -----IEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKED 225
                 +E   H  +   K    E A  D  +A+  + KEK       KAL+    +  +D
Sbjct: 959  LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAK--LTKEK-------KALQEAHQQALDD 1009

Query: 226  LNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNL 285
            L  +  + N   +  ++L+Q+     D+L  ++E+EK+    L  AK K E    +L   
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQV----DDLEGSLEQEKKVRMDLERAKRKLE---GDLKLT 1062

Query: 286  RQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKR 345
            ++  +  ++D Q L+  ++     +   ++++E+ +AL S     L +L+    +++ + 
Sbjct: 1063 QESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL 1122

Query: 346  EKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSV 392
            E  + +  K        V++ RSD S   E +E  ++++   G  SV
Sbjct: 1123 EAERTARAK--------VEKLRSDLSR--ELEEISERLEEAGGATSV 1159



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 65/391 (16%), Positives = 158/391 (40%), Gaps = 38/391 (9%)

Query: 11   RQNIGSEVEISTIEKQRKELQLLIGELKDR--DKELNDMVAVHQQQLLSWEEDRQKVLTL 68
            +  + +E+E   ++ +R        + K R  DK L +    +++     E  +++  +L
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL 1477

Query: 69   EERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLS 128
                 KL+    +  E + +  ++ K L+    +    L  +   + E+ +       + 
Sbjct: 1478 STELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEK-------VR 1530

Query: 129  EDLEARNETLSNTLVELSAQVGQLQA---REQALTTMIKLK-DKDIIEAVNHIADCSGKF 184
            + LEA    L + L E  A +   +    R Q     IK + ++ + E    +       
Sbjct: 1531 KQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH 1590

Query: 185  KMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTE----NNEQREEI 240
              +  +L+ +  AET         + + +AL+++  K++ DLNE   +    N    E  
Sbjct: 1591 LRVVDSLQTSLDAET---------RSRNEALRVK-KKMEGDLNEMEIQLSHANRMAAEAQ 1640

Query: 241  IRLKQEKSCLHDELLFTVEREKRKDEL---LNIAKSKQERTNSELHNLRQIYVKQQSDLQ 297
             ++K  +S L D  +   +  +  D+L   + I + +     +EL  LR +  + +   +
Sbjct: 1641 KQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRK 1700

Query: 298  FLNFNVENSQELIQMYDSK----MEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLF 353
                 +  + E +Q+  S+    + + K +D+      +++E    +     EK +K++ 
Sbjct: 1701 LAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAIT 1760

Query: 354  KDQKFEAMLVQQNRSDKSSCDECKEKKQQID 384
                  AM+ ++ + ++ +    +  K+ ++
Sbjct: 1761 D----AAMMAEELKKEQDTSAHLERMKKNME 1787


>gi|188528616 testis specific, 10 [Homo sapiens]
          Length = 698

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 103/481 (21%), Positives = 205/481 (42%), Gaps = 82/481 (17%)

Query: 20  ISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGEL 79
           IST+EK+ K L     +  D + EL    A +    L +E   + +   +   +K + EL
Sbjct: 172 ISTVEKEMKSLAR---KAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYEL 228

Query: 80  HKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQ-----------KATHSSLLS 128
               E I  L +K+       +  +  +      L ++A+           K+ + + L 
Sbjct: 229 QLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLG 288

Query: 129 EDLEARNETLS---NTLVELSAQVGQ----LQAREQALTTMIK------------LKDKD 169
           E L  + +T+S   N + E+     Q    L   EQ ++ M +             +++D
Sbjct: 289 ESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERD 348

Query: 170 IIEAVN-HIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNE 228
           I+   N ++ +   K K    AL   K+ +T    E  D KQK++   +EVNKLK  L  
Sbjct: 349 ILAHDNDNLQEQFAKAKQENQAL-SKKLNDTH--NELNDIKQKVQDTNLEVNKLKNILKS 405

Query: 229 KTTENNEQREEIIRLKQEKSCLHDEL-------------LFTVERE--KRKDELLNIAKS 273
           + +EN +  E++ +  ++     ++              L T E E  + K+++ ++ + 
Sbjct: 406 EESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNRE 465

Query: 274 KQERTN------SELHNLRQIYVKQQSDLQFLNF-------NVENSQELIQMYDSKME-- 318
            ++  N      S++  L +  VK + +LQ + F       ++ +++EL    DS  E  
Sbjct: 466 VEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELL 525

Query: 319 --ESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDEC 376
             +  A D   +M  ++L++ H ++++ R +        Q  EA+LV     +  S    
Sbjct: 526 NRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIAL 585

Query: 377 KEKKQQIDTVFGEKSVITLS----SIFTKDLVEKHNLPWSLGGKTQIEPENKITLCKIHT 432
           +EK+ +I  +   K  + L+    +I ++D+ +  N+       TQ+E +  IT  ++ T
Sbjct: 586 QEKESEIQLL---KEHLCLAENKMAIQSRDVAQFRNV------VTQLEADLDITKRQLGT 636

Query: 433 K 433
           +
Sbjct: 637 E 637



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 62/304 (20%), Positives = 120/304 (39%), Gaps = 49/304 (16%)

Query: 59  EEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKA-LESNQMECQTALQKTQLQLQEM 117
           E +R    T   R +     L +R +I +      KA LE    E +  +     +  E 
Sbjct: 102 ETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQ 161

Query: 118 AQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHI 177
               T        +E   ++L+   ++  +++G+ +A   +L  + +  +KD+ +   H+
Sbjct: 162 MSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHL 221

Query: 178 ADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQR 237
           A                          K+ Y+ +L   KI    L E ++  T +N  QR
Sbjct: 222 A--------------------------KKKYELQLTQEKIMC--LDEKIDNFTRQNIAQR 253

Query: 238 EEII-------RLKQEKSCLHDELLFTVEREKRKDELLNIAKS--KQERTNSELHNLRQI 288
           EEI         L +EK CL   L      +K+ + + ++ +S   +E+T S + N+  I
Sbjct: 254 EEISILGGTLNDLAKEKECLQACL------DKKSENIASLGESLAMKEKTISGMKNI--I 305

Query: 289 YVKQQSDLQFLNFNVENSQELIQM---YDSKMEESKALDSSRDMCLSDLENNHPKVDIKR 345
              +Q+  Q     +   Q++ +M    D   +E   +   RD+   D +N   +    +
Sbjct: 306 AEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAK 365

Query: 346 EKNQ 349
           ++NQ
Sbjct: 366 QENQ 369



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 48/221 (21%), Positives = 89/221 (40%), Gaps = 51/221 (23%)

Query: 185 KMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLK 244
           ++L+   RD +  +  + K    Y++ L  ++  V  LK + ++      + +EEI RL+
Sbjct: 24  ELLKTTTRDREELKCMLEK----YERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLR 79

Query: 245 QE--KSCLHDE------LLFTVEREK------------RKDELLNIAKSKQERTNSE--- 281
           +E  KSC   +      +L  VE E+             +D L    K  QE   +E   
Sbjct: 80  REMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAH 139

Query: 282 -----------LHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMC 330
                      +HNL    ++Q S++  +   +   ++     + K    KA+D+  ++ 
Sbjct: 140 LEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEK-----EMKSLARKAMDTESELG 194

Query: 331 LSDLENNHPKVDIKREKNQKSLFKDQ------KFEAMLVQQ 365
               ENN   + +  E  +K L   Q      K+E  L Q+
Sbjct: 195 RQKAENN--SLRLLYENTEKDLSDTQRHLAKKKYELQLTQE 233


>gi|13376858 testis specific, 10 [Homo sapiens]
          Length = 698

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 103/481 (21%), Positives = 205/481 (42%), Gaps = 82/481 (17%)

Query: 20  ISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGEL 79
           IST+EK+ K L     +  D + EL    A +    L +E   + +   +   +K + EL
Sbjct: 172 ISTVEKEMKSLAR---KAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYEL 228

Query: 80  HKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQ-----------KATHSSLLS 128
               E I  L +K+       +  +  +      L ++A+           K+ + + L 
Sbjct: 229 QLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLG 288

Query: 129 EDLEARNETLS---NTLVELSAQVGQ----LQAREQALTTMIK------------LKDKD 169
           E L  + +T+S   N + E+     Q    L   EQ ++ M +             +++D
Sbjct: 289 ESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERD 348

Query: 170 IIEAVN-HIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNE 228
           I+   N ++ +   K K    AL   K+ +T    E  D KQK++   +EVNKLK  L  
Sbjct: 349 ILAHDNDNLQEQFAKAKQENQAL-SKKLNDTH--NELNDIKQKVQDTNLEVNKLKNILKS 405

Query: 229 KTTENNEQREEIIRLKQEKSCLHDEL-------------LFTVERE--KRKDELLNIAKS 273
           + +EN +  E++ +  ++     ++              L T E E  + K+++ ++ + 
Sbjct: 406 EESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNRE 465

Query: 274 KQERTN------SELHNLRQIYVKQQSDLQFLNF-------NVENSQELIQMYDSKME-- 318
            ++  N      S++  L +  VK + +LQ + F       ++ +++EL    DS  E  
Sbjct: 466 VEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELL 525

Query: 319 --ESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDEC 376
             +  A D   +M  ++L++ H ++++ R +        Q  EA+LV     +  S    
Sbjct: 526 NRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIAL 585

Query: 377 KEKKQQIDTVFGEKSVITLS----SIFTKDLVEKHNLPWSLGGKTQIEPENKITLCKIHT 432
           +EK+ +I  +   K  + L+    +I ++D+ +  N+       TQ+E +  IT  ++ T
Sbjct: 586 QEKESEIQLL---KEHLCLAENKMAIQSRDVAQFRNV------VTQLEADLDITKRQLGT 636

Query: 433 K 433
           +
Sbjct: 637 E 637



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 62/304 (20%), Positives = 120/304 (39%), Gaps = 49/304 (16%)

Query: 59  EEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKA-LESNQMECQTALQKTQLQLQEM 117
           E +R    T   R +     L +R +I +      KA LE    E +  +     +  E 
Sbjct: 102 ETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQ 161

Query: 118 AQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHI 177
               T        +E   ++L+   ++  +++G+ +A   +L  + +  +KD+ +   H+
Sbjct: 162 MSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHL 221

Query: 178 ADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQR 237
           A                          K+ Y+ +L   KI    L E ++  T +N  QR
Sbjct: 222 A--------------------------KKKYELQLTQEKIMC--LDEKIDNFTRQNIAQR 253

Query: 238 EEII-------RLKQEKSCLHDELLFTVEREKRKDELLNIAKS--KQERTNSELHNLRQI 288
           EEI         L +EK CL   L      +K+ + + ++ +S   +E+T S + N+  I
Sbjct: 254 EEISILGGTLNDLAKEKECLQACL------DKKSENIASLGESLAMKEKTISGMKNI--I 305

Query: 289 YVKQQSDLQFLNFNVENSQELIQM---YDSKMEESKALDSSRDMCLSDLENNHPKVDIKR 345
              +Q+  Q     +   Q++ +M    D   +E   +   RD+   D +N   +    +
Sbjct: 306 AEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAK 365

Query: 346 EKNQ 349
           ++NQ
Sbjct: 366 QENQ 369



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 48/221 (21%), Positives = 89/221 (40%), Gaps = 51/221 (23%)

Query: 185 KMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLK 244
           ++L+   RD +  +  + K    Y++ L  ++  V  LK + ++      + +EEI RL+
Sbjct: 24  ELLKTTTRDREELKCMLEK----YERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLR 79

Query: 245 QE--KSCLHDE------LLFTVEREK------------RKDELLNIAKSKQERTNSE--- 281
           +E  KSC   +      +L  VE E+             +D L    K  QE   +E   
Sbjct: 80  REMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAH 139

Query: 282 -----------LHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMC 330
                      +HNL    ++Q S++  +   +   ++     + K    KA+D+  ++ 
Sbjct: 140 LEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEK-----EMKSLARKAMDTESELG 194

Query: 331 LSDLENNHPKVDIKREKNQKSLFKDQ------KFEAMLVQQ 365
               ENN   + +  E  +K L   Q      K+E  L Q+
Sbjct: 195 RQKAENN--SLRLLYENTEKDLSDTQRHLAKKKYELQLTQE 233


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 79/381 (20%), Positives = 165/381 (43%), Gaps = 33/381 (8%)

Query: 11   RQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQL--LSWEEDRQKVLT- 67
            ++   +E ++  + ++   L+  I +L    K L +    HQQ L  L  EED+   L  
Sbjct: 970  KEKHATENKVKNLSEEMTALEENISKLTKEKKSLQE---AHQQTLDDLQVEEDKVNGLIK 1026

Query: 68   ----LEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATH 123
                LE++   LEG L +  ++   L +  + LE +    Q ++   +   Q++ +K   
Sbjct: 1027 INAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKK 1086

Query: 124  SSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGK 183
                   L+A+ +      ++   ++ +LQAR + L   I+ +     +     +D + +
Sbjct: 1087 KEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE 1146

Query: 184  FKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRL 243
             + +   L +A  A +  ++         K  + E  K++ DL E T + +E     +R 
Sbjct: 1147 LEEISERLEEASGATSAQIEMN-------KKREAEFQKMRRDLEEATLQ-HEATAATLRK 1198

Query: 244  KQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNV 303
            KQ  S          E  ++ D L  + K K E+  SE   L+       S+++ L+ + 
Sbjct: 1199 KQADS--------VAELGEQIDNLQRV-KQKLEKEKSE---LKMEIDDMASNIEALSKSK 1246

Query: 304  ENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLV 363
             N +   +  + +  E KA D  +   + DL  N  K  ++ +  + S   ++K E+++ 
Sbjct: 1247 SNIERTCRTVEDQFSEIKAKDEQQTQLIHDL--NMQKARLQTQNGELSHRVEEK-ESLIS 1303

Query: 364  QQNRSDKSSCDECKEKKQQID 384
            Q  +S ++   + +E K+Q++
Sbjct: 1304 QLTKSKQALTQQLEELKRQME 1324



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 83/350 (23%), Positives = 155/350 (44%), Gaps = 27/350 (7%)

Query: 19   EISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEED-----RQKVLTLEERCS 73
            E++  E +RKEL+  +  L     +L   V    + L+  EE      + K+L LE +  
Sbjct: 866  ELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKIL-LEAKVK 924

Query: 74   KLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQ--EMAQKATHSSL--LSE 129
            +L   L +  E+   L  K + LE      +  +   +L L   E  + AT + +  LSE
Sbjct: 925  ELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSE 984

Query: 130  DLEARNETLSNTLVELSAQVGQLQ-AREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLE 188
            ++ A  E +S    +L+ +   LQ A +Q L  +   +DK     VN +   + K +   
Sbjct: 985  EMTALEENIS----KLTKEKKSLQEAHQQTLDDLQVEEDK-----VNGLIKINAKLEQQT 1035

Query: 189  HALRDAKMAETCIVKEKQDYKQKLKA-LKIEVNKLKEDLNEKTTENNEQREEIIRLKQEK 247
              L  +   E  +  + +  K+KL+  LK+    + +  N+K     + +++   L Q +
Sbjct: 1036 DDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQ 1095

Query: 248  SCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDL-QFLNFNVENS 306
            + + DE + +++ +K+  EL    +  +E   +E H LR    KQ+SDL + L    E  
Sbjct: 1096 AKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE-HTLRAKIEKQRSDLARELEEISERL 1154

Query: 307  QELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQ 356
            +E      +++E +K  ++       DLE    +  ++ E    +L K Q
Sbjct: 1155 EEASGATSAQIEMNKKREAEFQKMRRDLE----EATLQHEATAATLRKKQ 1200



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 67/298 (22%), Positives = 127/298 (42%), Gaps = 49/298 (16%)

Query: 55   LLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQL 114
            LL   E  +++ T++E   + + EL +     + L +K+ +L           +K  LQL
Sbjct: 843  LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQ---------EKNDLQL 893

Query: 115  QEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAV 174
            Q   Q  T + +   D E R E L  + + L A+V +L  R +    M    + +++   
Sbjct: 894  Q--VQSETENLM---DAEERCEGLIKSKILLEAKVKELTERLEEEEEM----NSELVAKK 944

Query: 175  NHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENN 234
             ++ D   K   L+  + D ++  T + KEK   + K+K L  E+  L+E++++ T E  
Sbjct: 945  RNLED---KCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKK 1001

Query: 235  EQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQS 294
              +E            H + L  ++ E+ K   L    +K E+   +L    +   K ++
Sbjct: 1002 SLQE-----------AHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRA 1050

Query: 295  DLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSL 352
            DL+     +E         D KM +           + DLEN+  +++ K +K +  L
Sbjct: 1051 DLERAKRKLEG--------DLKMSQES---------IMDLENDKQQIEEKLKKKEFEL 1091



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 78/377 (20%), Positives = 163/377 (43%), Gaps = 40/377 (10%)

Query: 23   IEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKR 82
            +++ + EL+    E +    EL  M   +++ +   E  R++   L+E  S L  ++ + 
Sbjct: 1464 LDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAET 1523

Query: 83   TEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNETLSNTL 142
             + ++   K  K +E  + + Q AL++ +  L+    K     L   +L      L   +
Sbjct: 1524 GKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQL---ELSQVKSELDRKV 1580

Query: 143  VELSAQVGQLQAREQ----ALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHAL--RDAKM 196
            +E   ++ QL+   Q    AL +++  + +   +A+       G    +E  L   + +M
Sbjct: 1581 IEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQM 1640

Query: 197  AETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDEL-- 254
            AET         ++ L+ ++ ++   +  L++    N + +E++  +++    L +EL  
Sbjct: 1641 AET---------QKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEE 1691

Query: 255  ----LFTVEREKR--KDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQE 308
                L   ER +R  + ELL+ A  + +  +S+  +L     K ++D+      VENS  
Sbjct: 1692 MKVALEQTERTRRLSEQELLD-ASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENS-- 1748

Query: 309  LIQMYDSKMEESKALDSSRDMCLSDLENNH-PKVDIKR-EKNQKSLFKDQKFEAMLVQQN 366
             IQ   +  E++K   +   M   +L+        ++R +KN +   KD         Q+
Sbjct: 1749 -IQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKD--------LQH 1799

Query: 367  RSDKSSCDECKEKKQQI 383
            R D++     K  K+QI
Sbjct: 1800 RLDEAEQLALKGGKKQI 1816



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 77/388 (19%), Positives = 162/388 (41%), Gaps = 48/388 (12%)

Query: 16   SEVEISTIEKQRKELQLLIGELKDRDKELNDMVA-VHQQQLLSWEEDRQKVLTLEERCSK 74
            +  +I   +K+  E Q +  +L++   +     A + ++Q  S  E  +++  L+    K
Sbjct: 1161 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK 1220

Query: 75   LEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDL--- 131
            LE E  +    I  +   ++AL  ++   +   +  + Q  E+  K    + L  DL   
Sbjct: 1221 LEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQ 1280

Query: 132  ----EARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKML 187
                + +N  LS+ + E  + + QL   +QALT  ++       E    + + +     +
Sbjct: 1281 KARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLE-------ELKRQMEEETKAKNAM 1333

Query: 188  EHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEK 247
             HAL+ ++  +  +++E+ + +Q+ KA      +L+  L++  +E  + R      K E 
Sbjct: 1334 AHALQSSRH-DCDLLREQYEEEQEAKA------ELQRALSKANSEVAQWRT-----KYET 1381

Query: 248  SCLHDELLFTVEREKRKDEL---LNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVE 304
                D +  T E E+ K +L   L  A+   E  NS+  +L +   + Q +++ L  ++E
Sbjct: 1382 ----DAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLE 1437

Query: 305  NSQELIQMYDSKME---------ESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKD 355
             S       D K           + K  +S  ++  +  E+     ++ + +N      D
Sbjct: 1438 RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVD 1497

Query: 356  QKFEAMLVQQNRSDKSSCDECKEKKQQI 383
            Q     L    R +K+  +E  +  +QI
Sbjct: 1498 Q-----LETLRRENKNLQEEISDLTEQI 1520


>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
           sapiens]
          Length = 724

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 77/385 (20%), Positives = 164/385 (42%), Gaps = 34/385 (8%)

Query: 11  RQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEE 70
           +QN+  + + +     RK       E +  DK+L  +    +  L       +++  LE 
Sbjct: 51  KQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLET 110

Query: 71  RCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSED 130
              K+E  L+       SL+     LE   +E     +  + +  E   +     L  E 
Sbjct: 111 ELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLEL 170

Query: 131 LEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHA 190
           ++ RN+           ++  + A+++ +   +++  + + E+   IA   GK   +E  
Sbjct: 171 MKLRNKR--------ETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKE 222

Query: 191 LRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCL 250
             D K +ET   ++  +Y +++     +V K K D+ +      E+ +EI+ LKQ    L
Sbjct: 223 KIDEK-SET---EKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQS---L 275

Query: 251 HDELLFTVER-----------EKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFL 299
            + ++   ++           EK K++ +N  +   E  N+E+ NL+Q ++ +Q + + L
Sbjct: 276 EENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL 335

Query: 300 NFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPK-VDIKREKNQKSLFKDQKF 358
                  Q+ +Q+ DS +++ K L SS    L   +    K  ++  E+ +++L +  K 
Sbjct: 336 ------QQKELQI-DSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKL 388

Query: 359 EAMLVQQNRSDKSSCDECKEKKQQI 383
           +    Q  R  K   +E K + +++
Sbjct: 389 QQKEEQAERLVKQLEEEAKSRAEEL 413



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 81/370 (21%), Positives = 156/370 (42%), Gaps = 44/370 (11%)

Query: 17  EVEISTIEKQRKEL-----QLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEER 71
           E++I ++ +Q KEL     Q L    ++  KE N      +Q L   ++ +QK    E  
Sbjct: 339 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 398

Query: 72  CSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDL 131
             +LE E   R E ++ L +K+K  E+              +L++ +   T ++LL   L
Sbjct: 399 VKQLEEEAKSRAEELKLLEEKLKGKEA--------------ELEKSSAAHTQATLL---L 441

Query: 132 EARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHAL 191
           + + +++  +L +++AQ    +A   +    +KL++  + E     A      + ++H +
Sbjct: 442 QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA---AKAGKNAEDVQHQI 498

Query: 192 RDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLH 251
              + +    V+   D + K    + E+ ++     +K T+   Q      LKQ++    
Sbjct: 499 LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQ------LKQQEEDFR 552

Query: 252 DELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQS-DLQFLNFNVENSQELI 310
            +L    + E RK E  N      E  N       ++Y K +   LQ   F VE  Q L+
Sbjct: 553 KQL---EDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVE-KQALL 608

Query: 311 QMYDSKMEESKALDSSRDMCLSDLENNHPKVDIK---REKNQKSLFKDQ--KFEAMLVQQ 365
             + +  E+   L+  RD     L + + K  IK   + K++ S  K +  K    L ++
Sbjct: 609 NEHGAAQEQ---LNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKK 665

Query: 366 NRSDKSSCDE 375
            +S+    +E
Sbjct: 666 KQSETKLQEE 675



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 57/236 (24%), Positives = 107/236 (45%), Gaps = 39/236 (16%)

Query: 28  KELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQK----VLTLEERCSKLEGELHKRT 83
           ++L+L    L+++  +        Q Q+L+ E   Q+    +L L+ + +  E E+    
Sbjct: 471 EDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIK--- 527

Query: 84  EIIRSLTKKVKALESNQMECQTALQKTQLQLQE--MAQKATHSSLLSEDLEARN---ETL 138
           EI  S  +K+  L+ NQ++ Q    + QL+ +E   A+K   ++ L+E++       E L
Sbjct: 528 EITVSFLQKITDLQ-NQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEEL 586

Query: 139 SNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAE 198
            N       Q+   +  +QAL      +     E +N I D   K  +L H         
Sbjct: 587 YNKTKPFQLQLDAFEVEKQALLN----EHGAAQEQLNKIRDSYAK--LLGH--------- 631

Query: 199 TCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDEL 254
                  Q+ KQK+K     V KLK++ ++  +E ++ R ++ + KQ ++ L +EL
Sbjct: 632 -------QNLKQKIK----HVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 676


>gi|32698688 citron [Homo sapiens]
          Length = 2027

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 74/369 (20%), Positives = 158/369 (42%), Gaps = 23/369 (6%)

Query: 11   RQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQL--LSWEEDRQKVLTL 68
            +Q    E +   +E Q ++L+  + ++  +D    + +   + +L  +S E + QK L L
Sbjct: 814  QQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQK-LEL 872

Query: 69   EERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLS 128
            + + ++L+  L +R   + +L     ALES   + +T L++T  + +E  Q  T      
Sbjct: 873  KRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR--- 929

Query: 129  EDLEARNETLSNT---LVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFK 185
            ++++ + + L N+   + +L  Q+ QL      L        K + EA     +      
Sbjct: 930  DEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRS 989

Query: 186  MLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQ 245
             ++H  R+    E  +  +KQ     ++ALK     L+E + +    N+E  E+  + + 
Sbjct: 990  EVDHLRREITEREMQLTSQKQT----MEALKTTCTMLEEQVMDLEALNDELLEKERQWEA 1045

Query: 246  EKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVEN 305
             +S L DE      R +    +L+  K  + R +  +   RQ+               E+
Sbjct: 1046 WRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVK---------EH 1096

Query: 306  SQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQ 365
              E++ +  +  E+    +S  D  L+DLE  H  +++     Q+ L  +++ +  L+++
Sbjct: 1097 KAEILALQQALKEQKLKAESLSDK-LNDLEKKHAMLEMNARSLQQKLETERELKQRLLEE 1155

Query: 366  NRSDKSSCD 374
                +   D
Sbjct: 1156 QAKLQQQMD 1164



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 85/411 (20%), Positives = 176/411 (42%), Gaps = 74/411 (18%)

Query: 18   VEISTIEKQRKELQL----LIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCS 73
            VE   +E++ +E Q+    L   LK +++   + + V   Q+     D++   TLE    
Sbjct: 691  VEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKE---TLENMMQ 747

Query: 74   KLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSE-DLE 132
            + E E H++ +I+      + A++S       +L++  ++L E  + A +SSL ++ +++
Sbjct: 748  RHEEEAHEKGKILSEQKAMINAMDSK----IRSLEQRIVELSEANKLAANSSLFTQRNMK 803

Query: 133  ARNETLSNTLVE---LSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEH 189
            A+ E +S    +   L  Q G+L+A+ + L        ++ +E ++H  D S K ++LE 
Sbjct: 804  AQEEMISELRQQKFYLETQAGKLEAQNRKL--------EEQLEKISH-QDHSDKNRLLE- 853

Query: 190  ALRDAKMAETCIVKEKQDYKQKLK-----------------------ALKIEVNKLKEDL 226
               + ++ E  +  E+Q  + K +                       AL+ ++ + K +L
Sbjct: 854  --LETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 911

Query: 227  NEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLN-IAKSKQERTNSELHNL 285
             E T E  E+ + +   + E     D L  +       +E LN + +   E  N   +  
Sbjct: 912  EETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLS 971

Query: 286  RQI---------YVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLEN 336
            +Q+          V+ +S++  L   +   +  +      ME  K   +  +  + DLE 
Sbjct: 972  KQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLE- 1030

Query: 337  NHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDEC--KEKKQQIDT 385
                       N + L K++++EA   +    D+ S  EC  +E ++ +DT
Sbjct: 1031 ---------ALNDELLEKERQWEAW--RSVLGDEKSQFECRVRELQRMLDT 1070



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 80/345 (23%), Positives = 149/345 (43%), Gaps = 32/345 (9%)

Query: 73  SKLEGELHKRTEIIRSLTK--KVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSED 130
           SK  G L +   ++  L    K  ++E   +     LQ +Q +  +M Q+ T       +
Sbjct: 422 SKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSE 481

Query: 131 LEARNETLSNTLVELSAQVGQLQAREQALTTMI----KLKDKDIIEAVNHIADCSGKFKM 186
           +EA    LS   VEL A   Q    EQ L T I     LK + + +A   ++    K   
Sbjct: 482 VEA---VLSQKEVELKASETQRSLLEQDLATYITECSSLK-RSLEQARMEVSQEDDKALQ 537

Query: 187 LEHALRDA--KMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLK 244
           L H +R+   K+ E   +KE Q+Y+ +++ +++ +N+L+EDL      +  +R ++   +
Sbjct: 538 LLHDIREQSRKLQE---IKE-QEYQAQVEEMRLMMNQLEEDL-----VSARRRSDLYESE 588

Query: 245 QEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVE 304
             +S L  E  F  +  + + +LL  AK + +    E   L +I  +QQ  +Q L   +E
Sbjct: 589 LRESRLAAE-EFKRKATECQHKLLK-AKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLE 646

Query: 305 NSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQ 364
            + +        ++  +      +  L  L+N        RE + + + K       L +
Sbjct: 647 KAVKASTEATELLQNIRQAKERAERELEKLQN--------REDSSEGIRKKLVEAEELEE 698

Query: 365 QNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDLVEKHNL 409
           ++R  + S    +   +Q +  + EK +  L +   KDL +K  L
Sbjct: 699 KHREAQVSAQHLEVHLKQKEQHYEEK-IKVLDNQIKKDLADKETL 742


>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
           sapiens]
          Length = 725

 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 78/371 (21%), Positives = 162/371 (43%), Gaps = 41/371 (11%)

Query: 25  KQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKRTE 84
           + +KE Q    +LK  +KE+  ++     Q      DR ++  LE    K+E  L+    
Sbjct: 73  ESKKESQKNDKDLKILEKEIRVLLQERGAQ------DR-RIQDLETELEKMEARLNAALR 125

Query: 85  IIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNETLSNTLVE 144
              SL+     LE   +E     +  + +  E   +     L  E ++ RN+        
Sbjct: 126 EKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKR------- 178

Query: 145 LSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAETCIVKE 204
              ++  + A+++ +   +++  + + E+   IA   GK   +E    D K +ET   ++
Sbjct: 179 -ETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEK-SET---EK 233

Query: 205 KQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVER---- 260
             +Y +++     +V K K D+ +      E+ +EI+ LKQ    L + ++   ++    
Sbjct: 234 LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQS---LEENIVILSKQVEDL 290

Query: 261 -------EKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMY 313
                  EK K++ +N  +   E  N+E+ NL+Q ++ +Q + + L       Q+ +Q+ 
Sbjct: 291 NVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL------QQKELQI- 343

Query: 314 DSKMEESKALDSSRDMCLSDLENNHPK-VDIKREKNQKSLFKDQKFEAMLVQQNRSDKSS 372
           DS +++ K L SS    L   +    K  ++  E+ +++L +  K +    Q  R  K  
Sbjct: 344 DSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQL 403

Query: 373 CDECKEKKQQI 383
            +E K + +++
Sbjct: 404 EEEAKSRAEEL 414



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 81/370 (21%), Positives = 156/370 (42%), Gaps = 44/370 (11%)

Query: 17  EVEISTIEKQRKEL-----QLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEER 71
           E++I ++ +Q KEL     Q L    ++  KE N      +Q L   ++ +QK    E  
Sbjct: 340 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 399

Query: 72  CSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDL 131
             +LE E   R E ++ L +K+K  E+              +L++ +   T ++LL   L
Sbjct: 400 VKQLEEEAKSRAEELKLLEEKLKGKEA--------------ELEKSSAAHTQATLL---L 442

Query: 132 EARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHAL 191
           + + +++  +L +++AQ    +A   +    +KL++  + E     A      + ++H +
Sbjct: 443 QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA---AKAGKNAEDVQHQI 499

Query: 192 RDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLH 251
              + +    V+   D + K    + E+ ++     +K T+   Q      LKQ++    
Sbjct: 500 LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQ------LKQQEEDFR 553

Query: 252 DELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQS-DLQFLNFNVENSQELI 310
            +L    + E RK E  N      E  N       ++Y K +   LQ   F VE  Q L+
Sbjct: 554 KQL---EDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVE-KQALL 609

Query: 311 QMYDSKMEESKALDSSRDMCLSDLENNHPKVDIK---REKNQKSLFKDQ--KFEAMLVQQ 365
             + +  E+   L+  RD     L + + K  IK   + K++ S  K +  K    L ++
Sbjct: 610 NEHGAAQEQ---LNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKK 666

Query: 366 NRSDKSSCDE 375
            +S+    +E
Sbjct: 667 KQSETKLQEE 676



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 57/236 (24%), Positives = 107/236 (45%), Gaps = 39/236 (16%)

Query: 28  KELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQK----VLTLEERCSKLEGELHKRT 83
           ++L+L    L+++  +        Q Q+L+ E   Q+    +L L+ + +  E E+    
Sbjct: 472 EDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIK--- 528

Query: 84  EIIRSLTKKVKALESNQMECQTALQKTQLQLQE--MAQKATHSSLLSEDLEARN---ETL 138
           EI  S  +K+  L+ NQ++ Q    + QL+ +E   A+K   ++ L+E++       E L
Sbjct: 529 EITVSFLQKITDLQ-NQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEEL 587

Query: 139 SNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAE 198
            N       Q+   +  +QAL      +     E +N I D   K  +L H         
Sbjct: 588 YNKTKPFQLQLDAFEVEKQALLN----EHGAAQEQLNKIRDSYAK--LLGH--------- 632

Query: 199 TCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDEL 254
                  Q+ KQK+K     V KLK++ ++  +E ++ R ++ + KQ ++ L +EL
Sbjct: 633 -------QNLKQKIK----HVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 677


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 90/421 (21%), Positives = 174/421 (41%), Gaps = 68/421 (16%)

Query: 23   IEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKV----LTLEERCSKLEGE 78
            +E++ +  Q L  E K   + + ++    ++QL   E  RQK+    +T E +  KLE E
Sbjct: 924  VEEEEERCQHLQAEKKKMQQNIQEL----EEQLEEEESARQKLQLEKVTTEAKLKKLEEE 979

Query: 79   LHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQ-KATHSSLLSE-------- 129
                 +    L K+ K LE    E  T L + + + + +A+ K  H +++++        
Sbjct: 980  QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039

Query: 130  -----DLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDI------IE------ 172
                 +LE     L     +LS Q+ +LQA+   L   +  K++++      +E      
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK 1099

Query: 173  --AVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKI------------- 217
              A+  I +   +   L+  L   + +     K+K+D  ++L+ALK              
Sbjct: 1100 NMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQ 1159

Query: 218  --------EVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLN 269
                    EVN LK+ L E+   +  Q +E   ++Q+ S   +EL   +E+ KR    L 
Sbjct: 1160 ELRSKREQEVNILKKTLEEEAKTHEAQIQE---MRQKHSQAVEELAEQLEQTKRVKANLE 1216

Query: 270  IAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDM 329
             AK   E    EL N  ++ ++ + D +     VE   + +Q+  ++ E  +   + +  
Sbjct: 1217 KAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVT 1276

Query: 330  CLSDLENNHPKVDIKREKNQKSLFKD--------QKFEAMLVQQNRSDKSSCDECKEKKQ 381
             L    +N   +  + +     L KD        Q  + +L ++NR   S   + K+ + 
Sbjct: 1277 KLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVED 1336

Query: 382  Q 382
            +
Sbjct: 1337 E 1337



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 91/443 (20%), Positives = 178/443 (40%), Gaps = 68/443 (15%)

Query: 17   EVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLE 76
            E +   +EK R++L+    +L D+  EL   +A  + QL   EE+ Q  L      +++E
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAAL------ARVE 1093

Query: 77   GELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNE 136
             E  ++   +    KK++ LES   E Q  L+  +   +  A+K      L E+LEA   
Sbjct: 1094 EEAAQKNMAL----KKIRELESQISELQEDLESERAS-RNKAEKQKRD--LGEELEALKT 1146

Query: 137  TLSNTLVELSAQVGQLQAREQALTTMIKLKDKDI--------------IEAVNHIADCSG 182
             L +TL   +AQ      REQ +  + K  +++                +AV  +A+   
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206

Query: 183  KFKMLEHALRDAKMA-----------ETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTT 231
            + K ++  L  AK                +++ K D + K K ++ ++ +L+   NE   
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266

Query: 232  ENNEQREEIIRLKQE-------------------------KSCLHDELLFTVEREKRKDE 266
               E  +++ +L+ E                         +S L D      E  ++K  
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326

Query: 267  LLNIAKSKQERTNSELHNL-RQIYVKQQSDLQFLNFNVENSQELIQMYDSK--MEESKAL 323
            L    K  ++  NS    L  +   K   + Q    + + +    +M DS   +E ++ +
Sbjct: 1327 LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386

Query: 324  DSSRDMCLSDLENNHPKVDIKREKNQKSLFK-DQKFEAMLVQQNRSDKSSCDECKEKKQQ 382
                   L  L   H +     +K +K+  +  Q+ + +LV  +   +S+C+  ++K+++
Sbjct: 1387 KRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN-LEKKQKK 1445

Query: 383  IDTVFGEKSVITLSSIFTKDLVE 405
             D +  E+  I+      +D  E
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAE 1468



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 78/397 (19%), Positives = 167/397 (42%), Gaps = 58/397 (14%)

Query: 8    LAGRQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLL----------- 56
            ++ + ++G  V    +EK ++ L+  + E+K + +EL D +   +   L           
Sbjct: 1510 MSSKDDVGKSVH--ELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567

Query: 57   ------------SWEEDRQKVLTLEERCSKLEGELHKRTEII---RSLTKKVKALES--- 98
                        S E+ +Q V  + E  ++LE E  +R+  +   + L   +K LE+   
Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHID 1627

Query: 99   ----NQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQA 154
                N+ E    L+K Q Q+++  ++   +    E++ A+ +     L  + A++ QLQ 
Sbjct: 1628 SANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQE 1687

Query: 155  REQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQ---- 210
               A     +   ++  E  + IA+ SGK  +   AL + +  E  I + +++ ++    
Sbjct: 1688 ELAAAERAKRQAQQERDELADEIANSSGKGAL---ALEEKRRLEARIAQLEEELEEEQGN 1744

Query: 211  ------KLKALKIEVNKLKEDLN---EKTTENNEQREEIIRLKQEKSCLHDELLFTVERE 261
                  +LK   ++++++  DLN       +N   R+++ R  +E      E+  TV+ +
Sbjct: 1745 TELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSK 1804

Query: 262  KRKDELLNIAKSKQ--ERTNSELHNLRQIYVKQ----QSDLQFLNFNVENSQELIQMYDS 315
             +       AK  Q  E+ ++E    RQ   KQ    +  L+ +   V++ +   + Y  
Sbjct: 1805 YKASITALEAKIAQLEEQLDNETKE-RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1863

Query: 316  KMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSL 352
            + +++          L + E    + +  R K Q+ L
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 83/389 (21%), Positives = 164/389 (42%), Gaps = 42/389 (10%)

Query: 23   IEKQRKELQLLIGEL-KDRDKEL---NDMVAVH--QQQLLSWEEDRQKVLTLE-ERCSKL 75
            + +Q +E+     EL K R+K+L   N +  +   Q QL++ +   Q+ L  E E C++ 
Sbjct: 840  VSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEA 899

Query: 76   EGELHKRT--------EIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLL 127
            E EL  R         EI   L  +V+  E      Q   +K Q  +QE+ ++       
Sbjct: 900  E-ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958

Query: 128  SEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKML 187
             + L+    T    L +L  +   L+ +   L    KL +  I E   ++ +   K K L
Sbjct: 959  RQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSL 1018

Query: 188  -----EHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIR 242
                 +H      + E    +EKQ  +Q+L+  +    KL+ D  + + +  E + +I  
Sbjct: 1019 AKLKNKHEAMITDLEERLRREEKQ--RQELEKTR---RKLEGDSTDLSDQIAELQAQIAE 1073

Query: 243  LKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFN 302
            LK + +   +EL   + R + +    N+A  K     S++  L++    +++        
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133

Query: 303  VENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKN----QKSLFKDQK- 357
              +  E ++   +++E++  LDS+             ++  KRE+     +K+L ++ K 
Sbjct: 1134 KRDLGEELEALKTELEDT--LDSTA---------AQQELRSKREQEVNILKKTLEEEAKT 1182

Query: 358  FEAMLVQQNRSDKSSCDECKEKKQQIDTV 386
             EA + +  +    + +E  E+ +Q   V
Sbjct: 1183 HEAQIQEMRQKHSQAVEELAEQLEQTKRV 1211


>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
           sapiens]
          Length = 1133

 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 87/428 (20%), Positives = 172/428 (40%), Gaps = 63/428 (14%)

Query: 23  IEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQK-----------VLTLEER 71
           +EK ++  + ++G+L   +K         +Q +L  EE+++K           +  LE+ 
Sbjct: 147 VEKHKESYRRILGQLLVAEKS-------RRQTILELEEEKRKHKEYMEKSDEFICLLEQE 199

Query: 72  CSKL--------------EGELHKRTEIIRSLTKKVKAL------ESNQMECQTALQKTQ 111
           C +L              E E  KR   ++    K+K+       E  ++  Q  LQ+ +
Sbjct: 200 CERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQK 259

Query: 112 LQLQEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDI- 170
           +Q      K TH+ L   +   + E    T +E   Q    +  +   T M KL ++D  
Sbjct: 260 IQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQ 319

Query: 171 -IEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLK-------ALKIEVNKL 222
             +    +A  S +   LE   R  + AE    +E QD K+K+         +  EV   
Sbjct: 320 NRQLQQKLAALSRQIDELEETNRSLRKAE----EELQDIKEKISKGEYGNAGIMAEV--- 372

Query: 223 KEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSEL 282
            E+L ++  +   + EE+I+++++   L+  L    ERE  + +   +   K  +    L
Sbjct: 373 -EELRKRVLDMEGKDEELIKMEEQCRDLNKRL----ERETLQSKDFKLEVEKLSKRIMAL 427

Query: 283 HNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNH--PK 340
             L   + K + +   L  N+E  +   +    ++E  K      +   S LE      K
Sbjct: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK 487

Query: 341 VDIKREKNQKSLFKDQKFEAMLVQQNRSDK--SSCDECKEKKQQIDTVFGEKSVITLSSI 398
            D+ + K    +F D++       +   DK  ++  + + ++ ++ TV  +    T  ++
Sbjct: 488 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRAL 547

Query: 399 FTKDLVEK 406
            +K  VE+
Sbjct: 548 KSKTDVEE 555



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 72/337 (21%), Positives = 144/337 (42%), Gaps = 39/337 (11%)

Query: 15  GSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSK 74
           G + E+  +E+Q ++L   +     + K+    V    +++++ E+        ++ C  
Sbjct: 384 GKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS 443

Query: 75  LEGELHKRTEIIRSLTKKVKALESNQMECQ---TALQKTQLQLQE-MAQKATHSSLLSED 130
           L+  L K     + L++++++L+    E +   + L+KT+  L+E + +  T + +  ++
Sbjct: 444 LKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDE 503

Query: 131 LEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHA 190
            +  +E L  T  +L A   QLQ  +  +TT+ +   ++   A+    D   K       
Sbjct: 504 RKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKM------ 557

Query: 191 LRDAKMAETCIVKEKQDYKQKLKA-------LKIEVNKLKEDLNE---------KTTENN 234
                     + KE+ D K KLKA       L   VN LK  L           K   N 
Sbjct: 558 --------YSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQ 609

Query: 235 EQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQS 294
           +  +    L QE + +  EL   VER K K + +   +    +T  E   L + Y  ++ 
Sbjct: 610 DSGKSTTALHQENNKI-KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERD 668

Query: 295 DLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCL 331
             QFL+  +E+    ++M  +K + ++  ++S +  L
Sbjct: 669 KAQFLSKELEH----VKMELAKYKLAEKTETSHEQWL 701


>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
           sapiens]
          Length = 1135

 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 87/428 (20%), Positives = 172/428 (40%), Gaps = 63/428 (14%)

Query: 23  IEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQK-----------VLTLEER 71
           +EK ++  + ++G+L   +K         +Q +L  EE+++K           +  LE+ 
Sbjct: 147 VEKHKESYRRILGQLLVAEKS-------RRQTILELEEEKRKHKEYMEKSDEFICLLEQE 199

Query: 72  CSKL--------------EGELHKRTEIIRSLTKKVKAL------ESNQMECQTALQKTQ 111
           C +L              E E  KR   ++    K+K+       E  ++  Q  LQ+ +
Sbjct: 200 CERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQK 259

Query: 112 LQLQEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDI- 170
           +Q      K TH+ L   +   + E    T +E   Q    +  +   T M KL ++D  
Sbjct: 260 IQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQ 319

Query: 171 -IEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLK-------ALKIEVNKL 222
             +    +A  S +   LE   R  + AE    +E QD K+K+         +  EV   
Sbjct: 320 NRQLQQKLAALSRQIDELEETNRSLRKAE----EELQDIKEKISKGEYGNAGIMAEV--- 372

Query: 223 KEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSEL 282
            E+L ++  +   + EE+I+++++   L+  L    ERE  + +   +   K  +    L
Sbjct: 373 -EELRKRVLDMEGKDEELIKMEEQCRDLNKRL----ERETLQSKDFKLEVEKLSKRIMAL 427

Query: 283 HNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNH--PK 340
             L   + K + +   L  N+E  +   +    ++E  K      +   S LE      K
Sbjct: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK 487

Query: 341 VDIKREKNQKSLFKDQKFEAMLVQQNRSDK--SSCDECKEKKQQIDTVFGEKSVITLSSI 398
            D+ + K    +F D++       +   DK  ++  + + ++ ++ TV  +    T  ++
Sbjct: 488 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRAL 547

Query: 399 FTKDLVEK 406
            +K  VE+
Sbjct: 548 KSKTDVEE 555



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 72/337 (21%), Positives = 144/337 (42%), Gaps = 39/337 (11%)

Query: 15  GSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSK 74
           G + E+  +E+Q ++L   +     + K+    V    +++++ E+        ++ C  
Sbjct: 384 GKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS 443

Query: 75  LEGELHKRTEIIRSLTKKVKALESNQMECQ---TALQKTQLQLQE-MAQKATHSSLLSED 130
           L+  L K     + L++++++L+    E +   + L+KT+  L+E + +  T + +  ++
Sbjct: 444 LKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDE 503

Query: 131 LEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHA 190
            +  +E L  T  +L A   QLQ  +  +TT+ +   ++   A+    D   K       
Sbjct: 504 RKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKM------ 557

Query: 191 LRDAKMAETCIVKEKQDYKQKLKA-------LKIEVNKLKEDLNE---------KTTENN 234
                     + KE+ D K KLKA       L   VN LK  L           K   N 
Sbjct: 558 --------YSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQ 609

Query: 235 EQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQS 294
           +  +    L QE + +  EL   VER K K + +   +    +T  E   L + Y  ++ 
Sbjct: 610 DSGKSTTALHQENNKI-KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERD 668

Query: 295 DLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCL 331
             QFL+  +E+    ++M  +K + ++  ++S +  L
Sbjct: 669 KAQFLSKELEH----VKMELAKYKLAEKTETSHEQWL 701


>gi|42794779 myosin 18A isoform b [Homo sapiens]
          Length = 2039

 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 71/384 (18%), Positives = 168/384 (43%), Gaps = 19/384 (4%)

Query: 14   IGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCS 73
            +  E E+  I  Q  + +  + ++K   K+L D+ A  + Q    +E    +  LE+   
Sbjct: 1517 VSLEAELQDISSQESKDEASLAKVK---KQLRDLEAKVKDQEEELDEQAGTIQMLEQAKL 1573

Query: 74   KLEGELHK-RTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLE 132
            +LE E+ + R    + +  + + +E  +  CQ  L++ ++QL+E  +          +LE
Sbjct: 1574 RLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELE 1633

Query: 133  ARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDI-IEAVNHIADCSGKFKMLEHAL 191
             +  TLS+ +     +  + + R+    T   L D  + ++ + + A    +   L++ L
Sbjct: 1634 GKLATLSDQVNRRDFE-SEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQL 1692

Query: 192  RDAKMAETCIVKEKQDYKQKLKALKIEVNK-------LKEDLNEKTTENNEQREEIIRLK 244
             +++      VK ++  + +++ L ++++        L+E L+    E NE +  +   +
Sbjct: 1693 EESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQ 1752

Query: 245  QEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFN-- 302
            ++ + L  +    V +  R    +N  +++ E  N E   L++     QS ++FL  +  
Sbjct: 1753 EDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMV 1812

Query: 303  ----VENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKF 358
                V   +  I+  ++++E  +      +   S L+ N  K+  +R++   +  ++++ 
Sbjct: 1813 DKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQ 1872

Query: 359  EAMLVQQNRSDKSSCDECKEKKQQ 382
               L +Q R  K    E   K+ +
Sbjct: 1873 NKRLQRQLRDTKEEMGELARKEAE 1896



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 82/408 (20%), Positives = 173/408 (42%), Gaps = 38/408 (9%)

Query: 17   EVEISTIEKQRKELQLLIGELK-----DRDKELNDMVAVHQQQLLSWEEDRQKVLTLEER 71
            + +   ++KQ + +++ + E +     + + E++D  A  + +L      R+   T +  
Sbjct: 1330 QTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRL 1389

Query: 72   CSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDL 131
              + E +L    +  R L +++  L+++  E Q ALQ+ + + Q +  +   + L  E  
Sbjct: 1390 QQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQ 1449

Query: 132  EARNETLSNTLVELSAQVGQL--QAREQALTTMIKLKDKDII------------EAVNHI 177
            + RN  L        +++ Q   +A+ + L      ++KD++            E    I
Sbjct: 1450 QVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDI 1509

Query: 178  ADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQR 237
            A  + K   LE  L+D    E+         K++L+ L+ +V   +E+L+E+        
Sbjct: 1510 AGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLE 1569

Query: 238  EEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDL- 296
            +  +RL+ E   +      + E E R +E+    +S Q++       L + Y  +Q  L 
Sbjct: 1570 QAKLRLEMEMERMRQ--THSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLR 1627

Query: 297  --QFLNFNVENSQELIQMYDSKMEE--------SKALDSSRDMCLSDLENNHP-KVDIKR 345
              + L   +    + +   D + E+        +KAL +   + L  L+N+ P K +I +
Sbjct: 1628 EKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQ 1687

Query: 346  EKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVI 393
             KNQ    ++ +F      + R  K+   E ++   QID +   K+ +
Sbjct: 1688 LKNQ---LEESEFTCAAAVKAR--KAMEVEIEDLHLQIDDIAKAKTAL 1730



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 40/162 (24%), Positives = 74/162 (45%), Gaps = 15/162 (9%)

Query: 8    LAGRQNIGSEVEISTIEKQ--RKELQLLIGELKDRDKELNDMVAVHQQQL------LSWE 59
            LA   ++ +++E +  EKQ  +++LQ L  +++  ++ + D   V +Q+          E
Sbjct: 1773 LAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLE 1832

Query: 60   EDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQ 119
             +R +V  LE   S+L+  + K TE            +      Q  L+ T+ ++ E+A+
Sbjct: 1833 FERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELAR 1892

Query: 120  KATHSSLLS-------EDLEARNETLSNTLVELSAQVGQLQA 154
            K   +S          E LEA N++L   L     ++G LQA
Sbjct: 1893 KEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQA 1934


>gi|28416946 myosin 18A isoform a [Homo sapiens]
          Length = 2054

 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 71/384 (18%), Positives = 168/384 (43%), Gaps = 19/384 (4%)

Query: 14   IGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCS 73
            +  E E+  I  Q  + +  + ++K   K+L D+ A  + Q    +E    +  LE+   
Sbjct: 1517 VSLEAELQDISSQESKDEASLAKVK---KQLRDLEAKVKDQEEELDEQAGTIQMLEQAKL 1573

Query: 74   KLEGELHK-RTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLE 132
            +LE E+ + R    + +  + + +E  +  CQ  L++ ++QL+E  +          +LE
Sbjct: 1574 RLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELE 1633

Query: 133  ARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDI-IEAVNHIADCSGKFKMLEHAL 191
             +  TLS+ +     +  + + R+    T   L D  + ++ + + A    +   L++ L
Sbjct: 1634 GKLATLSDQVNRRDFE-SEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQL 1692

Query: 192  RDAKMAETCIVKEKQDYKQKLKALKIEVNK-------LKEDLNEKTTENNEQREEIIRLK 244
             +++      VK ++  + +++ L ++++        L+E L+    E NE +  +   +
Sbjct: 1693 EESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQ 1752

Query: 245  QEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFN-- 302
            ++ + L  +    V +  R    +N  +++ E  N E   L++     QS ++FL  +  
Sbjct: 1753 EDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMV 1812

Query: 303  ----VENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKF 358
                V   +  I+  ++++E  +      +   S L+ N  K+  +R++   +  ++++ 
Sbjct: 1813 DKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQ 1872

Query: 359  EAMLVQQNRSDKSSCDECKEKKQQ 382
               L +Q R  K    E   K+ +
Sbjct: 1873 NKRLQRQLRDTKEEMGELARKEAE 1896



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 82/408 (20%), Positives = 173/408 (42%), Gaps = 38/408 (9%)

Query: 17   EVEISTIEKQRKELQLLIGELK-----DRDKELNDMVAVHQQQLLSWEEDRQKVLTLEER 71
            + +   ++KQ + +++ + E +     + + E++D  A  + +L      R+   T +  
Sbjct: 1330 QTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRL 1389

Query: 72   CSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDL 131
              + E +L    +  R L +++  L+++  E Q ALQ+ + + Q +  +   + L  E  
Sbjct: 1390 QQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQ 1449

Query: 132  EARNETLSNTLVELSAQVGQL--QAREQALTTMIKLKDKDII------------EAVNHI 177
            + RN  L        +++ Q   +A+ + L      ++KD++            E    I
Sbjct: 1450 QVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDI 1509

Query: 178  ADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQR 237
            A  + K   LE  L+D    E+         K++L+ L+ +V   +E+L+E+        
Sbjct: 1510 AGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLE 1569

Query: 238  EEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDL- 296
            +  +RL+ E   +      + E E R +E+    +S Q++       L + Y  +Q  L 
Sbjct: 1570 QAKLRLEMEMERMRQ--THSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLR 1627

Query: 297  --QFLNFNVENSQELIQMYDSKMEE--------SKALDSSRDMCLSDLENNHP-KVDIKR 345
              + L   +    + +   D + E+        +KAL +   + L  L+N+ P K +I +
Sbjct: 1628 EKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQ 1687

Query: 346  EKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVI 393
             KNQ    ++ +F      + R  K+   E ++   QID +   K+ +
Sbjct: 1688 LKNQ---LEESEFTCAAAVKAR--KAMEVEIEDLHLQIDDIAKAKTAL 1730



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 44/199 (22%), Positives = 90/199 (45%), Gaps = 20/199 (10%)

Query: 8    LAGRQNIGSEVEISTIEKQ--RKELQLLIGELKDRDKELNDMVAVHQQQL------LSWE 59
            LA   ++ +++E +  EKQ  +++LQ L  +++  ++ + D   V +Q+          E
Sbjct: 1773 LAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLE 1832

Query: 60   EDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQ 119
             +R +V  LE   S+L+  + K TE            +      Q  L+ T+ ++ E+A+
Sbjct: 1833 FERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELAR 1892

Query: 120  KATHSSLLS-------EDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIE 172
            K   +S          E LEA N++L   L     ++G LQA  +      +++  +  +
Sbjct: 1893 KEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIED-----EMESDENED 1947

Query: 173  AVNHIADCSGKFKMLEHAL 191
             +N + D   K++  ++ L
Sbjct: 1948 LINSLQDMVTKYQKRKNKL 1966


>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
          Length = 1213

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 79/409 (19%), Positives = 179/409 (43%), Gaps = 34/409 (8%)

Query: 15  GSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSK 74
           G + EI+  E Q +EL+  + E +   KEL   V   Q+++   E+  +     +  C++
Sbjct: 392 GKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQ 451

Query: 75  LEGELHKRTEIIRSLTKKVKALES--NQMEC-QTALQKTQLQLQEMAQKATHSSLLSEDL 131
           L   L K   + + L  +++ ++S   ++EC ++ L+K +L L++   K    +++  D 
Sbjct: 452 LHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVD- 510

Query: 132 EARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHAL 191
           E +N         +  ++ Q + +   L    K++   +++    + + S K   L+  +
Sbjct: 511 ERKN---------MMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEM 561

Query: 192 RDAKMAETCIVKEKQDYKQKLKALKIEVNKL--KEDLNEKTTENNEQREEII-----RLK 244
            +       + +E+ +   KLK+ + + ++L    DL +K  +  E+ E  I     R  
Sbjct: 562 EEKVYN---LTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKG 618

Query: 245 QEKSCLHD----ELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLN 300
            E +C  D    EL   +ER K++ + L + +    +T  E   L Q +  +Q    FL+
Sbjct: 619 SELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLS 678

Query: 301 FNVENSQELIQMYDSKMEESKALDSSRDM----CLSDLENNHPKVDIK--REKNQKSLFK 354
             +E  +  I   +  +E+ + +    ++     L + ++   K +++  +EK  + + K
Sbjct: 679 QQLEEIKHQIAK-NKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNK 737

Query: 355 DQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDL 403
           + +   + V  +   +   +E  + K     V      + LS  +++ L
Sbjct: 738 EDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRAL 786



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 93/421 (22%), Positives = 183/421 (43%), Gaps = 71/421 (16%)

Query: 17  EVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLE------- 69
           ++ I  +  Q +++Q L  +L++ +++L  + +  +       EDRQK+L LE       
Sbjct: 255 QMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSK-------EDRQKLLKLEVDFEHKA 307

Query: 70  --------ERCSKLEG-ELHKRTEIIR--SLTKKVKALESNQMECQTALQKTQLQLQEMA 118
                   E  +KL   E H R   ++   LT++++ LE    E    LQK + +LQE+ 
Sbjct: 308 SRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELE----ETNKNLQKAEEELQELR 363

Query: 119 QKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIA 178
            K       +  L A  E L   ++E+  +  ++   E     +     K + E  +H  
Sbjct: 364 DKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCREL----RKKLQEEEHHSK 419

Query: 179 DCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNE--------KT 230
           +   + + L+  + + +  E    K K +  Q    L+ E N  K+ LNE        K 
Sbjct: 420 ELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKE 479

Query: 231 TENNEQR---------EEIIRLKQEKSCLHDE---LLFTVEREKRKDELLN----IAKSK 274
            E +E R         +++ +LK     L DE   ++  +++E+RK + LN    + + K
Sbjct: 480 LECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGK 539

Query: 275 QERTNSELHNLRQIYVKQQSDLQFLNFNVENSQ-ELIQMYDSKMEESKALDSSRDMCLSD 333
                 +L    +  +K +S+++   +N+   + ELI    S+ E+S  L  S D+    
Sbjct: 540 VMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKR 599

Query: 334 LEN-NHPKVDIKREKNQK----SLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFG 388
           L+     + +I R +++K    +  +D K + + ++  R         K++ QQ++ V G
Sbjct: 600 LDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIER--------LKKRLQQLEVVEG 651

Query: 389 E 389
           +
Sbjct: 652 D 652



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 85/489 (17%), Positives = 193/489 (39%), Gaps = 93/489 (19%)

Query: 9   AGRQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTL 68
           AG +++  + +      ++++  +  G +K   K   +     ++ L   +ED  ++L++
Sbjct: 27  AGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSI 86

Query: 69  EERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLS 128
                 +EGEL  R ++I  L  K +  +   +E      + +  L+ + + A    +L+
Sbjct: 87  ------MEGELQAREDVIHML--KTEKTKPEVLEAHYGSAEPEKVLRVLHRDA----ILA 134

Query: 129 EDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLE 188
           ++     +     + EL       +  E+   T  ++ ++ ++    H        +   
Sbjct: 135 QEKSIGEDVYEKPISELD------RLEEKQKETYRRMLEQLLLAEKCH--------RRTV 180

Query: 189 HALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLN----EKTTEN----NEQREEI 240
           + L + K   T  + +  D+   L+  +  + KL E        K  EN    N+ R+E+
Sbjct: 181 YELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDEL 240

Query: 241 IRLKQEKSCLHDELLFTVE----------------REKRKDELLNIAKSKQER------- 277
           ++LK     L DE    +E                RE+ +      +KSK++R       
Sbjct: 241 VKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLE 300

Query: 278 ---------------------TNSELHNLRQIYVK------QQSDLQFLNFNVENSQELI 310
                                 N E HN RQ+ +K      +  +L+  N N++ ++E +
Sbjct: 301 VDFEHKASRFSQEHEEMNAKLANQESHN-RQLRLKLVGLTQRIEELEETNKNLQKAEEEL 359

Query: 311 QMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDK 370
           Q    K+ + +  +SS    ++++EN   +V ++ E   + + K +     L ++ + ++
Sbjct: 360 QELRDKIAKGECGNSS---LMAEVENLRKRV-LEMEGKDEEITKTESQCRELRKKLQEEE 415

Query: 371 SSCDECKEKKQQIDTVFGEKSVITLSSIFTKDLVEKHNLPWSLGGKTQIEPE--NKITLC 428
               E + + +++     E  +  L   F+K   E   L  +L  +  +  +  N++ + 
Sbjct: 416 HHSKELRLEVEKLQKRMSE--LEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVV 473

Query: 429 KIHTKSPKC 437
           K   K  +C
Sbjct: 474 KSRVKELEC 482


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 83/400 (20%), Positives = 166/400 (41%), Gaps = 36/400 (9%)

Query: 11   RQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEE 70
            R+N+ +++E    EK  +E QL+    K ++K  ND+      +++    D    LT   
Sbjct: 853  RENL-ADMEAKFREKDEREEQLI----KAKEKLENDIA-----EIMKMSGDNSSQLT--- 899

Query: 71   RCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHS-SLLSE 129
               K+  EL  +   +  L  K+     N    Q +++   ++ ++  Q+A        +
Sbjct: 900  ---KMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 956

Query: 130  DLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNH-IADCSGKFKMLE 188
            +LE +   L   +     Q  +L+AR +  T+  K K ++I++ +   + D   K K   
Sbjct: 957  ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAR 1016

Query: 189  HALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTEN----NEQREEIIRLK 244
                ++ + +      KQ  K K      +  ++ E + ++ TE      + ++   +L+
Sbjct: 1017 E--ENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1074

Query: 245  QEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFL-NFNV 303
             E   L +  L  VE   +  ELL +   K E    E+  L+Q   ++   L  L   NV
Sbjct: 1075 NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENV 1134

Query: 304  ENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLV 363
            + ++EL +  D      K L+  R +  + L        ++ +K +    KD   E   +
Sbjct: 1135 KLAEELGRSRDEVTSHQK-LEEERSVLNNQL--------LEMKKRESKFIKDADEEKASL 1185

Query: 364  QQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDL 403
            Q++ S  S+     EK  +++ +  E +V+   +   K L
Sbjct: 1186 QKSISITSAL--LTEKDAELEKLRNEVTVLRGENASAKSL 1223



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 68/375 (18%), Positives = 161/375 (42%), Gaps = 19/375 (5%)

Query: 19   EISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVL----TLEERCSK 74
            ++   EKQ K L++       +   +   +   + +L + +E+  +V     TLE+    
Sbjct: 750  QLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQI 809

Query: 75   LEGELHKRTE----IIRSLTKKVKALESNQME---CQTALQKTQLQLQEMAQKATHSSLL 127
            L+ +  + +E    + RS+ + V  L   + +     + L+K +  L +M  K       
Sbjct: 810  LKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER 869

Query: 128  SEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKML 187
             E L    E L N + E+    G   ++   +   ++LK++D+ E    +   +     L
Sbjct: 870  EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFL 929

Query: 188  EHALRDAKM-AETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQE 246
            + ++ D  + AE    +  + ++++ K L+ +++ L++ +     +  E +    R   E
Sbjct: 930  QKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSE 989

Query: 247  KSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENS 306
                H+E+L  +++     E  +  K  +E  +  L  L ++  ++Q+D        E++
Sbjct: 990  TKTKHEEILQNLQKTLLDTE--DKLKGAREENSGLLQELEEL--RKQADKAKAAQTAEDA 1045

Query: 307  QELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQN 366
             ++++    +  E+ A         + L+N   ++D  +E N K++ +  K + +L  +N
Sbjct: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQN---ELDTLKENNLKNVEELNKSKELLTVEN 1102

Query: 367  RSDKSSCDECKEKKQ 381
            +  +    E +  KQ
Sbjct: 1103 QKMEEFRKEIETLKQ 1117



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 83/407 (20%), Positives = 169/407 (41%), Gaps = 58/407 (14%)

Query: 19   EISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGE 78
            ++   E + KEL++L  +  ++ K +++  +    QL + EE    +  L +  S+ + E
Sbjct: 688  KLQEAEIKVKELEVLQAKCNEQTKVIDNFTS----QLKATEEKLLDLDALRKASSEGKSE 743

Query: 79   LHKRTEIIRSLTKKVKALE-------SNQMECQTALQKTQLQLQEMAQKATHSSLLSEDL 131
            + K  + + +  K++K LE       S        LQ  +L+L  + +  +  S + E L
Sbjct: 744  MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 803

Query: 132  EARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDK-------DIIEAVNHIADCSGKF 184
            E   + L     E S +   +Q   Q     +  K++       D+ +   ++AD   KF
Sbjct: 804  EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 863

Query: 185  KMLEHALRDAKMAETCIVKEKQDYKQKLKAL-------KIEVNKLKEDLNEKTTENNEQR 237
                   R+    E  ++K K+  +  +  +         ++ K+ ++L  K  +  E +
Sbjct: 864  -------REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQ 916

Query: 238  EEIIRLKQEKSCLHDELL-FTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDL 296
             ++ +  +  S L   +   TV+ E+ + E    A  K E    EL        ++ SDL
Sbjct: 917  LKLTKANENASFLQKSIEDMTVKAEQSQQE----AAKKHEEEKKELE-------RKLSDL 965

Query: 297  Q-FLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLE----NNHPKVDIKREKNQKS 351
            +  +  +    QEL   Y+    E+K   +  +  L +L+    +   K+   RE+N   
Sbjct: 966  EKKMETSHNQCQELKARYERATSETK---TKHEEILQNLQKTLLDTEDKLKGAREENSGL 1022

Query: 352  LFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSI 398
            L   Q+ E +   + ++DK+   +  E   QI     ++   TL+S+
Sbjct: 1023 L---QELEEL---RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASL 1063



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 34/154 (22%), Positives = 74/154 (48%), Gaps = 12/154 (7%)

Query: 17   EVEISTIEKQRKELQLLIGE-LKDRDKE---LNDMVAVHQQQLLSWEEDRQKVLTLEERC 72
            E E S +  Q  E++    + +KD D+E   L   +++    L   + + +K   L    
Sbjct: 1154 EEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEK---LRNEV 1210

Query: 73   SKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLE 132
            + L GE        +SL   V+ LES++++ +  ++  +LQL+E  ++ + SS  ++   
Sbjct: 1211 TVLRGE----NASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQA 1266

Query: 133  ARNETLSNTLVE-LSAQVGQLQAREQALTTMIKL 165
              +E    + ++ L++ +  LQ + Q L   +++
Sbjct: 1267 DEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEM 1300


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 83/400 (20%), Positives = 166/400 (41%), Gaps = 36/400 (9%)

Query: 11   RQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEE 70
            R+N+ +++E    EK  +E QL+    K ++K  ND+      +++    D    LT   
Sbjct: 888  RENL-ADMEAKFREKDEREEQLI----KAKEKLENDIA-----EIMKMSGDNSSQLT--- 934

Query: 71   RCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHS-SLLSE 129
               K+  EL  +   +  L  K+     N    Q +++   ++ ++  Q+A        +
Sbjct: 935  ---KMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 991

Query: 130  DLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNH-IADCSGKFKMLE 188
            +LE +   L   +     Q  +L+AR +  T+  K K ++I++ +   + D   K K   
Sbjct: 992  ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAR 1051

Query: 189  HALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTEN----NEQREEIIRLK 244
                ++ + +      KQ  K K      +  ++ E + ++ TE      + ++   +L+
Sbjct: 1052 E--ENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1109

Query: 245  QEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFL-NFNV 303
             E   L +  L  VE   +  ELL +   K E    E+  L+Q   ++   L  L   NV
Sbjct: 1110 NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENV 1169

Query: 304  ENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLV 363
            + ++EL +  D      K L+  R +  + L        ++ +K +    KD   E   +
Sbjct: 1170 KLAEELGRSRDEVTSHQK-LEEERSVLNNQL--------LEMKKRESKFIKDADEEKASL 1220

Query: 364  QQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDL 403
            Q++ S  S+     EK  +++ +  E +V+   +   K L
Sbjct: 1221 QKSISITSAL--LTEKDAELEKLRNEVTVLRGENASAKSL 1258



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 68/375 (18%), Positives = 161/375 (42%), Gaps = 19/375 (5%)

Query: 19   EISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVL----TLEERCSK 74
            ++   EKQ K L++       +   +   +   + +L + +E+  +V     TLE+    
Sbjct: 785  QLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQI 844

Query: 75   LEGELHKRTE----IIRSLTKKVKALESNQME---CQTALQKTQLQLQEMAQKATHSSLL 127
            L+ +  + +E    + RS+ + V  L   + +     + L+K +  L +M  K       
Sbjct: 845  LKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER 904

Query: 128  SEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKML 187
             E L    E L N + E+    G   ++   +   ++LK++D+ E    +   +     L
Sbjct: 905  EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFL 964

Query: 188  EHALRDAKM-AETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQE 246
            + ++ D  + AE    +  + ++++ K L+ +++ L++ +     +  E +    R   E
Sbjct: 965  QKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSE 1024

Query: 247  KSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENS 306
                H+E+L  +++     E  +  K  +E  +  L  L ++  ++Q+D        E++
Sbjct: 1025 TKTKHEEILQNLQKTLLDTE--DKLKGAREENSGLLQELEEL--RKQADKAKAAQTAEDA 1080

Query: 307  QELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQN 366
             ++++    +  E+ A         + L+N   ++D  +E N K++ +  K + +L  +N
Sbjct: 1081 MQIMEQMTKEKTETLASLEDTKQTNAKLQN---ELDTLKENNLKNVEELNKSKELLTVEN 1137

Query: 367  RSDKSSCDECKEKKQ 381
            +  +    E +  KQ
Sbjct: 1138 QKMEEFRKEIETLKQ 1152



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 83/407 (20%), Positives = 169/407 (41%), Gaps = 58/407 (14%)

Query: 19   EISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGE 78
            ++   E + KEL++L  +  ++ K +++  +    QL + EE    +  L +  S+ + E
Sbjct: 723  KLQEAEIKVKELEVLQAKCNEQTKVIDNFTS----QLKATEEKLLDLDALRKASSEGKSE 778

Query: 79   LHKRTEIIRSLTKKVKALE-------SNQMECQTALQKTQLQLQEMAQKATHSSLLSEDL 131
            + K  + + +  K++K LE       S        LQ  +L+L  + +  +  S + E L
Sbjct: 779  MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 838

Query: 132  EARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDK-------DIIEAVNHIADCSGKF 184
            E   + L     E S +   +Q   Q     +  K++       D+ +   ++AD   KF
Sbjct: 839  EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 898

Query: 185  KMLEHALRDAKMAETCIVKEKQDYKQKLKAL-------KIEVNKLKEDLNEKTTENNEQR 237
                   R+    E  ++K K+  +  +  +         ++ K+ ++L  K  +  E +
Sbjct: 899  -------REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQ 951

Query: 238  EEIIRLKQEKSCLHDELL-FTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDL 296
             ++ +  +  S L   +   TV+ E+ + E    A  K E    EL        ++ SDL
Sbjct: 952  LKLTKANENASFLQKSIEDMTVKAEQSQQE----AAKKHEEEKKELE-------RKLSDL 1000

Query: 297  Q-FLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLE----NNHPKVDIKREKNQKS 351
            +  +  +    QEL   Y+    E+K   +  +  L +L+    +   K+   RE+N   
Sbjct: 1001 EKKMETSHNQCQELKARYERATSETK---TKHEEILQNLQKTLLDTEDKLKGAREENSGL 1057

Query: 352  LFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSI 398
            L   Q+ E +   + ++DK+   +  E   QI     ++   TL+S+
Sbjct: 1058 L---QELEEL---RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASL 1098



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 57/318 (17%), Positives = 132/318 (41%), Gaps = 48/318 (15%)

Query: 86  IRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNETLSNTLVEL 145
           I   T   +AL+  Q   +  L +  L+  E+A+  +H   + ++L    +     ++EL
Sbjct: 347 ISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLEL 406

Query: 146 SAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEK 205
            A++ QL+       TM++  D++ +E +N +                            
Sbjct: 407 EAKMDQLR-------TMVEAADREKVELLNQL---------------------------- 431

Query: 206 QDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKD 265
           ++ K+K++ L+  V   +E + +   E   + E     + E+S L ++     ++ +R+ 
Sbjct: 432 EEEKRKVEDLQFRVE--EESITKGDLETQTKLEHARIKELEQSLLFEKT--KADKLQREL 487

Query: 266 ELLNIAKSKQERTNSELHNLRQIYVKQQSDL-QFLNFN-----VENSQELIQMYDSKMEE 319
           E   +A   ++    EL     + V++ ++L + L  N     V+ S  L+Q   S  E+
Sbjct: 488 EDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEK 547

Query: 320 SKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEK 379
            +   +     ++ L+ +    +   +K  K+L+   +    L ++N S KS  +   ++
Sbjct: 548 LEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATE---KLSKENESLKSKLEHANKE 604

Query: 380 KQQIDTVFGEKSVITLSS 397
              +  ++  K    ++S
Sbjct: 605 NSDVIALWKSKLETAIAS 622



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 34/154 (22%), Positives = 74/154 (48%), Gaps = 12/154 (7%)

Query: 17   EVEISTIEKQRKELQLLIGE-LKDRDKE---LNDMVAVHQQQLLSWEEDRQKVLTLEERC 72
            E E S +  Q  E++    + +KD D+E   L   +++    L   + + +K   L    
Sbjct: 1189 EEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEK---LRNEV 1245

Query: 73   SKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLE 132
            + L GE        +SL   V+ LES++++ +  ++  +LQL+E  ++ + SS  ++   
Sbjct: 1246 TVLRGE----NASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQA 1301

Query: 133  ARNETLSNTLVE-LSAQVGQLQAREQALTTMIKL 165
              +E    + ++ L++ +  LQ + Q L   +++
Sbjct: 1302 DEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEM 1335


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.126    0.347 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,599,901
Number of Sequences: 37866
Number of extensions: 1140157
Number of successful extensions: 8463
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 236
Number of HSP's successfully gapped in prelim test: 780
Number of HSP's that attempted gapping in prelim test: 4600
Number of HSP's gapped (non-prelim): 2867
length of query: 682
length of database: 18,247,518
effective HSP length: 109
effective length of query: 573
effective length of database: 14,120,124
effective search space: 8090831052
effective search space used: 8090831052
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.