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Search of human proteins with 30181236
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30181236 copine II [Homo sapiens]
(548 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30181236 copine II [Homo sapiens] 1120 0.0
gi|4503015 copine III [Homo sapiens] 724 0.0
gi|23397708 copine I isoform a [Homo sapiens] 660 0.0
gi|23397706 copine I isoform a [Homo sapiens] 660 0.0
gi|23397704 copine I isoform a [Homo sapiens] 660 0.0
gi|23397702 copine I isoform a [Homo sapiens] 660 0.0
gi|23397700 copine I isoform a [Homo sapiens] 660 0.0
gi|23397698 copine I isoform a [Homo sapiens] 660 0.0
gi|23397696 copine I isoform a [Homo sapiens] 660 0.0
gi|197333761 copine I isoform b [Homo sapiens] 660 0.0
gi|25141328 copine 7 isoform a [Homo sapiens] 597 e-171
gi|18677733 copine IV [Homo sapiens] 580 e-166
gi|25121972 copine VIII [Homo sapiens] 545 e-155
gi|5174421 copine 6 [Homo sapiens] 544 e-155
gi|25141323 copine V [Homo sapiens] 529 e-150
gi|88703066 copine-like protein [Homo sapiens] 511 e-145
gi|7656993 copine 7 isoform b [Homo sapiens] 502 e-142
gi|122937514 unc-13 homolog C [Homo sapiens] 54 5e-07
gi|211059429 synaptotagmin II [Homo sapiens] 53 6e-07
gi|31543670 synaptotagmin II [Homo sapiens] 53 6e-07
gi|209447073 synaptotagmin I [Homo sapiens] 53 8e-07
gi|5032139 synaptotagmin I [Homo sapiens] 53 8e-07
gi|209447070 synaptotagmin I [Homo sapiens] 53 8e-07
gi|4759026 RAS protein activator like 1 [Homo sapiens] 53 8e-07
gi|13384594 protein kinase C, gamma [Homo sapiens] 49 2e-05
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 48 2e-05
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 48 2e-05
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens] 48 2e-05
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 48 2e-05
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 48 2e-05
>gi|30181236 copine II [Homo sapiens]
Length = 548
Score = 1120 bits (2897), Expect = 0.0
Identities = 548/548 (100%), Positives = 548/548 (100%)
Query: 1 MAHIPSGGAPAAGAAPMGPQYCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIE 60
MAHIPSGGAPAAGAAPMGPQYCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIE
Sbjct: 1 MAHIPSGGAPAAGAAPMGPQYCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIE 60
Query: 61 YDRTETAINNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGT 120
YDRTETAINNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGT
Sbjct: 61 YDRTETAINNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGT 120
Query: 121 IVSSKKITRPLLLLNDKPAGKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLE 180
IVSSKKITRPLLLLNDKPAGKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLE
Sbjct: 121 IVSSKKITRPLLLLNDKPAGKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLE 180
Query: 181 FYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHD 240
FYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHD
Sbjct: 181 FYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHD 240
Query: 241 FIGEFQTSVSQMCEARDSVPLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYI 300
FIGEFQTSVSQMCEARDSVPLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYI
Sbjct: 241 FIGEFQTSVSQMCEARDSVPLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYI 300
Query: 301 LGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPA 360
LGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPA
Sbjct: 301 LGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPA 360
Query: 361 LGFGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHV 420
LGFGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHV
Sbjct: 361 LGFGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHV 420
Query: 421 ARFAAQATQQRTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAM 480
ARFAAQATQQRTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAM
Sbjct: 421 ARFAAQATQQRTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAM 480
Query: 481 EFLDGDSRMLRSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNL 540
EFLDGDSRMLRSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNL
Sbjct: 481 EFLDGDSRMLRSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNL 540
Query: 541 PPTNSEPA 548
PPTNSEPA
Sbjct: 541 PPTNSEPA 548
>gi|4503015 copine III [Homo sapiens]
Length = 537
Score = 724 bits (1870), Expect = 0.0
Identities = 340/525 (64%), Positives = 425/525 (80%), Gaps = 2/525 (0%)
Query: 22 CVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGR-WIEYDRTETAINNLNPAFSKKFV 80
CV KV L+VS NLLD+D+ SKSDP CVLF +G+ W E +RTE N LNP FSK F+
Sbjct: 5 CVTKVALNVSCANLLDKDIGSKSDPLCVLFLNTSGQQWYEVERTERIKNCLNPQFSKTFI 64
Query: 81 LDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPAG 140
+DY+FE VQKLKF ++D D ++ L + DFLG+ C+LG IVSSKK+TRPL++ +PAG
Sbjct: 65 IDYYFEVVQKLKFGVYDIDNKTIELSDDDFLGECECTLGQIVSSKKLTRPLVMKTGRPAG 124
Query: 141 KGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIK 200
KG ITI+A+E+ DNRV+ + R+LD KDLFGKSDP+LEF+K DG W++VHRTEV+K
Sbjct: 125 KGSITISAEEIKDNRVVLFEMEARKLDNKDLFGKSDPYLEFHKQTSDGNWLMVHRTEVVK 184
Query: 201 YTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSVP 260
L+PVW+PF + L SLC GDM+K I+V CYDYDNDG HD IG FQT+++++ EA S P
Sbjct: 185 NNLNPVWRPFKISLNSLCYGDMDKTIKVECYDYDNDGSHDLIGTFQTTMTKLKEASRSSP 244
Query: 261 LEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNGN 320
+EFECIN KK++KKK+YKNSG+I ++ C+I + +FLDYI+GGCQL FTVG+DFT SNG+
Sbjct: 245 VEFECINEKKRQKKKSYKNSGVISVKQCEITVECTFLDYIMGGCQLNFTVGVDFTGSNGD 304
Query: 321 PLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAIN 380
P P SLHYI+P G NEYL+A+W+VG +IQDYD+DKMFPA GFGAQ+PP W+VSHEF +N
Sbjct: 305 PRSPDSLHYISPNGVNEYLTALWSVGLVIQDYDADKMFPAFGFGAQIPPQWQVSHEFPMN 364
Query: 381 FNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFILL 440
FNP+NP+C+G+ GI +AY +CLP I+ YGPTNFSPI+NHVARFAA ATQQ+TA+QYF+LL
Sbjct: 365 FNPSNPYCNGIQGIVEAYRSCLPQIKLYGPTNFSPIINHVARFAAAATQQQTASQYFVLL 424
Query: 441 IITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAAR 500
IITDGVI+D++ETR A+V AS+LPMSIIIVGVG ADF+AMEFLDGD LRS GE A R
Sbjct: 425 IITDGVITDLDETRQAIVNASRLPMSIIIVGVGGADFSAMEFLDGDGGSLRSPLGEVAIR 484
Query: 501 DIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFK-HKNLPPTN 544
DIVQFVPFR+F+NA KE LA+ VLAE+PQQVV YF +K LPP N
Sbjct: 485 DIVQFVPFRQFQNAPKEALAQCVLAEIPQQVVGYFNTYKLLPPKN 529
>gi|23397708 copine I isoform a [Homo sapiens]
Length = 537
Score = 660 bits (1703), Expect = 0.0
Identities = 313/535 (58%), Positives = 402/535 (75%), Gaps = 12/535 (2%)
Query: 21 YCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTE-NNGRWIEYDRTETAINNLNPAFSKKF 79
+CV V+LS+S +L+D+D+ SKSDP CVL + G W E RTE N +P FSK
Sbjct: 3 HCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTL 62
Query: 80 VLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPA 139
L+Y FE VQKL+F ++D D + L + DFLG CSLG IVSS+ +T PL+L KPA
Sbjct: 63 QLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPA 122
Query: 140 GKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVI 199
G+G IT++AQEL DNRV+T+ + R LDKKD GKSDPFLEF++ GD GKW LV+R+EVI
Sbjct: 123 GRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 181
Query: 200 KYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSV 259
K L+P WK F+VP+ C G+ PIQV C DYD+DG HD IG F TS++Q+ +V
Sbjct: 182 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQL----QAV 237
Query: 260 PLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNG 319
P EFECI+P+KQ+KKK+YKNSG I ++ C++ +YSFLDY++GGCQ+ FTVG+DFT SNG
Sbjct: 238 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 320 NPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAI 379
+P P SLHY++P G NEYL A+W+VG ++QDYDSDK+FPA GFGAQ+PPDW+VSHEFA+
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 380 NFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFIL 439
NFNP+NP+C+G+ GI AY LP +R YGPTNF+PI+NHVARFAAQA Q TA+QYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 440 LIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAA 499
L++TDG ++D+E TR AVV+AS LPMS+IIVGVG ADF AME LD D L + +G+ AA
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 500 RDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKH------KNLPPTNSEPA 548
RDIVQFVP+R F+NA +E LA+ VLAE+P Q+V YF+ K LPP+ +PA
Sbjct: 478 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDPA 532
>gi|23397706 copine I isoform a [Homo sapiens]
Length = 537
Score = 660 bits (1703), Expect = 0.0
Identities = 313/535 (58%), Positives = 402/535 (75%), Gaps = 12/535 (2%)
Query: 21 YCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTE-NNGRWIEYDRTETAINNLNPAFSKKF 79
+CV V+LS+S +L+D+D+ SKSDP CVL + G W E RTE N +P FSK
Sbjct: 3 HCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTL 62
Query: 80 VLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPA 139
L+Y FE VQKL+F ++D D + L + DFLG CSLG IVSS+ +T PL+L KPA
Sbjct: 63 QLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPA 122
Query: 140 GKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVI 199
G+G IT++AQEL DNRV+T+ + R LDKKD GKSDPFLEF++ GD GKW LV+R+EVI
Sbjct: 123 GRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 181
Query: 200 KYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSV 259
K L+P WK F+VP+ C G+ PIQV C DYD+DG HD IG F TS++Q+ +V
Sbjct: 182 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQL----QAV 237
Query: 260 PLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNG 319
P EFECI+P+KQ+KKK+YKNSG I ++ C++ +YSFLDY++GGCQ+ FTVG+DFT SNG
Sbjct: 238 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 320 NPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAI 379
+P P SLHY++P G NEYL A+W+VG ++QDYDSDK+FPA GFGAQ+PPDW+VSHEFA+
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 380 NFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFIL 439
NFNP+NP+C+G+ GI AY LP +R YGPTNF+PI+NHVARFAAQA Q TA+QYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 440 LIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAA 499
L++TDG ++D+E TR AVV+AS LPMS+IIVGVG ADF AME LD D L + +G+ AA
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 500 RDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKH------KNLPPTNSEPA 548
RDIVQFVP+R F+NA +E LA+ VLAE+P Q+V YF+ K LPP+ +PA
Sbjct: 478 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDPA 532
>gi|23397704 copine I isoform a [Homo sapiens]
Length = 537
Score = 660 bits (1703), Expect = 0.0
Identities = 313/535 (58%), Positives = 402/535 (75%), Gaps = 12/535 (2%)
Query: 21 YCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTE-NNGRWIEYDRTETAINNLNPAFSKKF 79
+CV V+LS+S +L+D+D+ SKSDP CVL + G W E RTE N +P FSK
Sbjct: 3 HCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTL 62
Query: 80 VLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPA 139
L+Y FE VQKL+F ++D D + L + DFLG CSLG IVSS+ +T PL+L KPA
Sbjct: 63 QLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPA 122
Query: 140 GKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVI 199
G+G IT++AQEL DNRV+T+ + R LDKKD GKSDPFLEF++ GD GKW LV+R+EVI
Sbjct: 123 GRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 181
Query: 200 KYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSV 259
K L+P WK F+VP+ C G+ PIQV C DYD+DG HD IG F TS++Q+ +V
Sbjct: 182 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQL----QAV 237
Query: 260 PLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNG 319
P EFECI+P+KQ+KKK+YKNSG I ++ C++ +YSFLDY++GGCQ+ FTVG+DFT SNG
Sbjct: 238 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 320 NPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAI 379
+P P SLHY++P G NEYL A+W+VG ++QDYDSDK+FPA GFGAQ+PPDW+VSHEFA+
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 380 NFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFIL 439
NFNP+NP+C+G+ GI AY LP +R YGPTNF+PI+NHVARFAAQA Q TA+QYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 440 LIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAA 499
L++TDG ++D+E TR AVV+AS LPMS+IIVGVG ADF AME LD D L + +G+ AA
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 500 RDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKH------KNLPPTNSEPA 548
RDIVQFVP+R F+NA +E LA+ VLAE+P Q+V YF+ K LPP+ +PA
Sbjct: 478 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDPA 532
>gi|23397702 copine I isoform a [Homo sapiens]
Length = 537
Score = 660 bits (1703), Expect = 0.0
Identities = 313/535 (58%), Positives = 402/535 (75%), Gaps = 12/535 (2%)
Query: 21 YCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTE-NNGRWIEYDRTETAINNLNPAFSKKF 79
+CV V+LS+S +L+D+D+ SKSDP CVL + G W E RTE N +P FSK
Sbjct: 3 HCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTL 62
Query: 80 VLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPA 139
L+Y FE VQKL+F ++D D + L + DFLG CSLG IVSS+ +T PL+L KPA
Sbjct: 63 QLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPA 122
Query: 140 GKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVI 199
G+G IT++AQEL DNRV+T+ + R LDKKD GKSDPFLEF++ GD GKW LV+R+EVI
Sbjct: 123 GRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 181
Query: 200 KYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSV 259
K L+P WK F+VP+ C G+ PIQV C DYD+DG HD IG F TS++Q+ +V
Sbjct: 182 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQL----QAV 237
Query: 260 PLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNG 319
P EFECI+P+KQ+KKK+YKNSG I ++ C++ +YSFLDY++GGCQ+ FTVG+DFT SNG
Sbjct: 238 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 320 NPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAI 379
+P P SLHY++P G NEYL A+W+VG ++QDYDSDK+FPA GFGAQ+PPDW+VSHEFA+
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 380 NFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFIL 439
NFNP+NP+C+G+ GI AY LP +R YGPTNF+PI+NHVARFAAQA Q TA+QYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 440 LIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAA 499
L++TDG ++D+E TR AVV+AS LPMS+IIVGVG ADF AME LD D L + +G+ AA
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 500 RDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKH------KNLPPTNSEPA 548
RDIVQFVP+R F+NA +E LA+ VLAE+P Q+V YF+ K LPP+ +PA
Sbjct: 478 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDPA 532
>gi|23397700 copine I isoform a [Homo sapiens]
Length = 537
Score = 660 bits (1703), Expect = 0.0
Identities = 313/535 (58%), Positives = 402/535 (75%), Gaps = 12/535 (2%)
Query: 21 YCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTE-NNGRWIEYDRTETAINNLNPAFSKKF 79
+CV V+LS+S +L+D+D+ SKSDP CVL + G W E RTE N +P FSK
Sbjct: 3 HCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTL 62
Query: 80 VLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPA 139
L+Y FE VQKL+F ++D D + L + DFLG CSLG IVSS+ +T PL+L KPA
Sbjct: 63 QLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPA 122
Query: 140 GKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVI 199
G+G IT++AQEL DNRV+T+ + R LDKKD GKSDPFLEF++ GD GKW LV+R+EVI
Sbjct: 123 GRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 181
Query: 200 KYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSV 259
K L+P WK F+VP+ C G+ PIQV C DYD+DG HD IG F TS++Q+ +V
Sbjct: 182 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQL----QAV 237
Query: 260 PLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNG 319
P EFECI+P+KQ+KKK+YKNSG I ++ C++ +YSFLDY++GGCQ+ FTVG+DFT SNG
Sbjct: 238 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 320 NPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAI 379
+P P SLHY++P G NEYL A+W+VG ++QDYDSDK+FPA GFGAQ+PPDW+VSHEFA+
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 380 NFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFIL 439
NFNP+NP+C+G+ GI AY LP +R YGPTNF+PI+NHVARFAAQA Q TA+QYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 440 LIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAA 499
L++TDG ++D+E TR AVV+AS LPMS+IIVGVG ADF AME LD D L + +G+ AA
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 500 RDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKH------KNLPPTNSEPA 548
RDIVQFVP+R F+NA +E LA+ VLAE+P Q+V YF+ K LPP+ +PA
Sbjct: 478 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDPA 532
>gi|23397698 copine I isoform a [Homo sapiens]
Length = 537
Score = 660 bits (1703), Expect = 0.0
Identities = 313/535 (58%), Positives = 402/535 (75%), Gaps = 12/535 (2%)
Query: 21 YCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTE-NNGRWIEYDRTETAINNLNPAFSKKF 79
+CV V+LS+S +L+D+D+ SKSDP CVL + G W E RTE N +P FSK
Sbjct: 3 HCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTL 62
Query: 80 VLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPA 139
L+Y FE VQKL+F ++D D + L + DFLG CSLG IVSS+ +T PL+L KPA
Sbjct: 63 QLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPA 122
Query: 140 GKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVI 199
G+G IT++AQEL DNRV+T+ + R LDKKD GKSDPFLEF++ GD GKW LV+R+EVI
Sbjct: 123 GRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 181
Query: 200 KYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSV 259
K L+P WK F+VP+ C G+ PIQV C DYD+DG HD IG F TS++Q+ +V
Sbjct: 182 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQL----QAV 237
Query: 260 PLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNG 319
P EFECI+P+KQ+KKK+YKNSG I ++ C++ +YSFLDY++GGCQ+ FTVG+DFT SNG
Sbjct: 238 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 320 NPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAI 379
+P P SLHY++P G NEYL A+W+VG ++QDYDSDK+FPA GFGAQ+PPDW+VSHEFA+
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 380 NFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFIL 439
NFNP+NP+C+G+ GI AY LP +R YGPTNF+PI+NHVARFAAQA Q TA+QYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 440 LIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAA 499
L++TDG ++D+E TR AVV+AS LPMS+IIVGVG ADF AME LD D L + +G+ AA
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 500 RDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKH------KNLPPTNSEPA 548
RDIVQFVP+R F+NA +E LA+ VLAE+P Q+V YF+ K LPP+ +PA
Sbjct: 478 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDPA 532
>gi|23397696 copine I isoform a [Homo sapiens]
Length = 537
Score = 660 bits (1703), Expect = 0.0
Identities = 313/535 (58%), Positives = 402/535 (75%), Gaps = 12/535 (2%)
Query: 21 YCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTE-NNGRWIEYDRTETAINNLNPAFSKKF 79
+CV V+LS+S +L+D+D+ SKSDP CVL + G W E RTE N +P FSK
Sbjct: 3 HCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTL 62
Query: 80 VLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPA 139
L+Y FE VQKL+F ++D D + L + DFLG CSLG IVSS+ +T PL+L KPA
Sbjct: 63 QLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPA 122
Query: 140 GKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVI 199
G+G IT++AQEL DNRV+T+ + R LDKKD GKSDPFLEF++ GD GKW LV+R+EVI
Sbjct: 123 GRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 181
Query: 200 KYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSV 259
K L+P WK F+VP+ C G+ PIQV C DYD+DG HD IG F TS++Q+ +V
Sbjct: 182 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQL----QAV 237
Query: 260 PLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNG 319
P EFECI+P+KQ+KKK+YKNSG I ++ C++ +YSFLDY++GGCQ+ FTVG+DFT SNG
Sbjct: 238 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 320 NPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAI 379
+P P SLHY++P G NEYL A+W+VG ++QDYDSDK+FPA GFGAQ+PPDW+VSHEFA+
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 380 NFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFIL 439
NFNP+NP+C+G+ GI AY LP +R YGPTNF+PI+NHVARFAAQA Q TA+QYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 440 LIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAA 499
L++TDG ++D+E TR AVV+AS LPMS+IIVGVG ADF AME LD D L + +G+ AA
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 500 RDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKH------KNLPPTNSEPA 548
RDIVQFVP+R F+NA +E LA+ VLAE+P Q+V YF+ K LPP+ +PA
Sbjct: 478 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDPA 532
>gi|197333761 copine I isoform b [Homo sapiens]
Length = 542
Score = 660 bits (1703), Expect = 0.0
Identities = 313/535 (58%), Positives = 402/535 (75%), Gaps = 12/535 (2%)
Query: 21 YCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTE-NNGRWIEYDRTETAINNLNPAFSKKF 79
+CV V+LS+S +L+D+D+ SKSDP CVL + G W E RTE N +P FSK
Sbjct: 8 HCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTL 67
Query: 80 VLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPA 139
L+Y FE VQKL+F ++D D + L + DFLG CSLG IVSS+ +T PL+L KPA
Sbjct: 68 QLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPA 127
Query: 140 GKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVI 199
G+G IT++AQEL DNRV+T+ + R LDKKD GKSDPFLEF++ GD GKW LV+R+EVI
Sbjct: 128 GRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGD-GKWHLVYRSEVI 186
Query: 200 KYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSV 259
K L+P WK F+VP+ C G+ PIQV C DYD+DG HD IG F TS++Q+ +V
Sbjct: 187 KNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQL----QAV 242
Query: 260 PLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNG 319
P EFECI+P+KQ+KKK+YKNSG I ++ C++ +YSFLDY++GGCQ+ FTVG+DFT SNG
Sbjct: 243 PAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 302
Query: 320 NPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAI 379
+P P SLHY++P G NEYL A+W+VG ++QDYDSDK+FPA GFGAQ+PPDW+VSHEFA+
Sbjct: 303 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 362
Query: 380 NFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFIL 439
NFNP+NP+C+G+ GI AY LP +R YGPTNF+PI+NHVARFAAQA Q TA+QYF+L
Sbjct: 363 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 422
Query: 440 LIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAA 499
L++TDG ++D+E TR AVV+AS LPMS+IIVGVG ADF AME LD D L + +G+ AA
Sbjct: 423 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 482
Query: 500 RDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKH------KNLPPTNSEPA 548
RDIVQFVP+R F+NA +E LA+ VLAE+P Q+V YF+ K LPP+ +PA
Sbjct: 483 RDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDPA 537
>gi|25141328 copine 7 isoform a [Homo sapiens]
Length = 558
Score = 597 bits (1540), Expect = e-171
Identities = 292/540 (54%), Positives = 388/540 (71%), Gaps = 3/540 (0%)
Query: 6 SGGAPAAGAAPMG-PQYCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRT 64
+G A A P G P C KVEL +S ++LLDRD +KSDP L + G+W++ RT
Sbjct: 3 AGSERGAAATPGGLPAPCASKVELRLSCRHLLDRDPLTKSDPSVALLQQAQGQWVQVGRT 62
Query: 65 ETAINNLNPAFSKKFVLDYHFEEVQKLKFALFD-QDKSSMRLDEHDFLGQFSCSLGTIVS 123
E ++L+P FSK F +DY+FEEVQ+L+F ++D S E DFLG C+LG IV+
Sbjct: 63 EVVRSSLHPVFSKVFTVDYYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLGQIVA 122
Query: 124 SKKITRPLLLLNDKPAGKGLITIAAQELSDNR-VITLSLAGRRLDKKDLFGKSDPFLEFY 182
KK+TRPLLL + AGK IT+ A+++S N + LS R+LD KDLF KSDPFLE Y
Sbjct: 123 QKKVTRPLLLKFGRNAGKSTITVIAEDISGNNGYVELSFRARKLDDKDLFSKSDPFLELY 182
Query: 183 KPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFI 242
+ DD LV+RTEV+K L+PVW+ F V L SLC + +P++ + +DYD+ G HDFI
Sbjct: 183 RVNDDQGLQLVYRTEVVKNNLNPVWEAFKVSLSSLCSCEETRPLKCLVWDYDSRGKHDFI 242
Query: 243 GEFQTSVSQMCEARDSVPLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILG 302
GEF T+ +M +A + +++C+NPK ++K+++YKNSG+++L K +R YSFLDYI+G
Sbjct: 243 GEFSTTFEEMQKAFEEGQAQWDCVNPKYKQKRRSYKNSGVVVLADLKFHRVYSFLDYIMG 302
Query: 303 GCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALG 362
GCQ+ FTV IDFTASNG+P + SLHYINP NEYL A+ +VG+I QDYDSDK F ALG
Sbjct: 303 GCQIHFTVAIDFTASNGDPRNSCSLHYINPYQPNEYLKALVSVGEICQDYDSDKRFSALG 362
Query: 363 FGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVAR 422
FGA++PP ++VSH+FAINFNP + C G+ G+ +AY CLP ++ YGPTN +PI++ VAR
Sbjct: 363 FGARIPPKYEVSHDFAINFNPEDDECEGIQGVVEAYQNCLPRVQLYGPTNVAPIISKVAR 422
Query: 423 FAAQATQQRTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEF 482
AA A+QY+ILLI+TDGV++DM +TR A+V+AS+LPMSIIIVGVGNADF M+
Sbjct: 423 VAAAEESTGKASQYYILLILTDGVVTDMADTREAIVRASRLPMSIIIVGVGNADFTDMQV 482
Query: 483 LDGDSRMLRSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPP 542
LDGD +LRS GE A RDIVQFVPFRE +NA+ LAK VLAE+P+QVV+Y+ H+ LPP
Sbjct: 483 LDGDDGVLRSPRGEPALRDIVQFVPFRELKNASPAALAKCVLAEVPKQVVEYYSHRGLPP 542
>gi|18677733 copine IV [Homo sapiens]
Length = 557
Score = 580 bits (1496), Expect = e-166
Identities = 281/522 (53%), Positives = 376/522 (72%), Gaps = 2/522 (0%)
Query: 22 CVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVL 81
C+ KVEL V+ + + DRD SK DP +L +++G+W E DRTE +NP +SK F +
Sbjct: 22 CLTKVELRVACKGISDRDALSKPDPCVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFTV 81
Query: 82 DYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPAGK 141
D++FEEVQ+L+F + D + L E DFLG C+LG IVS +K+++ LL + AGK
Sbjct: 82 DFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSLLK-HGNTAGK 140
Query: 142 GLITIAAQELSDNR-VITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIK 200
IT+ A+ELS N + L+ R+LD KD F KSDPFLE ++ DD LVHRTEV+
Sbjct: 141 SSITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVVM 200
Query: 201 YTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSVP 260
L P WK F V + SLC GD ++ ++ + +D+D++G HDFIGEF ++ +M A +
Sbjct: 201 NNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAMEGKQ 260
Query: 261 LEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNGN 320
+++ECINPK + KKKNYKNSG +IL CKI++ +SFLDYI+GGCQ+ FTV IDFTASNG+
Sbjct: 261 VQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNGD 320
Query: 321 PLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAIN 380
P + SLHYI+P NEYL A+ AVG+I QDYDSDKMFPA GFGA++PP++ VSH+FAIN
Sbjct: 321 PRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAIN 380
Query: 381 FNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFILL 440
FN NP C+G+ G+ +AY +CLP ++ YGPTN +PI+ VA+ A++ T + A+QYFILL
Sbjct: 381 FNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFILL 440
Query: 441 IITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAAR 500
I+TDGVI+DM +TR A+V AS LPMS+IIVGVGNADF+ M+ LDGD +LRS GE R
Sbjct: 441 ILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVLR 500
Query: 501 DIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPP 542
DIVQFVPFR F++A+ LAK+VLAE+P QVV Y+ K + P
Sbjct: 501 DIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKP 542
>gi|25121972 copine VIII [Homo sapiens]
Length = 564
Score = 545 bits (1405), Expect = e-155
Identities = 275/534 (51%), Positives = 373/534 (69%), Gaps = 18/534 (3%)
Query: 25 KVELSVSGQNLLDRDVTSKSDPFCVLFTEN--NGRWIEYDRTETAINNLNPAFSKKFVLD 82
+VE+SVS +NLLDRD SKSDP CVL+ + N W E+ RTE N LNP F +KF+LD
Sbjct: 25 RVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFILD 84
Query: 83 YHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSK--KITRPLLLLNDKPAG 140
Y FEE + L+F L+D D S L +HDFLGQ C+LG IV S+ ++ +P++ + K G
Sbjct: 85 YFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKKCG 144
Query: 141 KGLITIAAQELSDNR-VITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVI 199
++T A+EL+ R + + +LDKKD FGKSDPFL FY+ +DG + + H+TEV+
Sbjct: 145 TIILT--AEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVV 202
Query: 200 KYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSV 259
K TL+PVW+ F + + +LC+GD ++ I+V YD+D DG HDFIGEF TS ++ +
Sbjct: 203 KNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQF 262
Query: 260 PLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNG 319
+ +E +NPKK+ KKK Y NSG + L S + + SFLDYI GG Q+ FTV IDFTASNG
Sbjct: 263 NV-YEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTASNG 321
Query: 320 NPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAI 379
NP P+SLHY+NP N Y A+ AVG+I+QDYDSDKMFPALGFGA+LPPD ++SHEFA+
Sbjct: 322 NPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHEFAL 381
Query: 380 NFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFIL 439
N NP NP+C G++G+ +AY L ++ YGPTNF+P++NHVAR+A+ + +QYF+L
Sbjct: 382 NGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYASSV---KDGSQYFVL 438
Query: 440 LIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAA 499
LI+TDGVISDM +T+ ++V ASKLPMSIIIVGVG A+F AM LDGD + S G+ A
Sbjct: 439 LIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRVSSR-GKYAE 497
Query: 500 RDIVQFVPFREFRN------AAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEP 547
RDIVQFVPFR++ + + LAK VLAE+P+Q + Y + + + P+ + P
Sbjct: 498 RDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKPSPAPP 551
>gi|5174421 copine 6 [Homo sapiens]
Length = 557
Score = 544 bits (1402), Expect = e-155
Identities = 275/543 (50%), Positives = 365/543 (67%), Gaps = 5/543 (0%)
Query: 10 PAAGAAPMGPQYCV--CKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETA 67
P G P P + +VEL VS LLDRD +K P +L ++ +W+E +RTE
Sbjct: 4 PEMGWVPEPPTMTLGASRVELRVSCHGLLDRDTLTKPHPCVLLKLYSDEQWVEVERTEVL 63
Query: 68 INNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKI 127
+ +P FS+ L+Y FEE Q L+F +FD + + FLG C+LG IVS K+
Sbjct: 64 RSCSSPVFSRVLALEYFFEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKV 123
Query: 128 TRPLLLLNDKPAGKGLITIAAQELSD-NRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGD 186
T+PLLL N K AGK ITI A+E+S N + L+ +LD KDLF KSDPF+E YK +
Sbjct: 124 TKPLLLKNGKTAGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNE 183
Query: 187 DGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQ 246
D LV RTEV+K L+P W+PF + L SLC D+ +P++ + YDYD+ G HDFIGEF
Sbjct: 184 DQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFT 243
Query: 247 TSVSQMCE--ARDSVPLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGC 304
++ +M E A ++++CINPK + KKKNYK+SG ++L C + + ++FLDYI+GGC
Sbjct: 244 STFQEMQEGTANPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGC 303
Query: 305 QLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFG 364
Q+ FTV IDFTASNG+P SLH ++P N YL A+ AVG I QDYDSDK FPA GFG
Sbjct: 304 QISFTVAIDFTASNGDPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFG 363
Query: 365 AQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFA 424
A++PP+++VSH+FAINF+P NP C + G+ +Y CLP I+ YGPTN +PI+N VA A
Sbjct: 364 ARIPPNFEVSHDFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPA 423
Query: 425 AQATQQRTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLD 484
+ AT+Y +LL++TDGV+SDM ETR A+V+AS+LPMSIIIVGVGNADF+ M LD
Sbjct: 424 QREQSTGQATKYSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLD 483
Query: 485 GDSRMLRSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPPTN 544
GD LR G AARDIVQFVPFR+F++AA LAK VLAE+P+QVV+Y+ + + P
Sbjct: 484 GDDGPLRCPRGVPAARDIVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISPGA 543
Query: 545 SEP 547
P
Sbjct: 544 PRP 546
>gi|25141323 copine V [Homo sapiens]
Length = 593
Score = 529 bits (1362), Expect = e-150
Identities = 283/547 (51%), Positives = 373/547 (68%), Gaps = 34/547 (6%)
Query: 25 KVELSVSGQNLLDRDVTSKSDPFCVLFTEN--NGRWIEYDRTETAINNLNPAFSKKFVLD 82
KVE++VS +NLLD+D+ SKSDP CV++T+ N +W E+ RTE N LNP F +KF++D
Sbjct: 24 KVEITVSCRNLLDKDMFSKSDPLCVMYTQGMENKQWREFGRTEVIDNTLNPDFVRKFIVD 83
Query: 83 YHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSS--KKITRPLLL----LND 136
Y FEE Q L+F L+D D S L +HDFLGQ C+LG IV S ++ +PL + LN
Sbjct: 84 YFFEEKQNLRFDLYDVDSKSPDLSKHDFLGQAFCTLGEIVGSPGSRLEKPLTIGAFSLNS 143
Query: 137 K-----PA-------GK--GLITIAAQELSDNR-VITLSLAGRRLDKKDLFGKSDPFLEF 181
+ PA GK G I ++A+ELS+ R V T+ +LDKKD FGKSDPFL F
Sbjct: 144 RTGKPMPAVSNGGVPGKKCGTIILSAEELSNCRDVATMQFCANKLDKKDFFGKSDPFLVF 203
Query: 182 YKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDF 241
Y+ +DG + + H+TEV+K TL+PVW+ F++P+ +LC+GD ++ I+V YD+D DG HDF
Sbjct: 204 YRSNEDGTFTICHKTEVMKNTLNPVWQTFSIPVRALCNGDYDRTIKVEVYDWDRDGSHDF 263
Query: 242 IGEFQTSVSQMCEARDSVPLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYIL 301
IGEF TS ++ + + +E +NPKK+ KKK Y NSG + L S + + +FLDYI
Sbjct: 264 IGEFTTSYRELARGQSQFNI-YEVVNPKKKMKKKKYVNSGTVTLLSFAVESECTFLDYIK 322
Query: 302 GGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPAL 361
GG Q+ FTV IDFTASNGNP +SLHY++P N Y A+ AVG+IIQ YDSDKMFPAL
Sbjct: 323 GGTQINFTVAIDFTASNGNPSQSTSLHYMSPYQLNAYALALTAVGEIIQHYDSDKMFPAL 382
Query: 362 GFGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVA 421
GFGA+LPPD +VSHEF +N N NP C G+DGI +AY L ++ YGPTNF+P+V HVA
Sbjct: 383 GFGAKLPPDGRVSHEFPLNGNQENPSCCGIDGILEAYHRSLRTVQLYGPTNFAPVVTHVA 442
Query: 422 RFAAQATQQRTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAME 481
R AA + +QY +LLIITDGVISDM +T+ A+V A+KLPMSIIIVGVG A+F AM
Sbjct: 443 RNAAAV---QDGSQYSVLLIITDGVISDMAQTKEAIVNAAKLPMSIIIVGVGQAEFDAMV 499
Query: 482 FLDGDSRMLRSHTGEEAARDIVQFVPFREFRN------AAKETLAKAVLAELPQQVVQYF 535
LDGD + S G+ A RDIVQFVPFR++ + + LA+ VLAE+P Q+V Y
Sbjct: 500 ELDGDDVRISSR-GKLAERDIVQFVPFRDYVDRTGNHVLSMARLARDVLAEIPDQLVSYM 558
Query: 536 KHKNLPP 542
K + + P
Sbjct: 559 KAQGIRP 565
>gi|88703066 copine-like protein [Homo sapiens]
Length = 553
Score = 511 bits (1316), Expect = e-145
Identities = 262/535 (48%), Positives = 371/535 (69%), Gaps = 18/535 (3%)
Query: 25 KVELSVSGQNLLDRDVTSKSDPFCVLFTENNG--RWIEYDRTETAINNLNPAFSKKFVLD 82
K+E++VS +NLLD D SKSDP VL+T++ W E+ RTE N LNP F +KFVLD
Sbjct: 15 KIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVLD 74
Query: 83 YHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSK--KITRPLLLLNDKPAG 140
Y FEE Q L+F +++ D + DFLGQ +LG ++ + ++ R L + K G
Sbjct: 75 YFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKKCG 134
Query: 141 KGLITIAAQELSDNR-VITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVI 199
L+T A+ELS+ R + T+ L +LDKKD FGKSDPFL FY+ +DG + + H+TEV+
Sbjct: 135 TILLT--AEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVV 192
Query: 200 KYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSV 259
K TL+PVW+PF++P+ +LC+GD ++ +++ YD+D DG HDFIGEF TS ++ +A++
Sbjct: 193 KNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQF 252
Query: 260 PLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNG 319
+ +E +NP+K+ KKK Y NSG + L S ++ +++F+DYI GG QL FTV IDFTASNG
Sbjct: 253 TV-YEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTASNG 311
Query: 320 NPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAI 379
NPL P+SLHY++P + Y A+ AVG+IIQDYDSDK+FPA GFGA+LPP+ ++SH+F +
Sbjct: 312 NPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQFPL 371
Query: 380 NFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFIL 439
N N +P C+G++G+ ++Y L ++ YGPT F+P++N VAR AA+ + +QY++L
Sbjct: 372 NNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKISD---GSQYYVL 428
Query: 440 LIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAA 499
LIITDGVISDM +T+ A+V AS LPMSIIIVGVG A F AME LDGD + S G A
Sbjct: 429 LIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVSSR-GRYAE 487
Query: 500 RDIVQFVPFREF------RNAAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEPA 548
RDIVQFVPFR++ + + LAK VLAE+P+Q++ Y + +++ P PA
Sbjct: 488 RDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQPRPPPPA 542
>gi|7656993 copine 7 isoform b [Homo sapiens]
Length = 633
Score = 502 bits (1292), Expect = e-142
Identities = 240/423 (56%), Positives = 317/423 (74%), Gaps = 1/423 (0%)
Query: 121 IVSSKKITRPLLLLNDKPAGKGLITIAAQELSDNR-VITLSLAGRRLDKKDLFGKSDPFL 179
IV+ KK+TRPLLL + AGK IT+ A+++S N + LS R+LD KDLF KSDPFL
Sbjct: 195 IVAQKKVTRPLLLKFGRNAGKSTITVIAEDISGNNGYVELSFRARKLDDKDLFSKSDPFL 254
Query: 180 EFYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGH 239
E Y+ DD LV+RTEV+K L+PVW+ F V L SLC + +P++ + +DYD+ G H
Sbjct: 255 ELYRVNDDQGLQLVYRTEVVKNNLNPVWEAFKVSLSSLCSCEETRPLKCLVWDYDSRGKH 314
Query: 240 DFIGEFQTSVSQMCEARDSVPLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDY 299
DFIGEF T+ +M +A + +++C+NPK ++K+++YKNSG+++L K +R YSFLDY
Sbjct: 315 DFIGEFSTTFEEMQKAFEEGQAQWDCVNPKYKQKRRSYKNSGVVVLADLKFHRVYSFLDY 374
Query: 300 ILGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFP 359
I+GGCQ+ FTV IDFTASNG+P + SLHYINP NEYL A+ +VG+I QDYDSDK F
Sbjct: 375 IMGGCQIHFTVAIDFTASNGDPRNSCSLHYINPYQPNEYLKALVSVGEICQDYDSDKRFS 434
Query: 360 ALGFGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNH 419
ALGFGA++PP ++VSH+FAINFNP + C G+ G+ +AY CLP ++ YGPTN +PI++
Sbjct: 435 ALGFGARIPPKYEVSHDFAINFNPEDDECEGIQGVVEAYQNCLPRVQLYGPTNVAPIISK 494
Query: 420 VARFAAQATQQRTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAA 479
VAR AA A+QY+ILLI+TDGV++DM +TR A+V+AS+LPMSIIIVGVGNADF
Sbjct: 495 VARVAAAEESTGKASQYYILLILTDGVVTDMADTREAIVRASRLPMSIIIVGVGNADFTD 554
Query: 480 MEFLDGDSRMLRSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKN 539
M+ LDGD +LRS GE A RDIVQFVPFRE +NA+ LAK VLAE+P+QVV+Y+ H+
Sbjct: 555 MQVLDGDDGVLRSPRGEPALRDIVQFVPFRELKNASPAALAKCVLAEVPKQVVEYYSHRG 614
Query: 540 LPP 542
LPP
Sbjct: 615 LPP 617
Score = 100 bits (249), Expect = 3e-21
Identities = 52/116 (44%), Positives = 71/116 (61%), Gaps = 2/116 (1%)
Query: 6 SGGAPAAGAAPMG-PQYCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRT 64
+G A A P G P C KVEL +S ++LLDRD +KSDP L + G+W++ RT
Sbjct: 3 AGSERGAAATPGGLPAPCASKVELRLSCRHLLDRDPLTKSDPSVALLQQAQGQWVQVGRT 62
Query: 65 ETAINNLNPAFSKKFVLDYHFEEVQKLKFALFD-QDKSSMRLDEHDFLGQFSCSLG 119
E ++L+P FSK F +DY+FEEVQ+L+F ++D S E DFLG C+LG
Sbjct: 63 EVVRSSLHPVFSKVFTVDYYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLG 118
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/94 (39%), Positives = 51/94 (54%), Gaps = 8/94 (8%)
Query: 26 VELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIE-YDRTETAINNLNP---AFSKKFVL 81
VELS + L D+D+ SKSDPF L+ N+ + ++ RTE NNLNP AF
Sbjct: 232 VELSFRARKLDDKDLFSKSDPFLELYRVNDDQGLQLVYRTEVVKNNLNPVWEAFKVSLSS 291
Query: 82 DYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFS 115
EE + LK ++D D +HDF+G+FS
Sbjct: 292 LCSCEETRPLKCLVWDYDSRG----KHDFIGEFS 321
Score = 37.4 bits (85), Expect = 0.036
Identities = 32/103 (31%), Positives = 50/103 (48%), Gaps = 15/103 (14%)
Query: 157 ITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVW-KPFTVPLV 215
+ L L+ R L +D KSDP + + G+W+ V RTEV++ +L PV+ K FTV
Sbjct: 24 VELRLSCRHLLDRDPLTKSDPSVALLQQAQ-GQWVQVGRTEVVRSSLHPVFSKVFTV--- 79
Query: 216 SLCDGDMEKPIQVMCYDYDNDG-------GHDFIGEFQTSVSQ 251
D E+ ++ YD G DF+G + ++ Q
Sbjct: 80 ---DYYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLGQ 119
>gi|122937514 unc-13 homolog C [Homo sapiens]
Length = 2214
Score = 53.5 bits (127), Expect = 5e-07
Identities = 37/124 (29%), Positives = 55/124 (44%), Gaps = 13/124 (10%)
Query: 30 VSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQ 89
VS Q L +D T SDP+ + N R RT+T NLNP + +KF + H
Sbjct: 1227 VSAQGLQAKDKTGSSDPYVTVQVGKNKR-----RTKTIFGNLNPVWDEKFYFECH-NSTD 1280
Query: 90 KLKFALFDQD-------KSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPAGKG 142
++K ++D+D K + + DFLGQ + T+ + L DK A G
Sbjct: 1281 RIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSG 1340
Query: 143 LITI 146
I +
Sbjct: 1341 AIRL 1344
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 53.1 bits (126), Expect = 6e-07
Identities = 54/215 (25%), Positives = 101/215 (46%), Gaps = 20/215 (9%)
Query: 39 DVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEV--QKLKFALF 96
D+ SDP+ +F + + +Y+ T+ LNPAF++ F ++E+ + L A++
Sbjct: 170 DMGGTSDPYVKVFLLPDKKK-KYE-TKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIY 227
Query: 97 DQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLL---NDKPAGKGLITIAAQELSD 153
D D R +HD +G+ + T+ + I L ++P G I + + +
Sbjct: 228 DFD----RFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPT 283
Query: 154 NRVITLS-LAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWK---P 209
+T+ L + L K D+ G SDP+++ + +GK + +T V K TL+P +
Sbjct: 284 AGKLTVCILEAKNLKKMDVGGLSDPYVKIHLM-QNGKRLKKKKTTVKKKTLNPYFNESFS 342
Query: 210 FTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGE 244
F +P + + + V DYD G ++ IG+
Sbjct: 343 FEIPFEQI----QKVQVVVTVLDYDKLGKNEAIGK 373
Score = 43.9 bits (102), Expect = 4e-04
Identities = 26/87 (29%), Positives = 43/87 (49%), Gaps = 6/87 (6%)
Query: 16 PMGPQYCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAF 75
P + VC +E +NL DV SDP+ + NG+ ++ +T LNP F
Sbjct: 282 PTAGKLTVCILE----AKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYF 337
Query: 76 SKKFVLDYHFEEVQKLK--FALFDQDK 100
++ F + FE++QK++ + D DK
Sbjct: 338 NESFSFEIPFEQIQKVQVVVTVLDYDK 364
Score = 36.2 bits (82), Expect = 0.080
Identities = 28/100 (28%), Positives = 46/100 (46%), Gaps = 10/100 (10%)
Query: 154 NRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKP---F 210
N++ L L D+ G SDP+++ + D K + T+V + TL+P + F
Sbjct: 154 NQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKK---KYETKVHRKTLNPAFNETFTF 210
Query: 211 TVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVS 250
VP L K + + YD+D HD IGE + ++
Sbjct: 211 KVPYQELGG----KTLVMAIYDFDRFSKHDIIGEVKVPMN 246
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 53.1 bits (126), Expect = 6e-07
Identities = 54/215 (25%), Positives = 101/215 (46%), Gaps = 20/215 (9%)
Query: 39 DVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEV--QKLKFALF 96
D+ SDP+ +F + + +Y+ T+ LNPAF++ F ++E+ + L A++
Sbjct: 170 DMGGTSDPYVKVFLLPDKKK-KYE-TKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIY 227
Query: 97 DQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLL---NDKPAGKGLITIAAQELSD 153
D D R +HD +G+ + T+ + I L ++P G I + + +
Sbjct: 228 DFD----RFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPT 283
Query: 154 NRVITLS-LAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWK---P 209
+T+ L + L K D+ G SDP+++ + +GK + +T V K TL+P +
Sbjct: 284 AGKLTVCILEAKNLKKMDVGGLSDPYVKIHLM-QNGKRLKKKKTTVKKKTLNPYFNESFS 342
Query: 210 FTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGE 244
F +P + + + V DYD G ++ IG+
Sbjct: 343 FEIPFEQI----QKVQVVVTVLDYDKLGKNEAIGK 373
Score = 43.9 bits (102), Expect = 4e-04
Identities = 26/87 (29%), Positives = 43/87 (49%), Gaps = 6/87 (6%)
Query: 16 PMGPQYCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAF 75
P + VC +E +NL DV SDP+ + NG+ ++ +T LNP F
Sbjct: 282 PTAGKLTVCILE----AKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYF 337
Query: 76 SKKFVLDYHFEEVQKLK--FALFDQDK 100
++ F + FE++QK++ + D DK
Sbjct: 338 NESFSFEIPFEQIQKVQVVVTVLDYDK 364
Score = 36.2 bits (82), Expect = 0.080
Identities = 28/100 (28%), Positives = 46/100 (46%), Gaps = 10/100 (10%)
Query: 154 NRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKP---F 210
N++ L L D+ G SDP+++ + D K + T+V + TL+P + F
Sbjct: 154 NQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKK---KYETKVHRKTLNPAFNETFTF 210
Query: 211 TVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVS 250
VP L K + + YD+D HD IGE + ++
Sbjct: 211 KVPYQELGG----KTLVMAIYDFDRFSKHDIIGEVKVPMN 246
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 52.8 bits (125), Expect = 8e-07
Identities = 56/218 (25%), Positives = 102/218 (46%), Gaps = 26/218 (11%)
Query: 39 DVTSKSDPFCVLFTENNGRWIEYDRTETAINN--LNPAFSKKFVLDYHFEEV--QKLKFA 94
D+ SDP+ +F + + + ET ++ LNP F+++F + E+ + L A
Sbjct: 173 DMGGTSDPYVKVFLLPDKK----KKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMA 228
Query: 95 LFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKIT---RPLLLLNDKPAGK-GLITIAAQE 150
++D D R +HD +G+F + T V +T R L + K G I + +
Sbjct: 229 VYDFD----RFSKHDIIGEFKVPMNT-VDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRY 283
Query: 151 L-SDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWK- 208
+ + ++ + L + L K D+ G SDP+++ + +GK + +T + K TL+P +
Sbjct: 284 VPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLM-QNGKRLKKKKTTIKKNTLNPYYNE 342
Query: 209 --PFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGE 244
F VP + + + V DYD G +D IG+
Sbjct: 343 SFSFEVPFEQI----QKVQVVVTVLDYDKIGKNDAIGK 376
Score = 43.9 bits (102), Expect = 4e-04
Identities = 24/86 (27%), Positives = 46/86 (53%), Gaps = 6/86 (6%)
Query: 30 VSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQ 89
+ +NL DV SDP+ + NG+ ++ +T N LNP +++ F + FE++Q
Sbjct: 295 LEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQ 354
Query: 90 KLK--FALFDQDKSSMRLDEHDFLGQ 113
K++ + D DK + ++D +G+
Sbjct: 355 KVQVVVTVLDYDK----IGKNDAIGK 376
Score = 40.8 bits (94), Expect = 0.003
Identities = 29/104 (27%), Positives = 50/104 (48%), Gaps = 10/104 (9%)
Query: 150 ELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKP 209
+ +N+++ + L D+ G SDP+++ + D K T+V + TL+PV+
Sbjct: 153 DFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKF---ETKVHRKTLNPVFNE 209
Query: 210 ---FTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVS 250
F VP L K + + YD+D HD IGEF+ ++
Sbjct: 210 QFTFKVPYSELGG----KTLVMAVYDFDRFSKHDIIGEFKVPMN 249
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 52.8 bits (125), Expect = 8e-07
Identities = 56/218 (25%), Positives = 102/218 (46%), Gaps = 26/218 (11%)
Query: 39 DVTSKSDPFCVLFTENNGRWIEYDRTETAINN--LNPAFSKKFVLDYHFEEV--QKLKFA 94
D+ SDP+ +F + + + ET ++ LNP F+++F + E+ + L A
Sbjct: 173 DMGGTSDPYVKVFLLPDKK----KKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMA 228
Query: 95 LFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKIT---RPLLLLNDKPAGK-GLITIAAQE 150
++D D R +HD +G+F + T V +T R L + K G I + +
Sbjct: 229 VYDFD----RFSKHDIIGEFKVPMNT-VDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRY 283
Query: 151 L-SDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWK- 208
+ + ++ + L + L K D+ G SDP+++ + +GK + +T + K TL+P +
Sbjct: 284 VPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLM-QNGKRLKKKKTTIKKNTLNPYYNE 342
Query: 209 --PFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGE 244
F VP + + + V DYD G +D IG+
Sbjct: 343 SFSFEVPFEQI----QKVQVVVTVLDYDKIGKNDAIGK 376
Score = 43.9 bits (102), Expect = 4e-04
Identities = 24/86 (27%), Positives = 46/86 (53%), Gaps = 6/86 (6%)
Query: 30 VSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQ 89
+ +NL DV SDP+ + NG+ ++ +T N LNP +++ F + FE++Q
Sbjct: 295 LEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQ 354
Query: 90 KLK--FALFDQDKSSMRLDEHDFLGQ 113
K++ + D DK + ++D +G+
Sbjct: 355 KVQVVVTVLDYDK----IGKNDAIGK 376
Score = 40.8 bits (94), Expect = 0.003
Identities = 29/104 (27%), Positives = 50/104 (48%), Gaps = 10/104 (9%)
Query: 150 ELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKP 209
+ +N+++ + L D+ G SDP+++ + D K T+V + TL+PV+
Sbjct: 153 DFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKF---ETKVHRKTLNPVFNE 209
Query: 210 ---FTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVS 250
F VP L K + + YD+D HD IGEF+ ++
Sbjct: 210 QFTFKVPYSELGG----KTLVMAVYDFDRFSKHDIIGEFKVPMN 249
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 52.8 bits (125), Expect = 8e-07
Identities = 56/218 (25%), Positives = 102/218 (46%), Gaps = 26/218 (11%)
Query: 39 DVTSKSDPFCVLFTENNGRWIEYDRTETAINN--LNPAFSKKFVLDYHFEEV--QKLKFA 94
D+ SDP+ +F + + + ET ++ LNP F+++F + E+ + L A
Sbjct: 173 DMGGTSDPYVKVFLLPDKK----KKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMA 228
Query: 95 LFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKIT---RPLLLLNDKPAGK-GLITIAAQE 150
++D D R +HD +G+F + T V +T R L + K G I + +
Sbjct: 229 VYDFD----RFSKHDIIGEFKVPMNT-VDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRY 283
Query: 151 L-SDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWK- 208
+ + ++ + L + L K D+ G SDP+++ + +GK + +T + K TL+P +
Sbjct: 284 VPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLM-QNGKRLKKKKTTIKKNTLNPYYNE 342
Query: 209 --PFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGE 244
F VP + + + V DYD G +D IG+
Sbjct: 343 SFSFEVPFEQI----QKVQVVVTVLDYDKIGKNDAIGK 376
Score = 43.9 bits (102), Expect = 4e-04
Identities = 24/86 (27%), Positives = 46/86 (53%), Gaps = 6/86 (6%)
Query: 30 VSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQ 89
+ +NL DV SDP+ + NG+ ++ +T N LNP +++ F + FE++Q
Sbjct: 295 LEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQ 354
Query: 90 KLK--FALFDQDKSSMRLDEHDFLGQ 113
K++ + D DK + ++D +G+
Sbjct: 355 KVQVVVTVLDYDK----IGKNDAIGK 376
Score = 40.8 bits (94), Expect = 0.003
Identities = 29/104 (27%), Positives = 50/104 (48%), Gaps = 10/104 (9%)
Query: 150 ELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKP 209
+ +N+++ + L D+ G SDP+++ + D K T+V + TL+PV+
Sbjct: 153 DFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKF---ETKVHRKTLNPVFNE 209
Query: 210 ---FTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVS 250
F VP L K + + YD+D HD IGEF+ ++
Sbjct: 210 QFTFKVPYSELGG----KTLVMAVYDFDRFSKHDIIGEFKVPMN 249
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 52.8 bits (125), Expect = 8e-07
Identities = 62/229 (27%), Positives = 101/229 (44%), Gaps = 32/229 (13%)
Query: 30 VSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFV----LDYHF 85
V G+ L +DV+ SDP+C++ ++ RT T +L P + +++ LD+H
Sbjct: 12 VEGRALPAKDVSGSSDPYCLVKVDDE----VVARTATVWRSLGPFWGEEYTVHLPLDFH- 66
Query: 86 EEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKK-ITRPLLLLNDKPAG--KG 142
+L F + D+D + D +G+ S S I + + I + L P +G
Sbjct: 67 ----QLAFYVLDED----TVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQG 118
Query: 143 LITIAAQELSDNRVITLS---LAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVI 199
I ++ Q L D + L L R L +D+ G SDPF + G L T I
Sbjct: 119 EICLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFW----GSQSL--ETSTI 172
Query: 200 KYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTS 248
K T P W + L + P++V +D+D G +DF+G + S
Sbjct: 173 KKTRFPHWDE-VLELREM--PGAPSPLRVELWDWDMVGKNDFLGMVEFS 218
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 48.5 bits (114), Expect = 2e-05
Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 3/92 (3%)
Query: 164 RRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDME 223
R L D G SDP+++ K D + + +T +K TL+PVW V +L GD+E
Sbjct: 181 RNLIPMDPNGLSDPYVKL-KLIPDPRNLTKQKTRTVKATLNPVWNETFV--FNLKPGDVE 237
Query: 224 KPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEA 255
+ + V +D+D +DF+G VS++ +A
Sbjct: 238 RRLSVEVWDWDRTSRNDFMGAMSFGVSELLKA 269
Score = 36.6 bits (83), Expect = 0.061
Identities = 24/93 (25%), Positives = 47/93 (50%), Gaps = 5/93 (5%)
Query: 33 QNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQ-KL 91
+NL+ D SDP+ L + R + +T T LNP +++ FV + +V+ +L
Sbjct: 181 RNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRL 240
Query: 92 KFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSS 124
++D D++S +DF+G S + ++ +
Sbjct: 241 SVEVWDWDRTS----RNDFMGAMSFGVSELLKA 269
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/229 (24%), Positives = 93/229 (40%), Gaps = 24/229 (10%)
Query: 30 VSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQ 89
V G+NL +D+T SDP+C++ +N RT T L P + +++ +
Sbjct: 12 VEGKNLPAKDITGSSDPYCIVKVDNE----PIIRTATVWKTLCPFWGEEYQVHLP-PTFH 66
Query: 90 KLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKK---ITRPLLLLNDKPAGKGLITI 146
+ F + D+D L D +G+ + TI S K L ++ +G I +
Sbjct: 67 AVAFYVMDED----ALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHL 122
Query: 147 AAQELSDNRVITLS---LAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTL 203
+ R L L R L KD G SDPF+ G T ++K +
Sbjct: 123 RLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKG------RTRETSIVKKSC 176
Query: 204 DPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQM 252
P W L +G ME + V +D+D +DF+G+ V ++
Sbjct: 177 YPRWNETFE--FELQEGAME-ALCVEAWDWDLVSRNDFLGKVVIDVQRL 222
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/229 (24%), Positives = 93/229 (40%), Gaps = 24/229 (10%)
Query: 30 VSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQ 89
V G+NL +D+T SDP+C++ +N RT T L P + +++ +
Sbjct: 12 VEGKNLPAKDITGSSDPYCIVKVDNE----PIIRTATVWKTLCPFWGEEYQVHLP-PTFH 66
Query: 90 KLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKK---ITRPLLLLNDKPAGKGLITI 146
+ F + D+D L D +G+ + TI S K L ++ +G I +
Sbjct: 67 AVAFYVMDED----ALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHL 122
Query: 147 AAQELSDNRVITLS---LAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTL 203
+ R L L R L KD G SDPF+ G T ++K +
Sbjct: 123 RLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKG------RTRETSIVKKSC 176
Query: 204 DPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQM 252
P W L +G ME + V +D+D +DF+G+ V ++
Sbjct: 177 YPRWNETFE--FELQEGAME-ALCVEAWDWDLVSRNDFLGKVVIDVQRL 222
>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
Length = 1591
Score = 48.1 bits (113), Expect = 2e-05
Identities = 34/124 (27%), Positives = 54/124 (43%), Gaps = 13/124 (10%)
Query: 30 VSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQ 89
V Q L +D T SDP+ + + RT+T NLNP + +KF + H
Sbjct: 607 VCAQGLQAKDKTGSSDPYVTVQVSKTKK-----RTKTIFGNLNPVWEEKFHFECH-NSSD 660
Query: 90 KLKFALFDQD-------KSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPAGKG 142
++K ++D+D K ++ + DFLGQ + T+ + L DK A G
Sbjct: 661 RIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSG 720
Query: 143 LITI 146
I +
Sbjct: 721 AIRL 724
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/229 (24%), Positives = 93/229 (40%), Gaps = 24/229 (10%)
Query: 30 VSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQ 89
V G+NL +D+T SDP+C++ +N RT T L P + +++ +
Sbjct: 12 VEGKNLPAKDITGSSDPYCIVKVDNE----PIIRTATVWKTLCPFWGEEYQVHLP-PTFH 66
Query: 90 KLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKK---ITRPLLLLNDKPAGKGLITI 146
+ F + D+D L D +G+ + TI S K L ++ +G I +
Sbjct: 67 AVAFYVMDED----ALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHL 122
Query: 147 AAQELSDNRVITLS---LAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTL 203
+ R L L R L KD G SDPF+ G T ++K +
Sbjct: 123 RLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKG------RTRETSIVKKSC 176
Query: 204 DPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQM 252
P W L +G ME + V +D+D +DF+G+ V ++
Sbjct: 177 YPRWNETFE--FELQEGAME-ALCVEAWDWDLVSRNDFLGKVVIDVQRL 222
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/229 (24%), Positives = 93/229 (40%), Gaps = 24/229 (10%)
Query: 30 VSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQ 89
V G+NL +D+T SDP+C++ +N RT T L P + +++ +
Sbjct: 12 VEGKNLPAKDITGSSDPYCIVKVDNE----PIIRTATVWKTLCPFWGEEYQVHLP-PTFH 66
Query: 90 KLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKK---ITRPLLLLNDKPAGKGLITI 146
+ F + D+D L D +G+ + TI S K L ++ +G I +
Sbjct: 67 AVAFYVMDED----ALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHL 122
Query: 147 AAQELSDNRVITLS---LAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTL 203
+ R L L R L KD G SDPF+ G T ++K +
Sbjct: 123 RLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKG------RTRETSIVKKSC 176
Query: 204 DPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQM 252
P W L +G ME + V +D+D +DF+G+ V ++
Sbjct: 177 YPRWNETFE--FELQEGAME-ALCVEAWDWDLVSRNDFLGKVVIDVQRL 222
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,304,281
Number of Sequences: 37866
Number of extensions: 946790
Number of successful extensions: 2100
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 1818
Number of HSP's gapped (non-prelim): 230
length of query: 548
length of database: 18,247,518
effective HSP length: 107
effective length of query: 441
effective length of database: 14,195,856
effective search space: 6260372496
effective search space used: 6260372496
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.