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Search of human proteins with 29789451
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29789451 cation channel, sperm associated 3 [Homo sapiens]
(398 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29789451 cation channel, sperm associated 3 [Homo sapiens] 790 0.0
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ... 100 2e-21
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo... 97 3e-20
gi|62988334 cation channel, sperm associated 4 [Homo sapiens] 92 1e-18
gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo s... 87 2e-17
gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo s... 87 2e-17
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 87 2e-17
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H... 87 2e-17
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 86 5e-17
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i... 86 5e-17
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 86 5e-17
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i... 86 5e-17
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i... 86 5e-17
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 86 5e-17
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i... 86 5e-17
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i... 86 5e-17
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I... 86 6e-17
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I... 86 6e-17
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i... 86 8e-17
gi|38505294 voltage-dependent calcium channel alpha 1G subunit i... 86 8e-17
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i... 86 8e-17
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i... 86 8e-17
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i... 86 8e-17
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 86 8e-17
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i... 86 8e-17
gi|237512982 voltage-gated sodium channel type V alpha isoform f... 84 2e-16
gi|237512980 voltage-gated sodium channel type V alpha isoform e... 84 2e-16
gi|37622907 voltage-gated sodium channel type V alpha isoform a ... 84 2e-16
gi|30089970 voltage-gated sodium channel type V alpha isoform b ... 84 2e-16
gi|150417969 voltage-gated sodium channel type V alpha isoform d... 84 2e-16
>gi|29789451 cation channel, sperm associated 3 [Homo sapiens]
Length = 398
Score = 790 bits (2040), Expect = 0.0
Identities = 398/398 (100%), Positives = 398/398 (100%)
Query: 1 MSQHRHQRHSRVISSSPVDTTSVGFCPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTV 60
MSQHRHQRHSRVISSSPVDTTSVGFCPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTV
Sbjct: 1 MSQHRHQRHSRVISSSPVDTTSVGFCPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTV 60
Query: 61 TSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPINYWKNGYNLLDVI 120
TSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPINYWKNGYNLLDVI
Sbjct: 61 TSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPINYWKNGYNLLDVI 120
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV
Sbjct: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
Query: 181 LLLLFLLMYIFAILGFCLFGSPDNGDHDNWGNLAAAFFTLFSLATVDGWTDLQKQLDNRE 240
LLLLFLLMYIFAILGFCLFGSPDNGDHDNWGNLAAAFFTLFSLATVDGWTDLQKQLDNRE
Sbjct: 181 LLLLFLLMYIFAILGFCLFGSPDNGDHDNWGNLAAAFFTLFSLATVDGWTDLQKQLDNRE 240
Query: 241 FALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQEMLMGEKQVILQR 300
FALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQEMLMGEKQVILQR
Sbjct: 241 FALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQEMLMGEKQVILQR 300
Query: 301 QQEEISRLMHIQKNADCTSFSELVENFKKTLSHTDPMVLDDFGTSLPFIDIYFSTLDYQD 360
QQEEISRLMHIQKNADCTSFSELVENFKKTLSHTDPMVLDDFGTSLPFIDIYFSTLDYQD
Sbjct: 301 QQEEISRLMHIQKNADCTSFSELVENFKKTLSHTDPMVLDDFGTSLPFIDIYFSTLDYQD 360
Query: 361 TTVHKLQELYYEIVHVLSLMLEDLPQEKPQSLEKVDEK 398
TTVHKLQELYYEIVHVLSLMLEDLPQEKPQSLEKVDEK
Sbjct: 361 TTVHKLQELYYEIVHVLSLMLEDLPQEKPQSLEKVDEK 398
>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
subunit [Homo sapiens]
Length = 2339
Score = 100 bits (249), Expect = 2e-21
Identities = 66/287 (22%), Positives = 143/287 (49%), Gaps = 16/287 (5%)
Query: 32 FKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFV 91
F+R + R F++R++ ++ F +++ V N +A+ Y+ RL L F+E F+
Sbjct: 464 FRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAM-VHYNQPRRLTTTLYFAEFVFL 522
Query: 92 SICTSELSMKVY-VDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQS 150
+ +E+S+K+Y + P +Y+++ +N D +I+ + + + ++
Sbjct: 523 GLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRL 582
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPDNGDHD-- 208
LRI K+ Y +R L+ ++ ++ ++ S+L LLFL + +FA+LG LFG N +
Sbjct: 583 LRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETP 642
Query: 209 --NWGNLAAAFFTLFSLATVDGWT-----DLQKQLDNREFALSRAFTIIFILLASFIFLN 261
N+ AA T+F + T + W ++ Q + S + I+ L ++ LN
Sbjct: 643 TTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLN 702
Query: 262 MFVGVMIMHTEDSIRKFERELMLEQQEMLMGEKQVILQRQQEEISRL 308
+F+ + + + ++ +EL +++EM Q + ++ +E++ +
Sbjct: 703 VFLAIAVDNLANA-----QELTKDEEEMEEAANQKLALQKAKEVAEV 744
Score = 71.6 bits (174), Expect = 1e-12
Identities = 56/246 (22%), Positives = 113/246 (45%), Gaps = 21/246 (8%)
Query: 47 IMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-D 105
++S F+ +++ + N + + YD Y +L+ I F S+ + E +K+
Sbjct: 1468 VVSPPFEYFIMAMIALNTVVLMM-KFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFG 1526
Query: 106 PINYWKNGYNLLDVIIIIVMFLPYALRQLMG-KQFTYLYIADGMQSLRILKLIGYSQGIR 164
+NY+++ +N+ D + ++ + ++ F L ++ R++KL+ IR
Sbjct: 1527 VLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIR 1586
Query: 165 TLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPDNGD------HDNWGNLAAAFF 218
L+ Q+ + V LL+ +L +I+AI+G +FG+ D H+N+ A
Sbjct: 1587 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALM 1646
Query: 219 TLFSLATVDGWTDLQKQLDNREFALSRA------------FTIIFILLASFIFLNMFVGV 266
LF AT + W ++ + + +A + + FI L SF+ LN+FV V
Sbjct: 1647 LLFRSATGEAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAV 1706
Query: 267 MIMHTE 272
++ + E
Sbjct: 1707 IMDNFE 1712
Score = 65.5 bits (158), Expect = 8e-11
Identities = 77/355 (21%), Positives = 150/355 (42%), Gaps = 72/355 (20%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDI--RYRLFRLLEFSEIFFVSI 93
D+ R + KR+ F+ ++++T+ +N +AL + + L+ +E +F+ I
Sbjct: 81 DNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGI 140
Query: 94 CTSELSMKVYVDPI-----NYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E +K+ +Y +NG+N++D ++++ L A G F L +
Sbjct: 141 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATA-----GTDFD-LRTLRAV 194
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGF----------CL 198
+ LR LKL+ ++ ++ ++ + + + + LLLF + +FAI+G C
Sbjct: 195 RVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACF 254
Query: 199 FGSPD------------------NGDHD-------------NWGNLAAAFFTLFSLATVD 227
S D GD + N+ N+ A T+F T++
Sbjct: 255 PNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITME 314
Query: 228 GWTD-LQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMI---------MHTEDSIRK 277
GWTD L D + + I I++ SF LN+ +GV+ + + K
Sbjct: 315 GWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLK 374
Query: 278 FERELMLEQQ-----EMLMGEKQVIL---QRQQEEISRLMHIQKNADCTSFSELV 324
R+ +E++ E + ++V+L R EE S L +++ A S ++L+
Sbjct: 375 LRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLI 429
Score = 63.9 bits (154), Expect = 2e-10
Identities = 57/297 (19%), Positives = 126/297 (42%), Gaps = 48/297 (16%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
R F ++ R+F+++++ + ++ +A L++ + F + T E+
Sbjct: 1140 RRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMV 1199
Query: 100 MKVY-----VDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRIL 154
+K+ + P Y+++ +N+LD I++ + +A GK + ++ LR L
Sbjct: 1200 IKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPL 1259
Query: 155 KLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGS-----PDNG---- 205
K I ++ + V ++ V ++L++ L M+IFA++ LF D
Sbjct: 1260 KTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELE 1319
Query: 206 --------DHD----------------NWGNLAAAFFTLFSLATVDGWTDLQKQLDNREF 241
D++ ++ N+ A TLF+++T +GW + K + +
Sbjct: 1320 RDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATY 1379
Query: 242 ALS----------RAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQE 288
F +++ ++ F F+N+FV ++I+ ++ K E LE+ E
Sbjct: 1380 EEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNE 1436
>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
sapiens]
Length = 1791
Score = 97.1 bits (240), Expect = 3e-20
Identities = 72/274 (26%), Positives = 142/274 (51%), Gaps = 22/274 (8%)
Query: 30 KKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIF 89
K R ++C+ V ++ S+ F II+IS + N M + SY+ + +L+
Sbjct: 1346 KPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISM-MAESYNQPKAMKSILDHLNWV 1404
Query: 90 FVSICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQF-----TYLYI 144
FV I T E +K++ Y+ NG+NL D +++++ + + L ++ T I
Sbjct: 1405 FVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRI 1464
Query: 145 ADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG--SP 202
+ RIL+L+ ++GIRTL+ A+ ++ ++ ++ LLLFL+M+I+AILG F +P
Sbjct: 1465 VRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNP 1524
Query: 203 DNGDHD--NWGNLAAAFFTLFSLATVDGWTD-LQKQLDNREF-----------ALSRAFT 248
++G D N+ A++ LF ++T GW L L ++E ++ ++
Sbjct: 1525 ESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYF 1584
Query: 249 IIFILLASFIFLNMFVGVMIMHTEDSIRKFEREL 282
+ +I+++ I +NM++ V++ + + + E L
Sbjct: 1585 VSYIIISFLIVVNMYIAVILENFNTATEESEDPL 1618
Score = 72.0 bits (175), Expect = 9e-13
Identities = 53/247 (21%), Positives = 115/247 (46%), Gaps = 26/247 (10%)
Query: 43 VKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKV 102
++ V+ F ++ + + N F+A+ + + ++L + F SI +E+ +K+
Sbjct: 570 LRTVMTDPFTELAITICIIINTVFLAM-EHHKMEASFEKMLNIGNLVFTSIFIAEMCLKI 628
Query: 103 Y-VDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQ 161
+DP +Y++ G+N+ D I+ ++ F L + + +L + LR+ KL
Sbjct: 629 IALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLR---SFRVLRVFKLAKSWP 685
Query: 162 GIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPDNGD--------------- 206
+ TLI +G +V + S+ ++L ++++IF+++G LFG N
Sbjct: 686 TLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSC 745
Query: 207 --HDNWGNLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFIL---LASFIFLN 261
H + G+ +F +F + + W + + A S I+FIL + + LN
Sbjct: 746 LRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLN 804
Query: 262 MFVGVMI 268
+F+ +++
Sbjct: 805 LFIALLL 811
Score = 62.0 bits (149), Expect = 9e-10
Identities = 64/259 (24%), Positives = 111/259 (42%), Gaps = 55/259 (21%)
Query: 78 RLFRLLEFSEIFFVSICTSELSMK-VYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMG 136
++ LL ++I F I E+ +K V Y+ + + LD II+IV L LM
Sbjct: 1085 KIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVT--TLINLME 1142
Query: 137 -KQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILG 195
K F L ++LR L+ + +G++ ++ A+ + + +VLL+ + +F ILG
Sbjct: 1143 LKSFRTL------RALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILG 1196
Query: 196 FCLF----GSPDNGDHD-------------------------NWGNLAAAFFTLFSLATV 226
F G NG N+ N+ A+ L +AT
Sbjct: 1197 VYFFSGKFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATF 1256
Query: 227 DGWTDL----------QKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIR 276
GW D+ ++Q + +L + ++FI+ SF LN+F+GV+I + +
Sbjct: 1257 KGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQK 1316
Query: 277 KFERELMLEQQEMLMGEKQ 295
K L Q++ M E+Q
Sbjct: 1317 K------LGGQDIFMTEEQ 1329
>gi|62988334 cation channel, sperm associated 4 [Homo sapiens]
Length = 472
Score = 91.7 bits (226), Expect = 1e-18
Identities = 60/269 (22%), Positives = 138/269 (51%), Gaps = 16/269 (5%)
Query: 42 FVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMK 101
++K+++ F++++ + NA +AL T+ + + + L + ++I E+ +
Sbjct: 84 YIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLG 143
Query: 102 VYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQ 161
+WK+G+N+L+ II+ ++ L + + ++ Y +++LR++ + +
Sbjct: 144 WLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYT-----LRALRLVHVCMAVE 198
Query: 162 GIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPDNGDHDNWGNLAAAFFTLF 221
+ +I + Q+V +A++++L+ M +F++ G LFG+ ++ N+ A +TLF
Sbjct: 199 PLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGA---FVPKHFQNIQVALYTLF 255
Query: 222 SLATVDGWTDLQK--QLDNREFAL---SRAFTIIFILLASFIFLNMFVGVMIMHTEDSIR 276
T DGW D+ Q + RE+A+ + IFI + +FI +N+FV V+ + E ++
Sbjct: 256 ICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMK 315
Query: 277 KFERELMLEQQEMLMGEKQVILQRQQEEI 305
E+ +QQ + E + + +++
Sbjct: 316 AGEQG---QQQRITFSETGAEEEEENDQL 341
>gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo
sapiens]
Length = 2506
Score = 87.4 bits (215), Expect = 2e-17
Identities = 69/289 (23%), Positives = 139/289 (48%), Gaps = 17/289 (5%)
Query: 32 FKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFV 91
F + + R +++R++ ++ F ++S V N +A+ Y+ L L ++E F+
Sbjct: 468 FHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAI-VHYNQPEWLSDFLYYAEFIFL 526
Query: 92 SICTSELSMKVY-VDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQS 150
+ SE+ +K+Y + Y+ + +N D +II + + + ++
Sbjct: 527 GLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRL 586
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPDNGDH--- 207
LRI K+ Y +R L+ ++ ++ ++ S+L LLFL + +FA+LG LFG N D
Sbjct: 587 LRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP 646
Query: 208 -DNWGNLAAAFFTLFSLATVDGWTDLQKQLDNREFAL--SRAFTIIFILL---ASFIFLN 261
N+ AA T+F + T + W ++ + + F+I FI+L ++ LN
Sbjct: 647 PTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLN 706
Query: 262 MFVGVMIMHTEDSIRKFERELMLEQQEMLMGEKQVILQRQQE--EISRL 308
+F+ + + D++ + EQ+E +++ LQ+ +E E+S L
Sbjct: 707 VFLAIAV----DNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPL 751
Score = 70.1 bits (170), Expect = 3e-12
Identities = 60/248 (24%), Positives = 112/248 (45%), Gaps = 36/248 (14%)
Query: 54 IIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPI-NYWKN 112
+I ++T+ F +Y+ R+F ++ F S+ + E +KV I NY+++
Sbjct: 1574 MIALNTIVLMMKFYGASVAYENALRVFNIV------FTSLFSLECVLKVMAFGILNYFRD 1627
Query: 113 GYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQ 172
+N+ D + ++ + + G F L ++ R++KL+ IR L+ Q
Sbjct: 1628 AWNIFDFVTVLGSITDILVTEF-GNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQ 1686
Query: 173 TVYTVASVLLLLFLLMYIFAILGFCLFGS------PDNGD--------HDNWGNLAAAFF 218
+ + V LL+ +L +I+AI+G +FG+ ++ D H+N+ A
Sbjct: 1687 SFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALM 1746
Query: 219 TLFSLATVDGWTDLQ------KQLDNREFALSRA--------FTIIFILLASFIFLNMFV 264
LF AT + W ++ K D L+R + + FI L SF+ LN+FV
Sbjct: 1747 LLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFV 1806
Query: 265 GVMIMHTE 272
V++ + E
Sbjct: 1807 AVIMDNFE 1814
Score = 63.2 bits (152), Expect = 4e-10
Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 70/323 (21%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSY--DIRYRLFRLLEFSEIFFVSI 93
D+ R + K++ F+ ++++T+ +N +AL D + + L+ +E +F+ I
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 94 CTSELSMKVYVDPI-----NYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E +K+ +Y +NG+N++D ++++ L +G +F L +
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILA-----TVGTEFD-LRTLRAV 197
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGF------------ 196
+ LR LKL+ ++ ++ ++ + + + + LLLF + IFAI+G
Sbjct: 198 RVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF 257
Query: 197 -----------------------CLFGS--------PDNGDHDNWGNLAAAFFTLFSLAT 225
C G+ P+NG + N+ A T+F T
Sbjct: 258 EEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNG-ITQFDNILFAVLTVFQCIT 316
Query: 226 VDGWTD-LQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELML 284
++GWTD L D + + I I++ SF LN+ +GV+ +F +E
Sbjct: 317 MEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVL-------SGEFAKE--- 366
Query: 285 EQQEMLMGEKQVILQRQQEEISR 307
+E + + + R+Q++I R
Sbjct: 367 --RERVENRRAFLKLRRQQQIER 387
Score = 55.1 bits (131), Expect = 1e-07
Identities = 53/292 (18%), Positives = 123/292 (42%), Gaps = 49/292 (16%)
Query: 46 VIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVY-- 103
++ R+F++ ++ + ++ +A +L + + F + T E+ +K+
Sbjct: 1239 ILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDL 1298
Query: 104 ---VDPINYWKNGYNLLDVIIIIVMFLPYALR-QLMGKQFTYLYIADGMQSLRILKLIGY 159
+ Y+++ +N+LD I++ + +A GK + ++ LR LK I
Sbjct: 1299 GLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKR 1358
Query: 160 SQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG------SPDNGDHD----- 208
++ + V ++ V ++L++ L M+IFA++ LF + ++ + +
Sbjct: 1359 LPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRG 1418
Query: 209 ----------------------NWGNLAAAFFTLFSLATVDGWTDLQKQLDNREFALS-- 244
++ N+ A TLF+++T +GW + K + F
Sbjct: 1419 KYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGP 1478
Query: 245 --------RAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQE 288
F +++ ++ F F+N+FV ++I+ ++ K E LE+ E
Sbjct: 1479 SPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNE 1530
>gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo
sapiens]
Length = 2261
Score = 87.4 bits (215), Expect = 2e-17
Identities = 69/289 (23%), Positives = 139/289 (48%), Gaps = 17/289 (5%)
Query: 32 FKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFV 91
F + + R +++R++ ++ F ++S V N +A+ Y+ L L ++E F+
Sbjct: 469 FHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAI-VHYNQPEWLSDFLYYAEFIFL 527
Query: 92 SICTSELSMKVY-VDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQS 150
+ SE+ +K+Y + Y+ + +N D +II + + + ++
Sbjct: 528 GLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRL 587
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPDNGDH--- 207
LRI K+ Y +R L+ ++ ++ ++ S+L LLFL + +FA+LG LFG N D
Sbjct: 588 LRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP 647
Query: 208 -DNWGNLAAAFFTLFSLATVDGWTDLQKQLDNREFAL--SRAFTIIFILL---ASFIFLN 261
N+ AA T+F + T + W ++ + + F+I FI+L ++ LN
Sbjct: 648 PTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLN 707
Query: 262 MFVGVMIMHTEDSIRKFERELMLEQQEMLMGEKQVILQRQQE--EISRL 308
+F+ + + D++ + EQ+E +++ LQ+ +E E+S L
Sbjct: 708 VFLAIAV----DNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPL 752
Score = 70.1 bits (170), Expect = 3e-12
Identities = 60/248 (24%), Positives = 112/248 (45%), Gaps = 36/248 (14%)
Query: 54 IIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPI-NYWKN 112
+I ++T+ F +Y+ R+F ++ F S+ + E +KV I NY+++
Sbjct: 1575 MIALNTIVLMMKFYGASVAYENALRVFNIV------FTSLFSLECVLKVMAFGILNYFRD 1628
Query: 113 GYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQ 172
+N+ D + ++ + + G F L ++ R++KL+ IR L+ Q
Sbjct: 1629 AWNIFDFVTVLGSITDILVTEF-GNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQ 1687
Query: 173 TVYTVASVLLLLFLLMYIFAILGFCLFGS------PDNGD--------HDNWGNLAAAFF 218
+ + V LL+ +L +I+AI+G +FG+ ++ D H+N+ A
Sbjct: 1688 SFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALM 1747
Query: 219 TLFSLATVDGWTDLQ------KQLDNREFALSRA--------FTIIFILLASFIFLNMFV 264
LF AT + W ++ K D L+R + + FI L SF+ LN+FV
Sbjct: 1748 LLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFV 1807
Query: 265 GVMIMHTE 272
V++ + E
Sbjct: 1808 AVIMDNFE 1815
Score = 63.2 bits (152), Expect = 4e-10
Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 70/323 (21%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSY--DIRYRLFRLLEFSEIFFVSI 93
D+ R + K++ F+ ++++T+ +N +AL D + + L+ +E +F+ I
Sbjct: 84 DNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGI 143
Query: 94 CTSELSMKVYVDPI-----NYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E +K+ +Y +NG+N++D ++++ L +G +F L +
Sbjct: 144 FCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILA-----TVGTEFD-LRTLRAV 197
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGF------------ 196
+ LR LKL+ ++ ++ ++ + + + + LLLF + IFAI+G
Sbjct: 198 RVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF 257
Query: 197 -----------------------CLFGS--------PDNGDHDNWGNLAAAFFTLFSLAT 225
C G+ P+NG + N+ A T+F T
Sbjct: 258 EEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNG-ITQFDNILFAVLTVFQCIT 316
Query: 226 VDGWTD-LQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELML 284
++GWTD L D + + I I++ SF LN+ +GV+ +F +E
Sbjct: 317 MEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVL-------SGEFAKE--- 366
Query: 285 EQQEMLMGEKQVILQRQQEEISR 307
+E + + + R+Q++I R
Sbjct: 367 --RERVENRRAFLKLRRQQQIER 387
Score = 55.1 bits (131), Expect = 1e-07
Identities = 53/292 (18%), Positives = 123/292 (42%), Gaps = 49/292 (16%)
Query: 46 VIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVY-- 103
++ R+F++ ++ + ++ +A +L + + F + T E+ +K+
Sbjct: 1240 ILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDL 1299
Query: 104 ---VDPINYWKNGYNLLDVIIIIVMFLPYALR-QLMGKQFTYLYIADGMQSLRILKLIGY 159
+ Y+++ +N+LD I++ + +A GK + ++ LR LK I
Sbjct: 1300 GLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKR 1359
Query: 160 SQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG------SPDNGDHD----- 208
++ + V ++ V ++L++ L M+IFA++ LF + ++ + +
Sbjct: 1360 LPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRG 1419
Query: 209 ----------------------NWGNLAAAFFTLFSLATVDGWTDLQKQLDNREFALS-- 244
++ N+ A TLF+++T +GW + K + F
Sbjct: 1420 KYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGP 1479
Query: 245 --------RAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQE 288
F +++ ++ F F+N+FV ++I+ ++ K E LE+ E
Sbjct: 1480 SPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNE 1531
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 87.4 bits (215), Expect = 2e-17
Identities = 72/282 (25%), Positives = 132/282 (46%), Gaps = 30/282 (10%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
R + + S + + + + N M++ Y+ L L++ F + E +
Sbjct: 1601 RRSIHSLCTSHYLDLFITFIICVNVITMSM-EHYNQPKSLDEALKYCNYVFTIVFVFEAA 1659
Query: 100 MKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYALRQL-----MGKQFTYLYIADGMQSLRI 153
+K+ ++K+ +N LD+ I+++ + L ++ + T + I ++ R+
Sbjct: 1660 LKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARV 1719
Query: 154 LKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG----SPDN----- 204
LKL+ + G+R L+ V Q + V ++ LL LL +I+A LG LFG S DN
Sbjct: 1720 LKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGL 1779
Query: 205 GDHDNWGNLAAAFFTLFSLATVDGWTDLQKQL---DNREF--------ALSRAFTIIFIL 253
H + N AF TLF ++T D W + K +RE ALS + + F+L
Sbjct: 1780 SRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVL 1839
Query: 254 LASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQ---EMLMG 292
+A F+ +N+ V V++ H E+S ++ + L+ + EM G
Sbjct: 1840 VAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQG 1881
Score = 82.4 bits (202), Expect = 7e-16
Identities = 62/239 (25%), Positives = 119/239 (49%), Gaps = 22/239 (9%)
Query: 43 VKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKV 102
++R++ S++F ++ + N M + ++ L LE S I F S+ E+ +K+
Sbjct: 786 LRRIVDSKYFSRGIMMAILVNTLSMGV-EYHEQPEELTNALEISNIVFTSMFALEMLLKL 844
Query: 103 YV-DPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQ 161
P+ Y +N YN+ D II+++ ++ +++G+ L + + LR+LKL+ +
Sbjct: 845 LACGPLGYIRNPYNIFDGIIVVI-----SVWEIVGQADGGLSVLRTFRLLRVLKLVRFLP 899
Query: 162 GIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG-----SPDNG----DHDNWGN 212
+R + + +T+ VA+ LL L ++IF+ILG LFG D G D N+ +
Sbjct: 900 ALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDS 959
Query: 213 LAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI 268
L A T+F + T + W + L N + S + F+ L +F + N+ V +++
Sbjct: 960 LLWAIVTVFQILTQEDWNVV---LYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015
Score = 63.2 bits (152), Expect = 4e-10
Identities = 67/276 (24%), Positives = 122/276 (44%), Gaps = 51/276 (18%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDI----RYRLFRLLEFSEIFFVSICT 95
R ++VI + F +++ + N +AL DI R+F L S F +I
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERP-DIDPGSTERVF--LSVSNYIFTAIFV 1340
Query: 96 SELSMKVYVDPI-----NYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADG 147
+E+ +KV + Y ++ +NLLD ++++V + + K L +
Sbjct: 1341 AEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRL 1400
Query: 148 MQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGS------ 201
+++LR L++I + G++ ++ + ++ + +++L+ IF ILG LF
Sbjct: 1401 LRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCE 1460
Query: 202 -PDNGD----------HDNW-------GNLAAAFFTLFSLATVDGWTDL----------- 232
PD + H W NL A +LF L++ DGW ++
Sbjct: 1461 GPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVD 1520
Query: 233 QKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMI 268
Q+ + N + F I F+L+ SF LNMFVGV++
Sbjct: 1521 QQPVQNHNPWMLLYF-ISFLLIVSFFVLNMFVGVVV 1555
Score = 37.7 bits (86), Expect = 0.018
Identities = 36/167 (21%), Positives = 77/167 (46%), Gaps = 11/167 (6%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWT---SYDIRYRLFRLLEFSEIFFVSICTS 96
R++ R++ + +F+ + + + N + ++ + +LE + F +
Sbjct: 90 RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAV 149
Query: 97 ELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLR 152
E+ +K+ + Y + +N LD I++ + Y+L G + I ++ LR
Sbjct: 150 EMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLD---GHNVSLSAIRT-VRVLR 205
Query: 153 ILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 206 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform a [Homo sapiens]
Length = 2353
Score = 87.4 bits (215), Expect = 2e-17
Identities = 72/282 (25%), Positives = 132/282 (46%), Gaps = 30/282 (10%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
R + + S + + + + N M++ Y+ L L++ F + E +
Sbjct: 1607 RRSIHSLCTSHYLDLFITFIICVNVITMSM-EHYNQPKSLDEALKYCNYVFTIVFVFEAA 1665
Query: 100 MKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYALRQL-----MGKQFTYLYIADGMQSLRI 153
+K+ ++K+ +N LD+ I+++ + L ++ + T + I ++ R+
Sbjct: 1666 LKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARV 1725
Query: 154 LKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG----SPDN----- 204
LKL+ + G+R L+ V Q + V ++ LL LL +I+A LG LFG S DN
Sbjct: 1726 LKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGL 1785
Query: 205 GDHDNWGNLAAAFFTLFSLATVDGWTDLQKQL---DNREF--------ALSRAFTIIFIL 253
H + N AF TLF ++T D W + K +RE ALS + + F+L
Sbjct: 1786 SRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVL 1845
Query: 254 LASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQ---EMLMG 292
+A F+ +N+ V V++ H E+S ++ + L+ + EM G
Sbjct: 1846 VAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQG 1887
Score = 82.4 bits (202), Expect = 7e-16
Identities = 62/239 (25%), Positives = 119/239 (49%), Gaps = 22/239 (9%)
Query: 43 VKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKV 102
++R++ S++F ++ + N M + ++ L LE S I F S+ E+ +K+
Sbjct: 786 LRRIVDSKYFSRGIMMAILVNTLSMGV-EYHEQPEELTNALEISNIVFTSMFALEMLLKL 844
Query: 103 YV-DPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQ 161
P+ Y +N YN+ D II+++ ++ +++G+ L + + LR+LKL+ +
Sbjct: 845 LACGPLGYIRNPYNIFDGIIVVI-----SVWEIVGQADGGLSVLRTFRLLRVLKLVRFLP 899
Query: 162 GIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG-----SPDNG----DHDNWGN 212
+R + + +T+ VA+ LL L ++IF+ILG LFG D G D N+ +
Sbjct: 900 ALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDS 959
Query: 213 LAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI 268
L A T+F + T + W + L N + S + F+ L +F + N+ V +++
Sbjct: 960 LLWAIVTVFQILTQEDWNVV---LYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015
Score = 63.2 bits (152), Expect = 4e-10
Identities = 67/276 (24%), Positives = 122/276 (44%), Gaps = 51/276 (18%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDI----RYRLFRLLEFSEIFFVSICT 95
R ++VI + F +++ + N +AL DI R+F L S F +I
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERP-DIDPGSTERVF--LSVSNYIFTAIFV 1340
Query: 96 SELSMKVYVDPI-----NYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADG 147
+E+ +KV + Y ++ +NLLD ++++V + + K L +
Sbjct: 1341 AEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRL 1400
Query: 148 MQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGS------ 201
+++LR L++I + G++ ++ + ++ + +++L+ IF ILG LF
Sbjct: 1401 LRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCE 1460
Query: 202 -PDNGD----------HDNW-------GNLAAAFFTLFSLATVDGWTDL----------- 232
PD + H W NL A +LF L++ DGW ++
Sbjct: 1461 GPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVD 1520
Query: 233 QKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMI 268
Q+ + N + F I F+L+ SF LNMFVGV++
Sbjct: 1521 QQPVQNHNPWMLLYF-ISFLLIVSFFVLNMFVGVVV 1555
Score = 37.7 bits (86), Expect = 0.018
Identities = 36/167 (21%), Positives = 77/167 (46%), Gaps = 11/167 (6%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWT---SYDIRYRLFRLLEFSEIFFVSICTS 96
R++ R++ + +F+ + + + N + ++ + +LE + F +
Sbjct: 90 RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAV 149
Query: 97 ELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLR 152
E+ +K+ + Y + +N LD I++ + Y+L G + I ++ LR
Sbjct: 150 EMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLD---GHNVSLSAIRT-VRVLR 205
Query: 153 ILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 206 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
isoform 3 [Homo sapiens]
Length = 2343
Score = 86.3 bits (212), Expect = 5e-17
Identities = 74/294 (25%), Positives = 135/294 (45%), Gaps = 41/294 (13%)
Query: 6 HQRHSRVISSSPVDTTSVGF----CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVT 61
H R R + ++ + F C TF+K ++ S++F ++ +
Sbjct: 709 HSRRQRSLGPDAEPSSVLAFWRLICDTFRK--------------IVDSKYFGRGIMIAIL 754
Query: 62 SNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-DPINYWKNGYNLLDVI 120
N M + ++ L LE S I F S+ E+ +K+ V P Y KN YN+ D +
Sbjct: 755 VNTLSMGI-EYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGV 813
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
I+++ ++ +++G+Q L + + +R+LKL+ + ++ + + +T+ VA+
Sbjct: 814 IVVI-----SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
Query: 181 LLLLFLLMYIFAILGF----CLFGSPDNG----DHDNWGNLAAAFFTLFSLATVDGWTDL 232
+LL L ++IF+ILG C F S +G D N+ +L A T+F + T + W
Sbjct: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDW--- 925
Query: 233 QKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI--MHTEDSIRKFERE 281
K L N + S + FI L +F + N+ V +++ E K E E
Sbjct: 926 NKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979
Score = 83.6 bits (205), Expect = 3e-16
Identities = 67/271 (24%), Positives = 121/271 (44%), Gaps = 24/271 (8%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
R V + S + + + + N MA+ Y L L+ F I E
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAM-EHYQQPQILDEALKICNYIFTVIFVLESV 1625
Query: 100 MKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYALRQL-----MGKQFTYLYIADGMQSLRI 153
K+ ++++ +N LD+ I+++ + L ++ + T + I ++ R+
Sbjct: 1626 FKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARV 1685
Query: 154 LKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPD---------N 204
LKL+ + G+R L+ V Q + V ++ LL LL +IFA LG LFG +
Sbjct: 1686 LKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGL 1745
Query: 205 GDHDNWGNLAAAFFTLFSLATVDGWT--------DLQKQLDNREFALSRAFTIIFILLAS 256
G H + N AF TLF ++T D W D ++ +S + + F+L A
Sbjct: 1746 GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805
Query: 257 FIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
F+ +N+ + V++ H E+S ++ + E LE +
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1836
Score = 66.6 bits (161), Expect = 4e-11
Identities = 65/311 (20%), Positives = 136/311 (43%), Gaps = 56/311 (18%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRL-LEFSEIFFVSICTSEL 98
R R+I + F +++ + N +A+ + R+ L S F ++ +E+
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 99 SMKVYV-----DPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADGMQS 150
++KV Y ++ +N+LD +++++ + + + K L + +++
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF----------- 199
LR L++I +QG++ ++ + ++ + +++++ IF ILG LF
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422
Query: 200 -----GSPDNGDHD--------NWGNLAAAFFTLFSLATVDGWTDL------------QK 234
D + N+ NL A +LF LA+ DGW D+ Q
Sbjct: 1423 TRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQP 1482
Query: 235 QLDNREFALSRAFTIIFILLASFIFLNMFVGVMI---------MHTEDSIRKFERELMLE 285
+++ + L + I F+L+ +F LNMFVGV++ E++ R+ E+ L
Sbjct: 1483 IMNHNPWML--LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540
Query: 286 QQEMLMGEKQV 296
+++ EKQ+
Sbjct: 1541 EKKRRSKEKQM 1551
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 11/171 (6%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYD---IRYRLFRLLEFSEIFFVS 92
D R++ R + + +F+ I + + N + ++ + + R+L+ + F +
Sbjct: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 93 ICTSELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E+ +K+ I Y + +N LD I+I L Y+L L F+ + +
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRT---V 182
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ LR L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 183 RVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
isoform 13 [Homo sapiens]
Length = 2243
Score = 86.3 bits (212), Expect = 5e-17
Identities = 74/294 (25%), Positives = 135/294 (45%), Gaps = 41/294 (13%)
Query: 6 HQRHSRVISSSPVDTTSVGF----CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVT 61
H R R + ++ + F C TF+K ++ S++F ++ +
Sbjct: 709 HSRRQRSLGPDAEPSSVLAFWRLICDTFRK--------------IVDSKYFGRGIMIAIL 754
Query: 62 SNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-DPINYWKNGYNLLDVI 120
N M + ++ L LE S I F S+ E+ +K+ V P Y KN YN+ D +
Sbjct: 755 VNTLSMGI-EYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGV 813
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
I+++ ++ +++G+Q L + + +R+LKL+ + ++ + + +T+ VA+
Sbjct: 814 IVVI-----SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
Query: 181 LLLLFLLMYIFAILGF----CLFGSPDNG----DHDNWGNLAAAFFTLFSLATVDGWTDL 232
+LL L ++IF+ILG C F S +G D N+ +L A T+F + T + W
Sbjct: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDW--- 925
Query: 233 QKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI--MHTEDSIRKFERE 281
K L N + S + FI L +F + N+ V +++ E K E E
Sbjct: 926 NKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979
Score = 83.6 bits (205), Expect = 3e-16
Identities = 67/271 (24%), Positives = 121/271 (44%), Gaps = 24/271 (8%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
R V + S + + + + N MA+ Y L L+ F I E
Sbjct: 1560 RLLVHHLCTSHYLDLFITGVIGLNVVTMAM-EHYQQPQILDEALKICNYIFTVIFVLESV 1618
Query: 100 MKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYALRQL-----MGKQFTYLYIADGMQSLRI 153
K+ ++++ +N LD+ I+++ + L ++ + T + I ++ R+
Sbjct: 1619 FKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARV 1678
Query: 154 LKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPD---------N 204
LKL+ + G+R L+ V Q + V ++ LL LL +IFA LG LFG +
Sbjct: 1679 LKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGL 1738
Query: 205 GDHDNWGNLAAAFFTLFSLATVDGWT--------DLQKQLDNREFALSRAFTIIFILLAS 256
G H + N AF TLF ++T D W D ++ +S + + F+L A
Sbjct: 1739 GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1798
Query: 257 FIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
F+ +N+ + V++ H E+S ++ + E LE +
Sbjct: 1799 FVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1829
Score = 67.8 bits (164), Expect = 2e-11
Identities = 67/339 (19%), Positives = 145/339 (42%), Gaps = 61/339 (17%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRL-LEFSEIFFVSICTSEL 98
R R+I + F +++ + N +A+ + R+ L S F ++ +E+
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 99 SMKVYV-----DPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADGMQS 150
++KV Y ++ +N+LD +++++ + + + K L + +++
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF----------- 199
LR L++I +QG++ ++ + ++ + +++++ IF ILG LF
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422
Query: 200 -----GSPDNGDHD--------NWGNLAAAFFTLFSLATVDGWTDL------------QK 234
D + N+ NL A +LF LA+ DGW D+ Q
Sbjct: 1423 TRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQP 1482
Query: 235 QLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQEMLMGEK 294
+++ + L + I F+L+ +F LNMFVGV++ ++ K + E+
Sbjct: 1483 IMNHNPWML--LYFISFLLIVAFFVLNMFVGVVV----ENFHKCRQH----------QEE 1526
Query: 295 QVILQRQQEEISRLMHIQKNADCTSFSELVENFKKTLSH 333
+ +R+++ + RL ++ A C + F+ + H
Sbjct: 1527 EEARRREEKRLRRLEKKRRKAQCKPYYSDYSRFRLLVHH 1565
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 11/171 (6%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYD---IRYRLFRLLEFSEIFFVS 92
D R++ R + + +F+ I + + N + ++ + + R+L+ + F +
Sbjct: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 93 ICTSELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E+ +K+ I Y + +N LD I+I L Y+L L F+ + +
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRT---V 182
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ LR L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 183 RVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
isoform 12 [Homo sapiens]
Length = 2250
Score = 86.3 bits (212), Expect = 5e-17
Identities = 74/294 (25%), Positives = 135/294 (45%), Gaps = 41/294 (13%)
Query: 6 HQRHSRVISSSPVDTTSVGF----CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVT 61
H R R + ++ + F C TF+K ++ S++F ++ +
Sbjct: 709 HSRRQRSLGPDAEPSSVLAFWRLICDTFRK--------------IVDSKYFGRGIMIAIL 754
Query: 62 SNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-DPINYWKNGYNLLDVI 120
N M + ++ L LE S I F S+ E+ +K+ V P Y KN YN+ D +
Sbjct: 755 VNTLSMGI-EYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGV 813
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
I+++ ++ +++G+Q L + + +R+LKL+ + ++ + + +T+ VA+
Sbjct: 814 IVVI-----SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
Query: 181 LLLLFLLMYIFAILGF----CLFGSPDNG----DHDNWGNLAAAFFTLFSLATVDGWTDL 232
+LL L ++IF+ILG C F S +G D N+ +L A T+F + T + W
Sbjct: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDW--- 925
Query: 233 QKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI--MHTEDSIRKFERE 281
K L N + S + FI L +F + N+ V +++ E K E E
Sbjct: 926 NKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979
Score = 83.6 bits (205), Expect = 3e-16
Identities = 67/271 (24%), Positives = 121/271 (44%), Gaps = 24/271 (8%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
R V + S + + + + N MA+ Y L L+ F I E
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAM-EHYQQPQILDEALKICNYIFTVIFVLESV 1625
Query: 100 MKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYALRQL-----MGKQFTYLYIADGMQSLRI 153
K+ ++++ +N LD+ I+++ + L ++ + T + I ++ R+
Sbjct: 1626 FKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARV 1685
Query: 154 LKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPD---------N 204
LKL+ + G+R L+ V Q + V ++ LL LL +IFA LG LFG +
Sbjct: 1686 LKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGL 1745
Query: 205 GDHDNWGNLAAAFFTLFSLATVDGWT--------DLQKQLDNREFALSRAFTIIFILLAS 256
G H + N AF TLF ++T D W D ++ +S + + F+L A
Sbjct: 1746 GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805
Query: 257 FIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
F+ +N+ + V++ H E+S ++ + E LE +
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1836
Score = 66.6 bits (161), Expect = 4e-11
Identities = 65/311 (20%), Positives = 136/311 (43%), Gaps = 56/311 (18%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRL-LEFSEIFFVSICTSEL 98
R R+I + F +++ + N +A+ + R+ L S F ++ +E+
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 99 SMKVYV-----DPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADGMQS 150
++KV Y ++ +N+LD +++++ + + + K L + +++
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF----------- 199
LR L++I +QG++ ++ + ++ + +++++ IF ILG LF
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422
Query: 200 -----GSPDNGDHD--------NWGNLAAAFFTLFSLATVDGWTDL------------QK 234
D + N+ NL A +LF LA+ DGW D+ Q
Sbjct: 1423 TRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQP 1482
Query: 235 QLDNREFALSRAFTIIFILLASFIFLNMFVGVMI---------MHTEDSIRKFERELMLE 285
+++ + L + I F+L+ +F LNMFVGV++ E++ R+ E+ L
Sbjct: 1483 IMNHNPWML--LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540
Query: 286 QQEMLMGEKQV 296
+++ EKQ+
Sbjct: 1541 EKKRRSKEKQM 1551
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 11/171 (6%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYD---IRYRLFRLLEFSEIFFVS 92
D R++ R + + +F+ I + + N + ++ + + R+L+ + F +
Sbjct: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 93 ICTSELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E+ +K+ I Y + +N LD I+I L Y+L L F+ + +
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRT---V 182
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ LR L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 183 RVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
isoform 6 [Homo sapiens]
Length = 2306
Score = 86.3 bits (212), Expect = 5e-17
Identities = 74/294 (25%), Positives = 135/294 (45%), Gaps = 41/294 (13%)
Query: 6 HQRHSRVISSSPVDTTSVGF----CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVT 61
H R R + ++ + F C TF+K ++ S++F ++ +
Sbjct: 709 HSRRQRSLGPDAEPSSVLAFWRLICDTFRK--------------IVDSKYFGRGIMIAIL 754
Query: 62 SNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-DPINYWKNGYNLLDVI 120
N M + ++ L LE S I F S+ E+ +K+ V P Y KN YN+ D +
Sbjct: 755 VNTLSMGI-EYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGV 813
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
I+++ ++ +++G+Q L + + +R+LKL+ + ++ + + +T+ VA+
Sbjct: 814 IVVI-----SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
Query: 181 LLLLFLLMYIFAILGF----CLFGSPDNG----DHDNWGNLAAAFFTLFSLATVDGWTDL 232
+LL L ++IF+ILG C F S +G D N+ +L A T+F + T + W
Sbjct: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDW--- 925
Query: 233 QKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI--MHTEDSIRKFERE 281
K L N + S + FI L +F + N+ V +++ E K E E
Sbjct: 926 NKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979
Score = 84.7 bits (208), Expect = 1e-16
Identities = 72/299 (24%), Positives = 129/299 (43%), Gaps = 27/299 (9%)
Query: 12 VISSSPVDTTSVGFCPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWT 71
+ S S S C K + + R V + S + + + + N MA+
Sbjct: 1553 IASGSSASAASEAQC---KPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM-E 1608
Query: 72 SYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYA 130
Y L L+ F I E K+ ++++ +N LD+ I+++ +
Sbjct: 1609 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1668
Query: 131 LRQL-----MGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLF 185
L ++ + T + I ++ R+LKL+ + G+R L+ V Q + V ++ LL
Sbjct: 1669 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1728
Query: 186 LLMYIFAILGFCLFGSPD---------NGDHDNWGNLAAAFFTLFSLATVDGWT------ 230
LL +IFA LG LFG + G H + N AF TLF ++T D W
Sbjct: 1729 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1788
Query: 231 --DLQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
D ++ +S + + F+L A F+ +N+ + V++ H E+S ++ + E LE +
Sbjct: 1789 LRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1847
Score = 64.3 bits (155), Expect = 2e-10
Identities = 61/294 (20%), Positives = 128/294 (43%), Gaps = 47/294 (15%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRL-LEFSEIFFVSICTSEL 98
R R+I + F +++ + N +A+ + R+ L S F ++ +E+
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 99 SMKVYV-----DPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADGMQS 150
++KV Y ++ +N+LD +++++ + + + K L + +++
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF----------- 199
LR L++I +QG++ ++ + ++ + +++++ IF ILG LF
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422
Query: 200 -----GSPDNGDHD--------NWGNLAAAFFTLFSLATVDGWTDL------------QK 234
D + N+ NL A +LF LA+ DGW D+ Q
Sbjct: 1423 TRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQP 1482
Query: 235 QLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQE 288
+++ + L + I F+L+ +F LNMFVGV++ + + E E ++E
Sbjct: 1483 IMNHNPWML--LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 11/171 (6%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYD---IRYRLFRLLEFSEIFFVS 92
D R++ R + + +F+ I + + N + ++ + + R+L+ + F +
Sbjct: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 93 ICTSELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E+ +K+ I Y + +N LD I+I L Y+L L F+ + +
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRT---V 182
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ LR L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 183 RVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
isoform 11 [Homo sapiens]
Length = 2261
Score = 86.3 bits (212), Expect = 5e-17
Identities = 74/294 (25%), Positives = 135/294 (45%), Gaps = 41/294 (13%)
Query: 6 HQRHSRVISSSPVDTTSVGF----CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVT 61
H R R + ++ + F C TF+K ++ S++F ++ +
Sbjct: 709 HSRRQRSLGPDAEPSSVLAFWRLICDTFRK--------------IVDSKYFGRGIMIAIL 754
Query: 62 SNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-DPINYWKNGYNLLDVI 120
N M + ++ L LE S I F S+ E+ +K+ V P Y KN YN+ D +
Sbjct: 755 VNTLSMGI-EYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGV 813
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
I+++ ++ +++G+Q L + + +R+LKL+ + ++ + + +T+ VA+
Sbjct: 814 IVVI-----SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
Query: 181 LLLLFLLMYIFAILGF----CLFGSPDNG----DHDNWGNLAAAFFTLFSLATVDGWTDL 232
+LL L ++IF+ILG C F S +G D N+ +L A T+F + T + W
Sbjct: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDW--- 925
Query: 233 QKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI--MHTEDSIRKFERE 281
K L N + S + FI L +F + N+ V +++ E K E E
Sbjct: 926 NKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979
Score = 84.7 bits (208), Expect = 1e-16
Identities = 72/299 (24%), Positives = 129/299 (43%), Gaps = 27/299 (9%)
Query: 12 VISSSPVDTTSVGFCPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWT 71
+ S S S C K + + R V + S + + + + N MA+
Sbjct: 1553 IASGSSASAASEAQC---KPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM-E 1608
Query: 72 SYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYA 130
Y L L+ F I E K+ ++++ +N LD+ I+++ +
Sbjct: 1609 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1668
Query: 131 LRQL-----MGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLF 185
L ++ + T + I ++ R+LKL+ + G+R L+ V Q + V ++ LL
Sbjct: 1669 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1728
Query: 186 LLMYIFAILGFCLFGSPD---------NGDHDNWGNLAAAFFTLFSLATVDGWT------ 230
LL +IFA LG LFG + G H + N AF TLF ++T D W
Sbjct: 1729 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1788
Query: 231 --DLQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
D ++ +S + + F+L A F+ +N+ + V++ H E+S ++ + E LE +
Sbjct: 1789 LRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1847
Score = 64.3 bits (155), Expect = 2e-10
Identities = 61/294 (20%), Positives = 128/294 (43%), Gaps = 47/294 (15%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRL-LEFSEIFFVSICTSEL 98
R R+I + F +++ + N +A+ + R+ L S F ++ +E+
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 99 SMKVYV-----DPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADGMQS 150
++KV Y ++ +N+LD +++++ + + + K L + +++
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF----------- 199
LR L++I +QG++ ++ + ++ + +++++ IF ILG LF
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422
Query: 200 -----GSPDNGDHD--------NWGNLAAAFFTLFSLATVDGWTDL------------QK 234
D + N+ NL A +LF LA+ DGW D+ Q
Sbjct: 1423 TRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQP 1482
Query: 235 QLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQE 288
+++ + L + I F+L+ +F LNMFVGV++ + + E E ++E
Sbjct: 1483 IMNHNPWML--LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 11/171 (6%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYD---IRYRLFRLLEFSEIFFVS 92
D R++ R + + +F+ I + + N + ++ + + R+L+ + F +
Sbjct: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 93 ICTSELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E+ +K+ I Y + +N LD I+I L Y+L L F+ + +
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRT---V 182
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ LR L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 183 RVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
isoform 7 [Homo sapiens]
Length = 2298
Score = 86.3 bits (212), Expect = 5e-17
Identities = 74/294 (25%), Positives = 135/294 (45%), Gaps = 41/294 (13%)
Query: 6 HQRHSRVISSSPVDTTSVGF----CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVT 61
H R R + ++ + F C TF+K ++ S++F ++ +
Sbjct: 709 HSRRQRSLGPDAEPSSVLAFWRLICDTFRK--------------IVDSKYFGRGIMIAIL 754
Query: 62 SNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-DPINYWKNGYNLLDVI 120
N M + ++ L LE S I F S+ E+ +K+ V P Y KN YN+ D +
Sbjct: 755 VNTLSMGI-EYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGV 813
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
I+++ ++ +++G+Q L + + +R+LKL+ + ++ + + +T+ VA+
Sbjct: 814 IVVI-----SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
Query: 181 LLLLFLLMYIFAILGF----CLFGSPDNG----DHDNWGNLAAAFFTLFSLATVDGWTDL 232
+LL L ++IF+ILG C F S +G D N+ +L A T+F + T + W
Sbjct: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDW--- 925
Query: 233 QKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI--MHTEDSIRKFERE 281
K L N + S + FI L +F + N+ V +++ E K E E
Sbjct: 926 NKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979
Score = 83.6 bits (205), Expect = 3e-16
Identities = 67/271 (24%), Positives = 121/271 (44%), Gaps = 24/271 (8%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
R V + S + + + + N MA+ Y L L+ F I E
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAM-EHYQQPQILDEALKICNYIFTVIFVLESV 1625
Query: 100 MKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYALRQL-----MGKQFTYLYIADGMQSLRI 153
K+ ++++ +N LD+ I+++ + L ++ + T + I ++ R+
Sbjct: 1626 FKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARV 1685
Query: 154 LKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPD---------N 204
LKL+ + G+R L+ V Q + V ++ LL LL +IFA LG LFG +
Sbjct: 1686 LKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGL 1745
Query: 205 GDHDNWGNLAAAFFTLFSLATVDGWT--------DLQKQLDNREFALSRAFTIIFILLAS 256
G H + N AF TLF ++T D W D ++ +S + + F+L A
Sbjct: 1746 GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805
Query: 257 FIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
F+ +N+ + V++ H E+S ++ + E LE +
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1836
Score = 66.6 bits (161), Expect = 4e-11
Identities = 65/311 (20%), Positives = 136/311 (43%), Gaps = 56/311 (18%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRL-LEFSEIFFVSICTSEL 98
R R+I + F +++ + N +A+ + R+ L S F ++ +E+
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 99 SMKVYV-----DPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADGMQS 150
++KV Y ++ +N+LD +++++ + + + K L + +++
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF----------- 199
LR L++I +QG++ ++ + ++ + +++++ IF ILG LF
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422
Query: 200 -----GSPDNGDHD--------NWGNLAAAFFTLFSLATVDGWTDL------------QK 234
D + N+ NL A +LF LA+ DGW D+ Q
Sbjct: 1423 TRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQP 1482
Query: 235 QLDNREFALSRAFTIIFILLASFIFLNMFVGVMI---------MHTEDSIRKFERELMLE 285
+++ + L + I F+L+ +F LNMFVGV++ E++ R+ E+ L
Sbjct: 1483 IMNHNPWML--LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540
Query: 286 QQEMLMGEKQV 296
+++ EKQ+
Sbjct: 1541 EKKRRSKEKQM 1551
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 11/171 (6%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYD---IRYRLFRLLEFSEIFFVS 92
D R++ R + + +F+ I + + N + ++ + + R+L+ + F +
Sbjct: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 93 ICTSELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E+ +K+ I Y + +N LD I+I L Y+L L F+ + +
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRT---V 182
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ LR L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 183 RVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
isoform 2 [Homo sapiens]
Length = 2354
Score = 86.3 bits (212), Expect = 5e-17
Identities = 74/294 (25%), Positives = 135/294 (45%), Gaps = 41/294 (13%)
Query: 6 HQRHSRVISSSPVDTTSVGF----CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVT 61
H R R + ++ + F C TF+K ++ S++F ++ +
Sbjct: 709 HSRRQRSLGPDAEPSSVLAFWRLICDTFRK--------------IVDSKYFGRGIMIAIL 754
Query: 62 SNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-DPINYWKNGYNLLDVI 120
N M + ++ L LE S I F S+ E+ +K+ V P Y KN YN+ D +
Sbjct: 755 VNTLSMGI-EYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGV 813
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
I+++ ++ +++G+Q L + + +R+LKL+ + ++ + + +T+ VA+
Sbjct: 814 IVVI-----SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
Query: 181 LLLLFLLMYIFAILGF----CLFGSPDNG----DHDNWGNLAAAFFTLFSLATVDGWTDL 232
+LL L ++IF+ILG C F S +G D N+ +L A T+F + T + W
Sbjct: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDW--- 925
Query: 233 QKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI--MHTEDSIRKFERE 281
K L N + S + FI L +F + N+ V +++ E K E E
Sbjct: 926 NKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979
Score = 84.7 bits (208), Expect = 1e-16
Identities = 72/299 (24%), Positives = 129/299 (43%), Gaps = 27/299 (9%)
Query: 12 VISSSPVDTTSVGFCPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWT 71
+ S S S C K + + R V + S + + + + N MA+
Sbjct: 1553 IASGSSASAASEAQC---KPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM-E 1608
Query: 72 SYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYA 130
Y L L+ F I E K+ ++++ +N LD+ I+++ +
Sbjct: 1609 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1668
Query: 131 LRQL-----MGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLF 185
L ++ + T + I ++ R+LKL+ + G+R L+ V Q + V ++ LL
Sbjct: 1669 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1728
Query: 186 LLMYIFAILGFCLFGSPD---------NGDHDNWGNLAAAFFTLFSLATVDGWT------ 230
LL +IFA LG LFG + G H + N AF TLF ++T D W
Sbjct: 1729 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1788
Query: 231 --DLQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
D ++ +S + + F+L A F+ +N+ + V++ H E+S ++ + E LE +
Sbjct: 1789 LRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1847
Score = 64.3 bits (155), Expect = 2e-10
Identities = 61/294 (20%), Positives = 128/294 (43%), Gaps = 47/294 (15%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRL-LEFSEIFFVSICTSEL 98
R R+I + F +++ + N +A+ + R+ L S F ++ +E+
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 99 SMKVYV-----DPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADGMQS 150
++KV Y ++ +N+LD +++++ + + + K L + +++
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF----------- 199
LR L++I +QG++ ++ + ++ + +++++ IF ILG LF
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422
Query: 200 -----GSPDNGDHD--------NWGNLAAAFFTLFSLATVDGWTDL------------QK 234
D + N+ NL A +LF LA+ DGW D+ Q
Sbjct: 1423 TRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQP 1482
Query: 235 QLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQE 288
+++ + L + I F+L+ +F LNMFVGV++ + + E E ++E
Sbjct: 1483 IMNHNPWML--LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 11/171 (6%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYD---IRYRLFRLLEFSEIFFVS 92
D R++ R + + +F+ I + + N + ++ + + R+L+ + F +
Sbjct: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 93 ICTSELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E+ +K+ I Y + +N LD I+I L Y+L L F+ + +
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRT---V 182
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ LR L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 183 RVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
isoform 14 [Homo sapiens]
Length = 2171
Score = 86.3 bits (212), Expect = 5e-17
Identities = 74/294 (25%), Positives = 135/294 (45%), Gaps = 41/294 (13%)
Query: 6 HQRHSRVISSSPVDTTSVGF----CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVT 61
H R R + ++ + F C TF+K ++ S++F ++ +
Sbjct: 709 HSRRQRSLGPDAEPSSVLAFWRLICDTFRK--------------IVDSKYFGRGIMIAIL 754
Query: 62 SNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-DPINYWKNGYNLLDVI 120
N M + ++ L LE S I F S+ E+ +K+ V P Y KN YN+ D +
Sbjct: 755 VNTLSMGI-EYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGV 813
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
I+++ ++ +++G+Q L + + +R+LKL+ + ++ + + +T+ VA+
Sbjct: 814 IVVI-----SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
Query: 181 LLLLFLLMYIFAILGF----CLFGSPDNG----DHDNWGNLAAAFFTLFSLATVDGWTDL 232
+LL L ++IF+ILG C F S +G D N+ +L A T+F + T + W
Sbjct: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDW--- 925
Query: 233 QKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI--MHTEDSIRKFERE 281
K L N + S + FI L +F + N+ V +++ E K E E
Sbjct: 926 NKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979
Score = 83.6 bits (205), Expect = 3e-16
Identities = 67/271 (24%), Positives = 121/271 (44%), Gaps = 24/271 (8%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
R V + S + + + + N MA+ Y L L+ F I E
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAM-EHYQQPQILDEALKICNYIFTVIFVLESV 1625
Query: 100 MKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYALRQL-----MGKQFTYLYIADGMQSLRI 153
K+ ++++ +N LD+ I+++ + L ++ + T + I ++ R+
Sbjct: 1626 FKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARV 1685
Query: 154 LKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPD---------N 204
LKL+ + G+R L+ V Q + V ++ LL LL +IFA LG LFG +
Sbjct: 1686 LKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGL 1745
Query: 205 GDHDNWGNLAAAFFTLFSLATVDGWT--------DLQKQLDNREFALSRAFTIIFILLAS 256
G H + N AF TLF ++T D W D ++ +S + + F+L A
Sbjct: 1746 GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805
Query: 257 FIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
F+ +N+ + V++ H E+S ++ + E LE +
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1836
Score = 66.6 bits (161), Expect = 4e-11
Identities = 65/311 (20%), Positives = 136/311 (43%), Gaps = 56/311 (18%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRL-LEFSEIFFVSICTSEL 98
R R+I + F +++ + N +A+ + R+ L S F ++ +E+
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302
Query: 99 SMKVYV-----DPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADGMQS 150
++KV Y ++ +N+LD +++++ + + + K L + +++
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF----------- 199
LR L++I +QG++ ++ + ++ + +++++ IF ILG LF
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422
Query: 200 -----GSPDNGDHD--------NWGNLAAAFFTLFSLATVDGWTDL------------QK 234
D + N+ NL A +LF LA+ DGW D+ Q
Sbjct: 1423 TRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQP 1482
Query: 235 QLDNREFALSRAFTIIFILLASFIFLNMFVGVMI---------MHTEDSIRKFERELMLE 285
+++ + L + I F+L+ +F LNMFVGV++ E++ R+ E+ L
Sbjct: 1483 IMNHNPWML--LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540
Query: 286 QQEMLMGEKQV 296
+++ EKQ+
Sbjct: 1541 EKKRRSKEKQM 1551
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 11/171 (6%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYD---IRYRLFRLLEFSEIFFVS 92
D R++ R + + +F+ I + + N + ++ + + R+L+ + F +
Sbjct: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 93 ICTSELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E+ +K+ I Y + +N LD I+I L Y+L L F+ + +
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRT---V 182
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ LR L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 183 RVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform b [Homo sapiens]
Length = 2188
Score = 85.9 bits (211), Expect = 6e-17
Identities = 67/275 (24%), Positives = 130/275 (47%), Gaps = 29/275 (10%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
R + + S + I + + N M+L Y+ L L++ F ++ E
Sbjct: 1442 RLLIHSMCTSHYLDIFITFIICLNVVTMSL-EHYNQPTSLETALKYCNYMFTTVFVLEAV 1500
Query: 100 MKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYALRQL-----MGKQFTYLYIADGMQSLRI 153
+K+ + ++K+ +N LD+ I+++ + L ++ + T + I ++ R+
Sbjct: 1501 LKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARV 1560
Query: 154 LKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG-------SPDNG- 205
LKL+ + G+R L+ V Q + V ++ LL LL +I+A LG LFG +P G
Sbjct: 1561 LKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGM 1620
Query: 206 -DHDNWGNLAAAFFTLFSLATVDGWTDLQKQ------------LDNREFALSRAFTIIFI 252
H + N AF TLF ++T D W + K L + +F +S + + F+
Sbjct: 1621 SRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQF-VSPLYFVSFV 1679
Query: 253 LLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
L A F+ +N+ V V++ H +DS ++ + + ++ +
Sbjct: 1680 LTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAE 1714
Score = 80.5 bits (197), Expect = 2e-15
Identities = 61/244 (25%), Positives = 123/244 (50%), Gaps = 22/244 (9%)
Query: 38 ECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSE 97
E RA ++ ++ S++F ++ + N M + ++ L +LE + F S+ E
Sbjct: 593 ETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI-EHHEQPEELTNILEICNVVFTSMFALE 651
Query: 98 LSMKVYVDPI-NYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKL 156
+ +K+ + +Y +N YN+ D II+I+ ++ +++G+ L + + LR+LKL
Sbjct: 652 MILKLAAFGLFDYLRNPYNIFDSIIVII-----SIWEIVGQADGGLSVLRTFRLLRVLKL 706
Query: 157 IGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG-----SPDNG----DH 207
+ + +R + + +T+ VA+ +LL L ++IF+ILG +FG D G D
Sbjct: 707 VRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDR 766
Query: 208 DNWGNLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFILLASF---IFLNMFV 264
N+ +L A T+F + T + W + L N + S ++ F+ L +F + N+ V
Sbjct: 767 KNFDSLLWAIVTVFQILTQEDWNVV---LYNGMASTSPWASLYFVALMTFGNYVLFNLLV 823
Query: 265 GVMI 268
+++
Sbjct: 824 AILV 827
Score = 63.5 bits (153), Expect = 3e-10
Identities = 69/319 (21%), Positives = 135/319 (42%), Gaps = 53/319 (16%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMAL---WTSYDIRYRLFRLLEFSEIFFVS 92
++ R + +I + F ++++ + N +AL R+F L S F +
Sbjct: 1121 ENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIF--LTVSNYIFTA 1178
Query: 93 ICTSELSMKV-----YVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYI 144
I E+++KV Y Y ++ +N+LD ++ V + + K L +
Sbjct: 1179 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1238
Query: 145 ADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSP-- 202
+++LR L++I + G++ ++ + ++ + +++L+ IF ILG LF
Sbjct: 1239 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1298
Query: 203 -----------DNGD-----------HDNWGNLAAAFFTLFSLATVDGWTDL-------- 232
+ D N+ NL A +LF LA+ DGW ++
Sbjct: 1299 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV 1358
Query: 233 ---QKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQEM 289
Q+ + N + F I F+L+ SF LNMFVGV++ + + E E ++E
Sbjct: 1359 AVDQQPVTNHNPWMLLYF-ISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEK 1417
Query: 290 LMGEKQVILQRQQEEISRL 308
+ L++++ + RL
Sbjct: 1418 RLRR----LEKKRRKAQRL 1432
Score = 42.0 bits (97), Expect = 0.001
Identities = 20/88 (22%), Positives = 47/88 (53%), Gaps = 1/88 (1%)
Query: 209 NWGNLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMI 268
N+ N+ A+ +F + T++GW ++ + + + + I+ I++ SF +N+ + V+
Sbjct: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
Query: 269 MHTEDSIRKFERELMLEQQEMLMGEKQV 296
++ ++ E LMLEQ++ + V
Sbjct: 399 TQFSETKQR-EHRLMLEQRQRYLSSSTV 425
Score = 37.0 bits (84), Expect = 0.031
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 109 YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLIT 168
Y + +N LD I++ + Y+L Q L ++ LR LK I +R L+
Sbjct: 145 YLGDTWNRLDFFIVMAGMVEYSL----DLQNINLSAIRTVRVLRPLKAINRVPSMRILVN 200
Query: 169 AVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ T+ + +VLLL F + +IF I+G L+
Sbjct: 201 LLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform a [Homo sapiens]
Length = 2223
Score = 85.9 bits (211), Expect = 6e-17
Identities = 67/275 (24%), Positives = 130/275 (47%), Gaps = 29/275 (10%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
R + + S + I + + N M+L Y+ L L++ F ++ E
Sbjct: 1477 RLLIHSMCTSHYLDIFITFIICLNVVTMSL-EHYNQPTSLETALKYCNYMFTTVFVLEAV 1535
Query: 100 MKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYALRQL-----MGKQFTYLYIADGMQSLRI 153
+K+ + ++K+ +N LD+ I+++ + L ++ + T + I ++ R+
Sbjct: 1536 LKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARV 1595
Query: 154 LKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG-------SPDNG- 205
LKL+ + G+R L+ V Q + V ++ LL LL +I+A LG LFG +P G
Sbjct: 1596 LKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGM 1655
Query: 206 -DHDNWGNLAAAFFTLFSLATVDGWTDLQKQ------------LDNREFALSRAFTIIFI 252
H + N AF TLF ++T D W + K L + +F +S + + F+
Sbjct: 1656 SRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQF-VSPLYFVSFV 1714
Query: 253 LLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
L A F+ +N+ V V++ H +DS ++ + + ++ +
Sbjct: 1715 LTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAE 1749
Score = 80.5 bits (197), Expect = 2e-15
Identities = 61/244 (25%), Positives = 123/244 (50%), Gaps = 22/244 (9%)
Query: 38 ECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSE 97
E RA ++ ++ S++F ++ + N M + ++ L +LE + F S+ E
Sbjct: 628 ETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI-EHHEQPEELTNILEICNVVFTSMFALE 686
Query: 98 LSMKVYVDPI-NYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKL 156
+ +K+ + +Y +N YN+ D II+I+ ++ +++G+ L + + LR+LKL
Sbjct: 687 MILKLAAFGLFDYLRNPYNIFDSIIVII-----SIWEIVGQADGGLSVLRTFRLLRVLKL 741
Query: 157 IGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG-----SPDNG----DH 207
+ + +R + + +T+ VA+ +LL L ++IF+ILG +FG D G D
Sbjct: 742 VRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDR 801
Query: 208 DNWGNLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFILLASF---IFLNMFV 264
N+ +L A T+F + T + W + L N + S ++ F+ L +F + N+ V
Sbjct: 802 KNFDSLLWAIVTVFQILTQEDWNVV---LYNGMASTSPWASLYFVALMTFGNYVLFNLLV 858
Query: 265 GVMI 268
+++
Sbjct: 859 AILV 862
Score = 63.5 bits (153), Expect = 3e-10
Identities = 69/319 (21%), Positives = 135/319 (42%), Gaps = 53/319 (16%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMAL---WTSYDIRYRLFRLLEFSEIFFVS 92
++ R + +I + F ++++ + N +AL R+F L S F +
Sbjct: 1156 ENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIF--LTVSNYIFTA 1213
Query: 93 ICTSELSMKV-----YVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYI 144
I E+++KV Y Y ++ +N+LD ++ V + + K L +
Sbjct: 1214 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1273
Query: 145 ADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSP-- 202
+++LR L++I + G++ ++ + ++ + +++L+ IF ILG LF
Sbjct: 1274 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1333
Query: 203 -----------DNGD-----------HDNWGNLAAAFFTLFSLATVDGWTDL-------- 232
+ D N+ NL A +LF LA+ DGW ++
Sbjct: 1334 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV 1393
Query: 233 ---QKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQEM 289
Q+ + N + F I F+L+ SF LNMFVGV++ + + E E ++E
Sbjct: 1394 AVDQQPVTNHNPWMLLYF-ISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEK 1452
Query: 290 LMGEKQVILQRQQEEISRL 308
+ L++++ + RL
Sbjct: 1453 RLRR----LEKKRRKAQRL 1467
Score = 42.0 bits (97), Expect = 0.001
Identities = 20/88 (22%), Positives = 47/88 (53%), Gaps = 1/88 (1%)
Query: 209 NWGNLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMI 268
N+ N+ A+ +F + T++GW ++ + + + + I+ I++ SF +N+ + V+
Sbjct: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
Query: 269 MHTEDSIRKFERELMLEQQEMLMGEKQV 296
++ ++ E LMLEQ++ + V
Sbjct: 399 TQFSETKQR-EHRLMLEQRQRYLSSSTV 425
Score = 37.0 bits (84), Expect = 0.031
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 109 YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLIT 168
Y + +N LD I++ + Y+L Q L ++ LR LK I +R L+
Sbjct: 145 YLGDTWNRLDFFIVMAGMVEYSL----DLQNINLSAIRTVRVLRPLKAINRVPSMRILVN 200
Query: 169 AVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ T+ + +VLLL F + +IF I+G L+
Sbjct: 201 LLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
isoform 1 [Homo sapiens]
Length = 2377
Score = 85.5 bits (210), Expect = 8e-17
Identities = 70/279 (25%), Positives = 131/279 (46%), Gaps = 39/279 (13%)
Query: 6 HQRHSRVISSSPVDTTSVGF----CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVT 61
H R R + ++ + F C TF+K ++ S++F ++ +
Sbjct: 709 HSRRQRSLGPDAEPSSVLAFWRLICDTFRK--------------IVDSKYFGRGIMIAIL 754
Query: 62 SNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-DPINYWKNGYNLLDVI 120
N M + ++ L LE S I F S+ E+ +K+ V P Y KN YN+ D +
Sbjct: 755 VNTLSMGI-EYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGV 813
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
I+++ ++ +++G+Q L + + +R+LKL+ + ++ + + +T+ VA+
Sbjct: 814 IVVI-----SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
Query: 181 LLLLFLLMYIFAILGF----CLFGSPDNG----DHDNWGNLAAAFFTLFSLATVDGWTDL 232
+LL L ++IF+ILG C F S +G D N+ +L A T+F + T + W
Sbjct: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDW--- 925
Query: 233 QKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI 268
K L N + S + FI L +F + N+ V +++
Sbjct: 926 NKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Score = 84.7 bits (208), Expect = 1e-16
Identities = 72/299 (24%), Positives = 129/299 (43%), Gaps = 27/299 (9%)
Query: 12 VISSSPVDTTSVGFCPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWT 71
+ S S S C K + + R V + S + + + + N MA+
Sbjct: 1576 IASGSSASAASEAQC---KPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM-E 1631
Query: 72 SYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYA 130
Y L L+ F I E K+ ++++ +N LD+ I+++ +
Sbjct: 1632 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1691
Query: 131 LRQL-----MGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLF 185
L ++ + T + I ++ R+LKL+ + G+R L+ V Q + V ++ LL
Sbjct: 1692 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1751
Query: 186 LLMYIFAILGFCLFGSPD---------NGDHDNWGNLAAAFFTLFSLATVDGWT------ 230
LL +IFA LG LFG + G H + N AF TLF ++T D W
Sbjct: 1752 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1811
Query: 231 --DLQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
D ++ +S + + F+L A F+ +N+ + V++ H E+S ++ + E LE +
Sbjct: 1812 LRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1870
Score = 64.3 bits (155), Expect = 2e-10
Identities = 61/294 (20%), Positives = 128/294 (43%), Gaps = 47/294 (15%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRL-LEFSEIFFVSICTSEL 98
R R+I + F +++ + N +A+ + R+ L S F ++ +E+
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 99 SMKVYV-----DPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADGMQS 150
++KV Y ++ +N+LD +++++ + + + K L + +++
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF----------- 199
LR L++I +QG++ ++ + ++ + +++++ IF ILG LF
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1445
Query: 200 -----GSPDNGDHD--------NWGNLAAAFFTLFSLATVDGWTDL------------QK 234
D + N+ NL A +LF LA+ DGW D+ Q
Sbjct: 1446 TRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQP 1505
Query: 235 QLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQE 288
+++ + L + I F+L+ +F LNMFVGV++ + + E E ++E
Sbjct: 1506 IMNHNPWML--LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 11/171 (6%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYD---IRYRLFRLLEFSEIFFVS 92
D R++ R + + +F+ I + + N + ++ + + R+L+ + F +
Sbjct: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 93 ICTSELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E+ +K+ I Y + +N LD I+I L Y+L L F+ + +
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRT---V 182
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ LR L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 183 RVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
>gi|38505294 voltage-dependent calcium channel alpha 1G subunit
isoform 15 [Homo sapiens]
Length = 1555
Score = 85.5 bits (210), Expect = 8e-17
Identities = 70/279 (25%), Positives = 131/279 (46%), Gaps = 39/279 (13%)
Query: 6 HQRHSRVISSSPVDTTSVGF----CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVT 61
H R R + ++ + F C TF+K ++ S++F ++ +
Sbjct: 709 HSRRQRSLGPDAEPSSVLAFWRLICDTFRK--------------IVDSKYFGRGIMIAIL 754
Query: 62 SNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-DPINYWKNGYNLLDVI 120
N M + ++ L LE S I F S+ E+ +K+ V P Y KN YN+ D +
Sbjct: 755 VNTLSMGI-EYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGV 813
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
I+++ ++ +++G+Q L + + +R+LKL+ + ++ + + +T+ VA+
Sbjct: 814 IVVI-----SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
Query: 181 LLLLFLLMYIFAILGF----CLFGSPDNG----DHDNWGNLAAAFFTLFSLATVDGWTDL 232
+LL L ++IF+ILG C F S +G D N+ +L A T+F + T + W
Sbjct: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDW--- 925
Query: 233 QKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI 268
K L N + S + FI L +F + N+ V +++
Sbjct: 926 NKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Score = 42.7 bits (99), Expect = 6e-04
Identities = 32/169 (18%), Positives = 80/169 (47%), Gaps = 9/169 (5%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRL-LEFSEIFFVSICTSEL 98
R R+I + F +++ + N +A+ + R+ L S F ++ +E+
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 99 SMKVYV-----DPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADGMQS 150
++KV Y ++ +N+LD +++++ + + + K L + +++
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
LR L++I +QG++ ++ + ++ + +++++ IF ILG LF
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 11/171 (6%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYD---IRYRLFRLLEFSEIFFVS 92
D R++ R + + +F+ I + + N + ++ + + R+L+ + F +
Sbjct: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 93 ICTSELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E+ +K+ I Y + +N LD I+I L Y+L L F+ + +
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRT---V 182
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ LR L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 183 RVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
isoform 10 [Homo sapiens]
Length = 2266
Score = 85.5 bits (210), Expect = 8e-17
Identities = 70/279 (25%), Positives = 131/279 (46%), Gaps = 39/279 (13%)
Query: 6 HQRHSRVISSSPVDTTSVGF----CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVT 61
H R R + ++ + F C TF+K ++ S++F ++ +
Sbjct: 709 HSRRQRSLGPDAEPSSVLAFWRLICDTFRK--------------IVDSKYFGRGIMIAIL 754
Query: 62 SNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-DPINYWKNGYNLLDVI 120
N M + ++ L LE S I F S+ E+ +K+ V P Y KN YN+ D +
Sbjct: 755 VNTLSMGI-EYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGV 813
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
I+++ ++ +++G+Q L + + +R+LKL+ + ++ + + +T+ VA+
Sbjct: 814 IVVI-----SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
Query: 181 LLLLFLLMYIFAILGF----CLFGSPDNG----DHDNWGNLAAAFFTLFSLATVDGWTDL 232
+LL L ++IF+ILG C F S +G D N+ +L A T+F + T + W
Sbjct: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDW--- 925
Query: 233 QKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI 268
K L N + S + FI L +F + N+ V +++
Sbjct: 926 NKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Score = 83.6 bits (205), Expect = 3e-16
Identities = 67/271 (24%), Positives = 121/271 (44%), Gaps = 24/271 (8%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
R V + S + + + + N MA+ Y L L+ F I E
Sbjct: 1583 RLLVHHLCTSHYLDLFITGVIGLNVVTMAM-EHYQQPQILDEALKICNYIFTVIFVLESV 1641
Query: 100 MKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYALRQL-----MGKQFTYLYIADGMQSLRI 153
K+ ++++ +N LD+ I+++ + L ++ + T + I ++ R+
Sbjct: 1642 FKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARV 1701
Query: 154 LKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPD---------N 204
LKL+ + G+R L+ V Q + V ++ LL LL +IFA LG LFG +
Sbjct: 1702 LKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGL 1761
Query: 205 GDHDNWGNLAAAFFTLFSLATVDGWT--------DLQKQLDNREFALSRAFTIIFILLAS 256
G H + N AF TLF ++T D W D ++ +S + + F+L A
Sbjct: 1762 GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1821
Query: 257 FIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
F+ +N+ + V++ H E+S ++ + E LE +
Sbjct: 1822 FVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1852
Score = 67.8 bits (164), Expect = 2e-11
Identities = 67/339 (19%), Positives = 145/339 (42%), Gaps = 61/339 (17%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRL-LEFSEIFFVSICTSEL 98
R R+I + F +++ + N +A+ + R+ L S F ++ +E+
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 99 SMKVYV-----DPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADGMQS 150
++KV Y ++ +N+LD +++++ + + + K L + +++
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF----------- 199
LR L++I +QG++ ++ + ++ + +++++ IF ILG LF
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1445
Query: 200 -----GSPDNGDHD--------NWGNLAAAFFTLFSLATVDGWTDL------------QK 234
D + N+ NL A +LF LA+ DGW D+ Q
Sbjct: 1446 TRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQP 1505
Query: 235 QLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQEMLMGEK 294
+++ + L + I F+L+ +F LNMFVGV++ ++ K + E+
Sbjct: 1506 IMNHNPWML--LYFISFLLIVAFFVLNMFVGVVV----ENFHKCRQH----------QEE 1549
Query: 295 QVILQRQQEEISRLMHIQKNADCTSFSELVENFKKTLSH 333
+ +R+++ + RL ++ A C + F+ + H
Sbjct: 1550 EEARRREEKRLRRLEKKRRKAQCKPYYSDYSRFRLLVHH 1588
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 11/171 (6%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYD---IRYRLFRLLEFSEIFFVS 92
D R++ R + + +F+ I + + N + ++ + + R+L+ + F +
Sbjct: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 93 ICTSELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E+ +K+ I Y + +N LD I+I L Y+L L F+ + +
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRT---V 182
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ LR L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 183 RVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
isoform 4 [Homo sapiens]
Length = 2332
Score = 85.5 bits (210), Expect = 8e-17
Identities = 70/279 (25%), Positives = 131/279 (46%), Gaps = 39/279 (13%)
Query: 6 HQRHSRVISSSPVDTTSVGF----CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVT 61
H R R + ++ + F C TF+K ++ S++F ++ +
Sbjct: 709 HSRRQRSLGPDAEPSSVLAFWRLICDTFRK--------------IVDSKYFGRGIMIAIL 754
Query: 62 SNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-DPINYWKNGYNLLDVI 120
N M + ++ L LE S I F S+ E+ +K+ V P Y KN YN+ D +
Sbjct: 755 VNTLSMGI-EYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGV 813
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
I+++ ++ +++G+Q L + + +R+LKL+ + ++ + + +T+ VA+
Sbjct: 814 IVVI-----SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
Query: 181 LLLLFLLMYIFAILGF----CLFGSPDNG----DHDNWGNLAAAFFTLFSLATVDGWTDL 232
+LL L ++IF+ILG C F S +G D N+ +L A T+F + T + W
Sbjct: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDW--- 925
Query: 233 QKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI 268
K L N + S + FI L +F + N+ V +++
Sbjct: 926 NKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Score = 84.7 bits (208), Expect = 1e-16
Identities = 72/299 (24%), Positives = 129/299 (43%), Gaps = 27/299 (9%)
Query: 12 VISSSPVDTTSVGFCPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWT 71
+ S S S C K + + R V + S + + + + N MA+
Sbjct: 1576 IASGSSASAASEAQC---KPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM-E 1631
Query: 72 SYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYA 130
Y L L+ F I E K+ ++++ +N LD+ I+++ +
Sbjct: 1632 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1691
Query: 131 LRQL-----MGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLF 185
L ++ + T + I ++ R+LKL+ + G+R L+ V Q + V ++ LL
Sbjct: 1692 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1751
Query: 186 LLMYIFAILGFCLFGSPD---------NGDHDNWGNLAAAFFTLFSLATVDGWT------ 230
LL +IFA LG LFG + G H + N AF TLF ++T D W
Sbjct: 1752 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1811
Query: 231 --DLQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
D ++ +S + + F+L A F+ +N+ + V++ H E+S ++ + E LE +
Sbjct: 1812 LRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1870
Score = 64.3 bits (155), Expect = 2e-10
Identities = 61/294 (20%), Positives = 128/294 (43%), Gaps = 47/294 (15%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRL-LEFSEIFFVSICTSEL 98
R R+I + F +++ + N +A+ + R+ L S F ++ +E+
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 99 SMKVYV-----DPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADGMQS 150
++KV Y ++ +N+LD +++++ + + + K L + +++
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF----------- 199
LR L++I +QG++ ++ + ++ + +++++ IF ILG LF
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1445
Query: 200 -----GSPDNGDHD--------NWGNLAAAFFTLFSLATVDGWTDL------------QK 234
D + N+ NL A +LF LA+ DGW D+ Q
Sbjct: 1446 TRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQP 1505
Query: 235 QLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQE 288
+++ + L + I F+L+ +F LNMFVGV++ + + E E ++E
Sbjct: 1506 IMNHNPWML--LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 11/171 (6%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYD---IRYRLFRLLEFSEIFFVS 92
D R++ R + + +F+ I + + N + ++ + + R+L+ + F +
Sbjct: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 93 ICTSELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E+ +K+ I Y + +N LD I+I L Y+L L F+ + +
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRT---V 182
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ LR L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 183 RVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
isoform 8 [Homo sapiens]
Length = 2284
Score = 85.5 bits (210), Expect = 8e-17
Identities = 70/279 (25%), Positives = 131/279 (46%), Gaps = 39/279 (13%)
Query: 6 HQRHSRVISSSPVDTTSVGF----CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVT 61
H R R + ++ + F C TF+K ++ S++F ++ +
Sbjct: 709 HSRRQRSLGPDAEPSSVLAFWRLICDTFRK--------------IVDSKYFGRGIMIAIL 754
Query: 62 SNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-DPINYWKNGYNLLDVI 120
N M + ++ L LE S I F S+ E+ +K+ V P Y KN YN+ D +
Sbjct: 755 VNTLSMGI-EYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGV 813
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
I+++ ++ +++G+Q L + + +R+LKL+ + ++ + + +T+ VA+
Sbjct: 814 IVVI-----SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
Query: 181 LLLLFLLMYIFAILGF----CLFGSPDNG----DHDNWGNLAAAFFTLFSLATVDGWTDL 232
+LL L ++IF+ILG C F S +G D N+ +L A T+F + T + W
Sbjct: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDW--- 925
Query: 233 QKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI 268
K L N + S + FI L +F + N+ V +++
Sbjct: 926 NKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Score = 84.7 bits (208), Expect = 1e-16
Identities = 72/299 (24%), Positives = 129/299 (43%), Gaps = 27/299 (9%)
Query: 12 VISSSPVDTTSVGFCPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWT 71
+ S S S C K + + R V + S + + + + N MA+
Sbjct: 1576 IASGSSASAASEAQC---KPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM-E 1631
Query: 72 SYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYA 130
Y L L+ F I E K+ ++++ +N LD+ I+++ +
Sbjct: 1632 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1691
Query: 131 LRQL-----MGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLF 185
L ++ + T + I ++ R+LKL+ + G+R L+ V Q + V ++ LL
Sbjct: 1692 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1751
Query: 186 LLMYIFAILGFCLFGSPD---------NGDHDNWGNLAAAFFTLFSLATVDGWT------ 230
LL +IFA LG LFG + G H + N AF TLF ++T D W
Sbjct: 1752 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1811
Query: 231 --DLQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
D ++ +S + + F+L A F+ +N+ + V++ H E+S ++ + E LE +
Sbjct: 1812 LRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1870
Score = 64.3 bits (155), Expect = 2e-10
Identities = 61/294 (20%), Positives = 128/294 (43%), Gaps = 47/294 (15%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRL-LEFSEIFFVSICTSEL 98
R R+I + F +++ + N +A+ + R+ L S F ++ +E+
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 99 SMKVYV-----DPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADGMQS 150
++KV Y ++ +N+LD +++++ + + + K L + +++
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF----------- 199
LR L++I +QG++ ++ + ++ + +++++ IF ILG LF
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1445
Query: 200 -----GSPDNGDHD--------NWGNLAAAFFTLFSLATVDGWTDL------------QK 234
D + N+ NL A +LF LA+ DGW D+ Q
Sbjct: 1446 TRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQP 1505
Query: 235 QLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQE 288
+++ + L + I F+L+ +F LNMFVGV++ + + E E ++E
Sbjct: 1506 IMNHNPWML--LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 11/171 (6%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYD---IRYRLFRLLEFSEIFFVS 92
D R++ R + + +F+ I + + N + ++ + + R+L+ + F +
Sbjct: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 93 ICTSELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E+ +K+ I Y + +N LD I+I L Y+L L F+ + +
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRT---V 182
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ LR L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 183 RVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
isoform 5 [Homo sapiens]
Length = 2321
Score = 85.5 bits (210), Expect = 8e-17
Identities = 70/279 (25%), Positives = 131/279 (46%), Gaps = 39/279 (13%)
Query: 6 HQRHSRVISSSPVDTTSVGF----CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVT 61
H R R + ++ + F C TF+K ++ S++F ++ +
Sbjct: 709 HSRRQRSLGPDAEPSSVLAFWRLICDTFRK--------------IVDSKYFGRGIMIAIL 754
Query: 62 SNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-DPINYWKNGYNLLDVI 120
N M + ++ L LE S I F S+ E+ +K+ V P Y KN YN+ D +
Sbjct: 755 VNTLSMGI-EYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGV 813
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
I+++ ++ +++G+Q L + + +R+LKL+ + ++ + + +T+ VA+
Sbjct: 814 IVVI-----SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
Query: 181 LLLLFLLMYIFAILGF----CLFGSPDNG----DHDNWGNLAAAFFTLFSLATVDGWTDL 232
+LL L ++IF+ILG C F S +G D N+ +L A T+F + T + W
Sbjct: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDW--- 925
Query: 233 QKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI 268
K L N + S + FI L +F + N+ V +++
Sbjct: 926 NKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Score = 83.6 bits (205), Expect = 3e-16
Identities = 67/271 (24%), Positives = 121/271 (44%), Gaps = 24/271 (8%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
R V + S + + + + N MA+ Y L L+ F I E
Sbjct: 1590 RLLVHHLCTSHYLDLFITGVIGLNVVTMAM-EHYQQPQILDEALKICNYIFTVIFVLESV 1648
Query: 100 MKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYALRQL-----MGKQFTYLYIADGMQSLRI 153
K+ ++++ +N LD+ I+++ + L ++ + T + I ++ R+
Sbjct: 1649 FKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARV 1708
Query: 154 LKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPD---------N 204
LKL+ + G+R L+ V Q + V ++ LL LL +IFA LG LFG +
Sbjct: 1709 LKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGL 1768
Query: 205 GDHDNWGNLAAAFFTLFSLATVDGWT--------DLQKQLDNREFALSRAFTIIFILLAS 256
G H + N AF TLF ++T D W D ++ +S + + F+L A
Sbjct: 1769 GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1828
Query: 257 FIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
F+ +N+ + V++ H E+S ++ + E LE +
Sbjct: 1829 FVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1859
Score = 66.6 bits (161), Expect = 4e-11
Identities = 65/311 (20%), Positives = 136/311 (43%), Gaps = 56/311 (18%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRL-LEFSEIFFVSICTSEL 98
R R+I + F +++ + N +A+ + R+ L S F ++ +E+
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 99 SMKVYV-----DPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADGMQS 150
++KV Y ++ +N+LD +++++ + + + K L + +++
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF----------- 199
LR L++I +QG++ ++ + ++ + +++++ IF ILG LF
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1445
Query: 200 -----GSPDNGDHD--------NWGNLAAAFFTLFSLATVDGWTDL------------QK 234
D + N+ NL A +LF LA+ DGW D+ Q
Sbjct: 1446 TRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQP 1505
Query: 235 QLDNREFALSRAFTIIFILLASFIFLNMFVGVMI---------MHTEDSIRKFERELMLE 285
+++ + L + I F+L+ +F LNMFVGV++ E++ R+ E+ L
Sbjct: 1506 IMNHNPWML--LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1563
Query: 286 QQEMLMGEKQV 296
+++ EKQ+
Sbjct: 1564 EKKRRSKEKQM 1574
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 11/171 (6%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYD---IRYRLFRLLEFSEIFFVS 92
D R++ R + + +F+ I + + N + ++ + + R+L+ + F +
Sbjct: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 93 ICTSELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E+ +K+ I Y + +N LD I+I L Y+L L F+ + +
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRT---V 182
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ LR L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 183 RVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
isoform 9 [Homo sapiens]
Length = 2273
Score = 85.5 bits (210), Expect = 8e-17
Identities = 70/279 (25%), Positives = 131/279 (46%), Gaps = 39/279 (13%)
Query: 6 HQRHSRVISSSPVDTTSVGF----CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVT 61
H R R + ++ + F C TF+K ++ S++F ++ +
Sbjct: 709 HSRRQRSLGPDAEPSSVLAFWRLICDTFRK--------------IVDSKYFGRGIMIAIL 754
Query: 62 SNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYV-DPINYWKNGYNLLDVI 120
N M + ++ L LE S I F S+ E+ +K+ V P Y KN YN+ D +
Sbjct: 755 VNTLSMGI-EYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGV 813
Query: 121 IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV 180
I+++ ++ +++G+Q L + + +R+LKL+ + ++ + + +T+ VA+
Sbjct: 814 IVVI-----SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF 868
Query: 181 LLLLFLLMYIFAILGF----CLFGSPDNG----DHDNWGNLAAAFFTLFSLATVDGWTDL 232
+LL L ++IF+ILG C F S +G D N+ +L A T+F + T + W
Sbjct: 869 CMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDW--- 925
Query: 233 QKQLDNREFALSRAFTIIFILLASF---IFLNMFVGVMI 268
K L N + S + FI L +F + N+ V +++
Sbjct: 926 NKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Score = 83.6 bits (205), Expect = 3e-16
Identities = 67/271 (24%), Positives = 121/271 (44%), Gaps = 24/271 (8%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELS 99
R V + S + + + + N MA+ Y L L+ F I E
Sbjct: 1590 RLLVHHLCTSHYLDLFITGVIGLNVVTMAM-EHYQQPQILDEALKICNYIFTVIFVLESV 1648
Query: 100 MKVYVDPIN-YWKNGYNLLDVIIIIVMFLPYALRQL-----MGKQFTYLYIADGMQSLRI 153
K+ ++++ +N LD+ I+++ + L ++ + T + I ++ R+
Sbjct: 1649 FKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARV 1708
Query: 154 LKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPD---------N 204
LKL+ + G+R L+ V Q + V ++ LL LL +IFA LG LFG +
Sbjct: 1709 LKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGL 1768
Query: 205 GDHDNWGNLAAAFFTLFSLATVDGWT--------DLQKQLDNREFALSRAFTIIFILLAS 256
G H + N AF TLF ++T D W D ++ +S + + F+L A
Sbjct: 1769 GRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1828
Query: 257 FIFLNMFVGVMIMHTEDSIRKFERELMLEQQ 287
F+ +N+ + V++ H E+S ++ + E LE +
Sbjct: 1829 FVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1859
Score = 66.6 bits (161), Expect = 4e-11
Identities = 65/311 (20%), Positives = 136/311 (43%), Gaps = 56/311 (18%)
Query: 40 RAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRL-LEFSEIFFVSICTSEL 98
R R+I + F +++ + N +A+ + R+ L S F ++ +E+
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 99 SMKVYV-----DPINYWKNGYNLLDVIIIIVMFLPYALRQLMG---KQFTYLYIADGMQS 150
++KV Y ++ +N+LD +++++ + + + K L + +++
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 151 LRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF----------- 199
LR L++I +QG++ ++ + ++ + +++++ IF ILG LF
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1445
Query: 200 -----GSPDNGDHD--------NWGNLAAAFFTLFSLATVDGWTDL------------QK 234
D + N+ NL A +LF LA+ DGW D+ Q
Sbjct: 1446 TRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQP 1505
Query: 235 QLDNREFALSRAFTIIFILLASFIFLNMFVGVMI---------MHTEDSIRKFERELMLE 285
+++ + L + I F+L+ +F LNMFVGV++ E++ R+ E+ L
Sbjct: 1506 IMNHNPWML--LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1563
Query: 286 QQEMLMGEKQV 296
+++ EKQ+
Sbjct: 1564 EKKRRSKEKQM 1574
Score = 42.4 bits (98), Expect = 7e-04
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 11/171 (6%)
Query: 36 DDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYD---IRYRLFRLLEFSEIFFVS 92
D R++ R + + +F+ I + + N + ++ + + R+L+ + F +
Sbjct: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
Query: 93 ICTSELSMKVYVDPIN----YWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGM 148
E+ +K+ I Y + +N LD I+I L Y+L L F+ + +
Sbjct: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL-DLQNVSFSAVRT---V 182
Query: 149 QSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF 199
+ LR L+ I +R L+T + T+ + +VLLL F + +IF I+G L+
Sbjct: 183 RVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
>gi|237512982 voltage-gated sodium channel type V alpha isoform f
[Homo sapiens]
Length = 1962
Score = 84.0 bits (206), Expect = 2e-16
Identities = 63/256 (24%), Positives = 123/256 (48%), Gaps = 29/256 (11%)
Query: 26 CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEF 85
CP + K+ VK V+M F + + + N FMAL Y++ +L+
Sbjct: 700 CPLWMSIKQG-------VKLVVMDPFTDLTITMCIVLNTLFMAL-EHYNMTSEFEEMLQV 751
Query: 86 SEIFFVSICTSELSMKVY-VDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYI 144
+ F I T+E++ K+ +DP Y++ G+N+ D II+I+ + L ++ L +
Sbjct: 752 GNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSN-----LSV 806
Query: 145 ADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG---- 200
+ LR+ KL + TLI +G +V + ++ L+L ++++IFA++G LFG
Sbjct: 807 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
Query: 201 ---SPDNGDHDNWG--NLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFIL-- 253
D+G W + AF +F + + W ++ D E + ++F+L
Sbjct: 867 ELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE-W--IETMWDCMEVSGQSLCLLVFLLVM 923
Query: 254 -LASFIFLNMFVGVMI 268
+ + + LN+F+ +++
Sbjct: 924 VIGNLVVLNLFLALLL 939
Score = 72.8 bits (177), Expect = 5e-13
Identities = 61/266 (22%), Positives = 119/266 (44%), Gaps = 28/266 (10%)
Query: 30 KKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIF 89
K R ++ + F+ ++ + F + ++ + N M + T D +L +
Sbjct: 1454 KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETD-DQSPEKINILAKINLL 1512
Query: 90 FVSICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQF---TYLYIAD 146
FV+I T E +K+ Y+ N +N+ D +++I+ + L ++ K F T +
Sbjct: 1513 FVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIR 1572
Query: 147 GMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG----SP 202
+ RIL+LI ++GIRTL+ A+ ++ + ++ LLLFL+M+I++I G F
Sbjct: 1573 LARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEA 1632
Query: 203 DNGDHDNWGNLAAAFFTLFSLATVDGWTDLQKQL--------------------DNREFA 242
D N+ A + LF + T GW L + D A
Sbjct: 1633 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPA 1692
Query: 243 LSRAFTIIFILLASFIFLNMFVGVMI 268
+ F +I+++ I +NM++ +++
Sbjct: 1693 VGILFFTTYIIISFLIVVNMYIAIIL 1718
Score = 62.0 bits (149), Expect = 9e-10
Identities = 59/260 (22%), Positives = 110/260 (42%), Gaps = 52/260 (20%)
Query: 82 LLEFSEIFFVSICTSELSMK-VYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFT 140
LLE+++ F + E+ +K V Y+ N + LD +I+ V + L +
Sbjct: 1184 LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 1243
Query: 141 YLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG 200
+ +++LR L+ + +G+R ++ A+ + ++ +VLL+ + IF+I+G LF
Sbjct: 1244 PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1303
Query: 201 -------SPDNGD----------------------------HDNWGNLAAAFFTLFSLAT 225
+ GD N+ N+ A + L +AT
Sbjct: 1304 GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1363
Query: 226 VDGWTDLQ-KQLDNREF---------ALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSI 275
GW D+ +D+R + + +IFI+ SF LN+F+GV+I +
Sbjct: 1364 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1423
Query: 276 RKFERELMLEQQEMLMGEKQ 295
+K L Q++ M E+Q
Sbjct: 1424 KK------LGGQDIFMTEEQ 1437
>gi|237512980 voltage-gated sodium channel type V alpha isoform e
[Homo sapiens]
Length = 1983
Score = 84.0 bits (206), Expect = 2e-16
Identities = 63/256 (24%), Positives = 123/256 (48%), Gaps = 29/256 (11%)
Query: 26 CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEF 85
CP + K+ VK V+M F + + + N FMAL Y++ +L+
Sbjct: 700 CPLWMSIKQG-------VKLVVMDPFTDLTITMCIVLNTLFMAL-EHYNMTSEFEEMLQV 751
Query: 86 SEIFFVSICTSELSMKVY-VDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYI 144
+ F I T+E++ K+ +DP Y++ G+N+ D II+I+ + L ++ L +
Sbjct: 752 GNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSN-----LSV 806
Query: 145 ADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG---- 200
+ LR+ KL + TLI +G +V + ++ L+L ++++IFA++G LFG
Sbjct: 807 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
Query: 201 ---SPDNGDHDNWG--NLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFIL-- 253
D+G W + AF +F + + W ++ D E + ++F+L
Sbjct: 867 ELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE-W--IETMWDCMEVSGQSLCLLVFLLVM 923
Query: 254 -LASFIFLNMFVGVMI 268
+ + + LN+F+ +++
Sbjct: 924 VIGNLVVLNLFLALLL 939
Score = 62.0 bits (149), Expect = 9e-10
Identities = 59/260 (22%), Positives = 110/260 (42%), Gaps = 52/260 (20%)
Query: 82 LLEFSEIFFVSICTSELSMK-VYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFT 140
LLE+++ F + E+ +K V Y+ N + LD +I+ V + L +
Sbjct: 1237 LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 1296
Query: 141 YLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG 200
+ +++LR L+ + +G+R ++ A+ + ++ +VLL+ + IF+I+G LF
Sbjct: 1297 PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1356
Query: 201 -------SPDNGD----------------------------HDNWGNLAAAFFTLFSLAT 225
+ GD N+ N+ A + L +AT
Sbjct: 1357 GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1416
Query: 226 VDGWTDLQ-KQLDNREF---------ALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSI 275
GW D+ +D+R + + +IFI+ SF LN+F+GV+I +
Sbjct: 1417 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1476
Query: 276 RKFERELMLEQQEMLMGEKQ 295
+K L Q++ M E+Q
Sbjct: 1477 KK------LGGQDIFMTEEQ 1490
Score = 53.1 bits (126), Expect = 4e-07
Identities = 48/203 (23%), Positives = 89/203 (43%), Gaps = 27/203 (13%)
Query: 93 ICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQF---TYLYIADGMQ 149
IC + ++M V D + K ++ + +F L ++ K F T + +
Sbjct: 1537 ICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGTVLSDIIQKYFFSPTLFRVIRLAR 1596
Query: 150 SLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG----SPDNG 205
RIL+LI ++GIRTL+ A+ ++ + ++ LLLFL+M+I++I G F
Sbjct: 1597 IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGID 1656
Query: 206 DHDNWGNLAAAFFTLFSLATVDGWTDLQKQL--------------------DNREFALSR 245
D N+ A + LF + T GW L + D A+
Sbjct: 1657 DMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGI 1716
Query: 246 AFTIIFILLASFIFLNMFVGVMI 268
F +I+++ I +NM++ +++
Sbjct: 1717 LFFTTYIIISFLIVVNMYIAIIL 1739
>gi|37622907 voltage-gated sodium channel type V alpha isoform a
[Homo sapiens]
Length = 2016
Score = 84.0 bits (206), Expect = 2e-16
Identities = 63/256 (24%), Positives = 123/256 (48%), Gaps = 29/256 (11%)
Query: 26 CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEF 85
CP + K+ VK V+M F + + + N FMAL Y++ +L+
Sbjct: 700 CPLWMSIKQG-------VKLVVMDPFTDLTITMCIVLNTLFMAL-EHYNMTSEFEEMLQV 751
Query: 86 SEIFFVSICTSELSMKVY-VDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYI 144
+ F I T+E++ K+ +DP Y++ G+N+ D II+I+ + L ++ L +
Sbjct: 752 GNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSN-----LSV 806
Query: 145 ADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG---- 200
+ LR+ KL + TLI +G +V + ++ L+L ++++IFA++G LFG
Sbjct: 807 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
Query: 201 ---SPDNGDHDNWG--NLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFIL-- 253
D+G W + AF +F + + W ++ D E + ++F+L
Sbjct: 867 ELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE-W--IETMWDCMEVSGQSLCLLVFLLVM 923
Query: 254 -LASFIFLNMFVGVMI 268
+ + + LN+F+ +++
Sbjct: 924 VIGNLVVLNLFLALLL 939
Score = 72.8 bits (177), Expect = 5e-13
Identities = 61/266 (22%), Positives = 119/266 (44%), Gaps = 28/266 (10%)
Query: 30 KKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIF 89
K R ++ + F+ ++ + F + ++ + N M + T D +L +
Sbjct: 1508 KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETD-DQSPEKINILAKINLL 1566
Query: 90 FVSICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQF---TYLYIAD 146
FV+I T E +K+ Y+ N +N+ D +++I+ + L ++ K F T +
Sbjct: 1567 FVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIR 1626
Query: 147 GMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG----SP 202
+ RIL+LI ++GIRTL+ A+ ++ + ++ LLLFL+M+I++I G F
Sbjct: 1627 LARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEA 1686
Query: 203 DNGDHDNWGNLAAAFFTLFSLATVDGWTDLQKQL--------------------DNREFA 242
D N+ A + LF + T GW L + D A
Sbjct: 1687 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPA 1746
Query: 243 LSRAFTIIFILLASFIFLNMFVGVMI 268
+ F +I+++ I +NM++ +++
Sbjct: 1747 VGILFFTTYIIISFLIVVNMYIAIIL 1772
Score = 62.0 bits (149), Expect = 9e-10
Identities = 59/260 (22%), Positives = 110/260 (42%), Gaps = 52/260 (20%)
Query: 82 LLEFSEIFFVSICTSELSMK-VYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFT 140
LLE+++ F + E+ +K V Y+ N + LD +I+ V + L +
Sbjct: 1238 LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 1297
Query: 141 YLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG 200
+ +++LR L+ + +G+R ++ A+ + ++ +VLL+ + IF+I+G LF
Sbjct: 1298 PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1357
Query: 201 -------SPDNGD----------------------------HDNWGNLAAAFFTLFSLAT 225
+ GD N+ N+ A + L +AT
Sbjct: 1358 GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1417
Query: 226 VDGWTDLQ-KQLDNREF---------ALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSI 275
GW D+ +D+R + + +IFI+ SF LN+F+GV+I +
Sbjct: 1418 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1477
Query: 276 RKFERELMLEQQEMLMGEKQ 295
+K L Q++ M E+Q
Sbjct: 1478 KK------LGGQDIFMTEEQ 1491
>gi|30089970 voltage-gated sodium channel type V alpha isoform b
[Homo sapiens]
Length = 2015
Score = 84.0 bits (206), Expect = 2e-16
Identities = 63/256 (24%), Positives = 123/256 (48%), Gaps = 29/256 (11%)
Query: 26 CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEF 85
CP + K+ VK V+M F + + + N FMAL Y++ +L+
Sbjct: 700 CPLWMSIKQG-------VKLVVMDPFTDLTITMCIVLNTLFMAL-EHYNMTSEFEEMLQV 751
Query: 86 SEIFFVSICTSELSMKVY-VDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYI 144
+ F I T+E++ K+ +DP Y++ G+N+ D II+I+ + L ++ L +
Sbjct: 752 GNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSN-----LSV 806
Query: 145 ADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG---- 200
+ LR+ KL + TLI +G +V + ++ L+L ++++IFA++G LFG
Sbjct: 807 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
Query: 201 ---SPDNGDHDNWG--NLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFIL-- 253
D+G W + AF +F + + W ++ D E + ++F+L
Sbjct: 867 ELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE-W--IETMWDCMEVSGQSLCLLVFLLVM 923
Query: 254 -LASFIFLNMFVGVMI 268
+ + + LN+F+ +++
Sbjct: 924 VIGNLVVLNLFLALLL 939
Score = 72.8 bits (177), Expect = 5e-13
Identities = 61/266 (22%), Positives = 119/266 (44%), Gaps = 28/266 (10%)
Query: 30 KKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIF 89
K R ++ + F+ ++ + F + ++ + N M + T D +L +
Sbjct: 1507 KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETD-DQSPEKINILAKINLL 1565
Query: 90 FVSICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQF---TYLYIAD 146
FV+I T E +K+ Y+ N +N+ D +++I+ + L ++ K F T +
Sbjct: 1566 FVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIR 1625
Query: 147 GMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG----SP 202
+ RIL+LI ++GIRTL+ A+ ++ + ++ LLLFL+M+I++I G F
Sbjct: 1626 LARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEA 1685
Query: 203 DNGDHDNWGNLAAAFFTLFSLATVDGWTDLQKQL--------------------DNREFA 242
D N+ A + LF + T GW L + D A
Sbjct: 1686 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPA 1745
Query: 243 LSRAFTIIFILLASFIFLNMFVGVMI 268
+ F +I+++ I +NM++ +++
Sbjct: 1746 VGILFFTTYIIISFLIVVNMYIAIIL 1771
Score = 62.0 bits (149), Expect = 9e-10
Identities = 59/260 (22%), Positives = 110/260 (42%), Gaps = 52/260 (20%)
Query: 82 LLEFSEIFFVSICTSELSMK-VYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFT 140
LLE+++ F + E+ +K V Y+ N + LD +I+ V + L +
Sbjct: 1237 LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 1296
Query: 141 YLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG 200
+ +++LR L+ + +G+R ++ A+ + ++ +VLL+ + IF+I+G LF
Sbjct: 1297 PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1356
Query: 201 -------SPDNGD----------------------------HDNWGNLAAAFFTLFSLAT 225
+ GD N+ N+ A + L +AT
Sbjct: 1357 GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1416
Query: 226 VDGWTDLQ-KQLDNREF---------ALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSI 275
GW D+ +D+R + + +IFI+ SF LN+F+GV+I +
Sbjct: 1417 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1476
Query: 276 RKFERELMLEQQEMLMGEKQ 295
+K L Q++ M E+Q
Sbjct: 1477 KK------LGGQDIFMTEEQ 1490
>gi|150417969 voltage-gated sodium channel type V alpha isoform d
[Homo sapiens]
Length = 1998
Score = 84.0 bits (206), Expect = 2e-16
Identities = 63/256 (24%), Positives = 123/256 (48%), Gaps = 29/256 (11%)
Query: 26 CPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEF 85
CP + K+ VK V+M F + + + N FMAL Y++ +L+
Sbjct: 700 CPLWMSIKQG-------VKLVVMDPFTDLTITMCIVLNTLFMAL-EHYNMTSEFEEMLQV 751
Query: 86 SEIFFVSICTSELSMKVY-VDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYI 144
+ F I T+E++ K+ +DP Y++ G+N+ D II+I+ + L ++ L +
Sbjct: 752 GNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSN-----LSV 806
Query: 145 ADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG---- 200
+ LR+ KL + TLI +G +V + ++ L+L ++++IFA++G LFG
Sbjct: 807 LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
Query: 201 ---SPDNGDHDNWG--NLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFIL-- 253
D+G W + AF +F + + W ++ D E + ++F+L
Sbjct: 867 ELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE-W--IETMWDCMEVSGQSLCLLVFLLVM 923
Query: 254 -LASFIFLNMFVGVMI 268
+ + + LN+F+ +++
Sbjct: 924 VIGNLVVLNLFLALLL 939
Score = 72.8 bits (177), Expect = 5e-13
Identities = 61/266 (22%), Positives = 119/266 (44%), Gaps = 28/266 (10%)
Query: 30 KKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIF 89
K R ++ + F+ ++ + F + ++ + N M + T D +L +
Sbjct: 1490 KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETD-DQSPEKINILAKINLL 1548
Query: 90 FVSICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQF---TYLYIAD 146
FV+I T E +K+ Y+ N +N+ D +++I+ + L ++ K F T +
Sbjct: 1549 FVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIR 1608
Query: 147 GMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG----SP 202
+ RIL+LI ++GIRTL+ A+ ++ + ++ LLLFL+M+I++I G F
Sbjct: 1609 LARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEA 1668
Query: 203 DNGDHDNWGNLAAAFFTLFSLATVDGWTDLQKQL--------------------DNREFA 242
D N+ A + LF + T GW L + D A
Sbjct: 1669 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPA 1728
Query: 243 LSRAFTIIFILLASFIFLNMFVGVMI 268
+ F +I+++ I +NM++ +++
Sbjct: 1729 VGILFFTTYIIISFLIVVNMYIAIIL 1754
Score = 53.5 bits (127), Expect = 3e-07
Identities = 55/242 (22%), Positives = 107/242 (44%), Gaps = 34/242 (14%)
Query: 82 LLEFSEIFFVSICTSELSMK-VYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFT 140
LLE+++ F + E+ +K V Y+ N + LD +I+ V + L +
Sbjct: 1238 LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 1297
Query: 141 YLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLF- 199
+ +++LR L+ + +G+R ++ A+ + ++ +VLL+ + IF+I+G LF
Sbjct: 1298 PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1357
Query: 200 GSPDNGDHDNWGNLAAAFFTLFSLATVDG--------WTDLQKQLDN---REFALSRAFT 248
G + G+L + + + + + WT ++ DN AL + +
Sbjct: 1358 GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVYE 1417
Query: 249 ---------------IIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQEMLMGE 293
+IFI+ SF LN+F+GV+I + +K L Q++ M E
Sbjct: 1418 EQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK------LGGQDIFMTE 1471
Query: 294 KQ 295
+Q
Sbjct: 1472 EQ 1473
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.328 0.141 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,678,645
Number of Sequences: 37866
Number of extensions: 489844
Number of successful extensions: 3109
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 86
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 2453
Number of HSP's gapped (non-prelim): 433
length of query: 398
length of database: 18,247,518
effective HSP length: 104
effective length of query: 294
effective length of database: 14,309,454
effective search space: 4206979476
effective search space used: 4206979476
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.