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Search of human proteins with 122937351
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122937351 hypothetical protein LOC389257 [Homo sapiens]
(514 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122937351 hypothetical protein LOC389257 [Homo sapiens] 1017 0.0
gi|7661860 leucine rich repeat containing 14 [Homo sapiens] 206 5e-53
gi|46249373 preferentially expressed antigen in melanoma [Homo s... 119 5e-27
gi|46249371 preferentially expressed antigen in melanoma [Homo s... 119 5e-27
gi|46249369 preferentially expressed antigen in melanoma [Homo s... 119 5e-27
gi|46249367 preferentially expressed antigen in melanoma [Homo s... 119 5e-27
gi|5174641 preferentially expressed antigen in melanoma [Homo sa... 119 5e-27
gi|169216010 PREDICTED: preferentially expressed antigen in mela... 114 3e-25
gi|169215813 PREDICTED: preferentially expressed antigen in mela... 114 3e-25
gi|239746677 PREDICTED: preferentially expressed antigen in mela... 112 6e-25
gi|58219004 PRAME family member 6 [Homo sapiens] 106 4e-23
gi|239741047 PREDICTED: PRAME family member 25-like [Homo sapiens] 105 1e-22
gi|61696142 PRAME family member 5 [Homo sapiens] 104 2e-22
gi|239741045 PREDICTED: PRAME family member 23 [Homo sapiens] 104 2e-22
gi|59676593 PRAME family member 7 [Homo sapiens] 103 4e-22
gi|239741053 PREDICTED: similar to Putative PRAME family member ... 103 4e-22
gi|59676587 PRAME family member 8 [Homo sapiens] 103 4e-22
gi|124249372 PRAME family member 12 [Homo sapiens] 102 8e-22
gi|148356236 PRAME family member 15 [Homo sapiens] 100 2e-21
gi|61102721 PRAME family member 9 [Homo sapiens] 100 2e-21
gi|153792112 PRAME family member 20 [Homo sapiens] 100 4e-21
gi|153945800 PRAME family member 21 [Homo sapiens] 100 4e-21
gi|88942379 PREDICTED: PRAME family member [Homo sapiens] 97 5e-20
gi|239741043 PREDICTED: PRAME family member 11 [Homo sapiens] 97 5e-20
gi|59958373 PRAME family member 4 [Homo sapiens] 97 5e-20
gi|226437621 PRAME family member 11 [Homo sapiens] 92 9e-19
gi|194018546 PRAME family member 10 [Homo sapiens] 72 9e-13
gi|157426839 PRAME family member 17 [Homo sapiens] 70 6e-12
gi|113865933 PRAME family member 16 [Homo sapiens] 70 6e-12
gi|194306638 PRAME family member 3 [Homo sapiens] 68 2e-11
>gi|122937351 hypothetical protein LOC389257 [Homo sapiens]
Length = 514
Score = 1017 bits (2629), Expect = 0.0
Identities = 514/514 (100%), Positives = 514/514 (100%)
Query: 1 MDTMRSLRFISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLE 60
MDTMRSLRFISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLE
Sbjct: 1 MDTMRSLRFISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLE 60
Query: 61 EFRLGALLGPGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRRLRVADLTGIRDVQV 120
EFRLGALLGPGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRRLRVADLTGIRDVQV
Sbjct: 61 EFRLGALLGPGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRRLRVADLTGIRDVQV 120
Query: 121 QRCPCGRALGRWGRTQLLARTCCELQAEPLAAGRPVEVLADLFVTEGNFEAVVQALRPAG 180
QRCPCGRALGRWGRTQLLARTCCELQAEPLAAGRPVEVLADLFVTEGNFEAVVQALRPAG
Sbjct: 121 QRCPCGRALGRWGRTQLLARTCCELQAEPLAAGRPVEVLADLFVTEGNFEAVVQALRPAG 180
Query: 181 PAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQLLAQVGFPR 240
PAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQLLAQVGFPR
Sbjct: 181 PAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQLLAQVGFPR 240
Query: 241 LASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSVAFSTLTGKIPTLLG 300
LASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSVAFSTLTGKIPTLLG
Sbjct: 241 LASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSVAFSTLTGKIPTLLG 300
Query: 301 PLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFRLLSQASR 360
PLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFRLLSQASR
Sbjct: 301 PLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFRLLSQASR 360
Query: 361 TLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALCELPELRC 420
TLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALCELPELRC
Sbjct: 361 TLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALCELPELRC 420
Query: 421 IEFPVPKDCYPEGAAYPQDELAMSKFNQQKYDEIAEELRAVLLRADREDIQVSTPLFGSF 480
IEFPVPKDCYPEGAAYPQDELAMSKFNQQKYDEIAEELRAVLLRADREDIQVSTPLFGSF
Sbjct: 421 IEFPVPKDCYPEGAAYPQDELAMSKFNQQKYDEIAEELRAVLLRADREDIQVSTPLFGSF 480
Query: 481 DPDIQETSNELGAFLLQAFKTALENFSRALKQIE 514
DPDIQETSNELGAFLLQAFKTALENFSRALKQIE
Sbjct: 481 DPDIQETSNELGAFLLQAFKTALENFSRALKQIE 514
>gi|7661860 leucine rich repeat containing 14 [Homo sapiens]
Length = 493
Score = 206 bits (523), Expect = 5e-53
Identities = 160/497 (32%), Positives = 245/497 (49%), Gaps = 25/497 (5%)
Query: 4 MRSLRFISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFR 63
M +L F+S ++ A Q+L + L+PLLFK +++ ++ V R ++ WP
Sbjct: 1 MHTLVFLSTRQVLQCQPAACQALPLLPRELFPLLFKVAFMDKKTVVLRELVHTWPFPLLS 60
Query: 64 LGALLGPGADHPQDL-RDRTCRACLEALVRGLADHVLQDRS---------RRRLRVADLT 113
LL A + L ++R ++A++ GL + + LRV D+T
Sbjct: 61 FQQLLQECAHCSRALLQERPSTESMQAVILGLTARLHTSEPGASTQPLCRKHALRVLDMT 120
Query: 114 GIRDVQVQRCPCGRALGRWGRTQLLARTCCELQ----AEPLAAGRPVEVLADLFVTEGNF 169
G+ D V++ P + W T +ARTC Q AEP A PVEV DL V ++
Sbjct: 121 GLLDDGVEQDP--GTMSMWDCTAAVARTCIAQQQGGAAEPGPAPIPVEVRVDLRVNRASY 178
Query: 170 EAVVQALRPAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHV 229
+ +ALR + +PLR+ C RA+ L + +L+L G LR++++ N L +
Sbjct: 179 AFLREALRSSVGSPLRLCCRDLRAEDLPMRNTVALLQLLDAGCLRRVDLRFN-NLGLRGL 237
Query: 230 QQLLAQVG-FPRLASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSVAF 288
++ V F LASL L D+ + DGED +A ++ + L ELS+
Sbjct: 238 SVIIPHVARFQHLASLRLHYVHGDSRQP---SVDGEDNFRYFLA-QMGRFTCLRELSMGS 293
Query: 289 STLTGKIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYP 348
S L+G++ LL LQ+PL L+LA CAL D+ FLA HAAHL+ LDLSG++L
Sbjct: 294 SLLSGRLDQLLSTLQSPLESLELAFCALLPEDLRFLARSPHAAHLKKLDLSGNDLSGSQL 353
Query: 349 STFFRLLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRL 408
+ F LL ++ TL L L EC + D+ + + L+ C LR L GNPLS L+ L
Sbjct: 354 APFQGLLQASAATLLHLELTECQLADTQLLATLPILTQCASLRYLGLYGNPLSMAGLKEL 413
Query: 409 FTALCELPELRCIEFPVPKDCYPEGAAY--PQDELAMSKFNQQKYDEIAEELRAVLLRAD 466
ELR + P P DCY EG + P L + N++K+ + EL +LL +
Sbjct: 414 LRDSVAQAELRTVVHPFPVDCY-EGLPWPPPASVLLEASINEEKFARVEAELHQLLLASG 472
Query: 467 REDIQVSTPLFGSFDPD 483
R + +T ++G D
Sbjct: 473 RAHVLWTTDIYGRLAAD 489
>gi|46249373 preferentially expressed antigen in melanoma [Homo
sapiens]
Length = 509
Score = 119 bits (299), Expect = 5e-27
Identities = 118/443 (26%), Positives = 191/443 (43%), Gaps = 31/443 (6%)
Query: 5 RSLRFISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRL 64
R L ++ ++L+ +A +L+ + L+P LF A++ ++ +A++ WP L
Sbjct: 24 RRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCLPL 83
Query: 65 GALLGPGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRR-RLRVADLTGIRDVQVQRC 123
G L+ Q L T +A L+ L LA V R RR +L+V DL
Sbjct: 84 GVLM-----KGQHLHLETFKAVLDGLDVLLAQEV---RPRRWKLQVLDLRKNSHQDFWTV 135
Query: 124 PCGRALGRWGRTQLLA-------RTCCELQAEPLAAGRPVEVLADLFVTEGN----FEAV 172
G + + A R L E PVEVL DLF+ EG F +
Sbjct: 136 WSGNRASLYSFPEPEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYL 195
Query: 173 VQALRPAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLH--AGHVQ 230
++ ++ LR+ C + ++ + +L++ ++ LEV +L A
Sbjct: 196 IEKVKRKKNV-LRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSP 254
Query: 231 QLLAQVGFPRLASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFS 289
L + RL + ++ +P+ E+ +A + + L L V +
Sbjct: 255 YLGQMINLRRLLLSHIHASSY-------ISPEKEEQYIAQFTSQFLSLQCLQALYVDSLF 307
Query: 290 TLTGKIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPS 349
L G++ LL + PL L + NC L+ D+ L+ + L VL LSG L + P
Sbjct: 308 FLRGRLDQLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPE 367
Query: 350 TFFRLLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLF 409
LL +AS TL+ L +ECGI D + L+ LS C +L L F GN +S AL+ L
Sbjct: 368 PLQALLERASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLL 427
Query: 410 TALCELPELRCIEFPVPKDCYPE 432
L L L + +PVP + Y +
Sbjct: 428 QHLIGLSNLTHVLYPVPLESYED 450
>gi|46249371 preferentially expressed antigen in melanoma [Homo
sapiens]
Length = 509
Score = 119 bits (299), Expect = 5e-27
Identities = 118/443 (26%), Positives = 191/443 (43%), Gaps = 31/443 (6%)
Query: 5 RSLRFISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRL 64
R L ++ ++L+ +A +L+ + L+P LF A++ ++ +A++ WP L
Sbjct: 24 RRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCLPL 83
Query: 65 GALLGPGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRR-RLRVADLTGIRDVQVQRC 123
G L+ Q L T +A L+ L LA V R RR +L+V DL
Sbjct: 84 GVLM-----KGQHLHLETFKAVLDGLDVLLAQEV---RPRRWKLQVLDLRKNSHQDFWTV 135
Query: 124 PCGRALGRWGRTQLLA-------RTCCELQAEPLAAGRPVEVLADLFVTEGN----FEAV 172
G + + A R L E PVEVL DLF+ EG F +
Sbjct: 136 WSGNRASLYSFPEPEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYL 195
Query: 173 VQALRPAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLH--AGHVQ 230
++ ++ LR+ C + ++ + +L++ ++ LEV +L A
Sbjct: 196 IEKVKRKKNV-LRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSP 254
Query: 231 QLLAQVGFPRLASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFS 289
L + RL + ++ +P+ E+ +A + + L L V +
Sbjct: 255 YLGQMINLRRLLLSHIHASSY-------ISPEKEEQYIAQFTSQFLSLQCLQALYVDSLF 307
Query: 290 TLTGKIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPS 349
L G++ LL + PL L + NC L+ D+ L+ + L VL LSG L + P
Sbjct: 308 FLRGRLDQLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPE 367
Query: 350 TFFRLLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLF 409
LL +AS TL+ L +ECGI D + L+ LS C +L L F GN +S AL+ L
Sbjct: 368 PLQALLERASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLL 427
Query: 410 TALCELPELRCIEFPVPKDCYPE 432
L L L + +PVP + Y +
Sbjct: 428 QHLIGLSNLTHVLYPVPLESYED 450
>gi|46249369 preferentially expressed antigen in melanoma [Homo
sapiens]
Length = 509
Score = 119 bits (299), Expect = 5e-27
Identities = 118/443 (26%), Positives = 191/443 (43%), Gaps = 31/443 (6%)
Query: 5 RSLRFISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRL 64
R L ++ ++L+ +A +L+ + L+P LF A++ ++ +A++ WP L
Sbjct: 24 RRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCLPL 83
Query: 65 GALLGPGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRR-RLRVADLTGIRDVQVQRC 123
G L+ Q L T +A L+ L LA V R RR +L+V DL
Sbjct: 84 GVLM-----KGQHLHLETFKAVLDGLDVLLAQEV---RPRRWKLQVLDLRKNSHQDFWTV 135
Query: 124 PCGRALGRWGRTQLLA-------RTCCELQAEPLAAGRPVEVLADLFVTEGN----FEAV 172
G + + A R L E PVEVL DLF+ EG F +
Sbjct: 136 WSGNRASLYSFPEPEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYL 195
Query: 173 VQALRPAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLH--AGHVQ 230
++ ++ LR+ C + ++ + +L++ ++ LEV +L A
Sbjct: 196 IEKVKRKKNV-LRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSP 254
Query: 231 QLLAQVGFPRLASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFS 289
L + RL + ++ +P+ E+ +A + + L L V +
Sbjct: 255 YLGQMINLRRLLLSHIHASSY-------ISPEKEEQYIAQFTSQFLSLQCLQALYVDSLF 307
Query: 290 TLTGKIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPS 349
L G++ LL + PL L + NC L+ D+ L+ + L VL LSG L + P
Sbjct: 308 FLRGRLDQLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPE 367
Query: 350 TFFRLLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLF 409
LL +AS TL+ L +ECGI D + L+ LS C +L L F GN +S AL+ L
Sbjct: 368 PLQALLERASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLL 427
Query: 410 TALCELPELRCIEFPVPKDCYPE 432
L L L + +PVP + Y +
Sbjct: 428 QHLIGLSNLTHVLYPVPLESYED 450
>gi|46249367 preferentially expressed antigen in melanoma [Homo
sapiens]
Length = 509
Score = 119 bits (299), Expect = 5e-27
Identities = 118/443 (26%), Positives = 191/443 (43%), Gaps = 31/443 (6%)
Query: 5 RSLRFISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRL 64
R L ++ ++L+ +A +L+ + L+P LF A++ ++ +A++ WP L
Sbjct: 24 RRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCLPL 83
Query: 65 GALLGPGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRR-RLRVADLTGIRDVQVQRC 123
G L+ Q L T +A L+ L LA V R RR +L+V DL
Sbjct: 84 GVLM-----KGQHLHLETFKAVLDGLDVLLAQEV---RPRRWKLQVLDLRKNSHQDFWTV 135
Query: 124 PCGRALGRWGRTQLLA-------RTCCELQAEPLAAGRPVEVLADLFVTEGN----FEAV 172
G + + A R L E PVEVL DLF+ EG F +
Sbjct: 136 WSGNRASLYSFPEPEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYL 195
Query: 173 VQALRPAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLH--AGHVQ 230
++ ++ LR+ C + ++ + +L++ ++ LEV +L A
Sbjct: 196 IEKVKRKKNV-LRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSP 254
Query: 231 QLLAQVGFPRLASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFS 289
L + RL + ++ +P+ E+ +A + + L L V +
Sbjct: 255 YLGQMINLRRLLLSHIHASSY-------ISPEKEEQYIAQFTSQFLSLQCLQALYVDSLF 307
Query: 290 TLTGKIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPS 349
L G++ LL + PL L + NC L+ D+ L+ + L VL LSG L + P
Sbjct: 308 FLRGRLDQLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPE 367
Query: 350 TFFRLLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLF 409
LL +AS TL+ L +ECGI D + L+ LS C +L L F GN +S AL+ L
Sbjct: 368 PLQALLERASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLL 427
Query: 410 TALCELPELRCIEFPVPKDCYPE 432
L L L + +PVP + Y +
Sbjct: 428 QHLIGLSNLTHVLYPVPLESYED 450
>gi|5174641 preferentially expressed antigen in melanoma [Homo
sapiens]
Length = 509
Score = 119 bits (299), Expect = 5e-27
Identities = 118/443 (26%), Positives = 191/443 (43%), Gaps = 31/443 (6%)
Query: 5 RSLRFISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRL 64
R L ++ ++L+ +A +L+ + L+P LF A++ ++ +A++ WP L
Sbjct: 24 RRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCLPL 83
Query: 65 GALLGPGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRR-RLRVADLTGIRDVQVQRC 123
G L+ Q L T +A L+ L LA V R RR +L+V DL
Sbjct: 84 GVLM-----KGQHLHLETFKAVLDGLDVLLAQEV---RPRRWKLQVLDLRKNSHQDFWTV 135
Query: 124 PCGRALGRWGRTQLLA-------RTCCELQAEPLAAGRPVEVLADLFVTEGN----FEAV 172
G + + A R L E PVEVL DLF+ EG F +
Sbjct: 136 WSGNRASLYSFPEPEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYL 195
Query: 173 VQALRPAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLH--AGHVQ 230
++ ++ LR+ C + ++ + +L++ ++ LEV +L A
Sbjct: 196 IEKVKRKKNV-LRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSP 254
Query: 231 QLLAQVGFPRLASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFS 289
L + RL + ++ +P+ E+ +A + + L L V +
Sbjct: 255 YLGQMINLRRLLLSHIHASSY-------ISPEKEEQYIAQFTSQFLSLQCLQALYVDSLF 307
Query: 290 TLTGKIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPS 349
L G++ LL + PL L + NC L+ D+ L+ + L VL LSG L + P
Sbjct: 308 FLRGRLDQLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPE 367
Query: 350 TFFRLLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLF 409
LL +AS TL+ L +ECGI D + L+ LS C +L L F GN +S AL+ L
Sbjct: 368 PLQALLERASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLL 427
Query: 410 TALCELPELRCIEFPVPKDCYPE 432
L L L + +PVP + Y +
Sbjct: 428 QHLIGLSNLTHVLYPVPLESYED 450
>gi|169216010 PREDICTED: preferentially expressed antigen in
melanoma-like [Homo sapiens]
Length = 520
Score = 114 bits (284), Expect = 3e-25
Identities = 123/479 (25%), Positives = 209/479 (43%), Gaps = 50/479 (10%)
Query: 6 SLRFISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLG 65
SL ++A +L+S+ L+ + NL+P L A++ + +A++ WP LG
Sbjct: 69 SLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFLHLG 128
Query: 66 ALL--GPGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRR--LRVADLTGIRDVQVQ 121
+L+ P D L+A+V GL R+ LR+ D T + QV
Sbjct: 129 SLIVQWPNQDS------------LQAVVDGLEAFSAHRACPRKSELRMLDFT-LDSEQVF 175
Query: 122 RCPCG--RALGR---WGRTQLLARTCCELQAEPLAAGRPVEVLADLFVTEGNFEAVVQAL 176
C G AL + W + + A T P A RP + D F+++ ++ +
Sbjct: 176 YCGKGASEALAKFPFWLPSAVKAET-------PQATARPKPL--DKFLSD-----LLTKV 221
Query: 177 RPAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQLLAQV 236
+ A L + C + ++ LL +L+ +++LEV + R + L+ +
Sbjct: 222 EQSHGA-LHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAI 280
Query: 237 GFPRLASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSVAFSTLTGKIP 296
R+ +L K F ++S S +L+ + L +L ++ S L GK+
Sbjct: 281 QLGRIFNLR-SLKLFYYKWAFSSWVRRPSSYFFS---QLTMLGHLRKLHLSHSYLVGKLH 336
Query: 297 TLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFRLLS 356
+L L PL L++ NC L TD+ +L+ H L+ LDLS ++L + P LL
Sbjct: 337 YILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLR 396
Query: 357 QASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALCELP 416
S TL+ L L+ C + D+H+ L+ L C L L NP+S+ L L L
Sbjct: 397 AVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLM 456
Query: 417 ELRCIEFPVPKDC--YPEGAAYPQDELAMSKFNQQKYDEIAEELRAVLLRADREDIQVS 473
EL+ + +P+P DC Y G + N+ K ++ E++ L + D+Q S
Sbjct: 457 ELKQVLYPIPVDCCIYLHG-------VCRGPVNEDKLCQLQAEIQKQLQAMQQADMQWS 508
>gi|169215813 PREDICTED: preferentially expressed antigen in
melanoma-like [Homo sapiens]
Length = 520
Score = 114 bits (284), Expect = 3e-25
Identities = 123/479 (25%), Positives = 209/479 (43%), Gaps = 50/479 (10%)
Query: 6 SLRFISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLG 65
SL ++A +L+S+ L+ + NL+P L A++ + +A++ WP LG
Sbjct: 69 SLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFLHLG 128
Query: 66 ALL--GPGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRR--LRVADLTGIRDVQVQ 121
+L+ P D L+A+V GL R+ LR+ D T + QV
Sbjct: 129 SLIVQWPNQDS------------LQAVVDGLEAFSAHRACPRKSELRMLDFT-LDSEQVF 175
Query: 122 RCPCG--RALGR---WGRTQLLARTCCELQAEPLAAGRPVEVLADLFVTEGNFEAVVQAL 176
C G AL + W + + A T P A RP + D F+++ ++ +
Sbjct: 176 YCGKGASEALAKFPFWLPSAVKAET-------PQATARPKPL--DKFLSD-----LLTKV 221
Query: 177 RPAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQLLAQV 236
+ A L + C + ++ LL +L+ +++LEV + R + L+ +
Sbjct: 222 EQSHGA-LHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAI 280
Query: 237 GFPRLASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSVAFSTLTGKIP 296
R+ +L K F ++S S +L+ + L +L ++ S L GK+
Sbjct: 281 QLGRIFNLR-SLKLFYYKWAFSSWVRRPSSYFFS---QLTMLGHLRKLHLSHSYLVGKLH 336
Query: 297 TLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFRLLS 356
+L L PL L++ NC L TD+ +L+ H L+ LDLS ++L + P LL
Sbjct: 337 YILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLR 396
Query: 357 QASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALCELP 416
S TL+ L L+ C + D+H+ L+ L C L L NP+S+ L L L
Sbjct: 397 AVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLM 456
Query: 417 ELRCIEFPVPKDC--YPEGAAYPQDELAMSKFNQQKYDEIAEELRAVLLRADREDIQVS 473
EL+ + +P+P DC Y G + N+ K ++ E++ L + D+Q S
Sbjct: 457 ELKQVLYPIPVDCCIYLHG-------VCRGPVNEDKLCQLQAEIQKQLQAMQQADMQWS 508
>gi|239746677 PREDICTED: preferentially expressed antigen in
melanoma-like [Homo sapiens]
Length = 520
Score = 112 bits (281), Expect = 6e-25
Identities = 123/479 (25%), Positives = 209/479 (43%), Gaps = 50/479 (10%)
Query: 6 SLRFISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLG 65
SL ++A +L+S+ L+ + NL+P L A++ + +A++ WP LG
Sbjct: 69 SLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFLHLG 128
Query: 66 ALL--GPGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRR--LRVADLTGIRDVQVQ 121
+L+ P D L+A+V GL R+ LR+ D T + QV
Sbjct: 129 SLIVQWPNQDS------------LQAVVDGLEAFSAHRACPRKSELRMLDFT-LDSEQVF 175
Query: 122 RCPCG--RALGR---WGRTQLLARTCCELQAEPLAAGRPVEVLADLFVTEGNFEAVVQAL 176
C G AL + W + + A T P A RP + D F+++ ++ +
Sbjct: 176 YCGKGASEALTKFPFWLPSAVKAET-------PQATARPKPL--DKFLSD-----LLTKV 221
Query: 177 RPAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQLLAQV 236
+ A L + C + ++ LL +L+ +++LEV + R + L+ +
Sbjct: 222 EQSHGA-LHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAI 280
Query: 237 GFPRLASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSVAFSTLTGKIP 296
R+ +L K F ++S S +L+ + L +L ++ S L GK+
Sbjct: 281 QLGRIFNLR-SFKLFYYKWAFSSWVRRPSSYFFS---QLTMLGHLRKLHLSHSYLVGKLH 336
Query: 297 TLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFRLLS 356
+L L PL L++ NC L TD+ +L+ H L+ LDLS ++L + P LL
Sbjct: 337 YILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLR 396
Query: 357 QASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALCELP 416
S TL+ L L+ C + D+H+ L+ L C L L NP+S+ L L L
Sbjct: 397 AVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLM 456
Query: 417 ELRCIEFPVPKDC--YPEGAAYPQDELAMSKFNQQKYDEIAEELRAVLLRADREDIQVS 473
EL+ + +P+P DC Y G + N+ K ++ E++ L + D+Q S
Sbjct: 457 ELKQVLYPIPVDCCIYLHG-------VCRGPVNEDKLCQLQAEIQKQLQAMQQADMQWS 508
>gi|58219004 PRAME family member 6 [Homo sapiens]
Length = 476
Score = 106 bits (265), Expect = 4e-23
Identities = 107/438 (24%), Positives = 186/438 (42%), Gaps = 46/438 (10%)
Query: 10 ISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLG 69
++ +L+ +A +L+ + L+P LF ++ + E + ++ WP L L+
Sbjct: 12 LAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLPLRPLI- 70
Query: 70 PGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRR--LRVADLTGIRDVQVQRCPCGR 127
C +A++ GL + Q RR L+V DL + C
Sbjct: 71 ----------KMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDV---------CEN 111
Query: 128 ALGRWGRTQLLARTC--------CELQAEPLAAGR-PVEVLADLFVTEGNFEAVVQALR- 177
W ++ +AR C +Q P G+ P+ V +L++ + + L
Sbjct: 112 FWMVW--SEAMARGCFLNAKRNKTPVQDCPRMRGQQPLTVFVELWLKNRTLDEYLTCLLL 169
Query: 178 --PAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQLLAQ 235
L + C + + + +L++ ++++EV N + + Q
Sbjct: 170 WVKQRKDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEV--NCKWVLPILTQFTPY 227
Query: 236 VGFPR-LASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFSTLTG 293
+G R L L L Y S P+ + ++ + K+ L +LS+ + S L G
Sbjct: 228 LGHMRNLQKLVLSHMDVSR---YVS-PEQKKEIVTQFTTQFLKLCCLQKLSMNSVSFLEG 283
Query: 294 KIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFR 353
+ LL L+T L+VL + NC L +D+ L+ C + L+ LDLSG L +
Sbjct: 284 HLDQLLSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQI 343
Query: 354 LLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALC 413
LL + + TL L L++CGI+DS V ++ LS C L F GNP+S L L +
Sbjct: 344 LLEKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPISMATLENLLSHTI 403
Query: 414 ELPELRCIE-FPVPKDCY 430
L L C+E +P P++ Y
Sbjct: 404 ILKNL-CVELYPAPRESY 420
>gi|239741047 PREDICTED: PRAME family member 25-like [Homo sapiens]
Length = 474
Score = 105 bits (262), Expect = 1e-22
Identities = 129/495 (26%), Positives = 213/495 (43%), Gaps = 59/495 (11%)
Query: 5 RSLRFISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRL 64
R L ++ ++L+ +A LD + L+P LF ++ + EV + ++ WP L
Sbjct: 7 RRLLELAGQSLLGDQALAISILDELPRELFPPLFVEAFTSRRCEVLKVMVQAWPFPCLPL 66
Query: 65 GALLGPGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRRLRVADLTGIRDVQ----- 119
G+L+ DL L +V G+ D +L + R R R + +RDV
Sbjct: 67 GSLM-----KTPDLE------ILHYVVDGI-DCLLAQKVRPRRRKLQVLELRDVDENFWT 114
Query: 120 ----VQRCPCG-RALGRWGRTQLLARTCCELQAEPLAAGRPVEVLADLFVTE--GNFEAV 172
+ C A+ + + RT + +PL V L + F+ E F
Sbjct: 115 IWSGARPLSCSPEAMSKRQTVEDCPRTG---EKQPLKVFMDV-CLKEKFMDEDLSFFSGW 170
Query: 173 VQALRPAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQL 232
VQ R + + + C S+S ++L P +++ LE+ +
Sbjct: 171 VQHRRGS----VHLCCTKVVNYSMSILNFRNILETVYPDSIQVLEIWNMC-------WPC 219
Query: 233 LAQVGFPRLASLTLPTKAFDAPPT-YASTPDGEDPLLASIARELSKMAQLTELSV-AFST 290
+ P L+ + K F + Y + D ++ + A + K+ L +L + + S
Sbjct: 220 MIVEFSPYLSQMRNLRKLFISDGCRYLLSSDSQEQI-APFTTQFLKLHCLQKLYMNSVSF 278
Query: 291 LTGKIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPST 350
L G + LL L+T L+VL + NC L +D+ L+ C + L+ LDLSG L +
Sbjct: 279 LEGHLDQLLSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVP 338
Query: 351 FFRLLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFT 410
LL + + TL L L++CGI+DS V ++ LS C L F GNP+S L L +
Sbjct: 339 LQILLEKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPISMATLENLLS 398
Query: 411 ALCELPELRCIE-FPVPKDCYPEGAAYPQDELAMSKFNQQKYDEIAEELRAVLLRADRED 469
L L C+E +P P++ Y GA L S+F Q +RA L++ R+
Sbjct: 399 HTIILKNL-CLELYPAPRESY--GA---DGTLCWSRFTQ---------IRAELMKRVRDL 443
Query: 470 IQVSTPLFGS-FDPD 483
LFG+ + PD
Sbjct: 444 RHPKRILFGTDYCPD 458
>gi|61696142 PRAME family member 5 [Homo sapiens]
Length = 476
Score = 104 bits (260), Expect = 2e-22
Identities = 104/433 (24%), Positives = 186/433 (42%), Gaps = 36/433 (8%)
Query: 10 ISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLG 69
++ +L+ +A +L+ + L+P LF ++ + E + ++ WP L L+
Sbjct: 12 LAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLPLRPLI- 70
Query: 70 PGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRR--LRVADLTGIRD----VQVQRC 123
C +A++ GL + Q RR L+V DL + + V +
Sbjct: 71 ----------KMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDVCENFWMVWSEAM 120
Query: 124 PCGRALGRWGRTQLLARTCCELQAEPLAAGRPVEVLADLFVTEGNFEAVVQALR---PAG 180
G L R + + C ++ + +P+ V +L++ + + L
Sbjct: 121 AHGCFLNA-KRNKKPVQDCPRMRGQ-----QPLTVFVELWLKNRTLDEYLTCLLLWVKQR 174
Query: 181 PAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQLLAQVGFPR 240
L + C + + + +L++ ++++EV N + + Q +G R
Sbjct: 175 KDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEV--NCKWVLPILTQFTPYLGHMR 232
Query: 241 -LASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFSTLTGKIPTL 298
L L L Y S P+ + ++ + K+ L +LS+ + S L G + L
Sbjct: 233 NLQKLVLSHMDVSR---YVS-PEQKKEIVTQFTTQFLKLCCLQKLSMNSVSFLEGHLDQL 288
Query: 299 LGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFRLLSQA 358
L L+T L+VL + NC L +D+ L+ C + L+ LDLSG L + LL +
Sbjct: 289 LSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKV 348
Query: 359 SRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALCELPEL 418
+ TL L L++CGI+DS V ++ LS C L F GNP+S L L + L L
Sbjct: 349 AATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPISMATLENLLSHTIILKNL 408
Query: 419 RCIE-FPVPKDCY 430
C+E +P P++ Y
Sbjct: 409 -CVELYPAPRESY 420
>gi|239741045 PREDICTED: PRAME family member 23 [Homo sapiens]
Length = 476
Score = 104 bits (259), Expect = 2e-22
Identities = 104/433 (24%), Positives = 186/433 (42%), Gaps = 36/433 (8%)
Query: 10 ISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLG 69
++ +L+ +A +L+ + L+P LF ++ + E + ++ WP L L+
Sbjct: 12 LAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLPLRPLI- 70
Query: 70 PGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRR--LRVADLTGIRD----VQVQRC 123
C +A++ GL + Q RR L+V DL + + V +
Sbjct: 71 ----------KMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDVCENFWMVWSEAM 120
Query: 124 PCGRALGRWGRTQLLARTCCELQAEPLAAGRPVEVLADLFVTEGNFEAVVQALR---PAG 180
G L R + + C ++ + +P+ V +L++ + + L
Sbjct: 121 AHGCFLNA-KRNKKPVQDCPRMRGQ-----QPLTVFVELWLKNRTLDEYLTCLLLWVKQR 174
Query: 181 PAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQLLAQVGFPR 240
L + C + + + +L++ ++++EV N + + Q +G R
Sbjct: 175 KDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEV--NCKWVLPILTQFTPYLGHMR 232
Query: 241 -LASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFSTLTGKIPTL 298
L L L Y S P+ + ++ + K+ L +LS+ + S L G + L
Sbjct: 233 NLQKLVLSHMDVSR---YVS-PEQKKEIVTQFTTQFLKLCCLQKLSMNSVSFLEGHLDQL 288
Query: 299 LGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFRLLSQA 358
L L+T L+VL + NC L +D+ L+ C + L+ LDLSG L + LL +
Sbjct: 289 LSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKV 348
Query: 359 SRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALCELPEL 418
+ TL L L++CGI+DS V ++ LS C L F GNP+S L L + L L
Sbjct: 349 AATLEYLDLDDCGIIDSQVNAILPALSCCFELNTFSFCGNPISMATLENLLSHTIILKNL 408
Query: 419 RCIE-FPVPKDCY 430
C+E +P P++ Y
Sbjct: 409 -CVELYPAPRESY 420
>gi|59676593 PRAME family member 7 [Homo sapiens]
Length = 474
Score = 103 bits (257), Expect = 4e-22
Identities = 102/437 (23%), Positives = 176/437 (40%), Gaps = 46/437 (10%)
Query: 10 ISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLG 69
++ + L+ +A +++ + L+P LF ++ + E + ++ WP LG+L+
Sbjct: 12 LARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRLPLGSLMK 71
Query: 70 PGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRRLRVADLTGIRDVQVQRCPCGRAL 129
+ H + L+ +++ G+ D +L R R + +R+V C
Sbjct: 72 --SPHLESLK---------SVLEGV-DVLLTQEVRPRQSKLQVLDLRNVDENFCDIFS-- 117
Query: 130 GRWGRTQLLARTCCELQAEPLAAG----RPVEVLADLFVTEGNFEAVVQALRPAGPAP-- 183
G T + Q G +P V DL + + + L G
Sbjct: 118 ---GATASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKG 174
Query: 184 -LRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRL--------HAGHVQQLLA 234
L V C + + ++ VL + ++++EV L + G ++ L
Sbjct: 175 LLHVCCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRK 234
Query: 235 QVGFPRLASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFSTLTG 293
V F AS +P PD + +A + K+ LS+ + S L G
Sbjct: 235 LVLFNIRASACIP-------------PDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEG 281
Query: 294 KIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFR 353
+ LL LQ L ++ + +C L+ +D+ L+ C L+ LDL G L P
Sbjct: 282 HLDQLLRCLQASLEMVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTG 341
Query: 354 LLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALC 413
LL Q TL+ L LE+CGI+DS + ++ LS C +L F GN +S AL L
Sbjct: 342 LLEQVVATLQTLDLEDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTV 401
Query: 414 ELPELRCIEFPVPKDCY 430
L +L +P P + Y
Sbjct: 402 GLSKLSLELYPAPLESY 418
>gi|239741053 PREDICTED: similar to Putative PRAME family member 24
[Homo sapiens]
Length = 474
Score = 103 bits (257), Expect = 4e-22
Identities = 102/437 (23%), Positives = 176/437 (40%), Gaps = 46/437 (10%)
Query: 10 ISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLG 69
++ + L+ +A +++ + L+P LF ++ + E + ++ WP LG+L+
Sbjct: 12 LARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRLPLGSLMK 71
Query: 70 PGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRRLRVADLTGIRDVQVQRCPCGRAL 129
+ H + L+ +++ G+ D +L R R + +R+V C
Sbjct: 72 --SPHLESLK---------SVLEGV-DVLLTQEVRPRQSKLQVLDLRNVDENFCDIFS-- 117
Query: 130 GRWGRTQLLARTCCELQAEPLAAG----RPVEVLADLFVTEGNFEAVVQALRPAGPAP-- 183
G T + Q G +P V DL + + + L G
Sbjct: 118 ---GATASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKG 174
Query: 184 -LRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRL--------HAGHVQQLLA 234
L V C + + ++ VL + ++++EV L + G ++ L
Sbjct: 175 LLHVCCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRK 234
Query: 235 QVGFPRLASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFSTLTG 293
V F AS +P PD + +A + K+ LS+ + S L G
Sbjct: 235 LVLFNIRASACIP-------------PDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEG 281
Query: 294 KIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFR 353
+ LL LQ L ++ + +C L+ +D+ L+ C L+ LDL G L P
Sbjct: 282 HLDQLLRCLQASLEMVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTG 341
Query: 354 LLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALC 413
LL Q TL+ L LE+CGI+DS + ++ LS C +L F GN +S AL L
Sbjct: 342 LLEQVVATLQTLDLEDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTV 401
Query: 414 ELPELRCIEFPVPKDCY 430
L +L +P P + Y
Sbjct: 402 GLSKLSLELYPAPLESY 418
>gi|59676587 PRAME family member 8 [Homo sapiens]
Length = 474
Score = 103 bits (257), Expect = 4e-22
Identities = 102/437 (23%), Positives = 176/437 (40%), Gaps = 46/437 (10%)
Query: 10 ISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLG 69
++ + L+ +A +++ + L+P LF ++ + E + ++ WP LG+L+
Sbjct: 12 LARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRLPLGSLMK 71
Query: 70 PGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRRLRVADLTGIRDVQVQRCPCGRAL 129
+ H + L+ +++ G+ D +L R R + +R+V C
Sbjct: 72 --SPHLESLK---------SVLEGV-DVLLTQEVRPRQSKLQVLDLRNVDENFCDIFS-- 117
Query: 130 GRWGRTQLLARTCCELQAEPLAAG----RPVEVLADLFVTEGNFEAVVQALRPAGPAP-- 183
G T + Q G +P V DL + + + L G
Sbjct: 118 ---GATASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKG 174
Query: 184 -LRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRL--------HAGHVQQLLA 234
L V C + + ++ VL + ++++EV L + G ++ L
Sbjct: 175 LLHVCCQELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRK 234
Query: 235 QVGFPRLASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFSTLTG 293
V F AS +P PD + +A + K+ LS+ + S L G
Sbjct: 235 LVLFNIRASACIP-------------PDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEG 281
Query: 294 KIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFR 353
+ LL LQ L ++ + +C L+ +D+ L+ C L+ LDL G L P
Sbjct: 282 HLDQLLRCLQASLEMVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTG 341
Query: 354 LLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALC 413
LL Q TL+ L LE+CGI+DS + ++ LS C +L F GN +S AL L
Sbjct: 342 LLEQVVATLQTLDLEDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTV 401
Query: 414 ELPELRCIEFPVPKDCY 430
L +L +P P + Y
Sbjct: 402 GLSKLSLELYPAPLESY 418
>gi|124249372 PRAME family member 12 [Homo sapiens]
Length = 483
Score = 102 bits (254), Expect = 8e-22
Identities = 112/457 (24%), Positives = 182/457 (39%), Gaps = 55/457 (12%)
Query: 10 ISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLG 69
++ ++L+ +A +L+ + L+P LF ++ E ++ WP LG+L+
Sbjct: 12 LAEQSLLRDRALAIPTLEELPRELFPPLFMEAFTRRCCETLTTMVQAWPFTCLPLGSLM- 70
Query: 70 PGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRR-RLRVADLTGIRDVQVQRCPCGRA 128
+ RA LE L LA V R RR +L+V DL + +
Sbjct: 71 ------KSCNLEIFRAVLEGLDALLAQKV---RPRRWKLQVLDLRNVDE---------NF 112
Query: 129 LGRWGRTQLLARTCCELQAE----PLAAGR-PVEVLADLFVTEGNFEAVVQALRPAGPAP 183
G W L+ + P G+ P+ V+ DL G + + G
Sbjct: 113 WGIWSGASALSPEALSKRRTAGNCPRPGGQQPLMVILDLCFKNGMLDECLTHFLEWGKQR 172
Query: 184 ---LRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRL--------HAGHVQQL 232
L V C + ++ +++ VL ++++EV L + G ++ L
Sbjct: 173 KGLLHVCCKELQIFGIAIHRIIEVLNTVELDCIQEVEVCCPWELSILIRFAPYLGQMRNL 232
Query: 233 LAQVGFPRLASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFSTL 291
V F S +P D ++ + + K+ +L + + S L
Sbjct: 233 RKLVLFNIHVSACIPL-------------DRKEQFVIQFTSQFLKLDYFQKLYMHSVSFL 279
Query: 292 TGKIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTF 351
G + LL LQ PL + + C L+ +D+ L+ C L+ LDL G L P
Sbjct: 280 EGHLDQLLRCLQAPLETVVMTECLLSESDLKHLSWCPSIRQLKELDLRGITLTHFSPEPL 339
Query: 352 FRLLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTA 411
LL QA TL+ L LE+CGIVDS + ++ LS C +L F GN +S AL L
Sbjct: 340 SVLLEQAEATLQTLDLEDCGIVDSQLSAILPALSRCSQLSTFSFCGNLISMAALENLLRH 399
Query: 412 LCELPELRCIEFPVPKDCYPEGAAYPQDELAMSKFNQ 448
L +L +P P + Y Q L +F+Q
Sbjct: 400 TVGLSKLSLELYPAPLESYD-----AQGALCWGRFSQ 431
>gi|148356236 PRAME family member 15 [Homo sapiens]
Length = 478
Score = 100 bits (250), Expect = 2e-21
Identities = 106/438 (24%), Positives = 185/438 (42%), Gaps = 46/438 (10%)
Query: 10 ISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLG 69
++ +L+ +A +L+ + L+P LF ++ + E + ++ WP L L+
Sbjct: 14 LAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLPLRPLI- 72
Query: 70 PGADHPQDLRDRTCRACLEALVRGLADHVLQD-RSRR-RLRVADLTGIRDVQVQRCPCGR 127
C +A++ GL + Q R RR +L+V DL + C
Sbjct: 73 ----------KMPCLEAFQAVLDGLDALLTQGVRPRRWKLQVLDLQDV---------CEN 113
Query: 128 ALGRWGRTQLLARTCC--------ELQAEPLAAGR-PVEVLADLFVTEGNFEAVVQALR- 177
W ++ +A C +Q P GR P+ V +L++ + + L
Sbjct: 114 FWMVW--SEAMAHGCFLNAKRNKKPVQDCPRMRGRQPLTVFVELWLKNRTLDEYLTYLLL 171
Query: 178 --PAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQLLAQ 235
L + C + + + +L++ ++++EV N + + Q
Sbjct: 172 WVKQRKDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEV--NCKWVLPILTQFTPY 229
Query: 236 VGFPR-LASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFSTLTG 293
+G R L L L Y S P+ + ++ + K+ L +L + + S L G
Sbjct: 230 LGHMRNLQKLVLSHMDVSR---YVS-PEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEG 285
Query: 294 KIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFR 353
+ LL L+T L+VL + NC L +D+ L+ C + L+ LDLSG L +
Sbjct: 286 HLDQLLSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQI 345
Query: 354 LLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALC 413
LL + + TL L L++CGI+DS V ++ LS C L F GNP+ L L +
Sbjct: 346 LLEKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTI 405
Query: 414 ELPELRCIE-FPVPKDCY 430
L L C+E +P P++ Y
Sbjct: 406 ILKNL-CVELYPAPRESY 422
>gi|61102721 PRAME family member 9 [Homo sapiens]
Length = 478
Score = 100 bits (250), Expect = 2e-21
Identities = 106/438 (24%), Positives = 185/438 (42%), Gaps = 46/438 (10%)
Query: 10 ISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLG 69
++ +L+ +A +L+ + L+P LF ++ + E + ++ WP L L+
Sbjct: 14 LAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLPLRPLI- 72
Query: 70 PGADHPQDLRDRTCRACLEALVRGLADHVLQD-RSRR-RLRVADLTGIRDVQVQRCPCGR 127
C +A++ GL + Q R RR +L+V DL + C
Sbjct: 73 ----------KMPCLEAFQAVLDGLDALLTQGVRPRRWKLQVLDLQDV---------CEN 113
Query: 128 ALGRWGRTQLLARTCC--------ELQAEPLAAGR-PVEVLADLFVTEGNFEAVVQALR- 177
W ++ +A C +Q P GR P+ V +L++ + + L
Sbjct: 114 FWMVW--SEAMAHGCFLNAKRNKKPVQDCPRMRGRQPLTVFVELWLKNRTLDEYLTYLLL 171
Query: 178 --PAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQLLAQ 235
L + C + + + +L++ ++++EV N + + Q
Sbjct: 172 WVKQRKDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEV--NCKWVLPILTQFTPY 229
Query: 236 VGFPR-LASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFSTLTG 293
+G R L L L Y S P+ + ++ + K+ L +L + + S L G
Sbjct: 230 LGHMRNLQKLVLSHMDVSR---YVS-PEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEG 285
Query: 294 KIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFR 353
+ LL L+T L+VL + NC L +D+ L+ C + L+ LDLSG L +
Sbjct: 286 HLDQLLSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQI 345
Query: 354 LLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALC 413
LL + + TL L L++CGI+DS V ++ LS C L F GNP+ L L +
Sbjct: 346 LLEKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTI 405
Query: 414 ELPELRCIE-FPVPKDCY 430
L L C+E +P P++ Y
Sbjct: 406 ILKNL-CVELYPAPRESY 422
>gi|153792112 PRAME family member 20 [Homo sapiens]
Length = 475
Score = 100 bits (248), Expect = 4e-21
Identities = 105/438 (23%), Positives = 182/438 (41%), Gaps = 47/438 (10%)
Query: 10 ISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLG 69
++ +L+ +A +L+ + L+P LF ++ E + ++ WP LG+L+
Sbjct: 12 LAGRSLLRDEALAISTLEELPTELFPPLFMEAFSRRHCEALKLMVQAWPFLRLPLGSLM- 70
Query: 70 PGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRR---LRVADLTGIRD--------V 118
R C +A++ GL D +L R R R L+V DL + +
Sbjct: 71 ----------KRPCPETFQAVLDGL-DALLTHRVRLRRWKLQVLDLQDVSENFWMVWSEA 119
Query: 119 QVQRCPCGRALGRWGRTQLLARTCCELQAEPLAAGRPVEVLADLFVTEGNFEAVVQALR- 177
+RC + R + C ++ + +P+ V DL + + L
Sbjct: 120 MARRCLPNAMMNRKP-----VQDCPRMRGQ-----QPLTVFIDLCLKNRTLDEYFTCLFL 169
Query: 178 --PAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQLLAQ 235
+ + C + + + ++L+ ++++EV N L + +
Sbjct: 170 WVKQREGLVHLCCKKLKMLGMLFHNIRNILKTVNLDCIQEVEVNCNWTLPV--LAEFTPY 227
Query: 236 VGFPR-LASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFSTLTG 293
+G R L L L D Y S P+ + + + K+ L +L + + S L G
Sbjct: 228 LGQMRNLRKLVLS----DIDSRYIS-PEQKKEFVTQFTTQFLKLRCLQKLYMNSVSFLEG 282
Query: 294 KIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFR 353
+ +L L+T L +L + NC L +D+ L+ L+ LDLSG L +
Sbjct: 283 HLDQMLSCLKTSLNILAITNCVLLESDLKHLSKYPSIGQLKTLDLSGTRLANFSLVPLQV 342
Query: 354 LLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALC 413
LL + + TL L L++CGIVDS V ++ LS C L F GNP+S L L
Sbjct: 343 LLEKVAATLEYLDLDDCGIVDSQVNAILPALSRCFELTTFSFRGNPISTATLENLLCHTI 402
Query: 414 ELPELRCIE-FPVPKDCY 430
L L C+E +P P++ Y
Sbjct: 403 RLNNL-CLELYPAPRESY 419
>gi|153945800 PRAME family member 21 [Homo sapiens]
Length = 475
Score = 100 bits (248), Expect = 4e-21
Identities = 105/438 (23%), Positives = 182/438 (41%), Gaps = 47/438 (10%)
Query: 10 ISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLG 69
++ +L+ +A +L+ + L+P LF ++ E + ++ WP LG+L+
Sbjct: 12 LAGRSLLRDEALAISTLEELPTELFPPLFMEAFSRRHCEALKLMVQAWPFLRLPLGSLM- 70
Query: 70 PGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRR---LRVADLTGIRD--------V 118
R C +A++ GL D +L R R R L+V DL + +
Sbjct: 71 ----------KRPCPETFQAVLDGL-DALLTHRVRLRRWKLQVLDLQDVSENFWMVWSEA 119
Query: 119 QVQRCPCGRALGRWGRTQLLARTCCELQAEPLAAGRPVEVLADLFVTEGNFEAVVQALR- 177
+RC + R + C ++ + +P+ V DL + + L
Sbjct: 120 MARRCLPNAMMNRKP-----VQDCPRMRGQ-----QPLTVFIDLCLKNRTLDEYFTCLFL 169
Query: 178 --PAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQLLAQ 235
+ + C + + + ++L+ ++++EV N L + +
Sbjct: 170 WVKQREGLVHLCCKKLKMLGMLFHNIRNILKTVNLDCIQEVEVNCNWTLPV--LAEFTPY 227
Query: 236 VGFPR-LASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFSTLTG 293
+G R L L L D Y S P+ + + + K+ L +L + + S L G
Sbjct: 228 LGQMRNLRKLVLS----DIDSRYIS-PEQKKEFVTQFTTQFLKLRCLQKLYMNSVSFLEG 282
Query: 294 KIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFR 353
+ +L L+T L +L + NC L +D+ L+ L+ LDLSG L +
Sbjct: 283 HLDQMLSCLKTSLNILAITNCVLLESDLKHLSKYPSIGQLKTLDLSGTRLANFSLVPLQV 342
Query: 354 LLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALC 413
LL + + TL L L++CGIVDS V ++ LS C L F GNP+S L L
Sbjct: 343 LLEKVAATLEYLDLDDCGIVDSQVNAILPALSRCFELTTFSFRGNPISTATLENLLCHTI 402
Query: 414 ELPELRCIE-FPVPKDCY 430
L L C+E +P P++ Y
Sbjct: 403 RLNNL-CLELYPAPRESY 419
>gi|88942379 PREDICTED: PRAME family member [Homo sapiens]
Length = 395
Score = 96.7 bits (239), Expect = 5e-20
Identities = 72/227 (31%), Positives = 112/227 (49%), Gaps = 18/227 (7%)
Query: 260 TPDGEDPLLASIARELSKMAQLTELSV-AFSTLTGKIPTLLGPLQTPLRVLDLANCALNH 318
+P+ + ++ + K+ L +L + + S L G + LL L+T L+VL + NC L
Sbjct: 168 SPEQKKEIVTQFTTQFLKLHCLQKLYMNSVSFLEGHLDQLLSCLKTSLKVLTITNCVLLE 227
Query: 319 TDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFRLLSQASRTLRILTLEECGIVDSHVG 378
+D+ L+ C + L+ LDLSG L + LL + + TL L L++CGI+DS V
Sbjct: 228 SDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDLDDCGIIDSQVN 287
Query: 379 MLILGLSPCHRLRQLKFLGNPLSARALRRLFTALCELPELRCIE-FPVPKDCYPEGAAYP 437
++ LS C L F GNP+S L L + L L C+E +P P++ Y GA
Sbjct: 288 AILPALSRCFELNTFSFCGNPISMATLENLLSHTIILKNL-CLELYPAPRESY--GA--- 341
Query: 438 QDELAMSKFNQQKYDEIAEELRAVLLRADREDIQVSTPLFGS-FDPD 483
L S+F Q +RA L++ R+ LFG+ + PD
Sbjct: 342 DGTLCWSRFTQ---------IRAELMKRVRDLRHPKRILFGTDYCPD 379
>gi|239741043 PREDICTED: PRAME family member 11 [Homo sapiens]
Length = 513
Score = 96.7 bits (239), Expect = 5e-20
Identities = 103/433 (23%), Positives = 184/433 (42%), Gaps = 36/433 (8%)
Query: 10 ISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLG 69
+ +L+ +A +L+ + L+P LF ++ + E + ++ WP L L+
Sbjct: 49 LXGRSLLRDQALAVSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLPLRPLI- 107
Query: 70 PGADHPQDLRDRTCRACLEALVRGLADHVLQD-RSRR-RLRVADLTGIRD----VQVQRC 123
C +A++ GL + Q R RR +L+V DL + + V +
Sbjct: 108 ----------KMPCLEAFQAVLDGLDALLTQGVRPRRWKLQVLDLQDVCENFWMVWSEAM 157
Query: 124 PCGRALGRWGRTQLLARTCCELQAEPLAAGRPVEVLADLFVTEGNFEAVVQALR---PAG 180
G L R + + C ++ +P+ V +L++ + + L
Sbjct: 158 AHGCFLNA-KRNKTPVQDCPRMRER-----QPLTVFVELWLKNRTLDEYLTCLLLWVKQR 211
Query: 181 PAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQLLAQVGFPR 240
L + C + + + +L++ ++++EV N + + Q +G R
Sbjct: 212 RDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEV--NCKWILPILTQFTPYLGHLR 269
Query: 241 -LASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFSTLTGKIPTL 298
L L L Y S P+ + ++ + K+ L +L + + S L G + L
Sbjct: 270 NLQKLVLSHMDVSR---YVS-PEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQL 325
Query: 299 LGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFRLLSQA 358
L L+T L+VL + NC L +D+ L+ C + L+ LDLSG L + LL +
Sbjct: 326 LSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKV 385
Query: 359 SRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALCELPEL 418
+ TL L L++CGI+DS V ++ LS C L F GNP+ L L + L L
Sbjct: 386 AATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTIILKNL 445
Query: 419 RCIE-FPVPKDCY 430
C+E +P P++ Y
Sbjct: 446 -CLELYPAPQESY 457
>gi|59958373 PRAME family member 4 [Homo sapiens]
Length = 478
Score = 96.7 bits (239), Expect = 5e-20
Identities = 105/439 (23%), Positives = 181/439 (41%), Gaps = 48/439 (10%)
Query: 10 ISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLG 69
++ +L+ +A +L+ + L+P LF ++ + E + ++ WP L L+
Sbjct: 14 LAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQSWPFRRLPLRPLI- 72
Query: 70 PGADHPQDLRDRTCRACLEALVRGLADHV-LQDRSRR-RLRVADLTGIRDVQVQRCPCGR 127
C +A++ GL + L R RR +L+V DL + C
Sbjct: 73 ----------KMPCLEAFQAVLDGLDALLNLGVRPRRWKLQVLDLQDV---------CEN 113
Query: 128 ALGRWGRTQLLARTCCELQAE---------PLAAGR-PVEVLADLFVTEGNFEAVVQALR 177
W C L A+ P GR P+ V +L++ + + L
Sbjct: 114 FWMVWSEAMAHG---CFLNAKRNKKPVEDCPRMRGRQPLTVFVELWLKNRTLDEYLTCLL 170
Query: 178 ---PAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQLLA 234
L + C + + + +L++ ++++EV N + + Q
Sbjct: 171 LWVKQRKDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEV--NCKWVLPILTQFTP 228
Query: 235 QVGFPR-LASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSV-AFSTLT 292
+G R L L L Y S P+ + ++ + K+ L +L + + S L
Sbjct: 229 YLGHMRNLQKLILSHMDVSR---YVS-PEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLE 284
Query: 293 GKIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFF 352
G + LL L+T L+ L + NC L +D+ L+ C + L+ LDLSG L +
Sbjct: 285 GHLDQLLSCLKTSLKFLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQ 344
Query: 353 RLLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTAL 412
LL + + TL L L++CGI+DS V ++ LS C L F GNP+ L L +
Sbjct: 345 ILLEKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHT 404
Query: 413 CELPELRCIE-FPVPKDCY 430
L L C+E +P P++ Y
Sbjct: 405 IILKNL-CVELYPAPRESY 422
>gi|226437621 PRAME family member 11 [Homo sapiens]
Length = 436
Score = 92.4 bits (228), Expect = 9e-19
Identities = 56/173 (32%), Positives = 89/173 (51%), Gaps = 3/173 (1%)
Query: 260 TPDGEDPLLASIARELSKMAQLTELSV-AFSTLTGKIPTLLGPLQTPLRVLDLANCALNH 318
+P+ + ++ + K+ L +L + + S L G + LL L+T L+VL + NC L
Sbjct: 209 SPEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQLLSCLKTSLKVLTITNCVLLE 268
Query: 319 TDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFRLLSQASRTLRILTLEECGIVDSHVG 378
+D+ L+ C + L+ LDLSG L + LL + + TL L L++CGI+DS V
Sbjct: 269 SDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDLDDCGIIDSQVN 328
Query: 379 MLILGLSPCHRLRQLKFLGNPLSARALRRLFTALCELPELRCIE-FPVPKDCY 430
++ LS C L F GNP+ L L + L L C+E +P P++ Y
Sbjct: 329 AILPALSRCFELNTFSFCGNPICMATLENLLSHTIILKNL-CLELYPAPQESY 380
>gi|194018546 PRAME family member 10 [Homo sapiens]
Length = 474
Score = 72.4 bits (176), Expect = 9e-13
Identities = 110/478 (23%), Positives = 192/478 (40%), Gaps = 45/478 (9%)
Query: 10 ISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLG 69
++ ++L+ + + +LD + ++PL+F ++ + + E + ++ WP LG+L+
Sbjct: 12 LAGQSLLRNQFLTIFTLDELPREVFPLMFMEAFSMRRFEALKLMVQAWPFLSLPLGSLM- 70
Query: 70 PGADHPQDLRDRTCRACLEALVRGLADHVLQD-RSRR-RLRVADLTGIRDVQVQRCPCGR 127
+ L T L+A++RGL V Q R RR +L+V DL + D G
Sbjct: 71 ------KTLHLET----LQAVLRGLDTLVAQKVRPRRWKLQVLDLRDV-DENFWTIWSGA 119
Query: 128 ALGRWGRTQLLARTCCELQAEPLAAGRPVEVLADLFVTEGNFEAVVQALRPAGPAPLR-- 185
+ + R E + +P++V DL + E + + L G R
Sbjct: 120 RVLSCSPEAMSKRQTVE-DCPRMGEHQPLKVFIDLCLKESTLDECLSYL--FGWIHYRRG 176
Query: 186 -VH--CPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLH-AGHVQQLLAQVGFPRL 241
VH C + S+ S ++L P ++++LEV L+ G L+Q+ R
Sbjct: 177 LVHLCCSKVQNYSMPTSSFRNLLERIYPDSIQELEVWKKCSLNKTGKFAPYLSQMSNLRE 236
Query: 242 ASLTLP-TKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSVAFSTLTGKIPTLLG 300
L + + PD + P L ++ + ++ S + + LL
Sbjct: 237 LFLAFGYERELYVSVQWPCIPDLDSPFLCLYYPQMLYIKKI-------SNIKEHLEHLLR 289
Query: 301 PLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFRLLSQASR 360
L+ PL ++ L DM L+ + L+ L L + + + LL + +
Sbjct: 290 YLKNPLGAFIFSDAYLTDRDMECLSQYPSLSQLKELRLIHILMWTTHLEPLGVLLEKVAA 349
Query: 361 TLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALCELPELRC 420
TL+ L L++C I D + +L+ LS C +L F GN S AL+ L L +L
Sbjct: 350 TLKTLVLKDCRIQDPQLRVLLPALSHCSQLTTFNFHGNETSMNALKDLLRHTGGLSKLGL 409
Query: 421 IEFPVPKDCYPEGAAYPQDELAMSKFNQQKYDEIAEELRAVLLRADREDIQVSTPLFG 478
+P P L + EI +RA L+R RE Q FG
Sbjct: 410 ELYPAP--------------LESLDYKGHVNWEILTPIRAELMRTLREVRQPKRIFFG 453
>gi|157426839 PRAME family member 17 [Homo sapiens]
Length = 474
Score = 69.7 bits (169), Expect = 6e-12
Identities = 99/423 (23%), Positives = 168/423 (39%), Gaps = 51/423 (12%)
Query: 26 LDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLGPGADHPQDLRDRTCRA 85
LD + ++PL+F + + E + ++ WP LG+L+ H + L
Sbjct: 28 LDELPREVFPLMFMEASSMRHFEALKLMVQAWPFLRLPLGSLMK--TPHLETL------- 78
Query: 86 CLEALVRGLADHVLQDRSRRRLRVADLTGIRDVQVQRCPCGRALGRWGRTQLLARTCCEL 145
+A+++GL D +L + R R + +RDV G W + L+ C
Sbjct: 79 --QAVLKGL-DTLLAQKLRPRRWKLQVLDLRDVD------GNFWTIWSGARALS---CSP 126
Query: 146 QAEP----------LAAGRPVEVLADLFVTEGNFEAVVQAL-RPAGPAPLRVH--CPSFR 192
+A +P++V DL E + + L R VH C +
Sbjct: 127 EAMSKRQTVEDYPRTGEHQPLKVFIDLCQKESTLDECLSYLCRWIHYRRGLVHLCCNKVQ 186
Query: 193 ADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLH-AGHVQQLLAQVGFPRLASLTLPTKAF 251
S+ S ++L+ P ++++LE+ L+ G L+Q+ R L +
Sbjct: 187 NYSMPTSSFRNLLKRVYPDSIQELEIKRKCSLNKTGKFAPYLSQMSNLRKLFLAF---GY 243
Query: 252 DAPPTYAS-----TPDGEDPLLASIARELSKMAQLTELSVAFSTLTGKIPTLLGPLQTPL 306
D Y S PD + P L ++ + ++ S + + LL L+ PL
Sbjct: 244 D-DELYVSGQQQFVPDLDCPFLCLYYPQMLYIRKI-------SNIKEHLEHLLRCLKNPL 295
Query: 307 RVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFRLLSQASRTLRILT 366
+ L DM L+ + L+ L L + + LL + + TL ILT
Sbjct: 296 GTFIFCHAYLADQDMECLSQYPSLSQLKELHLIHILMWTTNLEPLGALLEKVAATLEILT 355
Query: 367 LEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALCELPELRCIEFPVP 426
L++C I DS + +L+ LS C +L F GN S AL+ L L +L +P P
Sbjct: 356 LKDCQIQDSQLRVLLPALSRCSQLTTFYFRGNETSTNALKDLLCHTGGLSKLGLELYPAP 415
Query: 427 KDC 429
+C
Sbjct: 416 LEC 418
>gi|113865933 PRAME family member 16 [Homo sapiens]
Length = 474
Score = 69.7 bits (169), Expect = 6e-12
Identities = 97/420 (23%), Positives = 168/420 (40%), Gaps = 45/420 (10%)
Query: 26 LDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRLGALLGPGADHPQDLRDRTCRA 85
LD + ++PL+F + + E + ++ WP LG+L+ H + L
Sbjct: 28 LDELPREVFPLMFMEASSMRHFEALKLMVQAWPFLRLPLGSLMK--TPHLETL------- 78
Query: 86 CLEALVRGLADHVLQDRSRRRLRVADLTGIRDVQVQRCPCGRALGRWGRTQLLARTCCEL 145
+A+++GL D +L + R R + +RDV G W + L+ + +
Sbjct: 79 --QAVLKGL-DTLLAQKLRPRRWKLQVLDLRDVD------GNFWTIWSGARALSCSPEAM 129
Query: 146 QAEPLAAG-------RPVEVLADLFVTEGNFEAVVQAL-RPAGPAPLRVH--CPSFRADS 195
+ +P++V DL E + + L R VH C + S
Sbjct: 130 RKRQTVEDYPRTGEHQPLKVFIDLCQKESTLDECLSYLCRWIHYRRGLVHLCCNKVQNYS 189
Query: 196 LSPSQLLHVLRLAGPGALRKLEVVHNVRLH-AGHVQQLLAQVGFPRLASLTLPTKAFDAP 254
+ S ++L+ P ++++LE+ L+ G L+Q+ R L +D
Sbjct: 190 MPTSSFRNLLKRVYPDSIQELEIKRKCSLNKTGKFAPYLSQMSNLRKLFLAF---GYD-D 245
Query: 255 PTYAS-----TPDGEDPLLASIARELSKMAQLTELSVAFSTLTGKIPTLLGPLQTPLRVL 309
Y S PD + P L ++ + ++ S + + LL L+ PL
Sbjct: 246 ELYVSGQQQFVPDLDCPFLCLYYPQMLYIRKI-------SNIKEHLEHLLRCLKNPLGTF 298
Query: 310 DLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTFFRLLSQASRTLRILTLEE 369
+ L DM L+ + L+ L L + + LL + + TL ILTL++
Sbjct: 299 IFCHAYLADQDMECLSQYPSLSQLKELHLIHILMWTTNLEPLGALLEKVAATLEILTLKD 358
Query: 370 CGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTALCELPELRCIEFPVPKDC 429
C I DS + +L+ LS C +L F GN S AL+ L L +L +P P +C
Sbjct: 359 CQIQDSQLRVLLPALSRCSQLTTFYFRGNETSTNALKDLLCHTGGLSKLGLELYPAPLEC 418
>gi|194306638 PRAME family member 3 [Homo sapiens]
Length = 481
Score = 68.2 bits (165), Expect = 2e-11
Identities = 103/437 (23%), Positives = 175/437 (40%), Gaps = 39/437 (8%)
Query: 5 RSLRFISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLLEQAEVTRAVLGRWPLEEFRL 64
R L ++ ++L+ +A LD + L+P LF ++ + EV + ++ WP L
Sbjct: 9 RRLLELAGQSLLGDQALAISILDELPRELFPPLFVEAFTSRRCEVLKVMVQAWPFPCLPL 68
Query: 65 GALLGPGADHPQDLRDRTCRACLEALVRGLADHVLQDRSRRRLRVADLTGIRDVQ----- 119
G+L+ DL L +V G+ D +L + R R R + +RDV
Sbjct: 69 GSLM-----KTPDLE------ILHYVVDGI-DCLLAQKVRPRRRKLQVLELRDVDENFWT 116
Query: 120 ----VQRCPCG-RALGRWGRTQLLARTCCELQAEPLAAGRPVEVLADLFVTE--GNFEAV 172
+ C A+ + + RT + +PL V L + F+ E F
Sbjct: 117 IWSGARPLSCSPEAMSKRQTVEDCPRTG---EKQPLKVFMDV-CLKEKFMDEDLSFFSGW 172
Query: 173 VQALRPAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEVVHNVRLHAGHVQQL 232
VQ R + + + C S+S ++L P +++ LE+ N+ V+ +
Sbjct: 173 VQHRRGS----VHLCCTKVVNYSMSILNFRNILETVYPDSIQVLEI-WNMCWPCMIVEFI 227
Query: 233 LAQVGFPRLASLTLPTKAFDAPPTYASTPDGEDPLLASIARELSKMAQLTELSVA-FSTL 291
L L + Y + D ++ L+A + L ++ L L V
Sbjct: 228 RYLSQMRNLRKLFISDGC-----RYLLSSDSQEQLVAEFSSVLLRLEYLQMLYVRRVCFF 282
Query: 292 TGKIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLEVLDLSGHNLVSLYPSTF 351
G + L+ L++PL L L L D+ L + L+ L+LS L +
Sbjct: 283 RGHLDQLIRCLRSPLETLALTYGFLEKVDLKCLPRYPSLSQLKQLNLSHGALRFIRLEPL 342
Query: 352 FRLLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQLKFLGNPLSARALRRLFTA 411
LL + + TL+ L L +CGI DS + +++ LS C L F GN S L+ L
Sbjct: 343 RALLEKVAATLQTLFLVDCGIRDSKLRVILPALSCCSNLTTFCFHGNDTSMDGLKDLLRH 402
Query: 412 LCELPELRCIEFPVPKD 428
L L +P P++
Sbjct: 403 TGRLSNLSLETYPAPRE 419
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,582,895
Number of Sequences: 37866
Number of extensions: 823471
Number of successful extensions: 2337
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 2183
Number of HSP's gapped (non-prelim): 136
length of query: 514
length of database: 18,247,518
effective HSP length: 107
effective length of query: 407
effective length of database: 14,195,856
effective search space: 5777713392
effective search space used: 5777713392
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.