Search of human proteins with 122937315

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|122937315 leucine-rich repeats and IQ motif containing 4
[Homo sapiens]
         (560 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom...  1123   0.0  
gi|238908508 leucine-rich repeat and death domain-containing pro...   210   2e-54
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]          193   3e-49
gi|16904383 leucine rich repeat containing 7 [Homo sapiens]           176   5e-44
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]        173   3e-43
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]         173   3e-43
gi|95113664 leucine rich repeat containing 1 [Homo sapiens]           169   5e-42
gi|110825984 malignant fibrous histiocytoma amplified sequence 1...   166   7e-41
gi|45827729 scribble isoform b [Homo sapiens]                         160   3e-39
gi|45827731 scribble isoform a [Homo sapiens]                         160   3e-39
gi|21361633 leucine rich repeat containing 40 [Homo sapiens]          152   8e-37
gi|4503743 flightless I homolog [Homo sapiens]                        147   3e-35
gi|62241040 leucine rich repeat containing 8 family, member A [H...   124   2e-28
gi|187829877 leucine rich repeat containing 8 family, member A [...   124   2e-28
gi|187829871 leucine rich repeat containing 8 family, member A [...   124   2e-28
gi|225579152 insulin-like growth factor binding protein, acid la...   117   2e-26
gi|4826772 insulin-like growth factor binding protein, acid labi...   117   2e-26
gi|40217803 leucine rich repeat containing 8 family, member E [H...   114   2e-25
gi|157743290 leucine rich repeat containing 30 [Homo sapiens]         114   3e-25
gi|193788651 leucine rich repeat containing 69 [Homo sapiens]         111   2e-24
gi|37221175 PH domain and leucine rich repeat protein phosphatas...   110   3e-24
gi|197333706 leucine rich repeat containing 8 family, member D [...   109   6e-24
gi|34222199 leucine rich repeat containing 8 family, member D [H...   109   6e-24
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]   108   1e-23
gi|45505137 podocan [Homo sapiens]                                    107   4e-23
gi|197333692 leucine rich repeat containing 8 family, member B [...   106   6e-23
gi|21245134 leucine rich repeat containing 8 family, member B [H...   106   6e-23
gi|65301141 PH domain and leucine rich repeat protein phosphatas...   105   1e-22
gi|190014581 leucine rich repeat containing 2 [Homo sapiens]          102   1e-21
gi|27545328 leucine rich repeat containing 2 [Homo sapiens]           102   1e-21

>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
           sapiens]
          Length = 560

 Score = 1123 bits (2904), Expect = 0.0
 Identities = 560/560 (100%), Positives = 560/560 (100%)

Query: 1   MSKDIKSVEHSPKIHQRNDPQHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQI 60
           MSKDIKSVEHSPKIHQRNDPQHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQI
Sbjct: 1   MSKDIKSVEHSPKIHQRNDPQHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQI 60

Query: 61  EEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHAL 120
           EEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHAL
Sbjct: 61  EEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHAL 120

Query: 121 RELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVF 180
           RELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVF
Sbjct: 121 RELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVF 180

Query: 181 PQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLD 240
           PQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLD
Sbjct: 181 PQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLD 240

Query: 241 LSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFR 300
           LSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFR
Sbjct: 241 LSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFR 300

Query: 301 CLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNE 360
           CLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNE
Sbjct: 301 CLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNE 360

Query: 361 FLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSM 420
           FLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSM
Sbjct: 361 FLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSM 420

Query: 421 PNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPME 480
           PNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPME
Sbjct: 421 PNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPME 480

Query: 481 EPPKEVCAEGNEAIWKYLKENRNRNIMATKIQAWWRGTMVQRGFGKFGELLKPQKKGKTS 540
           EPPKEVCAEGNEAIWKYLKENRNRNIMATKIQAWWRGTMVQRGFGKFGELLKPQKKGKTS
Sbjct: 481 EPPKEVCAEGNEAIWKYLKENRNRNIMATKIQAWWRGTMVQRGFGKFGELLKPQKKGKTS 540

Query: 541 PKDKKGKKDVKGKPGKGKKK 560
           PKDKKGKKDVKGKPGKGKKK
Sbjct: 541 PKDKKGKKDVKGKPGKGKKK 560


>gi|238908508 leucine-rich repeat and death domain-containing
           protein [Homo sapiens]
          Length = 860

 Score =  210 bits (535), Expect = 2e-54
 Identities = 144/474 (30%), Positives = 237/474 (50%), Gaps = 11/474 (2%)

Query: 37  LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96
           LT  P  +    +L  + L  N I  +P+EI+ LKN+  L +D N L  L   +  L  +
Sbjct: 292 LTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKI 351

Query: 97  ESLDLSYNPIFSSSLVVVSFLHALRELRLYQTD---LKEIPVVIFKNLHHLELLGLTGNH 153
           + L L+ N +   S  + +F    RELR+   D   LK IP  I      LE L L+ N 
Sbjct: 352 KELQLADNKLEVISHKIENF----RELRILILDKNLLKNIPEKI-SCCAMLECLSLSDNK 406

Query: 154 LKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGL 213
           L  LPK I     LR++++ RN        +  L  +  ++   N I  +P EI +   +
Sbjct: 407 LTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKI 466

Query: 214 QKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVP 273
            K  ++ N +   P  LC    L  L ++ N +  IP   +  +++  + LS N+L    
Sbjct: 467 IKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFS 526

Query: 274 RLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGL 333
              C   +L  L LG   + ++  S   +++L  L L  N     P ++C L+NL+VL L
Sbjct: 527 EHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDL 586

Query: 334 DDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEH 393
            +N++ ++ S++ +L  ++ L  + N+F+ FP E+  L SLE+L I Q +G KLT +P  
Sbjct: 587 SENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGE 646

Query: 394 IRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLED 453
           +  +  LKEL I NN +  +P ++G + NL  L   +N +  LP ++     L++L L  
Sbjct: 647 LSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSG 706

Query: 454 NLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNE--AIWKYLKENRNRN 505
           N LT LP  + ++ +LK +   DNP+  PP E+C +G +   I +YL+    R+
Sbjct: 707 NNLTALPSAIYNIFSLKEINFDDNPLLRPPVEIC-KGKQLYTIARYLQRADERD 759



 Score =  177 bits (448), Expect = 3e-44
 Identities = 129/457 (28%), Positives = 219/457 (47%), Gaps = 33/457 (7%)

Query: 30  IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
           +   NQ    +  + FT      V+LE   ++E P++I ++K ++ LYLDKN +++   A
Sbjct: 129 VSEENQKQLGLGADNFT------VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGA 182

Query: 90  LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
                  +S DL                  L  L L +  L  +P  I + LH+L +L +
Sbjct: 183 -------DSGDLL----------------GLEILSLQENGLSSLPSEI-QLLHNLRILNV 218

Query: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGH 209
           + NH+  +PKEI     +R+++   N  E FP +L  L  LEI+ L +NK+  IP+ +  
Sbjct: 219 SHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPS 278

Query: 210 LTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRL 269
           L  L+   +  N L   P +LC   +L  LDL+ NL+ S+PK   EL+ +  + +  N+L
Sbjct: 279 LKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKL 338

Query: 270 EKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLE 329
             +   I +   +  L L +  L  +         LR L L +N L + P +I     LE
Sbjct: 339 TFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLE 398

Query: 330 VLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTY 389
            L L DNK+ +LP  +  L+ L+ L +  N  +   + +  L ++  L   +  G  +T 
Sbjct: 399 CLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSL---EFSGNIITD 455

Query: 390 VPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKEL 449
           VP  I+  Q + ++ +  N + Y P+ L ++ +L  L    N + ++P  I  ++ L  L
Sbjct: 456 VPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHL 515

Query: 450 RLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486
            L +N L    E+  SL+NLK L L  N +++ P  +
Sbjct: 516 ELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASI 552



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 66/258 (25%), Positives = 110/258 (42%), Gaps = 26/258 (10%)

Query: 30  IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
           ++ S   L        +   L+ + L  NQI++IP  I  + ++ VL L  N   +    
Sbjct: 515 LELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE 574

Query: 90  LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVI--FKNLHHLELL 147
           L  L +L+ LDLS N +   S  + + L  +++L          P+ +   ++L  L + 
Sbjct: 575 LCTLENLQVLDLSENQLQKISSDICN-LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNIS 633

Query: 148 GLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEI 207
            + G  L  LP E+ N T+L+E                       +D+  N I  IP  I
Sbjct: 634 QIKGRKLTRLPGELSNMTQLKE-----------------------LDISNNAIREIPRNI 670

Query: 208 GHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGN 267
           G L  L   +  +N +  LP SL   + L  L+LS N L ++P +   +  + EI    N
Sbjct: 671 GELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDN 730

Query: 268 RLEKVPRLICRWTSLHLL 285
            L + P  IC+   L+ +
Sbjct: 731 PLLRPPVEICKGKQLYTI 748



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 52/181 (28%), Positives = 85/181 (46%), Gaps = 27/181 (14%)

Query: 308 LDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLP-SELGSLSKLKILGLTGNEFLSFPE 366
           ++L    L   P  I  +K ++ L LD N+I     ++ G L  L+IL L  N   S P 
Sbjct: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPS 205

Query: 367 EVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVL 426
           E+  L +L  L +  +    ++++P+ I +L ++++L+  NN++E  P  L  + NLE+L
Sbjct: 206 EIQLLHNLRILNVSHNH---ISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEIL 262

Query: 427 DCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486
                                   L  N L H+P+ L SL  L+VL L  N +   PK +
Sbjct: 263 S-----------------------LGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKAL 299

Query: 487 C 487
           C
Sbjct: 300 C 300



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 35/120 (29%), Positives = 63/120 (52%), Gaps = 2/120 (1%)

Query: 391 PEHIRKLQSLKELYIENNHLE-YLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKEL 449
           P+ I K++ +K LY++ N ++ +     G +  LE+L  + N L  LP  I     L+ L
Sbjct: 157 PKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRIL 216

Query: 450 RLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRNRNIMAT 509
            +  N ++H+P+ +  L N++ L   +N +E  P ++   GN  I   L +N+ R+I  T
Sbjct: 217 NVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILS-LGKNKLRHIPDT 275


>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
          Length = 582

 Score =  193 bits (491), Expect = 3e-49
 Identities = 140/453 (30%), Positives = 227/453 (50%), Gaps = 33/453 (7%)

Query: 30  IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
           +D S +S+  +P  I   T+L E++L +N+++ +P E+  L N+  L L +N+L SL  +
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164

Query: 90  LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
           L  L  L  LDL +N                         L+EIP V+++ L  L  L L
Sbjct: 165 LDNLKKLRMLDLRHN------------------------KLREIPSVVYR-LDSLTTLYL 199

Query: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGH 209
             N +  + K+I N +KL  + ++ N+ +  P E+  L  L  +D+  N++  +P+EIG+
Sbjct: 200 RFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGN 259

Query: 210 LTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRL 269
            T +    +  N L  LP ++   S LS L L +N L +IP+S A+   + E+ L  N +
Sbjct: 260 CTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNI 319

Query: 270 EKVPR-LICRWTSLHLLYLGNT--GLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICA-L 325
             +P  L+     L+ L L      L+ + G  +    +  L++  N ++  P  I +  
Sbjct: 320 STLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ-FSTIYSLNMEHNRINKIPFGIFSRA 378

Query: 326 KNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGF 385
           K L  L + DN++  LP + G+ + +  L L  N+    PE+V  L SLE L +  +   
Sbjct: 379 KVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNN--- 435

Query: 386 KLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQA 445
            L  +P  +  L+ L+EL +E N LE LP  +  + +L+ L   +N L  LP  I     
Sbjct: 436 LLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTN 495

Query: 446 LKELRLEDNLLTHLPENLDSLVNLKVLTLMDNP 478
           L  L L +NLLTHLPE + +L NL+ L L DNP
Sbjct: 496 LTHLGLGENLLTHLPEEIGTLENLEELYLNDNP 528



 Score =  139 bits (349), Expect = 9e-33
 Identities = 103/361 (28%), Positives = 172/361 (47%), Gaps = 29/361 (8%)

Query: 37  LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96
           +T +  +I   ++L  + +  N+I+++P EI  L N+  L +  N L  L   +G  + +
Sbjct: 204 ITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQI 263

Query: 97  ESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKC 156
            +LDL +N +      + + L +L  L L    L  IP  + K    LE L L  N++  
Sbjct: 264 TNLDLQHNELLDLPDTIGN-LSSLSRLGLRYNRLSAIPRSLAK-CSALEELNLENNNIST 321

Query: 157 LPKEIVNQ-TKLREIYLKRNQFEVFP----QELCVLYTLEI------------------- 192
           LP+ +++   KL  + L RN F+++P     +   +Y+L +                   
Sbjct: 322 LPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVL 381

Query: 193 --IDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIP 250
             +++ +N++ ++P + G  T + +  +A+N L  +P  +     L VL LS+NLL  +P
Sbjct: 382 SKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLP 441

Query: 251 KSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDL 310
                LRK+ E+ L  N+LE +P  I     L  L L N  L  L      L NL  L L
Sbjct: 442 HGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGL 501

Query: 311 SQNHLHHCPLQICALKNLEVLGLDDN-KIGQLPSELGSLSKLKILGLTGNEFLSFPEEVL 369
            +N L H P +I  L+NLE L L+DN  +  LP EL   SKL I+ +        P +++
Sbjct: 502 GENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIV 561

Query: 370 S 370
           +
Sbjct: 562 A 562



 Score =  138 bits (348), Expect = 1e-32
 Identities = 93/320 (29%), Positives = 157/320 (49%), Gaps = 29/320 (9%)

Query: 193 IDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKS 252
           +DL +  I  +P  I  LT L + Y+ SN L  LPA +     L  L LS N L S+P S
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164

Query: 253 FAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQ 312
              L+K+  + L  N+L ++P ++ R  SL  LYL    +  +    + L  L  L + +
Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224

Query: 313 NHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLA 372
           N +   P +I  L NL  L +  N++  LP E+G+ +++  L L  NE L  P+ + +L+
Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284

Query: 373 SLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSL--------------- 417
           SL +L +  +   +L+ +P  + K  +L+EL +ENN++  LP SL               
Sbjct: 285 SLSRLGLRYN---RLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARN 341

Query: 418 ----------GSMPNLEVLDCRHNLLKQLPDAI-CQAQALKELRLEDNLLTHLPENLDSL 466
                          +  L+  HN + ++P  I  +A+ L +L ++DN LT LP +  + 
Sbjct: 342 CFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTW 401

Query: 467 VNLKVLTLMDNPMEEPPKEV 486
            ++  L L  N + + P++V
Sbjct: 402 TSMVELNLATNQLTKIPEDV 421



 Score =  130 bits (327), Expect = 3e-30
 Identities = 99/363 (27%), Positives = 167/363 (46%), Gaps = 23/363 (6%)

Query: 147 LGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEE 206
           L L+   +  LP  I   T+L E+YL  N+ +  P E+  L  L  + L EN + ++P+ 
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164

Query: 207 IGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSG 266
           + +L  L+   +  N L  +P+ + +   L+ L L  N + ++ K    L K++ + +  
Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224

Query: 267 NRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALK 326
           N+++++P  I    +L  L + +  L  L         +  LDL  N L   P  I  L 
Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284

Query: 327 NLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVL-SLASLEKLY------- 378
           +L  LGL  N++  +P  L   S L+ L L  N   + PE +L SL  L  L        
Sbjct: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344

Query: 379 ---IGQDQGFKLTYV--PEHIR----------KLQSLKELYIENNHLEYLPVSLGSMPNL 423
              +G    F   Y    EH R          + + L +L +++N L  LP+  G+  ++
Sbjct: 345 LYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSM 404

Query: 424 EVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPP 483
             L+   N L ++P+ +    +L+ L L +NLL  LP  L +L  L+ L L +N +E  P
Sbjct: 405 VELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLP 464

Query: 484 KEV 486
            E+
Sbjct: 465 NEI 467


>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
          Length = 1537

 Score =  176 bits (446), Expect = 5e-44
 Identities = 119/379 (31%), Positives = 187/379 (49%), Gaps = 4/379 (1%)

Query: 99  LDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLP 158
           LD S+  +      V +F   L EL L    ++E+P  +F N   L  L +  N L  LP
Sbjct: 27  LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLSNLP 85

Query: 159 KEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYM 218
             I +   L+E+ + +N  + FP+ +     L II+   N I  +P+    L  L + Y+
Sbjct: 86  TTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYL 145

Query: 219 ASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICR 278
               L  LPA+  +  +L +L+L  N L ++PKS  +L ++  + L  N   ++P ++ +
Sbjct: 146 NDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQ 205

Query: 279 WTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKI 338
             +L  L++ N  L  L GS   L  L +LD+S+N +    + I   + LE L L  N +
Sbjct: 206 IQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNML 265

Query: 339 GQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQ 398
            QLP  +G L KL  L +  N+    P  + +L+ LE+     ++   L  +P  I  L 
Sbjct: 266 QQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNE---LESLPSTIGYLH 322

Query: 399 SLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTH 458
           SL+ L ++ N L  LP  +GS  N+ V+  R N L+ LP+ I Q Q L+ L L DN L +
Sbjct: 323 SLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKN 382

Query: 459 LPENLDSLVNLKVLTLMDN 477
           LP +   L  L  L L DN
Sbjct: 383 LPFSFTKLKELAALWLSDN 401



 Score =  158 bits (399), Expect = 1e-38
 Identities = 114/377 (30%), Positives = 182/377 (48%), Gaps = 24/377 (6%)

Query: 30  IDASNQSLTAIPLEIFTFTE-LEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           +D S+ SL  +P E+F F   LEE++L+ NQIEE+P+++   + +R L +  N+L +L  
Sbjct: 27  LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPT 86

Query: 89  ALGLLSSLESLDLSYN---------------PIFSSSLVVVS-----FLHALRELRLYQT 128
            +  L +L+ LD+S N                I  +S+  +S     F   L   +LY  
Sbjct: 87  TIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN 146

Query: 129 D--LKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCV 186
           D  L+ +P   F  L  L +L L  NHLK LPK +    +L  + L  N+F   P+ L  
Sbjct: 147 DAFLEFLPAN-FGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQ 205

Query: 187 LYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLL 246
           +  L  + +D N +  +P  IG L  L    M+ N +  +   +  C  L  L LS N+L
Sbjct: 206 IQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNML 265

Query: 247 HSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLR 306
             +P S   L+K+T + +  N+L  +P  I   + L         L  L  +   L +LR
Sbjct: 266 QQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLR 325

Query: 307 FLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPE 366
            L + +N L   P +I + KN+ V+ L  NK+  LP E+G + KL++L L+ N   + P 
Sbjct: 326 TLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPF 385

Query: 367 EVLSLASLEKLYIGQDQ 383
               L  L  L++  +Q
Sbjct: 386 SFTKLKELAALWLSDNQ 402



 Score =  158 bits (399), Expect = 1e-38
 Identities = 101/354 (28%), Positives = 176/354 (49%), Gaps = 5/354 (1%)

Query: 154 LKCLPKEIVN-QTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTG 212
           L+ +PKE+ N +  L E+YL  NQ E  P++L     L  + + +N +  +P  I  L  
Sbjct: 34  LQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVN 93

Query: 213 LQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKV 272
           L++  ++ N +   P ++  C  L++++ S N +  +P  F +L  +T++ L+   LE +
Sbjct: 94  LKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFL 153

Query: 273 PRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLG 332
           P    R   L +L L    L  L  S   L  L  LDL  N     P  +  ++NL  L 
Sbjct: 154 PANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELW 213

Query: 333 LDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPE 392
           +D+N +  LP  +G L  L  L ++ N   +   ++    +LE L +  +    L  +P+
Sbjct: 214 MDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNM---LQQLPD 270

Query: 393 HIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLE 452
            I  L+ L  L +++N L  LP ++G++  LE  DC  N L+ LP  I    +L+ L ++
Sbjct: 271 SIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVD 330

Query: 453 DNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRNRNI 506
           +N L  LP  + S  N+ V++L  N +E  P+E+  +  +     L +NR +N+
Sbjct: 331 ENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEI-GQMQKLRVLNLSDNRLKNL 383



 Score =  122 bits (307), Expect = 7e-28
 Identities = 88/285 (30%), Positives = 144/285 (50%), Gaps = 32/285 (11%)

Query: 231 CQCSQ-----LSVLDLSHNLLHSIPKS-FAELRKMTEIGLSGNRLEKVPRLICRWTSLHL 284
           C+C +     +SVLD SH  L  +PK  F   R + E+ L  N++E++P+ +    +L  
Sbjct: 14  CRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRK 73

Query: 285 LYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALK------------------ 326
           L + +  L  L  +   LVNL+ LD+S+N +   P  I   K                  
Sbjct: 74  LSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDG 133

Query: 327 -----NLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQ 381
                NL  L L+D  +  LP+  G L KL+IL L  N   + P+ +  LA LE+L +G 
Sbjct: 134 FTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGN 193

Query: 382 DQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAIC 441
           ++  +L   PE + ++Q+L+EL+++NN L+ LP S+G +  L  LD   N ++ +   I 
Sbjct: 194 NEFGEL---PEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDIS 250

Query: 442 QAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486
             +AL++L L  N+L  LP+++  L  L  L + DN +   P  +
Sbjct: 251 GCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTI 295



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 52/175 (29%), Positives = 89/175 (50%), Gaps = 2/175 (1%)

Query: 29  FIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           ++D S   +  + ++I     LE++ L +N ++++P  I  LK +  L +D N L  L  
Sbjct: 234 YLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPN 293

Query: 89  ALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLG 148
            +G LS LE  D S N +  S    + +LH+LR L + +  L E+P  I  +  ++ ++ 
Sbjct: 294 TIGNLSLLEEFDCSCNEL-ESLPSTIGYLHSLRTLAVDENFLPELPREI-GSCKNVTVMS 351

Query: 149 LTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAI 203
           L  N L+ LP+EI    KLR + L  N+ +  P     L  L  + L +N+  A+
Sbjct: 352 LRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406


>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
          Length = 1302

 Score =  173 bits (439), Expect = 3e-43
 Identities = 118/420 (28%), Positives = 206/420 (49%), Gaps = 12/420 (2%)

Query: 95  SLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHL 154
           ++ +LD S+  +      + +F   L EL L    ++E+P  +F N   L  L L  N L
Sbjct: 23  TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDL 81

Query: 155 KCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQ 214
             LP  I N   LRE+ + +N  + FP+ +     L I++   N I  +P+    L  L 
Sbjct: 82  TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141

Query: 215 KFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPR 274
           + Y+    L  LPA+  + ++L +L+L  N L  +PK+   L ++  + L  N   +VP 
Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201

Query: 275 LICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLD 334
           ++ + + L   ++    L  + G    L  L +LD+S+N++      I   +NL+ L L 
Sbjct: 202 VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261

Query: 335 DNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGF-KLTYVPEH 393
            N + QLP  +GSL  +  L +  N+ +  P+ +  L S+E+L    D  F ++  +P  
Sbjct: 262 SNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEEL----DCSFNEVEALPSS 317

Query: 394 IRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLED 453
           I +L +L+    ++N+L+ LP  +GS  N+ VL    N L+ LP+ +   Q LK + L D
Sbjct: 318 IGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSD 377

Query: 454 NLLTHLPENLDSLVNLKVLTLMDN---PMEEPPKEVCAEGNEAI---WKYLKENRNRNIM 507
           N L +LP +   L  L  + L DN   P+    KE  +E  + +   + + ++ R  ++M
Sbjct: 378 NRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVM 437



 Score =  165 bits (417), Expect = 1e-40
 Identities = 114/382 (29%), Positives = 196/382 (51%), Gaps = 10/382 (2%)

Query: 30  IDASNQSLTAIPLEIFTFTE-LEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           +D S+ SL  +P EIFTF + LEE++L+ NQIEE+P+++   +++  L L  N+L +L  
Sbjct: 27  LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86

Query: 89  ALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVI--FKNLHHLEL 146
           ++  L +L  LD+S N I      + +     + L + +  +  I  +   F  L +L  
Sbjct: 87  SIANLINLRELDVSKNGIQEFPENIKN----CKVLTIVEASVNPISKLPDGFSQLLNLTQ 142

Query: 147 LGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEE 206
           L L    L+ LP      TKL+ + L+ NQ ++ P+ +  L  LE +DL  N+   +PE 
Sbjct: 143 LYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV 202

Query: 207 IGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSG 266
           +  L+GL++F+M +N L  +P  +    QL+ LD+S N +  + +  +    + ++ LS 
Sbjct: 203 LEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSS 262

Query: 267 NRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALK 326
           N L+++P  I    ++  L +    L  L  S   L+++  LD S N +   P  I  L 
Sbjct: 263 NSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT 322

Query: 327 NLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFK 386
           NL     D N + QLP E+GS   + +L L  N+  + PEE   +  ++KL +      +
Sbjct: 323 NLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE---MGDMQKLKVINLSDNR 379

Query: 387 LTYVPEHIRKLQSLKELYIENN 408
           L  +P    KLQ L  +++ +N
Sbjct: 380 LKNLPFSFTKLQQLTAMWLSDN 401



 Score =  158 bits (400), Expect = 1e-38
 Identities = 108/362 (29%), Positives = 182/362 (50%), Gaps = 7/362 (1%)

Query: 154 LKCLPKEIVNQTK-LREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTG 212
           L+ +PKEI    K L E+YL  NQ E  P++L    +L  + L +N +  +P  I +L  
Sbjct: 34  LEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLIN 93

Query: 213 LQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKV 272
           L++  ++ N +   P ++  C  L++++ S N +  +P  F++L  +T++ L+   LE +
Sbjct: 94  LRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFL 153

Query: 273 PRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLG 332
           P    R T L +L L    L  L  +   L  L  LDL  N     P  +  L  L+   
Sbjct: 154 PANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFW 213

Query: 333 LDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPE 392
           +D N++  +P  +GSL +L  L ++ N      E + +  +L+ L +  +    L  +PE
Sbjct: 214 MDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNS---LQQLPE 270

Query: 393 HIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLE 452
            I  L+++  L I+ N L YLP S+G + ++E LDC  N ++ LP +I Q   L+    +
Sbjct: 271 TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAAD 330

Query: 453 DNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRNRNI--MATK 510
            N L  LP  + S  N+ VL L  N +E  P+E+  +  +     L +NR +N+    TK
Sbjct: 331 HNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEM-GDMQKLKVINLSDNRLKNLPFSFTK 389

Query: 511 IQ 512
           +Q
Sbjct: 390 LQ 391



 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 55/225 (24%), Positives = 110/225 (48%), Gaps = 26/225 (11%)

Query: 29  FIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           ++D S  ++  +   I T   L+++ L +N ++++P+ I  LKNI  L +D+N L  L  
Sbjct: 234 YLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPD 293

Query: 89  ALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLG 148
           ++G L S+E LD S+N + +    + S +  L  LR +  D                   
Sbjct: 294 SIGGLISVEELDCSFNEVEA----LPSSIGQLTNLRTFAAD------------------- 330

Query: 149 LTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIG 208
              N+L+ LP EI +   +  ++L  N+ E  P+E+  +  L++I+L +N++  +P    
Sbjct: 331 --HNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFT 388

Query: 209 HLTGLQKFYMASN-NLPVLPASLCQCSQLSVLDLSHNLLHSIPKS 252
            L  L   +++ N + P++P      S+   + L++ +    P++
Sbjct: 389 KLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRT 433


>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
          Length = 1371

 Score =  173 bits (439), Expect = 3e-43
 Identities = 118/420 (28%), Positives = 206/420 (49%), Gaps = 12/420 (2%)

Query: 95  SLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHL 154
           ++ +LD S+  +      + +F   L EL L    ++E+P  +F N   L  L L  N L
Sbjct: 23  TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDL 81

Query: 155 KCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQ 214
             LP  I N   LRE+ + +N  + FP+ +     L I++   N I  +P+    L  L 
Sbjct: 82  TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141

Query: 215 KFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPR 274
           + Y+    L  LPA+  + ++L +L+L  N L  +PK+   L ++  + L  N   +VP 
Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201

Query: 275 LICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLD 334
           ++ + + L   ++    L  + G    L  L +LD+S+N++      I   +NL+ L L 
Sbjct: 202 VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261

Query: 335 DNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGF-KLTYVPEH 393
            N + QLP  +GSL  +  L +  N+ +  P+ +  L S+E+L    D  F ++  +P  
Sbjct: 262 SNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEEL----DCSFNEVEALPSS 317

Query: 394 IRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLED 453
           I +L +L+    ++N+L+ LP  +GS  N+ VL    N L+ LP+ +   Q LK + L D
Sbjct: 318 IGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSD 377

Query: 454 NLLTHLPENLDSLVNLKVLTLMDN---PMEEPPKEVCAEGNEAI---WKYLKENRNRNIM 507
           N L +LP +   L  L  + L DN   P+    KE  +E  + +   + + ++ R  ++M
Sbjct: 378 NRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVM 437



 Score =  165 bits (417), Expect = 1e-40
 Identities = 114/382 (29%), Positives = 196/382 (51%), Gaps = 10/382 (2%)

Query: 30  IDASNQSLTAIPLEIFTFTE-LEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           +D S+ SL  +P EIFTF + LEE++L+ NQIEE+P+++   +++  L L  N+L +L  
Sbjct: 27  LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86

Query: 89  ALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVI--FKNLHHLEL 146
           ++  L +L  LD+S N I      + +     + L + +  +  I  +   F  L +L  
Sbjct: 87  SIANLINLRELDVSKNGIQEFPENIKN----CKVLTIVEASVNPISKLPDGFSQLLNLTQ 142

Query: 147 LGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEE 206
           L L    L+ LP      TKL+ + L+ NQ ++ P+ +  L  LE +DL  N+   +PE 
Sbjct: 143 LYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV 202

Query: 207 IGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSG 266
           +  L+GL++F+M +N L  +P  +    QL+ LD+S N +  + +  +    + ++ LS 
Sbjct: 203 LEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSS 262

Query: 267 NRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALK 326
           N L+++P  I    ++  L +    L  L  S   L+++  LD S N +   P  I  L 
Sbjct: 263 NSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT 322

Query: 327 NLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFK 386
           NL     D N + QLP E+GS   + +L L  N+  + PEE   +  ++KL +      +
Sbjct: 323 NLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE---MGDMQKLKVINLSDNR 379

Query: 387 LTYVPEHIRKLQSLKELYIENN 408
           L  +P    KLQ L  +++ +N
Sbjct: 380 LKNLPFSFTKLQQLTAMWLSDN 401



 Score =  158 bits (400), Expect = 1e-38
 Identities = 108/362 (29%), Positives = 182/362 (50%), Gaps = 7/362 (1%)

Query: 154 LKCLPKEIVNQTK-LREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTG 212
           L+ +PKEI    K L E+YL  NQ E  P++L    +L  + L +N +  +P  I +L  
Sbjct: 34  LEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLIN 93

Query: 213 LQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKV 272
           L++  ++ N +   P ++  C  L++++ S N +  +P  F++L  +T++ L+   LE +
Sbjct: 94  LRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFL 153

Query: 273 PRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLG 332
           P    R T L +L L    L  L  +   L  L  LDL  N     P  +  L  L+   
Sbjct: 154 PANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFW 213

Query: 333 LDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPE 392
           +D N++  +P  +GSL +L  L ++ N      E + +  +L+ L +  +    L  +PE
Sbjct: 214 MDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNS---LQQLPE 270

Query: 393 HIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLE 452
            I  L+++  L I+ N L YLP S+G + ++E LDC  N ++ LP +I Q   L+    +
Sbjct: 271 TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAAD 330

Query: 453 DNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRNRNI--MATK 510
            N L  LP  + S  N+ VL L  N +E  P+E+  +  +     L +NR +N+    TK
Sbjct: 331 HNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEM-GDMQKLKVINLSDNRLKNLPFSFTK 389

Query: 511 IQ 512
           +Q
Sbjct: 390 LQ 391



 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 55/225 (24%), Positives = 110/225 (48%), Gaps = 26/225 (11%)

Query: 29  FIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           ++D S  ++  +   I T   L+++ L +N ++++P+ I  LKNI  L +D+N L  L  
Sbjct: 234 YLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPD 293

Query: 89  ALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLG 148
           ++G L S+E LD S+N + +    + S +  L  LR +  D                   
Sbjct: 294 SIGGLISVEELDCSFNEVEA----LPSSIGQLTNLRTFAAD------------------- 330

Query: 149 LTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIG 208
              N+L+ LP EI +   +  ++L  N+ E  P+E+  +  L++I+L +N++  +P    
Sbjct: 331 --HNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFT 388

Query: 209 HLTGLQKFYMASN-NLPVLPASLCQCSQLSVLDLSHNLLHSIPKS 252
            L  L   +++ N + P++P      S+   + L++ +    P++
Sbjct: 389 KLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRT 433


>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
          Length = 524

 Score =  169 bits (429), Expect = 5e-42
 Identities = 121/382 (31%), Positives = 183/382 (47%), Gaps = 5/382 (1%)

Query: 96  LESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLK 155
           +ES+D  +  +      +  +  +L EL L    L+E+P   F+ L  L  LGL+ N ++
Sbjct: 14  VESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQ-LVKLRKLGLSDNEIQ 72

Query: 156 CLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQK 215
            LP EI N  +L E+ + RN+    P+ +     L++ D   N +  +PE    L  L  
Sbjct: 73  RLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTC 132

Query: 216 FYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRL 275
             +   +L  LP ++     L+ L+L  NLL  +P S  +LR++ E+ L  N +  +P  
Sbjct: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPES 192

Query: 276 ICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDD 335
           I     L  L+L    L  L      L NL  LD+S+N L   P +I  L +L  L +  
Sbjct: 193 IGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQ 252

Query: 336 NKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIR 395
           N +  +P  +G L KL IL +  N     PE V    SL +L + ++Q   L  +P+ I 
Sbjct: 253 NLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQ---LLTLPKSIG 309

Query: 396 KLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNL 455
           KL+ L  L  + N L  LP  +G   +L V   R N L ++P  + QA  L  L +  N 
Sbjct: 310 KLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNR 369

Query: 456 LTHLPENLDSLVNLKVLTLMDN 477
           L HLP +L +L  LK L L DN
Sbjct: 370 LLHLPLSLTAL-KLKALWLSDN 390



 Score =  161 bits (408), Expect = 1e-39
 Identities = 118/387 (30%), Positives = 184/387 (47%), Gaps = 25/387 (6%)

Query: 143 HLELLGLTGNHLKCLPKEIVNQTK-LREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIG 201
           H+E +      L  +P+EI    + L E+ L  NQ    P++   L  L  + L +N+I 
Sbjct: 13  HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQ 72

Query: 202 AIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTE 261
            +P EI +   L +  ++ N +P +P S+  C  L V D S N L  +P+SF EL+ +T 
Sbjct: 73  RLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTC 132

Query: 262 IGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQ 321
           + ++   L+ +P  I    +L  L L    L  L  S   L  L  LDL  N +++ P  
Sbjct: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPES 192

Query: 322 ICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQ 381
           I AL +L+ L LD N++ +LP E+G+L  L  L ++ N     PEE+  L SL  L I Q
Sbjct: 193 IGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQ 252

Query: 382 ---------------------DQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSM 420
                                DQ  +LT +PE + + +SL EL +  N L  LP S+G +
Sbjct: 253 NLLETIPDGIGKLKKLSILKVDQN-RLTQLPEAVGECESLTELVLTENQLLTLPKSIGKL 311

Query: 421 PNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPME 480
             L  L+   N L  LP  I    +L    + DN LT +P  +     L VL +  N + 
Sbjct: 312 KKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLL 371

Query: 481 EPPKEVCAEGNEAIWKYLKENRNRNIM 507
             P  + A   +A+W  L +N+++ ++
Sbjct: 372 HLPLSLTALKLKALW--LSDNQSQPLL 396



 Score =  153 bits (387), Expect = 4e-37
 Identities = 127/418 (30%), Positives = 193/418 (46%), Gaps = 13/418 (3%)

Query: 30  IDASNQSLTAIPLEIFTFTE-LEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           ID  + SL  +P EI+ +   LEE+ L+ NQ+ E+P++  +L  +R L L  N ++ L P
Sbjct: 17  IDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPP 76

Query: 89  ALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLG 148
            +     L  LD+S N I       +SF  AL+        L  +P   F  L +L  L 
Sbjct: 77  EIANFMQLVELDVSRNEI-PEIPESISFCKALQVADFSGNPLTRLP-ESFPELQNLTCLS 134

Query: 149 LTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIG 208
           +    L+ LP+ I N   L  + L+ N     P  L  L  LE +DL  N+I  +PE IG
Sbjct: 135 VNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIG 194

Query: 209 HLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNR 268
            L  L+  ++  N L  LP  +     L  LD+S N L  +P+  + L  +T++ +S N 
Sbjct: 195 ALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNL 254

Query: 269 LEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNL 328
           LE +P  I +   L +L +    L +L  +     +L  L L++N L   P  I  LK L
Sbjct: 255 LETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKL 314

Query: 329 EVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLT 388
             L  D NK+  LP E+G    L +  +  N     P EV     L  L +    G +L 
Sbjct: 315 SNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVA---GNRLL 371

Query: 389 YVPEHIRKLQSLKELYIENNHLEYL---PVSLGSMPNLEVLDCRHNLLKQLP-DAICQ 442
           ++P  +  L+ LK L++ +N  + L             ++L C   LL QLP +  CQ
Sbjct: 372 HLPLSLTALK-LKALWLSDNQSQPLLTFQTDTDYTTGEKILTC--VLLPQLPSEPTCQ 426


>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
           [Homo sapiens]
          Length = 1052

 Score =  166 bits (419), Expect = 7e-41
 Identities = 119/369 (32%), Positives = 186/369 (50%), Gaps = 29/369 (7%)

Query: 135 VVIFKNLHHLELLGLTGNHLKCLPKEIVNQT-KLREIYLKRNQFEVFPQELCVL-YTLEI 192
           +V+  NL  +E L L  N L+ +P+ + +    LR + L+RN+F   P  +  L + L  
Sbjct: 56  LVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTE 115

Query: 193 IDLDENKIGAIPEEI-GHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPK 251
           +D+  N++ A+  E+   L  L+K  ++ N LP LPA L   + L  LD+S N L  +P 
Sbjct: 116 LDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPD 175

Query: 252 SFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLS 311
           S + L ++  + +  N+L   PR + +  +L  L + +  L  L      L  L+ L LS
Sbjct: 176 SLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLS 235

Query: 312 QNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSL 371
              L   P   C L +LE L LD+N +  LP++   L +LK+L L+ N F  FP  +L L
Sbjct: 236 GAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPL 295

Query: 372 ASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHN 431
           A LE+LY+ ++Q   LT VP  I  L  L  L+++NN + YLP                 
Sbjct: 296 AGLEELYLSRNQ---LTSVPSLISGLGRLLTLWLDNNRIRYLP----------------- 335

Query: 432 LLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGN 491
                 D+I +   L+EL L+ N +  LP++   L  + +  + DNP+ +PP EVC +G 
Sbjct: 336 ------DSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGI 389

Query: 492 EAIWKYLKE 500
             I  Y KE
Sbjct: 390 PYIAAYQKE 398



 Score =  155 bits (393), Expect = 7e-38
 Identities = 104/322 (32%), Positives = 163/322 (50%), Gaps = 3/322 (0%)

Query: 49  ELEEVHLENNQIEEIPQEI-QRLKNIRVLYLDKNNLRSLCPALGLLSS-LESLDLSYNPI 106
           ++E ++L NN +EE+P+ +   L ++RVL L +N    L PA+  L   L  LD+S+N +
Sbjct: 64  DIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRL 123

Query: 107 FSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTK 166
            +    VVS L  LR+L L    L  +P  +   L HLE L ++ N L  LP  +   ++
Sbjct: 124 TALGAEVVSALRELRKLNLSHNQLPALPAQLGA-LAHLEELDVSFNRLAHLPDSLSCLSR 182

Query: 167 LREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVL 226
           LR + +  NQ   FP++L  L  LE +D+  N++  +PE+I  L  L+  +++   L  L
Sbjct: 183 LRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTL 242

Query: 227 PASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLY 286
           PA  C+ + L  L L +N L ++P  F+ L+++  + LS N  E+ P  +     L  LY
Sbjct: 243 PAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELY 302

Query: 287 LGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELG 346
           L    L  +      L  L  L L  N + + P  I  L  LE L L  N+I  LP   G
Sbjct: 303 LSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFG 362

Query: 347 SLSKLKILGLTGNEFLSFPEEV 368
            LS++ +  +  N  +  P EV
Sbjct: 363 QLSRVGLWKIKDNPLIQPPYEV 384



 Score =  147 bits (372), Expect = 2e-35
 Identities = 99/319 (31%), Positives = 155/319 (48%), Gaps = 4/319 (1%)

Query: 93  LSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGN 152
           L  +E+L+L  N +      + S L +LR L L +     +P  + +  HHL  L ++ N
Sbjct: 62  LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121

Query: 153 HLKCLPKEIVNQTK-LREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLT 211
            L  L  E+V+  + LR++ L  NQ    P +L  L  LE +D+  N++  +P+ +  L+
Sbjct: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLS 181

Query: 212 GLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEK 271
            L+   +  N L   P  L Q   L  LD+S N L  +P+  + LR +  + LSG  L  
Sbjct: 182 RLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGT 241

Query: 272 VPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVL 331
           +P   C   SL  L L N GL  L   F CL  L+ L+LS N     P  +  L  LE L
Sbjct: 242 LPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEEL 301

Query: 332 GLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVP 391
            L  N++  +PS +  L +L  L L  N     P+ ++ L  LE+L +   QG ++  +P
Sbjct: 302 YLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVL---QGNQIAVLP 358

Query: 392 EHIRKLQSLKELYIENNHL 410
           +H  +L  +    I++N L
Sbjct: 359 DHFGQLSRVGLWKIKDNPL 377



 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 73/248 (29%), Positives = 120/248 (48%), Gaps = 2/248 (0%)

Query: 30  IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
           ++ S+  L A+P ++     LEE+ +  N++  +P  +  L  +R L +D N L +    
Sbjct: 140 LNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQ 199

Query: 90  LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
           L  L +LE LD+S N +       +S L AL+ L L   +L  +P   F  L  LE L L
Sbjct: 200 LLQLVALEELDVSSNRL-RGLPEDISALRALKILWLSGAELGTLPAG-FCELASLESLML 257

Query: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGH 209
             N L+ LP +     +L+ + L  N FE FP  L  L  LE + L  N++ ++P  I  
Sbjct: 258 DNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISG 317

Query: 210 LTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRL 269
           L  L   ++ +N +  LP S+ + + L  L L  N +  +P  F +L ++    +  N L
Sbjct: 318 LGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPL 377

Query: 270 EKVPRLIC 277
            + P  +C
Sbjct: 378 IQPPYEVC 385



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 25/81 (30%), Positives = 39/81 (48%)

Query: 26  RTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRS 85
           R   ++ S+      P  +     LEE++L  NQ+  +P  I  L  +  L+LD N +R 
Sbjct: 274 RLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRY 333

Query: 86  LCPALGLLSSLESLDLSYNPI 106
           L  ++  L+ LE L L  N I
Sbjct: 334 LPDSIVELTGLEELVLQGNQI 354


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score =  160 bits (405), Expect = 3e-39
 Identities = 118/382 (30%), Positives = 179/382 (46%), Gaps = 5/382 (1%)

Query: 96  LESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLK 155
           +ES+D  +  + +    +  +  +L EL L    L+E+P   F+ L +L  LGL+ N ++
Sbjct: 14  VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFR-LLNLRKLGLSDNEIQ 72

Query: 156 CLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQK 215
            LP E+ N  +L E+ + RN     P+ +     LEI D   N +  +P+    L  L  
Sbjct: 73  RLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAH 132

Query: 216 FYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRL 275
             +   +L  LP  +   + L  L+L  NLL S+P S + L K+ ++ L GN LE +P  
Sbjct: 133 LALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDT 192

Query: 276 ICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDD 335
           +    +L  L+L    L  L      L  L  LD+S+N L   P ++  L  L  L L  
Sbjct: 193 LGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQ 252

Query: 336 NKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIR 395
           N + +LP  +G L +L IL +  N      E +    +L +L + ++    L  +P  + 
Sbjct: 253 NLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTEN---LLMALPRSLG 309

Query: 396 KLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNL 455
           KL  L  L ++ NHLE LP  +G    L VL  R N L  LP  +     L  L +  N 
Sbjct: 310 KLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNR 369

Query: 456 LTHLPENLDSLVNLKVLTLMDN 477
           L  LP  L  L NLK L L +N
Sbjct: 370 LQSLPFALTHL-NLKALWLAEN 390



 Score =  155 bits (392), Expect = 9e-38
 Identities = 122/377 (32%), Positives = 184/377 (48%), Gaps = 25/377 (6%)

Query: 30  IDASNQSLTAIPLEIFTFTE-LEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           +D  + SL A+P EI+ ++  LEE+ L+ NQ+ E+P+   RL N+R L L  N ++ L P
Sbjct: 17  VDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPP 76

Query: 89  ALGLLSSLESLDLSYNPI--------FSSSLVVVSF--------------LHALRELRLY 126
            +     L  LD+S N I        F  +L +  F              L +L  L L 
Sbjct: 77  EVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALN 136

Query: 127 QTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCV 186
              L+ +P  +  NL +L  L L  N LK LP  +    KL ++ L  N  EV P  L  
Sbjct: 137 DVSLQALPGDV-GNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA 195

Query: 187 LYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLL 246
           L  L  + LD N++ A+P E+G+L  L    ++ N L  LPA L     L+ L LS NLL
Sbjct: 196 LPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL 255

Query: 247 HSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLR 306
             +P    +L++++ + +  NRL +V   I    +L  L L    L  L  S   L  L 
Sbjct: 256 RRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLT 315

Query: 307 FLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPE 366
            L++ +NHL   P +I     L VL L DN++  LP EL   ++L +L + GN   S P 
Sbjct: 316 NLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPF 375

Query: 367 EVLSLASLEKLYIGQDQ 383
            +  L +L+ L++ ++Q
Sbjct: 376 ALTHL-NLKALWLAENQ 391



 Score =  153 bits (386), Expect = 5e-37
 Identities = 111/358 (31%), Positives = 174/358 (48%), Gaps = 6/358 (1%)

Query: 130 LKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTK-LREIYLKRNQFEVFPQELCVLY 188
           LK IP  +++   H+E +      L+ +P+EI   ++ L E+ L  NQ    P+    L 
Sbjct: 2   LKCIP--LWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLL 59

Query: 189 TLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHS 248
            L  + L +N+I  +P E+ +   L +  ++ N++P +P S+  C  L + D S N L  
Sbjct: 60  NLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR 119

Query: 249 IPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFL 308
           +P  F +LR +  + L+   L+ +P  +    +L  L L    L  L  S   LV L  L
Sbjct: 120 LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQL 179

Query: 309 DLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEV 368
           DL  N L   P  + AL NL  L LD N++  LP ELG+L +L  L ++ N     P E+
Sbjct: 180 DLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAEL 239

Query: 369 LSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDC 428
             L  L  L + Q+    L  +P+ I +L+ L  L ++ N L  +  ++G   NL  L  
Sbjct: 240 GGLVLLTDLLLSQN---LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELIL 296

Query: 429 RHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486
             NLL  LP ++ +   L  L ++ N L  LP  +   V L VL+L DN +   P E+
Sbjct: 297 TENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPEL 354



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 53/219 (24%), Positives = 84/219 (38%), Gaps = 49/219 (22%)

Query: 26  RTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRS 85
           R   +D S   L  +P E+     L ++ L  N +  +P  I +LK + +L +D+N L  
Sbjct: 221 RLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280

Query: 86  LCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLE 145
           +  A+G   +L  L L                                            
Sbjct: 281 VTEAIGDCENLSELIL-------------------------------------------- 296

Query: 146 LLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPE 205
               T N L  LP+ +   TKL  + + RN  E  P E+     L ++ L +N++  +P 
Sbjct: 297 ----TENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPP 352

Query: 206 EIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHN 244
           E+ H T L    +A N L  LP +L   + L  L L+ N
Sbjct: 353 ELAHTTELHVLDVAGNRLQSLPFALTHLN-LKALWLAEN 390


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score =  160 bits (405), Expect = 3e-39
 Identities = 118/382 (30%), Positives = 179/382 (46%), Gaps = 5/382 (1%)

Query: 96  LESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLK 155
           +ES+D  +  + +    +  +  +L EL L    L+E+P   F+ L +L  LGL+ N ++
Sbjct: 14  VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFR-LLNLRKLGLSDNEIQ 72

Query: 156 CLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQK 215
            LP E+ N  +L E+ + RN     P+ +     LEI D   N +  +P+    L  L  
Sbjct: 73  RLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAH 132

Query: 216 FYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRL 275
             +   +L  LP  +   + L  L+L  NLL S+P S + L K+ ++ L GN LE +P  
Sbjct: 133 LALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDT 192

Query: 276 ICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDD 335
           +    +L  L+L    L  L      L  L  LD+S+N L   P ++  L  L  L L  
Sbjct: 193 LGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQ 252

Query: 336 NKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIR 395
           N + +LP  +G L +L IL +  N      E +    +L +L + ++    L  +P  + 
Sbjct: 253 NLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTEN---LLMALPRSLG 309

Query: 396 KLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNL 455
           KL  L  L ++ NHLE LP  +G    L VL  R N L  LP  +     L  L +  N 
Sbjct: 310 KLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNR 369

Query: 456 LTHLPENLDSLVNLKVLTLMDN 477
           L  LP  L  L NLK L L +N
Sbjct: 370 LQSLPFALTHL-NLKALWLAEN 390



 Score =  155 bits (392), Expect = 9e-38
 Identities = 122/377 (32%), Positives = 184/377 (48%), Gaps = 25/377 (6%)

Query: 30  IDASNQSLTAIPLEIFTFTE-LEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           +D  + SL A+P EI+ ++  LEE+ L+ NQ+ E+P+   RL N+R L L  N ++ L P
Sbjct: 17  VDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPP 76

Query: 89  ALGLLSSLESLDLSYNPI--------FSSSLVVVSF--------------LHALRELRLY 126
            +     L  LD+S N I        F  +L +  F              L +L  L L 
Sbjct: 77  EVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALN 136

Query: 127 QTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCV 186
              L+ +P  +  NL +L  L L  N LK LP  +    KL ++ L  N  EV P  L  
Sbjct: 137 DVSLQALPGDV-GNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA 195

Query: 187 LYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLL 246
           L  L  + LD N++ A+P E+G+L  L    ++ N L  LPA L     L+ L LS NLL
Sbjct: 196 LPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL 255

Query: 247 HSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLR 306
             +P    +L++++ + +  NRL +V   I    +L  L L    L  L  S   L  L 
Sbjct: 256 RRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLT 315

Query: 307 FLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPE 366
            L++ +NHL   P +I     L VL L DN++  LP EL   ++L +L + GN   S P 
Sbjct: 316 NLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPF 375

Query: 367 EVLSLASLEKLYIGQDQ 383
            +  L +L+ L++ ++Q
Sbjct: 376 ALTHL-NLKALWLAENQ 391



 Score =  153 bits (386), Expect = 5e-37
 Identities = 111/358 (31%), Positives = 174/358 (48%), Gaps = 6/358 (1%)

Query: 130 LKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTK-LREIYLKRNQFEVFPQELCVLY 188
           LK IP  +++   H+E +      L+ +P+EI   ++ L E+ L  NQ    P+    L 
Sbjct: 2   LKCIP--LWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLL 59

Query: 189 TLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHS 248
            L  + L +N+I  +P E+ +   L +  ++ N++P +P S+  C  L + D S N L  
Sbjct: 60  NLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR 119

Query: 249 IPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFL 308
           +P  F +LR +  + L+   L+ +P  +    +L  L L    L  L  S   LV L  L
Sbjct: 120 LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQL 179

Query: 309 DLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEV 368
           DL  N L   P  + AL NL  L LD N++  LP ELG+L +L  L ++ N     P E+
Sbjct: 180 DLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAEL 239

Query: 369 LSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDC 428
             L  L  L + Q+    L  +P+ I +L+ L  L ++ N L  +  ++G   NL  L  
Sbjct: 240 GGLVLLTDLLLSQN---LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELIL 296

Query: 429 RHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486
             NLL  LP ++ +   L  L ++ N L  LP  +   V L VL+L DN +   P E+
Sbjct: 297 TENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPEL 354



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 53/219 (24%), Positives = 84/219 (38%), Gaps = 49/219 (22%)

Query: 26  RTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRS 85
           R   +D S   L  +P E+     L ++ L  N +  +P  I +LK + +L +D+N L  
Sbjct: 221 RLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280

Query: 86  LCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLE 145
           +  A+G   +L  L L                                            
Sbjct: 281 VTEAIGDCENLSELIL-------------------------------------------- 296

Query: 146 LLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPE 205
               T N L  LP+ +   TKL  + + RN  E  P E+     L ++ L +N++  +P 
Sbjct: 297 ----TENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPP 352

Query: 206 EIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHN 244
           E+ H T L    +A N L  LP +L   + L  L L+ N
Sbjct: 353 ELAHTTELHVLDVAGNRLQSLPFALTHLN-LKALWLAEN 390


>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
          Length = 602

 Score =  152 bits (384), Expect = 8e-37
 Identities = 138/530 (26%), Positives = 236/530 (44%), Gaps = 52/530 (9%)

Query: 6   KSVEHSPKIHQRNDPQHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQ 65
           K +  + K+    D   +      +D  +  LT++P  I     L+++++ +N+++ +P+
Sbjct: 86  KLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPE 145

Query: 66  EIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSF--LHALREL 123
           EI  L+N++ LYL  N L  +      LS+LE LDLS N +   + V  SF  L +L  L
Sbjct: 146 EITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHL---TTVPASFSSLSSLVRL 202

Query: 124 RLYQTDLKEIPVVI--FKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFP 181
            L   +LK +P  I   K L HL+      N L+ +P E+     L  +YL+RN+    P
Sbjct: 203 NLSSNELKSLPAEINRMKRLKHLD---CNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259

Query: 182 Q-ELCVLYTLEIIDLDENKIGAI-PEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVL 239
           +   C L  L+ + + EN+I  +  E + HL  +    +  N L  +P  +     L  L
Sbjct: 260 EFPSCSL--LKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERL 317

Query: 240 DLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPR-LICRWTSLHLLYLGNTGLHRLRGS 298
           DLS+N + S+P S   L  +  + L GN L  + R +I + T   L YL +         
Sbjct: 318 DLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQ 376

Query: 299 FRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKI---LG 355
                       S++ ++     I A+  L++L   D +   +P E+    K  I   + 
Sbjct: 377 SESATETAMTLPSESRVN-----IHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSIN 431

Query: 356 LTGNEFLSFPEEVLSLASLEKLYIGQDQGF-KLTYVPEHIRKLQSLKELYIENNHLEYLP 414
            + N+    P+    +  L+++    D  F KL+++   +  LQ L  L + NN L  LP
Sbjct: 432 FSKNQLCEIPKR---MVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLP 488

Query: 415 VSLGSMPNLEVLDCRHNLLKQLPDAICQ------------------------AQALKELR 450
             + S+  L+ ++   N  K LP+ + +                         + L  L 
Sbjct: 489 EEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLD 548

Query: 451 LEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKE 500
           L++N L  +P  L + VNL+ L L  NP   P   +  +G  AI +YL++
Sbjct: 549 LQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILMKGTAAILEYLRD 598



 Score =  150 bits (380), Expect = 2e-36
 Identities = 99/290 (34%), Positives = 156/290 (53%), Gaps = 6/290 (2%)

Query: 211 TGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLE 270
           T L K  +++N L  L   L     L+VLD+  N L S+P +  EL  + ++ +S N+L+
Sbjct: 82  TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141

Query: 271 KVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEV 330
            +P  I    +L  LYL +  L  +   F  L NL  LDLS NHL   P    +L +L  
Sbjct: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201

Query: 331 LGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYV 390
           L L  N++  LP+E+  + +LK L    N   + P E+  + SLE LY+ ++   KL ++
Sbjct: 202 LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRN---KLRFL 258

Query: 391 PEHIRKLQSLKELYIENNHLEYLPVS-LGSMPNLEVLDCRHNLLKQLPDAICQAQALKEL 449
           PE       LKEL++  N +E L    L  + ++ VLD R N LK +PD I   ++L+ L
Sbjct: 259 PE-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERL 317

Query: 450 RLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLK 499
            L +N ++ LP +L +L +LK L L  NP+    +E+ ++G + + KYL+
Sbjct: 318 DLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLR 366



 Score =  131 bits (329), Expect = 2e-30
 Identities = 126/478 (26%), Positives = 208/478 (43%), Gaps = 50/478 (10%)

Query: 52  EVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLR-SLCPALGLLSSLESLDLSYNPIFSSS 110
           +++L    + E+PQ + R+ N+ +      NL           + L  L +S N +  S 
Sbjct: 40  QLNLSGRNLSEVPQCVWRI-NVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKL-QSL 97

Query: 111 LVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREI 170
              +  L AL  L ++   L  +P  I + L +L+ L ++ N LK LP+EI N   L+ +
Sbjct: 98  TDDLRLLPALTVLDIHDNQLTSLPSAI-RELENLQKLNVSHNKLKILPEEITNLRNLKCL 156

Query: 171 YLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASL 230
           YL+ N+     +    L  LE +DL  N +  +P     L+ L +  ++SN L  LPA +
Sbjct: 157 YLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEI 216

Query: 231 CQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNT 290
            +  +L  LD + NLL +IP   A +  +  + L  N+L  +P      + L  L++G  
Sbjct: 217 NRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLKELHVGEN 275

Query: 291 GLHRLRGS-FRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLS 349
            +  L     + L ++  LDL  N L   P +I  L++LE L L +N I  LP  LG+L 
Sbjct: 276 QIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL- 334

Query: 350 KLKILGLTGNEFLSFPEEVLSLASLEKL-YIG---QDQG--------------------- 384
            LK L L GN   +   E++S  + E L Y+    +D G                     
Sbjct: 335 HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVN 394

Query: 385 --------------FKLTYVPEHI---RKLQSLKELYIENNHLEYLPVSLGSMPNL-EVL 426
                          + T +P+ +    K   +  +    N L  +P  +  +  +   +
Sbjct: 395 IHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDV 454

Query: 427 DCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPK 484
           D   N L  +   +C  Q L  L L +N L  LPE ++SLV L+ + L  N  +  P+
Sbjct: 455 DLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPE 512



 Score =  107 bits (267), Expect = 3e-23
 Identities = 87/283 (30%), Positives = 128/283 (45%), Gaps = 28/283 (9%)

Query: 248 SIPKSFAEL-RKMTEIGLSGNRLEKVPRLIC--------------------RW---TSLH 283
           S+P+   +  RK  ++ LSG  L +VP+ +                     RW   T L 
Sbjct: 26  SVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLT 85

Query: 284 LLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPS 343
            L + N  L  L    R L  L  LD+  N L   P  I  L+NL+ L +  NK+  LP 
Sbjct: 86  KLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPE 145

Query: 344 ELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKEL 403
           E+ +L  LK L L  NE     E    L++LE L +  +    LT VP     L SL  L
Sbjct: 146 EITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNH---LTTVPASFSSLSSLVRL 202

Query: 404 YIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENL 463
            + +N L+ LP  +  M  L+ LDC  NLL+ +P  +   ++L+ L L  N L  LPE  
Sbjct: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-F 261

Query: 464 DSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRNRNI 506
            S   LK L + +N +E    E     N  +   L++N+ +++
Sbjct: 262 PSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSV 304



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 40/171 (23%), Positives = 72/171 (42%), Gaps = 24/171 (14%)

Query: 30  IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
           +D S   L+ I LE+    +L  + L NN +  +P+E++ L  ++ + L  N  + L   
Sbjct: 454 VDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEV 513

Query: 90  LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
           L  + +LE++ +S N + S                        +     K + +L  L L
Sbjct: 514 LYRIFTLETILISNNQVGS------------------------VDPQKMKMMENLTTLDL 549

Query: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKI 200
             N L  +P E+ N   LR + L  N F V    + +  T  I++   ++I
Sbjct: 550 QNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILMKGTAAILEYLRDRI 600


>gi|4503743 flightless I homolog [Homo sapiens]
          Length = 1269

 Score =  147 bits (370), Expect = 3e-35
 Identities = 115/367 (31%), Positives = 178/367 (48%), Gaps = 31/367 (8%)

Query: 149 LTGNHLK--CLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEE 206
           L+GN  K    P+ +   T LR + L R      P+EL  L  LE + +  N +  +  E
Sbjct: 15  LSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGE 74

Query: 207 IGHLTGLQKFYMASNNLPV--LPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGL 264
           +  L  L+     +N+L    +P  + +   LSVLDLSHN L   P+     + M  + L
Sbjct: 75  LSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNL 134

Query: 265 SGNRLEKVP-RLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPL-QI 322
           S N ++ +P +L    T L  L L    L  L    R LV+L+ L L+ N L H  L Q+
Sbjct: 135 SHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQL 194

Query: 323 CALKNLEVLGLDDNKIGQ--LPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIG 380
            A+  L+ L L   +  Q  LP+ L  LS L  + L+ N+    PE + +L SL +L + 
Sbjct: 195 PAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLS 254

Query: 381 QDQ--------------------GFKLTYVPEHIRKLQSLKELYIENNHLEY--LPVSLG 418
            +Q                      +LT +P  I KL  LK+LY+ +N L++  LP  +G
Sbjct: 255 SNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIG 314

Query: 419 SMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNP 478
            + NLE     +N L+ +P+++C+   L++L L  N L  LPE +  L  ++VL + +NP
Sbjct: 315 KLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENP 374

Query: 479 -MEEPPK 484
            +  PPK
Sbjct: 375 NLVMPPK 381



 Score =  122 bits (306), Expect = 9e-28
 Identities = 110/399 (27%), Positives = 174/399 (43%), Gaps = 59/399 (14%)

Query: 41  PLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLD 100
           P  +   T L  + L    +  +P+E+  L+ +  L +  NNL +L   L  L SL ++ 
Sbjct: 26  PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85

Query: 101 LSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKE 160
              N + +S                       +P  IFK L  L +L L+ N L   P+E
Sbjct: 86  ARANSLKNSG----------------------VPDDIFK-LDDLSVLDLSHNQLTECPRE 122

Query: 161 IVNQTKLREIYLKRNQFEVFPQELCV-LYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMA 219
           + N   +  + L  N  +  P +L + L  L  +DL EN++ ++P ++  L  LQ   + 
Sbjct: 123 LENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLN 182

Query: 220 SNNLPVLPASLCQCSQLSVLDLSH-----NLLHSIPKSFAELRKMTEIGLSGNRLEKVPR 274
            N  P+L A L Q   ++ L   H         ++P S   L  + ++ LS N L +VP 
Sbjct: 183 GN--PLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE 240

Query: 275 LICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLD 334
             C +T                     L +LR L+LS N +    L I    ++E L L 
Sbjct: 241 --CLYT---------------------LPSLRRLNLSSNQITELSLCIDQWVHVETLNLS 277

Query: 335 DNKIGQLPSELGSLSKLKILGLTGN--EFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPE 392
            N++  LPS +  LSKLK L L  N  +F   P  +  L +LE+     +    L  VPE
Sbjct: 278 RNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANN---NLELVPE 334

Query: 393 HIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHN 431
            + +   L++L +  NHL  LP ++  +  +EVLD R N
Sbjct: 335 SLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373



 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 81/293 (27%), Positives = 133/293 (45%), Gaps = 52/293 (17%)

Query: 26  RTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVL--------- 76
           R     A++   + +P +IF   +L  + L +NQ+ E P+E++  KN+ VL         
Sbjct: 82  RAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDT 141

Query: 77  -------------YLD--KNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALR 121
                        YLD  +N L SL P +  L  L++L L+ NP+  + L  +  + AL+
Sbjct: 142 IPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQ 201

Query: 122 ELRLYQT-------------------------DLKEIPVVIFKNLHHLELLGLTGNHLKC 156
            L L  T                         DL  +P  ++  L  L  L L+ N +  
Sbjct: 202 TLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLY-TLPSLRRLNLSSNQITE 260

Query: 157 LPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIG--AIPEEIGHLTGLQ 214
           L   I     +  + L RNQ    P  +C L  L+ + L+ NK+    +P  IG LT L+
Sbjct: 261 LSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLE 320

Query: 215 KFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGN 267
           +F  A+NNL ++P SLC+C +L  L L+ N L ++P++   L ++  + +  N
Sbjct: 321 EFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 2/153 (1%)

Query: 30  IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
           +D S   LT +P  ++T   L  ++L +NQI E+   I +  ++  L L +N L SL  A
Sbjct: 228 VDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSA 287

Query: 90  LGLLSSLESLDLSYNPI-FSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLG 148
           +  LS L+ L L+ N + F      +  L  L E      +L+ +P  + +    L  L 
Sbjct: 288 ICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCR-CPKLRKLV 346

Query: 149 LTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFP 181
           L  NHL  LP+ I   T++  + ++ N   V P
Sbjct: 347 LNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 25/80 (31%), Positives = 44/80 (55%)

Query: 26  RTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRS 85
           +  +++++      +P  I   T LEE    NN +E +P+ + R   +R L L+KN+L +
Sbjct: 295 KKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVT 354

Query: 86  LCPALGLLSSLESLDLSYNP 105
           L  A+  L+ +E LD+  NP
Sbjct: 355 LPEAIHFLTEIEVLDVRENP 374


>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
           sapiens]
          Length = 810

 Score =  124 bits (312), Expect = 2e-28
 Identities = 89/263 (33%), Positives = 137/263 (52%), Gaps = 29/263 (11%)

Query: 40  IPLEIFTFTELEEVHL------ENNQIEEIP--QEIQRLKNIRV---------------L 76
           IPL I++   LEE+HL      ENN+   I   +E++RLK +R+               +
Sbjct: 508 IPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGV 567

Query: 77  YLDKNNLRSLCPALGLLSSLESL-DLSYNPIFSSSLVVVSF----LHALRELRLYQTDLK 131
           +L K ++ +    L +L+SL+ + +L+   +    L  +      LH L+E+ L   +LK
Sbjct: 568 HLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLK 627

Query: 132 EIPVVI-FKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTL 190
            I  +I F++LH L  L L  NH+  +P +I N T L  +YL RN+ E  P +L     L
Sbjct: 628 TIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKL 687

Query: 191 EIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIP 250
             +DL  N +  +P +IG L  LQ   + +N +  LP  L QC +L  L L +N+L S+P
Sbjct: 688 RYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLP 747

Query: 251 KSFAELRKMTEIGLSGNRLEKVP 273
               EL  +T+I L GNRLE +P
Sbjct: 748 SRVGELTNLTQIELRGNRLECLP 770



 Score =  110 bits (275), Expect = 3e-24
 Identities = 128/469 (27%), Positives = 193/469 (41%), Gaps = 100/469 (21%)

Query: 37  LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96
           L+ IP  +F   ELE + LE      IP  I +L  ++ L+L     +   PAL  L   
Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRE- 493

Query: 97  ESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKC 156
                                  LR L +  TD+KEIP+ I+ +L  LE L LTGN    
Sbjct: 494 ----------------------NLRALHIKFTDIKEIPLWIY-SLKTLEELHLTGN---- 526

Query: 157 LPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDEN--KIGAIPEEIGHLTGLQ 214
                        +  + N++ V    L  L  L+++ L  N  K+  +  ++G    LQ
Sbjct: 527 -------------LSAENNRYIVI-DGLRELKRLKVLRLKSNLSKLPQVVTDVG--VHLQ 570

Query: 215 KFYMASNNLPVLPA-SLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVP 273
           K  + +    ++   SL + + L+ L+L    L  IP S   L  + EI L  N L+ + 
Sbjct: 571 KLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIE 630

Query: 274 RLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGL 333
            +I                     SF+ L  L  L L  NH+ + P+QI  L NLE L L
Sbjct: 631 EII---------------------SFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYL 669

Query: 334 DDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEH 393
           + NKI ++P++L    KL+ L L+ N                           LT++P  
Sbjct: 670 NRNKIEKIPTQLFYCRKLRYLDLSHNN--------------------------LTFLPAD 703

Query: 394 IRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLED 453
           I  LQ+L+ L I  N +E LP  L     L  L   +N+L+ LP  + +   L ++ L  
Sbjct: 704 IGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRG 763

Query: 454 NLLTHLPENLDS--LVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKE 500
           N L  LP  L    L+    L + ++     P EV     E +W+  KE
Sbjct: 764 NRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV----KERLWRADKE 808



 Score =  101 bits (251), Expect = 2e-21
 Identities = 99/375 (26%), Positives = 173/375 (46%), Gaps = 30/375 (8%)

Query: 118 HALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQF 177
           +A  +L L+   L  IP  +F +L  LE+L L       +P  I   T L+E++L     
Sbjct: 423 NAQDKLELHLFMLSGIPDTVF-DLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAA 481

Query: 178 EVFPQELCVLY-TLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQL 236
           ++    L  L   L  + +    I  IP  I  L  L++ ++  N              L
Sbjct: 482 KIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGN--------------L 527

Query: 237 SVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHL--LYLGNTGLHR 294
           S    + N  + +     EL+++  + L  N L K+P+++     +HL  L + N G   
Sbjct: 528 S----AENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTD-VGVHLQKLSINNEGTKL 581

Query: 295 L-RGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELG--SLSKL 351
           +   S + + NL  L+L +  L   P  I +L NL+ + L DN +  +   +    L +L
Sbjct: 582 IVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRL 641

Query: 352 KILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLE 411
             L L  N     P ++ +L +LE+LY+ ++   K+  +P  +   + L+ L + +N+L 
Sbjct: 642 TCLKLWYNHIAYIPIQIGNLTNLERLYLNRN---KIEKIPTQLFYCRKLRYLDLSHNNLT 698

Query: 412 YLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKV 471
           +LP  +G + NL+ L    N ++ LP  + Q + L+ L L +N+L  LP  +  L NL  
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758

Query: 472 LTLMDNPMEEPPKEV 486
           + L  N +E  P E+
Sbjct: 759 IELRGNRLECLPVEL 773



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 24/76 (31%), Positives = 46/76 (60%)

Query: 29  FIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           ++D S+ +LT +P +I     L+ + +  N+IE +P E+ + + +R L+L  N L+SL  
Sbjct: 689 YLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPS 748

Query: 89  ALGLLSSLESLDLSYN 104
            +G L++L  ++L  N
Sbjct: 749 RVGELTNLTQIELRGN 764


>gi|187829877 leucine rich repeat containing 8 family, member A
           [Homo sapiens]
          Length = 810

 Score =  124 bits (312), Expect = 2e-28
 Identities = 89/263 (33%), Positives = 137/263 (52%), Gaps = 29/263 (11%)

Query: 40  IPLEIFTFTELEEVHL------ENNQIEEIP--QEIQRLKNIRV---------------L 76
           IPL I++   LEE+HL      ENN+   I   +E++RLK +R+               +
Sbjct: 508 IPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGV 567

Query: 77  YLDKNNLRSLCPALGLLSSLESL-DLSYNPIFSSSLVVVSF----LHALRELRLYQTDLK 131
           +L K ++ +    L +L+SL+ + +L+   +    L  +      LH L+E+ L   +LK
Sbjct: 568 HLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLK 627

Query: 132 EIPVVI-FKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTL 190
            I  +I F++LH L  L L  NH+  +P +I N T L  +YL RN+ E  P +L     L
Sbjct: 628 TIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKL 687

Query: 191 EIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIP 250
             +DL  N +  +P +IG L  LQ   + +N +  LP  L QC +L  L L +N+L S+P
Sbjct: 688 RYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLP 747

Query: 251 KSFAELRKMTEIGLSGNRLEKVP 273
               EL  +T+I L GNRLE +P
Sbjct: 748 SRVGELTNLTQIELRGNRLECLP 770



 Score =  110 bits (275), Expect = 3e-24
 Identities = 128/469 (27%), Positives = 193/469 (41%), Gaps = 100/469 (21%)

Query: 37  LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96
           L+ IP  +F   ELE + LE      IP  I +L  ++ L+L     +   PAL  L   
Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRE- 493

Query: 97  ESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKC 156
                                  LR L +  TD+KEIP+ I+ +L  LE L LTGN    
Sbjct: 494 ----------------------NLRALHIKFTDIKEIPLWIY-SLKTLEELHLTGN---- 526

Query: 157 LPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDEN--KIGAIPEEIGHLTGLQ 214
                        +  + N++ V    L  L  L+++ L  N  K+  +  ++G    LQ
Sbjct: 527 -------------LSAENNRYIVI-DGLRELKRLKVLRLKSNLSKLPQVVTDVG--VHLQ 570

Query: 215 KFYMASNNLPVLPA-SLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVP 273
           K  + +    ++   SL + + L+ L+L    L  IP S   L  + EI L  N L+ + 
Sbjct: 571 KLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIE 630

Query: 274 RLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGL 333
            +I                     SF+ L  L  L L  NH+ + P+QI  L NLE L L
Sbjct: 631 EII---------------------SFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYL 669

Query: 334 DDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEH 393
           + NKI ++P++L    KL+ L L+ N                           LT++P  
Sbjct: 670 NRNKIEKIPTQLFYCRKLRYLDLSHNN--------------------------LTFLPAD 703

Query: 394 IRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLED 453
           I  LQ+L+ L I  N +E LP  L     L  L   +N+L+ LP  + +   L ++ L  
Sbjct: 704 IGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRG 763

Query: 454 NLLTHLPENLDS--LVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKE 500
           N L  LP  L    L+    L + ++     P EV     E +W+  KE
Sbjct: 764 NRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV----KERLWRADKE 808



 Score =  101 bits (251), Expect = 2e-21
 Identities = 99/375 (26%), Positives = 173/375 (46%), Gaps = 30/375 (8%)

Query: 118 HALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQF 177
           +A  +L L+   L  IP  +F +L  LE+L L       +P  I   T L+E++L     
Sbjct: 423 NAQDKLELHLFMLSGIPDTVF-DLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAA 481

Query: 178 EVFPQELCVLY-TLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQL 236
           ++    L  L   L  + +    I  IP  I  L  L++ ++  N              L
Sbjct: 482 KIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGN--------------L 527

Query: 237 SVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHL--LYLGNTGLHR 294
           S    + N  + +     EL+++  + L  N L K+P+++     +HL  L + N G   
Sbjct: 528 S----AENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTD-VGVHLQKLSINNEGTKL 581

Query: 295 L-RGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELG--SLSKL 351
           +   S + + NL  L+L +  L   P  I +L NL+ + L DN +  +   +    L +L
Sbjct: 582 IVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRL 641

Query: 352 KILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLE 411
             L L  N     P ++ +L +LE+LY+ ++   K+  +P  +   + L+ L + +N+L 
Sbjct: 642 TCLKLWYNHIAYIPIQIGNLTNLERLYLNRN---KIEKIPTQLFYCRKLRYLDLSHNNLT 698

Query: 412 YLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKV 471
           +LP  +G + NL+ L    N ++ LP  + Q + L+ L L +N+L  LP  +  L NL  
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758

Query: 472 LTLMDNPMEEPPKEV 486
           + L  N +E  P E+
Sbjct: 759 IELRGNRLECLPVEL 773



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 24/76 (31%), Positives = 46/76 (60%)

Query: 29  FIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           ++D S+ +LT +P +I     L+ + +  N+IE +P E+ + + +R L+L  N L+SL  
Sbjct: 689 YLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPS 748

Query: 89  ALGLLSSLESLDLSYN 104
            +G L++L  ++L  N
Sbjct: 749 RVGELTNLTQIELRGN 764


>gi|187829871 leucine rich repeat containing 8 family, member A
           [Homo sapiens]
          Length = 810

 Score =  124 bits (312), Expect = 2e-28
 Identities = 89/263 (33%), Positives = 137/263 (52%), Gaps = 29/263 (11%)

Query: 40  IPLEIFTFTELEEVHL------ENNQIEEIP--QEIQRLKNIRV---------------L 76
           IPL I++   LEE+HL      ENN+   I   +E++RLK +R+               +
Sbjct: 508 IPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGV 567

Query: 77  YLDKNNLRSLCPALGLLSSLESL-DLSYNPIFSSSLVVVSF----LHALRELRLYQTDLK 131
           +L K ++ +    L +L+SL+ + +L+   +    L  +      LH L+E+ L   +LK
Sbjct: 568 HLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLK 627

Query: 132 EIPVVI-FKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTL 190
            I  +I F++LH L  L L  NH+  +P +I N T L  +YL RN+ E  P +L     L
Sbjct: 628 TIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKL 687

Query: 191 EIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIP 250
             +DL  N +  +P +IG L  LQ   + +N +  LP  L QC +L  L L +N+L S+P
Sbjct: 688 RYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLP 747

Query: 251 KSFAELRKMTEIGLSGNRLEKVP 273
               EL  +T+I L GNRLE +P
Sbjct: 748 SRVGELTNLTQIELRGNRLECLP 770



 Score =  110 bits (275), Expect = 3e-24
 Identities = 128/469 (27%), Positives = 193/469 (41%), Gaps = 100/469 (21%)

Query: 37  LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96
           L+ IP  +F   ELE + LE      IP  I +L  ++ L+L     +   PAL  L   
Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRE- 493

Query: 97  ESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKC 156
                                  LR L +  TD+KEIP+ I+ +L  LE L LTGN    
Sbjct: 494 ----------------------NLRALHIKFTDIKEIPLWIY-SLKTLEELHLTGN---- 526

Query: 157 LPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDEN--KIGAIPEEIGHLTGLQ 214
                        +  + N++ V    L  L  L+++ L  N  K+  +  ++G    LQ
Sbjct: 527 -------------LSAENNRYIVI-DGLRELKRLKVLRLKSNLSKLPQVVTDVG--VHLQ 570

Query: 215 KFYMASNNLPVLPA-SLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVP 273
           K  + +    ++   SL + + L+ L+L    L  IP S   L  + EI L  N L+ + 
Sbjct: 571 KLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIE 630

Query: 274 RLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGL 333
            +I                     SF+ L  L  L L  NH+ + P+QI  L NLE L L
Sbjct: 631 EII---------------------SFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYL 669

Query: 334 DDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEH 393
           + NKI ++P++L    KL+ L L+ N                           LT++P  
Sbjct: 670 NRNKIEKIPTQLFYCRKLRYLDLSHNN--------------------------LTFLPAD 703

Query: 394 IRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLED 453
           I  LQ+L+ L I  N +E LP  L     L  L   +N+L+ LP  + +   L ++ L  
Sbjct: 704 IGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRG 763

Query: 454 NLLTHLPENLDS--LVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKE 500
           N L  LP  L    L+    L + ++     P EV     E +W+  KE
Sbjct: 764 NRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV----KERLWRADKE 808



 Score =  101 bits (251), Expect = 2e-21
 Identities = 99/375 (26%), Positives = 173/375 (46%), Gaps = 30/375 (8%)

Query: 118 HALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQF 177
           +A  +L L+   L  IP  +F +L  LE+L L       +P  I   T L+E++L     
Sbjct: 423 NAQDKLELHLFMLSGIPDTVF-DLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAA 481

Query: 178 EVFPQELCVLY-TLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQL 236
           ++    L  L   L  + +    I  IP  I  L  L++ ++  N              L
Sbjct: 482 KIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGN--------------L 527

Query: 237 SVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHL--LYLGNTGLHR 294
           S    + N  + +     EL+++  + L  N L K+P+++     +HL  L + N G   
Sbjct: 528 S----AENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTD-VGVHLQKLSINNEGTKL 581

Query: 295 L-RGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELG--SLSKL 351
           +   S + + NL  L+L +  L   P  I +L NL+ + L DN +  +   +    L +L
Sbjct: 582 IVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRL 641

Query: 352 KILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLE 411
             L L  N     P ++ +L +LE+LY+ ++   K+  +P  +   + L+ L + +N+L 
Sbjct: 642 TCLKLWYNHIAYIPIQIGNLTNLERLYLNRN---KIEKIPTQLFYCRKLRYLDLSHNNLT 698

Query: 412 YLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKV 471
           +LP  +G + NL+ L    N ++ LP  + Q + L+ L L +N+L  LP  +  L NL  
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758

Query: 472 LTLMDNPMEEPPKEV 486
           + L  N +E  P E+
Sbjct: 759 IELRGNRLECLPVEL 773



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 24/76 (31%), Positives = 46/76 (60%)

Query: 29  FIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           ++D S+ +LT +P +I     L+ + +  N+IE +P E+ + + +R L+L  N L+SL  
Sbjct: 689 YLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPS 748

Query: 89  ALGLLSSLESLDLSYN 104
            +G L++L  ++L  N
Sbjct: 749 RVGELTNLTQIELRGN 764


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score =  117 bits (294), Expect = 2e-26
 Identities = 140/462 (30%), Positives = 225/462 (48%), Gaps = 28/462 (6%)

Query: 26  RTFFIDASNQSLTAIPLEIF-TFTELEEVHLENNQIEEI-PQEIQRLKNIRVLYLDKNNL 83
           +  ++D +N  L+++P   F   + L  ++L+  Q+  + PQ +  L+N+  L+L++N L
Sbjct: 115 QALWLDGNN--LSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQL 172

Query: 84  RSLCPALGLLS---SLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKN 140
           RSL  ALG  +   +L SL LS N +      +   L +L +L L    L  +P   F+ 
Sbjct: 173 RSL--ALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRG 230

Query: 141 LHHLELLGLTGNHLKCL-PKEIVNQTKLREIYLKRNQFEVFPQELCV-LYTLEIIDLDEN 198
           L  L  L L GN L  L P       +LRE+ L RN        + V L  L+ + LD N
Sbjct: 231 LGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRN 290

Query: 199 KIGAI-PEEIGHLTGLQKFYMASNNLP-VLPASLCQCSQLSVLDLSHNLLHSI-PKSFAE 255
            I A+ P     L  L+   ++ N +  +L  +      L VL LSHN + S+ P++F +
Sbjct: 291 LIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKD 350

Query: 256 LRKMTEIGLSGNRLEKV-PRLICRWTSLHLLYLGNTGLHRLR-GSFRCLVNLRFLDLSQN 313
           L  + E+ L  NR+ ++  R       L +L L +  L  ++ G+F  L N+  ++LS N
Sbjct: 351 LHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 410

Query: 314 HLHHCPLQIC-ALKNLEVLGLDDNKIGQL-PSELGSLSKLKILGLTGNEFLSFPEEVL-S 370
            L + P Q+   L  L  L L+ + +G++ P     LS L+ L L  N  +   E+ L  
Sbjct: 411 CLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWG 470

Query: 371 LASLEKLYIGQDQGFKLTYVPEHI-RKLQSLKELYIENNHLEYLPV-SLGSMPNLEVLDC 428
           LA L +L +  +Q   LT++P  + + L  L+ L +  N L  LP  +LG +     LD 
Sbjct: 471 LAELLELDLTSNQ---LTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDV 527

Query: 429 RHNLLKQLPDA-ICQAQALKELRLEDNLL---THLPENLDSL 466
            HN L+ LP++ +     L+ L L +N L   T  P  L+ L
Sbjct: 528 SHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERL 569


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score =  117 bits (294), Expect = 2e-26
 Identities = 140/462 (30%), Positives = 225/462 (48%), Gaps = 28/462 (6%)

Query: 26  RTFFIDASNQSLTAIPLEIF-TFTELEEVHLENNQIEEI-PQEIQRLKNIRVLYLDKNNL 83
           +  ++D +N  L+++P   F   + L  ++L+  Q+  + PQ +  L+N+  L+L++N L
Sbjct: 77  QALWLDGNN--LSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQL 134

Query: 84  RSLCPALGLLS---SLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKN 140
           RSL  ALG  +   +L SL LS N +      +   L +L +L L    L  +P   F+ 
Sbjct: 135 RSL--ALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRG 192

Query: 141 LHHLELLGLTGNHLKCL-PKEIVNQTKLREIYLKRNQFEVFPQELCV-LYTLEIIDLDEN 198
           L  L  L L GN L  L P       +LRE+ L RN        + V L  L+ + LD N
Sbjct: 193 LGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRN 252

Query: 199 KIGAI-PEEIGHLTGLQKFYMASNNLP-VLPASLCQCSQLSVLDLSHNLLHSI-PKSFAE 255
            I A+ P     L  L+   ++ N +  +L  +      L VL LSHN + S+ P++F +
Sbjct: 253 LIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKD 312

Query: 256 LRKMTEIGLSGNRLEKV-PRLICRWTSLHLLYLGNTGLHRLR-GSFRCLVNLRFLDLSQN 313
           L  + E+ L  NR+ ++  R       L +L L +  L  ++ G+F  L N+  ++LS N
Sbjct: 313 LHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372

Query: 314 HLHHCPLQIC-ALKNLEVLGLDDNKIGQL-PSELGSLSKLKILGLTGNEFLSFPEEVL-S 370
            L + P Q+   L  L  L L+ + +G++ P     LS L+ L L  N  +   E+ L  
Sbjct: 373 CLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWG 432

Query: 371 LASLEKLYIGQDQGFKLTYVPEHI-RKLQSLKELYIENNHLEYLPV-SLGSMPNLEVLDC 428
           LA L +L +  +Q   LT++P  + + L  L+ L +  N L  LP  +LG +     LD 
Sbjct: 433 LAELLELDLTSNQ---LTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDV 489

Query: 429 RHNLLKQLPDA-ICQAQALKELRLEDNLL---THLPENLDSL 466
            HN L+ LP++ +     L+ L L +N L   T  P  L+ L
Sbjct: 490 SHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERL 531


>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
           sapiens]
          Length = 796

 Score =  114 bits (286), Expect = 2e-25
 Identities = 107/371 (28%), Positives = 160/371 (43%), Gaps = 56/371 (15%)

Query: 7   SVEHSPKIHQRNDPQHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIP-- 64
           S+ HSP     +    + D    +    + L  +PL +F    LEE+HLE    +E+   
Sbjct: 466 SLLHSPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARA 525

Query: 65  ---QEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALR 121
              + ++ LK ++VL L  N  +       +   L+ L L  +     +L  +  L ALR
Sbjct: 526 ATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALR 585

Query: 122 ELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFP 181
           EL L    L+ IP  +F +L  L+ L L  NHL+ + +EI++    R++   R       
Sbjct: 586 ELELVACGLERIPHAVF-SLGALQELDLKDNHLRSI-EEILSFQHCRKLVTLR------- 636

Query: 182 QELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDL 241
                        L  N+I  +PE +  L  L++ Y++ N L  LP+ L  CS L +LD+
Sbjct: 637 -------------LWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDV 683

Query: 242 SHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPR--LICRWTSLHLLYLGNTGLHRLRGSF 299
           SHN LHS+P     L+ +  + LS N LE +P     CR                     
Sbjct: 684 SHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCR--------------------- 722

Query: 300 RCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGN 359
                LR L L  N L      + AL+ L  L L  N++  LP ELG+   LK  GL   
Sbjct: 723 ----KLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVE 778

Query: 360 EFL--SFPEEV 368
           + L    P EV
Sbjct: 779 DTLYQGLPAEV 789



 Score =  100 bits (250), Expect = 3e-21
 Identities = 98/364 (26%), Positives = 163/364 (44%), Gaps = 12/364 (3%)

Query: 63  IPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRE 122
           +P  +  L  +  L L+     +  P L  L  L+ L L ++P      + V     L+ 
Sbjct: 429 LPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKV 488

Query: 123 LRLYQTDLKEIPVVIF--KNLHHLELLGLTGNHL-KCLPKEIVNQTK-LREIYLKRNQFE 178
           +R+   +L+E+P+ +F  + L  L L GL    L +    E + + K L+ + L+ N  +
Sbjct: 489 MRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNAGK 548

Query: 179 VFPQELCVLYTLEIIDLDENKIGAIP-EEIGHLTGLQKFYMASNNLPVLPASLCQCSQLS 237
           V      V   L+ + L  +    +    +  L  L++  + +  L  +P ++     L 
Sbjct: 549 VPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQ 608

Query: 238 VLDLSHNLLHSIPK--SFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRL 295
            LDL  N L SI +  SF   RK+  + L  N++  VP  + +  SL  LYL    L  L
Sbjct: 609 ELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETL 668

Query: 296 RGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILG 355
                    LR LD+S N LH  P ++  L+NL+ L L  N +  LP EL    KL+ L 
Sbjct: 669 PSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLL 728

Query: 356 LTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKE--LYIENNHLEYL 413
           L  N+       V +L +L +L +   +G +L  +PE +     LK+  L +E+   + L
Sbjct: 729 LGDNQLSQLSPHVGALRALSRLEL---KGNRLEALPEELGNCGGLKKAGLLVEDTLYQGL 785

Query: 414 PVSL 417
           P  +
Sbjct: 786 PAEV 789



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 100/334 (29%), Positives = 148/334 (44%), Gaps = 21/334 (6%)

Query: 166 KLREIYLKRNQFEVFPQELCVLYTL-----EIIDLDENKIGAI-----PEEIGHLTGLQK 215
           KLR+  L+RN        LC+L  L     E+ +++  ++ AI     P  +  L  LQ+
Sbjct: 406 KLRQ-KLQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQE 464

Query: 216 FYMASNNLPVLPASLCQC--SQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVP 273
             +  +    LP SL       L V+ +    L  +P     LR + E+ L G   +++ 
Sbjct: 465 LSLLHSPAR-LPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELA 523

Query: 274 RLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLG- 332
           R     +   L  L    L    G     V      L +  LH+   ++ AL +L+ L  
Sbjct: 524 RAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAA 583

Query: 333 -----LDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKL 387
                L    + ++P  + SL  L+ L L  N   S  EE+LS     KL   +    ++
Sbjct: 584 LRELELVACGLERIPHAVFSLGALQELDLKDNHLRSI-EEILSFQHCRKLVTLRLWHNQI 642

Query: 388 TYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALK 447
            YVPEH+RKL+SL++LY+  N LE LP  LG    L +LD  HN L  LP  +   Q L+
Sbjct: 643 AYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQ 702

Query: 448 ELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEE 481
            L L  N L  LPE L     L+ L L DN + +
Sbjct: 703 HLALSYNALEALPEELFFCRKLRTLLLGDNQLSQ 736


>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
          Length = 301

 Score =  114 bits (284), Expect = 3e-25
 Identities = 63/213 (29%), Positives = 114/213 (53%), Gaps = 1/213 (0%)

Query: 139 KNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDEN 198
           + +HH+    L    +  +P  +   ++++++ L  NQ  V P E+  L  + +++L  N
Sbjct: 46  RGMHHVSF-SLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGN 104

Query: 199 KIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRK 258
           ++ ++P E+  L  L+  ++  N L  +PA L  C +L VL LSHN L  +P  FA+L +
Sbjct: 105 RLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSR 164

Query: 259 MTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHC 318
           + ++ LS N    +P  +     L  L++G+  L  +  S + L +L+      N++H  
Sbjct: 165 LRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSF 224

Query: 319 PLQICALKNLEVLGLDDNKIGQLPSELGSLSKL 351
           P  +C + +LE+L L++N I  LPSEL  L +L
Sbjct: 225 PRSLCLVTSLELLNLNNNDIQTLPSELHLLCRL 257



 Score =  102 bits (254), Expect = 9e-22
 Identities = 80/288 (27%), Positives = 134/288 (46%), Gaps = 40/288 (13%)

Query: 216 FYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRL 275
           F + +  +  +P  L   S++  L+LSHN L  +P    +L ++  + L GNRL+ +PR 
Sbjct: 53  FSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPRE 112

Query: 276 ICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDD 335
           +     L +L+                       ++ N L   P ++   + LEVL L  
Sbjct: 113 VSLLQCLKVLF-----------------------VNMNCLTEVPAELSLCRKLEVLSLSH 149

Query: 336 NKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIR 395
           N + QLP+    LS+L+ L L+ N F   P  V SL  L  L++G +   +L  + E I+
Sbjct: 150 NCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSN---RLENIAESIQ 206

Query: 396 KLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNL 455
            L SL+    E N++   P SL  + +LE+L+  +N ++ LP          EL L   L
Sbjct: 207 HLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLP---------SELHLLCRL 257

Query: 456 LTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRN 503
           +      +D     K L +  NP+ +P  E+   G E ++ YLK+ ++
Sbjct: 258 VRIAWNPMD-----KGLHISHNPLSKPLPELVEGGLEMLFGYLKDKKH 300



 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 64/228 (28%), Positives = 109/228 (47%), Gaps = 25/228 (10%)

Query: 35  QSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLS 94
           + +T IP  ++  +E+++++L +NQ+  +P E+ +L  I VL L  N L+SL   + LL 
Sbjct: 58  RGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQ 117

Query: 95  SLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHL 154
            L+ L ++ N                         L E+P  +      LE+L L+ N L
Sbjct: 118 CLKVLFVNMNC------------------------LTEVPAEL-SLCRKLEVLSLSHNCL 152

Query: 155 KCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQ 214
             LP    + ++LR++ L  N F   P  +  L  L  + +  N++  I E I HL  LQ
Sbjct: 153 SQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQ 212

Query: 215 KFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEI 262
            F    NN+   P SLC  + L +L+L++N + ++P     L ++  I
Sbjct: 213 IFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRI 260



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 54/180 (30%), Positives = 94/180 (52%)

Query: 203 IPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEI 262
           IP+ +  L+ +QK  ++ N L VLP  + + +++ VL+L  N L S+P+  + L+ +  +
Sbjct: 63  IPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVL 122

Query: 263 GLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQI 322
            ++ N L +VP  +     L +L L +  L +L   F  L  LR L+LS N   H P+ +
Sbjct: 123 FVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCV 182

Query: 323 CALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQD 382
            +LK L  L +  N++  +   +  L+ L+I    GN   SFP  +  + SLE L +  +
Sbjct: 183 FSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNN 242



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 50/178 (28%), Positives = 94/178 (52%), Gaps = 2/178 (1%)

Query: 30  IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
           ++ S+  L  +P E+   T +  ++L  N+++ +P+E+  L+ ++VL+++ N L  +   
Sbjct: 76  LNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAE 135

Query: 90  LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
           L L   LE L LS+N   S      + L  LR+L L       IP+ +F +L  L  L +
Sbjct: 136 LSLCRKLEVLSLSHN-CLSQLPACFADLSRLRKLNLSNNFFAHIPMCVF-SLKELIFLHV 193

Query: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEI 207
             N L+ + + I +   L+    + N    FP+ LC++ +LE+++L+ N I  +P E+
Sbjct: 194 GSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSEL 251



 Score = 30.8 bits (68), Expect = 3.4
 Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 1/50 (2%)

Query: 21  QHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRL 70
           QH+     FI A   ++ + P  +   T LE ++L NN I+ +P E+  L
Sbjct: 206 QHLASLQIFI-AEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLL 254


>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
          Length = 347

 Score =  111 bits (277), Expect = 2e-24
 Identities = 69/217 (31%), Positives = 109/217 (50%), Gaps = 2/217 (0%)

Query: 53  VHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLV 112
           + L   ++ ++P  + +L  ++ L L  N +  +CP L  L+ L +L+L  N +      
Sbjct: 19  ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNN-LLEEVPE 77

Query: 113 VVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYL 172
            + +L +L+ L L    +          L +L LL L  NHL  LP+E+     L  + +
Sbjct: 78  EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSI 137

Query: 173 KRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQ 232
             NQ    P+ELC L  L  + L+ N++  IPEEI  L  LQK  +A NN+ VLP  LC 
Sbjct: 138 NYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCD 197

Query: 233 CSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRL 269
             +L +LD++ N++   P  F +L K+ E    GN L
Sbjct: 198 LKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPL 233



 Score =  103 bits (257), Expect = 4e-22
 Identities = 67/224 (29%), Positives = 112/224 (50%), Gaps = 25/224 (11%)

Query: 191 EIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIP 250
           +II L+  K+  +P  +G L GL+   + +N +P +   LC  +QL+ L+L +NLL  +P
Sbjct: 17  KIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVP 76

Query: 251 KSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDL 310
           +    L  +  + LSGNR       ICR+                 G+   L NL  L+L
Sbjct: 77  EEMKYLTSLKNLHLSGNR-------ICRFAP---------------GACDGLQNLILLNL 114

Query: 311 SQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLS 370
           + NHL   P ++  LK+L  + ++ N++  +P EL  L  L  L L  N+ +  PEE+  
Sbjct: 115 NNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKF 174

Query: 371 LASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLP 414
           L  L+KL + ++    +  +PE +  L+ L+ L I  N ++  P
Sbjct: 175 LKKLQKLLLARN---NIGVLPEELCDLKKLRILDIAGNIIQIFP 215



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 75/275 (27%), Positives = 124/275 (45%), Gaps = 29/275 (10%)

Query: 145 ELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIP 204
           +++ L G  +  +P  +     L+ + L+ N       ELC L  L  ++L  N +  +P
Sbjct: 17  KIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVP 76

Query: 205 EEIGHLTGLQKFYMASNNLPVLPASLCQCSQ-LSVLDLSHNLLHSIPKSFAELRKMTEIG 263
           EE+ +LT L+  +++ N +       C   Q L +L+L++N L  +P+  + L+ +T + 
Sbjct: 77  EEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMS 136

Query: 264 LSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQIC 323
           ++ N+L  +PR +C                        L NL  L L+ N L   P +I 
Sbjct: 137 INYNQLASIPRELC-----------------------FLENLVELQLNYNQLICIPEEIK 173

Query: 324 ALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQ 383
            LK L+ L L  N IG LP EL  L KL+IL + GN    FP     L  L + Y   + 
Sbjct: 174 FLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNP 232

Query: 384 GF----KLTYVPEHIRKLQSLKELYIENNHLEYLP 414
            F     ++   E++  LQ +   ++ N   E  P
Sbjct: 233 LFLQQPVISTQQENVWSLQEITSRFVMNQLAENNP 267



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 55/184 (29%), Positives = 92/184 (50%), Gaps = 2/184 (1%)

Query: 304 NLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLS 363
           N + + L+   +   P  +  L  L+ L L +N I ++  EL +L++L  L L  N    
Sbjct: 15  NTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEE 74

Query: 364 FPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNL 423
            PEE+  L SL+ L++  ++  +  + P     LQ+L  L + NNHL  LP  +  + +L
Sbjct: 75  VPEEMKYLTSLKNLHLSGNRICR--FAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSL 132

Query: 424 EVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPP 483
             +   +N L  +P  +C  + L EL+L  N L  +PE +  L  L+ L L  N +   P
Sbjct: 133 TYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLP 192

Query: 484 KEVC 487
           +E+C
Sbjct: 193 EELC 196



 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 62/193 (32%), Positives = 99/193 (51%), Gaps = 8/193 (4%)

Query: 34  NQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP-ALGL 92
           N  +  +  E+   T+L  ++L NN +EE+P+E++ L +++ L+L  N +    P A   
Sbjct: 46  NNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDG 105

Query: 93  LSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIP--VVIFKNLHHLELLGLT 150
           L +L  L+L+ N + +     VS L +L  + +    L  IP  +   +NL  L+   L 
Sbjct: 106 LQNLILLNLNNNHL-TQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQ---LN 161

Query: 151 GNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHL 210
            N L C+P+EI    KL+++ L RN   V P+ELC L  L I+D+  N I   P     L
Sbjct: 162 YNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL 221

Query: 211 TGLQKFYMASNNL 223
             L++FY   N L
Sbjct: 222 K-LREFYCEGNPL 233



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 64/238 (26%), Positives = 105/238 (44%), Gaps = 33/238 (13%)

Query: 262 IGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQ 321
           I L+G ++ K+P  + +   L  L L N  + ++                      CP +
Sbjct: 19  ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKV----------------------CP-E 55

Query: 322 ICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQ 381
           +C L  L  L L +N + ++P E+  L+ LK L L+GN    F         L+ L +  
Sbjct: 56  LCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACD--GLQNLILLN 113

Query: 382 DQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAIC 441
                LT +P+ + +L+SL  + I  N L  +P  L  + NL  L   +N L  +P+ I 
Sbjct: 114 LNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIK 173

Query: 442 QAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPP--------KEVCAEGN 491
             + L++L L  N +  LPE L  L  L++L +  N ++  P        +E   EGN
Sbjct: 174 FLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGN 231



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 24/80 (30%), Positives = 43/80 (53%)

Query: 398 QSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLT 457
           ++ K + +    +  +P +LG +P L+ L  ++NL+ ++   +C    L  L L +NLL 
Sbjct: 14  KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73

Query: 458 HLPENLDSLVNLKVLTLMDN 477
            +PE +  L +LK L L  N
Sbjct: 74  EVPEEMKYLTSLKNLHLSGN 93



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 27/78 (34%), Positives = 42/78 (53%)

Query: 29  FIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           ++  +   L +IP E+     L E+ L  NQ+  IP+EI+ LK ++ L L +NN+  L  
Sbjct: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPE 193

Query: 89  ALGLLSSLESLDLSYNPI 106
            L  L  L  LD++ N I
Sbjct: 194 ELCDLKKLRILDIAGNII 211



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 37/146 (25%), Positives = 63/146 (43%), Gaps = 26/146 (17%)

Query: 30  IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
           ++ +N  LT +P E+     L  + +  NQ+  IP+E                   LC  
Sbjct: 112 LNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRE-------------------LC-- 150

Query: 90  LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
              L +L  L L+YN +       + FL  L++L L + ++  +P  +  +L  L +L +
Sbjct: 151 --FLENLVELQLNYNQLICIP-EEIKFLKKLQKLLLARNNIGVLPEELC-DLKKLRILDI 206

Query: 150 TGNHLKCLPKEIVNQTKLREIYLKRN 175
            GN ++  P       KLRE Y + N
Sbjct: 207 AGNIIQIFPSGF-QDLKLREFYCEGN 231



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 25/96 (26%), Positives = 47/96 (48%), Gaps = 9/96 (9%)

Query: 416 SLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLM 475
           +L    N +++      + ++P A+ +   LK L L++NL+  +   L +L  L  L L 
Sbjct: 9   ALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLG 68

Query: 476 DNPMEEPPKEVCAEGNEAIWKYLKENRNRNIMATKI 511
           +N +EE P+E+         KYL   +N ++   +I
Sbjct: 69  NNLLEEVPEEM---------KYLTSLKNLHLSGNRI 95


>gi|37221175 PH domain and leucine rich repeat protein phosphatase
           [Homo sapiens]
          Length = 1205

 Score =  110 bits (276), Expect = 3e-24
 Identities = 131/508 (25%), Positives = 227/508 (44%), Gaps = 56/508 (11%)

Query: 7   SVEHSP-KIHQRNDPQHVNDRTFFIDASNQSLTAIP--LEIFTFTELEEVHLENNQIEEI 63
           S+EH P  +    D  H+N +  F+   N SL A     E+  FT+L+ ++L NN + + 
Sbjct: 136 SLEHLPANLFYSQDLTHLNLKQNFL-RQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDF 194

Query: 64  PQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALREL 123
           P  +  +  +  L +  N LRS+  A+G++ +L++  L  N    S    +  +  L  L
Sbjct: 195 PLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGN-FLQSLPAELENMKQLSYL 253

Query: 124 RLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQ-TKLREIYLKRNQF-EVFP 181
            L   +  +IP V+ K L  ++ L ++GN ++ L  + + +   ++ + L+ N   ++  
Sbjct: 254 GLSFNEFTDIPEVLEK-LTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIA 312

Query: 182 QELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDL 241
            E+  L  +  +DL +NK+G +              M  NN+ VL    C+ +QL  LD+
Sbjct: 313 DEVDFLQHVTQLDLRDNKLGDLDA------------MIFNNIEVLH---CERNQLVTLDI 357

Query: 242 SHNLLHSIPKSFAEL---------RKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGL 292
               L ++  S  EL           ++ + +S NRLE VP  +C    L +L +G+  +
Sbjct: 358 CGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQI 417

Query: 293 HRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSE-LGSLSKL 351
             L     C  +LR L    N L   P ++    ++EVL +  N++ +LP   L     L
Sbjct: 418 CELPARLFCNSSLRKLLAGHNQLARLPERL-ERTSVEVLDVQHNQLLELPPNLLMKADSL 476

Query: 352 KILGLTGNEFLSFPEEVLSLAS---LEKLYIGQ----DQGFKLTYVPEHIRKLQSLKELY 404
           + L  + N+  S P   LS  +   L++LY+      D+   L     H      LK L+
Sbjct: 477 RFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPH------LKILH 530

Query: 405 IENNHLEYLPVS-LGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENL 463
           +  N L+  P S +  +  LE +D   N LK +P  I   + +  +    N +   PE +
Sbjct: 531 MAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVM 590

Query: 464 DSLVNLKVLTLMDNPMEE-------PPK 484
             L  +K + L  N + E       PPK
Sbjct: 591 -QLPEIKCVDLSCNELSEVTLPENLPPK 617



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 96/384 (25%), Positives = 174/384 (45%), Gaps = 44/384 (11%)

Query: 130 LKEIPVVIFKNLHHLELLGLTGNHLKCLPK--------EIVNQTKLREIYLKRNQFEVFP 181
           L+ +P  +F +   L  L L  N L+  P         E+   TKL+ + L  N    FP
Sbjct: 137 LEHLPANLFYS-QDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFP 195

Query: 182 QELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDL 241
             +C + TL  +++  N + ++P  +G +  LQ F +  N L  LPA L    QLS L L
Sbjct: 196 LAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGL 255

Query: 242 SHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRC 301
           S N    IP+   +L  + ++ +SGN +E +                     RL+ + R 
Sbjct: 256 SFNEFTDIPEVLEKLTAVDKLCMSGNCVETL---------------------RLQ-ALRK 293

Query: 302 LVNLRFLDLSQNHLHHCPL-QICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNE 360
           + +++ +DL  N +      ++  L+++  L L DNK+G L + +   + +++L    N+
Sbjct: 294 MPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMI--FNNIEVLHCERNQ 351

Query: 361 FLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSM 420
            ++     +    L+ LY   ++  +L   P        L  + +  N LE +P  +   
Sbjct: 352 LVTLD---ICGYFLKALYASSNELVQLDVYPVP----NYLSYMDVSRNRLENVPEWVCES 404

Query: 421 PNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPME 480
             LEVLD  HN + +LP  +    +L++L    N L  LPE L+   +++VL +  N + 
Sbjct: 405 RKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLER-TSVEVLDVQHNQLL 463

Query: 481 EPPKEVCAEGNEAIWKYLKENRNR 504
           E P  +  + +    ++L  + N+
Sbjct: 464 ELPPNLLMKADSL--RFLNASANK 485



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 110/481 (22%), Positives = 213/481 (44%), Gaps = 36/481 (7%)

Query: 30  IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
           ++ S  +L ++P  +     L+   L+ N ++ +P E++ +K +  L L  N    +   
Sbjct: 207 LNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEV 266

Query: 90  LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
           L  L++++ L +S N + +  L  +  +  ++ + L    ++++       L H+  L L
Sbjct: 267 LEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDL 326

Query: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQ---FEVFPQELCVLY--TLEIIDLDENKIGAIP 204
             N L  L   I N  ++  ++ +RNQ    ++    L  LY  + E++ LD   +  +P
Sbjct: 327 RDNKLGDLDAMIFNNIEV--LHCERNQLVTLDICGYFLKALYASSNELVQLD---VYPVP 381

Query: 205 EEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGL 264
             + ++       ++ N L  +P  +C+  +L VLD+ HN +  +P        + ++  
Sbjct: 382 NYLSYMD------VSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLA 435

Query: 265 SGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLV-NLRFLDLSQNHLHHCPLQIC 323
             N+L ++P  + R TS+ +L + +  L  L  +      +LRFL+ S N L   P    
Sbjct: 436 GHNQLARLPERLER-TSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATL 494

Query: 324 ALKN---LEVLGLDDNKI-GQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYI 379
           + +    L+ L L +N +  +    L     LKIL +  N   SFP     +A LE+L  
Sbjct: 495 SEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPAS--KMAKLEELEE 552

Query: 380 GQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDA 439
               G KL  +P  I   + +  +   +N +E  P  +  +P ++ +D   N L ++   
Sbjct: 553 IDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVDLSCNELSEVTLP 611

Query: 440 ICQAQALKELRLEDN---LLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWK 496
                 L+EL L  N   +L H  + L+ L N++   +      + P    A G  A+W 
Sbjct: 612 ENLPPKLQELDLTGNPRLVLDH--KTLELLNNIRCFKI------DQPSTGDASGAPAVWS 663

Query: 497 Y 497
           +
Sbjct: 664 H 664



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 11/160 (6%)

Query: 308 LDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPS--------ELGSLSKLKILGLTGN 359
           +DLS   L H P  +   ++L  L L  N + Q PS        EL   +KLK L L+ N
Sbjct: 130 VDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNN 189

Query: 360 EFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGS 419
               FP  V S+ +L +L +  +    L  VP  +  + +L+   ++ N L+ LP  L +
Sbjct: 190 HLGDFPLAVCSIPTLAELNVSCN---ALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELEN 246

Query: 420 MPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHL 459
           M  L  L    N    +P+ + +  A+ +L +  N +  L
Sbjct: 247 MKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETL 286


>gi|197333706 leucine rich repeat containing 8 family, member D
           [Homo sapiens]
          Length = 858

 Score =  109 bits (273), Expect = 6e-24
 Identities = 108/400 (27%), Positives = 190/400 (47%), Gaps = 39/400 (9%)

Query: 37  LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96
           L+ +P  +F  T+L+ + LE     +IP +I ++ N++ L+L        CPA       
Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCH------CPA------- 525

Query: 97  ESLDLSYNPIFSSSLVVVSFLHA-LRELRLYQTDLKEIP--VVIFKNLHHLELLG-LTGN 152
                             SFL   LR L +  TD+ EIP  V + KNL  L L+G L   
Sbjct: 526 -----------KVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSE 574

Query: 153 HLKCLPKEIVNQTK-LREIYLKRNQFEVFPQ--ELCVLYTLEIIDLDENKIGAIPEEIGH 209
           + K +  E + + + L+ +++K N  +V     ++    T  +I  D  K+  +   +  
Sbjct: 575 NNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKL-LVLNSLKK 633

Query: 210 LTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPK--SFAELRKMTEIGLSGN 267
           +  + +  + +  L  +P ++   S L  LDL  N + +I +  SF  L+++T + L  N
Sbjct: 634 MMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHN 693

Query: 268 RLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKN 327
           ++  +P  I    +L  LY  N  L  L  +   L  LR LD+S N++   P++I  L+N
Sbjct: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753

Query: 328 LEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKL 387
           L+ L +  NK+  LP +L    KL+ L L  N   S PE+V  L+ L +L +   +G  L
Sbjct: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLEL---KGNCL 810

Query: 388 TYVPEHIRKLQSLKE--LYIENNHLEYLPVSLGSMPNLEV 425
             +P  + + + LK+  L +E++  + LP+ +    N ++
Sbjct: 811 DRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQDI 850



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 72/295 (24%), Positives = 138/295 (46%), Gaps = 33/295 (11%)

Query: 10  HSPKIHQRNDPQHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHL------ENNQIEEI 63
           H P   ++     + D    +      +  IP  ++    L E++L      ENN++  +
Sbjct: 522 HCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGL 581

Query: 64  PQEIQRLKNIRVLYLDKN------NLRSLCPALG------------LLSSLESLDLSYNP 105
            + ++ L+++++L++  N      N+  + P L             +L+SL+ + ++   
Sbjct: 582 -ESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKM-MNVAE 639

Query: 106 IFSSSLVVVSFLHA------LRELRLYQTDLKEIPVVI-FKNLHHLELLGLTGNHLKCLP 158
           +   +  +    HA      L+EL L   +++ I  +I F++L  L  L L  N +  +P
Sbjct: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699

Query: 159 KEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYM 218
             I +   L  +Y   N+ E  P  +  L  L  +D+  N I  IP EIG L  LQ  ++
Sbjct: 700 PSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHI 759

Query: 219 ASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVP 273
             N + +LP  L +C +L  L+L  N + S+P+   +L ++T++ L GN L+++P
Sbjct: 760 TGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 97/372 (26%), Positives = 165/372 (44%), Gaps = 32/372 (8%)

Query: 121 RELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVF 180
           +EL L+   L  +P  +F +L  L++L L       +P +I   T L+E++L     +V 
Sbjct: 472 QELHLFM--LSGVPDAVF-DLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVE 528

Query: 181 PQELCVLYT-LEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVL 239
                 L   L  + +    +  IP  +  L  L++ Y+  N                 L
Sbjct: 529 QTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN-----------------L 571

Query: 240 DLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHL--LYLGNTGLHRL-R 296
           +  +N +  + +S  ELR +  + +  N L KVP  I    + HL  L + N G   L  
Sbjct: 572 NSENNKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITD-VAPHLTKLVIHNDGTKLLVL 628

Query: 297 GSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELG--SLSKLKIL 354
            S + ++N+  L+L    L   P  I +L NL+ L L  N I  +   +    L +L  L
Sbjct: 629 NSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCL 688

Query: 355 GLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLP 414
            L  N+ ++ P  +  + +LE LY   +   KL  +P  +  LQ L+ L +  N++  +P
Sbjct: 689 KLWHNKIVTIPPSITHVKNLESLYFSNN---KLESLPVAVFSLQKLRCLDVSYNNISMIP 745

Query: 415 VSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTL 474
           + +G + NL+ L    N +  LP  + +   L+ L L  N +T LPE +  L  L  L L
Sbjct: 746 IEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLEL 805

Query: 475 MDNPMEEPPKEV 486
             N ++  P ++
Sbjct: 806 KGNCLDRLPAQL 817


>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
           sapiens]
          Length = 858

 Score =  109 bits (273), Expect = 6e-24
 Identities = 108/400 (27%), Positives = 190/400 (47%), Gaps = 39/400 (9%)

Query: 37  LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96
           L+ +P  +F  T+L+ + LE     +IP +I ++ N++ L+L        CPA       
Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCH------CPA------- 525

Query: 97  ESLDLSYNPIFSSSLVVVSFLHA-LRELRLYQTDLKEIP--VVIFKNLHHLELLG-LTGN 152
                             SFL   LR L +  TD+ EIP  V + KNL  L L+G L   
Sbjct: 526 -----------KVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSE 574

Query: 153 HLKCLPKEIVNQTK-LREIYLKRNQFEVFPQ--ELCVLYTLEIIDLDENKIGAIPEEIGH 209
           + K +  E + + + L+ +++K N  +V     ++    T  +I  D  K+  +   +  
Sbjct: 575 NNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKL-LVLNSLKK 633

Query: 210 LTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPK--SFAELRKMTEIGLSGN 267
           +  + +  + +  L  +P ++   S L  LDL  N + +I +  SF  L+++T + L  N
Sbjct: 634 MMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHN 693

Query: 268 RLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKN 327
           ++  +P  I    +L  LY  N  L  L  +   L  LR LD+S N++   P++I  L+N
Sbjct: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753

Query: 328 LEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKL 387
           L+ L +  NK+  LP +L    KL+ L L  N   S PE+V  L+ L +L +   +G  L
Sbjct: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLEL---KGNCL 810

Query: 388 TYVPEHIRKLQSLKE--LYIENNHLEYLPVSLGSMPNLEV 425
             +P  + + + LK+  L +E++  + LP+ +    N ++
Sbjct: 811 DRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQDI 850



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 72/295 (24%), Positives = 138/295 (46%), Gaps = 33/295 (11%)

Query: 10  HSPKIHQRNDPQHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHL------ENNQIEEI 63
           H P   ++     + D    +      +  IP  ++    L E++L      ENN++  +
Sbjct: 522 HCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGL 581

Query: 64  PQEIQRLKNIRVLYLDKN------NLRSLCPALG------------LLSSLESLDLSYNP 105
            + ++ L+++++L++  N      N+  + P L             +L+SL+ + ++   
Sbjct: 582 -ESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKM-MNVAE 639

Query: 106 IFSSSLVVVSFLHA------LRELRLYQTDLKEIPVVI-FKNLHHLELLGLTGNHLKCLP 158
           +   +  +    HA      L+EL L   +++ I  +I F++L  L  L L  N +  +P
Sbjct: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699

Query: 159 KEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYM 218
             I +   L  +Y   N+ E  P  +  L  L  +D+  N I  IP EIG L  LQ  ++
Sbjct: 700 PSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHI 759

Query: 219 ASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVP 273
             N + +LP  L +C +L  L+L  N + S+P+   +L ++T++ L GN L+++P
Sbjct: 760 TGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 97/372 (26%), Positives = 165/372 (44%), Gaps = 32/372 (8%)

Query: 121 RELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVF 180
           +EL L+   L  +P  +F +L  L++L L       +P +I   T L+E++L     +V 
Sbjct: 472 QELHLFM--LSGVPDAVF-DLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVE 528

Query: 181 PQELCVLYT-LEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVL 239
                 L   L  + +    +  IP  +  L  L++ Y+  N                 L
Sbjct: 529 QTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN-----------------L 571

Query: 240 DLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHL--LYLGNTGLHRL-R 296
           +  +N +  + +S  ELR +  + +  N L KVP  I    + HL  L + N G   L  
Sbjct: 572 NSENNKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITD-VAPHLTKLVIHNDGTKLLVL 628

Query: 297 GSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELG--SLSKLKIL 354
            S + ++N+  L+L    L   P  I +L NL+ L L  N I  +   +    L +L  L
Sbjct: 629 NSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCL 688

Query: 355 GLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLP 414
            L  N+ ++ P  +  + +LE LY   +   KL  +P  +  LQ L+ L +  N++  +P
Sbjct: 689 KLWHNKIVTIPPSITHVKNLESLYFSNN---KLESLPVAVFSLQKLRCLDVSYNNISMIP 745

Query: 415 VSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTL 474
           + +G + NL+ L    N +  LP  + +   L+ L L  N +T LPE +  L  L  L L
Sbjct: 746 IEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLEL 805

Query: 475 MDNPMEEPPKEV 486
             N ++  P ++
Sbjct: 806 KGNCLDRLPAQL 817


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score =  108 bits (271), Expect = 1e-23
 Identities = 107/351 (30%), Positives = 167/351 (47%), Gaps = 21/351 (5%)

Query: 33  SNQSLTAIPLEI------FTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSL 86
           S++ L  +PL+I        F E     LE       P         +V++L+    +  
Sbjct: 36  SDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLT------KVVFLNTQLCQFR 89

Query: 87  CPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLEL 146
             A G L  LE L+++ +   + S  + S L +L +L L    L+ +P  +F++L  LE 
Sbjct: 90  PDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALES 149

Query: 147 LGLTGNHLKCLPKEIVNQ-TKLREIYLKRNQFEVFPQELC-VLYTLEIIDLDENKIGAIP 204
           L L GN L+ LP+ +    T L+ + L +N     P+EL   L +L+ + L  N +  +P
Sbjct: 150 LHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLP 209

Query: 205 EEI-GHLTGLQKFYMASNNLPVLPASL-CQCSQLSVLDLSHNLLHSIPKS-FAELRKMTE 261
           + + G L  LQ+ ++ SNN+  LP  +  Q   L  L L  N +  +P S FA L  +T 
Sbjct: 210 QGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTF 269

Query: 262 IGLSGNRLEKVPR-LICRWTSLHLLYLGNTGLHRL-RGSFRCLVNLRFLDLSQNHLHHCP 319
           + L  N L  +P  L      L  L L +  L  +  G+F  L NLR L LS N + H P
Sbjct: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLP 329

Query: 320 LQICA-LKNLEVLGLDDNKIGQL-PSELGSLSKLKILGLTGNEFLSFPEEV 368
             I   L+ L  L L  N +  L P+   +LSKL++L L+ N+  + PE +
Sbjct: 330 AGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGI 380



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 97/331 (29%), Positives = 149/331 (45%), Gaps = 35/331 (10%)

Query: 120 LRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIV-NQTKLREIYLKRNQFE 178
           L ++    T L +     F  L  LE L +TG+    L   I  N T L ++ L  N  E
Sbjct: 75  LTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLE 134

Query: 179 VFPQELCV-LYTLEIIDLDENKIGAIPEEIGH-LTGLQKFYMASNNLPVLPASLCQ-CSQ 235
             P+ L   L  LE + L  N++ A+P  +   LT L+   +A N L  LP  L    + 
Sbjct: 135 ALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTS 194

Query: 236 LSVLDLSHNLLHSIPKS-FAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHR 294
           L  L LS+N L  +P+  F +L  + E+ L  N + ++P  +                  
Sbjct: 195 LQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQV------------------ 236

Query: 295 LRGSFRCLVNLRFLDLSQNHLHHCPLQICA-LKNLEVLGLDDNKIGQLPSELGSLSKLKI 353
               F  L  L  L L +N + H PL I A L NL  L L  N +  LP+ L + +   +
Sbjct: 237 ----FSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLV 292

Query: 354 -LGLTGNEFLSFPEEVLS-LASLEKLYIGQDQGFKLTYVPEHI-RKLQSLKELYIENNHL 410
            L LT N+  +  E   + L++L  L +  +    +T++P  I R L+ L +LY+ +N+L
Sbjct: 293 GLSLTHNQLETVAEGTFAHLSNLRSLMLSYNA---ITHLPAGIFRDLEELVKLYLGSNNL 349

Query: 411 EYL-PVSLGSMPNLEVLDCRHNLLKQLPDAI 440
             L P    ++  LE+L    N L  LP+ I
Sbjct: 350 TALHPALFQNLSKLELLSLSKNQLTTLPEGI 380



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 49/153 (32%), Positives = 85/153 (55%), Gaps = 8/153 (5%)

Query: 342 PSELGSLSKLKILGLTGNEFLSFPEEVLS-LASLEKLYIGQDQGFKLTYVPEHI-RKLQS 399
           P   G L +L+ L +TG+ FL+    + S L SL KL +  +    L  +PE + + L +
Sbjct: 90  PDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNM---LEALPEGLFQHLAA 146

Query: 400 LKELYIENNHLEYLPVSL-GSMPNLEVLDCRHNLLKQLPDAICQ-AQALKELRLEDNLLT 457
           L+ L+++ N L+ LP  L   + +L+ L+   NLL QLP+ +     +L+ L+L +N L+
Sbjct: 147 LESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALS 206

Query: 458 HLPENL-DSLVNLKVLTLMDNPMEEPPKEVCAE 489
            LP+ +   L +L+ L L  N + E P +V ++
Sbjct: 207 GLPQGVFGKLGSLQELFLDSNNISELPPQVFSQ 239



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 51/160 (31%), Positives = 73/160 (45%), Gaps = 29/160 (18%)

Query: 29  FIDASNQSLTAIPLEIFT-FTELEEVHLENNQIEEIPQEI-QRLKNIRVLYLDKNNLRSL 86
           F+D++N  ++ +P ++F+    LE + L+ N I  +P  I   L N+  L L  N LR L
Sbjct: 223 FLDSNN--ISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVL 280

Query: 87  CPAL--------GL-----------------LSSLESLDLSYNPIFSSSLVVVSFLHALR 121
              L        GL                 LS+L SL LSYN I      +   L  L 
Sbjct: 281 PAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELV 340

Query: 122 ELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEI 161
           +L L   +L  +   +F+NL  LELL L+ N L  LP+ I
Sbjct: 341 KLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGI 380


>gi|45505137 podocan [Homo sapiens]
          Length = 661

 Score =  107 bits (266), Expect = 4e-23
 Identities = 141/503 (28%), Positives = 229/503 (45%), Gaps = 81/503 (16%)

Query: 20  PQHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEE--IPQE-IQRLKNIRVL 76
           P+H N  +     +NQ     P E+     LE ++L+NN++    +P++  + L N+  L
Sbjct: 143 PEHTNHLSL---QNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYL 199

Query: 77  YLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKE--IP 134
           YL  N L +L P   L ++L S+D + N +     +       LR + L+   L +  +P
Sbjct: 200 YLANNKL-TLAPRF-LPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLP 257

Query: 135 VVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQ-ELCVLYTLEII 193
             +F    ++E+L L+ N L+ +PK +     L +++LK N+ E  P      L +L  +
Sbjct: 258 DNMFNGSSNVEVLILSSNFLRHVPKHL--PPALYKLHLKNNKLEKIPPGAFSELSSLREL 315

Query: 194 DLDENKI---GAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLD---------- 240
            L  N +   G   E    L+ L+   ++SNNL  +PA L +   L  L+          
Sbjct: 316 YLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDAN 375

Query: 241 -------LSHNLLHSI--------PKSFAELRKMTEIGLSGNRLEKVPR-LICRWTSLHL 284
                  L + LLHS         P +F  L+++  + L  N LE+VP  L  R  +L +
Sbjct: 376 VLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMI 435

Query: 285 LYLGNTGLHRL------------------------RGSFRCLVNLRFLDLSQNHLHHCPL 320
           L+   TG+ R                         R +FR L  LR LDLS N LH  P 
Sbjct: 436 LHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPP 495

Query: 321 QICALKNLEVLGLDDNKIGQLP-SELGSLSKLKILGLTGNEFLS---FPEEVLSLASLEK 376
            +   +N+ VL +  N++  L    L  +++L+ L LT N   S    P   + LA L+ 
Sbjct: 496 GL--PRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQL 553

Query: 377 LYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPV-SLGSMPNLEVLDCRHNLL-- 433
           L I    G +LT +PE +   +SL+ LY++NN +  +P  +  S PNL+ +  R N L  
Sbjct: 554 LDIA---GNQLTEIPEGLP--ESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAV 608

Query: 434 -KQLPDAICQAQALKELRLEDNL 455
              +  A  + + L+ L +E NL
Sbjct: 609 GSVVDSAFRRLKHLQVLDIEGNL 631


>gi|197333692 leucine rich repeat containing 8 family, member B
           [Homo sapiens]
          Length = 803

 Score =  106 bits (264), Expect = 6e-23
 Identities = 87/266 (32%), Positives = 124/266 (46%), Gaps = 35/266 (13%)

Query: 40  IPLEIFTFTELEEVHLEN----NQIEEIPQE-IQRLKNIRVLYLDKNNLRSLCPALGLLS 94
           IP  +F    L+E++L       Q+  +  E  Q LKN+R LYL  +  R       LL 
Sbjct: 502 IPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLP 561

Query: 95  SLESLDLSYNPIFSSSLVVVSFLHA---LRELRLYQTDLKEIPVVIFK--NLHHLEL--- 146
           SL+ L L       S LVV++ L     L+ L L   DL+ IP  IF   NLH L+L   
Sbjct: 562 SLQKLSLDNE---GSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLREN 618

Query: 147 -------------------LGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVL 187
                              L L  N++  +P +I   + L ++ L  N  E  P +L + 
Sbjct: 619 NLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLC 678

Query: 188 YTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLH 247
             L  +DL  N +  IPEEI +L+ LQ F + +NN+ +LP  L QC +L  L L  N L 
Sbjct: 679 TKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLM 738

Query: 248 SIPKSFAELRKMTEIGLSGNRLEKVP 273
           ++     EL  +T + L GN LE +P
Sbjct: 739 NLSPHVGELSNLTHLELIGNYLETLP 764



 Score =  101 bits (252), Expect = 2e-21
 Identities = 106/388 (27%), Positives = 170/388 (43%), Gaps = 35/388 (9%)

Query: 37  LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96
           L  +P  +F  TE+E + LE     ++P  + +L N++ L +  ++L    PAL  L   
Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEE- 487

Query: 97  ESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIF--KNLHHLELLG-LTGNH 153
                                  L+ LRL  T++ +IP  +F  KNL  L L G +    
Sbjct: 488 ----------------------NLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQ 525

Query: 154 LKCLPKEIVNQTK-LREIYLKRNQFEVFPQELCVLYTLEIIDLD-ENKIGAIPEEIGHLT 211
           L  +  E     K LR +YLK +   +      +L +L+ + LD E     +   +  + 
Sbjct: 526 LSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMV 585

Query: 212 GLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPK--SFAELRKMTEIGLSGNRL 269
            L+   + S +L  +P S+   + L  LDL  N L ++ +  SF  L+ ++ + L  N +
Sbjct: 586 NLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNI 645

Query: 270 EKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLE 329
             +P  I   ++L  L L +  +  L         L +LDLS NHL   P +I  L NL+
Sbjct: 646 AYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQ 705

Query: 330 VLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTY 389
              + +N I  LP  L    KL+ L L  N  ++    V  L++L  L +    G  L  
Sbjct: 706 YFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLEL---IGNYLET 762

Query: 390 VPEHIRKLQSLKE--LYIENNHLEYLPV 415
           +P  +   QSLK   L +E N L  LP+
Sbjct: 763 LPPELEGCQSLKRNCLIVEENLLNTLPL 790



 Score = 82.8 bits (203), Expect = 8e-16
 Identities = 90/333 (27%), Positives = 153/333 (45%), Gaps = 16/333 (4%)

Query: 162 VNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASN 221
           V++ KL++I L         +   V    + I+L    +  +P+ +  LT ++   +   
Sbjct: 391 VSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELI 450

Query: 222 NLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEI-GLSGNRLEKVPRLICRWT 280
               LP+++ Q   L  L + H+ L     + A L +  +I  L    + K+PR +    
Sbjct: 451 PEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLK 510

Query: 281 SLHLLYLGNTGLH------RLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLD 334
           +L  LYL    L       +L G F+ L NLR L L  +      +    L +L+ L LD
Sbjct: 511 NLKELYLSGCVLPEQLSTMQLEG-FQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLD 569

Query: 335 D--NKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPE 392
           +  +K+  L + L  +  LK L L   +    P  + SL +L +L + ++    L  V E
Sbjct: 570 NEGSKLVVL-NNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENN---LKTVEE 625

Query: 393 HI--RKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELR 450
            I  + LQ+L  L + +N++ Y+P  +G++ NLE L   HN ++ LP  +     L  L 
Sbjct: 626 IISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLD 685

Query: 451 LEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPP 483
           L  N LT +PE +  L NL+   + +N +E  P
Sbjct: 686 LSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLP 718



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 29/76 (38%), Positives = 44/76 (57%)

Query: 29  FIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           ++D S   LT IP EI   + L+   + NN IE +P  + + K ++ L L KN+L +L P
Sbjct: 683 YLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSP 742

Query: 89  ALGLLSSLESLDLSYN 104
            +G LS+L  L+L  N
Sbjct: 743 HVGELSNLTHLELIGN 758



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 39/154 (25%), Positives = 65/154 (42%), Gaps = 27/154 (17%)

Query: 30  IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
           +   + ++  +PL++F  T+L  + L  N +  IP+EIQ L N++   +  NN+  L   
Sbjct: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720

Query: 90  LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
           L     L+ L L  N + + S  V                          NL HLEL+  
Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGE----------------------LSNLTHLELI-- 756

Query: 150 TGNHLKCLPKEIVNQTKLRE--IYLKRNQFEVFP 181
            GN+L+ LP E+     L+   + ++ N     P
Sbjct: 757 -GNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789


>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
           sapiens]
          Length = 803

 Score =  106 bits (264), Expect = 6e-23
 Identities = 87/266 (32%), Positives = 124/266 (46%), Gaps = 35/266 (13%)

Query: 40  IPLEIFTFTELEEVHLEN----NQIEEIPQE-IQRLKNIRVLYLDKNNLRSLCPALGLLS 94
           IP  +F    L+E++L       Q+  +  E  Q LKN+R LYL  +  R       LL 
Sbjct: 502 IPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLP 561

Query: 95  SLESLDLSYNPIFSSSLVVVSFLHA---LRELRLYQTDLKEIPVVIFK--NLHHLEL--- 146
           SL+ L L       S LVV++ L     L+ L L   DL+ IP  IF   NLH L+L   
Sbjct: 562 SLQKLSLDNE---GSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLREN 618

Query: 147 -------------------LGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVL 187
                              L L  N++  +P +I   + L ++ L  N  E  P +L + 
Sbjct: 619 NLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLC 678

Query: 188 YTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLH 247
             L  +DL  N +  IPEEI +L+ LQ F + +NN+ +LP  L QC +L  L L  N L 
Sbjct: 679 TKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLM 738

Query: 248 SIPKSFAELRKMTEIGLSGNRLEKVP 273
           ++     EL  +T + L GN LE +P
Sbjct: 739 NLSPHVGELSNLTHLELIGNYLETLP 764



 Score =  101 bits (252), Expect = 2e-21
 Identities = 106/388 (27%), Positives = 170/388 (43%), Gaps = 35/388 (9%)

Query: 37  LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96
           L  +P  +F  TE+E + LE     ++P  + +L N++ L +  ++L    PAL  L   
Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEE- 487

Query: 97  ESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIF--KNLHHLELLG-LTGNH 153
                                  L+ LRL  T++ +IP  +F  KNL  L L G +    
Sbjct: 488 ----------------------NLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQ 525

Query: 154 LKCLPKEIVNQTK-LREIYLKRNQFEVFPQELCVLYTLEIIDLD-ENKIGAIPEEIGHLT 211
           L  +  E     K LR +YLK +   +      +L +L+ + LD E     +   +  + 
Sbjct: 526 LSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMV 585

Query: 212 GLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPK--SFAELRKMTEIGLSGNRL 269
            L+   + S +L  +P S+   + L  LDL  N L ++ +  SF  L+ ++ + L  N +
Sbjct: 586 NLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNI 645

Query: 270 EKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLE 329
             +P  I   ++L  L L +  +  L         L +LDLS NHL   P +I  L NL+
Sbjct: 646 AYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQ 705

Query: 330 VLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTY 389
              + +N I  LP  L    KL+ L L  N  ++    V  L++L  L +    G  L  
Sbjct: 706 YFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLEL---IGNYLET 762

Query: 390 VPEHIRKLQSLKE--LYIENNHLEYLPV 415
           +P  +   QSLK   L +E N L  LP+
Sbjct: 763 LPPELEGCQSLKRNCLIVEENLLNTLPL 790



 Score = 82.8 bits (203), Expect = 8e-16
 Identities = 90/333 (27%), Positives = 153/333 (45%), Gaps = 16/333 (4%)

Query: 162 VNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASN 221
           V++ KL++I L         +   V    + I+L    +  +P+ +  LT ++   +   
Sbjct: 391 VSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELI 450

Query: 222 NLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEI-GLSGNRLEKVPRLICRWT 280
               LP+++ Q   L  L + H+ L     + A L +  +I  L    + K+PR +    
Sbjct: 451 PEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLK 510

Query: 281 SLHLLYLGNTGLH------RLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLD 334
           +L  LYL    L       +L G F+ L NLR L L  +      +    L +L+ L LD
Sbjct: 511 NLKELYLSGCVLPEQLSTMQLEG-FQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLD 569

Query: 335 D--NKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPE 392
           +  +K+  L + L  +  LK L L   +    P  + SL +L +L + ++    L  V E
Sbjct: 570 NEGSKLVVL-NNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENN---LKTVEE 625

Query: 393 HI--RKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELR 450
            I  + LQ+L  L + +N++ Y+P  +G++ NLE L   HN ++ LP  +     L  L 
Sbjct: 626 IISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLD 685

Query: 451 LEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPP 483
           L  N LT +PE +  L NL+   + +N +E  P
Sbjct: 686 LSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLP 718



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 29/76 (38%), Positives = 44/76 (57%)

Query: 29  FIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           ++D S   LT IP EI   + L+   + NN IE +P  + + K ++ L L KN+L +L P
Sbjct: 683 YLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSP 742

Query: 89  ALGLLSSLESLDLSYN 104
            +G LS+L  L+L  N
Sbjct: 743 HVGELSNLTHLELIGN 758



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 39/154 (25%), Positives = 65/154 (42%), Gaps = 27/154 (17%)

Query: 30  IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
           +   + ++  +PL++F  T+L  + L  N +  IP+EIQ L N++   +  NN+  L   
Sbjct: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720

Query: 90  LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
           L     L+ L L  N + + S  V                          NL HLEL+  
Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGE----------------------LSNLTHLELI-- 756

Query: 150 TGNHLKCLPKEIVNQTKLRE--IYLKRNQFEVFP 181
            GN+L+ LP E+     L+   + ++ N     P
Sbjct: 757 -GNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789


>gi|65301141 PH domain and leucine rich repeat protein
           phosphatase-like [Homo sapiens]
          Length = 1323

 Score =  105 bits (261), Expect = 1e-22
 Identities = 114/455 (25%), Positives = 216/455 (47%), Gaps = 34/455 (7%)

Query: 40  IPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESL 99
           +P +I     L+ + L+ N +  +P+E+  L+ +  L +  NN   +      L+ L+ +
Sbjct: 337 LPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRV 396

Query: 100 DLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPK 159
            ++ N +   +L V++ ++ ++ + L    LK + +   +   H+  + L  N L  L  
Sbjct: 397 VMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDL-- 454

Query: 160 EIVNQTKLREIYLKRNQFEVFPQELCVL-YTLEIIDLDENKIGAIPEEIGHLTGLQKFYM 218
           ++ +   L +++  RNQ     +EL +  ++L  +    N++ A+   +  +  L  F  
Sbjct: 455 DLSSLCSLEQLHCGRNQL----RELTLSGFSLRTLYASSNRLTAV--NVYPVPSLLTFLD 508

Query: 219 ASNN-LPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLIC 277
            S N L  +P   C+  ++ VLD+S+NLL  +P        + ++ L  N ++ +P L+ 
Sbjct: 509 LSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLV- 567

Query: 278 RWTSLHLLYLGNTGLHRLRGS-FRCLVNLRFLDLSQNHLHHCPLQIC----ALKNLEVLG 332
               L +L L +  L RL  + F   +NLR+L+ S N L   P   C    +L  L++L 
Sbjct: 568 EHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLP-SACTGEESLSMLQLLY 626

Query: 333 LDDNKIGQ--LPSELGSLSKLKILGLTGNEFLSFPEEVLS-LASLEKLYIGQDQGFKLTY 389
           L +N +    +P  +G L  L+IL L  N+  +FP   L+ L  LE+L +    G KL  
Sbjct: 627 LTNNLLTDQCIPVLVGHL-HLRILHLANNQLQTFPASKLNKLEQLEELNL---SGNKLKT 682

Query: 390 VPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQ--LPDAICQAQALK 447
           +P  I   + L  L   +N++   P  L  +P ++ +D   N L +  +P+A+     L+
Sbjct: 683 IPTTIANCKRLHTLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEILIPEAL--PATLQ 739

Query: 448 ELRLEDN---LLTHLPENLDSLVNLKVLTLMDNPM 479
           +L L  N   +L H  + LD   ++  L +   P+
Sbjct: 740 DLDLTGNTNLVLEH--KTLDIFSHITTLKIDQKPL 772



 Score =  100 bits (250), Expect = 3e-21
 Identities = 97/342 (28%), Positives = 156/342 (45%), Gaps = 39/342 (11%)

Query: 165 TKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLP 224
           ++L+ + L  N+  +FP  LC + TL  ++L  N    +P +IG+L  LQ   +  N L 
Sbjct: 299 SQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLT 358

Query: 225 VLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLI------CR 278
            LP  L    QLS L +S N    IP+ + +L  +  + ++GN LE +   +       +
Sbjct: 359 TLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIK 418

Query: 279 WTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKI 338
              L + +L    +  L G+     ++  +DL  N L    L + +L +LE L    N++
Sbjct: 419 HVDLRMNHLKTMVIENLEGN----KHITHVDLRDNRL--TDLDLSSLCSLEQLHCGRNQL 472

Query: 339 GQLPSELGSL-------------------SKLKILGLTGNEFLSFPEEVLSLASLEKLYI 379
            +L     SL                   S L  L L+ N     P+       +E L +
Sbjct: 473 RELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDV 532

Query: 380 GQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDA 439
             +    LT VP  I    SL++L + +NH++ LP  +  +P LEVLD +HN L +LPD 
Sbjct: 533 SYN---LLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIP-LEVLDLQHNALTRLPDT 588

Query: 440 I-CQAQALKELRLEDNLLTHLPE---NLDSLVNLKVLTLMDN 477
           +  +A  L+ L    N L  LP      +SL  L++L L +N
Sbjct: 589 LFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNN 630



 Score = 95.9 bits (237), Expect = 9e-20
 Identities = 97/387 (25%), Positives = 181/387 (46%), Gaps = 40/387 (10%)

Query: 103 YNPIFSSSLVVVSFLHALRE-LRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEI 161
           Y+  FSS+       H   E L  YQ   ++   V+ + +  ++L   +   L+ +P+ +
Sbjct: 212 YSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRISTVDLSCYS---LEEVPEHL 268

Query: 162 VNQTKLREIYLKRNQFEVF-PQELCVLYT---LEIIDLDENKIGAIPEEIGHLTGLQKFY 217
                +  + L+ N  ++  P  L  LY    L+ ++L  NK+G  P  +  ++ L +  
Sbjct: 269 FYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELN 328

Query: 218 MASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLIC 277
           ++ N    LP+ +     L  L L  N L ++P+    L++++ +G+S N   ++P +  
Sbjct: 329 LSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYE 388

Query: 278 RWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNK 337
           + T L  + +    L         ++NL  L+   NH+ H  L++  LK + +  L+ NK
Sbjct: 389 KLTMLDRVVMAGNCLE--------VLNLGVLN-RMNHIKHVDLRMNHLKTMVIENLEGNK 439

Query: 338 IGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKL 397
                        +  + L  N       ++ SL SLE+L+ G++Q  +LT         
Sbjct: 440 ------------HITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLRELTLSGF----- 480

Query: 398 QSLKELYIENNHLEYLPVSLGSMPNL-EVLDCRHNLLKQLPDAICQAQALKELRLEDNLL 456
            SL+ LY  +N L    V++  +P+L   LD   NLL+ +PD  C+A+ ++ L +  NLL
Sbjct: 481 -SLRTLYASSNRLT--AVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLL 537

Query: 457 THLPENLDSLVNLKVLTLMDNPMEEPP 483
           T +P  + S ++L+ L L  N ++  P
Sbjct: 538 TEVPVRILSSLSLRKLMLGHNHVQNLP 564



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 135/493 (27%), Positives = 202/493 (40%), Gaps = 97/493 (19%)

Query: 16  QRNDPQHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRV 75
           QR   + V+ R   +D S  SL  +P  +F   ++  ++L +N ++     ++R   +  
Sbjct: 240 QRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQ-----LERPGGLDT 294

Query: 76  LYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPV 135
           LY                S L+ L+LS+N                 +L L+   L EI  
Sbjct: 295 LYK--------------FSQLKGLNLSHN-----------------KLGLFPILLCEIST 323

Query: 136 VIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDL 195
                   L  L L+ N    LP +I N   L+ + L  N     P+EL  L  L  + +
Sbjct: 324 --------LTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGI 375

Query: 196 DENKIGAIPEEIGHLTGLQKFYMASNNLPVLPAS-LCQCSQLSVLDLSHNLLHSIPKSFA 254
             N    IPE    LT L +  MA N L VL    L + + +  +DL  N L ++     
Sbjct: 376 SFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENL 435

Query: 255 ELRK-MTEIGLSGNRLE--------KVPRLICRWTSLHLLYLGNTGLHRLRGSFRCL--V 303
           E  K +T + L  NRL          + +L C    L  L L    L  L  S   L  V
Sbjct: 436 EGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAV 495

Query: 304 N-------LRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGL 356
           N       L FLDLS+N L   P   C  K +EVL +  N + ++               
Sbjct: 496 NVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEV--------------- 540

Query: 357 TGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVS 416
                   P  +LS  SL KL +G +    L  + EHI     L+ L +++N L  LP +
Sbjct: 541 --------PVRILSSLSLRKLMLGHNHVQNLPTLVEHI----PLEVLDLQHNALTRLPDT 588

Query: 417 LGSMP-NLEVLDCRHNLLKQLPDAICQAQALKELR---LEDNLLTH--LPENLDSLVNLK 470
           L S   NL  L+   N L+ LP A    ++L  L+   L +NLLT   +P  +  L +L+
Sbjct: 589 LFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHL-HLR 647

Query: 471 VLTLMDNPMEEPP 483
           +L L +N ++  P
Sbjct: 648 ILHLANNQLQTFP 660



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 74/244 (30%), Positives = 116/244 (47%), Gaps = 8/244 (3%)

Query: 29  FIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
           F+D S   L  +P       ++E + +  N + E+P  I    ++R L L  N++++L P
Sbjct: 506 FLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNL-P 564

Query: 89  ALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIF--KNLHHLEL 146
            L     LE LDL +N +      + S    LR L      L+ +P      ++L  L+L
Sbjct: 565 TLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQL 624

Query: 147 LGLTGNHL--KCLPKEIVNQTKLREIYLKRNQFEVFP-QELCVLYTLEIIDLDENKIGAI 203
           L LT N L  +C+P  +V    LR ++L  NQ + FP  +L  L  LE ++L  NK+  I
Sbjct: 625 LYLTNNLLTDQCIP-VLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTI 683

Query: 204 PEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIG 263
           P  I +   L      SNN+ + P  + Q  Q+  +DLS N L  I    A    + ++ 
Sbjct: 684 PTTIANCKRLHTLVAHSNNISIFP-EILQLPQIQFVDLSCNDLTEILIPEALPATLQDLD 742

Query: 264 LSGN 267
           L+GN
Sbjct: 743 LTGN 746



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 4/106 (3%)

Query: 385 FKLTYVPEHIRKLQSLKELYIENNHLEY-LPVSLGSM---PNLEVLDCRHNLLKQLPDAI 440
           + L  VPEH+   Q +  L + +N ++   P  L ++     L+ L+  HN L   P  +
Sbjct: 259 YSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILL 318

Query: 441 CQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486
           C+   L EL L  N    LP  + +L+NL+ L L  N +   P+E+
Sbjct: 319 CEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEEL 364



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 29/89 (32%), Positives = 40/89 (44%)

Query: 396 KLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNL 455
           K   LK L + +N L   P+ L  +  L  L+   N    LP  I     L+ L L+ N 
Sbjct: 297 KFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNF 356

Query: 456 LTHLPENLDSLVNLKVLTLMDNPMEEPPK 484
           LT LPE L +L  L  L +  N   + P+
Sbjct: 357 LTTLPEELGNLQQLSSLGISFNNFSQIPE 385


>gi|190014581 leucine rich repeat containing 2 [Homo sapiens]
          Length = 371

 Score =  102 bits (253), Expect = 1e-21
 Identities = 65/218 (29%), Positives = 105/218 (48%), Gaps = 24/218 (11%)

Query: 149 LTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIG 208
           L+G H   LP  +  QT LRE Y+     ++ P  + +   + I+DL +N+I  +P EIG
Sbjct: 105 LSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIG 164

Query: 209 HLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNL-LHSIPKSFAELRKMTEIGLSGN 267
            L  L++  +  N L  +P  L  C  L  LD S NL L  +P   + L+++T + +S N
Sbjct: 165 CLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISAN 224

Query: 268 RLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKN 327
           +   VP  + R                       + NL++LD+S N+L   P  I  L+ 
Sbjct: 225 KFSSVPICVLR-----------------------MSNLQWLDISSNNLTDLPQDIDRLEE 261

Query: 328 LEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFP 365
           L+   L  NK+  LP  + +L KL +L ++G+  +  P
Sbjct: 262 LQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELP 299



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 75/268 (27%), Positives = 128/268 (47%), Gaps = 29/268 (10%)

Query: 226 LPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLL 285
           LP    + S   V +LS      +P S  E   + E  +S   ++ +P  I  + ++ +L
Sbjct: 90  LPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRIL 149

Query: 286 YLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDN-KIGQLPSE 344
            L    +  L     CL NL+ L++  N+L   P ++   +NLE L    N ++ +LP E
Sbjct: 150 DLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209

Query: 345 LGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELY 404
           L +L ++  + ++ N+F S P  VL +++L+ L I  +    LT +P+ I +L+ L+   
Sbjct: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSN---NLTDLPQDIDRLEELQSFL 266

Query: 405 IENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLD 464
           +  N L YLP S+ ++  L +L    + L +LP A+C                      D
Sbjct: 267 LYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALC----------------------D 304

Query: 465 SLVNLKVLTLMDNPMEEPPKEVCAEGNE 492
           S   LK ++LMDNP++      C +GNE
Sbjct: 305 SSTPLKFVSLMDNPIDNAQ---CEDGNE 329



 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 67/256 (26%), Positives = 118/256 (46%), Gaps = 32/256 (12%)

Query: 5   IKSVEHSPKIHQRNDPQHVNDRT--FFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEE 62
           +  +E +    Q + P+    R+  F  + S +  T +P  +   T L E ++ N  I+ 
Sbjct: 76  LDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQI 135

Query: 63  IPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRE 122
           IP  IQ  + +R+L L KN +  L   +G L +L+ L++ +N                  
Sbjct: 136 IPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFN------------------ 177

Query: 123 LRLYQTDLKEIPVVIFKNLHHLELLGLTGN-HLKCLPKEIVNQTKLREIYLKRNQFEVFP 181
                  LK IP  +  +  +LE L  +GN  L  LP E+ N  ++  + +  N+F   P
Sbjct: 178 ------YLKSIPPEL-GDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVP 230

Query: 182 QELCVL--YTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVL 239
             +CVL    L+ +D+  N +  +P++I  L  LQ F +  N L  LP S+    +L++L
Sbjct: 231 --ICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLL 288

Query: 240 DLSHNLLHSIPKSFAE 255
            +S + L  +P +  +
Sbjct: 289 VVSGDHLVELPTALCD 304



 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 54/202 (26%), Positives = 91/202 (45%), Gaps = 24/202 (11%)

Query: 33  SNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGL 92
           SN  +  IP  I  F  +  + L  NQI  +P EI  LKN++ L +  N L+S+ P LG 
Sbjct: 129 SNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGD 188

Query: 93  LSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGN 152
             +LE LD S N                        +L E+P  +  NL  +  + ++ N
Sbjct: 189 CENLERLDCSGN-----------------------LELMELPFEL-SNLKQVTFVDISAN 224

Query: 153 HLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTG 212
               +P  ++  + L+ + +  N     PQ++  L  L+   L +NK+  +P  + +L  
Sbjct: 225 KFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKK 284

Query: 213 LQKFYMASNNLPVLPASLCQCS 234
           L    ++ ++L  LP +LC  S
Sbjct: 285 LTLLVVSGDHLVELPTALCDSS 306


>gi|27545328 leucine rich repeat containing 2 [Homo sapiens]
          Length = 371

 Score =  102 bits (253), Expect = 1e-21
 Identities = 65/218 (29%), Positives = 105/218 (48%), Gaps = 24/218 (11%)

Query: 149 LTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIG 208
           L+G H   LP  +  QT LRE Y+     ++ P  + +   + I+DL +N+I  +P EIG
Sbjct: 105 LSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIG 164

Query: 209 HLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNL-LHSIPKSFAELRKMTEIGLSGN 267
            L  L++  +  N L  +P  L  C  L  LD S NL L  +P   + L+++T + +S N
Sbjct: 165 CLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISAN 224

Query: 268 RLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKN 327
           +   VP  + R                       + NL++LD+S N+L   P  I  L+ 
Sbjct: 225 KFSSVPICVLR-----------------------MSNLQWLDISSNNLTDLPQDIDRLEE 261

Query: 328 LEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFP 365
           L+   L  NK+  LP  + +L KL +L ++G+  +  P
Sbjct: 262 LQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELP 299



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 75/268 (27%), Positives = 128/268 (47%), Gaps = 29/268 (10%)

Query: 226 LPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLL 285
           LP    + S   V +LS      +P S  E   + E  +S   ++ +P  I  + ++ +L
Sbjct: 90  LPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRIL 149

Query: 286 YLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDN-KIGQLPSE 344
            L    +  L     CL NL+ L++  N+L   P ++   +NLE L    N ++ +LP E
Sbjct: 150 DLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209

Query: 345 LGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELY 404
           L +L ++  + ++ N+F S P  VL +++L+ L I  +    LT +P+ I +L+ L+   
Sbjct: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSN---NLTDLPQDIDRLEELQSFL 266

Query: 405 IENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLD 464
           +  N L YLP S+ ++  L +L    + L +LP A+C                      D
Sbjct: 267 LYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALC----------------------D 304

Query: 465 SLVNLKVLTLMDNPMEEPPKEVCAEGNE 492
           S   LK ++LMDNP++      C +GNE
Sbjct: 305 SSTPLKFVSLMDNPIDNAQ---CEDGNE 329



 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 67/256 (26%), Positives = 118/256 (46%), Gaps = 32/256 (12%)

Query: 5   IKSVEHSPKIHQRNDPQHVNDRT--FFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEE 62
           +  +E +    Q + P+    R+  F  + S +  T +P  +   T L E ++ N  I+ 
Sbjct: 76  LDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQI 135

Query: 63  IPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRE 122
           IP  IQ  + +R+L L KN +  L   +G L +L+ L++ +N                  
Sbjct: 136 IPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFN------------------ 177

Query: 123 LRLYQTDLKEIPVVIFKNLHHLELLGLTGN-HLKCLPKEIVNQTKLREIYLKRNQFEVFP 181
                  LK IP  +  +  +LE L  +GN  L  LP E+ N  ++  + +  N+F   P
Sbjct: 178 ------YLKSIPPEL-GDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVP 230

Query: 182 QELCVL--YTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVL 239
             +CVL    L+ +D+  N +  +P++I  L  LQ F +  N L  LP S+    +L++L
Sbjct: 231 --ICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLL 288

Query: 240 DLSHNLLHSIPKSFAE 255
            +S + L  +P +  +
Sbjct: 289 VVSGDHLVELPTALCD 304



 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 54/202 (26%), Positives = 91/202 (45%), Gaps = 24/202 (11%)

Query: 33  SNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGL 92
           SN  +  IP  I  F  +  + L  NQI  +P EI  LKN++ L +  N L+S+ P LG 
Sbjct: 129 SNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGD 188

Query: 93  LSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGN 152
             +LE LD S N                        +L E+P  +  NL  +  + ++ N
Sbjct: 189 CENLERLDCSGN-----------------------LELMELPFEL-SNLKQVTFVDISAN 224

Query: 153 HLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTG 212
               +P  ++  + L+ + +  N     PQ++  L  L+   L +NK+  +P  + +L  
Sbjct: 225 KFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKK 284

Query: 213 LQKFYMASNNLPVLPASLCQCS 234
           L    ++ ++L  LP +LC  S
Sbjct: 285 LTLLVVSGDHLVELPTALCDSS 306


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.138    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,966,861
Number of Sequences: 37866
Number of extensions: 1016106
Number of successful extensions: 7281
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 191
Number of HSP's successfully gapped in prelim test: 112
Number of HSP's that attempted gapping in prelim test: 3622
Number of HSP's gapped (non-prelim): 1474
length of query: 560
length of database: 18,247,518
effective HSP length: 107
effective length of query: 453
effective length of database: 14,195,856
effective search space: 6430722768
effective search space used: 6430722768
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.