Search of human proteins with 122937247

Search of human proteins with 122937247

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|122937247 unc-13 homolog A [Homo sapiens]
         (1791 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122937247 unc-13 homolog A [Homo sapiens]                         3638   0.0  
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]                  2461   0.0  
gi|122937514 unc-13 homolog C [Homo sapiens]                         1841   0.0  
gi|46195765 unc-13 homolog D [Homo sapiens]                            99   3e-20
gi|15451914 BAI1-associated protein 3 [Homo sapiens]                   93   3e-18
gi|13384594 protein kinase C, gamma [Homo sapiens]                     82   4e-15
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]            79   4e-14
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]            79   4e-14
gi|4506067 protein kinase C, alpha [Homo sapiens]                      79   5e-14
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi...    74   1e-12
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi...    74   1e-12
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg...    73   2e-12
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu...    73   2e-12
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul...    73   2e-12
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo...    69   3e-11
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom...    69   3e-11
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]    69   4e-11
gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi...    69   4e-11
gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapi...    69   4e-11
gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi...    69   4e-11
gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapi...    69   4e-11
gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapi...    69   4e-11
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi...    69   4e-11
gi|148839284 Ca2+-dependent activator protein for secretion 2 is...    65   8e-10
gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Hom...    64   1e-09
gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Hom...    64   1e-09
gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Hom...    64   1e-09
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]              63   2e-09
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]             63   2e-09
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]             63   2e-09

>gi|122937247 unc-13 homolog A [Homo sapiens]
          Length = 1791

 Score = 3638 bits (9435), Expect = 0.0
 Identities = 1791/1791 (100%), Positives = 1791/1791 (100%)

Query: 1    MGGGGTCTISVQVRVCTGGNLLGGRRRPLSPCNEEVWGEAPLPGARPFNAPPARSAPAPS 60
            MGGGGTCTISVQVRVCTGGNLLGGRRRPLSPCNEEVWGEAPLPGARPFNAPPARSAPAPS
Sbjct: 1    MGGGGTCTISVQVRVCTGGNLLGGRRRPLSPCNEEVWGEAPLPGARPFNAPPARSAPAPS 60

Query: 61   GVPGLRLPAPHQRHSRPGRLRPTCELGDMSLLCVGVKKAKFDGAQEKFNTYVTLKVQNVK 120
            GVPGLRLPAPHQRHSRPGRLRPTCELGDMSLLCVGVKKAKFDGAQEKFNTYVTLKVQNVK
Sbjct: 61   GVPGLRLPAPHQRHSRPGRLRPTCELGDMSLLCVGVKKAKFDGAQEKFNTYVTLKVQNVK 120

Query: 121  STTIAVRGSQPSWEQDFMFEINRLDLGLTVEVWNKGLIWDTMVGTVWIPLRTIRQSNEEG 180
            STTIAVRGSQPSWEQDFMFEINRLDLGLTVEVWNKGLIWDTMVGTVWIPLRTIRQSNEEG
Sbjct: 121  STTIAVRGSQPSWEQDFMFEINRLDLGLTVEVWNKGLIWDTMVGTVWIPLRTIRQSNEEG 180

Query: 181  PGEWLTLDSQVIMADSEICGTKDPTFHRILLDTRFELPLDIPEEEARYWAKKLEQLNAMR 240
            PGEWLTLDSQVIMADSEICGTKDPTFHRILLDTRFELPLDIPEEEARYWAKKLEQLNAMR
Sbjct: 181  PGEWLTLDSQVIMADSEICGTKDPTFHRILLDTRFELPLDIPEEEARYWAKKLEQLNAMR 240

Query: 241  DQDEYSFQDEQDKPLPVPSNQCCNWNYFGWGEQHNDDPDSAVDDRDSDYRSETSNSIPPP 300
            DQDEYSFQDEQDKPLPVPSNQCCNWNYFGWGEQHNDDPDSAVDDRDSDYRSETSNSIPPP
Sbjct: 241  DQDEYSFQDEQDKPLPVPSNQCCNWNYFGWGEQHNDDPDSAVDDRDSDYRSETSNSIPPP 300

Query: 301  YYTTSQPNASVHQYSVRPPPLGSRESYSDSMHSYEEFSEPQALSPTGSSRYASSGELSQG 360
            YYTTSQPNASVHQYSVRPPPLGSRESYSDSMHSYEEFSEPQALSPTGSSRYASSGELSQG
Sbjct: 301  YYTTSQPNASVHQYSVRPPPLGSRESYSDSMHSYEEFSEPQALSPTGSSRYASSGELSQG 360

Query: 361  SSQLSEDFDPDEHSLQGSDMEDERDRDSYHSCHSSVSYHKDSPRWDQDEEELEEDLEDFL 420
            SSQLSEDFDPDEHSLQGSDMEDERDRDSYHSCHSSVSYHKDSPRWDQDEEELEEDLEDFL
Sbjct: 361  SSQLSEDFDPDEHSLQGSDMEDERDRDSYHSCHSSVSYHKDSPRWDQDEEELEEDLEDFL 420

Query: 421  EEEELPEDEEELEEEEEEVPDDLGSYAQREDVAVAEPKDFKRISLPPAAPGKEDKAPVAP 480
            EEEELPEDEEELEEEEEEVPDDLGSYAQREDVAVAEPKDFKRISLPPAAPGKEDKAPVAP
Sbjct: 421  EEEELPEDEEELEEEEEEVPDDLGSYAQREDVAVAEPKDFKRISLPPAAPGKEDKAPVAP 480

Query: 481  TEAPDMAKVAPKPATPDKVPAAEQIPEAEPPKDEESFRPREDEEGQEGQDSMSRAKANWL 540
            TEAPDMAKVAPKPATPDKVPAAEQIPEAEPPKDEESFRPREDEEGQEGQDSMSRAKANWL
Sbjct: 481  TEAPDMAKVAPKPATPDKVPAAEQIPEAEPPKDEESFRPREDEEGQEGQDSMSRAKANWL 540

Query: 541  RAFNKVRMQLQEARGEGEMSKSLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAMSLVQ 600
            RAFNKVRMQLQEARGEGEMSKSLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAMSLVQ
Sbjct: 541  RAFNKVRMQLQEARGEGEMSKSLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAMSLVQ 600

Query: 601  SRKAGITSALASSTLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEG 660
            SRKAGITSALASSTLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEG
Sbjct: 601  SRKAGITSALASSTLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEG 660

Query: 661  LLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMK 720
            LLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMK
Sbjct: 661  LLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMK 720

Query: 721  IRERNKPEIFELIQEIFAVTKTAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKD 780
            IRERNKPEIFELIQEIFAVTKTAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKD
Sbjct: 721  IRERNKPEIFELIQEIFAVTKTAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKD 780

Query: 781  KTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSR 840
            KTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSR
Sbjct: 781  KTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSR 840

Query: 841  VKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKV 900
            VKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKV
Sbjct: 841  VKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKV 900

Query: 901  APYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVE 960
            APYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVE
Sbjct: 901  APYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVE 960

Query: 961  SIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKER 1020
            SIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKER
Sbjct: 961  SIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKER 1020

Query: 1021 FVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRA 1080
            FVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRA
Sbjct: 1021 FVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRA 1080

Query: 1081 SQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDFWSKLI 1140
            SQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDFWSKLI
Sbjct: 1081 SQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDFWSKLI 1140

Query: 1141 TLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSAD 1200
            TLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSAD
Sbjct: 1141 TLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSAD 1200

Query: 1201 YMNLHFKVKWLYNEYVTELPAFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDK 1260
            YMNLHFKVKWLYNEYVTELPAFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDK
Sbjct: 1201 YMNLHFKVKWLYNEYVTELPAFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDK 1260

Query: 1261 KDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQY 1320
            KDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQY
Sbjct: 1261 KDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQY 1320

Query: 1321 ADIISKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVK 1380
            ADIISKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVK
Sbjct: 1321 ADIISKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVK 1380

Query: 1381 LNNVLDELSRVFATSFQPHIEECVKQMGDILSQVKGTGNVPASACSSVAQDADNVLQPIM 1440
            LNNVLDELSRVFATSFQPHIEECVKQMGDILSQVKGTGNVPASACSSVAQDADNVLQPIM
Sbjct: 1381 LNNVLDELSRVFATSFQPHIEECVKQMGDILSQVKGTGNVPASACSSVAQDADNVLQPIM 1440

Query: 1441 DLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGNLLRKHGKGL 1500
            DLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGNLLRKHGKGL
Sbjct: 1441 DLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGNLLRKHGKGL 1500

Query: 1501 EKGRVKLPSHSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQY 1560
            EKGRVKLPSHSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQY
Sbjct: 1501 EKGRVKLPSHSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQY 1560

Query: 1561 FHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQGLGVEDPVGEVSV 1620
            FHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQGLGVEDPVGEVSV
Sbjct: 1561 FHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQGLGVEDPVGEVSV 1620

Query: 1621 HVELFTHPGTGEHKVTVKVVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNN 1680
            HVELFTHPGTGEHKVTVKVVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNN
Sbjct: 1621 HVELFTHPGTGEHKVTVKVVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNN 1680

Query: 1681 SWAPKYNESFQFTLSADAGPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACW 1740
            SWAPKYNESFQFTLSADAGPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACW
Sbjct: 1681 SWAPKYNESFQFTLSADAGPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACW 1740

Query: 1741 LPLGRRIHMDDTGLTVLRILSQRSNDEVAKEFVKLKSDTRSAEEGGAAPAP 1791
            LPLGRRIHMDDTGLTVLRILSQRSNDEVAKEFVKLKSDTRSAEEGGAAPAP
Sbjct: 1741 LPLGRRIHMDDTGLTVLRILSQRSNDEVAKEFVKLKSDTRSAEEGGAAPAP 1791


>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
          Length = 1591

 Score = 2461 bits (6378), Expect = 0.0
 Identities = 1251/1707 (73%), Positives = 1398/1707 (81%), Gaps = 127/1707 (7%)

Query: 89   MSLLCVGVKKAKFDGAQEKFNTYVTLKVQNVKSTTIAVRGSQPSWEQDFMFEINRLDLGL 148
            MSLLCV VK+AKF G+ +KFNTYVTLKVQNVKSTT+AVRG QPSWEQDFMFEI+RLDLGL
Sbjct: 1    MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGL 60

Query: 149  TVEVWNKGLIWDTMVGTVWIPLRTIRQSNEEGPGEWLTLDSQVIMADSEICGTKDPTFHR 208
            +VEVWNKGLIWDTMVGTVWI L+TIRQS+EEGPGEW TL+++ +M D EICGT++PT H+
Sbjct: 61   SVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTRNPTPHK 120

Query: 209  ILLDTRFELPLDIPEEEARYWAKKLEQLNAMRDQDEYSFQDE-QDKPLPVPSNQCCNWNY 267
            ILLDTRFELP DIPEEEARYW  K EQ+NA+   +EYS Q+E Q KPLP  + QC     
Sbjct: 121  ILLDTRFELPFDIPEEEARYWTYKWEQINALGADNEYSSQEESQRKPLPTAAAQCSF--- 177

Query: 268  FGWGEQHNDDPDSAVDDRDSDYRSETSNSIPPPYYTTSQPNASVHQYSV---RPPPL--- 321
                    +DPDSAVDDRDSDYRSETSNS PPPY+T SQPNASVHQ+ V    P  L   
Sbjct: 178  --------EDPDSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQ 229

Query: 322  -GSRESYSDSMHSYE-EFSEPQALSPTGSSRYASSGELSQGSSQLSEDFDPDEHSLQGSD 379
              SR+S +DSM SY+ ++ E +A+SPT SSRY SS  +SQGSSQLSE    D++  Q   
Sbjct: 230  GSSRDSCNDSMQSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSE---LDQYHEQD-- 284

Query: 380  MEDERDRDSYHSCHSSVSYHKDSPRWDQDEEELEEDLEDFLEEEELPEDEEELEEEEEEV 439
             +D R+ DS HSCHSS S  +D                             +    E+E 
Sbjct: 285  -DDHRETDSIHSCHSSHSLSRDG----------------------------QAGFGEQEK 315

Query: 440  PDDLGSYAQREDVAVAEPKDFKRISLPPAAPGKEDKAPVAPTEAPDMAKVAPKPATPDKV 499
            P ++   A++E  A  EPK+ K           ED    A T  P           PD V
Sbjct: 316  PLEVTGQAEKE--AACEPKEMK-----------ED----ATTHPP-----------PDLV 347

Query: 500  PAAEQIPEAEPPKDEESFRPREDEEGQEGQDSMSRAKANWLRAFNKVRMQLQEARGEGEM 559
               +               P+E    +      ++A+A+W+RA  KVR+QLQE   +G+ 
Sbjct: 348  LQKDHF-----------LGPQESFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDP 396

Query: 560  SKSLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAMSLVQSRKAGITSALASST-LNNE 618
            S   W   GP GGL  IDSMPD+R++KP+PLVSDL  SLVQSRKAGITSA+A+ T L +E
Sbjct: 397  SLPQWLPEGPAGGLYGIDSMPDLRRKKPLPLVSDL--SLVQSRKAGITSAMATRTSLKDE 454

Query: 619  ELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVK 678
            ELK+HVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRC+ECGVK
Sbjct: 455  ELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVK 514

Query: 679  CHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFELIQEIFA 738
            CHEKCQDLLNADCLQRAAEKS KHGAEDRTQNIIM +KDRMKIRERNKPEIFE+I+++F 
Sbjct: 515  CHEKCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFT 574

Query: 739  VTKTAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKK 798
            V K AH QQMK VKQSVLDGTSKWSAKI+ITVVCAQGLQAKDKTGSSDPYVTVQV KTKK
Sbjct: 575  VNKAAHVQQMKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKK 634

Query: 799  RTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTII 858
            RTKTI+GNLNPVWEE FHFECHNSSDRIKVRVWDEDDDIKSRVKQR KRESDDFLGQTII
Sbjct: 635  RTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTII 694

Query: 859  EVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFV 918
            EVRTLSGEMDVWYNL+KRTDKSAVSGAIRL ISVEIKGEEKVAPYHVQYTCLHENLFH++
Sbjct: 695  EVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYL 754

Query: 919  TDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVESIYQAMTHFACLSSKYMC 978
            TD+Q +G V+IP+A+GDDAWKVY+DETAQEIVDEFAMRYG+ESIYQAMTHFACLSSKYMC
Sbjct: 755  TDIQGSGGVRIPEARGDDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMC 814

Query: 979  PGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSM 1038
            PGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLS 
Sbjct: 815  PGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLST 874

Query: 1039 YRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEY 1098
            YRNNFPA SPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEY
Sbjct: 875  YRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEY 934

Query: 1099 IFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDFWSKLITLIVSIIEEDKNSYTPCL 1158
            IFNNCH+LYSR+YQ     K E+ PEEQGPSI+NLDFW KLITLIVSIIEEDKNSYTP L
Sbjct: 935  IFNNCHDLYSRQYQL----KQELPPEEQGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVL 990

Query: 1159 NQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVTE 1218
            NQFPQELNVGK+SAEVMW+LFAQDMKYA+EEH+K  LCKSADYMNLHFKVKWL+NEYV +
Sbjct: 991  NQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHNEYVRD 1050

Query: 1219 LPAFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVV 1278
            LP  + +VPEYPAWFE FV+QWLDENE+VS +FL GALERDKKDGFQQTSEHALFSCSVV
Sbjct: 1051 LPVLQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVV 1110

Query: 1279 DVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQYADIISKDFASYCSKEKEK 1338
            DVF+QLNQSFEII+KLECPDP I+ HYMRRFAKTI  VL+QYADI+SKDF +YC+  KEK
Sbjct: 1111 DVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGKVLMQYADILSKDFPAYCT--KEK 1168

Query: 1339 VPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELSRVFATSFQP 1398
            +PCILMNN QQLRVQLEKMFEAMGGKELD EA+D LKELQVKLN VLDELS VF  SFQ 
Sbjct: 1169 LPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNSFQV 1228

Query: 1399 HIEECVKQMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTV 1458
             I+ECV+QM DIL QV+GTGN    A +S AQDAD+VL+P+MD LD NLTLFA +CEKTV
Sbjct: 1229 RIDECVRQMADILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCEKTV 1288

Query: 1459 LKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGNLLRKHGKGLEKGRVKLPSHSDGTQMIF 1518
            LKRVLKELW++VMNTME+ IVLPPLTDQT                         GTQ+IF
Sbjct: 1289 LKRVLKELWRVVMNTMERMIVLPPLTDQT-------------------------GTQLIF 1323

Query: 1519 NAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPD 1578
             AAKEL  LSKLKDHMVREE ++LTPKQCAV++LALDTIKQYFHAGG GLKKTFLEKSPD
Sbjct: 1324 TAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPD 1383

Query: 1579 LQSLRYALSLYTQATDLLIKTFVQTQSAQGLGVEDPVGEVSVHVELFTHPGTGEHKVTVK 1638
            LQSLRYALSLYTQ TD LIKTFV++Q+ QG GV+DPVGEVS+ V+LFTHPGTGEHKVTVK
Sbjct: 1384 LQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEHKVTVK 1443

Query: 1639 VVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNNSWAPKYNESFQFTLSADA 1698
            VVAANDLKWQT+G+FRPF+EV ++GP  SDKKRKF TKSK+N+WAPKYNE+F F L  + 
Sbjct: 1444 VVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLGNEE 1503

Query: 1699 GPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLR 1758
            GPE YELQ+CVKDYCFAREDR +GLAV+ LR++  +GS ACW PLGR+IHMD+TGLT+LR
Sbjct: 1504 GPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILR 1563

Query: 1759 ILSQRSNDEVAKEFVKLKSDTRSAEEG 1785
            ILSQRSNDEVA+EFVKLKS++RS EEG
Sbjct: 1564 ILSQRSNDEVAREFVKLKSESRSTEEG 1590


>gi|122937514 unc-13 homolog C [Homo sapiens]
          Length = 2214

 Score = 1841 bits (4769), Expect = 0.0
 Identities = 972/1595 (60%), Positives = 1176/1595 (73%), Gaps = 91/1595 (5%)

Query: 215  FELPLDIPEEEARYWAKKLEQLNAMRDQDEYSF-QDEQDKPLPVPSNQCCNWNYFGWGEQ 273
            F+  LD+  ++  Y  K    L    D + Y   QD+   P P   N+        W  Q
Sbjct: 684  FDQQLDVYNKDLEYLGKCHSDLQD--DSESYDLTQDDNSSPCPGLDNEPQGQ----WVGQ 737

Query: 274  HNDDPDSAVDDRDSDYRSETSNSIPPPYYTTSQPNASVHQYSVRPPPLGSRESYSDSMHS 333
            ++     +    +S+   +  N +   Y + S+  +   + +   PP       S  + S
Sbjct: 738  YD-----SYQGANSNELYQNQNQLSMMYRSQSELQSDDSEDA---PPKSWHSRLSIDL-S 788

Query: 334  YEEFSEPQALSPTGSSRYASSGELSQGSSQLSEDFDPDEHSLQGSDMEDERDRDSYHSCH 393
             + FS P+  S    ++ A     ++ +  LS  ++    SL G      R R    S  
Sbjct: 789  DKTFSFPKFGSTLQRAKSALEVVWNKSTQSLS-GYEDSGSSLMG------RFRTLSQSTA 841

Query: 394  SSVSYHKDSPRWDQDEEELEEDLEDFLEEEELPEDEEELEEEEEEVPDDLGSYAQREDVA 453
            +  S   DS  + +      ED ED+ E   + ++E +  E  E+V   L     R  + 
Sbjct: 842  NESSTTLDSDVYTEPYYYKAEDEEDYTEP--VADNETDYVEVMEQV---LAKLENRTSIT 896

Query: 454  VAEPK--DFKRISLPPAAPGKEDKAPVAPTEAPDMAKVAPKPATPDKVPAAEQIPEAEPP 511
              + +   +  +S        +D+    P  A DM       +     P  E   E E  
Sbjct: 897  ETDEQMQAYDHLSYETPYETPQDEGYDGP--ADDMV------SEEGLEPLNETSAEMEIR 948

Query: 512  KDEESFRPREDEEGQEGQDSMSRAKANWLRAFNKVRMQLQEARGEGEMSK---------- 561
            +DE    P +  E  + +      K   LRA+ K   +L+E    G+ S           
Sbjct: 949  EDENQNIPEQPVEITKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSSVDEKARIVSG 1008

Query: 562  ---------SLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAMSLVQSRKAGITSALAS 612
                     +L   GG GGGL  IDSMPD+R++K +P+V D+AM+L  +RK+G++ A+  
Sbjct: 1009 NDLDASKFSALQVCGGAGGGLYGIDSMPDLRRKKTLPIVRDVAMTLA-ARKSGLSLAMVI 1067

Query: 613  ST-LNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 671
             T LNNEELK HV+KKTLQALIYP+S T PHNFEVWTATTPTYCYECEGLLWGIARQGM+
Sbjct: 1068 RTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMK 1127

Query: 672  CTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFE 731
            C ECGVKCHEKCQDLLNADCLQRAAEKSSKHGAED+TQ II  +K+RMKIRE+N+PE+FE
Sbjct: 1128 CLECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIREKNRPEVFE 1187

Query: 732  LIQEIFAVTKTAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDPYVTV 791
            +IQE+F ++K    Q  KA KQSVLDGTSKWSAKI+ITVV AQGLQAKDKTGSSDPYVTV
Sbjct: 1188 VIQEMFQISKEDFVQFTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTV 1247

Query: 792  QVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDD 851
            QVGK K+RTKTI+GNLNPVW+E F+FECHNS+DRIKVRVWDEDDDIKSRVKQ FK+ESDD
Sbjct: 1248 QVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDD 1307

Query: 852  FLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLH 911
            FLGQTI+EVRTLSGEMDVWYNL+KRTDKSAVSGAIRL I+VEIKGEEKVAPYH+QYTCLH
Sbjct: 1308 FLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLH 1367

Query: 912  ENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVESIYQAMTHFAC 971
            ENLFH++T+V++NG VKIP+ KGD+AWKV++D+ +QEIVDEFAMRYG+ESIYQAMTHF+C
Sbjct: 1368 ENLFHYLTEVKSNGGVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSC 1427

Query: 972  LSSKYMCPGVPAVMSTLLANINAYYAHTTASTN--VSASDRFAASNFGKERFVKLLDQLH 1029
            LSSKYMCPGVPAVMSTLLANINA+YAHTT STN  VSASDRFAA+NFG+E+F+KLLDQLH
Sbjct: 1428 LSSKYMCPGVPAVMSTLLANINAFYAHTTVSTNIQVSASDRFAATNFGREKFIKLLDQLH 1487

Query: 1030 NSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVK 1089
            NSLRIDLS YR NFPAS+ ERLQDLKSTVDLLTSITFFRMKV ELQSPP+AS VVKDCV+
Sbjct: 1488 NSLRIDLSKYRENFPASNTERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVR 1547

Query: 1090 ACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDFWSKLITLIVSIIEE 1149
            ACL+STY+YIF+NCHELYS+   TDP+KK ++  E+QGP+ KNLDFW +LITL+V+II+E
Sbjct: 1548 ACLDSTYKYIFDNCHELYSQ--LTDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDE 1605

Query: 1150 DKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVK 1209
            DK +YTP LNQFPQELN+GKISAE+MW LFA DMKYA+EEH+  RLCKS DYMNLHFKVK
Sbjct: 1606 DKTAYTPVLNQFPQELNMGKISAEIMWTLFALDMKYALEEHENQRLCKSTDYMNLHFKVK 1665

Query: 1210 WLYNEYVTELPAFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSE 1269
            W YNEYV ELPAFKD VPEY  WFEPFV+QWLDENE+VS +FLHGAL RDKKDGFQQTSE
Sbjct: 1666 WFYNEYVRELPAFKDAVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSE 1725

Query: 1270 HALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQYADIISKDFA 1329
            HALFSCSVVDVF+QLNQSFEIIKKLECP+P+ + H MRRFAKTI+ VLLQYA I+S DF+
Sbjct: 1726 HALFSCSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFS 1785

Query: 1330 SYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELS 1389
            S+C  +KE VPCILMNN QQLRVQLEKMFE+MGGKELD+EAS ILKELQVKL+ VLDELS
Sbjct: 1786 SHC--DKENVPCILMNNIQQLRVQLEKMFESMGGKELDSEASTILKELQVKLSGVLDELS 1843

Query: 1390 RVFATSFQPHIEECVKQMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTL 1449
              +  SFQ  IEEC+KQM   L+Q++  GN  ++  +S A DA+ VL+ +MD LD  L+L
Sbjct: 1844 VTYGESFQVIIEECIKQMSFELNQMRANGNTTSNK-NSAAMDAEIVLRSLMDFLDKTLSL 1902

Query: 1450 FAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGNLLRKHGKGLEKGRVKLPS 1509
             AKICEKTVLKRVLKELWKLV+N +EK IVLPPLTDQT                      
Sbjct: 1903 SAKICEKTVLKRVLKELWKLVLNKIEKQIVLPPLTDQT---------------------- 1940

Query: 1510 HSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLK 1569
               G QMIF AAK+LGQLSKLK+HM+RE+A+ LTP+QCA++E+ L TIKQYFHAGG GLK
Sbjct: 1941 ---GPQMIFIAAKDLGQLSKLKEHMIREDARGLTPRQCAIMEVVLATIKQYFHAGGNGLK 1997

Query: 1570 KTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQGLGVEDPVGEVSVHVELFTHPG 1629
            K FLEKSPDLQSLRYALSLYTQ TD LIK F+ TQ++Q    +D VG++SVHV++   PG
Sbjct: 1998 KNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRSSKDAVGQISVHVDITATPG 2057

Query: 1630 TGEHKVTVKVVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNNSWAPKYNES 1689
            TG+HKVTVKV+A NDL WQT+ +FRPF+EV I+GP L DKKRK  TK+K+N+W+PKYNE+
Sbjct: 2058 TGDHKVTVKVIAINDLNWQTTAMFRPFVEVCILGPNLGDKKRKQGTKTKSNTWSPKYNET 2117

Query: 1690 FQFTLSADAGPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHM 1749
            FQF L  +  P  YEL + VKDYCFAREDR +G+ V+QL+ +A++GS   W PL + I M
Sbjct: 2118 FQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEKGSYGAWYPLLKNISM 2177

Query: 1750 DDTGLTVLRILSQRSNDEVAKEFVKLKSDTRSAEE 1784
            D+TGLT+LRILSQR++D+VAKEFV+LKS+TRS EE
Sbjct: 2178 DETGLTILRILSQRTSDDVAKEFVRLKSETRSTEE 2212


>gi|46195765 unc-13 homolog D [Homo sapiens]
          Length = 1090

 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 233/1149 (20%), Positives = 420/1149 (36%), Gaps = 223/1149 (19%)

Query: 728  EIFELIQEIFAVTKTAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDP 787
            E+   +QE F V    H Q ++ V++       K    +  TV  A+G+  KD +G SDP
Sbjct: 80   ELLRYLQEAFHVEPEEHQQTLQRVRE-----LEKPIFCLKATVKQAKGILGKDVSGFSDP 134

Query: 788  YVTVQV--------------------------GKTKKRTKTIYGNLNPVWEENFHFECHN 821
            Y  + +                           +   RT+ I   LNPVW+E F  E  +
Sbjct: 135  YCLLGIEQGVGVPGGSPGSRHRQKAVVRHTIPEEETHRTQVITQTLNPVWDETFILEFED 194

Query: 822  -SSDRIKVRVWDED--DDIKSRV--------------KQRFKRESDDFLGQTIIEVRTLS 864
             ++    + +WD D  + ++ ++              + R  +  DDFLG  ++ ++ L 
Sbjct: 195  ITNASFHLDMWDLDTVESVRQKLGELTDLHGLRRIFKEARKDKGQDDFLGNVVLRLQDLR 254

Query: 865  GEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVA-----PYHVQYTCLHENLFHFVT 919
               D WY L+ RT+     G   L   +  K     A      Y V    L + + H VT
Sbjct: 255  CREDQWYPLEPRTETYPDRGQCHLQFQLIHKRRATSASRSQPSYTVHLHLLQQLVSHEVT 314

Query: 920  DVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVESIYQAMTHFACLSSKYMCP 979
              +           G  +W       A  ++   A +  +   +Q+M  +   S  Y   
Sbjct: 315  QHE----------AGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMAQWLAYSRLYQSL 364

Query: 980  GVPAVMSTLLANINAY-YAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSM 1038
              P+  S LL  I +  Y            +  AAS      F  LL    + +R     
Sbjct: 365  EFPS--SCLLHPITSIEYQWIQGRLKAEQQEELAAS------FSSLLTYGLSLIR----R 412

Query: 1039 YRNNFPAS---SPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNST 1095
            +R+ FP S   SP RLQ L             R+ VQ  +        +K   + C N+ 
Sbjct: 413  FRSVFPLSVSDSPARLQSL------------LRVLVQMCK--------MKAFGELCPNTA 452

Query: 1096 YEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDFWSK-LITLIVSIIEEDKNSY 1154
                     +L +   QT   +   +  +   P ++ +    K L+ L+  +I +     
Sbjct: 453  ------PLPQLVTEALQTGTTEWFHLKQQHHQPMVQGIPEAGKALLGLVQDVIGDLHQCQ 506

Query: 1155 TPCLNQFPQELNVGKIS---AEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWL 1211
                  F   L +   S    E+ W +  +   +     D            L+  +K L
Sbjct: 507  RTWDKIFHNTLKIHLFSMAFRELQWLVAKRVQDHTTVVGDVVSPEMGESLFQLYISLKEL 566

Query: 1212 YNEYVTELPAFKDRV---PEYPAWFEPFVIQWLDE--NEEVSRDFLHGALERDKKDGFQQ 1266
                ++   + +D V     +  WF+P +  WL +  NE ++R  +  A++ D+     +
Sbjct: 567  CQLRMSS--SERDGVLALDNFHRWFQPAIPSWLQKTYNEALAR--VQRAVQMDELVPLGE 622

Query: 1267 TSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQYADIISK 1326
             ++H   S S VD+ +   Q     ++L+ PDP+       +F +    + L Y  +I  
Sbjct: 623  LTKH---STSAVDLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKA 679

Query: 1327 DFASYCSKEKEK-----VPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKE----- 1376
                  S +K++     + C+++N+ +QLR+ + K+   +  + L+     +L++     
Sbjct: 680  RARELSSGQKDQGQAANMLCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGAVLEQGQLQN 739

Query: 1377 -LQVKLNNVLDELSRVFATSFQPHIEECVKQMGDILSQVKGTGNVPASACSSVAQDADNV 1435
             L  +L + L  L     T  +   E+    +   + ++ G         S + +DA   
Sbjct: 740  TLHAQLQSALAGLGHEIRTGVRTLAEQLEVGIAKHIQKLVGVRE------SVLPEDA--- 790

Query: 1436 LQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGNLLRK 1495
            + P+M  L+  L        +     +L  LW     T   T+++     Q         
Sbjct: 791  ILPLMKFLEVELCYMNTNLVQENFSSLLTLLW-----THTLTVLVEAAASQ--------- 836

Query: 1496 HGKGLEKGRVKLPSHSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALD 1555
                L   R+K+   +   ++ F+A                 E   L PK       AL 
Sbjct: 837  RSSSLASNRLKIALQN--LEICFHA-----------------EGCGLPPK-------ALH 870

Query: 1556 TIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQGLGVEDPV 1615
            T    F A         L++  +LQ+          + +L+ K F      Q     + +
Sbjct: 871  TAT--FQA---------LQRDLELQA--------ASSRELIRKYFCSRIQQQAETTSEEL 911

Query: 1616 GEVSVHVELFTHPGTGEHKVTVKVVAAND-LKWQTSGIFRPFIEVNIIGPQLSDKKRKFA 1674
            G V+V           E K+ V++++A+  L   ++G   PF+++ +       +     
Sbjct: 912  GAVTVKASY----RASEQKLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARE 967

Query: 1675 TKSKNNSWAPKYNESFQFTLSADAGPECYELQVC----VKDYCFAREDRTVGLAVLQLRE 1730
            T+       P ++E+F+F + A+    C +   C    V DY     D   G A L LRE
Sbjct: 968  TQKHKKDLHPLFDETFEFLVPAE---PCRKAGACLLLTVLDYDTLGADDLEGEAFLPLRE 1024

Query: 1731 LAQRGSA-------ACWLPLGRRIHMDDTGLTVLRILSQRSNDEVAKEFVKLKSD-TRSA 1782
            +     +          LPL    +    G  +L++L  R  D  A+ FV+L+    + A
Sbjct: 1025 VPGLSGSEEPGEVPQTRLPL---TYPAPNGDPILQLLEGRKGDREAQVFVRLRRHRAKQA 1081

Query: 1783 EEGGAAPAP 1791
             +    PAP
Sbjct: 1082 SQHALRPAP 1090


>gi|15451914 BAI1-associated protein 3 [Homo sapiens]
          Length = 1187

 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 168/832 (20%), Positives = 310/832 (37%), Gaps = 153/832 (18%)

Query: 729  IFELIQEIFAVTKTAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDPY 788
            +   +Q++F  +   HT+ ++ V+++        +  + ++V+ A+ L AKD  G SDPY
Sbjct: 165  LLSYLQQVFGTSLEEHTEAIERVRKAKAP-----TYALKVSVMRAKNLLAKDPNGFSDPY 219

Query: 789  VTVQV--------------------GKTKKR-----------TKTIYGNLNPVWEENFHF 817
              + +                     K  KR           T+     LNPVW+E+F F
Sbjct: 220  CMLGILPASDATREPRAQKEQRFGFRKGSKRGGPLPAKCIQVTEVKSSTLNPVWKEHFLF 279

Query: 818  ECHN-SSDRIKVRVWDEDDDIK--------------SRVKQRFKR--------------- 847
            E  + S+D++ + +WD DDD+                 + + FK+               
Sbjct: 280  EIEDVSTDQLHLDIWDHDDDVSLVEACRKLNEVIGLKGMGRYFKQIVKSARANGTAGPTE 339

Query: 848  -ESDDFLGQTIIEVRTLS-GEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHV 905
              +DDFLG   I VR +    +D W+ L+ R+  S V G   L + +     +       
Sbjct: 340  DHTDDFLGCLNIPVREVPVAGVDRWFKLEPRSSASRVQGHCHLVLKLITTQRDTAMSQRG 399

Query: 906  QYTCL-HENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVESIYQ 964
            +   L H  L   +  ++++      +     +W+      A  I+     +  +  +  
Sbjct: 400  RSGFLSHLLLLSHLLRLEHSA-----EEPNSSSWRGELSTPAATILCLHGAQSNLSPLQL 454

Query: 965  AMTHFACLSSKYM-CPGVPAVMSTLLANINAYYAHTTA---STNVSASDRFAA-SNFGKE 1019
            A+ H+   S  +  C    + +  LL ++ A++    +       S +D  +A S FG  
Sbjct: 455  AVLHWQVSSRHHQTCTLDYSYLLGLLEDMQAHWEEAPSLPQEQEESLADSLSAFSEFG-- 512

Query: 1020 RFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQSPPR 1079
              ++LL QL           R+ FPA++   +  L+  +  L  +  F+   +       
Sbjct: 513  --LQLLRQL-----------RDYFPATNSTAVHRLELLLKCLGKLQLFQPSFEICPFESE 559

Query: 1080 ASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDFWSKL 1139
             +  +   +K      Y+ I N                  +  P EQ P  + L     L
Sbjct: 560  LNMDIAAALKRGNREWYDRILN------------------DKSPREQ-PGPQRLP---GL 597

Query: 1140 ITLIVSIIEEDKNSYTPCLNQFPQELNVG--KISAEVMWNLFAQDMKYAMEEHDKHRLCK 1197
            + L  ++ ++ +  Y+   + F   LNV    ++   +  L A++     EE       +
Sbjct: 598  VVLADAVYDDLQFCYSVYASLFHSILNVDVFTLTFRQLERLVAEEAWVLTEELSPKMTLE 657

Query: 1198 SADYMNLHFKVKWLYNEYVT--ELPAFKDRVPEYP----------AWFEPFVIQWLDENE 1245
             A           L+  Y+T  +L  F D +P             A F P V  W     
Sbjct: 658  VAS---------GLFELYLTLADLQRFWDSIPGRDSRSLALAGIHAPFLPAVKLWFQVLR 708

Query: 1246 EVSRDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHY 1305
            + ++  L GA++ D  +    +S H   S S       L+   E+  +L  PDP      
Sbjct: 709  DQAKWRLQGAVDMDTLEPVDASSRH---SSSAATAGLCLSHIQELWVRLAWPDPAQAQGL 765

Query: 1306 MRRFAKTISNVLLQYADIISKDFASYCSKEKEKVP---CILMNNTQQLRVQLEKMFEAMG 1362
              +  + +    L Y +++ K   +      E V    C+++NN + +R    +  + + 
Sbjct: 766  GTQLGQDVCEATLFYTELLRKKVDTQPGAAGEAVSEALCVVLNNVELVRKAAGQALKGLA 825

Query: 1363 GKELDAEASDILKELQVKLNNVLDELSRVFATSFQPHIEECVKQMGDILSQVKGTGNVPA 1422
              E       +L    +     LD+  +  A +   H+    K +GDI   V+     P 
Sbjct: 826  WPEGATGPEGVLPRPLLSCTQALDDDLQREAHTVTAHLTS--KMVGDIRKYVQHISLSPD 883

Query: 1423 SACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTM 1474
            S  +      D  + P+M  LD  L L      K  L RVL+ LW+L++  +
Sbjct: 884  SIQN------DEAVAPLMKYLDEKLALLNASLVKGNLSRVLEALWELLLQAI 929



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 44/157 (28%), Positives = 71/157 (45%), Gaps = 9/157 (5%)

Query: 1554 LDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQGLGVED 1613
            L+ +  +FHA G GL    L +    + L+  L L+  +T   I+ F   +  Q    ++
Sbjct: 951  LEALVSFFHAEGQGLPLESL-RDGSYKRLKEELRLHKCSTRECIEQFYLDKLKQRTLEQN 1009

Query: 1614 PVGEVSVHVELFTHPGTGEHKVTVKVVAANDL-KWQTSGIFRPFIEVNIIGPQLSDKKRK 1672
              G +SV      H    E ++ V+V+ A DL     +G+  PF+ V +  P L    R 
Sbjct: 1010 RFGRLSVRC----HYEAAEQRLAVEVLHAADLLPLDANGLSDPFVIVELGPPHLFPLVRS 1065

Query: 1673 FATKSKNNSWAPKYNESFQFTLSADAGPECYELQVCV 1709
              T+ K  +  P Y+E F F++ A+A   C     CV
Sbjct: 1066 QRTQVKTRTLHPVYDELFYFSVPAEA---CRRRAACV 1099



 Score = 35.0 bits (79), Expect = 0.66
 Identities = 32/132 (24%), Positives = 57/132 (43%), Gaps = 14/132 (10%)

Query: 715  LKDRMKIRERNKPEIFELIQEIFAVTKTAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQ 774
            LK+ +++ + +  E  E  Q      K    +Q +  + SV         ++++ V+ A 
Sbjct: 978  LKEELRLHKCSTRECIE--QFYLDKLKQRTLEQNRFGRLSVRCHYEAAEQRLAVEVLHAA 1035

Query: 775  GLQAKDKTGSSDPYVTVQVGKT-------KKRTKTIYGNLNPVWEENFHFE-----CHNS 822
             L   D  G SDP+V V++G          +RT+     L+PV++E F+F      C   
Sbjct: 1036 DLLPLDANGLSDPFVIVELGPPHLFPLVRSQRTQVKTRTLHPVYDELFYFSVPAEACRRR 1095

Query: 823  SDRIKVRVWDED 834
            +  +   V D D
Sbjct: 1096 AACVLFTVMDHD 1107


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score = 82.4 bits (202), Expect = 4e-15
 Identities = 64/256 (25%), Positives = 103/256 (40%), Gaps = 38/256 (14%)

Query: 642 HNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCL--------- 692
           H F       PT+C  C   +WGI +QG++C  C    H +C + +  +C          
Sbjct: 36  HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTD 95

Query: 693 -QRAAEKSSKHGAEDRT------QNIIMVLKDRMKIRERNKPEIFELIQEIFAVTKTAHT 745
             R   K   H     T        +  ++   MK            ++ + ++    HT
Sbjct: 96  DPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHT 155

Query: 746 QQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQV-----GKTKKRT 800
           ++   ++  +   T+    +I +TV  A+ L   D  G SDPYV +++       TK++T
Sbjct: 156 ERRGRLQLEIRAPTAD---EIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKT 212

Query: 801 KTIYGNLNPVWEENFHFECH--NSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTII 858
           +T+   LNPVW E F F     +   R+ V VWD D           +   +DF+G    
Sbjct: 213 RTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWD-----------RTSRNDFMGAMSF 261

Query: 859 EV-RTLSGEMDVWYNL 873
            V   L   +D WY L
Sbjct: 262 GVSELLKAPVDGWYKL 277


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 66/262 (25%), Positives = 106/262 (40%), Gaps = 51/262 (19%)

Query: 642 HNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSK 701
           H F       PT+C  C   +WG  +QG +C  C    H++C + +   C       + K
Sbjct: 37  HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC-----PGADK 91

Query: 702 HGAEDRTQNIIMVLKDRMKIRERNKPEIFE----LIQEIFAVTKTAHTQQMKAVKQSVLD 757
             A D  ++     K + KI   + P   +    L+  +        T  M   K+ V++
Sbjct: 92  GPASDDPRS-----KHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMN 146

Query: 758 -----GTSKWSAK-------------ISITVVCAQGLQAKDKTGSSDPYVTVQV-----G 794
                GT     +             + + V  A+ L   D  G SDPYV +++      
Sbjct: 147 VPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKS 206

Query: 795 KTKKRTKTIYGNLNPVWEENFHFECHNSSD--RIKVRVWDEDDDIKSRVKQRFKRESDDF 852
           ++K++TKTI  +LNP W E F F+   S    R+ V +WD   D+ SR         +DF
Sbjct: 207 ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDW--DLTSR---------NDF 255

Query: 853 LGQTIIEVRTL-SGEMDVWYNL 873
           +G     +  L    +D W+ L
Sbjct: 256 MGSLSFGISELQKASVDGWFKL 277



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 36/146 (24%), Positives = 69/146 (47%), Gaps = 8/146 (5%)

Query: 1641 AANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNNSWAPKYNESFQFTLSADAGP 1700
            A N +    +G+  P++++ +I    S+ K+K  TK+   S  P++NE+F+F L      
Sbjct: 180  AKNLVPMDPNGLSDPYVKLKLIPDPKSESKQK--TKTIKCSLNPEWNETFRFQLK--ESD 235

Query: 1701 ECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLRIL 1760
            +   L V + D+     +  +G     + EL Q+ S   W  L  +   +   + V    
Sbjct: 236  KDRRLSVEIWDWDLTSRNDFMGSLSFGISEL-QKASVDGWFKLLSQEEGEYFNVPVPPEG 294

Query: 1761 SQRSNDEVAKEF--VKLKSDTRSAEE 1784
            S+ +N+E+ ++F   K+   T+  EE
Sbjct: 295  SE-ANEELRQKFERAKISQGTKVPEE 319


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 66/262 (25%), Positives = 106/262 (40%), Gaps = 51/262 (19%)

Query: 642 HNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSK 701
           H F       PT+C  C   +WG  +QG +C  C    H++C + +   C       + K
Sbjct: 37  HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC-----PGADK 91

Query: 702 HGAEDRTQNIIMVLKDRMKIRERNKPEIFE----LIQEIFAVTKTAHTQQMKAVKQSVLD 757
             A D  ++     K + KI   + P   +    L+  +        T  M   K+ V++
Sbjct: 92  GPASDDPRS-----KHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMN 146

Query: 758 -----GTSKWSAK-------------ISITVVCAQGLQAKDKTGSSDPYVTVQV-----G 794
                GT     +             + + V  A+ L   D  G SDPYV +++      
Sbjct: 147 VPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKS 206

Query: 795 KTKKRTKTIYGNLNPVWEENFHFECHNSSD--RIKVRVWDEDDDIKSRVKQRFKRESDDF 852
           ++K++TKTI  +LNP W E F F+   S    R+ V +WD   D+ SR         +DF
Sbjct: 207 ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDW--DLTSR---------NDF 255

Query: 853 LGQTIIEVRTL-SGEMDVWYNL 873
           +G     +  L    +D W+ L
Sbjct: 256 MGSLSFGISELQKASVDGWFKL 277



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 36/146 (24%), Positives = 69/146 (47%), Gaps = 8/146 (5%)

Query: 1641 AANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNNSWAPKYNESFQFTLSADAGP 1700
            A N +    +G+  P++++ +I    S+ K+K  TK+   S  P++NE+F+F L      
Sbjct: 180  AKNLVPMDPNGLSDPYVKLKLIPDPKSESKQK--TKTIKCSLNPEWNETFRFQLK--ESD 235

Query: 1701 ECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLRIL 1760
            +   L V + D+     +  +G     + EL Q+ S   W  L  +   +   + V    
Sbjct: 236  KDRRLSVEIWDWDLTSRNDFMGSLSFGISEL-QKASVDGWFKLLSQEEGEYFNVPVPPEG 294

Query: 1761 SQRSNDEVAKEF--VKLKSDTRSAEE 1784
            S+ +N+E+ ++F   K+   T+  EE
Sbjct: 295  SE-ANEELRQKFERAKISQGTKVPEE 319


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score = 78.6 bits (192), Expect = 5e-14
 Identities = 68/262 (25%), Positives = 99/262 (37%), Gaps = 51/262 (19%)

Query: 642 HNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSK 701
           H F       PT+C  C   +WG  +QG +C  C    H++C + +   C          
Sbjct: 37  HKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC---------- 86

Query: 702 HGAEDRTQNIIMVLKDRMKIRERNKPEIFE----LIQEIFAVTKTAHTQQMKAVKQSVL- 756
            GA+          K + KI     P   +    L+  +        T  M   KQ V+ 
Sbjct: 87  PGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVIN 146

Query: 757 -------DGTSKWSA----------KISITVVCAQGLQAKDKTGSSDPYVTVQV-----G 794
                  D T K             K+ +TV  A+ L   D  G SDPYV +++      
Sbjct: 147 VPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKN 206

Query: 795 KTKKRTKTIYGNLNPVWEENFHFECHNSSD--RIKVRVWDEDDDIKSRVKQRFKRESDDF 852
           ++K++TKTI   LNP W E+F F+   S    R+ V +WD D           +   +DF
Sbjct: 207 ESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWD-----------RTTRNDF 255

Query: 853 LGQTIIEVRTL-SGEMDVWYNL 873
           +G     V  L       WY L
Sbjct: 256 MGSLSFGVSELMKMPASGWYKL 277



 Score = 31.6 bits (70), Expect = 7.2
 Identities = 16/54 (29%), Positives = 32/54 (59%), Gaps = 2/54 (3%)

Query: 1641 AANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNNSWAPKYNESFQFTL 1694
            A N +    +G+  P++++ +I    ++ K+K  TK+  ++  P++NESF F L
Sbjct: 180  AKNLIPMDPNGLSDPYVKLKLIPDPKNESKQK--TKTIRSTLNPQWNESFTFKL 231


>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
           sapiens]
          Length = 762

 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 27/55 (49%), Positives = 39/55 (70%)

Query: 641 PHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRA 695
           PHNF+  T   PT+C  C G LWG+ +QG RC +CG+ CH++C+DL+  +C +RA
Sbjct: 506 PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRA 560


>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
           sapiens]
          Length = 797

 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 27/55 (49%), Positives = 39/55 (70%)

Query: 641 PHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRA 695
           PHNF+  T   PT+C  C G LWG+ +QG RC +CG+ CH++C+DL+  +C +RA
Sbjct: 541 PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRA 595


>gi|213385270 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 31/65 (47%), Positives = 40/65 (61%), Gaps = 2/65 (3%)

Query: 642 HNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADC--LQRAAEKS 699
           HNF+  T   PT+C  C G LWGI +QG +C +CG  CH++C+DLL   C    RA   S
Sbjct: 495 HNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLS 554

Query: 700 SKHGA 704
           S HG+
Sbjct: 555 SGHGS 559


>gi|24762239 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 31/65 (47%), Positives = 40/65 (61%), Gaps = 2/65 (3%)

Query: 642 HNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADC--LQRAAEKS 699
           HNF+  T   PT+C  C G LWGI +QG +C +CG  CH++C+DLL   C    RA   S
Sbjct: 495 HNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLS 554

Query: 700 SKHGA 704
           S HG+
Sbjct: 555 SGHGS 559


>gi|7662334 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 2 [Homo sapiens]
          Length = 689

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 31/65 (47%), Positives = 40/65 (61%), Gaps = 2/65 (3%)

Query: 642 HNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADC--LQRAAEKS 699
           HNF+  T   PT+C  C G LWGI +QG +C +CG  CH++C+DLL   C    RA   S
Sbjct: 494 HNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLS 553

Query: 700 SKHGA 704
           S HG+
Sbjct: 554 SGHGS 558


>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
           sapiens]
          Length = 778

 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 41/127 (32%), Positives = 60/127 (47%), Gaps = 11/127 (8%)

Query: 766 ISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDR 825
           + + V+ A+GL A D TG SDP+  V++   +  T T+Y NLNP W + F F   +    
Sbjct: 407 LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSV 466

Query: 826 IKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGA 885
           ++V V+DED D            S DFLG+  I + ++       Y L  +       G 
Sbjct: 467 LEVTVYDEDRD-----------RSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGV 515

Query: 886 IRLHISV 892
           I L I V
Sbjct: 516 IYLEIDV 522



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 34/106 (32%), Positives = 53/106 (50%), Gaps = 12/106 (11%)

Query: 762 WSAKISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHN 821
           W   +SIT++  + L+A D  G SDPYV  ++G  K ++K +   LNP W E F F  + 
Sbjct: 247 WRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYE 306

Query: 822 S-SDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGE 866
                I +  WD+D             + DDF+G+  +++  LS E
Sbjct: 307 ERGGVIDITAWDKD-----------AGKRDDFIGRCQVDLSALSRE 341



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 33/100 (33%), Positives = 55/100 (55%), Gaps = 12/100 (12%)

Query: 765 KISITVVCAQGLQAKDKTGSSDPYVTVQVG-KTKKRTKTIYGNLNPVWEENFHFECHNSS 823
           ++ IT+   Q L A+D+ G+SDPYV  ++G K   R+K I+ NLNPVWEE       +  
Sbjct: 41  QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLR 100

Query: 824 DRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTL 863
           + + ++V+D D  ++           DDF+G   +++  L
Sbjct: 101 EPLYIKVFDYDFGLQ-----------DDFMGSAFLDLTQL 129


>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
           sapiens]
          Length = 999

 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 41/127 (32%), Positives = 60/127 (47%), Gaps = 11/127 (8%)

Query: 766 ISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDR 825
           + + V+ A+GL A D TG SDP+  V++   +  T T+Y NLNP W + F F   +    
Sbjct: 628 LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSV 687

Query: 826 IKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGA 885
           ++V V+DED D            S DFLG+  I + ++       Y L  +       G 
Sbjct: 688 LEVTVYDEDRD-----------RSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGV 736

Query: 886 IRLHISV 892
           I L I V
Sbjct: 737 IYLEIDV 743



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 34/106 (32%), Positives = 53/106 (50%), Gaps = 12/106 (11%)

Query: 762 WSAKISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHN 821
           W   +SIT++  + L+A D  G SDPYV  ++G  K ++K +   LNP W E F F  + 
Sbjct: 468 WRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYE 527

Query: 822 S-SDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGE 866
                I +  WD+D             + DDF+G+  +++  LS E
Sbjct: 528 ERGGVIDITAWDKD-----------AGKRDDFIGRCQVDLSALSRE 562



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 48/186 (25%), Positives = 76/186 (40%), Gaps = 30/186 (16%)

Query: 679 CHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFELIQEIFA 738
           CH+K   L    CL++  E         R+              E   PE  E       
Sbjct: 194 CHQKSSSLPGTACLEQLLEPPPPPAEPARSP------------AESRAPETGEEHGSSQK 241

Query: 739 VTKTAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQVG-KTK 797
           +  TA T   +               ++ IT+   Q L A+D+ G+SDPYV  ++G K  
Sbjct: 242 IINTAGTSNAEVPL------ADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEV 295

Query: 798 KRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTI 857
            R+K I+ NLNPVWEE       +  + + ++V+D D  ++           DDF+G   
Sbjct: 296 FRSKIIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQ-----------DDFMGSAF 344

Query: 858 IEVRTL 863
           +++  L
Sbjct: 345 LDLTQL 350


>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
          Length = 673

 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%)

Query: 614 TLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCT 673
           + + EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG RC 
Sbjct: 515 SFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 572

Query: 674 ECGVKCHEKCQDLLNADCLQRAAEK 698
           ECG+ CH+ C+D +  +C +R   K
Sbjct: 573 ECGLCCHKHCRDQVKVECKKRPGAK 597


>gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo
           sapiens]
          Length = 576

 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%)

Query: 614 TLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCT 673
           + + EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG RC 
Sbjct: 418 SFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 475

Query: 674 ECGVKCHEKCQDLLNADCLQRAAEK 698
           ECG+ CH+ C+D +  +C +R   K
Sbjct: 476 ECGLCCHKHCRDQVKVECKKRPGAK 500


>gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo
           sapiens]
          Length = 484

 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%)

Query: 614 TLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCT 673
           + + EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG RC 
Sbjct: 326 SFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 383

Query: 674 ECGVKCHEKCQDLLNADCLQRAAEK 698
           ECG+ CH+ C+D +  +C +R   K
Sbjct: 384 ECGLCCHKHCRDQVKVECKKRPGAK 408


>gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo
           sapiens]
          Length = 639

 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%)

Query: 614 TLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCT 673
           + + EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG RC 
Sbjct: 481 SFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 538

Query: 674 ECGVKCHEKCQDLLNADCLQRAAEK 698
           ECG+ CH+ C+D +  +C +R   K
Sbjct: 539 ECGLCCHKHCRDQVKVECKKRPGAK 563


>gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo
           sapiens]
          Length = 604

 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%)

Query: 614 TLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCT 673
           + + EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG RC 
Sbjct: 446 SFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 503

Query: 674 ECGVKCHEKCQDLLNADCLQRAAEK 698
           ECG+ CH+ C+D +  +C +R   K
Sbjct: 504 ECGLCCHKHCRDQVKVECKKRPGAK 528


>gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo
           sapiens]
          Length = 581

 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%)

Query: 614 TLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCT 673
           + + EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG RC 
Sbjct: 423 SFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 480

Query: 674 ECGVKCHEKCQDLLNADCLQRAAEK 698
           ECG+ CH+ C+D +  +C +R   K
Sbjct: 481 ECGLCCHKHCRDQVKVECKKRPGAK 505


>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
           sapiens]
          Length = 659

 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%)

Query: 614 TLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCT 673
           + + EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG RC 
Sbjct: 501 SFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCR 558

Query: 674 ECGVKCHEKCQDLLNADCLQRAAEK 698
           ECG+ CH+ C+D +  +C +R   K
Sbjct: 559 ECGLCCHKHCRDQVKVECKKRPGAK 583


>gi|148839284 Ca2+-dependent activator protein for secretion 2 isoform
            b [Homo sapiens]
          Length = 1255

 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 109/528 (20%), Positives = 216/528 (40%), Gaps = 52/528 (9%)

Query: 949  IVDEFAMRYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSAS 1008
            ++DE+  RYGV   ++ + + A L        V  +  TLL    A+ A           
Sbjct: 673  VLDEYCARYGVRGCHRHLCYLAELMEHSENGAV--IDPTLLHYSFAFCASHVHGNRPDGI 730

Query: 1009 DRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFR 1068
               +     KERF ++ ++L + L   +S +R  FP   PE    LK+T+ LL      R
Sbjct: 731  GTVSVEE--KERFEEIKERLSSLLENQISHFRYCFPFGRPEGA--LKATLSLLE-----R 781

Query: 1069 MKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGP 1128
            + ++++ +P  A + VK  V+ CL             L +    T+ AK  E +   Q  
Sbjct: 782  VLMKDIATPIPAEE-VKKVVRKCLEKA---------ALINYTRLTEYAKIEETM--NQAS 829

Query: 1129 SIKNLDFWSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAME 1188
              + L+    L  L + ++++++  +      +P  L      AE  W LF  DM  A+E
Sbjct: 830  PARKLEEILHLAELCIEVLQQNEEHHAEAFAWWPDLL---AEHAEKFWALFTVDMDTALE 886

Query: 1189 EHDKHRLCKSADYMNLHFKVKWLYNEYVTELPAFKDRVPEYPAWFEPFVIQWLDENEEVS 1248
               +        +  L+    +L N+ +     F   + E    F P V++++D  E   
Sbjct: 887  AQPQDSWDSFPLFQLLN---NFLRNDTLLCNGKFHKHLQEI---FVPLVVRYVDLMESSI 940

Query: 1249 RDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRR 1308
               +H   E++    +Q  +     S +  D+F +L+     +  L  P+ +   H  +R
Sbjct: 941  AQSIHRGFEQET---WQPVNNG---SATSEDLFWKLDALQMFVFDLHWPEQEFAHHLEQR 994

Query: 1309 FAKTISNVLLQYADIISKDFASYCSKEKE----KVP---CILMNNTQQLRVQLEKMFEAM 1361
                 S++L          F     K  +    ++P   C + N     + Q  K+    
Sbjct: 995  LKLMASDMLEACVKRTRTAFELKLQKASKTTDLRIPASVCTMFNVLVDAKKQSTKLCALD 1054

Query: 1362 GGKELDAEASDILKELQVKLNNVLDELSRVFATSFQPHIEECVKQMGDILSQVKGT--GN 1419
            GG+E  ++      ++   ++N + E+  +  + F   +E  + ++       +GT   +
Sbjct: 1055 GGQEFGSQWQQYHSKIDDLIDNSVKEIISLLVSKFVSVLEGVLSKLS---RYDEGTFFSS 1111

Query: 1420 VPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELW 1467
            + +    + A+  D V +P MDL D+ + +F +  +  + ++V +E++
Sbjct: 1112 ILSFTVKAAAKYVD-VPKPGMDLADTYI-MFVRQNQDILREKVNEEMY 1157


>gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Homo
           sapiens]
          Length = 823

 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 38/127 (29%), Positives = 63/127 (49%), Gaps = 11/127 (8%)

Query: 766 ISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDR 825
           + + V+ A  L A D +G SDP+  +++G  + +T T+Y NLNP W + F F   +  D 
Sbjct: 511 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 570

Query: 826 IKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGA 885
           ++V V+DED D           +  DFLG+  I + ++       Y L  +  + A  G 
Sbjct: 571 LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 619

Query: 886 IRLHISV 892
           I L + +
Sbjct: 620 IYLEMDL 626



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 27/76 (35%), Positives = 47/76 (61%), Gaps = 1/76 (1%)

Query: 760 SKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQV-GKTKKRTKTIYGNLNPVWEENFHFE 818
           S ++  ++I +   + L  +D+ G+SDPYV  ++ GKT  ++K IY NLNPVW+E     
Sbjct: 190 SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLP 249

Query: 819 CHNSSDRIKVRVWDED 834
             +   +++V+V+D D
Sbjct: 250 IQSLDQKLRVKVYDRD 265



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 12/79 (15%)

Query: 762 WSAKISITVVCAQGLQAKDKTGSS--DPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFEC 819
           W+  ISIT+     L+ K+ +G S  + +V +++G  + ++KT+  + NP W+E F F  
Sbjct: 354 WNGIISITL-----LEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDF-- 406

Query: 820 HNSSDR---IKVRVWDEDD 835
           H  SDR   + + VW +D+
Sbjct: 407 HYFSDRMGILDIEVWGKDN 425


>gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Homo
           sapiens]
          Length = 878

 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 38/127 (29%), Positives = 63/127 (49%), Gaps = 11/127 (8%)

Query: 766 ISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDR 825
           + + V+ A  L A D +G SDP+  +++G  + +T T+Y NLNP W + F F   +  D 
Sbjct: 511 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 570

Query: 826 IKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGA 885
           ++V V+DED D           +  DFLG+  I + ++       Y L  +  + A  G 
Sbjct: 571 LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 619

Query: 886 IRLHISV 892
           I L + +
Sbjct: 620 IYLEMDL 626



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 27/76 (35%), Positives = 47/76 (61%), Gaps = 1/76 (1%)

Query: 760 SKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQV-GKTKKRTKTIYGNLNPVWEENFHFE 818
           S ++  ++I +   + L  +D+ G+SDPYV  ++ GKT  ++K IY NLNPVW+E     
Sbjct: 190 SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLP 249

Query: 819 CHNSSDRIKVRVWDED 834
             +   +++V+V+D D
Sbjct: 250 IQSLDQKLRVKVYDRD 265



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 12/79 (15%)

Query: 762 WSAKISITVVCAQGLQAKDKTGSS--DPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFEC 819
           W+  ISIT+     L+ K+ +G S  + +V +++G  + ++KT+  + NP W+E F F  
Sbjct: 354 WNGIISITL-----LEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDF-- 406

Query: 820 HNSSDR---IKVRVWDEDD 835
           H  SDR   + + VW +D+
Sbjct: 407 HYFSDRMGILDIEVWGKDN 425


>gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Homo
           sapiens]
          Length = 306

 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 38/127 (29%), Positives = 63/127 (49%), Gaps = 11/127 (8%)

Query: 766 ISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDR 825
           + + V+ A  L A D +G SDP+  +++G  + +T T+Y NLNP W + F F   +  D 
Sbjct: 99  LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 158

Query: 826 IKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGA 885
           ++V V+DED D           +  DFLG+  I + ++       Y L  +  + A  G 
Sbjct: 159 LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 207

Query: 886 IRLHISV 892
           I L + +
Sbjct: 208 IYLEMDL 214


>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 25/63 (39%), Positives = 39/63 (61%)

Query: 642 HNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSK 701
           HNF+   +  P  C  C+ L+ GI +QG++C  CGV CH++C+D L+ +C +RA   S +
Sbjct: 499 HNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLE 558

Query: 702 HGA 704
             A
Sbjct: 559 GSA 561


>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 25/63 (39%), Positives = 39/63 (61%)

Query: 642 HNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSK 701
           HNF+   +  P  C  C+ L+ GI +QG++C  CGV CH++C+D L+ +C +RA   S +
Sbjct: 499 HNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLE 558

Query: 702 HGA 704
             A
Sbjct: 559 GSA 561


>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 25/63 (39%), Positives = 39/63 (61%)

Query: 642 HNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSK 701
           HNF+   +  P  C  C+ L+ GI +QG++C  CGV CH++C+D L+ +C +RA   S +
Sbjct: 499 HNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLE 558

Query: 702 HGA 704
             A
Sbjct: 559 GSA 561


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,176,971
Number of Sequences: 37866
Number of extensions: 3712010
Number of successful extensions: 35293
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 367
Number of HSP's successfully gapped in prelim test: 715
Number of HSP's that attempted gapping in prelim test: 21471
Number of HSP's gapped (non-prelim): 7751
length of query: 1791
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1674
effective length of database: 13,817,196
effective search space: 23129986104
effective search space used: 23129986104
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.