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Search of human proteins with 28605145
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
[Homo sapiens]
(919 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ... 1863 0.0
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ... 1483 0.0
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ... 1399 0.0
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ... 1358 0.0
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p... 1337 0.0
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens] 709 0.0
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens] 680 0.0
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H... 606 e-173
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H... 604 e-172
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr... 595 e-170
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H... 594 e-169
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre... 594 e-169
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p... 590 e-168
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p... 587 e-167
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p... 585 e-167
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p... 584 e-166
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H... 360 3e-99
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens] 345 9e-95
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 248 2e-65
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 244 3e-64
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 244 3e-64
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ... 185 2e-46
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 183 7e-46
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 183 7e-46
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 183 7e-46
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ... 181 2e-45
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [... 172 2e-42
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate... 154 4e-37
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat... 153 6e-37
gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3 p... 151 3e-36
>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
[Homo sapiens]
Length = 919
Score = 1863 bits (4827), Expect = 0.0
Identities = 919/919 (100%), Positives = 919/919 (100%)
Query: 1 MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAF 60
MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAF
Sbjct: 1 MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAF 60
Query: 61 RFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA 120
RFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA
Sbjct: 61 RFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA 120
Query: 121 VQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYD 180
VQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYD
Sbjct: 121 VQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYD 180
Query: 181 DSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQ 240
DSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQ
Sbjct: 181 DSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQ 240
Query: 241 ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWS 300
ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWS
Sbjct: 241 ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWS 300
Query: 301 MERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGG 360
MERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGG
Sbjct: 301 MERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGG 360
Query: 361 RFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA 420
RFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA
Sbjct: 361 RFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA 420
Query: 421 KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS 480
KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS
Sbjct: 421 KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS 480
Query: 481 YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV 540
YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV
Sbjct: 481 YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV 540
Query: 541 SILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG 600
SILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG
Sbjct: 541 SILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG 600
Query: 601 SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF 660
SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF
Sbjct: 601 SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF 660
Query: 661 LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVK 720
LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVK
Sbjct: 661 LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVK 720
Query: 721 NNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKIT 780
NNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKIT
Sbjct: 721 NNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKIT 780
Query: 781 IAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV 840
IAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV
Sbjct: 781 IAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV 840
Query: 841 GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDR 900
GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDR
Sbjct: 841 GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDR 900
Query: 901 RLPGKDSMACSTSLAPVFP 919
RLPGKDSMACSTSLAPVFP
Sbjct: 901 RLPGKDSMACSTSLAPVFP 919
>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
Length = 908
Score = 1483 bits (3840), Expect = 0.0
Identities = 719/894 (80%), Positives = 808/894 (90%), Gaps = 7/894 (0%)
Query: 19 LLVCAFWIPDSRGMPHVIRIGGIFEYAD-GPNAQVMNAEEHAFRFSANIINRNRTLLPNT 77
LL+C WI S+G HV+R GGIFEY + GP M AEE AFRF+ N INRNRTLLPNT
Sbjct: 19 LLLCLLWIGYSQGTTHVLRFGGIFEYVESGP----MGAEELAFRFAVNTINRNRTLLPNT 74
Query: 78 TLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRW 137
TLTYD Q+I+ +DSFEA+KKACDQL+LGV AIFGPS S NAVQSICNAL VPHIQ RW
Sbjct: 75 TLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRW 134
Query: 138 KHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSR 197
KH DNKD+FYV+LYPD++SLS AILDLVQ+ KW++ TVVYDDSTGLIRLQELI APSR
Sbjct: 135 KHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSR 194
Query: 198 YNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHF 257
YN+RLKIRQLP D+ D++PLLKEMKRG+EF +IFDCSH MAA ILKQA+AMGMMTEYYH+
Sbjct: 195 YNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHY 254
Query: 258 IFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDG 317
IFTTLDL+ALD+EPYRYSGVN+TGFRILN +N VS+I+EKWSMERLQA P+ +SGLLDG
Sbjct: 255 IFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDG 314
Query: 318 VMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGR 377
M TDAAL+YDAVH+VSV Q+ PQMTV+SLQC+RHK WRFG RFM+ IKEA WEGLTGR
Sbjct: 315 FMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGR 374
Query: 378 IVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLI 437
I FNKT+GLRTDFDLD+ISLKE+GLEK+G W PA GLN+TE KG+ N+TDSL+NRSLI
Sbjct: 375 ITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLI 434
Query: 438 VTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDD- 496
VTT+LEEP+V+F+KSD+ LYGNDRFEGYCIDLL+EL+ ILGF+YEIRLVEDGKYGAQDD
Sbjct: 435 VTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDA 494
Query: 497 KGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFS 556
GQWNGMV+ELIDHKADLAVAPL IT+VREK IDFSKPFMTLG+SILYRKPNGTNP VFS
Sbjct: 495 NGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFS 554
Query: 557 FLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWF 616
FLNPLSPDIWMY+LLAYLGVSCVLFVIARFSPYEWY+ HPCNP S+VVENNFTLLNSFWF
Sbjct: 555 FLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWF 614
Query: 617 GMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL 676
G+G+LMQQGSELMPKALSTRI+GGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL
Sbjct: 615 GVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL 674
Query: 677 AKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSS-KPSALVKNNEEGIQRALTADYA 735
AKQTKIEYGAV+DGATMTFFKKSKIST++KMWAFMSS + S LVK+NEEGIQR LT+DYA
Sbjct: 675 AKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYA 734
Query: 736 LLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIM 795
LMESTTIE+VTQRNCNLTQIGGLIDSKGYG+GTPMGSPYRDKITIAILQLQEE KLH+M
Sbjct: 735 FLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMM 794
Query: 796 KEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQ 855
KEKWWRG+GCPEEE+KEASALG+Q IGGIFIVLAAGLVLSV VAVGEF+YK +K A+ E+
Sbjct: 795 KEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEK 854
Query: 856 RSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMA 909
RSFCS + +E+R SL CQRR+KHKPQ P++VKT+ VINMHTFNDRRLPGK++MA
Sbjct: 855 RSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA 908
>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
precursor [Homo sapiens]
Length = 869
Score = 1399 bits (3622), Expect = 0.0
Identities = 681/842 (80%), Positives = 761/842 (90%), Gaps = 7/842 (0%)
Query: 19 LLVCAFWIPDSRGMPHVIRIGGIFEYAD-GPNAQVMNAEEHAFRFSANIINRNRTLLPNT 77
LL+C WI S+G HV+R GGIFEY + GP M AEE AFRF+ N INRNRTLLPNT
Sbjct: 19 LLLCLLWIGYSQGTTHVLRFGGIFEYVESGP----MGAEELAFRFAVNTINRNRTLLPNT 74
Query: 78 TLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRW 137
TLTYD Q+I+ +DSFEA+KKACDQL+LGV AIFGPS S NAVQSICNAL VPHIQ RW
Sbjct: 75 TLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRW 134
Query: 138 KHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSR 197
KH DNKD+FYV+LYPD++SLS AILDLVQ+ KW++ TVVYDDSTGLIRLQELI APSR
Sbjct: 135 KHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSR 194
Query: 198 YNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHF 257
YN+RLKIRQLP D+ D++PLLKEMKRG+EF +IFDCSH MAA ILKQA+AMGMMTEYYH+
Sbjct: 195 YNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHY 254
Query: 258 IFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDG 317
IFTTLDL+ALD+EPYRYSGVN+TGFRILN +N VS+I+EKWSMERLQA P+ +SGLLDG
Sbjct: 255 IFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDG 314
Query: 318 VMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGR 377
M TDAAL+YDAVH+VSV Q+ PQMTV+SLQC+RHK WRFG RFM+ IKEA WEGLTGR
Sbjct: 315 FMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGR 374
Query: 378 IVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLI 437
I FNKT+GLRTDFDLD+ISLKE+GLEK+G W PA GLN+TE KG+ N+TDSL+NRSLI
Sbjct: 375 ITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLI 434
Query: 438 VTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDD- 496
VTT+LEEP+V+F+KSD+ LYGNDRFEGYCIDLL+EL+ ILGF+YEIRLVEDGKYGAQDD
Sbjct: 435 VTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDA 494
Query: 497 KGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFS 556
GQWNGMV+ELIDHKADLAVAPL IT+VREK IDFSKPFMTLG+SILYRKPNGTNP VFS
Sbjct: 495 NGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFS 554
Query: 557 FLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWF 616
FLNPLSPDIWMY+LLAYLGVSCVLFVIARFSPYEWY+ HPCNP S+VVENNFTLLNSFWF
Sbjct: 555 FLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWF 614
Query: 617 GMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL 676
G+G+LMQQGSELMPKALSTRI+GGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL
Sbjct: 615 GVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL 674
Query: 677 AKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSS-KPSALVKNNEEGIQRALTADYA 735
AKQTKIEYGAV+DGATMTFFKKSKIST++KMWAFMSS + S LVK+NEEGIQR LT+DYA
Sbjct: 675 AKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYA 734
Query: 736 LLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIM 795
LMESTTIE+VTQRNCNLTQIGGLIDSKGYG+GTPMGSPYRDKITIAILQLQEE KLH+M
Sbjct: 735 FLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMM 794
Query: 796 KEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQ 855
KEKWWRG+GCPEEE+KEASALG+Q IGGIFIVLAAGLVLSV VAVGEF+YK +K A+ E+
Sbjct: 795 KEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEK 854
Query: 856 RS 857
S
Sbjct: 855 ES 856
>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
Length = 905
Score = 1358 bits (3516), Expect = 0.0
Identities = 657/895 (73%), Positives = 773/895 (86%), Gaps = 9/895 (1%)
Query: 16 WAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLP 75
WA L + +P + P V+RIGGIFE + + +N EE AF+F+ INRNRTL+P
Sbjct: 19 WALLYFLCYILPQTA--PQVLRIGGIFETVEN---EPVNVEELAFKFAVTSINRNRTLMP 73
Query: 76 NTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQL 135
NTTLTYDIQRI+ DSFEA+++ACDQLALGV A+FGPS S +AVQSICNALEVPHIQ
Sbjct: 74 NTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQT 133
Query: 136 RWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAP 195
RWKH +DNKD FY+NLYPDYA++S AILDLV Y W++ TVVY+DSTGLIRLQELI AP
Sbjct: 134 RWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAP 193
Query: 196 SRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYY 255
SRYNI++KIRQLP + D++PLLKEMK+G+EF +IFDCSH AA+ILKQ + MGMMTEYY
Sbjct: 194 SRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYY 253
Query: 256 HFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLL 315
H+ FTTLDL+ALDLE YRYSGVN+TGFR+LN+DNPHVS+I+EKWSMERLQA PR E+GLL
Sbjct: 254 HYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLL 313
Query: 316 DGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLT 375
DG+M T+AAL+YDAV++V++ RA Q+TV+SLQCHRHK WR G RFMN IKEA+W+GLT
Sbjct: 314 DGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLT 373
Query: 376 GRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRS 435
G I FNKT+GLR DFDLDIISLKE+G EK+G+W+ GLN+T+ K + N+TDSL NR+
Sbjct: 374 GHITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRT 433
Query: 436 LIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQD 495
LIVTT+LEEP+VM+RKSD+ LYGNDRFEGYC+DLLKEL++ILGF Y+++LV DGKYGAQ+
Sbjct: 434 LIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQN 493
Query: 496 DKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVF 555
DKG+WNGMVKELIDH+ADLAVAPLTIT+VREK IDFSKPFMTLG+SILYRKPNGTNP VF
Sbjct: 494 DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 553
Query: 556 SFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFW 615
SFLNPLSPDIWMYVLLA LGVSCVLFVIARF+PYEWY+ HPCNP S+VVENNFTLLNSFW
Sbjct: 554 SFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFW 613
Query: 616 FGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD 675
FG+G+LMQQGSELMPKALSTRI+GGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD
Sbjct: 614 FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD 673
Query: 676 LAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSK-PSALVKNNEEGIQRALTADY 734
LAKQTKIEYGAV+DG+TMTFFKKSKIST+EKMWAFMSS+ +ALV+N++EGIQR LT DY
Sbjct: 674 LAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDY 733
Query: 735 ALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHI 794
ALLMEST+IEYVTQRNCNLTQIGGLIDSKGYG+GTP+GSPYRDKITIAILQLQEE KLH+
Sbjct: 734 ALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHM 793
Query: 795 MKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAERE 854
MKEKWWRG+GCPEE+NKEASALG++ IGGIFIVLAAGLVLSV VA+GEF+YK RK + E
Sbjct: 794 MKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIE 853
Query: 855 QRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMA 909
Q + + +E+ SL Q+++K K + +++ H RR K+++A
Sbjct: 854 QCLSFNAIMEELGISLKNQKKIKKKSRTKGKSSFTSILTCH---QRRTQRKETVA 905
>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
Length = 918
Score = 1337 bits (3461), Expect = 0.0
Identities = 648/860 (75%), Positives = 751/860 (87%), Gaps = 22/860 (2%)
Query: 16 WAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLP 75
WA L + +P + P V+RIGGIFE + + +N EE AF+F+ INRNRTL+P
Sbjct: 19 WALLYFLCYILPQTA--PQVLRIGGIFETVEN---EPVNVEELAFKFAVTSINRNRTLMP 73
Query: 76 NTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQL 135
NTTLTYDIQRI+ DSFEA+++ACDQLALGV A+FGPS S +AVQSICNALEVPHIQ
Sbjct: 74 NTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQT 133
Query: 136 RWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAP 195
RWKH +DNKD FY+NLYPDYA++S AILDLV Y W++ TVVY+DSTGLIRLQELI AP
Sbjct: 134 RWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAP 193
Query: 196 SRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYY 255
SRYNI++KIRQLP + D++PLLKEMK+G+EF +IFDCSH AA+ILKQ + MGMMTEYY
Sbjct: 194 SRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYY 253
Query: 256 HFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLL 315
H+ FTTLDL+ALDLE YRYSGVN+TGFR+LN+DNPHVS+I+EKWSMERLQA PR E+GLL
Sbjct: 254 HYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLL 313
Query: 316 DGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLT 375
DG+M T+AAL+YDAV++V++ RA Q+TV+SLQCHRHK WR G RFMN IKEA+W+GLT
Sbjct: 314 DGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLT 373
Query: 376 GRIVFNKTSGLRTDFDLDIISLKEDGLEK---------------VGVWSPADGLNITEVA 420
G I FNKT+GLR DFDLDIISLKE+G EK +G+W+ GLN+T+
Sbjct: 374 GHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSN 433
Query: 421 KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS 480
K + N+TDSL NR+LIVTT+LEEP+VM+RKSD+ LYGNDRFEGYC+DLLKEL++ILGF
Sbjct: 434 KDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFI 493
Query: 481 YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV 540
Y+++LV DGKYGAQ+DKG+WNGMVKELIDH+ADLAVAPLTIT+VREK IDFSKPFMTLG+
Sbjct: 494 YDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGI 553
Query: 541 SILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG 600
SILYRKPNGTNP VFSFLNPLSPDIWMYVLLA LGVSCVLFVIARF+PYEWY+ HPCNP
Sbjct: 554 SILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPD 613
Query: 601 SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF 660
S+VVENNFTLLNSFWFG+G+LMQQGSELMPKALSTRI+GGIWWFFTLIIISSYTANLAAF
Sbjct: 614 SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF 673
Query: 661 LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSK-PSALV 719
LTVERMESPIDSADDLAKQTKIEYGAV+DG+TMTFFKKSKIST+EKMWAFMSS+ +ALV
Sbjct: 674 LTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALV 733
Query: 720 KNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKI 779
+N++EGIQR LT DYALLMEST+IEYVTQRNCNLTQIGGLIDSKGYG+GTP+GSPYRDKI
Sbjct: 734 RNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKI 793
Query: 780 TIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVA 839
TIAILQLQEE KLH+MKEKWWRG+GCPEE+NKEASALG++ IGGIFIVLAAGLVLSV VA
Sbjct: 794 TIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVA 853
Query: 840 VGEFVYKLRKTAEREQRSFC 859
+GEF+YK RK + EQ +FC
Sbjct: 854 IGEFIYKSRKNNDIEQ-AFC 872
>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
Length = 980
Score = 709 bits (1831), Expect = 0.0
Identities = 375/828 (45%), Positives = 531/828 (64%), Gaps = 15/828 (1%)
Query: 82 DIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCT-NAVQSICNALEVPHIQLRWKHH 140
DI + +E T C L GVV++ GPS + + V IC E+PHI++ +
Sbjct: 66 DIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEET 125
Query: 141 P-LDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYN 199
P L V+LYP +S A+ +++ + SA+++ + L+RL+EL+
Sbjct: 126 PRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISK 185
Query: 200 IRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIF 259
L +R L DS D PLLKE++ + II D + +++ IL++A +GM + +Y +I
Sbjct: 186 ETLSVRMLD-DSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYIL 244
Query: 260 TTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVM 319
TT+D L L+ N+ GF + N +P V +M + E+ G
Sbjct: 245 TTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRE---NCEASTYLGPA 301
Query: 320 MTDAALLYDAVHIVSVCYQ---RAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTG 376
++ AAL++DAVH+V + R+ ++ V L C W G MN+++ +++GLTG
Sbjct: 302 LS-AALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTG 360
Query: 377 RIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSL 436
R+ FN + G RT++ L I+ G ++GVW L + A N++ +L N++L
Sbjct: 361 RVEFN-SKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMN--ATTLDINLSQTLANKTL 417
Query: 437 IVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDD 496
+VTT+LE P+VM R + + L GN+RFEG+C+D+L+ELA +L F Y +RLVEDG YGA +
Sbjct: 418 VVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEP 477
Query: 497 KGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFS 556
G W GMV ELI+ KADLAVA TIT REK IDFSKPFMTLG+SILYR G P FS
Sbjct: 478 NGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS 537
Query: 557 FLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPC-NPGSEVVENNFTLLNSFW 615
FL+P SP +W+++LLAYL VSCVLF+ AR SPYEWY+ HPC ++EN +TL NS W
Sbjct: 538 FLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLW 597
Query: 616 FGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD 675
F +G MQQGSE+MP+ALSTR + G+WW FTLIIISSYTANLAAFLTV+RME P++SADD
Sbjct: 598 FPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADD 657
Query: 676 LAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSK-PSALVKNNEEGIQRALTADY 734
LA QT IEYG + G+TMTFF+ S+ T+++MW +M SK PS VK+ EEGI R L + Y
Sbjct: 658 LADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRY 717
Query: 735 ALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHI 794
A L+EST EY + NCNLTQIGGL+D+KGYGIG P+GSP+RD+IT+AILQLQE ++L I
Sbjct: 718 AFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEI 777
Query: 795 MKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAERE 854
+K KWW G CP+EE+ A LG++ IGGIFIVL GL+++V VAV EF++ R++AE E
Sbjct: 778 LKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESE 837
Query: 855 QRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRL 902
+ S C + E+R +++C++ + + + + A++++ + RL
Sbjct: 838 EVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRL 885
>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
Length = 956
Score = 680 bits (1754), Expect = 0.0
Identities = 377/887 (42%), Positives = 537/887 (60%), Gaps = 36/887 (4%)
Query: 17 AGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPN 76
A L++ W+ PH +RI I D P + E + + N INR L
Sbjct: 6 APLVLLPAWLVMVACSPHSLRIAAIL---DDP-MECSRGERLSITLAKNRINRAPERLGK 61
Query: 77 TTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQS-ICNALEVPHIQL 135
+ DI + +E + C L GVVA+ GPS ++++ S IC EVPH ++
Sbjct: 62 AKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKV 121
Query: 136 RWKHHPLDNKDTFY-VNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMA 194
+ F +NL+P +S A+ ++ + +A ++ + L+ L++L+
Sbjct: 122 APEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQ 181
Query: 195 PSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEY 254
L +R L D+ D PLLKE++ + II + +M+ IL +A +GM++ Y
Sbjct: 182 FLISKDTLSVRMLD-DTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAY 240
Query: 255 YHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGL 314
Y +IFT L+ ++ VN+ GF I N + + E Q+ +S
Sbjct: 241 YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHA--------FFQEFAQSLNQSWQEN 292
Query: 315 LDGVMMT----DAALLYDAVHIVSVCYQ---RAPQMTVNSLQCHRHKAWRFGGRFMNFIK 367
D V T +ALL+DAV+ V Q R+ ++ V L C + W+ G MN+++
Sbjct: 293 CDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLR 352
Query: 368 EAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNV 427
+ EGLTG I FN + G R+++ L I+ +G ++G W A+GL++ N+
Sbjct: 353 MVELEGLTGHIEFN-SKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYAS--NI 409
Query: 428 TDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVE 487
+D+L N +L+VTT+LE P++M + + + + GNDR+EG+C+D+LKELA IL F+Y+IRLV
Sbjct: 410 SDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVG 469
Query: 488 DGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKP 547
DG YG + G W GMV ELI KADLAVA LTIT REK IDFSKPFMTLG+SILYR
Sbjct: 470 DGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVH 529
Query: 548 NGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG-SEVVEN 606
G P FSFL+P SP +W+++LLAYL VSCVLF++AR +PYEWY HPC G ++ N
Sbjct: 530 MGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVN 589
Query: 607 NFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERM 666
++L NS WF +G MQQGS + P+ALSTR + G+WW FTLIIISSYTANLAAFLTV+RM
Sbjct: 590 QYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRM 649
Query: 667 ESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSK-PSALVKNNEEG 725
+ PI+S DDLA QT IEYG + G++MTFF+ S+ T+++MW +M SK PS VK+ EEG
Sbjct: 650 DVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEG 709
Query: 726 IQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQ 785
I R L ++YA L+EST EY QRNCNLTQIGGL+D+KGYGIG P+GS +RD+ +AILQ
Sbjct: 710 IARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQ 769
Query: 786 LQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVY 845
LQE ++L I+K KWW G CP+EE+ A LG++ IGGIF+VL GL++++ +A+ EF++
Sbjct: 770 LQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLW 829
Query: 846 KLRKTAEREQRSFCSTVADEIRFSLTCQ--------RRVKHKPQPPM 884
LR +E + S C + E+R + CQ R P+PP+
Sbjct: 830 TLRH-SEATEVSVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPI 875
>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
sapiens]
Length = 906
Score = 606 bits (1562), Expect = e-173
Identities = 342/850 (40%), Positives = 513/850 (60%), Gaps = 51/850 (6%)
Query: 33 PHVIRIGGIFEYADGPNAQVMNAEEHA-FRFSANIINRNRTLLPNTTLTYDIQRIHFHDS 91
P+ I+IGG+F PN Q ++EHA FRF+ + + LLP I ++ DS
Sbjct: 22 PNNIQIGGLF-----PNQQ---SQEHAAFRFALSQLTEPPKLLPQ------IDIVNISDS 67
Query: 92 FEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVN 151
FE T + C Q + GV AIFG + N + S C AL V I + P+D + F +
Sbjct: 68 FEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSF---PVDTSNQFVLQ 124
Query: 152 LYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLK-IRQLPID 210
L P+ L A++ ++ + KW+ +YD GL LQ+++ + N ++ + L
Sbjct: 125 LRPE---LQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTT 181
Query: 211 SDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLE 270
+ R L +++++ +E ++ DC IL Q + + YH+I L +DL
Sbjct: 182 EEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLN 241
Query: 271 PYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAV 330
++ SG N+TGF+++N + + I+++W + R + + +AL YD V
Sbjct: 242 KFKESGANVTGFQLVNYTDTIPAKIMQQWK----NSDARDHTRVDWKRPKYTSALTYDGV 297
Query: 331 HIVSVCYQRAPQMTV------NSLQCHRHKA--WRFGGRFMNFIKEAQWEGLTGRIVFNK 382
+++ +Q + + N+ C + A W G +++ ++EGLTG + FN+
Sbjct: 298 KVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNE 357
Query: 383 TSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVL 442
G RT++ L +I +K DG+ K+G W+ D + + S+ NR+ IVTT+L
Sbjct: 358 -KGRRTNYTLHVIEMKHDGIRKIGYWNEDDKF-VPAATDAQAGGDNSSVQNRTYIVTTIL 415
Query: 443 EEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQD-DKGQWN 501
E+P+VM +K+ GNDR+EGYC++L E+A +G+SY + +V DGKYGA+D D WN
Sbjct: 416 EDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWN 475
Query: 502 GMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPL 561
GMV EL+ +AD+AVAPLTIT VRE+ IDFSKPFM+LG+SI+ +KP + P VFSFL+PL
Sbjct: 476 GMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPL 535
Query: 562 SPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVE---NNFTLLNSFWFGM 618
+ +IWM ++ AY+GVS VLF+++RFSPYEW+ + N F + NS WF +
Sbjct: 536 AYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSL 595
Query: 619 GSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAK 678
G+ MQQG ++ P++LS RI+GG+WWFFTLIIISSYTANLAAFLTVERM SPI+SA+DLAK
Sbjct: 596 GAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK 655
Query: 679 QTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSALVKNNEEGIQRALTA--DYA 735
QT+I YG ++ G+T FF++SKI+ FEKMW +M S++PS V+ EEG+ R + YA
Sbjct: 656 QTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYA 715
Query: 736 LLMESTTIEYVTQRN-CNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHI 794
L+EST EY+ QR C+ ++GG +DSKGYGI TP GS R+ + +A+L+L E+ L
Sbjct: 716 YLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDK 775
Query: 795 MKEKWWR-----GSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRK 849
+K KWW GSG + ++K SAL + + G+F +L GL L++LVA+ EF YK R
Sbjct: 776 LKNKWWYDKGECGSGGGDSKDK-TSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRS 834
Query: 850 TAEREQRSFC 859
++R + FC
Sbjct: 835 ESKR-MKGFC 843
>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
sapiens]
Length = 906
Score = 604 bits (1558), Expect = e-172
Identities = 340/849 (40%), Positives = 511/849 (60%), Gaps = 49/849 (5%)
Query: 33 PHVIRIGGIFEYADGPNAQVMNAEEHA-FRFSANIINRNRTLLPNTTLTYDIQRIHFHDS 91
P+ I+IGG+F PN Q ++EHA FRF+ + + LLP I ++ DS
Sbjct: 22 PNNIQIGGLF-----PNQQ---SQEHAAFRFALSQLTEPPKLLPQ------IDIVNISDS 67
Query: 92 FEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVN 151
FE T + C Q + GV AIFG + N + S C AL V I + P+D + F +
Sbjct: 68 FEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSF---PVDTSNQFVLQ 124
Query: 152 LYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLK-IRQLPID 210
L P+ L A++ ++ + KW+ +YD GL LQ+++ + N ++ + L
Sbjct: 125 LRPE---LQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTT 181
Query: 211 SDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLE 270
+ R L +++++ +E ++ DC IL Q + + YH+I L +DL
Sbjct: 182 EEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLN 241
Query: 271 PYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAV 330
++ SG N+TGF+++N + + I+++W + R + + +AL YD V
Sbjct: 242 KFKESGANVTGFQLVNYTDTIPAKIMQQWK----NSDARDHTRVDWKRPKYTSALTYDGV 297
Query: 331 HIVSVCYQRAPQMTV------NSLQCHRHKA--WRFGGRFMNFIKEAQWEGLTGRIVFNK 382
+++ +Q + + N+ C + A W G +++ ++EGLTG + FN+
Sbjct: 298 KVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNE 357
Query: 383 TSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVL 442
G RT++ L +I +K DG+ K+G W+ D + + S+ NR+ IVTT+L
Sbjct: 358 -KGRRTNYTLHVIEMKHDGIRKIGYWNEDDKF-VPAATDAQAGGDNSSVQNRTYIVTTIL 415
Query: 443 EEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQD-DKGQWN 501
E+P+VM +K+ GNDR+EGYC++L E+A +G+SY + +V DGKYGA+D D WN
Sbjct: 416 EDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWN 475
Query: 502 GMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPL 561
GMV EL+ +AD+AVAPLTIT VRE+ IDFSKPFM+LG+SI+ +KP + P VFSFL+PL
Sbjct: 476 GMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPL 535
Query: 562 SPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVE---NNFTLLNSFWFGM 618
+ +IWM ++ AY+GVS VLF+++RFSPYEW+ + N F + NS WF +
Sbjct: 536 AYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSL 595
Query: 619 GSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAK 678
G+ MQQG ++ P++LS RI+GG+WWFFTLIIISSYTANLAAFLTVERM SPI+SA+DLAK
Sbjct: 596 GAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK 655
Query: 679 QTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSALVKNNEEGIQRALTA--DYA 735
QT+I YG ++ G+T FF++SKI+ FEKMW +M S++PS V+ EEG+ R + YA
Sbjct: 656 QTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYA 715
Query: 736 LLMESTTIEYVTQRN-CNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHI 794
L+EST EY+ QR C+ ++GG +DSKGYGI TP GS R + +A+L+L E+ L
Sbjct: 716 YLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDK 775
Query: 795 MKEKWWRGSG-CPEEEN---KEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKT 850
+K KWW G C +++ + SAL + + G+F +L GL L++LVA+ EF YK R
Sbjct: 776 LKSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSE 835
Query: 851 AEREQRSFC 859
++R + FC
Sbjct: 836 SKR-MKGFC 843
>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
precursor [Homo sapiens]
Length = 883
Score = 595 bits (1534), Expect = e-170
Identities = 331/804 (41%), Positives = 484/804 (60%), Gaps = 45/804 (5%)
Query: 79 LTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWK 138
LT I + +SF T C Q + GV AIFG N + S C L H+
Sbjct: 58 LTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTL---HVSFITP 114
Query: 139 HHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELI--MAPS 196
P D F + + PD L A+L L++Y +W +YD GL LQ ++ A
Sbjct: 115 SFPTDGTHPFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEK 171
Query: 197 RYNIR-LKIRQLPIDSDDS--RPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTE 253
++ + + + + D D R L ++++ +E R+I DC I+ Q + +G +
Sbjct: 172 KWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVK 231
Query: 254 YYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESG 313
YH+I L DL ++ G N++GF+I++ D+ VS +E+WS + P G
Sbjct: 232 GYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYP----G 287
Query: 314 LLDGVMMTDAALLYDAVHIVSVCYQRAPQMTV------NSLQCHRHKA--WRFGGRFMNF 365
+ +AL YDAV +++ ++ + + N+ C + A W G
Sbjct: 288 AHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERA 347
Query: 366 IKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGL--NITEVAKGR 423
+K+ Q EGL+G I F++ +G R ++ ++I+ LK +G K+G WS D + +TE+ G
Sbjct: 348 LKQVQVEGLSGNIKFDQ-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSG- 405
Query: 424 GPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEI 483
N T L N++++VTT+LE P+VM +K+ L GN+R+EGYC+DL E+A GF Y++
Sbjct: 406 --NDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL 463
Query: 484 RLVEDGKYGAQD-DKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSI 542
+V DGKYGA+D D WNGMV EL+ KAD+A+APLTIT VRE+ IDFSKPFM+LG+SI
Sbjct: 464 TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISI 523
Query: 543 LYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSE 602
+ +KP + P VFSFL+PL+ +IWM ++ AY+GVS VLF+++RFSPYEW+ G E
Sbjct: 524 MIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH-TEEFEDGRE 582
Query: 603 VVE----NNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLA 658
N F + NS WF +G+ M+QG ++ P++LS RI+GG+WWFFTLIIISSYTANLA
Sbjct: 583 TQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLA 642
Query: 659 AFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSA 717
AFLTVERM SPI+SA+DL+KQT+I YG + G+T FF++SKI+ F+KMW +M S++PS
Sbjct: 643 AFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSV 702
Query: 718 LVKNNEEGIQRALTA--DYALLMESTTIEYVTQRN-CNLTQIGGLIDSKGYGIGTPMGSP 774
V+ EG+ R + YA L+EST EY+ QR C+ ++GG +DSKGYGI TP GS
Sbjct: 703 FVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSS 762
Query: 775 YRDKITIAILQLQEEDKLHIMKEKWWR-----GSGCPEEENKEASALGIQKIGGIFIVLA 829
R+ + +A+L+L E+ L +K KWW GSG + + K SAL + + G+F +L
Sbjct: 763 LRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEK-TSALSLSNVAGVFYILV 821
Query: 830 AGLVLSVLVAVGEFVYKLRKTAER 853
GL L++LVA+ EF YK R A+R
Sbjct: 822 GGLGLAMLVALIEFCYKSRAEAKR 845
>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
sapiens]
Length = 836
Score = 594 bits (1532), Expect = e-169
Identities = 329/803 (40%), Positives = 484/803 (60%), Gaps = 43/803 (5%)
Query: 79 LTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWK 138
LT I + +SF T C Q + GV AIFG N + S C L H+
Sbjct: 11 LTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTL---HVSFITP 67
Query: 139 HHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELI--MAPS 196
P D F + + PD L A+L L++Y +W +YD GL LQ ++ A
Sbjct: 68 SFPTDGTHPFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEK 124
Query: 197 RYNIR-LKIRQLPIDSDDS--RPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTE 253
++ + + + + D D R L ++++ +E R+I DC I+ Q + +G +
Sbjct: 125 KWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVK 184
Query: 254 YYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESG 313
YH+I L DL ++ G N++GF+I++ D+ VS +E+WS + P G
Sbjct: 185 GYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYP----G 240
Query: 314 LLDGVMMTDAALLYDAVHIVSVCYQRAPQMTV------NSLQCHRHKA--WRFGGRFMNF 365
+ +AL YDAV +++ ++ + + N+ C + A W G
Sbjct: 241 AHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERA 300
Query: 366 IKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGL--NITEVAKGR 423
+K+ Q EGL+G I F++ +G R ++ ++I+ LK +G K+G WS D + +TE+ G
Sbjct: 301 LKQVQVEGLSGNIKFDQ-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSG- 358
Query: 424 GPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEI 483
N T L N++++VTT+LE P+VM +K+ L GN+R+EGYC+DL E+A GF Y++
Sbjct: 359 --NDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL 416
Query: 484 RLVEDGKYGAQD-DKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSI 542
+V DGKYGA+D D WNGMV EL+ KAD+A+APLTIT VRE+ IDFSKPFM+LG+SI
Sbjct: 417 TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISI 476
Query: 543 LYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSE 602
+ +KP + P VFSFL+PL+ +IWM ++ AY+GVS VLF+++RFSPYEW+ G E
Sbjct: 477 MIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH-TEEFEDGRE 535
Query: 603 VVE----NNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLA 658
N F + NS WF +G+ M+QG ++ P++LS RI+GG+WWFFTLIIISSYTANLA
Sbjct: 536 TQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLA 595
Query: 659 AFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSA 717
AFLTVERM SPI+SA+DL+KQT+I YG + G+T FF++SKI+ F+KMW +M S++PS
Sbjct: 596 AFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSV 655
Query: 718 LVKNNEEGIQRALTA--DYALLMESTTIEYVTQRN-CNLTQIGGLIDSKGYGIGTPMGSP 774
V+ EG+ R + YA L+EST EY+ QR C+ ++GG +DSKGYGI TP GS
Sbjct: 656 FVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSS 715
Query: 775 YRDKITIAILQLQEEDKLHIMKEKWWRGSG-CPEEEN---KEASALGIQKIGGIFIVLAA 830
R + +A+L+L E+ L +K KWW G C +++ ++ SAL + + G+F +L
Sbjct: 716 LRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVG 775
Query: 831 GLVLSVLVAVGEFVYKLRKTAER 853
GL L++LVA+ EF YK R A+R
Sbjct: 776 GLGLAMLVALIEFCYKSRAEAKR 798
>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
precursor [Homo sapiens]
Length = 883
Score = 594 bits (1532), Expect = e-169
Identities = 329/803 (40%), Positives = 484/803 (60%), Gaps = 43/803 (5%)
Query: 79 LTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWK 138
LT I + +SF T C Q + GV AIFG N + S C L H+
Sbjct: 58 LTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTL---HVSFITP 114
Query: 139 HHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELI--MAPS 196
P D F + + PD L A+L L++Y +W +YD GL LQ ++ A
Sbjct: 115 SFPTDGTHPFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEK 171
Query: 197 RYNIR-LKIRQLPIDSDDS--RPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTE 253
++ + + + + D D R L ++++ +E R+I DC I+ Q + +G +
Sbjct: 172 KWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVK 231
Query: 254 YYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESG 313
YH+I L DL ++ G N++GF+I++ D+ VS +E+WS + P G
Sbjct: 232 GYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYP----G 287
Query: 314 LLDGVMMTDAALLYDAVHIVSVCYQRAPQMTV------NSLQCHRHKA--WRFGGRFMNF 365
+ +AL YDAV +++ ++ + + N+ C + A W G
Sbjct: 288 AHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERA 347
Query: 366 IKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGL--NITEVAKGR 423
+K+ Q EGL+G I F++ +G R ++ ++I+ LK +G K+G WS D + +TE+ G
Sbjct: 348 LKQVQVEGLSGNIKFDQ-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSG- 405
Query: 424 GPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEI 483
N T L N++++VTT+LE P+VM +K+ L GN+R+EGYC+DL E+A GF Y++
Sbjct: 406 --NDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL 463
Query: 484 RLVEDGKYGAQD-DKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSI 542
+V DGKYGA+D D WNGMV EL+ KAD+A+APLTIT VRE+ IDFSKPFM+LG+SI
Sbjct: 464 TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISI 523
Query: 543 LYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSE 602
+ +KP + P VFSFL+PL+ +IWM ++ AY+GVS VLF+++RFSPYEW+ G E
Sbjct: 524 MIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH-TEEFEDGRE 582
Query: 603 VVE----NNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLA 658
N F + NS WF +G+ M+QG ++ P++LS RI+GG+WWFFTLIIISSYTANLA
Sbjct: 583 TQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLA 642
Query: 659 AFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSA 717
AFLTVERM SPI+SA+DL+KQT+I YG + G+T FF++SKI+ F+KMW +M S++PS
Sbjct: 643 AFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSV 702
Query: 718 LVKNNEEGIQRALTA--DYALLMESTTIEYVTQRN-CNLTQIGGLIDSKGYGIGTPMGSP 774
V+ EG+ R + YA L+EST EY+ QR C+ ++GG +DSKGYGI TP GS
Sbjct: 703 FVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSS 762
Query: 775 YRDKITIAILQLQEEDKLHIMKEKWWRGSG-CPEEEN---KEASALGIQKIGGIFIVLAA 830
R + +A+L+L E+ L +K KWW G C +++ ++ SAL + + G+F +L
Sbjct: 763 LRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVG 822
Query: 831 GLVLSVLVAVGEFVYKLRKTAER 853
GL L++LVA+ EF YK R A+R
Sbjct: 823 GLGLAMLVALIEFCYKSRAEAKR 845
>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
precursor [Homo sapiens]
Length = 902
Score = 590 bits (1522), Expect = e-168
Identities = 337/879 (38%), Positives = 510/879 (58%), Gaps = 50/879 (5%)
Query: 19 LLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTT 78
LL FW P ++IGG+F + N ++ F I N + PN +
Sbjct: 10 LLFSGFWGLAMGAFPSSVQIGGLF---------IRNTDQEYTAFRLAIFLHNTS--PNAS 58
Query: 79 -----LTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHI 133
L + I +SF T C Q + GV AIFG + + S C+AL HI
Sbjct: 59 EAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSAL---HI 115
Query: 134 QLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIM 193
L P + + F + L P SL A+L L+ + +W +YD G LQ ++
Sbjct: 116 SLITPSFPTEGESQFVLQLRP---SLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIME 172
Query: 194 APSRYNIRLKIRQLPIDSDDS-RPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMT 252
+ + + +D S R LL+E+ R +E + + DC IL+Q +++G
Sbjct: 173 KAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHV 232
Query: 253 EYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSES 312
+ YH+I L + LE + + G N+TGF++++ + P V ++++W + P SE+
Sbjct: 233 KGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSET 292
Query: 313 GLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTV------NSLQCHRHKA--WRFGGRFMN 364
+AL YD V +++ ++ + + N+ C + A W G
Sbjct: 293 P-----PKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMER 347
Query: 365 FIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRG 424
+K+ + +GLTG + F+ G R ++ +D+ LK G KVG W+ D L + + G
Sbjct: 348 TLKQVRIQGLTGNVQFDHY-GRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLG 406
Query: 425 PNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIR 484
N T ++ NR+++VTT++E P+VM++K+ GND++EGYC+DL E+A +G Y+I
Sbjct: 407 -NDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIA 465
Query: 485 LVEDGKYGAQD-DKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSIL 543
+V DGKYGA+D D WNGMV EL+ KA++A+APLTIT VRE+ IDFSKPFM+LG+SI+
Sbjct: 466 IVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIM 525
Query: 544 YRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG--- 600
+KP + P VFSFL+PL+ +IWM ++ AY+GVS VLF+++RFSPYEW+ P +
Sbjct: 526 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGP 585
Query: 601 SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF 660
S+ N F + NS WF +G+ MQQG ++ P++LS RI+GG+WWFFTLIIISSYTANLAAF
Sbjct: 586 SDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 645
Query: 661 LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSALV 719
LTVERM SPI+SA+DLAKQT+I YG + G+T FF++SKI+ +EKMW +M S++PS
Sbjct: 646 LTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFT 705
Query: 720 KNNEEGIQRALTA--DYALLMESTTIEYVTQRN-CNLTQIGGLIDSKGYGIGTPMGSPYR 776
+ EG+ R + +A L+EST EY+ QR C+ ++GG +DSKGYG+ TP GS
Sbjct: 706 RTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLG 765
Query: 777 DKITIAILQLQEEDKLHIMKEKWWRGSG-CPEEEN---KEASALGIQKIGGIFIVLAAGL 832
+ +A+L+L E L +K KWW G C +++ + SAL + + G+F +L GL
Sbjct: 766 TPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGL 825
Query: 833 VLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLT 871
L++LVA+ EF YK R A+R + +F + ++ R S+T
Sbjct: 826 GLAMLVALIEFCYKSRAEAKRMKLTFSEAIRNKARLSIT 864
>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
precursor [Homo sapiens]
Length = 894
Score = 587 bits (1512), Expect = e-167
Identities = 337/854 (39%), Positives = 504/854 (59%), Gaps = 57/854 (6%)
Query: 31 GMPHVIRIGGIFEYADGPNAQVMNAEEH-AFRFSANIINRNRTLLPNTT-----LTYDIQ 84
G P+ I IGG+F +EH AFRF+ + N N+ NTT L Y +
Sbjct: 29 GFPNTISIGGLF--------MRNTVQEHSAFRFAVQLYNTNQ----NTTEKPFHLNYHVD 76
Query: 85 RIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDN 144
+ +SF T C Q + GV AIFG N + S C AL H P D
Sbjct: 77 HLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGAL---HTSFVTPSFPTDA 133
Query: 145 KDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKI 204
F + + P +L AIL L+ + KW +YD G LQ ++ A + N ++
Sbjct: 134 DVQFVIQMRP---ALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTA 190
Query: 205 RQLPI--DSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTL 262
R + D + R +++EM R +E R + DC IL+Q + +G + YH++ L
Sbjct: 191 RSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANL 250
Query: 263 DLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTD 322
+ LE + G N+TGF+I+N +NP V +++W + P +++ L
Sbjct: 251 GFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYT---- 306
Query: 323 AALLYDAVHIVSVCYQRAPQMTVNSLQ------CHRHKA--WRFGGRFMNFIKEAQWEGL 374
+AL +DA+ +++ ++ + V+ + C + A W G +K Q +G+
Sbjct: 307 SALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGM 366
Query: 375 TGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNR 434
TG I F+ T G RT++ +D+ +K G K G W+ + + + N + S NR
Sbjct: 367 TGNIQFD-TYGRRTNYTIDVYEMKVSGSRKAGYWNEYE--RFVPFSDQQISNDSASSENR 423
Query: 435 SLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQ 494
+++VTT+LE P+VM++K+ L GN+R+EGYC+DL E+A + Y++ +V DGKYGA+
Sbjct: 424 TIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGAR 483
Query: 495 DDKGQ-WNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPS 553
D + + WNGMV EL+ +AD+AVAPLTIT VRE+ IDFSKPFM+LG+SI+ +KP + P
Sbjct: 484 DPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG 543
Query: 554 VFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWY----DAHPCNPGSEV-VENNF 608
VFSFL+PL+ +IWM ++ AY+GVS VLF+++RFSPYEW+ + P +P S N F
Sbjct: 544 VFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEF 603
Query: 609 TLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMES 668
+ NS WF +G+ MQQG ++ P++LS RI+GG+WWFFTLIIISSYTANLAAFLTVERM S
Sbjct: 604 GIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVS 663
Query: 669 PIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSALVKNNEEGIQ 727
PI+SA+DLAKQT+I YG + G+T FF++SKI+ +EKMW++M S++PS K +G+
Sbjct: 664 PIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVA 723
Query: 728 RALTA--DYALLMESTTIEYVTQRN-CNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAIL 784
R + +A L+EST EY+ QR C+ ++GG +DSKGYG+ TP GS + + +A+L
Sbjct: 724 RVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVL 783
Query: 785 QLQEEDKLHIMKEKWWR-----GSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVA 839
+L E+ L +K KWW GSG + ++K SAL + + G+F +L GL L+++VA
Sbjct: 784 KLNEQGLLDKLKNKWWYDKGECGSGGGDSKDK-TSALSLSNVAGVFYILVGGLGLAMMVA 842
Query: 840 VGEFVYKLRKTAER 853
+ EF YK R ++R
Sbjct: 843 LIEFCYKSRAESKR 856
>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
precursor [Homo sapiens]
Length = 884
Score = 585 bits (1508), Expect = e-167
Identities = 335/862 (38%), Positives = 503/862 (58%), Gaps = 52/862 (6%)
Query: 19 LLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTT 78
LL FW P ++IGG+F + N ++ F I N + PN +
Sbjct: 10 LLFSGFWGLAMGAFPSSVQIGGLF---------IRNTDQEYTAFRLAIFLHNTS--PNAS 58
Query: 79 -----LTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHI 133
L + I +SF T C Q + GV AIFG + + S C+AL HI
Sbjct: 59 EAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSAL---HI 115
Query: 134 QLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIM 193
L P + + F + L P SL A+L L+ + +W +YD G LQ ++
Sbjct: 116 SLITPSFPTEGESQFVLQLRP---SLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIME 172
Query: 194 APSRYNIRLKIRQLPIDSDDS-RPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMT 252
+ + + +D S R LL+E+ R +E + + DC IL+Q +++G
Sbjct: 173 KAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHV 232
Query: 253 EYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSES 312
+ YH+I L + LE + + G N+TGF++++ + P V ++++W + P SE+
Sbjct: 233 KGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSET 292
Query: 313 GLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTV------NSLQCHRHKA--WRFGGRFMN 364
+AL YD V +++ ++ + + N+ C + A W G
Sbjct: 293 P-----PKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMER 347
Query: 365 FIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRG 424
+K+ + +GLTG + F+ G R ++ +D+ LK G KVG W+ D L + + G
Sbjct: 348 TLKQVRIQGLTGNVQFDHY-GRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLG 406
Query: 425 PNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIR 484
N T ++ NR+++VTT++E P+VM++K+ GND++EGYC+DL E+A +G Y+I
Sbjct: 407 -NDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIA 465
Query: 485 LVEDGKYGAQD-DKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSIL 543
+V DGKYGA+D D WNGMV EL+ KA++A+APLTIT VRE+ IDFSKPFM+LG+SI+
Sbjct: 466 IVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIM 525
Query: 544 YRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG--- 600
+KP + P VFSFL+PL+ +IWM ++ AY+GVS VLF+++RFSPYEW+ P +
Sbjct: 526 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGP 585
Query: 601 SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF 660
S+ N F + NS WF +G+ MQQG ++ P++LS RI+GG+WWFFTLIIISSYTANLAAF
Sbjct: 586 SDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 645
Query: 661 LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSALV 719
LTVERM SPI+SA+DLAKQT+I YG + G+T FF++SKI+ +EKMW +M S++PS
Sbjct: 646 LTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFT 705
Query: 720 KNNEEGIQRALTA--DYALLMESTTIEYVTQRN-CNLTQIGGLIDSKGYGIGTPMGSPYR 776
+ EG+ R + +A L+EST EY+ QR C+ ++GG +DSKGYG+ TP GS
Sbjct: 706 RTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLG 765
Query: 777 DKITIAILQLQEEDKLHIMKEKWWR-----GSGCPEEENKEASALGIQKIGGIFIVLAAG 831
+ + +A+L+L E+ L +K KWW GSG + ++K SAL + + G+F +L G
Sbjct: 766 NAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDK-TSALSLSNVAGVFYILVGG 824
Query: 832 LVLSVLVAVGEFVYKLRKTAER 853
L L++LVA+ EF YK R A+R
Sbjct: 825 LGLAMLVALIEFCYKSRAEAKR 846
>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
precursor [Homo sapiens]
Length = 894
Score = 584 bits (1506), Expect = e-166
Identities = 335/853 (39%), Positives = 502/853 (58%), Gaps = 55/853 (6%)
Query: 31 GMPHVIRIGGIFEYADGPNAQVMNAEEH-AFRFSANIINRNRTLLPNTT-----LTYDIQ 84
G P+ I IGG+F +EH AFRF+ + N N+ NTT L Y +
Sbjct: 29 GFPNTISIGGLF--------MRNTVQEHSAFRFAVQLYNTNQ----NTTEKPFHLNYHVD 76
Query: 85 RIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDN 144
+ +SF T C Q + GV AIFG N + S C AL H P D
Sbjct: 77 HLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGAL---HTSFVTPSFPTDA 133
Query: 145 KDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKI 204
F + + P +L AIL L+ + KW +YD G LQ ++ A + N ++
Sbjct: 134 DVQFVIQMRP---ALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTA 190
Query: 205 RQLPI--DSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTL 262
R + D + R +++EM R +E R + DC IL+Q + +G + YH++ L
Sbjct: 191 RSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANL 250
Query: 263 DLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTD 322
+ LE + G N+TGF+I+N +NP V +++W + P +++ L
Sbjct: 251 GFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYT---- 306
Query: 323 AALLYDAVHIVSVCYQRAPQMTVNSLQ------CHRHKA--WRFGGRFMNFIKEAQWEGL 374
+AL +DA+ +++ ++ + V+ + C + A W G +K Q +G+
Sbjct: 307 SALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGM 366
Query: 375 TGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNR 434
TG I F+ T G RT++ +D+ +K G K G W+ + + + N + S NR
Sbjct: 367 TGNIQFD-TYGRRTNYTIDVYEMKVSGSRKAGYWNEYE--RFVPFSDQQISNDSASSENR 423
Query: 435 SLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQ 494
+++VTT+LE P+VM++K+ L GN+R+EGYC+DL E+A + Y++ +V DGKYGA+
Sbjct: 424 TIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGAR 483
Query: 495 DDKGQ-WNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPS 553
D + + WNGMV EL+ +AD+AVAPLTIT VRE+ IDFSKPFM+LG+SI+ +KP + P
Sbjct: 484 DPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG 543
Query: 554 VFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWY----DAHPCNPGSEV-VENNF 608
VFSFL+PL+ +IWM ++ AY+GVS VLF+++RFSPYEW+ + P +P S N F
Sbjct: 544 VFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEF 603
Query: 609 TLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMES 668
+ NS WF +G+ MQQG ++ P++LS RI+GG+WWFFTLIIISSYTANLAAFLTVERM S
Sbjct: 604 GIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVS 663
Query: 669 PIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSALVKNNEEGIQ 727
PI+SA+DLAKQT+I YG + G+T FF++SKI+ +EKMW++M S++PS K +G+
Sbjct: 664 PIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVA 723
Query: 728 RALTA--DYALLMESTTIEYVTQRN-CNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAIL 784
R + +A L+EST EY+ QR C+ ++GG +DSKGYG+ TP GS + +A+L
Sbjct: 724 RVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVL 783
Query: 785 QLQEEDKLHIMKEKWWRGSG-CPEEEN---KEASALGIQKIGGIFIVLAAGLVLSVLVAV 840
+L E+ L +K KWW G C +++ + SAL + + G+F +L GL L+++VA+
Sbjct: 784 KLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVAL 843
Query: 841 GEFVYKLRKTAER 853
EF YK R ++R
Sbjct: 844 IEFCYKSRAESKR 856
>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
sapiens]
Length = 1009
Score = 360 bits (924), Expect = 3e-99
Identities = 269/906 (29%), Positives = 445/906 (49%), Gaps = 74/906 (8%)
Query: 35 VIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEA 94
+I IG IFE NA ++ F+ + + ++ N +L + +TY I+ I ++ F+A
Sbjct: 23 IIHIGAIFE----ENAA---KDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQA 75
Query: 95 TKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYP 154
++ACD + G++A+ + + NA+QS+ +A+ +PH+ ++ ++ + ++N P
Sbjct: 76 VQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQ-RNPGGSPRTACHLNPSP 134
Query: 155 DYAS----------LSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKI 204
D + L+ +L LV L+W+ + YD + LQ + SR + + +
Sbjct: 135 DGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSL 194
Query: 205 RQLPIDSDDSRPL--------LKEMKRGREF--RIIFDCSHTMAAQILKQAMAMGMMTEY 254
++ +D + S +E+ R R+ R I S A + +A+ + ++
Sbjct: 195 QK--VDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKD 252
Query: 255 YHFIFTTLDLYALDLEPYRYSGV-NLTGFR-ILNVDNPHVSAIVEKWSMERLQAAPRSES 312
H++F ++ ++ +S + +T R I + + L P +
Sbjct: 253 SHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDP--QE 310
Query: 313 GLLDGVMMTDAALLYDAVHIVSVCYQRAPQ----MTVNSLQCHRH--KAWRFGGRFMNFI 366
G L + +++ LYD+V +++ + R + ++ SL C R K W G ++ I
Sbjct: 311 GYLQMLQISN-LYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTI 369
Query: 367 KEAQWEGLTGRIVFNK-TSGLRTDFDLDIISLKE---DGLEKVGVWSPADGLNITEVAKG 422
K+ GLTG + F + +S F++ + E + K+ W GLN + +
Sbjct: 370 KKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERP 429
Query: 423 RGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYE 482
G L +L V TVLEEPFVM ++ L R++G+ ID+L LA LGF YE
Sbjct: 430 MG----SRLQGLTLKVVTVLEEPFVMV--AENILGQPKRYKGFSIDVLDALAKALGFKYE 483
Query: 483 IRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSI 542
I DG+YG Q WNGM+ ELI +ADLA++ +TIT RE +DFSK +M V I
Sbjct: 484 IYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGI 543
Query: 543 LYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSE 602
L +KP S+FS P +W + A V ++FV+ R A P +
Sbjct: 544 LIKKPE-EKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSAS 602
Query: 603 VVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLT 662
TL ++ W G+ +QQG E +++ RI+ G WW FTLI+ SSYTANLAAFLT
Sbjct: 603 A-----TLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLT 657
Query: 663 VERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKK------SKISTFEKMWAFMSSKPS 716
V RM++PI + DL+KQ ++ YG V+D A +F+ + STF ++W +S
Sbjct: 658 VSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGG 717
Query: 717 A--LVKNNEEGIQRALTADYALLMESTTIEY--VTQRNCNLTQIGGLIDSKGYGIGTPMG 772
A V + EGI++A +YA L + +EY +T +C++T IG I SKGYGI G
Sbjct: 718 ADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHG 777
Query: 773 SPYRDKITIAILQLQEEDKLHIMKEKWWRGSG-CPEEENKEASA----LGIQKIGGIFIV 827
SPYRD + IL+LQ+ L ++K+KWW G C + A A L + G+F +
Sbjct: 778 SPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCI 837
Query: 828 LAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEI--RFSLTCQRRVKHKPQPPMM 885
LA GL+L+ LVA E + + + + +++ R + + HK P
Sbjct: 838 LAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISPAS 897
Query: 886 VKTDAV 891
++ A+
Sbjct: 898 IELSAL 903
>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
Length = 1007
Score = 345 bits (886), Expect = 9e-95
Identities = 258/888 (29%), Positives = 426/888 (47%), Gaps = 82/888 (9%)
Query: 14 EYWAGLLVCAFWIP---DSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRN 70
E + LLV + W DS +I IG IF+ + ++ FR + +N+N
Sbjct: 2 EVFPFLLVLSVWWSRTWDSANADSIIHIGAIFD-------ESAKKDDEVFRTAVGDLNQN 54
Query: 71 RTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEV 130
+L +T+ + + ++ F+A ++AC+ + G++A+ + ++QS+ +A+ +
Sbjct: 55 EEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHI 114
Query: 131 PH--IQLRWKHHPLDNKDTFYVNLYPDYAS-------LSHAILDLVQYLKWRSATVVYDD 181
PH IQ P N DY L IL +V W+ + YD
Sbjct: 115 PHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDS 174
Query: 182 STGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLL------KEMKRGREF--RIIFDC 233
+ +QE + S+ + + ++++ + + L +E+ R R+ R I
Sbjct: 175 EYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVM 234
Query: 234 SHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDL-EPYRYSGVNLTGFRILNVDNPHV 292
+ A + + + ++ H+I ++ +D+ E R S LT R
Sbjct: 235 NPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIR-------QT 287
Query: 293 SAIVEKWSMERLQAAPRSESGLLDGV------MMTDAALLYDAVHIVSVCYQRAPQ---- 342
+ + S + R S L D M +YD V +++ + + +
Sbjct: 288 FPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKW 347
Query: 343 MTVNSLQCHRH--KAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGL-RTDFDLDIISLKE 399
++ SL C R K W+ G + IK+ GLTG + F + G F++ + E
Sbjct: 348 HSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGE 407
Query: 400 D---GLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTL 456
+ G+ K+G W+P GLN + K + +++ L V TVLEEPFVM S+ L
Sbjct: 408 ELGRGVRKLGCWNPVTGLNGSLTDK----KLENNMRGVVLRVVTVLEEPFVMV--SENVL 461
Query: 457 YGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAV 516
+++G+ ID+L L++ LGF+YEI + D KYG+ + G WNG+V EL+ +AD+ +
Sbjct: 462 GKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGI 521
Query: 517 APLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGV 576
+ LTIT RE +DF+ +M V +L R+ T +F+ L P +W + L V
Sbjct: 522 SALTITPDRENVVDFTTRYMDYSVGVLLRRAEKT-VDMFACLAPFDLSLWACIAGTVLLV 580
Query: 577 SCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTR 636
+++++ W + GS + TL NS WF GS +QQG E+ L+TR
Sbjct: 581 GLLVYLL------NWLNPPRLQMGSMT---STTLYNSMWFVYGSFVQQGGEVPYTTLATR 631
Query: 637 IIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFF 696
++ G WW F LI+ISSYTANLAAFLT+ R+ES I S DL+KQT+I YG V D A
Sbjct: 632 MMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHV 691
Query: 697 KKSKISTFEK------MWAFM--SSKPSALVKNNEEGIQRALTADYALLMESTTIEYV-- 746
+ ++ FE+ MW + S+ V ++ GIQ+ +YA + ++ +EYV
Sbjct: 692 RMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAI 751
Query: 747 TQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSG-- 804
+C+ IG + +GYGI GSPYRD + IL+LQ+ + I+K KWW +G
Sbjct: 752 NDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQC 811
Query: 805 ---CPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRK 849
+ ++ AL I+ G+F +LAAG+VLS +A+ E + RK
Sbjct: 812 DLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNKRK 859
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 248 bits (633), Expect = 2e-65
Identities = 220/821 (26%), Positives = 376/821 (45%), Gaps = 119/821 (14%)
Query: 149 YVNLYPDYASLSHAILDLVQYLKWRSATV-VYDDSTGLIRLQEL-IMAPSRYNIRLKIRQ 206
++ P Y+ S ++++ W + V DD G + L + R + K+ Q
Sbjct: 137 FLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQ 196
Query: 207 LPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYA 266
+ + LL E K II S AA + + A + M Y ++ ++
Sbjct: 197 FDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG 256
Query: 267 LDLEPYRYSGVNLTGFRILNVDNP--HVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAA 324
L RY+ + G +++N N H+S + + ++ LL+ +TD
Sbjct: 257 NAL---RYAPDGILGLQLINGKNESAHIS--------DAVGVVAQAVHELLEKENITDP- 304
Query: 325 LLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQW-EGLTGRIVFNKT 383
P+ V + W+ G F + +++ +G+TGR+ FN+
Sbjct: 305 ----------------PRGCVGNTNI-----WKTGPLFKRVLMSSKYADGVTGRVEFNE- 342
Query: 384 SGLRTDFDLDIISLKEDGLEKVGVWS-----PADGLNIT---EVAKGRGPNVTDSLTNRS 435
G R + I++L+ L +VG+++ P D I E K RG ++ L
Sbjct: 343 DGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLK--- 399
Query: 436 LIVTTVLEEPFVMFR--------KSDRTLYG-----------NDRFEG------------ 464
+ T+ +EPFV + K + T+ G ND G
Sbjct: 400 --IVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYG 457
Query: 465 YCIDLLKELAHILGFSYEIRLVEDGKYGAQD-----DKGQWNGMVKELIDHKADLAVAPL 519
+CIDLL +LA + F+YE+ LV DGK+G Q+ +K +WNGM+ EL+ +AD+ VAPL
Sbjct: 458 FCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPL 517
Query: 520 TITHVREKAIDFSKPFMTLGVSILYRK--PNGTNPSVFSFLNPLSPDIWMYVLLAYLGVS 577
TI + R + I+FSKPF G++IL +K P T + SF+ P +W+ V L+ V+
Sbjct: 518 TINNERAQYIEFSKPFKYQGLTILVKKEIPRST---LDSFMQPFQSTLWLLVGLSVHVVA 574
Query: 578 CVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQG-SELMPKALSTR 636
+L+++ RFSP+ + + E E+ TL ++ WF G L+ G E P++ S R
Sbjct: 575 VMLYLLDRFSPFGRFKVN----SEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSAR 630
Query: 637 IIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQT---KIEYGAVKDGATM 693
I+G +W F +II++SYTANLAAFL ++R E I +D + K Y VK +
Sbjct: 631 ILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVD 690
Query: 694 TFFKKS-KISTFEKMWAFMSSKPSALVKNNEEGIQRALTAD-----YALLMESTTIEYVT 747
+F++ ++ST M+ M K+N E A+ A +A + +S +E+
Sbjct: 691 IYFRRQVELST---MYRHME-------KHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA 740
Query: 748 QRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPE 807
+ C+L G L G+GIG SP++ ++++IL+ E + + + W R C
Sbjct: 741 SQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDS 800
Query: 808 EENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIR 867
N A+ L + + G+F+++A G+V + + E YK K A R+Q + R
Sbjct: 801 RSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWR 859
Query: 868 FSLTCQRRVKHKPQPPMMVKTDAVIN-MHTFNDRRLPGKDS 907
+L ++ + +P P A+ + + + RR KD+
Sbjct: 860 KNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT 900
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 244 bits (622), Expect = 3e-64
Identities = 211/768 (27%), Positives = 356/768 (46%), Gaps = 118/768 (15%)
Query: 149 YVNLYPDYASLSHAILDLVQYLKWRSATV-VYDDSTGLIRLQEL-IMAPSRYNIRLKIRQ 206
++ P Y+ S ++++ W + V DD G + L + R + K+ Q
Sbjct: 137 FLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQ 196
Query: 207 LPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYA 266
+ + LL E K II S AA + + A + M Y ++ ++
Sbjct: 197 FDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG 256
Query: 267 LDLEPYRYSGVNLTGFRILNVDNP--HVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAA 324
L RY+ + G +++N N H+S + + ++ LL+ +TD
Sbjct: 257 NAL---RYAPDGILGLQLINGKNESAHIS--------DAVGVVAQAVHELLEKENITDP- 304
Query: 325 LLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQW-EGLTGRIVFNKT 383
P+ V + W+ G F + +++ +G+TGR+ FN+
Sbjct: 305 ----------------PRGCVGNTNI-----WKTGPLFKRVLMSSKYADGVTGRVEFNE- 342
Query: 384 SGLRTDFDLDIISLKEDGLEKVGVWS-----PADGLNIT---EVAKGRGPNVTDSLTNRS 435
G R + I++L+ L +VG+++ P D I E K RG ++ L
Sbjct: 343 DGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLK--- 399
Query: 436 LIVTTVLEEPFVMFR--------KSDRTLYG-----------NDRFEG------------ 464
+ T+ +EPFV + K + T+ G ND G
Sbjct: 400 --IVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYG 457
Query: 465 YCIDLLKELAHILGFSYEIRLVEDGKYGAQD-----DKGQWNGMVKELIDHKADLAVAPL 519
+CIDLL +LA + F+YE+ LV DGK+G Q+ +K +WNGM+ EL+ +AD+ VAPL
Sbjct: 458 FCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPL 517
Query: 520 TITHVREKAIDFSKPFMTLGVSILYRK--PNGTNPSVFSFLNPLSPDIWMYVLLAYLGVS 577
TI + R + I+FSKPF G++IL +K P T + SF+ P +W+ V L+ V+
Sbjct: 518 TINNERAQYIEFSKPFKYQGLTILVKKEIPRST---LDSFMQPFQSTLWLLVGLSVHVVA 574
Query: 578 CVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQG-SELMPKALSTR 636
+L+++ RFSP+ + + E E+ TL ++ WF G L+ G E P++ S R
Sbjct: 575 VMLYLLDRFSPFGRFKVN----SEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSAR 630
Query: 637 IIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQT---KIEYGAVKDGATM 693
I+G +W F +II++SYTANLAAFL ++R E I +D + K Y VK +
Sbjct: 631 ILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVD 690
Query: 694 TFFKKS-KISTFEKMWAFMSSKPSALVKNNEEGIQRALTAD-----YALLMESTTIEYVT 747
+F++ ++ST M+ M K+N E A+ A +A + +S +E+
Sbjct: 691 IYFRRQVELST---MYRHME-------KHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA 740
Query: 748 QRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPE 807
+ C+L G L G+GIG SP++ ++++IL+ E + + + W R C
Sbjct: 741 SQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDS 800
Query: 808 EENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQ 855
N A+ L + + G+F+++A G+V + + E YK K A R+Q
Sbjct: 801 RSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQ 847
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 244 bits (622), Expect = 3e-64
Identities = 211/768 (27%), Positives = 356/768 (46%), Gaps = 118/768 (15%)
Query: 149 YVNLYPDYASLSHAILDLVQYLKWRSATV-VYDDSTGLIRLQEL-IMAPSRYNIRLKIRQ 206
++ P Y+ S ++++ W + V DD G + L + R + K+ Q
Sbjct: 137 FLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQ 196
Query: 207 LPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYA 266
+ + LL E K II S AA + + A + M Y ++ ++
Sbjct: 197 FDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG 256
Query: 267 LDLEPYRYSGVNLTGFRILNVDNP--HVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAA 324
L RY+ + G +++N N H+S + + ++ LL+ +TD
Sbjct: 257 NAL---RYAPDGILGLQLINGKNESAHIS--------DAVGVVAQAVHELLEKENITDP- 304
Query: 325 LLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQW-EGLTGRIVFNKT 383
P+ V + W+ G F + +++ +G+TGR+ FN+
Sbjct: 305 ----------------PRGCVGNTNI-----WKTGPLFKRVLMSSKYADGVTGRVEFNE- 342
Query: 384 SGLRTDFDLDIISLKEDGLEKVGVWS-----PADGLNIT---EVAKGRGPNVTDSLTNRS 435
G R + I++L+ L +VG+++ P D I E K RG ++ L
Sbjct: 343 DGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLK--- 399
Query: 436 LIVTTVLEEPFVMFR--------KSDRTLYG-----------NDRFEG------------ 464
+ T+ +EPFV + K + T+ G ND G
Sbjct: 400 --IVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYG 457
Query: 465 YCIDLLKELAHILGFSYEIRLVEDGKYGAQD-----DKGQWNGMVKELIDHKADLAVAPL 519
+CIDLL +LA + F+YE+ LV DGK+G Q+ +K +WNGM+ EL+ +AD+ VAPL
Sbjct: 458 FCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPL 517
Query: 520 TITHVREKAIDFSKPFMTLGVSILYRK--PNGTNPSVFSFLNPLSPDIWMYVLLAYLGVS 577
TI + R + I+FSKPF G++IL +K P T + SF+ P +W+ V L+ V+
Sbjct: 518 TINNERAQYIEFSKPFKYQGLTILVKKEIPRST---LDSFMQPFQSTLWLLVGLSVHVVA 574
Query: 578 CVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQG-SELMPKALSTR 636
+L+++ RFSP+ + + E E+ TL ++ WF G L+ G E P++ S R
Sbjct: 575 VMLYLLDRFSPFGRFKVN----SEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSAR 630
Query: 637 IIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQT---KIEYGAVKDGATM 693
I+G +W F +II++SYTANLAAFL ++R E I +D + K Y VK +
Sbjct: 631 ILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVD 690
Query: 694 TFFKKS-KISTFEKMWAFMSSKPSALVKNNEEGIQRALTAD-----YALLMESTTIEYVT 747
+F++ ++ST M+ M K+N E A+ A +A + +S +E+
Sbjct: 691 IYFRRQVELST---MYRHME-------KHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA 740
Query: 748 QRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPE 807
+ C+L G L G+GIG SP++ ++++IL+ E + + + W R C
Sbjct: 741 SQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDS 800
Query: 808 EENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQ 855
N A+ L + + G+F+++A G+V + + E YK K A R+Q
Sbjct: 801 RSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQ 847
>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
[Homo sapiens]
Length = 1336
Score = 185 bits (469), Expect = 2e-46
Identities = 125/400 (31%), Positives = 211/400 (52%), Gaps = 38/400 (9%)
Query: 463 EGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTIT 522
+G+CID+LK LAH +GFSY++ LV +GK+G + D G WNGM+ E+ +AD+A+ LTI
Sbjct: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKID-GVWNGMIGEVFYQRADMAIGSLTIN 543
Query: 523 HVREKAIDFSKPFMTLGVSILYRKPNGT-NPSVFSFLNPLSPDIWMYVLLAYLGVSCV-L 580
R + +DFS PF+ G+S++ + NGT +PS +FL P SP +W+ + + L V V +
Sbjct: 544 EERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMMFVMCLTVVAVTV 601
Query: 581 FVIARFSP--YEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSEL-MPKALSTRI 637
F+ SP Y A PG + FT+ S W + + P+ +++I
Sbjct: 602 FIFEYLSPVGYNRSLATGKRPGG----STFTIGKSIWLLWALVFNNSVPVENPRGTTSKI 657
Query: 638 IGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ------TKIEYGAVKDGA 691
+ +W FF +I ++SYTANLAAF+ E + D Q +++G V +G+
Sbjct: 658 MVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGS 717
Query: 692 TMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADY-----ALLMESTTIEYV 746
T +K+ S + M ++M V+ N+ ++ ALT A + ++ + Y+
Sbjct: 718 T----EKNIRSNYPDMHSYM-------VRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYM 766
Query: 747 TQRN--CNLTQIGG--LIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRG 802
+++ C L IG + + GYGI GS ++ I +A+LQ +D++ +++ W G
Sbjct: 767 ARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSG 826
Query: 803 SGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGE 842
++ +S L I + G+F +L + LS+LV E
Sbjct: 827 ICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWE 866
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 183 bits (464), Expect = 7e-46
Identities = 175/678 (25%), Positives = 307/678 (45%), Gaps = 98/678 (14%)
Query: 220 EMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRY-SGVN 278
++K+ I+ CS A IL +A ++G+ + +I +L +L P + SG+
Sbjct: 218 QLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGL- 276
Query: 279 LTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCY- 337
+S + W L+A R G+L + + CY
Sbjct: 277 -------------ISVSYDDWDYS-LEARVRDGIGILTTAASSMLEKFSYIPEAKASCYG 322
Query: 338 -QRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIIS 396
P++ +++L F+ W+G + F + G + L +I
Sbjct: 323 QMERPEVPMHTLH--------------PFMVNVTWDGKD--LSFTE-EGYQVHPRLVVIV 365
Query: 397 LKEDG-LEKVGVWSPADGLNITEVAKGRGPNVTD-SLTNRSLIVTTVLEEPFVMFRKSD- 453
L +D EKVG W L++ R + +D + L + T+ E PFV+ D
Sbjct: 366 LNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDP 424
Query: 454 ------RTLYGNDRF-----------------EGYCIDLLKELAHILGFSYEIRLVEDGK 490
R +F +G+CID+LK+L+ + F+Y++ LV +GK
Sbjct: 425 LTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGK 484
Query: 491 YGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGT 550
+G + + WNGM+ E++ +A +AV LTI R + +DFS PF+ G+S++ + NGT
Sbjct: 485 HGKKVNN-VWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGT 543
Query: 551 -NPSVFSFLNPLSPDIWMYVLLAYLGVSCV-LFVIARFSPYEWYDAHPCNPGSEVVENNF 608
+PS +FL P S +W+ + + L VS + +FV FSP + G +F
Sbjct: 544 VSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGY--NRNLAKGKAPHGPSF 599
Query: 609 TLLNSFWFGMGSLMQQGSELM-PKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERME 667
T+ + W G + + PK +++I+ +W FF +I ++SYTANLAAF+ E
Sbjct: 600 TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFV 659
Query: 668 SPIDSADDLAKQTKIEY------GAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKN 721
+ D Q +Y G V +G+T +++ + + M +M+ K
Sbjct: 660 DQVTGLSDKKFQRPHDYSPPFRFGTVPNGST----ERNIRNNYPYMHQYMT-------KF 708
Query: 722 NEEGIQRALTADY-----ALLMESTTIEYVTQRN--CNLTQIGG--LIDSKGYGIGTPMG 772
N++G++ AL + A + ++ + Y R+ C L IG + + GYGI G
Sbjct: 709 NQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKG 768
Query: 773 SPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGL 832
SP++ +I +A+LQ + ++ ++ W G E+ +S L I + G+F +LAA +
Sbjct: 769 SPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAM 828
Query: 833 VLSVLVAVGE--FVYKLR 848
LS++ + E F +KLR
Sbjct: 829 ALSLITFIWEHLFYWKLR 846
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 183 bits (464), Expect = 7e-46
Identities = 175/678 (25%), Positives = 307/678 (45%), Gaps = 98/678 (14%)
Query: 220 EMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRY-SGVN 278
++K+ I+ CS A IL +A ++G+ + +I +L +L P + SG+
Sbjct: 218 QLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGL- 276
Query: 279 LTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCY- 337
+S + W L+A R G+L + + CY
Sbjct: 277 -------------ISVSYDDWDYS-LEARVRDGIGILTTAASSMLEKFSYIPEAKASCYG 322
Query: 338 -QRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIIS 396
P++ +++L F+ W+G + F + G + L +I
Sbjct: 323 QMERPEVPMHTLH--------------PFMVNVTWDGKD--LSFTE-EGYQVHPRLVVIV 365
Query: 397 LKEDG-LEKVGVWSPADGLNITEVAKGRGPNVTD-SLTNRSLIVTTVLEEPFVMFRKSD- 453
L +D EKVG W L++ R + +D + L + T+ E PFV+ D
Sbjct: 366 LNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDP 424
Query: 454 ------RTLYGNDRF-----------------EGYCIDLLKELAHILGFSYEIRLVEDGK 490
R +F +G+CID+LK+L+ + F+Y++ LV +GK
Sbjct: 425 LTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGK 484
Query: 491 YGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGT 550
+G + + WNGM+ E++ +A +AV LTI R + +DFS PF+ G+S++ + NGT
Sbjct: 485 HGKKVNN-VWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGT 543
Query: 551 -NPSVFSFLNPLSPDIWMYVLLAYLGVSCV-LFVIARFSPYEWYDAHPCNPGSEVVENNF 608
+PS +FL P S +W+ + + L VS + +FV FSP + G +F
Sbjct: 544 VSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGY--NRNLAKGKAPHGPSF 599
Query: 609 TLLNSFWFGMGSLMQQGSELM-PKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERME 667
T+ + W G + + PK +++I+ +W FF +I ++SYTANLAAF+ E
Sbjct: 600 TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFV 659
Query: 668 SPIDSADDLAKQTKIEY------GAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKN 721
+ D Q +Y G V +G+T +++ + + M +M+ K
Sbjct: 660 DQVTGLSDKKFQRPHDYSPPFRFGTVPNGST----ERNIRNNYPYMHQYMT-------KF 708
Query: 722 NEEGIQRALTADY-----ALLMESTTIEYVTQRN--CNLTQIGG--LIDSKGYGIGTPMG 772
N++G++ AL + A + ++ + Y R+ C L IG + + GYGI G
Sbjct: 709 NQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKG 768
Query: 773 SPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGL 832
SP++ +I +A+LQ + ++ ++ W G E+ +S L I + G+F +LAA +
Sbjct: 769 SPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAM 828
Query: 833 VLSVLVAVGE--FVYKLR 848
LS++ + E F +KLR
Sbjct: 829 ALSLITFIWEHLFYWKLR 846
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 183 bits (464), Expect = 7e-46
Identities = 175/678 (25%), Positives = 307/678 (45%), Gaps = 98/678 (14%)
Query: 220 EMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRY-SGVN 278
++K+ I+ CS A IL +A ++G+ + +I +L +L P + SG+
Sbjct: 218 QLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGL- 276
Query: 279 LTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCY- 337
+S + W L+A R G+L + + CY
Sbjct: 277 -------------ISVSYDDWDYS-LEARVRDGIGILTTAASSMLEKFSYIPEAKASCYG 322
Query: 338 -QRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIIS 396
P++ +++L F+ W+G + F + G + L +I
Sbjct: 323 QMERPEVPMHTLH--------------PFMVNVTWDGKD--LSFTE-EGYQVHPRLVVIV 365
Query: 397 LKEDG-LEKVGVWSPADGLNITEVAKGRGPNVTD-SLTNRSLIVTTVLEEPFVMFRKSD- 453
L +D EKVG W L++ R + +D + L + T+ E PFV+ D
Sbjct: 366 LNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDP 424
Query: 454 ------RTLYGNDRF-----------------EGYCIDLLKELAHILGFSYEIRLVEDGK 490
R +F +G+CID+LK+L+ + F+Y++ LV +GK
Sbjct: 425 LTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGK 484
Query: 491 YGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGT 550
+G + + WNGM+ E++ +A +AV LTI R + +DFS PF+ G+S++ + NGT
Sbjct: 485 HGKKVNN-VWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGT 543
Query: 551 -NPSVFSFLNPLSPDIWMYVLLAYLGVSCV-LFVIARFSPYEWYDAHPCNPGSEVVENNF 608
+PS +FL P S +W+ + + L VS + +FV FSP + G +F
Sbjct: 544 VSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGY--NRNLAKGKAPHGPSF 599
Query: 609 TLLNSFWFGMGSLMQQGSELM-PKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERME 667
T+ + W G + + PK +++I+ +W FF +I ++SYTANLAAF+ E
Sbjct: 600 TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFV 659
Query: 668 SPIDSADDLAKQTKIEY------GAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKN 721
+ D Q +Y G V +G+T +++ + + M +M+ K
Sbjct: 660 DQVTGLSDKKFQRPHDYSPPFRFGTVPNGST----ERNIRNNYPYMHQYMT-------KF 708
Query: 722 NEEGIQRALTADY-----ALLMESTTIEYVTQRN--CNLTQIGG--LIDSKGYGIGTPMG 772
N++G++ AL + A + ++ + Y R+ C L IG + + GYGI G
Sbjct: 709 NQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKG 768
Query: 773 SPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGL 832
SP++ +I +A+LQ + ++ ++ W G E+ +S L I + G+F +LAA +
Sbjct: 769 SPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAM 828
Query: 833 VLSVLVAVGE--FVYKLR 848
LS++ + E F +KLR
Sbjct: 829 ALSLITFIWEHLFYWKLR 846
>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
[Homo sapiens]
Length = 1484
Score = 181 bits (460), Expect = 2e-45
Identities = 143/497 (28%), Positives = 240/497 (48%), Gaps = 64/497 (12%)
Query: 394 IISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSD 453
I+ KE E+VG W L + R T+ + L + T+ E PFV+ D
Sbjct: 365 ILLNKERKWERVGKWKDKS-LQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVD 423
Query: 454 ---------------RTLYGNDRFE----------GYCIDLLKELAHILGFSYEIRLVED 488
R + N E G+CID+LK+++ + F+Y++ LV +
Sbjct: 424 PLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN 483
Query: 489 GKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPN 548
GK+G + + G WNGM+ E++ +A +AV LTI R + +DFS PF+ G+S++ + N
Sbjct: 484 GKHGKKIN-GTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSN 542
Query: 549 GT-NPSVFSFLNPLSPDIWMYVLLAYLGVSCV-LFVIARFSP--YEWYDAHPCNPGSEVV 604
GT +PS +FL P S D+W+ + + L VS V +FV FSP Y A PG
Sbjct: 543 GTVSPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGP-- 598
Query: 605 ENNFTLLNSFWFGMGSLMQQGSELM-PKALSTRIIGGIWWFFTLIIISSYTANLAAFLTV 663
+FT+ + W G + + PK +++I+ +W FF +I ++SYTANLAAF+
Sbjct: 599 --SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQ 656
Query: 664 ERMESPIDSADDLAKQ------TKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSA 717
E + D Q +G V +G+T +++ + + +M A+M
Sbjct: 657 EEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGST----ERNIRNNYAEMHAYMG----- 707
Query: 718 LVKNNEEGIQRALTADY-----ALLMESTTIEYVTQRN--CNLTQIGG--LIDSKGYGIG 768
K N+ G+ AL + A + ++ + Y+ R+ C L IG + S GYGI
Sbjct: 708 --KFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIA 765
Query: 769 TPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVL 828
S ++ ++ +AILQL + ++ ++ W G E+ +S L I + G+F +L
Sbjct: 766 IQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYML 825
Query: 829 AAGLVLSVLVAVGEFVY 845
A + LS++ + E ++
Sbjct: 826 GAAMALSLITFICEHLF 842
>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
[Homo sapiens]
Length = 1233
Score = 172 bits (435), Expect = 2e-42
Identities = 156/576 (27%), Positives = 261/576 (45%), Gaps = 71/576 (12%)
Query: 362 FMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGL-EKVGVWSPADGLNITEVA 420
F + WEG R G + +I+L L E VG W V
Sbjct: 331 FYRHLLNVTWEG---RDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRWEHGVLYMKYPVW 387
Query: 421 KGRGPNVTDSLTNRSLIVTTVLEEPFVMF------------------RKSDRTLYGNDRF 462
++ + +R L V T+ E PFV+ R+S+ T D
Sbjct: 388 PRYSASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVA 447
Query: 463 -------EGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLA 515
+G+CID+LK+LA ++ FSY++ LV +GK+G + +G WNGM+ E+ +AD+A
Sbjct: 448 PYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRV-RGVWNGMIGEVYYKRADMA 506
Query: 516 VAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGT-NPSVFSFLNPLSPDIWMYVLLAYL 574
+ LTI R + +DFS PF+ G+S++ + NGT +PS +FL P SP +W+ + + L
Sbjct: 507 IGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMMFVMCL 564
Query: 575 GVSCV-LFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSEL-MPKA 632
V + +F+ FSP + G + FT+ S W + + P+
Sbjct: 565 TVVAITVFMFEYFSPVSY--NQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRG 622
Query: 633 LSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ------TKIEYGA 686
+++I+ +W FF +I ++SYTANLAAF+ E+ + D Q +G
Sbjct: 623 TTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGT 682
Query: 687 VKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADY-----ALLMEST 741
V +G+T +++ S + M M VK N+ ++ ALT+ A + ++
Sbjct: 683 VPNGST----ERNIRSNYRDMHTHM-------VKFNQRSVEDALTSLKMGKLDAFIYDAA 731
Query: 742 TIEYVTQRN--CNLTQIGG--LIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKE 797
+ Y+ ++ C L IG + + GYGI S ++ I +A+LQ + + ++
Sbjct: 732 VLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLET 791
Query: 798 KWWRGSGCPEEENK-EASALGIQKIGGIFIVLAAGLVLSVLVAVGEFV--YKLRKTA-ER 853
W G C E+N+ +S L I + G+F +L + L++LV E + +KLR +
Sbjct: 792 VWLSGI-CQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNS 850
Query: 854 EQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTD 889
Q F + R +C V+ PP D
Sbjct: 851 SQLDFLLAFS---RGIYSCFSGVQSLASPPRQASPD 883
>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
[Homo sapiens]
Length = 1043
Score = 154 bits (389), Expect = 4e-37
Identities = 139/536 (25%), Positives = 225/536 (41%), Gaps = 65/536 (12%)
Query: 360 GRFM-NFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKED-----GLEKVGVWSPADG 413
GRF+ F+ ++G TG + +S + + SL+ D VG W DG
Sbjct: 335 GRFLARFLANTSFQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWR--DG 392
Query: 414 LNITEV--AKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLY-----------GND 460
E A R P + L V T+LE PFV R D ND
Sbjct: 393 QLDLEPGGASARPPPPQGAQVWPKLRVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTND 452
Query: 461 RFE----------------------GYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKG 498
GYCIDLL+ LA F +E+ LV DGKYGA D G
Sbjct: 453 SATLDALFAALANGSAPRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALRD-G 511
Query: 499 QWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFL 558
+W G+V +L+ +A +AV +I R + +DF+ PF + + I+ R + +P + +F+
Sbjct: 512 RWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFM 570
Query: 559 NPLSPDIWMYVLLAYLGVSCVLFVIARF-SPYEWYDAHPCNPGSEVVENNFTLLNSFWFG 617
PL W LGV L + A F + YEW + P F+ ++
Sbjct: 571 WPLHWSTW-------LGVFAALHLTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLC 623
Query: 618 MGSLMQQG-SELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL 676
L ++ S PK + R++ +W F L+++SSYTANLAA + ++ + D
Sbjct: 624 YAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDP 683
Query: 677 AKQTKIE---YGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTAD 733
+ +G V + + + KKS F M A M + +
Sbjct: 684 KLHHPAQGFRFGTVWESSAEAYIKKS----FPDMHAHMRRHSAPTTPRGVAMLTSDPPKL 739
Query: 734 YALLMESTTIEYVT--QRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDK 791
A +M+ + ++Y +C L +G +GYGIG P SP ++ I + +
Sbjct: 740 NAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGF 799
Query: 792 LHIMKEKWWRGSGCPEE--ENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVY 845
+ ++ +KW++ C + E + I G+F++L GL ++L ++GE +
Sbjct: 800 IDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAF 855
>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate
3A [Homo sapiens]
Length = 1115
Score = 153 bits (387), Expect = 6e-37
Identities = 111/394 (28%), Positives = 190/394 (48%), Gaps = 23/394 (5%)
Query: 464 GYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITH 523
GYCIDLL+++A + F +++ +V DGKYGA + G W G+V +L+ A +AV +I
Sbjct: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKN-GHWTGLVGDLLRGTAHMAVTSFSINT 636
Query: 524 VREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVI 583
R + IDF+ PF + + IL R + P + +F+ PL +W+ + +A L ++ V +
Sbjct: 637 ARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWLGIFVA-LHITAVFLTL 694
Query: 584 ARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELM-PKALSTRIIGGIW 642
YEW P F+ ++ L + + PK + R + +W
Sbjct: 695 -----YEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLW 749
Query: 643 WFFTLIIISSYTANLAAFLTVERMESPIDSADDLA---KQTKIEYGAVKDGATMTFFKKS 699
F + +S+YTANLAA + E++ + D +G V++ + + ++S
Sbjct: 750 AIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQS 809
Query: 700 KISTFEKMWAF-MSSKPSAL--VKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQI 756
E M + + + P + +KN+ E + A D ALL +I+ +C L +
Sbjct: 810 FPEMHEYMRRYNVPATPDGVEYLKNDPEKLD-AFIMDKALLDYEVSID----ADCKLLTV 864
Query: 757 GGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEE--NKEAS 814
G +GYGIG P SP I+ I Q + + ++ +KW+R C + E
Sbjct: 865 GKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETL 924
Query: 815 ALGIQKIGGIFIVLAAGLVLSVLVAVGE-FVYKL 847
+GI+ G+F++L G LS+L +GE VY+L
Sbjct: 925 QMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRL 958
>gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3
precursor [Homo sapiens]
Length = 433
Score = 151 bits (381), Expect = 3e-36
Identities = 117/438 (26%), Positives = 201/438 (45%), Gaps = 38/438 (8%)
Query: 19 LLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTT 78
LL FW P ++IGG+F + N ++ F I N + PN +
Sbjct: 10 LLFSGFWGLAMGAFPSSVQIGGLF---------IRNTDQEYTAFRLAIFLHNTS--PNAS 58
Query: 79 -----LTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHI 133
L + I +SF T C Q + GV AIFG + + S C+AL HI
Sbjct: 59 EAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSAL---HI 115
Query: 134 QLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIM 193
L P + + F + L P SL A+L L+ + +W +YD G LQ ++
Sbjct: 116 SLITPSFPTEGESQFVLQLRP---SLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIME 172
Query: 194 APSRYNIRLKIRQLPIDSDDS-RPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMT 252
+ + + +D S R LL+E+ R +E + + DC IL+Q +++G
Sbjct: 173 KAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHV 232
Query: 253 EYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSES 312
+ YH+I L + LE + + G N+TGF++++ + P V ++++W + P SE+
Sbjct: 233 KGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSET 292
Query: 313 GLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTV------NSLQCHRHKA--WRFGGRFMN 364
+AL YD V +++ ++ + + N+ C + A W G
Sbjct: 293 -----PPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMER 347
Query: 365 FIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRG 424
+K+ + +GLTG + F+ G R ++ +D+ LK G KVG W+ D L + + G
Sbjct: 348 TLKQVRIQGLTGNVQFDH-YGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLG 406
Query: 425 PNVTDSLTNRSLIVTTVL 442
N T ++ NR+++VTT++
Sbjct: 407 -NDTAAIENRTVVVTTIM 423
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,493,177
Number of Sequences: 37866
Number of extensions: 1437020
Number of successful extensions: 2878
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2638
Number of HSP's gapped (non-prelim): 49
length of query: 919
length of database: 18,247,518
effective HSP length: 111
effective length of query: 808
effective length of database: 14,044,392
effective search space: 11347868736
effective search space used: 11347868736
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.