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Search of human proteins with 28557781
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28557781 protein kinase C, eta [Homo sapiens]
(683 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28557781 protein kinase C, eta [Homo sapiens] 1422 0.0
gi|4885563 protein kinase C, epsilon [Homo sapiens] 917 0.0
gi|47157325 protein kinase C, delta [Homo sapiens] 556 e-158
gi|31377782 protein kinase C, delta [Homo sapiens] 556 e-158
gi|5453976 protein kinase C, theta [Homo sapiens] 541 e-154
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 410 e-114
gi|4506067 protein kinase C, alpha [Homo sapiens] 404 e-112
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 402 e-112
gi|133908623 protein kinase C, iota [Homo sapiens] 392 e-109
gi|13384594 protein kinase C, gamma [Homo sapiens] 384 e-106
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 380 e-105
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 356 4e-98
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 356 4e-98
gi|5453974 protein kinase N2 [Homo sapiens] 332 5e-91
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 328 1e-89
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 328 1e-89
gi|4502023 AKT2 kinase [Homo sapiens] 326 4e-89
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 325 9e-89
gi|62241015 AKT1 kinase [Homo sapiens] 324 1e-88
gi|62241013 AKT1 kinase [Homo sapiens] 324 1e-88
gi|62241011 AKT1 kinase [Homo sapiens] 324 1e-88
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 323 2e-88
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 289 7e-78
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 289 7e-78
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 288 2e-77
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 288 2e-77
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 286 6e-77
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 286 6e-77
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 286 6e-77
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 286 6e-77
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 1422 bits (3681), Expect = 0.0
Identities = 683/683 (100%), Positives = 683/683 (100%)
Query: 1 MSSGTMKFNGYLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTSTK 60
MSSGTMKFNGYLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTSTK
Sbjct: 1 MSSGTMKFNGYLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTSTK 60
Query: 61 QKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFEG 120
QKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFEG
Sbjct: 61 QKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFEG 120
Query: 121 WVDLEPEGKVFVVITLTGSFTEATLQRDRIFKHFTRKRQRAMRRRVHQINGHKFMATYLR 180
WVDLEPEGKVFVVITLTGSFTEATLQRDRIFKHFTRKRQRAMRRRVHQINGHKFMATYLR
Sbjct: 121 WVDLEPEGKVFVVITLTGSFTEATLQRDRIFKHFTRKRQRAMRRRVHQINGHKFMATYLR 180
Query: 181 QPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIAEQRF 240
QPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIAEQRF
Sbjct: 181 QPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIAEQRF 240
Query: 241 GINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAV 300
GINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAV
Sbjct: 241 GINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAV 300
Query: 301 ELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRV 360
ELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRV
Sbjct: 301 ELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRV 360
Query: 361 LGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF 420
LGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF
Sbjct: 361 LGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF 420
Query: 421 CCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDL 480
CCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDL
Sbjct: 421 CCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDL 480
Query: 481 KLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAM 540
KLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAM
Sbjct: 481 KLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAM 540
Query: 541 GVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSL 600
GVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSL
Sbjct: 541 GVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSL 600
Query: 601 TQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDE 660
TQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDE
Sbjct: 601 TQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDE 660
Query: 661 GHLPMINQDEFRNFSYVSPELQP 683
GHLPMINQDEFRNFSYVSPELQP
Sbjct: 661 GHLPMINQDEFRNFSYVSPELQP 683
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 917 bits (2371), Expect = 0.0
Identities = 451/737 (61%), Positives = 552/737 (74%), Gaps = 64/737 (8%)
Query: 8 FNGYLRVRIGEAVGLQPTRWSLRHSLFKKGHQ-LLDPYLTVSVDQVRVGQTSTKQKTNKP 66
FNG L+++I EAV L+PT WSLRH++ + LLDPY+ ++VD R+GQT+TKQKTN P
Sbjct: 4 FNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSP 63
Query: 67 TYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFEGWVDLEP 126
+++EF +V +G +ELAVFH+ P+GYD FVANCT+QF+ELL+ S FE W+DLEP
Sbjct: 64 AWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQN--GSRHFEDWIDLEP 121
Query: 127 EGKVFVVITLTGSFTEATLQRD-RIFKHFTR--KRQRAMRRRVHQINGHKFMATYLRQPT 183
EG+V+V+I L+GS EA + R+F+ R KRQ A+RRRVHQ+NGHKFMATYLRQPT
Sbjct: 122 EGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPT 181
Query: 184 YCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIAEQRFGIN 243
YCSHCR+FIWGV GKQGYQCQVCTCVVHKRCH LI+T C D ++ QRF +N
Sbjct: 182 YCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPD-QVGSQRFSVN 240
Query: 244 IPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELA 303
+PHKF IHNYKVPTFCDHCGSLLWG++RQGLQCK+CKMNVH RC+ NVAPNCGV+A +A
Sbjct: 241 MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA 300
Query: 304 KTLAGMGLQPGNI-----------------------SPTSKLVSRS-------------- 326
K LA +G+ P I SP+ + S+S
Sbjct: 301 KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE 360
Query: 327 -------TLRRQGKE----SSKEG-------NG-IGVNSSNRLGIDNFEFIRVLGKGSFG 367
+ +G+E SS +G NG + + RLG+D F FI+VLGKGSFG
Sbjct: 361 NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG 420
Query: 368 KVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPD 427
KVMLA +K ++YAVKVLKKDVILQDDDV+CTMTEKRIL+LAR HP+LTQL+CCFQT D
Sbjct: 421 KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD 480
Query: 428 RLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLL 487
RLFFVME+VNGGDLMF IQ+SR+FDE R+RFYAAE+ SALMFLH G+IYRDLKLDN+LL
Sbjct: 481 RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL 540
Query: 488 DHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEM 547
D EGHCKLADFGMCKEGI NGVTT TFCGTPDYIAPEILQE+ YGP+VDWWA+GVL+YEM
Sbjct: 541 DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM 600
Query: 548 LCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSL-TQGGEH 606
+ G PFEA+NEDDLFE+IL+D+V+YP WL ++A ILK+FMTKNP RLG + +Q GE
Sbjct: 601 MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED 660
Query: 607 AILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMI 666
AI +HPFFKEIDW L ++I+PPF+PRIK++ DV+NFD DF +EEPVLT +DE + I
Sbjct: 661 AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI 720
Query: 667 NQDEFRNFSYVSPELQP 683
NQ+EF+ FSY +L P
Sbjct: 721 NQEEFKGFSYFGEDLMP 737
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 556 bits (1434), Expect = e-158
Identities = 282/635 (44%), Positives = 400/635 (62%), Gaps = 22/635 (3%)
Query: 60 KQKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFE 119
K+ T P + F A++ +G +++ + ++ + + G + E
Sbjct: 47 KKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKA---E 103
Query: 120 GWVDLEPEGKVFVVIT--LTGSFTEATLQRDRIFKHFTRKRQRAMRR-RVHQINGHKFMA 176
W+DL+P+ KV + + L + +++ + K T R+ A+++ ++H I H+F+A
Sbjct: 104 FWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIA 163
Query: 177 TYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIA 236
T+ QPT+CS C++F+WG+ KQGY+C+ C +HK+C I+ CT N D+
Sbjct: 164 TFFGQPTFCSVCKDFVWGL-NKQGYKCRQCNAAIHKKCIDKIIGRCT-GTAANSRDTIFQ 221
Query: 237 EQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCG 296
++RF I++PH+F +HNY PTFCDHCGSLLWG+++QGL+C+ C MNVH +C+ VA CG
Sbjct: 222 KERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCG 281
Query: 297 VNAVELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNS---------S 347
+N LA+ L + + S ++ + K++ G + NS S
Sbjct: 282 INQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGS 341
Query: 348 NRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRIL 407
++ I+NF F +VLGKGSFGKV+L +K G+ +A+K LKKDV+L DDDVECTM EKR+L
Sbjct: 342 SKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVL 401
Query: 408 SLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 467
+LA +PFLT L C FQT D LFFVMEF+NGGDLM+HIQ RF+ RA FYAAEI+ L
Sbjct: 402 TLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGL 461
Query: 468 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQ 527
FLH KGIIYRDLKLDNVLLD +GH K+ADFGMCKE I +TFCGTPDYIAPEILQ
Sbjct: 462 QFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQ 521
Query: 528 EMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKS 587
+ Y +VDWW+ GVLLYEML G +PF ++ED+LFE+I D YP W+ +++ IL+
Sbjct: 522 GLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEK 581
Query: 588 FMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPD 647
+ PT RLG I HPFFK I+W L R++EPPFRP++KS D SNFD +
Sbjct: 582 LFEREPTKRLGVTGN-----IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQE 636
Query: 648 FIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPELQ 682
F+ E+ L+ D+ + ++Q F FS+V+P+ +
Sbjct: 637 FLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFE 671
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 556 bits (1434), Expect = e-158
Identities = 282/635 (44%), Positives = 400/635 (62%), Gaps = 22/635 (3%)
Query: 60 KQKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFE 119
K+ T P + F A++ +G +++ + ++ + + G + E
Sbjct: 47 KKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKA---E 103
Query: 120 GWVDLEPEGKVFVVIT--LTGSFTEATLQRDRIFKHFTRKRQRAMRR-RVHQINGHKFMA 176
W+DL+P+ KV + + L + +++ + K T R+ A+++ ++H I H+F+A
Sbjct: 104 FWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIA 163
Query: 177 TYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIA 236
T+ QPT+CS C++F+WG+ KQGY+C+ C +HK+C I+ CT N D+
Sbjct: 164 TFFGQPTFCSVCKDFVWGL-NKQGYKCRQCNAAIHKKCIDKIIGRCT-GTAANSRDTIFQ 221
Query: 237 EQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCG 296
++RF I++PH+F +HNY PTFCDHCGSLLWG+++QGL+C+ C MNVH +C+ VA CG
Sbjct: 222 KERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCG 281
Query: 297 VNAVELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNS---------S 347
+N LA+ L + + S ++ + K++ G + NS S
Sbjct: 282 INQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGS 341
Query: 348 NRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRIL 407
++ I+NF F +VLGKGSFGKV+L +K G+ +A+K LKKDV+L DDDVECTM EKR+L
Sbjct: 342 SKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVL 401
Query: 408 SLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 467
+LA +PFLT L C FQT D LFFVMEF+NGGDLM+HIQ RF+ RA FYAAEI+ L
Sbjct: 402 TLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGL 461
Query: 468 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQ 527
FLH KGIIYRDLKLDNVLLD +GH K+ADFGMCKE I +TFCGTPDYIAPEILQ
Sbjct: 462 QFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQ 521
Query: 528 EMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKS 587
+ Y +VDWW+ GVLLYEML G +PF ++ED+LFE+I D YP W+ +++ IL+
Sbjct: 522 GLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEK 581
Query: 588 FMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPD 647
+ PT RLG I HPFFK I+W L R++EPPFRP++KS D SNFD +
Sbjct: 582 LFEREPTKRLGVTGN-----IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQE 636
Query: 648 FIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPELQ 682
F+ E+ L+ D+ + ++Q F FS+V+P+ +
Sbjct: 637 FLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFE 671
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 541 bits (1394), Expect = e-154
Identities = 285/694 (41%), Positives = 413/694 (59%), Gaps = 64/694 (9%)
Query: 39 QLLDPYLTVSVDQVRVGQTST----KQKTNKPTYNEEFCANVTDGGHLELAVFHETPLGY 94
+ ++PY V V + + K+ T P ++ F A++ G +++ V +
Sbjct: 23 EAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNV--- 79
Query: 95 DHFVANCTLQFQELL-RTTGASDTFEGWVDLEPEGKV------FVVITLTGSFTEATLQR 147
++ T++ L R + E W++L+P+G++ F+ ++ T E +
Sbjct: 80 -DLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETEG 138
Query: 148 DRIFKHFTRKRQRAMRRRVHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCT 207
F ++R + +VH + H+F AT+ QPT+CS C EF+WG+ KQGYQC+ C
Sbjct: 139 ---FFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGL-NKQGYQCRQCN 194
Query: 208 CVVHKRCHHLIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLW 267
+HK+C ++ CT + IN ++ ++RF I++PH+F ++NYK PTFC+HCG+LLW
Sbjct: 195 AAIHKKCIDKVIAKCT-GSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLW 253
Query: 268 GIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKTLAGM-GLQPGNISPTSKLVSRS 326
G+ RQGL+C C MNVH RCQ VA CG+N +A+ LA + Q ++ + R
Sbjct: 254 GLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTEQIFRE 313
Query: 327 ---------TLRRQGKE------SSKEGNGIGVNS-----------------------SN 348
+++ + + +E GI S
Sbjct: 314 GPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQI 373
Query: 349 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 408
+L I++F ++LGKGSFGKV LA K+T +A+K LKKDV+L DDDVECTM EKR+LS
Sbjct: 374 KLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 433
Query: 409 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALM 468
LA HPFLT +FC FQT + LFFVME++NGGDLM+HIQ +FD +RA FYAAEII L
Sbjct: 434 LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 493
Query: 469 FLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE 528
FLH KGI+YRDLKLDN+LLD +GH K+ADFGMCKE + T TFCGTPDYIAPEIL
Sbjct: 494 FLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLG 553
Query: 529 MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSF 588
Y +VDWW+ GVLLYEML G +PF ++E++LF +I D YP WL ++A +L
Sbjct: 554 QKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKL 613
Query: 589 MTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDF 648
+ P RLG +G I +HP F+EI+W +L ++I+PPFRP++KS D SNFD +F
Sbjct: 614 FVREPEKRLG--VRGD---IRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEF 668
Query: 649 IKEEPVLTPIDEGHLPMINQDEFRNFSYVSPELQ 682
+ E+P L+ D + ++Q+ FRNFS+++P ++
Sbjct: 669 LNEKPRLSFADRALINSMDQNMFRNFSFMNPGME 702
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 410 bits (1055), Expect = e-114
Identities = 197/333 (59%), Positives = 247/333 (74%), Gaps = 1/333 (0%)
Query: 348 NRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRIL 407
+R+ + +F F+ VLGKGSFGKVML+ K T +LYAVK+LKKDV++QDDDVECTM EKR+L
Sbjct: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVL 394
Query: 408 SLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 467
+L PFLTQL CFQT DRL+FVME+VNGGDLM+HIQ+ RF E A FYAAEI L
Sbjct: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454
Query: 468 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQ 527
FL KGIIYRDLKLDNV+LD EGH K+ADFGMCKE I +GVTT TFCGTPDYIAPEI+
Sbjct: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514
Query: 528 EMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKS 587
YG +VDWWA GVLLYEML G APFE E+ED+LF++I+ V YP + ++A I K
Sbjct: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574
Query: 588 FMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPD 647
MTK+P RLG + GE I H FF+ IDW +L ++I+PP++P+ + + D SNFD +
Sbjct: 575 LMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKE 633
Query: 648 FIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE 680
F ++ LTP D+ + ++Q+EF FSY +PE
Sbjct: 634 FTRQPVELTPTDKLFIMNLDQNEFAGFSYTNPE 666
Score = 158 bits (400), Expect = 1e-38
Identities = 72/145 (49%), Positives = 94/145 (64%), Gaps = 10/145 (6%)
Query: 158 RQRAMRRR-VHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHH 216
R+ A+R++ VH++ HKF A + +QPT+CSHC +FIWG FGKQG+QCQVC VVHKRCH
Sbjct: 22 RKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWG-FGKQGFQCQVCCFVVHKRCHE 80
Query: 217 LIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQC 276
+ +C + D ++ HKF IH Y PTFCDHCGSLL+G++ QG++C
Sbjct: 81 FVTFSCPGADKGPASDDPRSK--------HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKC 132
Query: 277 KICKMNVHIRCQANVAPNCGVNAVE 301
C MNVH RC NV CG + E
Sbjct: 133 DTCMMNVHKRCVMNVPSLCGTDHTE 157
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 404 bits (1039), Expect = e-112
Identities = 196/336 (58%), Positives = 250/336 (74%), Gaps = 2/336 (0%)
Query: 345 NSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEK 404
N+ +R+ + +F F+ VLGKGSFGKVMLA K T +LYA+K+LKKDV++QDDDVECTM EK
Sbjct: 329 NNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEK 388
Query: 405 RILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEII 464
R+L+L PFLTQL CFQT DRL+FVME+VNGGDLM+HIQ+ +F E +A FYAAEI
Sbjct: 389 RVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEIS 448
Query: 465 SALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPE 524
L FLH +GIIYRDLKLDNV+LD EGH K+ADFGMCKE + +GVTT TFCGTPDYIAPE
Sbjct: 449 IGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPE 508
Query: 525 ILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGI 584
I+ YG +VDWWA GVLLYEML G PF+ E+ED+LF++I+ V YP L ++A I
Sbjct: 509 IIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSI 568
Query: 585 LKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNF 644
K MTK+P RLG + GE + H FF+ IDW +L +R+I+PPF+P++ + NF
Sbjct: 569 CKGLMTKHPAKRLGCGPE-GERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENF 626
Query: 645 DPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE 680
D F + +PVLTP D+ + I+Q +F FSYV+P+
Sbjct: 627 DKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQ 662
Score = 157 bits (398), Expect = 2e-38
Identities = 71/145 (48%), Positives = 96/145 (66%), Gaps = 10/145 (6%)
Query: 158 RQRAMRRR-VHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHH 216
R+ A+R++ VH++ HKF+A + +QPT+CSHC +FIWG FGKQG+QCQVC VVHKRCH
Sbjct: 22 RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWG-FGKQGFQCQVCCFVVHKRCHE 80
Query: 217 LIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQC 276
+ +C + D ++ HKF IH Y PTFCDHCGSLL+G++ QG++C
Sbjct: 81 FVTFSCPGADKGPDTDDPRSK--------HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKC 132
Query: 277 KICKMNVHIRCQANVAPNCGVNAVE 301
C MNVH +C NV CG++ E
Sbjct: 133 DTCDMNVHKQCVINVPSLCGMDHTE 157
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 402 bits (1032), Expect = e-112
Identities = 198/333 (59%), Positives = 244/333 (73%), Gaps = 2/333 (0%)
Query: 348 NRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRIL 407
+R+ + +F F+ VLGKGSFGKVML+ K T +LYAVK+LKKDV++QDDDVECTM EKR+L
Sbjct: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVL 394
Query: 408 SLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 467
+L PFLTQL CFQT DRL+FVME+VNGGDLM+HIQ+ RF E A FYAAEI L
Sbjct: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454
Query: 468 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQ 527
FL KGIIYRDLKLDNV+LD EGH K+ADFGMCKE I +GVTT TFCGTPDYIAPEI+
Sbjct: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514
Query: 528 EMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKS 587
YG +VDWWA GVLLYEML G APFE E+ED+LF++I+ V YP + ++A I K
Sbjct: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574
Query: 588 FMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPD 647
MTK+P RLG + GE I H FF+ IDW +L ++I+PP++P+ R + NFD
Sbjct: 575 LMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRF 632
Query: 648 FIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE 680
F + PVLTP D+ + I+Q EF FS+V+ E
Sbjct: 633 FTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSE 665
Score = 158 bits (400), Expect = 1e-38
Identities = 72/145 (49%), Positives = 94/145 (64%), Gaps = 10/145 (6%)
Query: 158 RQRAMRRR-VHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHH 216
R+ A+R++ VH++ HKF A + +QPT+CSHC +FIWG FGKQG+QCQVC VVHKRCH
Sbjct: 22 RKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWG-FGKQGFQCQVCCFVVHKRCHE 80
Query: 217 LIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQC 276
+ +C + D ++ HKF IH Y PTFCDHCGSLL+G++ QG++C
Sbjct: 81 FVTFSCPGADKGPASDDPRSK--------HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKC 132
Query: 277 KICKMNVHIRCQANVAPNCGVNAVE 301
C MNVH RC NV CG + E
Sbjct: 133 DTCMMNVHKRCVMNVPSLCGTDHTE 157
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 392 bits (1006), Expect = e-109
Identities = 197/449 (43%), Positives = 272/449 (60%), Gaps = 13/449 (2%)
Query: 246 HKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKT 305
H F + C C +WG+ RQG +C CK+ VH +C V CG +++
Sbjct: 141 HTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPQEPV 200
Query: 306 L----AGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRVL 361
+ + M S +L + G+E +S+ LG+ +F+ +RV+
Sbjct: 201 MPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVI 260
Query: 362 GKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFC 421
G+GS+ KV+L R+K+T +YA+KV+KK+++ D+D++ TEK + A NHPFL L
Sbjct: 261 GRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHS 320
Query: 422 CFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLK 481
CFQT RLFFV+E+VNGGDLMFH+Q+ R+ E ARFY+AEI AL +LH++GIIYRDLK
Sbjct: 321 CFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLK 380
Query: 482 LDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMG 541
LDNVLLD EGH KL D+GMCKEG+ G TT+TFCGTP+YIAPEIL+ YG +VDWWA+G
Sbjct: 381 LDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALG 440
Query: 542 VLLYEMLCGHAPF---------EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKN 592
VL++EM+ G +PF + ED LF+ IL ++ P L A +LKSF+ K+
Sbjct: 441 VLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKD 500
Query: 593 PTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEE 652
P RLG Q G I HPFF+ +DW + +Q+ PPF+P I + NFD F E
Sbjct: 501 PKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEP 560
Query: 653 PVLTPIDEGHLPMINQDEFRNFSYVSPEL 681
LTP D+ + I+Q EF F Y++P L
Sbjct: 561 VQLTPDDDDIVRKIDQSEFEGFEYINPLL 589
Score = 60.1 bits (144), Expect = 7e-09
Identities = 24/59 (40%), Positives = 37/59 (62%), Gaps = 1/59 (1%)
Query: 164 RRVHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTAC 222
R+++ NGH F A + +C+ C + IWG+ G+QGY+C C +VHK+CH L+ C
Sbjct: 133 RKLYCANGHTFQAKRFNRRAHCAICTDRIWGL-GRQGYKCINCKLLVHKKCHKLVTIEC 190
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 384 bits (986), Expect = e-106
Identities = 194/340 (57%), Positives = 238/340 (70%), Gaps = 7/340 (2%)
Query: 346 SSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKR 405
S RL I +F F+ VLGKGSFGKVMLA + + +LYA+K+LKKDVI+QDDDV+CT+ EKR
Sbjct: 342 SPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKR 401
Query: 406 ILSLARNHP-----FLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYA 460
+L+L P FLTQL FQTPDRL+FVME+V GGDLM+HIQ+ +F E A FYA
Sbjct: 402 VLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYA 461
Query: 461 AEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDY 520
AEI L FLH++GIIYRDLKLDNV+LD EGH K+ DFGMCKE + G TT TFCGTPDY
Sbjct: 462 AEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDY 521
Query: 521 IAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHED 580
IAPEI+ YG +VDWW+ GVLLYEML G PF+ E+E++LF+AI+ V YP L +
Sbjct: 522 IAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSRE 581
Query: 581 ATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSRED 640
A I K F+TK+P RLGS GE I H FF+ IDW +L +I PPFRPR R
Sbjct: 582 AVAICKGFLTKHPGKRLGS-GPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSG 640
Query: 641 VSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE 680
NFD F + P LTP D L I+Q +F+ F+YV+P+
Sbjct: 641 -ENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPD 679
Score = 154 bits (390), Expect = 2e-37
Identities = 69/145 (47%), Positives = 95/145 (65%), Gaps = 10/145 (6%)
Query: 158 RQRAMRRRV-HQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHH 216
R+ A+R++V H++ HKF A + +QPT+CSHC +FIWG+ GKQG QCQVC+ VVH+RCH
Sbjct: 21 RKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGI-GKQGLQCQVCSFVVHRRCHE 79
Query: 217 LIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQC 276
+ C + D + HKF +H+Y PTFCDHCGSLL+G++ QG++C
Sbjct: 80 FVTFECPGAGKGPQTDDPRNK--------HKFRLHSYSSPTFCDHCGSLLYGLVHQGMKC 131
Query: 277 KICKMNVHIRCQANVAPNCGVNAVE 301
C+MNVH RC +V CGV+ E
Sbjct: 132 SCCEMNVHRRCVRSVPSLCGVDHTE 156
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 380 bits (976), Expect = e-105
Identities = 197/455 (43%), Positives = 270/455 (59%), Gaps = 19/455 (4%)
Query: 246 HKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKT 305
H F + +C C +WG+ RQG +C CK+ VH RC V C + + +
Sbjct: 131 HLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPS 190
Query: 306 LAGM-------GLQPGNISPTSKLVSRSTLRRQGKESSKEGNGI-----GVNSSNRLGID 353
P + +S S K+ S++ + G+ S LG+
Sbjct: 191 QEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQ 250
Query: 354 NFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNH 413
+F+ IRV+G+GS+ KV+L R+K+ +YA+KV+KK+++ D+D++ TEK + A ++
Sbjct: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
Query: 414 PFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDK 473
PFL L CFQT RLF V+E+VNGGDLMFH+Q+ R+ E ARFYAAEI AL FLH++
Sbjct: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
Query: 474 GIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGP 533
GIIYRDLKLDNVLLD +GH KL D+GMCKEG+ G TT+TFCGTP+YIAPEIL+ YG
Sbjct: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
Query: 534 AVDWWAMGVLLYEMLCGHAPF-------EAENEDDLFEAILNDEVVYPTWLHEDATGILK 586
+VDWWA+GVL++EM+ G +PF + ED LF+ IL + P +L A+ +LK
Sbjct: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
Query: 587 SFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP 646
F+ K+P RLG Q G I H FF+ IDW L +Q PPF+P+I + NFD
Sbjct: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
Query: 647 DFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPEL 681
F E LTP DE + I+Q EF F Y++P L
Sbjct: 551 QFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLL 585
Score = 63.5 bits (153), Expect = 6e-10
Identities = 28/68 (41%), Positives = 42/68 (61%), Gaps = 3/68 (4%)
Query: 164 RRVHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACT 223
R++++ NGH F A + YC C E IWG+ +QGY+C C +VHKRCH L+ T
Sbjct: 123 RKLYRANGHLFQAKRFNRRAYCGQCSERIWGL-ARQGYRCINCKLLVHKRCHGLV--PLT 179
Query: 224 CQNNINKV 231
C+ +++ V
Sbjct: 180 CRKHMDSV 187
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 356 bits (913), Expect = 4e-98
Identities = 174/346 (50%), Positives = 232/346 (67%), Gaps = 7/346 (2%)
Query: 343 GVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMT 402
G+ S LG+ +F+ IRV+G+GS+ KV+L R+K+ +YA+KV+KK+++ D+D++ T
Sbjct: 57 GIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQT 116
Query: 403 EKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAE 462
EK + A ++PFL L CFQT RLF V+E+VNGGDLMFH+Q+ R+ E ARFYAAE
Sbjct: 117 EKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAE 176
Query: 463 IISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIA 522
I AL FLH++GIIYRDLKLDNVLLD +GH KL D+GMCKEG+ G TT+TFCGTP+YIA
Sbjct: 177 ICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIA 236
Query: 523 PEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF-------EAENEDDLFEAILNDEVVYPT 575
PEIL+ YG +VDWWA+GVL++EM+ G +PF + ED LF+ IL + P
Sbjct: 237 PEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPR 296
Query: 576 WLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRI 635
+L A+ +LK F+ K+P RLG Q G I H FF+ IDW L +Q PPF+P+I
Sbjct: 297 FLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQI 356
Query: 636 KSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPEL 681
+ NFD F E LTP DE + I+Q EF F Y++P L
Sbjct: 357 TDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLL 402
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 356 bits (913), Expect = 4e-98
Identities = 174/346 (50%), Positives = 232/346 (67%), Gaps = 7/346 (2%)
Query: 343 GVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMT 402
G+ S LG+ +F+ IRV+G+GS+ KV+L R+K+ +YA+KV+KK+++ D+D++ T
Sbjct: 57 GIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQT 116
Query: 403 EKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAE 462
EK + A ++PFL L CFQT RLF V+E+VNGGDLMFH+Q+ R+ E ARFYAAE
Sbjct: 117 EKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAE 176
Query: 463 IISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIA 522
I AL FLH++GIIYRDLKLDNVLLD +GH KL D+GMCKEG+ G TT+TFCGTP+YIA
Sbjct: 177 ICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIA 236
Query: 523 PEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF-------EAENEDDLFEAILNDEVVYPT 575
PEIL+ YG +VDWWA+GVL++EM+ G +PF + ED LF+ IL + P
Sbjct: 237 PEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPR 296
Query: 576 WLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRI 635
+L A+ +LK F+ K+P RLG Q G I H FF+ IDW L +Q PPF+P+I
Sbjct: 297 FLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQI 356
Query: 636 KSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPEL 681
+ NFD F E LTP DE + I+Q EF F Y++P L
Sbjct: 357 TDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLL 402
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 332 bits (852), Expect = 5e-91
Identities = 169/364 (46%), Positives = 236/364 (64%), Gaps = 11/364 (3%)
Query: 324 SRSTLRRQGKESSKEGNGIGVNSSNR------LGIDNFEFIRVLGKGSFGKVMLARVKET 377
S+S + +S E +GI R + +F VLG+G FGKV+LA K T
Sbjct: 620 SQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNT 679
Query: 378 GDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN--HPFLTQLFCCFQTPDRLFFVMEF 435
+++A+K LKK I+ D+V+ M EKRI + HPFL LF CFQT + + FVME+
Sbjct: 680 NEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEY 739
Query: 436 VNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKL 495
GGDLM HI F E RA FYAA ++ L +LH+ I+YRDLKLDN+LLD EG K+
Sbjct: 740 AAGGDLMMHIHTDV-FSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKI 798
Query: 496 ADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFE 555
ADFG+CKEG+ G T+TFCGTP+++APE+L E Y AVDWW +GVL+YEML G +PF
Sbjct: 799 ADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFP 858
Query: 556 AENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFK 615
++E+++F++I+NDEV YP +L +A I++ + +NP RLG+ + E + +HPFF+
Sbjct: 859 GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAED-VKKHPFFR 917
Query: 616 EIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGH-LPMINQDEFRNF 674
IDW+ L ++++PPF P I+ REDVSNFD +F E P+LTP E L Q+ FR+F
Sbjct: 918 LIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDF 977
Query: 675 SYVS 678
Y++
Sbjct: 978 DYIA 981
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 328 bits (840), Expect = 1e-89
Identities = 173/372 (46%), Positives = 243/372 (65%), Gaps = 9/372 (2%)
Query: 313 PGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNR---LGIDNFEFIRVLGKGSFGKV 369
P + S S + ST E+ +E G + S R L +++F+F+ VLG+G FGKV
Sbjct: 577 PSSPSSLSSPIQESTAPELPSET-QETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKV 635
Query: 370 MLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN--HPFLTQLFCCFQTPD 427
+L+ + +G+L+A+K LKK I+ D+VE M EKRIL+ + HPFL LF CFQTP+
Sbjct: 636 LLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPE 695
Query: 428 RLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLL 487
+ FVME+ GGDLM HI S F E RA FY+A ++ L FLH+ I+YRDLKLDN+LL
Sbjct: 696 HVCFVMEYSAGGDLMLHIH-SDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLL 754
Query: 488 DHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEM 547
D EG+ K+ADFG+CKEG+ G T+TFCGTP+++APE+L + Y AVDWW +GVLLYEM
Sbjct: 755 DTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEM 814
Query: 548 LCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHA 607
L G +PF ++E+++F++I+NDEV YP +L +A GI++ + +NP RLGS + E
Sbjct: 815 LVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAED- 873
Query: 608 ILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT-PIDEGHLPMI 666
+ + PFF+ + W L R++ PPF P + R DVSNFD +F E P L+ P D L
Sbjct: 874 VKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAA 933
Query: 667 NQDEFRNFSYVS 678
Q F +F +V+
Sbjct: 934 EQAAFLDFDFVA 945
Score = 36.2 bits (82), Expect = 0.10
Identities = 34/135 (25%), Positives = 58/135 (42%), Gaps = 8/135 (5%)
Query: 30 RHSLFKKGHQLLDPYLTVSVDQVRVGQTSTKQKTNKPTYNEEFCANVTDGGHLELAVFHE 89
R SL + + + +D VGQTS K +++ F + LELAVF
Sbjct: 384 RSSLKAEAENTSEVSTVLKLDNTVVGQTSWKP-CGPNAWDQSFTLELERARELELAVFWR 442
Query: 90 TPLGYDHFVANCTLQFQELLRTTGASDTFEGWVDLEPEGKVFVVITLTGSFTEATLQRDR 149
G C L+F +L ++ E +D+EP+G + +T E + R
Sbjct: 443 DQRGL------CALKFLKLEDFLD-NERHEVQLDMEPQGCLVAEVTFRNPVIERIPRLRR 495
Query: 150 IFKHFTRKRQRAMRR 164
K F++++ +A +R
Sbjct: 496 QKKIFSKQQGKAFQR 510
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 328 bits (840), Expect = 1e-89
Identities = 173/372 (46%), Positives = 243/372 (65%), Gaps = 9/372 (2%)
Query: 313 PGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNR---LGIDNFEFIRVLGKGSFGKV 369
P + S S + ST E+ +E G + S R L +++F+F+ VLG+G FGKV
Sbjct: 571 PSSPSSLSSPIQESTAPELPSET-QETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKV 629
Query: 370 MLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN--HPFLTQLFCCFQTPD 427
+L+ + +G+L+A+K LKK I+ D+VE M EKRIL+ + HPFL LF CFQTP+
Sbjct: 630 LLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPE 689
Query: 428 RLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLL 487
+ FVME+ GGDLM HI S F E RA FY+A ++ L FLH+ I+YRDLKLDN+LL
Sbjct: 690 HVCFVMEYSAGGDLMLHIH-SDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLL 748
Query: 488 DHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEM 547
D EG+ K+ADFG+CKEG+ G T+TFCGTP+++APE+L + Y AVDWW +GVLLYEM
Sbjct: 749 DTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEM 808
Query: 548 LCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHA 607
L G +PF ++E+++F++I+NDEV YP +L +A GI++ + +NP RLGS + E
Sbjct: 809 LVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAED- 867
Query: 608 ILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT-PIDEGHLPMI 666
+ + PFF+ + W L R++ PPF P + R DVSNFD +F E P L+ P D L
Sbjct: 868 VKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAA 927
Query: 667 NQDEFRNFSYVS 678
Q F +F +V+
Sbjct: 928 EQAAFLDFDFVA 939
Score = 36.2 bits (82), Expect = 0.10
Identities = 34/135 (25%), Positives = 58/135 (42%), Gaps = 8/135 (5%)
Query: 30 RHSLFKKGHQLLDPYLTVSVDQVRVGQTSTKQKTNKPTYNEEFCANVTDGGHLELAVFHE 89
R SL + + + +D VGQTS K +++ F + LELAVF
Sbjct: 378 RSSLKAEAENTSEVSTVLKLDNTVVGQTSWKP-CGPNAWDQSFTLELERARELELAVFWR 436
Query: 90 TPLGYDHFVANCTLQFQELLRTTGASDTFEGWVDLEPEGKVFVVITLTGSFTEATLQRDR 149
G C L+F +L ++ E +D+EP+G + +T E + R
Sbjct: 437 DQRGL------CALKFLKLEDFLD-NERHEVQLDMEPQGCLVAEVTFRNPVIERIPRLRR 489
Query: 150 IFKHFTRKRQRAMRR 164
K F++++ +A +R
Sbjct: 490 QKKIFSKQQGKAFQR 504
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 326 bits (836), Expect = 4e-89
Identities = 153/332 (46%), Positives = 225/332 (67%), Gaps = 6/332 (1%)
Query: 349 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 408
++ +++F+++++LGKG+FGKV+L R K TG YA+K+L+K+VI+ D+V T+TE R+L
Sbjct: 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 205
Query: 409 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALM 468
R HPFLT L FQT DRL FVME+ NGG+L FH+ + R F E RARFY AEI+SAL
Sbjct: 206 NTR-HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALE 264
Query: 469 FLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE 528
+LH + ++YRD+KL+N++LD +GH K+ DFG+CKEGI +G T TFCGTP+Y+APE+L++
Sbjct: 265 YLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED 324
Query: 529 MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSF 588
YG AVDWW +GV++YEM+CG PF ++ + LFE IL +E+ +P L +A +L
Sbjct: 325 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGL 384
Query: 589 MTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDF 648
+ K+P RLG + ++ H FF I+W + +++ PPF+P++ S D FD +F
Sbjct: 385 LKKDPKQRLGGGPSDAKE-VMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEF 443
Query: 649 IKEEPVLTPIDE----GHLPMINQDEFRNFSY 676
+ +TP D G L + + F FSY
Sbjct: 444 TAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 325 bits (833), Expect = 9e-89
Identities = 161/368 (43%), Positives = 233/368 (63%), Gaps = 18/368 (4%)
Query: 315 NISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARV 374
N SPTS++ +E R +++F+++++LGKG+FGKV+L R
Sbjct: 118 NCSPTSQI----------DNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVRE 167
Query: 375 KETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVME 434
K +G YA+K+LKK+VI+ D+V T+TE R+L R HPFLT L FQT DRL FVME
Sbjct: 168 KASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTSLKYSFQTKDRLCFVME 226
Query: 435 FVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCK 494
+VNGG+L FH+ + R F E R RFY AEI+SAL +LH I+YRDLKL+N++LD +GH K
Sbjct: 227 YVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIK 286
Query: 495 LADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF 554
+ DFG+CKEGI + T TFCGTP+Y+APE+L++ YG AVDWW +GV++YEM+CG PF
Sbjct: 287 ITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
Query: 555 EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFF 614
++ + LFE IL +++ +P L DA +L + K+P RLG + I+RH FF
Sbjct: 347 YNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKE-IMRHSFF 405
Query: 615 KEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTP---IDEGHLPMINQD-- 669
++W + +++ PPF+P++ S D FD +F + +TP DE + ++ +
Sbjct: 406 SGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERR 465
Query: 670 -EFRNFSY 676
F FSY
Sbjct: 466 PHFPQFSY 473
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 324 bits (831), Expect = 1e-88
Identities = 152/314 (48%), Positives = 222/314 (70%), Gaps = 3/314 (0%)
Query: 348 NRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRIL 407
+R+ ++ FE++++LGKG+FGKV+L + K TG YA+K+LKK+VI+ D+V T+TE R+L
Sbjct: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202
Query: 408 SLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 467
+R HPFLT L FQT DRL FVME+ NGG+L FH+ + R F E RARFY AEI+SAL
Sbjct: 203 QNSR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 468 MFLH-DKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL 526
+LH +K ++YRDLKL+N++LD +GH K+ DFG+CKEGI +G T TFCGTP+Y+APE+L
Sbjct: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321
Query: 527 QEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILK 586
++ YG AVDWW +GV++YEM+CG PF ++ + LFE IL +E+ +P L +A +L
Sbjct: 322 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 381
Query: 587 SFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP 646
+ K+P RLG ++ + I++H FF I W + +++ PPF+P++ S D FD
Sbjct: 382 GLLKKDPKQRLGGGSEDAKE-IMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
Query: 647 DFIKEEPVLTPIDE 660
+F + +TP D+
Sbjct: 441 EFTAQMITITPPDQ 454
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 324 bits (831), Expect = 1e-88
Identities = 152/314 (48%), Positives = 222/314 (70%), Gaps = 3/314 (0%)
Query: 348 NRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRIL 407
+R+ ++ FE++++LGKG+FGKV+L + K TG YA+K+LKK+VI+ D+V T+TE R+L
Sbjct: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202
Query: 408 SLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 467
+R HPFLT L FQT DRL FVME+ NGG+L FH+ + R F E RARFY AEI+SAL
Sbjct: 203 QNSR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 468 MFLH-DKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL 526
+LH +K ++YRDLKL+N++LD +GH K+ DFG+CKEGI +G T TFCGTP+Y+APE+L
Sbjct: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321
Query: 527 QEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILK 586
++ YG AVDWW +GV++YEM+CG PF ++ + LFE IL +E+ +P L +A +L
Sbjct: 322 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 381
Query: 587 SFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP 646
+ K+P RLG ++ + I++H FF I W + +++ PPF+P++ S D FD
Sbjct: 382 GLLKKDPKQRLGGGSEDAKE-IMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
Query: 647 DFIKEEPVLTPIDE 660
+F + +TP D+
Sbjct: 441 EFTAQMITITPPDQ 454
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 324 bits (831), Expect = 1e-88
Identities = 152/314 (48%), Positives = 222/314 (70%), Gaps = 3/314 (0%)
Query: 348 NRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRIL 407
+R+ ++ FE++++LGKG+FGKV+L + K TG YA+K+LKK+VI+ D+V T+TE R+L
Sbjct: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202
Query: 408 SLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 467
+R HPFLT L FQT DRL FVME+ NGG+L FH+ + R F E RARFY AEI+SAL
Sbjct: 203 QNSR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 468 MFLH-DKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL 526
+LH +K ++YRDLKL+N++LD +GH K+ DFG+CKEGI +G T TFCGTP+Y+APE+L
Sbjct: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321
Query: 527 QEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILK 586
++ YG AVDWW +GV++YEM+CG PF ++ + LFE IL +E+ +P L +A +L
Sbjct: 322 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 381
Query: 587 SFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP 646
+ K+P RLG ++ + I++H FF I W + +++ PPF+P++ S D FD
Sbjct: 382 GLLKKDPKQRLGGGSEDAKE-IMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
Query: 647 DFIKEEPVLTPIDE 660
+F + +TP D+
Sbjct: 441 EFTAQMITITPPDQ 454
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 323 bits (829), Expect = 2e-88
Identities = 155/343 (45%), Positives = 223/343 (65%), Gaps = 12/343 (3%)
Query: 315 NISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARV 374
N SPTS++ +E R +++F+++++LGKG+FGKV+L R
Sbjct: 118 NCSPTSQI----------DNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVRE 167
Query: 375 KETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVME 434
K +G YA+K+LKK+VI+ D+V T+TE R+L R HPFLT L FQT DRL FVME
Sbjct: 168 KASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTSLKYSFQTKDRLCFVME 226
Query: 435 FVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCK 494
+VNGG+L FH+ + R F E R RFY AEI+SAL +LH I+YRDLKL+N++LD +GH K
Sbjct: 227 YVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIK 286
Query: 495 LADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF 554
+ DFG+CKEGI + T TFCGTP+Y+APE+L++ YG AVDWW +GV++YEM+CG PF
Sbjct: 287 ITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
Query: 555 EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFF 614
++ + LFE IL +++ +P L DA +L + K+P RLG + I+RH FF
Sbjct: 347 YNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKE-IMRHSFF 405
Query: 615 KEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTP 657
++W + +++ PPF+P++ S D FD +F + +TP
Sbjct: 406 SGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITP 448
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 289 bits (739), Expect = 7e-78
Identities = 145/318 (45%), Positives = 208/318 (65%), Gaps = 3/318 (0%)
Query: 335 SSKEGN-GIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQ 393
S GN +G +++ +F+F++V+GKG++GKV+LA+ K G YAVKVL+K IL+
Sbjct: 14 SRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILK 73
Query: 394 DDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDE 453
+ M E+ +L HPFL L FQTP++L+FV+++VNGG+L FH+Q+ RRF E
Sbjct: 74 KKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLE 133
Query: 454 ARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTAT 513
RARFYAAE+ SA+ +LH IIYRDLK +N+LLD +GH L DFG+CKEG+ TT+T
Sbjct: 134 PRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTST 193
Query: 514 FCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVY 573
FCGTP+Y+APE+L++ Y AVDWW +G +LYEML G PF +++ ++E IL+ +
Sbjct: 194 FCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQI 253
Query: 574 PTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRP 633
P A +L+S + K+ RLGS E I H FF I+W L H+++ PPF P
Sbjct: 254 PGGRTVAACDLLQSLLHKDQRQRLGSKADFLE--IKNHVFFSPINWDDLYHKRLTPPFNP 311
Query: 634 RIKSREDVSNFDPDFIKE 651
+ D+ +FDP+F +E
Sbjct: 312 NVTGPADLKHFDPEFTQE 329
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 289 bits (739), Expect = 7e-78
Identities = 145/318 (45%), Positives = 208/318 (65%), Gaps = 3/318 (0%)
Query: 335 SSKEGN-GIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQ 393
S GN +G +++ +F+F++V+GKG++GKV+LA+ K G YAVKVL+K IL+
Sbjct: 74 SRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILK 133
Query: 394 DDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDE 453
+ M E+ +L HPFL L FQTP++L+FV+++VNGG+L FH+Q+ RRF E
Sbjct: 134 KKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLE 193
Query: 454 ARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTAT 513
RARFYAAE+ SA+ +LH IIYRDLK +N+LLD +GH L DFG+CKEG+ TT+T
Sbjct: 194 PRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTST 253
Query: 514 FCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVY 573
FCGTP+Y+APE+L++ Y AVDWW +G +LYEML G PF +++ ++E IL+ +
Sbjct: 254 FCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQI 313
Query: 574 PTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRP 633
P A +L+S + K+ RLGS E I H FF I+W L H+++ PPF P
Sbjct: 314 PGGRTVAACDLLQSLLHKDQRQRLGSKADFLE--IKNHVFFSPINWDDLYHKRLTPPFNP 371
Query: 634 RIKSREDVSNFDPDFIKE 651
+ D+ +FDP+F +E
Sbjct: 372 NVTGPADLKHFDPEFTQE 389
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 288 bits (736), Expect = 2e-77
Identities = 149/355 (41%), Positives = 212/355 (59%), Gaps = 8/355 (2%)
Query: 331 QGKESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDV 390
Q S+ + +G + + +F+F++V+GKGSFGKV+LA+ K G YAVKVL+K +
Sbjct: 138 QKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKI 197
Query: 391 ILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRR 450
+L + + M E+ +L HPFL L FQT ++L+FV++FVNGG+L FH+Q+ R
Sbjct: 198 VLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERS 257
Query: 451 FDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVT 510
F E RARFYAAEI SAL +LH I+YRDLK +N+LLD GH L DFG+CKEGI T
Sbjct: 258 FPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDT 317
Query: 511 TATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDE 570
T TFCGTP+Y+APE++++ Y VDWW +G +LYEML G PF + ++++ IL+
Sbjct: 318 TTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKP 377
Query: 571 VVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPP 630
+ + A IL+ + K+ RLG+ E I HPFF+ + WA L ++I PP
Sbjct: 378 LSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLE--IQNHPFFESLSWADLVQKKIPPP 435
Query: 631 FRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMIN------QDEFRNFSYVSP 679
F P + +D+ NFD F +E + ++N D F FSY P
Sbjct: 436 FNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 288 bits (736), Expect = 2e-77
Identities = 149/355 (41%), Positives = 212/355 (59%), Gaps = 8/355 (2%)
Query: 331 QGKESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDV 390
Q S+ + +G + + +F+F++V+GKGSFGKV+LA+ K G YAVKVL+K +
Sbjct: 138 QKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKI 197
Query: 391 ILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRR 450
+L + + M E+ +L HPFL L FQT ++L+FV++FVNGG+L FH+Q+ R
Sbjct: 198 VLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERS 257
Query: 451 FDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVT 510
F E RARFYAAEI SAL +LH I+YRDLK +N+LLD GH L DFG+CKEGI T
Sbjct: 258 FPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDT 317
Query: 511 TATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDE 570
T TFCGTP+Y+APE++++ Y VDWW +G +LYEML G PF + ++++ IL+
Sbjct: 318 TTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKP 377
Query: 571 VVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPP 630
+ + A IL+ + K+ RLG+ E I HPFF+ + WA L ++I PP
Sbjct: 378 LSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLE--IQNHPFFESLSWADLVQKKIPPP 435
Query: 631 FRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMIN------QDEFRNFSYVSP 679
F P + +D+ NFD F +E + ++N D F FSY P
Sbjct: 436 FNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 286 bits (731), Expect = 6e-77
Identities = 150/345 (43%), Positives = 213/345 (61%), Gaps = 10/345 (2%)
Query: 342 IGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTM 401
+G +S+ +F F++V+GKGSFGKV+LAR K YAVKVL+K IL+ + + M
Sbjct: 85 LGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIM 144
Query: 402 TEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAA 461
+E+ +L HPFL L FQT D+L+FV++++NGG+L +H+Q+ R F E RARFYAA
Sbjct: 145 SERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAA 204
Query: 462 EIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYI 521
EI SAL +LH I+YRDLK +N+LLD +GH L DFG+CKE I + TT+TFCGTP+Y+
Sbjct: 205 EIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYL 264
Query: 522 APEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDA 581
APE+L + Y VDWW +G +LYEML G PF + N ++++ ILN + + A
Sbjct: 265 APEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSA 324
Query: 582 TGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDV 641
+L+ + K+ T RLG+ E I H FF I+W L +++I PPF P + D+
Sbjct: 325 RHLLEGLLQKDRTKRLGAKDDFME--IKSHVFFSLINWDDLINKKITPPFNPNVSGPNDL 382
Query: 642 SNFDPDFIKEEPVLTPIDEGHLPMI-------NQDEFRNFSYVSP 679
+FDP+F EEPV I + ++ + F FSY P
Sbjct: 383 RHFDPEF-TEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 426
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 286 bits (731), Expect = 6e-77
Identities = 150/345 (43%), Positives = 213/345 (61%), Gaps = 10/345 (2%)
Query: 342 IGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTM 401
+G +S+ +F F++V+GKGSFGKV+LAR K YAVKVL+K IL+ + + M
Sbjct: 99 LGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIM 158
Query: 402 TEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAA 461
+E+ +L HPFL L FQT D+L+FV++++NGG+L +H+Q+ R F E RARFYAA
Sbjct: 159 SERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAA 218
Query: 462 EIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYI 521
EI SAL +LH I+YRDLK +N+LLD +GH L DFG+CKE I + TT+TFCGTP+Y+
Sbjct: 219 EIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYL 278
Query: 522 APEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDA 581
APE+L + Y VDWW +G +LYEML G PF + N ++++ ILN + + A
Sbjct: 279 APEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSA 338
Query: 582 TGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDV 641
+L+ + K+ T RLG+ E I H FF I+W L +++I PPF P + D+
Sbjct: 339 RHLLEGLLQKDRTKRLGAKDDFME--IKSHVFFSLINWDDLINKKITPPFNPNVSGPNDL 396
Query: 642 SNFDPDFIKEEPVLTPIDEGHLPMI-------NQDEFRNFSYVSP 679
+FDP+F EEPV I + ++ + F FSY P
Sbjct: 397 RHFDPEF-TEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 440
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 286 bits (731), Expect = 6e-77
Identities = 150/345 (43%), Positives = 213/345 (61%), Gaps = 10/345 (2%)
Query: 342 IGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTM 401
+G +S+ +F F++V+GKGSFGKV+LAR K YAVKVL+K IL+ + + M
Sbjct: 113 LGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIM 172
Query: 402 TEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAA 461
+E+ +L HPFL L FQT D+L+FV++++NGG+L +H+Q+ R F E RARFYAA
Sbjct: 173 SERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAA 232
Query: 462 EIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYI 521
EI SAL +LH I+YRDLK +N+LLD +GH L DFG+CKE I + TT+TFCGTP+Y+
Sbjct: 233 EIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYL 292
Query: 522 APEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDA 581
APE+L + Y VDWW +G +LYEML G PF + N ++++ ILN + + A
Sbjct: 293 APEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSA 352
Query: 582 TGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDV 641
+L+ + K+ T RLG+ E I H FF I+W L +++I PPF P + D+
Sbjct: 353 RHLLEGLLQKDRTKRLGAKDDFME--IKSHVFFSLINWDDLINKKITPPFNPNVSGPNDL 410
Query: 642 SNFDPDFIKEEPVLTPIDEGHLPMI-------NQDEFRNFSYVSP 679
+FDP+F EEPV I + ++ + F FSY P
Sbjct: 411 RHFDPEF-TEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 454
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 286 bits (731), Expect = 6e-77
Identities = 150/345 (43%), Positives = 213/345 (61%), Gaps = 10/345 (2%)
Query: 342 IGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTM 401
+G +S+ +F F++V+GKGSFGKV+LAR K YAVKVL+K IL+ + + M
Sbjct: 180 LGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIM 239
Query: 402 TEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAA 461
+E+ +L HPFL L FQT D+L+FV++++NGG+L +H+Q+ R F E RARFYAA
Sbjct: 240 SERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAA 299
Query: 462 EIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYI 521
EI SAL +LH I+YRDLK +N+LLD +GH L DFG+CKE I + TT+TFCGTP+Y+
Sbjct: 300 EIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYL 359
Query: 522 APEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDA 581
APE+L + Y VDWW +G +LYEML G PF + N ++++ ILN + + A
Sbjct: 360 APEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSA 419
Query: 582 TGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDV 641
+L+ + K+ T RLG+ E I H FF I+W L +++I PPF P + D+
Sbjct: 420 RHLLEGLLQKDRTKRLGAKDDFME--IKSHVFFSLINWDDLINKKITPPFNPNVSGPNDL 477
Query: 642 SNFDPDFIKEEPVLTPIDEGHLPMI-------NQDEFRNFSYVSP 679
+FDP+F EEPV I + ++ + F FSY P
Sbjct: 478 RHFDPEF-TEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 521
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,623,228
Number of Sequences: 37866
Number of extensions: 1218172
Number of successful extensions: 6108
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 766
Number of HSP's successfully gapped in prelim test: 126
Number of HSP's that attempted gapping in prelim test: 3417
Number of HSP's gapped (non-prelim): 1224
length of query: 683
length of database: 18,247,518
effective HSP length: 109
effective length of query: 574
effective length of database: 14,120,124
effective search space: 8104951176
effective search space used: 8104951176
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.