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Search of human proteins with 28373122
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
(1026 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 2082 0.0
gi|75709184 contactin 3 [Homo sapiens] 1416 0.0
gi|28373126 contactin 4 isoform c precursor [Homo sapiens] 1408 0.0
gi|7657361 contactin 6 [Homo sapiens] 1305 0.0
gi|28373129 contactin 5 isoform short [Homo sapiens] 1161 0.0
gi|7657359 contactin 5 isoform long [Homo sapiens] 1154 0.0
gi|4827022 contactin 2 precursor [Homo sapiens] 897 0.0
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens] 878 0.0
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens] 874 0.0
gi|28373124 contactin 4 isoform b precursor [Homo sapiens] 563 e-160
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 383 e-106
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 377 e-104
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 377 e-104
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens] 365 e-101
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens] 365 e-101
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 358 1e-98
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens] 357 3e-98
gi|27894376 cell adhesion molecule with homology to L1CAM precur... 356 7e-98
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 352 8e-97
gi|237858675 neurofascin isoform 1 precursor [Homo sapiens] 339 7e-93
gi|222352127 sidekick 2 [Homo sapiens] 310 4e-84
gi|119220552 sidekick 1 [Homo sapiens] 266 6e-71
gi|237858682 neurofascin isoform 6 precursor [Homo sapiens] 234 2e-61
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens] 232 1e-60
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 232 1e-60
gi|157311649 neogenin homolog 1 [Homo sapiens] 228 3e-59
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 209 1e-53
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 209 1e-53
gi|19743806 roundabout 1 isoform b [Homo sapiens] 207 3e-53
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 207 3e-53
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 2082 bits (5395), Expect = 0.0
Identities = 1026/1026 (100%), Positives = 1026/1026 (100%)
Query: 1 MRLPWELLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHI 60
MRLPWELLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHI
Sbjct: 1 MRLPWELLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHI 60
Query: 61 RWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAY 120
RWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAY
Sbjct: 61 RWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAY 120
Query: 121 LDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLY 180
LDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLY
Sbjct: 121 LDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLY 180
Query: 181 IAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKG 240
IAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKG
Sbjct: 181 IAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKG 240
Query: 241 ATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENS 300
ATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENS
Sbjct: 241 ATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENS 300
Query: 301 RGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRD 360
RGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRD
Sbjct: 301 RGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRD 360
Query: 361 RIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVK 420
RIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVK
Sbjct: 361 RIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVK 420
Query: 421 VGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIAT 480
VGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIAT
Sbjct: 421 VGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIAT 480
Query: 481 NHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLI 540
NHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLI
Sbjct: 481 NHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLI 540
Query: 541 DFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPP 600
DFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPP
Sbjct: 541 DFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPP 600
Query: 601 EAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTAT 660
EAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTAT
Sbjct: 601 EAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTAT 660
Query: 661 VVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITW 720
VVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITW
Sbjct: 661 VVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITW 720
Query: 721 ETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVF 780
ETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVF
Sbjct: 721 ETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVF 780
Query: 781 NNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKY 840
NNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKY
Sbjct: 781 NNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKY 840
Query: 841 WRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPP 900
WRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPP
Sbjct: 841 WRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPP 900
Query: 901 PSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVEL 960
PSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVEL
Sbjct: 901 PSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVEL 960
Query: 961 SLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMISL 1020
SLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMISL
Sbjct: 961 SLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMISL 1020
Query: 1021 TARSSL 1026
TARSSL
Sbjct: 1021 TARSSL 1026
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 1416 bits (3665), Expect = 0.0
Identities = 664/1023 (64%), Positives = 839/1023 (82%), Gaps = 4/1023 (0%)
Query: 1 MRLPWELLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHI 60
M PW+ L+L SFI CL + L GP+FI+EPS +FP+ SE+KK+ L+CE +GNP PH
Sbjct: 1 MMFPWKQLILLSFIGCLGGELLLQGPVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHY 60
Query: 61 RWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAY 120
RW+LNG+D+D M+ RY + G+L++ NPN+ D GTYQC ATNS GTIVSREAKLQFAY
Sbjct: 61 RWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAY 120
Query: 121 LDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSY--QDNRRFVSQETGN 178
L+NFKT+ RSTVSVR GQG+VLLCGPPPHSGELSYAWIFNEYPS+ +D+RRFVSQETG+
Sbjct: 121 LENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGH 180
Query: 179 LYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTA 238
LYI+KVE SDVGNYTCVVT+ VTN +VLG PTPL+LR+DGVMGEYEPKIEVQFPET+P A
Sbjct: 181 LYISKVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAA 240
Query: 239 KGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAE 298
KG+TVKLECFALGNP+P I WRR+DG P + K + K +G+LEIPNFQQEDAG YEC+AE
Sbjct: 241 KGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAE 300
Query: 299 NSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLT 358
NSRGKNVARG+LT+YA+P+W+Q I D+ +A+E++++WEC+A+G+PKP+Y+WLKNG L+
Sbjct: 301 NSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVL 360
Query: 359 RDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTL 418
+R QIE G L I+ ++++D+GM+QC+AENKHG+++S+AEL V+A PDFS+ +K++
Sbjct: 361 EERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQ 420
Query: 419 VKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCI 478
V+VG V ++CKP+ASP+ + +WKKG ++E+ERI++ DG L+I NVTK+DAG+YTC+
Sbjct: 421 VQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCM 480
Query: 479 ATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGH 538
A N FG A+ T +LVV +PTR+ + PS+MDV+VGES++LPCQV HD LDI+FTW FNG
Sbjct: 481 AENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGA 540
Query: 539 LIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPG 598
L DF +DG HFE+VGG S+GDLMIRNIQLKH+GKYVCMVQT VD +S+AADLIVRG PG
Sbjct: 541 LADFKKDGSHFEKVGG-SSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGSPG 599
Query: 599 PPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFT 658
PPE V +DEITDTTAQLSW+ G DNHSP+ Y IQARTPFSVGWQ V+TVPE+IDGKT T
Sbjct: 600 PPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHT 659
Query: 659 ATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVI 718
ATVV LNPWVEYEFR VA+N IG GEPS PSEK RTEEA+PEV P+ V+GGGGS+SELVI
Sbjct: 660 ATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNGGGGSRSELVI 719
Query: 719 TWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVG 778
TW+ VPEELQNG GFGYVVAFRP G W+ TV+ S D RYVFRNES+ P+SP+EVKVG
Sbjct: 720 TWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVG 779
Query: 779 VFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWAS-PLEKNRGRIQGYE 837
V+NNKGEGPFSP T V+SAEEEPT P+ + A SLS+++IEV W + P + + G + GYE
Sbjct: 780 VYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYE 839
Query: 838 VKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTR 897
V+YW KEE++ K++ GN+TS ++ LK ++ Y+ AV+AYNSAG GP SATVNVTT+
Sbjct: 840 VRYWNGGGKEESSSKMKVAGNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTK 899
Query: 898 KPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTS 957
K PPSQPPGN++WN++D+K++LNW+QVKA++NESEV GYKV YR + Q++ V+ TNKTS
Sbjct: 900 KTPPSQPPGNVVWNATDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQNNVQVLNTNKTS 959
Query: 958 VELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIM 1017
EL LP EDYIIE+K +DGGDG+SSEQIRIP+I++ ARGS ++ SN +S+ I+
Sbjct: 960 AELVLPIKEDYIIEVKATTDGGDGTSSEQIRIPRITSMDARGSTSAISNVHPMSSYMPIV 1019
Query: 1018 ISL 1020
+ L
Sbjct: 1020 LFL 1022
>gi|28373126 contactin 4 isoform c precursor [Homo sapiens]
Length = 698
Score = 1408 bits (3644), Expect = 0.0
Identities = 698/698 (100%), Positives = 698/698 (100%)
Query: 329 MEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAEN 388
MEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAEN
Sbjct: 1 MEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAEN 60
Query: 389 KHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDIL 448
KHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDIL
Sbjct: 61 KHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDIL 120
Query: 449 KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMD 508
KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMD
Sbjct: 121 KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMD 180
Query: 509 VTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQL 568
VTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQL
Sbjct: 181 VTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQL 240
Query: 569 KHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPIT 628
KHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPIT
Sbjct: 241 KHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPIT 300
Query: 629 MYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRP 688
MYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRP
Sbjct: 301 MYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRP 360
Query: 689 SEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWM 748
SEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWM
Sbjct: 361 SEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWM 420
Query: 749 LTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASI 808
LTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASI
Sbjct: 421 LTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASI 480
Query: 809 FARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLK 868
FARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLK
Sbjct: 481 FARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLK 540
Query: 869 GSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALD 928
GSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALD
Sbjct: 541 GSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALD 600
Query: 929 NESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIR 988
NESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIR
Sbjct: 601 NESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIR 660
Query: 989 IPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL 1026
IPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL
Sbjct: 661 IPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL 698
Score = 82.8 bits (203), Expect = 2e-15
Identities = 79/289 (27%), Positives = 117/289 (40%), Gaps = 36/289 (12%)
Query: 43 EKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTA 102
E+ V C+ G PKP +W NG + T R + +G+L I N + DAG YQC A
Sbjct: 2 EENVFWECKANGRPKPTYKWLKNGEPLLTRD--RIQIEQGTLNITIVNLS-DAGMYQCLA 58
Query: 103 TNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEY 162
N G I S A +F V++ + G V++ P S + Y W
Sbjct: 59 ENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGR- 117
Query: 163 PSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTN-----TVTNHKVLGPPTPLILRND 217
++N R E GNL I V KSD G+YTC+ TN + T + V+ PT +++
Sbjct: 118 DILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVP-- 175
Query: 218 GVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRA----------DGKPI 267
P ++ G ++ L C + I++ + DG
Sbjct: 176 --------------PSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHF 221
Query: 268 ARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQP 316
R + S G L I N Q + AG Y C+ + S + A L P
Sbjct: 222 ERVGGQ-DSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP 269
Score = 62.4 bits (150), Expect = 2e-09
Identities = 67/261 (25%), Positives = 103/261 (39%), Gaps = 26/261 (9%)
Query: 154 SYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLI 213
+Y W+ N P +R + E G L I V SD G Y C+ N H V+ L
Sbjct: 18 TYKWLKNGEPLLTRDR--IQIEQGTLNITIVNLSDAGMYQCLAEN---KHGVIFSNAELS 72
Query: 214 LRNDGVMGEYEPKIEVQFPETVPTAK-GATVKLECFALGNPVPTIIWRRADGKPIARKAR 272
+ G P + V K G V +EC +P P W++ G+ I ++
Sbjct: 73 VIAVG------PDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKK--GRDILKENE 124
Query: 273 RH--KSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAME 330
R +G L I N + DAG Y C+A N G + G L + + + V +
Sbjct: 125 RITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVG 184
Query: 331 ENVFWECKA--NGRPKPTYKWLKNGEPL-LTRDRIQIEQ-------GTLNITIVNLSDAG 380
E++ C+ + + W NG + RD E+ G L I + L AG
Sbjct: 185 ESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAG 244
Query: 381 MYQCLAENKHGVIFSNAELSV 401
Y C+ + + + A+L V
Sbjct: 245 KYVCMVQTSVDRLSAAADLIV 265
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 1305 bits (3377), Expect = 0.0
Identities = 617/1002 (61%), Positives = 775/1002 (77%), Gaps = 4/1002 (0%)
Query: 1 MRLPWELLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHI 60
MRL W+L++L I A D L PIF QEP V+FPLD + +V LNC G P PH
Sbjct: 1 MRLLWKLVILLPLINSSAGDGLLSRPIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHY 60
Query: 61 RWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAY 120
RWK NGTD+D M + Y + GSL IN+P+ QD G YQC ATN GTI+SR+AKLQFAY
Sbjct: 61 RWKQNGTDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAY 120
Query: 121 LDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSY--QDNRRFVSQETGN 178
+++F+T+TRSTVSVR GQG+VLLCGPPPH G+LSYAW FN+ P Y +DNRRFVSQETGN
Sbjct: 121 IEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGN 180
Query: 179 LYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTA 238
LYIAKVE SDVGNYTC +TN V GPPTPL+ R DGVMGEYEPKIEV+FPET+ A
Sbjct: 181 LYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAA 240
Query: 239 KGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAE 298
K ++VKLECFALGNPVP I WRR DG P+ K + KS ILEIPNFQQED G YEC+A
Sbjct: 241 KDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIAS 300
Query: 299 NSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLT 358
N RG+N+A+GQL FYA P W QKI + H+++ +N+ WECKA+G+P P Y WLKNGE L
Sbjct: 301 NLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNP 360
Query: 359 RDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTL 418
+RIQIE GTL IT++N+SD+G+YQC AENK+ +I++NAEL V+A PDFS++ +K+ +
Sbjct: 361 EERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSF 420
Query: 419 VKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCI 478
V+VGG++VI CKP A P+ +WK+G + L++++RI + EDG+L+I N+T+SDAGSYTCI
Sbjct: 421 VQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCI 480
Query: 479 ATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGH 538
ATN FGTA +TG+L+VK+ T + VPPS MDVTVGESIVLPCQV+HD S+++VF W FNG
Sbjct: 481 ATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGD 540
Query: 539 LIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPG 598
+ID + HFER+GG +S GDLMIRNIQL H+GKY+C VQT+++ LSA AD+IVRGPPG
Sbjct: 541 VIDLKKGVAHFERIGG-ESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPPG 599
Query: 599 PPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFT 658
PPE V +++I+ TT+QLSWR GPDN+SPI ++ IQ RTPFSVGWQAV+TVPE+++GKT+
Sbjct: 600 PPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEILNGKTYN 659
Query: 659 ATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVI 718
ATVVGL+PWVEYEFR VA N IGIGEPS PSE RT+ ++P V P N+ GGGGS+SELVI
Sbjct: 660 ATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGGSRSELVI 719
Query: 719 TWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVG 778
TWE++PEELQNG GFGY++ FRP G W ++S ++SR+V+RNES+ P SPFEVKVG
Sbjct: 720 TWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESIIPLSPFEVKVG 779
Query: 779 VFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFW-ASPLEKNRGRIQGYE 837
V+NN+GEG S T+VYS E+EP P +S SA+++EV W A +N GR+ GYE
Sbjct: 780 VYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGYE 839
Query: 838 VKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTR 897
V YW + KE KIR GN T+ IT LK + +Y +V+AYN+AGTGPSS VNVTT+
Sbjct: 840 VLYWTDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASVRAYNTAGTGPSSPPVNVTTK 899
Query: 898 KPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTS 957
K PPSQPP NI W ++SK+ LNW+ VK ++NESEV GYK+LYR NRQS T ++ETN TS
Sbjct: 900 KSPPSQPPANIAWKLTNSKLCLNWEHVKTMENESEVLGYKILYRQNRQSKTHILETNNTS 959
Query: 958 VELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARG 999
EL +PF+EDY+IEI+ SDGGDGSSSE+IRIPK+S+ +RG
Sbjct: 960 AELLVPFEEDYLIEIRTVSDGGDGSSSEEIRIPKMSSLSSRG 1001
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 1161 bits (3004), Expect = 0.0
Identities = 561/1023 (54%), Positives = 730/1023 (71%), Gaps = 11/1023 (1%)
Query: 1 MRLPWELLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHI 60
M W+L++ S +CL++ S +GP+F+QEP ++FP DS+EKKV LNCEV+GNP P
Sbjct: 1 MASSWKLMLFLSVTMCLSE-SVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSY 59
Query: 61 RWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAY 120
RW NGT++D D+RYS+++G+ +I+NP++ +D+G YQC ATN+ G+I+SREA LQFAY
Sbjct: 60 RWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAY 119
Query: 121 LDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSY--QDNRRFVSQETGN 178
L NF RTRS VSVR GQG+VL+C PPPHS E+ Y+W+FNE+PS+ +D+RRF+SQETGN
Sbjct: 120 LGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGN 179
Query: 179 LYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTA 238
LYI+KV+ SDVG+Y C+V NTVTN +VL PPTPL LRNDGVMGEYEPKIEV FP TV A
Sbjct: 180 LYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA 239
Query: 239 KGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAE 298
KG TVK+ECFALGNPVPTI W + +G I KAR KS +LEIPN Q +DAG+YEC AE
Sbjct: 240 KGTTVKMECFALGNPVPTITWMKVNGY-IPSKARLRKSQAVLEIPNVQLDDAGIYECRAE 298
Query: 299 NSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLT 358
NSRGKN RGQL Y P+W++K+ND + + WECKA G+P+PTY+WLKNG PL
Sbjct: 299 NSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSP 358
Query: 359 RDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTL 418
+ R+++ G L I VN SDAGMYQCLAENK+G I+++AEL ++A P F+ LK+ +
Sbjct: 359 QSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTII 418
Query: 419 VKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCI 478
V EVVIECKP+ SPKP +WKKG ++EN+RI I DG+LRI+N +KSD G Y C
Sbjct: 419 VTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCR 478
Query: 479 ATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGH 538
N FG+A +L VK+PTR+ + P ++TVGESIVL C+ HD SLD+ F W+ G
Sbjct: 479 GENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQ 538
Query: 539 LIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPG 598
IDF+ +G HFE + Q S+ DLMIRNI L HAG+Y C VQT+ D +S A+L+VRGPPG
Sbjct: 539 PIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPG 598
Query: 599 PPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFT 658
PP V ++EIT++TA LSW P DNHSPI+ Y +QAR+PFS+GWQ V TVPE+I G +
Sbjct: 599 PPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMES 658
Query: 659 ATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVI 718
A V LNPWVEYEFR VA N IG G+PS PS RT EA+P+ P NVSG G + ELVI
Sbjct: 659 AMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVI 718
Query: 719 TWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVG 778
WE V EE QNG GFGY+VAFRP G W ++ S++AS++++R+ESV P +PFEVKVG
Sbjct: 719 AWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVG 778
Query: 779 VFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEV 838
V+NNKG+GPFS V+ SAE EP+ P + A S+S ++I V W ++++ GR QG+EV
Sbjct: 779 VYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAW-KHIKESLGRPQGFEV 837
Query: 839 KYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRK 898
YW+ ++E+ A ++T GN++ +T L+G+ LYH V+AYN AG GP S+ V+ TT+K
Sbjct: 838 GYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKK 897
Query: 899 PPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSV 958
PPSQ P N+ W S++ L W+ V L NESEV GYKV YR S++ VIET K
Sbjct: 898 SPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQA 957
Query: 959 ELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMI 1018
+ LP YIIE++ +S+GGDG++S QIR+P S G TS TL ++ST
Sbjct: 958 VVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYS------GGKITSAQSTLHSLSTSSS 1011
Query: 1019 SLT 1021
S+T
Sbjct: 1012 SVT 1014
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 1154 bits (2986), Expect = 0.0
Identities = 556/1005 (55%), Positives = 720/1005 (71%), Gaps = 10/1005 (0%)
Query: 19 DDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYS 78
D+S +GP+F+QEP ++FP DS+EKKV LNCEV+GNP P RW NGT++D D+RYS
Sbjct: 92 DESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYS 151
Query: 79 VVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQ 138
+++G+ +I+NP++ +D+G YQC ATN+ G+I+SREA LQFAYL NF RTRS VSVR GQ
Sbjct: 152 LIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQ 211
Query: 139 GMVLLCGPPPHSGELSYAWIFNEYPSY--QDNRRFVSQETGNLYIAKVEKSDVGNYTCVV 196
G+VL+C PPPHS E+ Y+W+FNE+PS+ +D+RRF+SQETGNLYI+KV+ SDVG+Y C+V
Sbjct: 212 GVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLV 271
Query: 197 TNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPT 256
NTVTN +VL PPTPL LRNDGVMGEYEPKIEV FP TV AKG TVK+ECFALGNPVPT
Sbjct: 272 KNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPT 331
Query: 257 IIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQP 316
I W + +G I KAR KS +LEIPN Q +DAG+YEC AENSRGKN RGQL Y P
Sbjct: 332 ITWMKVNGY-IPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYP 390
Query: 317 NWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNL 376
+W++K+ND + + WECKA G+P+PTY+WLKNG PL + R+++ G L I VN
Sbjct: 391 HWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQ 450
Query: 377 SDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPK 436
SDAGMYQCLAENK+G I+++AEL ++A P F+ LK+ +V EVVIECKP+ SPK
Sbjct: 451 SDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPK 510
Query: 437 PVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD 496
P +WKKG ++EN+RI I DG+LRI+N +KSD G Y C N FG+A +L VK+
Sbjct: 511 PTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE 570
Query: 497 PTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQD 556
PTR+ + P ++TVGESIVL C+ HD SLD+ F W+ G IDF+ +G HFE + Q
Sbjct: 571 PTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQA 630
Query: 557 SAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLS 616
S+ DLMIRNI L HAG+Y C VQT+ D +S A+L+VRGPPGPP V ++EIT++TA LS
Sbjct: 631 SSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLS 690
Query: 617 WRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVA 676
W P DNHSPI+ Y +QAR+PFS+GWQ V TVPE+I G +A V LNPWVEYEFR VA
Sbjct: 691 WSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVA 750
Query: 677 ANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYV 736
N IG G+PS PS RT EA+P+ P NVSG G + ELVI WE V EE QNG GFGY+
Sbjct: 751 TNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYI 810
Query: 737 VAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYS 796
VAFRP G W ++ S++AS++++R+ESV P +PFEVKVGV+NNKG+GPFS V+ S
Sbjct: 811 VAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICS 870
Query: 797 AEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTV 856
AE EP+ P + A S+S ++I V W ++++ GR QG+EV YW+ ++E+ A ++T
Sbjct: 871 AEGEPSAAPTDVKATSVSVSEILVAW-KHIKESLGRPQGFEVGYWKDMEQEDTAETVKTR 929
Query: 857 GNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSK 916
GN++ +T L+G+ LYH V+AYN AG GP S+ V+ TT+K PPSQ P N+ W S+
Sbjct: 930 GNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQ 989
Query: 917 IILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFS 976
+ L W+ V L NESEV GYKV YR S++ VIET K + LP YIIE++ +S
Sbjct: 990 VSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYS 1049
Query: 977 DGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMISLT 1021
+GGDG++S QIR+P S G TS TL ++ST S+T
Sbjct: 1050 EGGDGTASSQIRVPSYS------GGKITSAQSTLHSLSTSSSSVT 1088
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 897 bits (2319), Expect = 0.0
Identities = 431/969 (44%), Positives = 617/969 (63%), Gaps = 9/969 (0%)
Query: 22 TLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVE 81
T GP+F +P V+FP +S E++V L C + +P RWK+NGT++ R+ +V
Sbjct: 33 TTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVG 92
Query: 82 GSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMV 141
G+L+I NP K QDAG YQC A+N GT+VSREA L+F +L F R V G G++
Sbjct: 93 GNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVM 152
Query: 142 LLCGPPPHSGELSYAWIFNEYPSY--QDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNT 199
L C PP H LSY W+ NE+P++ D R FVSQ TGNLYIA+ SD+GNY+C+ T+
Sbjct: 153 LPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSH 212
Query: 200 V--TNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTI 257
+ + V L L + + P I+ +FP G V LECFA GNPVP I
Sbjct: 213 MDFSTKSVFSKFAQLNLAAEDTR-LFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRI 271
Query: 258 IWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPN 317
WR+ DG + + + L+IP+ ED G YEC AENS+G++ +G++ AQP
Sbjct: 272 KWRKVDG---SLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPE 328
Query: 318 WIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLS 377
W++ I+D + N+ W C A G+P+PT +WL+NGEPL +++R+++ G L + ++L
Sbjct: 329 WLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKLSLE 388
Query: 378 DAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKP 437
D+GMYQC+AENKHG I+++AEL+V A+ PDF ++R+ GGE++I C+P+A+PK
Sbjct: 389 DSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKA 448
Query: 438 VYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDP 497
V W KG +IL + R+T++ DG L I N+++SD G YTC A N G A+STG L V+D
Sbjct: 449 VVLWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDA 508
Query: 498 TRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDS 557
T++ + PSS D+ +G+++ L C +HD ++D+ FTW+ + IDFD+ G H+ R +++
Sbjct: 509 TKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKET 568
Query: 558 AGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSW 617
GDL I N QL+H GKY CM QT VD S A ++VRGPPGPP V + +I DTT QLSW
Sbjct: 569 IGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSW 628
Query: 618 RPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAA 677
G DNHSPI Y +QARTP + W+ V T P I+G TA V+GL PW++YEFR +A+
Sbjct: 629 SRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIAS 688
Query: 678 NVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVV 737
N++G GEPS PS K RT EA P V P+ +SGGGG+ EL++ W + E QNG GFGY++
Sbjct: 689 NILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLL 748
Query: 738 AFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSA 797
+FR G W + ADA +V+ NESV P++PFEVK+ +N +G+GP S T +VYSA
Sbjct: 749 SFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSA 808
Query: 798 EEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVG 857
EEEP P ++A+ +S++++ V W + G + GYE++YW+ DKE A ++RT G
Sbjct: 809 EEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAG 868
Query: 858 NQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKI 917
TS +++ L + YH+ V+AYN AGTGP+S + N TT KPPP +PPGNI W S S +
Sbjct: 869 LDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSL 928
Query: 918 ILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDY-IIEIKPFS 976
+ WD V NES V GYK+LY+ + + ++ T K +E+ +P D + +++I+
Sbjct: 929 SIKWDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLTGKNWIEIPVPEDIGHALVQIRTTG 988
Query: 977 DGGDGSSSE 985
GGDG +E
Sbjct: 989 PGGDGIPAE 997
>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
Length = 1007
Score = 878 bits (2268), Expect = 0.0
Identities = 445/983 (45%), Positives = 612/983 (62%), Gaps = 19/983 (1%)
Query: 8 LVLQSFILCLA--DDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLN 65
LV+ S CLA ++ GPIF ++P ++P +S E KV LNC + +P P +W++N
Sbjct: 10 LVIISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMN 69
Query: 66 GTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFK 125
DVD D RYS+V G+L+INNP+K +DAG Y C A+N++G + S EA L F YLD F
Sbjct: 70 NGDVDLTSD-RYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFP 128
Query: 126 TRTRSTVSVRRGQGMVLLCGPPPH-SGELSYAWIFNEYPSY--QDNRRFVSQETGNLYIA 182
R V V+ G+GMVLLC PP H +LSY W+ NE+P + D RRFVSQ GNLYIA
Sbjct: 129 PEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIA 188
Query: 183 KVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGAT 242
VE SD GNY+C V++ V PLI + Y I VQF + V G
Sbjct: 189 NVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKD-VYALMGQN 247
Query: 243 VKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRG 302
V LECFALGNPVP I WR+ +P+ A S +L+I N Q ED G+YEC AEN RG
Sbjct: 248 VTLECFALGNPVPDIRWRKVL-EPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRG 306
Query: 303 KNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRI 362
K+ + ++ A P W++ IND V + +++W C A G+P PT +WLKNG
Sbjct: 307 KDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNG--------Y 358
Query: 363 QIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVG 422
+G L + V +AGMYQC+AEN +G I++NAEL ++A+ P F +K+ L G
Sbjct: 359 AYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKG 418
Query: 423 GEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNH 482
G V+IECKPKA+PKP ++W KG + L + RI I EDG+L I N+T++D G YTC A N+
Sbjct: 419 GRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENN 478
Query: 483 FGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDF 542
G A+STG LV+ DPTR+++ P + D+TVGE+ + C + D +LD+ F WSFNG++IDF
Sbjct: 479 RGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDF 538
Query: 543 DRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEA 602
+++ H++R DS G+L+IRN QLKHAG+Y C QT VD SA+ADL+VRGPPGPP
Sbjct: 539 NKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGG 598
Query: 603 VTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVV 662
+ I++I T+ L+W G DNHSPI+ Y IQ +T S W+ T P +I+G A V
Sbjct: 599 LRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAV 658
Query: 663 GLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWET 722
L PW+EYEFR VA N +G GEPS PS + +T+ A P V P++V GGGG EL ITW
Sbjct: 659 DLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAP 718
Query: 723 VPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNN 782
+ E G FGY+VAF+P+ W + + D RYV ++E++ P + F+VKV FNN
Sbjct: 719 LSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNN 778
Query: 783 KGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWR 842
KG+GP+S V+ SA++ P++ P + + LS+++I V W LEK ++ Y+++YW
Sbjct: 779 KGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEK---IVESYQIRYWA 835
Query: 843 HEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPS 902
DKEE A +++ + S ++ NL Y + V A NSAG GP S + T+K PPS
Sbjct: 836 AHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPS 895
Query: 903 QPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSL 962
QPP I S S+ I+ WD V AL NES V GYKVLYR + Q + T+K S+E+ +
Sbjct: 896 QPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPI 955
Query: 963 PFDEDYIIEIKPFSDGGDGSSSE 985
P D +Y++E++ SDGGDG S+
Sbjct: 956 PRDGEYVVEVRAHSDGGDGVVSQ 978
>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
Length = 1018
Score = 874 bits (2257), Expect = 0.0
Identities = 439/964 (45%), Positives = 603/964 (62%), Gaps = 17/964 (1%)
Query: 25 GPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSL 84
GPIF ++P ++P +S E KV LNC + +P P +W++N DVD D RYS+V G+L
Sbjct: 40 GPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSD-RYSMVGGNL 98
Query: 85 LINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLC 144
+INNP+K +DAG Y C A+N++G + S EA L F YLD F R V V+ G+GMVLLC
Sbjct: 99 VINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLC 158
Query: 145 GPPPH-SGELSYAWIFNEYPSY--QDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVT 201
PP H +LSY W+ NE+P + D RRFVSQ GNLYIA VE SD GNY+C V++
Sbjct: 159 DPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSI 218
Query: 202 NHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRR 261
V PLI + Y I VQF + V G V LECFALGNPVP I WR+
Sbjct: 219 TKSVFSKFIPLIPIPERTTKPYPADIVVQFKD-VYALMGQNVTLECFALGNPVPDIRWRK 277
Query: 262 ADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQK 321
+P+ A S +L+I N Q ED G+YEC AEN RGK+ + ++ A P W++
Sbjct: 278 VL-EPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEH 336
Query: 322 INDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGM 381
IND V + +++W C A G+P PT +WLKNG +G L + V +AGM
Sbjct: 337 INDTEVDIGSDLYWPCVATGKPIPTIRWLKNG--------YAYHKGELRLYDVTFENAGM 388
Query: 382 YQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTW 441
YQC+AEN +G I++NAEL ++A+ P F +K+ L GG V+IECKPKA+PKP ++W
Sbjct: 389 YQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSW 448
Query: 442 KKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVM 501
KG + L + RI I EDG+L I N+T++D G YTC A N+ G A+STG LV+ DPTR++
Sbjct: 449 SKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRII 508
Query: 502 VPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDL 561
+ P + D+TVGE+ + C + D +LD+ F WSFNG++IDF+++ H++R DS G+L
Sbjct: 509 LAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGEL 568
Query: 562 MIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGP 621
+IRN QLKHAG+Y C QT VD SA+ADL+VRGPPGPP + I++I T+ L+W G
Sbjct: 569 LIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGS 628
Query: 622 DNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIG 681
DNHSPI+ Y IQ +T S W+ T P +I+G A V L PW+EYEFR VA N +G
Sbjct: 629 DNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLG 688
Query: 682 IGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRP 741
GEPS PS + +T+ A P V P++V GGGG EL ITW + E G FGY+VAF+P
Sbjct: 689 RGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKP 748
Query: 742 YGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEP 801
+ W + + D RYV ++E++ P + F+VKV FNNKG+GP+S V+ SA++ P
Sbjct: 749 FDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAP 808
Query: 802 TKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTS 861
++ P + + LS+++I V W LEK ++ Y+++YW DKEE A +++ + S
Sbjct: 809 SEAPTEVGVKVLSSSEISVHWEHVLEK---IVESYQIRYWAAHDKEEAANRVQVTSQEYS 865
Query: 862 TKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNW 921
++ NL Y + V A NSAG GP S + T+K PPSQPP I S S+ I+ W
Sbjct: 866 ARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITW 925
Query: 922 DQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDG 981
D V AL NES V GYKVLYR + Q + T+K S+E+ +P D +Y++E++ SDGGDG
Sbjct: 926 DHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGDG 985
Query: 982 SSSE 985
S+
Sbjct: 986 VVSQ 989
>gi|28373124 contactin 4 isoform b precursor [Homo sapiens]
Length = 282
Score = 563 bits (1452), Expect = e-160
Identities = 282/282 (100%), Positives = 282/282 (100%)
Query: 745 MIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKP 804
MIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKP
Sbjct: 1 MIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKP 60
Query: 805 PASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKI 864
PASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKI
Sbjct: 61 PASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKI 120
Query: 865 TNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQV 924
TNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQV
Sbjct: 121 TNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQV 180
Query: 925 KALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSS 984
KALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSS
Sbjct: 181 KALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSS 240
Query: 985 EQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL 1026
EQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL
Sbjct: 241 EQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL 282
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 383 bits (983), Expect = e-106
Identities = 286/973 (29%), Positives = 446/973 (45%), Gaps = 60/973 (6%)
Query: 1 MRLPWELLVLQSFILCLADDSTLHGPIFIQEPSP---VMFPLDSEEKKVKLNCEVKGNPK 57
+R W LL+ +L + + P+ I E SP V+FP D + L CE G P+
Sbjct: 5 LRYVWPLLLCSPCLLIQIPEELMEPPV-ITEQSPRRLVVFPTDD----ISLKCEASGKPE 59
Query: 58 PHIRWKLNGTDV----DTGMDFRYSVVEGSLLI--NNPNKTQD-AGTYQCTATNSFGTIV 110
RW +G + G+ S GS I NN N Q G Y+C A+N GT +
Sbjct: 60 VQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAM 119
Query: 111 SREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRR 170
S E +L + T V V G+ +VL C PPP + L W+ ++ + + R
Sbjct: 120 SHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDER 179
Query: 171 FVSQETGNLYIAKVEKSDV-GNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEV 229
+ GNLY A V SD +Y C T + P L ++ M + +P++
Sbjct: 180 VTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRL-- 237
Query: 230 QFPET----VPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNF 285
FP + +G + LEC A G P PTI W R G A + N L++
Sbjct: 238 LFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKV 297
Query: 286 QQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKP 345
+ED G Y C+AENS G +T A P W+ K E +C+ GRP+P
Sbjct: 298 GEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQP 357
Query: 346 TYKWLKNGEPL--LTRD-RIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVI 402
W NG P+ L +D + +I++G L ++ V SD + QC A N+HG++ +NA + V+
Sbjct: 358 EVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVV 417
Query: 403 AVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTW--KKGRDILKENERITISEDG 460
+ P T + + G + CK +P P W + G +L ++ER +G
Sbjct: 418 QL-PAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL-QDERFFPYANG 475
Query: 461 NLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQ 520
L I ++ +D G Y C+A N + NL VKD T++ P S G + CQ
Sbjct: 476 TLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQ 535
Query: 521 VTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQT 580
+ D SL TW +G + D D + G+ L+I ++ G Y C+ T
Sbjct: 536 ASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGR-----LVIHSLDYSDQGNYSCVAST 590
Query: 581 SVDRLSAAADLIVRGPPGPPEAVTIDE---ITDTTAQLSWRPGPDNHSPITMYVI--QAR 635
+D + + A L+V G PGP + + + +T + ++SW P D+++PI Y I + +
Sbjct: 591 ELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDK 650
Query: 636 TPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTE 695
W ++ VP T+T + L+P+V Y FR A N G GEPS SE T
Sbjct: 651 EMAPEKWYSLGKVP-----GNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTP 705
Query: 696 EALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYG-KMIWMLTVLAS 754
EA PE P +V G G + +VITW+ + N Y V +RP G + W +++
Sbjct: 706 EAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSD 765
Query: 755 ADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLS 814
V N S F P+E+KV N++G+GP T+ YS E+ P P L+
Sbjct: 766 ---PFLVVSNTST--FVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILN 820
Query: 815 ATDIEVFWAS-PLEKNRGRIQGYEVKYWRHEDKEENARK------IRTVGNQTSTKITNL 867
++ + V W L + +G ++GY V YWR + +++++ + N TS ++ L
Sbjct: 821 SSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGL 880
Query: 868 KGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKAL 927
+ YHL V+A+N G+GP+S +T + P P + S++ ++L W L
Sbjct: 881 RPYSSYHLEVQAFNGRGSGPAS-EFTFSTPEGVPGHPEALHLECQSNTSLLLRWQ--PPL 937
Query: 928 DNESEVKGYKVLY 940
+ + GY + Y
Sbjct: 938 SHNGVLTGYVLSY 950
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 377 bits (969), Expect = e-104
Identities = 286/977 (29%), Positives = 445/977 (45%), Gaps = 63/977 (6%)
Query: 1 MRLPWELLVLQSFILCLADDST----LHGPIFIQEPSP---VMFPLDSEEKKVKLNCEVK 53
+R W LL+ +L + + P I E SP V+FP D + L CE
Sbjct: 5 LRYVWPLLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDD----ISLKCEAS 60
Query: 54 GNPKPHIRWKLNGTDV----DTGMDFRYSVVEGSLLI--NNPNKTQD-AGTYQCTATNSF 106
G P+ RW +G + G+ S GS I NN N Q G Y+C A+N
Sbjct: 61 GKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKL 120
Query: 107 GTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQ 166
GT +S E +L + T V V G+ +VL C PPP + L W+ ++ +
Sbjct: 121 GTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIK 180
Query: 167 DNRRFVSQETGNLYIAKVEKSDV-GNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEP 225
+ R + GNLY A V SD +Y C T + P L ++ M + +P
Sbjct: 181 QDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKP 240
Query: 226 KIEVQFPET----VPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILE 281
++ FP + +G + LEC A G P PTI W R G A + N L+
Sbjct: 241 RL--LFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQ 298
Query: 282 IPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANG 341
+ +ED G Y C+AENS G +T A P W+ K E +C+ G
Sbjct: 299 LLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQG 358
Query: 342 RPKPTYKWLKNGEPL--LTRD-RIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAE 398
RP+P W NG P+ L +D + +I++G L ++ V SD + QC A N+HG++ +NA
Sbjct: 359 RPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAY 418
Query: 399 LSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTW--KKGRDILKENERITI 456
+ V+ + P T + + G + CK +P P W + G +L ++ER
Sbjct: 419 IYVVQL-PAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL-QDERFFP 476
Query: 457 SEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIV 516
+G L I ++ +D G Y C+A N + NL VKD T++ P S G +
Sbjct: 477 YANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVT 536
Query: 517 LPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVC 576
CQ + D SL TW +G + D D + G+ L+I ++ G Y C
Sbjct: 537 FTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGR-----LVIHSLDYSDQGNYSC 591
Query: 577 MVQTSVDRLSAAADLIVRGPPGPPEAVTIDE---ITDTTAQLSWRPGPDNHSPITMYVI- 632
+ T +D + + A L+V G PGP + + + +T + ++SW P D+++PI Y I
Sbjct: 592 VASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIE 651
Query: 633 -QARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEK 691
+ + W ++ VP T+T + L+P+V Y FR A N G GEPS SE
Sbjct: 652 FEDKEMAPEKWYSLGKVP-----GNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSET 706
Query: 692 RRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYG-KMIWMLT 750
T EA PE P +V G G + +VITW+ + N Y V +RP G + W
Sbjct: 707 VVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQ 766
Query: 751 VLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFA 810
+++ V N S F P+E+KV N++G+GP T+ YS E+ P P
Sbjct: 767 IVSD---PFLVVSNTST--FVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGI 821
Query: 811 RSLSATDIEVFWAS-PLEKNRGRIQGYEVKYWRHEDKEENARK------IRTVGNQTSTK 863
L+++ + V W L + +G ++GY V YWR + +++++ + N TS
Sbjct: 822 EILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI 881
Query: 864 ITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQ 923
++ L+ YHL V+A+N G+GP+S +T + P P + S++ ++L W
Sbjct: 882 LSGLRPYSSYHLEVQAFNGRGSGPAS-EFTFSTPEGVPGHPEALHLECQSNTSLLLRWQ- 939
Query: 924 VKALDNESEVKGYKVLY 940
L + + GY + Y
Sbjct: 940 -PPLSHNGVLTGYVLSY 955
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 377 bits (969), Expect = e-104
Identities = 286/977 (29%), Positives = 445/977 (45%), Gaps = 63/977 (6%)
Query: 1 MRLPWELLVLQSFILCLADDST----LHGPIFIQEPSP---VMFPLDSEEKKVKLNCEVK 53
+R W LL+ +L + + P I E SP V+FP D + L CE
Sbjct: 5 LRYVWPLLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDD----ISLKCEAS 60
Query: 54 GNPKPHIRWKLNGTDV----DTGMDFRYSVVEGSLLI--NNPNKTQD-AGTYQCTATNSF 106
G P+ RW +G + G+ S GS I NN N Q G Y+C A+N
Sbjct: 61 GKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKL 120
Query: 107 GTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQ 166
GT +S E +L + T V V G+ +VL C PPP + L W+ ++ +
Sbjct: 121 GTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIK 180
Query: 167 DNRRFVSQETGNLYIAKVEKSDV-GNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEP 225
+ R + GNLY A V SD +Y C T + P L ++ M + +P
Sbjct: 181 QDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKP 240
Query: 226 KIEVQFPET----VPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILE 281
++ FP + +G + LEC A G P PTI W R G A + N L+
Sbjct: 241 RL--LFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQ 298
Query: 282 IPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANG 341
+ +ED G Y C+AENS G +T A P W+ K E +C+ G
Sbjct: 299 LLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQG 358
Query: 342 RPKPTYKWLKNGEPL--LTRD-RIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAE 398
RP+P W NG P+ L +D + +I++G L ++ V SD + QC A N+HG++ +NA
Sbjct: 359 RPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAY 418
Query: 399 LSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTW--KKGRDILKENERITI 456
+ V+ + P T + + G + CK +P P W + G +L ++ER
Sbjct: 419 IYVVQL-PAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL-QDERFFP 476
Query: 457 SEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIV 516
+G L I ++ +D G Y C+A N + NL VKD T++ P S G +
Sbjct: 477 YANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVT 536
Query: 517 LPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVC 576
CQ + D SL TW +G + D D + G+ L+I ++ G Y C
Sbjct: 537 FTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGR-----LVIHSLDYSDQGNYSC 591
Query: 577 MVQTSVDRLSAAADLIVRGPPGPPEAVTIDE---ITDTTAQLSWRPGPDNHSPITMYVI- 632
+ T +D + + A L+V G PGP + + + +T + ++SW P D+++PI Y I
Sbjct: 592 VASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIE 651
Query: 633 -QARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEK 691
+ + W ++ VP T+T + L+P+V Y FR A N G GEPS SE
Sbjct: 652 FEDKEMAPEKWYSLGKVP-----GNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSET 706
Query: 692 RRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYG-KMIWMLT 750
T EA PE P +V G G + +VITW+ + N Y V +RP G + W
Sbjct: 707 VVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQ 766
Query: 751 VLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFA 810
+++ V N S F P+E+KV N++G+GP T+ YS E+ P P
Sbjct: 767 IVSD---PFLVVSNTST--FVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGI 821
Query: 811 RSLSATDIEVFWAS-PLEKNRGRIQGYEVKYWRHEDKEENARK------IRTVGNQTSTK 863
L+++ + V W L + +G ++GY V YWR + +++++ + N TS
Sbjct: 822 EILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI 881
Query: 864 ITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQ 923
++ L+ YHL V+A+N G+GP+S +T + P P + S++ ++L W
Sbjct: 882 LSGLRPYSSYHLEVQAFNGRGSGPAS-EFTFSTPEGVPGHPEALHLECQSNTSLLLRWQ- 939
Query: 924 VKALDNESEVKGYKVLY 940
L + + GY + Y
Sbjct: 940 -PPLSHNGVLTGYVLSY 955
>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
Length = 1174
Score = 365 bits (938), Expect = e-101
Identities = 283/971 (29%), Positives = 433/971 (44%), Gaps = 81/971 (8%)
Query: 4 PWELLVLQSFILCLAD-DSTLHGPIFIQEPSPVMFPLDSEE-----KKVKLNCEVKGNPK 57
PW V +F+LCL + P+ + +P + + + + CE KGNP
Sbjct: 8 PW---VHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPA 64
Query: 58 PHIRWKLNGTDVDTGMDFRYSVVE--GSLLIN---NPNKTQDAGTYQCTATNSFGTIVSR 112
P W N + D R S+ G+L+I+ + G YQC A N FGT +S
Sbjct: 65 PSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN 124
Query: 113 EAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFV 172
+LQ + + V V+ G + L C PPP W+ + ++R
Sbjct: 125 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVS 184
Query: 173 SQETGNLYIAKVEKSDVG-NYTCVV----TNTV-----------TNHKVLGPPTPLILRN 216
G+LY + V D+ +Y+C T+T+ TNH P LRN
Sbjct: 185 QGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNH----PYNDSSLRN 240
Query: 217 DGVM----GEYEPKIEVQFPETVPTA----KGATVKLECFALGNPVPTIIWRRADGKPIA 268
M G E +P+ ++ +G + LEC A G P P I W + G +
Sbjct: 241 HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 300
Query: 269 RKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVA 328
KA+ N L I N +ED+G Y C+A N G + A P W+ + ++ +A
Sbjct: 301 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 360
Query: 329 MEENVFWECKANGRPKPTYKWLKNGEPLLT---RDRIQIEQGTLNITIVNLSDAGMYQCL 385
E+ C+ANG PKPT +W+ NGEPL + ++ T+ +S +YQC
Sbjct: 361 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 420
Query: 386 AENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTW-K 442
N+HG + +NA +SV+ V P R L R L++V ++C SP P W K
Sbjct: 421 TSNEHGYLLANAFVSVLDVPP---RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFK 477
Query: 443 KGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMV 502
G+ + + E+G+L I + K D G YTC+ATN G A + L VKDPTR+
Sbjct: 478 NGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR 537
Query: 503 PPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLM 562
P G ++ L C+V HD SL + +W + D R+ +D + L
Sbjct: 538 MPEDQVARRGTTVQLECRVKHDPSLKLTVSW------LKDDEPLYIGNRMKKEDDS--LT 589
Query: 563 IRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPD 622
I + + G Y C+ T +D+ A A L V G P P + + ++ + + +L+W PG
Sbjct: 590 IFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDA 649
Query: 623 NHSPITMYVIQ-ARTPFSVG-WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVI 680
N+SPIT YV+Q F G W S P ++ + V+ L+P+V Y+FR +A N +
Sbjct: 650 NNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN-----SAVLRLSPYVNYQFRVIAINEV 704
Query: 681 GIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAF- 739
G PS PSE+ RT A PE P +V G G K+ + ITW + G Y+V +
Sbjct: 705 GSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWR 764
Query: 740 RPYGKMIW-MLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAE 798
R + W +TV SRYV V + P+E++V N+ G+GP + + YS E
Sbjct: 765 RRETREAWNNVTVW----GSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPESVIGYSGE 818
Query: 799 EEPTKPPASIFARSLSATDIEVFWASPLEKN-RGRIQGYEVKYWRHEDKEEN------AR 851
+ P P + R +++T I + W +G+++ Y YWR +N +
Sbjct: 819 DYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQ 878
Query: 852 KIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWN 911
+ G++ ++ L Y L + N G GP S T TT + PS P +
Sbjct: 879 QASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQ 938
Query: 912 SSDSKIILNWD 922
+ I L WD
Sbjct: 939 PNLETINLEWD 949
>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
Length = 1169
Score = 365 bits (938), Expect = e-101
Identities = 283/971 (29%), Positives = 433/971 (44%), Gaps = 81/971 (8%)
Query: 4 PWELLVLQSFILCLAD-DSTLHGPIFIQEPSPVMFPLDSEE-----KKVKLNCEVKGNPK 57
PW V +F+LCL + P+ + +P + + + + CE KGNP
Sbjct: 8 PW---VHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPA 64
Query: 58 PHIRWKLNGTDVDTGMDFRYSVVE--GSLLIN---NPNKTQDAGTYQCTATNSFGTIVSR 112
P W N + D R S+ G+L+I+ + G YQC A N FGT +S
Sbjct: 65 PSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN 124
Query: 113 EAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFV 172
+LQ + + V V+ G + L C PPP W+ + ++R
Sbjct: 125 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVS 184
Query: 173 SQETGNLYIAKVEKSDVG-NYTCVV----TNTV-----------TNHKVLGPPTPLILRN 216
G+LY + V D+ +Y+C T+T+ TNH P LRN
Sbjct: 185 QGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNH----PYNDSSLRN 240
Query: 217 DGVM----GEYEPKIEVQFPETVPTA----KGATVKLECFALGNPVPTIIWRRADGKPIA 268
M G E +P+ ++ +G + LEC A G P P I W + G +
Sbjct: 241 HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 300
Query: 269 RKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVA 328
KA+ N L I N +ED+G Y C+A N G + A P W+ + ++ +A
Sbjct: 301 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 360
Query: 329 MEENVFWECKANGRPKPTYKWLKNGEPLLT---RDRIQIEQGTLNITIVNLSDAGMYQCL 385
E+ C+ANG PKPT +W+ NGEPL + ++ T+ +S +YQC
Sbjct: 361 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 420
Query: 386 AENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTW-K 442
N+HG + +NA +SV+ V P R L R L++V ++C SP P W K
Sbjct: 421 TSNEHGYLLANAFVSVLDVPP---RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFK 477
Query: 443 KGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMV 502
G+ + + E+G+L I + K D G YTC+ATN G A + L VKDPTR+
Sbjct: 478 NGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR 537
Query: 503 PPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLM 562
P G ++ L C+V HD SL + +W + D R+ +D + L
Sbjct: 538 MPEDQVARRGTTVQLECRVKHDPSLKLTVSW------LKDDEPLYIGNRMKKEDDS--LT 589
Query: 563 IRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPD 622
I + + G Y C+ T +D+ A A L V G P P + + ++ + + +L+W PG
Sbjct: 590 IFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDA 649
Query: 623 NHSPITMYVIQ-ARTPFSVG-WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVI 680
N+SPIT YV+Q F G W S P ++ + V+ L+P+V Y+FR +A N +
Sbjct: 650 NNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN-----SAVLRLSPYVNYQFRVIAINEV 704
Query: 681 GIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAF- 739
G PS PSE+ RT A PE P +V G G K+ + ITW + G Y+V +
Sbjct: 705 GSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWR 764
Query: 740 RPYGKMIW-MLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAE 798
R + W +TV SRYV V + P+E++V N+ G+GP + + YS E
Sbjct: 765 RRETREAWNNVTVW----GSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPESVIGYSGE 818
Query: 799 EEPTKPPASIFARSLSATDIEVFWASPLEKN-RGRIQGYEVKYWRHEDKEEN------AR 851
+ P P + R +++T I + W +G+++ Y YWR +N +
Sbjct: 819 DYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQ 878
Query: 852 KIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWN 911
+ G++ ++ L Y L + N G GP S T TT + PS P +
Sbjct: 879 QASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQ 938
Query: 912 SSDSKIILNWD 922
+ I L WD
Sbjct: 939 PNLETINLEWD 949
>gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo
sapiens]
Length = 1183
Score = 358 bits (919), Expect = 1e-98
Identities = 299/1049 (28%), Positives = 451/1049 (42%), Gaps = 89/1049 (8%)
Query: 7 LLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNG 66
+L L I L L P I + SP + +D E V + CE KG P P W NG
Sbjct: 20 ILFLCQMISALEVPLDLVQPPTITQQSPKDYIIDPRENIV-IQCEAKGKPPPSFSWTRNG 78
Query: 67 TDVDTGMDFRYSVVEGS--LLIN--NPNKTQD-AGTYQCTATNSFGTIVSREAKLQFAYL 121
T D D ++ G+ L+IN + K + G YQCTA N G VS ++ +
Sbjct: 79 THFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRS 138
Query: 122 DNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYI 181
+ ++++ GQ +VL C PP W+ N + + R G+LY
Sbjct: 139 PLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYF 198
Query: 182 AKVEKSDVG-NYTCVV----TNTVTNHKVLGPPTPLILR-NDGVMGE------YEPKIEV 229
+ V D +Y C T T+ + + + ND + Y K
Sbjct: 199 SNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSR 258
Query: 230 QFPETVPTA----------KGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGI 279
+ P T T +G + LEC A G P P I W + DG +
Sbjct: 259 ERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKT 318
Query: 280 LEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKA 339
L+I + + D+G Y+C+A+N+ G + A P WI ++ ++ E+ C+A
Sbjct: 319 LQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRA 378
Query: 340 NGRPKPTYKWLKNGEPL-LTRD--RIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSN 396
NG PKP WL NG P+ + D +I+ T+ + V + +YQC A N++G + +N
Sbjct: 379 NGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLAN 438
Query: 397 AELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTWKKGRDILKENERI 454
A ++V+A P R L TL +V +++C SP P W KG +E I
Sbjct: 439 AFVNVLAEPP---RILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDI 495
Query: 455 -TISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGE 513
+ E+G L I K G+YTC+A N G A + +L +KDPT ++ P V G
Sbjct: 496 YVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGS 555
Query: 514 SIVLPCQVTHDHSLDIVFTWSFNGHLIDFDR----DGDHFERVGGQDSAGDLMIRNIQLK 569
+ C+V HDH+L + W + + D D DH L++ ++
Sbjct: 556 MVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDH------------LVVADVSDD 603
Query: 570 HAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITM 629
+G Y C+ T++D +SA+A L V P PP + + + D + QLSW PG DN+SPIT
Sbjct: 604 DSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITK 663
Query: 630 YVIQARTPFSVG--WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSR 687
++I+ W + V T T + L+P+V Y FR +A N IG PS
Sbjct: 664 FIIEYEDAMHKPGLWHHQTEV-----SGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSE 718
Query: 688 PSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPY-GKMI 746
SE+ T+ + P+ P V G G LVITW+ + NG G Y V++R G
Sbjct: 719 ASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDE 778
Query: 747 WMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPA 806
W T + A+ S+Y+ F P+ +KV N+ G P + +S E+ P P
Sbjct: 779 W--TSVVVANVSKYIV--SGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPG 834
Query: 807 SIFARSLSATDIEVFW-ASPLEKNRGRIQGYEVKYWRHEDKEENAR-----KIRTV-GNQ 859
++ +++T EV W PL+ RG +QGY + YW+ + + R KI T G++
Sbjct: 835 NVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSK 894
Query: 860 TSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIIL 919
T + L+ Y L V+ N G GP+S T + PS P I N + + L
Sbjct: 895 THGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTL 954
Query: 920 NWDQVKALDNESEVKGYKVLYRWNRQSSTSV----------IETNKTSVEL-SLPFDEDY 968
WD S G Y Q S I NKT L +L F Y
Sbjct: 955 EWDP------PSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRY 1008
Query: 969 IIEIKPFSDGGDGSSSEQIRIPKISNAYA 997
+ G GS + + + A A
Sbjct: 1009 KFYFYAQTSAGSGSQITEEAVTTVDEAMA 1037
>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
Length = 1189
Score = 357 bits (916), Expect = 3e-98
Identities = 283/986 (28%), Positives = 434/986 (44%), Gaps = 96/986 (9%)
Query: 4 PWELLVLQSFILCLAD-DSTLHGPIFIQEPSPVMFPLDSEE-----KKVKLNCEVKGNPK 57
PW V +F+LCL + P+ + +P + + + + CE KGNP
Sbjct: 8 PW---VHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPA 64
Query: 58 PHIRWKLNGTDVDTGMDFRYSVVE--GSLLIN---NPNKTQDAGTYQCTATNSFGTIVSR 112
P W N + D R S+ G+L+I+ + G YQC A N FGT +S
Sbjct: 65 PSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN 124
Query: 113 EAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFV 172
+LQ + + V V+ G + L C PPP W+ + ++R
Sbjct: 125 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVS 184
Query: 173 SQETGNLYIAKVEKSDVG-NYTCVV----TNTV-----------TNHKVLGPPTPLILRN 216
G+LY + V D+ +Y+C T+T+ TNH P LRN
Sbjct: 185 QGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNH----PYNDSSLRN 240
Query: 217 DGVM----GEYEPKIEVQFPETVPTA----KGATVKLECFALGNPVPTIIWRRADGKPIA 268
M G E +P+ ++ +G + LEC A G P P I W + G +
Sbjct: 241 HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 300
Query: 269 RKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVA 328
KA+ N L I N +ED+G Y C+A N G + A P W+ + ++ +A
Sbjct: 301 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 360
Query: 329 MEENVFWECKANGRPKPTYKWLKNGEPLLT---RDRIQIEQGTLNITIVNLSDAGMYQCL 385
E+ C+ANG PKPT +W+ NGEPL + ++ T+ +S +YQC
Sbjct: 361 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 420
Query: 386 AENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTW-K 442
N+HG + +NA +SV+ V P R L R L++V ++C SP P W K
Sbjct: 421 TSNEHGYLLANAFVSVLDVPP---RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFK 477
Query: 443 KGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMV 502
G+ + + E+G+L I + K D G YTC+ATN G A + L VKDPTR+
Sbjct: 478 NGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR 537
Query: 503 PPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLM 562
P G ++ L C+V HD SL + +W + D R+ +D + L
Sbjct: 538 MPEDQVARRGTTVQLECRVKHDPSLKLTVSW------LKDDEPLYIGNRMKKEDDS--LT 589
Query: 563 IRNIQLKHAGKYVCMVQTSVDRLSAAADLIV---------------RGPPGPPEAVTIDE 607
I + + G Y C+ T +D+ A A L V +G P P + + +
Sbjct: 590 IFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTD 649
Query: 608 ITDTTAQLSWRPGPDNHSPITMYVIQ-ARTPFSVG-WQAVSTVPELIDGKTFTATVVGLN 665
+ + + +L+W PG N+SPIT YV+Q F G W S P ++ + V+ L+
Sbjct: 650 LAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN-----SAVLRLS 704
Query: 666 PWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPE 725
P+V Y+FR +A N +G PS PSE+ RT A PE P +V G G K+ + ITW +
Sbjct: 705 PYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNA 764
Query: 726 ELQNGRGFGYVVAF-RPYGKMIW-MLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNK 783
G Y+V + R + W +TV SRYV V + P+E++V N+
Sbjct: 765 TSAFGPNLRYIVKWRRRETREAWNNVTVW----GSRYVVGQTPV--YVPYEIRVQAENDF 818
Query: 784 GEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKN-RGRIQGYEVKYWR 842
G+GP + + YS E+ P P + R +++T I + W +G+++ Y YWR
Sbjct: 819 GKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWR 878
Query: 843 HEDKEEN------ARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTT 896
+N ++ G++ ++ L Y L + N G GP S T TT
Sbjct: 879 ESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTT 938
Query: 897 RKPPPSQPPGNIIWNSSDSKIILNWD 922
+ PS P + + I L WD
Sbjct: 939 PEGVPSAPRRFRVRQPNLETINLEWD 964
>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
[Homo sapiens]
Length = 1224
Score = 356 bits (913), Expect = 7e-98
Identities = 267/962 (27%), Positives = 414/962 (43%), Gaps = 75/962 (7%)
Query: 27 IFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLI 86
I Q V FP D + ++ CE KGNP+P W +G D R S
Sbjct: 37 IIKQSKVQVAFPFD---EYFQIECEAKGNPEPTFSWTKDGNPFYF-TDHRIIPSNNSGTF 92
Query: 87 NNPNK---TQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLL 143
PN+ + G Y+C A+N G +S E + + F + V G +VL
Sbjct: 93 RIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLP 152
Query: 144 CGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGN-YTCVVTNTVTN 202
C PP L W+ E + + R + G+LY A VE+ D N Y C
Sbjct: 153 CNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLR 212
Query: 203 HKVLGPPTPLILR-----ND-----------GVMGEYEPKI-----EVQFPETVPTAKGA 241
V P L + ND + + +PK+ E ++ KG
Sbjct: 213 TIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGE 272
Query: 242 TVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSR 301
+ LECFA G P P + W + G + + L+I N +D G Y C A N
Sbjct: 273 ILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFL 332
Query: 302 GKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDR 361
G + P W +K + N C+A G P+PT KW NG P+
Sbjct: 333 GTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPF 392
Query: 362 IQIEQGTLNITIVNL--SDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLV 419
I+ NL + +YQC A N HG I +NA + V+ V P + V
Sbjct: 393 AGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATV 452
Query: 420 KVGGEVVIECKPKASPKPVYTWKKGRDILK-ENERITISEDGNLRIINVTKSDAGSYTCI 478
VG + C+ ASP+ V +W+K ++ E R I E+G L+I T+ DAGSY+C
Sbjct: 453 -VGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCW 511
Query: 479 ATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSL--DIVFTWSFN 536
N G + T NL +++ T++ V P + + + L C+ D L + +WS
Sbjct: 512 VENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWS-- 569
Query: 537 GHLIDFDRDGDHFERVGGQD-----SAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADL 591
+DG+ FE G +D +L I N+ L+ G Y C T++D + +
Sbjct: 570 -------KDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQV 622
Query: 592 IVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPEL 651
V P PPE + + E + + +L+W G D++S I+ Y+++ F + EL
Sbjct: 623 TVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVE----FEGNKEEPGRWEEL 678
Query: 652 --IDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGG 709
+ GK T ++ L P+V Y+FR +A N +G +PS+PS+ T A P+ P N+
Sbjct: 679 TRVQGKK-TTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQ 737
Query: 710 GGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMI-WMLTVLASADASRYVFRNESVH 768
E++I WE + QNG G Y V ++P G + W + + R +
Sbjct: 738 ASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEW-----EEETVTNHTLRVMTPA 792
Query: 769 PFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWAS-PLE 827
++P++VKV N G GP + +YS E+ P P +++T ++V W++ P +
Sbjct: 793 VYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKD 852
Query: 828 KNRGRIQGYEVKYW--------RHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKA 879
+ GR++GY++ +W R KE N +R G + S + +L +HL V A
Sbjct: 853 RVHGRLKGYQINWWKTKSLLDGRTHPKEVNI--LRFSGQRNSGMVPSLDAFSEFHLTVLA 910
Query: 880 YNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVL 939
YNS G GP S T + P QP + L+W K L+ + GY +
Sbjct: 911 YNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLN--GNLTGYLLQ 968
Query: 940 YR 941
Y+
Sbjct: 969 YQ 970
>gi|81158226 neuronal cell adhesion molecule isoform A precursor
[Homo sapiens]
Length = 1304
Score = 352 bits (904), Expect = 8e-97
Identities = 277/954 (29%), Positives = 423/954 (44%), Gaps = 82/954 (8%)
Query: 26 PIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGS-- 83
P I + SP + +D E V + CE KG P P W NGT D D ++ G+
Sbjct: 45 PPTITQQSPKDYIIDPRENIV-IQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGT 103
Query: 84 LLIN--NPNKTQD-AGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGM 140
L+IN + K + G YQCTA N G VS ++ + + ++++ GQ +
Sbjct: 104 LIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSL 163
Query: 141 VLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVG-NYTCVV--- 196
VL C PP W+ N + + R G+LY + V D +Y C
Sbjct: 164 VLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFN 223
Query: 197 -TNTVTNHKVLGPPTPLILR-NDGVMGE------YEPKIEVQFPETVPTA---------- 238
T T+ + + + ND + Y K + P T T
Sbjct: 224 HTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEEL 283
Query: 239 KGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAE 298
+G + LEC A G P P I W + DG + L+I + + D+G Y+C+A+
Sbjct: 284 RGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAK 343
Query: 299 NSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPL-L 357
N+ G + A P WI ++ ++ E+ C+ANG PKP WL NG P+ +
Sbjct: 344 NALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEI 403
Query: 358 TRD--RIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKR 415
D +I+ T+ + V + +YQC A N++G + +NA ++V+A P R L
Sbjct: 404 APDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPP---RILTPA 460
Query: 416 VTLVKV--GGEVVIECKPKASPKPVYTWKKGRDILKENERI-TISEDGNLRIINVTKSDA 472
TL +V +++C SP P W KG +E I + E+G L I K
Sbjct: 461 NTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDST 520
Query: 473 GSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFT 532
G+YTC+A N G A + +L +KDPT ++ P V G + C+V HDH+L +
Sbjct: 521 GTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVL 580
Query: 533 WSFNGHLIDFDR----DGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAA 588
W + + D D DH L++ ++ +G Y C+ T++D +SA+
Sbjct: 581 WLKDNRELPSDERFTVDKDH------------LVVADVSDDDSGTYTCVANTTLDSVSAS 628
Query: 589 ADLIVRGP----------PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPF 638
A L V P P PP + + + D + QLSW PG DN+SPIT ++I+
Sbjct: 629 AVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAM 688
Query: 639 SVG--WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEE 696
W + V T T + L+P+V Y FR +A N IG PS SE+ T+
Sbjct: 689 HKPGLWHHQTEV-----SGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKA 743
Query: 697 ALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPY-GKMIWMLTVLASA 755
+ P+ P V G G LVITW+ + NG G Y V++R G W T + A
Sbjct: 744 SEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEW--TSVVVA 801
Query: 756 DASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSA 815
+ S+Y+ F P+ +KV N+ G P + +S E+ P P ++ +++
Sbjct: 802 NVSKYIV--SGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNS 859
Query: 816 TDIEVFW-ASPLEKNRGRIQGYEVKYWRHEDKEENAR-----KIRTV-GNQTSTKITNLK 868
T EV W PL+ RG +QGY + YW+ + + R KI T G++T + L+
Sbjct: 860 TLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLE 919
Query: 869 GSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWD 922
Y L V+ N G GP+S T + PS P I N + + L WD
Sbjct: 920 PFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWD 973
Score = 145 bits (367), Expect = 1e-34
Identities = 197/794 (24%), Positives = 308/794 (38%), Gaps = 107/794 (13%)
Query: 168 NRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKI 227
NR L I V ++D GNY C+ N + I V + P
Sbjct: 314 NRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALG----------AIHHTISVRVKAAP-Y 362
Query: 228 EVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPI--ARKARRHKSNG-ILEIPN 284
+ P+ + + G L C A GNP P I W +G PI A K +G + N
Sbjct: 363 WITAPQNLVLSPGEDGTLICRANGNPKPRISWL-TNGVPIEIAPDDPSRKIDGDTIIFSN 421
Query: 285 FQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWI-QKINDIH-VAMEENVFWECKANGR 342
Q+ + +Y+C A N G +A + A+P I N ++ V +C G
Sbjct: 422 VQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGS 481
Query: 343 PKPTYKWLKNGEPLLTRDRIQI--EQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELS 400
P PT +W K + + I + E GTL I + G Y C+A NK G+ + L
Sbjct: 482 PLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLE 541
Query: 401 V-----IAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYT--WKKGRDILKENER 453
+ I P+++ +V+ G V ECK K T W K L +ER
Sbjct: 542 IKDPTWIVKQPEYA--------VVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDER 593
Query: 454 ITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTR-------VMVPPSS 506
T+ +D +L + +V+ D+G+YTC+A + S++ L V PT V PP
Sbjct: 594 FTVDKD-HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFD 652
Query: 507 MDVT--VGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFD----RDG--DHFERVGGQDSA 558
+++T + +S+ L D++ I +I+++ + G H V G +
Sbjct: 653 LELTDQLDKSVQLSWTPGDDNNSPIT------KFIIEYEDAMHKPGLWHHQTEVSGTQTT 706
Query: 559 GDLMI--------RNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITD 610
L + R + + GK + + S L+ A++ P P AV
Sbjct: 707 AQLKLSPYVNYSFRVMAVNSIGKSLPS-EASEQYLTKASE-----PDKNPTAVEGLGSEP 760
Query: 611 TTAQLSWRP--GPDNHSPITMYVIQARTPFSVG-WQAVSTVPELIDGKTFTATVVGLNPW 667
++W+P G +++ P Y + R W +V + V G +
Sbjct: 761 DNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSV------VVANVSKYIVSGTPTF 814
Query: 668 VEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEEL 727
V Y + A N +G P + E LP V P NV + + + W+ VP +
Sbjct: 815 VPYLIKVQALNDMGFA-PEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKS 873
Query: 728 QNGRGFGYVVAFRPYGKMIWMLTVLASADASRYV------FRNESVH-------PFSPFE 774
G GY ++ + T +S R++ F+ H PFS +
Sbjct: 874 IRGHLQGY--------RIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYT 925
Query: 775 VKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPA-SIFARSLSATDIEVFWASPLEKNRGRI 833
+ V V N KGEGP SP V + E P+ P + I +L + +E W P N G +
Sbjct: 926 LNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLE--WDPPSHPN-GIL 982
Query: 834 QGYEVKYWRHEDKEENARKI--RTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSAT 891
Y +KY E + + N+T + NL S Y A SAG+G
Sbjct: 983 TEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITE 1042
Query: 892 VNVTTRKPPPSQPP 905
VTT PP
Sbjct: 1043 EAVTTVDEAGILPP 1056
Score = 55.1 bits (131), Expect = 3e-07
Identities = 45/183 (24%), Positives = 79/183 (43%), Gaps = 6/183 (3%)
Query: 769 PFSPFEVKVGVFNNKGEGPFSPTTVVYSAE-EEPTKPPASIFARSLSATDIEVFWASPLE 827
P+ + +V N+ G+ S + Y + EP K P ++ ++ + W PL
Sbjct: 713 PYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITW-KPLN 771
Query: 828 KNRGRIQGYEVKY-WRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTG 886
G + K WR +D ++ + V N + ++ V Y + V+A N G
Sbjct: 772 GFESNGPGLQYKVSWRQKDGDDEWTSV-VVANVSKYIVSGTPTFVPYLIKVQALNDMGFA 830
Query: 887 PSSATVNVTTRKPPPSQPPGNIIWNSSDSKII-LNWDQVKALDNESEVKGYKVLYRWNRQ 945
P A V + + P PGN+ N +S + ++WD V ++GY++ Y W Q
Sbjct: 831 PEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYY-WKTQ 889
Query: 946 SST 948
SS+
Sbjct: 890 SSS 892
>gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]
Length = 1240
Score = 339 bits (870), Expect = 7e-93
Identities = 263/905 (29%), Positives = 400/905 (44%), Gaps = 68/905 (7%)
Query: 46 VKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVE--GSLLIN---NPNKTQDAGTYQC 100
+ + CE KGNP P W N + D R S+ G+L+I+ + G YQC
Sbjct: 59 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQC 118
Query: 101 TATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFN 160
A N FGT +S +LQ + + V V+ G + L C PPP W+ +
Sbjct: 119 FARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSS 178
Query: 161 EYPSYQDNRRFVSQETGNLYIAKVEKSDVG-NYTCVVTNTVTNHKVLGPPTPLILRNDGV 219
++R G+LY + V D+ +Y+C T+ + P L+
Sbjct: 179 SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTH--TIQQKNPFTLKVLTT 236
Query: 220 MGEYEPKIEVQFPETVPTA----KGATVKLECFALGNPVPTIIWRRADGKPIARKARRHK 275
G E +P+ ++ +G + LEC A G P P I W + G + KA+
Sbjct: 237 RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFEN 296
Query: 276 SNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFW 335
N L I N +ED+G Y C+A N G + A P W+ + ++ +A E+
Sbjct: 297 FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRL 356
Query: 336 ECKANGRPKPTYKWLKNGEPLLT---RDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGV 392
C+ANG PKPT +W+ NGEPL + ++ T+ +S +YQC N+HG
Sbjct: 357 VCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGY 416
Query: 393 IFSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTW-KKGRDILK 449
+ +NA +SV+ V P R L R L++V ++C SP P W K G+
Sbjct: 417 LLANAFVSVLDVPP---RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL 473
Query: 450 ENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDV 509
+ + E+G+L I + K D G YTC+ATN G A + L VKDPTR+ P
Sbjct: 474 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVA 533
Query: 510 TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK 569
G ++ L C+V HD SL + +W + D R+ +D + L I + +
Sbjct: 534 RRGTTVQLECRVKHDPSLKLTVSW------LKDDEPLYIGNRMKKEDDS--LTIFGVAER 585
Query: 570 HAGKYVCMVQTSVDRLSAAADLIV---------------RGPPGPPEAVTIDEITDTTAQ 614
G Y C+ T +D+ A A L V +G P P + + ++ + + +
Sbjct: 586 DQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVR 645
Query: 615 LSWRPGPDNHSPITMYVIQ-ARTPFSVG-WQAVSTVPELIDGKTFTATVVGLNPWVEYEF 672
L+W PG N+SPIT YV+Q F G W S P ++ + V+ L+P+V Y+F
Sbjct: 646 LTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN-----SAVLRLSPYVNYQF 700
Query: 673 RTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRG 732
R +A N +G PS PSE+ RT A PE P +V G G K+ + ITW + G
Sbjct: 701 RVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPN 760
Query: 733 FGYVVAF-RPYGKMIW-MLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSP 790
Y+V + R + W +TV SRYV V + P+E++V N+ G+GP
Sbjct: 761 LRYIVKWRRRETREAWNNVTVW----GSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPE 814
Query: 791 TTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENA 850
+ + YS E+ P+ P R + I + W P E G + GY +KY +
Sbjct: 815 SVIGYSGEDLPS-APRRFRVRQPNLETINLEWDHP-EHPNGIMIGYTLKYVAFNGTKVGK 872
Query: 851 RKIRTVG-NQTSTKITNLKGSVLYHLAVKAYNSAGTG-----PSSATVN-VTTRKPPPSQ 903
+ + NQT + Y + A G+G S A N T PP+
Sbjct: 873 QIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAPPTL 932
Query: 904 PPGNI 908
PP +
Sbjct: 933 PPTTV 937
Score = 80.5 bits (197), Expect = 8e-15
Identities = 166/742 (22%), Positives = 264/742 (35%), Gaps = 95/742 (12%)
Query: 233 ETVPTAKGATVKLECFAL-GNPVPTIIWRRADGKPIARKARRHKS-NGILEIPNFQQEDA 290
+ V +GA + L+C G P P I W + +PI + R + NG L N +D
Sbjct: 148 DPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDM 207
Query: 291 GL-YECVAE-----NSRGKN-------VARG---QLTFYAQPNWIQKINDIHVAMEENVF 334
Y C A + KN RG + + P + M+ +
Sbjct: 208 QTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMD--LL 265
Query: 335 WECKANGRPKPTYKWLKNGEPLLTRDRIQIEQ--GTLNITIVNLSDAGMYQCLAENKHGV 392
EC A+G P P W K G L + D+ + E L IT V+ D+G Y CLA NK G
Sbjct: 266 LECIASGVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGS 324
Query: 393 IFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWK-KGRDILKEN 451
I + V A + ++ G + + C+ +PKP W G +
Sbjct: 325 IRHTISVRVKAAPYWLDEP---KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAP 381
Query: 452 ERITISEDGNLRIINVTK-SDAGSYTCIATNHFGTASSTGNLVVKD-PTRVMVPPSSM-D 508
G+ I T+ S Y C +N G + + V D P R++ P + +
Sbjct: 382 PNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIR 441
Query: 509 VTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQL 568
V + L C S W NG + D H G L I+ I+
Sbjct: 442 VILYNRTRLDCPFFG--SPIPTLRWFKNGQGSNLDGGNYHVYE------NGSLEIKMIRK 493
Query: 569 KHAGKYVCMVQTSVDRLSAAADLIVRGPPG---PPEAVTIDEIT--DTTAQLSWRPGPDN 623
+ G Y C+ + + L V+ P PE D++ TT QL R D
Sbjct: 494 EDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE----DQVARRGTTVQLECRVKHDP 549
Query: 624 HSPITMYVIQARTPFSVGWQ--------AVSTVPELIDGKTFTATVVGLNPWVEYEFRTV 675
+T+ ++ P +G + + V E G L+ + + TV
Sbjct: 550 SLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
Query: 676 AAN---------VIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEE 726
A+ + G P RP + T+ A V +TW +P +
Sbjct: 610 LADQATPTNRLAALPKGRPDRPRDLELTDLAERSVR---------------LTW--IPGD 652
Query: 727 LQNGRGFGYVVAFRP--YGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKG 784
N YVV F + +W + V R + P+ ++ +V N G
Sbjct: 653 ANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLR---LSPYVNYQFRVIAINEVG 709
Query: 785 EG-PFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKY--- 840
P P+ ++ P P + ++E+ W +P+ N G ++Y
Sbjct: 710 SSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITW-TPM--NATSAFGPNLRYIVK 766
Query: 841 WRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPP 900
WR + E + G++ T + V Y + V+A N G GP +V + +
Sbjct: 767 WRRRETREAWNNVTVWGSRYVVGQTPVY--VPYEIRVQAENDFGKGPEPESVIGYSGEDL 824
Query: 901 PSQPPGNIIWNSSDSKIILNWD 922
PS P + + I L WD
Sbjct: 825 PSAPRRFRVRQPNLETINLEWD 846
Score = 70.9 bits (172), Expect = 6e-12
Identities = 73/307 (23%), Positives = 120/307 (39%), Gaps = 44/307 (14%)
Query: 320 QKINDIHVAMEENVFWECKANGRPKPTYKWLKNGE--PLLTRDRIQIEQGTLNITIVNLS 377
Q D V +N+ EC+A G P P++ W +N + R+ + + + + I S
Sbjct: 46 QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105
Query: 378 DA------GMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKP 431
G YQC A NK G SN ++ P + + L V +V+ G + ++C P
Sbjct: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV-VVQEGAPLTLQCNP 164
Query: 432 KAS-PKPVYTW-KKGRDILKENERITISEDGNLRIINVTKSDAGS-YTCIATNHF----- 483
P PV W + + +++R++ +G+L NV D + Y+C A HF
Sbjct: 165 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 224
Query: 484 -------------GTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIV 530
G A T + + T SS V G ++L C + + DI
Sbjct: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGT-----ASSQMVLRGMDLLLECIASGVPTPDI- 278
Query: 531 FTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAAD 590
W G D D FE L I N+ + +G+Y C+ + +
Sbjct: 279 -AWYKKGG--DLPSDKAKFENFNKA-----LRITNVSEEDSGEYFCLASNKMGSIRHTIS 330
Query: 591 LIVRGPP 597
+ V+ P
Sbjct: 331 VRVKAAP 337
Score = 58.5 bits (140), Expect = 3e-08
Identities = 48/157 (30%), Positives = 75/157 (47%), Gaps = 12/157 (7%)
Query: 45 KVKLNCEVKGNPKPHIRWKLN--GTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTA 102
+ +L+C G+P P +RW N G+++D G Y V E L + +D G Y C A
Sbjct: 447 RTRLDCPFFGSPIPTLRWFKNGQGSNLDGG---NYHVYENGSLEIKMIRKEDQGIYTCVA 503
Query: 103 TNSFGTIVSREAKLQFAYLDNFKT-RTRSTVSVRRGQGMVLLCG-PPPHSGELSYAWIFN 160
TN G E +++ D + R RRG + L C S +L+ +W+ +
Sbjct: 504 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560
Query: 161 EYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVT 197
+ P Y NR + +E +L I V + D G+YTCV +
Sbjct: 561 DEPLYIGNR--MKKEDDSLTIFGVAERDQGSYTCVAS 595
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 310 bits (794), Expect = 4e-84
Identities = 274/1010 (27%), Positives = 436/1010 (43%), Gaps = 62/1010 (6%)
Query: 3 LPWELLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRW 62
L W LL L A D P F EP V + E ++ L C +G+ +W
Sbjct: 5 LIWTLLALHQIRAARAQDDV--SPYFKTEP--VRTQVHLEGNRLVLTCMAEGSWPLEFKW 60
Query: 63 KLNGTDVDT-GMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYL 121
N ++ +++RY +I + ++T AG Y+C N G ++ R+ ++Q AY+
Sbjct: 61 LHNNRELTKFSLEYRY-------MITSLDRTH-AGFYRCIVRNRMGALLQRQTEVQVAYM 112
Query: 122 DNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYI 181
+F+ + SV G+ V+ + W F + + R L I
Sbjct: 113 GSFEEGEKHQ-SVSHGEAAVIRAPRIASFPQPQVTW-FRDGRKIPPSSRIAITLENTLVI 170
Query: 182 AKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGE-YEPKIEVQFPETVPTAKG 240
D G Y N P L + N G + P I + T A
Sbjct: 171 LSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGT 230
Query: 241 ATVKLECFALGNPVPT--IIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYEC--V 296
+ V LEC A P+ IIW++ DG ++ H N L IPN DAG YEC V
Sbjct: 231 SEVTLECVANARPLIKLHIIWKK-DGVLLSGGISDH--NRRLTIPNPTGSDAGYYECEAV 287
Query: 297 AENSRGKNVARGQLTFYAQPNWIQKINDIHVA--MEENVFWECKANGRPKPTYKWLKNGE 354
+S +V RG +P K + H+ ME+ V C+A G P P+ W K+
Sbjct: 288 LRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAA 347
Query: 355 PL----LTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSR 410
+ LTR R Q G L I+ + D GM+QC A N G + ++ L+V ++ P+ +R
Sbjct: 348 VVEVEKLTRFR-QRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITR 406
Query: 411 TLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENE----RITISEDGNLRIIN 466
L + G VV+ C+ +P+P TW+KG IL R T E G+L I
Sbjct: 407 GPLDSTVID--GMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISP 464
Query: 467 VTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHS 526
SDAG+YTC+ATN G ++ +LVV TR+ PP V G + C VTHD
Sbjct: 465 THISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPR 524
Query: 527 LDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLS 586
+ I + W +G + G D G L I G Y C V ++ S
Sbjct: 525 VTIRYIWEKDGATL-----GTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDS 579
Query: 587 AAADLIVRGPPGPPE--AVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQA 644
+A L VR P PE T+ + L+W D +SP+ Y+++ + + W
Sbjct: 580 RSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILE-MSENNAPW-- 636
Query: 645 VSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPA 704
+ + +D K + TV GL P Y+FR A N +G G+ S+ +E+ E P P
Sbjct: 637 -TVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQ 695
Query: 705 NVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMI-WMLTVLASADASRYVFR 763
NV G + ++I W+ PE QNG GY++ + G + + + AD + +
Sbjct: 696 NVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLL- 754
Query: 764 NESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWA 823
E + ++ +E++V +N+ G G +S ++ + PT PP ++ A + ++T I W
Sbjct: 755 -EDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWN 813
Query: 824 SPLEK-NRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTK---ITNLKGSVLYHLAVKA 879
+P + G QGY++ W E +EE Q S ++ LK Y +V
Sbjct: 814 APSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLC 873
Query: 880 YNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNS-SDSKIILNWDQVKALDNESEVKGYKV 938
+ + G GP S V T + P P G++ ++ D+ + ++W + + + GY++
Sbjct: 874 FTTPGDGPRSTPQLVRTHEDVPG-PVGHLSFSEILDTSLKVSWQEPG--EKNGILTGYRI 930
Query: 939 LY-RWNRQSSTSVIETNKTSVE---LSLPFDEDYIIEIKPFSDGGDGSSS 984
+ +NR ++ ++E L Y IE+ + G G S
Sbjct: 931 SWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVS 980
Score = 141 bits (356), Expect = 3e-33
Identities = 106/381 (27%), Positives = 171/381 (44%), Gaps = 32/381 (8%)
Query: 587 AAADLIV----RGPPGPPEAVTI--DEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSV 640
AA L+V R P PP + +++ + LSW PG D SP+ Y IQ R S
Sbjct: 1386 AAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSG 1445
Query: 641 GWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPE 700
W S + + V L P+ Y+FR A N IG E S SE T +A P+
Sbjct: 1446 RWALHSAS---VSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPD 1502
Query: 701 VTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPY---GKMIWMLTVLASADA 757
P +S + + ++I W+ E+ NG G+ + +R G + L + + A
Sbjct: 1503 EAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGA 1562
Query: 758 ------SRYVFRN-----------ESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEE 800
S Y RN ++++ +E+++ V+N GEGP SP V+ E
Sbjct: 1563 TWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAV 1622
Query: 801 PTKPPASIFARSLSATDIEVFW-ASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQ 859
PT P ++ +AT ++V W PL+ G IQGY++ +W + R +
Sbjct: 1623 PTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAE 1682
Query: 860 TSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIIL 919
S K+ NL G Y ++V A+N+AG GP S T++ PS P + + + +
Sbjct: 1683 NSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNV 1742
Query: 920 NWDQVKALDNESEVKGYKVLY 940
+W+ + + E GY+++Y
Sbjct: 1743 SWEAPQFPNGILE--GYRLVY 1761
Score = 130 bits (326), Expect = 8e-30
Identities = 108/384 (28%), Positives = 179/384 (46%), Gaps = 28/384 (7%)
Query: 597 PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVG----WQAVSTVPELI 652
PGPP + I I + L +RPG D + I+ ++++A+ VG W + +
Sbjct: 993 PGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGV-VGEGEEWLLIHQLSNEP 1051
Query: 653 DGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGS 712
D ++ V LNP+ Y FR N++G PS+PS K +T +A P++ PANVS S
Sbjct: 1052 DARSME--VPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTAS 1109
Query: 713 KSELVITWETVPEELQNG--RGFGYVVAFR---PYGKMIWMLTVLASADASRYVFRNESV 767
++ L + W +PE NG GY + + +GK + + D + E +
Sbjct: 1110 ETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVV----QDRVERDYTIEDL 1165
Query: 768 HPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLE 827
++ + V+V FN G GP+S T V + E P+ P ++ A + +++ + V W+ E
Sbjct: 1166 EEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPE 1225
Query: 828 KNR-GRIQGYEVKYWRHEDKEENARKIRTVGNQT-STKITNLKGSVLYHLAVKAYNSAGT 885
+R G + GY+V Y + +D + R GN + S ++T L VLY + V A+ G
Sbjct: 1226 ADRNGLVLGYKVMY-KEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGD 1284
Query: 886 G-PSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNR 944
G PS + T P P G + + + L W Q A N + Y++ +R N
Sbjct: 1285 GSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIW-QPPAAPN-GIILAYQITHRLNT 1342
Query: 945 QSSTSVIETNKTSVELSLPFDEDY 968
++ N +VE+ P Y
Sbjct: 1343 TTA------NTATVEVLAPSARQY 1360
Score = 101 bits (252), Expect = 3e-21
Identities = 98/404 (24%), Positives = 163/404 (40%), Gaps = 22/404 (5%)
Query: 596 PPGPPEAVTIDEITDTTAQLSWRPGPD---NHSPITM-YVIQARTPFSVGWQAVSTVPEL 651
P P V++ ++T+ L W P P+ N +P ++ Y I+ G V +
Sbjct: 1096 PDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDR 1155
Query: 652 IDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGG 711
++ T+ L W EY + A N IG G P + RT E++P P NVS
Sbjct: 1156 VERDY---TIEDLEEWTEYRVQVQAFNAIGSG-PWSQTVVGRTRESVPSSGPTNVSALAT 1211
Query: 712 SKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFS 771
+ S +++ W VPE +NG GY V ++ L ++SR + + +
Sbjct: 1212 TSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSA-QLTGLGKYV 1270
Query: 772 PFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRG 831
+EV+V F G+G S ++ ++ PP I + T + + W P N G
Sbjct: 1271 LYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPN-G 1329
Query: 832 RIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSAT 891
I Y++ + + A + T LK +Y + A G G ++
Sbjct: 1330 IILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEA 1389
Query: 892 VNVTTRKPPPSQPPGNIIWNSSDSK---IILNWDQVKALDNESEVKGYKVLY------RW 942
+ VTT K QPP + D + ++L+W+ D S V+ Y + RW
Sbjct: 1390 LVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE--PGSDGLSPVRYYTIQTRELPSGRW 1447
Query: 943 NRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQ 986
S++ + V+ PF Y +K +D GD SE+
Sbjct: 1448 ALHSASVSHNASSFIVDRLKPF-TSYKFRVKATNDIGDSEFSEE 1490
Score = 63.2 bits (152), Expect = 1e-09
Identities = 37/106 (34%), Positives = 51/106 (48%), Gaps = 4/106 (3%)
Query: 595 GPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQA-VSTVPELID 653
G PGPP I + A + W G PIT YVI+AR W + +P+ +
Sbjct: 1823 GAPGPPGVPIIVRYSSAIA-IHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVS 1881
Query: 654 GKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALP 699
TF+ + L P V Y+FR +A N G G PS PS+ ++A P
Sbjct: 1882 SYTFSMDI--LKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1925
Score = 61.2 bits (147), Expect = 5e-09
Identities = 90/450 (20%), Positives = 168/450 (37%), Gaps = 39/450 (8%)
Query: 596 PPGPPEAVTIDEITDTTAQLSWR-PGPDNHSPITM-YVIQARTPFSVGWQAVSTVPELID 653
P PP V + TT + +W P P + I Y + A P + T
Sbjct: 791 PTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQ 850
Query: 654 GKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSK 713
V GL + EY + G G S P + RT E +P ++S
Sbjct: 851 DSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTP-QLVRTHEDVPGPV-GHLSFSEILD 908
Query: 714 SELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPF 773
+ L ++W+ E+ NG GY +++ Y + +T Y R + + +
Sbjct: 909 TSLKVSWQEPGEK--NGILTGYRISWEEYNRTNTRVTHYLPNVTLEY--RVTGLTALTTY 964
Query: 774 EVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRI 833
++V +KG+G S +T+ E PP ++ ++ + L+ G
Sbjct: 965 TIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSV------TLQFRPGYD 1018
Query: 834 QGYEVKYWRHE------DKEENARKIRTVGNQ---TSTKITNLKGSVLYHLAVKAYNSAG 884
+ W E + E I + N+ S ++ +L Y ++ N G
Sbjct: 1019 GKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVG 1078
Query: 885 TG-PSSATVNVTTRKPPPSQPPGNI-IWNSSDSKIILNWDQVKALD--NESEVKGYKVLY 940
T PS + + T + PP P N+ + +S++ + L W + ++ E GYK+ Y
Sbjct: 1079 TSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKY 1138
Query: 941 RWNRQSSTSVIETNKTSVELSLPFDE-----DYIIEIKPFSDGGDGSSSEQIRIPKISNA 995
+ ++ + VE ++ +Y ++++ F+ G G S+ +
Sbjct: 1139 SRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTV-------V 1191
Query: 996 YARGSGASTSNACTLSAISTIMISLTARSS 1025
+S +SA++T S+ R S
Sbjct: 1192 GRTRESVPSSGPTNVSALATTSSSMLVRWS 1221
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 266 bits (681), Expect = 6e-71
Identities = 253/986 (25%), Positives = 408/986 (41%), Gaps = 65/986 (6%)
Query: 5 WELLVLQSFIL-CLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWK 63
W LL LQ +L LA D P F EP L E ++ L C +G+ +W
Sbjct: 84 WALLALQLHLLRALAQDDV--APYFKTEPGLPQIHL--EGNRLVLTCLAEGSWPLEFKWM 139
Query: 64 LNGTDVDT-GMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLD 122
+ +++ T +++Y + L DAG Y+C N G ++ R++++Q AY+
Sbjct: 140 RDDSELTTYSSEYKYIIPSLQKL--------DAGFYRCVVRNRMGALLQRKSEVQVAYMG 191
Query: 123 NFK-TRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYI 181
+F T R TVS +G+ +L P W + NR ++ E L I
Sbjct: 192 SFMDTDQRKTVS--QGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLEN-QLVI 248
Query: 182 AKVEKSDVGNYTCVVTNTVTNHKVLGPPTPL-ILRNDGVMGEYEPKIEVQFPETVPTAKG 240
SD G Y N P L I R+ G P I V A
Sbjct: 249 LATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGS 308
Query: 241 ATVKLECFALGNPVP--TIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAE 298
+ LEC A PV ++ W+R + + H L I N D G Y C A
Sbjct: 309 SETTLECIASARPVEDLSVTWKR---NGVRITSGLHSFGRRLTISNPTSADTGPYVCEAA 365
Query: 299 --NSRGKNVARGQLTFYAQPNWI--QKINDIHVAMEENVFWECKANGRPKPTYKWLKNGE 354
S + F +P + + + I +EE V C+A G P PT +W K+
Sbjct: 366 LPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAI 425
Query: 355 PL--LTRDRIQI-EQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRT 411
+ L R ++ G L I + D+G++QC A N+ G I ++ L V + P F++
Sbjct: 426 SISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQR 485
Query: 412 LLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENE----RITISEDGNLRIINV 467
+ T V G ++ C+ +PKP TWK+ IL R + E G L+I V
Sbjct: 486 PVD--TTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPV 543
Query: 468 TKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSL 527
DAG+YTC A N G+ +++ L V + T ++ PP V G + L C THD +
Sbjct: 544 FIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRV 603
Query: 528 DIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSA 587
+ + W + + R+ + G L+I G Y C + + S
Sbjct: 604 SLRYVWKKDNVAL----TPSSTSRI-VVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSR 658
Query: 588 AADLIVRGPPGPPEAVTIDEITDTT--AQLSWRPGPDNHSPITMYVIQA---RTPFSVGW 642
A L V P P+ + + + + LSW D +SPI Y+++ +P+ V
Sbjct: 659 MARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHL 718
Query: 643 QAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVT 702
V PE+ TV GL P Y+FR A N +G G+ S + + E P
Sbjct: 719 SNVG--PEMTG-----VTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAP 771
Query: 703 PANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVF 762
P N+ G + +++ W+ PE NG GY++ +R G ++ Y
Sbjct: 772 PKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCL 831
Query: 763 RNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFW 822
+ + ++ +E++V +N G G FS Y+ + PT PP ++ ++++T I+ W
Sbjct: 832 VTDLI-IWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLW 890
Query: 823 ASPLEK-NRGRIQGYEVKYWRHEDKEENARKIRTVG----NQTSTKITNLKGSVLYHLAV 877
P ++ G QGY++ W + E A + T+ ITNLK Y +V
Sbjct: 891 NPPPQQFINGINQGYKLLAWPADAPE--AVTVVTIAPDFHGVHHGHITNLKKFTAYFTSV 948
Query: 878 KAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYK 937
+ + G GP S V T++ P D+ + ++W + L+ + GY+
Sbjct: 949 LCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQE--PLEKNGIITGYQ 1006
Query: 938 VLYR-WNRQSSTSVIETNKTSVELSL 962
+ + + R S N T+ E +
Sbjct: 1007 ISWEVYGRNDSRLTHTLNSTTHEYKI 1032
Score = 165 bits (417), Expect = 2e-40
Identities = 192/748 (25%), Positives = 305/748 (40%), Gaps = 91/748 (12%)
Query: 224 EPKIEVQFPETVPTAK-GATVKLECFALGNPVPTIIWRRADGKPIARKAR-RHK--SNGI 279
EP PE+ +A+ TV + C A+G P+PT+ W + D I+R R+K ++G
Sbjct: 384 EPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYK-DAISISRLQNPRYKVLASGG 442
Query: 280 LEIPNFQQEDAGLYECVAENSRGKNVARGQLTFY-AQPNWIQKINDIHVAMEENVFWECK 338
L I + ED+G+++C A N G+ L P + Q+ D V C+
Sbjct: 443 LRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCE 502
Query: 339 ANGRPKPTYKWLKNGEPLLTRDRIQI------EQGTLNITIVNLSDAGMYQCLAENKHGV 392
+G PKP W K +L ++I E G L I V + DAG Y C A N G
Sbjct: 503 VSGAPKPAITW-KRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGS 561
Query: 393 IFSNAELSV----IAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPV--YTWKKGRD 446
+ ++A L+V V P ++K T + C P+ Y WKK
Sbjct: 562 LNASATLTVWNRTSIVHPPEDHVVIKGTT-------ATLHCGATHDPRVSLRYVWKKDNV 614
Query: 447 IL--KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD----PTRV 500
L RI + +DG+L I D G Y+C + G S L V + P +
Sbjct: 615 ALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNL 674
Query: 501 MVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNG------HLIDFDRDGD----HFE 550
+V P+S +H H++ + + F+G ++++ + H
Sbjct: 675 LVSPNS---------------SHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLS 719
Query: 551 RVG----GQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAAD-----LIVRGPPGPPE 601
VG G +G R Q + VC V V R +A+ L P PP+
Sbjct: 720 NVGPEMTGVTVSGLTPARTYQFR-----VCAVN-EVGRGQYSAETSRLMLPEEPPSAPPK 773
Query: 602 AVTIDEITDTTAQLSWRPGPD--NHSPITMYVIQARTPFSVG--WQAVSTVPELIDGKTF 657
+ T+ + + W+P P+ ++ + Y+++ R G Q T PE+
Sbjct: 774 NIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVN----- 828
Query: 658 TATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELV 717
V L W +YE + A N G+G SR + T + +P P NV + + +
Sbjct: 829 YCLVTDLIIWTQYEIQVAAYNGAGLGVFSR-AVTEYTLQGVPTAPPQNVQTEAVNSTTIQ 887
Query: 718 ITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNE--SVHPFSPFEV 775
W P++ NG GY + P +TV+ A V ++ F+ +
Sbjct: 888 FLWNPPPQQFINGINQGYKLLAWP-ADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFT 946
Query: 776 KVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQG 835
V F G+GP S +V++ E++P F L T ++V W PLEKN G I G
Sbjct: 947 SVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILD-TSLKVSWQEPLEKN-GIITG 1004
Query: 836 YEVKYWRHEDKEENARKIRTVGNQTST-KITNLKGSVLYHLAVKAYNSAGTG-PSSATVN 893
Y++ W + ++ R T+ + T KI L Y + V A + GTG +S+T++
Sbjct: 1005 YQIS-WEVYGRNDS-RLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTIS 1062
Query: 894 VTTRKPPPSQPPGNIIWNSSDSKIILNW 921
P P +I N S L +
Sbjct: 1063 SGVPPDLPGAPSNLVISNISPRSATLQF 1090
Score = 122 bits (305), Expect = 2e-27
Identities = 95/371 (25%), Positives = 157/371 (42%), Gaps = 29/371 (7%)
Query: 594 RGPPGPPEAVTID--EITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPEL 651
R P PP + + E+T + +L W PG D SPI + +Q R WQ S+
Sbjct: 1474 RERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSS--- 1530
Query: 652 IDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGG 711
I + V L P+ Y+ R A N IG + S +E T + +P P +VS
Sbjct: 1531 ISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPH 1590
Query: 712 SKSELVITWETVPEELQNGRGFGYVVAFRPYG------------KMIWMLTVLASADASR 759
+ S ++I W+ +E NG GY + +R K L +A +S
Sbjct: 1591 TTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSF 1650
Query: 760 YVFRNES---------VHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFA 810
+ S + + +EV + +N GE P S V+ E P P ++
Sbjct: 1651 KTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQV 1710
Query: 811 RSLSATDIEVFW-ASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKG 869
L+A+ +EV W P E G IQGY++ YW + + E + + ++ NL
Sbjct: 1711 TPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTS 1770
Query: 870 SVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDN 929
Y +++ A+N+AG GP S T + P P + + + ++W + A +
Sbjct: 1771 HTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAAN- 1829
Query: 930 ESEVKGYKVLY 940
++GY+V+Y
Sbjct: 1830 -GILQGYRVVY 1839
Score = 114 bits (285), Expect = 5e-25
Identities = 104/434 (23%), Positives = 175/434 (40%), Gaps = 27/434 (6%)
Query: 596 PPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGK 655
P P +VT+ ++T+ +L W P PD+ + R + S V +++ +
Sbjct: 1173 PDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDR 1232
Query: 656 TFTA-TVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKS 714
T+ L W+EYE + A N +G G P + RT E++P P NVS S +
Sbjct: 1233 LEREFTIEELEEWMEYELQMQAFNAVGAG-PWSEVVRGRTRESVPSAAPENVSAEAVSST 1291
Query: 715 ELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNES-------V 767
++++TW +VPE+ QNG GY + FR L S V N + +
Sbjct: 1292 QILLTWTSVPEQDQNGLILGYKILFRAKD--------LDPEPRSHIVRGNHTQSALLAGL 1343
Query: 768 HPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLE 827
F +E++V F G G S ++ +++ PP + + T + + W P E
Sbjct: 1344 RKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEE 1403
Query: 828 KNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTG- 886
N G I GY++ Y + T+L Y + A G G
Sbjct: 1404 PN-GIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGE 1462
Query: 887 PSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYR----- 941
P ATV T ++ P+ P ++ + + L V D S ++ + + R
Sbjct: 1463 PLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRG 1522
Query: 942 -WNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGS-SSEQIRIPKISNAYARG 999
W SS+ E V+ PF Y + +K +D GD SSE + + +
Sbjct: 1523 EWQTYSSSISHEATACVVDRLRPF-TSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEP 1581
Query: 1000 SGASTSNACTLSAI 1013
G+ ++ T S++
Sbjct: 1582 PGSVSATPHTTSSV 1595
Score = 113 bits (283), Expect = 8e-25
Identities = 91/358 (25%), Positives = 161/358 (44%), Gaps = 24/358 (6%)
Query: 597 PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQA--VSTVPELIDG 654
PG P + I I+ +A L +RPG D + I+ ++++ + ++G + V+ E +
Sbjct: 1070 PGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVG-AIGDEEEWVTLYEEENEP 1128
Query: 655 KTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKS 714
+ L P+ Y FR N++G S S +T +A P+V P +V+ S++
Sbjct: 1129 DAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASET 1188
Query: 715 ELVITWETVPEELQNG--RGFGYVVAFRPYGKMIWMLTVLASA------DASRYVFRNES 766
L + W +P+ NG GY + + W + +SA D F E
Sbjct: 1189 SLRLRWVPLPDSQYNGNPESVGYRIKY-------WRSDLQSSAVAQVVSDRLEREFTIEE 1241
Query: 767 VHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWAS-P 825
+ + +E+++ FN G GP+S + E P+ P ++ A ++S+T I + W S P
Sbjct: 1242 LEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVP 1301
Query: 826 LEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQT-STKITNLKGSVLYHLAVKAYNSAG 884
+ G I GY++ + R +D + R GN T S + L+ VLY L V A+ G
Sbjct: 1302 EQDQNGLILGYKILF-RAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIG 1360
Query: 885 TG-PSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYR 941
G PS+ + T+ P P + + + + W + + + GY++ YR
Sbjct: 1361 NGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPE--EPNGIILGYQIAYR 1416
Score = 102 bits (254), Expect = 2e-21
Identities = 112/463 (24%), Positives = 188/463 (40%), Gaps = 59/463 (12%)
Query: 597 PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKT 656
PGPP + E+ T+ ++ W+P + + I Y I R S +TV +
Sbjct: 1378 PGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP-HTFTTVEVGATVRQ 1436
Query: 657 FTATVVGLNPWVEYEFRTVAANVIGIGEPSRPS---EKRRTEEALPE---VTPANVSGGG 710
FTAT L P Y FR A G GEP + ++R A P V A V+
Sbjct: 1437 FTAT--DLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTA-- 1492
Query: 711 GSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPF 770
L + W + R F V P G+ W T +S + + PF
Sbjct: 1493 ---RSLRLQWVPGSDGASPIRYFTMQVRELPRGE--WQ-TYSSSISHEATACVVDRLRPF 1546
Query: 771 SPFEVKVGVFNNKGEGPFSPTT-VVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKN 829
+ +++++ N+ G+ FS T V + ++ P +PP S+ A + + + + W P +++
Sbjct: 1547 TSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDES 1606
Query: 830 -RGRIQGYEVKYWRHEDKEENARKIRTVGN----------------------QTSTKITN 866
G +QGY + Y E + + + +T+ N T ++T+
Sbjct: 1607 LNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTH 1666
Query: 867 LKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNI-IWNSSDSKIILNWDQVK 925
LK Y + + AYN G P+SA V V + P+ P N+ + + S++ + WD
Sbjct: 1667 LKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPP 1726
Query: 926 ALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVEL---------SLPFDEDYIIEIKPFS 976
++GYK+ Y W S ET K V +L Y++ I F+
Sbjct: 1727 PESQNGNIQGYKIYY-WEADSQN---ETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFN 1782
Query: 977 DGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMIS 1019
GDG S+ P+ + GA + A + +T+ +S
Sbjct: 1783 AAGDGPKSD----PQQGRTHQAAPGAPSFLAFSEITSTTLNVS 1821
Score = 71.6 bits (174), Expect = 3e-12
Identities = 87/369 (23%), Positives = 142/369 (38%), Gaps = 63/369 (17%)
Query: 596 PPGPPEAVTIDEITDTTAQLSWRPGPDN-----------------------------HSP 626
P PP +V+ T ++ + W+P D +P
Sbjct: 1578 PGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNP 1637
Query: 627 ITMYV-IQARTPF-SVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGE 684
I ++ + A++ F +V + ST+ EL L + YE A N+IG
Sbjct: 1638 IALHAELTAQSSFKTVNSSSTSTMCEL----------THLKKYRRYEVIMTAYNIIGESP 1687
Query: 685 PSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGK 744
S P E EA P + P NV + S+L +TW+ P E QNG GY + +
Sbjct: 1688 ASAPVEV-FVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYY----- 1741
Query: 745 MIWMLTVLASADASRYVF------RNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAE 798
W + + +F R +++ + + V + FN G+GP S + +
Sbjct: 1742 --WEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQ 1799
Query: 799 EEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTV-- 856
P P F+ +++T + V W P N G +QGY V Y + K+ TV
Sbjct: 1800 AAPGAPSFLAFS-EITSTTLNVSWGEPAAAN-GILQGYRVVY-EPLAPVQGVSKVVTVEV 1856
Query: 857 -GN-QTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSD 914
GN Q K+ +L V Y V+A A + + P P +++ S
Sbjct: 1857 RGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGS-PRDVLVTKSA 1915
Query: 915 SKIILNWDQ 923
S++ L W +
Sbjct: 1916 SELTLQWTE 1924
Score = 54.7 bits (130), Expect = 4e-07
Identities = 35/96 (36%), Positives = 46/96 (47%), Gaps = 4/96 (4%)
Query: 595 GPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQA-VSTVPELID 653
G PG P V + + + + L W G +P T YVI+AR W V +P
Sbjct: 1901 GSPGSPRDVLVTK-SASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPR--S 1957
Query: 654 GKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPS 689
++T ++ L V YEFR VA N G GEPS PS
Sbjct: 1958 ATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPS 1993
Score = 42.7 bits (99), Expect = 0.002
Identities = 57/215 (26%), Positives = 77/215 (35%), Gaps = 23/215 (10%)
Query: 597 PGPPEAVTIDEITDTTAQLSW-RPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGK 655
PG P + EIT TT +SW P N V+ G V TV E+
Sbjct: 1802 PGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTV-EVRGNW 1860
Query: 656 TFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSE 715
V L V Y FR V A I G E +T G GS +
Sbjct: 1861 QRWLKVRDLTKGVTYFFR-VQARTITYG-----------PELQANITAGPAEGSPGSPRD 1908
Query: 716 LVITWETVPEELQNGRGF-------GYVVAFRPYGKMIW-MLTVLASADASRYVFRNESV 767
+++T LQ G GYV+ RP + +W M A+ Y + +
Sbjct: 1909 VLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKL 1968
Query: 768 HPFSPFEVKVGVFNNKGEG-PFSPTTVVYSAEEEP 801
+E +V N G G P +P+T V + E P
Sbjct: 1969 RQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
>gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]
Length = 613
Score = 234 bits (598), Expect = 2e-61
Identities = 176/614 (28%), Positives = 270/614 (43%), Gaps = 38/614 (6%)
Query: 4 PWELLVLQSFILCLAD-DSTLHGPIFIQEPSPVMFPLDSEE-----KKVKLNCEVKGNPK 57
PW V +F+LCL + P+ + +P + + + + CE KGNP
Sbjct: 8 PW---VHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPA 64
Query: 58 PHIRWKLNGTDVDTGMDFRYSVVE--GSLLIN---NPNKTQDAGTYQCTATNSFGTIVSR 112
P W N + D R S+ G+L+I+ + G YQC A N FGT +S
Sbjct: 65 PSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN 124
Query: 113 EAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFV 172
+LQ + + V V+ G + L C PPP W+ + ++R
Sbjct: 125 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVS 184
Query: 173 SQETGNLYIAKVEKSDVG-NYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQF 231
G+LY + V D+ +Y+C T+ + P L+ G E +
Sbjct: 185 QGHNGDLYFSNVMLQDMQTDYSCNARFHFTH--TIQQKNPFTLKVLTTRGVAERTPSFMY 242
Query: 232 PETVPTA----KGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQ 287
P+ ++ +G + LEC A G P P I W + G + KA+ N L I N +
Sbjct: 243 PQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSE 302
Query: 288 EDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTY 347
ED+G Y C+A N G + A P W+ + ++ +A E+ C+ANG PKPT
Sbjct: 303 EDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTV 362
Query: 348 KWLKNGEPLLT---RDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAV 404
+W+ NGEPL + ++ T+ +S +YQC N+HG + +NA +SV+ V
Sbjct: 363 QWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV 422
Query: 405 GPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTW-KKGRDILKENERITISEDGN 461
P R L R L++V ++C SP P W K G+ + + E+G+
Sbjct: 423 PP---RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS 479
Query: 462 LRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQV 521
L I + K D G YTC+ATN G A + L VKDPTR+ P G ++ L C+V
Sbjct: 480 LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRV 539
Query: 522 THDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTS 581
HD SL + +W + D R+ +D + L I + + G Y C+ T
Sbjct: 540 KHDPSLKLTVSW------LKDDEPLYIGNRMKKEDDS--LTIFGVAERDQGSYTCVASTE 591
Query: 582 VDRLSAAADLIVRG 595
+D+ A A L V G
Sbjct: 592 LDQDLAKAYLTVLG 605
Score = 88.6 bits (218), Expect = 3e-17
Identities = 101/373 (27%), Positives = 156/373 (41%), Gaps = 38/373 (10%)
Query: 48 LNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFG 107
L C G P P I W G D+ + ++ +L I N ++ +D+G Y C A+N G
Sbjct: 260 LECIASGVPTPDIAWYKKGGDLPSDKA-KFENFNKALRITNVSE-EDSGEYFCLASNKMG 317
Query: 108 TI---VSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLC----GPPPHSGELSYAWIFN 160
+I +S K +LD K + + G+ L+C P P + W+ N
Sbjct: 318 SIRHTISVRVKAAPYWLDEPKN-----LILAPGEDGRLVCRANGNPKP-----TVQWMVN 367
Query: 161 EYPSYQDNRRFVSQETGNLYIAK-VEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGV 219
P + G+ I + + S Y C NT H L L N V
Sbjct: 368 GEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQC---NTSNEHGYL-------LANAFV 417
Query: 220 -MGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIW-RRADGKPIARKARRHKSN 277
+ + P++ + + +L+C G+P+PT+ W + G + N
Sbjct: 418 SVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYEN 477
Query: 278 GILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQ-PNWIQKINDIHVAME-ENVFW 335
G LEI ++ED G+Y CVA N GK A Q+ + P I ++ + VA V
Sbjct: 478 GSLEIKMIRKEDQGIYTCVATNILGK--AENQVRLEVKDPTRIYRMPEDQVARRGTTVQL 535
Query: 336 ECKANGRP--KPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVI 393
EC+ P K T WLK+ EPL +R++ E +L I V D G Y C+A +
Sbjct: 536 ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQD 595
Query: 394 FSNAELSVIAVGP 406
+ A L+V+ P
Sbjct: 596 LAKAYLTVLGNCP 608
Score = 70.9 bits (172), Expect = 6e-12
Identities = 74/307 (24%), Positives = 122/307 (39%), Gaps = 44/307 (14%)
Query: 320 QKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPL-LTRD-RIQIEQGTLNITIVNLS 377
Q D V +N+ EC+A G P P++ W +N + +D R+ + + + + I S
Sbjct: 40 QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 99
Query: 378 DA------GMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKP 431
G YQC A NK G SN ++ P + + L V +V+ G + ++C P
Sbjct: 100 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV-VVQEGAPLTLQCNP 158
Query: 432 KAS-PKPVYTW-KKGRDILKENERITISEDGNLRIINVTKSDAGS-YTCIATNHF----- 483
P PV W + + +++R++ +G+L NV D + Y+C A HF
Sbjct: 159 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 218
Query: 484 -------------GTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIV 530
G A T + + T SS V G ++L C + + DI
Sbjct: 219 QKNPFTLKVLTTRGVAERTPSFMYPQGTA-----SSQMVLRGMDLLLECIASGVPTPDIA 273
Query: 531 FTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAAD 590
W G D D FE L I N+ + +G+Y C+ + +
Sbjct: 274 --WYKKGG--DLPSDKAKFENFNKA-----LRITNVSEEDSGEYFCLASNKMGSIRHTIS 324
Query: 591 LIVRGPP 597
+ V+ P
Sbjct: 325 VRVKAAP 331
>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
Length = 619
Score = 232 bits (592), Expect = 1e-60
Identities = 167/566 (29%), Positives = 253/566 (44%), Gaps = 29/566 (5%)
Query: 46 VKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVE--GSLLIN---NPNKTQDAGTYQC 100
+ + CE KGNP P W N + D R S+ G+L+I+ + G YQC
Sbjct: 59 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQC 118
Query: 101 TATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFN 160
A N FGT +S +LQ + + V V+ G + L C PPP W+ +
Sbjct: 119 FARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSS 178
Query: 161 EYPSYQDNRRFVSQETGNLYIAKVEKSDVG-NYTCVVTNTVTNHKVLGPPTPLILRNDGV 219
++R G+LY + V D+ +Y+C T+ + P L+
Sbjct: 179 SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTH--TIQQKNPFTLKVLTT 236
Query: 220 MGEYEPKIEVQFPETVPTA----KGATVKLECFALGNPVPTIIWRRADGKPIARKARRHK 275
G E +P+ ++ +G + LEC A G P P I W + G + KA+
Sbjct: 237 RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFEN 296
Query: 276 SNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFW 335
N L I N +ED+G Y C+A N G + A P W+ + ++ +A E+
Sbjct: 297 FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRL 356
Query: 336 ECKANGRPKPTYKWLKNGEPLLT---RDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGV 392
C+ANG PKPT +W+ NGEPL + ++ T+ +S +YQC N+HG
Sbjct: 357 VCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGY 416
Query: 393 IFSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTW-KKGRDILK 449
+ +NA +SV+ V P R L R L++V ++C SP P W K G+
Sbjct: 417 LLANAFVSVLDVPP---RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL 473
Query: 450 ENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDV 509
+ + E+G+L I + K D G YTC+ATN G A + L VKDPTR+ P
Sbjct: 474 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVA 533
Query: 510 TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK 569
G ++ L C+V HD SL + +W + D R+ +D + L I + +
Sbjct: 534 RRGTTVQLECRVKHDPSLKLTVSW------LKDDEPLYIGNRMKKEDDS--LTIFGVAER 585
Query: 570 HAGKYVCMVQTSVDRLSAAADLIVRG 595
G Y C+ T +D+ A A L V G
Sbjct: 586 DQGSYTCVASTELDQDLAKAYLTVLG 611
Score = 88.6 bits (218), Expect = 3e-17
Identities = 101/373 (27%), Positives = 156/373 (41%), Gaps = 38/373 (10%)
Query: 48 LNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFG 107
L C G P P I W G D+ + ++ +L I N ++ +D+G Y C A+N G
Sbjct: 266 LECIASGVPTPDIAWYKKGGDLPSDKA-KFENFNKALRITNVSE-EDSGEYFCLASNKMG 323
Query: 108 TI---VSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLC----GPPPHSGELSYAWIFN 160
+I +S K +LD K + + G+ L+C P P + W+ N
Sbjct: 324 SIRHTISVRVKAAPYWLDEPKN-----LILAPGEDGRLVCRANGNPKP-----TVQWMVN 373
Query: 161 EYPSYQDNRRFVSQETGNLYIAK-VEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGV 219
P + G+ I + + S Y C NT H L L N V
Sbjct: 374 GEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQC---NTSNEHGYL-------LANAFV 423
Query: 220 -MGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIW-RRADGKPIARKARRHKSN 277
+ + P++ + + +L+C G+P+PT+ W + G + N
Sbjct: 424 SVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYEN 483
Query: 278 GILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQ-PNWIQKINDIHVAME-ENVFW 335
G LEI ++ED G+Y CVA N GK A Q+ + P I ++ + VA V
Sbjct: 484 GSLEIKMIRKEDQGIYTCVATNILGK--AENQVRLEVKDPTRIYRMPEDQVARRGTTVQL 541
Query: 336 ECKANGRP--KPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVI 393
EC+ P K T WLK+ EPL +R++ E +L I V D G Y C+A +
Sbjct: 542 ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQD 601
Query: 394 FSNAELSVIAVGP 406
+ A L+V+ P
Sbjct: 602 LAKAYLTVLGNCP 614
Score = 70.9 bits (172), Expect = 6e-12
Identities = 73/307 (23%), Positives = 120/307 (39%), Gaps = 44/307 (14%)
Query: 320 QKINDIHVAMEENVFWECKANGRPKPTYKWLKNGE--PLLTRDRIQIEQGTLNITIVNLS 377
Q D V +N+ EC+A G P P++ W +N + R+ + + + + I S
Sbjct: 46 QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105
Query: 378 DA------GMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKP 431
G YQC A NK G SN ++ P + + L V +V+ G + ++C P
Sbjct: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV-VVQEGAPLTLQCNP 164
Query: 432 KAS-PKPVYTW-KKGRDILKENERITISEDGNLRIINVTKSDAGS-YTCIATNHF----- 483
P PV W + + +++R++ +G+L NV D + Y+C A HF
Sbjct: 165 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 224
Query: 484 -------------GTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIV 530
G A T + + T SS V G ++L C + + DI
Sbjct: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGT-----ASSQMVLRGMDLLLECIASGVPTPDI- 278
Query: 531 FTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAAD 590
W G D D FE L I N+ + +G+Y C+ + +
Sbjct: 279 -AWYKKGG--DLPSDKAKFENFNKA-----LRITNVSEEDSGEYFCLASNKMGSIRHTIS 330
Query: 591 LIVRGPP 597
+ V+ P
Sbjct: 331 VRVKAAP 337
Score = 58.5 bits (140), Expect = 3e-08
Identities = 48/157 (30%), Positives = 75/157 (47%), Gaps = 12/157 (7%)
Query: 45 KVKLNCEVKGNPKPHIRWKLN--GTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTA 102
+ +L+C G+P P +RW N G+++D G Y V E L + +D G Y C A
Sbjct: 447 RTRLDCPFFGSPIPTLRWFKNGQGSNLDGG---NYHVYENGSLEIKMIRKEDQGIYTCVA 503
Query: 103 TNSFGTIVSREAKLQFAYLDNFKT-RTRSTVSVRRGQGMVLLCG-PPPHSGELSYAWIFN 160
TN G E +++ D + R RRG + L C S +L+ +W+ +
Sbjct: 504 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560
Query: 161 EYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVT 197
+ P Y NR + +E +L I V + D G+YTCV +
Sbjct: 561 DEPLYIGNR--MKKEDDSLTIFGVAERDQGSYTCVAS 595
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 232 bits (592), Expect = 1e-60
Identities = 243/1003 (24%), Positives = 412/1003 (41%), Gaps = 94/1003 (9%)
Query: 45 KVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATN 104
+V L+C V G + W NG ++ G + R + + LI + D G YQC
Sbjct: 330 QVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRK 389
Query: 105 SFGTIVSREAKLQFAYLDNFKTRTRSTVS---VRRGQGMVLLCG----PPPHSGELSYAW 157
+S + +Q L++ + S S V + + L+C P P + W
Sbjct: 390 DK---LSAQDYVQVV-LEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLP-----TITW 440
Query: 158 IFNEYPSYQDNRRFVSQ---ETGN----LYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPT 210
++ P + +SQ GN L I+ + D G Y C N+
Sbjct: 441 TLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSA---------- 490
Query: 211 PLILRNDGVMGEYEPKIEVQFPETVPTAKGATV------KLECFALGNPVPTIIW-RRAD 263
GV+ Y+ +I V+ P ++ K T + C +G P +I W + ++
Sbjct: 491 -------GVV-LYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSN 542
Query: 264 GKPIARKARRHKSNGILEIPNFQQE-DAGLYECVAENSRGKNVARGQLTFYAQPNWIQKI 322
P + ++NG L++ + Q+E D G Y C + ++ P +IQ
Sbjct: 543 LLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPF 602
Query: 323 NDIHVAMEENVFWECKANGRPKP-TYKWLKNGEPL-----LTRDRIQIEQGTLNITIVNL 376
++ + VF C P T W K+G P+ +T D I +L I+ ++L
Sbjct: 603 EFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTS-SLRISNLSL 661
Query: 377 SDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPK 436
G Y C+A N+ + ++L ++ V P F + R G V++ C + P
Sbjct: 662 MHNGNYTCIARNEAAAVEHQSQL-IVRVPPKF--VVQPRDQDGIYGKAVILNCSAEGYPV 718
Query: 437 PVYTWK--KGRDI-----LKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGT-ASS 488
P WK KG + + N RI + +G+L I +V + D+G Y C +N G S
Sbjct: 719 PTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSK 778
Query: 489 TGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDH 548
+ L VK P + P++ T G+ + C T I+ W +I+ +
Sbjct: 779 SMYLTVKIPAMITSYPNTTLATQGQKKEMSC--TAHGEKPIIVRWEKEDRIIN----PEM 832
Query: 549 FERVGGQDSAGDLMIRNIQL-----KHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAV 603
+ G+ +I +Q+ + +G + C S L V+ PP PPE +
Sbjct: 833 ARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPE-I 891
Query: 604 TIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVG 663
I ++ T L W G D +SPIT Y I+ + S W + + + + +AT++
Sbjct: 892 EIKDVKARTITLRWTMGFDGNSPITGYDIECKNK-SDSWDSAQRTKD-VSPQLNSATIID 949
Query: 664 LNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETV 723
++P Y R A N IG EPS +EA P+ P V S + +TW+
Sbjct: 950 IHPSSTYSIRMYAKNRIGKSEPSNELTIT-ADEAAPDGPPQEVHLEPISSQSIRVTWKAP 1008
Query: 724 PEELQNGRGFGYVVAFRPYGK----MIWMLTVLASADASRYVFRNESVHPFSPFEVKVGV 779
+ LQNG GY + +R Y +++V S D+ Y N ++ F+ + + V
Sbjct: 1009 KKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDN--LNKFTQYGLVVQA 1066
Query: 780 FNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWAS-PLEKNRGRIQGYEV 838
N G GP S + + E+ P+ PP ++ A + S I + W++ E G +QG+ V
Sbjct: 1067 CNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRV 1126
Query: 839 KYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRK 898
YW + E Q S ++ L+ Y + V A+ AG G S + T++
Sbjct: 1127 IYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKE 1186
Query: 899 PPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSV 958
P P G +S S + ++W + L ++ Y V + S E + S
Sbjct: 1187 DVPGPPAGVKAAAASASMVFVSW--LPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSF 1244
Query: 959 ELSLP---FDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYAR 998
+P + Y + + + G G+SSE I + ++ A AR
Sbjct: 1245 SYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPAR 1287
Score = 165 bits (418), Expect = 2e-40
Identities = 215/916 (23%), Positives = 350/916 (38%), Gaps = 100/916 (10%)
Query: 41 SEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVV---EG---SLLINNPNKTQD 94
S + V L C VKG P P I W L+ + G R S + EG S L + ++ +D
Sbjct: 419 SPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRD 478
Query: 95 AGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPP--HSGE 152
G Y+CTA NS G + L + R S+R + + + G H
Sbjct: 479 GGVYRCTANNSAGVV-----------LYQARINVRGPASIRPMKNITAIAGRDTYIHCRV 527
Query: 153 LSY-----AWIFNEYPSYQDNRRFVSQETGNLYIAKVEKS-DVGNYTCVVTNTVTNHKVL 206
+ Y W N ++R+ + G L ++ V+K D G YTC VL
Sbjct: 528 IGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC---------NVL 578
Query: 207 GPPTPLILRNDGVMGEYEPKIE-VQFPETVPTAKGATVKLECFALGNPVP-TIIWRRADG 264
P ++ V + P I+ +FP + G V + C + +P TI W++ DG
Sbjct: 579 VQPQLSTSQSVHVTVKVPPFIQPFEFPR---FSIGQRVFIPCVVVSGDLPITITWQK-DG 634
Query: 265 KPIARKARRHKSN----GILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQ 320
+PI N L I N G Y C+A N + QL P ++
Sbjct: 635 RPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVV 694
Query: 321 KINDIHVAMEENVFWECKANGRPKPTYKW-------LKNGEPLLTRDRIQI-EQGTLNIT 372
+ D + V C A G P PT W + +P+ RIQ+ G+L I
Sbjct: 695 QPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIK 754
Query: 373 IVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPK 432
V D+G Y C N G S + + + T TL G + + C
Sbjct: 755 HVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMI--TSYPNTTLATQGQKKEMSCTAH 812
Query: 433 ASPKPVYTW-KKGRDILKENERITISED-------GNLRIINVTKSDAGSYTCIATNHFG 484
+ W K+ R I E R +S L+I+ + D+G ++C A N +G
Sbjct: 813 GEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYG 872
Query: 485 TASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDR 544
L V++ PP ++ + + ++ + +T F+G+
Sbjct: 873 EDRGIIQLTVQE------PPDPPEIEIKD--------VKARTITLRWTMGFDGNSPITGY 918
Query: 545 DGDHFERVGGQDSA----------GDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIV- 593
D + + DSA I +I + + + + +L +
Sbjct: 919 DIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTIT 978
Query: 594 ---RGPPGPPEAVTIDEITDTTAQLSWRPGPDNH---SPITMYVIQARTPFSVGWQAVST 647
P GPP+ V ++ I+ + +++W+ P H I Y I R + G +
Sbjct: 979 ADEAAPDGPPQEVHLEPISSQSIRVTWK-APKKHLQNGIIRGYQIGYREYSTGGNFQFNI 1037
Query: 648 VPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVS 707
+ G + T+ LN + +Y A N G G PS T E +P P NV
Sbjct: 1038 ISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG-PSSQEIITTTLEDVPSYPPENVQ 1096
Query: 708 GGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESV 767
S + I+W T+ +E NG G+ V + M L + + ++ + +
Sbjct: 1097 AIATSPESISISWSTLSKEALNGILQGFRVIYWA-NLMDGELGEIKNITTTQPSLELDGL 1155
Query: 768 HPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLE 827
++ + ++V F G+G S + E+ P PPA + A + SA+ + V W PL+
Sbjct: 1156 EKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVP-GPPAGVKAAAASASMVFVSWLPPLK 1214
Query: 828 KNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGP 887
N G I+ Y V + + + S +I NL + Y + V A SAG G
Sbjct: 1215 LN-GIIRKYTV--FCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGN 1271
Query: 888 SSATVNVTTRKPPPSQ 903
SS + V P++
Sbjct: 1272 SSEIITVEPLAKAPAR 1287
Score = 133 bits (335), Expect = 7e-31
Identities = 147/567 (25%), Positives = 235/567 (41%), Gaps = 62/567 (10%)
Query: 44 KKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTAT 103
++V+L C+ G+P+P RW + ++ F+ +V LLI N + D+G+Y C +
Sbjct: 240 QRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVT--GLLIENI-RPSDSGSYVCEVS 296
Query: 104 NSFGT--IVSREAKLQFAYLDNFKTRTRSTVSVRR-----GQGMVLLCGPPPHSGELSYA 156
N +GT ++ R Y+ K ++T+S R+ G + L C + +
Sbjct: 297 NRYGTAKVIGR------LYV---KQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQ-ELS 346
Query: 157 WIFN-EYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILR 215
W N E + N R NL + + KSD G Y C V K+ ++
Sbjct: 347 WYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKD----KLSAQDYVQVVL 402
Query: 216 NDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHK 275
DG PKI F E V + V L C G P+PTI W D PI +
Sbjct: 403 EDGT-----PKIISAFSEKV-VSPAEPVSLMCNVKGTPLPTITWT-LDDDPILKGGSHRI 455
Query: 276 SNGI---------LEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIH 326
S I L I + Q D G+Y C A NS G + + ++ P I+ + +I
Sbjct: 456 SQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG-PASIRPMKNIT 514
Query: 327 VAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQI---EQGTLNITIVNLS-DAGMY 382
+ + C+ G P + KW KN LL + Q+ GTL ++ V D G Y
Sbjct: 515 AIAGRDTYIHCRVIGYPYYSIKWYKNSN-LLPFNHRQVAFENNGTLKLSDVQKEVDEGEY 573
Query: 383 QCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPV-YTW 441
C + + S + + V P R + +G V I C + P+ TW
Sbjct: 574 TCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFS---IGQRVFIPCVVVSGDLPITITW 630
Query: 442 KKGRDILKENERITISE---DGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPT 498
+K + + +TI +LRI N++ G+YTCIA N L+V+ P
Sbjct: 631 QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPP 690
Query: 499 RVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQD-- 556
+ +V P D G++++L C IV+ +S + F + G+
Sbjct: 691 KFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIA-----LNGRIQV 745
Query: 557 -SAGDLMIRNIQLKHAGKYVCMVQTSV 582
S G L+I+++ + +G Y+C V V
Sbjct: 746 LSNGSLLIKHVVEEDSGYYLCKVSNDV 772
Score = 111 bits (278), Expect = 3e-24
Identities = 148/616 (24%), Positives = 237/616 (38%), Gaps = 49/616 (7%)
Query: 7 LLVLQSFILCLADDSTLHGPIFIQEPS--PVMFPLDSEEKKVKLNCEVKGNPKPHIRWKL 64
L + QSF ++D LH ++ S V+F + + C G P +RW L
Sbjct: 6 LSLFQSFANVFSED--LHSSLYFVNASLQEVVF---ASTTGTLVPCPAAGIPPVTLRWYL 60
Query: 65 -NGTDVDTGMDFRYSVVEGSLLI-----NNPNKTQDAGTYQCTATNSFGTIVSREAKLQF 118
G ++ R+ G+L I ++ + TY CTA N G I S++ ++
Sbjct: 61 ATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKA 120
Query: 119 AYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGN 178
+ + R ++R + P ++ + S RF+ TG
Sbjct: 121 VLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGA 180
Query: 179 LYIAKVEKSD-VGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPT 237
LYI V+ D + NY C+ + T L + + P I F
Sbjct: 181 LYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDP---ANSAPSILDGFDHRKAM 237
Query: 238 AKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVA 297
A G V+L C ALG+P P W + D P+ R K+ L I N + D+G Y C
Sbjct: 238 A-GQRVELPCKALGHPEPDYRWLK-DNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEV 295
Query: 298 ENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLL 357
N G G+L + ++ V C G W +NGE L
Sbjct: 296 SNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILN 355
Query: 358 TRDRIQ---IEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLK 414
++ I L + + SD G YQC +A+ V V D + ++
Sbjct: 356 PGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDK----LSAQDYVQVVLEDGTPKIIS 411
Query: 415 RVT--LVKVGGEVVIECKPKASPKPVYTWKKGRD-ILK-ENERIT--ISEDGN-LRIINV 467
+ +V V + C K +P P TW D ILK + RI+ I+ +GN + +N+
Sbjct: 412 AFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNI 471
Query: 468 TKS---DAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHD 524
+ S D G Y C A N G + V+ P + P ++ G + C+V
Sbjct: 472 SSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIR-PMKNITAIAGRDTYIHCRVIGY 530
Query: 525 HSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK-HAGKYVC--MVQTS 581
I W N +L+ F+ FE + G L + ++Q + G+Y C +VQ
Sbjct: 531 PYYSI--KWYKNSNLLPFNHRQVAFE------NNGTLKLSDVQKEVDEGEYTCNVLVQPQ 582
Query: 582 VDRLSAAADLIVRGPP 597
+ S + + V+ PP
Sbjct: 583 LS-TSQSVHVTVKVPP 597
Score = 84.3 bits (207), Expect = 5e-16
Identities = 99/395 (25%), Positives = 163/395 (41%), Gaps = 34/395 (8%)
Query: 228 EVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPI--ARKARRHKSNGILEIPNF 285
EV F T T + C A G P T+ W A G+ I R NG L+I F
Sbjct: 33 EVVFASTTGTL------VPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPF 86
Query: 286 QQEDAGL------YECVAENSRGKNVARG-QLTFYAQPNWIQKINDIHVAMEENVFWECK 338
Y C AEN GK ++ + + + ++ D ++C
Sbjct: 87 PPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCI 146
Query: 339 ANGRPKP---TYKWLKNGEPLLTRDRIQIEQ-GTLNITIVNLSDAGM-YQCLAENKHG-- 391
+ W K+ L++ R I G L I V D Y+C+ +++
Sbjct: 147 IPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGE 206
Query: 392 VIFSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTWKKGRDILK 449
SN+ ++ + + ++L K G V + CK P+P Y W K L+
Sbjct: 207 TRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLE 266
Query: 450 ENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDV 509
+ R + G L I N+ SD+GSY C +N +GTA G L VK P + + P +
Sbjct: 267 LSGRFQKTVTG-LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKS 325
Query: 510 TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK 569
+VG + L C VT ++ +W NG +++ ++ R+ G + +L++ ++
Sbjct: 326 SVGSQVSLSCSVTGTEDQEL--SWYRNGEILNPGKN----VRITGINHE-NLIMDHMVKS 378
Query: 570 HAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVT 604
G Y C V+ D+LSA + V G P+ ++
Sbjct: 379 DGGAYQCFVRK--DKLSAQDYVQVVLEDGTPKIIS 411
Score = 67.8 bits (164), Expect = 5e-11
Identities = 197/956 (20%), Positives = 331/956 (34%), Gaps = 148/956 (15%)
Query: 22 TLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKP-HIRWKLNGTDVDTGMDFRYSVV 80
T+ P FIQ P FP S ++V + C V P I W+ +G + + +
Sbjct: 592 TVKVPPFIQ---PFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNI 648
Query: 81 E--GSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQ 138
+ SL I+N + + G Y C A N V +++L F + R + G+
Sbjct: 649 DFTSSLRISNLSLMHN-GNYTCIARNE-AAAVEHQSQLIVRVPPKFVVQPRDQDGIY-GK 705
Query: 139 GMVLLCGPPPHSGELSYAWIFNE---YPSYQD---NRRFVSQETGNLYIAKVEKSDVGNY 192
++L C + + W F++ P +Q N R G+L I V + D G Y
Sbjct: 706 AVILNCSAEGYPVP-TIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYY 764
Query: 193 TCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGN 252
C V+N V + + P + +P T +G ++ C A G
Sbjct: 765 LCKVSNDVGAD----------VSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGE 814
Query: 253 PVPTIIWRRAD---GKPIARKARRHKSNGILEIPNFQ-----QEDAGLYECVAENSRGKN 304
+ W + D +AR K G I Q +ED+G + C A NS G++
Sbjct: 815 KPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGED 874
Query: 305 VARGQLTFYAQPNWIQ-KINDIHVAMEENVFWECKANGRPKPT---YKWLKNGEPLLTRD 360
QLT P+ + +I D+ A + W +G T + + +
Sbjct: 875 RGIIQLTVQEPPDPPEIEIKDVK-ARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQ 933
Query: 361 RIQIEQGTLN-ITIVNLSDAGMY--QCLAENKHGVIFSNAELSVIA--VGPDFSRTLLKR 415
R + LN TI+++ + Y + A+N+ G + EL++ A PD
Sbjct: 934 RTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPD-------- 985
Query: 416 VTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKEN---------ERITISEDGNLRIIN 466
G + +P +S TWK + L+ + + II+
Sbjct: 986 ------GPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIIS 1039
Query: 467 V-TKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPC------ 519
V T D+ YT N F + LVV+ R PSS ++ +P
Sbjct: 1040 VDTSGDSEVYTLDNLNKF----TQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENV 1095
Query: 520 QVTHDHSLDIVFTWS------FNGHLIDFD-------RDGDHFE-----------RVGGQ 555
Q I +WS NG L F DG+ E + G
Sbjct: 1096 QAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGL 1155
Query: 556 DSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQL 615
+ + I+ + AG V R PGPP V + + +
Sbjct: 1156 EKYTNYSIQVLAFTRAGDGV--------RSEQIFTRTKEDVPGPPAGVKAAAASASMVFV 1207
Query: 616 SWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTV 675
SW P + I Y + P+ P+ +F+ + L+ +Y V
Sbjct: 1208 SWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPD-----SFSYRIPNLSRNRQYSVWVV 1262
Query: 676 AANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKS-----ELVITWETVPEELQNG 730
A G G S + T E L + PA + G+ + ++V+ + V +
Sbjct: 1263 AVTSAGRGN----SSEIITVEPLAKA-PARILTFSGTVTTPWMKDIVLPCKAVGD----- 1312
Query: 731 RGFGYVVAFRPYGKMIWM-----LTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGE 785
P + WM L + D R +F N S + G ++
Sbjct: 1313 ----------PSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIAN 1362
Query: 786 GPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHED 845
+ ++ + + + + +++ I + W P + I+GY ++Y ED
Sbjct: 1363 NNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWL-PGDNGGSSIRGYILQY--SED 1419
Query: 846 KEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPP 901
E ++ S ++ NLK Y + A N G G S + T P
Sbjct: 1420 NSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEP 1475
Score = 66.6 bits (161), Expect = 1e-10
Identities = 76/335 (22%), Positives = 134/335 (40%), Gaps = 39/335 (11%)
Query: 463 RIINVTKSDAGSYTCIATNHFGTASSTGNLVV----KDPTRVMVPPSSMDVTVGESIVLP 518
RI N++++ S +A G +S+ + V K P R++ ++ + IVLP
Sbjct: 1247 RIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLP 1306
Query: 519 CQVTHDHSLDIVFTWSFNG--HLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVC 576
C+ D S + + NG L+ D F S G +IR ++ + +G Y C
Sbjct: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIF-------SNGSFIIRTVKAEDSGYYSC 1359
Query: 577 MVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQART 636
+ + +L V+ PP P +T+ + T ++ LSW PG + S I Y++Q
Sbjct: 1360 IANNNWGSDEIILNLQVQVPPDQPR-LTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSE 1418
Query: 637 PFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEE 696
S W + P +++ + W Y+F A N +G P R SE
Sbjct: 1419 DNSEQWGSFPISP---SERSYRLENLKCGTW--YKFTLTAQNGVG---PGRISE------ 1464
Query: 697 ALPEVTPANVSGGGGSKSELVITWETVPEELQ----NGRG---FGYVVAFRPYGKMIWML 749
+ E + EL + T L N G + + +RP+G +W
Sbjct: 1465 -IIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTT 1523
Query: 750 TVLASADASRYVFRNESVHPFSPFEVKVGVFNNKG 784
S S ++ + + +E+++ V N+ G
Sbjct: 1524 AQRTSLSKSYILY---DLQEATWYELQMRVCNSAG 1555
Score = 51.2 bits (121), Expect = 5e-06
Identities = 62/269 (23%), Positives = 104/269 (38%), Gaps = 40/269 (14%)
Query: 424 EVVIECKPKASPKPVYTWKKGRD----ILKENERITISEDGNLRIINVTKSDAGSYTCIA 479
++V+ CK P P W K + ++ + R +I +G+ I V D+G Y+CIA
Sbjct: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIA 1361
Query: 480 TNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTW------ 533
N++G+ NL +V VPP +TV ++ S I +W
Sbjct: 1362 NNNWGSDEIILNL------QVQVPPDQPRLTVSKTT----------SSSITLSWLPGDNG 1405
Query: 534 --SFNGHLIDFDRDGDHFERVGG---QDSAGDLMIRNIQLKHAGKYVCMVQTSV--DRLS 586
S G+++ + D E+ G S + N++ K+ Q V R+S
Sbjct: 1406 GSSIRGYILQYSEDNS--EQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRIS 1463
Query: 587 --AAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQA 644
A + + P E I T +L+ D PIT + ++ R PF G
Sbjct: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYR-PF--GTTV 1520
Query: 645 VSTVPELIDGKTFTATVVGLNPWVEYEFR 673
+T K++ + W E + R
Sbjct: 1521 WTTAQRTSLSKSYILYDLQEATWYELQMR 1549
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 228 bits (580), Expect = 3e-59
Identities = 274/1070 (25%), Positives = 437/1070 (40%), Gaps = 143/1070 (13%)
Query: 28 FIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVV-EGSLLI 86
F+ EP L V LNC P P I WK +GT ++ D R ++ +GSL I
Sbjct: 55 FLVEPVDT---LSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFI 111
Query: 87 NN----PNKTQDAGTYQCTAT-NSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMV 141
+N + D G YQC AT S GTI+SR AKL A L F ++ + SV G +
Sbjct: 112 SNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPS-SVYAGNNAI 170
Query: 142 LLCGPPPHSGELSYA-WIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTV 200
L C ++ + + W N P D+R + +G L I+ + D G Y CVV +
Sbjct: 171 LNC--EVNADLVPFVRWEQNRQPLLLDDR-VIKLPSGMLVISNATEGDGGLYRCVVESG- 226
Query: 201 TNHKVLGPPTPLILRNDGVMGEYEPKIEV-------QFPETVPTAKGATVKLECFALGNP 253
GPP +D V + P EV + P + G V L C A G P
Sbjct: 227 ------GPPK----YSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLP 276
Query: 254 VPTIIWRRADGKPIARKARRHK--SNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLT 311
PTI W + + + R + G LEI + ++DAG Y C+A+N A+ +LT
Sbjct: 277 TPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELT 336
Query: 312 FYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQI-EQGTLN 370
AQP ++++ +I+ ++ +EC+ G+P PT KW+KNG+ ++ D +I ++ L
Sbjct: 337 VQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQ 396
Query: 371 ITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKR-----VTLVKVGGEV 425
+ + SD G YQC+AEN G + A+L ++ P + L +LV
Sbjct: 397 VLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIK 456
Query: 426 VIECKPKASPK------PVYTWKKGRDILKENERITISEDGNLRII--NVTKSDAGSYTC 477
+ P + P V+ K+G I +E T S G +++ N+ + +
Sbjct: 457 LTWRTPASDPHGDNLTYSVFYTKEG--IARERVENT-SHPGEMQVTIQNLMPATVYIFRV 513
Query: 478 IATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNG 537
+A N G+ S+ L V+ V +P + ++ + VT + + S NG
Sbjct: 514 MAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPV------SGNG 567
Query: 538 HLIDF---------DRDGD-----HFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVD 583
+ ++ D++ D H + G + R + G V +V
Sbjct: 568 EIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVR 627
Query: 584 RLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRP--GPDNHSPITMYVIQARTPFSVG 641
LS P P+ ++++ + + W+P + IT Y I+ R
Sbjct: 628 TLSDV-------PSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKA---- 676
Query: 642 WQAVSTVPE-LIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPE 700
S V E L+ G + + GL+ EY FR A + G G + E L E
Sbjct: 677 -SRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDE 735
Query: 701 VTPANVSGGGGSK---SELVITWETVPEELQNGRGFGYVVAF---RPYGKMIWMLTVLAS 754
V + + +V++W P E QN GY + + P+ + I
Sbjct: 736 TRVPEVPSSLHVRPLVTSIVVSW--TPPENQNIVVRGYAIGYGIGSPHAQTI-------K 786
Query: 755 ADASRYVFRNESVHPFSPFEVKVGVFNNKGEG----------PFSPTTVV--------YS 796
D + + E++ P S + + + FNN GEG P + T+ V Y+
Sbjct: 787 VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYT 846
Query: 797 AEEEPT--KPPASIFARSLSATDIEVFWASPLEKNRGRI--QGYEVKYWRHEDKEENARK 852
+PT PP + A LS I + WA +I Y W+ + N +
Sbjct: 847 PVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK-TNIPANTKY 905
Query: 853 IRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNS 912
S +T LK + LY +V + S T + TT + P+ PP ++ S
Sbjct: 906 KNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVS 965
Query: 913 SDSK---IILNWDQVKALDNESEVKGYKVLYRW--NRQSSTSVIET---NKTSVEL-SLP 963
+ K II+NW + ++ GY + Y N + VIE N+ + ++ L
Sbjct: 966 KEGKPKTIIVNWQPPS--EANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELT 1023
Query: 964 FDEDYIIEIKPFSDGGDGSSSE--QIRIP------KISNAYARGSGASTS 1005
D Y +I+ + G G SE Q R P K+ N A GSG S
Sbjct: 1024 LDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGS 1073
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 209 bits (532), Expect = 1e-53
Identities = 213/768 (27%), Positives = 333/768 (43%), Gaps = 82/768 (10%)
Query: 176 TGNLYIAKV-----EKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQ 230
+G+L+ ++ K D G+Y CV N + + L D Q
Sbjct: 103 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFR---------Q 153
Query: 231 FPETVPTAKGATVKLECFA-LGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQED 289
P V A G LEC G+P PTI W++ + ++ R G L I N ++ D
Sbjct: 154 NPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSD 213
Query: 290 AGLYECVAENSRGKNVAR-GQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYK 348
AG+Y CV N G+ + +LT + +P ++++ + V EE V + C+ G P+PT +
Sbjct: 214 AGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVR 273
Query: 349 WLKNGEPLLTRDRIQIEQG-TLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPD 407
W K+ L R R I+ TL I +D G Y C+AEN+ G + ++A L+V A P
Sbjct: 274 WKKDDADL-PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP-PQ 331
Query: 408 FSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKK--GRDIL------KENERITISED 459
F + R +V G V C+ K +P+P W+K +++L + N R ++S
Sbjct: 332 F--VVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 389
Query: 460 GNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD------PTRVMVPPSSMDVTVGE 513
G+L I N+ +SDAG Y C A G+ + L V D P ++ P++ + V
Sbjct: 390 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG 449
Query: 514 SIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGK 573
+ +L C+ T D V +W G RD R Q+ G L I+N+++ G
Sbjct: 450 TALLKCKATGDPLP--VISWLKEGFTFP-GRD----PRATIQEQ-GTLQIKNLRISDTGT 501
Query: 574 YVCMVQTSVDRLSAAADLIVRGP-------------PGPPEAVTIDEITDTTAQLSWRPG 620
Y C+ +S S +A L V PGPP + ++T + LSW+PG
Sbjct: 502 YTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPG 561
Query: 621 PDNHSPITMYVIQARTP-FSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANV 679
P + Y+I+A + S WQ V+ KT TV GL P Y F A N
Sbjct: 562 TPGTLPASAYIIEAFSQSVSNSWQTVAN-----HVKTTLYTVRGLRPNTIYLFMVRAINP 616
Query: 680 IGIGEPSRPSEKRRTEEALPE---VTPANVSGGGGS-----KSELVITWETVPEELQNGR 731
G+ +PS S+ RT++ P V V G + +V+T TV R
Sbjct: 617 QGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDR 676
Query: 732 GFGYVVAFRPYGKMIWMLTVLAS---ADASRYVFRNE---SVHPFSPFEVKVGVFNNKGE 785
++ +R + L +S DA R+ ++ +E+KV + N+ +
Sbjct: 677 QPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQ 736
Query: 786 GPFSPTTVVYSAEEEPTKPPASI---FARSLSATDIEVFW-ASPLEKNRGRIQGYEVKYW 841
G S + V + EE P+ PP S+ S ++T I V W P + G IQ Y++
Sbjct: 737 GMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCL 796
Query: 842 RHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSS 889
+E + + + S I L + Y + V A SAG G S
Sbjct: 797 GNETRFHINKTVDAA--IRSVIIGGLFPGIQYRVEVAASTSAGVGVKS 842
Score = 198 bits (503), Expect = 2e-50
Identities = 151/492 (30%), Positives = 217/492 (44%), Gaps = 36/492 (7%)
Query: 26 PIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMD----FRYSVVE 81
P ++ PS V+ S+ + LNC+ +G P P I W +G V+T D R +
Sbjct: 47 PRIVEHPSDVIV---SKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 103
Query: 82 GSL----LINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRG 137
GSL +++ D G+Y C A N G VSR A L+ A L + + + V V G
Sbjct: 104 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 163
Query: 138 QGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVT 197
+ +L C PP E + W ++ D +S G L I+ KSD G YTCV T
Sbjct: 164 EPAILECQPPRGHPEPTIYWKKDKV-RIDDKEERISIRGGKLMISNTRKSDAGMYTCVGT 222
Query: 198 NTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTI 257
N V P L + +E ++ P + V+ C G+P PT+
Sbjct: 223 NMVGERD--SDPAELTV--------FERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTV 272
Query: 258 IWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPN 317
W++ D + R K + L I D G Y C+AEN GK A LT A P
Sbjct: 273 RWKKDDAD-LPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQ 331
Query: 318 WIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNG--------EPLLTRDRIQIE-QGT 368
++ + D VA V + C+ G P+P W K G +P R + G
Sbjct: 332 FVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD 391
Query: 369 LNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKR---VTLVKVGGEV 425
L IT + SDAG Y C A G I + A+L V V D ++ + + V G
Sbjct: 392 LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTA 451
Query: 426 VIECKPKASPKPVYTW-KKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFG 484
+++CK P PV +W K+G + R TI E G L+I N+ SD G+YTC+AT+ G
Sbjct: 452 LLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSG 511
Query: 485 TASSTGNLVVKD 496
S + L V +
Sbjct: 512 ETSWSAVLDVTE 523
Score = 166 bits (421), Expect = 8e-41
Identities = 214/833 (25%), Positives = 326/833 (39%), Gaps = 102/833 (12%)
Query: 222 EYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILE 281
++ P+I V+ P V +KG L C A G P PTI W + DG+ + +S+ +L
Sbjct: 44 DFPPRI-VEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVETDKDDPRSHRML- 100
Query: 282 IPNFQ------------QEDAGLYECVAENSRGKNVARGQLTFYA--QPNWIQKINDIHV 327
+P+ + D G Y CVA N G+ V+R A + ++ Q D+ V
Sbjct: 101 LPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVV 160
Query: 328 AMEENVFWECKA-NGRPKPTYKWLKNGEPLLTRD-RIQIEQGTLNITIVNLSDAGMYQCL 385
A E EC+ G P+PT W K+ + ++ RI I G L I+ SDAGMY C+
Sbjct: 161 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCV 220
Query: 386 AENKHGVIFSN-AELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKG 444
N G S+ AEL+V P F R + +V L + E C+ + P+P WKK
Sbjct: 221 GTNMVGERDSDPAELTVFE-RPTFLRRPINQVVLEEEAVE--FRCQVQGDPQPTVRWKKD 277
Query: 445 RDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPP 504
L R I +D LRI +D G+Y CIA N G ++ L V+ P + +V P
Sbjct: 278 DADLPRG-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP 336
Query: 505 SSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIR 564
V G ++ PC+ T + VF + F GDL I
Sbjct: 337 RDQIVAQGRTVTFPCE-TKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTIT 395
Query: 565 NIQLKHAGKYVCMVQTSVDRLSAAADLIV------RGPP----GPPEAVTIDEITDTTAQ 614
NIQ AG Y+C T + A A L V R PP GP D TA
Sbjct: 396 NIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTL---AVDGTAL 452
Query: 615 LSWRPGPDNHSPITM----YVIQARTP-FSVGWQAVSTVPELIDGKTFTATVVGLNPWVE 669
L + D I+ + R P ++ Q + L T T T V + E
Sbjct: 453 LKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGE 512
Query: 670 YEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQN 729
T + V+ + E K LP P+ +K+ + ++W+ P
Sbjct: 513 ----TSWSAVLDVTESGATISKNYDLSDLPG-PPSKPQVTDVTKNSVTLSWQ--PGTPGT 565
Query: 730 GRGFGYVV-AFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPF 788
Y++ AF W TV + Y R + P + + V N +G
Sbjct: 566 LPASAYIIEAFSQSVSNSWQ-TVANHVKTTLYTVR--GLRPNTIYLFMVRAINPQGLSDP 622
Query: 789 SPTTVVYSAEEEPTKPPA-------------SIFAR-----SLSATDIEVFWASPLEKNR 830
SP + ++ PPA + R L+ T ++V W +++
Sbjct: 623 SPMSDPVRTQD--ISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWT--VDRQP 678
Query: 831 GRIQGYEVKY-----------WRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKA 879
IQGY V Y W++ D + V + S + NLK V Y + V+
Sbjct: 679 QFIQGYRVMYRQTSGLQATSSWQNLDAK--------VPTERSAVLVNLKKGVTYEIKVRP 730
Query: 880 YNSAGTGPSSATVNVTTRKPPPSQPPGNI----IWNSSDSKIILNWDQVKALDNESEVKG 935
Y + G S + V T + PS PP ++ + + + + I ++WD ++
Sbjct: 731 YFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQE 790
Query: 936 YKV--LYRWNRQSSTSVIETNKTSVELSLPFDE-DYIIEIKPFSDGGDGSSSE 985
YK+ L R ++ SV + F Y +E+ + G G SE
Sbjct: 791 YKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSE 843
Score = 42.0 bits (97), Expect = 0.003
Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 9/111 (8%)
Query: 596 PPGPPEAVTIDEI---TDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELI 652
P PP++VT+ + T+ +SW P P +H +IQ + +G + + + +
Sbjct: 752 PSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQN---GIIQEYKIWCLGNETRFHINKTV 808
Query: 653 DGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSE---KRRTEEALPE 700
D + + GL P ++Y A+ G+G S P RR E + E
Sbjct: 809 DAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITE 859
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 209 bits (532), Expect = 1e-53
Identities = 213/768 (27%), Positives = 333/768 (43%), Gaps = 82/768 (10%)
Query: 176 TGNLYIAKV-----EKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQ 230
+G+L+ ++ K D G+Y CV N + + L D Q
Sbjct: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFR---------Q 137
Query: 231 FPETVPTAKGATVKLECFA-LGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQED 289
P V A G LEC G+P PTI W++ + ++ R G L I N ++ D
Sbjct: 138 NPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSD 197
Query: 290 AGLYECVAENSRGKNVAR-GQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYK 348
AG+Y CV N G+ + +LT + +P ++++ + V EE V + C+ G P+PT +
Sbjct: 198 AGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVR 257
Query: 349 WLKNGEPLLTRDRIQIEQG-TLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPD 407
W K+ L R R I+ TL I +D G Y C+AEN+ G + ++A L+V A P
Sbjct: 258 WKKDDADL-PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP-PQ 315
Query: 408 FSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKK--GRDIL------KENERITISED 459
F + R +V G V C+ K +P+P W+K +++L + N R ++S
Sbjct: 316 F--VVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
Query: 460 GNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD------PTRVMVPPSSMDVTVGE 513
G+L I N+ +SDAG Y C A G+ + L V D P ++ P++ + V
Sbjct: 374 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG 433
Query: 514 SIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGK 573
+ +L C+ T D V +W G RD R Q+ G L I+N+++ G
Sbjct: 434 TALLKCKATGDPLP--VISWLKEGFTFP-GRD----PRATIQEQ-GTLQIKNLRISDTGT 485
Query: 574 YVCMVQTSVDRLSAAADLIVRGP-------------PGPPEAVTIDEITDTTAQLSWRPG 620
Y C+ +S S +A L V PGPP + ++T + LSW+PG
Sbjct: 486 YTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPG 545
Query: 621 PDNHSPITMYVIQARTP-FSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANV 679
P + Y+I+A + S WQ V+ KT TV GL P Y F A N
Sbjct: 546 TPGTLPASAYIIEAFSQSVSNSWQTVAN-----HVKTTLYTVRGLRPNTIYLFMVRAINP 600
Query: 680 IGIGEPSRPSEKRRTEEALPE---VTPANVSGGGGS-----KSELVITWETVPEELQNGR 731
G+ +PS S+ RT++ P V V G + +V+T TV R
Sbjct: 601 QGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDR 660
Query: 732 GFGYVVAFRPYGKMIWMLTVLAS---ADASRYVFRNE---SVHPFSPFEVKVGVFNNKGE 785
++ +R + L +S DA R+ ++ +E+KV + N+ +
Sbjct: 661 QPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQ 720
Query: 786 GPFSPTTVVYSAEEEPTKPPASI---FARSLSATDIEVFW-ASPLEKNRGRIQGYEVKYW 841
G S + V + EE P+ PP S+ S ++T I V W P + G IQ Y++
Sbjct: 721 GMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCL 780
Query: 842 RHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSS 889
+E + + + S I L + Y + V A SAG G S
Sbjct: 781 GNETRFHINKTVDAA--IRSVIIGGLFPGIQYRVEVAASTSAGVGVKS 826
Score = 200 bits (508), Expect = 7e-51
Identities = 157/514 (30%), Positives = 225/514 (43%), Gaps = 40/514 (7%)
Query: 8 LVLQSFILCLADDSTLHG----PIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWK 63
L+L F+ D S L P ++ PS V+ S+ + LNC+ +G P P I W
Sbjct: 9 LLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIV---SKGEPTTLNCKAEGRPTPTIEWY 65
Query: 64 LNGTDVDTGMD----FRYSVVEGSL----LINNPNKTQDAGTYQCTATNSFGTIVSREAK 115
+G V+T D R + GSL +++ D G+Y C A N G VSR A
Sbjct: 66 KDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNAS 125
Query: 116 LQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQE 175
L+ A L + + + V V G+ +L C PP E + W ++ D +S
Sbjct: 126 LEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKV-RIDDKEERISIR 184
Query: 176 TGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETV 235
G L I+ KSD G YTCV TN V P L + +E ++ P
Sbjct: 185 GGKLMISNTRKSDAGMYTCVGTNMVGERD--SDPAELTV--------FERPTFLRRPINQ 234
Query: 236 PTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYEC 295
+ V+ C G+P PT+ W++ D + R K + L I D G Y C
Sbjct: 235 VVLEEEAVEFRCQVQGDPQPTVRWKKDDAD-LPRGRYDIKDDYTLRIKKTMSTDEGTYMC 293
Query: 296 VAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNG-- 353
+AEN GK A LT A P ++ + D VA V + C+ G P+P W K G
Sbjct: 294 IAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQ 353
Query: 354 ------EPLLTRDRIQIE-QGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGP 406
+P R + G L IT + SDAG Y C A G I + A+L V V
Sbjct: 354 NLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLT 413
Query: 407 DFSRTLLKR---VTLVKVGGEVVIECKPKASPKPVYTW-KKGRDILKENERITISEDGNL 462
D ++ + + V G +++CK P PV +W K+G + R TI E G L
Sbjct: 414 DRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTL 473
Query: 463 RIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD 496
+I N+ SD G+YTC+AT+ G S + L V +
Sbjct: 474 QIKNLRISDTGTYTCVATSSSGETSWSAVLDVTE 507
Score = 166 bits (421), Expect = 8e-41
Identities = 214/833 (25%), Positives = 326/833 (39%), Gaps = 102/833 (12%)
Query: 222 EYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILE 281
++ P+I V+ P V +KG L C A G P PTI W + DG+ + +S+ +L
Sbjct: 28 DFPPRI-VEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVETDKDDPRSHRML- 84
Query: 282 IPNFQ------------QEDAGLYECVAENSRGKNVARGQLTFYA--QPNWIQKINDIHV 327
+P+ + D G Y CVA N G+ V+R A + ++ Q D+ V
Sbjct: 85 LPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVV 144
Query: 328 AMEENVFWECKA-NGRPKPTYKWLKNGEPLLTRD-RIQIEQGTLNITIVNLSDAGMYQCL 385
A E EC+ G P+PT W K+ + ++ RI I G L I+ SDAGMY C+
Sbjct: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCV 204
Query: 386 AENKHGVIFSN-AELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKG 444
N G S+ AEL+V P F R + +V L + E C+ + P+P WKK
Sbjct: 205 GTNMVGERDSDPAELTVFE-RPTFLRRPINQVVLEEEAVE--FRCQVQGDPQPTVRWKKD 261
Query: 445 RDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPP 504
L R I +D LRI +D G+Y CIA N G ++ L V+ P + +V P
Sbjct: 262 DADLPRG-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP 320
Query: 505 SSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIR 564
V G ++ PC+ T + VF + F GDL I
Sbjct: 321 RDQIVAQGRTVTFPCE-TKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTIT 379
Query: 565 NIQLKHAGKYVCMVQTSVDRLSAAADLIV------RGPP----GPPEAVTIDEITDTTAQ 614
NIQ AG Y+C T + A A L V R PP GP D TA
Sbjct: 380 NIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTL---AVDGTAL 436
Query: 615 LSWRPGPDNHSPITM----YVIQARTP-FSVGWQAVSTVPELIDGKTFTATVVGLNPWVE 669
L + D I+ + R P ++ Q + L T T T V + E
Sbjct: 437 LKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGE 496
Query: 670 YEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQN 729
T + V+ + E K LP P+ +K+ + ++W+ P
Sbjct: 497 ----TSWSAVLDVTESGATISKNYDLSDLPG-PPSKPQVTDVTKNSVTLSWQ--PGTPGT 549
Query: 730 GRGFGYVV-AFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPF 788
Y++ AF W TV + Y R + P + + V N +G
Sbjct: 550 LPASAYIIEAFSQSVSNSWQ-TVANHVKTTLYTVR--GLRPNTIYLFMVRAINPQGLSDP 606
Query: 789 SPTTVVYSAEEEPTKPPA-------------SIFAR-----SLSATDIEVFWASPLEKNR 830
SP + ++ PPA + R L+ T ++V W +++
Sbjct: 607 SPMSDPVRTQD--ISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWT--VDRQP 662
Query: 831 GRIQGYEVKY-----------WRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKA 879
IQGY V Y W++ D + V + S + NLK V Y + V+
Sbjct: 663 QFIQGYRVMYRQTSGLQATSSWQNLDAK--------VPTERSAVLVNLKKGVTYEIKVRP 714
Query: 880 YNSAGTGPSSATVNVTTRKPPPSQPPGNI----IWNSSDSKIILNWDQVKALDNESEVKG 935
Y + G S + V T + PS PP ++ + + + + I ++WD ++
Sbjct: 715 YFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQE 774
Query: 936 YKV--LYRWNRQSSTSVIETNKTSVELSLPFDE-DYIIEIKPFSDGGDGSSSE 985
YK+ L R ++ SV + F Y +E+ + G G SE
Sbjct: 775 YKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSE 827
Score = 42.0 bits (97), Expect = 0.003
Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 9/111 (8%)
Query: 596 PPGPPEAVTIDEI---TDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELI 652
P PP++VT+ + T+ +SW P P +H +IQ + +G + + + +
Sbjct: 736 PSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQN---GIIQEYKIWCLGNETRFHINKTV 792
Query: 653 DGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSE---KRRTEEALPE 700
D + + GL P ++Y A+ G+G S P RR E + E
Sbjct: 793 DAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITE 843
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 207 bits (528), Expect = 3e-53
Identities = 220/863 (25%), Positives = 344/863 (39%), Gaps = 106/863 (12%)
Query: 14 ILCLADDSTLHG----PIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDV 69
++CL S L P ++ PS ++ S+ + LNC+ +G P P I W G V
Sbjct: 13 LICLCSGSRLRQEDFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERV 69
Query: 70 DTGMD----FRYSVVEGSL----LINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYL 121
+T D R + GSL +++ D G Y C A N G VS A L+ A L
Sbjct: 70 ETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL 129
Query: 122 DNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYI 181
+ + S V V G+ V+ C PP E + +W + P D ++ G L I
Sbjct: 130 RDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP-LDDKDERITIRGGKLMI 188
Query: 182 AKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGA 241
KSD G Y CV TN V + ++ R P V+ P +
Sbjct: 189 TYTRKSDAGKYVCVGTNMVGERESEVAELTVLER---------PSF-VKRPSNLAVTVDD 238
Query: 242 TVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSR 301
+ + +C A G+PVPT+ WR+ DG+ + + + + L+I D G Y CVAEN
Sbjct: 239 SAEFKCEARGDPVPTVRWRKDDGE-LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMV 297
Query: 302 GKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNG-------- 353
GK A LT P+++ K D VA+ V ++C+A G P+P W + G
Sbjct: 298 GKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 357
Query: 354 EPLLTRDRIQIEQ-GTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTL 412
+P + R + Q G L IT V SD G Y C N G I + A L V V D +
Sbjct: 358 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 417
Query: 413 LKRVTL---VKVGGEVVIECKPKASPKPVYTWKK-GRDILKENERITISEDGNLRIINVT 468
+++ + V V G V+ C SP P W+K G + ++ RI E+G L+I
Sbjct: 418 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 477
Query: 469 KSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLD 528
D G YTCIA+ G A+ + + V++ + PP D + S +VT
Sbjct: 478 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 537
Query: 529 IVFTW--SFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQ--------LKHAGKYVCMV 578
+ +W + N + F G S+ + N++ LK Y+ +V
Sbjct: 538 VTLSWQPNLNSGATPTSYIIEAFSHASG--SSWQTVAENVKTETSAIKGLKPNAIYLFLV 595
Query: 579 QTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYV----IQA 634
+ AA + P + V ++ T+ + + +++ + +
Sbjct: 596 R-------AANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLS 648
Query: 635 RTPFSVGWQAVSTVPELIDGKTFTATVVGLN----PWVEYEFRTVAANVIGIGE------ 684
+ V W V + I G G N W+ +E RT A N + I +
Sbjct: 649 SSSIEVHW-TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVN 707
Query: 685 ---PSRP---------SEKR--RTEEALPEVTP--ANVSGGGGSKSELVITWETVPEELQ 728
+RP SE + +T E P P VS G+ + ++++W+ PE+ Q
Sbjct: 708 YEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQ 767
Query: 729 NGRGFGYVVAFRPYGKMIWML------TVLASADASRYVFRNESVHPFSPFEVKVGVFNN 782
NG Y +W L + + D S + + P + V+V
Sbjct: 768 NGMVQEY---------KVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTG 818
Query: 783 KGEGPFS-PTTVVYSAEEEPTKP 804
G G S P + A P P
Sbjct: 819 AGSGVKSEPQFIQLDAHGNPVSP 841
Score = 204 bits (520), Expect = 3e-52
Identities = 216/780 (27%), Positives = 352/780 (45%), Gaps = 105/780 (13%)
Query: 176 TGNLYIAKV-----EKSDVGNYTCVVTN----TVTNHKVLGPPTPLILRNDGVMGEYEPK 226
+G+L+ ++ + D G Y CV N V+++ L ILR+D
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASL---EVAILRDDFR------- 134
Query: 227 IEVQFPETVPTAKGATVKLECFA-LGNPVPTIIWRRADGKPIARKARRHK-SNGILEIPN 284
Q P V A G +EC G+P PTI W++ DG P+ K R G L I
Sbjct: 135 ---QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRGGKLMITY 190
Query: 285 FQQEDAGLYECVAENSRGKNVAR-GQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRP 343
++ DAG Y CV N G+ + +LT +P+++++ +++ V ++++ ++C+A G P
Sbjct: 191 TRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 250
Query: 344 KPTYKWLKN-GEPLLTRDRIQI-EQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSV 401
PT +W K+ GE L + R +I + TL I V D G Y C+AEN G ++A L+V
Sbjct: 251 VPTVRWRKDDGE--LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Query: 402 IAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKK--GRDIL------KENER 453
P F + R +V +G V +C+ +P+P W++ +++L + + R
Sbjct: 309 -QEPPHF--VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 365
Query: 454 ITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD------PTRVMVPPSSM 507
++S+ G+L I NV +SD G Y C N G+ + L V D P + P +
Sbjct: 366 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 425
Query: 508 DVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQ 567
V V + VL C T I+ W +G L+ R+ ++ G L IR +
Sbjct: 426 TVAVDGTFVLSCVATGSPVPTIL--WRKDGVLVSTQDS-----RIKQLEN-GVLQIRYAK 477
Query: 568 LKHAGKYVCMVQTSVDRLSAAADLIVRG------PPGP------PEAVTIDEITDT---T 612
L G+Y C+ T + +A + V+ PP P P A + E+TD T
Sbjct: 478 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 537
Query: 613 AQLSWRPGPDNHSPITMYVIQARTPFS-VGWQAVSTVPELIDGKTFTATVVGLNPWVEYE 671
LSW+P ++ + T Y+I+A + S WQ V+ + KT T+ + GL P Y
Sbjct: 538 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAE-----NVKTETSAIKGLKPNAIYL 592
Query: 672 FRTVAANVIGIGEPSRPSEKRRTEEALPE---VTPANVSGGGG------------SKSEL 716
F AAN GI +PS+ S+ +T++ LP V V G S S +
Sbjct: 593 FLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSI 652
Query: 717 VITWETVPEELQNGRGFGYVVAFRP----YGKMIWMLTVLASADASRYVFRNESVHPFSP 772
+ W TV ++ Q + GY + +RP +G+ W++ + + + V +
Sbjct: 653 EVHW-TVDQQSQYIQ--GYKILYRPSGANHGESDWLVFEVRTPAKNSVVI--PDLRKGVN 707
Query: 773 FEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPP--ASIFARSLSATDIEVFWASPLEKNR 830
+E+K F N+ +G S + EE P+ PP ++ + T I V W P E +
Sbjct: 708 YEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQ 767
Query: 831 -GRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSS 889
G +Q Y+V +E + + + G+ S I L + Y + V A AG+G S
Sbjct: 768 NGMVQEYKVWCLGNETRYHINKTVD--GSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 825
Score = 34.3 bits (77), Expect = 0.62
Identities = 49/211 (23%), Positives = 87/211 (41%), Gaps = 36/211 (17%)
Query: 801 PTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQT 860
P+KP + +S + + W L Y ++ + H V +T
Sbjct: 525 PSKPEVT----DVSRNTVTLSWQPNLNSG-ATPTSYIIEAFSHASGSSWQTVAENVKTET 579
Query: 861 STKITNLKGSVLYHLAVKAYNSAG-TGPSSATVNVTTRKPPPSQPP----------GNII 909
S I LK + +Y V+A N+ G + PS + V T+ P+ GN +
Sbjct: 580 SA-IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAV 638
Query: 910 WNS------SDSKIILNWDQVKALDNESE-VKGYKVLYR---WNRQSSTSVIETNKTSVE 959
+ S S I ++W +D +S+ ++GYK+LYR N S ++ +T +
Sbjct: 639 LHLHNPTVLSSSSIEVHW----TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAK 694
Query: 960 LSLPFDE-----DYIIEIKPFSDGGDGSSSE 985
S+ + +Y I+ +PF + G+ SE
Sbjct: 695 NSVVIPDLRKGVNYEIKARPFFNEFQGADSE 725
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 207 bits (528), Expect = 3e-53
Identities = 240/1009 (23%), Positives = 411/1009 (40%), Gaps = 105/1009 (10%)
Query: 46 VKLNCEVKGNPKPHIRWKLNGTDV--DTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTAT 103
V L+C + G+P+ IRW N V D + R + +LLI + K+ +G YQC AT
Sbjct: 392 VILSCALTGSPEFTIRWYRNTELVLPDEAISIR-GLSNETLLITSAQKSH-SGAYQCFAT 449
Query: 104 NSFGTIVSREAKLQFAYLDNFKTRTRSTVS---VRRGQGMVLLCG----PPPHSGELSYA 156
T L++ R S+ S V G+ L+C PPP +
Sbjct: 450 RKAQTAQD----FAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPP-----TVT 500
Query: 157 WIFNEYPSYQDNRRFVSQET-------GNLYIAKVEKSDVGNYTCVVTNTVTNHK----- 204
W ++ P +D +Q T ++ + + D G Y C N V + +
Sbjct: 501 WALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARI 560
Query: 205 -VLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRAD 263
V GPP+ +RN + G + C +G P +I W + D
Sbjct: 561 NVRGPPSIRAMRN------------------ITAVAGRDTLINCRVIGYPYYSIKWYK-D 601
Query: 264 GKPIARKARRHK-SNGILEIPNFQQE-DAGLYECVAENSRGKNVARGQLTFYAQPNWIQK 321
+ R+ NG L++ + Q+ D G Y C ++++ P IQ
Sbjct: 602 ALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQP 661
Query: 322 INDIHVAMEENVFWECKANGRPKPT-YKWLKNGEPLLTRDRIQIEQ----GTLNITIVNL 376
++ + ++ C + P W K+G+ +++ + IE +L I+ V+L
Sbjct: 662 FEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSL 721
Query: 377 SDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPK 436
G Y C+A N + +L ++ V P F + + G V+ C P
Sbjct: 722 KHNGNYTCIASNAAATVSRERQL-IVRVPPRFVVQPNNQDGIYGKAG--VLNCSVDGYPP 778
Query: 437 PVYTWKKGRDILKENE--------RITISEDGNLRIINVTKSDAGSYTCIATNHFGT-AS 487
P WK + + RI I + +L I +V + D G Y C A+N GT S
Sbjct: 779 PKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDIS 838
Query: 488 STGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGD 547
+ L VK P + P++ G + L C + I+ W +ID DR
Sbjct: 839 KSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERP--IIIRWEKGDTVIDPDRVMR 896
Query: 548 HFERVGGQDSAGDLMIRNIQLKHAGK-----YVCMVQTSVDRLSAAADLIVRGPPGPPEA 602
+ + +D+ GD ++ ++LK A + + C S L V+ PP PPE
Sbjct: 897 Y--AIATKDN-GDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPE- 952
Query: 603 VTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGW---QAVSTVPELIDGKTFTA 659
+ I E+ + L W D +S IT + I+ + S W Q+ + I+ A
Sbjct: 953 LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNK-SDSWDFKQSTRNISPTIN----QA 1007
Query: 660 TVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVIT 719
+V L+P Y R + N IG EPS+ TEEA P+ P +V+ + + +T
Sbjct: 1008 NIVDLHPASVYSIRMYSFNKIGRSEPSKELTIS-TEEAAPDGPPMDVTLQPVTSQSIQVT 1066
Query: 720 WETVPEELQNGRGFGYVVAFRPYGK----MIWMLTVLASADASRYVFRNESVHPFSPFEV 775
W+ +ELQNG GY + +R ++ + A+ D+ Y N + F+ + V
Sbjct: 1067 WKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDN--LKKFAQYGV 1124
Query: 776 KVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKN-RGRIQ 834
V FN G GP S + E+ P++PP ++ A S+++ + W+ P G ++
Sbjct: 1125 VVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLK 1184
Query: 835 GYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNV 894
GY V +W E + ++ ++ Y + V AY AG G S+ + +
Sbjct: 1185 GYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYI 1244
Query: 895 TTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYR--WNRQSSTSVIE 952
T++ P P G SS S ++++W + ++ Y + + Q + S E
Sbjct: 1245 QTKEDVPGPPAGIKAVPSSASSVVVSW--LPPTKPNGVIRKYTIFCSSPGSGQPAPSEYE 1302
Query: 953 TNKTSVELSLPF---DEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYAR 998
T+ + + + Y++ + + G G+SSE++ I A A+
Sbjct: 1303 TSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAK 1351
Score = 148 bits (373), Expect = 3e-35
Identities = 218/924 (23%), Positives = 348/924 (37%), Gaps = 111/924 (12%)
Query: 44 KKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFR---YSVVEGSLLINNPNKT----QDAG 96
++ L C KG P P + W L+ + R Y++ +G+ I++ N T +D G
Sbjct: 483 EQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGT-TISHMNVTGPQIRDGG 541
Query: 97 TYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLC---GPPPHSGEL 153
Y+CTA N G S E + + R ++ G+ ++ C G P +
Sbjct: 542 VYRCTARNLVG---SAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYY---- 594
Query: 154 SYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKS-DVGNYTCVVTNTVTNHKVLGPPTPL 212
S W + + DN R V E G L + V+K D G Y C VL P
Sbjct: 595 SIKW-YKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC---------SVLIQPQLS 644
Query: 213 ILRNDGVMGEYEPKIE-VQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKA 271
I ++ V + P I+ +FP P + G + + C +P I R DG+ I +
Sbjct: 645 ISQSVHVAVKVPPLIQPFEFP---PASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGS 701
Query: 272 ----RRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHV 327
+ L+I + + G Y C+A N+ QL P ++ + N+
Sbjct: 702 GVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDG 761
Query: 328 AMEENVFWECKANGRPKPTYKWL--------KNGEPLLTRDRIQI-EQGTLNITIVNLSD 378
+ C +G P P W + P+ RIQI +L I V D
Sbjct: 762 IYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEED 821
Query: 379 AGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPV 438
G Y C A N G S + + + T T+ G + C + +
Sbjct: 822 IGYYLCQASNGVGTDISKSMFLTVKIPAMI--TSHPNTTIAIKGHAKELNCTARGERPII 879
Query: 439 YTWKKGRDILKENE--RITISEDGN-------LRIINVTKSDAGSYTCIATNHFGTASST 489
W+KG ++ + R I+ N L++ + D+ ++C A N +G
Sbjct: 880 IRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGL 939
Query: 490 GNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLI--DFD---- 543
L V++P PP L + S+++ +T F+G+ I FD
Sbjct: 940 IQLTVQEPPD---PPE-----------LEIREVKARSMNLRWTQRFDGNSIITGFDIEYK 985
Query: 544 --RDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQT--SVDRLSAAADLIV----RG 595
D F++ S + L A Y + + + R + +L +
Sbjct: 986 NKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAA 1045
Query: 596 PPGPPEAVTIDEITDTTAQLSWRPGPD--NHSPITMYVIQAR--TPFSVGWQAVSTVPEL 651
P GPP VT+ +T + Q++W+ + I Y I R +P S G ++ +
Sbjct: 1046 PDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKAT 1105
Query: 652 IDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGG 711
D + + T+ L + +Y A N G G PS T E +P P NV
Sbjct: 1106 GDSEVY--TLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINATTLEDVPSQPPENVRALSI 1162
Query: 712 SKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTV------LASADASRYVFRNE 765
+ VI+W P NG GY V F W L V + + +R
Sbjct: 1163 TSDVAVISWSEPPRSTLNGVLKGYRVIF-------WSLYVDGEWGEMQNITTTRERVELR 1215
Query: 766 SVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASP 825
+ F+ + V+V + G+G S + + E+ P PPA I A SA+ + V W P
Sbjct: 1216 GMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP-GPPAGIKAVPSSASSVVVSWLPP 1274
Query: 826 LEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGT 885
+ N G I+ Y + + + T Q +I +L Y L V A SAG
Sbjct: 1275 TKPN-GVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGR 1333
Query: 886 GPSSATVNVTTRKPPPSQPPGNII 909
G SS V + P + P II
Sbjct: 1334 GNSSEKVTI----EPAGKAPAKII 1353
Score = 136 bits (342), Expect = 1e-31
Identities = 139/498 (27%), Positives = 208/498 (41%), Gaps = 49/498 (9%)
Query: 46 VKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNS 105
V+L C G P P IRW +G + D R++ L I++ +T+D+GTY C TN+
Sbjct: 303 VELPCTASGYPIPAIRWLKDGRPLPA--DSRWTKRITGLTISDL-RTEDSGTYICEVTNT 359
Query: 106 FGTIVSREAKLQFAYLDNFK-TRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNE--- 161
FG S EA +D T T + G ++L C S E + W N
Sbjct: 360 FG---SAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTG-SPEFTIRWYRNTELV 415
Query: 162 YPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMG 221
P + R +S ET L I +KS G Y C T + +I DG
Sbjct: 416 LPDEAISIRGLSNET--LLITSAQKSHSGAYQCFATRKAQTAQDFA----IIALEDGT-- 467
Query: 222 EYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGI-- 279
P+I F E V G L C A G P PT+ W D +PI R H++N
Sbjct: 468 ---PRIVSSFSEKVVNP-GEQFSLMCAAKGAPPPTVTWA-LDDEPIVRDGS-HRTNQYTM 521
Query: 280 --------LEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEE 331
+ + Q D G+Y C A N G + ++ P+ I+ + +I
Sbjct: 522 SDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS-IRAMRNITAVAGR 580
Query: 332 NVFWECKANGRPKPTYKWLKNGEPLLTRDR-IQIEQGTLNITIVNLS-DAGMYQCLAENK 389
+ C+ G P + KW K+ L R + E GTL +T V D G Y C +
Sbjct: 581 DTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQ 640
Query: 390 HGVIFSNAELSVIAVGPDFSRTLLKRVTL--VKVGGEVVIECKPKASPKPV-YTWKKGRD 446
+ S + + V P L++ +G + I C + P+ TW+K
Sbjct: 641 PQLSISQSVHVAVKVPP-----LIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQ 695
Query: 447 ILKENERITISED---GNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVP 503
++ +TI +L+I +V+ G+YTCIA+N T S L+V+ P R +V
Sbjct: 696 VIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQ 755
Query: 504 PSSMDVTVGESIVLPCQV 521
P++ D G++ VL C V
Sbjct: 756 PNNQDGIYGKAGVLNCSV 773
Score = 129 bits (325), Expect = 1e-29
Identities = 149/585 (25%), Positives = 236/585 (40%), Gaps = 63/585 (10%)
Query: 46 VKLNCEVKGNPKPHIRWKL-NGTDVDTGMDFRYSVVEGSLLIN--NP---NKTQDAGTYQ 99
V + C G+P +RW L G D+ R+ G+L + +P N Y
Sbjct: 103 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYF 162
Query: 100 CTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELS--YAW 157
CTA N+ G I S +++ + + + R S+R G V C P E +W
Sbjct: 163 CTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMR-GNVAVFKCLIPSSVQEYVSVVSW 221
Query: 158 IFNEYPSYQDNRRFVSQETGNLYIAKVEKSD-VGNYTCVVTNTVTNHKVLGPPTPLILRN 216
+ ++R F++ G LYI+ V+K D + Y C +T HK G ++
Sbjct: 222 EKDTVSIIPEHRFFITYH-GGLYISDVQKEDALSTYRC-----ITKHKYSGETR----QS 271
Query: 217 DGVMGEYEPKIEVQFP-ETVPTA----------KGATVKLECFALGNPVPTIIWRRADGK 265
+G ++ V P E++PT G TV+L C A G P+P I W + DG+
Sbjct: 272 NGA------RLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLK-DGR 324
Query: 266 PIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDI 325
P+ +R K L I + + ED+G Y C N+ G A G L + +
Sbjct: 325 PLPADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKL 384
Query: 326 HVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQI---EQGTLNITIVNLSDAGMY 382
+ V C G P+ T +W +N E +L + I I TL IT S +G Y
Sbjct: 385 KTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAY 444
Query: 383 QCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWK 442
QC A K A +++ P + ++V V G + + C K +P P TW
Sbjct: 445 QCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKV--VNPGEQFSLMCAAKGAPPPTVTWA 502
Query: 443 KG-----RDILKENERITISEDGNLRIINVTK---SDAGSYTCIATNHFGTASSTGNLVV 494
RD + T+S+ + +NVT D G Y C A N G+A + V
Sbjct: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562
Query: 495 KDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGG 554
+ P + ++ G ++ C+V I W + L+ + FE
Sbjct: 563 RGPPSIRA-MRNITAVAGRDTLINCRVIGYPYYSI--KWYKDALLLPDNHRQVVFEN--- 616
Query: 555 QDSAGDLMIRNIQL-KHAGKYVCMVQTSVD-RLSAAADLIVRGPP 597
G L + ++Q G+Y+C V +S + + V+ PP
Sbjct: 617 ----GTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPP 657
Score = 79.0 bits (193), Expect = 2e-14
Identities = 89/363 (24%), Positives = 146/363 (40%), Gaps = 28/363 (7%)
Query: 233 ETVPTAKGATVKLECFALGNPVPTIIWRRADGKPI--ARKARRHKSNGILEIPNFQQEDA 290
+ V + V + C A G+P + W A G I R +NG L++ F
Sbjct: 93 QQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAF 152
Query: 291 GL------YECVAENSRGKNVARG-QLTFYAQPNWIQKINDIHVAMEENVFWECKANGRP 343
Y C AEN+ GK + ++ + + ++ D ++C
Sbjct: 153 NSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSV 212
Query: 344 KP---TYKWLKNGEPLLTRDRIQIE-QGTLNITIVNLSDA-GMYQCLAENKHG--VIFSN 396
+ W K+ ++ R I G L I+ V DA Y+C+ ++K+ SN
Sbjct: 213 QEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSN 272
Query: 397 AELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTWKKGRDILKENERI 454
+ + T+L +V G V + C P P W K L + R
Sbjct: 273 GARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRW 332
Query: 455 TISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGES 514
T G L I ++ D+G+Y C TN FG+A +TG L+V DP V + P + +G +
Sbjct: 333 TKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGST 391
Query: 515 IVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGD-LMIRNIQLKHAGK 573
++L C +T S + W N L+ D E + + + + L+I + Q H+G
Sbjct: 392 VILSCALT--GSPEFTIRWYRNTELVLPD------EAISIRGLSNETLLITSAQKSHSGA 443
Query: 574 YVC 576
Y C
Sbjct: 444 YQC 446
Score = 46.2 bits (108), Expect = 2e-04
Identities = 67/282 (23%), Positives = 106/282 (37%), Gaps = 49/282 (17%)
Query: 424 EVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIIN---------VTKSDAGS 474
+V + C P P W K E+ I +S DG+ R+I+ V D+G
Sbjct: 1366 DVRLPCNSVGDPAPAVKWTKD----SEDSAIPVSMDGH-RLIHTNGTLLLRAVKAEDSGY 1420
Query: 475 YTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTW- 533
YTC ATN G + NL+V+ VPP +TV ++ + I TW
Sbjct: 1421 YTCTATNTGGFDTIIVNLLVQ------VPPDQPRLTVSKT----------SASSITLTWI 1464
Query: 534 -------SFNGHLIDFDRD-GDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSV--D 583
S G ++ + D + ++ V S + +++ K + SV
Sbjct: 1465 PGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSG 1524
Query: 584 RLSAAADLIVRG--PPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVG 641
R+S + G P + I T A+L+ + + PIT V++ R +
Sbjct: 1525 RISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWA 1584
Query: 642 WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIG 683
WQ + G+ F + L YE R A N G G
Sbjct: 1585 WQGLRANS---SGEVF---LTELREATWYELRMRACNSAGCG 1620
Score = 43.9 bits (102), Expect = 8e-04
Identities = 24/71 (33%), Positives = 36/71 (50%), Gaps = 4/71 (5%)
Query: 44 KKVKLNCEVKGNPKPHIRWKLNGTD--VDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCT 101
K V+L C G+P P ++W + D + MD + L+ K +D+G Y CT
Sbjct: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
Query: 102 ATNS--FGTIV 110
ATN+ F TI+
Sbjct: 1425 ATNTGGFDTII 1435
Score = 41.2 bits (95), Expect = 0.005
Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 4/78 (5%)
Query: 229 VQFPETVPTAKGATVKLECFALGNPVPTIIWRR-ADGKPIARKARRHK---SNGILEIPN 284
+ F TV T V+L C ++G+P P + W + ++ I H+ +NG L +
Sbjct: 1353 ISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRA 1412
Query: 285 FQQEDAGLYECVAENSRG 302
+ ED+G Y C A N+ G
Sbjct: 1413 VKAEDSGYYTCTATNTGG 1430
Score = 38.5 bits (88), Expect = 0.033
Identities = 29/98 (29%), Positives = 41/98 (41%), Gaps = 11/98 (11%)
Query: 337 CKANGRPKPTYKWLKNGEPL-----LTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHG 391
C + G P P KW K+ E + R+ GTL + V D+G Y C A N G
Sbjct: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
Query: 392 VIFSNAELSVIAVGPD-----FSRTLLKRVTLVKVGGE 424
L ++ V PD S+T +TL + G+
Sbjct: 1431 FDTIIVNL-LVQVPPDQPRLTVSKTSASSITLTWIPGD 1467
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,932,985
Number of Sequences: 37866
Number of extensions: 2096886
Number of successful extensions: 18566
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 281
Number of HSP's successfully gapped in prelim test: 256
Number of HSP's that attempted gapping in prelim test: 5956
Number of HSP's gapped (non-prelim): 4785
length of query: 1026
length of database: 18,247,518
effective HSP length: 112
effective length of query: 914
effective length of database: 14,006,526
effective search space: 12801964764
effective search space used: 12801964764
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.