Guide to the Human Genome
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Search of human proteins with 28269672

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|28269672 serologically defined colon cancer antigen 8 [Homo
sapiens]
         (713 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|28269672 serologically defined colon cancer antigen 8 [Homo s...  1385   0.0  
gi|153791839 sodium channel associated protein 1 [Homo sapiens]       106   9e-23
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            103   7e-22
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     98   3e-20
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    97   5e-20
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    97   5e-20
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        97   5e-20
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        97   5e-20
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         97   5e-20
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         97   5e-20
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         97   5e-20
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         97   5e-20
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         97   5e-20
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         97   5e-20
gi|32698688 citron [Homo sapiens]                                      96   9e-20
gi|148746195 trichohyalin [Homo sapiens]                               94   3e-19
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    94   4e-19
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    94   4e-19
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    92   1e-18
gi|4885583 Rho-associated, coiled-coil containing protein kinase...    92   1e-18
gi|31982906 cingulin-like 1 [Homo sapiens]                             92   1e-18
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    92   2e-18
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...    92   2e-18
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     92   2e-18
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    92   2e-18
gi|21735548 centrosomal protein 2 [Homo sapiens]                       91   3e-18
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    91   4e-18
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    91   4e-18
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                   91   4e-18
gi|38044112 restin isoform b [Homo sapiens]                            91   5e-18

>gi|28269672 serologically defined colon cancer antigen 8 [Homo
           sapiens]
          Length = 713

 Score = 1385 bits (3585), Expect = 0.0
 Identities = 713/713 (100%), Positives = 713/713 (100%)

Query: 1   MAKSPENSTLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNED 60
           MAKSPENSTLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNED
Sbjct: 1   MAKSPENSTLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNED 60

Query: 61  ARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVH 120
           ARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVH
Sbjct: 61  ARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVH 120

Query: 121 TINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLD 180
           TINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLD
Sbjct: 121 TINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLD 180

Query: 181 ASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEE 240
           ASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEE
Sbjct: 181 ASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEE 240

Query: 241 SQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNV 300
           SQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNV
Sbjct: 241 SQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNV 300

Query: 301 HMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQ 360
           HMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQ
Sbjct: 301 HMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQ 360

Query: 361 CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEA 420
           CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEA
Sbjct: 361 CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEA 420

Query: 421 QVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRA 480
           QVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRA
Sbjct: 421 QVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRA 480

Query: 481 KTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQ 540
           KTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQ
Sbjct: 481 KTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQ 540

Query: 541 EKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLK 600
           EKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLK
Sbjct: 541 EKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLK 600

Query: 601 EECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMK 660
           EECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMK
Sbjct: 601 EECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMK 660

Query: 661 QRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQSDC 713
           QRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQSDC
Sbjct: 661 QRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQSDC 713


>gi|153791839 sodium channel associated protein 1 [Homo sapiens]
          Length = 688

 Score =  106 bits (264), Expect = 9e-23
 Identities = 131/634 (20%), Positives = 263/634 (41%), Gaps = 94/634 (14%)

Query: 118 LVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQ-------- 169
           L   + +  +++  L  ++K+ ++++  MK +++ V+ ENE L  +LK   +        
Sbjct: 56  LAPLVTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPL 115

Query: 170 -----------EETLRE-------------------QTLLDASGNMHNSWITTGEDSGVG 199
                      +ET+R                    QT+      +H  +     ++ + 
Sbjct: 116 GTEVGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIH 175

Query: 200 ETSKRPFSHDNADFGKAAS----AGEQLELEK---LKLTYEEKCEIEESQLKFLRNDLA- 251
               +       DF +         E +E+     LK   E+   IE+ + K  +  L  
Sbjct: 176 VFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLEL 235

Query: 252 --------EYQRTCEDLKEQLKHKEF-LLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHM 302
                   E     EDL+ Q+K KE  +++A+         L+  Q      +    V +
Sbjct: 236 RVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTI 295

Query: 303 QTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCD 362
           Q   +L  E   L      +++   + +     A  + +  +Q+ EEAN +K++AL++  
Sbjct: 296 QEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEK 355

Query: 363 QLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQV 422
           Q  +++E+  E + + +     +   E    KK+   +   +  ++  L    A+ + Q+
Sbjct: 356 QKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQI 415

Query: 423 EKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDE-------AEKEH 475
           E+V KEK +   +LE+I  +    E D  K+  EM  +   +   KD+       AE   
Sbjct: 416 ERVIKEKKAVEEELEKIYREGRGNESDYRKL-EEMHQRFLVSERSKDDLQLRLTRAENRI 474

Query: 476 REFRAKTNRDLEIKDQEIEKLRIELDE--------SKQHLEQEQQKAALARE-ECLRLTE 526
           ++    ++ ++    + I+KL+  L+         S+Q L+ +Q+   L +E E LR   
Sbjct: 475 KQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIA 534

Query: 527 LLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQY 586
           L  + + ++ ++  E +     FS   K +  + Q RE E + +   +E +H        
Sbjct: 535 LEAQKKAKVKISTMEHE-----FS--IKERGFEVQLREMEDSNRNSIVELRH-------- 579

Query: 587 LLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNE--- 643
            LL +Q     + KEE   L +  E      +SE   LS++K +T + L +L+  NE   
Sbjct: 580 -LLATQQKAANRWKEETKKLTESAEIRINNLKSE---LSRQKLHTQELLSQLEMANEKVA 635

Query: 644 ELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQL 677
           E E+  ++H      +++RL Q ++ + + +QQL
Sbjct: 636 ENEKLILEHQEKANRLQRRLSQAEERAASASQQL 669


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  103 bits (256), Expect = 7e-22
 Identities = 154/744 (20%), Positives = 310/744 (41%), Gaps = 87/744 (11%)

Query: 13   ILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAWPE-LQQS 71
            +L Q Q          + QLT  LK    +  +   NL           R A    L   
Sbjct: 562  VLNQLQEK-NHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLE 620

Query: 72   HAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHH 131
             +VN+L   L +  +K S++    + K   L S E  +T      DL + ++     +  
Sbjct: 621  TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA--DLQNHLDTAQNALQD 678

Query: 132  LEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWIT 191
             + E+     +L  +  K+Q        L+  LK  +++    EQ   +  G +      
Sbjct: 679  KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD 738

Query: 192  TGEDSGVGETSKRPFSHD---NADFG-KAASAGEQLELEK-----LKLTYEEKCEIEESQ 242
            + E     E + +        N D   +A    +QLE+EK      +L  ++K E  ES 
Sbjct: 739  SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798

Query: 243  LKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHM 302
             + L           E+ K+ LK     L+  T            QHE + ++  T V  
Sbjct: 799  KQKLTKQ--------EEEKQILKQDFETLSQETK----------IQHEELNNRIQTTV-- 838

Query: 303  QTIERLVKERDDLMSALVSVRSSLA---------------DTQQREASAYEQVKQVLQIS 347
              ++++  E++ LM+ L +V+  L+               + Q+ +A+  +  K   ++ 
Sbjct: 839  TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK 898

Query: 348  EEANFEKTKALIQCDQLRKELERQAE---RLEKELASQQEKRAIEKDMMKKEITKEREYM 404
             +   +    L +  +L+K LE++ E   +L+ EL S QE+    ++ +K+   +E++  
Sbjct: 899  HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ 958

Query: 405  GSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKT 464
            G+ +  L Q+  Q + Q+E +  E   A+ Q  E++++L   +  +T+   E+  +  K 
Sbjct: 959  GN-INELKQSSEQKKKQIEALQGELKIAVLQKTELENKL---QQQLTQAAQELAAEKEKI 1014

Query: 465  NMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRL 524
            ++ ++  EK    F+ +   D   ++ E+   R       Q L+  ++K +LA+E+ +  
Sbjct: 1015 SVLQNNYEKSQETFK-QLQSDFYGRESELLATR-------QDLKSVEEKLSLAQEDLISN 1066

Query: 525  TELLGESEHQLHLTRQEKDSIQQSFSK-----EAKAQALQAQQREQELTQK--------- 570
               +G     +   +  K +++Q  +K     + + +ALQ  Q+E+ L +K         
Sbjct: 1067 RNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL 1126

Query: 571  --IQQMEAQHDKTENEQYLLLTSQNTF----LTKLKEECCTLAKKLEQISQKTRSEIAQL 624
              I++++ + +K   +    L S        +T LK+    L ++  ++  K  S  A +
Sbjct: 1127 AEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAV 1186

Query: 625  SQEKRYTYDKLGKLQRRNEELEEQCVQ-HGRVHETMKQRLRQLDKHSQATAQQLVQLLSK 683
             QEKR       ++++  EEL+++ ++   ++H  +K++   + KH +  A+  +Q+ + 
Sbjct: 1187 EQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITAL 1246

Query: 684  QNQL---LLERQSLSEEVDRLRTQ 704
               L     E QS    V  L  Q
Sbjct: 1247 NENLGTVKKEWQSSQRRVSELEKQ 1270



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 165/814 (20%), Positives = 329/814 (40%), Gaps = 148/814 (18%)

Query: 18  QRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAWPELQQSHAVNQL 77
           +RSLRE A + + +LT  L + + T+ +D          G ED      EL Q   V  L
Sbjct: 182 ERSLREAAEQKVTRLTEELNK-EATVIQDLKT-ELLQRPGIEDVAVLKKELVQ---VQTL 236

Query: 78  KDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVK 137
            D +  + ++ESE      +K+   +    E T      +L     + + Y+  L+ ++K
Sbjct: 237 MDNMTLERERESEKLKDECKKLQS-QYASSEATISQLRSELAKGPQEVAVYVQELQ-KLK 294

Query: 138 FCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLRE-----------------QTLLD 180
               EL+     +   +L+ E    +L+ +  EE++ +                 Q+ L 
Sbjct: 295 SSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLS 354

Query: 181 ASG-NMHNSWITTGEDSGVGETSKRPFS-------HDNADFGKAASAGEQLELEKLKLTY 232
           AS  ++H   +   E     +  K   S       H  A+F +     E+ E   L+L  
Sbjct: 355 ASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQL-- 412

Query: 233 EEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNR---VGGLCLKCAQH 289
                  +S++  L + L E +R   +   +LK +  L +    ++   V  L LK ++ 
Sbjct: 413 -------QSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL 465

Query: 290 EAVLSQTHTN--------------------VHMQTIERLVKERDDLMSALVSVRSSLADT 329
           E  L +  TN                    +   T  +L + ++DL   L  +       
Sbjct: 466 EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI 525

Query: 330 QQREA---------SAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELA 380
           Q  EA         S  E+ ++ L    +A   +T  L Q  +    L+ Q  +L ++L 
Sbjct: 526 QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLK 585

Query: 381 SQQEKRAIEKDMMKKEITKEREYMGS---KMLILSQNIAQLEAQVEKVTKEKISAI---- 433
           +Q E     ++ +  ++ +++ ++ +   ++L L  ++ +L +Q+ + +KEK+S +    
Sbjct: 586 NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNE-SKEKVSQLDIQI 644

Query: 434 ----------------------NQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEA 471
                                 N L+  Q+ L  ++ ++ K+  ++     K   +++  
Sbjct: 645 KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHC 704

Query: 472 E------KEHREFRAKTNRDLEIKDQEIEKLR---IELDESK-QHLEQEQQKAALAREEC 521
                  KE++E      +  E  + +I+KL    +E+  SK Q L+  QQ+  L  +  
Sbjct: 705 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLE 764

Query: 522 LRLTELLGESEHQLHLTRQEK----------DSIQQSFSKEAKAQALQAQQRE------- 564
           LR TEL  + E +  +    +          +SI+Q  +K+ + + +  Q  E       
Sbjct: 765 LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETK 824

Query: 565 ---QELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEI 621
              +EL  +IQ    +  K + E+  L+T           E  T+  KL ++S   ++  
Sbjct: 825 IQHEELNNRIQTTVTELQKVKMEKEALMT-----------ELSTVKDKLSKVSDSLKNSK 873

Query: 622 AQLSQEKRYTYDKLGKLQRRNEELEEQC-VQHGRVHETMKQRLRQLDKHSQATAQQLVQL 680
           ++  +E +     +  L++  +EL+ Q  VQ     +  K+  + L+K  +A+ Q  ++L
Sbjct: 874 SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLEL 933

Query: 681 LSKQNQLLLERQSLSE---EVDRLRTQLPSMPQS 711
            S Q QL+  + +L +   E  +L+  +  + QS
Sbjct: 934 NSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967



 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 134/694 (19%), Positives = 282/694 (40%), Gaps = 103/694 (14%)

Query: 68   LQQS------HAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHT 121
            LQQS       A N L+ +LRQ  DK+ ++            ++   E     ++  +  
Sbjct: 496  LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555

Query: 122  INDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEE-----TLREQ 176
               ++  ++ L+ +    +E+++ +  K++     ++  Q+ L  Q QE+       +++
Sbjct: 556  GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615

Query: 177  TL-LDASGNMHNSWITTGED------------------SGVGETSKRPFSHDNADFGKAA 217
             L L+ S N  NS +   ++                  +   +T++R    ++ D  + A
Sbjct: 616  VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675

Query: 218  SAGEQLELEKLKLTYE----------EKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHK 267
               +Q EL K+    +          E C   ES LK  +      ++  E+L+ Q+K  
Sbjct: 676  LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735

Query: 268  EFLLAANTCNRVGGLCLKCAQHEAVLS-----QTHTNVHMQTIERLVKERDDLMSALVSV 322
            E             L +K ++ +A+       Q +T++ ++  E L K+ +     + S 
Sbjct: 736  E----------ADSLEVKASKEQALQDLQQQRQLNTDLELRATE-LSKQLEMEKEIVSST 784

Query: 323  RSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKEL--- 379
            R  L    Q+++ A E +KQ L   EE   EK       + L +E + Q E L   +   
Sbjct: 785  RLDL----QKKSEALESIKQKLTKQEE---EKQILKQDFETLSQETKIQHEELNNRIQTT 837

Query: 380  ASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEI 439
             ++ +K  +EK+ +  E++  ++    K+  +S ++   +++ EK  ++  +AI      
Sbjct: 838  VTELQKVKMEKEALMTELSTVKD----KLSKVSDSLKNSKSEFEKENQKGKAAI------ 887

Query: 440  QSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIE 499
                    +D+ K C E+++QL    ++ +   KE +E +    ++ E   Q    L++E
Sbjct: 888  --------LDLEKTCKELKHQLQ---VQMENTLKEQKELKKSLEKEKEASHQ----LKLE 932

Query: 500  LDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQ 559
            L+  ++ L Q Q       +E  +L   + E +      +++ +++Q         +   
Sbjct: 933  LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL 992

Query: 560  AQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRS 619
              + +Q+LTQ  Q++ A+ +K    Q     SQ TF            K+L+       S
Sbjct: 993  ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETF------------KQLQSDFYGRES 1040

Query: 620  EIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQ 679
            E+    Q+ +   +KL   Q        Q     ++ + +K     L++ S    QQL +
Sbjct: 1041 ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE 1100

Query: 680  LLSKQNQLLLERQSLSEEVDRLRTQLPSMPQSDC 713
                   +  E+    +E+   +++L  + +  C
Sbjct: 1101 RCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKC 1134



 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 127/581 (21%), Positives = 247/581 (42%), Gaps = 126/581 (21%)

Query: 240 ESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLL--AANTCNRVGGLCLKCAQHEAVLSQTH 297
           ES L   R+D+   ++  +DL+  LK +++          +  GL  + A+ + ++  T 
Sbjct: 75  ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLV--TD 132

Query: 298 TNVHMQTIERLVKE-----------RDDLMSALVSVRSSLADTQQR---EASAYEQVKQ- 342
           ++  +Q++E+ ++E           +D        + + +AD + +   E S  E  +Q 
Sbjct: 133 SSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQK 192

Query: 343 VLQISEEANFEKT----------------------KALIQ----CDQLRKELERQAERLE 376
           V +++EE N E T                      K L+Q     D +  E ER++E+L+
Sbjct: 193 VTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLK 252

Query: 377 ---KELASQ-------------------QEKRAIEKDMMK-----KEITKEREYMGSKML 409
              K+L SQ                   QE     +++ K      E+T++ + +   +L
Sbjct: 253 DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLL 312

Query: 410 ILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKD 469
              Q+  +LE   EK  +E +S  N    IQ+ L  +++D  ++  + R   ++T++ + 
Sbjct: 313 KKEQDYTKLE---EKHNEESVSKKN----IQATLHQKDLDCQQL--QSRLSASETSLHRI 363

Query: 470 EAE-KEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELL 528
             E  E  E   K   +L   + + + L+ E  + +Q  E+++Q     + E  +L   L
Sbjct: 364 HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423

Query: 529 GESEHQL-----HLTRQEKDSIQQSFSKEAKAQALQAQ--QREQELTQKI---QQMEAQH 578
            E+E QL      L  Q + S ++   KE +   LQ +  + E++L +K+    +++ Q 
Sbjct: 424 LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL 483

Query: 579 DKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQIS-------------QKTRSEIAQLS 625
           DKT+ +       Q +   KL+E    L + L QI              QK++  I+ L 
Sbjct: 484 DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLE 543

Query: 626 QEKRYTYDK----------LGKLQRRNEELEEQCVQ-----------HGRVHETMKQRLR 664
           +E+   Y K          L +LQ +N  L+EQ  Q           H +  E +  +++
Sbjct: 544 KEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQ 603

Query: 665 QLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
           +   H +A   +++ L +  N+L  +     E+V +L  Q+
Sbjct: 604 EQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI 644



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 114/581 (19%), Positives = 233/581 (40%), Gaps = 38/581 (6%)

Query: 22   REHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDA----RTAWPELQQSHAVNQ- 76
            +  A  SI Q     +E    + +D   LS  T + +E+     +T   ELQ+     + 
Sbjct: 791  KSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEA 850

Query: 77   LKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEV 136
            L   L    DK S+VS S +   S     E E+ N      ++       +  H L+ ++
Sbjct: 851  LMTELSTVKDKLSKVSDSLKNSKS-----EFEKENQKGKAAILDLEKTCKELKHQLQVQM 905

Query: 137  KFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDS 196
            +   +E   +K  ++     +  L+ +L S +++    + TL               E  
Sbjct: 906  ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965

Query: 197  GVGETSKRPFSHDNADFGKAASAGEQLE--LEKLKLTYEEKCEIEESQLKFLRNDLAEYQ 254
               E  K+       +   A     +LE  L++      ++   E+ ++  L+N+  + Q
Sbjct: 966  QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQ 1025

Query: 255  RTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDD 314
             T + L+     +E  L A   +      LK  + +  L+Q     +   I    K   +
Sbjct: 1026 ETFKQLQSDFYGRESELLATRQD------LKSVEEKLSLAQEDLISNRNQIGNQNKLIQE 1079

Query: 315  LMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAER 374
            L +A  ++     D+ ++E    E+ K +  I +E +  K K L+       E+E    R
Sbjct: 1080 LKTAKATLEQ---DSAKKEQQLQERCKALQDIQKEKSL-KEKELVNEKSKLAEIEEIKCR 1135

Query: 375  LEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAIN 434
             EKE+    E+    K    KEIT  ++   +K L++ Q + +L+ + + +         
Sbjct: 1136 QEKEITKLNEELKSHKLESIKEITNLKD---AKQLLIQQKL-ELQGKADSLKAAVEQEKR 1191

Query: 435  QLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIE 494
              + ++ Q+   E ++ K   E   +L+    EK+   K+H E  AK    +   ++ + 
Sbjct: 1192 NQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLG 1251

Query: 495  KLRIELDESKQHLEQEQQKAALAREE--CLRLTELLGESEHQLHLTRQEKDSIQQSFSKE 552
             ++ E   S++ + + +++    R E   L  T    + E +  L R  K    +   ++
Sbjct: 1252 TVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKG---EGEIEK 1308

Query: 553  AKAQALQAQQR-------EQELTQKIQQMEAQHDKTENEQY 586
             + + L+ Q++        QEL ++ Q ++ +H +  N ++
Sbjct: 1309 LQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKW 1349


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 145/692 (20%), Positives = 277/692 (40%), Gaps = 107/692 (15%)

Query: 108 EETNMPTMHD--LVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLK 165
           E    P + D   V T+    Q +   E  +K CKE +   K +  ++  E E LQ+QL 
Sbjct: 265 ESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLD 324

Query: 166 SQRQE-------ETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAAS 218
            + QE           +  L+    +  N      +D G+     +   H+  +  +   
Sbjct: 325 ERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEI 384

Query: 219 AGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNR 278
           A  +  ++++    EE  E +E   +    +L +   T +  +E  +     L A    +
Sbjct: 385 AQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRK----LKAEMDEQ 440

Query: 279 VGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSV-RSSLADTQQ------ 331
           +  +     +    L Q  + V  + ++ + K  ++ ++ L  +    LA  +Q      
Sbjct: 441 IKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKL 500

Query: 332 --REASAYEQVK--------QVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELAS 381
             RE    EQ+K        + L+IS+E   +++ AL + +  +K +  ++E   ++L  
Sbjct: 501 QTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDL-- 558

Query: 382 QQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIA-QLEAQVEKVTKE-------KISAI 433
           QQE       +++ E + E+    +K    S+++A  LEA+  K  KE         + +
Sbjct: 559 QQEAETYRTRILELESSLEKSLQENKN--QSKDLAVHLEAEKNKHNKEITVMVEKHKTEL 616

Query: 434 NQLEEIQSQLASREMDVTKVCGEMRYQLNKTNM-EKDEAEKEH-------------REFR 479
             L+  Q  L + ++ V K     +YQ     + EK E EKE               E  
Sbjct: 617 ESLKHQQDALWTEKLQVLK----QQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMN 672

Query: 480 AKTNRDLEIKDQEIEKLRIEL--------------------------------DESKQHL 507
            KT   L++K  E+E L  EL                                DE K H 
Sbjct: 673 EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHH 732

Query: 508 EQEQQKAALAREECLRLTE-LLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQE 566
           +Q+        E  ++ TE  L +  +QL L  +E+D   +      +      ++ E E
Sbjct: 733 QQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE 792

Query: 567 LTQKIQQME-------AQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRS 619
           L Q   +++       A H++T+  +  L   Q   L  L+ E   L K++ ++  + + 
Sbjct: 793 LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL-DLETERILLTKQVAEVEAQKKD 851

Query: 620 EIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQ 679
              +L   K    D + +L+++N E+E++     +V+E+   +L   +K  + T Q LV+
Sbjct: 852 VCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYES---KLEDGNKEQEQTKQILVE 908

Query: 680 LLSKQNQLLLERQSLSEEVDRLRTQLPSMPQS 711
              K+N +L  R+   +E++ L  +L +   S
Sbjct: 909 ---KENMILQMREGQKKEIEILTQKLSAKEDS 937



 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 157/763 (20%), Positives = 321/763 (42%), Gaps = 94/763 (12%)

Query: 1    MAKSPENSTLE--EILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGN 58
            + K  EN+ LE  +   Q+   + E A  +   ++ A+   +    E   +L+       
Sbjct: 981  LKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRREL 1040

Query: 59   EDARTAWPEL--QQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMP--- 113
             D  + W +   QQ+  + ++ ++  Q  +KE EV+  +++ +  L   E EE N     
Sbjct: 1041 NDVISIWEKKLNQQAEELQEIHEI--QLQEKEQEVAELKQKIL--LFGCEKEEMNKEITW 1096

Query: 114  ----------TMHDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQ 163
                      T+++L   +  +S +++ L  +    K  L  ++  +   + EN  LQ+Q
Sbjct: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQ 1156

Query: 164  LKSQRQ--EETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGE 221
            L   +   EE  R+ + L +     +    + + S   E S +     + +F K +    
Sbjct: 1157 LVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH--EKSNKSLEDKSLEFKKLS---- 1210

Query: 222  QLELEKLKLTYEEKCEIEESQLKFLRNDL---------AEYQRTCEDLKEQLKHKEFLLA 272
                E+L +  +  C+  E+ L+   N+L         A   R         K KE LL 
Sbjct: 1211 ----EELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLI 1266

Query: 273  ANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQ- 331
              TC       L+    +    Q   N+  Q     ++E+++ + ++ +   SL   ++ 
Sbjct: 1267 -KTCTVSE---LEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322

Query: 332  -------REASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELA--SQ 382
                   ++ +A E+   + Q+ +E + E   A+    +  KE + +   L K+L   + 
Sbjct: 1323 LQKEGGNQQQAASEKESCITQLKKELS-ENINAVTLMKEELKEKKVEISSLSKQLTDLNV 1381

Query: 383  QEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQ 442
            Q + +I     +  I+  R+    +   L   +  L  +V+ ++KEKISA+ Q+++    
Sbjct: 1382 QLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDD---- 1437

Query: 443  LASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDE 502
              S +    K   + R+  ++  +++ + + E +      +++   KD++I  L+ ELD+
Sbjct: 1438 -WSNKFSEWKKKAQSRFTQHQNTVKELQIQLELK------SKEAYEKDEQINLLKEELDQ 1490

Query: 503  SKQHL-----EQEQQKAALAREECLRLTELLGES----EHQLHLTRQEKDSIQQSFSKEA 553
              +       E E  K+ + ++E    TEL  ++    E + H+T  +K    +S ++  
Sbjct: 1491 QNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT--QKTIEIESLNEVL 1548

Query: 554  KAQALQAQQREQELTQKIQQM----EAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKK 609
            K    Q     +EL QK+Q      E + ++ +  +  +LT +N  +  +K E  T  K+
Sbjct: 1549 KNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQ-VYSMKAELETKKKE 1607

Query: 610  LEQISQKTRSEIAQL-SQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDK 668
            LE ++   +S+  +L + E R   +   KL     + E+      ++    KQ L Q+++
Sbjct: 1608 LEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ------KIAAIKKQLLSQMEE 1661

Query: 669  HSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQS 711
              +   +     LS+ N  L ER+    EV  L  +L S+  S
Sbjct: 1662 KEEQYKKGTESHLSELNTKLQERE---REVHILEEKLKSVESS 1701



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 135/657 (20%), Positives = 269/657 (40%), Gaps = 116/657 (17%)

Query: 67   ELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHE-ETNMPTMHDL-VHTIND 124
            ELQ+   + + ++ LR   D + E    R R +    SLE   + N     DL VH   +
Sbjct: 541  ELQKKAILTESENKLR---DLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAE 597

Query: 125  QSQYIHHLEAEVKFCKEELSGMKNKIQVVVLEN-EGLQQQLKSQRQEETLREQTLLDASG 183
            ++++   +   V+  K EL  +K++   +  E  + L+QQ   Q + E LRE+       
Sbjct: 598  KNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQY--QTEMEKLREKC------ 649

Query: 184  NMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQL 243
                            E  K     D     +A        +E++     EK ++++++L
Sbjct: 650  ----------------EQEKETLLKDKEIIFQA-------HIEEMNEKTLEKLDVKQTEL 686

Query: 244  KFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQ 303
            + L ++L+E  +    L+E+L     +L   T         K  Q          N H Q
Sbjct: 687  ESLSSELSEVLKARHKLEEELS----VLKDQTD--------KMKQELEAKMDEQKNHHQQ 734

Query: 304  TIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQ 363
             ++ ++KE +      VS+       Q+ E +  +Q+ Q+  + +E    + K L +   
Sbjct: 735  QVDSIIKEHE------VSI-------QRTEKALKDQINQLELLLKE----RDKHLKEHQA 777

Query: 364  LRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVE 423
              + LE   +R E EL     K  + +        + + Y         + +AQL+ ++ 
Sbjct: 778  HVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAY--------EEQLAQLQQKLL 829

Query: 424  KVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTN 483
             +  E+I    Q+ E+++Q          VC E+     +      + EK++ E   K  
Sbjct: 830  DLETERILLTKQVAEVEAQKKD-------VCTELDAHKIQVQDLMQQLEKQNSEMEQKVK 882

Query: 484  RDLEIKDQEIEKLRIELDESKQHLEQEQQKAALARE----ECLRLTELLGESEHQLHLTR 539
               ++ + ++E    E +++KQ L +++      RE    E   LT+ L   E  +H+  
Sbjct: 883  SLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILN 942

Query: 540  QEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDK-TENEQYLLLTSQNTFLTK 598
            +E ++  ++  K+ +    +A++ ++ L +K+   EA+  K  EN    L   +  F  K
Sbjct: 943  EEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAK 1002

Query: 599  LKE----ECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKL-----GKLQRRNEELEEQC 649
            + E        ++  + ++    + +I  L++  R   + +      KL ++ EEL+E  
Sbjct: 1003 MLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQE-- 1060

Query: 650  VQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLL--ERQSLSEEVDRLRTQ 704
                 +HE       QL +  Q  A+       KQ  LL   E++ +++E+  L+ +
Sbjct: 1061 -----IHEI------QLQEKEQEVAE------LKQKILLFGCEKEEMNKEITWLKEE 1100



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 86/417 (20%), Positives = 181/417 (43%), Gaps = 50/417 (11%)

Query: 301 HMQT-IERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEAN-FEKTK-- 356
           H+Q   +  ++E+D  +S L +  S L    +      + +K + Q+  +A  F K +  
Sbjct: 205 HLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENP 264

Query: 357 -----ALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKE----ITKEREYMGSK 407
                 +++     K LE   +R++++      KR  E     KE    +T E+E +  +
Sbjct: 265 ESDGEPVVEDGTSVKTLETLQQRVKRQ--ENLLKRCKETIQSHKEQCTLLTSEKEALQEQ 322

Query: 408 MLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNME 467
              L + + +LE   +    EK   I QL + ++ +   E D   V  E + Q+++T   
Sbjct: 323 ---LDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHET--- 376

Query: 468 KDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDE----SKQHLEQEQQKAALAREECLR 523
                             LE+K++EI +LR  + +     ++  EQ+++    A EE  +
Sbjct: 377 ------------------LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEK 418

Query: 524 LTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTEN 583
                 ++E      + E D   ++  K ++ + +  QQ   EL++  Q++     K+  
Sbjct: 419 ALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQ---ELSRVKQEVVDVMKKSSE 475

Query: 584 EQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLG--KLQRR 641
           EQ   L   +      KE+   L KKL+   ++ + ++    ++ +  Y K+   K Q+ 
Sbjct: 476 EQIAKLQKLHEKELARKEQ--ELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQE 533

Query: 642 NEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEV 698
           +  LEE  +Q   +    + +LR L + ++    ++++L S   + L E ++ S+++
Sbjct: 534 SLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDL 590



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 102/518 (19%), Positives = 213/518 (41%), Gaps = 83/518 (16%)

Query: 126  SQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNM 185
            SQ     E   K  +  LS +  K+Q    E   L+++LKS    E+ + +TL+      
Sbjct: 1657 SQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSV---ESSQSETLIVPRSAK 1713

Query: 186  HNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQL-------ELEKLKLTYEEKCEI 238
            + +  T  E++      ++ +    +   +  +  E+L       + E +   +E +C+ 
Sbjct: 1714 NVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY 1773

Query: 239  EESQLKFLRNDLAEYQRTC------EDLKEQLKHKEFLLAANTCNRVGGLCLKCAQH-EA 291
            +E  +K    +  +++         E+L+E+ K    ++A +     G   ++  Q+ E 
Sbjct: 1774 QERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLEN 1833

Query: 292  VLSQTHTNVH-----MQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQI 346
            V       +       Q +E+ +KE D   S LV  +       +   S YE+++ + Q+
Sbjct: 1834 VFDDVQKTLQEKELTCQILEQKIKELD---SCLVRQKEVHRVEMEELTSKYEKLQALQQM 1890

Query: 347  S---------EEANFEKTKA---------------------LIQCDQLRKELERQAERLE 376
                      EE   EK+K+                     L   ++ +++L ++  RL+
Sbjct: 1891 DGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQ 1950

Query: 377  KELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQL 436
            K+L   +++   E +++KKE  +ERE              +++ + E +  +  S + QL
Sbjct: 1951 KDLRMLRKEHQQELEILKKEYDQERE-------------EKIKQEQEDLELKHNSTLKQL 1997

Query: 437  -EEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEK 495
              E  +QLA +E ++     E    +NK    + E  + H+E   +  + +  KD ++++
Sbjct: 1998 MREFNTQLAQKEQELEMTIKE---TINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKR 2054

Query: 496  LRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKA 555
                 +E      +E++  A  R+   +L EL  + ++Q  L ++E          E + 
Sbjct: 2055 TAKRYEEILD--AREEEMTAKVRDLQTQLEEL--QKKYQQKLEQEENPGNDNVTIMELQT 2110

Query: 556  QALQ-------AQQREQELTQKIQQMEAQHDKTENEQY 586
            Q  Q       ++ +EQE  ++I  +E +  K E   Y
Sbjct: 2111 QLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVY 2148


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 137/674 (20%), Positives = 276/674 (40%), Gaps = 80/674 (11%)

Query: 74   VNQLKDLLRQQAD---KESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIH 130
            V  L  + RQ+ +   K+ E+   + ++      LE  E     + +  + + +Q Q   
Sbjct: 841  VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET 900

Query: 131  HLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNM--HNS 188
             L AE +  +  L+  K +++ ++         L+S+ +EE  R Q L +    M  H  
Sbjct: 901  ELFAEAEEMRARLAAKKQELEEIL-------HDLESRVEEEEERNQILQNEKKKMQAHIQ 953

Query: 189  WITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKFLRN 248
             +    D   G   K       A+        E L LE     + ++ ++ E ++    +
Sbjct: 954  DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSS 1013

Query: 249  DLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIER- 307
             LAE +   ++L + +++K+ ++ ++               E +  +  T   ++  +R 
Sbjct: 1014 QLAEEEEKAKNLAK-IRNKQEVMISDL-------------EERLKKEEKTRQELEKAKRK 1059

Query: 308  LVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKE 367
            L  E  DL   +  +++ + + + + A   E+++  L   ++    K  AL    +L+ +
Sbjct: 1060 LDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQ 1119

Query: 368  LERQAERLEKELAS----QQEKRAIEKDM--MKKEI--------------TKEREYMGSK 407
            +    E  E E AS    +++KR + +++  +K E+              TK  + +   
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL 1179

Query: 408  MLILSQNIAQLEAQVEKVTKEKISAINQLEE-------IQSQLASREMDVTKVCGEMRYQ 460
               L +     EAQ++ + +   +A+ +L E        ++ L   +  +     E+  +
Sbjct: 1180 KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1239

Query: 461  LNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREE 520
            +      K E+E + ++  A+  ++L  K  E ++LR+EL E    L+ E    +   EE
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQV-QELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE 1298

Query: 521  CLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDK 580
              +      +    L    Q+   + Q  +++    + + +Q E+E     +Q E + + 
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358

Query: 581  TEN--EQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQ---EKRYTYDKL 635
             +N  +Q L L SQ     K  ++     + LE+  +K   +   LSQ   EK   YDKL
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1418

Query: 636  GKLQRR-NEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSL 694
             K + R  +EL++  V               LD H +  A  L +   K +QLL E +S+
Sbjct: 1419 EKTKNRLQQELDDLTV--------------DLD-HQRQVASNLEKKQKKFDQLLAEEKSI 1463

Query: 695  S----EEVDRLRTQ 704
            S    EE DR   +
Sbjct: 1464 SARYAEERDRAEAE 1477



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 121/543 (22%), Positives = 219/543 (40%), Gaps = 93/543 (17%)

Query: 215  KAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAAN 274
            +A  A ++ ELE++    E + E EE + + L+N+  + Q   +DL+EQL  +E      
Sbjct: 910  RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG----- 964

Query: 275  TCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREA 334
                        A+ +  L +      ++ +E  +   +D  S  +  +  + D     +
Sbjct: 965  ------------ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012

Query: 335  SAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMK 394
            S         Q++EE   EK K L +   +R + E     LE+ L  +++ R        
Sbjct: 1013 S---------QLAEEE--EKAKNLAK---IRNKQEVMISDLEERLKKEEKTR-------- 1050

Query: 395  KEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLAS------REM 448
            +E+ K +  +  +   L   IA+L+AQ++++   K+    + EE+Q  LA        + 
Sbjct: 1051 QELEKAKRKLDGETTDLQDQIAELQAQIDEL---KLQLAKKEEELQGALARGDDETLHKN 1107

Query: 449  DVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLE 508
            +  KV  E++ Q+ +   E  E+EK  R    K  RDL    +E+E L+ EL+++     
Sbjct: 1108 NALKVVRELQAQIAELQ-EDFESEKASRNKAEKQKRDLS---EELEALKTELEDTLDTTA 1163

Query: 509  QEQQKAALAREECLRLTELLGESE----------HQLHLTRQEKDSIQQSFSKEAKA--- 555
             +Q+      +E   L + L E             Q H T  E+ S Q   +K  KA   
Sbjct: 1164 AQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE 1223

Query: 556  ---QALQAQQREQELTQKIQQM---EAQH-----DKTENEQYLLLTSQNTFLTKLKEECC 604
               Q L+   +E     K+ Q    E++H     D    E +  ++  +    +L E+  
Sbjct: 1224 KNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS 1283

Query: 605  TLAKKLEQISQ----------KTRSEIAQLSQEKRYTYDKLGK-------LQRRNEELEE 647
             L  +L+ +S           K   + A L  + + T + L +       L  R  +LEE
Sbjct: 1284 KLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEE 1343

Query: 648  QCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPS 707
            +        E  ++  + L+K   A   QL     K +  L   +SL E   +L     +
Sbjct: 1344 EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA 1403

Query: 708  MPQ 710
            + Q
Sbjct: 1404 LSQ 1406



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 128/674 (18%), Positives = 286/674 (42%), Gaps = 77/674 (11%)

Query: 76   QLKDLLRQQADKESEVSPSRRR-------KMSPLRSLEHEETNMPTMHDLVHTINDQSQY 128
            Q+ +L  Q A KE E+  +  R       K + L+ +   +  +    +L      +   
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIA---ELQEDFESEKAS 1133

Query: 129  IHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNS 188
             +  E + +   EEL  +K +++   L+    QQ+L+++R++E    +  L+     H +
Sbjct: 1134 RNKAEKQKRDLSEELEALKTELEDT-LDTTAAQQELRTKREQEVAELKKALEEETKNHEA 1192

Query: 189  WI--------TTGEDSGVG-----------ETSKRPFSHDNADFGKAASAGEQLELEKLK 229
             I        T  E+               E +K+    DN +        +Q++ E   
Sbjct: 1193 QIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEH 1252

Query: 230  LTYEEKCEIEESQLKFLRNDL--AEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCA 287
               +   +++E   K    D    E       L+ +L +   LL       +       A
Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIK-FAKDAA 1311

Query: 288  QHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQV-KQVLQI 346
              E+ L  T   +  +T ++L       +  L   ++SL + Q+ E  A + + KQVL +
Sbjct: 1312 SLESQLQDTQELLQEETRQKL--NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLAL 1369

Query: 347  SEEANFEKTKA------LIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKE 400
              +    K K       +   ++ +K+L + AE L + L    E++A+  D ++K   + 
Sbjct: 1370 QSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL----EEKALAYDKLEKTKNRL 1425

Query: 401  REYMGSKMLILSQNIAQLEAQVEKVTKE---------KISAINQLEEIQSQLASREMDVT 451
            ++ +    + L     Q+ + +EK  K+          ISA    E  +++  +RE + T
Sbjct: 1426 QQELDDLTVDLDHQ-RQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKE-T 1483

Query: 452  KVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQ 511
            K     R  L +    K+E E+++++ RA     +  KD ++ K   EL++SK+ LEQ+ 
Sbjct: 1484 KALSLAR-ALEEALEAKEEFERQNKQLRADMEDLMSSKD-DVGKNVHELEKSKRALEQQV 1541

Query: 512  QKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKI 571
            ++     EE     +   +++ +L +  Q   +++  F ++ + +  Q +++++ L +++
Sbjct: 1542 EEMRTQLEELEDELQATEDAKLRLEVNMQ---AMKAQFERDLQTRDEQNEEKKRLLIKQV 1598

Query: 572  QQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYT 631
            +++EA+ +    ++ L + S+      LK+    L  ++E  + K R E+ +        
Sbjct: 1599 RELEAELEDERKQRALAVASKKKMEIDLKD----LEAQIEA-ANKARDEVIK-------- 1645

Query: 632  YDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLER 691
              +L KLQ + ++ + +  +     + +  + ++ +K  ++   +++QL  +       R
Sbjct: 1646 --QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERAR 1703

Query: 692  QSLSEEVDRLRTQL 705
            +   +E D L  ++
Sbjct: 1704 RHAEQERDELADEI 1717



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 131/710 (18%), Positives = 306/710 (43%), Gaps = 82/710 (11%)

Query: 67   ELQQSHA-VNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQ 125
            E+++ H  + + K++L +Q   E+E+        + L + + E   +  +HDL   + ++
Sbjct: 877  EMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEI--LHDLESRVEEE 934

Query: 126  SQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQR-----QEETLREQTLLD 180
             +    L+ E K  +  +  ++ ++     E EG +Q+L+ ++     + + + E+ LL 
Sbjct: 935  EERNQILQNEKKKMQAHIQDLEEQLD----EEEGARQKLQLEKVTAEAKIKKMEEEILLL 990

Query: 181  ASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLEL-----EKLKLTYEEK 235
               N          +  + E S +    +      A    +Q  +     E+LK   + +
Sbjct: 991  EDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR 1050

Query: 236  CEIEESQLKF------LRNDLAEYQRTCEDLKEQLKHKEFLLAA-------NTCNRVGGL 282
             E+E+++ K       L++ +AE Q   ++LK QL  KE  L          T ++   L
Sbjct: 1051 QELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL 1110

Query: 283  CLKCAQHEAVLSQTHTNVHMQTIER--LVKERDDLMSALVSVRSSLADTQQREASAYE-- 338
             +   + +A +++   +   +   R    K++ DL   L ++++ L DT    A+  E  
Sbjct: 1111 KV-VRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELR 1169

Query: 339  --QVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRA-IEKDMMKK 395
              + ++V ++ +    E      Q   +R+      E L ++L   +  +A +EK+  K+
Sbjct: 1170 TKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKN--KQ 1227

Query: 396  EITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCG 455
             +  + + +  ++ +L Q    ++A+ E   K+  + + +L    S+     +++ +   
Sbjct: 1228 GLETDNKELACEVKVLQQ----VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS 1283

Query: 456  EMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIE--------------LD 501
            +++ +L+  +   +EAEK+  +F AK    LE + Q+ ++L  E              L+
Sbjct: 1284 KLQNELDNVSTLLEEAEKKGIKF-AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLE 1342

Query: 502  ESKQHLEQEQQKAALARE----ECLRLTELLGESEHQLHLTRQEKDSIQQSFSK-----E 552
            E K  L+++Q++   AR+    + L L   L +++ ++       +S++++  K     E
Sbjct: 1343 EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE 1402

Query: 553  AKAQALQA--------QQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECC 604
            A +Q L+         ++ +  L Q++  +    D        L   Q  F   L EE  
Sbjct: 1403 ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS 1462

Query: 605  TLAK------KLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHET 658
              A+      + E  +++  ++   L++      +   + +R+N++L           + 
Sbjct: 1463 ISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDD 1522

Query: 659  MKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSM 708
            + + + +L+K  +A  QQ+ ++ ++  +L  E Q+  +   RL   + +M
Sbjct: 1523 VGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAM 1572



 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 147/741 (19%), Positives = 287/741 (38%), Gaps = 110/741 (14%)

Query: 6    ENSTLEEILGQYQRSLREHASRSIHQLTCALKEGD---VTIGEDAPNLSFSTSVGNEDAR 62
            E   L+++  + +   R+     + +L   + EGD   V + E A  L     + N    
Sbjct: 1239 EVKVLQQVKAESEHK-RKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ--NELDNVSTL 1295

Query: 63   TAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKM---SPLRSLEHEETNMPTMHDLV 119
                E +          L  Q  D +  +    R+K+   S +R LE E+ ++    +  
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE-- 1353

Query: 120  HTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLK---------SQRQE 170
                ++ +   +LE +V   + +L+  K K+   +   E L++  K         SQR E
Sbjct: 1354 ----EEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE 1409

Query: 171  ETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKL 230
            E       L+ + N     +   +D  V    +R  +   ++  K     +QL  E+  +
Sbjct: 1410 EKALAYDKLEKTKNRLQQEL---DDLTVDLDHQRQVA---SNLEKKQKKFDQLLAEEKSI 1463

Query: 231  T--YEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQ 288
            +  Y E+ +  E++ +          R    L+E L+ KE     N   R     L  ++
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARA---LEEALEAKEEFERQNKQLRADMEDLMSSK 1520

Query: 289  -------HEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVK 341
                   HE   S+      ++ +   ++E +D + A    +  L    Q   + +E+  
Sbjct: 1521 DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERD- 1579

Query: 342  QVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKER 401
              LQ  +E N EK + LI          +Q   LE EL  ++++RA+     KK      
Sbjct: 1580 --LQTRDEQNEEKKRLLI----------KQVRELEAELEDERKQRALAVASKKK------ 1621

Query: 402  EYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLAS--REMDVTKVCGEMRY 459
                     +  ++  LEAQ+E   K +   I QL ++Q+Q+    RE++  +   +  +
Sbjct: 1622 ---------MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIF 1672

Query: 460  QLNKTN-------------MEKDEAEKEHREFRAKTNRDLEIKDQ-------------EI 493
              +K +             ++++ A  E     A+  RD E+ D+             E 
Sbjct: 1673 AQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD-ELADEITNSASGKSALLDEK 1731

Query: 494  EKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTR---QEKDSIQQSFS 550
             +L   + + ++ LE+EQ    L  +   + T  +     +L   R   Q+ D+ +Q   
Sbjct: 1732 RRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLE 1791

Query: 551  KEAKAQALQAQQREQELTQK----IQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTL 606
            ++ K    + Q+ E  +  K    I  +EA+  + E EQ      +     KL       
Sbjct: 1792 RQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE-EQLEQEAKERAAANKLVRRT--- 1847

Query: 607  AKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQL 666
             KKL++I  +   E     Q K        ++++   +LEE   +  R + + ++  R+L
Sbjct: 1848 EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQREL 1907

Query: 667  DKHSQATAQQLVQLLSKQNQL 687
            D  ++A      ++ + +N+L
Sbjct: 1908 DDATEANEGLSREVSTLKNRL 1928



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 93/496 (18%), Positives = 203/496 (40%), Gaps = 71/496 (14%)

Query: 115  MHDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQ----------QQL 164
            M DL+ + +D  + +H LE   +  ++++  M+ +++ +  E +  +          Q +
Sbjct: 1513 MEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAM 1572

Query: 165  KSQ--RQEETLREQT------LLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKA 216
            K+Q  R  +T  EQ       L+     +        +   +   SK+    D  D    
Sbjct: 1573 KAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQ 1632

Query: 217  ASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTC 276
              A  +   E +K            QL+ L+  + +YQR  E+ +   + + F  +  + 
Sbjct: 1633 IEAANKARDEVIK------------QLRKLQAQMKDYQRELEEARAS-RDEIFAQSKESE 1679

Query: 277  NRVGGLCLKCAQ-HEAVLSQTHTNVHMQTIERLVKERDDLMSALV---SVRSSLADTQQR 332
             ++  L  +  Q  E + S      H +      +ERD+L   +    S +S+L D ++R
Sbjct: 1680 KKLKSLEAEILQLQEELASSERARRHAE------QERDELADEITNSASGKSALLDEKRR 1733

Query: 333  EASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDM 392
              +      ++ Q+ EE   E++   +  D+ RK    Q + L  ELA+++   A + D 
Sbjct: 1734 LEA------RIAQLEEELEEEQSNMELLNDRFRKTT-LQVDTLNAELAAERSA-AQKSDN 1785

Query: 393  MKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISA----INQLEEIQSQLASREM 448
             ++++ ++ + + +K+        +LE  V+   K  ISA    I QLEE   Q A    
Sbjct: 1786 ARQQLERQNKELKAKL-------QELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERA 1838

Query: 449  DVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLE 508
               K+      +L +  M+ ++  +   +++           +++EK    + + K+ LE
Sbjct: 1839 AANKLVRRTEKKLKEIFMQVEDERRHADQYK-----------EQMEKANARMKQLKRQLE 1887

Query: 509  QEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELT 568
            + +++A  A     +L   L ++        +E  +++    +        ++   ++L 
Sbjct: 1888 EAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLH 1947

Query: 569  QKIQQMEAQHDKTENE 584
             +   +E   D TE++
Sbjct: 1948 LEGASLELSDDDTESK 1963



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 76/385 (19%), Positives = 163/385 (42%), Gaps = 49/385 (12%)

Query: 352  FEKTKALIQCDQLRKELERQAERLEK-------------ELASQQEKRAIEKDMMKKEIT 398
            F K K L+Q  +  +EL+ + E L K             E+  + ++   EK+++ +++ 
Sbjct: 838  FTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ 897

Query: 399  KEREY----------MGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREM 448
             E E           + +K   L + +  LE++VE+  +      N+ +++Q+ +   E 
Sbjct: 898  AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957

Query: 449  DVTKVCG-EMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHL 507
             + +  G   + QL K   E    + E      +      IK++++ + RI   E    L
Sbjct: 958  QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIA--ECSSQL 1015

Query: 508  EQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQEL 567
             +E++KA    +   +   ++ + E +L    + +  ++++  ++   +    Q +  EL
Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKA-KRKLDGETTDLQDQIAEL 1074

Query: 568  TQKIQQMEAQHDKTENE-QYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQ 626
              +I +++ Q  K E E Q  L    +  L K             ++ ++ +++IA+L +
Sbjct: 1075 QAQIDELKLQLAKKEEELQGALARGDDETLHK---------NNALKVVRELQAQIAELQE 1125

Query: 627  EKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQ 686
            +         K +++  +L E+        E +K  L   D      AQQ  +L +K+ Q
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEEL-------EALKTELE--DTLDTTAAQQ--ELRTKREQ 1174

Query: 687  LLLE-RQSLSEEVDRLRTQLPSMPQ 710
             + E +++L EE      Q+  M Q
Sbjct: 1175 EVAELKKALEEETKNHEAQIQDMRQ 1199


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 86/414 (20%), Positives = 196/414 (47%), Gaps = 31/414 (7%)

Query: 310  KERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFE---KTKALIQCDQLRK 366
            KE   +       +  LA ++ R     E++  +LQ   +   +   +T+ L+  ++  +
Sbjct: 851  KEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCE 910

Query: 367  ELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVT 426
             L +    LE ++    E+   E++M  + + K+R  +  K   L ++I  LE  + KV 
Sbjct: 911  GLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRN-LEDKCSSLKRDIDDLELTLTKVE 969

Query: 427  KEKISAINQLEEIQSQLASREMDVTKVCGEMR--YQLNKTNMEKDEAEKEHREFRAKTNR 484
            KEK +  N+++ +  ++ + E +++K+  E +   + ++  ++  + E++      K N 
Sbjct: 970  KEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINA 1029

Query: 485  DLEIKDQEIE-------KLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHL 537
             LE +  ++E       KLR +L+ +K+ LE + +   +++E  + L     + E +L  
Sbjct: 1030 KLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLK---MSQESIMDLENDKQQIEEKLKK 1086

Query: 538  TRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLT 597
               E   +Q     E +  +LQ Q++ +EL  +I+++E +           + +++T   
Sbjct: 1087 KEFELSQLQAKIDDE-QVHSLQFQKKIKELQARIEELEEE-----------IEAEHTLRA 1134

Query: 598  KLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHE 657
            K++++   LA++LE+IS++        S +      +  + Q+   +LEE  +QH     
Sbjct: 1135 KIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1194

Query: 658  TMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQS 711
            T+  R +Q D  ++   +Q+  L   + +L  E+  L  E+D + + + ++ +S
Sbjct: 1195 TL--RKKQADSVAE-LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKS 1245



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 143/730 (19%), Positives = 303/730 (41%), Gaps = 117/730 (16%)

Query: 74   VNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLE 133
            V +L + L ++ +  SE+   +R       SL+ +      + DL  T+    +  H  E
Sbjct: 923  VKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRD------IDDLELTLTKVEKEKHATE 976

Query: 134  AEVKFCKEELSGMKNKIQVVVLENEGLQ---QQLKSQRQEETLREQTLLDASGNMHNSWI 190
             +VK   EE++ ++  I  +  E + LQ   QQ     Q E  +   L+  +  +     
Sbjct: 977  NKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQ-- 1034

Query: 191  TTGEDSGVGETSKRPFSHDNADFGKAA---------SAGEQLELEKLKLTYEEKC---EI 238
             T +  G  E  K+      AD  +A          S    ++LE  K   EEK    E 
Sbjct: 1035 -TDDLEGSLEQEKKL----RADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEF 1089

Query: 239  EESQLKFLRND-----------LAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCA 287
            E SQL+   +D           + E Q   E+L+E+++  E  L A    +   L  +  
Sbjct: 1090 ELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIE-AEHTLRAKIEKQRSDLARELE 1148

Query: 288  QHEAVLSQ----THTNVHMQTIER--LVKERDDLMSALVSVRSSLADTQQREASAY---- 337
            +    L +    T   + M         K R DL  A +   ++ A  ++++A +     
Sbjct: 1149 EISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELG 1208

Query: 338  EQVKQVLQISEEANFEKTKALIQCDQLRKELERQAE---------RLEKELASQQEKRAI 388
            EQ+  + ++ ++   EK++  ++ D +   +E  ++         R  ++  S+ + +  
Sbjct: 1209 EQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDE 1268

Query: 389  EKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREM 448
            ++  +  ++  ++  + ++   LS  + + E+ + ++TK K +   QLEE++ Q+     
Sbjct: 1269 QQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQME---- 1324

Query: 449  DVTKVCGEMRYQLNKTNMEKD---EAEKEHREFRAKTNRDLEIKDQEIEKLRI------- 498
            + TK    M + L  +  + D   E  +E +E +A+  R L   + E+ + R        
Sbjct: 1325 EETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAI 1384

Query: 499  ----ELDESK----QHLEQEQQKAALAREECLRLTE----LLGESE------HQLHLTRQ 540
                EL+E+K    Q L++ ++    A  +C  L +    L GE E       + H    
Sbjct: 1385 QRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACA 1444

Query: 541  EKDSIQQSFSK----------EAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLT 590
              D  Q++F K          E++A+   AQ+  + L+ ++ +M   +++  ++   L  
Sbjct: 1445 TLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRR 1504

Query: 591  SQNTF---LTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKL-GKLQRRNEELE 646
                    ++ L E+     K L++ ++KT+  + Q   + +   +++ G L+    ++ 
Sbjct: 1505 ENKNLQEEISDLTEQIAETGKNLQE-AEKTKKLVEQEKSDLQVALEEVEGSLEHEESKIL 1563

Query: 647  EQCVQHGRVHETMKQR-------LRQLDKHSQATAQQLVQLLS----KQNQLLLERQSLS 695
               ++  +V   + ++       + QL ++SQ  A+ L  +L      +N  L  ++ + 
Sbjct: 1564 RVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKME 1623

Query: 696  EEVDRLRTQL 705
             +++ +  QL
Sbjct: 1624 GDLNEMEIQL 1633



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 133/691 (19%), Positives = 291/691 (42%), Gaps = 95/691 (13%)

Query: 84   QADKESEVSPSRRRKMSPLRSLEHEET-------NMPTMHDLVHTINDQSQYIHHLEAEV 136
            + +K+ E    + R+     +L+HE T          ++ +L   I++  +    LE E 
Sbjct: 1166 EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEK 1225

Query: 137  KFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETL-----REQTLLDASGNMHNSWIT 191
               K E+  M + I+ +      +++  ++   + +       +QT L    NM  + + 
Sbjct: 1226 SELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQ 1285

Query: 192  TGEDSGVGETSKRPFSHDN--ADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKFLRND 249
            T      GE S R    ++  +   K+  A  Q +LE+LK   EE+ + + +    L++ 
Sbjct: 1286 TQN----GELSHRVEEKESLISQLTKSKQALTQ-QLEELKRQMEEETKAKNAMAHALQSS 1340

Query: 250  LAEYQRTCEDLKEQLKHK-----EFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQT 304
                +  C+ L+EQ + +     E   A +  N          + +A+          + 
Sbjct: 1341 ----RHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1396

Query: 305  IERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQL 364
            + + ++E ++      S  +SL  T+QR     E + + L+ S  A     K     D++
Sbjct: 1397 LAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKV 1456

Query: 365  RKELERQAERLEKEL-ASQQEKRAIEKDMMK-----KEITKEREYMGSKMLILSQNIAQL 418
              E +++ +  + EL A+Q+E R++  ++ K     +E+  + E +  +   L + I+ L
Sbjct: 1457 LAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDL 1516

Query: 419  EAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREF 478
              Q+ +  K    A    + ++ + +  ++ + +V G + ++ +K        + E  + 
Sbjct: 1517 TEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKIL----RVQLELSQV 1572

Query: 479  RAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTEL----------- 527
            +++ +R +  KD+EIE+L+     + + L+        +R + LRL +            
Sbjct: 1573 KSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQ 1632

Query: 528  LGESEHQLHLTRQEKDSIQQSF-------------SKEAKAQALQAQQREQELTQKIQQM 574
            LG S  Q+  T++   ++Q                +++ K Q    ++R   L +++++M
Sbjct: 1633 LGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEM 1692

Query: 575  EAQHDKTENEQYL-------------LLTSQNTFLTKLK--------------EECCTLA 607
            +   ++TE  + L             LL SQNT L   K              E     +
Sbjct: 1693 KVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQES 1752

Query: 608  KKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEE--QCVQHGRVHETMKQRLRQ 665
            +  E+ ++K  ++ A +++E +   D    L+R  + LE+  + +QH R+ E  +  L+ 
Sbjct: 1753 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH-RLDEAEQLALKG 1811

Query: 666  LDKHSQATAQQLVQLLSKQNQLLLERQSLSE 696
              K  Q    ++ +L   +N+L +E++  +E
Sbjct: 1812 GKKQIQKLENRVREL---ENELDVEQKRGAE 1839



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 137/694 (19%), Positives = 286/694 (41%), Gaps = 101/694 (14%)

Query: 81   LRQQADKESEVSPSRRRKMSPLRS-LEHEETNMPTMHDLVHTINDQSQYIHHLEAEVKFC 139
            L+ + D E   S   ++K+  L++ +E  E  +   H L   I  Q   +     E+   
Sbjct: 1094 LQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISER 1153

Query: 140  KEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVG 199
             EE SG  +    +  + E   Q+++   +E TL+ +                       
Sbjct: 1154 LEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA--------------------TA 1193

Query: 200  ETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEE--SQLKFLRNDLAEYQRTC 257
             T ++  +   A+ G+     ++++ +  K   E K EI++  S ++ L    +  +RTC
Sbjct: 1194 ATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTC 1253

Query: 258  EDLKEQ-------------LKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQT 304
              +++Q             L H   +  A    + G L  +  + E+++SQ   +   Q 
Sbjct: 1254 RTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKS--KQA 1311

Query: 305  IERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCD-- 362
            + + ++E    M      ++++A   Q      + +++  +  +EA  E  +AL + +  
Sbjct: 1312 LTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSE 1371

Query: 363  --QLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEA 420
              Q R + E  A +  +EL   ++K A       +E  +  E   SK   L +   +L+ 
Sbjct: 1372 VAQWRTKYETDAIQRTEELEEAKKKLA----QRLQEAEENTETANSKCASLEKTKQRLQG 1427

Query: 421  QVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRA 480
            +VE + ++    + +     + L  ++ +  KV  E + +L+++  E + A+KE R    
Sbjct: 1428 EVEDLMRD----LERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLST 1483

Query: 481  KT----NRDLEIKDQ-------------EIEKLRIELDESKQHLEQEQQKAALAREEC-- 521
            +     N   E+ DQ             EI  L  ++ E+ ++L++ ++   L  +E   
Sbjct: 1484 ELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSD 1543

Query: 522  --LRLTELLGESEH--------QLHLTRQEKDSIQQSFSKEAKAQALQAQ-QREQELTQK 570
              + L E+ G  EH        QL L++ + +  ++   K+ + + L+   QR  E  Q 
Sbjct: 1544 LQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQS 1603

Query: 571  IQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRY 630
            +   E    ++ N+   L       L +++ +     +++ +  +  R+   QL   + +
Sbjct: 1604 VLDAEI---RSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLH 1660

Query: 631  TYDKLGKLQRRNEELEEQCVQHGRVH-------ETMKQRLRQLDKHSQATAQQL------ 677
              D L    R NE+L+EQ     R +       E MK  L Q ++  + + Q+L      
Sbjct: 1661 LDDAL----RSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDR 1716

Query: 678  VQLLSKQNQLLLE-RQSLSEEVDRLRTQLPSMPQ 710
            VQLL  QN  L+  ++ L  ++ + + ++ +  Q
Sbjct: 1717 VQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQ 1750



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 112/537 (20%), Positives = 219/537 (40%), Gaps = 86/537 (16%)

Query: 45   EDAPNLSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRS 104
            E A   S S S      R A+ E+     V+QL+ L R+  + + E+S    +     ++
Sbjct: 1472 EAAQKESRSLSTELFKMRNAYEEV-----VDQLETLRRENKNLQEEISDLTEQIAETGKN 1526

Query: 105  LEHEETNMPTMH----DLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGL 160
            L+  E     +     DL   + +    + H E+++   + ELS +K+++   V+E +  
Sbjct: 1527 LQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEE 1586

Query: 161  QQQLKSQRQEETLREQTLLDASGNMHNSWITTGED-SGVGETSKRPFSHDNADFGKAASA 219
             +QLK   Q      Q++LDA     N  +   +   G     +    H N    +    
Sbjct: 1587 IEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAET--- 1643

Query: 220  GEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRV 279
                         ++     + QLK  +  L +  R+ EDLKEQL   E         R 
Sbjct: 1644 -------------QKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVE--------RRN 1682

Query: 280  GGLCLKCAQHEAVLSQTHTNVHMQTIERL-VKERDDLM----SALVSVRSSL-ADTQQRE 333
            G L  +  + +  L QT     +   E L   +R  L+    ++L++ +  L AD  Q +
Sbjct: 1683 GLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQ 1742

Query: 334  ASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQA--ERLEKELASQQEKRAIEKD 391
            A     +++     E+A    T A +  ++L+KE +  A  ER++K L     ++ ++  
Sbjct: 1743 AEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL-----EQTVKDL 1797

Query: 392  MMKKEITKEREYMGSKMLI--LSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMD 449
              + +  ++    G K  I  L   + +LE +++   K    A+    + + ++      
Sbjct: 1798 QHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVK----- 1852

Query: 450  VTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQ 509
                  EM YQ          AE++H+         L ++D  ++KL+ ++   K+  E+
Sbjct: 1853 ------EMTYQ----------AEEDHKNI-------LRLQDL-VDKLQAKVKSYKRQAEE 1888

Query: 510  EQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSK-EAKAQALQAQQREQ 565
             +++A      C R+       +H+L    +  D  +   +K  AK++ + +Q+ E+
Sbjct: 1889 AEEQANTQLSRCRRV-------QHELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 145/704 (20%), Positives = 308/704 (43%), Gaps = 81/704 (11%)

Query: 50   LSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEE 109
            L+   S     A  A  EL+     +  +D LR +  +++E+  +R+R+++        E
Sbjct: 1928 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSK--EQAELEAARQRQLAAEEERRRRE 1985

Query: 110  TNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQ 169
                    L        Q         K   EE+  +K K++      E  +Q+   Q Q
Sbjct: 1986 AEERVQKSLAAEEEAARQR--------KAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037

Query: 170  EETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASA------GEQL 223
                  Q  L A    H ++    ++  + +T ++  S  +   G+A +A       E+ 
Sbjct: 2038 LAQEAAQKRLQAEEKAH-AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096

Query: 224  ELEKLKLTYEEKCEIEESQ-LKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGL 282
             ++  +   + + ++EE++ LK    + A+ +   +   E+L+ +    AA         
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--- 2153

Query: 283  CLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQ 342
              + A  +   +      H +  E+ ++++  +   L ++R  L +T  ++    E++++
Sbjct: 2154 --QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2211

Query: 343  VLQISEEANFEKTKALIQCDQLRKEL---ERQAERLEKELAS-QQEKRAI---EKDMMKK 395
            +         E T+A  Q  Q+ +EL     Q E L K  A  + E RA+   +KD  ++
Sbjct: 2212 L-------KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 396  EITKEREYM------GSKMLILSQ-----------NIAQLEAQVEKVTKEKISAINQLEE 438
             + +E E M       +++ + +Q           ++AQ  A  EK+ KEK+ A+ +   
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324

Query: 439  I--QSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEH---REFRAKTNRDLEIKDQEI 493
            +  +++L  ++ ++ +     R Q +K  M +  AE+     R   A+  R LE+   E 
Sbjct: 2325 LKAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEA 2382

Query: 494  EKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS--- 550
            E+L++ + E  +   + ++ A   R++     E +GE  H+  L  QEK ++ Q+     
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQA----EEIGEKLHRTELATQEKVTLVQTLEIQR 2438

Query: 551  ------KEAKAQALQAQQREQELTQ---KIQQMEAQHDKTENEQYLLLTSQNTFLTKLKE 601
                   E   +A+   +RE+E  Q   K+ Q++++  +T  ++ LL  +Q    + L E
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498

Query: 602  ECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
            +   L +  E+  ++ ++++ QL Q++     +L + Q+R ++  EQ  +  R+  +M++
Sbjct: 2499 KDSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEE 2554

Query: 662  RLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
              R+  +  +   ++  +L   + Q   + + L+EE  RLR QL
Sbjct: 2555 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 148/716 (20%), Positives = 288/716 (40%), Gaps = 114/716 (15%)

Query: 74   VNQLKD----LLRQQADKESEVSPSRRRKM-SPLRSLEHEETNMPTMHDLVHTINDQ--- 125
            +N +KD    L+  +A  E   SP+++ K+ S   S+  E  ++ T +  + T+  Q   
Sbjct: 1276 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1335

Query: 126  --SQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASG 183
              S+ +  +E E +  +++ +  + ++  V    E  +Q  ++  Q +   E+   +   
Sbjct: 1336 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395

Query: 184  NMHNSWITTGEDSGVGETSKRPFSHD--------NADFGKAASAGEQLELEKLKLTYE-- 233
             M    +   E +   +  KR    +         A+    A   E  E  +L++  E  
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455

Query: 234  ------------------------EKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEF 269
                                     + E  E+Q +  + +    +R  +D  ++ +  E 
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515

Query: 270  LLAANT-------------CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLM 316
             LA+                  +  L L+  + E  L Q       Q    L   +    
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575

Query: 317  SALVSVRSSLAD-TQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERL 375
            + L S R+S A+ T Q E S  E+   V Q+ EEA   + +   + ++ R+E ER+ ER 
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE-RRAQQQAEAERAREEAERELERW 1634

Query: 376  E-------------KELASQQEKRAIEKDMMKKEITKEREYMG--SKMLILSQNIAQLEA 420
            +             +E+A Q+     E +  K+E  +E    G   +  +  + +A+ E 
Sbjct: 1635 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1694

Query: 421  Q-----VEKVTKEKISAINQLEEIQSQLASREMD---VTKVCGEMRYQLNKTNMEKDEAE 472
            +      E   +++++A  +L  ++++    E     + +    ++ +      ++ E E
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754

Query: 473  KEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESE 532
             E  + RA+    L  K +  E+ R   ++SKQ LE E  +     EE  RL  L  E++
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814

Query: 533  HQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQM-EAQHDKTENEQYLL-LT 590
             Q  L  ++               A Q  + E+ L +K+  + EA   KTE E  L    
Sbjct: 1815 RQRQLAEED--------------AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860

Query: 591  SQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNE-ELEEQC 649
            ++N  L +L E+     ++LE+          Q +Q K    ++L +L++ ++ ELE   
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEE----------QAAQHKADIEERLAQLRKASDSELER-- 1908

Query: 650  VQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSL-SEEVDRLRTQ 704
             Q G V +T++QR RQ+++   A      +  + + +L LE   + S   D LR++
Sbjct: 1909 -QKGLVEDTLRQR-RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1962



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 154/706 (21%), Positives = 294/706 (41%), Gaps = 88/706 (12%)

Query: 70   QSHAVNQLKDLLRQQADKESEVSPSRRRKMSP-----LRSLEHEETNMPTMHDLVHTIND 124
            Q+  V Q K L + +A+K+ E +    R+        +R  E  E  +     L      
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706

Query: 125  Q----SQYIHHLEAEVK-------FCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETL 173
            Q     Q +  L AE +         +EEL+ ++ +      + + L+ +L   R E   
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-- 1764

Query: 174  REQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQL-----ELEKL 228
              + LL +            E     E SK+    +   F + A    +L     E ++ 
Sbjct: 1765 --EVLLASKARAEE------ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816

Query: 229  KLTYEEKCEIEESQL-KFLRNDLA---EYQRTCEDLKEQLKHKEF------LLAANTCNR 278
            +   EE    + ++  + L   LA   E  R   + +  LK KE        LA +   +
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876

Query: 279  VGGLCLKCAQHEAVLSQTHTNVHMQT----------IERLVKERDDLMSALVSVRSSLAD 328
               L  + AQH+A + +    +   +          +E  +++R  +   ++++++S   
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1936

Query: 329  TQQREASAYEQVKQVLQISEEANFEKTKALIQCD---QLRKELERQA----ERLEKELAS 381
                +A    ++ ++   +E+    K +A ++     QL  E ER+     ER++K LA+
Sbjct: 1937 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996

Query: 382  QQE-----KRAIEK-DMMKKEITKER------EYMGSKMLILSQNIAQLEAQVEKVTKEK 429
            ++E     K A+E+ + +K ++ + R      E   ++ L L+Q  AQ   Q E+  K  
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE--KAH 2054

Query: 430  ISAINQLE-EIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEI 488
              A+ Q E E+Q  L   +  + ++ GE      +   E +EA  +     A++ R +E 
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQSRRQVE- 2112

Query: 489  KDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQS 548
               E E+L+   +E  Q   Q Q  A   R+E  +      ++E      +Q  D+  + 
Sbjct: 2113 ---EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2169

Query: 549  FSKEAKAQALQAQQREQELTQ-KIQQMEAQHDKT-ENEQYLLLTSQNTFL----TKLKEE 602
              K A+    Q  Q EQELT  ++Q  E  H K   +E+   L ++ T      ++++EE
Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229

Query: 603  CCTLAKKLEQISQ-KTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
              ++  ++E++S+ K R E    +   R   +    LQ   E++++   +  R+    ++
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289

Query: 662  --RLRQLDKHSQATAQQLVQ-LLSKQNQLLLERQSLSEEVDRLRTQ 704
              RLRQL +   A  + L + +L ++ Q + E   L  E + L+ Q
Sbjct: 2290 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 90/404 (22%), Positives = 188/404 (46%), Gaps = 31/404 (7%)

Query: 327  ADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELA-SQQEK 385
            A+ ++R A     +++  Q++E     K +A  +  +L++ ++ +  R E+    +QQ+K
Sbjct: 1356 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1415

Query: 386  RAIEKDMMKKEITKEREYMGS---------KMLILSQNIAQLEAQVEKVTKEKISAINQL 436
            R+I++++ +   + E E               L + + I  +  Q+E   +++  A  +L
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475

Query: 437  EEIQSQLASREMDVTKVCGE---MRYQLNKTNMEKDEAEKE---HREFRAKTNRDLEIKD 490
            + ++++    E    +   E   +R Q+   +  K +AE E     +  A+  R+ +   
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1535

Query: 491  QEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS 550
            Q +E+LR++ +E+++ L Q + + A   +  L   +   E+E Q       + + Q   S
Sbjct: 1536 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595

Query: 551  KEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKL 610
             + +  A+ AQ RE+   +  QQ EA+  + E E+ L              E   L  + 
Sbjct: 1596 LQEEHVAV-AQLREEAERRAQQQAEAERAREEAERELERWQLKA------NEALRLRLQA 1648

Query: 611  EQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHS 670
            E+++Q+    +AQ   EK+   ++  +  RR  + EEQ V+   + E   ++ RQL + +
Sbjct: 1649 EEVAQQ--KSLAQAEAEKQK--EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704

Query: 671  Q----ATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQ 710
                 A  Q+L++L ++  Q   +RQ L EE+ RL+ +  +  Q
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 133/652 (20%), Positives = 268/652 (41%), Gaps = 66/652 (10%)

Query: 68   LQQSH-AVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQS 126
            LQ+ H AV QL++   ++A +++E   +R       R LE  +        L     + +
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAE---RELERWQLKANEALRLRLQAEEVA 1652

Query: 127  QYIHHLEAEVKFCKEELSGMKNKI----QVVVLENEGLQQQLKSQRQEETLREQTLLDAS 182
            Q     +AE +  KEE      +     +  V + E  +Q+L+ QRQ      Q  L A 
Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712

Query: 183  GNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQ 242
              +    I    ++  GE  ++    + A   + A+A  Q   E      + + E+E   
Sbjct: 1713 QEL----IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768

Query: 243  LKFLRNDLAEYQRTCEDLKEQLKHK--EFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNV 300
                R +  E + T E  K++L+ +   F   A    R+  L  + A+ +  L++     
Sbjct: 1769 ASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAAR 1826

Query: 301  HMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQ 360
                 ER++ E+   +     +++      + + +  E++++   ++E+  F++ +   Q
Sbjct: 1827 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQRRRLEEQ 1883

Query: 361  CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEA 420
              Q + ++E +  +L K   S+ E+   +K +++  + + R+        + + I  L+A
Sbjct: 1884 AAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQ--------VEEEILALKA 1932

Query: 421  QVEKVTKEKISAINQLEEIQSQ----LASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHR 476
              EK    K     +L  I+S     L S+E    +   + +    +    ++  E+  +
Sbjct: 1933 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992

Query: 477  EFRAKTN--RDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQ 534
               A+    R  +   +E+E+L+ +++E+++  E+ +Q                 ES  Q
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ-----------------ESARQ 2035

Query: 535  LHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNT 594
            L L ++   + Q+    E KA A   QQ+EQEL Q +QQ ++  D+   E      +   
Sbjct: 2036 LQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA--- 2089

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQH-G 653
               +  EE    A++    S++   E  +L Q          + Q   E+L ++  Q   
Sbjct: 2090 --AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147

Query: 654  RVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
            R  +  +  LRQ     QA   ++ +      Q L ++  + +E+  LR QL
Sbjct: 2148 RRAQAEQAALRQ----KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 114/514 (22%), Positives = 224/514 (43%), Gaps = 73/514 (14%)

Query: 224  ELEKLKLTYEE---KCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVG 280
            ELE  K + ++   + E ++     LR++L   Q   E L+++   ++ +       RV 
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD-VEVERWRERVA 1182

Query: 281  GLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQV 340
             L     + +AVL+QT  +V  + +E+L ++      +   + + L D ++R+    EQ+
Sbjct: 1183 QLL---ERWQAVLAQT--DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ----EQI 1233

Query: 341  KQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIEKDMMKKEITK 399
            + +     +A  E+ +   Q   L +E+ER  E++E+ +  ++Q   AI KD   + +T 
Sbjct: 1234 QAMPLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINAI-KDYELQLVTY 1289

Query: 400  EREYMGSKMLILSQNIAQLEAQVEKVTKEKI-----SAINQLEEIQ---SQLASREMDVT 451
            +               AQLE       K K+     S I +  +++   S+L +      
Sbjct: 1290 K---------------AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1334

Query: 452  KVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIE-----KLRIELDESKQH 506
            K   E   ++ +     ++   E RE  A+    LE + Q  E     K + E  E+K+ 
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKEL 1393

Query: 507  LEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQ- 565
             ++ Q       EE +R  E   +++ Q    ++E   ++QS   E +A+A QA+  E+ 
Sbjct: 1394 QQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1446

Query: 566  --ELTQKIQQMEAQHDKTENE--------QYLLLTSQNTFLTK--LKEECCTLAKKLEQI 613
               + ++I+ +  Q + TE +        Q L   ++     K   +EE   L ++++  
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506

Query: 614  SQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQAT 673
            SQ+ R    +L+   +   +   + QR  + LEE  +Q     E  ++RLRQ +      
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQ 1562

Query: 674  AQQLVQLL--SKQNQLLLERQSLSEEVDRLRTQL 705
             Q  ++    S + +L  +R S +E+  +L   L
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 88/443 (19%), Positives = 193/443 (43%), Gaps = 52/443 (11%)

Query: 222  QLELEKLKLTYEEKCEI-----EESQLKFL-RNDLAEYQRTCEDLKEQLKHKEFLLAANT 275
            Q E EK+K   EE   +     E ++L+ L   DLA+ +   E +      KE + A   
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-----KEKMQAVQE 2321

Query: 276  CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSV-----RSSLADTQ 330
              R+        + EA L Q    +  +   RL ++++ +   L        R+  A+ Q
Sbjct: 2322 ATRL--------KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373

Query: 331  QREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIE 389
            ++   + E  +  L+++E +  +  +A     + RK+ E   E+L + ELA+Q++   ++
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQ-ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432

Query: 390  K-DMMKKEITKEREYMGSKMLILSQNIAQL--EAQVEKVTKEKISAINQLEEIQSQLASR 446
              ++ +++   + E +   +  L +   +L  EA++ ++  E++  + Q + +Q   A +
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492

Query: 447  EMDVTK----VCGEMRYQLNKTNMEK---DEAEKEHREFRAKTNRDLEIKDQEIEKLRIE 499
            +  +++    +  E   +  K  +E+   DE  K  ++ R +  R  +  +QE ++L   
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-QQLREEQQRQQQQMEQERQRLVAS 2551

Query: 500  LDESKQHLEQEQQKAALAREECLRL-------TELLGESEHQLHLTRQ---EKDSIQQSF 549
            ++E+++   + ++     +EE  +L        ELL E   +L    Q   E+     + 
Sbjct: 2552 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2611

Query: 550  SKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKK 609
            S+E  A  + A    + L      ++    + E E       +     +L+E     A++
Sbjct: 2612 SEEVTASQVAA---TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2668

Query: 610  LEQISQ--KTRSEIAQLSQEKRY 630
            L++++Q   T  E+A+    + Y
Sbjct: 2669 LQRLAQGHTTVDELARREDVRHY 2691



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 80/412 (19%), Positives = 171/412 (41%), Gaps = 43/412 (10%)

Query: 326  LADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEK 385
            +A+ Q+ +A      K V ++S EA  EK  AL +       L  + E    +L   +  
Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSAEA--EKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1080

Query: 386  RAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAIN-QLEEIQSQLA 444
             AI  + +K      R   G++ ++ +      EAQ    T  ++ A    L+++++Q  
Sbjct: 1081 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1140

Query: 445  SREMDVTKVCGEMR------YQLNKTNMEKDEAEKEHREFRAKTNR-------DLEIKDQ 491
            +++     +  E+R       +L + + E+D   +  RE  A+            +++ +
Sbjct: 1141 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR 1200

Query: 492  EIEKLRIELD---ESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEK---DSI 545
            E+E+L  +L    ES   L    Q A   +E+   +   L +S+      RQE+   + I
Sbjct: 1201 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEI 1258

Query: 546  QQSFSKEAKAQALQAQ------QREQELTQKIQQME-----AQHDKTENEQYLLLTSQNT 594
            ++   K  + Q    Q        E +L     Q+E     A+  K ++    ++     
Sbjct: 1259 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD 1318

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGR 654
              T   E     ++ ++ IS+  R    ++ +E+R    +  + + R  E+E    +  +
Sbjct: 1319 LRTHYSELTTLTSQYIKFISETLR----RMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1374

Query: 655  VHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQ----SLSEEVDRLR 702
            + E   Q   Q ++ ++   Q++ + + ++ +  ++ Q    S+ EE+ +LR
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1426


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 145/704 (20%), Positives = 308/704 (43%), Gaps = 81/704 (11%)

Query: 50   LSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEE 109
            L+   S     A  A  EL+     +  +D LR +  +++E+  +R+R+++        E
Sbjct: 1932 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSK--EQAELEAARQRQLAAEEERRRRE 1989

Query: 110  TNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQ 169
                    L        Q         K   EE+  +K K++      E  +Q+   Q Q
Sbjct: 1990 AEERVQKSLAAEEEAARQR--------KAALEEVERLKAKVEEARRLRERAEQESARQLQ 2041

Query: 170  EETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASA------GEQL 223
                  Q  L A    H ++    ++  + +T ++  S  +   G+A +A       E+ 
Sbjct: 2042 LAQEAAQKRLQAEEKAH-AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2100

Query: 224  ELEKLKLTYEEKCEIEESQ-LKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGL 282
             ++  +   + + ++EE++ LK    + A+ +   +   E+L+ +    AA         
Sbjct: 2101 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--- 2157

Query: 283  CLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQ 342
              + A  +   +      H +  E+ ++++  +   L ++R  L +T  ++    E++++
Sbjct: 2158 --QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2215

Query: 343  VLQISEEANFEKTKALIQCDQLRKEL---ERQAERLEKELAS-QQEKRAI---EKDMMKK 395
            +         E T+A  Q  Q+ +EL     Q E L K  A  + E RA+   +KD  ++
Sbjct: 2216 L-------KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268

Query: 396  EITKEREYM------GSKMLILSQ-----------NIAQLEAQVEKVTKEKISAINQLEE 438
             + +E E M       +++ + +Q           ++AQ  A  EK+ KEK+ A+ +   
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328

Query: 439  I--QSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEH---REFRAKTNRDLEIKDQEI 493
            +  +++L  ++ ++ +     R Q +K  M +  AE+     R   A+  R LE+   E 
Sbjct: 2329 LKAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEA 2386

Query: 494  EKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS--- 550
            E+L++ + E  +   + ++ A   R++     E +GE  H+  L  QEK ++ Q+     
Sbjct: 2387 ERLKLRVAEMSRAQARAEEDAQRFRKQA----EEIGEKLHRTELATQEKVTLVQTLEIQR 2442

Query: 551  ------KEAKAQALQAQQREQELTQ---KIQQMEAQHDKTENEQYLLLTSQNTFLTKLKE 601
                   E   +A+   +RE+E  Q   K+ Q++++  +T  ++ LL  +Q    + L E
Sbjct: 2443 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2502

Query: 602  ECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
            +   L +  E+  ++ ++++ QL Q++     +L + Q+R ++  EQ  +  R+  +M++
Sbjct: 2503 KDSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEE 2558

Query: 662  RLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
              R+  +  +   ++  +L   + Q   + + L+EE  RLR QL
Sbjct: 2559 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2602



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 148/716 (20%), Positives = 288/716 (40%), Gaps = 114/716 (15%)

Query: 74   VNQLKD----LLRQQADKESEVSPSRRRKM-SPLRSLEHEETNMPTMHDLVHTINDQ--- 125
            +N +KD    L+  +A  E   SP+++ K+ S   S+  E  ++ T +  + T+  Q   
Sbjct: 1280 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1339

Query: 126  --SQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASG 183
              S+ +  +E E +  +++ +  + ++  V    E  +Q  ++  Q +   E+   +   
Sbjct: 1340 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1399

Query: 184  NMHNSWITTGEDSGVGETSKRPFSHD--------NADFGKAASAGEQLELEKLKLTYE-- 233
             M    +   E +   +  KR    +         A+    A   E  E  +L++  E  
Sbjct: 1400 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459

Query: 234  ------------------------EKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEF 269
                                     + E  E+Q +  + +    +R  +D  ++ +  E 
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1519

Query: 270  LLAANT-------------CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLM 316
             LA+                  +  L L+  + E  L Q       Q    L   +    
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579

Query: 317  SALVSVRSSLAD-TQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERL 375
            + L S R+S A+ T Q E S  E+   V Q+ EEA   + +   + ++ R+E ER+ ER 
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE-RRAQQQAEAERAREEAERELERW 1638

Query: 376  E-------------KELASQQEKRAIEKDMMKKEITKEREYMG--SKMLILSQNIAQLEA 420
            +             +E+A Q+     E +  K+E  +E    G   +  +  + +A+ E 
Sbjct: 1639 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1698

Query: 421  Q-----VEKVTKEKISAINQLEEIQSQLASREMD---VTKVCGEMRYQLNKTNMEKDEAE 472
            +      E   +++++A  +L  ++++    E     + +    ++ +      ++ E E
Sbjct: 1699 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1758

Query: 473  KEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESE 532
             E  + RA+    L  K +  E+ R   ++SKQ LE E  +     EE  RL  L  E++
Sbjct: 1759 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818

Query: 533  HQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQM-EAQHDKTENEQYLL-LT 590
             Q  L  ++               A Q  + E+ L +K+  + EA   KTE E  L    
Sbjct: 1819 RQRQLAEED--------------AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1864

Query: 591  SQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNE-ELEEQC 649
            ++N  L +L E+     ++LE+          Q +Q K    ++L +L++ ++ ELE   
Sbjct: 1865 AENERLRRLAEDEAFQRRRLEE----------QAAQHKADIEERLAQLRKASDSELER-- 1912

Query: 650  VQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSL-SEEVDRLRTQ 704
             Q G V +T++QR RQ+++   A      +  + + +L LE   + S   D LR++
Sbjct: 1913 -QKGLVEDTLRQR-RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1966



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 154/706 (21%), Positives = 294/706 (41%), Gaps = 88/706 (12%)

Query: 70   QSHAVNQLKDLLRQQADKESEVSPSRRRKMSP-----LRSLEHEETNMPTMHDLVHTIND 124
            Q+  V Q K L + +A+K+ E +    R+        +R  E  E  +     L      
Sbjct: 1651 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1710

Query: 125  Q----SQYIHHLEAEVK-------FCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETL 173
            Q     Q +  L AE +         +EEL+ ++ +      + + L+ +L   R E   
Sbjct: 1711 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-- 1768

Query: 174  REQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQL-----ELEKL 228
              + LL +            E     E SK+    +   F + A    +L     E ++ 
Sbjct: 1769 --EVLLASKARAEE------ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1820

Query: 229  KLTYEEKCEIEESQL-KFLRNDLA---EYQRTCEDLKEQLKHKEF------LLAANTCNR 278
            +   EE    + ++  + L   LA   E  R   + +  LK KE        LA +   +
Sbjct: 1821 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1880

Query: 279  VGGLCLKCAQHEAVLSQTHTNVHMQT----------IERLVKERDDLMSALVSVRSSLAD 328
               L  + AQH+A + +    +   +          +E  +++R  +   ++++++S   
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1940

Query: 329  TQQREASAYEQVKQVLQISEEANFEKTKALIQCD---QLRKELERQA----ERLEKELAS 381
                +A    ++ ++   +E+    K +A ++     QL  E ER+     ER++K LA+
Sbjct: 1941 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2000

Query: 382  QQE-----KRAIEK-DMMKKEITKER------EYMGSKMLILSQNIAQLEAQVEKVTKEK 429
            ++E     K A+E+ + +K ++ + R      E   ++ L L+Q  AQ   Q E+  K  
Sbjct: 2001 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE--KAH 2058

Query: 430  ISAINQLE-EIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEI 488
              A+ Q E E+Q  L   +  + ++ GE      +   E +EA  +     A++ R +E 
Sbjct: 2059 AFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQSRRQVE- 2116

Query: 489  KDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQS 548
               E E+L+   +E  Q   Q Q  A   R+E  +      ++E      +Q  D+  + 
Sbjct: 2117 ---EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2173

Query: 549  FSKEAKAQALQAQQREQELTQ-KIQQMEAQHDKT-ENEQYLLLTSQNTFL----TKLKEE 602
              K A+    Q  Q EQELT  ++Q  E  H K   +E+   L ++ T      ++++EE
Sbjct: 2174 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2233

Query: 603  CCTLAKKLEQISQ-KTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
              ++  ++E++S+ K R E    +   R   +    LQ   E++++   +  R+    ++
Sbjct: 2234 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2293

Query: 662  --RLRQLDKHSQATAQQLVQ-LLSKQNQLLLERQSLSEEVDRLRTQ 704
              RLRQL +   A  + L + +L ++ Q + E   L  E + L+ Q
Sbjct: 2294 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2339



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 90/404 (22%), Positives = 188/404 (46%), Gaps = 31/404 (7%)

Query: 327  ADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELA-SQQEK 385
            A+ ++R A     +++  Q++E     K +A  +  +L++ ++ +  R E+    +QQ+K
Sbjct: 1360 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1419

Query: 386  RAIEKDMMKKEITKEREYMGS---------KMLILSQNIAQLEAQVEKVTKEKISAINQL 436
            R+I++++ +   + E E               L + + I  +  Q+E   +++  A  +L
Sbjct: 1420 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1479

Query: 437  EEIQSQLASREMDVTKVCGE---MRYQLNKTNMEKDEAEKE---HREFRAKTNRDLEIKD 490
            + ++++    E    +   E   +R Q+   +  K +AE E     +  A+  R+ +   
Sbjct: 1480 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1539

Query: 491  QEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS 550
            Q +E+LR++ +E+++ L Q + + A   +  L   +   E+E Q       + + Q   S
Sbjct: 1540 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1599

Query: 551  KEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKL 610
             + +  A+ AQ RE+   +  QQ EA+  + E E+ L              E   L  + 
Sbjct: 1600 LQEEHVAV-AQLREEAERRAQQQAEAERAREEAERELERWQLKA------NEALRLRLQA 1652

Query: 611  EQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHS 670
            E+++Q+    +AQ   EK+   ++  +  RR  + EEQ V+   + E   ++ RQL + +
Sbjct: 1653 EEVAQQ--KSLAQAEAEKQK--EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1708

Query: 671  Q----ATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQ 710
                 A  Q+L++L ++  Q   +RQ L EE+ RL+ +  +  Q
Sbjct: 1709 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1752



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 133/652 (20%), Positives = 268/652 (41%), Gaps = 66/652 (10%)

Query: 68   LQQSH-AVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQS 126
            LQ+ H AV QL++   ++A +++E   +R       R LE  +        L     + +
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEAERAREEAE---RELERWQLKANEALRLRLQAEEVA 1656

Query: 127  QYIHHLEAEVKFCKEELSGMKNKI----QVVVLENEGLQQQLKSQRQEETLREQTLLDAS 182
            Q     +AE +  KEE      +     +  V + E  +Q+L+ QRQ      Q  L A 
Sbjct: 1657 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1716

Query: 183  GNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQ 242
              +    I    ++  GE  ++    + A   + A+A  Q   E      + + E+E   
Sbjct: 1717 QEL----IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1772

Query: 243  LKFLRNDLAEYQRTCEDLKEQLKHK--EFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNV 300
                R +  E + T E  K++L+ +   F   A    R+  L  + A+ +  L++     
Sbjct: 1773 ASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAAR 1830

Query: 301  HMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQ 360
                 ER++ E+   +     +++      + + +  E++++   ++E+  F++ +   Q
Sbjct: 1831 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQRRRLEEQ 1887

Query: 361  CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEA 420
              Q + ++E +  +L K   S+ E+   +K +++  + + R+        + + I  L+A
Sbjct: 1888 AAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQ--------VEEEILALKA 1936

Query: 421  QVEKVTKEKISAINQLEEIQSQ----LASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHR 476
              EK    K     +L  I+S     L S+E    +   + +    +    ++  E+  +
Sbjct: 1937 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1996

Query: 477  EFRAKTN--RDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQ 534
               A+    R  +   +E+E+L+ +++E+++  E+ +Q                 ES  Q
Sbjct: 1997 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ-----------------ESARQ 2039

Query: 535  LHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNT 594
            L L ++   + Q+    E KA A   QQ+EQEL Q +QQ ++  D+   E      +   
Sbjct: 2040 LQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA--- 2093

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQH-G 653
               +  EE    A++    S++   E  +L Q          + Q   E+L ++  Q   
Sbjct: 2094 --AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2151

Query: 654  RVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
            R  +  +  LRQ     QA   ++ +      Q L ++  + +E+  LR QL
Sbjct: 2152 RRAQAEQAALRQ----KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2199



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 114/514 (22%), Positives = 224/514 (43%), Gaps = 73/514 (14%)

Query: 224  ELEKLKLTYEE---KCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVG 280
            ELE  K + ++   + E ++     LR++L   Q   E L+++   ++ +       RV 
Sbjct: 1128 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD-VEVERWRERVA 1186

Query: 281  GLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQV 340
             L     + +AVL+QT  +V  + +E+L ++      +   + + L D ++R+    EQ+
Sbjct: 1187 QLL---ERWQAVLAQT--DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ----EQI 1237

Query: 341  KQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIEKDMMKKEITK 399
            + +     +A  E+ +   Q   L +E+ER  E++E+ +  ++Q   AI KD   + +T 
Sbjct: 1238 QAMPLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINAI-KDYELQLVTY 1293

Query: 400  EREYMGSKMLILSQNIAQLEAQVEKVTKEKI-----SAINQLEEIQ---SQLASREMDVT 451
            +               AQLE       K K+     S I +  +++   S+L +      
Sbjct: 1294 K---------------AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1338

Query: 452  KVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIE-----KLRIELDESKQH 506
            K   E   ++ +     ++   E RE  A+    LE + Q  E     K + E  E+K+ 
Sbjct: 1339 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKEL 1397

Query: 507  LEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQ- 565
             ++ Q       EE +R  E   +++ Q    ++E   ++QS   E +A+A QA+  E+ 
Sbjct: 1398 QQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1450

Query: 566  --ELTQKIQQMEAQHDKTENE--------QYLLLTSQNTFLTK--LKEECCTLAKKLEQI 613
               + ++I+ +  Q + TE +        Q L   ++     K   +EE   L ++++  
Sbjct: 1451 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510

Query: 614  SQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQAT 673
            SQ+ R    +L+   +   +   + QR  + LEE  +Q     E  ++RLRQ +      
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQ 1566

Query: 674  AQQLVQLL--SKQNQLLLERQSLSEEVDRLRTQL 705
             Q  ++    S + +L  +R S +E+  +L   L
Sbjct: 1567 VQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 88/443 (19%), Positives = 193/443 (43%), Gaps = 52/443 (11%)

Query: 222  QLELEKLKLTYEEKCEI-----EESQLKFL-RNDLAEYQRTCEDLKEQLKHKEFLLAANT 275
            Q E EK+K   EE   +     E ++L+ L   DLA+ +   E +      KE + A   
Sbjct: 2271 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-----KEKMQAVQE 2325

Query: 276  CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSV-----RSSLADTQ 330
              R+        + EA L Q    +  +   RL ++++ +   L        R+  A+ Q
Sbjct: 2326 ATRL--------KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377

Query: 331  QREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIE 389
            ++   + E  +  L+++E +  +  +A     + RK+ E   E+L + ELA+Q++   ++
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQ-ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2436

Query: 390  K-DMMKKEITKEREYMGSKMLILSQNIAQL--EAQVEKVTKEKISAINQLEEIQSQLASR 446
              ++ +++   + E +   +  L +   +L  EA++ ++  E++  + Q + +Q   A +
Sbjct: 2437 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2496

Query: 447  EMDVTK----VCGEMRYQLNKTNMEK---DEAEKEHREFRAKTNRDLEIKDQEIEKLRIE 499
            +  +++    +  E   +  K  +E+   DE  K  ++ R +  R  +  +QE ++L   
Sbjct: 2497 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-QQLREEQQRQQQQMEQERQRLVAS 2555

Query: 500  LDESKQHLEQEQQKAALAREECLRL-------TELLGESEHQLHLTRQ---EKDSIQQSF 549
            ++E+++   + ++     +EE  +L        ELL E   +L    Q   E+     + 
Sbjct: 2556 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2615

Query: 550  SKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKK 609
            S+E  A  + A    + L      ++    + E E       +     +L+E     A++
Sbjct: 2616 SEEVTASQVAA---TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2672

Query: 610  LEQISQ--KTRSEIAQLSQEKRY 630
            L++++Q   T  E+A+    + Y
Sbjct: 2673 LQRLAQGHTTVDELARREDVRHY 2695



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 80/412 (19%), Positives = 171/412 (41%), Gaps = 43/412 (10%)

Query: 326  LADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEK 385
            +A+ Q+ +A      K V ++S EA  EK  AL +       L  + E    +L   +  
Sbjct: 1027 IAEQQKAQAEVEGLGKGVARLSAEA--EKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1084

Query: 386  RAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAIN-QLEEIQSQLA 444
             AI  + +K      R   G++ ++ +      EAQ    T  ++ A    L+++++Q  
Sbjct: 1085 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1144

Query: 445  SREMDVTKVCGEMR------YQLNKTNMEKDEAEKEHREFRAKTNR-------DLEIKDQ 491
            +++     +  E+R       +L + + E+D   +  RE  A+            +++ +
Sbjct: 1145 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR 1204

Query: 492  EIEKLRIELD---ESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEK---DSI 545
            E+E+L  +L    ES   L    Q A   +E+   +   L +S+      RQE+   + I
Sbjct: 1205 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEI 1262

Query: 546  QQSFSKEAKAQALQAQ------QREQELTQKIQQME-----AQHDKTENEQYLLLTSQNT 594
            ++   K  + Q    Q        E +L     Q+E     A+  K ++    ++     
Sbjct: 1263 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD 1322

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGR 654
              T   E     ++ ++ IS+  R    ++ +E+R    +  + + R  E+E    +  +
Sbjct: 1323 LRTHYSELTTLTSQYIKFISETLR----RMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1378

Query: 655  VHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQ----SLSEEVDRLR 702
            + E   Q   Q ++ ++   Q++ + + ++ +  ++ Q    S+ EE+ +LR
Sbjct: 1379 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1430


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 145/704 (20%), Positives = 308/704 (43%), Gaps = 81/704 (11%)

Query: 50   LSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEE 109
            L+   S     A  A  EL+     +  +D LR +  +++E+  +R+R+++        E
Sbjct: 1928 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSK--EQAELEAARQRQLAAEEERRRRE 1985

Query: 110  TNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQ 169
                    L        Q         K   EE+  +K K++      E  +Q+   Q Q
Sbjct: 1986 AEERVQKSLAAEEEAARQR--------KAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037

Query: 170  EETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASA------GEQL 223
                  Q  L A    H ++    ++  + +T ++  S  +   G+A +A       E+ 
Sbjct: 2038 LAQEAAQKRLQAEEKAH-AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096

Query: 224  ELEKLKLTYEEKCEIEESQ-LKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGL 282
             ++  +   + + ++EE++ LK    + A+ +   +   E+L+ +    AA         
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--- 2153

Query: 283  CLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQ 342
              + A  +   +      H +  E+ ++++  +   L ++R  L +T  ++    E++++
Sbjct: 2154 --QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2211

Query: 343  VLQISEEANFEKTKALIQCDQLRKEL---ERQAERLEKELAS-QQEKRAI---EKDMMKK 395
            +         E T+A  Q  Q+ +EL     Q E L K  A  + E RA+   +KD  ++
Sbjct: 2212 L-------KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 396  EITKEREYM------GSKMLILSQ-----------NIAQLEAQVEKVTKEKISAINQLEE 438
             + +E E M       +++ + +Q           ++AQ  A  EK+ KEK+ A+ +   
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324

Query: 439  I--QSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEH---REFRAKTNRDLEIKDQEI 493
            +  +++L  ++ ++ +     R Q +K  M +  AE+     R   A+  R LE+   E 
Sbjct: 2325 LKAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEA 2382

Query: 494  EKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS--- 550
            E+L++ + E  +   + ++ A   R++     E +GE  H+  L  QEK ++ Q+     
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQA----EEIGEKLHRTELATQEKVTLVQTLEIQR 2438

Query: 551  ------KEAKAQALQAQQREQELTQ---KIQQMEAQHDKTENEQYLLLTSQNTFLTKLKE 601
                   E   +A+   +RE+E  Q   K+ Q++++  +T  ++ LL  +Q    + L E
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498

Query: 602  ECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
            +   L +  E+  ++ ++++ QL Q++     +L + Q+R ++  EQ  +  R+  +M++
Sbjct: 2499 KDSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEE 2554

Query: 662  RLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
              R+  +  +   ++  +L   + Q   + + L+EE  RLR QL
Sbjct: 2555 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 148/716 (20%), Positives = 288/716 (40%), Gaps = 114/716 (15%)

Query: 74   VNQLKD----LLRQQADKESEVSPSRRRKM-SPLRSLEHEETNMPTMHDLVHTINDQ--- 125
            +N +KD    L+  +A  E   SP+++ K+ S   S+  E  ++ T +  + T+  Q   
Sbjct: 1276 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1335

Query: 126  --SQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASG 183
              S+ +  +E E +  +++ +  + ++  V    E  +Q  ++  Q +   E+   +   
Sbjct: 1336 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395

Query: 184  NMHNSWITTGEDSGVGETSKRPFSHD--------NADFGKAASAGEQLELEKLKLTYE-- 233
             M    +   E +   +  KR    +         A+    A   E  E  +L++  E  
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455

Query: 234  ------------------------EKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEF 269
                                     + E  E+Q +  + +    +R  +D  ++ +  E 
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515

Query: 270  LLAANT-------------CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLM 316
             LA+                  +  L L+  + E  L Q       Q    L   +    
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575

Query: 317  SALVSVRSSLAD-TQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERL 375
            + L S R+S A+ T Q E S  E+   V Q+ EEA   + +   + ++ R+E ER+ ER 
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE-RRAQQQAEAERAREEAERELERW 1634

Query: 376  E-------------KELASQQEKRAIEKDMMKKEITKEREYMG--SKMLILSQNIAQLEA 420
            +             +E+A Q+     E +  K+E  +E    G   +  +  + +A+ E 
Sbjct: 1635 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1694

Query: 421  Q-----VEKVTKEKISAINQLEEIQSQLASREMD---VTKVCGEMRYQLNKTNMEKDEAE 472
            +      E   +++++A  +L  ++++    E     + +    ++ +      ++ E E
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754

Query: 473  KEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESE 532
             E  + RA+    L  K +  E+ R   ++SKQ LE E  +     EE  RL  L  E++
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814

Query: 533  HQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQM-EAQHDKTENEQYLL-LT 590
             Q  L  ++               A Q  + E+ L +K+  + EA   KTE E  L    
Sbjct: 1815 RQRQLAEED--------------AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860

Query: 591  SQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNE-ELEEQC 649
            ++N  L +L E+     ++LE+          Q +Q K    ++L +L++ ++ ELE   
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEE----------QAAQHKADIEERLAQLRKASDSELER-- 1908

Query: 650  VQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSL-SEEVDRLRTQ 704
             Q G V +T++QR RQ+++   A      +  + + +L LE   + S   D LR++
Sbjct: 1909 -QKGLVEDTLRQR-RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1962



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 154/706 (21%), Positives = 294/706 (41%), Gaps = 88/706 (12%)

Query: 70   QSHAVNQLKDLLRQQADKESEVSPSRRRKMSP-----LRSLEHEETNMPTMHDLVHTIND 124
            Q+  V Q K L + +A+K+ E +    R+        +R  E  E  +     L      
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706

Query: 125  Q----SQYIHHLEAEVK-------FCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETL 173
            Q     Q +  L AE +         +EEL+ ++ +      + + L+ +L   R E   
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-- 1764

Query: 174  REQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQL-----ELEKL 228
              + LL +            E     E SK+    +   F + A    +L     E ++ 
Sbjct: 1765 --EVLLASKARAEE------ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816

Query: 229  KLTYEEKCEIEESQL-KFLRNDLA---EYQRTCEDLKEQLKHKEF------LLAANTCNR 278
            +   EE    + ++  + L   LA   E  R   + +  LK KE        LA +   +
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876

Query: 279  VGGLCLKCAQHEAVLSQTHTNVHMQT----------IERLVKERDDLMSALVSVRSSLAD 328
               L  + AQH+A + +    +   +          +E  +++R  +   ++++++S   
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1936

Query: 329  TQQREASAYEQVKQVLQISEEANFEKTKALIQCD---QLRKELERQA----ERLEKELAS 381
                +A    ++ ++   +E+    K +A ++     QL  E ER+     ER++K LA+
Sbjct: 1937 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996

Query: 382  QQE-----KRAIEK-DMMKKEITKER------EYMGSKMLILSQNIAQLEAQVEKVTKEK 429
            ++E     K A+E+ + +K ++ + R      E   ++ L L+Q  AQ   Q E+  K  
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE--KAH 2054

Query: 430  ISAINQLE-EIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEI 488
              A+ Q E E+Q  L   +  + ++ GE      +   E +EA  +     A++ R +E 
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQSRRQVE- 2112

Query: 489  KDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQS 548
               E E+L+   +E  Q   Q Q  A   R+E  +      ++E      +Q  D+  + 
Sbjct: 2113 ---EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2169

Query: 549  FSKEAKAQALQAQQREQELTQ-KIQQMEAQHDKT-ENEQYLLLTSQNTFL----TKLKEE 602
              K A+    Q  Q EQELT  ++Q  E  H K   +E+   L ++ T      ++++EE
Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229

Query: 603  CCTLAKKLEQISQ-KTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
              ++  ++E++S+ K R E    +   R   +    LQ   E++++   +  R+    ++
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289

Query: 662  --RLRQLDKHSQATAQQLVQ-LLSKQNQLLLERQSLSEEVDRLRTQ 704
              RLRQL +   A  + L + +L ++ Q + E   L  E + L+ Q
Sbjct: 2290 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 90/404 (22%), Positives = 188/404 (46%), Gaps = 31/404 (7%)

Query: 327  ADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELA-SQQEK 385
            A+ ++R A     +++  Q++E     K +A  +  +L++ ++ +  R E+    +QQ+K
Sbjct: 1356 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1415

Query: 386  RAIEKDMMKKEITKEREYMGS---------KMLILSQNIAQLEAQVEKVTKEKISAINQL 436
            R+I++++ +   + E E               L + + I  +  Q+E   +++  A  +L
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475

Query: 437  EEIQSQLASREMDVTKVCGE---MRYQLNKTNMEKDEAEKE---HREFRAKTNRDLEIKD 490
            + ++++    E    +   E   +R Q+   +  K +AE E     +  A+  R+ +   
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1535

Query: 491  QEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS 550
            Q +E+LR++ +E+++ L Q + + A   +  L   +   E+E Q       + + Q   S
Sbjct: 1536 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595

Query: 551  KEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKL 610
             + +  A+ AQ RE+   +  QQ EA+  + E E+ L              E   L  + 
Sbjct: 1596 LQEEHVAV-AQLREEAERRAQQQAEAERAREEAERELERWQLKA------NEALRLRLQA 1648

Query: 611  EQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHS 670
            E+++Q+    +AQ   EK+   ++  +  RR  + EEQ V+   + E   ++ RQL + +
Sbjct: 1649 EEVAQQ--KSLAQAEAEKQK--EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704

Query: 671  Q----ATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQ 710
                 A  Q+L++L ++  Q   +RQ L EE+ RL+ +  +  Q
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 133/652 (20%), Positives = 268/652 (41%), Gaps = 66/652 (10%)

Query: 68   LQQSH-AVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQS 126
            LQ+ H AV QL++   ++A +++E   +R       R LE  +        L     + +
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAE---RELERWQLKANEALRLRLQAEEVA 1652

Query: 127  QYIHHLEAEVKFCKEELSGMKNKI----QVVVLENEGLQQQLKSQRQEETLREQTLLDAS 182
            Q     +AE +  KEE      +     +  V + E  +Q+L+ QRQ      Q  L A 
Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712

Query: 183  GNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQ 242
              +    I    ++  GE  ++    + A   + A+A  Q   E      + + E+E   
Sbjct: 1713 QEL----IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768

Query: 243  LKFLRNDLAEYQRTCEDLKEQLKHK--EFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNV 300
                R +  E + T E  K++L+ +   F   A    R+  L  + A+ +  L++     
Sbjct: 1769 ASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAAR 1826

Query: 301  HMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQ 360
                 ER++ E+   +     +++      + + +  E++++   ++E+  F++ +   Q
Sbjct: 1827 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQRRRLEEQ 1883

Query: 361  CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEA 420
              Q + ++E +  +L K   S+ E+   +K +++  + + R+        + + I  L+A
Sbjct: 1884 AAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQ--------VEEEILALKA 1932

Query: 421  QVEKVTKEKISAINQLEEIQSQ----LASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHR 476
              EK    K     +L  I+S     L S+E    +   + +    +    ++  E+  +
Sbjct: 1933 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992

Query: 477  EFRAKTN--RDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQ 534
               A+    R  +   +E+E+L+ +++E+++  E+ +Q                 ES  Q
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ-----------------ESARQ 2035

Query: 535  LHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNT 594
            L L ++   + Q+    E KA A   QQ+EQEL Q +QQ ++  D+   E      +   
Sbjct: 2036 LQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA--- 2089

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQH-G 653
               +  EE    A++    S++   E  +L Q          + Q   E+L ++  Q   
Sbjct: 2090 --AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147

Query: 654  RVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
            R  +  +  LRQ     QA   ++ +      Q L ++  + +E+  LR QL
Sbjct: 2148 RRAQAEQAALRQ----KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 114/514 (22%), Positives = 224/514 (43%), Gaps = 73/514 (14%)

Query: 224  ELEKLKLTYEE---KCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVG 280
            ELE  K + ++   + E ++     LR++L   Q   E L+++   ++ +       RV 
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD-VEVERWRERVA 1182

Query: 281  GLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQV 340
             L     + +AVL+QT  +V  + +E+L ++      +   + + L D ++R+    EQ+
Sbjct: 1183 QLL---ERWQAVLAQT--DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ----EQI 1233

Query: 341  KQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIEKDMMKKEITK 399
            + +     +A  E+ +   Q   L +E+ER  E++E+ +  ++Q   AI KD   + +T 
Sbjct: 1234 QAMPLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINAI-KDYELQLVTY 1289

Query: 400  EREYMGSKMLILSQNIAQLEAQVEKVTKEKI-----SAINQLEEIQ---SQLASREMDVT 451
            +               AQLE       K K+     S I +  +++   S+L +      
Sbjct: 1290 K---------------AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1334

Query: 452  KVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIE-----KLRIELDESKQH 506
            K   E   ++ +     ++   E RE  A+    LE + Q  E     K + E  E+K+ 
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKEL 1393

Query: 507  LEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQ- 565
             ++ Q       EE +R  E   +++ Q    ++E   ++QS   E +A+A QA+  E+ 
Sbjct: 1394 QQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1446

Query: 566  --ELTQKIQQMEAQHDKTENE--------QYLLLTSQNTFLTK--LKEECCTLAKKLEQI 613
               + ++I+ +  Q + TE +        Q L   ++     K   +EE   L ++++  
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506

Query: 614  SQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQAT 673
            SQ+ R    +L+   +   +   + QR  + LEE  +Q     E  ++RLRQ +      
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQ 1562

Query: 674  AQQLVQLL--SKQNQLLLERQSLSEEVDRLRTQL 705
             Q  ++    S + +L  +R S +E+  +L   L
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 88/443 (19%), Positives = 193/443 (43%), Gaps = 52/443 (11%)

Query: 222  QLELEKLKLTYEEKCEI-----EESQLKFL-RNDLAEYQRTCEDLKEQLKHKEFLLAANT 275
            Q E EK+K   EE   +     E ++L+ L   DLA+ +   E +      KE + A   
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-----KEKMQAVQE 2321

Query: 276  CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSV-----RSSLADTQ 330
              R+        + EA L Q    +  +   RL ++++ +   L        R+  A+ Q
Sbjct: 2322 ATRL--------KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373

Query: 331  QREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIE 389
            ++   + E  +  L+++E +  +  +A     + RK+ E   E+L + ELA+Q++   ++
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQ-ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432

Query: 390  K-DMMKKEITKEREYMGSKMLILSQNIAQL--EAQVEKVTKEKISAINQLEEIQSQLASR 446
              ++ +++   + E +   +  L +   +L  EA++ ++  E++  + Q + +Q   A +
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492

Query: 447  EMDVTK----VCGEMRYQLNKTNMEK---DEAEKEHREFRAKTNRDLEIKDQEIEKLRIE 499
            +  +++    +  E   +  K  +E+   DE  K  ++ R +  R  +  +QE ++L   
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-QQLREEQQRQQQQMEQERQRLVAS 2551

Query: 500  LDESKQHLEQEQQKAALAREECLRL-------TELLGESEHQLHLTRQ---EKDSIQQSF 549
            ++E+++   + ++     +EE  +L        ELL E   +L    Q   E+     + 
Sbjct: 2552 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2611

Query: 550  SKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKK 609
            S+E  A  + A    + L      ++    + E E       +     +L+E     A++
Sbjct: 2612 SEEVTASQVAA---TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2668

Query: 610  LEQISQ--KTRSEIAQLSQEKRY 630
            L++++Q   T  E+A+    + Y
Sbjct: 2669 LQRLAQGHTTVDELARREDVRHY 2691



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 80/412 (19%), Positives = 171/412 (41%), Gaps = 43/412 (10%)

Query: 326  LADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEK 385
            +A+ Q+ +A      K V ++S EA  EK  AL +       L  + E    +L   +  
Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSAEA--EKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1080

Query: 386  RAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAIN-QLEEIQSQLA 444
             AI  + +K      R   G++ ++ +      EAQ    T  ++ A    L+++++Q  
Sbjct: 1081 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1140

Query: 445  SREMDVTKVCGEMR------YQLNKTNMEKDEAEKEHREFRAKTNR-------DLEIKDQ 491
            +++     +  E+R       +L + + E+D   +  RE  A+            +++ +
Sbjct: 1141 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR 1200

Query: 492  EIEKLRIELD---ESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEK---DSI 545
            E+E+L  +L    ES   L    Q A   +E+   +   L +S+      RQE+   + I
Sbjct: 1201 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEI 1258

Query: 546  QQSFSKEAKAQALQAQ------QREQELTQKIQQME-----AQHDKTENEQYLLLTSQNT 594
            ++   K  + Q    Q        E +L     Q+E     A+  K ++    ++     
Sbjct: 1259 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD 1318

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGR 654
              T   E     ++ ++ IS+  R    ++ +E+R    +  + + R  E+E    +  +
Sbjct: 1319 LRTHYSELTTLTSQYIKFISETLR----RMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1374

Query: 655  VHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQ----SLSEEVDRLR 702
            + E   Q   Q ++ ++   Q++ + + ++ +  ++ Q    S+ EE+ +LR
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1426


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 145/704 (20%), Positives = 308/704 (43%), Gaps = 81/704 (11%)

Query: 50   LSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEE 109
            L+   S     A  A  EL+     +  +D LR +  +++E+  +R+R+++        E
Sbjct: 1896 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSK--EQAELEAARQRQLAAEEERRRRE 1953

Query: 110  TNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQ 169
                    L        Q         K   EE+  +K K++      E  +Q+   Q Q
Sbjct: 1954 AEERVQKSLAAEEEAARQR--------KAALEEVERLKAKVEEARRLRERAEQESARQLQ 2005

Query: 170  EETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASA------GEQL 223
                  Q  L A    H ++    ++  + +T ++  S  +   G+A +A       E+ 
Sbjct: 2006 LAQEAAQKRLQAEEKAH-AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2064

Query: 224  ELEKLKLTYEEKCEIEESQ-LKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGL 282
             ++  +   + + ++EE++ LK    + A+ +   +   E+L+ +    AA         
Sbjct: 2065 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--- 2121

Query: 283  CLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQ 342
              + A  +   +      H +  E+ ++++  +   L ++R  L +T  ++    E++++
Sbjct: 2122 --QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2179

Query: 343  VLQISEEANFEKTKALIQCDQLRKEL---ERQAERLEKELAS-QQEKRAI---EKDMMKK 395
            +         E T+A  Q  Q+ +EL     Q E L K  A  + E RA+   +KD  ++
Sbjct: 2180 L-------KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232

Query: 396  EITKEREYM------GSKMLILSQ-----------NIAQLEAQVEKVTKEKISAINQLEE 438
             + +E E M       +++ + +Q           ++AQ  A  EK+ KEK+ A+ +   
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292

Query: 439  I--QSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEH---REFRAKTNRDLEIKDQEI 493
            +  +++L  ++ ++ +     R Q +K  M +  AE+     R   A+  R LE+   E 
Sbjct: 2293 LKAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEA 2350

Query: 494  EKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS--- 550
            E+L++ + E  +   + ++ A   R++     E +GE  H+  L  QEK ++ Q+     
Sbjct: 2351 ERLKLRVAEMSRAQARAEEDAQRFRKQA----EEIGEKLHRTELATQEKVTLVQTLEIQR 2406

Query: 551  ------KEAKAQALQAQQREQELTQ---KIQQMEAQHDKTENEQYLLLTSQNTFLTKLKE 601
                   E   +A+   +RE+E  Q   K+ Q++++  +T  ++ LL  +Q    + L E
Sbjct: 2407 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2466

Query: 602  ECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
            +   L +  E+  ++ ++++ QL Q++     +L + Q+R ++  EQ  +  R+  +M++
Sbjct: 2467 KDSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEE 2522

Query: 662  RLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
              R+  +  +   ++  +L   + Q   + + L+EE  RLR QL
Sbjct: 2523 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2566



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 148/716 (20%), Positives = 288/716 (40%), Gaps = 114/716 (15%)

Query: 74   VNQLKD----LLRQQADKESEVSPSRRRKM-SPLRSLEHEETNMPTMHDLVHTINDQ--- 125
            +N +KD    L+  +A  E   SP+++ K+ S   S+  E  ++ T +  + T+  Q   
Sbjct: 1244 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1303

Query: 126  --SQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASG 183
              S+ +  +E E +  +++ +  + ++  V    E  +Q  ++  Q +   E+   +   
Sbjct: 1304 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1363

Query: 184  NMHNSWITTGEDSGVGETSKRPFSHD--------NADFGKAASAGEQLELEKLKLTYE-- 233
             M    +   E +   +  KR    +         A+    A   E  E  +L++  E  
Sbjct: 1364 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423

Query: 234  ------------------------EKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEF 269
                                     + E  E+Q +  + +    +R  +D  ++ +  E 
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1483

Query: 270  LLAANT-------------CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLM 316
             LA+                  +  L L+  + E  L Q       Q    L   +    
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543

Query: 317  SALVSVRSSLAD-TQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERL 375
            + L S R+S A+ T Q E S  E+   V Q+ EEA   + +   + ++ R+E ER+ ER 
Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE-RRAQQQAEAERAREEAERELERW 1602

Query: 376  E-------------KELASQQEKRAIEKDMMKKEITKEREYMG--SKMLILSQNIAQLEA 420
            +             +E+A Q+     E +  K+E  +E    G   +  +  + +A+ E 
Sbjct: 1603 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1662

Query: 421  Q-----VEKVTKEKISAINQLEEIQSQLASREMD---VTKVCGEMRYQLNKTNMEKDEAE 472
            +      E   +++++A  +L  ++++    E     + +    ++ +      ++ E E
Sbjct: 1663 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1722

Query: 473  KEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESE 532
             E  + RA+    L  K +  E+ R   ++SKQ LE E  +     EE  RL  L  E++
Sbjct: 1723 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782

Query: 533  HQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQM-EAQHDKTENEQYLL-LT 590
             Q  L  ++               A Q  + E+ L +K+  + EA   KTE E  L    
Sbjct: 1783 RQRQLAEED--------------AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1828

Query: 591  SQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNE-ELEEQC 649
            ++N  L +L E+     ++LE+          Q +Q K    ++L +L++ ++ ELE   
Sbjct: 1829 AENERLRRLAEDEAFQRRRLEE----------QAAQHKADIEERLAQLRKASDSELER-- 1876

Query: 650  VQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSL-SEEVDRLRTQ 704
             Q G V +T++QR RQ+++   A      +  + + +L LE   + S   D LR++
Sbjct: 1877 -QKGLVEDTLRQR-RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1930



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 154/706 (21%), Positives = 294/706 (41%), Gaps = 88/706 (12%)

Query: 70   QSHAVNQLKDLLRQQADKESEVSPSRRRKMSP-----LRSLEHEETNMPTMHDLVHTIND 124
            Q+  V Q K L + +A+K+ E +    R+        +R  E  E  +     L      
Sbjct: 1615 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1674

Query: 125  Q----SQYIHHLEAEVK-------FCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETL 173
            Q     Q +  L AE +         +EEL+ ++ +      + + L+ +L   R E   
Sbjct: 1675 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-- 1732

Query: 174  REQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQL-----ELEKL 228
              + LL +            E     E SK+    +   F + A    +L     E ++ 
Sbjct: 1733 --EVLLASKARAEE------ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1784

Query: 229  KLTYEEKCEIEESQL-KFLRNDLA---EYQRTCEDLKEQLKHKEF------LLAANTCNR 278
            +   EE    + ++  + L   LA   E  R   + +  LK KE        LA +   +
Sbjct: 1785 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1844

Query: 279  VGGLCLKCAQHEAVLSQTHTNVHMQT----------IERLVKERDDLMSALVSVRSSLAD 328
               L  + AQH+A + +    +   +          +E  +++R  +   ++++++S   
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1904

Query: 329  TQQREASAYEQVKQVLQISEEANFEKTKALIQCD---QLRKELERQA----ERLEKELAS 381
                +A    ++ ++   +E+    K +A ++     QL  E ER+     ER++K LA+
Sbjct: 1905 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1964

Query: 382  QQE-----KRAIEK-DMMKKEITKER------EYMGSKMLILSQNIAQLEAQVEKVTKEK 429
            ++E     K A+E+ + +K ++ + R      E   ++ L L+Q  AQ   Q E+  K  
Sbjct: 1965 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE--KAH 2022

Query: 430  ISAINQLE-EIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEI 488
              A+ Q E E+Q  L   +  + ++ GE      +   E +EA  +     A++ R +E 
Sbjct: 2023 AFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQSRRQVE- 2080

Query: 489  KDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQS 548
               E E+L+   +E  Q   Q Q  A   R+E  +      ++E      +Q  D+  + 
Sbjct: 2081 ---EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2137

Query: 549  FSKEAKAQALQAQQREQELTQ-KIQQMEAQHDKT-ENEQYLLLTSQNTFL----TKLKEE 602
              K A+    Q  Q EQELT  ++Q  E  H K   +E+   L ++ T      ++++EE
Sbjct: 2138 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2197

Query: 603  CCTLAKKLEQISQ-KTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
              ++  ++E++S+ K R E    +   R   +    LQ   E++++   +  R+    ++
Sbjct: 2198 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2257

Query: 662  --RLRQLDKHSQATAQQLVQ-LLSKQNQLLLERQSLSEEVDRLRTQ 704
              RLRQL +   A  + L + +L ++ Q + E   L  E + L+ Q
Sbjct: 2258 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2303



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 90/404 (22%), Positives = 188/404 (46%), Gaps = 31/404 (7%)

Query: 327  ADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELA-SQQEK 385
            A+ ++R A     +++  Q++E     K +A  +  +L++ ++ +  R E+    +QQ+K
Sbjct: 1324 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1383

Query: 386  RAIEKDMMKKEITKEREYMGS---------KMLILSQNIAQLEAQVEKVTKEKISAINQL 436
            R+I++++ +   + E E               L + + I  +  Q+E   +++  A  +L
Sbjct: 1384 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1443

Query: 437  EEIQSQLASREMDVTKVCGE---MRYQLNKTNMEKDEAEKE---HREFRAKTNRDLEIKD 490
            + ++++    E    +   E   +R Q+   +  K +AE E     +  A+  R+ +   
Sbjct: 1444 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1503

Query: 491  QEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS 550
            Q +E+LR++ +E+++ L Q + + A   +  L   +   E+E Q       + + Q   S
Sbjct: 1504 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1563

Query: 551  KEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKL 610
             + +  A+ AQ RE+   +  QQ EA+  + E E+ L              E   L  + 
Sbjct: 1564 LQEEHVAV-AQLREEAERRAQQQAEAERAREEAERELERWQLKA------NEALRLRLQA 1616

Query: 611  EQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHS 670
            E+++Q+    +AQ   EK+   ++  +  RR  + EEQ V+   + E   ++ RQL + +
Sbjct: 1617 EEVAQQ--KSLAQAEAEKQK--EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1672

Query: 671  Q----ATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQ 710
                 A  Q+L++L ++  Q   +RQ L EE+ RL+ +  +  Q
Sbjct: 1673 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1716



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 133/652 (20%), Positives = 268/652 (41%), Gaps = 66/652 (10%)

Query: 68   LQQSH-AVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQS 126
            LQ+ H AV QL++   ++A +++E   +R       R LE  +        L     + +
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEAERAREEAE---RELERWQLKANEALRLRLQAEEVA 1620

Query: 127  QYIHHLEAEVKFCKEELSGMKNKI----QVVVLENEGLQQQLKSQRQEETLREQTLLDAS 182
            Q     +AE +  KEE      +     +  V + E  +Q+L+ QRQ      Q  L A 
Sbjct: 1621 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1680

Query: 183  GNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQ 242
              +    I    ++  GE  ++    + A   + A+A  Q   E      + + E+E   
Sbjct: 1681 QEL----IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1736

Query: 243  LKFLRNDLAEYQRTCEDLKEQLKHK--EFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNV 300
                R +  E + T E  K++L+ +   F   A    R+  L  + A+ +  L++     
Sbjct: 1737 ASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAAR 1794

Query: 301  HMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQ 360
                 ER++ E+   +     +++      + + +  E++++   ++E+  F++ +   Q
Sbjct: 1795 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQRRRLEEQ 1851

Query: 361  CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEA 420
              Q + ++E +  +L K   S+ E+   +K +++  + + R+        + + I  L+A
Sbjct: 1852 AAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQ--------VEEEILALKA 1900

Query: 421  QVEKVTKEKISAINQLEEIQSQ----LASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHR 476
              EK    K     +L  I+S     L S+E    +   + +    +    ++  E+  +
Sbjct: 1901 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1960

Query: 477  EFRAKTN--RDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQ 534
               A+    R  +   +E+E+L+ +++E+++  E+ +Q                 ES  Q
Sbjct: 1961 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ-----------------ESARQ 2003

Query: 535  LHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNT 594
            L L ++   + Q+    E KA A   QQ+EQEL Q +QQ ++  D+   E      +   
Sbjct: 2004 LQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA--- 2057

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQH-G 653
               +  EE    A++    S++   E  +L Q          + Q   E+L ++  Q   
Sbjct: 2058 --AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2115

Query: 654  RVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
            R  +  +  LRQ     QA   ++ +      Q L ++  + +E+  LR QL
Sbjct: 2116 RRAQAEQAALRQ----KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2163



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 114/514 (22%), Positives = 224/514 (43%), Gaps = 73/514 (14%)

Query: 224  ELEKLKLTYEE---KCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVG 280
            ELE  K + ++   + E ++     LR++L   Q   E L+++   ++ +       RV 
Sbjct: 1092 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD-VEVERWRERVA 1150

Query: 281  GLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQV 340
             L     + +AVL+QT  +V  + +E+L ++      +   + + L D ++R+    EQ+
Sbjct: 1151 QLL---ERWQAVLAQT--DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ----EQI 1201

Query: 341  KQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIEKDMMKKEITK 399
            + +     +A  E+ +   Q   L +E+ER  E++E+ +  ++Q   AI KD   + +T 
Sbjct: 1202 QAMPLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINAI-KDYELQLVTY 1257

Query: 400  EREYMGSKMLILSQNIAQLEAQVEKVTKEKI-----SAINQLEEIQ---SQLASREMDVT 451
            +               AQLE       K K+     S I +  +++   S+L +      
Sbjct: 1258 K---------------AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1302

Query: 452  KVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIE-----KLRIELDESKQH 506
            K   E   ++ +     ++   E RE  A+    LE + Q  E     K + E  E+K+ 
Sbjct: 1303 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKEL 1361

Query: 507  LEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQ- 565
             ++ Q       EE +R  E   +++ Q    ++E   ++QS   E +A+A QA+  E+ 
Sbjct: 1362 QQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1414

Query: 566  --ELTQKIQQMEAQHDKTENE--------QYLLLTSQNTFLTK--LKEECCTLAKKLEQI 613
               + ++I+ +  Q + TE +        Q L   ++     K   +EE   L ++++  
Sbjct: 1415 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474

Query: 614  SQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQAT 673
            SQ+ R    +L+   +   +   + QR  + LEE  +Q     E  ++RLRQ +      
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQ 1530

Query: 674  AQQLVQLL--SKQNQLLLERQSLSEEVDRLRTQL 705
             Q  ++    S + +L  +R S +E+  +L   L
Sbjct: 1531 VQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 88/443 (19%), Positives = 193/443 (43%), Gaps = 52/443 (11%)

Query: 222  QLELEKLKLTYEEKCEI-----EESQLKFL-RNDLAEYQRTCEDLKEQLKHKEFLLAANT 275
            Q E EK+K   EE   +     E ++L+ L   DLA+ +   E +      KE + A   
Sbjct: 2235 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-----KEKMQAVQE 2289

Query: 276  CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSV-----RSSLADTQ 330
              R+        + EA L Q    +  +   RL ++++ +   L        R+  A+ Q
Sbjct: 2290 ATRL--------KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341

Query: 331  QREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIE 389
            ++   + E  +  L+++E +  +  +A     + RK+ E   E+L + ELA+Q++   ++
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQ-ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2400

Query: 390  K-DMMKKEITKEREYMGSKMLILSQNIAQL--EAQVEKVTKEKISAINQLEEIQSQLASR 446
              ++ +++   + E +   +  L +   +L  EA++ ++  E++  + Q + +Q   A +
Sbjct: 2401 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2460

Query: 447  EMDVTK----VCGEMRYQLNKTNMEK---DEAEKEHREFRAKTNRDLEIKDQEIEKLRIE 499
            +  +++    +  E   +  K  +E+   DE  K  ++ R +  R  +  +QE ++L   
Sbjct: 2461 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-QQLREEQQRQQQQMEQERQRLVAS 2519

Query: 500  LDESKQHLEQEQQKAALAREECLRL-------TELLGESEHQLHLTRQ---EKDSIQQSF 549
            ++E+++   + ++     +EE  +L        ELL E   +L    Q   E+     + 
Sbjct: 2520 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2579

Query: 550  SKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKK 609
            S+E  A  + A    + L      ++    + E E       +     +L+E     A++
Sbjct: 2580 SEEVTASQVAA---TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2636

Query: 610  LEQISQ--KTRSEIAQLSQEKRY 630
            L++++Q   T  E+A+    + Y
Sbjct: 2637 LQRLAQGHTTVDELARREDVRHY 2659



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 80/412 (19%), Positives = 171/412 (41%), Gaps = 43/412 (10%)

Query: 326  LADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEK 385
            +A+ Q+ +A      K V ++S EA  EK  AL +       L  + E    +L   +  
Sbjct: 991  IAEQQKAQAEVEGLGKGVARLSAEA--EKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1048

Query: 386  RAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAIN-QLEEIQSQLA 444
             AI  + +K      R   G++ ++ +      EAQ    T  ++ A    L+++++Q  
Sbjct: 1049 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1108

Query: 445  SREMDVTKVCGEMR------YQLNKTNMEKDEAEKEHREFRAKTNR-------DLEIKDQ 491
            +++     +  E+R       +L + + E+D   +  RE  A+            +++ +
Sbjct: 1109 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR 1168

Query: 492  EIEKLRIELD---ESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEK---DSI 545
            E+E+L  +L    ES   L    Q A   +E+   +   L +S+      RQE+   + I
Sbjct: 1169 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEI 1226

Query: 546  QQSFSKEAKAQALQAQ------QREQELTQKIQQME-----AQHDKTENEQYLLLTSQNT 594
            ++   K  + Q    Q        E +L     Q+E     A+  K ++    ++     
Sbjct: 1227 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD 1286

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGR 654
              T   E     ++ ++ IS+  R    ++ +E+R    +  + + R  E+E    +  +
Sbjct: 1287 LRTHYSELTTLTSQYIKFISETLR----RMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1342

Query: 655  VHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQ----SLSEEVDRLR 702
            + E   Q   Q ++ ++   Q++ + + ++ +  ++ Q    S+ EE+ +LR
Sbjct: 1343 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1394


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 145/704 (20%), Positives = 308/704 (43%), Gaps = 81/704 (11%)

Query: 50   LSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEE 109
            L+   S     A  A  EL+     +  +D LR +  +++E+  +R+R+++        E
Sbjct: 2065 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSK--EQAELEAARQRQLAAEEERRRRE 2122

Query: 110  TNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQ 169
                    L        Q         K   EE+  +K K++      E  +Q+   Q Q
Sbjct: 2123 AEERVQKSLAAEEEAARQR--------KAALEEVERLKAKVEEARRLRERAEQESARQLQ 2174

Query: 170  EETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASA------GEQL 223
                  Q  L A    H ++    ++  + +T ++  S  +   G+A +A       E+ 
Sbjct: 2175 LAQEAAQKRLQAEEKAH-AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2233

Query: 224  ELEKLKLTYEEKCEIEESQ-LKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGL 282
             ++  +   + + ++EE++ LK    + A+ +   +   E+L+ +    AA         
Sbjct: 2234 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--- 2290

Query: 283  CLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQ 342
              + A  +   +      H +  E+ ++++  +   L ++R  L +T  ++    E++++
Sbjct: 2291 --QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2348

Query: 343  VLQISEEANFEKTKALIQCDQLRKEL---ERQAERLEKELAS-QQEKRAI---EKDMMKK 395
            +         E T+A  Q  Q+ +EL     Q E L K  A  + E RA+   +KD  ++
Sbjct: 2349 L-------KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401

Query: 396  EITKEREYM------GSKMLILSQ-----------NIAQLEAQVEKVTKEKISAINQLEE 438
             + +E E M       +++ + +Q           ++AQ  A  EK+ KEK+ A+ +   
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461

Query: 439  I--QSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEH---REFRAKTNRDLEIKDQEI 493
            +  +++L  ++ ++ +     R Q +K  M +  AE+     R   A+  R LE+   E 
Sbjct: 2462 LKAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEA 2519

Query: 494  EKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS--- 550
            E+L++ + E  +   + ++ A   R++     E +GE  H+  L  QEK ++ Q+     
Sbjct: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQA----EEIGEKLHRTELATQEKVTLVQTLEIQR 2575

Query: 551  ------KEAKAQALQAQQREQELTQ---KIQQMEAQHDKTENEQYLLLTSQNTFLTKLKE 601
                   E   +A+   +RE+E  Q   K+ Q++++  +T  ++ LL  +Q    + L E
Sbjct: 2576 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2635

Query: 602  ECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
            +   L +  E+  ++ ++++ QL Q++     +L + Q+R ++  EQ  +  R+  +M++
Sbjct: 2636 KDSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEE 2691

Query: 662  RLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
              R+  +  +   ++  +L   + Q   + + L+EE  RLR QL
Sbjct: 2692 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2735



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 148/716 (20%), Positives = 288/716 (40%), Gaps = 114/716 (15%)

Query: 74   VNQLKD----LLRQQADKESEVSPSRRRKM-SPLRSLEHEETNMPTMHDLVHTINDQ--- 125
            +N +KD    L+  +A  E   SP+++ K+ S   S+  E  ++ T +  + T+  Q   
Sbjct: 1413 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1472

Query: 126  --SQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASG 183
              S+ +  +E E +  +++ +  + ++  V    E  +Q  ++  Q +   E+   +   
Sbjct: 1473 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1532

Query: 184  NMHNSWITTGEDSGVGETSKRPFSHD--------NADFGKAASAGEQLELEKLKLTYE-- 233
             M    +   E +   +  KR    +         A+    A   E  E  +L++  E  
Sbjct: 1533 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592

Query: 234  ------------------------EKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEF 269
                                     + E  E+Q +  + +    +R  +D  ++ +  E 
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1652

Query: 270  LLAANT-------------CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLM 316
             LA+                  +  L L+  + E  L Q       Q    L   +    
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712

Query: 317  SALVSVRSSLAD-TQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERL 375
            + L S R+S A+ T Q E S  E+   V Q+ EEA   + +   + ++ R+E ER+ ER 
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE-RRAQQQAEAERAREEAERELERW 1771

Query: 376  E-------------KELASQQEKRAIEKDMMKKEITKEREYMG--SKMLILSQNIAQLEA 420
            +             +E+A Q+     E +  K+E  +E    G   +  +  + +A+ E 
Sbjct: 1772 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1831

Query: 421  Q-----VEKVTKEKISAINQLEEIQSQLASREMD---VTKVCGEMRYQLNKTNMEKDEAE 472
            +      E   +++++A  +L  ++++    E     + +    ++ +      ++ E E
Sbjct: 1832 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1891

Query: 473  KEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESE 532
             E  + RA+    L  K +  E+ R   ++SKQ LE E  +     EE  RL  L  E++
Sbjct: 1892 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951

Query: 533  HQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQM-EAQHDKTENEQYLL-LT 590
             Q  L  ++               A Q  + E+ L +K+  + EA   KTE E  L    
Sbjct: 1952 RQRQLAEED--------------AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1997

Query: 591  SQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNE-ELEEQC 649
            ++N  L +L E+     ++LE+          Q +Q K    ++L +L++ ++ ELE   
Sbjct: 1998 AENERLRRLAEDEAFQRRRLEE----------QAAQHKADIEERLAQLRKASDSELER-- 2045

Query: 650  VQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSL-SEEVDRLRTQ 704
             Q G V +T++QR RQ+++   A      +  + + +L LE   + S   D LR++
Sbjct: 2046 -QKGLVEDTLRQR-RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 2099



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 154/706 (21%), Positives = 294/706 (41%), Gaps = 88/706 (12%)

Query: 70   QSHAVNQLKDLLRQQADKESEVSPSRRRKMSP-----LRSLEHEETNMPTMHDLVHTIND 124
            Q+  V Q K L + +A+K+ E +    R+        +R  E  E  +     L      
Sbjct: 1784 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1843

Query: 125  Q----SQYIHHLEAEVK-------FCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETL 173
            Q     Q +  L AE +         +EEL+ ++ +      + + L+ +L   R E   
Sbjct: 1844 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-- 1901

Query: 174  REQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQL-----ELEKL 228
              + LL +            E     E SK+    +   F + A    +L     E ++ 
Sbjct: 1902 --EVLLASKARAEE------ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1953

Query: 229  KLTYEEKCEIEESQL-KFLRNDLA---EYQRTCEDLKEQLKHKEF------LLAANTCNR 278
            +   EE    + ++  + L   LA   E  R   + +  LK KE        LA +   +
Sbjct: 1954 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 2013

Query: 279  VGGLCLKCAQHEAVLSQTHTNVHMQT----------IERLVKERDDLMSALVSVRSSLAD 328
               L  + AQH+A + +    +   +          +E  +++R  +   ++++++S   
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 2073

Query: 329  TQQREASAYEQVKQVLQISEEANFEKTKALIQCD---QLRKELERQA----ERLEKELAS 381
                +A    ++ ++   +E+    K +A ++     QL  E ER+     ER++K LA+
Sbjct: 2074 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2133

Query: 382  QQE-----KRAIEK-DMMKKEITKER------EYMGSKMLILSQNIAQLEAQVEKVTKEK 429
            ++E     K A+E+ + +K ++ + R      E   ++ L L+Q  AQ   Q E+  K  
Sbjct: 2134 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE--KAH 2191

Query: 430  ISAINQLE-EIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEI 488
              A+ Q E E+Q  L   +  + ++ GE      +   E +EA  +     A++ R +E 
Sbjct: 2192 AFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQSRRQVE- 2249

Query: 489  KDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQS 548
               E E+L+   +E  Q   Q Q  A   R+E  +      ++E      +Q  D+  + 
Sbjct: 2250 ---EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2306

Query: 549  FSKEAKAQALQAQQREQELTQ-KIQQMEAQHDKT-ENEQYLLLTSQNTFL----TKLKEE 602
              K A+    Q  Q EQELT  ++Q  E  H K   +E+   L ++ T      ++++EE
Sbjct: 2307 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2366

Query: 603  CCTLAKKLEQISQ-KTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
              ++  ++E++S+ K R E    +   R   +    LQ   E++++   +  R+    ++
Sbjct: 2367 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2426

Query: 662  --RLRQLDKHSQATAQQLVQ-LLSKQNQLLLERQSLSEEVDRLRTQ 704
              RLRQL +   A  + L + +L ++ Q + E   L  E + L+ Q
Sbjct: 2427 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2472



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 90/404 (22%), Positives = 188/404 (46%), Gaps = 31/404 (7%)

Query: 327  ADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELA-SQQEK 385
            A+ ++R A     +++  Q++E     K +A  +  +L++ ++ +  R E+    +QQ+K
Sbjct: 1493 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1552

Query: 386  RAIEKDMMKKEITKEREYMGS---------KMLILSQNIAQLEAQVEKVTKEKISAINQL 436
            R+I++++ +   + E E               L + + I  +  Q+E   +++  A  +L
Sbjct: 1553 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1612

Query: 437  EEIQSQLASREMDVTKVCGE---MRYQLNKTNMEKDEAEKE---HREFRAKTNRDLEIKD 490
            + ++++    E    +   E   +R Q+   +  K +AE E     +  A+  R+ +   
Sbjct: 1613 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1672

Query: 491  QEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS 550
            Q +E+LR++ +E+++ L Q + + A   +  L   +   E+E Q       + + Q   S
Sbjct: 1673 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1732

Query: 551  KEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKL 610
             + +  A+ AQ RE+   +  QQ EA+  + E E+ L              E   L  + 
Sbjct: 1733 LQEEHVAV-AQLREEAERRAQQQAEAERAREEAERELERWQLKA------NEALRLRLQA 1785

Query: 611  EQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHS 670
            E+++Q+    +AQ   EK+   ++  +  RR  + EEQ V+   + E   ++ RQL + +
Sbjct: 1786 EEVAQQ--KSLAQAEAEKQK--EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1841

Query: 671  Q----ATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQ 710
                 A  Q+L++L ++  Q   +RQ L EE+ RL+ +  +  Q
Sbjct: 1842 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1885



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 133/652 (20%), Positives = 268/652 (41%), Gaps = 66/652 (10%)

Query: 68   LQQSH-AVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQS 126
            LQ+ H AV QL++   ++A +++E   +R       R LE  +        L     + +
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEAERAREEAE---RELERWQLKANEALRLRLQAEEVA 1789

Query: 127  QYIHHLEAEVKFCKEELSGMKNKI----QVVVLENEGLQQQLKSQRQEETLREQTLLDAS 182
            Q     +AE +  KEE      +     +  V + E  +Q+L+ QRQ      Q  L A 
Sbjct: 1790 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1849

Query: 183  GNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQ 242
              +    I    ++  GE  ++    + A   + A+A  Q   E      + + E+E   
Sbjct: 1850 QEL----IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1905

Query: 243  LKFLRNDLAEYQRTCEDLKEQLKHK--EFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNV 300
                R +  E + T E  K++L+ +   F   A    R+  L  + A+ +  L++     
Sbjct: 1906 ASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAAR 1963

Query: 301  HMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQ 360
                 ER++ E+   +     +++      + + +  E++++   ++E+  F++ +   Q
Sbjct: 1964 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQRRRLEEQ 2020

Query: 361  CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEA 420
              Q + ++E +  +L K   S+ E+   +K +++  + + R+        + + I  L+A
Sbjct: 2021 AAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQ--------VEEEILALKA 2069

Query: 421  QVEKVTKEKISAINQLEEIQSQ----LASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHR 476
              EK    K     +L  I+S     L S+E    +   + +    +    ++  E+  +
Sbjct: 2070 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2129

Query: 477  EFRAKTN--RDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQ 534
               A+    R  +   +E+E+L+ +++E+++  E+ +Q                 ES  Q
Sbjct: 2130 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ-----------------ESARQ 2172

Query: 535  LHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNT 594
            L L ++   + Q+    E KA A   QQ+EQEL Q +QQ ++  D+   E      +   
Sbjct: 2173 LQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA--- 2226

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQH-G 653
               +  EE    A++    S++   E  +L Q          + Q   E+L ++  Q   
Sbjct: 2227 --AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2284

Query: 654  RVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
            R  +  +  LRQ     QA   ++ +      Q L ++  + +E+  LR QL
Sbjct: 2285 RRAQAEQAALRQ----KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2332



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 114/514 (22%), Positives = 224/514 (43%), Gaps = 73/514 (14%)

Query: 224  ELEKLKLTYEE---KCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVG 280
            ELE  K + ++   + E ++     LR++L   Q   E L+++   ++ +       RV 
Sbjct: 1261 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD-VEVERWRERVA 1319

Query: 281  GLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQV 340
             L     + +AVL+QT  +V  + +E+L ++      +   + + L D ++R+    EQ+
Sbjct: 1320 QLL---ERWQAVLAQT--DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ----EQI 1370

Query: 341  KQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIEKDMMKKEITK 399
            + +     +A  E+ +   Q   L +E+ER  E++E+ +  ++Q   AI KD   + +T 
Sbjct: 1371 QAMPLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINAI-KDYELQLVTY 1426

Query: 400  EREYMGSKMLILSQNIAQLEAQVEKVTKEKI-----SAINQLEEIQ---SQLASREMDVT 451
            +               AQLE       K K+     S I +  +++   S+L +      
Sbjct: 1427 K---------------AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1471

Query: 452  KVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIE-----KLRIELDESKQH 506
            K   E   ++ +     ++   E RE  A+    LE + Q  E     K + E  E+K+ 
Sbjct: 1472 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKEL 1530

Query: 507  LEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQ- 565
             ++ Q       EE +R  E   +++ Q    ++E   ++QS   E +A+A QA+  E+ 
Sbjct: 1531 QQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1583

Query: 566  --ELTQKIQQMEAQHDKTENE--------QYLLLTSQNTFLTK--LKEECCTLAKKLEQI 613
               + ++I+ +  Q + TE +        Q L   ++     K   +EE   L ++++  
Sbjct: 1584 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643

Query: 614  SQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQAT 673
            SQ+ R    +L+   +   +   + QR  + LEE  +Q     E  ++RLRQ +      
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQ 1699

Query: 674  AQQLVQLL--SKQNQLLLERQSLSEEVDRLRTQL 705
             Q  ++    S + +L  +R S +E+  +L   L
Sbjct: 1700 VQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 88/443 (19%), Positives = 193/443 (43%), Gaps = 52/443 (11%)

Query: 222  QLELEKLKLTYEEKCEI-----EESQLKFL-RNDLAEYQRTCEDLKEQLKHKEFLLAANT 275
            Q E EK+K   EE   +     E ++L+ L   DLA+ +   E +      KE + A   
Sbjct: 2404 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-----KEKMQAVQE 2458

Query: 276  CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSV-----RSSLADTQ 330
              R+        + EA L Q    +  +   RL ++++ +   L        R+  A+ Q
Sbjct: 2459 ATRL--------KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510

Query: 331  QREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIE 389
            ++   + E  +  L+++E +  +  +A     + RK+ E   E+L + ELA+Q++   ++
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQ-ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2569

Query: 390  K-DMMKKEITKEREYMGSKMLILSQNIAQL--EAQVEKVTKEKISAINQLEEIQSQLASR 446
              ++ +++   + E +   +  L +   +L  EA++ ++  E++  + Q + +Q   A +
Sbjct: 2570 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2629

Query: 447  EMDVTK----VCGEMRYQLNKTNMEK---DEAEKEHREFRAKTNRDLEIKDQEIEKLRIE 499
            +  +++    +  E   +  K  +E+   DE  K  ++ R +  R  +  +QE ++L   
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-QQLREEQQRQQQQMEQERQRLVAS 2688

Query: 500  LDESKQHLEQEQQKAALAREECLRL-------TELLGESEHQLHLTRQ---EKDSIQQSF 549
            ++E+++   + ++     +EE  +L        ELL E   +L    Q   E+     + 
Sbjct: 2689 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2748

Query: 550  SKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKK 609
            S+E  A  + A    + L      ++    + E E       +     +L+E     A++
Sbjct: 2749 SEEVTASQVAA---TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2805

Query: 610  LEQISQ--KTRSEIAQLSQEKRY 630
            L++++Q   T  E+A+    + Y
Sbjct: 2806 LQRLAQGHTTVDELARREDVRHY 2828



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 80/412 (19%), Positives = 171/412 (41%), Gaps = 43/412 (10%)

Query: 326  LADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEK 385
            +A+ Q+ +A      K V ++S EA  EK  AL +       L  + E    +L   +  
Sbjct: 1160 IAEQQKAQAEVEGLGKGVARLSAEA--EKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1217

Query: 386  RAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAIN-QLEEIQSQLA 444
             AI  + +K      R   G++ ++ +      EAQ    T  ++ A    L+++++Q  
Sbjct: 1218 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1277

Query: 445  SREMDVTKVCGEMR------YQLNKTNMEKDEAEKEHREFRAKTNR-------DLEIKDQ 491
            +++     +  E+R       +L + + E+D   +  RE  A+            +++ +
Sbjct: 1278 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR 1337

Query: 492  EIEKLRIELD---ESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEK---DSI 545
            E+E+L  +L    ES   L    Q A   +E+   +   L +S+      RQE+   + I
Sbjct: 1338 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEI 1395

Query: 546  QQSFSKEAKAQALQAQ------QREQELTQKIQQME-----AQHDKTENEQYLLLTSQNT 594
            ++   K  + Q    Q        E +L     Q+E     A+  K ++    ++     
Sbjct: 1396 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD 1455

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGR 654
              T   E     ++ ++ IS+  R    ++ +E+R    +  + + R  E+E    +  +
Sbjct: 1456 LRTHYSELTTLTSQYIKFISETLR----RMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1511

Query: 655  VHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQ----SLSEEVDRLR 702
            + E   Q   Q ++ ++   Q++ + + ++ +  ++ Q    S+ EE+ +LR
Sbjct: 1512 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1563


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 145/704 (20%), Positives = 308/704 (43%), Gaps = 81/704 (11%)

Query: 50   LSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEE 109
            L+   S     A  A  EL+     +  +D LR +  +++E+  +R+R+++        E
Sbjct: 1906 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSK--EQAELEAARQRQLAAEEERRRRE 1963

Query: 110  TNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQ 169
                    L        Q         K   EE+  +K K++      E  +Q+   Q Q
Sbjct: 1964 AEERVQKSLAAEEEAARQR--------KAALEEVERLKAKVEEARRLRERAEQESARQLQ 2015

Query: 170  EETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASA------GEQL 223
                  Q  L A    H ++    ++  + +T ++  S  +   G+A +A       E+ 
Sbjct: 2016 LAQEAAQKRLQAEEKAH-AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2074

Query: 224  ELEKLKLTYEEKCEIEESQ-LKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGL 282
             ++  +   + + ++EE++ LK    + A+ +   +   E+L+ +    AA         
Sbjct: 2075 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--- 2131

Query: 283  CLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQ 342
              + A  +   +      H +  E+ ++++  +   L ++R  L +T  ++    E++++
Sbjct: 2132 --QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2189

Query: 343  VLQISEEANFEKTKALIQCDQLRKEL---ERQAERLEKELAS-QQEKRAI---EKDMMKK 395
            +         E T+A  Q  Q+ +EL     Q E L K  A  + E RA+   +KD  ++
Sbjct: 2190 L-------KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242

Query: 396  EITKEREYM------GSKMLILSQ-----------NIAQLEAQVEKVTKEKISAINQLEE 438
             + +E E M       +++ + +Q           ++AQ  A  EK+ KEK+ A+ +   
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302

Query: 439  I--QSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEH---REFRAKTNRDLEIKDQEI 493
            +  +++L  ++ ++ +     R Q +K  M +  AE+     R   A+  R LE+   E 
Sbjct: 2303 LKAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEA 2360

Query: 494  EKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS--- 550
            E+L++ + E  +   + ++ A   R++     E +GE  H+  L  QEK ++ Q+     
Sbjct: 2361 ERLKLRVAEMSRAQARAEEDAQRFRKQA----EEIGEKLHRTELATQEKVTLVQTLEIQR 2416

Query: 551  ------KEAKAQALQAQQREQELTQ---KIQQMEAQHDKTENEQYLLLTSQNTFLTKLKE 601
                   E   +A+   +RE+E  Q   K+ Q++++  +T  ++ LL  +Q    + L E
Sbjct: 2417 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2476

Query: 602  ECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
            +   L +  E+  ++ ++++ QL Q++     +L + Q+R ++  EQ  +  R+  +M++
Sbjct: 2477 KDSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEE 2532

Query: 662  RLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
              R+  +  +   ++  +L   + Q   + + L+EE  RLR QL
Sbjct: 2533 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2576



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 148/716 (20%), Positives = 288/716 (40%), Gaps = 114/716 (15%)

Query: 74   VNQLKD----LLRQQADKESEVSPSRRRKM-SPLRSLEHEETNMPTMHDLVHTINDQ--- 125
            +N +KD    L+  +A  E   SP+++ K+ S   S+  E  ++ T +  + T+  Q   
Sbjct: 1254 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1313

Query: 126  --SQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASG 183
              S+ +  +E E +  +++ +  + ++  V    E  +Q  ++  Q +   E+   +   
Sbjct: 1314 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1373

Query: 184  NMHNSWITTGEDSGVGETSKRPFSHD--------NADFGKAASAGEQLELEKLKLTYE-- 233
             M    +   E +   +  KR    +         A+    A   E  E  +L++  E  
Sbjct: 1374 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1433

Query: 234  ------------------------EKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEF 269
                                     + E  E+Q +  + +    +R  +D  ++ +  E 
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1493

Query: 270  LLAANT-------------CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLM 316
             LA+                  +  L L+  + E  L Q       Q    L   +    
Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553

Query: 317  SALVSVRSSLAD-TQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERL 375
            + L S R+S A+ T Q E S  E+   V Q+ EEA   + +   + ++ R+E ER+ ER 
Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE-RRAQQQAEAERAREEAERELERW 1612

Query: 376  E-------------KELASQQEKRAIEKDMMKKEITKEREYMG--SKMLILSQNIAQLEA 420
            +             +E+A Q+     E +  K+E  +E    G   +  +  + +A+ E 
Sbjct: 1613 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1672

Query: 421  Q-----VEKVTKEKISAINQLEEIQSQLASREMD---VTKVCGEMRYQLNKTNMEKDEAE 472
            +      E   +++++A  +L  ++++    E     + +    ++ +      ++ E E
Sbjct: 1673 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1732

Query: 473  KEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESE 532
             E  + RA+    L  K +  E+ R   ++SKQ LE E  +     EE  RL  L  E++
Sbjct: 1733 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792

Query: 533  HQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQM-EAQHDKTENEQYLL-LT 590
             Q  L  ++               A Q  + E+ L +K+  + EA   KTE E  L    
Sbjct: 1793 RQRQLAEED--------------AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1838

Query: 591  SQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNE-ELEEQC 649
            ++N  L +L E+     ++LE+          Q +Q K    ++L +L++ ++ ELE   
Sbjct: 1839 AENERLRRLAEDEAFQRRRLEE----------QAAQHKADIEERLAQLRKASDSELER-- 1886

Query: 650  VQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSL-SEEVDRLRTQ 704
             Q G V +T++QR RQ+++   A      +  + + +L LE   + S   D LR++
Sbjct: 1887 -QKGLVEDTLRQR-RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1940



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 154/706 (21%), Positives = 294/706 (41%), Gaps = 88/706 (12%)

Query: 70   QSHAVNQLKDLLRQQADKESEVSPSRRRKMSP-----LRSLEHEETNMPTMHDLVHTIND 124
            Q+  V Q K L + +A+K+ E +    R+        +R  E  E  +     L      
Sbjct: 1625 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1684

Query: 125  Q----SQYIHHLEAEVK-------FCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETL 173
            Q     Q +  L AE +         +EEL+ ++ +      + + L+ +L   R E   
Sbjct: 1685 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-- 1742

Query: 174  REQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQL-----ELEKL 228
              + LL +            E     E SK+    +   F + A    +L     E ++ 
Sbjct: 1743 --EVLLASKARAEE------ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1794

Query: 229  KLTYEEKCEIEESQL-KFLRNDLA---EYQRTCEDLKEQLKHKEF------LLAANTCNR 278
            +   EE    + ++  + L   LA   E  R   + +  LK KE        LA +   +
Sbjct: 1795 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1854

Query: 279  VGGLCLKCAQHEAVLSQTHTNVHMQT----------IERLVKERDDLMSALVSVRSSLAD 328
               L  + AQH+A + +    +   +          +E  +++R  +   ++++++S   
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1914

Query: 329  TQQREASAYEQVKQVLQISEEANFEKTKALIQCD---QLRKELERQA----ERLEKELAS 381
                +A    ++ ++   +E+    K +A ++     QL  E ER+     ER++K LA+
Sbjct: 1915 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1974

Query: 382  QQE-----KRAIEK-DMMKKEITKER------EYMGSKMLILSQNIAQLEAQVEKVTKEK 429
            ++E     K A+E+ + +K ++ + R      E   ++ L L+Q  AQ   Q E+  K  
Sbjct: 1975 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE--KAH 2032

Query: 430  ISAINQLE-EIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEI 488
              A+ Q E E+Q  L   +  + ++ GE      +   E +EA  +     A++ R +E 
Sbjct: 2033 AFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQSRRQVE- 2090

Query: 489  KDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQS 548
               E E+L+   +E  Q   Q Q  A   R+E  +      ++E      +Q  D+  + 
Sbjct: 2091 ---EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2147

Query: 549  FSKEAKAQALQAQQREQELTQ-KIQQMEAQHDKT-ENEQYLLLTSQNTFL----TKLKEE 602
              K A+    Q  Q EQELT  ++Q  E  H K   +E+   L ++ T      ++++EE
Sbjct: 2148 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2207

Query: 603  CCTLAKKLEQISQ-KTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
              ++  ++E++S+ K R E    +   R   +    LQ   E++++   +  R+    ++
Sbjct: 2208 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2267

Query: 662  --RLRQLDKHSQATAQQLVQ-LLSKQNQLLLERQSLSEEVDRLRTQ 704
              RLRQL +   A  + L + +L ++ Q + E   L  E + L+ Q
Sbjct: 2268 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2313



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 90/404 (22%), Positives = 188/404 (46%), Gaps = 31/404 (7%)

Query: 327  ADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELA-SQQEK 385
            A+ ++R A     +++  Q++E     K +A  +  +L++ ++ +  R E+    +QQ+K
Sbjct: 1334 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1393

Query: 386  RAIEKDMMKKEITKEREYMGS---------KMLILSQNIAQLEAQVEKVTKEKISAINQL 436
            R+I++++ +   + E E               L + + I  +  Q+E   +++  A  +L
Sbjct: 1394 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1453

Query: 437  EEIQSQLASREMDVTKVCGE---MRYQLNKTNMEKDEAEKE---HREFRAKTNRDLEIKD 490
            + ++++    E    +   E   +R Q+   +  K +AE E     +  A+  R+ +   
Sbjct: 1454 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1513

Query: 491  QEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS 550
            Q +E+LR++ +E+++ L Q + + A   +  L   +   E+E Q       + + Q   S
Sbjct: 1514 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1573

Query: 551  KEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKL 610
             + +  A+ AQ RE+   +  QQ EA+  + E E+ L              E   L  + 
Sbjct: 1574 LQEEHVAV-AQLREEAERRAQQQAEAERAREEAERELERWQLKA------NEALRLRLQA 1626

Query: 611  EQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHS 670
            E+++Q+    +AQ   EK+   ++  +  RR  + EEQ V+   + E   ++ RQL + +
Sbjct: 1627 EEVAQQ--KSLAQAEAEKQK--EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1682

Query: 671  Q----ATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQ 710
                 A  Q+L++L ++  Q   +RQ L EE+ RL+ +  +  Q
Sbjct: 1683 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1726



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 133/652 (20%), Positives = 268/652 (41%), Gaps = 66/652 (10%)

Query: 68   LQQSH-AVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQS 126
            LQ+ H AV QL++   ++A +++E   +R       R LE  +        L     + +
Sbjct: 1574 LQEEHVAVAQLREEAERRAQQQAEAERAREEAE---RELERWQLKANEALRLRLQAEEVA 1630

Query: 127  QYIHHLEAEVKFCKEELSGMKNKI----QVVVLENEGLQQQLKSQRQEETLREQTLLDAS 182
            Q     +AE +  KEE      +     +  V + E  +Q+L+ QRQ      Q  L A 
Sbjct: 1631 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1690

Query: 183  GNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQ 242
              +    I    ++  GE  ++    + A   + A+A  Q   E      + + E+E   
Sbjct: 1691 QEL----IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1746

Query: 243  LKFLRNDLAEYQRTCEDLKEQLKHK--EFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNV 300
                R +  E + T E  K++L+ +   F   A    R+  L  + A+ +  L++     
Sbjct: 1747 ASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAAR 1804

Query: 301  HMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQ 360
                 ER++ E+   +     +++      + + +  E++++   ++E+  F++ +   Q
Sbjct: 1805 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQRRRLEEQ 1861

Query: 361  CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEA 420
              Q + ++E +  +L K   S+ E+   +K +++  + + R+        + + I  L+A
Sbjct: 1862 AAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQ--------VEEEILALKA 1910

Query: 421  QVEKVTKEKISAINQLEEIQSQ----LASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHR 476
              EK    K     +L  I+S     L S+E    +   + +    +    ++  E+  +
Sbjct: 1911 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1970

Query: 477  EFRAKTN--RDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQ 534
               A+    R  +   +E+E+L+ +++E+++  E+ +Q                 ES  Q
Sbjct: 1971 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ-----------------ESARQ 2013

Query: 535  LHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNT 594
            L L ++   + Q+    E KA A   QQ+EQEL Q +QQ ++  D+   E      +   
Sbjct: 2014 LQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA--- 2067

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQH-G 653
               +  EE    A++    S++   E  +L Q          + Q   E+L ++  Q   
Sbjct: 2068 --AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2125

Query: 654  RVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
            R  +  +  LRQ     QA   ++ +      Q L ++  + +E+  LR QL
Sbjct: 2126 RRAQAEQAALRQ----KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2173



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 114/514 (22%), Positives = 224/514 (43%), Gaps = 73/514 (14%)

Query: 224  ELEKLKLTYEE---KCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVG 280
            ELE  K + ++   + E ++     LR++L   Q   E L+++   ++ +       RV 
Sbjct: 1102 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD-VEVERWRERVA 1160

Query: 281  GLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQV 340
             L     + +AVL+QT  +V  + +E+L ++      +   + + L D ++R+    EQ+
Sbjct: 1161 QLL---ERWQAVLAQT--DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ----EQI 1211

Query: 341  KQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIEKDMMKKEITK 399
            + +     +A  E+ +   Q   L +E+ER  E++E+ +  ++Q   AI KD   + +T 
Sbjct: 1212 QAMPLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINAI-KDYELQLVTY 1267

Query: 400  EREYMGSKMLILSQNIAQLEAQVEKVTKEKI-----SAINQLEEIQ---SQLASREMDVT 451
            +               AQLE       K K+     S I +  +++   S+L +      
Sbjct: 1268 K---------------AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1312

Query: 452  KVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIE-----KLRIELDESKQH 506
            K   E   ++ +     ++   E RE  A+    LE + Q  E     K + E  E+K+ 
Sbjct: 1313 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKEL 1371

Query: 507  LEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQ- 565
             ++ Q       EE +R  E   +++ Q    ++E   ++QS   E +A+A QA+  E+ 
Sbjct: 1372 QQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1424

Query: 566  --ELTQKIQQMEAQHDKTENE--------QYLLLTSQNTFLTK--LKEECCTLAKKLEQI 613
               + ++I+ +  Q + TE +        Q L   ++     K   +EE   L ++++  
Sbjct: 1425 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484

Query: 614  SQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQAT 673
            SQ+ R    +L+   +   +   + QR  + LEE  +Q     E  ++RLRQ +      
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQ 1540

Query: 674  AQQLVQLL--SKQNQLLLERQSLSEEVDRLRTQL 705
             Q  ++    S + +L  +R S +E+  +L   L
Sbjct: 1541 VQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 88/443 (19%), Positives = 193/443 (43%), Gaps = 52/443 (11%)

Query: 222  QLELEKLKLTYEEKCEI-----EESQLKFL-RNDLAEYQRTCEDLKEQLKHKEFLLAANT 275
            Q E EK+K   EE   +     E ++L+ L   DLA+ +   E +      KE + A   
Sbjct: 2245 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-----KEKMQAVQE 2299

Query: 276  CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSV-----RSSLADTQ 330
              R+        + EA L Q    +  +   RL ++++ +   L        R+  A+ Q
Sbjct: 2300 ATRL--------KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351

Query: 331  QREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIE 389
            ++   + E  +  L+++E +  +  +A     + RK+ E   E+L + ELA+Q++   ++
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQ-ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2410

Query: 390  K-DMMKKEITKEREYMGSKMLILSQNIAQL--EAQVEKVTKEKISAINQLEEIQSQLASR 446
              ++ +++   + E +   +  L +   +L  EA++ ++  E++  + Q + +Q   A +
Sbjct: 2411 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2470

Query: 447  EMDVTK----VCGEMRYQLNKTNMEK---DEAEKEHREFRAKTNRDLEIKDQEIEKLRIE 499
            +  +++    +  E   +  K  +E+   DE  K  ++ R +  R  +  +QE ++L   
Sbjct: 2471 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-QQLREEQQRQQQQMEQERQRLVAS 2529

Query: 500  LDESKQHLEQEQQKAALAREECLRL-------TELLGESEHQLHLTRQ---EKDSIQQSF 549
            ++E+++   + ++     +EE  +L        ELL E   +L    Q   E+     + 
Sbjct: 2530 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2589

Query: 550  SKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKK 609
            S+E  A  + A    + L      ++    + E E       +     +L+E     A++
Sbjct: 2590 SEEVTASQVAA---TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2646

Query: 610  LEQISQ--KTRSEIAQLSQEKRY 630
            L++++Q   T  E+A+    + Y
Sbjct: 2647 LQRLAQGHTTVDELARREDVRHY 2669



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 80/412 (19%), Positives = 171/412 (41%), Gaps = 43/412 (10%)

Query: 326  LADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEK 385
            +A+ Q+ +A      K V ++S EA  EK  AL +       L  + E    +L   +  
Sbjct: 1001 IAEQQKAQAEVEGLGKGVARLSAEA--EKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1058

Query: 386  RAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAIN-QLEEIQSQLA 444
             AI  + +K      R   G++ ++ +      EAQ    T  ++ A    L+++++Q  
Sbjct: 1059 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1118

Query: 445  SREMDVTKVCGEMR------YQLNKTNMEKDEAEKEHREFRAKTNR-------DLEIKDQ 491
            +++     +  E+R       +L + + E+D   +  RE  A+            +++ +
Sbjct: 1119 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR 1178

Query: 492  EIEKLRIELD---ESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEK---DSI 545
            E+E+L  +L    ES   L    Q A   +E+   +   L +S+      RQE+   + I
Sbjct: 1179 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEI 1236

Query: 546  QQSFSKEAKAQALQAQ------QREQELTQKIQQME-----AQHDKTENEQYLLLTSQNT 594
            ++   K  + Q    Q        E +L     Q+E     A+  K ++    ++     
Sbjct: 1237 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD 1296

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGR 654
              T   E     ++ ++ IS+  R    ++ +E+R    +  + + R  E+E    +  +
Sbjct: 1297 LRTHYSELTTLTSQYIKFISETLR----RMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1352

Query: 655  VHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQ----SLSEEVDRLR 702
            + E   Q   Q ++ ++   Q++ + + ++ +  ++ Q    S+ EE+ +LR
Sbjct: 1353 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1404


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 145/704 (20%), Positives = 308/704 (43%), Gaps = 81/704 (11%)

Query: 50   LSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEE 109
            L+   S     A  A  EL+     +  +D LR +  +++E+  +R+R+++        E
Sbjct: 1914 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSK--EQAELEAARQRQLAAEEERRRRE 1971

Query: 110  TNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQ 169
                    L        Q         K   EE+  +K K++      E  +Q+   Q Q
Sbjct: 1972 AEERVQKSLAAEEEAARQR--------KAALEEVERLKAKVEEARRLRERAEQESARQLQ 2023

Query: 170  EETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASA------GEQL 223
                  Q  L A    H ++    ++  + +T ++  S  +   G+A +A       E+ 
Sbjct: 2024 LAQEAAQKRLQAEEKAH-AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2082

Query: 224  ELEKLKLTYEEKCEIEESQ-LKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGL 282
             ++  +   + + ++EE++ LK    + A+ +   +   E+L+ +    AA         
Sbjct: 2083 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--- 2139

Query: 283  CLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQ 342
              + A  +   +      H +  E+ ++++  +   L ++R  L +T  ++    E++++
Sbjct: 2140 --QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2197

Query: 343  VLQISEEANFEKTKALIQCDQLRKEL---ERQAERLEKELAS-QQEKRAI---EKDMMKK 395
            +         E T+A  Q  Q+ +EL     Q E L K  A  + E RA+   +KD  ++
Sbjct: 2198 L-------KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250

Query: 396  EITKEREYM------GSKMLILSQ-----------NIAQLEAQVEKVTKEKISAINQLEE 438
             + +E E M       +++ + +Q           ++AQ  A  EK+ KEK+ A+ +   
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310

Query: 439  I--QSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEH---REFRAKTNRDLEIKDQEI 493
            +  +++L  ++ ++ +     R Q +K  M +  AE+     R   A+  R LE+   E 
Sbjct: 2311 LKAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEA 2368

Query: 494  EKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS--- 550
            E+L++ + E  +   + ++ A   R++     E +GE  H+  L  QEK ++ Q+     
Sbjct: 2369 ERLKLRVAEMSRAQARAEEDAQRFRKQA----EEIGEKLHRTELATQEKVTLVQTLEIQR 2424

Query: 551  ------KEAKAQALQAQQREQELTQ---KIQQMEAQHDKTENEQYLLLTSQNTFLTKLKE 601
                   E   +A+   +RE+E  Q   K+ Q++++  +T  ++ LL  +Q    + L E
Sbjct: 2425 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2484

Query: 602  ECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
            +   L +  E+  ++ ++++ QL Q++     +L + Q+R ++  EQ  +  R+  +M++
Sbjct: 2485 KDSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEE 2540

Query: 662  RLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
              R+  +  +   ++  +L   + Q   + + L+EE  RLR QL
Sbjct: 2541 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2584



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 148/716 (20%), Positives = 288/716 (40%), Gaps = 114/716 (15%)

Query: 74   VNQLKD----LLRQQADKESEVSPSRRRKM-SPLRSLEHEETNMPTMHDLVHTINDQ--- 125
            +N +KD    L+  +A  E   SP+++ K+ S   S+  E  ++ T +  + T+  Q   
Sbjct: 1262 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1321

Query: 126  --SQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASG 183
              S+ +  +E E +  +++ +  + ++  V    E  +Q  ++  Q +   E+   +   
Sbjct: 1322 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1381

Query: 184  NMHNSWITTGEDSGVGETSKRPFSHD--------NADFGKAASAGEQLELEKLKLTYE-- 233
             M    +   E +   +  KR    +         A+    A   E  E  +L++  E  
Sbjct: 1382 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1441

Query: 234  ------------------------EKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEF 269
                                     + E  E+Q +  + +    +R  +D  ++ +  E 
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1501

Query: 270  LLAANT-------------CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLM 316
             LA+                  +  L L+  + E  L Q       Q    L   +    
Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561

Query: 317  SALVSVRSSLAD-TQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERL 375
            + L S R+S A+ T Q E S  E+   V Q+ EEA   + +   + ++ R+E ER+ ER 
Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE-RRAQQQAEAERAREEAERELERW 1620

Query: 376  E-------------KELASQQEKRAIEKDMMKKEITKEREYMG--SKMLILSQNIAQLEA 420
            +             +E+A Q+     E +  K+E  +E    G   +  +  + +A+ E 
Sbjct: 1621 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1680

Query: 421  Q-----VEKVTKEKISAINQLEEIQSQLASREMD---VTKVCGEMRYQLNKTNMEKDEAE 472
            +      E   +++++A  +L  ++++    E     + +    ++ +      ++ E E
Sbjct: 1681 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1740

Query: 473  KEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESE 532
             E  + RA+    L  K +  E+ R   ++SKQ LE E  +     EE  RL  L  E++
Sbjct: 1741 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800

Query: 533  HQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQM-EAQHDKTENEQYLL-LT 590
             Q  L  ++               A Q  + E+ L +K+  + EA   KTE E  L    
Sbjct: 1801 RQRQLAEED--------------AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1846

Query: 591  SQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNE-ELEEQC 649
            ++N  L +L E+     ++LE+          Q +Q K    ++L +L++ ++ ELE   
Sbjct: 1847 AENERLRRLAEDEAFQRRRLEE----------QAAQHKADIEERLAQLRKASDSELER-- 1894

Query: 650  VQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSL-SEEVDRLRTQ 704
             Q G V +T++QR RQ+++   A      +  + + +L LE   + S   D LR++
Sbjct: 1895 -QKGLVEDTLRQR-RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1948



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 154/706 (21%), Positives = 294/706 (41%), Gaps = 88/706 (12%)

Query: 70   QSHAVNQLKDLLRQQADKESEVSPSRRRKMSP-----LRSLEHEETNMPTMHDLVHTIND 124
            Q+  V Q K L + +A+K+ E +    R+        +R  E  E  +     L      
Sbjct: 1633 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1692

Query: 125  Q----SQYIHHLEAEVK-------FCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETL 173
            Q     Q +  L AE +         +EEL+ ++ +      + + L+ +L   R E   
Sbjct: 1693 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-- 1750

Query: 174  REQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQL-----ELEKL 228
              + LL +            E     E SK+    +   F + A    +L     E ++ 
Sbjct: 1751 --EVLLASKARAEE------ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1802

Query: 229  KLTYEEKCEIEESQL-KFLRNDLA---EYQRTCEDLKEQLKHKEF------LLAANTCNR 278
            +   EE    + ++  + L   LA   E  R   + +  LK KE        LA +   +
Sbjct: 1803 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1862

Query: 279  VGGLCLKCAQHEAVLSQTHTNVHMQT----------IERLVKERDDLMSALVSVRSSLAD 328
               L  + AQH+A + +    +   +          +E  +++R  +   ++++++S   
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1922

Query: 329  TQQREASAYEQVKQVLQISEEANFEKTKALIQCD---QLRKELERQA----ERLEKELAS 381
                +A    ++ ++   +E+    K +A ++     QL  E ER+     ER++K LA+
Sbjct: 1923 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1982

Query: 382  QQE-----KRAIEK-DMMKKEITKER------EYMGSKMLILSQNIAQLEAQVEKVTKEK 429
            ++E     K A+E+ + +K ++ + R      E   ++ L L+Q  AQ   Q E+  K  
Sbjct: 1983 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE--KAH 2040

Query: 430  ISAINQLE-EIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEI 488
              A+ Q E E+Q  L   +  + ++ GE      +   E +EA  +     A++ R +E 
Sbjct: 2041 AFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQSRRQVE- 2098

Query: 489  KDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQS 548
               E E+L+   +E  Q   Q Q  A   R+E  +      ++E      +Q  D+  + 
Sbjct: 2099 ---EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2155

Query: 549  FSKEAKAQALQAQQREQELTQ-KIQQMEAQHDKT-ENEQYLLLTSQNTFL----TKLKEE 602
              K A+    Q  Q EQELT  ++Q  E  H K   +E+   L ++ T      ++++EE
Sbjct: 2156 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2215

Query: 603  CCTLAKKLEQISQ-KTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
              ++  ++E++S+ K R E    +   R   +    LQ   E++++   +  R+    ++
Sbjct: 2216 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2275

Query: 662  --RLRQLDKHSQATAQQLVQ-LLSKQNQLLLERQSLSEEVDRLRTQ 704
              RLRQL +   A  + L + +L ++ Q + E   L  E + L+ Q
Sbjct: 2276 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2321



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 90/404 (22%), Positives = 188/404 (46%), Gaps = 31/404 (7%)

Query: 327  ADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELA-SQQEK 385
            A+ ++R A     +++  Q++E     K +A  +  +L++ ++ +  R E+    +QQ+K
Sbjct: 1342 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1401

Query: 386  RAIEKDMMKKEITKEREYMGS---------KMLILSQNIAQLEAQVEKVTKEKISAINQL 436
            R+I++++ +   + E E               L + + I  +  Q+E   +++  A  +L
Sbjct: 1402 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1461

Query: 437  EEIQSQLASREMDVTKVCGE---MRYQLNKTNMEKDEAEKE---HREFRAKTNRDLEIKD 490
            + ++++    E    +   E   +R Q+   +  K +AE E     +  A+  R+ +   
Sbjct: 1462 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1521

Query: 491  QEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS 550
            Q +E+LR++ +E+++ L Q + + A   +  L   +   E+E Q       + + Q   S
Sbjct: 1522 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1581

Query: 551  KEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKL 610
             + +  A+ AQ RE+   +  QQ EA+  + E E+ L              E   L  + 
Sbjct: 1582 LQEEHVAV-AQLREEAERRAQQQAEAERAREEAERELERWQLKA------NEALRLRLQA 1634

Query: 611  EQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHS 670
            E+++Q+    +AQ   EK+   ++  +  RR  + EEQ V+   + E   ++ RQL + +
Sbjct: 1635 EEVAQQ--KSLAQAEAEKQK--EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1690

Query: 671  Q----ATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQ 710
                 A  Q+L++L ++  Q   +RQ L EE+ RL+ +  +  Q
Sbjct: 1691 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1734



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 133/652 (20%), Positives = 268/652 (41%), Gaps = 66/652 (10%)

Query: 68   LQQSH-AVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQS 126
            LQ+ H AV QL++   ++A +++E   +R       R LE  +        L     + +
Sbjct: 1582 LQEEHVAVAQLREEAERRAQQQAEAERAREEAE---RELERWQLKANEALRLRLQAEEVA 1638

Query: 127  QYIHHLEAEVKFCKEELSGMKNKI----QVVVLENEGLQQQLKSQRQEETLREQTLLDAS 182
            Q     +AE +  KEE      +     +  V + E  +Q+L+ QRQ      Q  L A 
Sbjct: 1639 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1698

Query: 183  GNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQ 242
              +    I    ++  GE  ++    + A   + A+A  Q   E      + + E+E   
Sbjct: 1699 QEL----IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1754

Query: 243  LKFLRNDLAEYQRTCEDLKEQLKHK--EFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNV 300
                R +  E + T E  K++L+ +   F   A    R+  L  + A+ +  L++     
Sbjct: 1755 ASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAAR 1812

Query: 301  HMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQ 360
                 ER++ E+   +     +++      + + +  E++++   ++E+  F++ +   Q
Sbjct: 1813 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQRRRLEEQ 1869

Query: 361  CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEA 420
              Q + ++E +  +L K   S+ E+   +K +++  + + R+        + + I  L+A
Sbjct: 1870 AAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQ--------VEEEILALKA 1918

Query: 421  QVEKVTKEKISAINQLEEIQSQ----LASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHR 476
              EK    K     +L  I+S     L S+E    +   + +    +    ++  E+  +
Sbjct: 1919 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1978

Query: 477  EFRAKTN--RDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQ 534
               A+    R  +   +E+E+L+ +++E+++  E+ +Q                 ES  Q
Sbjct: 1979 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ-----------------ESARQ 2021

Query: 535  LHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNT 594
            L L ++   + Q+    E KA A   QQ+EQEL Q +QQ ++  D+   E      +   
Sbjct: 2022 LQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA--- 2075

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQH-G 653
               +  EE    A++    S++   E  +L Q          + Q   E+L ++  Q   
Sbjct: 2076 --AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2133

Query: 654  RVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
            R  +  +  LRQ     QA   ++ +      Q L ++  + +E+  LR QL
Sbjct: 2134 RRAQAEQAALRQ----KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2181



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 114/514 (22%), Positives = 224/514 (43%), Gaps = 73/514 (14%)

Query: 224  ELEKLKLTYEE---KCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVG 280
            ELE  K + ++   + E ++     LR++L   Q   E L+++   ++ +       RV 
Sbjct: 1110 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD-VEVERWRERVA 1168

Query: 281  GLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQV 340
             L     + +AVL+QT  +V  + +E+L ++      +   + + L D ++R+    EQ+
Sbjct: 1169 QLL---ERWQAVLAQT--DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ----EQI 1219

Query: 341  KQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIEKDMMKKEITK 399
            + +     +A  E+ +   Q   L +E+ER  E++E+ +  ++Q   AI KD   + +T 
Sbjct: 1220 QAMPLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINAI-KDYELQLVTY 1275

Query: 400  EREYMGSKMLILSQNIAQLEAQVEKVTKEKI-----SAINQLEEIQ---SQLASREMDVT 451
            +               AQLE       K K+     S I +  +++   S+L +      
Sbjct: 1276 K---------------AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1320

Query: 452  KVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIE-----KLRIELDESKQH 506
            K   E   ++ +     ++   E RE  A+    LE + Q  E     K + E  E+K+ 
Sbjct: 1321 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKEL 1379

Query: 507  LEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQ- 565
             ++ Q       EE +R  E   +++ Q    ++E   ++QS   E +A+A QA+  E+ 
Sbjct: 1380 QQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1432

Query: 566  --ELTQKIQQMEAQHDKTENE--------QYLLLTSQNTFLTK--LKEECCTLAKKLEQI 613
               + ++I+ +  Q + TE +        Q L   ++     K   +EE   L ++++  
Sbjct: 1433 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492

Query: 614  SQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQAT 673
            SQ+ R    +L+   +   +   + QR  + LEE  +Q     E  ++RLRQ +      
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQ 1548

Query: 674  AQQLVQLL--SKQNQLLLERQSLSEEVDRLRTQL 705
             Q  ++    S + +L  +R S +E+  +L   L
Sbjct: 1549 VQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 88/443 (19%), Positives = 193/443 (43%), Gaps = 52/443 (11%)

Query: 222  QLELEKLKLTYEEKCEI-----EESQLKFL-RNDLAEYQRTCEDLKEQLKHKEFLLAANT 275
            Q E EK+K   EE   +     E ++L+ L   DLA+ +   E +      KE + A   
Sbjct: 2253 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-----KEKMQAVQE 2307

Query: 276  CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSV-----RSSLADTQ 330
              R+        + EA L Q    +  +   RL ++++ +   L        R+  A+ Q
Sbjct: 2308 ATRL--------KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359

Query: 331  QREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIE 389
            ++   + E  +  L+++E +  +  +A     + RK+ E   E+L + ELA+Q++   ++
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQ-ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2418

Query: 390  K-DMMKKEITKEREYMGSKMLILSQNIAQL--EAQVEKVTKEKISAINQLEEIQSQLASR 446
              ++ +++   + E +   +  L +   +L  EA++ ++  E++  + Q + +Q   A +
Sbjct: 2419 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2478

Query: 447  EMDVTK----VCGEMRYQLNKTNMEK---DEAEKEHREFRAKTNRDLEIKDQEIEKLRIE 499
            +  +++    +  E   +  K  +E+   DE  K  ++ R +  R  +  +QE ++L   
Sbjct: 2479 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-QQLREEQQRQQQQMEQERQRLVAS 2537

Query: 500  LDESKQHLEQEQQKAALAREECLRL-------TELLGESEHQLHLTRQ---EKDSIQQSF 549
            ++E+++   + ++     +EE  +L        ELL E   +L    Q   E+     + 
Sbjct: 2538 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2597

Query: 550  SKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKK 609
            S+E  A  + A    + L      ++    + E E       +     +L+E     A++
Sbjct: 2598 SEEVTASQVAA---TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2654

Query: 610  LEQISQ--KTRSEIAQLSQEKRY 630
            L++++Q   T  E+A+    + Y
Sbjct: 2655 LQRLAQGHTTVDELARREDVRHY 2677



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 80/412 (19%), Positives = 171/412 (41%), Gaps = 43/412 (10%)

Query: 326  LADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEK 385
            +A+ Q+ +A      K V ++S EA  EK  AL +       L  + E    +L   +  
Sbjct: 1009 IAEQQKAQAEVEGLGKGVARLSAEA--EKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1066

Query: 386  RAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAIN-QLEEIQSQLA 444
             AI  + +K      R   G++ ++ +      EAQ    T  ++ A    L+++++Q  
Sbjct: 1067 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1126

Query: 445  SREMDVTKVCGEMR------YQLNKTNMEKDEAEKEHREFRAKTNR-------DLEIKDQ 491
            +++     +  E+R       +L + + E+D   +  RE  A+            +++ +
Sbjct: 1127 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR 1186

Query: 492  EIEKLRIELD---ESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEK---DSI 545
            E+E+L  +L    ES   L    Q A   +E+   +   L +S+      RQE+   + I
Sbjct: 1187 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEI 1244

Query: 546  QQSFSKEAKAQALQAQ------QREQELTQKIQQME-----AQHDKTENEQYLLLTSQNT 594
            ++   K  + Q    Q        E +L     Q+E     A+  K ++    ++     
Sbjct: 1245 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD 1304

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGR 654
              T   E     ++ ++ IS+  R    ++ +E+R    +  + + R  E+E    +  +
Sbjct: 1305 LRTHYSELTTLTSQYIKFISETLR----RMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1360

Query: 655  VHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQ----SLSEEVDRLR 702
            + E   Q   Q ++ ++   Q++ + + ++ +  ++ Q    S+ EE+ +LR
Sbjct: 1361 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1412


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 145/704 (20%), Positives = 308/704 (43%), Gaps = 81/704 (11%)

Query: 50   LSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEE 109
            L+   S     A  A  EL+     +  +D LR +  +++E+  +R+R+++        E
Sbjct: 1955 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSK--EQAELEAARQRQLAAEEERRRRE 2012

Query: 110  TNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQ 169
                    L        Q         K   EE+  +K K++      E  +Q+   Q Q
Sbjct: 2013 AEERVQKSLAAEEEAARQR--------KAALEEVERLKAKVEEARRLRERAEQESARQLQ 2064

Query: 170  EETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASA------GEQL 223
                  Q  L A    H ++    ++  + +T ++  S  +   G+A +A       E+ 
Sbjct: 2065 LAQEAAQKRLQAEEKAH-AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2123

Query: 224  ELEKLKLTYEEKCEIEESQ-LKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGL 282
             ++  +   + + ++EE++ LK    + A+ +   +   E+L+ +    AA         
Sbjct: 2124 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--- 2180

Query: 283  CLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQ 342
              + A  +   +      H +  E+ ++++  +   L ++R  L +T  ++    E++++
Sbjct: 2181 --QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2238

Query: 343  VLQISEEANFEKTKALIQCDQLRKEL---ERQAERLEKELAS-QQEKRAI---EKDMMKK 395
            +         E T+A  Q  Q+ +EL     Q E L K  A  + E RA+   +KD  ++
Sbjct: 2239 L-------KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291

Query: 396  EITKEREYM------GSKMLILSQ-----------NIAQLEAQVEKVTKEKISAINQLEE 438
             + +E E M       +++ + +Q           ++AQ  A  EK+ KEK+ A+ +   
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351

Query: 439  I--QSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEH---REFRAKTNRDLEIKDQEI 493
            +  +++L  ++ ++ +     R Q +K  M +  AE+     R   A+  R LE+   E 
Sbjct: 2352 LKAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEA 2409

Query: 494  EKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS--- 550
            E+L++ + E  +   + ++ A   R++     E +GE  H+  L  QEK ++ Q+     
Sbjct: 2410 ERLKLRVAEMSRAQARAEEDAQRFRKQA----EEIGEKLHRTELATQEKVTLVQTLEIQR 2465

Query: 551  ------KEAKAQALQAQQREQELTQ---KIQQMEAQHDKTENEQYLLLTSQNTFLTKLKE 601
                   E   +A+   +RE+E  Q   K+ Q++++  +T  ++ LL  +Q    + L E
Sbjct: 2466 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2525

Query: 602  ECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
            +   L +  E+  ++ ++++ QL Q++     +L + Q+R ++  EQ  +  R+  +M++
Sbjct: 2526 KDSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEE 2581

Query: 662  RLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
              R+  +  +   ++  +L   + Q   + + L+EE  RLR QL
Sbjct: 2582 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2625



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 148/716 (20%), Positives = 288/716 (40%), Gaps = 114/716 (15%)

Query: 74   VNQLKD----LLRQQADKESEVSPSRRRKM-SPLRSLEHEETNMPTMHDLVHTINDQ--- 125
            +N +KD    L+  +A  E   SP+++ K+ S   S+  E  ++ T +  + T+  Q   
Sbjct: 1303 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1362

Query: 126  --SQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASG 183
              S+ +  +E E +  +++ +  + ++  V    E  +Q  ++  Q +   E+   +   
Sbjct: 1363 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1422

Query: 184  NMHNSWITTGEDSGVGETSKRPFSHD--------NADFGKAASAGEQLELEKLKLTYE-- 233
             M    +   E +   +  KR    +         A+    A   E  E  +L++  E  
Sbjct: 1423 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1482

Query: 234  ------------------------EKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEF 269
                                     + E  E+Q +  + +    +R  +D  ++ +  E 
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1542

Query: 270  LLAANT-------------CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLM 316
             LA+                  +  L L+  + E  L Q       Q    L   +    
Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602

Query: 317  SALVSVRSSLAD-TQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERL 375
            + L S R+S A+ T Q E S  E+   V Q+ EEA   + +   + ++ R+E ER+ ER 
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE-RRAQQQAEAERAREEAERELERW 1661

Query: 376  E-------------KELASQQEKRAIEKDMMKKEITKEREYMG--SKMLILSQNIAQLEA 420
            +             +E+A Q+     E +  K+E  +E    G   +  +  + +A+ E 
Sbjct: 1662 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1721

Query: 421  Q-----VEKVTKEKISAINQLEEIQSQLASREMD---VTKVCGEMRYQLNKTNMEKDEAE 472
            +      E   +++++A  +L  ++++    E     + +    ++ +      ++ E E
Sbjct: 1722 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1781

Query: 473  KEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESE 532
             E  + RA+    L  K +  E+ R   ++SKQ LE E  +     EE  RL  L  E++
Sbjct: 1782 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841

Query: 533  HQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQM-EAQHDKTENEQYLL-LT 590
             Q  L  ++               A Q  + E+ L +K+  + EA   KTE E  L    
Sbjct: 1842 RQRQLAEED--------------AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1887

Query: 591  SQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNE-ELEEQC 649
            ++N  L +L E+     ++LE+          Q +Q K    ++L +L++ ++ ELE   
Sbjct: 1888 AENERLRRLAEDEAFQRRRLEE----------QAAQHKADIEERLAQLRKASDSELER-- 1935

Query: 650  VQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSL-SEEVDRLRTQ 704
             Q G V +T++QR RQ+++   A      +  + + +L LE   + S   D LR++
Sbjct: 1936 -QKGLVEDTLRQR-RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1989



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 154/706 (21%), Positives = 294/706 (41%), Gaps = 88/706 (12%)

Query: 70   QSHAVNQLKDLLRQQADKESEVSPSRRRKMSP-----LRSLEHEETNMPTMHDLVHTIND 124
            Q+  V Q K L + +A+K+ E +    R+        +R  E  E  +     L      
Sbjct: 1674 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1733

Query: 125  Q----SQYIHHLEAEVK-------FCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETL 173
            Q     Q +  L AE +         +EEL+ ++ +      + + L+ +L   R E   
Sbjct: 1734 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-- 1791

Query: 174  REQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQL-----ELEKL 228
              + LL +            E     E SK+    +   F + A    +L     E ++ 
Sbjct: 1792 --EVLLASKARAEE------ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1843

Query: 229  KLTYEEKCEIEESQL-KFLRNDLA---EYQRTCEDLKEQLKHKEF------LLAANTCNR 278
            +   EE    + ++  + L   LA   E  R   + +  LK KE        LA +   +
Sbjct: 1844 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1903

Query: 279  VGGLCLKCAQHEAVLSQTHTNVHMQT----------IERLVKERDDLMSALVSVRSSLAD 328
               L  + AQH+A + +    +   +          +E  +++R  +   ++++++S   
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1963

Query: 329  TQQREASAYEQVKQVLQISEEANFEKTKALIQCD---QLRKELERQA----ERLEKELAS 381
                +A    ++ ++   +E+    K +A ++     QL  E ER+     ER++K LA+
Sbjct: 1964 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2023

Query: 382  QQE-----KRAIEK-DMMKKEITKER------EYMGSKMLILSQNIAQLEAQVEKVTKEK 429
            ++E     K A+E+ + +K ++ + R      E   ++ L L+Q  AQ   Q E+  K  
Sbjct: 2024 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE--KAH 2081

Query: 430  ISAINQLE-EIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEI 488
              A+ Q E E+Q  L   +  + ++ GE      +   E +EA  +     A++ R +E 
Sbjct: 2082 AFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQSRRQVE- 2139

Query: 489  KDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQS 548
               E E+L+   +E  Q   Q Q  A   R+E  +      ++E      +Q  D+  + 
Sbjct: 2140 ---EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2196

Query: 549  FSKEAKAQALQAQQREQELTQ-KIQQMEAQHDKT-ENEQYLLLTSQNTFL----TKLKEE 602
              K A+    Q  Q EQELT  ++Q  E  H K   +E+   L ++ T      ++++EE
Sbjct: 2197 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2256

Query: 603  CCTLAKKLEQISQ-KTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQ 661
              ++  ++E++S+ K R E    +   R   +    LQ   E++++   +  R+    ++
Sbjct: 2257 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2316

Query: 662  --RLRQLDKHSQATAQQLVQ-LLSKQNQLLLERQSLSEEVDRLRTQ 704
              RLRQL +   A  + L + +L ++ Q + E   L  E + L+ Q
Sbjct: 2317 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2362



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 90/404 (22%), Positives = 188/404 (46%), Gaps = 31/404 (7%)

Query: 327  ADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELA-SQQEK 385
            A+ ++R A     +++  Q++E     K +A  +  +L++ ++ +  R E+    +QQ+K
Sbjct: 1383 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1442

Query: 386  RAIEKDMMKKEITKEREYMGS---------KMLILSQNIAQLEAQVEKVTKEKISAINQL 436
            R+I++++ +   + E E               L + + I  +  Q+E   +++  A  +L
Sbjct: 1443 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1502

Query: 437  EEIQSQLASREMDVTKVCGE---MRYQLNKTNMEKDEAEKE---HREFRAKTNRDLEIKD 490
            + ++++    E    +   E   +R Q+   +  K +AE E     +  A+  R+ +   
Sbjct: 1503 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1562

Query: 491  QEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS 550
            Q +E+LR++ +E+++ L Q + + A   +  L   +   E+E Q       + + Q   S
Sbjct: 1563 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1622

Query: 551  KEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKL 610
             + +  A+ AQ RE+   +  QQ EA+  + E E+ L              E   L  + 
Sbjct: 1623 LQEEHVAV-AQLREEAERRAQQQAEAERAREEAERELERWQLKA------NEALRLRLQA 1675

Query: 611  EQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHS 670
            E+++Q+    +AQ   EK+   ++  +  RR  + EEQ V+   + E   ++ RQL + +
Sbjct: 1676 EEVAQQ--KSLAQAEAEKQK--EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1731

Query: 671  Q----ATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQ 710
                 A  Q+L++L ++  Q   +RQ L EE+ RL+ +  +  Q
Sbjct: 1732 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1775



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 133/652 (20%), Positives = 268/652 (41%), Gaps = 66/652 (10%)

Query: 68   LQQSH-AVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQS 126
            LQ+ H AV QL++   ++A +++E   +R       R LE  +        L     + +
Sbjct: 1623 LQEEHVAVAQLREEAERRAQQQAEAERAREEAE---RELERWQLKANEALRLRLQAEEVA 1679

Query: 127  QYIHHLEAEVKFCKEELSGMKNKI----QVVVLENEGLQQQLKSQRQEETLREQTLLDAS 182
            Q     +AE +  KEE      +     +  V + E  +Q+L+ QRQ      Q  L A 
Sbjct: 1680 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1739

Query: 183  GNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQ 242
              +    I    ++  GE  ++    + A   + A+A  Q   E      + + E+E   
Sbjct: 1740 QEL----IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1795

Query: 243  LKFLRNDLAEYQRTCEDLKEQLKHK--EFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNV 300
                R +  E + T E  K++L+ +   F   A    R+  L  + A+ +  L++     
Sbjct: 1796 ASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAAR 1853

Query: 301  HMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQ 360
                 ER++ E+   +     +++      + + +  E++++   ++E+  F++ +   Q
Sbjct: 1854 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQRRRLEEQ 1910

Query: 361  CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEA 420
              Q + ++E +  +L K   S+ E+   +K +++  + + R+        + + I  L+A
Sbjct: 1911 AAQHKADIEERLAQLRKASDSELER---QKGLVEDTLRQRRQ--------VEEEILALKA 1959

Query: 421  QVEKVTKEKISAINQLEEIQSQ----LASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHR 476
              EK    K     +L  I+S     L S+E    +   + +    +    ++  E+  +
Sbjct: 1960 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2019

Query: 477  EFRAKTN--RDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQ 534
               A+    R  +   +E+E+L+ +++E+++  E+ +Q                 ES  Q
Sbjct: 2020 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ-----------------ESARQ 2062

Query: 535  LHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNT 594
            L L ++   + Q+    E KA A   QQ+EQEL Q +QQ ++  D+   E      +   
Sbjct: 2063 LQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA--- 2116

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQH-G 653
               +  EE    A++    S++   E  +L Q          + Q   E+L ++  Q   
Sbjct: 2117 --AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2174

Query: 654  RVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
            R  +  +  LRQ     QA   ++ +      Q L ++  + +E+  LR QL
Sbjct: 2175 RRAQAEQAALRQ----KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2222



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 114/514 (22%), Positives = 224/514 (43%), Gaps = 73/514 (14%)

Query: 224  ELEKLKLTYEE---KCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVG 280
            ELE  K + ++   + E ++     LR++L   Q   E L+++   ++ +       RV 
Sbjct: 1151 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD-VEVERWRERVA 1209

Query: 281  GLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQV 340
             L     + +AVL+QT  +V  + +E+L ++      +   + + L D ++R+    EQ+
Sbjct: 1210 QLL---ERWQAVLAQT--DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ----EQI 1260

Query: 341  KQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIEKDMMKKEITK 399
            + +     +A  E+ +   Q   L +E+ER  E++E+ +  ++Q   AI KD   + +T 
Sbjct: 1261 QAMPLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINAI-KDYELQLVTY 1316

Query: 400  EREYMGSKMLILSQNIAQLEAQVEKVTKEKI-----SAINQLEEIQ---SQLASREMDVT 451
            +               AQLE       K K+     S I +  +++   S+L +      
Sbjct: 1317 K---------------AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1361

Query: 452  KVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIE-----KLRIELDESKQH 506
            K   E   ++ +     ++   E RE  A+    LE + Q  E     K + E  E+K+ 
Sbjct: 1362 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKEL 1420

Query: 507  LEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQ- 565
             ++ Q       EE +R  E   +++ Q    ++E   ++QS   E +A+A QA+  E+ 
Sbjct: 1421 QQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1473

Query: 566  --ELTQKIQQMEAQHDKTENE--------QYLLLTSQNTFLTK--LKEECCTLAKKLEQI 613
               + ++I+ +  Q + TE +        Q L   ++     K   +EE   L ++++  
Sbjct: 1474 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533

Query: 614  SQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQAT 673
            SQ+ R    +L+   +   +   + QR  + LEE  +Q     E  ++RLRQ +      
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ----AEEAERRLRQAEVERARQ 1589

Query: 674  AQQLVQLL--SKQNQLLLERQSLSEEVDRLRTQL 705
             Q  ++    S + +L  +R S +E+  +L   L
Sbjct: 1590 VQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 88/443 (19%), Positives = 193/443 (43%), Gaps = 52/443 (11%)

Query: 222  QLELEKLKLTYEEKCEI-----EESQLKFL-RNDLAEYQRTCEDLKEQLKHKEFLLAANT 275
            Q E EK+K   EE   +     E ++L+ L   DLA+ +   E +      KE + A   
Sbjct: 2294 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-----KEKMQAVQE 2348

Query: 276  CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSV-----RSSLADTQ 330
              R+        + EA L Q    +  +   RL ++++ +   L        R+  A+ Q
Sbjct: 2349 ATRL--------KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400

Query: 331  QREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEK-ELASQQEKRAIE 389
            ++   + E  +  L+++E +  +  +A     + RK+ E   E+L + ELA+Q++   ++
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQ-ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2459

Query: 390  K-DMMKKEITKEREYMGSKMLILSQNIAQL--EAQVEKVTKEKISAINQLEEIQSQLASR 446
              ++ +++   + E +   +  L +   +L  EA++ ++  E++  + Q + +Q   A +
Sbjct: 2460 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2519

Query: 447  EMDVTK----VCGEMRYQLNKTNMEK---DEAEKEHREFRAKTNRDLEIKDQEIEKLRIE 499
            +  +++    +  E   +  K  +E+   DE  K  ++ R +  R  +  +QE ++L   
Sbjct: 2520 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-QQLREEQQRQQQQMEQERQRLVAS 2578

Query: 500  LDESKQHLEQEQQKAALAREECLRL-------TELLGESEHQLHLTRQ---EKDSIQQSF 549
            ++E+++   + ++     +EE  +L        ELL E   +L    Q   E+     + 
Sbjct: 2579 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2638

Query: 550  SKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKK 609
            S+E  A  + A    + L      ++    + E E       +     +L+E     A++
Sbjct: 2639 SEEVTASQVAA---TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2695

Query: 610  LEQISQ--KTRSEIAQLSQEKRY 630
            L++++Q   T  E+A+    + Y
Sbjct: 2696 LQRLAQGHTTVDELARREDVRHY 2718



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 80/412 (19%), Positives = 171/412 (41%), Gaps = 43/412 (10%)

Query: 326  LADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEK 385
            +A+ Q+ +A      K V ++S EA  EK  AL +       L  + E    +L   +  
Sbjct: 1050 IAEQQKAQAEVEGLGKGVARLSAEA--EKVLALPEPSPAAPTLRSELELTLGKLEQVRSL 1107

Query: 386  RAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAIN-QLEEIQSQLA 444
             AI  + +K      R   G++ ++ +      EAQ    T  ++ A    L+++++Q  
Sbjct: 1108 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1167

Query: 445  SREMDVTKVCGEMR------YQLNKTNMEKDEAEKEHREFRAKTNR-------DLEIKDQ 491
            +++     +  E+R       +L + + E+D   +  RE  A+            +++ +
Sbjct: 1168 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR 1227

Query: 492  EIEKLRIELD---ESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEK---DSI 545
            E+E+L  +L    ES   L    Q A   +E+   +   L +S+      RQE+   + I
Sbjct: 1228 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEI 1285

Query: 546  QQSFSKEAKAQALQAQ------QREQELTQKIQQME-----AQHDKTENEQYLLLTSQNT 594
            ++   K  + Q    Q        E +L     Q+E     A+  K ++    ++     
Sbjct: 1286 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD 1345

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGR 654
              T   E     ++ ++ IS+  R    ++ +E+R    +  + + R  E+E    +  +
Sbjct: 1346 LRTHYSELTTLTSQYIKFISETLR----RMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1401

Query: 655  VHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQ----SLSEEVDRLR 702
            + E   Q   Q ++ ++   Q++ + + ++ +  ++ Q    S+ EE+ +LR
Sbjct: 1402 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1453


>gi|32698688 citron [Homo sapiens]
          Length = 2027

 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 150/663 (22%), Positives = 286/663 (43%), Gaps = 85/663 (12%)

Query: 76   QLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHD----LVHTINDQSQYIHH 131
            +LK    Q++  E +++       S  RSLE     +    D    L+H I +QS+ +  
Sbjct: 492  ELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQE 551

Query: 132  L-EAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLL------DASGN 184
            + E E +   EE+  M N+     LE + +  + +S   E  LRE  L        A+  
Sbjct: 552  IKEQEYQAQVEEMRLMMNQ-----LEEDLVSARRRSDLYESELRESRLAAEEFKRKATEC 606

Query: 185  MHNSWITTGEDSG---VGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEES 241
             H   +   +D G   VGE +K           +  +A +QL++++L+   E+  +    
Sbjct: 607  QHK--LLKAKDQGKPEVGEYAKL----------EKINAEQQLKIQELQEKLEKAVKASTE 654

Query: 242  QLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVH 301
              + L+N     +R   +L E+L+++E          V    L+    EA +S  H  VH
Sbjct: 655  ATELLQNIRQAKERAEREL-EKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVH 713

Query: 302  MQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQC 361
            ++  E+  +E+  ++     ++  LAD         E ++ ++Q  EE   EK K L + 
Sbjct: 714  LKQKEQHYEEKIKVLDN--QIKKDLADK--------ETLENMMQRHEEEAHEKGKILSEQ 763

Query: 362  DQLRKELERQAERLEKELASQQEKRAIE-------------KDMMKKEITKEREYMGSKM 408
              +   ++ +   LE+ +    E   +              ++ M  E+ +++ Y+ ++ 
Sbjct: 764  KAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQA 823

Query: 409  LILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEK 468
              L     +LE Q+EK++ +  S  N+L E++++L    ++  +   E++ QL +  +  
Sbjct: 824  GKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSL 883

Query: 469  DEAEKE---HREFRAKTNRDLEIKDQEIEKLRIELDESKQ----HLEQEQQKAALAREEC 521
             E E +    +  RA     L     E+E+   E +E  Q    H ++ Q+K    R  C
Sbjct: 884  QERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC 943

Query: 522  LRLTELLGESEHQLH-LTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDK 580
              +T+L    E QL+ LT    +   Q+F      Q  +A     E+ Q   + E  H +
Sbjct: 944  TVITDL----EEQLNQLTEDNAELNNQNF--YLSKQLDEASGANDEIVQ--LRSEVDHLR 995

Query: 581  TE-NEQYLLLTSQNTFLTKLKEECCTLAKK---LEQISQKTRSEIAQLSQEKRYTYDKLG 636
             E  E+ + LTSQ   +  LK  C  L ++   LE ++ +   +  Q    +    D+  
Sbjct: 996  REITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKS 1055

Query: 637  KLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQN--QLLLERQSL 694
            + + R  EL+       R+ +T KQ   + D+     ++Q+V+L  K++  ++L  +Q+L
Sbjct: 1056 QFECRVRELQ-------RMLDTEKQSRARADQRI-TESRQVVELAVKEHKAEILALQQAL 1107

Query: 695  SEE 697
             E+
Sbjct: 1108 KEQ 1110



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 109/495 (22%), Positives = 197/495 (39%), Gaps = 79/495 (15%)

Query: 218 SAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCN 277
           S  +   +EK  L   ++ +  + +   +  ++    R   +++  L  KE  L A+   
Sbjct: 440 SPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQ 499

Query: 278 R------VGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQ 331
           R      +     +C+  +  L Q    V         +E D  +  L  +R      Q+
Sbjct: 500 RSLLEQDLATYITECSSLKRSLEQARMEVS--------QEDDKALQLLHDIREQSRKLQE 551

Query: 332 REASAYE-QVKQVLQISEEANFEKTKALIQCDQLRKELERQ---AERLEKELASQQEKRA 387
            +   Y+ QV+++  +  +   +   A  + D    EL      AE  +++    Q K  
Sbjct: 552 IKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLL 611

Query: 388 IEKDMMKKEITKEREYMGSKMLILSQN--IAQLEAQVEKVTKEKISAINQLEEIQS--QL 443
             KD  K E+    EY   + +   Q   I +L+ ++EK  K    A   L+ I+   + 
Sbjct: 612 KAKDQGKPEVG---EYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKER 668

Query: 444 ASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDES 503
           A RE++  +   +    + K  +E +E E++HRE +              + L + L + 
Sbjct: 669 AERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSA-----------QHLEVHLKQK 717

Query: 504 KQHLEQE------QQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQA 557
           +QH E++      Q K  LA +E L    ++   E + H    EK  I      E KA  
Sbjct: 718 EQHYEEKIKVLDNQIKKDLADKETLE--NMMQRHEEEAH----EKGKILS----EQKAMI 767

Query: 558 LQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKT 617
                + + L Q+I ++   +    N    L T +N    K +EE               
Sbjct: 768 NAMDSKIRSLEQRIVELSEANKLAANSS--LFTQRNM---KAQEEM-------------- 808

Query: 618 RSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQL 677
              I++L Q+K Y   + GKL+ +N +LEEQ  +      + K RL +L+     T  + 
Sbjct: 809 ---ISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELE-----TRLRE 860

Query: 678 VQLLSKQNQLLLERQ 692
           V L  ++ +L L+RQ
Sbjct: 861 VSLEHEEQKLELKRQ 875



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 136/668 (20%), Positives = 265/668 (39%), Gaps = 85/668 (12%)

Query: 61   ARTAWPELQQSHAVNQLKDLLRQQADK---ESEVSPSRRRKMSPLRSLE--HEETNMPTM 115
            A T   EL Q+  + Q K+   ++ +K     + S   R+K+     LE  H E  +   
Sbjct: 651  ASTEATELLQN--IRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQ 708

Query: 116  HDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLRE 175
            H  VH    +  Y           +E++  + N+I+  + + E L+  +  QR EE   E
Sbjct: 709  HLEVHLKQKEQHY-----------EEKIKVLDNQIKKDLADKETLENMM--QRHEEEAHE 755

Query: 176  Q-TLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEE 234
            +  +L     M N+      DS +    +R      A+  K A+         +K   E 
Sbjct: 756  KGKILSEQKAMINAM-----DSKIRSLEQRIVELSEAN--KLAANSSLFTQRNMKAQEEM 808

Query: 235  KCEIEESQ--LKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAV 292
              E+ + +  L+     L    R  E+  E++ H++     +  NR+  L       E  
Sbjct: 809  ISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDH----SDKNRLLEL-------ETR 857

Query: 293  LSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANF 352
            L +       Q +E L ++  +L  +L    S L   Q   A+   Q++Q     EE   
Sbjct: 858  LREVSLEHEEQKLE-LKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTA 916

Query: 353  EKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILS 412
            E  + +      R E++R+ + L        +   +E+ +   ++T++   + ++   LS
Sbjct: 917  EAEEEIQALTAHRDEIQRKFDALRNSCTVITD---LEEQL--NQLTEDNAELNNQNFYLS 971

Query: 413  QNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTK----------VCGEMRYQLN 462
            + + +     +++ + +    ++++ ++ ++  REM +T            C  +  Q+ 
Sbjct: 972  KQLDEASGANDEIVQLR----SEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVM 1027

Query: 463  KTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECL 522
                  DE  ++ R++ A  +    +   E  +    + E ++ L+ E+Q  A A +   
Sbjct: 1028 DLEALNDELLEKERQWEAWRS----VLGDEKSQFECRVRELQRMLDTEKQSRARADQ--- 1080

Query: 523  RLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTE 582
            R+TE    S   + L  +E  +   +  +  K Q L+A+     L+ K+  +E +H   E
Sbjct: 1081 RITE----SRQVVELAVKEHKAEILALQQALKEQKLKAES----LSDKLNDLEKKHAMLE 1132

Query: 583  NEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRN 642
                 L     T   +LK+       KL+Q     ++ I +L+Q  +   D+   L+   
Sbjct: 1133 MNARSLQQKLETE-RELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTER 1191

Query: 643  EELEEQC--VQHGRVHETMKQR--LRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEV 698
             +LE Q   +Q    HE +K    + Q  K       ++ Q   K+  L   R    +E 
Sbjct: 1192 SDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRR----KED 1247

Query: 699  DRLRTQLP 706
              L TQ+P
Sbjct: 1248 PALPTQVP 1255


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 137/639 (21%), Positives = 272/639 (42%), Gaps = 69/639 (10%)

Query: 75   NQLKDLLRQ-QADKESEVSPSR----RRKMSPLRSLEHEET-NMPTMHDLVHTINDQS-- 126
            +Q  DL  Q + +KE+ V  ++     R+    R LE  +  +  +  DL H + +Q   
Sbjct: 1218 DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER 1277

Query: 127  ----------QYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQ 176
                      Q   H   E +  +EE    K + +    +++  +Q L+ +R+E+  R++
Sbjct: 1278 DREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR----KSQEEKQLLREEREEKRRRQE 1333

Query: 177  TLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKC 236
            T                E+  + E  ++P      D           E  +  L  E++ 
Sbjct: 1334 T----------DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL 1383

Query: 237  EIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQT 296
              +E + KFL+    E Q  C++ ++QL+                   K  + E  LS+ 
Sbjct: 1384 RRQERERKFLKE---EQQLRCQEREQQLRQDRDR--------------KFREEEQQLSRQ 1426

Query: 297  HTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTK 356
              +   +  E+ V+ R +     +     L   + R+    EQ+ Q  +  +    E+ +
Sbjct: 1427 ERDRKFREEEQQVR-RQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485

Query: 357  ALIQCDQLRKELERQAERLEKELASQQ-EKRAIEKDMMKKEITKEREYMGSKMLILSQNI 415
              ++ +Q  +  ER  +  E+EL SQ+ E++ +E++       ++R+++  +  +  Q  
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQER 1545

Query: 416  AQLEAQV-EKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKE 474
             Q   Q  ++  +E+     + EE Q     R+        ++R Q  +    +DE +  
Sbjct: 1546 GQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR 1605

Query: 475  HREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQ 534
             +E + +  ++ + K +E E+L  E +E + H  QE+ +  L  E  LR  E     E Q
Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQEREEQQLH-RQERDRKFLEEEPQLRRQE----REQQ 1660

Query: 535  LHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNT 594
            L   R  K   ++   +E + Q L+ Q+R+++  ++ QQ+  Q    E E+  L   Q  
Sbjct: 1661 LRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ----ERERKFLQEEQQL 1716

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGR 654
               +L+ +     ++ EQ+ Q+T  E  QL +++RY    L + Q R E  E+Q  +  R
Sbjct: 1717 RRQELERK----FREEEQLRQETEQE--QLRRQERYR-KILEEEQLRPEREEQQLRRQER 1769

Query: 655  VHE-TMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQ 692
              +   +++LRQ  +  Q  +Q+  +   ++ QL  ER+
Sbjct: 1770 DRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQERE 1808



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 97/405 (23%), Positives = 187/405 (46%), Gaps = 37/405 (9%)

Query: 330 QQREASAYEQVKQVLQISEEANFE-----KTKALIQCDQLRKELERQAERLEKELASQQE 384
           ++ E  A E+  Q  +  E   F      + + L++  +  +E ++Q  R  ++   Q+E
Sbjct: 182 EREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE 241

Query: 385 KRAIEKDMMKKE--ITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQ 442
           +   EK+  K+E  + KE E +  +     + + + E Q+ K+ ++++    Q EE Q Q
Sbjct: 242 E---EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298

Query: 443 LASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDE 502
              RE  + +   E R +  +   E+ E  +E +E R +     E +++  ++LR E +E
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQE-RREQQEERREQQLRREQEERREQQLRREQEE 357

Query: 503 S------KQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQ 556
                  ++  E+E+++  L RE+ LR  + L     +  L R+++   +Q   +E + +
Sbjct: 358 ERREQQLRREQEEERREQQLRREQQLRREQQL---RREQQLRREQQLRREQQLRREQQLR 414

Query: 557 ALQAQQREQEL--TQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQIS 614
             Q  +REQ+L   Q+ ++ E +H++   EQ  L   Q      LK E  T   + E+  
Sbjct: 415 REQQLRREQQLRREQEEERHEQKHEQERREQ-RLKREQEERRDWLKREEETERHEQERRK 473

Query: 615 Q--------KTRSEIAQLSQEKRYTYD--KLGKLQRRNEELEEQCVQHGRVHETMKQRLR 664
           Q        + R    +L +E+R      +  +L+R  EE  EQ ++     E ++QRLR
Sbjct: 474 QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533

Query: 665 QLDKHSQATAQQLVQLLSKQNQLLLER----QSLSEEVDRLRTQL 705
              +  +   ++  QLL ++ +  LE+    Q L  E +  R QL
Sbjct: 534 SEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 157/730 (21%), Positives = 294/730 (40%), Gaps = 91/730 (12%)

Query: 5   PENSTLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDA--- 61
           P +  LEE  GQ +R  R+   R        L EG+    +            +E+    
Sbjct: 124 PRDRQLEEEPGQRRRQKRQEQERE-------LAEGEEQSEKQERLEQRDRQRRDEELWRQ 176

Query: 62  RTAWPELQQSHAVN-QLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMH--DL 118
           R  W E ++  A   QL+     + ++  +    RRR++  LR    EE         D 
Sbjct: 177 RQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDR 236

Query: 119 VHTINDQSQYIHH---LEAEVKFCKEELSGMKNKIQVVVLENEGLQ-QQLKSQRQEETLR 174
           V    ++ ++      L  E +  +EE    + ++Q    +   L+ Q+L+ +RQEE  +
Sbjct: 237 VFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQ 296

Query: 175 EQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEE 234
           +Q L                     E  +R    +  +  +     E+   ++L+   EE
Sbjct: 297 QQRLRREQQLRRKQ-----------EEERREQQEERREQQERREQQEERREQQLRREQEE 345

Query: 235 KCEI-------EESQLKFLRNDLAEYQRTCEDLKEQ-LKHKEFLLAANTCNRVGGLCLKC 286
           + E        EE + + LR +  E +R  +  +EQ L+ ++ L       R   L  + 
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL--RR 403

Query: 287 AQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQI 346
            Q      Q      ++  ++L +E+++                +R    +EQ ++  ++
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEE----------------ERHEQKHEQERREQRL 447

Query: 347 SEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGS 406
             E    +       D L++E E   ER E+E   QQ KR  E++  ++ +  E E    
Sbjct: 448 KREQEERR-------DWLKREEE--TERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498

Query: 407 KMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNM 466
           +     Q   QL  + E+  ++++    + E +Q +L S E  + +   E R QL K   
Sbjct: 499 QQERREQ---QLRREQEERREQRLKRQEEEERLQQRLRS-EQQLRREQEERREQLLKREE 554

Query: 467 EKDEAEKEHREFRAKTN----RDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAR---- 518
           EK   E+E RE R K      RD  +K +E  + +    E ++ LEQ  ++  + R    
Sbjct: 555 EK-RLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613

Query: 519 ---EECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQME 575
              E+ L+  E   E   QL  + ++++  QQ   +E + +  Q  +RE+E  +  Q+++
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLK 673

Query: 576 AQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEI-----AQLSQEKRY 630
            +H++   EQ L    Q     ++K        +LE  +   +S++      Q  Q +R 
Sbjct: 674 REHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ 733

Query: 631 TYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLE 690
             ++    +RR  E E Q  +  R H   ++  ++ D   Q  A++  +   +  Q L  
Sbjct: 734 EQEE----KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE---RGRQRLSA 786

Query: 691 RQSLSEEVDR 700
           R  L E+ +R
Sbjct: 787 RPPLREQRER 796



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 88/396 (22%), Positives = 190/396 (47%), Gaps = 33/396 (8%)

Query: 328 DTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKEL---ERQAERLEKELASQQE 384
           + Q+R     E+ +Q L+  +E   E+     Q ++ R++    E++ ER E++L  +Q+
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382

Query: 385 KRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLA 444
            R  ++   ++++ +E++    + L   Q + + E Q+ +  + +     +  E + +  
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRR-EQQLRREQQLRREQEEERHEQKHEQE 441

Query: 445 SREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLR--IELDE 502
            RE  + +   E R  L K   E +  E+E R+ + K       +DQE E+    ++L+E
Sbjct: 442 RREQRLKREQEERRDWL-KREEETERHEQERRKQQLK-------RDQEEERRERWLKLEE 493

Query: 503 SKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQ 562
            ++  +QE+++  L RE+  R  + L   E +  L ++ +   Q    +E + + L  ++
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553

Query: 563 REQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIA 622
            E+ L Q+ ++   + ++ E    LL   +     +LK E     ++LEQ  +  R E+ 
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKRE---QEERLEQ--RLKREEVE 608

Query: 623 QLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLR--QLDKHSQ-----ATAQ 675
           +L QE+R   ++  K +   EE  +Q ++     E  +Q+LR  Q ++  Q        +
Sbjct: 609 RLEQEER--REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666

Query: 676 QLVQLLSKQNQLLLERQSLSEEV-----DRLRTQLP 706
           +L Q L ++++     Q L+EE      +R+++++P
Sbjct: 667 RLEQRLKREHEEERREQELAEEEQEQARERIKSRIP 702



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 121/561 (21%), Positives = 240/561 (42%), Gaps = 61/561 (10%)

Query: 156  ENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGK 215
            E E  QQ LKS+ QEE  ++Q   +             E+  + +  KR    +  +   
Sbjct: 626  EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQEL 685

Query: 216  AASAGEQLE------LEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEF 269
            A    EQ        + K +   E + +  +S++ + R    E QR  ++ +E+ + +E 
Sbjct: 686  AEEEQEQARERIKSRIPKWQWQLESEADARQSKV-YSRPRKQEGQRRRQEQEEKRRRRES 744

Query: 270  LLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADT 329
             L      R         Q +    +       Q  E+  + R  L     S R  L + 
Sbjct: 745  ELQWQEEERAH------RQQQEEEQRRDFTWQWQAEEKSERGRQRL-----SARPPLREQ 793

Query: 330  QQREASAYE-QVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAI 388
            ++R+  A E Q ++   + EE   E+ +      + R+E E++ + LE+E   Q+ +RA 
Sbjct: 794  RERQLRAEERQQREQRFLPEEEEKEQRR------RQRREREKELQFLEEEEQLQRRERAQ 847

Query: 389  EKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREM 448
            +    +  + +++E   S+     Q   +   Q+E+  K +   +     +Q QL   + 
Sbjct: 848  QLQEEEDGLQEDQERRRSQEQRRDQ---KWRWQLEEERKRRRHTLYAKPALQEQLRKEQQ 904

Query: 449  DVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLE 508
             +         Q  +  ++++E EK  R+ + +  R+ E   QE E+L  E  E ++  E
Sbjct: 905  LL---------QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955

Query: 509  QEQQ----KAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQRE 564
            +E+Q    K    +EE     +LLGE   +     +EK   ++   ++ + Q L+ ++RE
Sbjct: 956  RERQYRKDKKLQQKEE-----QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR-EERE 1009

Query: 565  QELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQL 624
            +   Q+ ++   + D+ + E+  LL  +     +L+E      ++  +  ++ + E  QL
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLREERE-KRRLQER-----ERQYREEEELQQEEEQL 1063

Query: 625  SQEKRYT--YDKLGKLQRRNEELEEQCVQ------HGRVHETMKQRLRQLDKHSQATAQQ 676
              E+R T    +L +  R+ EEL+++  Q        R  +  +++ R+ ++  Q   Q 
Sbjct: 1064 LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL 1123

Query: 677  LVQLLSKQNQLLLERQSLSEE 697
            L +   K+ +  LERQ   EE
Sbjct: 1124 LREEREKRRRQELERQYREEE 1144



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 128/672 (19%), Positives = 278/672 (41%), Gaps = 96/672 (14%)

Query: 64   AWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTIN 123
            A P LQ+   + + + LL+++ ++       +RR+    R    EE        L   + 
Sbjct: 891  AKPALQEQ--LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQL---LR 945

Query: 124  DQSQYIHHLEAEVKFCKEE-LSGMKNKIQVVVLENEGLQQQLKSQRQEETLR--EQTLL- 179
            ++ +     E E ++ K++ L   + ++     E    Q++ K  R+EE L+  E+ LL 
Sbjct: 946  EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR 1005

Query: 180  -DASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEI 238
             +        W          +  +     +           E+  L++ +  Y E+ E+
Sbjct: 1006 EEREKRRRQEWERQYRKKDELQQEEEQLLREER---------EKRRLQERERQYREEEEL 1056

Query: 239  EESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHT 298
            ++ + + L  +    +R  ++L+ Q + +E L                 + E +L +   
Sbjct: 1057 QQEEEQLLGEERETRRR--QELERQYRKEEELQQ---------------EEEQLLREEPE 1099

Query: 299  NVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKAL 358
                Q  ER  +E ++L      +       ++RE    +++++  +  EE   E+ + L
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLR-----EEREKRRRQELERQYREEEEVQQEEEQLL 1154

Query: 359  IQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIA-- 416
             +  + R+  E + +  E+E   Q+E++ + ++  K+   +ER+Y   + L   +     
Sbjct: 1155 REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214

Query: 417  -----------QLEAQVEKVTKE--------KISAINQLEEIQSQLASREMDVTKVCGEM 457
                       Q E + E   ++        +     QLE+ Q +    + D+  + GE 
Sbjct: 1215 RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274

Query: 458  RYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALA 517
            +    + + E++    + R+        LE ++Q+  K R    + ++ L +E+++    
Sbjct: 1275 Q----ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRR 1330

Query: 518  REECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQ 577
            R+E    T+     E QL   R+E+   +Q   ++ + + L+ Q++ ++  ++ Q++  Q
Sbjct: 1331 RQE----TDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQ 1386

Query: 578  HDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQ-ISQKTRSEIAQLSQEKRYTYDKLG 636
                E E+  L   Q          C    ++L Q   +K R E  QLS+++R    +  
Sbjct: 1387 ----ERERKFLKEEQQL-------RCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREE 1435

Query: 637  KLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQ---- 692
            + Q R +E E + ++        +Q+LRQ ++H +   ++  QLL ++ +  L RQ    
Sbjct: 1436 EQQVRRQERERKFLEE-------EQQLRQ-ERHRKFREEE--QLLQEREEQQLHRQERDR 1485

Query: 693  SLSEEVDRLRTQ 704
               EE  +LR Q
Sbjct: 1486 KFLEEEQQLRRQ 1497



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 141/669 (21%), Positives = 270/669 (40%), Gaps = 103/669 (15%)

Query: 60   DARTAWPELQQSHAVNQLKDLLRQ-----QADKESEVSPSRRRKMSPLRS-----LEHEE 109
            ++   W E +++H   Q ++  R      QA+++SE    R     PLR      L  EE
Sbjct: 743  ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE 802

Query: 110  TNMPTMHDLVHTINDQSQ--YIHHLEAEVKFCKEELS-GMKNKIQVVVLENEGLQQQLKS 166
                    L      + +       E E++F +EE     + + Q +  E +GLQ+  + 
Sbjct: 803  RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862

Query: 167  QRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELE 226
            +R +E  R+Q            W    E     E  KR     +  + K A   EQL  E
Sbjct: 863  RRSQEQRRDQ-----------KWRWQLE-----EERKR---RRHTLYAKPA-LQEQLRKE 902

Query: 227  KLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKC 286
            + +L  EE+ E++  + +  R    E Q   E   EQL+ +E                  
Sbjct: 903  Q-QLLQEEEEELQREEREKRRRQEQERQYREE---EQLQQEE------------------ 940

Query: 287  AQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQI 346
               E +L +       Q  ER  ++   L      +     + ++R+    E+ K+  + 
Sbjct: 941  ---EQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ----EREKKYRE- 992

Query: 347  SEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGS 406
             EE   E+ + L +  + R+  E + +  +K+   Q+E++ + ++  K+ + +ERE    
Sbjct: 993  EEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRL-QERERQYR 1051

Query: 407  KMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNM 466
            +   L Q   QL  + E+ T+ +       +E++ Q    E            Q  +  +
Sbjct: 1052 EEEELQQEEEQLLGE-ERETRRR-------QELERQYRKEE----------ELQQEEEQL 1093

Query: 467  EKDEAEKEHREFRAKTNRDLEIKDQEIEKL---------RIELD---ESKQHLEQEQQKA 514
             ++E EK  R+ R +  R+ E   QE E+L         R EL+     ++ ++QE+++ 
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153

Query: 515  ALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQM 574
                 E  R  EL  +   +  L ++E+  +++   K  + +  Q ++ E+   QK +Q 
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213

Query: 575  EAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDK 634
                D+  + ++     +   +   K  C    ++ EQ  Q   S++    Q ++     
Sbjct: 1214 YRDEDQRSDLKWQWEPEKENAVRDNKVYC--KGRENEQFRQLEDSQLRD-RQSQQDLQHL 1270

Query: 635  LGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQS- 693
            LG+ Q R+ E E +  Q    H   ++   QL++  Q  A++  +   ++ QLL E +  
Sbjct: 1271 LGEQQERDREQERRRWQQRDRHFPEEE---QLEREEQKEAKRRDRKSQEEKQLLREEREE 1327

Query: 694  --LSEEVDR 700
                +E DR
Sbjct: 1328 KRRRQETDR 1336



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 88/395 (22%), Positives = 185/395 (46%), Gaps = 39/395 (9%)

Query: 326  LADTQQREASAYEQVKQVLQISEEANFEKTKALIQC--------DQLRKELERQAERLEK 377
            L D+Q R+  + + ++ +L   +E + E+ +   Q         +QL +E +++A+R ++
Sbjct: 1253 LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR 1312

Query: 378  ELASQQEKRAIEKDMMKKEITKE--REYMGSKMLILSQNIAQLEAQVE--KVTKEKISAI 433
            +  SQ+EK+ + ++  +K   +E  R++   + L+  +    L  Q    K  +E++   
Sbjct: 1313 K--SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370

Query: 434  NQ----LEEIQS-QLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEI 488
             Q    LEE Q  +   RE    K   ++R Q  +  + +D   K   E +  + ++ + 
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430

Query: 489  KDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQS 548
            K +E E+     +  ++ LE+EQQ       +     +LL E E Q  L RQE+D   + 
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ-QLHRQERD---RK 1486

Query: 549  FSKEAKAQALQAQQREQEL-TQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLA 607
            F +E   Q L+ Q+R+++   Q+++  E +    E EQ   L  Q      L+EE     
Sbjct: 1487 FLEE--EQQLRRQERDRKFREQELRSQEPERKFLEEEQQ--LHRQQRQRKFLQEE----- 1537

Query: 608  KKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLD 667
               +Q+ ++ R +  +  +++++  ++  + +R  ++L  Q  +  R     +Q++R+ +
Sbjct: 1538 ---QQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ--ERDRKFRLEEQKVRRQE 1592

Query: 668  KHSQ-ATAQQLVQLLSKQNQLLLERQSLSEEVDRL 701
            +  +    +Q ++    Q QL  ER     E ++L
Sbjct: 1593 QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 122/644 (18%), Positives = 264/644 (40%), Gaps = 93/644 (14%)

Query: 81   LRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVKFCK 140
            L+Q+ ++     P +RR+    +    EE        L   + ++ +     E E ++ K
Sbjct: 966  LQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL---LREEREKRRRQEWERQYRK 1022

Query: 141  -EELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVG 199
             +EL   + ++     E   LQ++ +  R+EE L+++                 E+  +G
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQE-----------------EEQLLG 1065

Query: 200  ETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCED 259
            E                    E    ++L+  Y ++ E+++ + + LR +  + +R  ++
Sbjct: 1066 EER------------------ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRR--QE 1105

Query: 260  LKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSAL 319
             + Q + +E L                 + E +L +       Q +ER  +E +++    
Sbjct: 1106 RERQCREEEELQ---------------QEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150

Query: 320  VSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKEL 379
              +     + ++R     +++++  +  EE   E+ + L +  + R++   +  R E+EL
Sbjct: 1151 EQLLREEPEKRRR-----QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEEL 1205

Query: 380  ASQQEKRAIEKDMMKKEI------TKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAI 433
              Q+ K+    +  + ++       KE     +K+    +   Q     +   +++ S  
Sbjct: 1206 QRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQ- 1264

Query: 434  NQLEEI--QSQLASREMDVTKVCGEMRYQLNKTNMEKDE-AEKEHREFRAKTNRDLEIKD 490
              L+ +  + Q   RE +  +     R+   +  +E++E  E + R+ +++  + L  ++
Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324

Query: 491  QEIEKLRIELD---ESKQHLEQEQQKAALAREE---CLRLTELLGES------EHQLHLT 538
            +E ++ R E D     ++ L QE+++  L R+E     R  EL  +       E +  L 
Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLR 1384

Query: 539  RQEKDSIQQSFSKEAKAQALQAQQREQELTQ----KIQQMEAQHDKTENEQYLLLTSQNT 594
            RQE+   ++ F KE   Q L+ Q+REQ+L Q    K ++ E Q  + E ++      Q  
Sbjct: 1385 RQER---ERKFLKE--EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQV 1439

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGR 654
               + + +     ++L Q   +   E  QL QE+        +  R+  E E+Q  +  R
Sbjct: 1440 RRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQER 1499

Query: 655  VHETMKQRLR-QLDKHSQATAQQLVQLLSKQNQLLLERQSLSEE 697
              +  +Q LR Q  +      +Q +    +Q + L E Q L  +
Sbjct: 1500 DRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQ 1543



 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 137/670 (20%), Positives = 279/670 (41%), Gaps = 55/670 (8%)

Query: 67  ELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSL--EHEETNMPTMHDLVHTIND 124
           ELQ+     QL+ L RQ+  +E +    +++++   + L  + EE       +       
Sbjct: 270 ELQEEE--EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER 327

Query: 125 QSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLK----SQRQEETLREQTLLD 180
           + Q     E +++  +EE    + + +    E E  +QQL+     +R+E+ LR +  L 
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQ---EEERREQQLRREQEEERREQQLRREQQLR 384

Query: 181 ASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIE- 239
               +        E     E   R       +  +     +QL  E+ +  +E+K E E 
Sbjct: 385 REQQLRREQQLRREQQLRREQQLRREQQLRRE--QQLRREQQLRREQEEERHEQKHEQER 442

Query: 240 -ESQLKFLRNDLAEYQRTCEDLK--EQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQT 296
            E +LK  + +  ++ +  E+ +  EQ + K+ L       R     LK  + E    Q 
Sbjct: 443 REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER-RERWLKLEEEERREQQE 501

Query: 297 HTNVHMQTIERLVKE-RDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFE-- 353
                ++  +   +E R         ++  L   QQ      E+ +Q+L+  EE   E  
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561

Query: 354 ------KTKALIQCDQL-RKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGS 406
                 K +   + DQL ++E ER+ +RL++E   + E+R   +++ + E  + RE    
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK 621

Query: 407 KMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNM 466
           +     +   QL    E+  + +     + +E + Q   RE +  ++   ++ +  +   
Sbjct: 622 REEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERR 681

Query: 467 EKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREEC----- 521
           E++ AE+E  + R +    +     ++E    +  +SK +    +Q+    R+E      
Sbjct: 682 EQELAEEEQEQARERIKSRIPKWQWQLES-EADARQSKVYSRPRKQEGQRRRQEQEEKRR 740

Query: 522 LRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELT-------QKIQQM 574
            R +EL  + E + H  +QE++  ++ F+ + +A+  ++++  Q L+       Q+ +Q+
Sbjct: 741 RRESELQWQEEERAHRQQQEEEQ-RRDFTWQWQAEE-KSERGRQRLSARPPLREQRERQL 798

Query: 575 EAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDK 634
            A+  +   +++L    +     + + E     + LE+  Q  R E AQ  QE+    D 
Sbjct: 799 RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEE---DG 855

Query: 635 LGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSL 694
           L + Q R    E++  Q  R          QL++  +     L    + Q QL  E+Q L
Sbjct: 856 LQEDQERRRSQEQRRDQKWRW---------QLEEERKRRRHTLYAKPALQEQLRKEQQLL 906

Query: 695 SEEVDRLRTQ 704
            EE + L+ +
Sbjct: 907 QEEEEELQRE 916



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 95/525 (18%), Positives = 214/525 (40%), Gaps = 60/525 (11%)

Query: 78   KDLLRQQADKE-SEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTIND-----QSQYIHH 131
            + L RQ+ D++  E     RR+    + LE E+      H             + Q +H 
Sbjct: 1421 QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR 1480

Query: 132  LEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWIT 191
             E + KF +EE                   QQL+ Q ++   REQ L             
Sbjct: 1481 QERDRKFLEEE-------------------QQLRRQERDRKFREQELRSQEPERK---FL 1518

Query: 192  TGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKC--EIEESQLKFLRND 249
              E     +  +R F  +     +     ++ +    K   EE+   E EE QL     D
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERD 1578

Query: 250  LAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCL-------KCAQHEAVLSQTHTN-VH 301
              +++   + ++ Q + ++F+       R  G          K  + E +L +     +H
Sbjct: 1579 -RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH 1637

Query: 302  MQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQC 361
             Q  +R   E +  +      +    D  ++    + + +Q+LQ  EE    + +     
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQLRHDRDRK----FREEEQLLQEGEEQQLRRQER---- 1689

Query: 362  DQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQ 421
            D+  +E E+Q  R E+E    QE++ + +  ++++  +E +    +     + + + E  
Sbjct: 1690 DRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL---RQETEQEQLRRQERY 1746

Query: 422  VEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAK 481
             + + +E++    + ++++ Q   R+    +   + R +    + E D   +E  + R +
Sbjct: 1747 RKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQE 1806

Query: 482  TNRDLEIKDQEI------EKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQL 535
               + +++ Q+       E+ +++L+E +Q L QE+ +   A E+    T+     E Q 
Sbjct: 1807 -REEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQF--ATQEKSRREEQ- 1862

Query: 536  HLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDK 580
             L ++E+   +Q   ++ + + ++ QQ+E++  +++ ++++Q  K
Sbjct: 1863 ELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 93/501 (18%), Positives = 207/501 (41%), Gaps = 38/501 (7%)

Query: 86   DKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEELSG 145
            ++E ++   R RK         EE    +  +      ++ Q +   E E KF +EE   
Sbjct: 1403 EREQQLRQDRDRKF-------REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ- 1454

Query: 146  MKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTG--EDSGVGETSK 203
            ++ +      E E L Q+ + Q+     R++  L+    +          E     +  +
Sbjct: 1455 LRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPE 1514

Query: 204  RPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEI--EESQLKFLRNDLAEYQRTCEDLK 261
            R F  +     +     + L+ E+ +L  +E+ +   ++   KF   +    +R  + L 
Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQ-EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573

Query: 262  EQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVS 321
             Q + ++F L      R           + +  Q       Q  +R  +E + L      
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL------ 1627

Query: 322  VRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQA---ERLEKE 378
                L + ++++    E+ ++ L+   +   ++ +  ++ D+ RK  E +    E  E++
Sbjct: 1628 ----LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ 1683

Query: 379  LASQQEKRAI-EKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKE-KISAINQL 436
            L  Q+  R   E++   +   +ER+++  +  +  Q + +   + E++ +E +   + + 
Sbjct: 1684 LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ 1743

Query: 437  EEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKL 496
            E  +  L   ++   +   ++R Q       ++E  ++ RE +   +++ + K +E E+L
Sbjct: 1744 ERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQL 1803

Query: 497  RIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQ 556
            R E +E +   +Q   K     E+       L E E +L   RQE+D  +Q  ++E  A 
Sbjct: 1804 RQEREEQQLRPQQRDGKYRWEEEQLQ-----LEEQEQRL---RQERD--RQYRAEEQFAT 1853

Query: 557  ALQAQQREQELTQKIQQMEAQ 577
              ++++ EQEL Q+ +Q   Q
Sbjct: 1854 QEKSRREEQELWQEEEQKRRQ 1874



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 84/440 (19%), Positives = 174/440 (39%), Gaps = 52/440 (11%)

Query: 59   EDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDL 118
            E  R    E QQ H   + +  L+++     +    +RR+    +  E E+         
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER---- 1567

Query: 119  VHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTL 178
                  + Q +   E + KF  EE    + + +   +E+E   QQL+ Q  ++ LR++  
Sbjct: 1568 ------EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE---QQLRRQEGQQQLRQER- 1617

Query: 179  LDASGNMHNSWITTGEDSGVGETSK-RPFSHDNADFGKAASAGEQLELEKLKLTYEEKCE 237
             D         +   E+  +    + R F  +     +     +QL  ++ +   EE+  
Sbjct: 1618 -DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQL-RRQEREQQLRHDRDRKFREEEQL 1675

Query: 238  IEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTH 297
            ++E + + LR    E  R   + ++QL+ +E                     E    Q  
Sbjct: 1676 LQEGEEQQLRRQ--ERDRKFREEEQQLRRQE--------------------RERKFLQEE 1713

Query: 298  TNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKA 357
              +  Q +ER  +E + L       R      Q R    Y ++ +  Q+  E   ++ + 
Sbjct: 1714 QQLRRQELERKFREEEQL-------RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRR 1766

Query: 358  LIQCDQLRKELERQAERLEKELASQQEKRAI-EKDMMKKEITKE--REYMGSKMLILSQN 414
              +  + R+E + + ER E++L SQ+  R   E++ +++E  ++  R           + 
Sbjct: 1767 QERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEE 1826

Query: 415  IAQLEAQVEKVTKEKISAINQLEEIQSQLASR--EMDVTKVCGEMRYQLNKTNMEKDEAE 472
              QLE Q +++ +E+       E+  +Q  SR  E ++ +   + R Q  +  + ++   
Sbjct: 1827 QLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIR 1886

Query: 473  KEHREFRAKTNRDLEIKDQE 492
            ++ +E   +  +  EIK QE
Sbjct: 1887 RQQKE-EQRHRQVGEIKSQE 1905


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 143/693 (20%), Positives = 292/693 (42%), Gaps = 87/693 (12%)

Query: 84   QADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEEL 143
            + +K+ E    + R+     +L+HE T          ++ +  + I +L+   +  ++E 
Sbjct: 1162 EMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEK 1221

Query: 144  SGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSK 203
            S  K ++  V      ++Q +K++   E +     L+   N H S     + S    TS+
Sbjct: 1222 SEFKLELDDVT---SNMEQIIKAKANLEKMCRT--LEDQMNEHRSKAEETQRSVNDLTSQ 1276

Query: 204  RP-FSHDNADFGKAASAGEQL--ELEKLKLTYEEKCEIEESQLK-------FLRNDLAEY 253
            R     +N +  +     E L  +L + KLTY ++ E  + QL+        L + L   
Sbjct: 1277 RAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSA 1336

Query: 254  QRTCEDLKEQLKHK-----EFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERL 308
            +  C+ L+EQ + +     E     +  N          + +A+          + + + 
Sbjct: 1337 RHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1396

Query: 309  VKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKEL 368
            ++E ++ + A+ +  SSL  T+ R  +  E +   ++ S  A     K     D++  E 
Sbjct: 1397 LQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEW 1456

Query: 369  ERQAERLEKEL-ASQQEKRAIEKDMMK-----KEITKEREYMGSKMLILSQNIAQLEAQV 422
            +++ E  + EL +SQ+E R++  ++ K     +E  +  E    +   L + I+ L  Q+
Sbjct: 1457 KQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 1516

Query: 423  EKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKT 482
                K     I++LE+++ QL + +M++     E    L     +   A+ E  + +A+ 
Sbjct: 1517 GSSGK----TIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEI 1572

Query: 483  NRDLEIKDQEIE--------------------------------KLRIELDESKQHLEQE 510
             R L  KD+E+E                                K+  +L+E +  L   
Sbjct: 1573 ERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA 1632

Query: 511  QQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS-KEAKAQALQAQQRE----Q 565
             + AA A+++   L  LL +++ QL    +  D ++++ +  E +   LQA+  E     
Sbjct: 1633 NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVV 1692

Query: 566  ELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLK--------------EECCTLAKKLE 611
            E T++ +++  Q     +E+  LL SQNT L   K              EE     +  E
Sbjct: 1693 EQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAE 1752

Query: 612  QISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEE--QCVQHGRVHETMKQRLRQLDKH 669
            + ++K  ++ A +++E +   D    L+R  + +E+  + +QH R+ E  +  L+   K 
Sbjct: 1753 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQH-RLDEAEQIALKGGKKQ 1811

Query: 670  SQATAQQLVQLLSKQNQLLLERQSLSEEVDRLR 702
             Q    ++ +L   +N+L  E++  +E V  +R
Sbjct: 1812 LQKLEARVREL---ENELEAEQKRNAESVKGMR 1841



 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 131/642 (20%), Positives = 257/642 (40%), Gaps = 74/642 (11%)

Query: 67   ELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQS 126
            ++Q    V ++ + L  + +  +E++  +R+       L+ +      + DL  T+    
Sbjct: 912  KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRD------IDDLELTLAKVE 965

Query: 127  QYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQ---QQLKSQRQEETLREQTLLDASG 183
            +  H  E +VK   EE++G+   I  +  E + LQ   QQ     Q E  +  TL  A  
Sbjct: 966  KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 1025

Query: 184  NMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQL 243
             +        +  G  E  K+                 +++LE+ K   E   ++ +  +
Sbjct: 1026 KLEQQ---VDDLEGSLEQEKKV----------------RMDLERAKRKLEGDLKLTQESI 1066

Query: 244  KFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQ 303
              L ND        + L E+LK K+F L A        L  +    +A+ SQ       +
Sbjct: 1067 MDLENDK-------QQLDERLKKKDFELNA--------LNARIEDEQALGSQLQ-----K 1106

Query: 304  TIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQ 363
             ++ L    ++L   L + R++ A  ++  +    +++++ +  EEA    T   I+ ++
Sbjct: 1107 KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG-GATSVQIEMNK 1165

Query: 364  LRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVE 423
             ++E E Q  R + E A+ Q + A    + KK      E        L + I  L+   +
Sbjct: 1166 -KREAEFQKMRRDLEEATLQHE-ATAAALRKKHADSVAE--------LGEQIDNLQRVKQ 1215

Query: 424  KVTKEKISAINQLEEIQS---QLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRA 480
            K+ KEK     +L+++ S   Q+   + ++ K+C  +  Q+N           EHR    
Sbjct: 1216 KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMN-----------EHRSKAE 1264

Query: 481  KTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQ 540
            +T R +     +  KL+ E  E  + L++++   +      L  T+ L + + QL    +
Sbjct: 1265 ETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK 1324

Query: 541  EKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLK 600
             K+++  +         L  +Q E+E T+   +++    K  +E     T   T   +  
Sbjct: 1325 AKNALAHALQSARHDCDLLREQYEEE-TEAKAELQRVLSKANSEVAQWRTKYETDAIQRT 1383

Query: 601  EECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMK 660
            EE     KKL Q  Q+    +  ++ +         +LQ   E+L     +       + 
Sbjct: 1384 EELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALD 1443

Query: 661  QRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLR 702
            ++ R  DK      Q+  +  S+      E +SLS E+ +L+
Sbjct: 1444 KKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1485



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 86/414 (20%), Positives = 191/414 (46%), Gaps = 43/414 (10%)

Query: 310  KERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEK-------TKALIQCD 362
            KE   +      ++ +L  ++ R     E++  +LQ   +   +          A  +CD
Sbjct: 847  KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCD 906

Query: 363  QLRK---ELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLE 419
            QL K   +LE + + + + L  ++E        M  E+T ++  +  +   L ++I  LE
Sbjct: 907  QLIKNKIQLEAKVKEMNERLEDEEE--------MNAELTAKKRKLEDECSELKRDIDDLE 958

Query: 420  AQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFR 479
              + KV KEK +  N+++ +  ++A  +  + K+  E +          D+ + E  +  
Sbjct: 959  LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVN 1018

Query: 480  AKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTR 539
              T   +++ +Q+++ L   L++ K+ +  + ++A    E  L+LT+   ES   L   +
Sbjct: 1019 TLTKAKVKL-EQQVDDLEGSLEQEKK-VRMDLERAKRKLEGDLKLTQ---ESIMDLENDK 1073

Query: 540  QEKDSIQQSFSKEAKAQALQAQQREQ-----ELTQKIQQMEAQHDKTENEQYLLLTSQNT 594
            Q+ D  ++   K+ +  AL A+  ++     +L +K+++++A+ ++ E E    L ++ T
Sbjct: 1074 QQLD--ERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEE----LEAERT 1127

Query: 595  FLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGR 654
               K+++    L+++LE+IS++        S +      +  + Q+   +LEE  +Q   
Sbjct: 1128 ARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ--- 1184

Query: 655  VHETMKQRLRQLDKHSQATA---QQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
             HE     LR+  KH+ + A   +Q+  L   + +L  E+     E+D + + +
Sbjct: 1185 -HEATAAALRK--KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM 1235



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 120/534 (22%), Positives = 234/534 (43%), Gaps = 72/534 (13%)

Query: 203  KRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDL-- 260
            K  F+       K+ +  ++LE EK+    +EK +++  Q++  +++LA+ +  C+ L  
Sbjct: 853  KEEFTRLKEALEKSEARRKELE-EKMVSLLQEKNDLQ-LQVQAEQDNLADAEERCDQLIK 910

Query: 261  ------------KEQLKHKEFLLAANTCNR--VGGLCLKCAQHEAVLSQTHTNVHMQ--T 304
                         E+L+ +E + A  T  +  +   C +  +    L  T   V  +   
Sbjct: 911  NKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHA 970

Query: 305  IERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQ- 363
             E  VK   + M+ L  + + L   ++    A++Q    LQ  E+     TKA ++ +Q 
Sbjct: 971  TENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ 1030

Query: 364  -------------LRKELERQAERLEKELASQQEK-RAIEKDMMK-KEITKEREYMGSKM 408
                         +R +LER   +LE +L   QE    +E D  +  E  K++++  + +
Sbjct: 1031 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090

Query: 409  LILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEK 468
                ++   L +Q++K  KE  + I +LEE      +    V K+  ++  +L + +   
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150

Query: 469  DEAEKEHREFRAKTNRDLEI---KDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLT 525
            +EA          T+  +E+   ++ E +K+R +L+E+   L+ E   AAL ++    + 
Sbjct: 1151 EEA-------GGATSVQIEMNKKREAEFQKMRRDLEEAT--LQHEATAAALRKKHADSVA 1201

Query: 526  ELLGESEHQLHLTRQEKDSIQQSFSKEA------KAQALQAQQREQELTQKIQ-QMEAQH 578
            E LGE    L   +Q+ +  +  F  E         Q ++A+   +++ + ++ QM    
Sbjct: 1202 E-LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR 1260

Query: 579  DKTENEQYLL--LTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLG 636
             K E  Q  +  LTSQ     KL+ E   L+++L++      + I+QL++ K     +L 
Sbjct: 1261 SKAEETQRSVNDLTSQR---AKLQTENGELSRQLDE----KEALISQLTRGKLTYTQQLE 1313

Query: 637  KLQRRNEELEEQCVQHGRVHETMKQR-----LRQLDKHSQATAQQLVQLLSKQN 685
             L+R+ E  EE   ++   H     R     LR+  +       +L ++LSK N
Sbjct: 1314 DLKRQLE--EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1365



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 97/517 (18%), Positives = 225/517 (43%), Gaps = 63/517 (12%)

Query: 67   ELQQSHAVNQLKDLLRQQADKE-SEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQ 125
            ++++S+A     D  ++  DK  +E         S L S + E  ++ T  +L    N  
Sbjct: 1431 DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLST--ELFKLKNAY 1488

Query: 126  SQYIHHLEA---EVKFCKEELSGMKNKIQV---VVLENEGLQQQLKSQRQEETLREQTLL 179
             + + HLE    E K  +EE+S +  ++      + E E +++QL++++ E    +  L 
Sbjct: 1489 EESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKME---LQSALE 1545

Query: 180  DASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIE 239
            +A  ++ +       + G    ++  F+   A+  +  +  ++ E+E+ K  +    +  
Sbjct: 1546 EAEASLEH-------EEGKILRAQLEFNQIKAEIERKLAEKDE-EMEQAKRNHLRVVDSL 1597

Query: 240  ESQLKF---LRNDLAEYQRTCE-DLKE---QLKHKEFLLAANTCNRVGGLCLKCAQHEAV 292
            ++ L      RN+    ++  E DL E   QL H    +AA    +V  L       +  
Sbjct: 1598 QTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN-RMAAEAQKQVKSLQSLLKDTQIQ 1656

Query: 293  LSQT-HTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEAN 351
            L      N  ++    +V+ R++L+ A +    ++ +  +R     EQ  ++++ SE   
Sbjct: 1657 LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ--ELIETSERVQ 1714

Query: 352  F----------EKTKALIQCDQLRKELERQAERLEKELASQQEKRAI-EKDMMKKEITKE 400
                       +K K      QL+ E+E   +      A ++ K+AI +  MM +E+ KE
Sbjct: 1715 LLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN--AEEKAKKAITDAAMMAEELKKE 1772

Query: 401  REYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEI-----QSQLASREMDVTKVCG 455
            ++         S ++ +++  +E+  K+    +++ E+I     + QL   E  V ++  
Sbjct: 1773 QD--------TSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEN 1824

Query: 456  EMRYQLNKT-----NMEKDEAEKEHREFRAKTNRDLEIKDQE-IEKLRIELDESKQHLEQ 509
            E+  +  +       M K E   +   ++ + +R   ++ Q+ ++KL++++   K+  E+
Sbjct: 1825 ELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEE 1884

Query: 510  EQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQ 546
             +++A     +  ++   L E+E +  +   + + ++
Sbjct: 1885 AEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLR 1921



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 68/306 (22%), Positives = 132/306 (43%), Gaps = 38/306 (12%)

Query: 429  KISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKD-EAEKEHREFRAKTNRDLE 487
            K   +  LEE++ +  SR   +T++  + R  L +   +K  E        +      + 
Sbjct: 766  KAGLLGLLEEMRDERLSRI--ITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMG 823

Query: 488  IKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESE-------HQLHLTRQ 540
            +K+    KL  ++    +  E+E++ A++ +EE  RL E L +SE        ++    Q
Sbjct: 824  VKNWPWMKLYFKIKPLLKSAEREKEMASM-KEEFTRLKEALEKSEARRKELEEKMVSLLQ 882

Query: 541  EKDSIQQSFSKEAKAQALQAQQREQELTQKIQ---QMEAQHDKTENEQYLLLTSQNTFLT 597
            EK+ +Q     E    A   ++ +Q +  KIQ   +++  +++ E+E+ +     N  LT
Sbjct: 883  EKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEM-----NAELT 937

Query: 598  ----KLKEECCTLAK----------KLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNE 643
                KL++EC  L +          K+E+    T +++  L++E     + + KL +  +
Sbjct: 938  AKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997

Query: 644  ELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQL-----LSKQNQLLLERQSLSEEV 698
             L+E   Q     +  + ++  L K      QQ+  L       K+ ++ LER     E 
Sbjct: 998  ALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEG 1057

Query: 699  DRLRTQ 704
            D   TQ
Sbjct: 1058 DLKLTQ 1063


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 150/716 (20%), Positives = 290/716 (40%), Gaps = 128/716 (17%)

Query: 70   QSHAVNQLKDLLRQ----QADKESEVSPSRRRKMSPLRSLEH-EETNMPTMHDLVHTIND 124
            QS A   L D L+     Q++KES  S  +++     R LE  EE ++    ++   ++ 
Sbjct: 2088 QSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDA 2147

Query: 125  QSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGN 184
              +   HLE  +            +IQV + + +   QQL     +E L       A+  
Sbjct: 2148 LRREKVHLEETI-----------GEIQVTLNKKDKEVQQL-----QENLDSTVTQLAAFT 2191

Query: 185  MHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLK 244
               S +    D  + E  K         + +  S   Q + E+++L  E+ C + + QL+
Sbjct: 2192 KSMSSLQDDRDRVIDEAKK---------WERKFSDAIQSKEEEIRLK-EDNCSVLKDQLR 2241

Query: 245  FLRNDLAEYQRTCEDLK------EQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHT 298
             +   + E +     L+      E     E  L    C+ + G      +++ +LSQ   
Sbjct: 2242 QMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQG------ENKELLSQLEE 2295

Query: 299  NVHM-----QTIERLVKERDDLMSALVSVRSSLADTQQREAS-----------------A 336
              H+       + +L  E   L   L  + +SL   ++++ +                 +
Sbjct: 2296 TRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFS 2355

Query: 337  YEQVKQVLQIS--------EEANFEKTKAL-----------IQCDQLRKELERQAERLEK 377
            YEQ++  LQ S        EE N ++ K +           +   +LR++ +++ + LE 
Sbjct: 2356 YEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELEN 2415

Query: 378  ELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLE 437
             L+ ++E+  + ++  KK + K  + M +   I  +NI Q +AQ++   K   S  N  +
Sbjct: 2416 LLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQ-KAQLDSFVKSMSSLQNDRD 2474

Query: 438  EI---QSQLASREMDV---------------TKVCGE---MRYQLNKTNMEKDEAEKEHR 476
             I     QL  R + +                K+  E   +R  ++  N E  + + E  
Sbjct: 2475 RIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELI 2534

Query: 477  EFRAKTNRDLEIKD-QEIEKLRIELDESKQ------HLEQEQQKAALAREECLRLTELLG 529
            ++R   N+ + IKD Q+ + L ++L ++K+       LE++ +++  A E+  R    L 
Sbjct: 2535 QYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQ 2594

Query: 530  ESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLL 589
            E +  L    +E +S++ S S+  +   + A Q E  L     Q++ + ++      L  
Sbjct: 2595 EEKQDLS---KEIESLKVSISQLTRQ--VTALQEEGTLGLYHAQLKVKEEEVHRLSALFS 2649

Query: 590  TSQNTFLTKLKEECCT---LAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELE 646
            +SQ       +E  C     AKK+ +I  K + E+  L  +        G ++   E  E
Sbjct: 2650 SSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDA-------GIMRNETETAE 2702

Query: 647  EQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLR 702
            E+  +  R    M+Q+L  + K ++    Q+       + L   R   +EE+D L+
Sbjct: 2703 ERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELK 2758



 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 154/743 (20%), Positives = 315/743 (42%), Gaps = 107/743 (14%)

Query: 27   RSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAWPEL----QQSHAVNQLKDLLR 82
            R +  L   ++E D  + E + +++      NE+  +   E+    +Q + +++ ++  +
Sbjct: 887  RDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKK 946

Query: 83   QQADKESEVSPSRRR---KMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVKFC 139
            +Q ++++EVS   ++   +MSP   +  EE                      L+ E    
Sbjct: 947  EQVEEDNEVSSGLKQNYDEMSPAGQISKEE----------------------LQHEFDLL 984

Query: 140  KEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVG 199
            K+E    K K+Q  ++  + L Q++   R EE L    L D S           ++  + 
Sbjct: 985  KKENEQRKRKLQAALINRKELLQRVS--RLEEELAN--LKDESK----------KEIPLS 1030

Query: 200  ETSKRPFSHD--NADFGKAASAGEQLELE-KLKLTYEEKCEIEESQLKFLRNDLAEYQRT 256
            ET +     D  N ++ +     +  E+E  LK T  EK    E +L+ +R DL E    
Sbjct: 1031 ETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEK----EVELQHIRKDLEEKLAA 1086

Query: 257  CEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQ---THTNVHMQTIERLVKERD 313
             E  +  +K     L   T N++  L  + ++++A++ +   ++T+        LVKE  
Sbjct: 1087 EEQFQALVKQMNQTLQDKT-NQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETV 1145

Query: 314  DLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQ-----LRKEL 368
             +               + +  A E+ K+ LQ   +      KA+++  Q     LR+EL
Sbjct: 1146 VISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREEL 1205

Query: 369  ERQAE---RLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQ-----NIAQLEA 420
            ++Q +   RL+++   Q ++     D +++   + RE +  K+    Q     +   LE 
Sbjct: 1206 KQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEE 1265

Query: 421  QVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFR- 479
             + K T++  +       +     S   D + + G       K  +++ EAEK   E + 
Sbjct: 1266 PLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKV 1325

Query: 480  AKTNRDLEIKDQEIEKLRIELD------ESKQHLEQEQQKAALAREECLRLTELLGESEH 533
            + T  +L  K +E+ +L+ +++      ES + +  E +  A + ++ L  ++L      
Sbjct: 1326 SSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLE 1385

Query: 534  QLHLTRQEKDSIQQSFSK-EAKAQALQAQQREQEL------TQKIQQ---MEAQHDKTEN 583
             L   + + D +Q+  SK E     L  Q  E+E       T+ I+Q   ++A H + E 
Sbjct: 1386 HLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEM 1445

Query: 584  EQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNE 643
            +        +  + +L+ E C + +K E+I +++R++  Q+ ++ +       +  + N+
Sbjct: 1446 QA----KEHDERIKQLQVELCEMKQKPEEIGEESRAK-QQIQRKLQAALISRKEALKENK 1500

Query: 644  ELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQ-----------LVQ-----LLSKQNQL 687
             L+E+        E + + L   D  SQ +AQ            L+Q     L+++ ++ 
Sbjct: 1501 SLQEELSLARGTIERLTKSLA--DVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRS 1558

Query: 688  LLERQSLSEEVDRLRTQLPSMPQ 710
            LLE QSLS   + L+  L  + +
Sbjct: 1559 LLENQSLSSSCESLKLALEGLTE 1581



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 136/736 (18%), Positives = 298/736 (40%), Gaps = 68/736 (9%)

Query: 12   EILGQYQRSLREHASRSIHQLTCALKEGDVTIG---EDAPNLSFST----SVGNEDARTA 64
            +I G   +     A+      T   +EG  +I    E+  +LS ST    S     A++A
Sbjct: 1762 QIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSA 1821

Query: 65   WPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTIND 124
             P + +  + +   +   QQ D+  E       +++ L   E ++ N      L +  N 
Sbjct: 1822 NPAVSKDFSSHDEINNYLQQIDQLKE-------RIAGLE--EEKQKNKEFSQTLENEKNT 1872

Query: 125  QSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGN 184
                I   + E+K  +EE++ M    Q +  E   + +  ++  +E+   E+ L++    
Sbjct: 1873 LLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAE 1932

Query: 185  MHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLK 244
            ++ S     +D    +        +  +  K  S  E+ + + +K   + + EI +  L+
Sbjct: 1933 LNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLE 1992

Query: 245  FLRNDLAE--YQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHM 302
             ++    E   +   ++L+E LK K+          V  L   C +++  +S     V  
Sbjct: 1993 KIQGAQKEPGNKSHAKELQELLKEKQ--------QEVKQLQKDCIRYQEKISALERTVKA 2044

Query: 303  QTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCD 362
                +   ++D     L   + +LA   +    A  ++     + ++   E  + L    
Sbjct: 2045 LEFVQTESQKD-----LEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNL 2099

Query: 363  QLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQV 422
            +L+KEL+   E ++ ++  + E      +  +++  KE++ M  K+  L +    LE  +
Sbjct: 2100 KLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETI 2159

Query: 423  EKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFR--- 479
             ++         +++++Q  L S    +      M    +  +   DEA+K  R+F    
Sbjct: 2160 GEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAI 2219

Query: 480  AKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTR 539
                 ++ +K+     L+ +L +   H+  E+ K  ++R   L   + + ES+ Q  +  
Sbjct: 2220 QSKEEEIRLKEDNCSVLKDQLRQMSIHM--EELKINISR---LEHDKQIWESKAQTEVQL 2274

Query: 540  QEK--DSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLT 597
            Q+K  D++Q   +KE  +Q  + +        ++ ++E++    +++    LT  +  L 
Sbjct: 2275 QQKVCDTLQGE-NKELLSQLEETRHLYHSSQNELAKLESELKSLKDQ----LTDLSNSLE 2329

Query: 598  KLKEECCTLA-----------------KKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQR 640
            K KE+   L                  ++LE   Q +R   ++L +E      K+  L  
Sbjct: 2330 KCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLS 2389

Query: 641  RNEE-----LEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLS 695
              EE     + E   QH +  + ++  L Q ++ +    ++  + + K NQL+   +++ 
Sbjct: 2390 GKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIK 2449

Query: 696  EEVDRLRTQLPSMPQS 711
            +E  + + QL S  +S
Sbjct: 2450 KENIQQKAQLDSFVKS 2465



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 95/430 (22%), Positives = 194/430 (45%), Gaps = 66/430 (15%)

Query: 305  IERLVKERDDLMSALVSVRSSLADTQQREASAYEQV-KQVLQISEEANFEKTKALIQCDQ 363
            ++ +  E+ +L   + S  S L    +      EQ+ KQ L+I E       +A +  + 
Sbjct: 1311 LKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEI-ESLKTVSHEAEVHAES 1369

Query: 364  LRKELERQAERLEKELASQQEKRAIEK--DMMKKEITKEREYMGSKMLILSQNIAQLEAQ 421
            L+++LE      + ++A  +  R ++   D ++K I+K+ E +      LS  +++ EA 
Sbjct: 1370 LQQKLESS----QLQIAGLEHLRELQPKLDELQKLISKKEEDVS----YLSGQLSEKEAA 1421

Query: 422  VEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAK 481
            + K+  E I   + ++ + +QL  +  +  +   +++ +L +   + +E  +E R     
Sbjct: 1422 LTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA---- 1477

Query: 482  TNRDLEIKDQEIEKLRIELDESKQHLEQE---QQKAALAREECLRLTELLGESEHQLHLT 538
                   K Q   KL+  L   K+ L++    Q++ +LAR    RLT+ L + E Q+   
Sbjct: 1478 -------KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQ 1530

Query: 539  RQEKDSI--QQSFSKEAKAQALQAQQRE----QELTQKIQQME-AQHDKTENEQYLLLTS 591
             +EKD++  + +  +E + + +    R     Q L+   + ++ A    TE+++ L+   
Sbjct: 1531 NKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEI 1590

Query: 592  QNTFLTKLKE-------------ECCTLAKKLEQIS---QKTRSEIAQLSQEKRYTYDKL 635
            ++   +K+ E             E   L +  E +S   ++ +  +  + QEK+  Y KL
Sbjct: 1591 ESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKL 1650

Query: 636  GKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLS 695
               +   +E E+Q  +  +  E MK+++R+  K             SKQ ++L     L 
Sbjct: 1651 RSTEANKKETEKQLQEAEQEMEEMKEKMRKFAK-------------SKQQKIL----ELE 1693

Query: 696  EEVDRLRTQL 705
            EE DRLR ++
Sbjct: 1694 EENDRLRAEV 1703



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 127/629 (20%), Positives = 253/629 (40%), Gaps = 99/629 (15%)

Query: 100 SPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVK-FCKEELSGMKNKIQVVVLENE 158
           +PL    H+E++M   +     + ++  Y   L  E+K   +++   ++ K + +  E +
Sbjct: 28  APLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERK 87

Query: 159 GLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAAS 218
               ++K  +     +  +L        N +I   +  G       P S +       +S
Sbjct: 88  AADNKIKKLKLHAKAKLTSL--------NKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSS 139

Query: 219 AGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEY--QRTCE-----DLKEQLKHKEFLL 271
             E++E+EK+K   +EK E+  +    L    AE   Q + E      +K+QL+ KE  +
Sbjct: 140 TEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFI 199

Query: 272 AANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQ 331
           +                 +A LSQT      Q  +++V+E+D      V +         
Sbjct: 200 ST---------------LQAQLSQTQAE---QAAQQVVREKDARFETQVRLHED------ 235

Query: 332 REASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKD 391
                     ++LQ+  +A+ E      +  Q  + L+R+ E  E+ L      RA   D
Sbjct: 236 ----------ELLQLVTQADVE-----TEMQQKLRVLQRKLEEHEESLVG----RAQVVD 276

Query: 392 MMKKEITKEREYMGSKMLILSQNIAQLEAQ----VEKVTKEKISAINQLEEIQSQLASRE 447
           ++++E+T   +    +  ILSQ + Q+EA+       V  E+  +   LE+++ ++A R+
Sbjct: 277 LLQQELTAAEQ----RNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332

Query: 448 MDVTKVCGEMRY---QLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESK 504
           +    +  EM +   Q  +    + E E  +     K   ++E K   I  L        
Sbjct: 333 LSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSL-------- 384

Query: 505 QHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQRE 564
           Q   QE Q A  A ++  + ++LL +   Q     Q   +IQQ           Q QQ+ 
Sbjct: 385 QKTGQELQSACDALKD--QNSKLLQDKNEQ---AVQSAQTIQQLED--------QLQQKS 431

Query: 565 QELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQK------TR 618
           +E++Q + ++  Q  +T ++               +E   +L K++ ++  +      + 
Sbjct: 432 KEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSS 491

Query: 619 SEIAQLSQEKRYTYDKLGKLQRRNEELE-EQCVQHGRVHETMKQRLRQLDKHSQATAQQL 677
            E+ +L  E      ++  L+ +N   E ++ V    + +   +R    ++  Q   +  
Sbjct: 492 IELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENT 551

Query: 678 VQLLSKQ-NQLLLERQSLSEEVDRLRTQL 705
                K+ + LLLE +   EE+  L+ QL
Sbjct: 552 FSQKHKELSVLLLEMKEAQEEIAFLKLQL 580



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 152/737 (20%), Positives = 297/737 (40%), Gaps = 96/737 (13%)

Query: 11   EEILGQYQRSLREHASRSIH--QLTCALKEGDVTIGEDAPNL-SFSTSVGNEDARTAWPE 67
            + I+G YQ+    H S  +   QL       +  + E+   L S    + +E+A+     
Sbjct: 2474 DRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAEL 2533

Query: 68   LQQSHAVNQL--------KDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLV 119
            +Q    +NQ+        K LL  Q  +  E+     +    L+  E EE N     DL 
Sbjct: 2534 IQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLK--ESEEAN----EDLR 2587

Query: 120  HTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQ---RQEETLREQ 176
             + N   +    L  E++  K  +S +    QV  L+ EG      +Q   ++EE  R  
Sbjct: 2588 RSFNALQEEKQDLSKEIESLKVSISQLTR--QVTALQEEGTLGLYHAQLKVKEEEVHRLS 2645

Query: 177  TLLDAS----GNMHNSWITTGEDSG--VGETS---KRPFSHDNADFG----KAASAGEQL 223
             L  +S      +    +   +++   VGE     K+   H + D G    +  +A E++
Sbjct: 2646 ALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERV 2705

Query: 224  -ELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKH---------KEFLLAA 273
             EL +  +  E+K  +   + K L   +  + R+   L+    H         +++  + 
Sbjct: 2706 AELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASL 2765

Query: 274  NTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQRE 333
                ++    L   + +A+LS+T  +++  T E  +   + L   L+S    L     + 
Sbjct: 2766 KELAQLKEQGLLNRERDALLSETAFSMN-STEENSLSHLEKLNQQLLSKDEQLLHLSSQL 2824

Query: 334  ASAYEQVKQVLQISEEANFEKTKALIQC--DQLRKELE--RQAERLEKELASQQEKRAIE 389
              +Y QV+         +F K  A +Q   D L  ELE  R++E  ++  A+Q      E
Sbjct: 2825 EDSYNQVQ---------SFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAE 2875

Query: 390  KDMMKKEITK---EREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASR 446
               +KK ++    +R+ +  ++  L Q   Q+  ++ ++   K     QL+E Q +  + 
Sbjct: 2876 VQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKA----QLQEYQDKTKAF 2931

Query: 447  EMDVTKVCGE---MRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDES 503
            ++   ++  E    +++L++  MEK   E   R  + +    +  KDQ++  L+  + E 
Sbjct: 2932 QIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIREL 2991

Query: 504  KQHLEQEQQKAALAREECLRLTELLGESEHQL-----HLTRQEKDSIQQSFSKEAKAQAL 558
            +    Q Q      + +    T    +    L      L  Q  DS+++   KE + Q L
Sbjct: 2992 RSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQL 3051

Query: 559  Q---AQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQI-S 614
                +Q  E++ T  IQ  +      EN+Q+            L   C  L K+++++ +
Sbjct: 3052 NSNFSQLLEEKNTLSIQLCDTSQSLRENQQH---------YGDLLNHCAVLEKQVQELQA 3102

Query: 615  QKTRSEIAQ-LSQEKRYTY-----DKLGKLQRRNEELEEQ-CVQHGRVHETMKQRLRQLD 667
                 ++A    QEK   +     ++L + Q+   E ++Q C     V+E  K  L + +
Sbjct: 3103 GPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRK--LLEEE 3160

Query: 668  KHSQATAQQLVQLLSKQ 684
            +  +  A+  + +  +Q
Sbjct: 3161 RDQRVAAENALSVAEEQ 3177



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 114/522 (21%), Positives = 220/522 (42%), Gaps = 81/522 (15%)

Query: 210  NADFGKAASAGEQLELEKLKLTYEEKCEIEE--SQLKFLRNDLAEYQRTCE-DLKEQLKH 266
            NAD   +A      E ++L    +E   + E  +Q+K L  +LAE +R    D + Q  H
Sbjct: 731  NADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAH 790

Query: 267  KEFLLAANTCNRVGGLCLKCAQHEA---VLSQTHTNVHMQTIERLVKERDDLMSALVSVR 323
               L       ++  L ++    +    VL     +V +Q  E+    R  L S L +  
Sbjct: 791  DNLLT-----EQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRS-LQSQLQNKE 844

Query: 324  SSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQ- 382
            S + +  +R      +V+++ Q   +   E TK     DQL  E +R  E L++ +  + 
Sbjct: 845  SEVLEGAERVRHISSKVEELSQALSQKELEITKM----DQLLLEKKRDVETLQQTIEEKD 900

Query: 383  QEKRAIEKDMMKK--EITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLE--- 437
            Q+   I   M +K  ++ +E+  +G ++  L + +  L ++ E+  KE++   N++    
Sbjct: 901  QQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQL-NLLSRAEEAKKEQVEEDNEVSSGL 959

Query: 438  -----------EIQSQLASREMDVTKVCGEMRYQ------LNKTNMEKDEAEKEHREFRA 480
                       +I  +    E D+ K   E R +      +N+  + +  +  E      
Sbjct: 960  KQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANL 1019

Query: 481  KTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREEC-LRLTELLGESEHQLHLTR 539
            K     EI   E E  R E++E K++ E  ++      +E  + L + + E E +L   R
Sbjct: 1020 KDESKKEIPLSETE--RGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIR 1077

Query: 540  QEKDSIQQSFSKEAKAQAL--QAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNT--- 594
            ++   +++  + E + QAL  Q  Q  Q+ T +I  ++A+  + +     L+TS      
Sbjct: 1078 KD---LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASD 1134

Query: 595  -----------------------FLTKLKEECCTLAKKLEQISQK------TRSEIAQLS 625
                                   +  +L+E+   L K+ EQ+ +K      +R  I + +
Sbjct: 1135 GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKA 1194

Query: 626  QEK-RYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQL 666
            QEK R+  ++L + +     L+EQ  +  + +E +  +LRQL
Sbjct: 1195 QEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQL 1236



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 135/648 (20%), Positives = 259/648 (39%), Gaps = 127/648 (19%)

Query: 68  LQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQ 127
           +Q +  + QL+D L+Q   K  E+S    R   PL+  +HE  +  +  D+    N+ +Q
Sbjct: 414 VQSAQTIQQLEDQLQQ---KSKEISQFLNRL--PLQ--QHETASQTSFPDVY---NEGTQ 463

Query: 128 YIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHN 187
            +          +E ++ ++ +  VV LENE     L S   EE   E   L +   +  
Sbjct: 464 AV---------TEENIASLQKR--VVELENEKGALLLSSIELEELKAENEKLSSQITLLE 512

Query: 188 SWITTGE-DSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKFL 246
           +   TGE D  V E S    ++      K +S+ E+   + L+ T+ +K      +L  L
Sbjct: 513 AQNRTGEADREVSEISIVDIAN------KRSSSAEESGQDVLENTFSQK----HKELSVL 562

Query: 247 RNDLAEYQRTCEDLKEQLKHKEF------LLAANTCNRVGGLCLKCAQHEAVLSQTHTNV 300
             ++ E Q     LK QL+ K        +L      ++ G  +   + +  L  T  + 
Sbjct: 563 LLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDF 622

Query: 301 HMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYE--------QVKQVLQISEEANF 352
            +   E          S+L +V    A T+ +  ++ E        ++K   Q  +++  
Sbjct: 623 PLMPNEE---------SSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKS-L 672

Query: 353 EKTKALIQCDQLRKELER-QAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLIL 411
                + QC Q   ELER +++ LE EL   + +   EK++ +K   KE           
Sbjct: 673 SAVPDIGQCHQ--DELERLKSQILELELNFHKAQEIYEKNLDEK--AKE----------- 717

Query: 412 SQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEA 471
             N+ QL  + +K      SA   L E + QL S+  +++ V  E+R Q+ +  M   EA
Sbjct: 718 ISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVT-ELRAQVKQLEMNLAEA 776

Query: 472 EKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGES 531
           E++                              + L+ E Q A            LL E 
Sbjct: 777 ERQ------------------------------RRLDYESQTAH---------DNLLTEQ 797

Query: 532 EHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTS 591
            H L +  + KD   +    E     LQ  ++    +  I+ +++Q    E+E       
Sbjct: 798 IHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQ----STLIRSLQSQLQNKESE------- 846

Query: 592 QNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQ 651
               + +  E    ++ K+E++SQ    +  ++++  +   +K   ++   + +EE+  Q
Sbjct: 847 ----VLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQ 902

Query: 652 HGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVD 699
              +  +M +++ QL++   +   ++  L  + N L    ++  E+V+
Sbjct: 903 VTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVE 950



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 131/660 (19%), Positives = 269/660 (40%), Gaps = 74/660 (11%)

Query: 57   GNEDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMH 116
            G E  R   P+L      ++L+ L+ ++ +  S +S     K + L  ++ E      + 
Sbjct: 1383 GLEHLRELQPKL------DELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLI 1436

Query: 117  DLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQ 176
              +HT  +     H  +  +K  + EL  MK K + +  E+   +QQ++ + Q   +  +
Sbjct: 1437 KALHTQLEMQAKEH--DERIKQLQVELCEMKQKPEEIGEESRA-KQQIQRKLQAALISRK 1493

Query: 177  TLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLE---LEKLKLTYE 233
              L  + ++        E+  +   +    +   AD     SA  + +   L +L L  E
Sbjct: 1494 EALKENKSLQ-------EELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQE 1546

Query: 234  EKCE-IEESQLKFLRNDLAEYQRTCEDLKEQLK----HKEFLLAANTCNRVGGLCLKCAQ 288
            E+ + I E     L N       +CE LK  L+     KE L+            ++  +
Sbjct: 1547 ERDKLITEMDRSLLENQ--SLSSSCESLKLALEGLTEDKEKLVKE----------IESLK 1594

Query: 289  HEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQ--- 345
               +   T      +  + L KE + L+ +  +V S+ A+  Q    A  Q KQ L    
Sbjct: 1595 SSKIAESTEWQ---EKHKELQKEYEILLQSYENV-SNEAERIQHVVEAVRQEKQELYGKL 1650

Query: 346  ISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEK---RAIEKDMMKKEITKERE 402
             S EAN ++T+  +Q  +  +E+E   E++ K   S+Q+K      E D ++ E+    +
Sbjct: 1651 RSTEANKKETEKQLQ--EAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708

Query: 403  YMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLN 462
                 M  L  + A ++ ++E+V  E  +   + + + S+  S   +V  +  ++   ++
Sbjct: 1709 TAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVS 1768

Query: 463  K-TNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRI-------ELDESKQHLEQEQQKA 514
            K  N+E  E          +  + +  + +E + L +       E   S +       K 
Sbjct: 1769 KQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKD 1828

Query: 515  ALAREEC---LRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKI 571
              + +E    L+  + L E    L   +Q+     Q+   E      Q   ++ EL  K+
Sbjct: 1829 FSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGEL--KM 1886

Query: 572  QQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYT 631
             Q E       N+Q   +  + + +TKLKE   T  ++ + + ++  +++A+L+      
Sbjct: 1887 LQEEVTKMNLLNQQ---IQEELSRVTKLKE---TAEEEKDDLEERLMNQLAELNGSIGNY 1940

Query: 632  YDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLER 691
               +   Q +NE LE +        + +K+ + +L++  Q   ++  ++ S+  +  LE+
Sbjct: 1941 CQDVTDAQIKNELLESEM-------KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEK 1993



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 66/299 (22%), Positives = 134/299 (44%), Gaps = 41/299 (13%)

Query: 410 ILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKD 469
           I+ Q   QL+ + E + +E+ +A N++++++    ++   + K   EM+ Q       + 
Sbjct: 67  IIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEP 126

Query: 470 EAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLG 529
           ++E++     +K ++    ++ EIEK++ +L E ++ +   Q +   A+       E   
Sbjct: 127 QSEEQ----LSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQ------AEQPA 176

Query: 530 ESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLL 589
           +S  ++      K  +Q+   KE     LQAQ  + +  Q  QQ+  + D     Q    
Sbjct: 177 QSSTEMEEFVMMKQQLQE---KEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQ---- 229

Query: 590 TSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQC 649
                   +L E+        E +   T++++    Q+K      L  LQR+ EE EE  
Sbjct: 230 -------VRLHED--------ELLQLVTQADVETEMQQK------LRVLQRKLEEHEESL 268

Query: 650 VQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSM 708
           V   +V + ++Q L   ++ +Q  +QQL Q+ ++ N L   R ++  E +  +  L  M
Sbjct: 269 VGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTL---RNTVETEREESKILLEKM 324



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 99/516 (19%), Positives = 219/516 (42%), Gaps = 71/516 (13%)

Query: 221 EQLELEKLKLTYEEKCEIEESQ--LKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNR 278
           +Q+E E   L    + E EES+  L+ +  ++AE + +  +L+E++ H           +
Sbjct: 297 QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHH-----LLEQFEQ 351

Query: 279 VGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYE 338
            G    +     + L Q H             E ++  S ++S++ +  + Q    +  +
Sbjct: 352 AGQAQAELESRYSALEQKHK-----------AEMEEKTSHILSLQKTGQELQSACDALKD 400

Query: 339 QVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEIT 398
           Q  ++LQ       +K +  +Q  Q  ++LE Q ++  KE++    +  +++     + +
Sbjct: 401 QNSKLLQ-------DKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTS 453

Query: 399 KEREYMGSKMLILSQNIAQLEAQVEKVTKEK----ISAINQLEEIQSQLASREMDVTKV- 453
               Y      +  +NIA L+ +V ++  EK    +S+I +LEE++++       +T + 
Sbjct: 454 FPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSI-ELEELKAENEKLSSQITLLE 512

Query: 454 ----CGEMRYQLNK------TNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDES 503
                GE   ++++       N     AE+  ++    T      K +E+  L +E+ E+
Sbjct: 513 AQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENT---FSQKHKELSVLLLEMKEA 569

Query: 504 KQH-----LEQEQQKAALAREECL---RLTELLGESEHQLHLTRQEKDSIQQSFSKEAKA 555
           ++      L+ + ++A  A  E L    + ++ GE    + +    +D+ Q       + 
Sbjct: 570 QEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEE 629

Query: 556 QALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQ 615
            +L A ++EQ  T        +H    +E+ + L      L   K++       +  I Q
Sbjct: 630 SSLPAVEKEQAST--------EHQSRTSEE-ISLNDAGVELKSTKQDGDKSLSAVPDIGQ 680

Query: 616 KTRSEIAQLSQ---EKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQA 672
             + E+ +L     E    + K  ++  +N  L+E+  +   +++ +++  +  D +S A
Sbjct: 681 CHQDELERLKSQILELELNFHKAQEIYEKN--LDEKAKEISNLNQLIEEFKKNADNNSSA 738

Query: 673 TAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSM 708
                  L  +++QLL + + LS  V  LR Q+  +
Sbjct: 739 ----FTALSEERDQLLSQVKELS-MVTELRAQVKQL 769



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 93/466 (19%), Positives = 173/466 (37%), Gaps = 59/466 (12%)

Query: 7    NSTLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAWP 66
            N  L+E+  +Y  SL+E A   + +     +E D  + E A    FS +   E++ +   
Sbjct: 2751 NEELDELKRKYDASLKELAQ--LKEQGLLNRERDALLSETA----FSMNSTEENSLSHLE 2804

Query: 67   ELQQS--HAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTIND 124
            +L Q       QL  L  Q  D  ++V    +   S     +H    +            
Sbjct: 2805 KLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQR 2864

Query: 125  QSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGN 184
             +       AEV+  K+ +S ++N    ++ E + LQQQ     QE T  E   L A   
Sbjct: 2865 SAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEIT--ELHPLKAQLQ 2922

Query: 185  MHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLK 244
             +       + +   +  +     +N  +        Q EL +L++  +   EI E ++K
Sbjct: 2923 EYQ------DKTKAFQIMQEELRQENLSW--------QHELHQLRME-KSSWEIHERRMK 2967

Query: 245  FLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQT 304
                   +Y     D  +QL H + L+     +      LK  Q++   S   T+     
Sbjct: 2968 ------EQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLK-VQYQRQAS-PETSASPDG 3019

Query: 305  IERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQL 364
             + LV E + L + L     SL +  Q+E    +      Q+ EE N    +       L
Sbjct: 3020 SQNLVYETELLRTQL---NDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSL 3076

Query: 365  RKE-------------LERQAERLEK-------ELASQQEKRAIEKDMMKKEITKEREYM 404
            R+              LE+Q + L+           + QEK  + +    +E+ + ++  
Sbjct: 3077 RENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSF 3136

Query: 405  G---SKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASRE 447
                 ++    Q + +L   +E+   ++++A N L   + Q+   E
Sbjct: 3137 SEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLE 3182



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 96/540 (17%), Positives = 204/540 (37%), Gaps = 65/540 (12%)

Query: 31   QLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESE 90
            +L C  KE    +GE    L       + DA     E +   A  ++ +L R   + E +
Sbjct: 2661 ELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETET--AEERVAELARDLVEMEQK 2718

Query: 91   ---VSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVK-FCKEELSGM 146
               V+   +   + ++S     +++    D  H   +  +     +A +K   + +  G+
Sbjct: 2719 LLMVTKENKGLTAQIQSFGRSMSSLQNSRD--HANEELDELKRKYDASLKELAQLKEQGL 2776

Query: 147  KNKIQVVVLEN----------------EGLQQQLKSQRQEETLREQTLLDASGNMHNSW- 189
             N+ +  +L                  E L QQL S + E+ L   + L+ S N   S+ 
Sbjct: 2777 LNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLS-KDEQLLHLSSQLEDSYNQVQSFS 2835

Query: 190  -----ITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLK 244
                 +    D    E  K   S +      A  +    E++ LK          +  LK
Sbjct: 2836 KAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLK 2895

Query: 245  FLRNDLAEYQRTCEDLKE-----------QLKHKEFLLAANTCNRVGGLCLKCAQHEAVL 293
             L+N   +Y +  +++ E           Q K K F +      R   L  +   H+  +
Sbjct: 2896 ELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEEL-RQENLSWQHELHQLRM 2954

Query: 294  SQTHTNVHMQTIER----LVKERDDLMSALVSV----RSSLADTQQREASAYEQVKQVLQ 345
             ++   +H + ++      + ++D  +S L ++    RSS + TQ  +     Q      
Sbjct: 2955 EKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETS 3014

Query: 346  ISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMG 405
             S + +      + + + LR +L    + +      Q+E R  + +    ++ +E+  + 
Sbjct: 3015 ASPDGS---QNLVYETELLRTQLNDSLKEIH-----QKELRIQQLNSNFSQLLEEKNTLS 3066

Query: 406  SKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTN 465
             ++   SQ++ + +     +         Q++E+Q+      +DV     + +   N  +
Sbjct: 3067 IQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQA--GPLNIDVAPGAPQEK---NGVH 3121

Query: 466  MEKDEAE-KEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRL 524
             + D  E +E ++  ++  + L    QE+ +LR  L+E +      +   ++A E+  RL
Sbjct: 3122 RKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRL 3181


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 119/628 (18%), Positives = 259/628 (41%), Gaps = 58/628 (9%)

Query: 66  PELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMP--TMHDLVHTIN 123
           P + +    ++L +   Q  D   + +PS     S  +  +      P  T     H+  
Sbjct: 49  PMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPE 108

Query: 124 DQSQYIH-HLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDAS 182
           D+ +  H H EA     + EL    + I+++  +   LQ  L   +      E    D  
Sbjct: 109 DEQKASHQHQEA----LRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLI 164

Query: 183 GNMHNSWITTGEDS---GVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIE 239
             +H+SW   GE         T K+       +  K   A   LEL +  +T EE  E  
Sbjct: 165 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDA-LSLELYRNTITDEELKEKN 223

Query: 240 ---ESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQT 296
              + +L+ + ++ +E Q   ++LK +L+  + LL             K  Q  +   Q 
Sbjct: 224 AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA 283

Query: 297 HTN-------VHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQV------ 343
                     ++ Q  E++ ++ + +      ++      +++E    EQ +++      
Sbjct: 284 QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM 343

Query: 344 -------LQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKE 396
                  ++  EE  +EK + + + +++  E E +   LE+++  Q++ R  E+   ++E
Sbjct: 344 MWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE 403

Query: 397 ITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGE 456
             +E+E    +   + +   ++  Q EK+ +++     Q E+I  Q   RE +  +   E
Sbjct: 404 KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEE 463

Query: 457 MRYQLNKTNMEKD----------------EAEKEHREFRAKTNRDLEIKDQEIEKLRIE- 499
           M  Q  K   +++                + EK  R+     +++ +I++QE +  R E 
Sbjct: 464 MWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEE 523

Query: 500 -LDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQAL 558
            + E ++ + ++++K     E      E +GE E ++    QEK   Q+   +E + +  
Sbjct: 524 KIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQ--EQEKMRRQEEKIREQEEKIR 581

Query: 559 QAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTR 618
           + +++ +E  +KI + E    +   EQ  ++  Q   + + +E+ C   +K+++  +K R
Sbjct: 582 EQKEKIREQEEKIWEQE----EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 637

Query: 619 SEIAQLSQEKRYTYDKLGKLQRRNEELE 646
            +  ++ +++     +  K+Q   E LE
Sbjct: 638 RQEEKMWEQEVRLRQQEEKMQEHQEHLE 665


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
            [Homo sapiens]
          Length = 1354

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 150/706 (21%), Positives = 294/706 (41%), Gaps = 91/706 (12%)

Query: 62   RTAWPELQQSHAVNQLKDLLRQQAD----------KESEVSPSRRRKMSPLRSLEHEETN 111
            +T +   +Q H   QLKD + Q+            KE +   ++RR +    S   +E  
Sbjct: 430  KTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKM 489

Query: 112  MPTMHDLVHTIND-------QSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQL 164
            +     L H IN+       +++   ++E EV   K++L  +K   Q   L NE L Q L
Sbjct: 490  L-----LQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQ-L 543

Query: 165  KSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQ-- 222
            + Q +E     +T  D +  +  S     +     E+  R     N     + S  ++  
Sbjct: 544  QKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDY 603

Query: 223  ------LELEKLKLTYEEKCEIE--------ESQLKFLRNDLAEYQRTCEDLKEQLKHKE 268
                  LE E+    ++ +   +        + ++K L+++L + +   ++ ++ L H E
Sbjct: 604  YQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSE 663

Query: 269  FLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLAD 328
                    N    L  K    +  L Q   N H  T  RL  +   +  A       +  
Sbjct: 664  ----KEKNNLEIDLNYKLKSLQQRLEQ-EVNEHKVTKARLTDKHQSIEEAKSVAMCEMEK 718

Query: 329  TQQREASAYEQVK-QVLQISEEANFEKTKALIQCDQLRKELERQAERLE---KELASQQE 384
              + E  A E+ + +V+QI ++ +      L Q  Q  + L    ER+E   K L  Q E
Sbjct: 719  KLKEEREAREKAENRVVQIEKQCSMLDVD-LKQSQQKLEHLTGNKERMEDEVKNLTLQLE 777

Query: 385  KRAIEKDMMKKEITKEREYMGSKMLILSQNIAQ-----------LEAQVEKVTKEKISAI 433
            + + ++ +++ E+ K + +    +  L + + Q           LE ++ ++TK+     
Sbjct: 778  QESNKRLLLQNEL-KTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNE 836

Query: 434  NQLEEIQSQLASREMDVTKVCGEMRYQLNKTNME--KDEAEKEHREFRAKTNRDLEIKDQ 491
             Q+ E+Q QL + +   T         L KT ++  K+E E+++RE   K    ++    
Sbjct: 837  GQMRELQDQLEAEQYFST---------LYKTQVKELKEEIEEKNRENLKK----IQELQN 883

Query: 492  EIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSK 551
            E E L  +LD ++   E EQ    L  E+   LT+   ES+      RQE      + S+
Sbjct: 884  EKETLATQLDLAETKAESEQLARGLLEEQYFELTQ---ESKKAASRNRQEITDKDHTVSR 940

Query: 552  EAKAQALQAQQRE------QELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCT 605
              +A ++  +  E      +ELT+K+++ E ++   + E+   L +   F   +  E   
Sbjct: 941  LEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKA--AFEKNINTERTL 998

Query: 606  LAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQ 665
              + + ++++    +  ++ ++K  T D L K ++ N +L+ +  Q     E   Q + +
Sbjct: 999  KTQAVNKLAEIMNRKDFKIDRKKANTQD-LRKKEKENRKLQLELNQE---REKFNQMVVK 1054

Query: 666  LDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQS 711
              K       QLV+  + +N+L ++  S   ++++LR +L  +  S
Sbjct: 1055 HQKELNDMQAQLVEECAHRNELQMQLASKESDIEQLRAKLLDLSDS 1100



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 56/285 (19%), Positives = 125/285 (43%), Gaps = 48/285 (16%)

Query: 445 SREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESK 504
           S +  + K   ++  QL+     KDE E++ R    K           ++K+  ELDE  
Sbjct: 423 SLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIK-----------LDKIMKELDEEG 471

Query: 505 QHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFS------KEAKAQAL 558
                 +   +   +E + L   + E + +     +++ +++   S      ++ K  + 
Sbjct: 472 NQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQ 531

Query: 559 QAQQREQELTQKIQQMEAQHD--KTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQ---I 613
            +Q   ++L+Q  +Q+E  +D  +TE++  + L   +T ++K   +  +L ++L++   I
Sbjct: 532 NSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRI 591

Query: 614 SQKTRSEI--------AQLSQEKR---YTYDKLGKLQRRNEELEEQCVQHGRVHETMKQR 662
            + ++S+         A L  E+R   +  + +G LQ R   L+E+ V+H      +K  
Sbjct: 592 LENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEE-VKH------LKHN 644

Query: 663 LRQLDKHSQATAQQLVQLLSKQNQLLLE--------RQSLSEEVD 699
           L +++   +     L     ++N L ++        +Q L +EV+
Sbjct: 645 LEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVN 689


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 147/747 (19%), Positives = 308/747 (41%), Gaps = 97/747 (12%)

Query: 4    SPENSTLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAP----NLSFST--SVG 57
            S   +T + + GQ + + + +   +   L   LKEG  T  +DA     NL F    ++ 
Sbjct: 531  SNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGS-TDNDDATKRKVNLVFEKIQTLK 589

Query: 58   NEDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHD 117
            +  A +A    Q  ++ +++KDLL Q++    EV+  +R+    +++ ++ +     M  
Sbjct: 590  SRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRA 649

Query: 118  LVHTINDQ-----------SQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQL-- 164
             +  +  Q            Q +   E E++   EEL  +K + +    E   LQ QL  
Sbjct: 650  NLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSE 709

Query: 165  ---------KSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGK 215
                     +S+ +E+    + LL A  ++ +  I   E   +    +R  +       +
Sbjct: 710  MHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKE 769

Query: 216  AASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANT 275
              S+ +Q E++KLK  Y+                 AE Q   E ++E  K+ E L + + 
Sbjct: 770  EVSSHDQ-EMDKLKEQYD-----------------AELQALRESVEEATKNVEVLASRSN 811

Query: 276  CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREAS 335
             +          + +   ++    +  +  E+L    ++L   +  ++  + D +  EA 
Sbjct: 812  TS----------EQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAK 861

Query: 336  AYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKK 395
            A E +K+     E    +  +AL+   +  KE       LE EL + Q   +        
Sbjct: 862  AKETLKKY----EGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLS-------- 909

Query: 396  EITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCG 455
            + T+E++ +  K+   S+   QL     ++  E+      +E++Q ++A    D+ +   
Sbjct: 910  QTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMA----DIVEASR 965

Query: 456  EMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRI---ELDESKQHLEQEQQ 512
                +L     + DE ++++R   A+  R L+ K  E EK R+   ++ +  + +E+E +
Sbjct: 966  TSTLELQN---QLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELR 1022

Query: 513  KAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQ 572
                A++E L   +LL ++   L    + K  ++   S+  K    +  Q E EL ++  
Sbjct: 1023 DYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERN 1082

Query: 573  QMEAQHDKTENEQYLLLTSQNTFLTKLKE----ECCTLAKKLEQISQKTRSEIAQLSQEK 628
              +   ++    +  +   +N  L +       EC  ++  LE+ ++  +S I  L    
Sbjct: 1083 NSDLLSERISRSREQMEQLRNELLQERAARQDLECDKIS--LERQNKDLKSRIIHLEGSY 1140

Query: 629  RYTYDKLG-KLQRRNEELEEQC-----------VQHGRVHETMKQRLRQLDKHSQATAQQ 676
            R + + L  +++ R  ELE++            + + R+   +K+ + Q+D    +   Q
Sbjct: 1141 RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQ 1200

Query: 677  LVQLLSKQNQLLLERQSLSEEVDRLRT 703
              QL  +   +  + +   EE+DRL +
Sbjct: 1201 KDQLSLRLKAMKRQVEEAEEEIDRLES 1227



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 94/513 (18%), Positives = 210/513 (40%), Gaps = 62/513 (12%)

Query: 225  LEKLKLTYEEKCE--------IEESQLKFLRN---------DLAEYQRTCEDLKEQLK-- 265
            LE+L+  + EK E        +EES+ +  +N         +  ++Q    DL++QL   
Sbjct: 651  LEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEM 710

Query: 266  HKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSS 325
            H E   A  + +R  G  ++                +Q +    +E++DL+       ++
Sbjct: 711  HDELDSAKRSEDREKGALIE--------ELLQAKQDLQDLLIAKEEQEDLLRKRERELTA 762

Query: 326  LADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEK 385
            L    + E S+++Q    L+   +A  +  +  ++  +  K +E  A R      S+Q++
Sbjct: 763  LKGALKEEVSSHDQEMDKLKEQYDAELQALRESVE--EATKNVEVLASRSN---TSEQDQ 817

Query: 386  RAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISA----------INQ 435
               E  M  K + +E E +  +   L + +AQL+ Q+E +  ++  A          I Q
Sbjct: 818  AGTE--MRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQ 875

Query: 436  LEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEK 495
            LEE        E +       +  +L        +  +E ++   K   + E K+Q + +
Sbjct: 876  LEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQ-LRR 934

Query: 496  LRIELDESKQHLE---QEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKE 552
            L+ E++  + HL    ++ QK      E  R + L  E ++QL   +++         ++
Sbjct: 935  LKNEMENERWHLGKTIEKLQKEMADIVEASRTSTL--ELQNQLDEYKEKNRRELAEMQRQ 992

Query: 553  AKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQ 612
             K + L+A++      +   +M    ++  + Q            + ++E  T  + LEQ
Sbjct: 993  LKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ------------RAQDEALTKRQLLEQ 1040

Query: 613  ISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQA 672
              +    E+   S  K      + +++ +  +LE +  +     + + +R+ +  +  + 
Sbjct: 1041 TLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQ 1100

Query: 673  TAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
               +L+Q  + +  L  ++ SL  +   L++++
Sbjct: 1101 LRNELLQERAARQDLECDKISLERQNKDLKSRI 1133



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 119/591 (20%), Positives = 239/591 (40%), Gaps = 75/591 (12%)

Query: 161  QQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAG 220
            QQ+L  Q  EET ++         ++N       D+      K     +     K+ +AG
Sbjct: 543  QQELTQQTNEETAKQI--------LYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAG 594

Query: 221  EQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVG 280
                  +   +  E  ++ E + K L  ++AE QR    L+ ++K+++ +       R  
Sbjct: 595  SAQGNNQACNSTSEVKDLLEQKSK-LTIEVAELQR---QLQLEVKNQQNIKEERERMRAN 650

Query: 281  GLCLKCAQHEAVLSQTHTNVHMQTIE-RLVKERDDLMSALVSV---RSSLADTQQREASA 336
               L+   +E V   +     ++  E  L K  ++L    +     ++ + D Q + +  
Sbjct: 651  LEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEM 710

Query: 337  YEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKE 396
            ++++    +  +       + L+Q  Q  ++L    E  E  L  ++ +    K  +K+E
Sbjct: 711  HDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEE 770

Query: 397  ITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGE 456
            ++   + M          +  L   VE+ TK        +E + S+  + E D  +   E
Sbjct: 771  VSSHDQEMDKLKEQYDAELQALRESVEEATK-------NVEVLASRSNTSEQD--QAGTE 821

Query: 457  MRYQLNKTNMEKDEAEKEHREFR-AKTNRDLE-IKDQEIEKLRI---------ELDESKQ 505
            MR +L +   EK +   E  E R A+  R +E +K  E +             +L+E+  
Sbjct: 822  MRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALV 881

Query: 506  HLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQ 565
            H  +E+++A  AR     L   L  ++  L  T QE+  + +   KE   Q  Q ++ + 
Sbjct: 882  HARKEEKEAVSARR---ALENELEAAQGNLSQTTQEQKQLSEKL-KEESEQKEQLRRLKN 937

Query: 566  ELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLS 625
            E+  +   +    +K + E   ++ +  T   +L+ +       L++  +K R E+A++ 
Sbjct: 938  EMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQ-------LDEYKEKNRRELAEMQ 990

Query: 626  ---QEKRYTYDK----LGKLQRRNEELEEQCVQHGRV-------HETMKQRLRQLD---- 667
               +EK    +K      K+Q     +EE+   + R         + ++Q L+ L+    
Sbjct: 991  RQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELE 1050

Query: 668  --KHSQATAQQLV-QLLSKQNQLLLERQS-------LSEEVDRLRTQLPSM 708
               H +    +LV Q+  K +QL +E +        LSE + R R Q+  +
Sbjct: 1051 AKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQL 1101



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 92/445 (20%), Positives = 181/445 (40%), Gaps = 71/445 (15%)

Query: 74   VNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLE 133
            + QL++ L     +E E   +RR   + L + +          +L  T  +Q Q    L+
Sbjct: 873  IRQLEEALVHARKEEKEAVSARRALENELEAAQG---------NLSQTTQEQKQLSEKLK 923

Query: 134  AEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTG 193
             E +  KE+L  +KN+     +ENE        ++ ++ + +  +++AS        +T 
Sbjct: 924  EESEQ-KEQLRRLKNE-----MENERWHLGKTIEKLQKEMAD--IVEASRT------STL 969

Query: 194  EDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEY 253
            E     +  K     + A+  +     + LE EK +LT  +     + +++ +  +L +Y
Sbjct: 970  ELQNQLDEYKEKNRRELAEMQRQLKE-KTLEAEKSRLTAMKM----QDEMRLMEEELRDY 1024

Query: 254  QRTCED-------LKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIE 306
            QR  ++       L++ LK  E+ L A +  +             ++ Q    V    +E
Sbjct: 1025 QRAQDEALTKRQLLEQTLKDLEYELEAKSHLK--------DDRSRLVKQMEDKVSQLEME 1076

Query: 307  RLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRK 366
             L +ER++  S L+S R S      R     EQ++  L     A  +     I  ++  K
Sbjct: 1077 -LEEERNN--SDLLSERIS------RSREQMEQLRNELLQERAARQDLECDKISLERQNK 1127

Query: 367  ELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVE--- 423
            +L+ +   LE    S +E   ++ +    E+    E        L  +  +LE +V+   
Sbjct: 1128 DLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELV 1187

Query: 424  -KVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKT 482
             +V  E +S  +Q +++  +L +           M+ Q+ +   E D  E      + K 
Sbjct: 1188 MQVDDEHLSLTDQKDQLSLRLKA-----------MKRQVEEAEEEIDRLESS----KKKL 1232

Query: 483  NRDLEIKDQEIEKLRIELDESKQHL 507
             R+LE +    E L+ +L+  K+ L
Sbjct: 1233 QRELEEQMDMNEHLQGQLNSMKKDL 1257



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 44/193 (22%), Positives = 85/193 (44%), Gaps = 18/193 (9%)

Query: 527 LLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELT-QKIQQME--AQHDKTEN 583
           L G+ E       +    I  ++ KE       A +R+  L  +KIQ ++  A      N
Sbjct: 540 LKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGN 599

Query: 584 EQYLLLTSQNTFL----TKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQ 639
            Q    TS+   L    +KL  E   L ++L Q+  K +  I +  +  R   ++L    
Sbjct: 600 NQACNSTSEVKDLLEQKSKLTIEVAELQRQL-QLEVKNQQNIKEERERMRANLEELRS-- 656

Query: 640 RRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVD 699
           + NE++EE        + T++QRL + +   +   ++L Q+  ++ Q   E + L +++ 
Sbjct: 657 QHNEKVEE--------NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLS 708

Query: 700 RLRTQLPSMPQSD 712
            +  +L S  +S+
Sbjct: 709 EMHDELDSAKRSE 721


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 130/676 (19%), Positives = 279/676 (41%), Gaps = 61/676 (9%)

Query: 75   NQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQY-----I 129
            N  KDL++++A  E  +   R      ++ LE E  ++   +  V ++  +SQ      +
Sbjct: 526  NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL---NQTVSSLRQRSQISAEARV 582

Query: 130  HHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQL-----KSQRQEETLREQTLLDASGN 184
              +E E K   E +    +K+  +  E   ++++L     K +R EE   E   L+    
Sbjct: 583  KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE 642

Query: 185  MHNSWIT----TGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEE 240
            +    IT    T E     E        +N    K   + + L  + L+   +E  +++E
Sbjct: 643  LLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQ-LESLEKENSQLDE 701

Query: 241  SQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNV 300
              L+  RN  +    + +  + QL++KE         +   L     +    L  ++  +
Sbjct: 702  ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL 761

Query: 301  HMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQ 360
             ++  +RL K  ++    +  + S L D +    +  + +++ L+IS +   +  K    
Sbjct: 762  DIEN-QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE-LKISSKRLEQLEKENKS 819

Query: 361  CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKE------ITKEREYMGSKMLILSQN 414
             +Q   +LE+  ++LEKE    +++  I+   +++       + KE + +  ++ I  ++
Sbjct: 820  LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879

Query: 415  IAQLEAQVEKVTKEKISA----INQLEEIQSQLASREM-------DVTKVCGEM-RYQLN 462
              +L+ ++EK  KE +      I  L  ++  L S ++       D+ K+  E+ +  LN
Sbjct: 880  CVRLK-ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN 938

Query: 463  KTNMEKDEAEKEHR------EFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAAL 516
            K  +  DE   + R      +  +   + LEIK+++I  L   L+ES  + +Q +Q+   
Sbjct: 939  KERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 998

Query: 517  AREECLRLTELLGESEH-QLHLTRQEKDSIQQSFSKEAKAQALQAQQR------------ 563
             ++    L +   E    Q       +D+  +  S+E   + L+ + R            
Sbjct: 999  VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ 1058

Query: 564  --EQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEI 621
              +Q L  +++Q+E Q++  +  Q L L  Q   L +      T   KL+  +    S+ 
Sbjct: 1059 AEKQALKTQLKQLETQNNNLQ-AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1117

Query: 622  AQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLL 681
              L  +      +   L+  NE + ++      +++++ +   +L+   +  A +   L+
Sbjct: 1118 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1177

Query: 682  SKQNQLLLERQSLSEE 697
            SK   L    ++L  E
Sbjct: 1178 SKHGTLKSAHKNLEVE 1193



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 150/725 (20%), Positives = 310/725 (42%), Gaps = 94/725 (12%)

Query: 6    ENSTLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAW 65
            ENS L+E   + +R++      S+      L+  ++   ++          G E  + ++
Sbjct: 695  ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKE------QLKKGLELLKASF 748

Query: 66   PELQQSHAVNQLKDLLRQQADKESEVSPSRRRKM-SPLRSLEHEETNMPTMHDLVHTIND 124
             + ++     Q  D+  Q+  K  E S  + +++ S L+ LE E     T+   +  +  
Sbjct: 749  KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQ---TLQKNLEELKI 805

Query: 125  QSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGN 184
             S+ +  LE E K  ++E S ++   + +  EN+ L+QQ  ++ ++ TL E  +    GN
Sbjct: 806  SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ--AEIKDTTLEENNV--KIGN 861

Query: 185  MHNSWITTGEDSGVGETS---KRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEES 241
            +     T  ++ G+ + S    +    +N +  K A+    ++++ L +T  E    E+ 
Sbjct: 862  LEKENKTLSKEIGIYKESCVRLKELEKENKELVKRAT----IDIKTL-VTLREDLVSEKL 916

Query: 242  QLKFLRNDLAEYQRTCEDL---KEQLKHKE------FLLAANTCNRVGGLCL-----KCA 287
            + + + NDL +     E +   KE+L H E      + L  +         L     K A
Sbjct: 917  KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIA 976

Query: 288  QHEAVLSQTHTNVHMQTIERL---------VKERDDLMSALVSVRSSLADTQQREASAYE 338
              EA L ++ TN + Q  + L         +K+R D    + S      +  + E  + E
Sbjct: 977  ALEARLEES-TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQE 1035

Query: 339  QVKQVLQISEEA-NFEKTKALIQCDQLR-----KELERQAERLEKELAS--------QQE 384
              +++L++ +     E+  A +Q ++       K+LE Q   L+ ++ +        Q++
Sbjct: 1036 TTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1095

Query: 385  KRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLA 444
               ++    K ++  E   + S+   L    AQL  Q   +  E  S I + E+++S   
Sbjct: 1096 NTTLQTQNAKLQV--ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD 1153

Query: 445  SREMDVTKVCGEMRYQLNKTNMEK-----DEAEKEHREFRAKTNRDLEIKDQEIEKLRIE 499
            S   D  K+  E+ ++   +  E         +  H+    + +RDLE +  ++ K + +
Sbjct: 1154 SLIKDHEKL--ELLHERQASEYESLISKHGTLKSAHKNLEVE-HRDLEDRYNQLLKQKGQ 1210

Query: 500  LDESKQHLEQEQQKAALAREE----CLRLTELLGESEHQLHLTRQ---EKDSIQ------ 546
            L++ ++ L+ EQ+K  L  +          +L GE++   H   Q   E + +Q      
Sbjct: 1211 LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNL 1270

Query: 547  QSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTL 606
            +S    +K +  + +    +L ++ QQ++    K  N+  LL   +      L+EE   L
Sbjct: 1271 KSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGN----LEEENRHL 1326

Query: 607  AKKLEQISQKTRSEIAQLSQ-------EKRYTYDKLGKLQRRNEELEEQCVQHGRVHETM 659
              +++ +  + R+ + Q  +       E+R   DKL +L+R+ E+LEE+ +   + ++  
Sbjct: 1327 LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPS 1386

Query: 660  KQRLR 664
              R R
Sbjct: 1387 PPRRR 1391



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 136/637 (21%), Positives = 271/637 (42%), Gaps = 95/637 (14%)

Query: 139 CKEELSGMKNKIQVVVLENEGLQQQLKSQR----QEETLREQTL-LDASGNMHNSWITTG 193
           CK+EL  M+ +++ +  EN  L    +S R    + + LRE+ + +D   +  + +    
Sbjct: 277 CKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERL 336

Query: 194 EDSGVGETSKRPFSHDNADF------------GKAASAGEQLELEKLKLTYEEK---CEI 238
            D    +        DN               G  A + +  ELEK  L  + K    E+
Sbjct: 337 HDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEM 396

Query: 239 EESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLA-----ANTCNRVGGLCLKCAQHEA-- 291
           E    +    +L E   T E  ++Q   +   L       +  + +     K   HE   
Sbjct: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNE 456

Query: 292 VLSQTHTNVHMQTIERLVKERDDLMSALVSVRSS------LADTQQREASAYE------- 338
           + S     + M+  + L K  ++L + + SV  +      +    QR +   E       
Sbjct: 457 LTSSRLLKLEMEN-QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515

Query: 339 QVKQVLQ---------ISEEANFEKTKALIQCDQLR--KELERQAERLEKELASQQEKRA 387
           Q KQ LQ         + E+A  EKT   ++ +  R  K LE++ E L + ++S +++  
Sbjct: 516 QEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQ 575

Query: 388 IEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVT------KEKISAINQLE---- 437
           I  +   K+I KE + +   +   S  ++++E +  ++       KEK     +LE    
Sbjct: 576 ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH 635

Query: 438 --EIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTN--RDLEIKDQEI 493
             E +++L  +++   K+  E   ++     E  E E+E+R+ +   +  ++L  + + +
Sbjct: 636 HLEKENELLQKKITNLKITCE---KIEALEQENSELERENRKLKKTLDSFKNLTFQLESL 692

Query: 494 EKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSK-- 551
           EK   +LDE    L +  +    A  +  +L     E E +    ++  + ++ SF K  
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752

Query: 552 --EAKAQALQAQQREQELT-----QKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECC 604
             E   Q L  + +  + T     +KIQQ+E++    E E        N  L K  EE  
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME--------NQTLQKNLEELK 804

Query: 605 TLAKKLEQISQKTRS---EIAQLSQEKRYTYDKLGKLQRRNE----ELEEQCVQHGRVHE 657
             +K+LEQ+ ++ +S   E +QL ++K+    +  +L+++ E     LEE  V+ G + +
Sbjct: 805 ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEK 864

Query: 658 TMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSL 694
             K   +++  + ++  +  ++ L K+N+ L++R ++
Sbjct: 865 ENKTLSKEIGIYKESCVR--LKELEKENKELVKRATI 899



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 131/678 (19%), Positives = 279/678 (41%), Gaps = 100/678 (14%)

Query: 90   EVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQS--QYIHHLEAEV--------KFC 139
            ++S +     +P +SL HE   + +   L   + +QS  + +  L   V        K  
Sbjct: 435  QISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL 494

Query: 140  KEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVG 199
            K E    +   +V +LENE +Q++   Q  +   ++  L+     +  +  T  E+S   
Sbjct: 495  KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKD--LMKEKAQLEKTIETLRENS--- 549

Query: 200  ETSKRPFSHDNADFGKAASA---GEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRT 256
            E   +    +N    +  S+     Q+  E      E++ +I    +K   + L++ +  
Sbjct: 550  ERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFE 609

Query: 257  CEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHM--QTIERLVKERDD 314
               +K++L+H  +         +        +   +L +  TN+ +  + IE L +E  +
Sbjct: 610  KRQIKKELEH--YKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667

Query: 315  LMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKAL--IQCDQLRKELERQA 372
            L      ++ +L   +          K+  Q+ EE N E  + +  ++C  + K  + Q 
Sbjct: 668  LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASM-KMAQLQL 725

Query: 373  ERLEKELASQQEKRAIE--KDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKI 430
            E  E E   +Q K+ +E  K   KK    E  Y G            L+ + +++ K   
Sbjct: 726  ENKELESEKEQLKKGLELLKASFKKTERLEVSYQG------------LDIENQRLQKTLE 773

Query: 431  SAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKD 490
            ++  ++++++S+L   EM+          Q  + N+E+ +   +  E   K N+ LE + 
Sbjct: 774  NSNKKIQQLESELQDLEME---------NQTLQKNLEELKISSKRLEQLEKENKSLEQET 824

Query: 491  QEIEKLRIELDESKQHLEQE-------------------------QQKAALAREECLRLT 525
             ++EK + +L++  + L Q+                          ++  + +E C+RL 
Sbjct: 825  SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884

Query: 526  ELLGESEHQLHLTRQEKD-SIQQSFSKEAKAQALQAQQREQELTQKIQQME--------- 575
            EL  E E++  + R   D     +  ++  ++ L+ QQ   +L +   ++E         
Sbjct: 885  EL--EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL 942

Query: 576  AQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKL 635
               +++ +++Y LL S      KL+    TL K LE   +K  +  A+L +   Y     
Sbjct: 943  LHDEQSTDDRYKLLES------KLES---TLKKSLEIKEEKIAALEARLEESTNYNQQLR 993

Query: 636  GKLQ--RRNEELEEQCVQHGRVHET---MKQRLRQLDKHSQATAQQLVQLLSKQNQLLLE 690
             +L+  ++N E  +Q     R+ ++   +     + ++ SQ T ++L+++  +  ++   
Sbjct: 994  QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERN 1053

Query: 691  RQSLSEEVDRLRTQLPSM 708
              +L  E   L+TQL  +
Sbjct: 1054 NATLQAEKQALKTQLKQL 1071



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 97/425 (22%), Positives = 190/425 (44%), Gaps = 52/425 (12%)

Query: 301 HMQTIERLVKERDDLM---SALVSVRS-----SLADTQQRE------ASAYEQVKQVLQI 346
           H +TI  L +ERD L     A  S +S      +  T+ R+      A A  +++++ Q 
Sbjct: 207 HSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQE 266

Query: 347 SEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGS 406
            EE    KT+ L+ C Q  +++E + +RL++E  +     A    M + E+   RE    
Sbjct: 267 LEE----KTEQLLDCKQELEQMEIELKRLQQENMNLLSD-ARSARMYRDELDALRE---- 317

Query: 407 KMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNM 466
                +  + +LE++V +  KE++  I   +    +L      + +    +  QL  T  
Sbjct: 318 ----KAVRVDKLESEVSRY-KERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372

Query: 467 EKD---EAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLR 523
             D   E EKE+ + +AK + D+E++     K   EL E    LE  Q++   + +E L 
Sbjct: 373 RSDKLHELEKENLQLKAKLH-DMEMERDMDRKKIEELMEENMTLEMAQKQ---SMDESLH 428

Query: 524 LTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTEN 583
           L   L +      L+   + S+    ++   ++ L+ +   Q LT+ ++++    D  E 
Sbjct: 429 LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488

Query: 584 EQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKL---GKLQR 640
               +L        K+++E   L+KK+E +  +   E   L   +  + D +    +L++
Sbjct: 489 NASKIL--------KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540

Query: 641 RNEELEEQCVQHGRV----HETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSE 696
             E L E   +  ++    +E + Q +  L + SQ +A+  V+ + K+N++L   +S+ E
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKIL--HESIKE 598

Query: 697 EVDRL 701
              +L
Sbjct: 599 TSSKL 603


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 152/698 (21%), Positives = 295/698 (42%), Gaps = 127/698 (18%)

Query: 83   QQADKESEVSPSRRRKMSPLRSLEHEETNMPT-MHDLVHTINDQSQYIHHLEAEVKFCKE 141
            ++A+ E E++     K    R LE E + +   + DL  T+    +  H  E +VK   E
Sbjct: 928  ERAEDEEEINAELTAKK---RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE 984

Query: 142  ELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGET 201
            E++G+   I  +  E + LQ+            +QTL D             E+  V   
Sbjct: 985  EMAGLDETIAKLTKEKKALQE----------AHQQTLDDLQ----------AEEDKVNTL 1024

Query: 202  SKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLK 261
            +K     +        S  ++   +K+++  E      E  LK  +    + +   + L 
Sbjct: 1025 TKAKIKLEQQVDDLEGSLEQE---KKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLD 1081

Query: 262  EQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVS 321
            E+LK KEF         + GL  K    +A+  Q       + I+ L    ++L   + +
Sbjct: 1082 EKLKKKEF--------EMSGLQSKIEDEQALGMQL-----QKKIKELQARIEELEEEIEA 1128

Query: 322  VRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELAS 381
             R+S A  +++ +    +++++ +  EEA    T A I+ ++ ++E E Q  R + E A+
Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAG-GATSAQIEMNK-KREAEFQKMRRDLEEAT 1186

Query: 382  QQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQS 441
             Q + A    + KK      E +G ++     N+ +++ ++EK   E    I+ L     
Sbjct: 1187 LQHE-ATAATLRKKHADSVAE-LGEQI----DNLQRVKQKLEKEKSEMKMEIDDLASNME 1240

Query: 442  QLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKT----------NRDLEIKDQ 491
             ++  + ++ K+C  +  QL++   +++E ++   +  A+           +R L+ KD 
Sbjct: 1241 TVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDT 1300

Query: 492  EIEKL-------RIELDESKQHLEQE-QQKAALA------REECLRLTELLGE------- 530
             + +L         +++E K+ LE+E + K+ALA      R +C  L E   E       
Sbjct: 1301 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAE 1360

Query: 531  ---------SEHQLHLTRQEKDSIQQS----FSKEAKAQALQ-AQQREQELTQKIQQMEA 576
                     SE     T+ E D+IQ++     +K+  AQ LQ A++  + +  K   +E 
Sbjct: 1361 LQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEK 1420

Query: 577  QHDKTENE-QYLLLTSQNT----------------FLTKLKEECCTLAKKLEQISQKTRS 619
               + +NE + L++  + T                 L + K++C     +LE   +++RS
Sbjct: 1421 TKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRS 1480

Query: 620  ---EIAQLSQEKRYTYDKLGKLQRRNEELE-------EQCVQHG-RVH--ETMKQRLRQL 666
               E+ ++      + D+L  L+R N+ L+       EQ  + G R+H  E +K+++ Q 
Sbjct: 1481 LSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQE 1540

Query: 667  DKHSQATAQQLVQLLSKQN----QLLLERQSLSEEVDR 700
                QA  ++    L  +     ++ LE   +  EVDR
Sbjct: 1541 KSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1578



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 86/421 (20%), Positives = 191/421 (45%), Gaps = 45/421 (10%)

Query: 310  KERDDLMSALVSVRSSLADTQQREASAYE------QVKQVLQISEEANFEK-TKALIQCD 362
            KE  ++       +  LA T+ +     E      Q K  LQ+  +A  +    A  +CD
Sbjct: 851  KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCD 910

Query: 363  QLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQV 422
            QL K  + Q E   KE+     +RA +++ +  E+T ++  +  +   L ++I  LE  +
Sbjct: 911  QLIKT-KIQLEAKIKEVT----ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965

Query: 423  EKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKT 482
             KV KEK +  N+++ +  ++A  +  + K+  E +          D+ + E  +    T
Sbjct: 966  AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1025

Query: 483  NRDLEIKDQ---------EIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEH 533
               ++++ Q         + +K+R++L+ +K+ LE + +   LA+E  + +     + + 
Sbjct: 1026 KAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLK---LAQESTMDIENDKQQLDE 1082

Query: 534  QLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQN 593
            +L     E   +Q     E +A  +Q Q++ +EL  +I+++E +           + ++ 
Sbjct: 1083 KLKKKEFEMSGLQSKIEDE-QALGMQLQKKIKELQARIEELEEE-----------IEAER 1130

Query: 594  TFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHG 653
                K +++   L+++LE+IS++        S +      +  + Q+   +LEE  +QH 
Sbjct: 1131 ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1190

Query: 654  RVHETMKQRLRQLDKHSQATA---QQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQ 710
                T+++      KH+ + A   +Q+  L   + +L  E+  +  E+D L + + ++ +
Sbjct: 1191 ATAATLRK------KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSK 1244

Query: 711  S 711
            +
Sbjct: 1245 A 1245



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 156/730 (21%), Positives = 297/730 (40%), Gaps = 107/730 (14%)

Query: 59   EDARTAWPELQQSHAVNQLKDLLRQ------------QADKESEVSPSRRRKMSPLRSLE 106
            E A  A  E Q+S    +L+++  +            + +K+ E    + R+     +L+
Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188

Query: 107  HEETNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENE-------- 158
            HE T          ++ +  + I +L+   +  ++E S MK +I  +    E        
Sbjct: 1189 HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGN 1248

Query: 159  ------GLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNAD 212
                   L+ QL   + +E  +++ + D +         +GE S   +  ++        
Sbjct: 1249 LEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSR--QLDEKDTLVSQLS 1306

Query: 213  FGKAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHK----- 267
             GK A   +   +E+LK   EE+ + + +    L + L   +  C+ L+EQ + +     
Sbjct: 1307 RGKQAFTQQ---IEELKRQLEEEIKAKSA----LAHALQSSRHDCDLLREQYEEEQEAKA 1359

Query: 268  EFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLA 327
            E   A +  N          + +A+          + + + +++ ++ + A+ +  +SL 
Sbjct: 1360 ELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLE 1419

Query: 328  DTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKEL-ASQQEKR 386
             T+QR  +  E +   ++ +  A     K     D++  E +++ E    EL ASQ+E R
Sbjct: 1420 KTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESR 1479

Query: 387  AIEKDMMK-----KEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQS 441
            ++  ++ K     +E   + E +  +   L Q I+ L  Q+ +  K     I++LE+I+ 
Sbjct: 1480 SLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKR----IHELEKIKK 1535

Query: 442  QLASREMDVTKVCGE------------MRYQLN----KTNMEKDEAEKEHREFRAKTNR- 484
            Q+   + ++     E            +R QL     K+ +++  AEK+    + K N  
Sbjct: 1536 QVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHI 1595

Query: 485  ----------DLEIKDQE-----IEKLRIELDESKQHLEQEQQKAALAREECLRLTELLG 529
                      D EI+ +       +K+  +L+E +  L    + AA A         +L 
Sbjct: 1596 RIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILK 1655

Query: 530  ESEHQLHL---TRQEKDSIQQSFSKEAKAQALQAQQRE----QELTQKIQQMEAQHDKTE 582
            ++  QLHL    R ++D  +Q    E +A  LQA+  E     E T++ +++  Q     
Sbjct: 1656 DT--QLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA 1713

Query: 583  NEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGK----L 638
            +E+  LL +QNT L   K       KKLE    + + E+  + QE R   +K  K     
Sbjct: 1714 SERVQLLHTQNTSLINTK-------KKLETDISQIQGEMEDIIQEARNAEEKAKKAITDA 1766

Query: 639  QRRNEELEEQCVQHGRVH-ETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEE 697
                EEL+++  Q    H E MK+ L Q  K  Q    +  QL  K  +  +  Q L   
Sbjct: 1767 AMMAEELKKE--QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQI--QKLEAR 1822

Query: 698  VDRLRTQLPS 707
            V  L  ++ S
Sbjct: 1823 VRELEGEVES 1832



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 132/597 (22%), Positives = 244/597 (40%), Gaps = 114/597 (19%)

Query: 203  KRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDL-- 260
            K  F     +  K  +  ++LE EK+    +EK +++  Q++   + LA+ +  C+ L  
Sbjct: 857  KEEFEKTKEELAKTEAKRKELE-EKMVTLMQEKNDLQ-LQVQAEADSLADAEERCDQLIK 914

Query: 261  -KEQLKHK----------EFLLAANTCNRVGGLCLKCAQH-------EAVLSQTHTNVHM 302
             K QL+ K          E  + A    +   L  +C++        E  L++     H 
Sbjct: 915  TKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH- 973

Query: 303  QTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCD 362
               E  VK   + M+ L    + L   ++    A++Q    LQ  E+     TKA I+ +
Sbjct: 974  -ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLE 1032

Query: 363  Q--------------LRKELERQAERLEKELASQQEKRA-IEKDMMK-KEITKEREYMGS 406
            Q              +R +LER   +LE +L   QE    IE D  +  E  K++E+  S
Sbjct: 1033 QQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMS 1092

Query: 407  KMLILSQNIAQLEAQVEKVTKEKISAINQL-EEIQSQLASREMDVTKVCGEMRYQLNKTN 465
             +    ++   L  Q++K  KE  + I +L EEI+++ ASR         +   Q +  +
Sbjct: 1093 GLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASR--------AKAEKQRSDLS 1144

Query: 466  MEKDEAEKEHREFRAKTNRDLEI---KDQEIEKLRIELDESKQHLEQEQQKAALAREECL 522
             E +E  +   E    T+  +E+   ++ E +K+R +L+E+   L+ E   A L ++   
Sbjct: 1145 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT--LQHEATAATLRKKHAD 1202

Query: 523  RLTELLGESEHQLHLTRQ-----------EKDSIQQSFSKEAKA-------------QAL 558
             + E LGE    L   +Q           E D +  +    +KA             Q  
Sbjct: 1203 SVAE-LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS 1261

Query: 559  QAQQREQELTQKIQQMEAQHDK--TENEQY-LLLTSQNTFLTKLKEECCTLAKKLEQISQ 615
            + + +E+E  + I  + AQ  +  TE+ +Y   L  ++T +++L        +++E++ +
Sbjct: 1262 EIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKR 1321

Query: 616  ------KTRSEIAQLSQEKRYTYDKL-----------GKLQRRNEELEEQCVQHGRVHET 658
                  K +S +A   Q  R+  D L            +LQR   +   +  Q    +ET
Sbjct: 1322 QLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYET 1381

Query: 659  ---------------MKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDR 700
                           + QRL+  ++H +A   +   L   + +L  E + L  +V+R
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVER 1438



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 91/493 (18%), Positives = 201/493 (40%), Gaps = 81/493 (16%)

Query: 73   AVNQLKDLLRQQADKESEVSP---------SRRRKMSPLRSLEHEETNMPTMHDLVHTIN 123
            +++QL+ L R+  + + E+S           R  ++  ++    +E +     +L   + 
Sbjct: 1495 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKS-----ELQAALE 1549

Query: 124  DQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASG 183
            +    + H E ++   + EL+ +K+++   + E +    Q+K          Q+ LDA  
Sbjct: 1550 EAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEI 1609

Query: 184  NMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQL 243
               N  I            K+    D  +     +   ++  E L+     +  ++++QL
Sbjct: 1610 RSRNDAIRL----------KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQL 1659

Query: 244  KFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQ 303
                  L +  R+ EDLKEQL   E         R   L  +  +  A L QT  +  + 
Sbjct: 1660 H-----LDDALRSQEDLKEQLAMVE--------RRANLLQAEIEELRATLEQTERSRKIA 1706

Query: 304  TIERL-VKERDDLM----SALVSVRSSL-ADTQQREASAYEQVKQVLQISEEANFEKTKA 357
              E L   ER  L+    ++L++ +  L  D  Q +    + +++     E+A    T A
Sbjct: 1707 EQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDA 1766

Query: 358  LIQCDQLRKELERQA--ERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLI--LSQ 413
             +  ++L+KE +  A  ER++K L     ++ ++    + +  ++    G K  I  L  
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNL-----EQTVKDLQHRLDEAEQLALKGGKKQIQKLEA 1821

Query: 414  NIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEK 473
             + +LE +VE   K  + A+  L + + ++            E+ YQ           E+
Sbjct: 1822 RVRELEGEVESEQKRNVEAVKGLRKHERKVK-----------ELTYQ----------TEE 1860

Query: 474  EHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEH 533
            + +         L ++D  ++KL+ ++   K+  E+ ++++ +   +  R+   L E+E 
Sbjct: 1861 DRKNI-------LRLQDL-VDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEE 1912

Query: 534  QLHLTRQEKDSIQ 546
            +  +   + + ++
Sbjct: 1913 RADIAESQVNKLR 1925



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 56/225 (24%), Positives = 97/225 (43%), Gaps = 33/225 (14%)

Query: 488  IKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQ 547
            +K  E EK    + E     E E+ K  LA+ E  R      E E ++    QEK+ +Q 
Sbjct: 844  LKSAETEKEMANMKE-----EFEKTKEELAKTEAKRK-----ELEEKMVTLMQEKNDLQL 893

Query: 548  SFSKEAKAQALQAQQREQELTQKIQ---QMEAQHDKTENEQYLLLTSQNTFLT----KLK 600
                EA + A   ++ +Q +  KIQ   +++   ++ E+E+ +     N  LT    KL+
Sbjct: 894  QVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEI-----NAELTAKKRKLE 948

Query: 601  EECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMK 660
            +EC  L K ++ +       +A++ +EK  T +K+  L      L+E   +       + 
Sbjct: 949  DECSELKKDIDDL----ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK-------LT 997

Query: 661  QRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
            +  + L +  Q T   L     K N L   +  L ++VD L   L
Sbjct: 998  KEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1042



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 60/274 (21%), Positives = 112/274 (40%), Gaps = 19/274 (6%)

Query: 140  KEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNM------HNSWITTG 193
            KE+L+ ++ +  ++  E E L+  L+   +   + EQ LLDAS  +      + S I T 
Sbjct: 1672 KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK 1731

Query: 194  EDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLK--LTYEEKCEIEESQLKFLRNDLA 251
            +     ET       +  D  + A   E+   + +       E+ + E+     L     
Sbjct: 1732 KKL---ETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788

Query: 252  EYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEA-VLSQTHTNVH----MQTIE 306
              ++T +DL+ +L   E L       ++  L  +  + E  V S+   NV     ++  E
Sbjct: 1789 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHE 1848

Query: 307  RLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRK 366
            R VKE   L       R ++   Q        +VK   + +EEA  +    L +  +++ 
Sbjct: 1849 RKVKE---LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQH 1905

Query: 367  ELERQAERLEKELASQQEKRAIEKDMMKKEITKE 400
            ELE   ER +   +   + R   +++  K I++E
Sbjct: 1906 ELEEAEERADIAESQVNKLRVKSREVHTKIISEE 1939


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 149/716 (20%), Positives = 279/716 (38%), Gaps = 111/716 (15%)

Query: 22   REHASRSIHQLTCALKEGDVTIGEDAPNLS-FSTSVGNEDARTAWPELQQSHAVNQLKDL 80
            R+     + +L     EG+    E A  ++     + N     +  + + S        L
Sbjct: 1247 RKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL 1306

Query: 81   LRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVKFCK 140
              Q  D +  +    R+K+S    L+  E    +  +    + ++ +  H+LE ++    
Sbjct: 1307 ESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE---QLEEEEEAKHNLEKQIATLH 1363

Query: 141  EELSGMKNKIQ--VVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGV 198
             +++ MK K++  V  LE     +++K + Q++       L+     H   +   +    
Sbjct: 1364 AQVADMKKKMEDSVGCLETA---EEVKRKLQKD-------LEGLSQRHEEKVAAYDKL-- 1411

Query: 199  GETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCE 258
             E +K     +  D            L  L    +  C +E+ Q KF +  LAE +    
Sbjct: 1412 -EKTKTRLQQELDDL-----------LVDLDHQRQSACNLEKKQKKFDQL-LAEEKTISA 1458

Query: 259  DLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVK----ERDD 314
               E+    E   A         L L  A  EA+  +         +ERL K    E +D
Sbjct: 1459 KYAEERDRAE---AEAREKETKALSLARALEEAMEQKAE-------LERLNKQFRTEMED 1508

Query: 315  LMSALVSVRSSLADTQQREASAYEQVKQV----------LQISEEA------NFEKTKAL 358
            LMS+   V  S+ + ++ + +  +QV+++          LQ +E+A      N +  KA 
Sbjct: 1509 LMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQ 1568

Query: 359  I---------QCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKML 409
                      Q ++ +K+L RQ   +E EL  ++++R++     KK              
Sbjct: 1569 FERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKK-------------- 1614

Query: 410  ILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQL--ASREMDVTKVCGEMRYQLNKTNME 467
             L  ++  LEA ++   K +  AI QL ++Q+Q+    RE+D T+     R ++     E
Sbjct: 1615 -LEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRA---SREEILAQAKE 1670

Query: 468  KDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTEL 527
             ++  K       +   +L   ++   + + E DE    +     K ALA EE  RL   
Sbjct: 1671 NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEAR 1730

Query: 528  LGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYL 587
            + + E +L    +E+    +  +   K   LQ  Q   +L   +++  AQ  K EN +  
Sbjct: 1731 IAQLEEEL----EEEQGNTELINDRLKKANLQIDQINTDL--NLERSHAQ--KNENARQQ 1782

Query: 588  LLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEE 647
            L         KL+E   T+  K +       ++IAQL ++          L    +E + 
Sbjct: 1783 LERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQ----------LDNETKERQA 1832

Query: 648  QCVQHGRVHETMKQRLRQLD---KHSQATAQQLVQLLSKQNQLLLERQSLSEEVDR 700
             C Q  R  + +K  L Q+D   ++++    Q  +  ++  QL  + +   EE  R
Sbjct: 1833 ACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQR 1888



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 149/706 (21%), Positives = 294/706 (41%), Gaps = 97/706 (13%)

Query: 76   QLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAE 135
            QL++ L+ + +  +E    R R  +  + LE         HDL   + ++ +   HL+AE
Sbjct: 884  QLQEQLQAETELCAEAEELRARLTAKKQELEE------ICHDLEARVEEEEERCQHLQAE 937

Query: 136  VKFCKEELSGMKNKI-------QVVVLENEGLQQQLKSQRQEETL---------REQTLL 179
             K  ++ +  ++ ++       Q + LE    + +LK   +E+ +         +E+ LL
Sbjct: 938  KKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLL 997

Query: 180  DASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIE 239
            +       + +T  E     E SK      N          E+L  E+     +++ E+E
Sbjct: 998  EDRIAEFTTNLTEEE-----EKSKSLAKLKNKHEAMITDLEERLRREE-----KQRQELE 1047

Query: 240  ESQLKF------LRNDLAEYQRTCEDLKEQLKHKEFLLAANTCN------RVGGLCLKCA 287
            +++ K       L + +AE Q    +LK QL  KE  L A          +      K  
Sbjct: 1048 KTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIR 1107

Query: 288  QHEAVLSQTHTNVHMQTIER--LVKERDDLMSALVSVRSSLADT------QQREASAYEQ 339
            + E+ +S+   ++  +   R    K++ DL   L ++++ L DT      QQ   S  EQ
Sbjct: 1108 ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ 1167

Query: 340  VKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITK 399
               +L+ + E   +  +A IQ  ++R++  +  E L ++L   +  +A   +  K+ +  
Sbjct: 1168 EVNILKKTLEEEAKTHEAQIQ--EMRQKHSQAVEELAEQLEQTKRVKA-NLEKAKQTLEN 1224

Query: 400  EREYMGSKMLILSQNIAQLEAQVEKVT---KEKISAINQLEEIQSQLASREMDVTKVCGE 456
            ER  + +++ +L Q     E + +KV    +E     N+ E ++++LA +   VTK+  E
Sbjct: 1225 ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADK---VTKLQVE 1281

Query: 457  MRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKD--QEIEKLRIELDESKQHLEQEQQKA 514
            +       +    ++ K  ++F A  ++  + ++  QE  + ++ L    + +E E+   
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSF 1341

Query: 515  ALAREECLRLTELLGESEHQLH-----LTRQEKDSIQQSFSKEAKAQALQAQQREQELTQ 569
                EE       L +    LH     + ++ +DS+    + E   + LQ     + L+Q
Sbjct: 1342 REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDL--EGLSQ 1399

Query: 570  KIQQMEAQHDKTENEQYLLLTSQNTFLTKL---KEECCTLAKKLEQ----------ISQK 616
            + ++  A +DK E  +  L    +  L  L   ++  C L KK ++          IS K
Sbjct: 1400 RHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAK 1459

Query: 617  TRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLR------------ 664
               E  +   E R    K   L R  EE  EQ  +  R+++  +  +             
Sbjct: 1460 YAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKS 1519

Query: 665  --QLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSM 708
              +L+K  +A  QQ+ ++ ++  +L  E Q+  +   RL   L +M
Sbjct: 1520 VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565



 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 109/537 (20%), Positives = 239/537 (44%), Gaps = 40/537 (7%)

Query: 215  KAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAAN 274
            +A    ++ ELE++    E + E EE + + L+ +  + Q+  ++L+EQL+ +E      
Sbjct: 903  RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL 962

Query: 275  TCNRVGGLC-LKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRS----SLADT 329
               +V     LK  + E ++ +   N  +   ++L+++R    +  ++       SLA  
Sbjct: 963  QLEKVTTEAKLKKLEEEQIILEDQ-NCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021

Query: 330  QQREASAYEQVKQVLQISEEAN--FEKTKALIQCDQLR-----KELERQAERLEKELASQ 382
            + +  +    +++ L+  E+     EKT+  ++ D         EL+ Q   L+ +LA +
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK 1081

Query: 383  QEK------RAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQL 436
            +E+      R  E+   K    K+   + S++  L +++    A   K  K+K     +L
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL 1141

Query: 437  EEIQSQLASREMDVTKVCGEMRYQLNK-TNMEKDEAEKEHREFRAKTNRDLEIKDQEIEK 495
            E ++++L    +D T    E+R +  +  N+ K   E+E +   A+     +   Q +E+
Sbjct: 1142 EALKTELEDT-LDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEE 1200

Query: 496  LRIELDESKQ---HLEQEQQKAALAREECLRLTELL----GESEHQLHLTRQEKDSIQQS 548
            L  +L+++K+   +LE+ +Q     R E     ++L    G+SEH+      +   +Q  
Sbjct: 1201 LAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVK 1260

Query: 549  FSK------EAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLL---LTSQNTFLTKL 599
            F++      E   +  + Q     +T  + Q +++  K   +   L   L      L + 
Sbjct: 1261 FNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE 1320

Query: 600  KEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYD---KLGKLQRRNEELEEQCVQHGRVH 656
              +  +L+ KL+Q+  +  S   QL +E+   ++   ++  L  +  +++++        
Sbjct: 1321 NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCL 1380

Query: 657  ETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQSDC 713
            ET ++  R+L K  +  +Q+  + ++  ++L   +  L +E+D L   L    QS C
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSAC 1437



 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 136/689 (19%), Positives = 296/689 (42%), Gaps = 114/689 (16%)

Query: 76   QLKDLLRQQADKESEVSPSRRR-------KMSPLRSLEHEETNMPTMHDLVHTINDQSQY 128
            Q+ +L  Q A KE E+  +  R       K   L+ +   E+ +    +L   +  +   
Sbjct: 1070 QIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQIS---ELQEDLESERAS 1126

Query: 129  IHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNS 188
             +  E + +   EEL  +K +++   L++   QQ+L+S+R++E    +  L+     H +
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDT-LDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185

Query: 189  WITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQ--LKFL 246
             I                        K + A E+L  E+L+ T   K  +E+++  L+  
Sbjct: 1186 QIQEMRQ-------------------KHSQAVEELA-EQLEQTKRVKANLEKAKQTLENE 1225

Query: 247  RNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQ-----THTNVH 301
            R +LA   +     K   +HK   + A    ++  L +K  + E V ++     T   V 
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEA----QLQELQVKFNEGERVRTELADKVTKLQVE 1281

Query: 302  MQTIERLVKERDDLMSALV----SVRSSLADTQQ-------REASAYEQVKQV------- 343
            +  +  L+ + D   S L     ++ S L DTQ+       ++ S   ++KQV       
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSF 1341

Query: 344  ---LQISEEA--NFEKTKALIQ---------------CDQLRKELERQAERLEKELASQQ 383
               L+  EEA  N EK  A +                C +  +E++R+ ++  + L+ + 
Sbjct: 1342 REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRH 1401

Query: 384  EKRAIEKDMMKKEITKEREYMGSKMLILS---QNIAQLEAQVEK----VTKEKISAINQL 436
            E++    D ++K  T+ ++ +   ++ L    Q+   LE + +K    + +EK  +    
Sbjct: 1402 EEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYA 1461

Query: 437  EEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKL 496
            EE     A      TK     R  L +   +K E E+ +++FR +    +  KD ++ K 
Sbjct: 1462 EERDRAEAEAREKETKALSLAR-ALEEAMEQKAELERLNKQFRTEMEDLMSSKD-DVGKS 1519

Query: 497  RIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQ 556
              EL++SK+ LEQ+ ++     EE     +   +++ +L +  Q   +++  F ++ + +
Sbjct: 1520 VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ---AMKAQFERDLQGR 1576

Query: 557  ALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQK 616
              Q+++++++L +++++MEA+ +    ++ + + ++               KKLE   + 
Sbjct: 1577 DEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAAR---------------KKLEMDLKD 1621

Query: 617  TRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQ 676
              + I   ++ +     +L KLQ + ++   +        E +  + ++ +K  ++   +
Sbjct: 1622 LEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAE 1681

Query: 677  LVQLLSK-------QNQLLLERQSLSEEV 698
            ++QL  +       + Q   ER  L++E+
Sbjct: 1682 MIQLQEELAAAERAKRQAQQERDELADEI 1710



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 81/386 (20%), Positives = 171/386 (44%), Gaps = 51/386 (13%)

Query: 352  FEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLIL 411
            F K K L+Q    R+E E  A+  E+EL   +EK+   ++ + +  T + + M  K+ + 
Sbjct: 831  FTKVKPLLQVS--RQEEEMMAK--EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQ 886

Query: 412  SQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEA 471
             Q  A+ E   E             EE++++L +++ ++ ++C ++  ++ +        
Sbjct: 887  EQLQAETELCAEA------------EELRARLTAKKQELEEICHDLEARVEEEEERCQHL 934

Query: 472  EKEHREFR---AKTNRDLEIKDQEIEKLRIE---LDESKQHLEQEQ-----QKAALAREE 520
            + E ++ +    +    LE ++   +KL++E    +   + LE+EQ     Q   LA+E+
Sbjct: 935  QAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEK 994

Query: 521  CLRLTELLGESEHQLHLTRQEKDSIQQSFSK-----EAKAQALQAQQREQELTQKIQQME 575
             L    +   +E   +LT +E+ S  +S +K     EA    L+ + R +E  ++ Q++E
Sbjct: 995  KLLEDRI---AEFTTNLTEEEEKS--KSLAKLKNKHEAMITDLEERLRREE--KQRQELE 1047

Query: 576  AQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKL 635
                K E +   L         ++ E    LAKK E++ Q   + + + + +K     K+
Sbjct: 1048 KTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEEL-QAALARVEEEAAQKNMALKKI 1106

Query: 636  GKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLL-----------SKQ 684
             +L+ +  EL+E            +++ R L +  +A   +L   L            ++
Sbjct: 1107 RELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE 1166

Query: 685  NQLLLERQSLSEEVDRLRTQLPSMPQ 710
             ++ + +++L EE      Q+  M Q
Sbjct: 1167 QEVNILKKTLEEEAKTHEAQIQEMRQ 1192



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 75/359 (20%), Positives = 157/359 (43%), Gaps = 66/359 (18%)

Query: 78   KDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTIN----DQSQYIHHLE 133
            K L+RQ  + E+E+   R+++   + + +  E ++  +   + + N    +  + +  L+
Sbjct: 1585 KQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ 1644

Query: 134  AEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTG 193
            A++K C  EL   +   + ++ + +  +++LKS   E                   I   
Sbjct: 1645 AQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAE------------------MIQLQ 1686

Query: 194  EDSGVGETSKRPFSHDNADFGK--AASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLA 251
            E+    E +KR    +  +     A S+G      K  L  EEK  +E +++  L  +L 
Sbjct: 1687 EELAAAERAKRQAQQERDELADEIANSSG------KGALALEEKRRLE-ARIAQLEEELE 1739

Query: 252  EYQRTCEDLKEQLKHKEFLL-AANT---CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIER 307
            E Q   E + ++LK     +   NT     R      + A+ +         V +Q +E 
Sbjct: 1740 EEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEG 1799

Query: 308  LVKERDDLMSALVSVRSSLA--------DTQQREASAYEQVKQ--------VLQISEEA- 350
             VK +    +++ ++ + +A        +T++R+A A +QV++        +LQ+ +E  
Sbjct: 1800 TVKSK--YKASITALEAKIAQLEEQLDNETKERQA-ACKQVRRTEKKLKDVLLQVDDERR 1856

Query: 351  NFEK-----TKALIQCDQLRKELERQAERLEKELASQQE-KRAIE-----KDMMKKEIT 398
            N E+      KA  +  QL+++LE   E  ++  AS+++ +R +E      D M +E++
Sbjct: 1857 NAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVS 1915



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 36/162 (22%), Positives = 77/162 (47%), Gaps = 17/162 (10%)

Query: 558 LQAQQREQELTQKIQQMEAQHDK---TENEQYLLLTSQNTFLTKLKEECCTLAKKLE--- 611
           LQ  ++E+E+  K +++    +K    EN     LT   T  ++L  E   L ++L+   
Sbjct: 838 LQVSRQEEEMMAKEEELVKVREKQLAAENR----LTEMETLQSQLMAEKLQLQEQLQAET 893

Query: 612 QISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQ 671
           ++  +     A+L+ +K+   +    L+ R EE EE+C       + M+Q +++L+    
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELE---- 949

Query: 672 ATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQSDC 713
              +QL +  S + +L LE+ +   ++ +L  +   +   +C
Sbjct: 950 ---EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNC 988


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 121/647 (18%), Positives = 270/647 (41%), Gaps = 71/647 (10%)

Query: 66  PELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMP--TMHDLVHTIN 123
           P + +    ++L +   Q  D   + +PS     S  +  +      P  T     H+  
Sbjct: 110 PMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPE 169

Query: 124 DQSQYIH-HLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDAS 182
           D+ +  H H EA     + EL    + I+++  +   LQ  L   +      E    D  
Sbjct: 170 DEQKASHQHQEA----LRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLI 225

Query: 183 GNMHNSWITTGEDS---GVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIE 239
             +H+SW   GE         T K+       +  K   A   LEL +  +T EE  E  
Sbjct: 226 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDA-LSLELYRNTITDEELKEKN 284

Query: 240 ---ESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQT 296
              + +L+ + ++ +E Q   ++LK +L+  + LL             K  Q  +   Q 
Sbjct: 285 AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA 344

Query: 297 HTN-------VHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQV------ 343
                     ++ Q  E++ ++ + +      ++      +++E    EQ +++      
Sbjct: 345 QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM 404

Query: 344 -------LQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKE 396
                  ++  EE  +EK + + + +++  E E +   LE+++  Q++ R  E+   ++E
Sbjct: 405 MWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE 464

Query: 397 ITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGE 456
             +E+E    +   + +   ++  Q EK+ +++     Q E+I  Q   RE +  +   E
Sbjct: 465 KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEE 524

Query: 457 MRYQLNKTNMEKD---EAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQK 513
           M  Q  K   +++   + EK H +            +++I K   ++   ++ +  +++K
Sbjct: 525 MWRQEEKIREQEEIWRQKEKIHEQ------------EEKIRKQEEKMWRQEEKMHDQEEK 572

Query: 514 AALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQ 573
                E+  R  E + E E ++   ++EK   Q+  ++E   Q  +  ++E+++ ++ ++
Sbjct: 573 IREQEEKVWRQEEKIREQEEKIR-EQEEKIREQEEMTQE---QEEKMGEQEEKMCEQEEK 628

Query: 574 MEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYD 633
           M+ Q +K   ++            K++E+     KK+ +  +K R +   + +++   ++
Sbjct: 629 MQEQEEKMRRQE-----------EKIREQ----EKKIREQEEKIREQEEMMQEQEEKMWE 673

Query: 634 KLGKLQRRNEELEEQCVQHGRVHETM---KQRLRQLDKHSQATAQQL 677
           +  K+  + E+++EQ  +  R  E M   + RLRQ ++  Q   + L
Sbjct: 674 QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 720



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 90/420 (21%), Positives = 200/420 (47%), Gaps = 42/420 (10%)

Query: 305 IERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEA----NFEKTKALIQ 360
           IE L KERD L  +L   R+++ D + +E +A  Q K  L  SE++    N ++ K  ++
Sbjct: 256 IEELTKERDAL--SLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 313

Query: 361 CDQL---RKELERQAERLEKELASQQEK--RAIEKDMMKKEITKEREYMGSKMLILSQNI 415
             +L   +++L+ +A+ L KEL S   K    +E++ +   + +++E    KM    + I
Sbjct: 314 RAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE---EKMWRQEEKI 370

Query: 416 AQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEH 475
            + E ++++  ++      ++ E + ++  +E  + +   +MR Q  +   EK+E  +  
Sbjct: 371 QEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ-EEMMWEKEEKMRRQ 429

Query: 476 REF---RAKTNRDLEIKDQEIEKLRIELDESKQHLE--------QEQQKAALAREECLRL 524
            E    + +  R+LE K  E EK+R E +E +Q  E        QEQ+     +EE +R 
Sbjct: 430 EEMMWEKEEKIRELEEKMHEQEKIR-EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 488

Query: 525 TELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENE 584
            E     + +    ++EK   Q+   +E K Q  +   R++E  ++ +++  Q +K    
Sbjct: 489 QEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEK---- 544

Query: 585 QYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEE 644
               +  Q   + K +E+     +K+    +K R +     +EK +  ++  K++ + E+
Sbjct: 545 ----IHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQ-----EEKVWRQEE--KIREQEEK 593

Query: 645 LEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQ 704
           + EQ  +     E  +++  ++ +  +   +Q  ++  ++ ++  + + + E+  ++R Q
Sbjct: 594 IREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQ 653


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 129/599 (21%), Positives = 259/599 (43%), Gaps = 93/599 (15%)

Query: 124  DQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASG 183
            +Q + +H    E +  +E L G++ K    + E   L++ L+S   E  L  Q   + + 
Sbjct: 509  EQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTA 568

Query: 184  NMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQL 243
             +  +  +  E S    T K   +   A   K ++  E L L+K+ L  +     EE+Q 
Sbjct: 569  ALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQS 628

Query: 244  KFLRNDLAEYQRTC--EDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVH 301
               R + AE  R     DL E  K +E L   N                     TH    
Sbjct: 629  VCSRMEAAEQARNALQVDLAEAEKRREALWEKN---------------------THLEAQ 667

Query: 302  MQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQC 361
            +Q  E           A   +++ L D Q+ +    E++++ L    E+  ++  A  Q 
Sbjct: 668  LQKAE----------EAGAELQADLRDIQEEK----EEIQKKL---SESRHQQEAATTQL 710

Query: 362  DQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQ 421
            +QL +E +RQ E L + +   QEK A+ ++    E+         ++  + ++   L  Q
Sbjct: 711  EQLHQEAKRQEEVLARAV---QEKEALVREKAALEV---------RLQAVERDRQDLAEQ 758

Query: 422  VEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAK 481
            ++ ++  K    + L E Q Q  +  ++VTK  G++  Q+      K             
Sbjct: 759  LQGLSSAKELLESSLFEAQQQ--NSVIEVTK--GQLEVQIQTVTQAK------------- 801

Query: 482  TNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAA--LAREECLRLTEL-LGESEHQLHLT 538
                 E+   E+  L++ELD  +   EQE+  AA  LA+ E    T L   ++ H+  + 
Sbjct: 802  -----EVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVN 856

Query: 539  R-QEKDSIQQSFSKEAKAQALQAQQREQ-ELTQKIQQMEAQHDKTENEQYLLLTSQNTFL 596
            + +EK   ++S+ ++  A+AL++ +RE+ EL  ++++ + + +  + ++    T   + L
Sbjct: 857  QLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESAL 916

Query: 597  TKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVH 656
             +++ E       L +   +T+ E+A  SQ+          L+R  ++++ Q ++     
Sbjct: 917  CQMQLETEKERVSLLETLLQTQKELADASQQ----------LERLRQDMKVQKLKEQETT 966

Query: 657  ETMKQRLRQLDKHSQATAQQ----LVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQS 711
              ++ +L++  +  +  A+Q    L  L  + + LL ++  L ++V+ L++QL +   S
Sbjct: 967  GILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDS 1025



 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 149/656 (22%), Positives = 268/656 (40%), Gaps = 122/656 (18%)

Query: 67   ELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQS 126
            E +QS ++++L  L         E    R+ +     +L   E ++  +    +T+  + 
Sbjct: 532  EAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEV 591

Query: 127  QYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMH 186
                   A+++    +LS +    + + L+  GL QQL  Q +EE     + ++A+    
Sbjct: 592  -------ADLRAAAVKLSALN---EALALDKVGLNQQLL-QLEEENQSVCSRMEAAEQAR 640

Query: 187  NSW-ITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKF 245
            N+  +   E     E      +H  A   KA  AG +L+ + L+   EEK EI++ +L  
Sbjct: 641  NALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQAD-LRDIQEEKEEIQK-KLSE 698

Query: 246  LRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTI 305
             R+         E L ++ K +E +LA     +             V  +    V +Q +
Sbjct: 699  SRHQQEAATTQLEQLHQEAKRQEEVLARAVQEK----------EALVREKAALEVRLQAV 748

Query: 306  ER----LVKERDDLMSALVSVRSSLADTQQREA-------------SAYEQVKQVLQ--- 345
            ER    L ++   L SA   + SSL + QQ+ +                 Q K+V+Q   
Sbjct: 749  ERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEV 808

Query: 346  --ISEEANFEKTKA----------LIQCDQLRKE-LERQAERLEKELASQQEKRAIEKDM 392
              +  E + E+++A          L Q +Q  K  LE+Q    EKE+   +EK   E+  
Sbjct: 809  RCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSW 868

Query: 393  MKKEITK-----EREYMGSKMLILSQNIA----------------------QLEAQVEKV 425
             ++E+ K     ERE M  +M +  Q                         QLE + E+V
Sbjct: 869  HQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERV 928

Query: 426  T---------KEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHR 476
            +         KE   A  QLE ++  +  +++   +  G ++ QL +   E  EA ++HR
Sbjct: 929  SLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHR 988

Query: 477  EFRA----------KTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLR--- 523
            +  A          +   DL+ + ++++   +  D+S++ +EQE Q+     +E  R   
Sbjct: 989  DDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQK 1048

Query: 524  --------LTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQM- 574
                    LT  L E E +L L  QE DSI+Q      +    +AQ  ++EL+ +++ + 
Sbjct: 1049 ELEREKASLTLSLMEKEQRL-LVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLR 1107

Query: 575  ----EAQHDKTENEQYLLLTSQNTFLT--KLKEECCTLAKKLEQISQKTRSEIAQL 624
                E + D    E  LL   + + +T  +L+        K  Q+  + RS  +QL
Sbjct: 1108 QEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQL 1163



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 157/739 (21%), Positives = 302/739 (40%), Gaps = 93/739 (12%)

Query: 8    STLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAWPE 67
            S LE +  + Q   +  A   +  L  AL++   ++ E  P LS     G + A + W  
Sbjct: 1161 SQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSG----GGDSAPSVWGL 1216

Query: 68   LQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQ 127
                +    L                    K  PL +    E     +H L   +    Q
Sbjct: 1217 EPDQNGARSLF-------------------KRGPLLTALSAEAVASALHKLHQDLWKTQQ 1257

Query: 128  YIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETL---REQTLLDASGN 184
                L  +V+  +E L+  + +   V  E + LQ+QL   ++E++    ++ +L      
Sbjct: 1258 TRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELME 1317

Query: 185  MHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLK 244
            +H +  +        E  +R  +    +  +AA      ++E L+    E    + S   
Sbjct: 1318 LHETMASLQSRLRRAEL-QRMEAQGERELLQAAKENLTAQVEHLQAAVVE-ARAQASAAG 1375

Query: 245  FLRNDLAEYQRTC----EDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNV 300
             L  DL   +       E+++ + +  + L          G  L+  ++ A+L+QT    
Sbjct: 1376 ILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ--ENLALLTQTLAER 1433

Query: 301  HMQT------IERLVKERD------DLMSALVSVRSSLADTQQREASAYEQVKQVLQISE 348
              +       I+ L K+R+      +L+S  +  R+   D QQ +    E+ + VL+   
Sbjct: 1434 EEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLP 1493

Query: 349  EANFEKTKAL-IQCDQLRK----------ELERQAERLEKELASQQEKRAIEKDMMKKEI 397
             A  E+ + L +Q +Q+R+           LE Q   LEK+    + +R   +D+ K+ +
Sbjct: 1494 MAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLV 1553

Query: 398  TKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEM 457
            T E        L L +N  ++E Q +K+ KE      Q E  +  L    +D+ +   E+
Sbjct: 1554 TLE-----CLALELEENHHKMECQ-QKLIKE---LEGQRETQRVALTHLTLDLEERSQEL 1604

Query: 458  RYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQ--EIEKLRIELDESKQHLEQEQQKAA 515
            + Q ++ +  +  +    RE +    RD E+K Q  +IE+L+ + +   Q LE+  Q+  
Sbjct: 1605 QAQSSQIHDLESHSTVLARELQ---ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELM 1661

Query: 516  LAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQME 575
            L +E   R+  L  +   Q  +  ++ + I+ S  +  +    Q Q  ++   +     +
Sbjct: 1662 LQKE---RIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSK 1718

Query: 576  AQHDKTENEQYLL------LTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKR 629
            AQ    E+ + +L      +  Q   + +L+E    L ++L+ + +K       LSQ ++
Sbjct: 1719 AQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQ 1778

Query: 630  YTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQ---QLVQLLSKQNQ 686
                ++  LQ++ +E  EQ    G + E   Q   QLD+  +A AQ   +L  L  +Q Q
Sbjct: 1779 ----EIVVLQQQLQEAREQ----GELKEQSLQS--QLDEAQRALAQRDQELEALQQEQQQ 1828

Query: 687  LLLERQSLSEEVDRLRTQL 705
               + + + E+ D L+  L
Sbjct: 1829 AQGQEERVKEKADALQGAL 1847



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 145/699 (20%), Positives = 292/699 (41%), Gaps = 90/699 (12%)

Query: 59   EDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLE--HEETNMPTMH 116
            + A  A  ELQ       L+D+  ++ + + ++S SR ++ +    LE  H+E       
Sbjct: 669  QKAEEAGAELQAD-----LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKR---- 719

Query: 117  DLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQ 176
                    Q + +     E +    E + ++ ++Q V  + + L +QL+     + L E 
Sbjct: 720  --------QEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLES 771

Query: 177  TLLDASGNMHNSWITTGE------------DSGVGETSKRPFSHDN----ADFGKAASAG 220
            +L +A        +T G+            +   GE        D     A+  + A+A 
Sbjct: 772  SLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAAR 831

Query: 221  EQLELEKL-KLTYEEKCEIEESQLKFLRN----DLAEYQRTCEDLKEQLKHKEFLLAANT 275
            +  + E+  K   E++    E ++  LR     + + +Q+      E L+ ++  L    
Sbjct: 832  QLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRL 891

Query: 276  CNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREAS 335
              +   +    AQ E   +Q  + +    +E   KER  L+  L+  +  LAD  Q+   
Sbjct: 892  KEQQTEMEAIQAQREEERTQAESALCQMQLET-EKERVSLLETLLQTQKELADASQQ--- 947

Query: 336  AYEQVKQVLQISEEANFEKTKAL-IQCDQLRKELERQAERLEKELAS-QQEKRAIEKDMM 393
              E+++Q +++ +    E T  L  Q  + ++EL+  A +   +LA+ Q+E  ++ +D M
Sbjct: 948  -LERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006

Query: 394  KKEITKEREYMGSKMLILSQNIAQLEAQ--VEKVTKEKISAINQLEEIQSQLASREMDVT 451
              ++ K+ E + S++      +AQ ++Q  VE+  +EK+    +   IQ +L   +  +T
Sbjct: 1007 --DLQKQVEDLKSQL------VAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLT 1058

Query: 452  KVCGEM--------------RYQLNKTNMEKDEAEKEHREFRAKTNR-DLEIKDQEIEKL 496
                E               + +L+    +  EA+ E +E  A+      E+K++E + L
Sbjct: 1059 LSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFL 1118

Query: 497  RIE---LDESK-QHLEQEQQKAALAREEC--LRLTELLGESEHQLHLTRQEKDSIQQSFS 550
              E   L+E +  H+ ++Q +A+L  +E    +L   L  +E QL     E+    Q+ +
Sbjct: 1119 AQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQA 1178

Query: 551  KEAKAQALQA-QQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKK 609
            +   A    A QQ    + +   ++    D   +  + L   QN   +  K      A  
Sbjct: 1179 QAQLASLYSALQQALGSVCESRPELSGGGDSAPSV-WGLEPDQNGARSLFKRGPLLTALS 1237

Query: 610  LEQISQ---KTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQL 666
             E ++    K   ++ +  Q +    D++ KL+ R  + E    +  +VH  ++   RQL
Sbjct: 1238 AEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTE---AEKSQVHTELQDLQRQL 1294

Query: 667  DKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
             ++ +  +    +   KQN L  E   L E +  L+++L
Sbjct: 1295 SQNQEEKS----KWEGKQNSLESELMELHETMASLQSRL 1329



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 168/770 (21%), Positives = 301/770 (39%), Gaps = 111/770 (14%)

Query: 10   LEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAWPELQ 69
            L+ +  Q +R L + A  +   LT  ++     + E     S +  +  ED RTA   L+
Sbjct: 1334 LQRMEAQGERELLQAAKEN---LTAQVEHLQAAVVEARAQAS-AAGILEEDLRTARSALK 1389

Query: 70   QSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYI 129
              +   + +    Q   ++ E+  ++ + +    +L  +   +    + V T+  Q Q +
Sbjct: 1390 LKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQ--TLAEREEEVETLRGQIQEL 1447

Query: 130  HHLEAEVKFCKEELS-GMKNKIQVVVLENEGLQQQLKSQRQEETL------REQTLLDAS 182
                   K   E LS  +K + Q V L+ E +Q+  K +   E L      REQ L    
Sbjct: 1448 EKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKL---- 1503

Query: 183  GNMHNSWITTGEDSGVGETSKRPFSHDNADFGKA-----ASAGEQLELEKLKLTYE-EKC 236
              +    I   E     ET +    H   +  K      +  G+  +L+K  +T E    
Sbjct: 1504 -TVQREQIRELEKDR--ETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLAL 1560

Query: 237  EIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQT 296
            E+EE+  K     +   Q+  ++L+ Q + +   L   T +    L  +  + +A  SQ 
Sbjct: 1561 ELEENHHK-----MECQQKLIKELEGQRETQRVALTHLTLD----LEERSQELQAQSSQI 1611

Query: 297  HT-NVHMQTIERLVKERD-------DLMSALVSVRSSLADTQQREASAYEQVKQVLQISE 348
            H    H   + R ++ERD       + +  L   +  L    +R        K+ +Q+ E
Sbjct: 1612 HDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLE 1671

Query: 349  EANFEKTKALIQ-CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSK 407
            +    +TK L +  +Q++  L  +   L  +    QE+    K   K +    R  +   
Sbjct: 1672 DQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQ----RGSLEHM 1727

Query: 408  MLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNME 467
             LIL     ++E Q E         I++L+E++ QL  +   + +  GE    L++   E
Sbjct: 1728 KLILRDKEKEVECQQEH--------IHELQELKDQLEQQLQGLHRKVGETSLLLSQREQE 1779

Query: 468  KDEAEKEHREFRAK---TNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRL 524
                +++ +E R +     + L+ +  E ++   + D+  + L+QEQQ+A    E     
Sbjct: 1780 IVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEK 1839

Query: 525  TELLGESEHQLHLTRQEKDSIQQSFSKEA------------KAQALQ-------AQQREQ 565
             + L  +  Q H+T +E+    Q   ++A            + QAL+       A+ REQ
Sbjct: 1840 ADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQ 1899

Query: 566  E--LTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTL-AKKLEQISQKTRSEIA 622
            E  L    QQ   Q  + E E   L  S       LKE    L A + E  S + + E A
Sbjct: 1900 EKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAA 1959

Query: 623  QLSQEKRYTYDKLGK----LQRRNEELEEQ--------------------CVQHGRVHE- 657
            +   E     + LGK    LQ + + L EQ                    C  H R  E 
Sbjct: 1960 RARAEA--LQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEE 2017

Query: 658  ---TMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQ 704
                 +  ++  D   Q   QQL Q L+++++ L  +Q   + +++   Q
Sbjct: 2018 ALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQ 2067



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 148/672 (22%), Positives = 267/672 (39%), Gaps = 107/672 (15%)

Query: 78   KDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVK 137
            + L++++A++    S ++R       SLEH +     + D    +  Q ++IH L+    
Sbjct: 1703 RQLMQERAEEGKGPSKAQRG------SLEHMKL---ILRDKEKEVECQQEHIHELQELKD 1753

Query: 138  FCKEELSGMKNKIQVVVL-------ENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWI 190
              +++L G+  K+    L       E   LQQQL+  R++  L+EQ+L         +  
Sbjct: 1754 QLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALA 1813

Query: 191  TTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEK---CEIEESQLKFLR 247
               ++    +  ++          + A A  Q  LE+  +T +E+    +  + Q + L 
Sbjct: 1814 QRDQELEALQQEQQQAQGQEERVKEKADA-LQGALEQAHMTLKERHGELQDHKEQARRLE 1872

Query: 248  NDLAEYQRTCEDLKEQL--------KHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTN 299
             +LA   R  + L+E L        + ++ LLA          C + AQ   V ++   +
Sbjct: 1873 EELAVEGRRVQALEEVLGDLRAESREQEKALLALQQ------QCAEQAQEHEVETRALQD 1926

Query: 300  VHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALI 359
              +Q  + ++KERD  + AL +   S    ++   +  E +++ L  +  A   K + L+
Sbjct: 1927 SWLQA-QAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLL 1985

Query: 360  QCDQLRKELERQAERLEKEL-ASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQL 418
            +  +L + LE     L+  L A Q   R +E+                           L
Sbjct: 1986 EQAELSRSLEASTATLQASLDACQAHSRQLEE--------------------------AL 2019

Query: 419  EAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNM-EKDEAEK-EHR 476
              Q  ++  + +     ++++Q  LA R+        E+R+Q  +  + EK  A++ +  
Sbjct: 2020 RIQEGEIQDQDLRYQEDVQQLQQALAQRDE-------ELRHQQEREQLLEKSLAQRVQEN 2072

Query: 477  EFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLT-ELLGESEHQL 535
              + K N   E +++EI  L   + E +  L Q++Q+    RE   R   E L  S    
Sbjct: 2073 MIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTS 2132

Query: 536  HLTRQ--EKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQN 593
             +  Q  + DS++    +E   + LQA  R+ E  ++I+  E   D       L L    
Sbjct: 2133 PMEEQSLKLDSLEPRLQREL--ERLQAALRQTE-AREIEWREKAQDLA-----LSLAQTK 2184

Query: 594  TFLTKLKEECCTL-AKKLEQISQKTRS----EIAQLSQEKRYTYDKLGKLQRRNEELEEQ 648
              ++ L+E    L A  LE+ S++ R     E+ + + EK   +              EQ
Sbjct: 2185 ASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQ 2244

Query: 649  CVQHGRVHETM---------KQRLRQLDKHSQATAQQL-----------VQLLSKQNQLL 688
             VQ G V             KQ  RQ  +H Q    +L           VQL S   Q+ 
Sbjct: 2245 GVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE 2304

Query: 689  LERQSLSEEVDR 700
             ER+ L  E  R
Sbjct: 2305 RERRKLKREAMR 2316



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 82/402 (20%), Positives = 168/402 (41%), Gaps = 37/402 (9%)

Query: 326 LADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEK 385
           L + QQR  S  E   Q+    E+A+          ++L  +  R  + L ++ +  Q +
Sbjct: 103 LEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQME 162

Query: 386 RAIEKDMMKKE-----------ITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAIN 434
           +   K  +K E           +T  R ++  K     +++ +L+A+  +++   ++   
Sbjct: 163 QEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSAT-DRDLMELKAEHVRLSGSLLTCCL 221

Query: 435 QLE---EIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQ 491
           +L    + +    S  MD  +    +        +EK+  E+     + K+  DLE  + 
Sbjct: 222 RLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAE- 280

Query: 492 EIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSK 551
               L+  + E    L Q Q++     E+  ++ + L E+   L     E    + S S+
Sbjct: 281 ----LQDRVTELSALLTQSQKQ----NEDYEKMIKALRETVEILETNHTELMEHEASLSR 332

Query: 552 EAKAQALQAQQREQELTQKIQQME---AQHDKTENEQYLLLTSQNTFLTKLKEECCTLAK 608
            A+ + L  QQ  +++TQ + +     AQ    EN   L  +  + F  +  ++  TL +
Sbjct: 333 NAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVR 392

Query: 609 KLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDK 668
               +  + R  +  L Q+     + +  LQ+++++ EE+        + ++QRL++L  
Sbjct: 393 S---VLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEE-------GKALRQRLQKLTG 442

Query: 669 HSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQ 710
                A Q V L  + + L  ER+ L +  + LR QL  + Q
Sbjct: 443 ERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQ 484



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 94/469 (20%), Positives = 194/469 (41%), Gaps = 58/469 (12%)

Query: 156  ENEGLQQQLKSQRQEETL---REQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHD--- 209
            E E L+ + +S R +E     R + L +A G  H +    G++  + E ++   S +   
Sbjct: 1941 ELEALRAESQSSRHQEEAARARAEALQEALGKAHAA--LQGKEQHLLEQAELSRSLEAST 1998

Query: 210  ---NADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKH 266
                A      +   QLE E L++   ++ EI++  L++ + D+ + Q+      E+L+H
Sbjct: 1999 ATLQASLDACQAHSRQLE-EALRI---QEGEIQDQDLRY-QEDVQQLQQALAQRDEELRH 2053

Query: 267  ---KEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVR 323
               +E LL  +   RV    ++  Q+   L Q      ++ + + V+E    ++      
Sbjct: 2054 QQEREQLLEKSLAQRVQENMIQEKQN---LGQEREEEEIRGLHQSVRELQLTLAQKEQEI 2110

Query: 324  SSLADTQQRE-ASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQ 382
              L +TQQR    A     +   + E++        ++ D L   L+R+ ERL+  L  Q
Sbjct: 2111 LELRETQQRNNLEALPHSHKTSPMEEQS--------LKLDSLEPRLQRELERLQAAL-RQ 2161

Query: 383  QEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQ 442
             E R IE     +++        + +  L +    L+A V +   E+    ++LE  +  
Sbjct: 2162 TEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRA 2221

Query: 443  LASREMDVTKVC--------GEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIE 494
            L    +              GE   QL + +  + E   +  E ++   R LE   Q + 
Sbjct: 2222 LEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQR-LEHLQQAVA 2280

Query: 495  KLRIELDESKQH-------LEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQ 547
            +L I+    ++H       LEQ +++    + E +R  +        L +++    S  Q
Sbjct: 2281 RLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQ-----AGSLEISKATASSPTQ 2335

Query: 548  SFSKEAKAQALQAQQREQELTQKIQQMEAQ--HDKTENEQYLLLTSQNT 594
               ++ + Q     +   EL +++  ++AQ   ++ + + Y+  ++Q +
Sbjct: 2336 ---QDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTS 2381



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 74/374 (19%), Positives = 151/374 (40%), Gaps = 73/374 (19%)

Query: 326 LADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEK 385
           LA TQ+ E  A+E+ ++++Q+  + + EK            EL+ +   L   L   Q++
Sbjct: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKA-----------ELQDRVTELSALLTQSQKQ 298

Query: 386 RAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLAS 445
               + M+K                L + +  LE    ++ + + S     +E +  L  
Sbjct: 299 NEDYEKMIKA---------------LRETVEILETNHTELMEHEASLSRNAQEEKLSLQQ 343

Query: 446 REMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQ 505
              D+T+V  E    + + +  ++  E +   F   +  D +  D+ +  +R  L   +Q
Sbjct: 344 VIKDITQVMVEEGDNIAQGSGHENSLELDSSIF---SQFDYQDADKALTLVRSVLTRRRQ 400

Query: 506 HLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQ 565
            ++  +Q+ A  +E               ++L +Q+ D     + +E KA          
Sbjct: 401 AVQDLRQQLAGCQEA--------------VNLLQQQHDQ----WEEEGKA---------- 432

Query: 566 ELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLS 625
            L Q++Q++  + D    +              L+ E  +L+K+ E + QK R E   L 
Sbjct: 433 -LRQRLQKLTGERDTLAGQT-----------VDLQGEVDSLSKERELL-QKAREE---LR 476

Query: 626 QEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQN 685
           Q+      +  +L+R N EL+ Q        E  ++ L    +  +   + L+ L +KQ+
Sbjct: 477 QQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQS 536

Query: 686 QLLLERQSLSEEVD 699
           + L E  +L E ++
Sbjct: 537 ESLSELITLREALE 550


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 126/696 (18%), Positives = 291/696 (41%), Gaps = 70/696 (10%)

Query: 66  PELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMP--TMHDLVHTIN 123
           P + +    ++L +   Q  D   + +PS     S  +  +      P  T     H+  
Sbjct: 49  PMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPE 108

Query: 124 DQSQYIH-HLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDAS 182
           D+ +  H H EA     + EL    + I+++  +   LQ  L   +      E    D  
Sbjct: 109 DEQKASHQHQEA----LRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLI 164

Query: 183 GNMHNSWITTGEDS---GVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIE 239
             +H+SW   GE         T K+       +  K   A   LEL +  +T EE  E  
Sbjct: 165 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDA-LSLELYRNTITDEELKEKN 223

Query: 240 ---ESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQT 296
              + +L+ + ++ +E Q   ++LK +L+  + LL             K  Q  +   Q 
Sbjct: 224 AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA 283

Query: 297 HTN-------VHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQV------ 343
                     ++ Q  E++ ++ + +      ++      +++E    EQ +++      
Sbjct: 284 QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM 343

Query: 344 ---------------------LQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQ 382
                                ++  EE  +EK + + + +++  E E +   LE+++  Q
Sbjct: 344 MWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 403

Query: 383 QEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQ 442
           ++ R  E+   ++E  +E+E    +   + +   ++  Q EK+ +++     Q E+I  Q
Sbjct: 404 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ 463

Query: 443 LASREMDVTKVCGEMRYQLNKTNMEKD---EAEKEHREFRAKTNRDLEIKDQEIEKLRIE 499
              RE +  +   EM  Q  K + +++   + EK H +      ++ ++  QE EK+R +
Sbjct: 464 EKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQE-EKIREQ 522

Query: 500 LDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQ 559
            ++ +     EQ++    +EE +R  E +   E ++H    E++ I +   ++ +   + 
Sbjct: 523 EEKIR-----EQEEKMWRQEEKIREQEEMWREEEKMH----EQEKIWEEEKRQEQEDKMW 573

Query: 560 AQQ---REQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQK 616
            Q+   REQE  +K+ + E +  + E ++      Q   + K +E+     +K+++  +K
Sbjct: 574 RQEEKIREQE--EKVWRQEEKIREQEEKRQ----EQEEKMWKQEEKIREQEEKIQEQEEK 627

Query: 617 TRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQ 676
            R +  ++ +++  T ++  K+  + E++ EQ  +     ETM ++  ++ +  +   +Q
Sbjct: 628 IREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQ 687

Query: 677 LVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQSD 712
             ++  ++  +  + + + E+ +++  Q   M + +
Sbjct: 688 EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 723


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 129/677 (19%), Positives = 279/677 (41%), Gaps = 62/677 (9%)

Query: 75   NQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQY-----I 129
            N  KDL++++A  E  +   R      ++ LE E  ++   +  V ++  +SQ      +
Sbjct: 526  NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL---NQTVSSLRQRSQISAEARV 582

Query: 130  HHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQL-----KSQRQEETLREQTLLDASGN 184
              +E E K   E +    +K+  +  E   ++++L     K +R EE   E   L+    
Sbjct: 583  KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE 642

Query: 185  MHNSWIT----TGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEE 240
            +    IT    T E     E        +N    K   + + L  + L+   +E  +++E
Sbjct: 643  LLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQ-LESLEKENSQLDE 701

Query: 241  SQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNV 300
              L+  RN  +    + +  + QL++KE         +   L     +    L  ++  +
Sbjct: 702  ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL 761

Query: 301  HMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQ 360
             ++  +RL K  ++    +  + S L D +    +  + +++ L+IS +   +  K    
Sbjct: 762  DIEN-QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE-LKISSKRLEQLEKENKS 819

Query: 361  CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKE------ITKEREYMGSKMLILSQN 414
             +Q   +LE+  ++LEKE    +++  I+   +++       + KE + +  ++ I  ++
Sbjct: 820  LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879

Query: 415  IAQLEAQVEKVTKEKISA----INQLEEIQSQLASREM-------DVTKVCGEM-RYQLN 462
              +L+ ++EK  KE +      I  L  ++  L S ++       D+ K+  E+ +  LN
Sbjct: 880  CVRLK-ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN 938

Query: 463  KTNMEKDEAEKEHREFR-------AKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAA 515
            K  +  DE   +   ++       +   + LEIK+++I  L   L+ES  + +Q +Q+  
Sbjct: 939  KERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELK 998

Query: 516  LAREECLRLTELLGESEH-QLHLTRQEKDSIQQSFSKEAKAQALQAQQR----------- 563
              ++    L +   E    Q       +D+  +  S+E   + L+ + R           
Sbjct: 999  TVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATL 1058

Query: 564  ---EQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSE 620
               +Q L  +++Q+E Q++  +  Q L L  Q   L +      T   KL+  +    S+
Sbjct: 1059 QAEKQALKTQLKQLETQNNNLQ-AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117

Query: 621  IAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQL 680
               L  +      +   L+  NE + ++      +++++ +   +L+   +  A +   L
Sbjct: 1118 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1177

Query: 681  LSKQNQLLLERQSLSEE 697
            +SK   L    ++L  E
Sbjct: 1178 ISKHGTLKSAHKNLEVE 1194



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 150/726 (20%), Positives = 310/726 (42%), Gaps = 95/726 (13%)

Query: 6    ENSTLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAW 65
            ENS L+E   + +R++      S+      L+  ++   ++          G E  + ++
Sbjct: 695  ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKE------QLKKGLELLKASF 748

Query: 66   PELQQSHAVNQLKDLLRQQADKESEVSPSRRRKM-SPLRSLEHEETNMPTMHDLVHTIND 124
             + ++     Q  D+  Q+  K  E S  + +++ S L+ LE E     T+   +  +  
Sbjct: 749  KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQ---TLQKNLEELKI 805

Query: 125  QSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGN 184
             S+ +  LE E K  ++E S ++   + +  EN+ L+QQ  ++ ++ TL E  +    GN
Sbjct: 806  SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ--AEIKDTTLEENNV--KIGN 861

Query: 185  MHNSWITTGEDSGVGETS---KRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEES 241
            +     T  ++ G+ + S    +    +N +  K A+    ++++ L +T  E    E+ 
Sbjct: 862  LEKENKTLSKEIGIYKESCVRLKELEKENKELVKRAT----IDIKTL-VTLREDLVSEKL 916

Query: 242  QLKFLRNDLAEYQRTCEDL---KEQLKHKE-------FLLAANTCNRVGGLCL-----KC 286
            + + + NDL +     E +   KE+L H E       + L  +         L     K 
Sbjct: 917  KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKI 976

Query: 287  AQHEAVLSQTHTNVHMQTIERL---------VKERDDLMSALVSVRSSLADTQQREASAY 337
            A  EA L ++ TN + Q  + L         +K+R D    + S      +  + E  + 
Sbjct: 977  AALEARLEES-TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQ 1035

Query: 338  EQVKQVLQISEEA-NFEKTKALIQCDQLR-----KELERQAERLEKELAS--------QQ 383
            E  +++L++ +     E+  A +Q ++       K+LE Q   L+ ++ +        Q+
Sbjct: 1036 ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQE 1095

Query: 384  EKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQL 443
            +   ++    K ++  E   + S+   L    AQL  Q   +  E  S I + E+++S  
Sbjct: 1096 QNTTLQTQNAKLQV--ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLY 1153

Query: 444  ASREMDVTKVCGEMRYQLNKTNMEK-----DEAEKEHREFRAKTNRDLEIKDQEIEKLRI 498
             S   D  K+  E+ ++   +  E         +  H+    + +RDLE +  ++ K + 
Sbjct: 1154 DSLIKDHEKL--ELLHERQASEYESLISKHGTLKSAHKNLEVE-HRDLEDRYNQLLKQKG 1210

Query: 499  ELDESKQHLEQEQQKAALAREE----CLRLTELLGESEHQLHLTRQ---EKDSIQ----- 546
            +L++ ++ L+ EQ+K  L  +          +L GE++   H   Q   E + +Q     
Sbjct: 1211 QLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKN 1270

Query: 547  -QSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCT 605
             +S    +K +  + +    +L ++ QQ++    K  N+  LL   +      L+EE   
Sbjct: 1271 LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGN----LEEENRH 1326

Query: 606  LAKKLEQISQKTRSEIAQLSQ-------EKRYTYDKLGKLQRRNEELEEQCVQHGRVHET 658
            L  +++ +  + R+ + Q  +       E+R   DKL +L+R+ E+LEE+ +   + ++ 
Sbjct: 1327 LLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDP 1386

Query: 659  MKQRLR 664
               R R
Sbjct: 1387 SPPRRR 1392



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 136/637 (21%), Positives = 271/637 (42%), Gaps = 95/637 (14%)

Query: 139 CKEELSGMKNKIQVVVLENEGLQQQLKSQR----QEETLREQTL-LDASGNMHNSWITTG 193
           CK+EL  M+ +++ +  EN  L    +S R    + + LRE+ + +D   +  + +    
Sbjct: 277 CKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERL 336

Query: 194 EDSGVGETSKRPFSHDNADF------------GKAASAGEQLELEKLKLTYEEK---CEI 238
            D    +        DN               G  A + +  ELEK  L  + K    E+
Sbjct: 337 HDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEM 396

Query: 239 EESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLA-----ANTCNRVGGLCLKCAQHEA-- 291
           E    +    +L E   T E  ++Q   +   L       +  + +     K   HE   
Sbjct: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNE 456

Query: 292 VLSQTHTNVHMQTIERLVKERDDLMSALVSVRSS------LADTQQREASAYE------- 338
           + S     + M+  + L K  ++L + + SV  +      +    QR +   E       
Sbjct: 457 LTSSRLLKLEMEN-QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515

Query: 339 QVKQVLQ---------ISEEANFEKTKALIQCDQLR--KELERQAERLEKELASQQEKRA 387
           Q KQ LQ         + E+A  EKT   ++ +  R  K LE++ E L + ++S +++  
Sbjct: 516 QEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQ 575

Query: 388 IEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVT------KEKISAINQLE---- 437
           I  +   K+I KE + +   +   S  ++++E +  ++       KEK     +LE    
Sbjct: 576 ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH 635

Query: 438 --EIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTN--RDLEIKDQEI 493
             E +++L  +++   K+  E   ++     E  E E+E+R+ +   +  ++L  + + +
Sbjct: 636 HLEKENELLQKKITNLKITCE---KIEALEQENSELERENRKLKKTLDSFKNLTFQLESL 692

Query: 494 EKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSK-- 551
           EK   +LDE    L +  +    A  +  +L     E E +    ++  + ++ SF K  
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752

Query: 552 --EAKAQALQAQQREQELT-----QKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECC 604
             E   Q L  + +  + T     +KIQQ+E++    E E        N  L K  EE  
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME--------NQTLQKNLEELK 804

Query: 605 TLAKKLEQISQKTRS---EIAQLSQEKRYTYDKLGKLQRRNE----ELEEQCVQHGRVHE 657
             +K+LEQ+ ++ +S   E +QL ++K+    +  +L+++ E     LEE  V+ G + +
Sbjct: 805 ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEK 864

Query: 658 TMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSL 694
             K   +++  + ++  +  ++ L K+N+ L++R ++
Sbjct: 865 ENKTLSKEIGIYKESCVR--LKELEKENKELVKRATI 899



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 134/679 (19%), Positives = 280/679 (41%), Gaps = 101/679 (14%)

Query: 90   EVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQS--QYIHHLEAEV--------KFC 139
            ++S +     +P +SL HE   + +   L   + +QS  + +  L   V        K  
Sbjct: 435  QISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL 494

Query: 140  KEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVG 199
            K E    +   +V +LENE +Q++   Q  +   ++  L+     +  +  T  E+S   
Sbjct: 495  KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKD--LMKEKAQLEKTIETLRENS--- 549

Query: 200  ETSKRPFSHDNADFGKAASA---GEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRT 256
            E   +    +N    +  S+     Q+  E      E++ +I    +K   + L++ +  
Sbjct: 550  ERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFE 609

Query: 257  CEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHM--QTIERLVKERDD 314
               +K++L+H  +         +        +   +L +  TN+ +  + IE L +E  +
Sbjct: 610  KRQIKKELEH--YKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667

Query: 315  LMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKAL--IQCDQLRKELERQA 372
            L      ++ +L   +          K+  Q+ EE N E  + +  ++C  + K  + Q 
Sbjct: 668  LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASM-KMAQLQL 725

Query: 373  ERLEKELASQQEKRAIE--KDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKI 430
            E  E E   +Q K+ +E  K   KK    E  Y G            L+ + +++ K   
Sbjct: 726  ENKELESEKEQLKKGLELLKASFKKTERLEVSYQG------------LDIENQRLQKTLE 773

Query: 431  SAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKD 490
            ++  ++++++S+L   EM+          Q  + N+E+ +   +  E   K N+ LE + 
Sbjct: 774  NSNKKIQQLESELQDLEME---------NQTLQKNLEELKISSKRLEQLEKENKSLEQET 824

Query: 491  QEIEKLRIELDESKQHLEQE-------------------------QQKAALAREECLRLT 525
             ++EK + +L++  + L Q+                          ++  + +E C+RL 
Sbjct: 825  SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884

Query: 526  ELLGESEHQLHLTRQEKD-SIQQSFSKEAKAQALQAQQREQELTQKIQQME--------A 576
            EL  E E++  + R   D     +  ++  ++ L+ QQ   +L +   ++E         
Sbjct: 885  EL--EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL 942

Query: 577  QHDK--TENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDK 634
             HD+  T++ +Y LL S      KL+    TL K LE   +K  +  A+L +   Y    
Sbjct: 943  LHDEQSTDDSRYKLLES------KLES---TLKKSLEIKEEKIAALEARLEESTNYNQQL 993

Query: 635  LGKLQ--RRNEELEEQCVQHGRVHET---MKQRLRQLDKHSQATAQQLVQLLSKQNQLLL 689
              +L+  ++N E  +Q     R+ ++   +     + ++ SQ T ++L+++  +  ++  
Sbjct: 994  RQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVER 1053

Query: 690  ERQSLSEEVDRLRTQLPSM 708
               +L  E   L+TQL  +
Sbjct: 1054 NNATLQAEKQALKTQLKQL 1072



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 97/425 (22%), Positives = 190/425 (44%), Gaps = 52/425 (12%)

Query: 301 HMQTIERLVKERDDLM---SALVSVRS-----SLADTQQRE------ASAYEQVKQVLQI 346
           H +TI  L +ERD L     A  S +S      +  T+ R+      A A  +++++ Q 
Sbjct: 207 HSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQE 266

Query: 347 SEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGS 406
            EE    KT+ L+ C Q  +++E + +RL++E  +     A    M + E+   RE    
Sbjct: 267 LEE----KTEQLLDCKQELEQMEIELKRLQQENMNLLSD-ARSARMYRDELDALRE---- 317

Query: 407 KMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNM 466
                +  + +LE++V +  KE++  I   +    +L      + +    +  QL  T  
Sbjct: 318 ----KAVRVDKLESEVSRY-KERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372

Query: 467 EKD---EAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLR 523
             D   E EKE+ + +AK + D+E++     K   EL E    LE  Q++   + +E L 
Sbjct: 373 RSDKLHELEKENLQLKAKLH-DMEMERDMDRKKIEELMEENMTLEMAQKQ---SMDESLH 428

Query: 524 LTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTEN 583
           L   L +      L+   + S+    ++   ++ L+ +   Q LT+ ++++    D  E 
Sbjct: 429 LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488

Query: 584 EQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKL---GKLQR 640
               +L        K+++E   L+KK+E +  +   E   L   +  + D +    +L++
Sbjct: 489 NASKIL--------KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540

Query: 641 RNEELEEQCVQHGRV----HETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSE 696
             E L E   +  ++    +E + Q +  L + SQ +A+  V+ + K+N++L   +S+ E
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKIL--HESIKE 598

Query: 697 EVDRL 701
              +L
Sbjct: 599 TSSKL 603


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 137/644 (21%), Positives = 266/644 (41%), Gaps = 83/644 (12%)

Query: 85   ADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEELS 144
            A K +E+      K   +RSLE   TN+ T H+ +    ++++ IH          E+  
Sbjct: 717  AAKNAELEQELMEKNEKIRSLE---TNINTEHEKICLAFEKAKKIH---------LEQHK 764

Query: 145  GMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSKR 204
             M+ +I+ +  + E   QQ K Q +  ++ +Q ++    ++ +      E  G  E  K 
Sbjct: 765  EMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKG--EMKKE 822

Query: 205  PFSHDNADFGKAASAGEQLELEKLKLTY-EEKCEIEESQLKFLRNDLAEYQRTCEDLKEQ 263
                D A      +   Q+  E +K+   +   EI + +L    N L   +   E  ++Q
Sbjct: 823  NMKKDEA----LKALQNQVSEETIKVRQLDSALEICKEELVLHLNQL---EGNKEKFEKQ 875

Query: 264  LKHKEFLLAANTCNRVGGLCLKCAQHEAVL---SQTHTNVHMQTIERLVKERDDLMSALV 320
            LK K   +              C Q E  +   S   T+     ++  ++++  ++    
Sbjct: 876  LKKKSEEVY-------------CLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQET 922

Query: 321  SVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQ-CDQLRKELERQAERLEKEL 379
                 L DTQ +      +++Q LQ   E++ EK + + + C+    E + + +++  EL
Sbjct: 923  IRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVI-EL 981

Query: 380  ASQQEKRAIEKDMMKKEITK-EREYMG------SKMLILSQNIAQLEAQVEKVTKEKISA 432
                 +  IE D  K+E++K E+E M       +K + LSQ +  +  Q +   ++K +A
Sbjct: 982  TGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQ-LDMILDQTKTELEKKTNA 1040

Query: 433  INQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFR---AKTNRDLEIK 489
            + +LE++Q    +   +  +    +  +L   + E     ++ +E R    K    LE K
Sbjct: 1041 VKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEK 1100

Query: 490  DQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSF 549
               I+ L  EL E K  +E ++Q       E L + + L E   +L     +   +  + 
Sbjct: 1101 YTTIKDLTAELRECKMEIEDKKQ-------ELLEMDQALKERNWELKQRAAQVTHLDMTI 1153

Query: 550  SKEAKAQALQAQQREQELTQKIQQMEAQHDKTE---NEQYLLLTSQNTFLTKLKEECCTL 606
                       ++   E+ QKI ++E   +K+E    E    + S N  L   KE+    
Sbjct: 1154 -----------REHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQL--- 1199

Query: 607  AKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQL 666
             ++ E I  +   EI+QL +E   T  ++ +++   +E E+      +    + Q LR  
Sbjct: 1200 -REKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLT 1258

Query: 667  DKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQ 710
             +  Q +  +L +   +Q Q          E++RL ++L  M Q
Sbjct: 1259 REQVQNSHTELAEARHQQVQA-------QREIERLSSELEDMKQ 1295



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 127/685 (18%), Positives = 283/685 (41%), Gaps = 77/685 (11%)

Query: 67   ELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHD-LVHTINDQ 125
            E Q++ A+   ++L +     + +V+    +  +    LE   TN    +  L       
Sbjct: 353  ERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLY 412

Query: 126  SQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNM 185
               +  L+ +++  KEE +  K K++++ ++N  +  QL   RQ     E  L +    +
Sbjct: 413  KSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEIL 472

Query: 186  HNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKF 245
             + +    E+  +                + A+  E+L+L + ++   E   +E   L+ 
Sbjct: 473  RDKFSLMNENRELKV--------------RVAAQNERLDLCQQEI---ESSRVELRSLEK 515

Query: 246  LRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLC-----------LKCAQHEAVLS 294
            + + L   +R     K  L   +    +N  +R  G C           +K A  EA + 
Sbjct: 516  IISQLP-LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQ 574

Query: 295  QTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAY---EQVKQVLQISEEAN 351
            + H N+    + + +   +D      S + S  +T+  +   +   E VK   Q +    
Sbjct: 575  KLHANLTANQLSQSLITCNDSQE---SSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQ 631

Query: 352  FEKTKALIQC--DQLRKEL---ERQAERLEKELASQQEK-RAIEKDMMKKEITKEREYMG 405
            +EK +  +    ++LR +L   E +   L+  +A +  + + I++++++K     +  + 
Sbjct: 632  YEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSK--LE 689

Query: 406  SKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTN 465
            S+M      +  LE Q+E+      S   +  E++ +L  +   +  +   +  +  K  
Sbjct: 690  SEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKIC 749

Query: 466  MEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLT 525
            +  ++A+K H E   +  + +E  + ++EK   +  E ++ +   QQ     +     L 
Sbjct: 750  LAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLD 809

Query: 526  ELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQRE-------QELTQKIQQMEAQH 578
             LL ES+ ++     +KD   ++   +   + ++ +Q +       +EL   + Q+E   
Sbjct: 810  RLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNK 869

Query: 579  DKTE-------NEQYLL---LTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEK 628
            +K E        E Y L   L  +N  L +  E+   L   L+Q  Q  + E  + + E 
Sbjct: 870  EKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIR-NGEL 928

Query: 629  RYTYDKLGK-LQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATA-------QQLVQL 680
              T  KL K + +  +EL++Q        E+  ++LR++++  ++ A       Q++++L
Sbjct: 929  EDTQTKLEKQVSKLEQELQKQ-------RESSAEKLRKMEEKCESAAHEADLKRQKVIEL 981

Query: 681  LSKQNQLLLERQSLSEEVDRLRTQL 705
                 Q+ +E     EE+ ++  ++
Sbjct: 982  TGTARQVKIEMDQYKEELSKMEKEI 1006



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 118/641 (18%), Positives = 265/641 (41%), Gaps = 78/641 (12%)

Query: 75   NQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEA 134
            + L+ L R   + + E+     +K   L++L+++             +++++  +  L++
Sbjct: 803  HHLESLDRLLTESKGEMKKENMKKDEALKALQNQ-------------VSEETIKVRQLDS 849

Query: 135  EVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGE 194
             ++ CKEEL    N+++      E  ++QLK + +E    ++ L   + ++  +      
Sbjct: 850  ALEICKEELVLHLNQLEG---NKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVI 906

Query: 195  DSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQ 254
                 +  ++    +    G+      +LE +  KL  E + + E S  K     L + +
Sbjct: 907  LQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEK-----LRKME 961

Query: 255  RTCEDLKEQ--LKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKER 312
              CE    +  LK ++ +    T  +V    ++  Q++  LS+       + I  L ++ 
Sbjct: 962  EKCESAAHEADLKRQKVIELTGTARQVK---IEMDQYKEELSKME-----KEIMHLKRDG 1013

Query: 313  DDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQA 372
            ++    L  +   L  T+         VK++ ++      E T+AL + + L  EL+   
Sbjct: 1014 ENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAH 1073

Query: 373  ERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISA 432
              L+  L   QE R +   + K +++ E +Y   K L  +  + + + ++E   +E +  
Sbjct: 1074 GELKSTLRQLQELRDV---LQKAQLSLEEKYTTIKDL--TAELRECKMEIEDKKQELLEM 1128

Query: 433  INQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQE 492
               L+E   +L  R   VT +                  +   RE R +  + +   +  
Sbjct: 1129 DQALKERNWELKQRAAQVTHL------------------DMTIREHRGEMEQKIIKLEGT 1170

Query: 493  IEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKE 552
            +EK  +EL E  + +E    K   A+E+      ++ ++E ++   ++E +  QQ     
Sbjct: 1171 LEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQ----- 1225

Query: 553  AKAQALQAQQREQELTQKIQQMEA----QHDKTENEQYLLLTSQNTFLTKLKEECCTLAK 608
             + + +++  +EQE     Q  EA    Q  +   EQ   + + +T L + + +     +
Sbjct: 1226 -RMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQ---VQNSHTELAEARHQQVQAQR 1281

Query: 609  KLEQISQKTRSEIAQLSQEK----RYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLR 664
            ++E++S +   ++ QLS+EK     +  ++LG  + R   LE       R+   +K+   
Sbjct: 1282 EIERLSSEL-EDMKQLSKEKDAHGNHLAEELGASKVREAHLE------ARMQAEIKKLSA 1334

Query: 665  QLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQL 705
            +++   +A   +++       +  +   S    V +L  QL
Sbjct: 1335 EVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQL 1375



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 123/625 (19%), Positives = 240/625 (38%), Gaps = 95/625 (15%)

Query: 175 EQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLK----- 229
           E  L + +   H   IT      +GE        +N+D+    S  E+L L+        
Sbjct: 134 ESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHPGL 193

Query: 230 ---LTYEEKCEIEESQLKFLR-------NDLAEYQRTCEDLKEQLKHKEFLLAANTC--N 277
                YE  C+I  S   F +       +  A   +  + L+E+L     L   N C   
Sbjct: 194 LNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNK---LRQQNACLVT 250

Query: 278 RVGGLCLKCAQHEAVLSQTHTNVHM-QTIERLVKERDDLMSALVSVRS--SLADTQQREA 334
           +   L  K       L+Q+   V M ++ ++       L   ++++ +  S  D   REA
Sbjct: 251 QNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREA 310

Query: 335 SAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQ------AERLEKELASQQEKRAI 388
               +  Q + I +E + +++K   +C +L+ +L  Q      AER   E     E+ + 
Sbjct: 311 ENKLEQSQKMVIEKEQSLQESKE--ECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSK 368

Query: 389 EKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEK-------------VTKEKISAINQ 435
                KK++ ++ E + ++  IL +N+   E + ++             + KEK+  + +
Sbjct: 369 AFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKE 428

Query: 436 ---------------LEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAE--KEHREF 478
                            E+ +QL      + K+  E+    NK  + +D+     E+RE 
Sbjct: 429 ENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELE---NKDEILRDKFSLMNENREL 485

Query: 479 R---AKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAAL-----------------AR 518
           +   A  N  L++  QEIE  R+EL   ++ + Q   K  L                   
Sbjct: 486 KVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKE 545

Query: 519 EECLRLTE----LLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQM 574
           + C+   E    ++ E   +L +   E   +  + +    +Q+L      QE + K+  +
Sbjct: 546 DRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQE-SSKLSSL 604

Query: 575 EAQHDKTENEQY---LLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYT 631
           E +  K    Q    +   +Q+T   + ++E   L   +E++  K     A+ S  K   
Sbjct: 605 ETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNM 664

Query: 632 YDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLV---QLLSKQNQLL 688
             +  + Q   EEL E+     ++   M ++  QL    +   +++V    + +K  +L 
Sbjct: 665 AHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELE 724

Query: 689 LERQSLSEEVDRLRTQLPSMPQSDC 713
            E    +E++  L T + +  +  C
Sbjct: 725 QELMEKNEKIRSLETNINTEHEKIC 749



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 99/511 (19%), Positives = 217/511 (42%), Gaps = 87/511 (17%)

Query: 81   LRQQADKESEVSPSRRRKMSP-LRSLEHE-ETNMPTMHDLVHTINDQSQYIHHLEAEVKF 138
            L Q+  K+ E S  + RKM     S  HE +     + +L  T          ++ E+  
Sbjct: 942  LEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQ-------VKIEMDQ 994

Query: 139  CKEELSGMKNKIQVVVLENEG----------LQQQLKSQRQEETLREQTLLDASGNMHNS 188
             KEELS M+ +I  +  + E           +  Q K++ +++T   + L     +    
Sbjct: 995  YKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETE 1054

Query: 189  WITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLE-----LEKLKLTYEEKCEIEESQL 243
                 +   V ET  +     NA  G+  S   QL+     L+K +L+ EEK     + +
Sbjct: 1055 LTEALQKREVLETELQ-----NAH-GELKSTLRQLQELRDVLQKAQLSLEEKY----TTI 1104

Query: 244  KFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQ 303
            K L  +L E +   ED K++L   +  L      R   L  + AQ       TH ++ ++
Sbjct: 1105 KDLTAELRECKMEIEDKKQELLEMDQALK----ERNWELKQRAAQ------VTHLDMTIR 1154

Query: 304  TIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQV---LQISEEANFEKTKALIQ 360
                  + R ++   ++ +  +L  ++       +Q++ +   LQ ++E   EK   ++Q
Sbjct: 1155 ------EHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQ 1208

Query: 361  CDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREY--MGSKMLILSQNIAQL 418
             +Q   +L+++ ER ++ +   +E  ++ K+  +   T+ +E   +G ++ +  + +   
Sbjct: 1209 NEQEISQLKKEIERTQQRM---KEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNS 1265

Query: 419  EAQVEKVTKEKISAINQLEEIQSQLA----------------SREMDVTKVC-----GEM 457
              ++ +   +++ A  ++E + S+L                 + E+  +KV        M
Sbjct: 1266 HTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARM 1325

Query: 458  RYQLNKTNMEKDEAEK-------EHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQE 510
            + ++ K + E +  ++        H+E  AK     + +   +++L  +L+++K  LE+ 
Sbjct: 1326 QAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEA 1385

Query: 511  QQKAALAREECLRLTELLGESEHQLHLTRQE 541
            Q   +   ++     E++ E+ ++  LT+ E
Sbjct: 1386 QDTVSNLHQQVQDRNEVI-EAANEALLTKGE 1415


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 152/733 (20%), Positives = 308/733 (42%), Gaps = 109/733 (14%)

Query: 50   LSFSTSVGNEDARTAWPELQ-------QSHAVNQLKDLLRQQADKESEVSPSRRRKMSPL 102
            +SFS  +G E A  A  + Q         H +  L++  +Q +++ +        +   +
Sbjct: 597  VSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQN--QQDSERAAHAKEMEALRAKLM 654

Query: 103  RSLEHEETNMPTMHDLVHTINDQ-----SQYIHHL-EAEVKFCKEELSGMKNKIQVVVLE 156
            + ++ +E ++  +   +    DQ        ++ L EAE+K  + E+   K   Q  V++
Sbjct: 655  KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVID 714

Query: 157  NEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHD-NADFGK 215
            N     QLK+  +E+ L    L  AS    +      +     E   +    + NA+  K
Sbjct: 715  N--FTSQLKAT-EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSK 771

Query: 216  AASAGEQLELEKLKLT--YEEKCEIE------ESQLKFLRNDLAE-------YQRTCEDL 260
            A+S   +L+  +LKLT   E   E+       E +L+ L+   AE        QR+ ++ 
Sbjct: 772  ASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQET 831

Query: 261  KEQLKHKE--FLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSA 318
              +L  KE  F + ++   +   L    A  EA   +       +  E+L+K ++ L + 
Sbjct: 832  VNKLHQKEEQFNMLSSDLEK---LRENLADMEAKFREKD-----EREEQLIKAKEKLEND 883

Query: 319  LVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELER---QAERL 375
            +  +     D   +     ++++   +  EE   + TKA      L+K +E    +AE+ 
Sbjct: 884  IAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQS 943

Query: 376  EKELAS--QQEKRAIEK---DMMKKEITKEREYMGSK-----------------MLILSQ 413
            ++E A   ++EK+ +E+   D+ KK  T   +    K                 +  L +
Sbjct: 944  QQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQK 1003

Query: 414  NIAQLEAQVEKVTKEKISAINQLEEIQSQL-ASREMDVTKVCGEMRYQLNKTNMEKDEAE 472
             +   E +++   +E    + +LEE++ Q   ++     +   ++  Q+ K   E   + 
Sbjct: 1004 TLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASL 1063

Query: 473  KEHREFRAKTNRDLE---------------------IKDQEIEKLRIELDESKQHLEQEQ 511
            ++ ++  AK   +L+                     +++Q++E+ R E++  KQ   Q+ 
Sbjct: 1064 EDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKS 1123

Query: 512  QKAALAREECLRLTELLGESEHQL--HLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQ 569
            Q+ +  +EE ++L E LG S  ++  H   +E+ S+  +       Q L+ ++RE +  +
Sbjct: 1124 QQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNN-------QLLEMKKRESKFIK 1176

Query: 570  KIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKR 629
               + +A   K+ +    LLT ++  L KL+ E   L  + E  S K+   + Q  +   
Sbjct: 1177 DADEEKASLQKSISITSALLTEKDAELEKLRNEVTVL--RGENASAKSLHSVVQTLES-- 1232

Query: 630  YTYDKLGKLQRRNEELEEQCVQHGR-VHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLL 688
               DK+ KL+ + + LE Q  ++ R +  +      Q D+  +A   Q+  L S    L 
Sbjct: 1233 ---DKV-KLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQ 1288

Query: 689  LERQSLSEEVDRL 701
             + Q L  +V+ +
Sbjct: 1289 RKNQDLKMKVEMM 1301



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 134/642 (20%), Positives = 264/642 (41%), Gaps = 71/642 (11%)

Query: 83   QQADKESEVSPSR-----RRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVK 137
            QQA +E +VS S+       + + L++ + E+  +   H++ +  N Q       ++E  
Sbjct: 589  QQAMEELKVSFSKGLGTETAEFAELKT-QIEKMRLDYQHEIENLQNQQ-------DSERA 640

Query: 138  FCKEELSGMKNKIQVVVLENEGLQQQLKSQRQE-ETLREQTLLDASGNMHNSWITTGEDS 196
               +E+  ++ K+  V+ E E   + ++S+  + E      + D    +  + I   E  
Sbjct: 641  AHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELE 700

Query: 197  GV-GETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQR 255
             +  + +++    DN      A+  + L+L+ L+    E     +S++K LR  L   ++
Sbjct: 701  VLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEG----KSEMKKLRQQLEAAEK 756

Query: 256  TCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDL 315
              + L+ + K+ E   A++    + G  LK    +  LS+       Q  E L KE   L
Sbjct: 757  QIKHLEIE-KNAESSKASSITRELQGRELKLTNLQENLSEVS-----QVKETLEKELQIL 810

Query: 316  MSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERL 375
                          Q+   S  E V ++ Q  E+ N                L    E+L
Sbjct: 811  KEKFAEASEEAVSVQR---SMQETVNKLHQKEEQFNM---------------LSSDLEKL 852

Query: 376  EKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQ 435
             + LA  + K   EKD  ++++ K +E + + +  + +      +Q+ K+  E       
Sbjct: 853  RENLADMEAKFR-EKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERD 911

Query: 436  LEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEK 495
            +EE+Q +L     + + +   +     K    + EA K+H E + +  R L   ++++E 
Sbjct: 912  VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMET 971

Query: 496  LRIELDESKQHLEQEQQKAALAREECLR-LTELLGESEHQLHLTRQEKDSIQQSFSKEAK 554
               +  E K   E+   +     EE L+ L + L ++E +L   R+E   + Q   +  K
Sbjct: 972  SHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK 1031

Query: 555  -AQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQI 613
             A   +A Q  ++  Q ++QM  +  +T      L + ++T  T  K     L  +L+ +
Sbjct: 1032 QADKAKAAQTAEDAMQIMEQMTKEKTET------LASLEDTKQTNAK-----LQNELDTL 1080

Query: 614  SQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQAT 673
             +     + +L++ K         L   N+++EE      +  ET+KQ   Q  +   A 
Sbjct: 1081 KENNLKNVEELNKSKEL-------LTVENQKMEE----FRKEIETLKQAAAQKSQQLSAL 1129

Query: 674  AQQLVQL---LSKQNQLLLERQSLSEEVDRLRTQLPSMPQSD 712
             ++ V+L   L +    +   Q L EE   L  QL  M + +
Sbjct: 1130 QEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRE 1171



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 132/525 (25%), Positives = 231/525 (44%), Gaps = 94/525 (17%)

Query: 258 EDLKEQLKHKEFLLA---------ANTCNRVGGLCLKCA-------QH----EAVLSQTH 297
           E LKE+ +H E LLA         A   + VG +  + A       QH    EA + Q  
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR 414

Query: 298 TNVHMQTIERLVKERDDLMSALVSVRSSLADTQQR--EASAYEQVKQVLQISEEANF--- 352
           T V     E   +E+ +L++ L   +  + D Q R  E S  +   +V  +SE++     
Sbjct: 415 TMV-----EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMEL 469

Query: 353 EKTKALI--QCDQLRKELERQAER--------LEKELASQQEKRAIEKDMMKKEITKERE 402
           EK  AL   +  +LR+ LE             L +E++S QEK  + +   ++EIT  +E
Sbjct: 470 EKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKE 529

Query: 403 YMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLN 462
           + G++     + I  L    EK++KE        E ++S+L     + + V    + +L 
Sbjct: 530 HFGAREETHQKEIKALYTATEKLSKEN-------ESLKSKLEHANKENSDVIALWKSKLE 582

Query: 463 KTNMEKDEAEKE-----HREFRAKTNRDLEIKDQEIEKLRIELDESKQHL--EQEQQKAA 515
                  +A +E      +    +T    E+K Q IEK+R++     ++L  +Q+ ++AA
Sbjct: 583 TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ-IEKMRLDYQHEIENLQNQQDSERAA 641

Query: 516 LARE-ECLR--LTELLGESEHQLHLTRQEKD---------------SIQQSFSKEAKAQA 557
            A+E E LR  L +++ E E+ L   R + D                +Q++  K  + + 
Sbjct: 642 HAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV 701

Query: 558 LQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKT 617
           LQA+  EQ  T+ I    +Q   TE E+ L L +    L K   E  +  KKL Q  +  
Sbjct: 702 LQAKCNEQ--TKVIDNFTSQLKATE-EKLLDLDA----LRKASSEGKSEMKKLRQQLEAA 754

Query: 618 RSEIAQLSQEKRYTYDKLGKLQRRNE-------ELEEQCVQHGRVHETMKQRLRQL-DKH 669
             +I  L  EK     K   + R  +        L+E   +  +V ET+++ L+ L +K 
Sbjct: 755 EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKF 814

Query: 670 SQATAQ------QLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSM 708
           ++A+ +       + + ++K +Q   +   LS ++++LR  L  M
Sbjct: 815 AEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADM 859



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 53/212 (25%), Positives = 94/212 (44%), Gaps = 24/212 (11%)

Query: 496 LRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKA 555
           L+  L E +QH+EQ   +  L R E  + T  +GE E +L L R   D  Q     EAK 
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHD--QHVLELEAKM 410

Query: 556 QALQ--AQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKK---- 609
             L+   +  ++E  + + Q+E +  K E+ Q+ +   +   +TK   E  T+++K    
Sbjct: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRV---EEESITKGDLEVATVSEKSRIM 467

Query: 610 -LEQISQKTRSEIAQLSQ---------EKRYTYDKLGKLQRRNEELEEQCVQHGRVHETM 659
            LE+       E+A+L +         +   +   L ++    E+LE     H R   ++
Sbjct: 468 ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSL 527

Query: 660 KQRLRQLDKHSQATAQQL---VQLLSKQNQLL 688
           K+     ++  Q   + L    + LSK+N+ L
Sbjct: 528 KEHFGAREETHQKEIKALYTATEKLSKENESL 559


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.124    0.327 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,641,655
Number of Sequences: 37866
Number of extensions: 1075333
Number of successful extensions: 17623
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 311
Number of HSP's successfully gapped in prelim test: 1253
Number of HSP's that attempted gapping in prelim test: 6574
Number of HSP's gapped (non-prelim): 5573
length of query: 713
length of database: 18,247,518
effective HSP length: 109
effective length of query: 604
effective length of database: 14,120,124
effective search space: 8528554896
effective search space used: 8528554896
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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