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Search of human proteins with 27901803
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27901803 protein serine kinase H1 [Homo sapiens]
(424 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27901803 protein serine kinase H1 [Homo sapiens] 850 0.0
gi|14916455 protein serine kinase H2 [Homo sapiens] 476 e-134
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 285 7e-77
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 285 7e-77
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 280 1e-75
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 258 9e-69
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 258 9e-69
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 249 3e-66
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 239 5e-63
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 221 7e-58
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 221 7e-58
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 221 7e-58
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 221 7e-58
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 221 7e-58
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 221 7e-58
gi|83776596 CaM kinase-like vesicle-associated [Homo sapiens] 220 2e-57
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 214 9e-56
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 214 9e-56
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ... 214 1e-55
gi|26051204 calcium/calmodulin-dependent protein kinase II beta ... 214 2e-55
gi|26051214 calcium/calmodulin-dependent protein kinase II beta ... 214 2e-55
gi|26051206 calcium/calmodulin-dependent protein kinase II beta ... 214 2e-55
gi|26051216 calcium/calmodulin-dependent protein kinase II beta ... 214 2e-55
gi|26051218 calcium/calmodulin-dependent protein kinase II beta ... 214 2e-55
gi|26051212 calcium/calmodulin-dependent protein kinase II beta ... 214 2e-55
gi|26051208 calcium/calmodulin-dependent protein kinase II beta ... 214 2e-55
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 211 1e-54
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 211 1e-54
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 210 2e-54
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 210 2e-54
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 850 bits (2196), Expect = 0.0
Identities = 424/424 (100%), Positives = 424/424 (100%)
Query: 1 MGCGTSKVLPEPPKDVQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPAASQYAH 60
MGCGTSKVLPEPPKDVQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPAASQYAH
Sbjct: 1 MGCGTSKVLPEPPKDVQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPAASQYAH 60
Query: 61 PCPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRAT 120
PCPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRAT
Sbjct: 61 PCPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRAT 120
Query: 121 RQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGEL 180
RQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGEL
Sbjct: 121 RQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGEL 180
Query: 181 FDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDF 240
FDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDF
Sbjct: 181 FDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDF 240
Query: 241 GLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDD 300
GLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDD
Sbjct: 241 GLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDD 300
Query: 301 NRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAA 360
NRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAA
Sbjct: 301 NRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAA 360
Query: 361 SSSMKNLHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQ 420
SSSMKNLHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQ
Sbjct: 361 SSSMKNLHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQ 420
Query: 421 QYNG 424
QYNG
Sbjct: 421 QYNG 424
>gi|14916455 protein serine kinase H2 [Homo sapiens]
Length = 385
Score = 476 bits (1225), Expect = e-134
Identities = 252/414 (60%), Positives = 311/414 (75%), Gaps = 41/414 (9%)
Query: 1 MGCGTS-KVLPEPPKDVQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPAASQYA 59
MGCG S KV+P PP + G +AG A
Sbjct: 1 MGCGASRKVVPGPPA------------------------LAWAKHEGQNQAGVGGAG--- 33
Query: 60 HPCPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRA 119
PGP A ++ +R +VA++RAKFDPRV A+YDIKALIG GSFSRVVRVE +
Sbjct: 34 ---PGPEAA------AQAAQRIQVARFRAKFDPRVLARYDIKALIGTGSFSRVVRVEQKT 84
Query: 120 TRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGE 179
T++P+AIK++ET+ REGRE C SEL VLRRV H I+QL+E+FET+++VYMVMELATGGE
Sbjct: 85 TKKPFAIKVMETREREGREACVSELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGE 144
Query: 180 LFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITD 239
LFDR+IA+GSFTERDA R+LQMV DG+RYLHAL ITHR+LKPENLLYYHPG +SKI+ITD
Sbjct: 145 LFDRLIAQGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITD 204
Query: 240 FGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFED 299
FGLA + KK D MKT CGTPEYIAPEVL+RKPYT++VDMWALGVI Y LLSG +PF+D
Sbjct: 205 FGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDD 264
Query: 300 DNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMA 359
+++TRLYR+IL+GKY+Y+GEPWPS+S+LAKDFID+LL ++ G RM+A QAL HPWV++MA
Sbjct: 265 ESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWVITMA 324
Query: 360 ASSSMKNLHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRV-RERELR 412
A SSMKNL R+IS+NL++RAS QS SAQ SS+S S+KSR + +R LR
Sbjct: 325 AGSSMKNLQRAISRNLMQRASPHSQSPGSAQ---SSKSHYSHKSRHMWSKRNLR 375
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 285 bits (728), Expect = 7e-77
Identities = 137/281 (48%), Positives = 195/281 (69%), Gaps = 5/281 (1%)
Query: 98 YDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVC-ESELRVLRRVRHANII 156
++ K +G G+FS VV E +AT + +A+K I K +G+E E+E+ VLR+++H NI+
Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82
Query: 157 QLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITH 216
L +++E+ +Y+VM+L +GGELFDRI+ KG +TE+DA+ +++ VLD V YLH +GI H
Sbjct: 83 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 142
Query: 217 RDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTN 276
RDLKPENLLYY +SKI+I+DFGL+ KGD +M T CGTP Y+APEVL +KPY+
Sbjct: 143 RDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD--VMSTACGTPGYVAPEVLAQKPYSK 200
Query: 277 SVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLL 336
+VD W++GVIAYILL G PF D+N ++L+ QIL+ +Y + W +S+ AKDFI L+
Sbjct: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
Query: 337 TVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLK 377
DP R T QA RHPW+ A + KN+H S+S + K
Sbjct: 261 EKDPNKRYTCEQAARHPWIAGDTALN--KNIHESVSAQIRK 299
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 285 bits (728), Expect = 7e-77
Identities = 137/281 (48%), Positives = 195/281 (69%), Gaps = 5/281 (1%)
Query: 98 YDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVC-ESELRVLRRVRHANII 156
++ K +G G+FS VV E +AT + +A+K I K +G+E E+E+ VLR+++H NI+
Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82
Query: 157 QLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITH 216
L +++E+ +Y+VM+L +GGELFDRI+ KG +TE+DA+ +++ VLD V YLH +GI H
Sbjct: 83 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 142
Query: 217 RDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTN 276
RDLKPENLLYY +SKI+I+DFGL+ KGD +M T CGTP Y+APEVL +KPY+
Sbjct: 143 RDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD--VMSTACGTPGYVAPEVLAQKPYSK 200
Query: 277 SVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLL 336
+VD W++GVIAYILL G PF D+N ++L+ QIL+ +Y + W +S+ AKDFI L+
Sbjct: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
Query: 337 TVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLK 377
DP R T QA RHPW+ A + KN+H S+S + K
Sbjct: 261 EKDPNKRYTCEQAARHPWIAGDTALN--KNIHESVSAQIRK 299
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 280 bits (717), Expect = 1e-75
Identities = 136/281 (48%), Positives = 194/281 (69%), Gaps = 5/281 (1%)
Query: 98 YDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE-VCESELRVLRRVRHANII 156
YD + ++G G+FS V+ E + T++ AIK I + EG+E E+E+ VL +++H NI+
Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIV 79
Query: 157 QLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITH 216
L +++E+ +Y++M+L +GGELFDRI+ KG +TERDA+R++ VLD V+YLH LGI H
Sbjct: 80 ALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVH 139
Query: 217 RDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTN 276
RDLKPENLLYY DSKI+I+DFGL+ G ++ T CGTP Y+APEVL +KPY+
Sbjct: 140 RDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGS--VLSTACGTPGYVAPEVLAQKPYSK 197
Query: 277 SVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLL 336
+VD W++GVIAYILL G PF D+N +L+ QIL+ +Y + W +S+ AKDFI L+
Sbjct: 198 AVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLM 257
Query: 337 TVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLK 377
DP R T QAL+HPW+ A KN+H+S+S+ + K
Sbjct: 258 EKDPEKRFTCEQALQHPWIAGDTALD--KNIHQSVSEQIKK 296
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 258 bits (658), Expect = 9e-69
Identities = 133/285 (46%), Positives = 186/285 (65%), Gaps = 6/285 (2%)
Query: 94 VTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE-VCESELRVLRRVRH 152
+++ Y+I+ +G G+FS VV + R + A+K I K G+E + E+E+ VLRR+ H
Sbjct: 28 ISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISH 87
Query: 153 ANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHAL 212
NI+ L +V E+ +Y+ MEL TGGELFDRI+ +GS+TE+DA+ ++ VL V YLH+L
Sbjct: 88 PNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSL 147
Query: 213 GITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRK 272
GI HRDLKPENLLY P DSKI+++DFGL+ + ++ T CGTP Y+APE+L +K
Sbjct: 148 GIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGN---MLGTACGTPGYVAPELLEQK 204
Query: 273 PYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFI 332
PY +VD+WALGVI+YILL G PF D++ L+ QILR Y + W +S AKDFI
Sbjct: 205 PYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFI 264
Query: 333 DRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLK 377
LL DP R T QALRH W+ A +++ S+S+ + K
Sbjct: 265 RHLLERDPQKRFTCQQALRHLWISGDTAFD--RDILGSVSEQIRK 307
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 258 bits (658), Expect = 9e-69
Identities = 133/285 (46%), Positives = 186/285 (65%), Gaps = 6/285 (2%)
Query: 94 VTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE-VCESELRVLRRVRH 152
+++ Y+I+ +G G+FS VV + R + A+K I K G+E + E+E+ VLRR+ H
Sbjct: 94 ISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISH 153
Query: 153 ANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHAL 212
NI+ L +V E+ +Y+ MEL TGGELFDRI+ +GS+TE+DA+ ++ VL V YLH+L
Sbjct: 154 PNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSL 213
Query: 213 GITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRK 272
GI HRDLKPENLLY P DSKI+++DFGL+ + ++ T CGTP Y+APE+L +K
Sbjct: 214 GIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGN---MLGTACGTPGYVAPELLEQK 270
Query: 273 PYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFI 332
PY +VD+WALGVI+YILL G PF D++ L+ QILR Y + W +S AKDFI
Sbjct: 271 PYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFI 330
Query: 333 DRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLK 377
LL DP R T QALRH W+ A +++ S+S+ + K
Sbjct: 331 RHLLERDPQKRFTCQQALRHLWISGDTAFD--RDILGSVSEQIRK 373
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 249 bits (636), Expect = 3e-66
Identities = 124/269 (46%), Positives = 174/269 (64%), Gaps = 9/269 (3%)
Query: 103 LIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVF 162
++G G+FS V V+ R T + +A+K I+ E+E+ VL++++H NI+ L +++
Sbjct: 28 VLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVTLEDIY 87
Query: 163 ETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPE 222
E+ Y+VM+L +GGELFDRI+ +G +TE+DA+ V+Q VL V+YLH GI HRDLKPE
Sbjct: 88 ESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPE 147
Query: 223 NLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWA 282
NLLY P +SKI+ITDFGL+ + G +M T CGTP Y+APEVL +KPY+ +VD W+
Sbjct: 148 NLLYLTPEENSKIMITDFGLSKMEQNG---IMSTACGTPGYVAPEVLAQKPYSKAVDCWS 204
Query: 283 LGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGA 342
+GVI YILL G PF ++ ++L+ +I G Y + W +S AKDFI LL DP
Sbjct: 205 IGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNE 264
Query: 343 RMTALQALRHPWVVSMAASSSMKNLHRSI 371
R T +AL HPW+ A LHR I
Sbjct: 265 RYTCEKALSHPWIDGNTA------LHRDI 287
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 239 bits (609), Expect = 5e-63
Identities = 131/316 (41%), Positives = 194/316 (61%), Gaps = 12/316 (3%)
Query: 98 YDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQ 157
+++++ +GRG+ S V R + + T++PYA+K++ K +++ +E+ VL R+ H NII+
Sbjct: 46 FEVESELGRGATSIVYRCKQKGTQKPYALKVL--KKTVDKKIVRTEIGVLLRLSHPNIIK 103
Query: 158 LVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHR 217
L E+FET + +V+EL TGGELFDRI+ KG ++ERDA ++ +L+ V YLH GI HR
Sbjct: 104 LKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHR 163
Query: 218 DLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNS 277
DLKPENLLY P D+ + I DFGL+ + LMKT CGTP Y APE+L Y
Sbjct: 164 DLKPENLLYATPAPDAPLKIADFGLSKIVE--HQVLMKTVCGTPGYCAPEILRGCAYGPE 221
Query: 278 VDMWALGVIAYILLSGTMPFEDDNRTR-LYRQILRGKYSYSGEPWPSVSNLAKDFIDRLL 336
VDMW++G+I YILL G PF D+ + ++R+IL +Y + W VS AKD + +L+
Sbjct: 222 VDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLI 281
Query: 337 TVDPGARMTALQALRHPWVVSMAAS-----SSMKNLHRSISQNLLKRASSRCQSTKSAQS 391
+DP R+T QAL+HPWV AA+ ++ K L ++ LK A ++ S
Sbjct: 282 VLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGS 341
Query: 392 TRSSRST--RSNKSRR 405
SS + S+K+ R
Sbjct: 342 ASSSHGSIQESHKASR 357
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 221 bits (564), Expect = 7e-58
Identities = 120/292 (41%), Positives = 177/292 (60%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + +G+G+FS V R T Q YA K+I TK R+ E E R+ R +
Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H NI++L + + Y+V +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 128
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
GI HRDLKPENLL + + + DFGLA +GD GTP Y++PEVL
Sbjct: 129 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
+ PY VDMWA GVI YILL G PF D+++ RLY+QI G Y + W +V+ AKD
Sbjct: 188 KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 247
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA +AL+HPW+ + +SM +HR + + LK+ ++R
Sbjct: 248 LINKMLTINPAKRITASEALKHPWICQRSTVASM--MHRQETVDCLKKFNAR 297
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 221 bits (564), Expect = 7e-58
Identities = 120/292 (41%), Positives = 177/292 (60%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + +G+G+FS V R T Q YA K+I TK R+ E E R+ R +
Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H NI++L + + Y+V +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 128
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
GI HRDLKPENLL + + + DFGLA +GD GTP Y++PEVL
Sbjct: 129 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
+ PY VDMWA GVI YILL G PF D+++ RLY+QI G Y + W +V+ AKD
Sbjct: 188 KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 247
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA +AL+HPW+ + +SM +HR + + LK+ ++R
Sbjct: 248 LINKMLTINPAKRITASEALKHPWICQRSTVASM--MHRQETVDCLKKFNAR 297
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 221 bits (564), Expect = 7e-58
Identities = 120/292 (41%), Positives = 177/292 (60%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + +G+G+FS V R T Q YA K+I TK R+ E E R+ R +
Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H NI++L + + Y+V +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 128
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
GI HRDLKPENLL + + + DFGLA +GD GTP Y++PEVL
Sbjct: 129 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
+ PY VDMWA GVI YILL G PF D+++ RLY+QI G Y + W +V+ AKD
Sbjct: 188 KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 247
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA +AL+HPW+ + +SM +HR + + LK+ ++R
Sbjct: 248 LINKMLTINPAKRITASEALKHPWICQRSTVASM--MHRQETVDCLKKFNAR 297
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 221 bits (564), Expect = 7e-58
Identities = 120/292 (41%), Positives = 177/292 (60%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + +G+G+FS V R T Q YA K+I TK R+ E E R+ R +
Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H NI++L + + Y+V +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 128
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
GI HRDLKPENLL + + + DFGLA +GD GTP Y++PEVL
Sbjct: 129 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
+ PY VDMWA GVI YILL G PF D+++ RLY+QI G Y + W +V+ AKD
Sbjct: 188 KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 247
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA +AL+HPW+ + +SM +HR + + LK+ ++R
Sbjct: 248 LINKMLTINPAKRITASEALKHPWICQRSTVASM--MHRQETVDCLKKFNAR 297
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 221 bits (564), Expect = 7e-58
Identities = 120/292 (41%), Positives = 177/292 (60%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + +G+G+FS V R T Q YA K+I TK R+ E E R+ R +
Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H NI++L + + Y+V +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 128
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
GI HRDLKPENLL + + + DFGLA +GD GTP Y++PEVL
Sbjct: 129 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
+ PY VDMWA GVI YILL G PF D+++ RLY+QI G Y + W +V+ AKD
Sbjct: 188 KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 247
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA +AL+HPW+ + +SM +HR + + LK+ ++R
Sbjct: 248 LINKMLTINPAKRITASEALKHPWICQRSTVASM--MHRQETVDCLKKFNAR 297
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 221 bits (564), Expect = 7e-58
Identities = 120/292 (41%), Positives = 177/292 (60%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + +G+G+FS V R T Q YA K+I TK R+ E E R+ R +
Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H NI++L + + Y+V +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 128
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
GI HRDLKPENLL + + + DFGLA +GD GTP Y++PEVL
Sbjct: 129 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
+ PY VDMWA GVI YILL G PF D+++ RLY+QI G Y + W +V+ AKD
Sbjct: 188 KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 247
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA +AL+HPW+ + +SM +HR + + LK+ ++R
Sbjct: 248 LINKMLTINPAKRITASEALKHPWICQRSTVASM--MHRQETVDCLKKFNAR 297
>gi|83776596 CaM kinase-like vesicle-associated [Homo sapiens]
Length = 501
Score = 220 bits (561), Expect = 2e-57
Identities = 125/316 (39%), Positives = 194/316 (61%), Gaps = 16/316 (5%)
Query: 94 VTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKY-REGREVCESELRVLRRVRH 152
VT +YD+ +I F + R + + T + + K + + R+ R+ ++E+ +L+ V+H
Sbjct: 20 VTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMVKH 79
Query: 153 ANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHAL 212
NI+QLV+VF T++ ++ +ELATG E+FD I+ +G ++ERD + V++ VL+ V YLH+L
Sbjct: 80 PNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAYLHSL 139
Query: 213 GITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRK 272
I HR+LK ENL+YY+ +SKI+I+DF LA K ++ L+K CGTPEY+APEV+ R+
Sbjct: 140 KIVHRNLKLENLVYYNRLKNSKIVISDFHLA----KLENGLIKEPCGTPEYLAPEVVGRQ 195
Query: 273 PYTNSVDMWALGVIAYILLSGTMPF-----EDD---NRTRLYRQILRGKYSYSGEPWPSV 324
Y VD WA+GVI YILLSG PF EDD + L+R+IL G Y + W +
Sbjct: 196 RYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDI 255
Query: 325 SNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSRCQ 384
S AKD + RL+ V+ R+TA +A+ H W+ AAS KN+ + + K +R +
Sbjct: 256 SQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASD--KNIKDGVCAQIEKN-FARAK 312
Query: 385 STKSAQSTRSSRSTRS 400
K+ + T + R+
Sbjct: 313 WKKAVRVTTLMKRLRA 328
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 214 bits (546), Expect = 9e-56
Identities = 114/292 (39%), Positives = 176/292 (60%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + +G+G+FS V R Q YA K+I TK R+ E E R+ R +
Sbjct: 8 RFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLL 67
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H NI++L + + Y++ +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 68 KHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 127
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
+G+ HRDLKPENLL + + + DFGLA +G+ GTP Y++PEVL
Sbjct: 128 QMGVVHRDLKPENLLLASKLKGAAVKLADFGLA-IEVEGEQQAWFGFAGTPGYLSPEVLR 186
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
+ PY VD+WA GVI YILL G PF D+++ RLY+QI G Y + W +V+ AKD
Sbjct: 187 KDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 246
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA +AL+HPW+ + +S +HR + + LK+ ++R
Sbjct: 247 LINKMLTINPSKRITAAEALKHPWISHRSTVASC--MHRQETVDCLKKFNAR 296
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 214 bits (546), Expect = 9e-56
Identities = 114/292 (39%), Positives = 176/292 (60%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + +G+G+FS V R Q YA K+I TK R+ E E R+ R +
Sbjct: 8 RFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLL 67
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H NI++L + + Y++ +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 68 KHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 127
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
+G+ HRDLKPENLL + + + DFGLA +G+ GTP Y++PEVL
Sbjct: 128 QMGVVHRDLKPENLLLASKLKGAAVKLADFGLA-IEVEGEQQAWFGFAGTPGYLSPEVLR 186
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
+ PY VD+WA GVI YILL G PF D+++ RLY+QI G Y + W +V+ AKD
Sbjct: 187 KDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 246
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA +AL+HPW+ + +S +HR + + LK+ ++R
Sbjct: 247 LINKMLTINPSKRITAAEALKHPWISHRSTVASC--MHRQETVDCLKKFNAR 296
>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
isoform 4 [Homo sapiens]
Length = 517
Score = 214 bits (545), Expect = 1e-55
Identities = 120/313 (38%), Positives = 185/313 (59%), Gaps = 5/313 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + IG+G+FS V R T YA K+I TK R+ E E R+ R +
Sbjct: 9 RFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H+NI++L + + Y+V +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 69 KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 128
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
+G+ HRDLKPENLL + + + DFGLA +GD GTP Y++PEVL
Sbjct: 129 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
++ Y VD+WA GVI YILL G PF D+++ +LY+QI G Y + W +V+ AK+
Sbjct: 188 KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 247
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSRCQSTKSAQ 390
I+++LT++P R+TA +AL+HPWV + +SM +HR + LK+ ++R + +
Sbjct: 248 LINQMLTINPAKRITAHEALKHPWVCQRSTVASM--MHRQETVECLKKFNARRKLKGAIL 305
Query: 391 STRSSRSTRSNKS 403
+T + S KS
Sbjct: 306 TTMLATRNFSAKS 318
>gi|26051204 calcium/calmodulin-dependent protein kinase II beta
isoform 1 [Homo sapiens]
Length = 666
Score = 214 bits (544), Expect = 2e-55
Identities = 116/292 (39%), Positives = 177/292 (60%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + IG+G+FS V R T YA K+I TK R+ E E R+ R +
Sbjct: 9 RFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H+NI++L + + Y+V +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 69 KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 128
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
+G+ HRDLKPENLL + + + DFGLA +GD GTP Y++PEVL
Sbjct: 129 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
++ Y VD+WA GVI YILL G PF D+++ +LY+QI G Y + W +V+ AK+
Sbjct: 188 KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 247
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA +AL+HPWV + +SM +HR + LK+ ++R
Sbjct: 248 LINQMLTINPAKRITAHEALKHPWVCQRSTVASM--MHRQETVECLKKFNAR 297
>gi|26051214 calcium/calmodulin-dependent protein kinase II beta
isoform 6 [Homo sapiens]
Length = 492
Score = 214 bits (544), Expect = 2e-55
Identities = 116/292 (39%), Positives = 177/292 (60%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + IG+G+FS V R T YA K+I TK R+ E E R+ R +
Sbjct: 9 RFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H+NI++L + + Y+V +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 69 KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 128
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
+G+ HRDLKPENLL + + + DFGLA +GD GTP Y++PEVL
Sbjct: 129 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
++ Y VD+WA GVI YILL G PF D+++ +LY+QI G Y + W +V+ AK+
Sbjct: 188 KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 247
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA +AL+HPWV + +SM +HR + LK+ ++R
Sbjct: 248 LINQMLTINPAKRITAHEALKHPWVCQRSTVASM--MHRQETVECLKKFNAR 297
>gi|26051206 calcium/calmodulin-dependent protein kinase II beta
isoform 2 [Homo sapiens]
Length = 542
Score = 214 bits (544), Expect = 2e-55
Identities = 116/292 (39%), Positives = 177/292 (60%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + IG+G+FS V R T YA K+I TK R+ E E R+ R +
Sbjct: 9 RFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H+NI++L + + Y+V +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 69 KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 128
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
+G+ HRDLKPENLL + + + DFGLA +GD GTP Y++PEVL
Sbjct: 129 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
++ Y VD+WA GVI YILL G PF D+++ +LY+QI G Y + W +V+ AK+
Sbjct: 188 KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 247
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA +AL+HPWV + +SM +HR + LK+ ++R
Sbjct: 248 LINQMLTINPAKRITAHEALKHPWVCQRSTVASM--MHRQETVECLKKFNAR 297
>gi|26051216 calcium/calmodulin-dependent protein kinase II beta
isoform 7 [Homo sapiens]
Length = 479
Score = 214 bits (544), Expect = 2e-55
Identities = 116/292 (39%), Positives = 177/292 (60%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + IG+G+FS V R T YA K+I TK R+ E E R+ R +
Sbjct: 9 RFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H+NI++L + + Y+V +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 69 KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 128
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
+G+ HRDLKPENLL + + + DFGLA +GD GTP Y++PEVL
Sbjct: 129 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
++ Y VD+WA GVI YILL G PF D+++ +LY+QI G Y + W +V+ AK+
Sbjct: 188 KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 247
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA +AL+HPWV + +SM +HR + LK+ ++R
Sbjct: 248 LINQMLTINPAKRITAHEALKHPWVCQRSTVASM--MHRQETVECLKKFNAR 297
>gi|26051218 calcium/calmodulin-dependent protein kinase II beta
isoform 8 [Homo sapiens]
Length = 449
Score = 214 bits (544), Expect = 2e-55
Identities = 116/292 (39%), Positives = 177/292 (60%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + IG+G+FS V R T YA K+I TK R+ E E R+ R +
Sbjct: 9 RFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H+NI++L + + Y+V +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 69 KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 128
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
+G+ HRDLKPENLL + + + DFGLA +GD GTP Y++PEVL
Sbjct: 129 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
++ Y VD+WA GVI YILL G PF D+++ +LY+QI G Y + W +V+ AK+
Sbjct: 188 KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 247
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA +AL+HPWV + +SM +HR + LK+ ++R
Sbjct: 248 LINQMLTINPAKRITAHEALKHPWVCQRSTVASM--MHRQETVECLKKFNAR 297
>gi|26051212 calcium/calmodulin-dependent protein kinase II beta
isoform 5 [Homo sapiens]
Length = 503
Score = 214 bits (544), Expect = 2e-55
Identities = 116/292 (39%), Positives = 177/292 (60%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + IG+G+FS V R T YA K+I TK R+ E E R+ R +
Sbjct: 9 RFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H+NI++L + + Y+V +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 69 KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 128
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
+G+ HRDLKPENLL + + + DFGLA +GD GTP Y++PEVL
Sbjct: 129 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
++ Y VD+WA GVI YILL G PF D+++ +LY+QI G Y + W +V+ AK+
Sbjct: 188 KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 247
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA +AL+HPWV + +SM +HR + LK+ ++R
Sbjct: 248 LINQMLTINPAKRITAHEALKHPWVCQRSTVASM--MHRQETVECLKKFNAR 297
>gi|26051208 calcium/calmodulin-dependent protein kinase II beta
isoform 3 [Homo sapiens]
Length = 518
Score = 214 bits (544), Expect = 2e-55
Identities = 116/292 (39%), Positives = 177/292 (60%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T +Y + IG+G+FS V R T YA K+I TK R+ E E R+ R +
Sbjct: 9 RFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H+NI++L + + Y+V +L TGGELF+ I+A+ ++E DA+ +Q +L+ V + H
Sbjct: 69 KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 128
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
+G+ HRDLKPENLL + + + DFGLA +GD GTP Y++PEVL
Sbjct: 129 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
++ Y VD+WA GVI YILL G PF D+++ +LY+QI G Y + W +V+ AK+
Sbjct: 188 KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 247
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA +AL+HPWV + +SM +HR + LK+ ++R
Sbjct: 248 LINQMLTINPAKRITAHEALKHPWVCQRSTVASM--MHRQETVECLKKFNAR 297
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 211 bits (537), Expect = 1e-54
Identities = 116/267 (43%), Positives = 166/267 (62%), Gaps = 8/267 (2%)
Query: 95 TAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHAN 154
T Y+IK IG GS+S R H+AT YA+K+I+ R+ E E +LR +H N
Sbjct: 420 TDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEI---LLRYGQHPN 476
Query: 155 IIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGI 214
II L +V++ + VY+VMEL GGEL DRI+ + F+ER+A+ VL + + YLH+ G+
Sbjct: 477 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGV 536
Query: 215 THRDLKPENLLYY-HPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKP 273
HRDLKP N+LY G+ I + DFG A + G+ LM T C T ++APEVL R+
Sbjct: 537 VHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLM-TPCYTANFVAPEVLKRQG 595
Query: 274 YTNSVDMWALGVIAYILLSGTMPF---EDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
Y + D+W+LG++ Y +L+G PF DD + +I GKY+ SG W S+S+ AKD
Sbjct: 596 YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKD 655
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVS 357
+ ++L VDP R+TA+Q L+HPWVV+
Sbjct: 656 VVSKMLHVDPHQRLTAMQVLKHPWVVN 682
Score = 134 bits (338), Expect = 1e-31
Identities = 89/279 (31%), Positives = 156/279 (55%), Gaps = 18/279 (6%)
Query: 90 FDPRVTAKYDIKALIGRGSFSRVV---RVEHRATRQPYAIKMIETKYREGREVCESELR- 145
F+ +++++ ++G+GS+ +V +V+ Q YA+K+++ + R+ S++
Sbjct: 59 FEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMER 118
Query: 146 -VLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLD 204
+L V H I++L F+T+ ++Y++++ GG+LF R+ + FTE D L +
Sbjct: 119 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 178
Query: 205 GVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYI 264
+ +LH+LGI +RDLKPEN+L G I ITDFGL S D + CGT EY+
Sbjct: 179 ALDHLHSLGIIYRDLKPENILLDEEG---HIKITDFGL-SKEAIDHDKRAYSFCGTIEYM 234
Query: 265 APEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSV 324
APEV+ R+ +T S D W+ GV+ + +L+G++PF+ +R IL+ K G P +
Sbjct: 235 APEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKL---GMP-QFL 290
Query: 325 SNLAKDFIDRLLTVDP----GARMTALQAL-RHPWVVSM 358
S A+ + L +P GA + ++ + RHP+ V++
Sbjct: 291 SGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTI 329
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 211 bits (537), Expect = 1e-54
Identities = 116/267 (43%), Positives = 166/267 (62%), Gaps = 8/267 (2%)
Query: 95 TAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHAN 154
T Y+IK IG GS+S R H+AT YA+K+I+ R+ E E +LR +H N
Sbjct: 412 TDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEI---LLRYGQHPN 468
Query: 155 IIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGI 214
II L +V++ + VY+VMEL GGEL DRI+ + F+ER+A+ VL + + YLH+ G+
Sbjct: 469 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGV 528
Query: 215 THRDLKPENLLYY-HPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKP 273
HRDLKP N+LY G+ I + DFG A + G+ LM T C T ++APEVL R+
Sbjct: 529 VHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLM-TPCYTANFVAPEVLKRQG 587
Query: 274 YTNSVDMWALGVIAYILLSGTMPF---EDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
Y + D+W+LG++ Y +L+G PF DD + +I GKY+ SG W S+S+ AKD
Sbjct: 588 YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKD 647
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVS 357
+ ++L VDP R+TA+Q L+HPWVV+
Sbjct: 648 VVSKMLHVDPHQRLTAMQVLKHPWVVN 674
Score = 134 bits (338), Expect = 1e-31
Identities = 89/279 (31%), Positives = 156/279 (55%), Gaps = 18/279 (6%)
Query: 90 FDPRVTAKYDIKALIGRGSFSRVV---RVEHRATRQPYAIKMIETKYREGREVCESELR- 145
F+ +++++ ++G+GS+ +V +V+ Q YA+K+++ + R+ S++
Sbjct: 51 FEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMER 110
Query: 146 -VLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLD 204
+L V H I++L F+T+ ++Y++++ GG+LF R+ + FTE D L +
Sbjct: 111 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 170
Query: 205 GVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYI 264
+ +LH+LGI +RDLKPEN+L G I ITDFGL S D + CGT EY+
Sbjct: 171 ALDHLHSLGIIYRDLKPENILLDEEG---HIKITDFGL-SKEAIDHDKRAYSFCGTIEYM 226
Query: 265 APEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSV 324
APEV+ R+ +T S D W+ GV+ + +L+G++PF+ +R IL+ K G P +
Sbjct: 227 APEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKL---GMP-QFL 282
Query: 325 SNLAKDFIDRLLTVDP----GARMTALQAL-RHPWVVSM 358
S A+ + L +P GA + ++ + RHP+ V++
Sbjct: 283 SGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTI 321
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 210 bits (534), Expect = 2e-54
Identities = 114/292 (39%), Positives = 175/292 (59%), Gaps = 5/292 (1%)
Query: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE--VCESELRVLRRV 150
R T Y + +G+G+FS V R + + Q YA K+I TK R+ E E R+ R +
Sbjct: 9 RFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 151 RHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLH 210
+H NI++L + + Y+V +L TGGELF+ I+A+ ++E DA+ + +L+ V ++H
Sbjct: 69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIH 128
Query: 211 ALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLV 270
I HRDLKPENLL + + + DFGLA +G+ GTP Y++PEVL
Sbjct: 129 QHDIVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGEQQAWFGFAGTPGYLSPEVLR 187
Query: 271 RKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKD 330
+ PY VD+WA GVI YILL G PF D+++ +LY+QI G Y + W +V+ AK+
Sbjct: 188 KDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 247
Query: 331 FIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSR 382
I+++LT++P R+TA QAL+HPWV + +SM +HR + L++ ++R
Sbjct: 248 LINQMLTINPAKRITADQALKHPWVCQRSTVASM--MHRQETVECLRKFNAR 297
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 210 bits (534), Expect = 2e-54
Identities = 111/266 (41%), Positives = 162/266 (60%), Gaps = 8/266 (3%)
Query: 94 VTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE-VCESELRVLRRVRH 152
+T +Y + IG G+F+ V R+T + YA+K+I+ G+E + ++E+ +LRRV+H
Sbjct: 386 ITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKH 445
Query: 153 ANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHAL 212
NI+ L+E + +Y+VMEL GG+LFD I + +TERDA+ +L + ++YLH+L
Sbjct: 446 PNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSL 505
Query: 213 GITHRDLKPENLLYY-HPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVR 271
I HRD+KPENLL Y H + + DFGLA+ D + T CGTP Y+APE++
Sbjct: 506 NIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATI----VDGPLYTVCGTPTYVAPEIIAE 561
Query: 272 KPYTNSVDMWALGVIAYILLSGTMPF--EDDNRTRLYRQILRGKYSYSGEPWPSVSNLAK 329
Y VD+WA GVI YILL G PF D++ L+ QIL G+ + W +VS+ AK
Sbjct: 562 TGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAK 621
Query: 330 DFIDRLLTVDPGARMTALQALRHPWV 355
+ I +L VD R +A+Q L HPWV
Sbjct: 622 ELITMMLLVDVDQRFSAVQVLEHPWV 647
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,262,915
Number of Sequences: 37866
Number of extensions: 736555
Number of successful extensions: 6445
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 632
Number of HSP's successfully gapped in prelim test: 188
Number of HSP's that attempted gapping in prelim test: 3921
Number of HSP's gapped (non-prelim): 1131
length of query: 424
length of database: 18,247,518
effective HSP length: 105
effective length of query: 319
effective length of database: 14,271,588
effective search space: 4552636572
effective search space used: 4552636572
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.