Search of human proteins with 27894385

Search of human proteins with 27894385

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27894385 frizzled 5 precursor [Homo sapiens]
         (585 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27894385 frizzled 5 precursor [Homo sapiens]                      1231   0.0  
gi|13994190 frizzled 8 [Homo sapiens]                                 790   0.0  
gi|4503827 frizzled 2 [Homo sapiens]                                  553   e-157
gi|4503833 frizzled 7 [Homo sapiens]                                  535   e-152
gi|4503825 frizzled 1 [Homo sapiens]                                  520   e-147
gi|6005762 frizzled 10 [Homo sapiens]                                 486   e-137
gi|4503835 frizzled 9 [Homo sapiens]                                  477   e-134
gi|22547161 frizzled 4 [Homo sapiens]                                 439   e-123
gi|8393378 frizzled 3 [Homo sapiens]                                  366   e-101
gi|34734079 frizzled 6 [Homo sapiens]                                 353   3e-97
gi|5032099 smoothened [Homo sapiens]                                  183   4e-46
gi|38455388 frizzled-related protein [Homo sapiens]                   140   2e-33
gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]      133   5e-31
gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]       105   9e-23
gi|48475052 secreted frizzled-related protein 2 precursor [Homo ...   105   2e-22
gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]         92   2e-18
gi|29244926 corin [Homo sapiens]                                       86   7e-17
gi|13899255 membrane frizzled-related protein [Homo sapiens]           69   1e-11
gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]      68   2e-11
gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]                65   2e-10
gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Ho...    46   8e-05
gi|119943125 G protein-coupled receptor 64 isoform 3 [Homo sapiens]    40   0.008
gi|119943116 G protein-coupled receptor 64 isoform 2 [Homo sapiens]    40   0.008
gi|119943120 G protein-coupled receptor 64 isoform 1 [Homo sapiens]    40   0.008
gi|119943129 G protein-coupled receptor 64 isoform 4 [Homo sapiens]    40   0.008
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo...    39   0.017
gi|74048357 G protein-coupled receptor 126 alpha 1 precursor [Ho...    38   0.023
gi|50355941 G protein-coupled receptor 126 beta 1 precursor [Hom...    38   0.023
gi|74048422 G protein-coupled receptor 126 alpha 2 precursor [Ho...    38   0.023
gi|74048403 G protein-coupled receptor 126 beta 2 precursor [Hom...    38   0.023

>gi|27894385 frizzled 5 precursor [Homo sapiens]
          Length = 585

 Score = 1231 bits (3186), Expect = 0.0
 Identities = 585/585 (100%), Positives = 585/585 (100%)

Query: 1   MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQ 60
           MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQ
Sbjct: 1   MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQ 60

Query: 61  DEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLM 120
           DEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLM
Sbjct: 61  DEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLM 120

Query: 121 RQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPASGG 180
           RQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPASGG
Sbjct: 121 RQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPASGG 180

Query: 181 ECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSADERTFATFWIG 240
           ECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSADERTFATFWIG
Sbjct: 181 ECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSADERTFATFWIG 240

Query: 241 LWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSR 300
           LWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSR
Sbjct: 241 LWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSR 300

Query: 301 EHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYF 360
           EHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYF
Sbjct: 301 EHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYF 360

Query: 361 HLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLL 420
           HLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLL
Sbjct: 361 HLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLL 420

Query: 421 AGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEA 480
           AGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEA
Sbjct: 421 AGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEA 480

Query: 481 ALTCACPGHDTGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRCCCR 540
           ALTCACPGHDTGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRCCCR
Sbjct: 481 ALTCACPGHDTGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRCCCR 540

Query: 541 PRRGHKSGGAMAAGDYPEASAALTGRTGPPGPAATYHKQVSLSHV 585
           PRRGHKSGGAMAAGDYPEASAALTGRTGPPGPAATYHKQVSLSHV
Sbjct: 541 PRRGHKSGGAMAAGDYPEASAALTGRTGPPGPAATYHKQVSLSHV 585


>gi|13994190 frizzled 8 [Homo sapiens]
          Length = 694

 Score =  790 bits (2039), Expect = 0.0
 Identities = 413/683 (60%), Positives = 464/683 (67%), Gaps = 115/683 (16%)

Query: 14  LLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPL 73
           L LL +  G AAA++K   CQEITVP+C+GIGYN T+MPNQFNHDTQDEAGLEVHQFWPL
Sbjct: 16  LALLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPL 75

Query: 74  VEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSC 133
           VEIQCSPDL+FFLCSMYTPICL DY KPLPPCRSVCERAKAGC+PLMRQYGFAWP+RM C
Sbjct: 76  VEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRC 135

Query: 134 DRLPVLGRDAEVLCMDYNRSEATTA---PPRPFPAKPTLPG-----------PPGA---- 175
           DRLP  G + + LCMDYNR++ TTA   PPR  P  P  PG           PPGA    
Sbjct: 136 DRLPEQG-NPDTLCMDYNRTDLTTAAPSPPRRLPPPP--PGEQPPSGSGHGRPPGARPPH 192

Query: 176 ---------------PASGG------ECPAGGPFV----CKCREPFVPILKESHPLYNKV 210
                          PA GG        P GG       C+CR P V +  E HPLYN+V
Sbjct: 193 RGGGRGGGGGDAAAPPARGGGGGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRV 252

Query: 211 RTGQVPNCAVPCYQPSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERP 270
           +TGQ+ NCA+PC+ P FS DER F  FWIGLWSVLCF+ST  TV+TFLIDMERF+YPERP
Sbjct: 253 KTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERP 312

Query: 271 IIFLSACYLCVSLGFLVRLVVGHASVACS------------------------------- 299
           IIFLSACYL VS+G+LVRLV GH  VACS                               
Sbjct: 313 IIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAGAGAAGAGAGGPGG 372

Query: 300 --------REHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNE 351
                       H+ YETTGPALCT+VFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNE
Sbjct: 373 RGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNE 432

Query: 352 AIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLY 411
           AIAGY+QYFHLAAWL+PSVKSI  LALSSVDGDPVAGICYVGNQ+L++LRGFVL PLV+Y
Sbjct: 433 AIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIY 492

Query: 412 LLVGTLFLLAGFVSLFRIRSVIKQ--GGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYL 469
           L +GT+FLLAGFVSLFRIRSVIKQ  G TKT KLEKLMIR+G+FT+LYTVPA++VVAC  
Sbjct: 493 LFIGTMFLLAGFVSLFRIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLF 552

Query: 470 YEQHYRESWEAALTCACPGHDTGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVES 529
           YEQH R  WEA   C C          +P+Y V MLKYFMCLVVGITSGVW+WSGKT+ES
Sbjct: 553 YEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLES 612

Query: 530 WRRFTSRCCCRPRRGHKSG--GAMAAGD-------------------------YPEASAA 562
           WR   +RCC   +     G  GA AAG                          Y + S  
Sbjct: 613 WRSLCTRCCWASKGAAVGGGAGATAAGGGGGPGGGGGGGPGGGGGPGGGGGSLYSDVSTG 672

Query: 563 LTGRTGPPGPAATYHKQVSLSHV 585
           LT R+G    + +Y KQ+ LS V
Sbjct: 673 LTWRSG-TASSVSYPKQMPLSQV 694


>gi|4503827 frizzled 2 [Homo sapiens]
          Length = 565

 Score =  553 bits (1425), Expect = e-157
 Identities = 291/570 (51%), Positives = 369/570 (64%), Gaps = 53/570 (9%)

Query: 3   RPDPSAPPSLLLLLLAQLVGRAAAASKAPV-------CQEITVPMCRGIGYNLTHMPNQF 55
           RP  + P  LL LLL    G A    +  +       CQ I++P+C  I YN T MPN  
Sbjct: 2   RPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLL 61

Query: 56  NHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAG 115
            H  Q++AGLEVHQF+PLV++QCSP+LRFFLCSMY P+C     + +PPCRS+CERA+ G
Sbjct: 62  GHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LEQAIPPCRSICERARQG 120

Query: 116 CSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSE------ATTAPPRPFPAKPTL 169
           C  LM ++GF WPER+ C+  P  G  AE +C+  N SE       TTAPP     +P  
Sbjct: 121 CEALMNKFGFQWPERLRCEHFPRHG--AEQICVGQNHSEDGAPALLTTAPPPGL--QPGA 176

Query: 170 PGPPGAPASGGECPAGG----PFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQP 225
            G PG P  GG  P       PF C        +LK   P Y   +     +CA PC +P
Sbjct: 177 GGTPGGPGGGGAPPRYATLEHPFHCP------RVLKV--PSYLSYKFLGERDCAAPC-EP 227

Query: 226 S-------FSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACY 278
           +       FS +E  FA  WI  WSVLC  ST  TV T+L+DM+RFRYPERPIIFLS CY
Sbjct: 228 ARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCY 287

Query: 279 LCVSLGFLVRLVVGHASVACSREHNHIHYET----TGPALCTIVFLLVYFFGMASSIWWV 334
             VS+ ++   V+    V C+   +   Y T    T    CTI+F+++YFF MASSIWWV
Sbjct: 288 TMVSVAYIAGFVL-QERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWV 346

Query: 335 ILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGN 394
           ILSLTWFLAAGMKWG+EAI   +QYFHLAAW +P+VK+IT LA+  +DGD ++G+C+VG 
Sbjct: 347 ILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGL 406

Query: 395 QNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFT 454
            +L+ LRGFVL PL +YL +GT FLLAGFVSLFRIR+++K  GTKT+KLE+LM+RIG+F+
Sbjct: 407 NSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFS 466

Query: 455 LLYTVPASIVVACYLYEQHYRESWE--------AALTCACPGHDTGQPRAKPEYWVLMLK 506
           +LYTVPA+IV+ACY YEQ +RE WE         +L   CP H T  PR  P++ V M+K
Sbjct: 467 VLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYT--PRMSPDFTVYMIK 524

Query: 507 YFMCLVVGITSGVWIWSGKTVESWRRFTSR 536
           Y M L+VGITSG WIWSGKT+ SWR+F +R
Sbjct: 525 YLMTLIVGITSGFWIWSGKTLHSWRKFYTR 554


>gi|4503833 frizzled 7 [Homo sapiens]
          Length = 574

 Score =  535 bits (1379), Expect = e-152
 Identities = 286/582 (49%), Positives = 367/582 (63%), Gaps = 65/582 (11%)

Query: 1   MARPDPSAPPS---LLLLLLAQLVGRAAAASKAPV-------------CQEITVPMCRGI 44
           M  P  +AP S   L  L+LA L   +A A   P              CQ I++P+C  I
Sbjct: 1   MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDI 60

Query: 45  GYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPP 104
            YN T +PN   H  Q++AGLEVHQF+PLV++QCSP+LRFFLCSMY P+C     + +PP
Sbjct: 61  AYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LDQAIPP 119

Query: 105 CRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAP---PR 161
           CRS+CERA+ GC  LM ++GF WPER+ C+  PV G  A  +C+  N S+ +  P   P 
Sbjct: 120 CRSLCERARQGCEALMNKFGFQWPERLRCENFPVHG--AGEICVGQNTSDGSGGPGGGPT 177

Query: 162 PFPAKPTLPG------PPGAPASGGECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQV 215
            +P  P LP       PPGA  S G      PF C  +    P        Y   R    
Sbjct: 178 AYPTAPYLPDLPFTALPPGA--SDGRGRPAFPFSCPRQLKVPP--------YLGYRFLGE 227

Query: 216 PNCAVPCYQPS-------FSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPE 268
            +C  PC +P        F  +ER FA  W+G+WSVLC  ST  TV T+L+DM RF YPE
Sbjct: 228 RDCGAPC-EPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPE 286

Query: 269 RPIIFLSACYLCVSLGFLVRLVVGHASVACSREHNHIHYETTGPAL----CTIVFLLVYF 324
           RPIIFLS CY  V++  +   ++   +V C    +   Y T         CTI+F+++YF
Sbjct: 287 RPIIFLSGCYFMVAVAHVAGFLLEDRAV-CVERFSDDGYRTVAQGTKKEGCTILFMVLYF 345

Query: 325 FGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGD 384
           FGMASSIWWVILSLTWFLAAGMKWG+EAI   +QYFHLAAW +P+VK+IT LA+  VDGD
Sbjct: 346 FGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGD 405

Query: 385 PVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLE 444
            ++G+CYVG  ++++LRGFVL PL +YL +GT FLLAGFVSLFRIR+++K  GTKT+KLE
Sbjct: 406 LLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLE 465

Query: 445 KLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEA----------ALTCACPGHDTGQP 494
           KLM+RIG+F++LYTVPA+IV+ACY YEQ +RE WE           A+ C  PGH    P
Sbjct: 466 KLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCP-PGH---FP 521

Query: 495 RAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSR 536
              P++ V M+KY M ++VGIT+G WIWSGKT++SWRRF  R
Sbjct: 522 PMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHR 563


>gi|4503825 frizzled 1 [Homo sapiens]
          Length = 647

 Score =  520 bits (1339), Expect = e-147
 Identities = 268/534 (50%), Positives = 345/534 (64%), Gaps = 43/534 (8%)

Query: 33  CQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTP 92
           CQ I++P+C  I YN T MPN   H  Q++AGLEVHQF+PLV++QCS +L+FFLCSMY P
Sbjct: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAP 175

Query: 93  ICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNR 152
           +C     + LPPCRS+CERA+ GC  LM ++GF WP+ + C++ PV G  A  LC+  N 
Sbjct: 176 VCTV-LEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHG--AGELCVGQNT 232

Query: 153 SEATTAPPRPFPAKPTLPGPPGAPASGGECPAG------GPFVCKCREPFVPILKESHPL 206
           S+  T  P   P   T     G     G  P G      G F C  R   VP     H L
Sbjct: 233 SDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCP-RALKVPSYLNYHFL 291

Query: 207 YNKVRTGQVPNCAVPCYQPS-------FSADERTFATFWIGLWSVLCFISTSTTVATFLI 259
             K       +C  PC +P+       F  +E  F+  WIG+WSVLC  ST  TV T+L+
Sbjct: 292 GEK-------DCGAPC-EPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLV 343

Query: 260 DMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHNHIHYETTGPAL----C 315
           DM RF YPERPIIFLS CY  V++ ++   ++    V C+ +       T         C
Sbjct: 344 DMRRFSYPERPIIFLSGCYTAVAVAYIAGFLL-EDRVVCNDKFAEDGARTVAQGTKKEGC 402

Query: 316 TIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITA 375
           TI+F+++YFF MASSIWWVILSLTWFLAAGMKWG+EAI   +QYFHLAAW +P++K+IT 
Sbjct: 403 TILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITI 462

Query: 376 LALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQ 435
           LAL  VDGD ++G+C+VG  N+++LRGFVL PL +YL +GT FLLAGFVSLFRIR+++K 
Sbjct: 463 LALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKH 522

Query: 436 GGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWE---AALTC-----ACP 487
            GTKT+KLEKLM+RIG+F++LYTVPA+IV+ACY YEQ +R+ WE    A +C      CP
Sbjct: 523 DGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCP 582

Query: 488 GHDTG-----QPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSR 536
               G      P   P++ V M+KY M L+VGITSG WIWSGKT+ SWR+F +R
Sbjct: 583 HLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTR 636


>gi|6005762 frizzled 10 [Homo sapiens]
          Length = 581

 Score =  486 bits (1252), Expect = e-137
 Identities = 260/582 (44%), Positives = 352/582 (60%), Gaps = 45/582 (7%)

Query: 1   MARPDPSAPPSLLLLLLAQLVGRAAAASKAPV-------CQEITVPMCRGIGYNLTHMPN 53
           M RP P       L L+ Q++G  AA S   +       CQ I +PMC+ IGYN+T MPN
Sbjct: 1   MQRPGPR------LWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPN 54

Query: 54  QFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAK 113
              H+ Q EA +++H+F PLVE  C   LRFFLCS+Y P+C      P+P CR +CE+A+
Sbjct: 55  LMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQAR 114

Query: 114 AGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDY--NRSEATTAPPRPFPAKPTLPG 171
             CSP+M Q+ F WP+ + C +LP    D   LCM+   N S+  T     FP  P    
Sbjct: 115 LKCSPIMEQFNFKWPDSLDCRKLPNKN-DPNYLCMEAPNNGSDEPTRGSGLFP--PLFR- 170

Query: 172 PPGAPASGGECPA--GGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSA 229
            P  P S  E P   GGP    C  P           ++  ++        P     +S 
Sbjct: 171 -PQRPHSAQEHPLKDGGPGRGGCDNP--------GKFHHVEKSASCAPLCTPGVDVYWSR 221

Query: 230 DERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRL 289
           +++ FA  W+ +W+VLCF S++ TV TFLID  RFRYPERPIIFLS CY   S+G+L+RL
Sbjct: 222 EDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRL 281

Query: 290 VVGHASVACSREHNHIHY-----ETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAA 344
             G  S+AC R+   ++      E+TG   CT+VFL++Y+FGMASS+WWV+L+LTWFLAA
Sbjct: 282 FAGAESIACDRDSGQLYVIQEGLESTG---CTLVFLVLYYFGMASSLWWVVLTLTWFLAA 338

Query: 345 GMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFV 404
           G KWG+EAI   + YFHLAAW IP+VK+I  L +  V GD + G+CYVG+ ++N+L GFV
Sbjct: 339 GKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFV 398

Query: 405 LGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIV 464
           L PL  YL++GT F+L+GFV+LF IR V+K GG  TDKLEKLM+RIG+F++LYTVPA+ V
Sbjct: 399 LIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCV 458

Query: 465 VACYLYEQHYRESWE---AALTCACPGH----DTGQPRAKPEYWVLMLKYFMCLVVGITS 517
           +ACY YE+   + W+   A   C         D     + P   + M+K FM LVVGITS
Sbjct: 459 IACYFYERLNMDYWKILAAQHKCKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITS 518

Query: 518 GVWIWSGKTVESWRRFTSRCCCRPRRGHKSGGAMAAGDYPEA 559
           G+WIW+ KT++SW++  SR   +  R   +    + G Y +A
Sbjct: 519 GMWIWTSKTLQSWQQVCSRRLKKKSRRKPASVITSGGIYKKA 560


>gi|4503835 frizzled 9 [Homo sapiens]
          Length = 591

 Score =  477 bits (1228), Expect = e-134
 Identities = 261/573 (45%), Positives = 338/573 (58%), Gaps = 52/573 (9%)

Query: 15  LLLAQLVGRAAAASK-----------APVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEA 63
           LLL QL+    AA +           A  CQ + +PMCRGIGYNLT MPN   H +Q EA
Sbjct: 10  LLLWQLLAAGGAALEIGRFDPERGRGAAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEA 69

Query: 64  GLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQY 123
             E+ +F PLV+  C   LRFFLCS+Y P+C      P+P CR +CE+A+  C+P+M Q+
Sbjct: 70  AAELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQF 129

Query: 124 GFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRP------FPAKPTLPGPPGAPA 177
            F WP+ + C RLP    D   LCM+   + AT  P  P       P  P    PPG   
Sbjct: 130 NFGWPDSLDCARLPTRN-DPHALCMEAPEN-ATAGPAEPHKGLGMLPVAPRPARPPGDLG 187

Query: 178 SGGECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSADERTFATF 237
            G    AGG   C+  E F  + K              P C  P  +  +S  ++ FA  
Sbjct: 188 PG----AGGSGTCENPEKFQYVEKSR---------SCAPRCG-PGVEVFWSRRDKDFALV 233

Query: 238 WIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVA 297
           W+ +WS LCF ST+ TV TFL++  RF+YPERPIIFLS CY   SL FL+R V G  SVA
Sbjct: 234 WMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVA 293

Query: 298 CSREHNHIHY-----ETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEA 352
           C +E   ++      E TG   CT+VFLL+Y+FGMASS+WWV+L+LTWFLAAG KWG+EA
Sbjct: 294 CDQEAGALYVIQEGLENTG---CTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEA 350

Query: 353 IAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYL 412
           I  +  YFH+AAW +P++K+I  L L  V GD + G+CYV + +  +L GFVL PL  YL
Sbjct: 351 IEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYL 410

Query: 413 LVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQ 472
           ++G+ FLL GFV+LF IR ++K GGT T+KLEKLM++IG+F++LYTVPA+ V+ CY+YE+
Sbjct: 411 VLGSSFLLTGFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYER 470

Query: 473 HYRESWEAALT---CAC---PG--HDTGQPRAK-PEYWVLMLKYFMCLVVGITSGVWIWS 523
              + W    T   CA    PG   D   P    P   V MLK FM LVVGITSGVW+WS
Sbjct: 471 LNMDFWRLRATEQPCAAAAGPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWS 530

Query: 524 GKTVESWRRFTSRCCCRPRRGHKSGGAMAAGDY 556
            KT ++W+    R     R   K+    A G Y
Sbjct: 531 SKTFQTWQSLCYRKIAAGRARAKA--CRAPGSY 561


>gi|22547161 frizzled 4 [Homo sapiens]
          Length = 537

 Score =  439 bits (1129), Expect = e-123
 Identities = 237/549 (43%), Positives = 326/549 (59%), Gaps = 67/549 (12%)

Query: 6   PSAPPSL-----LLLLLAQLVG--RAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHD 58
           P AP  +     LLL L  L+G  R     +   C  I + MC+ +GYN+T MPN   H+
Sbjct: 11  PGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHE 70

Query: 59  TQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSP 118
            Q +A L++  F PL++  CS  L+FFLCS+Y P+C    + P+ PC  +C   K  C P
Sbjct: 71  LQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEP 130

Query: 119 LMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPAS 178
           +++++GFAWPE ++C + P    D   +CM+    E    P +  P +P           
Sbjct: 131 VLKEFGFAWPESLNCSKFPP-QNDHNHMCMEGPGDEEVPLPHKT-PIQP----------- 177

Query: 179 GGECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPS--FSADERTFAT 236
           G EC + G                +   Y  V+     NC + C   +  +S   + F  
Sbjct: 178 GEECHSVG---------------TNSDQYIWVKRSL--NCVLKCGYDAGLYSRSAKEFTD 220

Query: 237 FWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASV 296
            W+ +W+ LCFIST+ TV TFLID  RF YPERPIIFLS CY   S+ ++VRL VG   +
Sbjct: 221 IWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERI 280

Query: 297 ACSREHNHIHYETTGPAL---------CTIVFLLVYFFGMASSIWWVILSLTWFLAAGMK 347
           +C  E      E   P L         C I+FLL+YFFGMASSIWWVIL+LTWFLAAG+K
Sbjct: 281 SCDFE------EAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLK 334

Query: 348 WGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGP 407
           WG+EAI  ++ YFH+AAW IP+VK+I  L +  VD D + G+CYVGNQNL++L GFV+ P
Sbjct: 335 WGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAP 394

Query: 408 LVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVAC 467
           L  YL++GTLF+ AG V+LF+IRS +++ GTKTDKLE+LM++IG+F++LYTVPA+ V+AC
Sbjct: 395 LFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIAC 454

Query: 468 YLYEQHYRESWEAALTCACPGHDTGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTV 527
           Y YE     +W      A   +            V MLK FM L+VGITSG+WIWS KT+
Sbjct: 455 YFYE---ISNWALFRYSADDSNMA----------VEMLKIFMSLLVGITSGMWIWSAKTL 501

Query: 528 ESWRRFTSR 536
            +W++ ++R
Sbjct: 502 HTWQKCSNR 510


>gi|8393378 frizzled 3 [Homo sapiens]
          Length = 666

 Score =  366 bits (939), Expect = e-101
 Identities = 211/516 (40%), Positives = 286/516 (55%), Gaps = 48/516 (9%)

Query: 33  CQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTP 92
           C+ IT+ MC+ + YN T MPN  NH  Q  A L +  F P+V + CS D R FLC++Y P
Sbjct: 28  CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAP 87

Query: 93  ICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNR 152
           IC+ +Y +   PCR +C+RA + CS LM  +G  WPE M C R P    D +        
Sbjct: 88  ICM-EYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFP----DCD-------- 134

Query: 153 SEATTAPPRPFPAKPTLPGPP--GAPASGGECPAGGPFVCKCREPFVPILKESHPLYNKV 210
                  P P      L G P  GAP +         F C       P L  S       
Sbjct: 135 ------EPYPRLVDLNLAGEPTEGAPVA---VQRDYGFWCPRELKIDPDLGYSFL----- 180

Query: 211 RTGQVPNCAVPCYQPSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERP 270
               V +C+ PC    F  +E +FA ++IGL S++C  +T  T  TFLID+ RFRYPERP
Sbjct: 181 ---HVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERP 237

Query: 271 IIFLSACYLCVSL----GFLVR-LVVGHASVACSREHNHIHYETTGPALCTIVFLLVYFF 325
           IIF + CY+ VSL    GFL+   V  +AS+    + + +   +   A CT++F+++YFF
Sbjct: 238 IIFYAVCYMMVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKA-CTMLFMILYFF 296

Query: 326 GMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDP 385
            MA S+WWVIL++TWFLAA  KWG+EAI   A  FH +AW IP   +I  LA++ ++GD 
Sbjct: 297 TMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDN 356

Query: 386 VAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEK 445
           ++G+C+VG  ++++LR FVL PL LY++VG   LLAG +SL R+R  I       DKL K
Sbjct: 357 ISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVK 416

Query: 446 LMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAA--------LTCACPGHDTGQPRAK 497
            MIRIG+F++LY VP  +V+ CY YEQ YR  WE              CP   T   R  
Sbjct: 417 FMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSR-- 474

Query: 498 PEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRF 533
           P+  + ++KY M L+VGI S  W+ S KT   W  F
Sbjct: 475 PDLILFLMKYLMALIVGIPSVFWVGSKKTCFEWASF 510


>gi|34734079 frizzled 6 [Homo sapiens]
          Length = 706

 Score =  353 bits (905), Expect = 3e-97
 Identities = 199/525 (37%), Positives = 275/525 (52%), Gaps = 60/525 (11%)

Query: 33  CQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTP 92
           C+ ITVP C  + YN+T  PN   H  Q  A +E+  F PL  ++CSP++  FLC  + P
Sbjct: 24  CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVP 83

Query: 93  ICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNR 152
            C+   H  +PPCR +CE+  + C  L+  +G  WPE + CDRL        V       
Sbjct: 84  TCIEQIHV-VPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPV------- 135

Query: 153 SEATTAPPRPF--PAKPTLPGPPGAPASGGECPAGGPFVCKCREPFVPILKESHPLYNKV 210
              T  P   F  P K T            +      F C              P + K 
Sbjct: 136 ---TFDPHTEFLGPQKKT-----------EQVQRDIGFWC--------------PRHLKT 167

Query: 211 RTGQ------VPNCAVPCYQPSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERF 264
             GQ      +  CA PC    F +DE  FA  +IG  S+ C  +T  T  TFLID+ RF
Sbjct: 168 SGGQGYKFLGIDQCAPPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRF 227

Query: 265 RYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHNHIHYETT-----GPALCTIVF 319
           RYPERPII+ S CY  VSL + +  ++G  S AC++    +    T         CT++F
Sbjct: 228 RYPERPIIYYSVCYSIVSLMYFIGFLLGD-STACNKADEKLELGDTVVLGSQNKACTVLF 286

Query: 320 LLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALS 379
           +L+YFF MA ++WWVIL++TWFLAAG KW  EAI   A +FH  AW  P   ++  LA++
Sbjct: 287 MLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMN 346

Query: 380 SVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTK 439
            V+GD ++G+C+VG  +L++ R FVL PL L + VG   LLAG +SL  +R VI+  G  
Sbjct: 347 KVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRN 406

Query: 440 TDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAALT--------CACPGHDT 491
            +KL+K MIRIG+F+ LY VP   ++ CY+YEQ  R +WE              CP    
Sbjct: 407 QEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQ-- 464

Query: 492 GQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSR 536
            + +A+PE  + M+KY M L+VGI++  W+ S KT   W  F  R
Sbjct: 465 AKAKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKR 509


>gi|5032099 smoothened [Homo sapiens]
          Length = 787

 Score =  183 bits (464), Expect = 4e-46
 Identities = 151/552 (27%), Positives = 251/552 (45%), Gaps = 84/552 (15%)

Query: 29  KAPVCQEITVPMCRG--IGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEI-QCSPDLRFF 85
           +A  C+ +   +C G  + Y  T      + D+Q+EA  ++  +  L    +C   ++  
Sbjct: 66  RAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPL 125

Query: 86  LCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSC--DRLPVLGRDA 143
           LC++Y P C  D  +   P R++C+  +  C+ + R+ G  WP+ + C  DR P  G   
Sbjct: 126 LCAVYMPKCEND--RVELPSRTLCQATRGPCAIVERERG--WPDFLRCTPDRFPE-GCTN 180

Query: 144 EVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPASGGECPAGGPFVCKCREPFVPILKES 203
           EV  + +N                          S G+C              VP+++  
Sbjct: 181 EVQNIKFN--------------------------SSGQCE-------------VPLVRTD 201

Query: 204 HPLYNKVRTGQVPNCAVPCYQPSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMER 263
           +P   K     V  C + C  P F+  E      +I  +  +  + T  T+ATF+ D   
Sbjct: 202 NP---KSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRN 258

Query: 264 F-RYPERPIIFLSACYLCVSLGFLVRLVVG-HASVACSREHN-HIHYETTGPAL-CTIVF 319
             RYP   + +++AC+   S+G+L + + G    + C  +    +   T+   L C I+F
Sbjct: 259 SNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIF 318

Query: 320 LLVYFFGMASSIWWVILSLTW---FLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITAL 376
           ++VY+  MA  +W+V+L+  W   F A G  +  + ++G   YFHL  W +P V ++  L
Sbjct: 319 VIVYYALMAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAIL 376

Query: 377 ALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQG 436
           A++ VDGD V+GIC+VG +N     GFVL P+ L L+VG  FL+ G ++LF I+S     
Sbjct: 377 AVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--NHP 434

Query: 437 GTKTD----KLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAA----LTCACP- 487
           G  ++    K+ + M+R+GIF  L      I  +C+ Y+   +  WE +    + C    
Sbjct: 435 GLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANV 494

Query: 488 --GHDTGQP------RAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWR----RFTS 535
             G  T QP      + +P   V  +  F     GI    W+W+  T+  WR    R T 
Sbjct: 495 TIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTG 554

Query: 536 RCCCRPRRGHKS 547
           +    P+R  KS
Sbjct: 555 QSDDEPKRIKKS 566


>gi|38455388 frizzled-related protein [Homo sapiens]
          Length = 325

 Score =  140 bits (354), Expect = 2e-33
 Identities = 73/191 (38%), Positives = 106/191 (55%), Gaps = 22/191 (11%)

Query: 10  PSLLLLLLAQLVGRAAAA------SKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEA 63
           P  +LLL A L+  AA        ++A  C+ + +P+C+ + +N+T MPN  +H TQ  A
Sbjct: 6   PGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANA 65

Query: 64  GLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDY-HKPLPPCRSVCERAKAGCSPLMRQ 122
            L + QF  L+   CSPDL FFLC+MY PIC  D+ H+P+ PC+SVCERA+ GC P++ +
Sbjct: 66  ILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIK 125

Query: 123 YGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPASGGEC 182
           Y  +WPE ++C+ LPV  R    +C+  +     TA    FP            +S G C
Sbjct: 126 YRHSWPENLACEELPVYDRG---VCI--SPEAIVTADGADFP----------MDSSNGNC 170

Query: 183 PAGGPFVCKCR 193
                  CKC+
Sbjct: 171 RGASSERCKCK 181


>gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]
          Length = 346

 Score =  133 bits (334), Expect = 5e-31
 Identities = 59/130 (45%), Positives = 85/130 (65%), Gaps = 2/130 (1%)

Query: 13  LLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWP 72
           +L+ L   +  A     AP C+ + +PMCR + +N+T MPN  +H TQ+ A L + Q+  
Sbjct: 5   ILVALCLWLHLALGVRGAP-CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEE 63

Query: 73  LVEIQCSPDLRFFLCSMYTPICLPDY-HKPLPPCRSVCERAKAGCSPLMRQYGFAWPERM 131
           LV++ CS  LRFFLC+MY PIC  ++ H P+ PC+SVC+RA+  C PLM+ Y  +WPE +
Sbjct: 64  LVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESL 123

Query: 132 SCDRLPVLGR 141
           +CD LPV  R
Sbjct: 124 ACDELPVYDR 133


>gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]
          Length = 317

 Score =  105 bits (263), Expect = 9e-23
 Identities = 45/113 (39%), Positives = 68/113 (60%), Gaps = 5/113 (4%)

Query: 28  SKAPVCQEIT--VPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFF 85
           SK P C +I   +P+C  +GY    +PN   H++  E   +   + PL+  +C  D + F
Sbjct: 48  SKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVF 107

Query: 86  LCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPV 138
           LCS++ P+CL    +P+ PCRS+CE  +AGC+PLM  YGF WPE + C + P+
Sbjct: 108 LCSLFAPVCLD---RPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPL 157


>gi|48475052 secreted frizzled-related protein 2 precursor [Homo
           sapiens]
          Length = 295

 Score =  105 bits (261), Expect = 2e-22
 Identities = 53/142 (37%), Positives = 75/142 (52%), Gaps = 13/142 (9%)

Query: 9   PPSLLLLLLAQ-----------LVGRAAAASKAPVCQEI--TVPMCRGIGYNLTHMPNQF 55
           P SLLLL LA            L G+   + K   C+ I   + +C GI Y    +PN  
Sbjct: 5   PGSLLLLFLASHCCLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNLL 64

Query: 56  NHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAG 115
            H+T  E   +   + PLV  QC PD + FLCS++ P+CL D  + + PC S+C + K  
Sbjct: 65  GHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQVKDR 124

Query: 116 CSPLMRQYGFAWPERMSCDRLP 137
           C+P+M  +GF WP+ + CDR P
Sbjct: 125 CAPVMSAFGFPWPDMLECDRFP 146


>gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]
          Length = 314

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 39/112 (34%), Positives = 61/112 (54%), Gaps = 5/112 (4%)

Query: 28  SKAPVCQEITVPM--CRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFF 85
           +K P C +I   +  C  +GY    +PN   H+T  E   +   + PL+   C    + F
Sbjct: 53  TKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVF 112

Query: 86  LCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLP 137
           LCS++ P+CL    +P+ PCR +CE  +  C P+M+ +GF WPE + CD+ P
Sbjct: 113 LCSLFAPVCLD---RPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFP 161


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 42/118 (35%), Positives = 60/118 (50%), Gaps = 2/118 (1%)

Query: 33  CQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGL--EVHQFWPLVEIQCSPDLRFFLCSMY 90
           C+ IT+ +C  + YN T  PN F H TQ EA +  E   F  LV+  C   L FF C++ 
Sbjct: 455 CEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTIL 514

Query: 91  TPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCM 148
            P C  +  + +PPCR++CE +K  C  ++   G  WPE   C + P    D +   M
Sbjct: 515 VPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLM 572



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 30/106 (28%), Positives = 49/106 (46%), Gaps = 5/106 (4%)

Query: 33  CQEITVPMCRGIGYNLTHMPN-QFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYT 91
           C  IT   C+ + Y+ T  P      + + E  L+   +  L  + C   +  F C++  
Sbjct: 139 CMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFFTY--LHRLSCYQHIMLFGCTLAF 196

Query: 92  PICLPDYHKP--LPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDR 135
           P C+ D      L PCRS CE AK GC  ++    ++WP+ + C +
Sbjct: 197 PECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQ 242


>gi|13899255 membrane frizzled-related protein [Homo sapiens]
          Length = 579

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 38/106 (35%), Positives = 52/106 (49%), Gaps = 4/106 (3%)

Query: 33  CQEITVPMCRGIGYNLTHMPNQF-NHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYT 91
           C+ + V MC G+ YN T  PN +    TQ+E    +  +  L  + C    R  LC +  
Sbjct: 466 CEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLV 525

Query: 92  PICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLP 137
           P C P     LPPCRSVC+ A+  C   +   G  WP   +C+RLP
Sbjct: 526 PRCTP-LGSVLPPCRSVCQEAEHQCQSGLALLGTPWP--FNCNRLP 568


>gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]
          Length = 641

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 45/141 (31%), Positives = 62/141 (43%), Gaps = 16/141 (11%)

Query: 6   PSAPPSLLLLLLAQLVGRAAAA---SKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQD- 61
           P  PP LLL +L     R       + A  C ++ +  C    YN T  PN   H + + 
Sbjct: 2   PPPPPLLLLTVLVVAAARPGCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEV 61

Query: 62  -EAGLE------VHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKA 114
            EA  E      +HQ   L+E QC+PDLR   C++  P C   + +   PCR +CE  + 
Sbjct: 62  VEASSEYILLSVLHQ---LLEGQCNPDLRLLGCAVLAPRCEGGWVR--RPCRHICEGLRE 116

Query: 115 GCSPLMRQYGFAWPERMSCDR 135
            C P       AWP  + C R
Sbjct: 117 VCQPAFDAIDMAWPYFLDCHR 137


>gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]
          Length = 652

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 45/152 (29%), Positives = 63/152 (41%), Gaps = 27/152 (17%)

Query: 6   PSAPPSLLLLLLAQLVGRAAA--------------ASKAPVCQEITVPMCRGIGYNLTHM 51
           P  PP LLL +L     R                 A+ +  C ++ +  C    YN T  
Sbjct: 2   PPPPPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTTF 61

Query: 52  PNQFNHDTQD--EAGLE------VHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLP 103
           PN   H + +  EA  E      +HQ   L+E QC+PDLR   C++  P C   + +   
Sbjct: 62  PNLLQHRSWEVVEASSEYILLSVLHQ---LLEGQCNPDLRLLGCAVLAPRCEGGWVRR-- 116

Query: 104 PCRSVCERAKAGCSPLMRQYGFAWPERMSCDR 135
           PCR +CE  +  C P       AWP  + C R
Sbjct: 117 PCRHICEGLREVCQPAFDAIDMAWPYFLDCHR 148


>gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Homo
           sapiens]
          Length = 1751

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 26/102 (25%), Positives = 44/102 (43%), Gaps = 11/102 (10%)

Query: 37  TVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLP 96
           ++P+C  +G +   +PN  +H++ ++       +  L++  C P L +F C +  P C  
Sbjct: 340 SLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLAWFFCLLLVPPCGS 399

Query: 97  DYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPV 138
                 PPC   CE  +  C          W  R+   RLPV
Sbjct: 400 VPPPAPPPCCQFCEALQDAC----------W-SRLGGGRLPV 430


>gi|119943125 G protein-coupled receptor 64 isoform 3 [Homo sapiens]
          Length = 995

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 53/225 (23%), Positives = 91/225 (40%), Gaps = 33/225 (14%)

Query: 245 LCFISTSTTVATFLIDMERFR--YPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREH 302
           L  I  S T+ T+ I  E+ R  YP + +I L A  L ++L FL+   +           
Sbjct: 616 LSSIFLSVTLVTY-IAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSWIAL--------- 665

Query: 303 NHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHL 362
               Y+  G  LC  V + +++F + S  W  + +   +LA  +K  N  I  Y   F +
Sbjct: 666 ----YKMQG--LCISVAVFLHYFLLVSFTWMGLEAFHMYLAL-VKVFNTYIRKYILKFCI 718

Query: 363 AAWLIPSVKSITALALSS-----------VDGDPVAGICYVGNQNLNSLRGFVLGPLVLY 411
             W +P+V     L +S             +G P    C++ N  +  +   V+G   + 
Sbjct: 719 VGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSP-DDFCWINNNAVFYIT--VVGYFCVI 775

Query: 412 LLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLL 456
            L+     +   V L RI+   + G  +   ++ L    G+  LL
Sbjct: 776 FLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLL 820


>gi|119943116 G protein-coupled receptor 64 isoform 2 [Homo sapiens]
          Length = 1003

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 53/225 (23%), Positives = 91/225 (40%), Gaps = 33/225 (14%)

Query: 245 LCFISTSTTVATFLIDMERFR--YPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREH 302
           L  I  S T+ T+ I  E+ R  YP + +I L A  L ++L FL+   +           
Sbjct: 624 LSSIFLSVTLVTY-IAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSWIAL--------- 673

Query: 303 NHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHL 362
               Y+  G  LC  V + +++F + S  W  + +   +LA  +K  N  I  Y   F +
Sbjct: 674 ----YKMQG--LCISVAVFLHYFLLVSFTWMGLEAFHMYLAL-VKVFNTYIRKYILKFCI 726

Query: 363 AAWLIPSVKSITALALSS-----------VDGDPVAGICYVGNQNLNSLRGFVLGPLVLY 411
             W +P+V     L +S             +G P    C++ N  +  +   V+G   + 
Sbjct: 727 VGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSP-DDFCWINNNAVFYIT--VVGYFCVI 783

Query: 412 LLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLL 456
            L+     +   V L RI+   + G  +   ++ L    G+  LL
Sbjct: 784 FLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLL 828


>gi|119943120 G protein-coupled receptor 64 isoform 1 [Homo sapiens]
          Length = 1017

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 53/225 (23%), Positives = 91/225 (40%), Gaps = 33/225 (14%)

Query: 245 LCFISTSTTVATFLIDMERFR--YPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREH 302
           L  I  S T+ T+ I  E+ R  YP + +I L A  L ++L FL+   +           
Sbjct: 638 LSSIFLSVTLVTY-IAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSWIAL--------- 687

Query: 303 NHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHL 362
               Y+  G  LC  V + +++F + S  W  + +   +LA  +K  N  I  Y   F +
Sbjct: 688 ----YKMQG--LCISVAVFLHYFLLVSFTWMGLEAFHMYLAL-VKVFNTYIRKYILKFCI 740

Query: 363 AAWLIPSVKSITALALSS-----------VDGDPVAGICYVGNQNLNSLRGFVLGPLVLY 411
             W +P+V     L +S             +G P    C++ N  +  +   V+G   + 
Sbjct: 741 VGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSP-DDFCWINNNAVFYIT--VVGYFCVI 797

Query: 412 LLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLL 456
            L+     +   V L RI+   + G  +   ++ L    G+  LL
Sbjct: 798 FLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLL 842


>gi|119943129 G protein-coupled receptor 64 isoform 4 [Homo sapiens]
          Length = 1014

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 53/225 (23%), Positives = 91/225 (40%), Gaps = 33/225 (14%)

Query: 245 LCFISTSTTVATFLIDMERFR--YPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREH 302
           L  I  S T+ T+ I  E+ R  YP + +I L A  L ++L FL+   +           
Sbjct: 635 LSSIFLSVTLVTY-IAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSWIAL--------- 684

Query: 303 NHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHL 362
               Y+  G  LC  V + +++F + S  W  + +   +LA  +K  N  I  Y   F +
Sbjct: 685 ----YKMQG--LCISVAVFLHYFLLVSFTWMGLEAFHMYLAL-VKVFNTYIRKYILKFCI 737

Query: 363 AAWLIPSVKSITALALSS-----------VDGDPVAGICYVGNQNLNSLRGFVLGPLVLY 411
             W +P+V     L +S             +G P    C++ N  +  +   V+G   + 
Sbjct: 738 VGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSP-DDFCWINNNAVFYIT--VVGYFCVI 794

Query: 412 LLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLL 456
            L+     +   V L RI+   + G  +   ++ L    G+  LL
Sbjct: 795 FLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLL 839


>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
            sapiens]
          Length = 3312

 Score = 38.5 bits (88), Expect = 0.017
 Identities = 40/157 (25%), Positives = 67/157 (42%), Gaps = 14/157 (8%)

Query: 307  YETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWL 366
            + T    +CT V +L+++F +++  W  +  L   L            G  +++H   W 
Sbjct: 2594 HRTHNQLVCTAVAILLHYFFLSTFAWLFVQGL--HLYRMQVEPRNVDRGAMRFYHALGWG 2651

Query: 367  IPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLV-GTLFLLAGFVS 425
            +P+V    A+ L   +G      C++       L     GP+VL +++ GT+FLLA    
Sbjct: 2652 VPAVLLGLAVGLDP-EGYGNPDFCWISVH--EPLIWSFAGPVVLVIVMNGTMFLLAA--- 2705

Query: 426  LFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPAS 462
                R+    G  +  K   L +R   F LL  V AS
Sbjct: 2706 ----RTSCSTGQREAKKTSALTLR-SSFLLLLLVSAS 2737


>gi|74048357 G protein-coupled receptor 126 alpha 1 precursor [Homo
            sapiens]
          Length = 1221

 Score = 38.1 bits (87), Expect = 0.023
 Identities = 42/185 (22%), Positives = 85/185 (45%), Gaps = 23/185 (12%)

Query: 246  CFISTSTTVATFL--IDMERFR--YPERPIIFLSACYLCVSLGFLVRLVVGHASVACSRE 301
            C IS   + AT L  +  E+ R  YP + ++ LS   L ++L FL+   +   +V     
Sbjct: 872  CGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLLFLLDGWITSFNV----- 926

Query: 302  HNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFH 361
                        LC  V +L++FF +A+  W  + ++  ++A  +K  N  I  Y   F 
Sbjct: 927  ----------DGLCIAVAVLLHFFLLATFTWMGLEAIHMYIAL-VKVFNTYIRRYILKFC 975

Query: 362  LAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLA 421
            +  W +P++  + ++ L+S + + V G    G +  +    ++  P++ Y+     F + 
Sbjct: 976  IIGWGLPAL--VVSVVLASRNNNEVYGKESYGKEKGDEF-CWIQDPVIFYVTCAGYFGVM 1032

Query: 422  GFVSL 426
             F+++
Sbjct: 1033 FFLNI 1037


>gi|50355941 G protein-coupled receptor 126 beta 1 precursor [Homo
            sapiens]
          Length = 1250

 Score = 38.1 bits (87), Expect = 0.023
 Identities = 42/185 (22%), Positives = 85/185 (45%), Gaps = 23/185 (12%)

Query: 246  CFISTSTTVATFL--IDMERFR--YPERPIIFLSACYLCVSLGFLVRLVVGHASVACSRE 301
            C IS   + AT L  +  E+ R  YP + ++ LS   L ++L FL+   +   +V     
Sbjct: 872  CGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLLFLLDGWITSFNV----- 926

Query: 302  HNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFH 361
                        LC  V +L++FF +A+  W  + ++  ++A  +K  N  I  Y   F 
Sbjct: 927  ----------DGLCIAVAVLLHFFLLATFTWMGLEAIHMYIAL-VKVFNTYIRRYILKFC 975

Query: 362  LAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLA 421
            +  W +P++  + ++ L+S + + V G    G +  +    ++  P++ Y+     F + 
Sbjct: 976  IIGWGLPAL--VVSVVLASRNNNEVYGKESYGKEKGDEF-CWIQDPVIFYVTCAGYFGVM 1032

Query: 422  GFVSL 426
             F+++
Sbjct: 1033 FFLNI 1037


>gi|74048422 G protein-coupled receptor 126 alpha 2 precursor [Homo
            sapiens]
          Length = 1193

 Score = 38.1 bits (87), Expect = 0.023
 Identities = 42/185 (22%), Positives = 85/185 (45%), Gaps = 23/185 (12%)

Query: 246  CFISTSTTVATFL--IDMERFR--YPERPIIFLSACYLCVSLGFLVRLVVGHASVACSRE 301
            C IS   + AT L  +  E+ R  YP + ++ LS   L ++L FL+   +   +V     
Sbjct: 844  CGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLLFLLDGWITSFNV----- 898

Query: 302  HNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFH 361
                        LC  V +L++FF +A+  W  + ++  ++A  +K  N  I  Y   F 
Sbjct: 899  ----------DGLCIAVAVLLHFFLLATFTWMGLEAIHMYIAL-VKVFNTYIRRYILKFC 947

Query: 362  LAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLA 421
            +  W +P++  + ++ L+S + + V G    G +  +    ++  P++ Y+     F + 
Sbjct: 948  IIGWGLPAL--VVSVVLASRNNNEVYGKESYGKEKGDEF-CWIQDPVIFYVTCAGYFGVM 1004

Query: 422  GFVSL 426
             F+++
Sbjct: 1005 FFLNI 1009


>gi|74048403 G protein-coupled receptor 126 beta 2 precursor [Homo
            sapiens]
          Length = 1222

 Score = 38.1 bits (87), Expect = 0.023
 Identities = 42/185 (22%), Positives = 85/185 (45%), Gaps = 23/185 (12%)

Query: 246  CFISTSTTVATFL--IDMERFR--YPERPIIFLSACYLCVSLGFLVRLVVGHASVACSRE 301
            C IS   + AT L  +  E+ R  YP + ++ LS   L ++L FL+   +   +V     
Sbjct: 844  CGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLLFLLDGWITSFNV----- 898

Query: 302  HNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFH 361
                        LC  V +L++FF +A+  W  + ++  ++A  +K  N  I  Y   F 
Sbjct: 899  ----------DGLCIAVAVLLHFFLLATFTWMGLEAIHMYIAL-VKVFNTYIRRYILKFC 947

Query: 362  LAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLA 421
            +  W +P++  + ++ L+S + + V G    G +  +    ++  P++ Y+     F + 
Sbjct: 948  IIGWGLPAL--VVSVVLASRNNNEVYGKESYGKEKGDEF-CWIQDPVIFYVTCAGYFGVM 1004

Query: 422  GFVSL 426
             F+++
Sbjct: 1005 FFLNI 1009


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.139    0.467 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,801,140
Number of Sequences: 37866
Number of extensions: 1388583
Number of successful extensions: 12648
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 117
Number of HSP's that attempted gapping in prelim test: 11317
Number of HSP's gapped (non-prelim): 1326
length of query: 585
length of database: 18,247,518
effective HSP length: 108
effective length of query: 477
effective length of database: 14,157,990
effective search space: 6753361230
effective search space used: 6753361230
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.