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Search of human proteins with 27437027
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27437027 calcium/calmodulin-dependent protein kinase kinase
2 beta isoform 2 [Homo sapiens]
(541 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2... 1092 0.0
gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2... 1092 0.0
gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2... 1048 0.0
gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2... 1048 0.0
gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2... 983 0.0
gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2... 939 0.0
gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2... 939 0.0
gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha ... 595 e-170
gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha ... 595 e-170
gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha... 566 e-161
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 156 5e-38
gi|116256471 SNF1-like kinase [Homo sapiens] 156 5e-38
gi|156105707 SNF related kinase [Homo sapiens] 150 2e-36
gi|156105705 SNF related kinase [Homo sapiens] 150 2e-36
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 150 4e-36
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 149 5e-36
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 149 6e-36
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 148 1e-35
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 148 1e-35
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 148 1e-35
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 148 1e-35
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 148 1e-35
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 148 1e-35
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 147 2e-35
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 147 2e-35
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 147 2e-35
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 147 2e-35
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 147 2e-35
gi|4507271 serine/threonine protein kinase 11 [Homo sapiens] 146 4e-35
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 146 5e-35
>gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 2 [Homo sapiens]
Length = 541
Score = 1092 bits (2824), Expect = 0.0
Identities = 541/541 (100%), Positives = 541/541 (100%)
Query: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
Query: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
Query: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
Query: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEEVL 540
LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEEVL
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEEVL 540
Query: 541 L 541
L
Sbjct: 541 L 541
>gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 2 [Homo sapiens]
Length = 541
Score = 1092 bits (2824), Expect = 0.0
Identities = 541/541 (100%), Positives = 541/541 (100%)
Query: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
Query: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
Query: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
Query: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEEVL 540
LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEEVL
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEEVL 540
Query: 541 L 541
L
Sbjct: 541 L 541
>gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 1 [Homo sapiens]
Length = 588
Score = 1048 bits (2710), Expect = 0.0
Identities = 519/524 (99%), Positives = 522/524 (99%)
Query: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
Query: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
Query: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
Query: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSED 524
LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTK+ + +
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRE 524
>gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 5 [Homo sapiens]
Length = 533
Score = 1048 bits (2710), Expect = 0.0
Identities = 519/524 (99%), Positives = 522/524 (99%)
Query: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
Query: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
Query: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
Query: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSED 524
LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTK+ + +
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRE 524
>gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 4 [Homo sapiens]
Length = 498
Score = 983 bits (2540), Expect = 0.0
Identities = 498/541 (92%), Positives = 498/541 (92%), Gaps = 43/541 (7%)
Query: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
Query: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
Query: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
DLITRMLDKNPESRIVVPEIK
Sbjct: 421 DLITRMLDKNPESRIVVPEIK--------------------------------------- 441
Query: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEEVL 540
ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEEVL
Sbjct: 442 ----ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEEVL 497
Query: 541 L 541
L
Sbjct: 498 L 498
>gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 3 [Homo sapiens]
Length = 545
Score = 939 bits (2426), Expect = 0.0
Identities = 476/524 (90%), Positives = 479/524 (91%), Gaps = 43/524 (8%)
Query: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
Query: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
Query: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
DLITRMLDKNPESRIVVPEIK
Sbjct: 421 DLITRMLDKNPESRIVVPEIK--------------------------------------- 441
Query: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSED 524
ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTK+ + +
Sbjct: 442 ----ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRE 481
>gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 6 [Homo sapiens]
Length = 490
Score = 939 bits (2426), Expect = 0.0
Identities = 476/524 (90%), Positives = 479/524 (91%), Gaps = 43/524 (8%)
Query: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
Query: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
Query: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
DLITRMLDKNPESRIVVPEIK
Sbjct: 421 DLITRMLDKNPESRIVVPEIK--------------------------------------- 441
Query: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSED 524
ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTK+ + +
Sbjct: 442 ----ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRE 481
>gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha
isoform a [Homo sapiens]
Length = 505
Score = 595 bits (1534), Expect = e-170
Identities = 294/450 (65%), Positives = 371/450 (82%), Gaps = 12/450 (2%)
Query: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
Query: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
Query: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
Query: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329
+ +GPVMEVP KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Query: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389
DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
Query: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 449
F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++
Sbjct: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
Query: 450 GAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREER 508
G EPLPSE+E+C++VEVTEEEV+NSV+ IPS TVILVK+M+RKRSFGNPFE +RREER
Sbjct: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
Query: 509 SLSAPGNLLTKQGSEDNLQGTDPPPVGEEE 538
S+SAPGNLL K+G + + + P V E+E
Sbjct: 473 SMSAPGNLLVKEGFGEGGKSPELPGVQEDE 502
>gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha
isoform a [Homo sapiens]
Length = 505
Score = 595 bits (1534), Expect = e-170
Identities = 294/450 (65%), Positives = 371/450 (82%), Gaps = 12/450 (2%)
Query: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
Query: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
Query: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
Query: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329
+ +GPVMEVP KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Query: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389
DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
Query: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 449
F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++
Sbjct: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
Query: 450 GAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREER 508
G EPLPSE+E+C++VEVTEEEV+NSV+ IPS TVILVK+M+RKRSFGNPFE +RREER
Sbjct: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
Query: 509 SLSAPGNLLTKQGSEDNLQGTDPPPVGEEE 538
S+SAPGNLL K+G + + + P V E+E
Sbjct: 473 SMSAPGNLLVKEGFGEGGKSPELPGVQEDE 502
>gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha
isoform b [Homo sapiens]
Length = 520
Score = 567 bits (1460), Expect = e-161
Identities = 288/467 (61%), Positives = 360/467 (77%), Gaps = 50/467 (10%)
Query: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
Query: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
Query: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYM---- 265
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+
Sbjct: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQN 232
Query: 266 ----------------------------------VFELVNQGPVMEVPTLKPLSEDQARF 291
VF+L+ +GPVMEVP KP SE+QAR
Sbjct: 233 QAQNIQLDSTNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARL 292
Query: 292 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 351
Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIADFGVSN+F+G+DA LS+T GTP
Sbjct: 293 YLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP 352
Query: 352 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPD 411
AFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CPF+D+ I+ LH KIK++ + FP+
Sbjct: 353 AFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPE 412
Query: 412 QPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEV 471
+P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++G EPLPSE+E+C++VEVTEEEV
Sbjct: 413 EPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEV 472
Query: 472 ENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREERSLSAPGNLL 517
+NSV+ IPS TVILVK+M+RKRSFGNPFE +RREERS+SAPGNLL
Sbjct: 473 KNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLL 519
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 156 bits (394), Expect = 5e-38
Identities = 93/288 (32%), Positives = 152/288 (52%), Gaps = 32/288 (11%)
Query: 160 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 219
V++ Y ++ +GKG++ VVKL + T A+K++ K +L
Sbjct: 15 VRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQL------------------ 56
Query: 220 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-V 278
+E++Y+E+ I+K LDHP+++KL +V++ + LY+V E G + + +
Sbjct: 57 ------DAVNLEKIYREVQIMKMLDHPHIIKLYQVME--TKSMLYLVTEYAKNGEIFDYL 108
Query: 279 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 338
L+E +AR F ++ ++Y H +KI+HRD+K NLL+ + +IKIADFG N FK
Sbjct: 109 ANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFK 168
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
S LL+ G+P + APE + + G LD+W+MGV LY V G PF + L
Sbjct: 169 -SGELLATWCGSPPYAAPEVFEGQQ--YEGPQLDIWSMGVVLYVLVCGALPFDGPTLPIL 225
Query: 399 HSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
++ P ++ED + LI RML +P R+ + +IK H W+
Sbjct: 226 RQRVLEGRFRIP--YFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWM 271
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 156 bits (394), Expect = 5e-38
Identities = 94/303 (31%), Positives = 156/303 (51%), Gaps = 32/303 (10%)
Query: 155 GMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPR 214
G Q +++ Y ++ +GKG++ VVKLA + T A+K++ K +L
Sbjct: 17 GQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL------------- 63
Query: 215 GTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGP 274
+E++Y+E+ ++K L+HP+++KL +V++ +D LY+V E G
Sbjct: 64 -----------DSSNLEKIYREVQLMKLLNHPHIIKLYQVME--TKDMLYIVTEFAKNGE 110
Query: 275 VMEVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGV 333
+ + T LSE++AR F ++ +EY H I+HRD+K NLL+ + IK+ADFG
Sbjct: 111 MFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGF 170
Query: 334 SNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDE 393
N +K + LS G+P + APE K + G LD+W++GV LY V G PF
Sbjct: 171 GNFYKSGEP-LSTWCGSPPYAAPEVFE--GKEYEGPQLDIWSLGVVLYVLVCGSLPFDGP 227
Query: 394 RIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEP 453
+ L ++ P +++D + LI RML +P RI + +I+ H W+ P
Sbjct: 228 NLPTLRQRVLEGRFRIPF--FMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLP 285
Query: 454 LPS 456
P+
Sbjct: 286 GPA 288
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 150 bits (380), Expect = 2e-36
Identities = 101/316 (31%), Positives = 161/316 (50%), Gaps = 38/316 (12%)
Query: 165 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCI 224
Y L +G+G + VVKLA + A+KV+ K KL A
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLA------------------- 56
Query: 225 QPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME--VPTLK 282
++QE+ +K + HPN+V+L EV+D + LY++ EL + G + + + +
Sbjct: 57 -----TGHLFQEVRCMKLVQHPNIVRLYEVID--TQTKLYLILELGDGGDMFDYIMKHEE 109
Query: 283 PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGE-DGHIKIADFGVSNEFKGSD 341
L+ED A+ YF ++ I Y H ++HRD+KP N++ E G +K+ DFG SN+F+
Sbjct: 110 GLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGK 169
Query: 342 ALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSK 401
L+ + G+ A+ APE L + A+D+W++GV L+ V GQ PF + +
Sbjct: 170 K-LTTSCGSLAYSAPEILLGDE--YDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTM 226
Query: 402 IKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENC 461
I P ++++ KDLITRML ++P+ R + EI+ HPW+ G +P P+ N
Sbjct: 227 IMDCKYTVPSH--VSKECKDLITRMLQRDPKRRASLEEIENHPWL--QGVDPSPATKYNI 282
Query: 462 TLVEV--TEEEVENSV 475
LV EE NS+
Sbjct: 283 PLVSYKNLSEEEHNSI 298
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 150 bits (380), Expect = 2e-36
Identities = 101/316 (31%), Positives = 161/316 (50%), Gaps = 38/316 (12%)
Query: 165 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCI 224
Y L +G+G + VVKLA + A+KV+ K KL A
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLA------------------- 56
Query: 225 QPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME--VPTLK 282
++QE+ +K + HPN+V+L EV+D + LY++ EL + G + + + +
Sbjct: 57 -----TGHLFQEVRCMKLVQHPNIVRLYEVID--TQTKLYLILELGDGGDMFDYIMKHEE 109
Query: 283 PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGE-DGHIKIADFGVSNEFKGSD 341
L+ED A+ YF ++ I Y H ++HRD+KP N++ E G +K+ DFG SN+F+
Sbjct: 110 GLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGK 169
Query: 342 ALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSK 401
L+ + G+ A+ APE L + A+D+W++GV L+ V GQ PF + +
Sbjct: 170 K-LTTSCGSLAYSAPEILLGDE--YDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTM 226
Query: 402 IKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENC 461
I P ++++ KDLITRML ++P+ R + EI+ HPW+ G +P P+ N
Sbjct: 227 IMDCKYTVPSH--VSKECKDLITRMLQRDPKRRASLEEIENHPWL--QGVDPSPATKYNI 282
Query: 462 TLVEV--TEEEVENSV 475
LV EE NS+
Sbjct: 283 PLVSYKNLSEEEHNSI 298
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 150 bits (378), Expect = 4e-36
Identities = 104/386 (26%), Positives = 185/386 (47%), Gaps = 44/386 (11%)
Query: 164 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGC 223
+Y L +E+GKG++ VV+ YA K+++ KKL +
Sbjct: 12 EYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH----------------- 54
Query: 224 IQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLK 282
+++ +E I + L HPN+V+L + + + E H Y++F+LV G + E + +
Sbjct: 55 -------QKLEREARICRLLKHPNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVARE 105
Query: 283 PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFKG 339
SE A Q +++ + + H ++HRD+KP NLL+ + +K+ADFG++ E +G
Sbjct: 106 YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG 165
Query: 340 SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLH 399
GTP +++PE L RK GK +D+WA GV LY + G PF DE L+
Sbjct: 166 EQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLY 222
Query: 400 SKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPL--- 454
+IK+ A +F P+ + + KDLI +ML NP RI E HPW++
Sbjct: 223 QQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMH 282
Query: 455 PSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFEGSRREERSLSAPG 514
E +C +++ ++ L T++ + +S GN ++ +S S+
Sbjct: 283 RQETVDCLKKFNARRKLKGAI-----LTTMLATRNFSGGKSGGNKKSDGVKKRKSSSSVQ 337
Query: 515 NLLTKQGSEDNLQGTDPPPVGEEEVL 540
+ + + + ++ D V ++E++
Sbjct: 338 LMESSESTNTTIEDED-TKVRKQEII 362
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 149 bits (377), Expect = 5e-36
Identities = 92/290 (31%), Positives = 149/290 (51%), Gaps = 35/290 (12%)
Query: 164 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGC 223
+Y L +E+GKG++ VV+ YA K+++ KKL +
Sbjct: 12 EYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH----------------- 54
Query: 224 IQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLK 282
+++ +E I + L HPN+V+L + + + E H Y++F+LV G + E + +
Sbjct: 55 -------QKLEREARICRLLKHPNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVARE 105
Query: 283 PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFKG 339
SE A Q +++ + + H ++HRD+KP NLL+ + +K+ADFG++ E +G
Sbjct: 106 YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG 165
Query: 340 SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLH 399
GTP +++PE L RK GK +D+WA GV LY + G PF DE L+
Sbjct: 166 EQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLY 222
Query: 400 SKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVT 447
+IK+ A +F P+ + + KDLI +ML NP RI E HPW++
Sbjct: 223 QQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 149 bits (376), Expect = 6e-36
Identities = 91/300 (30%), Positives = 157/300 (52%), Gaps = 32/300 (10%)
Query: 157 QDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGT 216
Q + Y L+ +GKG G+VKL + A+K+++++KL
Sbjct: 26 QHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESV----------- 74
Query: 217 RPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVM 276
+ +V +EIAILK ++HP+V+KL +V + N+ +LY+V E V+ G +
Sbjct: 75 -------------LMKVEREIAILKLIEHPHVLKLHDVYE--NKKYLYLVLEHVSGGELF 119
Query: 277 EVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSN 335
+ K L+ +AR +F+ ++ +++ H I HRD+KP NLL+ E +I+IADFG+++
Sbjct: 120 DYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMAS 179
Query: 336 EFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERI 395
+ D+LL + G+P + PE + + + G+ D+W+ GV L+ + G PF D+ +
Sbjct: 180 -LQVGDSLLETSCGSPHYACPEVIKGEK--YDGRRADMWSCGVILFALLVGALPFDDDNL 236
Query: 396 MCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLP 455
L K+K P I D + L+ M++ PE R+ + +I+ HPW EP P
Sbjct: 237 RQLLEKVKRGVFHMPH--FIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDP 294
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 148 bits (373), Expect = 1e-35
Identities = 93/290 (32%), Positives = 147/290 (50%), Gaps = 35/290 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
++Y L +E+GKG++ VV+ YA K+++ KKL +
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
+ SE A Q +++ + + H I+HRD+KP NLL+ +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
+ +IK+ A +F P+ + + KDLI +ML NP RI E HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 148 bits (373), Expect = 1e-35
Identities = 93/290 (32%), Positives = 147/290 (50%), Gaps = 35/290 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
++Y L +E+GKG++ VV+ YA K+++ KKL +
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
+ SE A Q +++ + + H I+HRD+KP NLL+ +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
+ +IK+ A +F P+ + + KDLI +ML NP RI E HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 148 bits (373), Expect = 1e-35
Identities = 93/290 (32%), Positives = 147/290 (50%), Gaps = 35/290 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
++Y L +E+GKG++ VV+ YA K+++ KKL +
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
+ SE A Q +++ + + H I+HRD+KP NLL+ +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
+ +IK+ A +F P+ + + KDLI +ML NP RI E HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 148 bits (373), Expect = 1e-35
Identities = 93/290 (32%), Positives = 147/290 (50%), Gaps = 35/290 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
++Y L +E+GKG++ VV+ YA K+++ KKL +
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
+ SE A Q +++ + + H I+HRD+KP NLL+ +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
+ +IK+ A +F P+ + + KDLI +ML NP RI E HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 148 bits (373), Expect = 1e-35
Identities = 93/290 (32%), Positives = 147/290 (50%), Gaps = 35/290 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
++Y L +E+GKG++ VV+ YA K+++ KKL +
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
+ SE A Q +++ + + H I+HRD+KP NLL+ +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
+ +IK+ A +F P+ + + KDLI +ML NP RI E HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 148 bits (373), Expect = 1e-35
Identities = 93/290 (32%), Positives = 147/290 (50%), Gaps = 35/290 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
++Y L +E+GKG++ VV+ YA K+++ KKL +
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
+ SE A Q +++ + + H I+HRD+KP NLL+ +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
+ +IK+ A +F P+ + + KDLI +ML NP RI E HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 147 bits (371), Expect = 2e-35
Identities = 91/290 (31%), Positives = 148/290 (51%), Gaps = 35/290 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
+ Y L +E+GKG++ VV+ + YA K+++ KKL +
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
+ SE A +++ + ++H I+HRD+KP NLL+ + +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
+ +IK+ A +F P+ + + K+LI +ML NP RI + HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 147 bits (371), Expect = 2e-35
Identities = 91/290 (31%), Positives = 148/290 (51%), Gaps = 35/290 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
+ Y L +E+GKG++ VV+ + YA K+++ KKL +
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
+ SE A +++ + ++H I+HRD+KP NLL+ + +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
+ +IK+ A +F P+ + + K+LI +ML NP RI + HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 147 bits (371), Expect = 2e-35
Identities = 91/290 (31%), Positives = 148/290 (51%), Gaps = 35/290 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
+ Y L +E+GKG++ VV+ + YA K+++ KKL +
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
+ SE A +++ + ++H I+HRD+KP NLL+ + +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
+ +IK+ A +F P+ + + K+LI +ML NP RI + HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 147 bits (371), Expect = 2e-35
Identities = 91/290 (31%), Positives = 148/290 (51%), Gaps = 35/290 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
+ Y L +E+GKG++ VV+ + YA K+++ KKL +
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
+ SE A +++ + ++H I+HRD+KP NLL+ + +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
+ +IK+ A +F P+ + + K+LI +ML NP RI + HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 147 bits (371), Expect = 2e-35
Identities = 91/290 (31%), Positives = 148/290 (51%), Gaps = 35/290 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
+ Y L +E+GKG++ VV+ + YA K+++ KKL +
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
+ SE A +++ + ++H I+HRD+KP NLL+ + +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
+ +IK+ A +F P+ + + K+LI +ML NP RI + HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]
Length = 433
Score = 146 bits (369), Expect = 4e-35
Identities = 99/288 (34%), Positives = 142/288 (49%), Gaps = 29/288 (10%)
Query: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221
+ +Y + D +G+GSYG VK + A+K+L KKKL R P
Sbjct: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90
Query: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279
G V +EI +L++L H NV++LV+VL + + +YMV E G +++
Sbjct: 91 G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143
Query: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338
K QA YF LI G+EYLH Q I+H+DIKP NLL+ G +KI+D GV+
Sbjct: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203
Query: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397
+D + G+PAF PE ++ FSG +D+W+ GVTLY G PF + I
Sbjct: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262
Query: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 445
L I + P D L DL+ ML+ P R + +I+ H W
Sbjct: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSW 308
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 146 bits (368), Expect = 5e-35
Identities = 95/331 (28%), Positives = 162/331 (48%), Gaps = 45/331 (13%)
Query: 160 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 219
V++ Y L D +G G++G VK+ ++ A+K+L+++K
Sbjct: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK------------------- 51
Query: 220 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-V 278
I+ + ++ +EI LK HP+++KL +V+ P + +MV E V+ G + + +
Sbjct: 52 ----IRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTD--FFMVMEYVSGGELFDYI 105
Query: 279 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 338
+ E +AR FQ ++ ++Y H ++HRD+KP N+L+ + KIADFG+SN
Sbjct: 106 CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
+ L + G+P + APE +S ++++G +D+W+ GV LY + G PF DE + L
Sbjct: 166 DGE-FLRTSCGSPNYAAPEVIS--GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL 222
Query: 399 HSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPL---- 454
KI+ P+ + + L+ ML +P R + +I+ H W + L
Sbjct: 223 FKKIRGGVFYIPEY--LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPED 280
Query: 455 PSEDEN----------CTLVEVTEEEVENSV 475
PS D N C E TE EV NS+
Sbjct: 281 PSYDANVIDDEAVKEVCEKFECTESEVMNSL 311
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.135 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,711,992
Number of Sequences: 37866
Number of extensions: 1192949
Number of successful extensions: 5683
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 730
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 3316
Number of HSP's gapped (non-prelim): 1182
length of query: 541
length of database: 18,247,518
effective HSP length: 107
effective length of query: 434
effective length of database: 14,195,856
effective search space: 6161001504
effective search space used: 6161001504
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.