Guide to the Human Genome
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Search of human proteins with 27437021

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27437021 calcium/calmodulin-dependent protein kinase kinase
2 beta isoform 5 [Homo sapiens]
         (533 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2...  1075   0.0  
gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2...  1073   0.0  
gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2...  1048   0.0  
gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2...  1048   0.0  
gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2...   966   0.0  
gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2...   964   0.0  
gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2...   939   0.0  
gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha ...   588   e-168
gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha ...   588   e-168
gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha...   566   e-161
gi|38569460 SNF1-like kinase 2 [Homo sapiens]                         156   5e-38
gi|116256471 SNF1-like kinase [Homo sapiens]                          156   5e-38
gi|156105707 SNF related kinase [Homo sapiens]                        150   2e-36
gi|156105705 SNF related kinase [Homo sapiens]                        150   2e-36
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha...   149   5e-36
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha...   149   5e-36
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]               149   6e-36
gi|212549756 calcium/calmodulin-dependent protein kinase II delt...   148   1e-35
gi|26667183 calcium/calmodulin-dependent protein kinase II delta...   148   1e-35
gi|212549753 calcium/calmodulin-dependent protein kinase II delt...   148   1e-35
gi|26667186 calcium/calmodulin-dependent protein kinase II delta...   148   1e-35
gi|26667189 calcium/calmodulin-dependent protein kinase II delta...   148   1e-35
gi|26667180 calcium/calmodulin-dependent protein kinase II delta...   148   1e-35
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma...   147   2e-35
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma...   147   2e-35
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma...   147   2e-35
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma...   147   2e-35
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma...   147   2e-35
gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]          146   4e-35
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...   146   5e-35

>gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 5 [Homo sapiens]
          Length = 533

 Score = 1075 bits (2780), Expect = 0.0
 Identities = 533/533 (100%), Positives = 533/533 (100%)

Query: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
           MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60

Query: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
           GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120

Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
           CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180

Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
           LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240

Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
           KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300

Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
           EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360

Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
           ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420

Query: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
           DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480

Query: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKT 533
           LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKT
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKT 533


>gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 1 [Homo sapiens]
          Length = 588

 Score = 1073 bits (2775), Expect = 0.0
 Identities = 532/532 (100%), Positives = 532/532 (100%)

Query: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
           MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60

Query: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
           GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120

Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
           CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180

Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
           LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240

Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
           KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300

Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
           EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360

Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
           ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420

Query: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
           DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480

Query: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELK 532
           LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELK
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELK 532


>gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 2 [Homo sapiens]
          Length = 541

 Score = 1048 bits (2710), Expect = 0.0
 Identities = 519/524 (99%), Positives = 522/524 (99%)

Query: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
           MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60

Query: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
           GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120

Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
           CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180

Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
           LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240

Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
           KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300

Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
           EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360

Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
           ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420

Query: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
           DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480

Query: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRE 524
           LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTK+ + +
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSED 524


>gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 2 [Homo sapiens]
          Length = 541

 Score = 1048 bits (2710), Expect = 0.0
 Identities = 519/524 (99%), Positives = 522/524 (99%)

Query: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
           MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60

Query: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
           GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120

Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
           CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180

Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
           LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240

Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
           KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300

Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
           EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360

Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
           ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420

Query: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
           DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480

Query: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRE 524
           LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTK+ + +
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSED 524


>gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 6 [Homo sapiens]
          Length = 490

 Score =  966 bits (2496), Expect = 0.0
 Identities = 490/533 (91%), Positives = 490/533 (91%), Gaps = 43/533 (8%)

Query: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
           MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60

Query: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
           GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120

Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
           CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180

Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
           LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240

Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
           KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300

Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
           EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360

Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
           ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420

Query: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
           DLITRMLDKNPESRIVVPEIK                                       
Sbjct: 421 DLITRMLDKNPESRIVVPEIK--------------------------------------- 441

Query: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKT 533
               ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKT
Sbjct: 442 ----ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKT 490


>gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 3 [Homo sapiens]
          Length = 545

 Score =  964 bits (2491), Expect = 0.0
 Identities = 489/532 (91%), Positives = 489/532 (91%), Gaps = 43/532 (8%)

Query: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
           MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60

Query: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
           GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120

Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
           CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180

Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
           LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240

Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
           KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300

Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
           EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360

Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
           ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420

Query: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
           DLITRMLDKNPESRIVVPEIK                                       
Sbjct: 421 DLITRMLDKNPESRIVVPEIK--------------------------------------- 441

Query: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELK 532
               ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELK
Sbjct: 442 ----ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELK 489


>gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 4 [Homo sapiens]
          Length = 498

 Score =  939 bits (2426), Expect = 0.0
 Identities = 476/524 (90%), Positives = 479/524 (91%), Gaps = 43/524 (8%)

Query: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
           MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60

Query: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
           GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120

Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
           CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180

Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
           LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240

Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
           KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300

Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
           EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360

Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
           ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420

Query: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
           DLITRMLDKNPESRIVVPEIK                                       
Sbjct: 421 DLITRMLDKNPESRIVVPEIK--------------------------------------- 441

Query: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRE 524
               ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTK+ + +
Sbjct: 442 ----ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSED 481


>gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha
           isoform a [Homo sapiens]
          Length = 505

 Score =  588 bits (1515), Expect = e-168
 Identities = 289/432 (66%), Positives = 362/432 (83%), Gaps = 12/432 (2%)

Query: 90  ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
           ARP LS RKLSLQER      AG  L+          PY+   +   SPR  RRPT+ESH
Sbjct: 64  ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112

Query: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
           HV+I+  +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172

Query: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269
           RPPPRG++ A GG  +   P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232

Query: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329
           + +GPVMEVP  KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292

Query: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389
           DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352

Query: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 449
           F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++
Sbjct: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412

Query: 450 GAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREER 508
           G EPLPSE+E+C++VEVTEEEV+NSV+ IPS  TVILVK+M+RKRSFGNPFE  +RREER
Sbjct: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472

Query: 509 SLSAPGNLLTKK 520
           S+SAPGNLL K+
Sbjct: 473 SMSAPGNLLVKE 484


>gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha
           isoform a [Homo sapiens]
          Length = 505

 Score =  588 bits (1515), Expect = e-168
 Identities = 289/432 (66%), Positives = 362/432 (83%), Gaps = 12/432 (2%)

Query: 90  ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
           ARP LS RKLSLQER      AG  L+          PY+   +   SPR  RRPT+ESH
Sbjct: 64  ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112

Query: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
           HV+I+  +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172

Query: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269
           RPPPRG++ A GG  +   P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232

Query: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329
           + +GPVMEVP  KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292

Query: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389
           DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352

Query: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 449
           F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++
Sbjct: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412

Query: 450 GAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREER 508
           G EPLPSE+E+C++VEVTEEEV+NSV+ IPS  TVILVK+M+RKRSFGNPFE  +RREER
Sbjct: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472

Query: 509 SLSAPGNLLTKK 520
           S+SAPGNLL K+
Sbjct: 473 SMSAPGNLLVKE 484


>gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha
           isoform b [Homo sapiens]
          Length = 520

 Score =  567 bits (1460), Expect = e-161
 Identities = 288/467 (61%), Positives = 360/467 (77%), Gaps = 50/467 (10%)

Query: 90  ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
           ARP LS RKLSLQER      AG  L+          PY+   +   SPR  RRPT+ESH
Sbjct: 64  ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112

Query: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
           HV+I+  +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172

Query: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYM---- 265
           RPPPRG++ A GG  +   P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+    
Sbjct: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQN 232

Query: 266 ----------------------------------VFELVNQGPVMEVPTLKPLSEDQARF 291
                                             VF+L+ +GPVMEVP  KP SE+QAR 
Sbjct: 233 QAQNIQLDSTNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARL 292

Query: 292 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 351
           Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIADFGVSN+F+G+DA LS+T GTP
Sbjct: 293 YLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP 352

Query: 352 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPD 411
           AFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CPF+D+ I+ LH KIK++ + FP+
Sbjct: 353 AFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPE 412

Query: 412 QPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEV 471
           +P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++G EPLPSE+E+C++VEVTEEEV
Sbjct: 413 EPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEV 472

Query: 472 ENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREERSLSAPGNLL 517
           +NSV+ IPS  TVILVK+M+RKRSFGNPFE  +RREERS+SAPGNLL
Sbjct: 473 KNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLL 519


>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
          Length = 926

 Score =  156 bits (394), Expect = 5e-38
 Identities = 93/288 (32%), Positives = 152/288 (52%), Gaps = 32/288 (11%)

Query: 160 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 219
           V++  Y ++  +GKG++ VVKL  +    T  A+K++ K +L                  
Sbjct: 15  VRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQL------------------ 56

Query: 220 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-V 278
                     +E++Y+E+ I+K LDHP+++KL +V++   +  LY+V E    G + + +
Sbjct: 57  ------DAVNLEKIYREVQIMKMLDHPHIIKLYQVME--TKSMLYLVTEYAKNGEIFDYL 108

Query: 279 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 338
                L+E +AR  F  ++  ++Y H +KI+HRD+K  NLL+  + +IKIADFG  N FK
Sbjct: 109 ANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFK 168

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
            S  LL+   G+P + APE     +  + G  LD+W+MGV LY  V G  PF    +  L
Sbjct: 169 -SGELLATWCGSPPYAAPEVFEGQQ--YEGPQLDIWSMGVVLYVLVCGALPFDGPTLPIL 225

Query: 399 HSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
             ++       P    ++ED + LI RML  +P  R+ + +IK H W+
Sbjct: 226 RQRVLEGRFRIP--YFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWM 271


>gi|116256471 SNF1-like kinase [Homo sapiens]
          Length = 783

 Score =  156 bits (394), Expect = 5e-38
 Identities = 94/303 (31%), Positives = 156/303 (51%), Gaps = 32/303 (10%)

Query: 155 GMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPR 214
           G Q  +++  Y ++  +GKG++ VVKLA +    T  A+K++ K +L             
Sbjct: 17  GQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL------------- 63

Query: 215 GTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGP 274
                          +E++Y+E+ ++K L+HP+++KL +V++   +D LY+V E    G 
Sbjct: 64  -----------DSSNLEKIYREVQLMKLLNHPHIIKLYQVME--TKDMLYIVTEFAKNGE 110

Query: 275 VMEVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGV 333
           + +  T    LSE++AR  F  ++  +EY H   I+HRD+K  NLL+  +  IK+ADFG 
Sbjct: 111 MFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGF 170

Query: 334 SNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDE 393
            N +K  +  LS   G+P + APE      K + G  LD+W++GV LY  V G  PF   
Sbjct: 171 GNFYKSGEP-LSTWCGSPPYAAPEVFE--GKEYEGPQLDIWSLGVVLYVLVCGSLPFDGP 227

Query: 394 RIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEP 453
            +  L  ++       P    +++D + LI RML  +P  RI + +I+ H W+      P
Sbjct: 228 NLPTLRQRVLEGRFRIPF--FMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLP 285

Query: 454 LPS 456
            P+
Sbjct: 286 GPA 288


>gi|156105707 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  150 bits (380), Expect = 2e-36
 Identities = 101/316 (31%), Positives = 161/316 (50%), Gaps = 38/316 (12%)

Query: 165 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCI 224
           Y L   +G+G + VVKLA +       A+KV+ K KL   A                   
Sbjct: 16  YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLA------------------- 56

Query: 225 QPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME--VPTLK 282
                   ++QE+  +K + HPN+V+L EV+D   +  LY++ EL + G + +  +   +
Sbjct: 57  -----TGHLFQEVRCMKLVQHPNIVRLYEVID--TQTKLYLILELGDGGDMFDYIMKHEE 109

Query: 283 PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGE-DGHIKIADFGVSNEFKGSD 341
            L+ED A+ YF  ++  I Y H   ++HRD+KP N++  E  G +K+ DFG SN+F+   
Sbjct: 110 GLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGK 169

Query: 342 ALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSK 401
             L+ + G+ A+ APE L      +   A+D+W++GV L+  V GQ PF +       + 
Sbjct: 170 K-LTTSCGSLAYSAPEILLGDE--YDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTM 226

Query: 402 IKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENC 461
           I       P    ++++ KDLITRML ++P+ R  + EI+ HPW+   G +P P+   N 
Sbjct: 227 IMDCKYTVPSH--VSKECKDLITRMLQRDPKRRASLEEIENHPWL--QGVDPSPATKYNI 282

Query: 462 TLVEV--TEEEVENSV 475
            LV      EE  NS+
Sbjct: 283 PLVSYKNLSEEEHNSI 298


>gi|156105705 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  150 bits (380), Expect = 2e-36
 Identities = 101/316 (31%), Positives = 161/316 (50%), Gaps = 38/316 (12%)

Query: 165 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCI 224
           Y L   +G+G + VVKLA +       A+KV+ K KL   A                   
Sbjct: 16  YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLA------------------- 56

Query: 225 QPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME--VPTLK 282
                   ++QE+  +K + HPN+V+L EV+D   +  LY++ EL + G + +  +   +
Sbjct: 57  -----TGHLFQEVRCMKLVQHPNIVRLYEVID--TQTKLYLILELGDGGDMFDYIMKHEE 109

Query: 283 PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGE-DGHIKIADFGVSNEFKGSD 341
            L+ED A+ YF  ++  I Y H   ++HRD+KP N++  E  G +K+ DFG SN+F+   
Sbjct: 110 GLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGK 169

Query: 342 ALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSK 401
             L+ + G+ A+ APE L      +   A+D+W++GV L+  V GQ PF +       + 
Sbjct: 170 K-LTTSCGSLAYSAPEILLGDE--YDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTM 226

Query: 402 IKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENC 461
           I       P    ++++ KDLITRML ++P+ R  + EI+ HPW+   G +P P+   N 
Sbjct: 227 IMDCKYTVPSH--VSKECKDLITRMLQRDPKRRASLEEIENHPWL--QGVDPSPATKYNI 282

Query: 462 TLVEV--TEEEVENSV 475
            LV      EE  NS+
Sbjct: 283 PLVSYKNLSEEEHNSI 298


>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
           isoform 2 [Homo sapiens]
          Length = 478

 Score =  149 bits (377), Expect = 5e-36
 Identities = 92/290 (31%), Positives = 149/290 (51%), Gaps = 35/290 (12%)

Query: 164 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGC 223
           +Y L +E+GKG++ VV+          YA K+++ KKL  +                   
Sbjct: 12  EYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH----------------- 54

Query: 224 IQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLK 282
                  +++ +E  I + L HPN+V+L + + +  E H Y++F+LV  G + E +   +
Sbjct: 55  -------QKLEREARICRLLKHPNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVARE 105

Query: 283 PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFKG 339
             SE  A    Q +++ + + H   ++HRD+KP NLL+    +   +K+ADFG++ E +G
Sbjct: 106 YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG 165

Query: 340 SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLH 399
                    GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L+
Sbjct: 166 EQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLY 222

Query: 400 SKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVT 447
            +IK+ A +F  P+   +  + KDLI +ML  NP  RI   E   HPW++
Sbjct: 223 QQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272


>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
           isoform 1 [Homo sapiens]
          Length = 489

 Score =  149 bits (377), Expect = 5e-36
 Identities = 92/290 (31%), Positives = 149/290 (51%), Gaps = 35/290 (12%)

Query: 164 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGC 223
           +Y L +E+GKG++ VV+          YA K+++ KKL  +                   
Sbjct: 12  EYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH----------------- 54

Query: 224 IQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLK 282
                  +++ +E  I + L HPN+V+L + + +  E H Y++F+LV  G + E +   +
Sbjct: 55  -------QKLEREARICRLLKHPNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVARE 105

Query: 283 PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFKG 339
             SE  A    Q +++ + + H   ++HRD+KP NLL+    +   +K+ADFG++ E +G
Sbjct: 106 YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG 165

Query: 340 SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLH 399
                    GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L+
Sbjct: 166 EQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLY 222

Query: 400 SKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVT 447
            +IK+ A +F  P+   +  + KDLI +ML  NP  RI   E   HPW++
Sbjct: 223 QQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272


>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
          Length = 778

 Score =  149 bits (376), Expect = 6e-36
 Identities = 91/300 (30%), Positives = 157/300 (52%), Gaps = 32/300 (10%)

Query: 157 QDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGT 216
           Q    +  Y L+  +GKG  G+VKL  +       A+K+++++KL               
Sbjct: 26  QHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESV----------- 74

Query: 217 RPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVM 276
                        + +V +EIAILK ++HP+V+KL +V +  N+ +LY+V E V+ G + 
Sbjct: 75  -------------LMKVEREIAILKLIEHPHVLKLHDVYE--NKKYLYLVLEHVSGGELF 119

Query: 277 EVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSN 335
           +    K  L+  +AR +F+ ++  +++ H   I HRD+KP NLL+ E  +I+IADFG+++
Sbjct: 120 DYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMAS 179

Query: 336 EFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERI 395
             +  D+LL  + G+P +  PE +   +  + G+  D+W+ GV L+  + G  PF D+ +
Sbjct: 180 -LQVGDSLLETSCGSPHYACPEVIKGEK--YDGRRADMWSCGVILFALLVGALPFDDDNL 236

Query: 396 MCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLP 455
             L  K+K      P    I  D + L+  M++  PE R+ + +I+ HPW      EP P
Sbjct: 237 RQLLEKVKRGVFHMPH--FIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDP 294


>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
           isoform 4 [Homo sapiens]
          Length = 489

 Score =  148 bits (373), Expect = 1e-35
 Identities = 93/290 (32%), Positives = 147/290 (50%), Gaps = 35/290 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           ++Y L +E+GKG++ VV+          YA K+++ KKL  +                  
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
           +  SE  A    Q +++ + + H   I+HRD+KP NLL+        +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
           + +IK+ A +F  P+   +  + KDLI +ML  NP  RI   E   HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
           isoform 1 [Homo sapiens]
          Length = 478

 Score =  148 bits (373), Expect = 1e-35
 Identities = 93/290 (32%), Positives = 147/290 (50%), Gaps = 35/290 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           ++Y L +E+GKG++ VV+          YA K+++ KKL  +                  
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
           +  SE  A    Q +++ + + H   I+HRD+KP NLL+        +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
           + +IK+ A +F  P+   +  + KDLI +ML  NP  RI   E   HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
           isoform 5 [Homo sapiens]
          Length = 492

 Score =  148 bits (373), Expect = 1e-35
 Identities = 93/290 (32%), Positives = 147/290 (50%), Gaps = 35/290 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           ++Y L +E+GKG++ VV+          YA K+++ KKL  +                  
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
           +  SE  A    Q +++ + + H   I+HRD+KP NLL+        +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
           + +IK+ A +F  P+   +  + KDLI +ML  NP  RI   E   HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
           isoform 1 [Homo sapiens]
          Length = 478

 Score =  148 bits (373), Expect = 1e-35
 Identities = 93/290 (32%), Positives = 147/290 (50%), Gaps = 35/290 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           ++Y L +E+GKG++ VV+          YA K+++ KKL  +                  
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
           +  SE  A    Q +++ + + H   I+HRD+KP NLL+        +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
           + +IK+ A +F  P+   +  + KDLI +ML  NP  RI   E   HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
           isoform 2 [Homo sapiens]
          Length = 478

 Score =  148 bits (373), Expect = 1e-35
 Identities = 93/290 (32%), Positives = 147/290 (50%), Gaps = 35/290 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           ++Y L +E+GKG++ VV+          YA K+++ KKL  +                  
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
           +  SE  A    Q +++ + + H   I+HRD+KP NLL+        +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
           + +IK+ A +F  P+   +  + KDLI +ML  NP  RI   E   HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
           isoform 3 [Homo sapiens]
          Length = 499

 Score =  148 bits (373), Expect = 1e-35
 Identities = 93/290 (32%), Positives = 147/290 (50%), Gaps = 35/290 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           ++Y L +E+GKG++ VV+          YA K+++ KKL  +                  
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
           +  SE  A    Q +++ + + H   I+HRD+KP NLL+        +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
           + +IK+ A +F  P+   +  + KDLI +ML  NP  RI   E   HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
           isoform 3 [Homo sapiens]
          Length = 518

 Score =  147 bits (371), Expect = 2e-35
 Identities = 91/290 (31%), Positives = 148/290 (51%), Gaps = 35/290 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           + Y L +E+GKG++ VV+    +     YA K+++ KKL  +                  
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
           +  SE  A      +++ + ++H   I+HRD+KP NLL+    +   +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
           + +IK+ A +F  P+   +  + K+LI +ML  NP  RI   +   HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
           isoform 4 [Homo sapiens]
          Length = 495

 Score =  147 bits (371), Expect = 2e-35
 Identities = 91/290 (31%), Positives = 148/290 (51%), Gaps = 35/290 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           + Y L +E+GKG++ VV+    +     YA K+++ KKL  +                  
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
           +  SE  A      +++ + ++H   I+HRD+KP NLL+    +   +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
           + +IK+ A +F  P+   +  + K+LI +ML  NP  RI   +   HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
           isoform 6 [Homo sapiens]
          Length = 504

 Score =  147 bits (371), Expect = 2e-35
 Identities = 91/290 (31%), Positives = 148/290 (51%), Gaps = 35/290 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           + Y L +E+GKG++ VV+    +     YA K+++ KKL  +                  
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
           +  SE  A      +++ + ++H   I+HRD+KP NLL+    +   +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
           + +IK+ A +F  P+   +  + K+LI +ML  NP  RI   +   HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
           isoform 1 [Homo sapiens]
          Length = 556

 Score =  147 bits (371), Expect = 2e-35
 Identities = 91/290 (31%), Positives = 148/290 (51%), Gaps = 35/290 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           + Y L +E+GKG++ VV+    +     YA K+++ KKL  +                  
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
           +  SE  A      +++ + ++H   I+HRD+KP NLL+    +   +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
           + +IK+ A +F  P+   +  + K+LI +ML  NP  RI   +   HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
           isoform 2 [Homo sapiens]
          Length = 527

 Score =  147 bits (371), Expect = 2e-35
 Identities = 91/290 (31%), Positives = 148/290 (51%), Gaps = 35/290 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           + Y L +E+GKG++ VV+    +     YA K+++ KKL  +                  
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
           +  SE  A      +++ + ++H   I+HRD+KP NLL+    +   +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
           + +IK+ A +F  P+   +  + K+LI +ML  NP  RI   +   HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]
          Length = 433

 Score =  146 bits (369), Expect = 4e-35
 Identities = 99/288 (34%), Positives = 142/288 (49%), Gaps = 29/288 (10%)

Query: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221
           + +Y + D +G+GSYG VK   +       A+K+L KKKL               R  P 
Sbjct: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90

Query: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279
           G          V +EI +L++L H NV++LV+VL +  +  +YMV E    G   +++  
Sbjct: 91  G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143

Query: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338
             K     QA  YF  LI G+EYLH Q I+H+DIKP NLL+   G +KI+D GV+     
Sbjct: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203

Query: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397
             +D     + G+PAF  PE ++     FSG  +D+W+ GVTLY    G  PF  + I  
Sbjct: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262

Query: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 445
           L   I   +   P   D    L DL+  ML+  P  R  + +I+ H W
Sbjct: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSW 308


>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score =  146 bits (368), Expect = 5e-35
 Identities = 95/331 (28%), Positives = 162/331 (48%), Gaps = 45/331 (13%)

Query: 160 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 219
           V++  Y L D +G G++G VK+  ++      A+K+L+++K                   
Sbjct: 11  VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK------------------- 51

Query: 220 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-V 278
               I+    + ++ +EI  LK   HP+++KL +V+  P +   +MV E V+ G + + +
Sbjct: 52  ----IRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTD--FFMVMEYVSGGELFDYI 105

Query: 279 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 338
                + E +AR  FQ ++  ++Y H   ++HRD+KP N+L+    + KIADFG+SN   
Sbjct: 106 CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
             +  L  + G+P + APE +S   ++++G  +D+W+ GV LY  + G  PF DE +  L
Sbjct: 166 DGE-FLRTSCGSPNYAAPEVIS--GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL 222

Query: 399 HSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPL---- 454
             KI+      P+   +   +  L+  ML  +P  R  + +I+ H W  +     L    
Sbjct: 223 FKKIRGGVFYIPEY--LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPED 280

Query: 455 PSEDEN----------CTLVEVTEEEVENSV 475
           PS D N          C   E TE EV NS+
Sbjct: 281 PSYDANVIDDEAVKEVCEKFECTESEVMNSL 311


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,753,461
Number of Sequences: 37866
Number of extensions: 1131895
Number of successful extensions: 6646
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 730
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 4188
Number of HSP's gapped (non-prelim): 1211
length of query: 533
length of database: 18,247,518
effective HSP length: 107
effective length of query: 426
effective length of database: 14,195,856
effective search space: 6047434656
effective search space used: 6047434656
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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