Search of human proteins with 27436969

Search of human proteins with 27436969

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27436969 potassium voltage-gated channel, shaker-related
subfamily, beta member 2 isoform 2 [Homo sapiens]
         (353 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27436969 potassium voltage-gated channel, shaker-related subf...   709   0.0  
gi|4504825 potassium voltage-gated channel, shaker-related subfa...   700   0.0  
gi|27436962 potassium voltage-gated channel, shaker-related subf...   591   e-169
gi|27436964 potassium voltage-gated channel, shaker-related subf...   588   e-168
gi|27436966 potassium voltage-gated channel, shaker-related subf...   587   e-168
gi|27436971 potassium voltage-gated channel, shaker-related subf...   521   e-148
gi|41327764 aldo-keto reductase family 7, member A2 [Homo sapiens]     87   2e-17
gi|223718702 aflatoxin B1 aldehyde reductase 3 isoform 1 [Homo s...    86   5e-17
gi|41152114 aldo-keto reductase family 7, member A3 [Homo sapiens]     83   3e-16
gi|223718708 aflatoxin B1 aldehyde reductase 3 isoform 2 [Homo s...    59   5e-09
gi|24497577 aldo-keto reductase family 1, member A1 [Homo sapiens]     45   8e-05
gi|5174391 aldo-keto reductase family 1, member A1 [Homo sapiens]      45   8e-05
gi|4502049 aldo-keto reductase family 1, member B1 [Homo sapiens]      44   3e-04
gi|45446745 aldo-keto reductase family 1, member C2 [Homo sapiens]     38   0.012
gi|4503285 aldo-keto reductase family 1, member C2 [Homo sapiens]      38   0.012
gi|93277124 aldo-keto reductase family 1, member C-like 2 [Homo ...    35   0.10 
gi|5453543 aldo-keto reductase family 1, member C1 [Homo sapiens]      34   0.17 
gi|207028673 hypothetical protein LOC100134257 [Homo sapiens]          34   0.17 
gi|24497583 aldo-keto reductase family 1, member C3 [Homo sapiens]     34   0.23 
gi|24497585 aldo-keto reductase family 1, member C4 [Homo sapiens]     32   0.86 
gi|5174695 aldo-keto reductase family 1, member D1 [Homo sapiens]      30   3.3  
gi|58530886 interleukin-1 receptor-associated kinase 2 [Homo sap...    29   7.3  
gi|55749758 DIP2 disco-interacting protein 2 homolog B [Homo sap...    29   7.3  

>gi|27436969 potassium voltage-gated channel, shaker-related
           subfamily, beta member 2 isoform 2 [Homo sapiens]
          Length = 353

 Score =  709 bits (1831), Expect = 0.0
 Identities = 353/353 (100%), Positives = 353/353 (100%)

Query: 1   MYPESTTGSPARLSLRQTGSPGMIYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMT 60
           MYPESTTGSPARLSLRQTGSPGMIYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMT
Sbjct: 1   MYPESTTGSPARLSLRQTGSPGMIYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMT 60

Query: 61  LAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRK 120
           LAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRK
Sbjct: 61  LAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRK 120

Query: 121 HIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSME 180
           HIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSME
Sbjct: 121 HIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSME 180

Query: 181 IMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGK 240
           IMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGK
Sbjct: 181 IMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGK 240

Query: 241 YDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRN 300
           YDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRN
Sbjct: 241 YDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRN 300

Query: 301 EGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPYSKKDYRS 353
           EGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPYSKKDYRS
Sbjct: 301 EGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPYSKKDYRS 353


>gi|4504825 potassium voltage-gated channel, shaker-related
           subfamily, beta member 2 isoform 1 [Homo sapiens]
          Length = 367

 Score =  700 bits (1806), Expect = 0.0
 Identities = 353/367 (96%), Positives = 353/367 (96%), Gaps = 14/367 (3%)

Query: 1   MYPESTTGSPARLSLRQTGSPGMIY--------------RNLGKSGLRVSCLGLGTWVTF 46
           MYPESTTGSPARLSLRQTGSPGMIY              RNLGKSGLRVSCLGLGTWVTF
Sbjct: 1   MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTF 60

Query: 47  GGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF 106
           GGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF
Sbjct: 61  GGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF 120

Query: 107 WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG 166
           WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG
Sbjct: 121 WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG 180

Query: 167 MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA 226
           MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA
Sbjct: 181 MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA 240

Query: 227 MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG 286
           MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG
Sbjct: 241 MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG 300

Query: 287 CTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPY 346
           CTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPY
Sbjct: 301 CTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPY 360

Query: 347 SKKDYRS 353
           SKKDYRS
Sbjct: 361 SKKDYRS 367


>gi|27436962 potassium voltage-gated channel, shaker-related
           subfamily, beta member 1 isoform 2 [Homo sapiens]
          Length = 408

 Score =  591 bits (1523), Expect = e-169
 Identities = 283/343 (82%), Positives = 322/343 (93%), Gaps = 2/343 (0%)

Query: 13  LSLRQT--GSPGMIYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLF 70
           +SL++T     GM YRNLGKSGLRVSCLGLGTWVTFGGQI+DE+AE+LMT+AY++G+NLF
Sbjct: 66  ISLQETTRAETGMAYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLF 125

Query: 71  DTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASL 130
           DTAEVYAAGKAEV+LG+IIKKKGWRRSSLVITTK++WGGKAETERGLSRKHIIEGLK SL
Sbjct: 126 DTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSL 185

Query: 131 ERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQ 190
           +RLQLEYVDVVFANRPD NTPMEE VRAMTHVINQGMAMYWGTSRWS+MEIMEAYSVARQ
Sbjct: 186 QRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQ 245

Query: 191 FNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSR 250
           FN+ PP+CEQAEYH+FQREKVEVQLPEL+HKIGVGAMTWSPLACGI+SGKY +G+P  SR
Sbjct: 246 FNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSR 305

Query: 251 ASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGA 310
           ASLK YQWLK++I+SEEGR+QQ KLK+L  IAERLGCTLPQLA+AWCLRNEGVSSVLLG+
Sbjct: 306 ASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGS 365

Query: 311 SNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPYSKKDYRS 353
           S  +QL+EN+GAIQVLPK++S +++EID+IL NKPYSKKDYRS
Sbjct: 366 STPEQLIENLGAIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS 408


>gi|27436964 potassium voltage-gated channel, shaker-related
           subfamily, beta member 1 isoform 3 [Homo sapiens]
          Length = 401

 Score =  588 bits (1517), Expect = e-168
 Identities = 280/332 (84%), Positives = 316/332 (95%)

Query: 22  GMIYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKA 81
           GM YRNLGKSGLRVSCLGLGTWVTFGGQI+DE+AE+LMT+AY++G+NLFDTAEVYAAGKA
Sbjct: 70  GMKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKA 129

Query: 82  EVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 141
           EV+LG+IIKKKGWRRSSLVITTK++WGGKAETERGLSRKHIIEGLK SL+RLQLEYVDVV
Sbjct: 130 EVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVV 189

Query: 142 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQA 201
           FANRPD NTPMEE VRAMTHVINQGMAMYWGTSRWS+MEIMEAYSVARQFN+ PP+CEQA
Sbjct: 190 FANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQA 249

Query: 202 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD 261
           EYH+FQREKVEVQLPEL+HKIGVGAMTWSPLACGI+SGKY +G+P  SRASLK YQWLK+
Sbjct: 250 EYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKE 309

Query: 262 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIG 321
           +I+SEEGR+QQ KLK+L  IAERLGCTLPQLA+AWCLRNEGVSSVLLG+S  +QL+EN+G
Sbjct: 310 RIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLG 369

Query: 322 AIQVLPKLSSSIIHEIDSILGNKPYSKKDYRS 353
           AIQVLPK++S +++EID+IL NKPYSKKDYRS
Sbjct: 370 AIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS 401


>gi|27436966 potassium voltage-gated channel, shaker-related
           subfamily, beta member 1 isoform 1 [Homo sapiens]
          Length = 419

 Score =  587 bits (1512), Expect = e-168
 Identities = 279/332 (84%), Positives = 316/332 (95%)

Query: 22  GMIYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKA 81
           GM +RNLGKSGLRVSCLGLGTWVTFGGQI+DE+AE+LMT+AY++G+NLFDTAEVYAAGKA
Sbjct: 88  GMPHRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKA 147

Query: 82  EVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 141
           EV+LG+IIKKKGWRRSSLVITTK++WGGKAETERGLSRKHIIEGLK SL+RLQLEYVDVV
Sbjct: 148 EVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVV 207

Query: 142 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQA 201
           FANRPD NTPMEE VRAMTHVINQGMAMYWGTSRWS+MEIMEAYSVARQFN+ PP+CEQA
Sbjct: 208 FANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQA 267

Query: 202 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD 261
           EYH+FQREKVEVQLPEL+HKIGVGAMTWSPLACGI+SGKY +G+P  SRASLK YQWLK+
Sbjct: 268 EYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKE 327

Query: 262 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIG 321
           +I+SEEGR+QQ KLK+L  IAERLGCTLPQLA+AWCLRNEGVSSVLLG+S  +QL+EN+G
Sbjct: 328 RIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLG 387

Query: 322 AIQVLPKLSSSIIHEIDSILGNKPYSKKDYRS 353
           AIQVLPK++S +++EID+IL NKPYSKKDYRS
Sbjct: 388 AIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS 419


>gi|27436971 potassium voltage-gated channel, shaker-related
           subfamily, beta member 3 [Homo sapiens]
          Length = 404

 Score =  521 bits (1341), Expect = e-148
 Identities = 247/342 (72%), Positives = 297/342 (86%), Gaps = 1/342 (0%)

Query: 9   SPARLSLRQTG-SPGMIYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGI 67
           +PA      TG   GM YRNLGKSGLRVSCLGLGTWVTFG QI+DE AE ++T+AY++G+
Sbjct: 63  APAGALRESTGRGTGMKYRNLGKSGLRVSCLGLGTWVTFGSQISDETAEDVLTVAYEHGV 122

Query: 68  NLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLK 127
           NLFDTAEVYAAGKAE  LGNI+K KGWRRSS VITTKIFWGG+AETERGLSRKHIIEGL+
Sbjct: 123 NLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVITTKIFWGGQAETERGLSRKHIIEGLR 182

Query: 128 ASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSV 187
            SLERLQL YVD+VFANR DPN PMEE VRAMT+VINQG+A+YWGTSRW + EIMEAYS+
Sbjct: 183 GSLERLQLGYVDIVFANRSDPNCPMEEIVRAMTYVINQGLALYWGTSRWGAAEIMEAYSM 242

Query: 188 ARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPP 247
           ARQFNL PP+CEQAE+H+FQREKVE+QLPEL+HKIGVG++TW PLACG+++ KYD  +P 
Sbjct: 243 ARQFNLIPPVCEQAEHHLFQREKVEMQLPELYHKIGVGSVTWYPLACGLITSKYDGRVPD 302

Query: 248 YSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVL 307
             RAS+KGYQWLKDK+ SE+G++QQAK+ +L  +A +LGCT+ QLAIAWCLR+EGVSSVL
Sbjct: 303 TCRASIKGYQWLKDKVQSEDGKKQQAKVMDLLPVAHQLGCTVAQLAIAWCLRSEGVSSVL 362

Query: 308 LGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPYSKK 349
           LG S+A+QL+E++GA+QVL +L+   + EID +LGNKP+SKK
Sbjct: 363 LGVSSAEQLIEHLGALQVLSQLTPQTVMEIDGLLGNKPHSKK 404


>gi|41327764 aldo-keto reductase family 7, member A2 [Homo sapiens]
          Length = 359

 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 77/278 (27%), Positives = 127/278 (45%), Gaps = 22/278 (7%)

Query: 64  DNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF-WGGKAETERGLSRKHI 122
           + G    DTA +Y+ G++E +LG +    G     + I TK   W GK+     L    +
Sbjct: 65  ERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKS-----LKPDSV 119

Query: 123 IEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 182
              L+ SL+RLQ   VD+ + + PD  TP+EET+ A   +  +G  +  G S ++S E+ 
Sbjct: 120 RSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVA 179

Query: 183 EAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKY- 241
           E  ++ +      P   Q  Y+   R+ VE +L       G+    ++PLA G+++GKY 
Sbjct: 180 EICTLCKSNGWILPTVYQGMYNATTRQ-VETELFPCLRHFGLRFYAYNPLAGGLLTGKYK 238

Query: 242 ---DSGIPPYSRASLKGYQW---LKDKILSEEGRRQQAKL-KELQAIAERLGCTLPQLAI 294
                G  P  R    G  W    +++   E      A + K LQA       ++   A+
Sbjct: 239 YEDKDGKQPVGR--FFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAAL 296

Query: 295 AWC-----LRNEGVSSVLLGASNADQLMENIGAIQVLP 327
            W      L+     +V+LG S+ +QL +N+ A +  P
Sbjct: 297 RWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGP 334


>gi|223718702 aflatoxin B1 aldehyde reductase 3 isoform 1 [Homo
           sapiens]
          Length = 331

 Score = 85.9 bits (211), Expect = 5e-17
 Identities = 80/295 (27%), Positives = 134/295 (45%), Gaps = 23/295 (7%)

Query: 48  GQITDEMAEQLMTLAY-DNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF 106
           G+  D      +T A+ + G    DTA +Y+ G++E +LG +  + G     + I TK  
Sbjct: 20  GRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKAN 79

Query: 107 -WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQ 165
            W G +     L    +   L+ SL+RLQ   VD+ + + PD + P+EET+RA   +  +
Sbjct: 80  PWIGNS-----LKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAPVEETLRACHQLHQE 134

Query: 166 GMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVG 225
           G  +  G S +++ E+ E  ++ +      P   Q  Y    R+ VE +L       G+ 
Sbjct: 135 GKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQ-VETELFPCLRHFGLR 193

Query: 226 AMTWSPLACGIVSGKY----DSGIPPYSRASLKGYQW---LKDKILSEEGRRQQAKL-KE 277
              ++PLA G+++GKY      G  P  R    G QW    ++    E      A + K 
Sbjct: 194 FYAYNPLAGGLLTGKYKYEDKDGKQPVGR--FFGTQWAEIYRNHFWKEHHFEGIALVEKA 251

Query: 278 LQAIAERLGCTLPQLAIAWC-----LRNEGVSSVLLGASNADQLMENIGAIQVLP 327
           LQA       ++   A+ W      L+     +V+LG S+ +QL +N+ A +  P
Sbjct: 252 LQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGP 306


>gi|41152114 aldo-keto reductase family 7, member A3 [Homo sapiens]
          Length = 331

 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 78/294 (26%), Positives = 133/294 (45%), Gaps = 21/294 (7%)

Query: 48  GQITDEMAEQLMTLAY-DNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF 106
           G+  D      +T A+ + G    DTA VY+ G++E +LG +  + G     + I TK  
Sbjct: 20  GRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAI 79

Query: 107 WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG 166
                     L    +   L+ SL+RLQ   VD+ + + PD +TP+EET+RA   +  +G
Sbjct: 80  ----PLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEG 135

Query: 167 MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA 226
             +  G S +++ E+ E  ++ +      P   Q  Y+   R+ VE +L       G+  
Sbjct: 136 KFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQ-VETELFPCLRHFGLRF 194

Query: 227 MTWSPLACGIVSGKY----DSGIPPYSRASLKGYQW---LKDKILSEEGRRQQAKL-KEL 278
             ++PLA G+++GKY     +G  P  R    G  W    +++   E      A + K L
Sbjct: 195 YAFNPLAGGLLTGKYKYEDKNGKQPVGR--FFGNTWAEMYRNRYWKEHHFEGIALVEKAL 252

Query: 279 QAIAERLGCTLPQLAIAWC-----LRNEGVSSVLLGASNADQLMENIGAIQVLP 327
           QA       ++    + W      L+     +V+LG S+ +QL +N+ A +  P
Sbjct: 253 QAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGP 306


>gi|223718708 aflatoxin B1 aldehyde reductase 3 isoform 2 [Homo
           sapiens]
          Length = 249

 Score = 59.3 bits (142), Expect = 5e-09
 Identities = 41/144 (28%), Positives = 73/144 (50%), Gaps = 7/144 (4%)

Query: 48  GQITDEMAEQLMTLAY-DNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF 106
           G+  D      +T A+ + G    DTA +Y+ G++E +LG +  + G     + I TK  
Sbjct: 20  GRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKAN 79

Query: 107 -WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQ 165
            W G +     L    +   L+ SL+RLQ   VD+ + + PD + P+EET+RA   +  +
Sbjct: 80  PWIGNS-----LKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAPVEETLRACHQLHQE 134

Query: 166 GMAMYWGTSRWSSMEIMEAYSVAR 189
           G  +  G S +++ E+ E  ++ +
Sbjct: 135 GKFVELGLSNYAAWEVAEICTLCK 158


>gi|24497577 aldo-keto reductase family 1, member A1 [Homo sapiens]
          Length = 325

 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 50/200 (25%), Positives = 85/200 (42%), Gaps = 43/200 (21%)

Query: 31  SGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 90
           +G ++  +GLGTW +  GQ+     +  +  A   G    D A +Y     E  +G  +K
Sbjct: 10  TGQKMPLIGLGTWKSEPGQV-----KAAVKYALSVGYRHIDCAAIYGN---EPEIGEALK 61

Query: 91  K-----KGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 145
           +     K   R  L +T+K+ W  K   E       +   L+ +L  LQLEY+D+   + 
Sbjct: 62  EDVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 114

Query: 146 P-------DP------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 186
           P       +P            +T  +ET +A+  ++ +G+    G S ++S +I +  S
Sbjct: 115 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 174

Query: 187 VARQFNLTPPICEQAEYHMF 206
           VA       P   Q E H +
Sbjct: 175 VAS----VRPAVLQVECHPY 190


>gi|5174391 aldo-keto reductase family 1, member A1 [Homo sapiens]
          Length = 325

 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 50/200 (25%), Positives = 85/200 (42%), Gaps = 43/200 (21%)

Query: 31  SGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 90
           +G ++  +GLGTW +  GQ+     +  +  A   G    D A +Y     E  +G  +K
Sbjct: 10  TGQKMPLIGLGTWKSEPGQV-----KAAVKYALSVGYRHIDCAAIYGN---EPEIGEALK 61

Query: 91  K-----KGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 145
           +     K   R  L +T+K+ W  K   E       +   L+ +L  LQLEY+D+   + 
Sbjct: 62  EDVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 114

Query: 146 P-------DP------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 186
           P       +P            +T  +ET +A+  ++ +G+    G S ++S +I +  S
Sbjct: 115 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 174

Query: 187 VARQFNLTPPICEQAEYHMF 206
           VA       P   Q E H +
Sbjct: 175 VAS----VRPAVLQVECHPY 190


>gi|4502049 aldo-keto reductase family 1, member B1 [Homo sapiens]
          Length = 316

 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 42/179 (23%), Positives = 80/179 (44%), Gaps = 32/179 (17%)

Query: 23  MIYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYA-AGKA 81
           M  R L  +G ++  LGLGTW +  GQ+T     + + +A D G    D A VY    + 
Sbjct: 1   MASRLLLNNGAKMPILGLGTWKSPPGQVT-----EAVKVAIDVGYRHIDCAHVYQNENEV 55

Query: 82  EVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 141
            V +   ++++  +R  L I +K++       E+GL    +    + +L  L+L+Y+D+ 
Sbjct: 56  GVAIQEKLREQVVKREELFIVSKLWC---TYHEKGL----VKGACQKTLSDLKLDYLDLY 108

Query: 142 FANRPDPNTPMEE-------------------TVRAMTHVINQGMAMYWGTSRWSSMEI 181
             + P    P +E                   T  AM  ++++G+    G S ++ +++
Sbjct: 109 LIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQV 167


>gi|45446745 aldo-keto reductase family 1, member C2 [Homo sapiens]
          Length = 323

 Score = 38.1 bits (87), Expect = 0.012
 Identities = 44/199 (22%), Positives = 80/199 (40%), Gaps = 43/199 (21%)

Query: 38  LGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKK----G 93
           LG GT+     ++    A + + LA + G +  D+A VY     E  +G  I+ K     
Sbjct: 19  LGFGTYAP--AEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKIADGS 73

Query: 94  WRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPME 153
            +R  +  T+K+ W      E       +   L+ SL+ LQL+YVD+   + P    P E
Sbjct: 74  VKREDIFYTSKL-WSNSHRPEL------VRPALERSLKNLQLDYVDLYLIHFPVSVKPGE 126

Query: 154 ETVRAMTHVINQGMAMYWGT----SRWSSMEIMEAYSVARQFNLT--------------- 194
           E +       ++   + + T    + W +ME  +   +A+   ++               
Sbjct: 127 EVIPK-----DENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPG 181

Query: 195 ---PPICEQAEYHMFQREK 210
               P+C Q E H +  ++
Sbjct: 182 LKYKPVCNQVECHPYFNQR 200


>gi|4503285 aldo-keto reductase family 1, member C2 [Homo sapiens]
          Length = 323

 Score = 38.1 bits (87), Expect = 0.012
 Identities = 44/199 (22%), Positives = 80/199 (40%), Gaps = 43/199 (21%)

Query: 38  LGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKK----G 93
           LG GT+     ++    A + + LA + G +  D+A VY     E  +G  I+ K     
Sbjct: 19  LGFGTYAP--AEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKIADGS 73

Query: 94  WRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPME 153
            +R  +  T+K+ W      E       +   L+ SL+ LQL+YVD+   + P    P E
Sbjct: 74  VKREDIFYTSKL-WSNSHRPEL------VRPALERSLKNLQLDYVDLYLIHFPVSVKPGE 126

Query: 154 ETVRAMTHVINQGMAMYWGT----SRWSSMEIMEAYSVARQFNLT--------------- 194
           E +       ++   + + T    + W +ME  +   +A+   ++               
Sbjct: 127 EVIPK-----DENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPG 181

Query: 195 ---PPICEQAEYHMFQREK 210
               P+C Q E H +  ++
Sbjct: 182 LKYKPVCNQVECHPYFNQR 200


>gi|93277124 aldo-keto reductase family 1, member C-like 2 [Homo
           sapiens]
          Length = 320

 Score = 35.0 bits (79), Expect = 0.10
 Identities = 33/115 (28%), Positives = 53/115 (46%), Gaps = 17/115 (14%)

Query: 35  VSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLG--NIIKKK 92
           +  +GL +W    G++T+ + E     A D G   FD A  Y   + EV  G    IK+ 
Sbjct: 4   IPAVGLSSWKASPGKVTEAVKE-----AIDAGYRHFDCAYFY-HNEREVGAGIRCKIKEG 57

Query: 93  GWRRSSLVITTKIFWGGKAETERGLSRKHIIE-GLKASLERLQLEYVDVVFANRP 146
             RR  L I TK++            +K ++E   + SL+ L+L Y+D+   + P
Sbjct: 58  AVRREDLFIATKLWC--------TCHKKSLVETACRKSLKALKLNYLDLYLIHWP 104


>gi|5453543 aldo-keto reductase family 1, member C1 [Homo sapiens]
          Length = 323

 Score = 34.3 bits (77), Expect = 0.17
 Identities = 33/123 (26%), Positives = 53/123 (43%), Gaps = 16/123 (13%)

Query: 38  LGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKK----G 93
           LG GT+     ++    A +   LA + G    D+A +Y     E  +G  I+ K     
Sbjct: 19  LGFGTYAP--AEVPKSKALEATKLAIEAGFRHIDSAHLY---NNEEQVGLAIRSKIADGS 73

Query: 94  WRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPME 153
            +R  +  T+K+ W      E       +   L+ SL+ LQL+YVD+   + P    P E
Sbjct: 74  VKREDIFYTSKL-WCNSHRPEL------VRPALERSLKNLQLDYVDLYLIHFPVSVKPGE 126

Query: 154 ETV 156
           E +
Sbjct: 127 EVI 129


>gi|207028673 hypothetical protein LOC100134257 [Homo sapiens]
          Length = 139

 Score = 34.3 bits (77), Expect = 0.17
 Identities = 31/113 (27%), Positives = 51/113 (45%), Gaps = 16/113 (14%)

Query: 38  LGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKK----G 93
           LG GT+     ++    A + + LA + G +  D+A VY     E  +G  I+ K     
Sbjct: 19  LGFGTYAP--AEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKIADGS 73

Query: 94  WRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP 146
            +R  +  T+K+ W      E       +   L+ SL+ LQL+YVD+   + P
Sbjct: 74  VKREDIFYTSKL-WSNSHRPEL------VRPALERSLKNLQLDYVDLYLIHFP 119


>gi|24497583 aldo-keto reductase family 1, member C3 [Homo sapiens]
          Length = 323

 Score = 33.9 bits (76), Expect = 0.23
 Identities = 48/199 (24%), Positives = 79/199 (39%), Gaps = 40/199 (20%)

Query: 38  LGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKK----G 93
           LG GT+     ++    A ++  LA + G    D+A +Y     E  +G  I+ K     
Sbjct: 19  LGFGTYAP--PEVPRSKALEVTKLAIEAGFRHIDSAHLY---NNEEQVGLAIRSKIADGS 73

Query: 94  WRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPME 153
            +R  +  T+K+ W      E       +   L+ SL++ QL+YVD+   + P    P E
Sbjct: 74  VKREDIFYTSKL-WSTFHRPEL------VRPALENSLKKAQLDYVDLYLIHSPMSLKPGE 126

Query: 154 E-------------------TVRAMTHVINQGMAMYWGTSRWSSMEI-MEAYSVARQFNL 193
           E                   T  AM    + G+A   G S ++  ++ M       ++  
Sbjct: 127 ELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYK- 185

Query: 194 TPPICEQAEYH-MFQREKV 211
             P+C Q E H  F R K+
Sbjct: 186 --PVCNQVECHPYFNRSKL 202


>gi|24497585 aldo-keto reductase family 1, member C4 [Homo sapiens]
          Length = 323

 Score = 32.0 bits (71), Expect = 0.86
 Identities = 37/175 (21%), Positives = 74/175 (42%), Gaps = 29/175 (16%)

Query: 38  LGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKK----G 93
           LG GT+     ++    A ++  LA + G    D+A +Y     E  +G  I+ K     
Sbjct: 19  LGFGTYAP--PEVPRNRAVEVTKLAIEAGFRHIDSAYLY---NNEEQVGLAIRSKIADGS 73

Query: 94  WRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP------D 147
            +R  +  T+K++             + +   L++SL++LQL+YVD+   + P      +
Sbjct: 74  VKREDIFYTSKLWC-------TFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGE 126

Query: 148 PNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAE 202
              P +E  + +   ++        ++ W  ME  +   +A+   ++   C Q E
Sbjct: 127 TPLPKDENGKVIFDTVDL-------SATWEVMEKCKDAGLAKSIGVSNFNCRQLE 174


>gi|5174695 aldo-keto reductase family 1, member D1 [Homo sapiens]
          Length = 326

 Score = 30.0 bits (66), Expect = 3.3
 Identities = 49/202 (24%), Positives = 80/202 (39%), Gaps = 40/202 (19%)

Query: 32  GLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKK 91
           G  +  +GLGT+           A  +  +A D G    D A +Y   + E  +G  I++
Sbjct: 15  GNSIPIIGLGTYSEPKSTPKGACATSVK-VAIDTGYRHIDGAYIY---QNEHEVGEAIRE 70

Query: 92  KGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLER----LQLEYVDVVFANRP- 146
           K       V    IF+ GK       +  H+ E ++ +LER    LQL+YVD+     P 
Sbjct: 71  K--IAEGKVRREDIFYCGKL-----WATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPM 123

Query: 147 -----DPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQA 201
                D   P +E  + + H  N         + W +ME  +   + +   ++       
Sbjct: 124 AFKPGDEIYPRDENGKWLYHKSNL-------CATWEAMEACKDAGLVKSLGVS------- 169

Query: 202 EYHMFQREKVEVQL--PELFHK 221
               F R ++E+ L  P L HK
Sbjct: 170 ---NFNRRQLELILNKPGLKHK 188


>gi|58530886 interleukin-1 receptor-associated kinase 2 [Homo
           sapiens]
          Length = 625

 Score = 28.9 bits (63), Expect = 7.3
 Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 15/88 (17%)

Query: 192 NLTP----------PICEQAEYHMFQREKVEVQ---LPELFHKIGVGAMTWSPLACGIVS 238
           NLTP          P+ ++++Y M +   +      LPE F ++G         +CGIV 
Sbjct: 346 NLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVL 405

Query: 239 GKYDSGIPPYSRASLKGYQWLKDKILSE 266
            +  +GIP         Y  LKD +LS+
Sbjct: 406 AEVLTGIPAMDNNRSPVY--LKDLLLSD 431


>gi|55749758 DIP2 disco-interacting protein 2 homolog B [Homo
           sapiens]
          Length = 1576

 Score = 28.9 bits (63), Expect = 7.3
 Identities = 18/51 (35%), Positives = 25/51 (49%)

Query: 52  DEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVIT 102
           D   +Q+  L    GI L  T+EV   G  +   G I++ KGW R   V+T
Sbjct: 440 DAGGQQIGFLLGSCGIALALTSEVCLKGLPKTQNGEIVQFKGWPRLKWVVT 490


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,905,686
Number of Sequences: 37866
Number of extensions: 527996
Number of successful extensions: 1223
Number of sequences better than 10.0: 23
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1197
Number of HSP's gapped (non-prelim): 23
length of query: 353
length of database: 18,247,518
effective HSP length: 103
effective length of query: 250
effective length of database: 14,347,320
effective search space: 3586830000
effective search space used: 3586830000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.