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Search of human proteins with 27436957
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27436957 membrane associated guanylate kinase, WW and PDZ
domain containing 2 [Homo sapiens]
(1455 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 2980 0.0
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 1106 0.0
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 1103 0.0
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 973 0.0
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 973 0.0
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 973 0.0
gi|148746189 multiple PDZ domain protein [Homo sapiens] 109 2e-23
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 103 1e-21
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 103 1e-21
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 103 1e-21
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 99 2e-20
gi|112382257 InaD-like [Homo sapiens] 92 5e-18
gi|156546890 WW and C2 domain containing 2 [Homo sapiens] 88 5e-17
gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens] 86 3e-16
gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens] 86 3e-16
gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens] 86 3e-16
gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens] 86 3e-16
gi|45827729 scribble isoform b [Homo sapiens] 85 6e-16
gi|45827731 scribble isoform a [Homo sapiens] 85 6e-16
gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens] 85 6e-16
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 80 1e-14
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 79 4e-14
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 76 2e-13
gi|11141889 WW45 protein [Homo sapiens] 75 6e-13
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 74 1e-12
gi|87196343 PDZ domain containing 2 [Homo sapiens] 72 3e-12
gi|222352183 neural precursor cell expressed, developmentally do... 72 4e-12
gi|21361472 neural precursor cell expressed, developmentally dow... 72 4e-12
gi|222352094 neural precursor cell expressed, developmentally do... 72 4e-12
gi|222352092 neural precursor cell expressed, developmentally do... 72 4e-12
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 2980 bits (7725), Expect = 0.0
Identities = 1455/1455 (100%), Positives = 1455/1455 (100%)
Query: 1 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL 60
MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
Sbjct: 1 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL 60
Query: 61 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS 120
VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
Sbjct: 61 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS 120
Query: 121 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED 180
VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
Sbjct: 121 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED 180
Query: 181 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP 240
NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
Sbjct: 181 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP 240
Query: 241 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE 300
VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
Sbjct: 241 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE 300
Query: 301 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP 360
PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
Sbjct: 301 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP 360
Query: 361 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL 420
IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL
Sbjct: 361 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL 420
Query: 421 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC 480
KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC
Sbjct: 421 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC 480
Query: 481 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG 540
VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG
Sbjct: 481 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG 540
Query: 541 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ 600
RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ
Sbjct: 541 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ 600
Query: 601 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT 660
AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT
Sbjct: 601 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT 660
Query: 661 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP 720
EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP
Sbjct: 661 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP 720
Query: 721 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVH 780
PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVH
Sbjct: 721 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVH 780
Query: 781 LRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY 840
LRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY
Sbjct: 781 LRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY 840
Query: 841 VIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAA 900
VIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAA
Sbjct: 841 VIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAA 900
Query: 901 PSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDG 960
PSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDG
Sbjct: 901 PSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDG 960
Query: 961 SPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPS 1020
SPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPS
Sbjct: 961 SPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPS 1020
Query: 1021 SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVK 1080
SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVK
Sbjct: 1021 SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVK 1080
Query: 1081 PDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQP 1140
PDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQP
Sbjct: 1081 PDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQP 1140
Query: 1141 QDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGE 1200
QDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGE
Sbjct: 1141 QDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGE 1200
Query: 1201 STRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDD 1260
STRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDD
Sbjct: 1201 STRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDD 1260
Query: 1261 GLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASP 1320
GLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASP
Sbjct: 1261 GLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASP 1320
Query: 1321 QRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRR 1380
QRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRR
Sbjct: 1321 QRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRR 1380
Query: 1381 EGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSD 1440
EGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSD
Sbjct: 1381 EGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSD 1440
Query: 1441 KLPSVLKPGASAASR 1455
KLPSVLKPGASAASR
Sbjct: 1441 KLPSVLKPGASAASR 1455
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 1106 bits (2861), Expect = 0.0
Identities = 657/1427 (46%), Positives = 864/1427 (60%), Gaps = 178/1427 (12%)
Query: 1 MSKSLKKKSHWTSKVHESVIG-RNPEGQLGFELKGGAENGQFPYLGEVKP----GKVAYE 55
MSK+LKKK HW SKV E + P G G E++GGAE G+FPYLG ++ G
Sbjct: 1 MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVV 60
Query: 56 SGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLR 115
SG ++LLEVN TPV+GLT RD LAVI+H ++P+RLK VK G +++KDLRHYL+L+
Sbjct: 61 SGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQ 120
Query: 116 FQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLES 175
FQKGS+DH+LQQ+IRDNLYLRT+PCTTR ++GEVPGVDY FI+VE F LE+SGALLES
Sbjct: 121 FQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLES 180
Query: 176 GTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKA-SIEPPEE 234
GTY+ N+YGTPKPPAEP+P + DQ+L AE +RKR SVS ME+ S P EE
Sbjct: 181 GTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEE 240
Query: 235 EEEERPVVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTK 294
E+E++ +NG+G ++E+ ++ + +S M + P S + M D
Sbjct: 241 EDEDKEAINGSG------NAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRD----- 289
Query: 295 PEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGW 354
E +PLP NWEMAYT+ G +YFIDHNTKTT+WLDPRL KKAK PE+C++ ELPYGW
Sbjct: 290 ----ETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGW 345
Query: 355 EKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELG-TKPLQAPGFREKPLF 413
EKI+DP YGTYYVDH+N++TQFENPV EAKRK Q + E+G +KP EK F
Sbjct: 346 EKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQ---LGQVEIGSSKP-----DMEKSHF 397
Query: 414 TRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVI 473
TRD SQLKG + +LKKS MGFGFTIIGGD PDEFLQVK+V+ DGPAAQDGK+ GDVI
Sbjct: 398 TRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVI 457
Query: 474 VYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERP 533
V IN CVLGHTHADVV++FQ VP+ Q VNL LCRGYPLP D EDP +V +
Sbjct: 458 VDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPV---- 513
Query: 534 PPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSM 593
+NG+ + + + + ++ S H++ DG L+G P + VSM
Sbjct: 514 ----INGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDG-LNG--PSDASEQRVSM 566
Query: 594 ASSGATQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQN 653
ASSG++Q EL+T+ ++KG +GFGF IADSPTGQ+VK ILD Q C GL +GD+I EI QN
Sbjct: 567 ASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQN 626
Query: 654 VQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAI 713
VQNL+H +VV++LK P+G++ L+I RGG SP KT K D+ EN GS + +++ P I
Sbjct: 627 VQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLE-AINEP-I 684
Query: 714 PQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPD 773
PQ +PFPP++ RS P K DP E+Y KS+ +YE + PP T
Sbjct: 685 PQPMPFPPSIIRSGSP---------KLDPSEVYLKSKTLYEDK---PPNT---------- 722
Query: 774 YKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPV 833
K+LDV LR+ ESGFGFR+LGGD P Q I IGA+I +G+A++DGRL DEL+ +DGIPV
Sbjct: 723 -KDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPV 781
Query: 834 AGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATY 893
GK+H+ V+DLM AARNG V LTVRRK+ GE PE+ S +ST + SPR
Sbjct: 782 KGKSHKQVLDLMTTAARNGHVLLTVRRKIFY-GEKQPEDDSSQAFISTQNGSPR------ 834
Query: 894 TNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHK 953
N A + +P E + DVV+ RKENEGFGFVI++S N+P G +PHK
Sbjct: 835 --LNRAEVPARPAPQEPY--------DVVLQRKENEGFGFVILTSKNKPPPG---VIPHK 881
Query: 954 IGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELN 1013
IGR+I+GSPADRC KLKVGD I AVNGQSI+ + H +IV+LIKDAG++VTL +I +EE +
Sbjct: 882 IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHH 941
Query: 1014 SPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEV 1073
P S +S +QSP Q P+ Q Q + G ++ E+
Sbjct: 942 GPPSGTNSARQSPALQHRPMGQS---------------------QANHIPGDRSALEGEI 980
Query: 1074 KARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYP 1133
+DV T YR D++ PDT
Sbjct: 981 --GKDVS--------TSYRHSWSDHK-----------------------HLAQPDTAVIS 1007
Query: 1134 LSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQ 1193
+ R Q+ + V++E+G +GFGFS+RGG+EY M L++LRLAEDGPAI++GR+ VGDQ
Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQ 1067
Query: 1194 IIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPE---------------YDE- 1237
I+EINGE T+ +TH RAIELI++GG +V LLL+ GTG +P+ YDE
Sbjct: 1068 IVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDINNPSSSNVIYDEQ 1127
Query: 1238 -PAPWSSPAAA---APGLPEVGVSL-------DDGLAPFSPSHPAPPSDPSHQISPGPTW 1286
P P SS A+ +P + SL + L P + ++ +I
Sbjct: 1128 SPLPPSSHFASIFEESHVPVIEESLRVQICEKAEELKDIVPEKKSTLNENQPEIKHQSL- 1186
Query: 1287 DIKREHDVRKPKELSACGQKKQRLG-----EQRERSASPQRAARPRLEEAPGGQGRPEAG 1341
+++ R P KK L +R RS SP++ A EE P
Sbjct: 1187 -LQKNVSKRDPPSSHGHSNKKNLLKVENGVTRRGRSVSPKKPASQHSEEHLDKIPSPLKN 1245
Query: 1342 RPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRR-EGPGAAP 1387
P R L+ + + + + + RA +G + CR+ G A+P
Sbjct: 1246 NPKRRPRDQSLSPSKGENKS---CQVSTRAGSGQDQCRKSRGRSASP 1289
Score = 35.4 bits (80), Expect = 0.40
Identities = 11/30 (36%), Positives = 18/30 (60%)
Query: 1417 RPPGGAPARKAAVAPGPWKVPGSDKLPSVL 1446
+P +P +K + PGPWKVP +K+ +
Sbjct: 1445 KPESSSPVKKTLITPGPWKVPSGNKVTGTI 1474
>gi|155969695 membrane-associated guanylate kinase-related 3 isoform
2 [Homo sapiens]
Length = 1125
Score = 1103 bits (2853), Expect = 0.0
Identities = 618/1242 (49%), Positives = 802/1242 (64%), Gaps = 140/1242 (11%)
Query: 1 MSKSLKKKSHWTSKVHESVIG-RNPEGQLGFELKGGAENGQFPYLGEVKP----GKVAYE 55
MSK+LKKK HW SKV E + P G G E++GGAE G+FPYLG ++ G
Sbjct: 1 MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVV 60
Query: 56 SGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLR 115
SG ++LLEVN TPV+GLT RD LAVI+H ++P+RLK VK G +++KDLRHYL+L+
Sbjct: 61 SGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQ 120
Query: 116 FQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLES 175
FQKGS+DH+LQQ+IRDNLYLRT+PCTTR ++GEVPGVDY FI+VE F LE+SGALLES
Sbjct: 121 FQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLES 180
Query: 176 GTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKA-SIEPPEE 234
GTY+ N+YGTPKPPAEP+P + DQ+L AE +RKR SVS ME+ S P EE
Sbjct: 181 GTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEE 240
Query: 235 EEEERPVVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTK 294
E+E++ +NG+G ++E+ ++ + +S M + P S + M D
Sbjct: 241 EDEDKEAINGSG------NAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRD----- 289
Query: 295 PEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGW 354
E +PLP NWEMAYT+ G +YFIDHNTKTT+WLDPRL KKAK PE+C++ ELPYGW
Sbjct: 290 ----ETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGW 345
Query: 355 EKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELG-TKPLQAPGFREKPLF 413
EKI+DP YGTYYVDH+N++TQFENPV EAKRK Q + E+G +KP EK F
Sbjct: 346 EKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQ---LGQVEIGSSKP-----DMEKSHF 397
Query: 414 TRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVI 473
TRD SQLKG + +LKKS MGFGFTIIGGD PDEFLQVK+V+ DGPAAQDGK+ GDVI
Sbjct: 398 TRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVI 457
Query: 474 VYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERP 533
V IN CVLGHTHADVV++FQ VP+ Q VNL LCRGYPLP D EDP +V +
Sbjct: 458 VDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPV---- 513
Query: 534 PPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSM 593
+NG+ + + + + ++ S H++ DG L+G P + VSM
Sbjct: 514 ----INGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDG-LNG--PSDASEQRVSM 566
Query: 594 ASSGATQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQN 653
ASSG++Q EL+T+ ++KG +GFGF IADSPTGQ+VK ILD Q C GL +GD+I EI QN
Sbjct: 567 ASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQN 626
Query: 654 VQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAI 713
VQNL+H +VV++LK P+G++ L+I RGG SP KT K D+ EN GS + +++ P I
Sbjct: 627 VQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLE-AINEP-I 684
Query: 714 PQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPD 773
PQ +PFPP++ RS P K DP E+Y KS+ +YE + PP T
Sbjct: 685 PQPMPFPPSIIRSGSP---------KLDPSEVYLKSKTLYEDK---PPNT---------- 722
Query: 774 YKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPV 833
K+LDV LR+ ESGFGFR+LGGD P Q I IGA+I +G+A++DGRL DEL+ +DGIPV
Sbjct: 723 -KDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPV 781
Query: 834 AGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATY 893
GK+H+ V+DLM AARNG V LTVRRK+ GE PE+ S +ST + SPR
Sbjct: 782 KGKSHKQVLDLMTTAARNGHVLLTVRRKIFY-GEKQPEDDSSQAFISTQNGSPR------ 834
Query: 894 TNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHK 953
N A + +P E + DVV+ RKENEGFGFVI++S N+P G +PHK
Sbjct: 835 --LNRAEVPARPAPQEPY--------DVVLQRKENEGFGFVILTSKNKPPPG---VIPHK 881
Query: 954 IGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELN 1013
IGR+I+GSPADRC KLKVGD I AVNGQSI+ + H +IV+LIKDAG++VTL +I +EE +
Sbjct: 882 IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHH 941
Query: 1014 SPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEV 1073
P S +S +QSP Q P+ Q Q + G ++ E+
Sbjct: 942 GPPSGTNSARQSPALQHRPMGQS---------------------QANHIPGDRSALEGEI 980
Query: 1074 KARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYP 1133
+DV T YR D++ PDT
Sbjct: 981 --GKDVS--------TSYRHSWSDHK-----------------------HLAQPDTAVIS 1007
Query: 1134 LSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQ 1193
+ R Q+ + V++E+G +GFGFS+RGG+EY M L++LRLAEDGPAI++GR+ VGDQ
Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQ 1067
Query: 1194 IIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEY 1235
I+EINGE T+ +TH RAIELI++GG +V LLL+ GTG +P++
Sbjct: 1068 IVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDH 1109
Score = 107 bits (267), Expect = 8e-23
Identities = 146/668 (21%), Positives = 246/668 (36%), Gaps = 135/668 (20%)
Query: 659 HTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWE------------NQGSPQT 706
H+E D +K P ++T+ + + +T +P+ WE + + T
Sbjct: 260 HSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTT 319
Query: 707 SLSAPAIPQNLPFPPALHRSSFPDSTEAF-DPRKPDPYELYEKSRAIYESRQQVPPRTS- 764
+ P + + P P E DP+ Y + + +E+ + R
Sbjct: 320 TWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQ 379
Query: 765 ---FRMDSSGPDYKE--------------LDVHLRRMESGFGFRILGGDEPGQPILIGAV 807
+ SS PD ++ + L++ GFGF I+GGD P + + + V
Sbjct: 380 LGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNV 439
Query: 808 IAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGE 867
+ G A +DG++ PGD +V ++G V G TH V+ + N VNLT LC G
Sbjct: 440 LKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLT-----LCRGY 494
Query: 868 PCPENGRSP-----GSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVV 922
P P++ P + + + T N P + G + H+L +
Sbjct: 495 PLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLN 554
Query: 923 IHRKENEGFGFVIISSLNRPESGST--ITVPHKIGRIIDGSPADR----------CAKLK 970
+E + S ++PE + I P G I SP + C L+
Sbjct: 555 GPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQ 614
Query: 971 VGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQ 1030
GD I + Q++ N+ H +V+++K Q
Sbjct: 615 KGDIIKEIYHQNVQNLTHLQVVEVLK---------------------------------Q 641
Query: 1031 SPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQP-PFT 1089
P+ PL I + PP P + + + + + + I QP PF
Sbjct: 642 FPVGADVPLL----------ILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPF- 690
Query: 1090 DYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVD 1149
PP R G + P Y + L Y P+T+ D D F
Sbjct: 691 ----PPSIIRS---GSPKLDPSEVYLKSKTL-YEDKPPNTK-----------DLDVF--- 728
Query: 1150 MEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHAR 1209
+ K GFGF + GG +Y+ + G A ++GR+R D+++ I+G + +H +
Sbjct: 729 LRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQ 788
Query: 1210 AIELIKSGGRRVRLLL----KRGTGQ-VPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAP 1264
++L+ + R +LL K G+ PE D + S +P L V
Sbjct: 789 VLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEV-------- 840
Query: 1265 FSPSHPAP 1272
P+ PAP
Sbjct: 841 --PARPAP 846
Score = 67.0 bits (162), Expect = 1e-10
Identities = 75/289 (25%), Positives = 121/289 (41%), Gaps = 42/289 (14%)
Query: 610 KGAQGFGFTIADS----PTG---QRVKQILD---IQGCPGLCEGDLIVEINQQNVQNLSH 659
K +GFGF I S P G ++ ++++ C L GD I +N Q++ LSH
Sbjct: 857 KENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSH 916
Query: 660 TEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIP--QNL 717
+V ++KD + ++I E+ G P + SA P Q+
Sbjct: 917 DNIVQLIKDAGVTVTLTVIAEE-----------------EHHGPPSGTNSARQSPALQHR 959
Query: 718 PFPPALHRSSFPDSTEAFDPR-KPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKE 776
P + + P A + D Y S + ++ Q P T+ +
Sbjct: 960 PMGQS-QANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQ--PDTAVISVVGSRHNQN 1016
Query: 777 LD---VHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPV 833
L V L R GFGF + GG E + I + G A +DGR+H GD++V ++G P
Sbjct: 1017 LGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076
Query: 834 AGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTH 882
G TH I+L+ A +V L +R G P++G +P + ++
Sbjct: 1077 QGITHTRAIELIQ--AGGNKVLLLLRP----GTGLIPDHGLAPSGLCSY 1119
Score = 53.9 bits (128), Expect = 1e-06
Identities = 56/199 (28%), Positives = 86/199 (43%), Gaps = 14/199 (7%)
Query: 1150 MEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHAR 1209
++K GFGF+I GG L V + +DGPA ++G++ GD I++ING THA
Sbjct: 413 LKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHAD 472
Query: 1210 AIELIK--SGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSP 1267
+++ + + V L L RG +P+ D P AA P + G SL G +P
Sbjct: 473 VVQMFQLVPVNQYVNLTLCRGY-PLPD-DSEDPVVDIVAATPVIN--GQSLTKGETCMNP 528
Query: 1268 SHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPR 1327
P + Q G + + P + S +QR+ S+ P+ P
Sbjct: 529 QDFKPGAMVLEQ--NGKSGHTLTGDGLNGPSDAS-----EQRVSMASSGSSQPELVTIP- 580
Query: 1328 LEEAPGGQGRPEAGRPASE 1346
L + P G G A P +
Sbjct: 581 LIKGPKGFGFAIADSPTGQ 599
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 973 bits (2516), Expect = 0.0
Identities = 557/1124 (49%), Positives = 726/1124 (64%), Gaps = 121/1124 (10%)
Query: 1 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAY----ES 56
MSK ++KK+HWTS+VHE + R P+G+LG + GGAE+G+FPY+G V + A
Sbjct: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
Query: 57 GSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRF 116
G +L ELLLEV V+GL DVL VI CK+ + K V+QGG ++KDLRH+LN RF
Sbjct: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
Query: 117 QKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESG 176
QKGS DHELQQ IRDNLY VPCTTR +EGEVPGVDY F+TV++F++LE+SG LLE G
Sbjct: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
Query: 177 TYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPE-EE 235
TYE NYYGTPKPP++P + TD + + S + KR KS ++M+ A I E EE
Sbjct: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
Query: 236 EEERPVVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKP 295
E++ P +N + + E EH + A + S AP+ ++ + + P
Sbjct: 241 EDDVPEMNSSFTADSGEQEEHTLQET-ALPPVNSSIIAAPITDPSQKFPQYL----PLSA 295
Query: 296 EDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPR-LAKKAKPPEECKEN------ 348
EDN PLP+NWEMAYTE GEVYFIDHNTKTTSWLDPR L K+ KP EEC+++
Sbjct: 296 EDN--LGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTE 353
Query: 349 ------ELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRK---------------- 386
ELP GWEKI+DP+YG YYVDHINR+TQ+ENPVLEAKRK
Sbjct: 354 ELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQ 413
Query: 387 LQQHNMPHTELGT-------------------KPLQAPGFREKPLFTRDASQLKGTFLST 427
QQ TE T +P + + KP FTR+ S+LKG F+ T
Sbjct: 414 QQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHT 473
Query: 428 TLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHA 487
L+KS+ GFGFT++GGDEPDEFLQ+KS++ DGPAA DGKMETGDVIV +N+ CVLGHTHA
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 488 DVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETY 547
VVK+FQS+PIG SV+L LCRGYPLPFDP+DP S+V +AI+++ P++VNG+ Y++
Sbjct: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDK-EPIIVNGQETYDSP 592
Query: 548 LEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLT 607
+ S+T + V + D P S P D + ++ P +D VS+ASS ATQ EL+T+
Sbjct: 593 ASHSSKTGK-VNGMKDARP----SSPADVASNSSHGYP--NDTVSLASSIATQPELITVH 645
Query: 608 IVKGAQGFGFTIADSP--TGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDI 665
IVKG GFGFTIADSP GQRVKQI+D C GL EGDLIVE+N++NVQ L+H +VVD+
Sbjct: 646 IVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDM 705
Query: 666 LKDCPIGSETSLIIHRGGFFSPWKTPK-PIMDRWENQGSPQTSLSA-----PAIP----Q 715
L +CP GSE +L++ RGG P K+PK ++R ++Q S Q S+S+ A P Q
Sbjct: 706 LVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQ 765
Query: 716 NLP-FPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDY 774
LP FPPA + PD T++ +KPDP++++ +SR++YE+R PDY
Sbjct: 766 VLPEFPPA--EAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRL--------------PDY 809
Query: 775 KELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVA 834
+E D+ L R E+GFGFRILGG+EPG+PI IG ++ +G+AD DGRL GDEL+ VDG PV
Sbjct: 810 QEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVI 869
Query: 835 GKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSS--------- 885
GK+H+ V+ LM AA+ G VNLTVRRKV+ P EN P S+HHSS
Sbjct: 870 GKSHQLVVQLMQQAAKQGHVNLTVRRKVVF-AVPKTEN-EVPSPASSHHSSNQPASLTEE 927
Query: 886 PRSDYATYTNSNHAAPSSNASP--------PEGFASHSLQTSDVVIHRKENEGFGFVIIS 937
R+ + + N + S ++ G S +Q DV I R ENEGFGFVI+S
Sbjct: 928 KRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVS 987
Query: 938 SLNRPESGST-----ITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIV 992
S++RPE+G+T + +PHKIGRII+GSPADRC KLKVGDRILAVNG SI N H+DIV
Sbjct: 988 SVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIV 1047
Query: 993 KLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQ 1036
LIK+AG +VTLRIIP +E ++ T ++EK + + +QQ
Sbjct: 1048 NLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQ 1091
Score = 174 bits (442), Expect = 4e-43
Identities = 121/306 (39%), Positives = 153/306 (50%), Gaps = 25/306 (8%)
Query: 1131 QYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRV 1190
Q+ + Q+ D++TV++E+GAKGFGFS+RGGREY MDLYVLRLAEDGPA R G+MR+
Sbjct: 1107 QFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRI 1166
Query: 1191 GDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPG 1250
GD+I+EINGE+T++M H+RAIELIK+GGRRVRL LKRG G VPEYD + PA G
Sbjct: 1167 GDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQG 1226
Query: 1251 LPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRL 1310
+PEV P HP+ S + KR H R PK ++
Sbjct: 1227 VPEVRA------GPDRRQHPSLESSYPPDLHKSSPHGEKRAH-ARDPKGSREYSRQPNEH 1279
Query: 1311 GEQRERSASPQRAARPRLEEAPGGQGRPEAGRPAS---------EARAPGLAAADAADAA 1361
S P A + AP G+ +A R A+ E R G +AD
Sbjct: 1280 HTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRREGTRSADNTLER 1339
Query: 1362 RAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGG 1421
R K R E RRE +P G E R P R GG
Sbjct: 1340 RE--KHEKRRDVSPER-RRE---RSPTRRRDGSPSRRRRSLERLLEQRRSPE---RRRGG 1390
Query: 1422 APARKA 1427
+P R+A
Sbjct: 1391 SPERRA 1396
Score = 125 bits (314), Expect = 3e-28
Identities = 206/958 (21%), Positives = 355/958 (37%), Gaps = 151/958 (15%)
Query: 209 PSAEGKRKRNKSVSNMEKASIEPPEEEEEERPV---VNGNGVVVTPESSEHEDKSAGASG 265
P E KRK+ ++ + +++++++ + +V P H + +
Sbjct: 390 PVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAR 449
Query: 266 EMPSQPYPAPVYSQPEELKEQMDDTKPTKPE--------DNEEPDPLPDNWEMAYT---- 313
E+P Q P P ELK + TK K +EPD +
Sbjct: 450 EVPLQGKPF-FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAA 508
Query: 314 -----EKGEVYFIDHNTKTTSWLDPRLAK--------KAKPPEECKENELPYGWEKIDDP 360
E G+V ++T ++ K + E C+ LP+ DDP
Sbjct: 509 LDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFD---PDDP 565
Query: 361 ----IYGTYYVDH----INRRTQFENPVLEAKRKLQQHNM----PHTELGTKPLQAPGFR 408
+ +D +N + +++P + + + + M P + + G+
Sbjct: 566 NTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYP 625
Query: 409 EKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKME 468
+ + + ++ + K MGFGFTI D P Q I D P + ++
Sbjct: 626 NDTVSLASSIATQPELITVHIVKGPMGFGFTI--ADSPGGGGQRVKQIVDSPRCRG--LK 681
Query: 469 TGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLA 528
GD+IV +N+ V TH VV + P G V L++ RG LP + P + PL
Sbjct: 682 EGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRG-GLPVPKKSPKSQ---PLE 737
Query: 529 IMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHD 588
+ + + + S ++Q +P+ + + GQ P +
Sbjct: 738 RKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPD-PFKIWA 796
Query: 589 DNVSMASSGATQAELMTLTIVKGAQGFGFTI-ADSPTGQRVK-------QILDIQGCPGL 640
+ SM + + + + + GFGF I + G+ + D G L
Sbjct: 797 QSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDG--RL 854
Query: 641 CEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWEN 700
GD ++ ++ V SH VV +++ +L + R F+ KT EN
Sbjct: 855 RSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKT--------EN 906
Query: 701 QGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVP 760
+ +P P + H SS P L E+ R S+ +
Sbjct: 907 E---------------VPSPASSHHSS------------NQPASLTEEKRTPQGSQNSLN 939
Query: 761 PRTSFRMDSSGPD-------------YKELDVHLRRMES-GFGFRILGG---DEPG---- 799
+S +SG + DV +RR E+ GFGF I+ E G
Sbjct: 940 TVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFG 999
Query: 800 -----QPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQV 854
P IG +I ADR G+L GD ++ V+G + K+H +++L+ A
Sbjct: 1000 NACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGN---- 1055
Query: 855 NLTVRRKVLCGGEPCPE----NGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEG 910
TV +++ G E N +++T H+ S T N P S E
Sbjct: 1056 --TVTLRIIPGDESSNATLLTNAEKIATITTTHTP--SQQGTQETRNTTKPKQE-SQFEF 1110
Query: 911 FASHSLQTSDVVIHRKEN--EGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAK 968
A + Q D E +GFGF + G + + R+ + PA+RC K
Sbjct: 1111 KAPQATQEQDFYTVELERGAKGFGFSL-------RGGREYNMDLYVLRLAEDGPAERCGK 1163
Query: 969 LKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMA 1028
+++GD IL +NG++ NM H+ ++LIK+ G V L + + + + P PSS++ P
Sbjct: 1164 MRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRL-FLKRGDGSVPEYDPSSDRHGPAT 1222
Query: 1029 QQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQP 1086
Q P + P P + + P L R+ + + + RQP
Sbjct: 1223 G----PQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSRQP 1276
Score = 113 bits (282), Expect = 2e-24
Identities = 130/520 (25%), Positives = 206/520 (39%), Gaps = 121/520 (23%)
Query: 775 KELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVA 834
K + LR+ GFGF ++GGDEP + + I +++ G A DG++ GD +V V+ V
Sbjct: 469 KFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVL 528
Query: 835 GKTHRYVIDLMHHAARNGQVNLTVRRK------------------VLCGGEPCPENGRSP 876
G TH V+ + V+L + R + EP NG+
Sbjct: 529 GHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQET 588
Query: 877 GSVSTHHSS------------PRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIH 924
HSS P S +NS+H P+ S A+ Q + +H
Sbjct: 589 YDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIAT---QPELITVH 645
Query: 925 R-KENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSI 983
K GFGF I S P G ++ +I+D + RC LK GD I+ VN +++
Sbjct: 646 IVKGPMGFGFTIADS---PGGGG-----QRVKQIVD---SPRCRGLKEGDLIVEVNKKNV 694
Query: 984 INMPHADIVKLIKDA--GLSVTLRI------IPQEELNSPTSAPSSEKQSPMAQQSPLAQ 1035
+ H +V ++ + G VTL + +P++ SP S P K S + Q ++
Sbjct: 695 QALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKK---SPKSQPLERKDSQNSSQHSVSS 751
Query: 1036 QSPL--AQPSPAT---PNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTD 1090
L A PS +T P P A+ P G + KPD PF
Sbjct: 752 HRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQK-------------KPD----PFKI 794
Query: 1091 YRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDM 1150
+ Q Y L DY++ F +
Sbjct: 795 WAQSRSMYENR--------------------------------LPDYQEQDIF------L 816
Query: 1151 EKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARA 1210
+ GFGF I GG E +Y+ + G A +GR+R GD++I ++G +H
Sbjct: 817 WRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLV 876
Query: 1211 IELIKSGGRR--VRLLLKRG-TGQVPEYDEPAPWSSPAAA 1247
++L++ ++ V L ++R VP+ + P SPA++
Sbjct: 877 VQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVP--SPASS 914
Score = 66.6 bits (161), Expect = 2e-10
Identities = 108/456 (23%), Positives = 169/456 (37%), Gaps = 90/456 (19%)
Query: 925 RKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSII 984
RK + GFGF ++ + P+ I ++DG PA K++ GD I++VN ++
Sbjct: 476 RKSSRGFGFTVVGG-DEPDEFLQIK-----SLVLDG-PAALDGKMETGDVIVSVNDTCVL 528
Query: 985 NMPHADIVKLIKDA--GLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQP 1042
HA +VK+ + G SV L + L P++ + +A + + P+
Sbjct: 529 GHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVA----ILDKEPIIVN 584
Query: 1043 SPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPP 1102
T +SP + +S +V +D +P P D
Sbjct: 585 GQETYDSPASH-------------SSKTGKVNGMKDARPS-----------SPADVASNS 620
Query: 1103 GGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIR 1162
Y DT S QP+ TV + KG GFGF+I
Sbjct: 621 SHGYPN-------------------DTVSLASSIATQPE---LITVHIVKGPMGFGFTIA 658
Query: 1163 -----GGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKS- 1216
GG+ K + D P R ++ GD I+E+N ++ + +TH + ++++
Sbjct: 659 DSPGGGGQRVKQIV-------DSPRCRG--LKEGDLIVEVNKKNVQALTHNQVVDMLVEC 709
Query: 1217 -GGRRVRLLLKRGTGQVPEYDEPAPWSSPAAA--APGLPEVGVSLDDGLAPFSPSHPA-- 1271
G V LL++RG VP + +P S P + + VS L SPSH
Sbjct: 710 PKGSEVTLLVQRGGLPVP---KKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQV 766
Query: 1272 -PPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEE 1330
P P+ +P T +KP Q + + E R Q R E
Sbjct: 767 LPEFPPAEAQAPDQT----DSSGQKKPDPFKIWAQSRS-MYENRLPDYQEQDIFLWRKET 821
Query: 1331 APGGQ--GRPEAGRPASEARAPGLAAADAADAARAG 1364
G + G E G P L AAD R+G
Sbjct: 822 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSG 857
Score = 58.9 bits (141), Expect = 3e-08
Identities = 120/552 (21%), Positives = 191/552 (34%), Gaps = 103/552 (18%)
Query: 782 RRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDG-----RLHPGDELVYVDGIPVAGK 836
R + G +LGG E G+ +GAV A+ +A G RL G+ L+ V G+ V+G
Sbjct: 22 RGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGL 81
Query: 837 THRYVIDLMHH--------AARNG----------------------QVNLTVRRKVLCGG 866
V+ ++ A R G ++ T+R +
Sbjct: 82 PRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHA 141
Query: 867 EPC----PENGRSPGS----------VSTHHSSPRSDYATYTNSNHAAPSSNASPPEGF- 911
PC P G PG + S + TY + + P + P G
Sbjct: 142 VPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKV 201
Query: 912 ----ASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCA 967
A HSLQ+ K + + + + + E+ VP S
Sbjct: 202 ITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGEQEEH 261
Query: 968 KLKVGDRILAVNGQSIINMPHAD-IVKLIKDAGLSVTLRIIPQEE--------------L 1012
L+ + L SII P D K + LS + P E +
Sbjct: 262 TLQ--ETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFI 319
Query: 1013 NSPTSAPS-SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRS 1071
+ T S + + QQ PL + +S + PA + ++ + Y
Sbjct: 320 DHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVD 379
Query: 1072 EVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQ-------------PP 1118
+ K P R+ L+ +Q QQ +Q PP
Sbjct: 380 HINR----KTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPP 435
Query: 1119 LLDYRQHSPDT----RQYPLSDY----RQPQDFD--YFTVDMEKGAKGFGFSIRGGREYK 1168
++ H P R+ PL R P + + + K ++GFGF++ GG E
Sbjct: 436 VIP--NHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPD 493
Query: 1169 MDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKS--GGRRVRLLLK 1226
L + L DGPA +G+M GD I+ +N THA+ +++ +S G V L L
Sbjct: 494 EFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELC 553
Query: 1227 RGTGQVPEYDEP 1238
RG + D+P
Sbjct: 554 RGYPLPFDPDDP 565
Score = 45.1 bits (105), Expect = 5e-04
Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 13/96 (13%)
Query: 1146 FTVDMEKGA-KGFGFSIR------------GGREYKMDLYVLRLAEDGPAIRNGRMRVGD 1192
+ V++ +G +GFGF I G M + R+ E PA R G+++VGD
Sbjct: 969 YDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGD 1028
Query: 1193 QIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRG 1228
+I+ +NG S + +H+ + LIK G V L + G
Sbjct: 1029 RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPG 1064
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 973 bits (2516), Expect = 0.0
Identities = 560/1138 (49%), Positives = 732/1138 (64%), Gaps = 121/1138 (10%)
Query: 1 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAY----ES 56
MSK ++KK+HWTS+VHE + R P+G+LG + GGAE+G+FPY+G V + A
Sbjct: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
Query: 57 GSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRF 116
G +L ELLLEV V+GL DVL VI CK+ + K V+QGG ++KDLRH+LN RF
Sbjct: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
Query: 117 QKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESG 176
QKGS DHELQQ IRDNLY VPCTTR +EGEVPGVDY F+TV++F++LE+SG LLE G
Sbjct: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
Query: 177 TYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPE-EE 235
TYE NYYGTPKPP++P + TD + + S + KR KS ++M+ A I E EE
Sbjct: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
Query: 236 EEERPVVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKP 295
E++ P +N + + E EH + A + S AP+ ++ + + P
Sbjct: 241 EDDVPEMNSSFTADSGEQEEHTLQET-ALPPVNSSIIAAPITDPSQKFPQYL----PLSA 295
Query: 296 EDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPR-LAKKAKPPEECKEN------ 348
EDN PLP+NWEMAYTE GEVYFIDHNTKTTSWLDPR L K+ KP EEC+++
Sbjct: 296 EDN--LGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTE 353
Query: 349 ------ELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRK---------------- 386
ELP GWEKI+DP+YG YYVDHINR+TQ+ENPVLEAKRK
Sbjct: 354 ELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQ 413
Query: 387 LQQHNMPHTELGT-------------------KPLQAPGFREKPLFTRDASQLKGTFLST 427
QQ TE T +P + + KP FTR+ S+LKG F+ T
Sbjct: 414 QQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHT 473
Query: 428 TLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHA 487
L+KS+ GFGFT++GGDEPDEFLQ+KS++ DGPAA DGKMETGDVIV +N+ CVLGHTHA
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 488 DVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETY 547
VVK+FQS+PIG SV+L LCRGYPLPFDP+DP S+V +AI+++ P++VNG+ Y++
Sbjct: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDK-EPIIVNGQETYDSP 592
Query: 548 LEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLT 607
+ S+T + V + D P S P D + ++ P +D VS+ASS ATQ EL+T+
Sbjct: 593 ASHSSKTGK-VNGMKDARP----SSPADVASNSSHGYP--NDTVSLASSIATQPELITVH 645
Query: 608 IVKGAQGFGFTIADSP--TGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDI 665
IVKG GFGFTIADSP GQRVKQI+D C GL EGDLIVE+N++NVQ L+H +VVD+
Sbjct: 646 IVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDM 705
Query: 666 LKDCPIGSETSLIIHRGGFFSPWKTPK-PIMDRWENQGSPQTSLSA-----PAIP----Q 715
L +CP GSE +L++ RGG P K+PK ++R ++Q S Q S+S+ A P Q
Sbjct: 706 LVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQ 765
Query: 716 NLP-FPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTS--------FR 766
LP FPPA + PD T++ +KPDP++++ +SR++YE+R P S
Sbjct: 766 VLPEFPPA--EAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGERERE 823
Query: 767 MDSSG------PDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLH 820
++S+ PDY+E D+ L R E+GFGFRILGG+EPG+PI IG ++ +G+AD DGRL
Sbjct: 824 INSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLR 883
Query: 821 PGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVS 880
GDEL+ VDG PV GK+H+ V+ LM AA+ G VNLTVRRKV+ P EN P S
Sbjct: 884 SGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVF-AVPKTEN-EVPSPAS 941
Query: 881 THHSS---------PRSDYATYTNSNHAAPSSNASP--------PEGFASHSLQTSDVVI 923
+HHSS R+ + + N + S ++ G S +Q DV I
Sbjct: 942 SHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEI 1001
Query: 924 HRKENEGFGFVIISSLNRPESGST-----ITVPHKIGRIIDGSPADRCAKLKVGDRILAV 978
R ENEGFGFVI+SS++RPE+G+T + +PHKIGRII+GSPADRC KLKVGDRILAV
Sbjct: 1002 RRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAV 1061
Query: 979 NGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQ 1036
NG SI N H+DIV LIK+AG +VTLRIIP +E ++ T ++EK + + +QQ
Sbjct: 1062 NGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQ 1119
Score = 155 bits (391), Expect = 3e-37
Identities = 80/150 (53%), Positives = 103/150 (68%)
Query: 1131 QYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRV 1190
Q+ + Q+ D++TV++E+GAKGFGFS+RGGREY MDLYVLRLAEDGPA R G+MR+
Sbjct: 1135 QFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRI 1194
Query: 1191 GDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPG 1250
GD+I+EINGE+T++M H+RAIELIK+GGRRVRL LKRG G VPEY P +
Sbjct: 1195 GDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRNEK 1254
Query: 1251 LPEVGVSLDDGLAPFSPSHPAPPSDPSHQI 1280
L E L +P+ A P H++
Sbjct: 1255 LGEACFYLMGHNQTTTPAATATAPPPVHKV 1284
Score = 127 bits (319), Expect = 8e-29
Identities = 134/520 (25%), Positives = 215/520 (41%), Gaps = 93/520 (17%)
Query: 775 KELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVA 834
K + LR+ GFGF ++GGDEP + + I +++ G A DG++ GD +V V+ V
Sbjct: 469 KFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVL 528
Query: 835 GKTHRYVIDLMHHAARNGQVNLTVRRK------------------VLCGGEPCPENGRSP 876
G TH V+ + V+L + R + EP NG+
Sbjct: 529 GHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQET 588
Query: 877 GSVSTHHSS------------PRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIH 924
HSS P S +NS+H P+ S A+ Q + +H
Sbjct: 589 YDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIAT---QPELITVH 645
Query: 925 R-KENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSI 983
K GFGF I S P G ++ +I+D + RC LK GD I+ VN +++
Sbjct: 646 IVKGPMGFGFTIADS---PGGGG-----QRVKQIVD---SPRCRGLKEGDLIVEVNKKNV 694
Query: 984 INMPHADIVKLIKDA--GLSVTLRI------IPQEELNSPTSAPSSEKQSPMAQQSPLAQ 1035
+ H +V ++ + G VTL + +P++ SP S P K S + Q ++
Sbjct: 695 QALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKK---SPKSQPLERKDSQNSSQHSVSS 751
Query: 1036 QSPL--AQPSPAT---PNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTD 1090
L A PS +T P P A+ P G + KPD PF
Sbjct: 752 HRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQK-------------KPD----PFKI 794
Query: 1091 YRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDM 1150
+ Q Y P P P + +S + + P+ DY++ F +
Sbjct: 795 WAQSRSMYENRP----MSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIF------L 844
Query: 1151 EKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARA 1210
+ GFGF I GG E +Y+ + G A +GR+R GD++I ++G +H
Sbjct: 845 WRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLV 904
Query: 1211 IELIKSGGRR--VRLLLKRG-TGQVPEYDEPAPWSSPAAA 1247
++L++ ++ V L ++R VP+ + P SPA++
Sbjct: 905 VQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVP--SPASS 942
Score = 109 bits (273), Expect = 2e-23
Identities = 196/908 (21%), Positives = 333/908 (36%), Gaps = 182/908 (20%)
Query: 209 PSAEGKRKRNKSVSNMEKASIEPPEEEEEERPV---VNGNGVVVTPESSEHEDKSAGASG 265
P E KRK+ ++ + +++++++ + +V P H + +
Sbjct: 390 PVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAR 449
Query: 266 EMPSQPYPAPVYSQPEELKEQMDDTKPTKPE--------DNEEPDPLPDNWEMAYT---- 313
E+P Q P P ELK + TK K +EPD +
Sbjct: 450 EVPLQGKPF-FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAA 508
Query: 314 -----EKGEVYFIDHNTKTTSWLDPRLAK--------KAKPPEECKENELPYGWEKIDDP 360
E G+V ++T ++ K + E C+ LP+ DDP
Sbjct: 509 LDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFD---PDDP 565
Query: 361 ----IYGTYYVDH----INRRTQFENPVLEAKRKLQQHNM----PHTELGTKPLQAPGFR 408
+ +D +N + +++P + + + + M P + + G+
Sbjct: 566 NTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYP 625
Query: 409 EKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKME 468
+ + + ++ + K MGFGFTI D P Q I D P + ++
Sbjct: 626 NDTVSLASSIATQPELITVHIVKGPMGFGFTI--ADSPGGGGQRVKQIVDSPRCRG--LK 681
Query: 469 TGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLA 528
GD+IV +N+ V TH VV + P G V L++ RG LP + P +
Sbjct: 682 EGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRG-GLPVPKKSPKSQP----- 735
Query: 529 IMERPPPVMVNGRHNYETYLE-YISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPP--- 584
+ER + +H+ ++ + + S S + + PP + P G P
Sbjct: 736 -LERKDS-QNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQA-PDQTDSSGQKKPDPF 792
Query: 585 -------------PVHDDNVSMASSGATQAELMT---------------LTIVKGAQGFG 616
P+ S S G + E+ + + + + GFG
Sbjct: 793 KIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFG 852
Query: 617 FTI-ADSPTGQRVK-------QILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKD 668
F I + G+ + D G L GD ++ ++ V SH VV +++
Sbjct: 853 FRILGGNEPGEPIYIGHIVPLGAADTDG--RLRSGDELICVDGTPVIGKSHQLVVQLMQQ 910
Query: 669 CPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSF 728
+L + R F+ KT EN+ +P P + H SS
Sbjct: 911 AAKQGHVNLTVRRKVVFAVPKT--------ENE---------------VPSPASSHHSS- 946
Query: 729 PDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPD-------------YK 775
P L E+ R S+ + +S +SG +
Sbjct: 947 -----------NQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQ 995
Query: 776 ELDVHLRRMES-GFGFRILGG---DEPG---------QPILIGAVIAMGSADRDGRLHPG 822
DV +RR E+ GFGF I+ E G P IG +I ADR G+L G
Sbjct: 996 PYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVG 1055
Query: 823 DELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPE----NGRSPGS 878
D ++ V+G + K+H +++L+ A TV +++ G E N +
Sbjct: 1056 DRILAVNGCSITNKSHSDIVNLIKEAGN------TVTLRIIPGDESSNATLLTNAEKIAT 1109
Query: 879 VSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKEN--EGFGFVII 936
++T H+ S T N P S E A + Q D E +GFGF +
Sbjct: 1110 ITTTHTP--SQQGTQETRNTTKPKQE-SQFEFKAPQATQEQDFYTVELERGAKGFGFSL- 1165
Query: 937 SSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIK 996
G + + R+ + PA+RC K+++GD IL +NG++ NM H+ ++LIK
Sbjct: 1166 ------RGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIK 1219
Query: 997 DAGLSVTL 1004
+ G V L
Sbjct: 1220 NGGRRVRL 1227
Score = 58.9 bits (141), Expect = 3e-08
Identities = 120/552 (21%), Positives = 191/552 (34%), Gaps = 103/552 (18%)
Query: 782 RRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDG-----RLHPGDELVYVDGIPVAGK 836
R + G +LGG E G+ +GAV A+ +A G RL G+ L+ V G+ V+G
Sbjct: 22 RGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGL 81
Query: 837 THRYVIDLMHH--------AARNG----------------------QVNLTVRRKVLCGG 866
V+ ++ A R G ++ T+R +
Sbjct: 82 PRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHA 141
Query: 867 EPC----PENGRSPGS----------VSTHHSSPRSDYATYTNSNHAAPSSNASPPEGF- 911
PC P G PG + S + TY + + P + P G
Sbjct: 142 VPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKV 201
Query: 912 ----ASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCA 967
A HSLQ+ K + + + + + E+ VP S
Sbjct: 202 ITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGEQEEH 261
Query: 968 KLKVGDRILAVNGQSIINMPHAD-IVKLIKDAGLSVTLRIIPQEE--------------L 1012
L+ + L SII P D K + LS + P E +
Sbjct: 262 TLQ--ETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFI 319
Query: 1013 NSPTSAPS-SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRS 1071
+ T S + + QQ PL + +S + PA + ++ + Y
Sbjct: 320 DHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVD 379
Query: 1072 EVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQ-------------PP 1118
+ K P R+ L+ +Q QQ +Q PP
Sbjct: 380 HINR----KTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPP 435
Query: 1119 LLDYRQHSPDT----RQYPLSDY----RQPQDFD--YFTVDMEKGAKGFGFSIRGGREYK 1168
++ H P R+ PL R P + + + K ++GFGF++ GG E
Sbjct: 436 VIP--NHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPD 493
Query: 1169 MDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKS--GGRRVRLLLK 1226
L + L DGPA +G+M GD I+ +N THA+ +++ +S G V L L
Sbjct: 494 EFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELC 553
Query: 1227 RGTGQVPEYDEP 1238
RG + D+P
Sbjct: 554 RGYPLPFDPDDP 565
Score = 58.2 bits (139), Expect = 6e-08
Identities = 46/139 (33%), Positives = 65/139 (46%), Gaps = 13/139 (9%)
Query: 389 QHNMPHTELGTKPLQAPGFREK-PLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPD 447
Q T TKP Q F K P T++ F + L++ GFGF++ GG E +
Sbjct: 1118 QQGTQETRNTTKPKQESQFEFKAPQATQEQD-----FYTVELERGAKGFGFSLRGGREYN 1172
Query: 448 EFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLC 507
L V + DGPA + GKM GD I+ IN H+ ++L ++ G+ V L L
Sbjct: 1173 MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNG--GRRVRLFLK 1230
Query: 508 RGYPLPFDPEDPANSMVPP 526
RG D P +M+PP
Sbjct: 1231 RG-----DGSVPEYAMIPP 1244
Score = 50.8 bits (120), Expect = 9e-06
Identities = 57/269 (21%), Positives = 104/269 (38%), Gaps = 61/269 (22%)
Query: 433 NMGFGFTIIGGDEPDEF------------LQVKSVIPDGPAAQDGKMETGDVIVYINEVC 480
N GFGF I+ E ++ +I PA + GK++ GD I+ +N
Sbjct: 1006 NEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCS 1065
Query: 481 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG 540
+ +H+D+V L + G +V L + +P D A +
Sbjct: 1066 ITNKSHSDIVNLIKEA--GNTVTLRI-----IPGDESSNATLLT---------------- 1102
Query: 541 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ 600
++ + IT H+ T + T P + + ATQ
Sbjct: 1103 -------------NAEKIATITTT--HTPSQQGTQETRNTTKPK--QESQFEFKAPQATQ 1145
Query: 601 AE-LMTLTIVKGAQGFGFTIADSPTGQRVKQILDI------QGCPGLCEGDLIVEINQQN 653
+ T+ + +GA+GFGF++ +L + + C + GD I+EIN +
Sbjct: 1146 EQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGET 1205
Query: 654 VQNLSHTEVVDILKDCPIGSETSLIIHRG 682
+N+ H+ ++++K+ G L + RG
Sbjct: 1206 TKNMKHSRAIELIKNG--GRRVRLFLKRG 1232
Score = 45.1 bits (105), Expect = 5e-04
Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 13/96 (13%)
Query: 1146 FTVDMEKGA-KGFGFSIR------------GGREYKMDLYVLRLAEDGPAIRNGRMRVGD 1192
+ V++ +G +GFGF I G M + R+ E PA R G+++VGD
Sbjct: 997 YDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGD 1056
Query: 1193 QIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRG 1228
+I+ +NG S + +H+ + LIK G V L + G
Sbjct: 1057 RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPG 1092
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 973 bits (2515), Expect = 0.0
Identities = 560/1139 (49%), Positives = 732/1139 (64%), Gaps = 122/1139 (10%)
Query: 1 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAY----ES 56
MSK ++KK+HWTS+VHE + R P+G+LG + GGAE+G+FPY+G V + A
Sbjct: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
Query: 57 GSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRF 116
G +L ELLLEV V+GL DVL VI CK+ + K V+QGG ++KDLRH+LN RF
Sbjct: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
Query: 117 QKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESG 176
QKGS DHELQQ IRDNLY VPCTTR +EGEVPGVDY F+TV++F++LE+SG LLE G
Sbjct: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
Query: 177 TYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPE-EE 235
TYE NYYGTPKPP++P + TD + + S + KR KS ++M+ A I E EE
Sbjct: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
Query: 236 EEERPVVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKP 295
E++ P +N + + E EH + A + S AP+ ++ + + P
Sbjct: 241 EDDVPEMNSSFTADSGEQEEHTLQET-ALPPVNSSIIAAPITDPSQKFPQYL----PLSA 295
Query: 296 EDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPR-LAKKAKPPEECKEN------ 348
EDN PLP+NWEMAYTE GEVYFIDHNTKTTSWLDPR L K+ KP EEC+++
Sbjct: 296 EDN--LGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTE 353
Query: 349 ------ELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRK---------------- 386
ELP GWEKI+DP+YG YYVDHINR+TQ+ENPVLEAKRK
Sbjct: 354 ELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQ 413
Query: 387 LQQHNMPHTELGT-------------------KPLQAPGFREKPLFTRDASQLKGTFLST 427
QQ TE T +P + + KP FTR+ S+LKG F+ T
Sbjct: 414 QQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHT 473
Query: 428 TLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHA 487
L+KS+ GFGFT++GGDEPDEFLQ+KS++ DGPAA DGKMETGDVIV +N+ CVLGHTHA
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 488 DVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETY 547
VVK+FQS+PIG SV+L LCRGYPLPFDP+DP S+V +AI+++ P++VNG+ Y++
Sbjct: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDK-EPIIVNGQETYDSP 592
Query: 548 LEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLT 607
+ S+T + V + D P S P D + ++ P +D VS+ASS ATQ EL+T+
Sbjct: 593 ASHSSKTGK-VNGMKDARP----SSPADVASNSSHGYP--NDTVSLASSIATQPELITVH 645
Query: 608 IVKGAQGFGFTIADSP--TGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDI 665
IVKG GFGFTIADSP GQRVKQI+D C GL EGDLIVE+N++NVQ L+H +VVD+
Sbjct: 646 IVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDM 705
Query: 666 LKDCPIGSETSLIIHRGGFFSPWKTPK-PIMDRWENQGSPQTSLSA-----PAIP----Q 715
L +CP GSE +L++ RGG P K+PK ++R ++Q S Q S+S+ A P Q
Sbjct: 706 LVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQ 765
Query: 716 NLP-FPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTS--------FR 766
LP FPPA + PD T++ +KPDP++++ +SR++YE+R P S
Sbjct: 766 VLPEFPPA--EAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGERERE 823
Query: 767 MDSSG------PDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLH 820
++S+ PDY+E D+ L R E+GFGFRILGG+EPG+PI IG ++ +G+AD DGRL
Sbjct: 824 INSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLR 883
Query: 821 PGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVS 880
GDEL+ VDG PV GK+H+ V+ LM AA+ G VNLTVRRKV+ P EN P S
Sbjct: 884 SGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVF-AVPKTEN-EVPSPAS 941
Query: 881 THHSS---------PRSDYATYTNSNHAAPSSNASP--------PEGFASHSLQTSDVVI 923
+HHSS R+ + + N + S ++ G S +Q DV I
Sbjct: 942 SHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEI 1001
Query: 924 HRKENEGFGFVIISSLNRPESGST------ITVPHKIGRIIDGSPADRCAKLKVGDRILA 977
R ENEGFGFVI+SS++RPE+G+T + +PHKIGRII+GSPADRC KLKVGDRILA
Sbjct: 1002 RRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILA 1061
Query: 978 VNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQ 1036
VNG SI N H+DIV LIK+AG +VTLRIIP +E ++ T ++EK + + +QQ
Sbjct: 1062 VNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQ 1120
Score = 154 bits (390), Expect = 5e-37
Identities = 72/105 (68%), Positives = 90/105 (85%)
Query: 1131 QYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRV 1190
Q+ + Q+ D++TV++E+GAKGFGFS+RGGREY MDLYVLRLAEDGPA R G+MR+
Sbjct: 1136 QFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRI 1195
Query: 1191 GDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEY 1235
GD+I+EINGE+T++M H+RAIELIK+GGRRVRL LKRG G VPEY
Sbjct: 1196 GDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEY 1240
Score = 127 bits (319), Expect = 8e-29
Identities = 134/520 (25%), Positives = 215/520 (41%), Gaps = 93/520 (17%)
Query: 775 KELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVA 834
K + LR+ GFGF ++GGDEP + + I +++ G A DG++ GD +V V+ V
Sbjct: 469 KFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVL 528
Query: 835 GKTHRYVIDLMHHAARNGQVNLTVRRK------------------VLCGGEPCPENGRSP 876
G TH V+ + V+L + R + EP NG+
Sbjct: 529 GHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQET 588
Query: 877 GSVSTHHSS------------PRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIH 924
HSS P S +NS+H P+ S A+ Q + +H
Sbjct: 589 YDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIAT---QPELITVH 645
Query: 925 R-KENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSI 983
K GFGF I S P G ++ +I+D + RC LK GD I+ VN +++
Sbjct: 646 IVKGPMGFGFTIADS---PGGGG-----QRVKQIVD---SPRCRGLKEGDLIVEVNKKNV 694
Query: 984 INMPHADIVKLIKDA--GLSVTLRI------IPQEELNSPTSAPSSEKQSPMAQQSPLAQ 1035
+ H +V ++ + G VTL + +P++ SP S P K S + Q ++
Sbjct: 695 QALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKK---SPKSQPLERKDSQNSSQHSVSS 751
Query: 1036 QSPL--AQPSPAT---PNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTD 1090
L A PS +T P P A+ P G + KPD PF
Sbjct: 752 HRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQK-------------KPD----PFKI 794
Query: 1091 YRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDM 1150
+ Q Y P P P + +S + + P+ DY++ F +
Sbjct: 795 WAQSRSMYENRP----MSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIF------L 844
Query: 1151 EKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARA 1210
+ GFGF I GG E +Y+ + G A +GR+R GD++I ++G +H
Sbjct: 845 WRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLV 904
Query: 1211 IELIKSGGRR--VRLLLKRG-TGQVPEYDEPAPWSSPAAA 1247
++L++ ++ V L ++R VP+ + P SPA++
Sbjct: 905 VQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVP--SPASS 942
Score = 109 bits (272), Expect = 2e-23
Identities = 196/909 (21%), Positives = 333/909 (36%), Gaps = 183/909 (20%)
Query: 209 PSAEGKRKRNKSVSNMEKASIEPPEEEEEERPV---VNGNGVVVTPESSEHEDKSAGASG 265
P E KRK+ ++ + +++++++ + +V P H + +
Sbjct: 390 PVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAR 449
Query: 266 EMPSQPYPAPVYSQPEELKEQMDDTKPTKPE--------DNEEPDPLPDNWEMAYT---- 313
E+P Q P P ELK + TK K +EPD +
Sbjct: 450 EVPLQGKPF-FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAA 508
Query: 314 -----EKGEVYFIDHNTKTTSWLDPRLAK--------KAKPPEECKENELPYGWEKIDDP 360
E G+V ++T ++ K + E C+ LP+ DDP
Sbjct: 509 LDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFD---PDDP 565
Query: 361 ----IYGTYYVDH----INRRTQFENPVLEAKRKLQQHNM----PHTELGTKPLQAPGFR 408
+ +D +N + +++P + + + + M P + + G+
Sbjct: 566 NTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYP 625
Query: 409 EKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKME 468
+ + + ++ + K MGFGFTI D P Q I D P + ++
Sbjct: 626 NDTVSLASSIATQPELITVHIVKGPMGFGFTI--ADSPGGGGQRVKQIVDSPRCRG--LK 681
Query: 469 TGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLA 528
GD+IV +N+ V TH VV + P G V L++ RG LP + P +
Sbjct: 682 EGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRG-GLPVPKKSPKSQP----- 735
Query: 529 IMERPPPVMVNGRHNYETYLE-YISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPP--- 584
+ER + +H+ ++ + + S S + + PP + P G P
Sbjct: 736 -LERKDS-QNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQA-PDQTDSSGQKKPDPF 792
Query: 585 -------------PVHDDNVSMASSGATQAELMT---------------LTIVKGAQGFG 616
P+ S S G + E+ + + + + GFG
Sbjct: 793 KIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFG 852
Query: 617 FTI-ADSPTGQRVK-------QILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKD 668
F I + G+ + D G L GD ++ ++ V SH VV +++
Sbjct: 853 FRILGGNEPGEPIYIGHIVPLGAADTDG--RLRSGDELICVDGTPVIGKSHQLVVQLMQQ 910
Query: 669 CPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSF 728
+L + R F+ KT EN+ +P P + H SS
Sbjct: 911 AAKQGHVNLTVRRKVVFAVPKT--------ENE---------------VPSPASSHHSS- 946
Query: 729 PDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPD-------------YK 775
P L E+ R S+ + +S +SG +
Sbjct: 947 -----------NQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQ 995
Query: 776 ELDVHLRRMES-GFGFRILGG---DEPG----------QPILIGAVIAMGSADRDGRLHP 821
DV +RR E+ GFGF I+ E G P IG +I ADR G+L
Sbjct: 996 PYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKV 1055
Query: 822 GDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPE----NGRSPG 877
GD ++ V+G + K+H +++L+ A TV +++ G E N
Sbjct: 1056 GDRILAVNGCSITNKSHSDIVNLIKEAGN------TVTLRIIPGDESSNATLLTNAEKIA 1109
Query: 878 SVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKEN--EGFGFVI 935
+++T H+ S T N P S E A + Q D E +GFGF +
Sbjct: 1110 TITTTHTP--SQQGTQETRNTTKPKQE-SQFEFKAPQATQEQDFYTVELERGAKGFGFSL 1166
Query: 936 ISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLI 995
G + + R+ + PA+RC K+++GD IL +NG++ NM H+ ++LI
Sbjct: 1167 -------RGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELI 1219
Query: 996 KDAGLSVTL 1004
K+ G V L
Sbjct: 1220 KNGGRRVRL 1228
Score = 58.9 bits (141), Expect = 3e-08
Identities = 120/552 (21%), Positives = 191/552 (34%), Gaps = 103/552 (18%)
Query: 782 RRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDG-----RLHPGDELVYVDGIPVAGK 836
R + G +LGG E G+ +GAV A+ +A G RL G+ L+ V G+ V+G
Sbjct: 22 RGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGL 81
Query: 837 THRYVIDLMHH--------AARNG----------------------QVNLTVRRKVLCGG 866
V+ ++ A R G ++ T+R +
Sbjct: 82 PRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHA 141
Query: 867 EPC----PENGRSPGS----------VSTHHSSPRSDYATYTNSNHAAPSSNASPPEGF- 911
PC P G PG + S + TY + + P + P G
Sbjct: 142 VPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKV 201
Query: 912 ----ASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCA 967
A HSLQ+ K + + + + + E+ VP S
Sbjct: 202 ITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGEQEEH 261
Query: 968 KLKVGDRILAVNGQSIINMPHAD-IVKLIKDAGLSVTLRIIPQEE--------------L 1012
L+ + L SII P D K + LS + P E +
Sbjct: 262 TLQ--ETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFI 319
Query: 1013 NSPTSAPS-SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRS 1071
+ T S + + QQ PL + +S + PA + ++ + Y
Sbjct: 320 DHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVD 379
Query: 1072 EVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQ-------------PP 1118
+ K P R+ L+ +Q QQ +Q PP
Sbjct: 380 HINR----KTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPP 435
Query: 1119 LLDYRQHSPDT----RQYPLSDY----RQPQDFD--YFTVDMEKGAKGFGFSIRGGREYK 1168
++ H P R+ PL R P + + + K ++GFGF++ GG E
Sbjct: 436 VIP--NHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPD 493
Query: 1169 MDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKS--GGRRVRLLLK 1226
L + L DGPA +G+M GD I+ +N THA+ +++ +S G V L L
Sbjct: 494 EFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELC 553
Query: 1227 RGTGQVPEYDEP 1238
RG + D+P
Sbjct: 554 RGYPLPFDPDDP 565
Score = 53.5 bits (127), Expect = 1e-06
Identities = 41/122 (33%), Positives = 58/122 (47%), Gaps = 8/122 (6%)
Query: 389 QHNMPHTELGTKPLQAPGFREK-PLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPD 447
Q T TKP Q F K P T++ F + L++ GFGF++ GG E +
Sbjct: 1119 QQGTQETRNTTKPKQESQFEFKAPQATQEQD-----FYTVELERGAKGFGFSLRGGREYN 1173
Query: 448 EFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLC 507
L V + DGPA + GKM GD I+ IN H+ ++L ++ G+ V L L
Sbjct: 1174 MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNG--GRRVRLFLK 1231
Query: 508 RG 509
RG
Sbjct: 1232 RG 1233
Score = 50.4 bits (119), Expect = 1e-05
Identities = 57/270 (21%), Positives = 104/270 (38%), Gaps = 62/270 (22%)
Query: 433 NMGFGFTIIGGDEPDEF-------------LQVKSVIPDGPAAQDGKMETGDVIVYINEV 479
N GFGF I+ E ++ +I PA + GK++ GD I+ +N
Sbjct: 1006 NEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGC 1065
Query: 480 CVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVN 539
+ +H+D+V L + G +V L + +P D A +
Sbjct: 1066 SITNKSHSDIVNLIKEA--GNTVTLRI-----IPGDESSNATLLT--------------- 1103
Query: 540 GRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGAT 599
++ + IT H+ T + T P + + AT
Sbjct: 1104 --------------NAEKIATITTT--HTPSQQGTQETRNTTKPK--QESQFEFKAPQAT 1145
Query: 600 QAE-LMTLTIVKGAQGFGFTIADSPTGQRVKQILDI------QGCPGLCEGDLIVEINQQ 652
Q + T+ + +GA+GFGF++ +L + + C + GD I+EIN +
Sbjct: 1146 QEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGE 1205
Query: 653 NVQNLSHTEVVDILKDCPIGSETSLIIHRG 682
+N+ H+ ++++K+ G L + RG
Sbjct: 1206 TTKNMKHSRAIELIKNG--GRRVRLFLKRG 1233
Score = 45.4 bits (106), Expect = 4e-04
Identities = 30/97 (30%), Positives = 48/97 (49%), Gaps = 14/97 (14%)
Query: 1146 FTVDMEKGA-KGFGFSI-------------RGGREYKMDLYVLRLAEDGPAIRNGRMRVG 1191
+ V++ +G +GFGF I G M + R+ E PA R G+++VG
Sbjct: 997 YDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVG 1056
Query: 1192 DQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRG 1228
D+I+ +NG S + +H+ + LIK G V L + G
Sbjct: 1057 DRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPG 1093
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 109 bits (272), Expect = 2e-23
Identities = 167/837 (19%), Positives = 325/837 (38%), Gaps = 136/837 (16%)
Query: 429 LKKSNMGFGFTIIGGDEPDE----FLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGH 484
L+K + G GF+I+ +P + + ++S++P G A +DG++ GD ++++N+V +
Sbjct: 703 LEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENS 762
Query: 485 THADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNY 544
+ + V+ + P G +V + + + PLP PE+ S + + P G +
Sbjct: 763 SLEEAVEALKGAPSG-TVRIGVAK--PLPLSPEEGYVSAKED-SFLYPPHSCEEAGLADK 818
Query: 545 ETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELM 604
+ ++ + D+ D + T+ P +N S+ S TQA ++
Sbjct: 819 PLFRADLALVGTNDADLVD---------------ESTFESPYSPENDSIYS---TQASIL 860
Query: 605 TLTIVKGAQG--FGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNL----- 657
+L G +G ++ SP K +++ P L DL + + + QNL
Sbjct: 861 SLHGSSCGDGLNYGSSLPSSPP----KDVIENSCDPVL---DLHMSLEELYTQNLLQRQD 913
Query: 658 SHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNL 717
+T VDI G + ++ I+ W P +S+ +P
Sbjct: 914 ENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIV--WTESHLPSEVISSAELP--- 968
Query: 718 PFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKEL 777
S PDS K Y L + S A + + + E
Sbjct: 969 --------SVLPDSAG-----KGSEYLLEQSSLACNAE--------CVMLQNVSKESFER 1007
Query: 778 DVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKT 837
+++ + S G + ++ G +++ ++I G+ RDGR+ GD ++ ++ T
Sbjct: 1008 TINIAKGNSSLGMTV-SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVT 1066
Query: 838 HRYVIDLMHHAARNGQVNLTVRRKVLCGGEP----CPENGRSPGSVSTHHSSPR----SD 889
N Q +RR L G + P +S S R
Sbjct: 1067 -------------NAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDI 1113
Query: 890 YATYTNSN-------HAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVII------ 936
+++YT + + S+ Q V + R+ ++ G I+
Sbjct: 1114 FSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMG 1173
Query: 937 SSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIK 996
S L+ E I + H +++ SPA + LK GDRI+ V+G + + H V+ I+
Sbjct: 1174 SRLSNGEVMRGIFIKH----VLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIR 1229
Query: 997 DAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAP 1056
AG V + Q +N P +P + + + +P A
Sbjct: 1230 KAGNPVVFMV--QSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADS-------------- 1273
Query: 1057 PQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQ 1116
LQ+ + +SE + + + PP + + + D+ Q Q D +
Sbjct: 1274 ---LQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQ----DVDK 1326
Query: 1117 PPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREY-KMDLYVLR 1175
Y + R L+ + +++EKG G G S+ G ++ +M ++++
Sbjct: 1327 EDEFGYSWKNIRERYGTLTG-------ELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVG 1379
Query: 1176 LAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQV 1232
+ +G A ++GR+++ D+++EING+ +H A +IK +V+++ R V
Sbjct: 1380 IDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAV 1436
Score = 103 bits (257), Expect = 1e-21
Identities = 182/838 (21%), Positives = 333/838 (39%), Gaps = 106/838 (12%)
Query: 429 LKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHAD 488
+ K N G T+ + + V+S+I G ++DG++ GD I+ INE + T+A
Sbjct: 1011 IAKGNSSLGMTVSANKDGLGMI-VRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQ 1069
Query: 489 V-VKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVP-PLAIMERPPPVMVNGRHNYET 546
L + IG + + PA + +++ ++ VM +
Sbjct: 1070 ARAMLRRHSLIGPDIKITYV-----------PAEHLEEFKISLGQQSGRVMA-----LDI 1113
Query: 547 YLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTL 606
+ Y T + +P++ +R + P ++ + +
Sbjct: 1114 FSSY---TGRDIPELPEREEGEGEESELQNTAYSNWNQP------RRVELWREPSKSLGI 1164
Query: 607 TIVKGAQGFGFTIADSPT--GQRVKQILDIQ--GCPG-LCEGDLIVEINQQNVQNLSHTE 661
+IV G +G G +++ G +K +L+ G G L GD IVE++ ++++ SH +
Sbjct: 1165 SIV-GGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQ 1223
Query: 662 VVDILKDC--PIGSETSLIIHRGGFFSPWKTPKPIM--DRWENQGSPQTSLSAPAIPQNL 717
V+ ++ P+ II+R P K+P P + + + T+ A ++ N
Sbjct: 1224 AVEAIRKAGNPVVFMVQSIINR-----PRKSPLPSLLHNLYPKYNFSSTNPFADSLQINA 1278
Query: 718 PFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKEL 777
P+ S P+ P P E +S + + D G +K +
Sbjct: 1279 DKAPSQSESE-PEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNI 1337
Query: 778 ---------DVHLRRME---SGFGFRILGG-DEPGQPILIGAVIAMGSADRDGRLHPGDE 824
++H+ +E SG G + G D + I + G+A +DGRL DE
Sbjct: 1338 RERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADE 1397
Query: 825 LVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHS 884
L+ ++G + G++H+ ++ A ++ + + CP N P ++ +
Sbjct: 1398 LLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENL 1457
Query: 885 SPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPES 944
+ T T S+ A S+ + Q + I E + VII SL E
Sbjct: 1458 QNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQ-GGLGIAISEEDTLSGVIIKSLT--EH 1514
Query: 945 GSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTL 1004
G T DG +LKVGD+ILAV+ + ++ P + L+K A ++V L
Sbjct: 1515 GVAAT---------DG-------RLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKL 1558
Query: 1005 RIIPQ----EELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSP-------ATP----NS 1049
I + + + S A S EK++ + QS + QS +P +TP +
Sbjct: 1559 TIHAENPDSQAVPSAAGAASGEKKN--SSQSLMVPQSGSPEPESIRNTSRSSTPAIFASD 1616
Query: 1050 PIAQPAPP---QPLQL-QGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGD 1105
P P P +++ +G S V + I + D R G
Sbjct: 1617 PATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQ 1676
Query: 1106 YQQPPPLDYRQPP---LLDYRQHSPDTRQYPL----SDYRQPQDFDYFTVDMEKG-AKGF 1157
+ +D R+ ++ + +P + L + Y++ + D T++++K KG
Sbjct: 1677 ILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGL 1736
Query: 1158 GFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIK 1215
G SI G R ++V + + G A +GR+ GDQI+ +NGE R+ T L+K
Sbjct: 1737 GLSIVGKRN-DTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLK 1793
Score = 85.1 bits (209), Expect = 4e-16
Identities = 150/687 (21%), Positives = 261/687 (37%), Gaps = 210/687 (30%)
Query: 429 LKKSNMGFGFTIIG---GDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYIN-EVCVLGH 484
LK + G GF+++G + + + V+ + A +DG+++ D I+ IN +
Sbjct: 141 LKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTI 200
Query: 485 THADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNY 544
TH + + Q +V LV+ RG LP +V P+
Sbjct: 201 THQQAISILQKAK--DTVQLVIARG-SLP--------QLVSPI----------------- 232
Query: 545 ETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELM 604
+SR+ + I S HS P Q +
Sbjct: 233 ------VSRSPSAASTI------SAHSNPVHWQ------------------------HME 256
Query: 605 TLTIVKGAQGFGF-TIADSPTGQRVKQILDIQGCPG--------LCEGDLIVEINQQNVQ 655
T+ +V G GF I TG VK IL PG LC GD I++I ++
Sbjct: 257 TIELVNDGSGLGFGIIGGKATGVIVKTIL-----PGGVADQHGRLCSGDHILKIGDTDLA 311
Query: 656 NLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQ 715
+S +V +L+ C G+ L+I RG E + +P T+L
Sbjct: 312 GMSSEQVAQVLRQC--GNRVKLMIARGAI--------------EERTAP-TALG------ 348
Query: 716 NLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSS---GP 772
+ SS P ST R+D+S G
Sbjct: 349 -------ITLSSSPTSTP------------------------------ELRVDASTQKGE 371
Query: 773 DYKELDVHLRRMESGFGFRILG--GDEPGQP--ILIGAVIAMGSADRDGRLHPGDELVYV 828
+ + DV L + G G I G GD+ +P I + ++ + + DGR+ GD+++ V
Sbjct: 372 ESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAV 431
Query: 829 DGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRK-------VLCGGEPCPENGRSP--GSV 879
DG + G T++ ++++ H + V LT+ R+ ++ + + SP S+
Sbjct: 432 DGTNLQGFTNQQAVEVLRHTGQT--VLLTLMRRGMKQEAELMSREDVTKDADLSPVNASI 489
Query: 880 STHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENE---------- 929
+ D+ + T + + P+ EG+ S + ++ +K+
Sbjct: 490 IKENYEKDEDFLSSTRNTNILPTEE----EGYPLLSAEIEEIEDAQKQEAALLTKWQRIM 545
Query: 930 GFGF-VIISSLNRPESGSTITVP-------HKIGRIIDGSPADRCAKLKVGDRILAVNGQ 981
G + ++++ +++ S + + H I ++ P KL GD +L VNG
Sbjct: 546 GINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGI 605
Query: 982 SIINMPHADIVKLIKDAGLSVTL----RIIP---QEELNS-------PTSAP-------- 1019
+++ H D+V ++K+ + VT+ R +P Q EL+S T P
Sbjct: 606 TLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFI 665
Query: 1020 -SSEKQSPM-----AQQSPLAQQSPLA 1040
SSE + P+ A QS Q+PLA
Sbjct: 666 GSSETEDPVLAMTDAGQSTEEVQAPLA 692
Score = 70.5 bits (171), Expect = 1e-11
Identities = 119/620 (19%), Positives = 222/620 (35%), Gaps = 145/620 (23%)
Query: 420 LKGTFLSTTLKKSNMGFGFTIIGGDEPDEF-LQVKSVIPDGPAAQDGKMETGDVIVYINE 478
L G L+K + G G ++ G + + + + P+G A +DG+++ D ++ IN
Sbjct: 1344 LTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
Query: 479 VCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMV 538
+ G +H + + + P V ++ R +D N M P P
Sbjct: 1404 QILYGRSHQNASSIIKCAP--SKVKIIFIRN-------KDAVNQMAVCPGNAVEPLPSNS 1454
Query: 539 NGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGA 598
N ET P V + ++ S
Sbjct: 1455 ENLQNKET------------------------------------EPTVTTSDAAVDLSSF 1478
Query: 599 TQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILD--IQGCPG-LCEGDLIVEINQQNVQ 655
+ + L +G G + D+ +G +K + + + G L GD I+ ++ + V
Sbjct: 1479 KNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVV 1538
Query: 656 NLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQ 715
+ + +LK + L IH + ++Q P + +A +
Sbjct: 1539 GYPIEKFISLLKTAKM--TVKLTIHA--------------ENPDSQAVPSAAGAASGEKK 1582
Query: 716 NLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYK 775
N + +S P+P + SR+ + P T +
Sbjct: 1583 NSSQSLMVPQSG-----------SPEPESIRNTSRSSTPAIFASDPATCPIIPGC----- 1626
Query: 776 ELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAM-----GSADRDGRLHPGDELVYVDG 830
E + + + +G G I+GG + L+GA+I G+A +DGRL GD+++ V+G
Sbjct: 1627 ETTIEISKGRTGLGLSIVGGSDT----LLGAIIIHEVYEEGAACKDGRLWAGDQILEVNG 1682
Query: 831 IPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDY 890
I + TH I+++ + +V LT+ R D
Sbjct: 1683 IDLRKATHDEAINVLRQTPQ--RVRLTLYR----------------------------DE 1712
Query: 891 ATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITV 950
A Y T + + +K +G G I+ N ++G ++
Sbjct: 1713 APYKEEEVC-----------------DTLTIELQKKPGKGLGLSIVGKRN--DTGVFVS- 1752
Query: 951 PHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQE 1010
I+ G AD +L GD+IL VNG+ + N + L+K + S++ P
Sbjct: 1753 -----DIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLS 1807
Query: 1011 ELNSPTSAPSSEKQSPMAQQ 1030
++ S SS K++ +A +
Sbjct: 1808 GSSTSESLESSSKKNALASE 1827
Score = 64.7 bits (156), Expect = 6e-10
Identities = 51/208 (24%), Positives = 90/208 (43%), Gaps = 28/208 (13%)
Query: 801 PILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRR 860
PI I + G A + +L GD +V + G G TH ++L+ +A+ + +
Sbjct: 1860 PIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGS------IEM 1913
Query: 861 KVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTN-SNHAAPSSNASPPEGFASHSLQTS 919
+V+ GG+ G H P S ++T ++ + + PP Q
Sbjct: 1914 QVVAGGDVSVVTG--------HQQEPASSSLSFTGLTSSSIFQDDLGPP--------QCK 1957
Query: 920 DVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVN 979
+ + R +G GF I+ P +P + + A +LK GD+I+AVN
Sbjct: 1958 SITLERGP-DGLGFSIVGGYGSPHGD----LPIYVKTVFAKGAASEDGRLKRGDQIIAVN 2012
Query: 980 GQSIINMPHADIVKLIKDAGLSVTLRII 1007
GQS+ + H + V ++K +VTL ++
Sbjct: 2013 GQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 64.3 bits (155), Expect = 8e-10
Identities = 117/499 (23%), Positives = 207/499 (41%), Gaps = 68/499 (13%)
Query: 383 AKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLST---TLKKSNMGFGFT 439
A+ +++ P T LG +P P DAS KG T L K+ G G T
Sbjct: 334 ARGAIEERTAP-TALGITLSSSP--TSTPELRVDASTQKGEESETFDVELTKNVQGLGIT 390
Query: 440 IIG--GDEPDE--FLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQS 495
I G GD+ E + VKS+ DG+++ GD I+ ++ + G T+ V++ +
Sbjct: 391 IAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRH 450
Query: 496 VPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTS 555
GQ+V L L R + + E + V A + ++ + NYE +++S T
Sbjct: 451 T--GQTVLLTLMRR-GMKQEAELMSREDVTKDADLSPVNASII--KENYEKDEDFLSSTR 505
Query: 556 QSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSG----ATQAELMTLTIVKG 611
+ T+ + L S + D ++ + E++ + K
Sbjct: 506 NTNILPTEEEGYPLLSAEIEEIEDA------QKQEAALLTKWQRIMGINYEIVVAHVSKF 559
Query: 612 AQGFGFTIA-DSPTGQRVKQILDIQGCPG----LCEGDLIVEINQQNVQNLSHTEVVDIL 666
++ G I+ ++ G + + +G G L GD ++E+N + +H +VV+IL
Sbjct: 560 SENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNIL 619
Query: 667 KDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRS 726
K+ PI E +++ R +T P S SL I L P +
Sbjct: 620 KELPI--EVTMVCCR-------RTVPPTTQ------SELDSLDLCDI--ELTEKPHVDLG 662
Query: 727 SFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPP-RTSFRMDSSGPDYKELDVHLRRME 785
F S+E DP A+ ++ Q + M +G + EL+ +
Sbjct: 663 EFIGSSETEDP-----------VLAMTDAGQSTEEVQAPLAMWEAGIQHIELE----KGS 707
Query: 786 SGFGFRILGGDEPGQP----ILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYV 841
G GF IL +P P I+I +++ G A++DGRL PGD L++V+ + + +
Sbjct: 708 KGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEA 767
Query: 842 IDLMHHAARNGQVNLTVRR 860
++ + A +G V + V +
Sbjct: 768 VEAL-KGAPSGTVRIGVAK 785
Score = 63.2 bits (152), Expect = 2e-09
Identities = 32/82 (39%), Positives = 50/82 (60%), Gaps = 1/82 (1%)
Query: 1147 TVDMEKGAKGFGFSIRGGREYKMDLYVLR-LAEDGPAIRNGRMRVGDQIIEINGESTRDM 1205
T+++ KG G G SI GG + + ++ + E+G A ++GR+ GDQI+E+NG R
Sbjct: 1629 TIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKA 1688
Query: 1206 THARAIELIKSGGRRVRLLLKR 1227
TH AI +++ +RVRL L R
Sbjct: 1689 THDEAINVLRQTPQRVRLTLYR 1710
Score = 62.4 bits (150), Expect = 3e-09
Identities = 104/482 (21%), Positives = 175/482 (36%), Gaps = 108/482 (22%)
Query: 420 LKGTFLSTTLKKSNMGFGFTIIGG-DEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINE 478
+ G + + K G G +I+GG D + + V +G A +DG++ GD I+ +N
Sbjct: 1623 IPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNG 1682
Query: 479 VCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPP--- 535
+ + TH + + + + P Q V L L R P+ E+ +++ + + ++P
Sbjct: 1683 IDLRKATHDEAINVLRQTP--QRVRLTLYRD-EAPYKEEEVCDTLT--IELQKKPGKGLG 1737
Query: 536 -VMVNGRHNYETYLEYISR-------------------TSQSVPDITDRPPHSLHSMPTD 575
+V R++ ++ I + + V + T +L +
Sbjct: 1738 LSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEG 1797
Query: 576 GQLDGTYPPPVHDDNVSMASSGATQA------ELMTLTIVKG---------AQGFGFTIA 620
T+P + S+ SS A L T+ + KG A G G +
Sbjct: 1798 SLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLG 1857
Query: 621 DSPTGQRVKQILDIQG-CPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLII 679
D P + + L GD IV I + + ++HT+ V++LK+ E ++
Sbjct: 1858 DVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVV- 1916
Query: 680 HRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRK 739
GG S +Q P +S +L F S F D
Sbjct: 1917 -AGGDVSVVT---------GHQQEPASS--------SLSFTGLTSSSIFQDDLG------ 1952
Query: 740 PDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGG---D 796
PP+ GPD G GF I+GG
Sbjct: 1953 --------------------PPQCKSITLERGPD-------------GLGFSIVGGYGSP 1979
Query: 797 EPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNL 856
PI + V A G+A DGRL GD+++ V+G + G TH + ++ G V L
Sbjct: 1980 HGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRT--KGTVTL 2037
Query: 857 TV 858
V
Sbjct: 2038 MV 2039
Score = 55.5 bits (132), Expect = 4e-07
Identities = 29/82 (35%), Positives = 47/82 (57%), Gaps = 3/82 (3%)
Query: 1147 TVDMEKGAKGFGFSIRGGR---EYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTR 1203
++ +E+G G GFSI GG + +YV + G A +GR++ GDQII +NG+S
Sbjct: 1958 SITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLE 2017
Query: 1204 DMTHARAIELIKSGGRRVRLLL 1225
+TH A+ ++K V L++
Sbjct: 2018 GVTHEEAVAILKRTKGTVTLMV 2039
Score = 54.7 bits (130), Expect = 6e-07
Identities = 74/297 (24%), Positives = 118/297 (39%), Gaps = 51/297 (17%)
Query: 757 QQVPPRTSFRMDSSGPDYKE------LDVHLRRMES-GFGFRILGG-DEPGQPILIGAVI 808
+Q P R + YKE L + L++ G G I+G ++ G + + ++
Sbjct: 1698 RQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTG--VFVSDIV 1755
Query: 809 AMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEP 868
G AD DGRL GD+++ V+G V T V L+ KV
Sbjct: 1756 KGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL---------------KV------ 1794
Query: 869 CPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKEN 928
S GS+S+ + P S +T + S ++ NA AS V + +
Sbjct: 1795 ------SEGSLSSF-TFPLSGSST-SESLESSSKKNA-----LASEIQGLRTVEMKKGPT 1841
Query: 929 EGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPH 988
+ G I + P VP I + A + KL+VGDRI+ + G S M H
Sbjct: 1842 DSLGISIAGGVGSPLGD----VPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTH 1897
Query: 989 ADIVKLIKDAGLSVTLRIIPQEELNSPT---SAPSSEKQSPMAQQSPLAQQSPLAQP 1042
V L+K+A S+ ++++ +++ T P+S S S Q L P
Sbjct: 1898 TQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPP 1954
Score = 52.4 bits (124), Expect = 3e-06
Identities = 32/97 (32%), Positives = 58/97 (59%), Gaps = 6/97 (6%)
Query: 1156 GFGFSIRGGREY---KMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGES-TRDMTHARAI 1211
G GFS+ G R ++ ++V + E A R+GR++ DQI+ ING++ + +TH +AI
Sbjct: 147 GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
Query: 1212 ELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAA 1248
+++ V+L++ RG+ +P+ P SP+AA+
Sbjct: 207 SILQKAKDTVQLVIARGS--LPQLVSPIVSRSPSAAS 241
Score = 50.4 bits (119), Expect = 1e-05
Identities = 38/122 (31%), Positives = 60/122 (49%), Gaps = 12/122 (9%)
Query: 1147 TVDMEKG-AKGFGFSIRGGREYKMD---LYVLRLAEDGPAIRNGRMRVGDQIIEINGEST 1202
TV+M+KG G SI GG + +++ + G A + ++RVGD+I+ I G ST
Sbjct: 1833 TVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTST 1892
Query: 1203 RDMTHARAIELIKSGGRRVRLLLKRGTGQVP----EYDEPAPWSSPAAAAPGLPEVGVSL 1258
MTH +A+ L+K+ + + + G G V EPA S + + GL +
Sbjct: 1893 EGMTHTQAVNLLKNASGSIEMQVVAG-GDVSVVTGHQQEPA---SSSLSFTGLTSSSIFQ 1948
Query: 1259 DD 1260
DD
Sbjct: 1949 DD 1950
Score = 50.1 bits (118), Expect = 2e-05
Identities = 28/99 (28%), Positives = 59/99 (59%), Gaps = 5/99 (5%)
Query: 1141 QDFDYFTVDMEKGAKGFGFSIRGG-REYKMD---LYVLRLAEDGPAIRNGRMRVGDQIIE 1196
++ + F V++ K +G G +I G + K++ ++V + + +GR+++GDQII
Sbjct: 371 EESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIA 430
Query: 1197 INGESTRDMTHARAIELIKSGGRRVRL-LLKRGTGQVPE 1234
++G + + T+ +A+E+++ G+ V L L++RG Q E
Sbjct: 431 VDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAE 469
Score = 44.7 bits (104), Expect = 7e-04
Identities = 29/111 (26%), Positives = 54/111 (48%), Gaps = 5/111 (4%)
Query: 1147 TVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMT 1206
T+++ G GF I GG+ + V + G A ++GR+ GD I++I M+
Sbjct: 257 TIELVNDGSGLGFGIIGGKA--TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMS 314
Query: 1207 HARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAP-GLPEVGV 1256
+ ++++ G RV+L++ RG + E P +++P PE+ V
Sbjct: 315 SEQVAQVLRQCGNRVKLMIARGA--IEERTAPTALGITLSSSPTSTPELRV 363
Score = 38.5 bits (88), Expect = 0.048
Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 16/116 (13%)
Query: 930 GFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSI-INMPH 988
GF V + S NR E G + I +GS A R +LK D+ILA+NGQ++ + H
Sbjct: 149 GFSVVGLRSENRGELGIFVQ------EIQEGSVAHRDGRLKETDQILAINGQALDQTITH 202
Query: 989 ADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSP 1044
+ +++ A +V L +I + L + SP+ +SP A + A +P
Sbjct: 203 QQAISILQKAKDTVQL-VIARGSL--------PQLVSPIVSRSPSAASTISAHSNP 249
Score = 37.7 bits (86), Expect = 0.081
Identities = 27/97 (27%), Positives = 51/97 (52%), Gaps = 6/97 (6%)
Query: 10 HWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEV 69
HW E++ N LGF + GG G + + PG VA + G +L S + +L++
Sbjct: 251 HWQHM--ETIELVNDGSGLGFGIIGGKATGVI--VKTILPGGVADQHG-RLCSGDHILKI 305
Query: 70 NETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDK 106
+T +AG++ V V++ C + ++L + +G I ++
Sbjct: 306 GDTDLAGMSSEQVAQVLRQCGNRVKL-MIARGAIEER 341
Score = 37.0 bits (84), Expect = 0.14
Identities = 20/72 (27%), Positives = 40/72 (55%), Gaps = 4/72 (5%)
Query: 1148 VDMEKGAKGFGFSIRGGRE----YKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTR 1203
+++EKG+KG GFSI ++ + + L G A ++GR+ GD+++ +N +
Sbjct: 701 IELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLE 760
Query: 1204 DMTHARAIELIK 1215
+ + A+E +K
Sbjct: 761 NSSLEEAVEALK 772
Score = 37.0 bits (84), Expect = 0.14
Identities = 33/127 (25%), Positives = 55/127 (43%), Gaps = 10/127 (7%)
Query: 1148 VDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTH 1207
+++ K G G +I + + + L E G A +GR++VGDQI+ ++ E
Sbjct: 1484 LELPKDQGGLGIAI-SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPI 1542
Query: 1208 ARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSP 1267
+ I L+K+ V+L + + P + P+AA E S + P S
Sbjct: 1543 EKFISLLKTAKMTVKLTI--------HAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSG 1594
Query: 1268 SHPAPPS 1274
S P P S
Sbjct: 1595 S-PEPES 1600
Score = 32.7 bits (73), Expect = 2.6
Identities = 63/267 (23%), Positives = 95/267 (35%), Gaps = 78/267 (29%)
Query: 417 ASQLKGTFLSTTLKKSNMGFGFTIIGG-DEP--DEFLQVKSVIPDGPAAQDGKMETGDVI 473
AS+++G K G +I GG P D + + + P G AAQ K+ GD I
Sbjct: 1825 ASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRI 1884
Query: 474 VYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPF---DPEDPANSMVPPLAIM 530
V I G TH V L ++ S+ + + G + ++PA+S
Sbjct: 1885 VTICGTSTEGMTHTQAVNLLKNA--SGSIEMQVVAGGDVSVVTGHQQEPASSS------- 1935
Query: 531 ERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDN 590
L + TS S+ PP
Sbjct: 1936 -----------------LSFTGLTSSSIFQDDLGPP------------------------ 1954
Query: 591 VSMASSGATQAELMTLTIVKGAQGFGFTIA---DSPTGQ---RVKQILDIQGCPG----L 640
Q + +TL +G G GF+I SP G VK + +G L
Sbjct: 1955 ---------QCKSITLE--RGPDGLGFSIVGGYGSPHGDLPIYVKTVF-AKGAASEDGRL 2002
Query: 641 CEGDLIVEINQQNVQNLSHTEVVDILK 667
GD I+ +N Q+++ ++H E V ILK
Sbjct: 2003 KRGDQIIAVNGQSLEGVTHEEAVAILK 2029
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 103 bits (257), Expect = 1e-21
Identities = 126/539 (23%), Positives = 220/539 (40%), Gaps = 94/539 (17%)
Query: 762 RTSFRMDSSGPDYKE--LDVHLRRMESGFGFRILGGDEPGQP---ILIGAVIAMGSADRD 816
+ +F+ SS P +V L + ++ G + GG I + AVI G+A+ D
Sbjct: 1159 KMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESD 1218
Query: 817 GRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSP 876
GR+H GD ++ V+G+ + G TH+ ++ + + + + L E G+SP
Sbjct: 1219 GRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL--------------EKGQSP 1264
Query: 877 GSVSTHHSSPR---SDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGF 933
S +P+ SD + F + T +V + K + G GF
Sbjct: 1265 TSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEE-NTFEVKLF-KNSSGLGF 1322
Query: 934 VIISSLNR-PESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIV 992
N PE + V ++ ++ G PA K+ VGD IL VNG S+ + +++
Sbjct: 1323 SFSREDNLIPEQINASIV--RVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVI 1380
Query: 993 KLIKDAGLSVTL-------RIIPQEE------LNSP----------TSAPSSEKQSPMAQ 1029
++ V L ++P+ + L SP +S PS +QS +
Sbjct: 1381 SALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSD 1440
Query: 1030 QSPLAQQSPLAQPSP--------------------------ATPNSPIAQPAPPQPLQLQ 1063
++ ++ +S SP +T +S + Q Q Q
Sbjct: 1441 ENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQ 1500
Query: 1064 GHENSYRSEVKARQDV----KPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPL 1119
H + +S+ + + +P F D PL PG Y QP +
Sbjct: 1501 SHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSY-QPQSESASSSSM 1559
Query: 1120 LDYRQH--SPDTRQ---YPLSD--YRQPQDFDY---FTVDMEKGAKG-FGFSIRGGREYK 1168
Y H S TRQ PL + +DF+ + + K KG GF++ G + +
Sbjct: 1560 DKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQ-R 1618
Query: 1169 MDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKR 1227
+ YV + +D PA +GR++ GD++I++N +MTH A+ L+++ + VRL++ R
Sbjct: 1619 IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1676
Score = 60.1 bits (144), Expect = 2e-08
Identities = 34/104 (32%), Positives = 55/104 (52%), Gaps = 5/104 (4%)
Query: 1140 PQDFDYFTVDMEKGAKGFGFSIRGGREYKM---DLYVLRLAEDGPAIRNGRMRVGDQIIE 1196
P+ D F V++ K G S+ GG + +YV + G A +GR+ GD+++
Sbjct: 1170 PKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLA 1229
Query: 1197 INGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAP 1240
+NG S TH +A+E +++ G+ V LLL++ GQ P E P
Sbjct: 1230 VNGVSLEGATHKQAVETLRNTGQVVHLLLEK--GQSPTSKEHVP 1271
Score = 57.0 bits (136), Expect = 1e-07
Identities = 103/446 (23%), Positives = 172/446 (38%), Gaps = 96/446 (21%)
Query: 429 LKKSNMGFGFTIIGGDE--PDEF----LQVKSVIPDGPAAQDGKMETGDVIVYINEVCVL 482
L K++ G GF+ D P++ ++VK + P PAA+ GK++ GDVI+ +N +
Sbjct: 1313 LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLK 1372
Query: 483 GHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRH 542
G + +V+ + V L+LCR P D A ++ PL + P V+ N
Sbjct: 1373 GLSQQEVISALRGT--APEVFLLLCRPPPGVLPEIDTA--LLTPL---QSPAQVLPNSSK 1425
Query: 543 NYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAE 602
+ TS +++D+ S P D+ S SSG+ + +
Sbjct: 1426 DSSQPSCVEQSTSSDENEMSDKSKKQCKS-------------PSRRDSYS-DSSGSGEDD 1471
Query: 603 LMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEV 662
L+T I++S + Q L + Q SH E
Sbjct: 1472 LVTAPA---------NISNSTWSSALHQTL-----------------SNMVSQAQSHHEA 1505
Query: 663 VDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPA 722
P E ++ F+ P K P P+ S P+ P PP
Sbjct: 1506 -------PKSQEDTICTM---FYYPQKIPN----------KPEFEDSNPS-----PLPPD 1540
Query: 723 LHRS-SFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYK---ELD 778
+ S+ +E+ D Y ++ S +RQ+ +++ D++ EL
Sbjct: 1541 MAPGQSYQPQSESASSSSMDKYHIHHISEP---TRQENWTPLKNDLENHLEDFELEVELL 1597
Query: 779 VHLRRMESG-FGFRILGGDEPGQPILIGAVI---AMGSADRDGRLHPGDELVYVDGIPVA 834
+ L + E G GF + G++ IG + A DGRL PGD L+ V+ V
Sbjct: 1598 ITLIKSEKGSLGFTVTKGNQR-----IGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVT 1652
Query: 835 GKTHRYVIDLMHHAARNGQVNLTVRR 860
TH ++L+ A++ V L + R
Sbjct: 1653 NMTHTDAVNLLRAASKT--VRLVIGR 1676
Score = 51.6 bits (122), Expect = 5e-06
Identities = 29/83 (34%), Positives = 50/83 (60%), Gaps = 4/83 (4%)
Query: 770 SGPDYKELDVHLRR-MESGFGFRILGGDEPGQ---PILIGAVIAMGSADRDGRLHPGDEL 825
S P+ + V+L++ + G GF+I+GG++ G+ I I +V G AD DG L PGD L
Sbjct: 894 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 953
Query: 826 VYVDGIPVAGKTHRYVIDLMHHA 848
+ V+ + + G +H I+++ +A
Sbjct: 954 ISVNSVSLEGVSHHAAIEILQNA 976
Score = 50.4 bits (119), Expect = 1e-05
Identities = 28/80 (35%), Positives = 46/80 (57%), Gaps = 5/80 (6%)
Query: 430 KKSNMGFGFTIIGGDEP---DEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTH 486
K + G GF IIGG++ D + + SV P GPA DG ++ GD ++ +N V + G +H
Sbjct: 907 KDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 966
Query: 487 ADVVKLFQSVPIGQSVNLVL 506
+++ Q+ P + V LV+
Sbjct: 967 HAAIEILQNAP--EDVTLVI 984
Score = 48.5 bits (114), Expect = 5e-05
Identities = 28/84 (33%), Positives = 52/84 (61%), Gaps = 4/84 (4%)
Query: 1148 VDMEKGAK-GFGFSIRGGREY-KMDL--YVLRLAEDGPAIRNGRMRVGDQIIEINGESTR 1203
V+++K AK G GF I GG + ++DL ++ +A GPA +G ++ GD++I +N S
Sbjct: 903 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 962
Query: 1204 DMTHARAIELIKSGGRRVRLLLKR 1227
++H AIE++++ V L++ +
Sbjct: 963 GVSHHAAIEILQNAPEDVTLVISQ 986
Score = 48.5 bits (114), Expect = 5e-05
Identities = 81/359 (22%), Positives = 142/359 (39%), Gaps = 62/359 (17%)
Query: 422 GTFLSTTLKKSNMGFGFTIIGGDEPDEF---LQVKSVIPDGPAAQDGKMETGDVIVYINE 478
G L K++ G ++ GG + VK+VIP G A DG++ GD ++ +N
Sbjct: 1173 GDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 1232
Query: 479 VCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMV 538
V + G TH V+ ++ GQ V+L+L +G + P + P+ P +
Sbjct: 1233 VSLEGATHKQAVETLRNT--GQVVHLLLEKG-------QSPTSKEHVPVT-----PQCTL 1278
Query: 539 NGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGA 598
+ ++ E + +T+Q V D +S T+ + T+ + ++ + S +
Sbjct: 1279 SDQNAQGQGPEKVKKTTQ-VKD---------YSFVTE---ENTFEVKLFKNSSGLGFSFS 1325
Query: 599 TQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLS 658
+ L+ I P + K +D+ GD+I+++N +++ LS
Sbjct: 1326 REDNLIPEQINASIVRVKKLFPGQPAAESGK--IDV--------GDVILKVNGASLKGLS 1375
Query: 659 HTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLP 718
EV+ L+ E L++ R P P +D T+L P
Sbjct: 1376 QQEVISALRG--TAPEVFLLLCR-----PPPGVLPEID---------TALLTPLQSPAQV 1419
Query: 719 FPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKEL 777
P + SS P E D E+ +KS+ +S P R DSSG +L
Sbjct: 1420 LPNSSKDSSQPSCVE--QSTSSDENEMSDKSKKQCKS----PSRRDSYSDSSGSGEDDL 1472
Score = 47.4 bits (111), Expect = 1e-04
Identities = 45/157 (28%), Positives = 67/157 (42%), Gaps = 32/157 (20%)
Query: 1123 RQHSPDTRQYPLSDYR-------------QPQDFDY------FTVDMEKGAKGFGFSIRG 1163
++H P T Q LSD Q +D+ + F V + K + G GFS
Sbjct: 1267 KEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSF-- 1324
Query: 1164 GREYKMD--------LYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIK 1215
RE + + V +L PA +G++ VGD I+++NG S + ++ I ++
Sbjct: 1325 SREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1384
Query: 1216 SGGRRVRLLLKR-GTGQVPEYDEP--APWSSPAAAAP 1249
V LLL R G +PE D P SPA P
Sbjct: 1385 GTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLP 1421
Score = 47.4 bits (111), Expect = 1e-04
Identities = 33/101 (32%), Positives = 51/101 (50%), Gaps = 4/101 (3%)
Query: 419 QLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINE 478
+L+ L T +K GFT+ G++ V VI D PA DG+++ GD ++ +N+
Sbjct: 1591 ELEVELLITLIKSEKGSLGFTVTKGNQRIG-CYVHDVIQD-PAKSDGRLKPGDRLIKVND 1648
Query: 479 VCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDP 519
V TH D V L ++ ++V LV+ R LP P P
Sbjct: 1649 TDVTNMTHTDAVNLLRAA--SKTVRLVIGRVLELPRIPMLP 1687
Score = 43.1 bits (100), Expect = 0.002
Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 5/91 (5%)
Query: 930 GFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHA 989
G GF II E + + I + G PAD LK GDR+++VN S+ + H
Sbjct: 912 GLGFQIIGG----EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHH 967
Query: 990 DIVKLIKDAGLSVTLRII-PQEELNSPTSAP 1019
++++++A VTL I P+E+++ S P
Sbjct: 968 AAIEILQNAPEDVTLVISQPKEKISKVPSTP 998
Score = 32.3 bits (72), Expect = 3.4
Identities = 20/63 (31%), Positives = 32/63 (50%), Gaps = 1/63 (1%)
Query: 428 TLKKSNMGFGFTIIGG-DEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTH 486
TL + GF++ GG D + + + + P AA +G ++ DVI Y+N V G T
Sbjct: 1694 TLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTL 1753
Query: 487 ADV 489
+V
Sbjct: 1754 EEV 1756
Score = 31.2 bits (69), Expect = 7.6
Identities = 14/47 (29%), Positives = 29/47 (61%), Gaps = 4/47 (8%)
Query: 633 DIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLII 679
D+ GC L GD ++ +N +++ +SH ++IL++ P + +L+I
Sbjct: 942 DLDGC--LKPGDRLISVNSVSLEGVSHHAAIEILQNAP--EDVTLVI 984
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 103 bits (257), Expect = 1e-21
Identities = 126/539 (23%), Positives = 220/539 (40%), Gaps = 94/539 (17%)
Query: 762 RTSFRMDSSGPDYKE--LDVHLRRMESGFGFRILGGDEPGQP---ILIGAVIAMGSADRD 816
+ +F+ SS P +V L + ++ G + GG I + AVI G+A+ D
Sbjct: 1350 KMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESD 1409
Query: 817 GRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSP 876
GR+H GD ++ V+G+ + G TH+ ++ + + + + L E G+SP
Sbjct: 1410 GRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL--------------EKGQSP 1455
Query: 877 GSVSTHHSSPR---SDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGF 933
S +P+ SD + F + T +V + K + G GF
Sbjct: 1456 TSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEE-NTFEVKLF-KNSSGLGF 1513
Query: 934 VIISSLNR-PESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIV 992
N PE + V ++ ++ G PA K+ VGD IL VNG S+ + +++
Sbjct: 1514 SFSREDNLIPEQINASIV--RVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVI 1571
Query: 993 KLIKDAGLSVTL-------RIIPQEE------LNSP----------TSAPSSEKQSPMAQ 1029
++ V L ++P+ + L SP +S PS +QS +
Sbjct: 1572 SALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSD 1631
Query: 1030 QSPLAQQSPLAQPSP--------------------------ATPNSPIAQPAPPQPLQLQ 1063
++ ++ +S SP +T +S + Q Q Q
Sbjct: 1632 ENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQ 1691
Query: 1064 GHENSYRSEVKARQDV----KPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPL 1119
H + +S+ + + +P F D PL PG Y QP +
Sbjct: 1692 SHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSY-QPQSESASSSSM 1750
Query: 1120 LDYRQH--SPDTRQ---YPLSD--YRQPQDFDY---FTVDMEKGAKG-FGFSIRGGREYK 1168
Y H S TRQ PL + +DF+ + + K KG GF++ G + +
Sbjct: 1751 DKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQ-R 1809
Query: 1169 MDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKR 1227
+ YV + +D PA +GR++ GD++I++N +MTH A+ L+++ + VRL++ R
Sbjct: 1810 IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1867
Score = 60.1 bits (144), Expect = 2e-08
Identities = 34/104 (32%), Positives = 55/104 (52%), Gaps = 5/104 (4%)
Query: 1140 PQDFDYFTVDMEKGAKGFGFSIRGGREYKM---DLYVLRLAEDGPAIRNGRMRVGDQIIE 1196
P+ D F V++ K G S+ GG + +YV + G A +GR+ GD+++
Sbjct: 1361 PKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLA 1420
Query: 1197 INGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAP 1240
+NG S TH +A+E +++ G+ V LLL++ GQ P E P
Sbjct: 1421 VNGVSLEGATHKQAVETLRNTGQVVHLLLEK--GQSPTSKEHVP 1462
Score = 57.0 bits (136), Expect = 1e-07
Identities = 103/446 (23%), Positives = 172/446 (38%), Gaps = 96/446 (21%)
Query: 429 LKKSNMGFGFTIIGGDE--PDEF----LQVKSVIPDGPAAQDGKMETGDVIVYINEVCVL 482
L K++ G GF+ D P++ ++VK + P PAA+ GK++ GDVI+ +N +
Sbjct: 1504 LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLK 1563
Query: 483 GHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRH 542
G + +V+ + V L+LCR P D A ++ PL + P V+ N
Sbjct: 1564 GLSQQEVISALRGT--APEVFLLLCRPPPGVLPEIDTA--LLTPL---QSPAQVLPNSSK 1616
Query: 543 NYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAE 602
+ TS +++D+ S P D+ S SSG+ + +
Sbjct: 1617 DSSQPSCVEQSTSSDENEMSDKSKKQCKS-------------PSRRDSYS-DSSGSGEDD 1662
Query: 603 LMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEV 662
L+T I++S + Q L + Q SH E
Sbjct: 1663 LVTAPA---------NISNSTWSSALHQTL-----------------SNMVSQAQSHHEA 1696
Query: 663 VDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPA 722
P E ++ F+ P K P P+ S P+ P PP
Sbjct: 1697 -------PKSQEDTICTM---FYYPQKIPN----------KPEFEDSNPS-----PLPPD 1731
Query: 723 LHRS-SFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYK---ELD 778
+ S+ +E+ D Y ++ S +RQ+ +++ D++ EL
Sbjct: 1732 MAPGQSYQPQSESASSSSMDKYHIHHISEP---TRQENWTPLKNDLENHLEDFELEVELL 1788
Query: 779 VHLRRMESG-FGFRILGGDEPGQPILIGAVI---AMGSADRDGRLHPGDELVYVDGIPVA 834
+ L + E G GF + G++ IG + A DGRL PGD L+ V+ V
Sbjct: 1789 ITLIKSEKGSLGFTVTKGNQR-----IGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVT 1843
Query: 835 GKTHRYVIDLMHHAARNGQVNLTVRR 860
TH ++L+ A++ V L + R
Sbjct: 1844 NMTHTDAVNLLRAASKT--VRLVIGR 1867
Score = 52.4 bits (124), Expect = 3e-06
Identities = 51/194 (26%), Positives = 86/194 (44%), Gaps = 18/194 (9%)
Query: 673 SETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTS------LSAPAIPQNLPFPPALHRS 726
S+ SL HR + P + + S Q S L+ N +L+RS
Sbjct: 974 SQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRS 1033
Query: 727 SFPDSTEAFDPRKPDPYELYEKSRAIYES---RQQVPPRTSFRMDS-----SGPDYKELD 778
E+ DP + Y ++ S QVP + + + S P+ +
Sbjct: 1034 PERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITL 1093
Query: 779 VHLRR-MESGFGFRILGGDEPGQ---PILIGAVIAMGSADRDGRLHPGDELVYVDGIPVA 834
V+L++ + G GF+I+GG++ G+ I I +V G AD DG L PGD L+ V+ + +
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153
Query: 835 GKTHRYVIDLMHHA 848
G +H I+++ +A
Sbjct: 1154 GVSHHAAIEILQNA 1167
Score = 50.4 bits (119), Expect = 1e-05
Identities = 28/80 (35%), Positives = 46/80 (57%), Gaps = 5/80 (6%)
Query: 430 KKSNMGFGFTIIGGDEP---DEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTH 486
K + G GF IIGG++ D + + SV P GPA DG ++ GD ++ +N V + G +H
Sbjct: 1098 KDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 1157
Query: 487 ADVVKLFQSVPIGQSVNLVL 506
+++ Q+ P + V LV+
Sbjct: 1158 HAAIEILQNAP--EDVTLVI 1175
Score = 48.5 bits (114), Expect = 5e-05
Identities = 28/84 (33%), Positives = 52/84 (61%), Gaps = 4/84 (4%)
Query: 1148 VDMEKGAK-GFGFSIRGGREY-KMDL--YVLRLAEDGPAIRNGRMRVGDQIIEINGESTR 1203
V+++K AK G GF I GG + ++DL ++ +A GPA +G ++ GD++I +N S
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153
Query: 1204 DMTHARAIELIKSGGRRVRLLLKR 1227
++H AIE++++ V L++ +
Sbjct: 1154 GVSHHAAIEILQNAPEDVTLVISQ 1177
Score = 48.5 bits (114), Expect = 5e-05
Identities = 81/359 (22%), Positives = 142/359 (39%), Gaps = 62/359 (17%)
Query: 422 GTFLSTTLKKSNMGFGFTIIGGDEPDEF---LQVKSVIPDGPAAQDGKMETGDVIVYINE 478
G L K++ G ++ GG + VK+VIP G A DG++ GD ++ +N
Sbjct: 1364 GDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 1423
Query: 479 VCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMV 538
V + G TH V+ ++ GQ V+L+L +G + P + P+ P +
Sbjct: 1424 VSLEGATHKQAVETLRNT--GQVVHLLLEKG-------QSPTSKEHVPVT-----PQCTL 1469
Query: 539 NGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGA 598
+ ++ E + +T+Q V D +S T+ + T+ + ++ + S +
Sbjct: 1470 SDQNAQGQGPEKVKKTTQ-VKD---------YSFVTE---ENTFEVKLFKNSSGLGFSFS 1516
Query: 599 TQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLS 658
+ L+ I P + K +D+ GD+I+++N +++ LS
Sbjct: 1517 REDNLIPEQINASIVRVKKLFPGQPAAESGK--IDV--------GDVILKVNGASLKGLS 1566
Query: 659 HTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLP 718
EV+ L+ E L++ R P P +D T+L P
Sbjct: 1567 QQEVISALRG--TAPEVFLLLCR-----PPPGVLPEID---------TALLTPLQSPAQV 1610
Query: 719 FPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKEL 777
P + SS P E D E+ +KS+ +S P R DSSG +L
Sbjct: 1611 LPNSSKDSSQPSCVE--QSTSSDENEMSDKSKKQCKS----PSRRDSYSDSSGSGEDDL 1663
Score = 47.4 bits (111), Expect = 1e-04
Identities = 45/157 (28%), Positives = 67/157 (42%), Gaps = 32/157 (20%)
Query: 1123 RQHSPDTRQYPLSDYR-------------QPQDFDY------FTVDMEKGAKGFGFSIRG 1163
++H P T Q LSD Q +D+ + F V + K + G GFS
Sbjct: 1458 KEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSF-- 1515
Query: 1164 GREYKMD--------LYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIK 1215
RE + + V +L PA +G++ VGD I+++NG S + ++ I ++
Sbjct: 1516 SREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1575
Query: 1216 SGGRRVRLLLKR-GTGQVPEYDEP--APWSSPAAAAP 1249
V LLL R G +PE D P SPA P
Sbjct: 1576 GTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLP 1612
Score = 47.4 bits (111), Expect = 1e-04
Identities = 33/101 (32%), Positives = 51/101 (50%), Gaps = 4/101 (3%)
Query: 419 QLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINE 478
+L+ L T +K GFT+ G++ V VI D PA DG+++ GD ++ +N+
Sbjct: 1782 ELEVELLITLIKSEKGSLGFTVTKGNQRIG-CYVHDVIQD-PAKSDGRLKPGDRLIKVND 1839
Query: 479 VCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDP 519
V TH D V L ++ ++V LV+ R LP P P
Sbjct: 1840 TDVTNMTHTDAVNLLRAA--SKTVRLVIGRVLELPRIPMLP 1878
Score = 43.1 bits (100), Expect = 0.002
Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 5/91 (5%)
Query: 930 GFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHA 989
G GF II E + + I + G PAD LK GDR+++VN S+ + H
Sbjct: 1103 GLGFQIIGG----EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHH 1158
Query: 990 DIVKLIKDAGLSVTLRII-PQEELNSPTSAP 1019
++++++A VTL I P+E+++ S P
Sbjct: 1159 AAIEILQNAPEDVTLVISQPKEKISKVPSTP 1189
Score = 32.3 bits (72), Expect = 3.4
Identities = 20/63 (31%), Positives = 32/63 (50%), Gaps = 1/63 (1%)
Query: 428 TLKKSNMGFGFTIIGG-DEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTH 486
TL + GF++ GG D + + + + P AA +G ++ DVI Y+N V G T
Sbjct: 1885 TLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTL 1944
Query: 487 ADV 489
+V
Sbjct: 1945 EEV 1947
Score = 31.2 bits (69), Expect = 7.6
Identities = 14/47 (29%), Positives = 29/47 (61%), Gaps = 4/47 (8%)
Query: 633 DIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLII 679
D+ GC L GD ++ +N +++ +SH ++IL++ P + +L+I
Sbjct: 1133 DLDGC--LKPGDRLISVNSVSLEGVSHHAAIEILQNAP--EDVTLVI 1175
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 103 bits (257), Expect = 1e-21
Identities = 126/539 (23%), Positives = 220/539 (40%), Gaps = 94/539 (17%)
Query: 762 RTSFRMDSSGPDYKE--LDVHLRRMESGFGFRILGGDEPGQP---ILIGAVIAMGSADRD 816
+ +F+ SS P +V L + ++ G + GG I + AVI G+A+ D
Sbjct: 1331 KMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESD 1390
Query: 817 GRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSP 876
GR+H GD ++ V+G+ + G TH+ ++ + + + + L E G+SP
Sbjct: 1391 GRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL--------------EKGQSP 1436
Query: 877 GSVSTHHSSPR---SDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGF 933
S +P+ SD + F + T +V + K + G GF
Sbjct: 1437 TSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEE-NTFEVKLF-KNSSGLGF 1494
Query: 934 VIISSLNR-PESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIV 992
N PE + V ++ ++ G PA K+ VGD IL VNG S+ + +++
Sbjct: 1495 SFSREDNLIPEQINASIV--RVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVI 1552
Query: 993 KLIKDAGLSVTL-------RIIPQEE------LNSP----------TSAPSSEKQSPMAQ 1029
++ V L ++P+ + L SP +S PS +QS +
Sbjct: 1553 SALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSD 1612
Query: 1030 QSPLAQQSPLAQPSP--------------------------ATPNSPIAQPAPPQPLQLQ 1063
++ ++ +S SP +T +S + Q Q Q
Sbjct: 1613 ENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQ 1672
Query: 1064 GHENSYRSEVKARQDV----KPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPL 1119
H + +S+ + + +P F D PL PG Y QP +
Sbjct: 1673 SHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSY-QPQSESASSSSM 1731
Query: 1120 LDYRQH--SPDTRQ---YPLSD--YRQPQDFDY---FTVDMEKGAKG-FGFSIRGGREYK 1168
Y H S TRQ PL + +DF+ + + K KG GF++ G + +
Sbjct: 1732 DKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQ-R 1790
Query: 1169 MDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKR 1227
+ YV + +D PA +GR++ GD++I++N +MTH A+ L+++ + VRL++ R
Sbjct: 1791 IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1848
Score = 60.1 bits (144), Expect = 2e-08
Identities = 34/104 (32%), Positives = 55/104 (52%), Gaps = 5/104 (4%)
Query: 1140 PQDFDYFTVDMEKGAKGFGFSIRGGREYKM---DLYVLRLAEDGPAIRNGRMRVGDQIIE 1196
P+ D F V++ K G S+ GG + +YV + G A +GR+ GD+++
Sbjct: 1342 PKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLA 1401
Query: 1197 INGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAP 1240
+NG S TH +A+E +++ G+ V LLL++ GQ P E P
Sbjct: 1402 VNGVSLEGATHKQAVETLRNTGQVVHLLLEK--GQSPTSKEHVP 1443
Score = 57.0 bits (136), Expect = 1e-07
Identities = 103/446 (23%), Positives = 172/446 (38%), Gaps = 96/446 (21%)
Query: 429 LKKSNMGFGFTIIGGDE--PDEF----LQVKSVIPDGPAAQDGKMETGDVIVYINEVCVL 482
L K++ G GF+ D P++ ++VK + P PAA+ GK++ GDVI+ +N +
Sbjct: 1485 LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLK 1544
Query: 483 GHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRH 542
G + +V+ + V L+LCR P D A ++ PL + P V+ N
Sbjct: 1545 GLSQQEVISALRGT--APEVFLLLCRPPPGVLPEIDTA--LLTPL---QSPAQVLPNSSK 1597
Query: 543 NYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAE 602
+ TS +++D+ S P D+ S SSG+ + +
Sbjct: 1598 DSSQPSCVEQSTSSDENEMSDKSKKQCKS-------------PSRRDSYS-DSSGSGEDD 1643
Query: 603 LMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEV 662
L+T I++S + Q L + Q SH E
Sbjct: 1644 LVTAPA---------NISNSTWSSALHQTL-----------------SNMVSQAQSHHEA 1677
Query: 663 VDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPA 722
P E ++ F+ P K P P+ S P+ P PP
Sbjct: 1678 -------PKSQEDTICTM---FYYPQKIPN----------KPEFEDSNPS-----PLPPD 1712
Query: 723 LHRS-SFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYK---ELD 778
+ S+ +E+ D Y ++ S +RQ+ +++ D++ EL
Sbjct: 1713 MAPGQSYQPQSESASSSSMDKYHIHHISEP---TRQENWTPLKNDLENHLEDFELEVELL 1769
Query: 779 VHLRRMESG-FGFRILGGDEPGQPILIGAVI---AMGSADRDGRLHPGDELVYVDGIPVA 834
+ L + E G GF + G++ IG + A DGRL PGD L+ V+ V
Sbjct: 1770 ITLIKSEKGSLGFTVTKGNQR-----IGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVT 1824
Query: 835 GKTHRYVIDLMHHAARNGQVNLTVRR 860
TH ++L+ A++ V L + R
Sbjct: 1825 NMTHTDAVNLLRAASKT--VRLVIGR 1848
Score = 51.6 bits (122), Expect = 5e-06
Identities = 29/83 (34%), Positives = 50/83 (60%), Gaps = 4/83 (4%)
Query: 770 SGPDYKELDVHLRR-MESGFGFRILGGDEPGQ---PILIGAVIAMGSADRDGRLHPGDEL 825
S P+ + V+L++ + G GF+I+GG++ G+ I I +V G AD DG L PGD L
Sbjct: 1066 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 1125
Query: 826 VYVDGIPVAGKTHRYVIDLMHHA 848
+ V+ + + G +H I+++ +A
Sbjct: 1126 ISVNSVSLEGVSHHAAIEILQNA 1148
Score = 50.4 bits (119), Expect = 1e-05
Identities = 28/80 (35%), Positives = 46/80 (57%), Gaps = 5/80 (6%)
Query: 430 KKSNMGFGFTIIGGDEP---DEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTH 486
K + G GF IIGG++ D + + SV P GPA DG ++ GD ++ +N V + G +H
Sbjct: 1079 KDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 1138
Query: 487 ADVVKLFQSVPIGQSVNLVL 506
+++ Q+ P + V LV+
Sbjct: 1139 HAAIEILQNAP--EDVTLVI 1156
Score = 48.5 bits (114), Expect = 5e-05
Identities = 28/84 (33%), Positives = 52/84 (61%), Gaps = 4/84 (4%)
Query: 1148 VDMEKGAK-GFGFSIRGGREY-KMDL--YVLRLAEDGPAIRNGRMRVGDQIIEINGESTR 1203
V+++K AK G GF I GG + ++DL ++ +A GPA +G ++ GD++I +N S
Sbjct: 1075 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1134
Query: 1204 DMTHARAIELIKSGGRRVRLLLKR 1227
++H AIE++++ V L++ +
Sbjct: 1135 GVSHHAAIEILQNAPEDVTLVISQ 1158
Score = 48.5 bits (114), Expect = 5e-05
Identities = 81/359 (22%), Positives = 142/359 (39%), Gaps = 62/359 (17%)
Query: 422 GTFLSTTLKKSNMGFGFTIIGGDEPDEF---LQVKSVIPDGPAAQDGKMETGDVIVYINE 478
G L K++ G ++ GG + VK+VIP G A DG++ GD ++ +N
Sbjct: 1345 GDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 1404
Query: 479 VCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMV 538
V + G TH V+ ++ GQ V+L+L +G + P + P+ P +
Sbjct: 1405 VSLEGATHKQAVETLRNT--GQVVHLLLEKG-------QSPTSKEHVPVT-----PQCTL 1450
Query: 539 NGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGA 598
+ ++ E + +T+Q V D +S T+ + T+ + ++ + S +
Sbjct: 1451 SDQNAQGQGPEKVKKTTQ-VKD---------YSFVTE---ENTFEVKLFKNSSGLGFSFS 1497
Query: 599 TQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLS 658
+ L+ I P + K +D+ GD+I+++N +++ LS
Sbjct: 1498 REDNLIPEQINASIVRVKKLFPGQPAAESGK--IDV--------GDVILKVNGASLKGLS 1547
Query: 659 HTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLP 718
EV+ L+ E L++ R P P +D T+L P
Sbjct: 1548 QQEVISALRG--TAPEVFLLLCR-----PPPGVLPEID---------TALLTPLQSPAQV 1591
Query: 719 FPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKEL 777
P + SS P E D E+ +KS+ +S P R DSSG +L
Sbjct: 1592 LPNSSKDSSQPSCVE--QSTSSDENEMSDKSKKQCKS----PSRRDSYSDSSGSGEDDL 1644
Score = 47.4 bits (111), Expect = 1e-04
Identities = 45/157 (28%), Positives = 67/157 (42%), Gaps = 32/157 (20%)
Query: 1123 RQHSPDTRQYPLSDYR-------------QPQDFDY------FTVDMEKGAKGFGFSIRG 1163
++H P T Q LSD Q +D+ + F V + K + G GFS
Sbjct: 1439 KEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSF-- 1496
Query: 1164 GREYKMD--------LYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIK 1215
RE + + V +L PA +G++ VGD I+++NG S + ++ I ++
Sbjct: 1497 SREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1556
Query: 1216 SGGRRVRLLLKR-GTGQVPEYDEP--APWSSPAAAAP 1249
V LLL R G +PE D P SPA P
Sbjct: 1557 GTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLP 1593
Score = 47.4 bits (111), Expect = 1e-04
Identities = 33/101 (32%), Positives = 51/101 (50%), Gaps = 4/101 (3%)
Query: 419 QLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINE 478
+L+ L T +K GFT+ G++ V VI D PA DG+++ GD ++ +N+
Sbjct: 1763 ELEVELLITLIKSEKGSLGFTVTKGNQRIG-CYVHDVIQD-PAKSDGRLKPGDRLIKVND 1820
Query: 479 VCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDP 519
V TH D V L ++ ++V LV+ R LP P P
Sbjct: 1821 TDVTNMTHTDAVNLLRAA--SKTVRLVIGRVLELPRIPMLP 1859
Score = 44.3 bits (103), Expect = 9e-04
Identities = 51/196 (26%), Positives = 81/196 (41%), Gaps = 42/196 (21%)
Query: 859 RRKVLCGGEPCPENGRSPGSVSTHHSSPRSDY-----ATYTNSNHAAPSSNASPPEGFAS 913
R+ V+ EP P+ +H S RSD T N++ + S N SP
Sbjct: 982 RKNVIVNMEPPPQTVAELVGKPSHQMS-RSDAESLAGVTKLNNSKSVASLNRSPER--RK 1038
Query: 914 HSLQTSDV----------VIHRK-------ENE------------GFGFVIISSLNRPES 944
H +S + V+H++ E E G GF II E
Sbjct: 1039 HESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGG----EK 1094
Query: 945 GSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTL 1004
+ + I + G PAD LK GDR+++VN S+ + H ++++++A VTL
Sbjct: 1095 MGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTL 1154
Query: 1005 RII-PQEELNSPTSAP 1019
I P+E+++ S P
Sbjct: 1155 VISQPKEKISKVPSTP 1170
Score = 32.3 bits (72), Expect = 3.4
Identities = 20/63 (31%), Positives = 32/63 (50%), Gaps = 1/63 (1%)
Query: 428 TLKKSNMGFGFTIIGG-DEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTH 486
TL + GF++ GG D + + + + P AA +G ++ DVI Y+N V G T
Sbjct: 1866 TLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTL 1925
Query: 487 ADV 489
+V
Sbjct: 1926 EEV 1928
Score = 31.2 bits (69), Expect = 7.6
Identities = 14/47 (29%), Positives = 29/47 (61%), Gaps = 4/47 (8%)
Query: 633 DIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLII 679
D+ GC L GD ++ +N +++ +SH ++IL++ P + +L+I
Sbjct: 1114 DLDGC--LKPGDRLISVNSVSLEGVSHHAAIEILQNAP--EDVTLVI 1156
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 99.4 bits (246), Expect = 2e-20
Identities = 117/494 (23%), Positives = 203/494 (41%), Gaps = 89/494 (18%)
Query: 802 ILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRK 861
I + AVI G+A+ DGR+H GD ++ V+G+ + G TH+ ++ + + + + L
Sbjct: 1400 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL----- 1454
Query: 862 VLCGGEPCPENGRSPGSVSTHHSSPR---SDYATYTNSNHAAPSSNASPPEGFASHSLQT 918
E G+SP S +P+ SD + F + T
Sbjct: 1455 ---------EKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEE-NT 1504
Query: 919 SDVVIHRKENEGFGFVIISSLNR-PESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILA 977
+V + K + G GF N PE + V ++ ++ G PA K+ VGD IL
Sbjct: 1505 FEVKLF-KNSSGLGFSFSREDNLIPEQINASIV--RVKKLFPGQPAAESGKIDVGDVILK 1561
Query: 978 VNGQSIINMPHADIVKLIKDAGLSVTL-------RIIPQEE------LNSP--------- 1015
VNG S+ + +++ ++ V L ++P+ + L SP
Sbjct: 1562 VNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSK 1621
Query: 1016 -TSAPSSEKQSPMAQQSPLAQQSPLAQPSP--------------------------ATPN 1048
+S PS +QS + ++ ++ +S SP +T +
Sbjct: 1622 DSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWS 1681
Query: 1049 SPIAQPAPPQPLQLQGHENSYRSEVKARQDV----KPDIRQPPFTDYRQPPLDYRQPPGG 1104
S + Q Q Q H + +S+ + + +P F D PL PG
Sbjct: 1682 SALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQ 1741
Query: 1105 DYQQPPPLDYRQPPLLDYRQH--SPDTRQ---YPLSD--YRQPQDFDY---FTVDMEKGA 1154
Y QP + Y H S TRQ PL + +DF+ + + K
Sbjct: 1742 SY-QPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSE 1800
Query: 1155 KG-FGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIEL 1213
KG GF++ G + ++ YV + +D PA +GR++ GD++I++N +MTH A+ L
Sbjct: 1801 KGSLGFTVTKGNQ-RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNL 1858
Query: 1214 IKSGGRRVRLLLKR 1227
+++ + VRL++ R
Sbjct: 1859 LRAASKTVRLVIGR 1872
Score = 57.0 bits (136), Expect = 1e-07
Identities = 103/446 (23%), Positives = 172/446 (38%), Gaps = 96/446 (21%)
Query: 429 LKKSNMGFGFTIIGGDE--PDEF----LQVKSVIPDGPAAQDGKMETGDVIVYINEVCVL 482
L K++ G GF+ D P++ ++VK + P PAA+ GK++ GDVI+ +N +
Sbjct: 1509 LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLK 1568
Query: 483 GHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRH 542
G + +V+ + V L+LCR P D A ++ PL + P V+ N
Sbjct: 1569 GLSQQEVISALRGT--APEVFLLLCRPPPGVLPEIDTA--LLTPL---QSPAQVLPNSSK 1621
Query: 543 NYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAE 602
+ TS +++D+ S P D+ S SSG+ + +
Sbjct: 1622 DSSQPSCVEQSTSSDENEMSDKSKKQCKS-------------PSRRDSYS-DSSGSGEDD 1667
Query: 603 LMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEV 662
L+T I++S + Q L + Q SH E
Sbjct: 1668 LVTAPA---------NISNSTWSSALHQTL-----------------SNMVSQAQSHHE- 1700
Query: 663 VDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPA 722
P E ++ F+ P K P P+ S P+ P PP
Sbjct: 1701 ------APKSQEDTICTM---FYYPQKIP----------NKPEFEDSNPS-----PLPPD 1736
Query: 723 L-HRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYK---ELD 778
+ S+ +E+ D Y ++ S +RQ+ +++ D++ EL
Sbjct: 1737 MAPGQSYQPQSESASSSSMDKYHIHHISE---PTRQENWTPLKNDLENHLEDFELEVELL 1793
Query: 779 VHLRRMESG-FGFRILGGDEPGQPILIGAV---IAMGSADRDGRLHPGDELVYVDGIPVA 834
+ L + E G GF + G++ IG + A DGRL PGD L+ V+ V
Sbjct: 1794 ITLIKSEKGSLGFTVTKGNQ-----RIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVT 1848
Query: 835 GKTHRYVIDLMHHAARNGQVNLTVRR 860
TH ++L+ A++ V L + R
Sbjct: 1849 NMTHTDAVNLLRAASKT--VRLVIGR 1872
Score = 55.1 bits (131), Expect = 5e-07
Identities = 34/109 (31%), Positives = 56/109 (51%), Gaps = 10/109 (9%)
Query: 1140 PQDFDYFTVDMEKGAKGFGFSI-----RGGREYKM---DLYVLRLAEDGPAIRNGRMRVG 1191
P+ D F V++ K G S+ +GG + +YV + G A +GR+ G
Sbjct: 1361 PKPGDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKG 1420
Query: 1192 DQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAP 1240
D+++ +NG S TH +A+E +++ G+ V LLL++ GQ P E P
Sbjct: 1421 DRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEK--GQSPTSKEHVP 1467
Score = 52.4 bits (124), Expect = 3e-06
Identities = 51/194 (26%), Positives = 86/194 (44%), Gaps = 18/194 (9%)
Query: 673 SETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTS------LSAPAIPQNLPFPPALHRS 726
S+ SL HR + P + + S Q S L+ N +L+RS
Sbjct: 974 SQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRS 1033
Query: 727 SFPDSTEAFDPRKPDPYELYEKSRAIYES---RQQVPPRTSFRMDS-----SGPDYKELD 778
E+ DP + Y ++ S QVP + + + S P+ +
Sbjct: 1034 PERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITL 1093
Query: 779 VHLRR-MESGFGFRILGGDEPGQ---PILIGAVIAMGSADRDGRLHPGDELVYVDGIPVA 834
V+L++ + G GF+I+GG++ G+ I I +V G AD DG L PGD L+ V+ + +
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153
Query: 835 GKTHRYVIDLMHHA 848
G +H I+++ +A
Sbjct: 1154 GVSHHAAIEILQNA 1167
Score = 50.4 bits (119), Expect = 1e-05
Identities = 28/80 (35%), Positives = 46/80 (57%), Gaps = 5/80 (6%)
Query: 430 KKSNMGFGFTIIGGDEP---DEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTH 486
K + G GF IIGG++ D + + SV P GPA DG ++ GD ++ +N V + G +H
Sbjct: 1098 KDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 1157
Query: 487 ADVVKLFQSVPIGQSVNLVL 506
+++ Q+ P + V LV+
Sbjct: 1158 HAAIEILQNAP--EDVTLVI 1175
Score = 48.5 bits (114), Expect = 5e-05
Identities = 28/84 (33%), Positives = 52/84 (61%), Gaps = 4/84 (4%)
Query: 1148 VDMEKGAK-GFGFSIRGGREY-KMDL--YVLRLAEDGPAIRNGRMRVGDQIIEINGESTR 1203
V+++K AK G GF I GG + ++DL ++ +A GPA +G ++ GD++I +N S
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153
Query: 1204 DMTHARAIELIKSGGRRVRLLLKR 1227
++H AIE++++ V L++ +
Sbjct: 1154 GVSHHAAIEILQNAPEDVTLVISQ 1177
Score = 47.4 bits (111), Expect = 1e-04
Identities = 45/157 (28%), Positives = 67/157 (42%), Gaps = 32/157 (20%)
Query: 1123 RQHSPDTRQYPLSDYR-------------QPQDFDY------FTVDMEKGAKGFGFSIRG 1163
++H P T Q LSD Q +D+ + F V + K + G GFS
Sbjct: 1463 KEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSF-- 1520
Query: 1164 GREYKMD--------LYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIK 1215
RE + + V +L PA +G++ VGD I+++NG S + ++ I ++
Sbjct: 1521 SREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1580
Query: 1216 SGGRRVRLLLKR-GTGQVPEYDEP--APWSSPAAAAP 1249
V LLL R G +PE D P SPA P
Sbjct: 1581 GTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLP 1617
Score = 47.4 bits (111), Expect = 1e-04
Identities = 33/101 (32%), Positives = 51/101 (50%), Gaps = 4/101 (3%)
Query: 419 QLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINE 478
+L+ L T +K GFT+ G++ V VI D PA DG+++ GD ++ +N+
Sbjct: 1787 ELEVELLITLIKSEKGSLGFTVTKGNQRIG-CYVHDVIQD-PAKSDGRLKPGDRLIKVND 1844
Query: 479 VCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDP 519
V TH D V L ++ ++V LV+ R LP P P
Sbjct: 1845 TDVTNMTHTDAVNLLRAA--SKTVRLVIGRVLELPRIPMLP 1883
Score = 44.7 bits (104), Expect = 7e-04
Identities = 75/328 (22%), Positives = 132/328 (40%), Gaps = 59/328 (17%)
Query: 450 LQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRG 509
+ VK+VIP G A DG++ GD ++ +N V + G TH V+ ++ GQ V+L+L +G
Sbjct: 1400 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT--GQVVHLLLEKG 1457
Query: 510 YPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSL 569
+ P + P+ P ++ ++ E + +T+Q V D
Sbjct: 1458 -------QSPTSKEHVPVT-----PQCTLSDQNAQGQGPEKVKKTTQ-VKD--------- 1495
Query: 570 HSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTIADSPTGQRVK 629
+S T+ + T+ + ++ + S + + L+ I P + K
Sbjct: 1496 YSFVTE---ENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGK 1552
Query: 630 QILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWK 689
+D+ GD+I+++N +++ LS EV+ L+ E L++ R P
Sbjct: 1553 --IDV--------GDVILKVNGASLKGLSQQEVISALRG--TAPEVFLLLCR-----PPP 1595
Query: 690 TPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKS 749
P +D T+L P P + SS P E D E+ +KS
Sbjct: 1596 GVLPEID---------TALLTPLQSPAQVLPNSSKDSSQPSCVE--QSTSSDENEMSDKS 1644
Query: 750 RAIYESRQQVPPRTSFRMDSSGPDYKEL 777
+ +S P R DSSG +L
Sbjct: 1645 KKQCKS----PSRRDSYSDSSGSGEDDL 1668
Score = 43.1 bits (100), Expect = 0.002
Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 5/91 (5%)
Query: 930 GFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHA 989
G GF II E + + I + G PAD LK GDR+++VN S+ + H
Sbjct: 1103 GLGFQIIGG----EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHH 1158
Query: 990 DIVKLIKDAGLSVTLRII-PQEELNSPTSAP 1019
++++++A VTL I P+E+++ S P
Sbjct: 1159 AAIEILQNAPEDVTLVISQPKEKISKVPSTP 1189
Score = 32.3 bits (72), Expect = 3.4
Identities = 20/63 (31%), Positives = 32/63 (50%), Gaps = 1/63 (1%)
Query: 428 TLKKSNMGFGFTIIGG-DEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTH 486
TL + GF++ GG D + + + + P AA +G ++ DVI Y+N V G T
Sbjct: 1890 TLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTL 1949
Query: 487 ADV 489
+V
Sbjct: 1950 EEV 1952
Score = 31.2 bits (69), Expect = 7.6
Identities = 14/47 (29%), Positives = 29/47 (61%), Gaps = 4/47 (8%)
Query: 633 DIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLII 679
D+ GC L GD ++ +N +++ +SH ++IL++ P + +L+I
Sbjct: 1133 DLDGC--LKPGDRLISVNSVSLEGVSHHAAIEILQNAP--EDVTLVI 1175
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 91.7 bits (226), Expect = 5e-18
Identities = 145/658 (22%), Positives = 251/658 (38%), Gaps = 129/658 (19%)
Query: 430 KKSNMGFGFTIIGGDEPDEFLQ---------VKSVIPDGPAAQDGKMETGDVIVYINEVC 480
++ N+ G +I+GG + L+ +K V+ D PA + ++TGD I+ ++ V
Sbjct: 1073 REPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVD 1132
Query: 481 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG 540
+ +H++ V+ ++ G P+ F + + S P + + G
Sbjct: 1133 LQNASHSEAVEAIKNA------------GNPVVFIVQ--SLSSTPRVIPNVHNKANKITG 1178
Query: 541 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ 600
N +T + R + P + PP+ TD + D + +
Sbjct: 1179 NQNQDTQEKKEKRQGTAPPPMKLPPPYKAL---TDDSDENEEEDAFTDQKIRQRYADLP- 1234
Query: 601 AELMTLTIVKGAQGFGFTIADSPTGQRVKQI---LDIQGCPGLCEG-----DLIVEINQQ 652
EL + + K G G ++A + R+ ++ +G P +G D ++EIN Q
Sbjct: 1235 GELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEG-PAAADGRMRIGDELLEINNQ 1293
Query: 653 NVQNLSHTEVVDILKDCPIGSETSLIIHRGG----------FFSPWKTPKPIMDRW---- 698
+ SH I+K P S+ L+ R F P +P I D+
Sbjct: 1294 ILYGRSHQNASAIIKTAP--SKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEP 1351
Query: 699 ---ENQGSPQTSLSAPAIPQNLPFPPA---LHRSSFPDSTEAFDPRKP-DPYELYEKSRA 751
E GS + + +P++ F A + + +P P P Y + A
Sbjct: 1352 ISSEEDGSVEVGIKQ--LPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDA 1409
Query: 752 IY------ESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGG-DEPGQPILI 804
+ ++ V P T + +E+ + + + SG G I+GG D P I+I
Sbjct: 1410 DFTGYGGFQAPLSVDPATCPIVPG-----QEMIIEISKGRSGLGLSIVGGKDTPLNAIVI 1464
Query: 805 GAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLC 864
V G+A RDGRL GD+++ V+G+ + +H I + + +V L V R
Sbjct: 1465 HEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQ--KVRLVVYR---- 1518
Query: 865 GGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIH 924
D A Y + +L+ V +
Sbjct: 1519 ------------------------DEAHYRD-----------------EENLEIFPVDLQ 1537
Query: 925 RKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSII 984
+K G G I+ N GS + I I+ G AD +L GD+IL+VNG+ +
Sbjct: 1538 KKAGRGLGLSIVGKRN----GSGVF----ISDIVKGGAADLDGRLIQGDQILSVNGEDMR 1589
Query: 985 NMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQP 1042
N + ++K A V L I + S TSA ++ + S +QQS + P P
Sbjct: 1590 NASQETVATILKCAQGLVQLE-IGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAP 1646
Score = 83.6 bits (205), Expect = 1e-15
Identities = 82/333 (24%), Positives = 137/333 (41%), Gaps = 66/333 (19%)
Query: 921 VVIHRKENEGFGFVIISS---LNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILA 977
V I R+ N G I+ + R ++G + I ++++ SPA + LK GD+IL
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIF-IKQVLEDSPAGKTNALKTGDKILE 1127
Query: 978 VNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQS 1037
V+G + N H++ V+ IK+AG V I Q ++P P+ ++ +
Sbjct: 1128 VSGVDLQNASHSEAVEAIKNAGNPVV--FIVQSLSSTPRVIPNVHNKANKITGNQNQDTQ 1185
Query: 1038 PLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLD 1097
+ T P+ P P + L EN E A D K IRQ
Sbjct: 1186 EKKEKRQGTAPPPMKLPPPYKALTDDSDEN---EEEDAFTDQK--IRQ-----------R 1229
Query: 1098 YRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGF 1157
Y PG + +++EK G
Sbjct: 1230 YADLPG----------------------------------------ELHIIELEKDKNGL 1249
Query: 1158 GFSIRGGRE-YKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKS 1216
G S+ G ++ +M ++V+ + +GPA +GRMR+GD+++EIN + +H A +IK+
Sbjct: 1250 GLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKT 1309
Query: 1217 GGRRVRLLLKR---GTGQVPEYDEPAPWSSPAA 1246
+V+L+ R Q+ P P SSP++
Sbjct: 1310 APSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSS 1342
Score = 81.3 bits (199), Expect = 6e-15
Identities = 97/489 (19%), Positives = 188/489 (38%), Gaps = 54/489 (11%)
Query: 791 RILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAAR 850
R+ G+E + I I V+ A + L GD+++ V G+ + +H ++ + +A
Sbjct: 1092 RLKNGEEL-KGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA-- 1148
Query: 851 NGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEG 910
G + + + + P ++ + + + P P +
Sbjct: 1149 -GNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKA 1207
Query: 911 FASHSLQT------SDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGR-------- 956
S + +D I ++ + G + I L + ++G +++ R
Sbjct: 1208 LTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVV 1267
Query: 957 -IIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEE-LNS 1014
I PA ++++GD +L +N Q + H + +IK A V L I E+ +N
Sbjct: 1268 GINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQ 1327
Query: 1015 PTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQL---QGHENSYRS 1071
P S + + P++ + I Q + +L Q + Y +
Sbjct: 1328 MAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPT 1387
Query: 1072 EVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQ 1131
+V +I P + Y D+ G +Q P +D P++ ++
Sbjct: 1388 KVSFSSQ---EIPLAPASSYHSTDADFTGY--GGFQAPLSVDPATCPIVPGQE------- 1435
Query: 1132 YPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLR-LAEDGPAIRNGRMRV 1190
+++ KG G G SI GG++ ++ V+ + E+G A R+GR+
Sbjct: 1436 --------------MIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWA 1481
Query: 1191 GDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDE----PAPWSSPAA 1246
GDQI+E+NG R+ +H AI ++ ++VRL++ R + + P A
Sbjct: 1482 GDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAG 1541
Query: 1247 AAPGLPEVG 1255
GL VG
Sbjct: 1542 RGLGLSIVG 1550
Score = 79.7 bits (195), Expect = 2e-14
Identities = 109/494 (22%), Positives = 190/494 (38%), Gaps = 95/494 (19%)
Query: 778 DVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKT 837
+V L SG GF I+GG G +++ ++ G ADRDGRL GD ++ + G V G T
Sbjct: 248 EVELINDGSGLGFGIVGGKTSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMT 305
Query: 838 HRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSN 897
V ++ + + V + V R +P G +S +P +
Sbjct: 306 SEQVAQVLRNCGNS--VRMLVAR------DPA-------GDISVTPPAPAALPVALPTVA 350
Query: 898 HAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRI 957
P S++S +T +V + RK+ + G I+ + +G + K I
Sbjct: 351 SKGPGSDSS--------LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVK--SI 400
Query: 958 IDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTS 1017
I GS A ++V D+I+AV+G +I + D+V+++++AG V L ++ ++ +S
Sbjct: 401 IPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSS--- 457
Query: 1018 APSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQG------HENSYRS 1071
SPL PS + +P P L L G + +
Sbjct: 458 ------------------TSPLEPPS---DRGTVVEPLKPPALFLTGAVETETNVDGEDE 496
Query: 1072 EVKARQD-VKPD-------IRQPPFTDYRQPPLDYRQPPGGDYQ-QPPPLDYRQPPLLDY 1122
E+K R D +K D + + P + + + G DY+ LD + + D
Sbjct: 497 EIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQ---IADD 553
Query: 1123 RQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPA 1182
+ ++ P+ R + D F G Y+ + GP
Sbjct: 554 AELQKYSKLLPIHTLRLGVEVDSF----------------DGHH-----YISSIVSGGPV 592
Query: 1183 IRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWS 1242
G ++ D+++E+NG + A+ +K L+ R +D+ A
Sbjct: 593 DTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL-----FDDEASVD 647
Query: 1243 SPAAAAPGLPEVGV 1256
P LPE V
Sbjct: 648 EPRRTETSLPETEV 661
Score = 79.3 bits (194), Expect = 2e-14
Identities = 68/255 (26%), Positives = 112/255 (43%), Gaps = 11/255 (4%)
Query: 787 GFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMH 846
G G I+G G + I ++ G+AD DGRL GD+++ V+G + + V ++
Sbjct: 1543 GLGLSIVG-KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILK 1601
Query: 847 HAARNGQVNLTVRR-KVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNS--NHAAPSS 903
A G V L + R + + S GS + HSS +A N
Sbjct: 1602 CA--QGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKR 1659
Query: 904 NASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPA 963
+ P + + ++ V I+R+ ++ G I P +P I I A
Sbjct: 1660 VSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGD----IPVFIAMIQASGVA 1715
Query: 964 DRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEK 1023
R KLKVGDRI+++NGQ + + HAD+V L+K+A + L+++ + S +A
Sbjct: 1716 ARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNI-SAIAAQLENM 1774
Query: 1024 QSPMAQQSPLAQQSP 1038
+ SP A+ P
Sbjct: 1775 STGYHLGSPTAEHHP 1789
Score = 72.0 bits (175), Expect = 4e-12
Identities = 72/295 (24%), Positives = 120/295 (40%), Gaps = 38/295 (12%)
Query: 418 SQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEF-LQVKSVIPDGPAAQDGKMETGDVIVYI 476
+ L G L+K G G ++ G + + V + P+GPAA DG+M GD ++ I
Sbjct: 1231 ADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEI 1290
Query: 477 NEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGY---------PLPFDPEDPAN----SM 523
N + G +H + + ++ P V LV R P P P++ S
Sbjct: 1291 NNQILYGRSHQNASAIIKTAP--SKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSG 1348
Query: 524 VPPLA----------IMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMP 573
P++ I + P + +Y ++ S S +I P S HS
Sbjct: 1349 TEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTD 1408
Query: 574 TDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTIA---DSPTGQRVKQ 630
D G + P+ +V A+ + M + I KG G G +I D+P V
Sbjct: 1409 ADFTGYGGFQAPL---SVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIH 1465
Query: 631 ILDIQGCPG----LCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHR 681
+ +G L GD I+E+N +++N SH E + L+ P + L+++R
Sbjct: 1466 EVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTP--QKVRLVVYR 1518
Score = 65.5 bits (158), Expect = 4e-10
Identities = 129/588 (21%), Positives = 221/588 (37%), Gaps = 112/588 (19%)
Query: 435 GFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQ 494
G GF I+GG + V++++P G A +DG+++TGD I+ I V G T V ++ +
Sbjct: 257 GLGFGIVGGKTSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLR 314
Query: 495 SVPIGQSVNLVLCRGYPLPFDPEDPAN--SMVPPLAIMERPPPVMVNGRHNYETYLEYIS 552
+ G SV +++ R DPA S+ PP P + V
Sbjct: 315 N--CGNSVRMLVAR---------DPAGDISVTPP-----APAALPV-------------- 344
Query: 553 RTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGA 612
++P + + P S D L TY NV + + + V
Sbjct: 345 ----ALPTVASKGPGS------DSSLFETY-------NVELVRKDGQSLGIRIVGYV--- 384
Query: 613 QGFGFTIADSPTGQRVKQILDIQGCPGLCEG-----DLIVEINQQNVQNLSHTEVVDILK 667
G + +G VK I I G G D IV ++ N+Q ++ +VV++L+
Sbjct: 385 ---GTSHTGEASGIYVKSI--IPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLR 439
Query: 668 DCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSS 727
+ G L + R S +P DR ++ P P L A+ +
Sbjct: 440 NA--GQVVHLTLVRRKTSSSTSPLEPPSDR--------GTVVEPLKPPALFLTGAVETET 489
Query: 728 FPDS-----TEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKEL----- 777
D E D K D + EK + +S + S + GPDY+ +
Sbjct: 490 NVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPEN--ELKSRWENLLGPDYEVMVATLD 547
Query: 778 -----DVHLRRMESGFGFRIL----GGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYV 828
D L++ L D I ++++ G D G L P DEL+ V
Sbjct: 548 TQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEV 607
Query: 829 DGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRS 888
+G+ + GK+ R + + L R++ E R+ S+
Sbjct: 608 NGMQLYGKSRREAVSFLKEVP--PPFTLVCCRRLFDDEASVDEPRRTETSLPE------- 658
Query: 889 DYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTI 948
T +H + +G + +V K+ +G GF I+ + + ++
Sbjct: 659 -----TEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSV 713
Query: 949 TVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIK 996
V I ++ A+R L GDR+++VN + N A+ V+++K
Sbjct: 714 IV---IRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILK 758
Score = 56.6 bits (135), Expect = 2e-07
Identities = 120/530 (22%), Positives = 195/530 (36%), Gaps = 108/530 (20%)
Query: 418 SQLKGTFLSTTLKKSNMGFGFTIIG-------GDEPDEFLQVKSVIPDGPAAQDGKMETG 470
S L T+ ++K G I+G G+ + VKS+IP A +G ++
Sbjct: 358 SSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASG--IYVKSIIPGSAAYHNGHIQVN 415
Query: 471 DVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCR----GYPLPFDPEDPANSMVPP 526
D IV ++ V + G + DVV++ ++ GQ V+L L R P +P ++V P
Sbjct: 416 DKIVAVDGVNIQGFANHDVVEVLRNA--GQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEP 473
Query: 527 LAIMERPPPVMVNGRHNYETYL----EYISRTSQSVPDITDRPPHSLHSMP--TDGQLDG 580
L +PP + + G ET + E I ++ + + L +P + +L
Sbjct: 474 L----KPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKS 529
Query: 581 TYPPPVHDDNVSMASSGATQ----AELMTLTIVKGAQGFGFTI-ADSPTGQRVKQILDIQ 635
+ + D M ++ TQ AEL + + + DS G + +
Sbjct: 530 RWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSI-VS 588
Query: 636 GCP----GLCE-GDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKT 690
G P GL + D ++E+N + S E V LK+ P
Sbjct: 589 GGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVP-------------------- 628
Query: 691 PKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSR 750
PF R F D +PR+ E S
Sbjct: 629 --------------------------PPFTLVCCRRLFDDEASVDEPRRT------ETSL 656
Query: 751 AIYESRQQVPPRTSFRMDSS----GPDYKELDVHLRRMESGFGFRILGGDEPGQP----I 802
E + T D P+ K V L + G GF IL +P P I
Sbjct: 657 PETEVDHNMDVNTEEDDDGELALWSPEVK--IVELVKDCKGLGFSILDYQDPLDPTRSVI 714
Query: 803 LIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKV 862
+I +++A G A+R G L PGD LV V+ + + ++++ A G V+L + + +
Sbjct: 715 VIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEIL-KAVPPGLVHLGICKPL 773
Query: 863 LCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSS-NASPPEGF 911
+ E S HSS D ++ + H SS P+GF
Sbjct: 774 VEDNE--------EESCYILHSSSNEDKTEFSGTIHDINSSLILEAPKGF 815
Score = 53.5 bits (127), Expect = 1e-06
Identities = 34/115 (29%), Positives = 56/115 (48%), Gaps = 3/115 (2%)
Query: 1148 VDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTH 1207
V++ G GF I GG+ + V + G A R+GR++ GD I++I G + + MT
Sbjct: 249 VELINDGSGLGFGIVGGKT--SGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTS 306
Query: 1208 ARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGL 1262
+ +++++ G VR+L+ R PAP + P A P + G D L
Sbjct: 307 EQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALP-VALPTVASKGPGSDSSL 360
Score = 49.3 bits (116), Expect = 3e-05
Identities = 29/92 (31%), Positives = 50/92 (54%), Gaps = 2/92 (2%)
Query: 1137 YRQPQDFDYFTVDMEKGA-KGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQII 1195
YR ++ + F VD++K A +G G SI G R +++ + + G A +GR+ GDQI+
Sbjct: 1523 YRDEENLEIFPVDLQKKAGRGLGLSIVGKRNGS-GVFISDIVKGGAADLDGRLIQGDQIL 1581
Query: 1196 EINGESTRDMTHARAIELIKSGGRRVRLLLKR 1227
+NGE R+ + ++K V+L + R
Sbjct: 1582 SVNGEDMRNASQETVATILKCAQGLVQLEIGR 1613
Score = 44.7 bits (104), Expect = 7e-04
Identities = 25/86 (29%), Positives = 47/86 (54%), Gaps = 4/86 (4%)
Query: 1142 DFDYFTVDMEKG-AKGFGFSIRGGREYKMD---LYVLRLAEDGPAIRNGRMRVGDQIIEI 1197
D + TV++ + + G SI GGR + +++ + G A R +++VGD+I+ I
Sbjct: 1671 DMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSI 1730
Query: 1198 NGESTRDMTHARAIELIKSGGRRVRL 1223
NG+ ++HA + L+K+ R+ L
Sbjct: 1731 NGQPLDGLSHADVVNLLKNAYGRIIL 1756
Score = 44.3 bits (103), Expect = 9e-04
Identities = 114/566 (20%), Positives = 190/566 (33%), Gaps = 145/566 (25%)
Query: 543 NYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPV---HDDNVSMASSGAT 599
+++ + + +T+ S+ I R P S + D T P V H + V + + G+
Sbjct: 198 SHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGS- 256
Query: 600 QAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPG----LCEGDLIVEINQQNVQ 655
G GF I T V + + G L GD I++I NVQ
Sbjct: 257 --------------GLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
Query: 656 NLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSA-PAIP 714
++ +V +L++C G+ +++ R P +S P P
Sbjct: 303 GMTSEQVAQVLRNC--GNSVRMLVAR---------------------DPAGDISVTPPAP 339
Query: 715 QNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDY 774
LP S P S + +E Y
Sbjct: 340 AALPVALPTVASKGPGSDSSL-------FETYNVEL------------------------ 368
Query: 775 KELDVHLRRMESGFGFRILG-------GDEPGQPILIGAVIAMGSADRDGRLHPGDELVY 827
+R+ G RI+G G+ G I + ++I +A +G + D++V
Sbjct: 369 ------VRKDGQSLGIRIVGYVGTSHTGEASG--IYVKSIIPGSAAYHNGHIQVNDKIVA 420
Query: 828 VDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPC-PENGRSP---------- 876
VDG+ + G + V++++ +A + + L VRRK P P + R
Sbjct: 421 VDGVNIQGFANHDVVEVLRNAGQVVHLTL-VRRKTSSSTSPLEPPSDRGTVVEPLKPPAL 479
Query: 877 ---GSVSTHHSSPRSDYA------TYTNSNHAAPSSNASPPEG----------------- 910
G+V T + D T N N A P+
Sbjct: 480 FLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDY 539
Query: 911 ---FASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCA 967
A+ Q +D +K ++ + I +L + H I I+ G P D
Sbjct: 540 EVMVATLDTQIADDAELQKYSK---LLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLG 596
Query: 968 KLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTL----RIIPQE-ELNSP----TSA 1018
L+ D +L VNG + + V +K+ TL R+ E ++ P TS
Sbjct: 597 LLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSL 656
Query: 1019 PSSEKQSPMAQQSPLAQQSPLAQPSP 1044
P +E M + LA SP
Sbjct: 657 PETEVDHNMDVNTEEDDDGELALWSP 682
Score = 37.4 bits (85), Expect = 0.11
Identities = 21/73 (28%), Positives = 40/73 (54%), Gaps = 4/73 (5%)
Query: 1148 VDMEKGAKGFGFSIRGGRE----YKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTR 1203
V++ K KG GFSI ++ + + + L DG A R+G + GD+++ +N
Sbjct: 687 VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLD 746
Query: 1204 DMTHARAIELIKS 1216
+ + A A+E++K+
Sbjct: 747 NTSLAEAVEILKA 759
Score = 36.2 bits (82), Expect = 0.24
Identities = 24/98 (24%), Positives = 45/98 (45%), Gaps = 9/98 (9%)
Query: 1171 LYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRL-LLKRGT 1229
+YV + A NG ++V D+I+ ++G + + + +E++++ G+ V L L++R T
Sbjct: 395 IYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKT 454
Query: 1230 GQVPEYDEP--------APWSSPAAAAPGLPEVGVSLD 1259
EP P PA G E ++D
Sbjct: 455 SSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVD 492
Score = 35.8 bits (81), Expect = 0.31
Identities = 30/106 (28%), Positives = 52/106 (49%), Gaps = 6/106 (5%)
Query: 917 QTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRIL 976
Q + I R G GF +++ ++ I V + GS ADR +LK D+IL
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKD----VQPGSVADRDQRLKENDQIL 186
Query: 977 AVNGQSI-INMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSS 1021
A+N + N+ H + L++ S+ L I+ +E +++ +S SS
Sbjct: 187 AINHTPLDQNISHQQAIALLQQTTGSLRL-IVAREPVHTKSSTSSS 231
Score = 35.8 bits (81), Expect = 0.31
Identities = 25/85 (29%), Positives = 48/85 (56%), Gaps = 5/85 (5%)
Query: 1148 VDMEKGAKG-FGFSIRGGREY---KMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGES-T 1202
+D+E+ + G GFS+ R K+D++V + A R+ R++ DQI+ IN
Sbjct: 135 IDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLD 194
Query: 1203 RDMTHARAIELIKSGGRRVRLLLKR 1227
++++H +AI L++ +RL++ R
Sbjct: 195 QNISHQQAIALLQQTTGSLRLIVAR 219
Score = 33.5 bits (75), Expect = 1.5
Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 3/73 (4%)
Query: 23 NPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDV 82
N LGF + GG +G + + PG +A G +L + + +L++ T V G+T V
Sbjct: 253 NDGSGLGFGIVGGKTSGVV--VRTIVPGGLADRDG-RLQTGDHILKIGGTNVQGMTSEQV 309
Query: 83 LAVIKHCKDPLRL 95
V+++C + +R+
Sbjct: 310 AQVLRNCGNSVRM 322
Score = 31.2 bits (69), Expect = 7.6
Identities = 17/37 (45%), Positives = 24/37 (64%)
Query: 459 GPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQS 495
G AA+ K++ GD IV IN + G +HADVV L ++
Sbjct: 1713 GVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKN 1749
Score = 31.2 bits (69), Expect = 7.6
Identities = 14/26 (53%), Positives = 19/26 (73%)
Query: 643 GDLIVEINQQNVQNLSHTEVVDILKD 668
GD IV IN Q + LSH +VV++LK+
Sbjct: 1724 GDRIVSINGQPLDGLSHADVVNLLKN 1749
>gi|156546890 WW and C2 domain containing 2 [Homo sapiens]
Length = 1192
Score = 88.2 bits (217), Expect = 5e-17
Identities = 41/79 (51%), Positives = 53/79 (67%), Gaps = 3/79 (3%)
Query: 303 PLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPE--ECKENELPYGWEKIDDP 360
PLP WE A G+V++IDHNT+ TSW+DPR + KP +C +ELP+GWE DP
Sbjct: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR-DRLTKPLSFADCVGDELPWGWEAGFDP 69
Query: 361 IYGTYYVDHINRRTQFENP 379
G YY+DHIN+ TQ E+P
Sbjct: 70 QIGVYYIDHINKTTQIEDP 88
Score = 35.0 bits (79), Expect = 0.53
Identities = 16/33 (48%), Positives = 19/33 (57%)
Query: 302 DPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPR 334
D LP WE + + VY+IDH KTT DPR
Sbjct: 57 DELPWGWEAGFDPQIGVYYIDHINKTTQIEDPR 89
>gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens]
Length = 1113
Score = 85.9 bits (211), Expect = 3e-16
Identities = 41/90 (45%), Positives = 59/90 (65%), Gaps = 4/90 (4%)
Query: 303 PLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPP--EECKENELPYGWEKIDDP 360
PLP+ WE A G+VY+IDH +TTSW+DPR + KP +C +ELP GWE+ DP
Sbjct: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR-DRYTKPLTFADCISDELPLGWEEAYDP 65
Query: 361 IYGTYYVDHINRRTQFENPVLEAKRKLQQH 390
G Y++DH + TQ E+P ++ +R+ Q+H
Sbjct: 66 QVGDYFIDHNTKTTQIEDPRVQWRRE-QEH 94
Score = 42.4 bits (98), Expect = 0.003
Identities = 20/34 (58%), Positives = 22/34 (64%)
Query: 302 DPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRL 335
D LP WE AY + YFIDHNTKTT DPR+
Sbjct: 53 DELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRV 86
Score = 33.5 bits (75), Expect = 1.5
Identities = 15/33 (45%), Positives = 19/33 (57%)
Query: 347 ENELPYGWEKIDDPIYGTYYVDHINRRTQFENP 379
E LP GWE+ D YY+DH NR T + +P
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
>gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens]
Length = 1118
Score = 85.9 bits (211), Expect = 3e-16
Identities = 41/90 (45%), Positives = 59/90 (65%), Gaps = 4/90 (4%)
Query: 303 PLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPP--EECKENELPYGWEKIDDP 360
PLP+ WE A G+VY+IDH +TTSW+DPR + KP +C +ELP GWE+ DP
Sbjct: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR-DRYTKPLTFADCISDELPLGWEEAYDP 65
Query: 361 IYGTYYVDHINRRTQFENPVLEAKRKLQQH 390
G Y++DH + TQ E+P ++ +R+ Q+H
Sbjct: 66 QVGDYFIDHNTKTTQIEDPRVQWRRE-QEH 94
Score = 42.4 bits (98), Expect = 0.003
Identities = 20/34 (58%), Positives = 22/34 (64%)
Query: 302 DPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRL 335
D LP WE AY + YFIDHNTKTT DPR+
Sbjct: 53 DELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRV 86
Score = 33.5 bits (75), Expect = 1.5
Identities = 15/33 (45%), Positives = 19/33 (57%)
Query: 347 ENELPYGWEKIDDPIYGTYYVDHINRRTQFENP 379
E LP GWE+ D YY+DH NR T + +P
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
>gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens]
Length = 1119
Score = 85.9 bits (211), Expect = 3e-16
Identities = 41/90 (45%), Positives = 59/90 (65%), Gaps = 4/90 (4%)
Query: 303 PLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPP--EECKENELPYGWEKIDDP 360
PLP+ WE A G+VY+IDH +TTSW+DPR + KP +C +ELP GWE+ DP
Sbjct: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR-DRYTKPLTFADCISDELPLGWEEAYDP 65
Query: 361 IYGTYYVDHINRRTQFENPVLEAKRKLQQH 390
G Y++DH + TQ E+P ++ +R+ Q+H
Sbjct: 66 QVGDYFIDHNTKTTQIEDPRVQWRRE-QEH 94
Score = 42.4 bits (98), Expect = 0.003
Identities = 20/34 (58%), Positives = 22/34 (64%)
Query: 302 DPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRL 335
D LP WE AY + YFIDHNTKTT DPR+
Sbjct: 53 DELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRV 86
Score = 33.5 bits (75), Expect = 1.5
Identities = 15/33 (45%), Positives = 19/33 (57%)
Query: 347 ENELPYGWEKIDDPIYGTYYVDHINRRTQFENP 379
E LP GWE+ D YY+DH NR T + +P
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
>gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens]
Length = 334
Score = 85.5 bits (210), Expect = 3e-16
Identities = 69/219 (31%), Positives = 104/219 (47%), Gaps = 55/219 (25%)
Query: 1145 YFTVDMEKGAKGFGFSIRGGREYKMD--LYVLRLAEDGPAIRNGRMRVGDQIIEINGEST 1202
+F+V++ +G GFG ++ GGR+ D L V L +DGPA R GR+ VGD ++ INGEST
Sbjct: 123 HFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 182
Query: 1203 RDMTHARAIELIKSGGRRVRLLLK----------RGTGQ-----VPEYDEPAPWSSPAAA 1247
+ +THA+A+E I++GG ++ L+++ RG G+ VP + + +P
Sbjct: 183 QGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSP------- 235
Query: 1248 APGLPEV--GVSLDDGLAPFSPS-----------HPAPPS---------------DPSHQ 1279
PG PEV S L PS P+P + DP+ Q
Sbjct: 236 DPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQ 295
Query: 1280 I--SPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRER 1316
I SPGP W + E + + + Q Q + R R
Sbjct: 296 IPGSPGP-WLVPSEERLSRALGVRGAAQLAQEMAAGRRR 333
Score = 55.1 bits (131), Expect = 5e-07
Identities = 47/137 (34%), Positives = 68/137 (49%), Gaps = 17/137 (12%)
Query: 385 RKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGD 444
R L+ N P + K AP KP SQ G F S L + GFG T+ GG
Sbjct: 95 RWLETCNAPPQLIQGKARSAP----KP------SQASGHF-SVELVRGYAGFGLTLGGGR 143
Query: 445 EP--DEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSV 502
+ D L V+ ++ DGPA + G++E GD++++IN G THA V+ ++ G +
Sbjct: 144 DVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAG--GPQL 201
Query: 503 NLVLCRGYPLPFDPEDP 519
+LV+ R PL P P
Sbjct: 202 HLVIRR--PLETHPGKP 216
Score = 43.9 bits (102), Expect = 0.001
Identities = 25/75 (33%), Positives = 39/75 (52%), Gaps = 3/75 (4%)
Query: 932 GFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADI 991
GF + R +G T P + ++ PA RC +L+VGD +L +NG+S + HA
Sbjct: 134 GFGLTLGGGRDVAGDT---PLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQA 190
Query: 992 VKLIKDAGLSVTLRI 1006
V+ I+ G + L I
Sbjct: 191 VERIRAGGPQLHLVI 205
Score = 42.4 bits (98), Expect = 0.003
Identities = 28/84 (33%), Positives = 45/84 (53%), Gaps = 4/84 (4%)
Query: 779 VHLRRMESGFGFRILGG-DEPGQ-PILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGK 836
V L R +GFG + GG D G P+ + ++ G A R GRL GD +++++G G
Sbjct: 126 VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL 185
Query: 837 THRYVIDLMHHAARNGQVNLTVRR 860
TH ++ + A Q++L +RR
Sbjct: 186 THAQAVERIR--AGGPQLHLVIRR 207
Score = 40.0 bits (92), Expect = 0.016
Identities = 49/196 (25%), Positives = 85/196 (43%), Gaps = 24/196 (12%)
Query: 549 EYISRTSQSVPDITD-RPPHS--LHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAE-LM 604
E +S + ++TD R PH+ + P L+ PP + ++ +QA
Sbjct: 65 EAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKARSAPKPSQASGHF 124
Query: 605 TLTIVKGAQGFGFTIA-------DSPTGQR-VKQILDIQGCPGLCEGDLIVEINQQNVQN 656
++ +V+G GFG T+ D+P R + + Q C L GDL++ IN ++ Q
Sbjct: 125 SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 184
Query: 657 LSHTEVVDILKDCPIGSETSLIIHR---------GGFFSPWKTPKPIM-DRWENQGSPQT 706
L+H + V+ ++ G + L+I R G P K P DR + G P+
Sbjct: 185 LTHAQAVERIR--AGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEV 242
Query: 707 SLSAPAIPQNLPFPPA 722
+ S + + PP+
Sbjct: 243 TGSRSSSTSLVQHPPS 258
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 84.7 bits (208), Expect = 6e-16
Identities = 178/723 (24%), Positives = 257/723 (35%), Gaps = 179/723 (24%)
Query: 775 KELDVHLRRMESGFGFRILGG--------DEPGQPILIGAVIAMGSADRDGRLHPGDELV 826
+EL + + R G G I GG D+ G I I V G A R G + GD+L+
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEG--IFISRVSEEGPAARAG-VRVGDKLL 781
Query: 827 YVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSP 886
V+G+ + G H ++ + A Q+ + R V PEN +V+ P
Sbjct: 782 EVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVE------PEN-----AVTITPLRP 830
Query: 887 RSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGS 946
DY+ PPE + L+ V + G GF I GS
Sbjct: 831 EDDYSPRERRGGGLRLP-LLPPE--SPGPLRQRHVACLARSERGLGFSIAGG-----KGS 882
Query: 947 TITVPHKIG-------RIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAG 999
T P++ G RI +G A R L+VGDR+L++NG + H V L+ A
Sbjct: 883 T---PYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAA- 938
Query: 1000 LSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQP 1059
SPT A E+++ P PP P
Sbjct: 939 --------------SPTIALLLEREA--------------------------GGPLPPSP 958
Query: 1060 LQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPL 1119
L H + PP + P P L P L
Sbjct: 959 LP---HSS------------------PPTAAVATTSITTATPG------VPGLPSLAPSL 991
Query: 1120 LDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMD--------L 1171
L P YP+ + R P + G SI GG ++ +
Sbjct: 992 LAAALEGP----YPVEEIRLP-----------RAGGPLGLSIVGGSDHSSHPFGVQEPGV 1036
Query: 1172 YVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQ 1231
++ ++ G A R+G +RVGD+I+ +NG+ RD TH A+ + + LL++R
Sbjct: 1037 FISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRR---- 1091
Query: 1232 VPEYDEPAPWSSPAAA---APGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISP-GPTWD 1287
+PAP APG +G+S+ G A +P P+D IS PT
Sbjct: 1092 -----DPAPPGLRELCIQKAPG-ERLGISIRGG-ARGHAGNPRDPTDEGIFISKVSPTGA 1144
Query: 1288 IKREHDVRKPKELSACGQKK---QRLGE--QRERSASP----------QRAARPRLEEAP 1332
R+ +R L Q+ GE Q RS + + LE +P
Sbjct: 1145 AGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSP 1204
Query: 1333 GGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGP 1392
G P A +++ D + GKE + G L GP A A
Sbjct: 1205 GVIANPFAAGIGHRNSLESISSIDRELSPEGPGKE--KELPGQTL--HWGPEATEA---- 1256
Query: 1393 GGGGSGALEAEGRAGARAGPRPG--PRPPGGAPARKAAVAP------GPWKVPGSDKLPS 1444
G G L+ + RA A A P G R P GA K A +P P P D+LP+
Sbjct: 1257 AGRGLQPLKLDYRALA-AVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPA 1315
Query: 1445 VLK 1447
+K
Sbjct: 1316 NVK 1318
Score = 58.5 bits (140), Expect = 4e-08
Identities = 95/431 (22%), Positives = 152/431 (35%), Gaps = 88/431 (20%)
Query: 600 QAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGC-------------PGLCEGDLI 646
+ E +TLTI++ G G +IA K D +G G+ GD +
Sbjct: 723 EEEELTLTILRQTGGLGISIAGGKGSTPYKG--DDEGIFISRVSEEGPAARAGVRVGDKL 780
Query: 647 VEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQT 706
+E+N +Q H E V+ L+ G+ + + R
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGA--GTAVQMRVWR------------------------- 813
Query: 707 SLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFR 766
R P++ P +P+ + R +PP
Sbjct: 814 -----------------ERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPP----- 851
Query: 767 MDSSGPDYKELDVHLRRMESGFGFRILGGDEP------GQPILIGAVIAMGSADRDGRLH 820
+S GP + L R E G GF I GG I + + G+A R G L
Sbjct: 852 -ESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQ 910
Query: 821 PGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVS 880
GD ++ ++G+ V H + + L+ A + + L + R+ G P S
Sbjct: 911 VGDRVLSINGVDVTEARHDHAVSLL--TAASPTIALLLEREA---------GGPLPPSPL 959
Query: 881 THHSSPRSDYAT--YTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEG--FGFVII 936
H S P + AT T + P + P A+ V R G G I+
Sbjct: 960 PHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIV 1019
Query: 937 SSLNRPESGSTITVPHK-IGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLI 995
+ + P I +++ A R L+VGDRILAVNGQ + + H + V +
Sbjct: 1020 GGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078
Query: 996 KDAGLSVTLRI 1006
L ++L +
Sbjct: 1079 LRPCLELSLLV 1089
Score = 51.6 bits (122), Expect = 5e-06
Identities = 63/262 (24%), Positives = 105/262 (40%), Gaps = 44/262 (16%)
Query: 429 LKKSNMGFGFTIIGGD------EPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVL 482
L +S G GF+I GG D + V + G A + G ++ GD ++ IN V V
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 483 GHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRH 542
H V L + ++ L+L E A +PP + PP
Sbjct: 925 EARHDHAVSLLTAA--SPTIALLL----------EREAGGPLPPSPLPHSSPPTAAVATT 972
Query: 543 NYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAE 602
+ I+ + VP + P L + L+G YP + + + +G
Sbjct: 973 S-------ITTATPGVPGLPSLAPSLLAA-----ALEGPYPV----EEIRLPRAGGP--- 1013
Query: 603 LMTLTIVKGAQGFGFTIADSPTGQRVKQIL--DIQGCPGLCEGDLIVEINQQNVQNLSHT 660
+ L+IV G+ G + ++L + GL GD I+ +N Q+V++ +H
Sbjct: 1014 -LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQ 1072
Query: 661 EVVD-ILKDCPIGSETSLIIHR 681
E V +L+ C E SL++ R
Sbjct: 1073 EAVSALLRPC---LELSLLVRR 1091
Score = 50.4 bits (119), Expect = 1e-05
Identities = 117/520 (22%), Positives = 191/520 (36%), Gaps = 74/520 (14%)
Query: 954 IGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELN 1013
I ++ A R +L+VG R+L VN QS++ + H + V+L++ G ++T+ + E +
Sbjct: 1136 ISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEAS 1195
Query: 1014 SPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQG---HENSYR 1070
+ + S + + ++ L S ++ + ++ P + +L G H
Sbjct: 1196 TDAALEVSPGVIANPFAAGIGHRNSLE--SISSIDRELSPEGPGKEKELPGQTLHWGPEA 1253
Query: 1071 SEVKAR--QDVKPDIRQ----PPFTDYRQPPLDY------RQPPGGDYQQPPPLDYRQPP 1118
+E R Q +K D R P ++ P P QQPP PP
Sbjct: 1254 TEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPP-----SPP 1308
Query: 1119 LLD---------YRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKM 1169
D YR + +P P+D A S R ++Y
Sbjct: 1309 SPDELPANVKQAYRAFAAVPTSHP------PEDAPAQPPTPGPAASPEQLSFRERQKY-F 1361
Query: 1170 DLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSG--GRRVRLLLKR 1227
+L V +GP R + D + ++ E R + RA L ++ G RL L
Sbjct: 1362 ELEVRVPQAEGPPKRVSLVGA-DDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDG 1420
Query: 1228 GT-GQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPS-------------HPAPP 1273
T G+ + DE PW+SP+ + P L G AP + P PP
Sbjct: 1421 ETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGG-APVRTAKAERRHQERLRVQSPEPP 1479
Query: 1274 SDPSHQISPGPTWDIKREH----DVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLE 1329
+ P +SP ++ E + K L + Q + R + R RL
Sbjct: 1480 A-PERALSPAELRALEAEKRALWRAARMKSLEQDALRAQMV-LSRSQEGRGTRGPLERLA 1537
Query: 1330 EAPGGQGRPEAGRPASE-----ARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPG 1384
EAP P + P + + +PG + D A+ R+ P + G + +G
Sbjct: 1538 EAPSPAPTP-SPTPVEDLGPQTSTSPGRLSPDFAEELRS---LEPSPSPGPQ--EEDGEV 1591
Query: 1385 AAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPA 1424
A P G G E +R RPG R G P+
Sbjct: 1592 ALVLLGRPSPGAVGP-EDVALCSSRRPVRPGRRGLGPVPS 1630
Score = 49.7 bits (117), Expect = 2e-05
Identities = 49/189 (25%), Positives = 86/189 (45%), Gaps = 18/189 (9%)
Query: 444 DEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVN 503
D DE + + V P G A +DG++ G ++ +N+ +LG TH + V+L +SV G ++
Sbjct: 1128 DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV--GDTLT 1185
Query: 504 LVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVP-DIT 562
+++C G F+ A V P ++ P + R++ E+ S P
Sbjct: 1186 VLVCDG----FEASTDAALEVSP-GVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEK 1240
Query: 563 DRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMA---SSGATQAELMTLTIVKGAQGFGFTI 619
+ P +LH P + G P+ D ++A S+G+ Q + GA G
Sbjct: 1241 ELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQ------RVPSGAAGGKMAE 1294
Query: 620 AD-SPTGQR 627
+ SP+GQ+
Sbjct: 1295 SPCSPSGQQ 1303
Score = 48.9 bits (115), Expect = 4e-05
Identities = 65/252 (25%), Positives = 101/252 (40%), Gaps = 35/252 (13%)
Query: 1158 GFSIRGGREYKMD---------LYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHA 1208
G SIRGG +++ +++ G A R+GR+RVG +++E+N +S +TH
Sbjct: 1112 GISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHG 1171
Query: 1209 RAIELIKSGGRRVRLLLKRG----TGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAP 1264
A++L++S G + +L+ G T E P ++P AA G S+
Sbjct: 1172 EAVQLLRSVGDTLTVLVCDGFEASTDAALEV-SPGVIANPFAAGIGHRNSLESISSIDRE 1230
Query: 1265 FSPSHPAPPSDPSHQISPGPT--WDIKREHDVRKPKELSACGQKKQRLG-EQRERSASPQ 1321
SP P + PG T W P+ A G+ Q L + R +A P
Sbjct: 1231 LSPEGPGKEKE-----LPGQTLHWG---------PEATEAAGRGLQPLKLDYRALAAVPS 1276
Query: 1322 RAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCR-R 1380
+ R+ G E+ S + P + + D A K+A RA A
Sbjct: 1277 AGSVQRVPSGAAGGKMAESPCSPSGQQPP---SPPSPDELPANVKQAYRAFAAVPTSHPP 1333
Query: 1381 EGPGAAPAFAGP 1392
E A P GP
Sbjct: 1334 EDAPAQPPTPGP 1345
Score = 34.3 bits (77), Expect = 0.90
Identities = 28/89 (31%), Positives = 38/89 (42%), Gaps = 10/89 (11%)
Query: 766 RMDSSGPDYKELDVHLRRMESGFGFRILGG---------DEPGQPILIGAVIAMGSADRD 816
R D + P +EL + E G I GG D + I I V G+A RD
Sbjct: 1090 RRDPAPPGLRELCIQKAPGER-LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRD 1148
Query: 817 GRLHPGDELVYVDGIPVAGKTHRYVIDLM 845
GRL G L+ V+ + G TH + L+
Sbjct: 1149 GRLRVGLRLLEVNQQSLLGLTHGEAVQLL 1177
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 84.7 bits (208), Expect = 6e-16
Identities = 178/723 (24%), Positives = 257/723 (35%), Gaps = 179/723 (24%)
Query: 775 KELDVHLRRMESGFGFRILGG--------DEPGQPILIGAVIAMGSADRDGRLHPGDELV 826
+EL + + R G G I GG D+ G I I V G A R G + GD+L+
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEG--IFISRVSEEGPAARAG-VRVGDKLL 781
Query: 827 YVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSP 886
V+G+ + G H ++ + A Q+ + R V PEN +V+ P
Sbjct: 782 EVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVE------PEN-----AVTITPLRP 830
Query: 887 RSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGS 946
DY+ PPE + L+ V + G GF I GS
Sbjct: 831 EDDYSPRERRGGGLRLP-LLPPE--SPGPLRQRHVACLARSERGLGFSIAGG-----KGS 882
Query: 947 TITVPHKIG-------RIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAG 999
T P++ G RI +G A R L+VGDR+L++NG + H V L+ A
Sbjct: 883 T---PYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAA- 938
Query: 1000 LSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQP 1059
SPT A E+++ P PP P
Sbjct: 939 --------------SPTIALLLEREA--------------------------GGPLPPSP 958
Query: 1060 LQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPL 1119
L H + PP + P P L P L
Sbjct: 959 LP---HSS------------------PPTAAVATTSITTATPG------VPGLPSLAPSL 991
Query: 1120 LDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMD--------L 1171
L P YP+ + R P + G SI GG ++ +
Sbjct: 992 LAAALEGP----YPVEEIRLP-----------RAGGPLGLSIVGGSDHSSHPFGVQEPGV 1036
Query: 1172 YVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQ 1231
++ ++ G A R+G +RVGD+I+ +NG+ RD TH A+ + + LL++R
Sbjct: 1037 FISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRR---- 1091
Query: 1232 VPEYDEPAPWSSPAAA---APGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISP-GPTWD 1287
+PAP APG +G+S+ G A +P P+D IS PT
Sbjct: 1092 -----DPAPPGLRELCIQKAPG-ERLGISIRGG-ARGHAGNPRDPTDEGIFISKVSPTGA 1144
Query: 1288 IKREHDVRKPKELSACGQKK---QRLGE--QRERSASP----------QRAARPRLEEAP 1332
R+ +R L Q+ GE Q RS + + LE +P
Sbjct: 1145 AGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSP 1204
Query: 1333 GGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGP 1392
G P A +++ D + GKE + G L GP A A
Sbjct: 1205 GVIANPFAAGIGHRNSLESISSIDRELSPEGPGKE--KELPGQTL--HWGPEATEA---- 1256
Query: 1393 GGGGSGALEAEGRAGARAGPRPG--PRPPGGAPARKAAVAP------GPWKVPGSDKLPS 1444
G G L+ + RA A A P G R P GA K A +P P P D+LP+
Sbjct: 1257 AGRGLQPLKLDYRALA-AVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPA 1315
Query: 1445 VLK 1447
+K
Sbjct: 1316 NVK 1318
Score = 58.5 bits (140), Expect = 4e-08
Identities = 95/431 (22%), Positives = 152/431 (35%), Gaps = 88/431 (20%)
Query: 600 QAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGC-------------PGLCEGDLI 646
+ E +TLTI++ G G +IA K D +G G+ GD +
Sbjct: 723 EEEELTLTILRQTGGLGISIAGGKGSTPYKG--DDEGIFISRVSEEGPAARAGVRVGDKL 780
Query: 647 VEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQT 706
+E+N +Q H E V+ L+ G+ + + R
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGA--GTAVQMRVWR------------------------- 813
Query: 707 SLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFR 766
R P++ P +P+ + R +PP
Sbjct: 814 -----------------ERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPP----- 851
Query: 767 MDSSGPDYKELDVHLRRMESGFGFRILGGDEP------GQPILIGAVIAMGSADRDGRLH 820
+S GP + L R E G GF I GG I + + G+A R G L
Sbjct: 852 -ESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQ 910
Query: 821 PGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVS 880
GD ++ ++G+ V H + + L+ A + + L + R+ G P S
Sbjct: 911 VGDRVLSINGVDVTEARHDHAVSLL--TAASPTIALLLEREA---------GGPLPPSPL 959
Query: 881 THHSSPRSDYAT--YTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEG--FGFVII 936
H S P + AT T + P + P A+ V R G G I+
Sbjct: 960 PHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIV 1019
Query: 937 SSLNRPESGSTITVPHK-IGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLI 995
+ + P I +++ A R L+VGDRILAVNGQ + + H + V +
Sbjct: 1020 GGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078
Query: 996 KDAGLSVTLRI 1006
L ++L +
Sbjct: 1079 LRPCLELSLLV 1089
Score = 51.6 bits (122), Expect = 5e-06
Identities = 63/262 (24%), Positives = 105/262 (40%), Gaps = 44/262 (16%)
Query: 429 LKKSNMGFGFTIIGGD------EPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVL 482
L +S G GF+I GG D + V + G A + G ++ GD ++ IN V V
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 483 GHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRH 542
H V L + ++ L+L E A +PP + PP
Sbjct: 925 EARHDHAVSLLTAA--SPTIALLL----------EREAGGPLPPSPLPHSSPPTAAVATT 972
Query: 543 NYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAE 602
+ I+ + VP + P L + L+G YP + + + +G
Sbjct: 973 S-------ITTATPGVPGLPSLAPSLLAA-----ALEGPYPV----EEIRLPRAGGP--- 1013
Query: 603 LMTLTIVKGAQGFGFTIADSPTGQRVKQIL--DIQGCPGLCEGDLIVEINQQNVQNLSHT 660
+ L+IV G+ G + ++L + GL GD I+ +N Q+V++ +H
Sbjct: 1014 -LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQ 1072
Query: 661 EVVD-ILKDCPIGSETSLIIHR 681
E V +L+ C E SL++ R
Sbjct: 1073 EAVSALLRPC---LELSLLVRR 1091
Score = 49.7 bits (117), Expect = 2e-05
Identities = 49/189 (25%), Positives = 86/189 (45%), Gaps = 18/189 (9%)
Query: 444 DEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVN 503
D DE + + V P G A +DG++ G ++ +N+ +LG TH + V+L +SV G ++
Sbjct: 1128 DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV--GDTLT 1185
Query: 504 LVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVP-DIT 562
+++C G F+ A V P ++ P + R++ E+ S P
Sbjct: 1186 VLVCDG----FEASTDAALEVSP-GVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEK 1240
Query: 563 DRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMA---SSGATQAELMTLTIVKGAQGFGFTI 619
+ P +LH P + G P+ D ++A S+G+ Q + GA G
Sbjct: 1241 ELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQ------RVPSGAAGGKMAE 1294
Query: 620 AD-SPTGQR 627
+ SP+GQ+
Sbjct: 1295 SPCSPSGQQ 1303
Score = 49.7 bits (117), Expect = 2e-05
Identities = 112/517 (21%), Positives = 181/517 (35%), Gaps = 49/517 (9%)
Query: 954 IGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELN 1013
I ++ A R +L+VG R+L VN QS++ + H + V+L++ G ++T+ + E +
Sbjct: 1136 ISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEAS 1195
Query: 1014 SPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQG---HENSYR 1070
+ + S + + ++ L S ++ + ++ P + +L G H
Sbjct: 1196 TDAALEVSPGVIANPFAAGIGHRNSLE--SISSIDRELSPEGPGKEKELPGQTLHWGPEA 1253
Query: 1071 SEVKAR--QDVKPDIRQ----PPFTDYRQPPLDY------RQPPGGDYQQPPPLDYRQPP 1118
+E R Q +K D R P ++ P P QQPP PP
Sbjct: 1254 TEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPP-----SPP 1308
Query: 1119 LLD---------YRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKM 1169
D YR + +P P+D A S R ++Y
Sbjct: 1309 SPDELPANVKQAYRAFAAVPTSHP------PEDAPAQPPTPGPAASPEQLSFRERQKY-F 1361
Query: 1170 DLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSG--GRRVRLLLKR 1227
+L V +GP R + D + ++ E R + RA L ++ G RL L
Sbjct: 1362 ELEVRVPQAEGPPKRVSLVGA-DDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDG 1420
Query: 1228 GT-GQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTW 1286
T G+ + DE PW+SP+ + P L G + + SP P
Sbjct: 1421 ETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEP-- 1478
Query: 1287 DIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASE 1346
P EL A +K+ L + Q A R ++ + +GR G
Sbjct: 1479 --PAPERALSPAELRALEAEKRALWRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERL 1536
Query: 1347 ARAPGLAAADAADAARAGGKEAPRAAAGSELCRRE---GPGAAPAFAGPGGGGSGALEAE 1403
A AP A + G + + L ++ AA + P AE
Sbjct: 1537 AEAPSPAPTPSPTPVEDLGPQTSTSPGRLPLSGKKFDYRAFAALPSSRPVYDIQSPDFAE 1596
Query: 1404 GRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSD 1440
P PGP+ G A P P V D
Sbjct: 1597 ELRSLEPSPSPGPQEEDGEVALVLLGRPSPGAVGPED 1633
Score = 48.9 bits (115), Expect = 4e-05
Identities = 65/252 (25%), Positives = 101/252 (40%), Gaps = 35/252 (13%)
Query: 1158 GFSIRGGREYKMD---------LYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHA 1208
G SIRGG +++ +++ G A R+GR+RVG +++E+N +S +TH
Sbjct: 1112 GISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHG 1171
Query: 1209 RAIELIKSGGRRVRLLLKRG----TGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAP 1264
A++L++S G + +L+ G T E P ++P AA G S+
Sbjct: 1172 EAVQLLRSVGDTLTVLVCDGFEASTDAALEV-SPGVIANPFAAGIGHRNSLESISSIDRE 1230
Query: 1265 FSPSHPAPPSDPSHQISPGPT--WDIKREHDVRKPKELSACGQKKQRLG-EQRERSASPQ 1321
SP P + PG T W P+ A G+ Q L + R +A P
Sbjct: 1231 LSPEGPGKEKE-----LPGQTLHWG---------PEATEAAGRGLQPLKLDYRALAAVPS 1276
Query: 1322 RAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCR-R 1380
+ R+ G E+ S + P + + D A K+A RA A
Sbjct: 1277 AGSVQRVPSGAAGGKMAESPCSPSGQQPP---SPPSPDELPANVKQAYRAFAAVPTSHPP 1333
Query: 1381 EGPGAAPAFAGP 1392
E A P GP
Sbjct: 1334 EDAPAQPPTPGP 1345
Score = 34.3 bits (77), Expect = 0.90
Identities = 28/89 (31%), Positives = 38/89 (42%), Gaps = 10/89 (11%)
Query: 766 RMDSSGPDYKELDVHLRRMESGFGFRILGG---------DEPGQPILIGAVIAMGSADRD 816
R D + P +EL + E G I GG D + I I V G+A RD
Sbjct: 1090 RRDPAPPGLRELCIQKAPGER-LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRD 1148
Query: 817 GRLHPGDELVYVDGIPVAGKTHRYVIDLM 845
GRL G L+ V+ + G TH + L+
Sbjct: 1149 GRLRVGLRLLEVNQQSLLGLTHGEAVQLL 1177
>gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens]
Length = 262
Score = 84.7 bits (208), Expect = 6e-16
Identities = 67/209 (32%), Positives = 99/209 (47%), Gaps = 40/209 (19%)
Query: 1145 YFTVDMEKGAKGFGFSIRGGREYKMD--LYVLRLAEDGPAIRNGRMRVGDQIIEINGEST 1202
+F+V++ +G GFG ++ GGR+ D L V L +DGPA R GR+ VGD ++ INGEST
Sbjct: 56 HFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 115
Query: 1203 RDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAA-----PGLPEV--G 1255
+ +THA+A+E I++GG ++ L+++R P +P P PG PEV
Sbjct: 116 QGLTHAQAVERIRAGGPQLHLVIRRPLETHP--GKPRGVGEPRKGVDRSPDPGGPEVTGS 173
Query: 1256 VSLDDGLAPFSPS-----------HPAPPS---------------DPSHQI--SPGPTWD 1287
S L PS P+P + DP+ QI SPGP W
Sbjct: 174 RSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGP-WL 232
Query: 1288 IKREHDVRKPKELSACGQKKQRLGEQRER 1316
+ E + + + Q Q + R R
Sbjct: 233 VPSEERLSRALGVRGAAQLAQEMAAGRRR 261
Score = 57.4 bits (137), Expect = 1e-07
Identities = 41/120 (34%), Positives = 61/120 (50%), Gaps = 7/120 (5%)
Query: 418 SQLKGTFLSTTLKKSNMGFGFTIIGGDEP--DEFLQVKSVIPDGPAAQDGKMETGDVIVY 475
SQ G F S L + GFG T+ GG + D L V+ ++ DGPA + G++E GD++++
Sbjct: 51 SQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLH 109
Query: 476 INEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPP 535
IN G THA V+ ++ G ++LV+ R PL P P P + P P
Sbjct: 110 INGESTQGLTHAQAVERIRAG--GPQLHLVIRR--PLETHPGKPRGVGEPRKGVDRSPDP 165
Score = 43.9 bits (102), Expect = 0.001
Identities = 25/75 (33%), Positives = 39/75 (52%), Gaps = 3/75 (4%)
Query: 932 GFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADI 991
GF + R +G T P + ++ PA RC +L+VGD +L +NG+S + HA
Sbjct: 67 GFGLTLGGGRDVAGDT---PLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQA 123
Query: 992 VKLIKDAGLSVTLRI 1006
V+ I+ G + L I
Sbjct: 124 VERIRAGGPQLHLVI 138
Score = 42.7 bits (99), Expect = 0.003
Identities = 35/107 (32%), Positives = 52/107 (48%), Gaps = 11/107 (10%)
Query: 779 VHLRRMESGFGFRILGG-DEPGQ-PILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGK 836
V L R +GFG + GG D G P+ + ++ G A R GRL GD +++++G G
Sbjct: 59 VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL 118
Query: 837 THRYVIDLMHHAARNGQVNLTVRR-------KVLCGGEPCPENGRSP 876
TH ++ + A Q++L +RR K GEP RSP
Sbjct: 119 THAQAVERIR--AGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSP 163
Score = 42.0 bits (97), Expect = 0.004
Identities = 35/131 (26%), Positives = 62/131 (47%), Gaps = 15/131 (11%)
Query: 605 TLTIVKGAQGFGFTIA-------DSPTGQR-VKQILDIQGCPGLCEGDLIVEINQQNVQN 656
++ +V+G GFG T+ D+P R + + Q C L GDL++ IN ++ Q
Sbjct: 58 SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 117
Query: 657 LSHTEVVDILKDCPIGSETSLIIHRGGFFSPWK-----TPKPIMDRWENQGSPQTSLSAP 711
L+H + V+ ++ G + L+I R P K P+ +DR + G P+ + S
Sbjct: 118 LTHAQAVERIR--AGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRS 175
Query: 712 AIPQNLPFPPA 722
+ + PP+
Sbjct: 176 SSTSLVQHPPS 186
Score = 31.2 bits (69), Expect = 7.6
Identities = 44/176 (25%), Positives = 58/176 (32%), Gaps = 43/176 (24%)
Query: 1310 LGEQRERSASPQRAARPRLEEAPGGQ-GRPEAGRPASEARAP---GLAAADAADAARAGG 1365
LG R+ + A R L++ P + GR E G GL A A + RAGG
Sbjct: 72 LGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGG 131
Query: 1366 KEA--------------PRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAE-------- 1403
+ PR R+G +P GP GS +
Sbjct: 132 PQLHLVIRRPLETHPGKPRGVGEP----RKGVDRSPDPGGPEVTGSRSSSTSLVQHPPSR 187
Query: 1404 -GRAGARAGPRPGPR-----PPGGAPARKAAV-------APGPWKVPGSDKLPSVL 1446
R P P P P P R+A +PGPW VP ++L L
Sbjct: 188 TTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEERLSRAL 243
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 80.1 bits (196), Expect = 1e-14
Identities = 62/200 (31%), Positives = 82/200 (41%), Gaps = 29/200 (14%)
Query: 200 TDQILPGATPSAEGKRKRNKSVSNMEKASI--EPPEEEEEERPVVNGNGVVVTPESSEHE 257
T + PGA S + +N S + ++ EP + E P V G V +P ++
Sbjct: 207 TGEQSPGAR-SRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVG---VTSPPAAP-- 260
Query: 258 DKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYTEKGE 317
S + S P PA P E +E P + PD LP WE G
Sbjct: 261 -LSVTPNPNTTSLPAPAT----PAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGR 315
Query: 318 VYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFE 377
VY++DHNTKTT+W E LP GWEK DP YYVDH R T ++
Sbjct: 316 VYYVDHNTKTTTW----------------ERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQ 359
Query: 378 NPVLEAKRKLQQHNMPHTEL 397
P E R +Q +L
Sbjct: 360 RPTAEYVRNYEQWQSQRNQL 379
Score = 64.3 bits (155), Expect = 8e-10
Identities = 59/237 (24%), Positives = 84/237 (35%), Gaps = 44/237 (18%)
Query: 179 EDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEE-- 236
E + G PPA P + N LP AEG+ + A+ P
Sbjct: 247 EPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGW 306
Query: 237 EERPVVNGNGVVVT------------PESSEHEDKSAG-----------ASGEMPSQPYP 273
E+R + NG V P E G + + P+ Y
Sbjct: 307 EQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYV 366
Query: 274 APVYSQPEELKEQMDDT-----------KPTKPEDNEEPDPLPDNWEMAYTEKGEVYFID 322
Y Q + + Q+ + D++ PLP WE + G VY+++
Sbjct: 367 RN-YEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQ-DNGRVYYVN 424
Query: 323 HNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENP 379
HNT+TT W DPR + P LP GWE Y+VDH R T F++P
Sbjct: 425 HNTRTTQWEDPRTQGMIQEP------ALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 475
Score = 49.7 bits (117), Expect = 2e-05
Identities = 25/52 (48%), Positives = 34/52 (65%), Gaps = 7/52 (13%)
Query: 289 DTKPTKPEDN------EEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPR 334
+T+ T+ ED +EP LP WEM YT +G YF+DHNT+TT++ DPR
Sbjct: 426 NTRTTQWEDPRTQGMIQEP-ALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPR 476
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 78.6 bits (192), Expect = 4e-14
Identities = 67/262 (25%), Positives = 117/262 (44%), Gaps = 33/262 (12%)
Query: 775 KELDVHLRRMESGFGFRILGGDEP---GQPILIGAVIAMGSADRDGRLHPGDELVYVDGI 831
K L++ L++ G GF I D PI + ++ G+A +DGRL GD L+ V+G+
Sbjct: 458 KRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGV 517
Query: 832 PVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYA 891
+ GK+ V+ L+ G V+L V R+ E+ P ++ S +
Sbjct: 518 DLVGKSQEEVVSLLRSTKMEGTVSLLVFRQ---------EDAFHPRELNAEPSQMQIPKE 568
Query: 892 TYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVP 951
T A P+G + T +V ++ + G G V + E+ + + +
Sbjct: 569 T-----KAEDEDIVLTPDG--TREFLTFEVPLNDSGSAGLG-VSVKGNRSKENHADLGI- 619
Query: 952 HKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDA-----------GL 1000
+ II+G A + +L+V D+++AVNG+S++ + D ++ ++ + L
Sbjct: 620 -FVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQL 678
Query: 1001 SVTLRIIPQEELNSPTSAPSSE 1022
V RI EL SP S P E
Sbjct: 679 IVARRISKCNELKSPGSPPGPE 700
Score = 60.5 bits (145), Expect = 1e-08
Identities = 41/129 (31%), Positives = 70/129 (54%), Gaps = 15/129 (11%)
Query: 392 MPHTELGT-KPLQAPGFREKPLFTRDAS-----QLKGTFLSTTLKKSNMGFGFTI----- 440
+PH+ + KP AP + +F+ S + G L+ LKK G GF+I
Sbjct: 421 LPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDV 480
Query: 441 -IGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIG 499
IGG P + VK+++P G A QDG+++ GD ++ +N V ++G + +VV L +S +
Sbjct: 481 TIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKME 537
Query: 500 QSVNLVLCR 508
+V+L++ R
Sbjct: 538 GTVSLLVFR 546
Score = 52.4 bits (124), Expect = 3e-06
Identities = 77/343 (22%), Positives = 128/343 (37%), Gaps = 87/343 (25%)
Query: 560 DITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTI 619
D R PHS H + P V VS + + + + + KG +G GF+I
Sbjct: 416 DSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSI 475
Query: 620 A--DSPTGQR----VKQILD----IQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDC 669
D G VK IL IQ L GD ++E+N ++ S EVV +L+
Sbjct: 476 TSRDVTIGGSAPIYVKNILPRGAAIQD-GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Query: 670 PIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFP 729
+ SL++ R
Sbjct: 535 KMEGTVSLLVFR------------------------------------------------ 546
Query: 730 DSTEAFDPR----KPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRME 785
+AF PR +P ++ ++++A E P T ++ +V L
Sbjct: 547 -QEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTR--------EFLTFEVPLNDSG 597
Query: 786 S-GFGFRILGG----DEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY 840
S G G + G + I + ++I G+A +DGRL D+L+ V+G + GKT++
Sbjct: 598 SAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQD 657
Query: 841 VIDLMHHAA-----RNGQVNLTVRRKVLCGGEPCPENGRSPGS 878
++ + + + G + L V R++ C E +SPGS
Sbjct: 658 AMETLRRSMSTEGNKRGMIQLIVARRI----SKCNEL-KSPGS 695
Score = 52.0 bits (123), Expect = 4e-06
Identities = 38/132 (28%), Positives = 68/132 (51%), Gaps = 18/132 (13%)
Query: 1141 QDFDYFTVDM-EKGAKGFGFSIRGGREYK----MDLYVLRLAEDGPAIRNGRMRVGDQII 1195
++F F V + + G+ G G S++G R + + ++V + G A ++GR+RV DQ+I
Sbjct: 584 REFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLI 643
Query: 1196 EINGESTRDMTHARAIELIK-----SGGRR--VRLLLKRGTGQVPEYDEPAPWSSPAAAA 1248
+NGES T+ A+E ++ G +R ++L++ R + E P +
Sbjct: 644 AVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPG-----SPPG 698
Query: 1249 PGLPEVGVSLDD 1260
P LP + +LDD
Sbjct: 699 PELP-IETALDD 709
Score = 45.8 bits (107), Expect = 3e-04
Identities = 24/75 (32%), Positives = 41/75 (54%), Gaps = 9/75 (12%)
Query: 1148 VDMEKGAKGFGFSIR------GGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGES 1201
+ ++KG +G GFSI GG +YV + G AI++GR++ GD++IE+NG
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGG---SAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVD 518
Query: 1202 TRDMTHARAIELIKS 1216
+ + L++S
Sbjct: 519 LVGKSQEEVVSLLRS 533
Score = 37.0 bits (84), Expect = 0.14
Identities = 24/95 (25%), Positives = 45/95 (47%), Gaps = 4/95 (4%)
Query: 401 PLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGG----DEPDEFLQVKSVI 456
P + E + T D ++ TF + G G ++ G + D + VKS+I
Sbjct: 566 PKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSII 625
Query: 457 PDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVK 491
G A++DG++ D ++ +N +LG T+ D ++
Sbjct: 626 NGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAME 660
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 76.3 bits (186), Expect = 2e-13
Identities = 70/300 (23%), Positives = 123/300 (41%), Gaps = 53/300 (17%)
Query: 926 KENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIIN 985
K +G GF I + ++ + +IIDG A + +L+VGDR+L VN S+
Sbjct: 147 KGPKGLGFSIAGGVGNQHIPGDNSI--YVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 204
Query: 986 MPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPA 1045
+ H + V ++K+ V L++ PT+ ++ P
Sbjct: 205 VTHEEAVAILKNTSEVVYLKV------GKPTTIYMTDPYGP------------------- 239
Query: 1046 TPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGD 1105
P+ + P + L G+ + + PP + R P+ D
Sbjct: 240 -PDITHSYSPPMENHLLSGNNGTLEYKTSL----------PPISPGRYSPIPKHMLVDDD 288
Query: 1106 YQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQ-DFDYFTVDMEKGAKGFGFSIRGG 1164
Y + QHS TRQ ++ R + + V + KG+ G GF+I GG
Sbjct: 289 YTS-------------HSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG 335
Query: 1165 REYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLL 1224
+ + ++V + GPA +G ++ GDQI+ +NG R +H +A +K G+ V ++
Sbjct: 336 EDGE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 394
Score = 66.2 bits (160), Expect = 2e-10
Identities = 67/277 (24%), Positives = 113/277 (40%), Gaps = 40/277 (14%)
Query: 412 LFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGD-----EPDEFLQVKSVIPDGPAAQDGK 466
L+ R + T + L K G GF+I GG D + V +I G A +DG+
Sbjct: 128 LYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGR 187
Query: 467 METGDVIVYINEVCVLGHTHADVVKLFQS------VPIGQSVNLVLCRGYPLPFDPEDPA 520
++ GD ++ +N + TH + V + ++ + +G+ + + P+ P D
Sbjct: 188 LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTD----PYGPPDIT 243
Query: 521 NSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQS-VPD----ITDRPPHSLHSMPTD 575
+S PP ME NG Y+T L IS S +P D HS HS T
Sbjct: 244 HSYSPP---MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTAT- 299
Query: 576 GQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQ 635
++++ + + + E + + KG+ G GF I G+ + +
Sbjct: 300 -----------RQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILA 348
Query: 636 GCPG-----LCEGDLIVEINQQNVQNLSHTEVVDILK 667
G P L GD I+ +N +++ SH + LK
Sbjct: 349 GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 385
Score = 61.6 bits (148), Expect = 5e-09
Identities = 70/271 (25%), Positives = 107/271 (39%), Gaps = 61/271 (22%)
Query: 777 LDVHLRRMESGFGFRILGG----DEPGQ-PILIGAVIAMGSADRDGRLHPGDELVYVDGI 831
+++ L + G GF I GG PG I + +I G+A +DGRL GD L+ V+
Sbjct: 141 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 200
Query: 832 PVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVS--THHSSPRSD 889
+ TH + ++ + + V KV G+P P TH SP +
Sbjct: 201 SLEEVTHEEAVAILKNTSE------VVYLKV---GKPTTIYMTDPYGPPDITHSYSPPME 251
Query: 890 YATYTNSNHAAPSSNASPP----------------EGFASHSLQTS-------------- 919
+ +N + PP + + SHS ++
Sbjct: 252 NHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVS 311
Query: 920 ------DVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGD 973
VV+H K + G GF I+ E G I V I+ G PAD +L+ GD
Sbjct: 312 LEGEPRKVVLH-KGSTGLGFNIVGG----EDGEGIFVSF----ILAGGPADLSGELQRGD 362
Query: 974 RILAVNGQSIINMPHADIVKLIKDAGLSVTL 1004
+IL+VNG + H +K AG +VT+
Sbjct: 363 QILSVNGIDLRGASHEQAAAALKGAGQTVTI 393
Score = 60.1 bits (144), Expect = 2e-08
Identities = 27/91 (29%), Positives = 53/91 (58%), Gaps = 5/91 (5%)
Query: 1142 DFDYFTVDMEKGAKGFGFSIRGGREYKM-----DLYVLRLAEDGPAIRNGRMRVGDQIIE 1196
++++ + +E+G G GFSI GG + +++ ++ G A +GR+RV D I+
Sbjct: 42 EYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 101
Query: 1197 INGESTRDMTHARAIELIKSGGRRVRLLLKR 1227
+N +++H++A+E +K G VRL ++R
Sbjct: 102 VNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 132
Score = 60.1 bits (144), Expect = 2e-08
Identities = 64/262 (24%), Positives = 113/262 (43%), Gaps = 50/262 (19%)
Query: 603 LMTLTIVKGAQGFGFTIADSPTGQR--------VKQILD---IQGCPGLCEGDLIVEINQ 651
++ + + KG +G GF+IA Q V +I+D Q L GD ++ +N
Sbjct: 140 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 199
Query: 652 QNVQNLSHTEVVDILKDCP------IGSETSLIIHRGGFFSPWKTP------KPIMDRW- 698
+++ ++H E V ILK+ +G T++ + P+ P P M+
Sbjct: 200 YSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMT-----DPYGPPDITHSYSPPMENHL 254
Query: 699 --ENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESR 756
N G+ + S P I P H D T S + + +
Sbjct: 255 LSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYT----------------SHSQHSTA 298
Query: 757 QQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRD 816
+ P T R S + +++ +H + +G GF I+GG++ G+ I + ++A G AD
Sbjct: 299 TRQPSMTLQRAVSLEGEPRKVVLH--KGSTGLGFNIVGGED-GEGIFVSFILAGGPADLS 355
Query: 817 GRLHPGDELVYVDGIPVAGKTH 838
G L GD+++ V+GI + G +H
Sbjct: 356 GELQRGDQILSVNGIDLRGASH 377
Score = 55.5 bits (132), Expect = 4e-07
Identities = 40/142 (28%), Positives = 72/142 (50%), Gaps = 9/142 (6%)
Query: 1148 VDMEKGAKGFGFSIRGGREYKM-----DLYVLRLAEDGPAIRNGRMRVGDQIIEINGEST 1202
+ + KG KG GFSI GG + +YV ++ + G A ++GR++VGD+++ +N S
Sbjct: 143 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 202
Query: 1203 RDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGL 1262
++TH A+ ++K+ V L + + T + D P + +P + +S ++G
Sbjct: 203 EEVTHEEAVAILKNTSEVVYLKVGKPT-TIYMTDPYGPPDITHSYSPPMENHLLSGNNGT 261
Query: 1263 APFSPSHPAPPSDPSHQISPGP 1284
+ S PP P + SP P
Sbjct: 262 LEYKTS--LPPISPG-RYSPIP 280
Score = 54.3 bits (129), Expect = 8e-07
Identities = 33/102 (32%), Positives = 55/102 (53%), Gaps = 7/102 (6%)
Query: 416 DASQLKGTFLSTTLKKSNMGFGFTIIGG-DEP----DEFLQVKSVIPDGPAAQDGKMETG 470
+ ++++ F TL++ N G GF+I GG D P D + + +IP G AA+DG++
Sbjct: 37 NGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVN 96
Query: 471 DVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPL 512
D I+ +NEV V +H+ V+ + G V L + R P+
Sbjct: 97 DCILRVNEVDVSEVSHSKAVEALKEA--GSIVRLYVRRRRPI 136
Score = 48.9 bits (115), Expect = 4e-05
Identities = 32/113 (28%), Positives = 54/113 (47%), Gaps = 9/113 (7%)
Query: 408 REKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKM 467
R+ + + A L+G L K + G GF I+GG E E + V ++ GPA G++
Sbjct: 300 RQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSGEL 358
Query: 468 ETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPA 520
+ GD I+ +N + + G +H + GQ+V ++ + PED A
Sbjct: 359 QRGDQILSVNGIDLRGASHEQAAAALKGA--GQTVTII------AQYQPEDYA 403
Score = 46.6 bits (109), Expect = 2e-04
Identities = 36/130 (27%), Positives = 62/130 (47%), Gaps = 11/130 (8%)
Query: 739 KPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGG--- 795
+ + Y+L + A + +Q ++ + +Y+ ++ L R SG GF I GG
Sbjct: 8 RAENYQLLWDTIASLKQCEQAMQHAFIPVNGTEIEYEFEEITLERGNSGLGFSIAGGTDN 67
Query: 796 ----DEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARN 851
D+PG I I +I G+A DGRL D ++ V+ + V+ +H ++ + A
Sbjct: 68 PHIGDDPG--IFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA--G 123
Query: 852 GQVNLTVRRK 861
V L VRR+
Sbjct: 124 SIVRLYVRRR 133
Score = 43.5 bits (101), Expect = 0.001
Identities = 22/49 (44%), Positives = 30/49 (61%), Gaps = 1/49 (2%)
Query: 138 VPCTTRPHKEGEVPGVDYIFITVEDFMELE-KSGALLESGTYEDNYYGT 185
VP TTRP ++ EV G DY F+ + ME + + +E+G Y DN YGT
Sbjct: 588 VPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGT 636
Score = 33.1 bits (74), Expect = 2.0
Identities = 27/91 (29%), Positives = 43/91 (47%), Gaps = 13/91 (14%)
Query: 602 ELMTLTIVKGAQGFGFTIA---DSPTGQRVKQILDIQGCPG--------LCEGDLIVEIN 650
E +T+ +G G GF+IA D+P I + PG L D I+ +N
Sbjct: 44 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 103
Query: 651 QQNVQNLSHTEVVDILKDCPIGSETSLIIHR 681
+ +V +SH++ V+ LK+ GS L + R
Sbjct: 104 EVDVSEVSHSKAVEALKEA--GSIVRLYVRR 132
>gi|11141889 WW45 protein [Homo sapiens]
Length = 383
Score = 74.7 bits (182), Expect = 6e-13
Identities = 32/77 (41%), Positives = 46/77 (59%), Gaps = 11/77 (14%)
Query: 303 PLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIY 362
PLP W + +T +G Y+IDHNT TT W P L ++ PP GWE+++ +
Sbjct: 200 PLPPGWSVDWTMRGRKYYIDHNTNTTHWSHP-LEREGLPP----------GWERVESSEF 248
Query: 363 GTYYVDHINRRTQFENP 379
GTYYVDH N++ Q+ +P
Sbjct: 249 GTYYVDHTNKKAQYRHP 265
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 73.9 bits (180), Expect = 1e-12
Identities = 61/220 (27%), Positives = 86/220 (39%), Gaps = 27/220 (12%)
Query: 186 PKPPA-EPAPLLLN-VTDQILPGATPSAEGK---RKRNKSVSNMEKASIEPPEEEEEERP 240
PKP A EPA +N + P S G + N N ++E P +E
Sbjct: 230 PKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTS 289
Query: 241 VVNGNGVVVTPESSEHEDKSA---GASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPED 297
N + T E E +S S S + A QP+ MD + +
Sbjct: 290 SENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQPDGC---MDPVR--QQSG 344
Query: 298 NEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKI 357
N + LP WE G Y++DHNT+TT+W P+ LP GWE+
Sbjct: 345 NANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ--------------PLPPGWERR 390
Query: 358 DDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTEL 397
D YYVDH R T ++ P +E+ R +Q +L
Sbjct: 391 VDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQL 430
Score = 62.4 bits (150), Expect = 3e-09
Identities = 33/83 (39%), Positives = 40/83 (48%), Gaps = 6/83 (7%)
Query: 297 DNEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEK 356
+N+ PLP WE VYF++HNTKTT W DPR E LP GWE
Sbjct: 451 ENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQ------NEEPLPEGWEI 504
Query: 357 IDDPIYGTYYVDHINRRTQFENP 379
Y+VDH R T F++P
Sbjct: 505 RYTREGVRYFVDHNTRTTTFKDP 527
Score = 55.5 bits (132), Expect = 4e-07
Identities = 25/56 (44%), Positives = 37/56 (66%), Gaps = 5/56 (8%)
Query: 289 DTKPTKPEDN-----EEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKA 339
+TK T+ ED + +PLP+ WE+ YT +G YF+DHNT+TT++ DPR K +
Sbjct: 478 NTKTTQWEDPRTQGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSS 533
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 72.4 bits (176), Expect = 3e-12
Identities = 87/387 (22%), Positives = 150/387 (38%), Gaps = 48/387 (12%)
Query: 870 PENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDV-----VIH 924
P RS T H P++D A T SN S + +S L +V +
Sbjct: 279 PHLERSEVDRGTEHRIPKTD-APLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMEL 337
Query: 925 RKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSII 984
KE++G G + S I V ++ +G A R +L +GD +L +NG ++
Sbjct: 338 LKESDGLGIQVSGGRGSKRSPHAIVVT----QVKEGGAAHRDGRLSLGDELLVINGHLLV 393
Query: 985 NMPHADIVKLIKDAGLSVTLRIIPQEE-------LNSPTSAPSSEKQSPMAQQSPLAQQS 1037
+ H + V +++ A V L + +E L S + + ++ + Q
Sbjct: 394 GLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQE 453
Query: 1038 PLAQPSPATPNS-PIAQPAPPQPLQLQGHENSY---------RSEVKARQDVKPDI-RQP 1086
+ T +S A P +P + G E S +++K + + + R
Sbjct: 454 ADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLE 513
Query: 1087 PFTDYRQPPLDYRQP---------PGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDY 1137
+Y + + P G + P LD +Y TR +
Sbjct: 514 SVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQ-EYHIVKKSTRSLSTTQV 572
Query: 1138 R------QPQDFDYFTVDMEKGAKGFGFSIRGGREY---KMDLYVLRLAEDGPAIRNGRM 1188
+P + EKG KG GFSI GGR+ +M ++V + +G A +GR+
Sbjct: 573 ESPWRLIRPSVISIIGLYKEKG-KGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRL 631
Query: 1189 RVGDQIIEINGESTRDMTHARAIELIK 1215
+ GD+I+++NG + +T AI K
Sbjct: 632 KEGDEILDVNGIPIKGLTFQEAIHTFK 658
Score = 68.6 bits (166), Expect = 4e-11
Identities = 55/218 (25%), Positives = 97/218 (44%), Gaps = 26/218 (11%)
Query: 782 RRMESGFGFRILGG-DEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY 840
R+ SG GF + GG D + I + V + G+A ++G ++ GD L+ V+G +AG H
Sbjct: 2627 RKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGN 2686
Query: 841 VIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAA 900
V+ ++H A + + +++ + +P P + P T +
Sbjct: 2687 VLKVLHQAQLHKDALVVIKKGM---DQPRPSARQEPP----------------TANGKGL 2727
Query: 901 PSSNASPPEGFASHSLQTSDVVIHR--KENEGFGFVIISSLNRPESGSTITVPHKIGRII 958
S P E S+ D + K + G G SL+ +S T P I R+
Sbjct: 2728 LSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGL----SLDGGKSSVTGDGPLVIKRVY 2783
Query: 959 DGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIK 996
G A++ ++ GD ILA+NG+ ++ + H D ++K
Sbjct: 2784 KGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMK 2821
Score = 61.2 bits (147), Expect = 7e-09
Identities = 85/291 (29%), Positives = 126/291 (43%), Gaps = 48/291 (16%)
Query: 787 GFGFRILGGDE--PGQP-ILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVID 843
G GF I GG + GQ I + + GSA DGRL GDE++ V+GIP+ G T + I
Sbjct: 596 GLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIH 655
Query: 844 LMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSS 903
R+G LTVR K++ +P S TH S S N N + +S
Sbjct: 656 TFKQ-IRSGLFVLTVRTKLV-------SPSLTPCSTPTHMSRSAS-----PNFNTSGGAS 702
Query: 904 NASPPEGFASHSLQTS---------DVVIHRKENEGFGF-VIISSLNRPESGSTITVPHK 953
EG +S + + +V ++++ G G +L G I H
Sbjct: 703 AGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYI---HS 759
Query: 954 IGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVK----LIKDAGLSVTLRI--- 1006
+ GS A + L GD+IL VN +N+ HA + K L K V L I
Sbjct: 760 LA---PGSVAKMESNLSRGDQILEVNS---VNVRHAALSKVHAILSKCPPGPVRLVIGRH 813
Query: 1007 ----IPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQ 1053
+ ++E++ A S+ ++S A SP +PL PS A +S I++
Sbjct: 814 PNPKVSEQEMDE-VIARSTYQESKEANSSP-GLGTPLKSPSLAKKDSLISE 862
Score = 53.1 bits (126), Expect = 2e-06
Identities = 57/288 (19%), Positives = 112/288 (38%), Gaps = 23/288 (7%)
Query: 961 SPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRII--------PQEEL 1012
SPA + K+++ D IL++NGQ ++ + + L + + +I
Sbjct: 128 SPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFKHKAHSTY 187
Query: 1013 NSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSE 1072
N +S S ++P + + + P A AP + G E S
Sbjct: 188 NGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGCEVSSDPS 247
Query: 1073 VKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPP---LDYRQPPLLDYRQHSPDT 1129
+ P++ P ++ G ++ ++R P S D
Sbjct: 248 TELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAPLTTSNDK 307
Query: 1130 RQYPLSDYRQPQDFD---------YFTVDMEKGAKGFGFSIRGGREYKMD---LYVLRLA 1177
R++ Q D + +++ K + G G + GGR K + V ++
Sbjct: 308 RRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVK 367
Query: 1178 EDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLL 1225
E G A R+GR+ +GD+++ ING ++H A+ +++S V+L++
Sbjct: 368 EGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVV 415
Score = 49.7 bits (117), Expect = 2e-05
Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 5/100 (5%)
Query: 430 KKSNMGFGFTIIGG-DEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHAD 488
+K G GF++ GG D + + V V G A+Q+G M GD ++ +N + G H +
Sbjct: 2627 RKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGN 2686
Query: 489 VVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLA 528
V+K+ + + +V+ +G D P+ PP A
Sbjct: 2687 VLKVLHQAQLHKDALVVIKKG----MDQPRPSARQEPPTA 2722
Score = 47.8 bits (112), Expect = 8e-05
Identities = 57/260 (21%), Positives = 101/260 (38%), Gaps = 63/260 (24%)
Query: 430 KKSNMGFGFTIIGGDE---PDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTH 486
K+ G GF+I GG + + VK++ P+G AA+DG+++ GD I+ +N + + G T
Sbjct: 591 KEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTF 650
Query: 487 ADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYET 546
+ + F+ + G V V + + P L P + + N+ T
Sbjct: 651 QEAIHTFKQIRSGLFVLTVRTK-------------LVSPSLTPCSTPTHMSRSASPNFNT 697
Query: 547 YLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTL 606
G +G+ ++ + G +M +
Sbjct: 698 ----------------------SGGASAGGSDEGS------SSSLGRKTPGPKDRIVMEV 729
Query: 607 TIVKGAQ-GFG-----FTIADSPTGQRVKQILDIQGCPG--------LCEGDLIVEINQQ 652
T+ K + G G + +SP G + + PG L GD I+E+N
Sbjct: 730 TLNKEPRVGLGIGACCLALENSPPGIYIHSL-----APGSVAKMESNLSRGDQILEVNSV 784
Query: 653 NVQNLSHTEVVDILKDCPIG 672
NV++ + ++V IL CP G
Sbjct: 785 NVRHAALSKVHAILSKCPPG 804
Score = 47.4 bits (111), Expect = 1e-04
Identities = 30/121 (24%), Positives = 58/121 (47%), Gaps = 12/121 (9%)
Query: 921 VVIHRKENEGFGFVIISSLNRPESGSTITVPHKI--GRIIDGSPADRCAKLKVGDRILAV 978
+V++RKE G GF + +G T P I R+ A + + GD +L+V
Sbjct: 2623 IVLNRKEGSGLGFSV--------AGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSV 2674
Query: 979 NGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSP 1038
NG S+ + H +++K++ A L ++ ++ ++ P PS+ ++ P A L +
Sbjct: 2675 NGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQP--RPSARQEPPTANGKGLLSRKT 2732
Query: 1039 L 1039
+
Sbjct: 2733 I 2733
Score = 42.4 bits (98), Expect = 0.003
Identities = 39/145 (26%), Positives = 59/145 (40%), Gaps = 9/145 (6%)
Query: 721 PALHRSSFPDSTEAFDPRKPDPYELY-EKSRAIYESRQQVPPRTSFRMDSSGPDYKELDV 779
P L RS TE P+ P +K R + + G +K +
Sbjct: 279 PHLERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWK---M 335
Query: 780 HLRRMESGFGFRILGG---DEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGK 836
L + G G ++ GG I++ V G+A RDGRL GDEL+ ++G + G
Sbjct: 336 ELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGL 395
Query: 837 THRYVIDLMHHAARNGQVNLTVRRK 861
+H + ++ A G V L V K
Sbjct: 396 SHEEAVAILRSA--TGMVQLVVASK 418
Score = 42.0 bits (97), Expect = 0.004
Identities = 30/112 (26%), Positives = 50/112 (44%), Gaps = 12/112 (10%)
Query: 1146 FTVDMEKGAKGFGFSIRGGREYK-MDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRD 1204
F V K G GFS+ GG + + + V R+ G A + G M GD ++ +NG S
Sbjct: 2622 FIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAG 2681
Query: 1205 MTHARAIELIKSG--GRRVRLLLKRGTGQVPEYDEPAP---WSSPAAAAPGL 1251
+ H ++++ + +++K+G D+P P P A GL
Sbjct: 2682 LAHGNVLKVLHQAQLHKDALVVIKKG------MDQPRPSARQEPPTANGKGL 2727
Score = 41.2 bits (95), Expect = 0.007
Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 3/78 (3%)
Query: 425 LSTTLKKSNMGFGFTIIGGDEP---DEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCV 481
L + K++ G G ++ GG D L +K V G A Q G +E GD I+ IN +
Sbjct: 2749 LCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPL 2808
Query: 482 LGHTHADVVKLFQSVPIG 499
+G H D + +SVP G
Sbjct: 2809 VGLMHFDAWNIMKSVPEG 2826
Score = 37.4 bits (85), Expect = 0.11
Identities = 23/76 (30%), Positives = 39/76 (51%), Gaps = 3/76 (3%)
Query: 1144 DYFTVDMEKGAKGFGFSIRGGREYKMD---LYVLRLAEDGPAIRNGRMRVGDQIIEINGE 1200
D V++ K + G G S+ GG+ L + R+ + G A + G + GD+I+ ING+
Sbjct: 2747 DALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGK 2806
Query: 1201 STRDMTHARAIELIKS 1216
+ H A ++KS
Sbjct: 2807 PLVGLMHFDAWNIMKS 2822
Score = 34.3 bits (77), Expect = 0.90
Identities = 21/77 (27%), Positives = 35/77 (45%), Gaps = 3/77 (3%)
Query: 422 GTFLSTTLKKSNMGFGFTIIGG---DEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINE 478
G L K + G G + GG + V V G A +DG++ GD ++ IN
Sbjct: 330 GRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVING 389
Query: 479 VCVLGHTHADVVKLFQS 495
++G +H + V + +S
Sbjct: 390 HLLVGLSHEEAVAILRS 406
Score = 32.0 bits (71), Expect = 4.5
Identities = 22/75 (29%), Positives = 38/75 (50%), Gaps = 4/75 (5%)
Query: 28 LGFELKGGAE--NGQFP-YLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLA 84
LGF + GG + GQ ++ + P A E G +L + +L+VN P+ GLT ++ +
Sbjct: 597 LGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDG-RLKEGDEILDVNGIPIKGLTFQEAIH 655
Query: 85 VIKHCKDPLRLKCVK 99
K + L + V+
Sbjct: 656 TFKQIRSGLFVLTVR 670
Score = 31.2 bits (69), Expect = 7.6
Identities = 15/53 (28%), Positives = 31/53 (58%), Gaps = 9/53 (16%)
Query: 1157 FGFSIRGGREYKMD---------LYVLRLAEDGPAIRNGRMRVGDQIIEINGE 1200
+G RGG++ K ++V L ++ PA ++G++R+ D+I+ +NG+
Sbjct: 96 YGEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQ 148
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 72.0 bits (175), Expect = 4e-12
Identities = 44/122 (36%), Positives = 60/122 (49%), Gaps = 23/122 (18%)
Query: 268 PSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKT 327
P P P+P Y+ P KP+ LP WEM G +FIDHNTKT
Sbjct: 356 PQSPQPSP-YNSP-------------KPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKT 401
Query: 328 TSWLDPRL-------AKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPV 380
T+W DPRL +K + P + LP GWE+ T+Y+DH ++ TQ+E+P
Sbjct: 402 TTWEDPRLKFPVHMRSKTSLNPNDL--GPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 459
Query: 381 LE 382
L+
Sbjct: 460 LQ 461
Score = 43.5 bits (101), Expect = 0.001
Identities = 18/37 (48%), Positives = 21/37 (56%)
Query: 303 PLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKA 339
PLP WE G ++IDHN+K T W DPRL A
Sbjct: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPA 464
Score = 43.1 bits (100), Expect = 0.002
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 11/68 (16%)
Query: 279 QPEELKEQMDDTK-----------PTKPEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKT 327
Q EE +Q DD + ++ ++ P PLP WE G Y+++HN +T
Sbjct: 38 QDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRT 97
Query: 328 TSWLDPRL 335
T W P L
Sbjct: 98 TQWHRPSL 105
Score = 38.9 bits (89), Expect = 0.037
Identities = 19/39 (48%), Positives = 23/39 (58%)
Query: 343 EECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVL 381
EE LP GWE+ D + TYYV+H NR TQ+ P L
Sbjct: 67 EELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 38.9 bits (89), Expect = 0.037
Identities = 17/45 (37%), Positives = 22/45 (48%), Gaps = 10/45 (22%)
Query: 299 EEPDP----------LPDNWEMAYTEKGEVYFIDHNTKTTSWLDP 333
EEP P LP WE KG Y+++HN +TT+W P
Sbjct: 251 EEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295
Score = 36.2 bits (82), Expect = 0.24
Identities = 15/33 (45%), Positives = 21/33 (63%)
Query: 350 LPYGWEKIDDPIYGTYYVDHINRRTQFENPVLE 382
LP GWE+ D TYYV+H NR T + P+++
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQ 298
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 72.0 bits (175), Expect = 4e-12
Identities = 44/122 (36%), Positives = 60/122 (49%), Gaps = 23/122 (18%)
Query: 268 PSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKT 327
P P P+P Y+ P KP+ LP WEM G +FIDHNTKT
Sbjct: 457 PQSPQPSP-YNSP-------------KPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKT 502
Query: 328 TSWLDPRL-------AKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPV 380
T+W DPRL +K + P + LP GWE+ T+Y+DH ++ TQ+E+P
Sbjct: 503 TTWEDPRLKFPVHMRSKTSLNPNDL--GPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 560
Query: 381 LE 382
L+
Sbjct: 561 LQ 562
Score = 43.5 bits (101), Expect = 0.001
Identities = 18/37 (48%), Positives = 21/37 (56%)
Query: 303 PLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKA 339
PLP WE G ++IDHN+K T W DPRL A
Sbjct: 529 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPA 565
Score = 43.1 bits (100), Expect = 0.002
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 11/68 (16%)
Query: 279 QPEELKEQMDDTK-----------PTKPEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKT 327
Q EE +Q DD + ++ ++ P PLP WE G Y+++HN +T
Sbjct: 159 QDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRT 218
Query: 328 TSWLDPRL 335
T W P L
Sbjct: 219 TQWHRPSL 226
Score = 39.3 bits (90), Expect = 0.028
Identities = 36/140 (25%), Positives = 50/140 (35%), Gaps = 42/140 (30%)
Query: 236 EEERPVVNGNGVVVTP-ESSEHEDKSAGASGEMPSQPYPAPVYSQ--PEELKEQMDDTKP 292
E+ P + G V P E+ E AG S + P PA S+ P+EL E++
Sbjct: 257 EDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQ 316
Query: 293 TKPEDNEE-----------------------------PDP----------LPDNWEMAYT 313
P+ N E P P LP WE
Sbjct: 317 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKD 376
Query: 314 EKGEVYFIDHNTKTTSWLDP 333
KG Y+++HN +TT+W P
Sbjct: 377 AKGRTYYVNHNNRTTTWTRP 396
Score = 38.9 bits (89), Expect = 0.037
Identities = 19/39 (48%), Positives = 23/39 (58%)
Query: 343 EECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVL 381
EE LP GWE+ D + TYYV+H NR TQ+ P L
Sbjct: 188 EELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 226
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 72.0 bits (175), Expect = 4e-12
Identities = 44/122 (36%), Positives = 60/122 (49%), Gaps = 23/122 (18%)
Query: 268 PSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKT 327
P P P+P Y+ P KP+ LP WEM G +FIDHNTKT
Sbjct: 336 PQSPQPSP-YNSP-------------KPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKT 381
Query: 328 TSWLDPRL-------AKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPV 380
T+W DPRL +K + P + LP GWE+ T+Y+DH ++ TQ+E+P
Sbjct: 382 TTWEDPRLKFPVHMRSKTSLNPNDL--GPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 439
Query: 381 LE 382
L+
Sbjct: 440 LQ 441
Score = 43.5 bits (101), Expect = 0.001
Identities = 18/37 (48%), Positives = 21/37 (56%)
Query: 303 PLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKA 339
PLP WE G ++IDHN+K T W DPRL A
Sbjct: 408 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPA 444
Score = 43.1 bits (100), Expect = 0.002
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 11/68 (16%)
Query: 279 QPEELKEQMDDTK-----------PTKPEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKT 327
Q EE +Q DD + ++ ++ P PLP WE G Y+++HN +T
Sbjct: 38 QDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRT 97
Query: 328 TSWLDPRL 335
T W P L
Sbjct: 98 TQWHRPSL 105
Score = 39.3 bits (90), Expect = 0.028
Identities = 36/140 (25%), Positives = 50/140 (35%), Gaps = 42/140 (30%)
Query: 236 EEERPVVNGNGVVVTP-ESSEHEDKSAGASGEMPSQPYPAPVYSQ--PEELKEQMDDTKP 292
E+ P + G V P E+ E AG S + P PA S+ P+EL E++
Sbjct: 136 EDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQ 195
Query: 293 TKPEDNEE-----------------------------PDP----------LPDNWEMAYT 313
P+ N E P P LP WE
Sbjct: 196 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKD 255
Query: 314 EKGEVYFIDHNTKTTSWLDP 333
KG Y+++HN +TT+W P
Sbjct: 256 AKGRTYYVNHNNRTTTWTRP 275
Score = 38.9 bits (89), Expect = 0.037
Identities = 19/39 (48%), Positives = 23/39 (58%)
Query: 343 EECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVL 381
EE LP GWE+ D + TYYV+H NR TQ+ P L
Sbjct: 67 EELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 72.0 bits (175), Expect = 4e-12
Identities = 44/122 (36%), Positives = 60/122 (49%), Gaps = 23/122 (18%)
Query: 268 PSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKT 327
P P P+P Y+ P KP+ LP WEM G +FIDHNTKT
Sbjct: 336 PQSPQPSP-YNSP-------------KPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKT 381
Query: 328 TSWLDPRL-------AKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPV 380
T+W DPRL +K + P + LP GWE+ T+Y+DH ++ TQ+E+P
Sbjct: 382 TTWEDPRLKFPVHMRSKTSLNPNDL--GPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 439
Query: 381 LE 382
L+
Sbjct: 440 LQ 441
Score = 43.5 bits (101), Expect = 0.001
Identities = 18/37 (48%), Positives = 21/37 (56%)
Query: 303 PLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKA 339
PLP WE G ++IDHN+K T W DPRL A
Sbjct: 408 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPA 444
Score = 43.1 bits (100), Expect = 0.002
Identities = 21/68 (30%), Positives = 31/68 (45%), Gaps = 11/68 (16%)
Query: 279 QPEELKEQMDDTK-----------PTKPEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKT 327
Q EE +Q DD + ++ ++ P PLP WE G Y+++HN +T
Sbjct: 38 QDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRT 97
Query: 328 TSWLDPRL 335
T W P L
Sbjct: 98 TQWHRPSL 105
Score = 39.3 bits (90), Expect = 0.028
Identities = 36/140 (25%), Positives = 50/140 (35%), Gaps = 42/140 (30%)
Query: 236 EEERPVVNGNGVVVTP-ESSEHEDKSAGASGEMPSQPYPAPVYSQ--PEELKEQMDDTKP 292
E+ P + G V P E+ E AG S + P PA S+ P+EL E++
Sbjct: 136 EDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQ 195
Query: 293 TKPEDNEE-----------------------------PDP----------LPDNWEMAYT 313
P+ N E P P LP WE
Sbjct: 196 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKD 255
Query: 314 EKGEVYFIDHNTKTTSWLDP 333
KG Y+++HN +TT+W P
Sbjct: 256 AKGRTYYVNHNNRTTTWTRP 275
Score = 38.9 bits (89), Expect = 0.037
Identities = 19/39 (48%), Positives = 23/39 (58%)
Query: 343 EECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVL 381
EE LP GWE+ D + TYYV+H NR TQ+ P L
Sbjct: 67 EELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,792,323
Number of Sequences: 37866
Number of extensions: 4474666
Number of successful extensions: 33376
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 418
Number of HSP's successfully gapped in prelim test: 1523
Number of HSP's that attempted gapping in prelim test: 21188
Number of HSP's gapped (non-prelim): 11219
length of query: 1455
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1340
effective length of database: 13,892,928
effective search space: 18616523520
effective search space used: 18616523520
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.