Guide to the Human Genome
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Name: TNF Sequence: fasta or formatted (233aa) NCBI GI: 25952111
Description:

tumor necrosis factor alpha

Referenced in:

Macrophages and Monocytes
TNF and Related Signals

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             8.2         19           1
 C cysteine            1.7          4           1
 D aspartate           3.0          7           1
 E glutamate           6.9         16           2
 F phenylalanine       4.3         10           1
 G glycine             7.3         17           2
 H histidine           1.7          4           1
 I isoleucine          5.2         12           2
 K lysine              3.4          8           2
 L leucine            12.9         30           2
 M methionine          0.9          2           1
 N asparagine          3.0          7           1
 P proline             6.4         15           1
 Q glutamine           5.6         13           1
 R arginine            6.0         14           2
 S serine              8.6         20           3
 T threonine           4.3         10           2
 V valine              6.9         16           2
 W tryptophan          0.9          2           1
 Y tyrosine            3.0          7           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   tumor necrosis factor alpha 
LTA                   0.137   lymphotoxin alpha precursor 
LTA                   0.137   lymphotoxin alpha precursor 
TNFSF15               0.128   tumor necrosis factor (ligand) superfamily, member 1...
FASLG                 0.098   fas ligand 
TNFSF14               0.096   tumor necrosis factor ligand superfamily, member 14 ...
TNFSF14               0.096   tumor necrosis factor ligand superfamily, member 14 ...
LTB                   0.089   lymphotoxin-beta isoform a 
TNFSF11               0.052   tumor necrosis factor ligand superfamily, member 11 ...
TNFSF11               0.052   tumor necrosis factor ligand superfamily, member 11 i...
CD40LG                0.050   CD40 ligand 
TNFSF10               0.046   tumor necrosis factor (ligand) superfamily, member 10...
TNFSF13B              0.036   tumor necrosis factor superfamily, member 13b isofo...
TNFSF13               0.027   tumor necrosis factor ligand superfamily, member 13 ...
TNFSF13               0.027   tumor necrosis factor ligand superfamily, member 13 i...
TNFSF13               0.027   tumor necrosis factor ligand superfamily, member 13 ...
TNFSF12-TNFSF13       0.027   TNFSF12-TNFSF13 protein 
TNFSF13B              0.025   tumor necrosis factor superfamily, member 13b isoform...
LOC100293104          0.011   PREDICTED: hypothetical protein 
LOC100294380          0.011   PREDICTED: hypothetical protein 
LOC100287047          0.011   PREDICTED: hypothetical protein XP_002344159 
TNFSF8                0.009   tumor necrosis factor (ligand) superfamily, member 8 ...
CRKRS                 0.009   Cdc2-related kinase, arginine/serine-rich isoform 2...
CRKRS                 0.009   Cdc2-related kinase, arginine/serine-rich isoform 1...
GRM5                  0.007   glutamate receptor, metabotropic 5 isoform a precur...
GRM5                  0.007   glutamate receptor, metabotropic 5 isoform b precurso...
CEACAM1               0.007   carcinoembryonic antigen-related cell adhesion molec...
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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