Guide to the Human Genome
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Search of human proteins with 25777677

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|25777677 Ras association domain family 2 [Homo sapiens]
         (326 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|25777677 Ras association domain family 2 [Homo sapiens]            654   0.0  
gi|7661964 Ras association domain family 2 [Homo sapiens]             654   0.0  
gi|23510360 Ras association domain family 4 [Homo sapiens]            350   1e-96
gi|41393610 Ras association (RalGDS/AF-6) domain family 6 isofor...   229   2e-60
gi|29789443 Ras association (RalGDS/AF-6) domain family 6 isofor...   229   2e-60
gi|32996735 Ras association (RalGDS/AF-6) domain family 5 isofor...    73   3e-13
gi|32996731 Ras association (RalGDS/AF-6) domain family 5 isofor...    73   3e-13
gi|30039698 Ras association (RalGDS/AF-6) domain family member 3...    68   1e-11
gi|25777684 Ras association domain family 1 isoform D [Homo sapi...    62   9e-10
gi|25777682 Ras association domain family 1 isoform C [Homo sapi...    62   9e-10
gi|20149588 Ras association domain family 1 isoform A [Homo sapi...    62   9e-10
gi|25777680 Ras association domain family 1 isoform B [Homo sapi...    62   9e-10
gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithora...    44   3e-04
gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithora...    44   3e-04
gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithora...    41   0.001
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom...    38   0.011
gi|32996733 Ras association (RalGDS/AF-6) domain family 5 isofor...    33   0.26 
gi|205277394 coenzyme A synthase isoform c [Homo sapiens]              33   0.34 
gi|110227607 coenzyme A synthase isoform b [Homo sapiens]              33   0.34 
gi|110227605 coenzyme A synthase isoform a [Homo sapiens]              33   0.34 
gi|110227601 coenzyme A synthase isoform a [Homo sapiens]              33   0.34 
gi|110227603 coenzyme A synthase isoform a [Homo sapiens]              33   0.34 
gi|21361440 RAB3A interacting protein (rabin3)-like 1 [Homo sapi...    33   0.45 
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        32   1.0  
gi|148277037 AP2 associated kinase 1 [Homo sapiens]                    31   1.3  
gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens]                    31   1.3  
gi|148596992 heart alpha-kinase [Homo sapiens]                         31   1.3  
gi|50083293 coiled-coil domain containing 123 [Homo sapiens]           31   1.3  
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]    31   1.7  
gi|157785668 coiled-coil domain containing 39 [Homo sapiens]           30   2.2  

>gi|25777677 Ras association domain family 2 [Homo sapiens]
          Length = 326

 Score =  654 bits (1687), Expect = 0.0
 Identities = 326/326 (100%), Positives = 326/326 (100%)

Query: 1   MDYSHQTSLVPCGQDKYISKNELLLHLKTYNLYYEGQNLQLRHREEEDEFIVEGLLNISW 60
           MDYSHQTSLVPCGQDKYISKNELLLHLKTYNLYYEGQNLQLRHREEEDEFIVEGLLNISW
Sbjct: 1   MDYSHQTSLVPCGQDKYISKNELLLHLKTYNLYYEGQNLQLRHREEEDEFIVEGLLNISW 60

Query: 61  GLRRPIRLQMQDDNERIRPPPSSSSWHSGCNLGAQGTTLKPLTVPKVQISEVDAPPEGDQ 120
           GLRRPIRLQMQDDNERIRPPPSSSSWHSGCNLGAQGTTLKPLTVPKVQISEVDAPPEGDQ
Sbjct: 61  GLRRPIRLQMQDDNERIRPPPSSSSWHSGCNLGAQGTTLKPLTVPKVQISEVDAPPEGDQ 120

Query: 121 MPSSTDSRGLKPLQEDTPQLMRTRSDVGVRRRGNVRTPSDQRRIRRHRFSINGHFYNHKT 180
           MPSSTDSRGLKPLQEDTPQLMRTRSDVGVRRRGNVRTPSDQRRIRRHRFSINGHFYNHKT
Sbjct: 121 MPSSTDSRGLKPLQEDTPQLMRTRSDVGVRRRGNVRTPSDQRRIRRHRFSINGHFYNHKT 180

Query: 181 SVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQKLKATDY 240
           SVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQKLKATDY
Sbjct: 181 SVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQKLKATDY 240

Query: 241 PLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVKK 300
           PLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVKK
Sbjct: 241 PLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVKK 300

Query: 301 LMRKYTVLRLMIRQRLEEIAETPATI 326
           LMRKYTVLRLMIRQRLEEIAETPATI
Sbjct: 301 LMRKYTVLRLMIRQRLEEIAETPATI 326


>gi|7661964 Ras association domain family 2 [Homo sapiens]
          Length = 326

 Score =  654 bits (1687), Expect = 0.0
 Identities = 326/326 (100%), Positives = 326/326 (100%)

Query: 1   MDYSHQTSLVPCGQDKYISKNELLLHLKTYNLYYEGQNLQLRHREEEDEFIVEGLLNISW 60
           MDYSHQTSLVPCGQDKYISKNELLLHLKTYNLYYEGQNLQLRHREEEDEFIVEGLLNISW
Sbjct: 1   MDYSHQTSLVPCGQDKYISKNELLLHLKTYNLYYEGQNLQLRHREEEDEFIVEGLLNISW 60

Query: 61  GLRRPIRLQMQDDNERIRPPPSSSSWHSGCNLGAQGTTLKPLTVPKVQISEVDAPPEGDQ 120
           GLRRPIRLQMQDDNERIRPPPSSSSWHSGCNLGAQGTTLKPLTVPKVQISEVDAPPEGDQ
Sbjct: 61  GLRRPIRLQMQDDNERIRPPPSSSSWHSGCNLGAQGTTLKPLTVPKVQISEVDAPPEGDQ 120

Query: 121 MPSSTDSRGLKPLQEDTPQLMRTRSDVGVRRRGNVRTPSDQRRIRRHRFSINGHFYNHKT 180
           MPSSTDSRGLKPLQEDTPQLMRTRSDVGVRRRGNVRTPSDQRRIRRHRFSINGHFYNHKT
Sbjct: 121 MPSSTDSRGLKPLQEDTPQLMRTRSDVGVRRRGNVRTPSDQRRIRRHRFSINGHFYNHKT 180

Query: 181 SVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQKLKATDY 240
           SVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQKLKATDY
Sbjct: 181 SVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQKLKATDY 240

Query: 241 PLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVKK 300
           PLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVKK
Sbjct: 241 PLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVKK 300

Query: 301 LMRKYTVLRLMIRQRLEEIAETPATI 326
           LMRKYTVLRLMIRQRLEEIAETPATI
Sbjct: 301 LMRKYTVLRLMIRQRLEEIAETPATI 326


>gi|23510360 Ras association domain family 4 [Homo sapiens]
          Length = 321

 Score =  350 bits (898), Expect = 1e-96
 Identities = 188/330 (56%), Positives = 232/330 (70%), Gaps = 33/330 (10%)

Query: 7   TSLVPCGQDKYISKNELLLHLKTYNLYYEGQNLQLRHREEEDEFIVEGLLNISWGLRRPI 66
           +S VP    K I K+ELL  LKTYN Y+EG++ QLRHREEE   I+EGLLNI+WGLRRPI
Sbjct: 8   SSHVPISDSKSIQKSELLGLLKTYNCYHEGKSFQLRHREEEGTLIIEGLLNIAWGLRRPI 67

Query: 67  RLQMQDDNERIRPPPSSSSW---HSGC----------NLGAQGTTLKPLTVPKVQISEVD 113
           RLQMQDD E++  P  S+SW      C          N+ AQG +++P+           
Sbjct: 68  RLQMQDDREQVHLP--STSWMPRRPSCPLKEPSPQNGNITAQGPSIQPV----------- 114

Query: 114 APPEGDQMPSSTDSRGLKPLQEDTPQLMRTRSDVGV--RRRGNVRTPSDQRRIRRHRFSI 171
                 +  SSTDS G     E+ PQLMRT+SD     +RR   R P + +RIRRHRFSI
Sbjct: 115 -----HKAESSTDSSGPLEEAEEAPQLMRTKSDASCMSQRRPKCRAPGEAQRIRRHRFSI 169

Query: 172 NGHFYNHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGE 231
           NGHFYNHKTSVFTPAYGSVTNVR+NSTMTT QVL LLLNKF++E+   EFALY+VH SGE
Sbjct: 170 NGHFYNHKTSVFTPAYGSVTNVRVNSTMTTLQVLTLLLNKFRVEDGPSEFALYIVHESGE 229

Query: 232 KQKLKATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQ 291
           + KLK  +YPLI+RIL GPCE+I+++FLME D   EV ++VAQYIKFEMPVL SF++KL+
Sbjct: 230 RTKLKDCEYPLISRILHGPCEKIARIFLMEADLGVEVPHEVAQYIKFEMPVLDSFVEKLK 289

Query: 292 EEEDREVKKLMRKYTVLRLMIRQRLEEIAE 321
           EEE+RE+ KL  K+  LRL + QRLE++ E
Sbjct: 290 EEEEREIIKLTMKFQALRLTMLQRLEQLVE 319


>gi|41393610 Ras association (RalGDS/AF-6) domain family 6 isoform b
           [Homo sapiens]
          Length = 369

 Score =  229 bits (585), Expect = 2e-60
 Identities = 136/338 (40%), Positives = 215/338 (63%), Gaps = 20/338 (5%)

Query: 4   SHQ-TSLVPCGQDKYISKNELLLHLKTYNLYYEGQ-NLQLRHREEED-EFIVEGLLNISW 60
           +HQ  S +   +  +I++ +L   LKTYN++YE Q NL + + E ED + IVEG+L+I W
Sbjct: 37  AHQYPSWIFINEKTFITREQLNSLLKTYNIFYENQKNLHILYGETEDGKLIVEGMLDIFW 96

Query: 61  GLRRPIRLQMQDDNERIRPPPSSSSWHSGCNLGAQGTTLKPLTVPKVQISEVDAP--PEG 118
           G++RPI+L++QD+    +P  S +S  S     ++G T         +ISE+D    P  
Sbjct: 97  GVKRPIQLKIQDE----KPFSSFTSMKSSDVFSSKGMTRWGEFDDLYRISELDRTQIPMS 152

Query: 119 DQMPSSTD-----SRGLKPL---QEDTPQLMRTRSDVGVRRRGNVRTPSDQRRIRRHRFS 170
           ++  S  D     S  LKP    + D+P L RT S+  + R+       D++  +++R S
Sbjct: 153 EKRNSQEDYLSYHSNTLKPHAKDEPDSPVLYRTMSEAALVRKRMKPLMMDRKERQKNRAS 212

Query: 171 INGHFYNHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSG 230
           INGHFYNH+TS+F PA+ S T VR+NS M T +V+K LL KFKIENS ++FAL+++  +G
Sbjct: 213 INGHFYNHETSIFIPAFESETKVRVNSNMRTEEVIKQLLQKFKIENSPQDFALHIIFATG 272

Query: 231 EKQKLKATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKL 290
           E+++LK TD PL+ R+LQGP E+ +++FLM+KD  EE++ DVAQYI F   +L+S +Q+L
Sbjct: 273 EQRRLKKTDIPLLQRLLQGPSEKNARIFLMDKD-AEEISSDVAQYINFHFSLLESILQRL 331

Query: 291 QEEEDREVKKLMRKYTVLRLMIRQRLEE--IAETPATI 326
            EEE RE+++++ K+   + +I + L+   + +T  T+
Sbjct: 332 NEEEKREIQRIVTKFNKEKAIILKCLQNKLVIKTETTV 369


>gi|29789443 Ras association (RalGDS/AF-6) domain family 6 isoform a
           [Homo sapiens]
          Length = 337

 Score =  229 bits (585), Expect = 2e-60
 Identities = 136/338 (40%), Positives = 215/338 (63%), Gaps = 20/338 (5%)

Query: 4   SHQ-TSLVPCGQDKYISKNELLLHLKTYNLYYEGQ-NLQLRHREEED-EFIVEGLLNISW 60
           +HQ  S +   +  +I++ +L   LKTYN++YE Q NL + + E ED + IVEG+L+I W
Sbjct: 5   AHQYPSWIFINEKTFITREQLNSLLKTYNIFYENQKNLHILYGETEDGKLIVEGMLDIFW 64

Query: 61  GLRRPIRLQMQDDNERIRPPPSSSSWHSGCNLGAQGTTLKPLTVPKVQISEVDAP--PEG 118
           G++RPI+L++QD+    +P  S +S  S     ++G T         +ISE+D    P  
Sbjct: 65  GVKRPIQLKIQDE----KPFSSFTSMKSSDVFSSKGMTRWGEFDDLYRISELDRTQIPMS 120

Query: 119 DQMPSSTD-----SRGLKPL---QEDTPQLMRTRSDVGVRRRGNVRTPSDQRRIRRHRFS 170
           ++  S  D     S  LKP    + D+P L RT S+  + R+       D++  +++R S
Sbjct: 121 EKRNSQEDYLSYHSNTLKPHAKDEPDSPVLYRTMSEAALVRKRMKPLMMDRKERQKNRAS 180

Query: 171 INGHFYNHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSG 230
           INGHFYNH+TS+F PA+ S T VR+NS M T +V+K LL KFKIENS ++FAL+++  +G
Sbjct: 181 INGHFYNHETSIFIPAFESETKVRVNSNMRTEEVIKQLLQKFKIENSPQDFALHIIFATG 240

Query: 231 EKQKLKATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKL 290
           E+++LK TD PL+ R+LQGP E+ +++FLM+KD  EE++ DVAQYI F   +L+S +Q+L
Sbjct: 241 EQRRLKKTDIPLLQRLLQGPSEKNARIFLMDKD-AEEISSDVAQYINFHFSLLESILQRL 299

Query: 291 QEEEDREVKKLMRKYTVLRLMIRQRLEE--IAETPATI 326
            EEE RE+++++ K+   + +I + L+   + +T  T+
Sbjct: 300 NEEEKREIQRIVTKFNKEKAIILKCLQNKLVIKTETTV 337


>gi|32996735 Ras association (RalGDS/AF-6) domain family 5 isoform C
           [Homo sapiens]
          Length = 265

 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 44/148 (29%), Positives = 85/148 (57%), Gaps = 10/148 (6%)

Query: 179 KTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYV-VHTSGEK--QKL 235
           +TS + P   ++  + I+ST T  +V++ LL KF + ++ ++FAL+  +H  G+   QKL
Sbjct: 124 RTSFYLPL-DAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKL 182

Query: 236 KATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEED 295
              D PL  R+L GP  ++   F++++++  EV +D      F +P L++F+  L++EE 
Sbjct: 183 SIADRPLYLRLLAGPDTEVLS-FVLKENETGEVEWDA-----FSIPELQNFLTILEKEEQ 236

Query: 296 REVKKLMRKYTVLRLMIRQRLEEIAETP 323
            +++++ +KY   R  + + L E    P
Sbjct: 237 DKIQQVQKKYDKFRQKLEEALRESQGKP 264


>gi|32996731 Ras association (RalGDS/AF-6) domain family 5 isoform A
           [Homo sapiens]
          Length = 418

 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 44/148 (29%), Positives = 85/148 (57%), Gaps = 10/148 (6%)

Query: 179 KTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYV-VHTSGEK--QKL 235
           +TS + P   ++  + I+ST T  +V++ LL KF + ++ ++FAL+  +H  G+   QKL
Sbjct: 277 RTSFYLPL-DAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKL 335

Query: 236 KATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEED 295
              D PL  R+L GP  ++   F++++++  EV +D      F +P L++F+  L++EE 
Sbjct: 336 SIADRPLYLRLLAGPDTEVLS-FVLKENETGEVEWDA-----FSIPELQNFLTILEKEEQ 389

Query: 296 REVKKLMRKYTVLRLMIRQRLEEIAETP 323
            +++++ +KY   R  + + L E    P
Sbjct: 390 DKIQQVQKKYDKFRQKLEEALRESQGKP 417


>gi|30039698 Ras association (RalGDS/AF-6) domain family member 3
           [Homo sapiens]
          Length = 238

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 40/135 (29%), Positives = 71/135 (52%), Gaps = 11/135 (8%)

Query: 188 GSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYV-VHTSGEKQKLKATD--YPLIA 244
           G +  + I+ST T  +V++ LL KF +  S  +FALY   H   +    K +D  +PL  
Sbjct: 108 GCMNTLHISSTNTVGEVIEALLKKFLVTESPAKFALYKRCHREDQVYACKLSDREHPLYL 167

Query: 245 RILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVKKLMRK 304
           R++ GP        L E        +++ ++  F +P L++F++ L +EED +++ L R+
Sbjct: 168 RLVAGPRTDTLSFVLRE--------HEIGEWEAFSLPELQNFLRILDKEEDEQLQNLKRR 219

Query: 305 YTVLRLMIRQRLEEI 319
           YT  R  + + L E+
Sbjct: 220 YTAYRQKLEEALREV 234


>gi|25777684 Ras association domain family 1 isoform D [Homo
           sapiens]
          Length = 344

 Score = 61.6 bits (148), Expect = 9e-10
 Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 10/147 (6%)

Query: 173 GHFYNHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVV---HTS 229
           G     +TS + P   +V ++ + S     +V++ LL KF + +   +FAL+     H  
Sbjct: 199 GTSVRRRTSFYLPK-DAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQ 257

Query: 230 GEKQKLKATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQK 289
              +KL   + PL  R+L GP ++     L E D   EV +D      F MP L +F++ 
Sbjct: 258 VYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDS-GEVNWDA-----FSMPELHNFLRI 311

Query: 290 LQEEEDREVKKLMRKYTVLRLMIRQRL 316
           LQ EE+  ++++++KY+  R  I++ L
Sbjct: 312 LQREEEEHLRQILQKYSYCRQKIQEAL 338


>gi|25777682 Ras association domain family 1 isoform C [Homo
           sapiens]
          Length = 270

 Score = 61.6 bits (148), Expect = 9e-10
 Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 10/147 (6%)

Query: 173 GHFYNHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVV---HTS 229
           G     +TS + P   +V ++ + S     +V++ LL KF + +   +FAL+     H  
Sbjct: 125 GTSVRRRTSFYLPK-DAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQ 183

Query: 230 GEKQKLKATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQK 289
              +KL   + PL  R+L GP ++     L E D   EV +D      F MP L +F++ 
Sbjct: 184 VYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDS-GEVNWDA-----FSMPELHNFLRI 237

Query: 290 LQEEEDREVKKLMRKYTVLRLMIRQRL 316
           LQ EE+  ++++++KY+  R  I++ L
Sbjct: 238 LQREEEEHLRQILQKYSYCRQKIQEAL 264


>gi|20149588 Ras association domain family 1 isoform A [Homo
           sapiens]
          Length = 340

 Score = 61.6 bits (148), Expect = 9e-10
 Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 10/147 (6%)

Query: 173 GHFYNHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVV---HTS 229
           G     +TS + P   +V ++ + S     +V++ LL KF + +   +FAL+     H  
Sbjct: 195 GTSVRRRTSFYLPK-DAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQ 253

Query: 230 GEKQKLKATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQK 289
              +KL   + PL  R+L GP ++     L E D   EV +D      F MP L +F++ 
Sbjct: 254 VYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDS-GEVNWDA-----FSMPELHNFLRI 307

Query: 290 LQEEEDREVKKLMRKYTVLRLMIRQRL 316
           LQ EE+  ++++++KY+  R  I++ L
Sbjct: 308 LQREEEEHLRQILQKYSYCRQKIQEAL 334


>gi|25777680 Ras association domain family 1 isoform B [Homo
           sapiens]
          Length = 189

 Score = 61.6 bits (148), Expect = 9e-10
 Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 10/147 (6%)

Query: 173 GHFYNHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVV---HTS 229
           G     +TS + P   +V ++ + S     +V++ LL KF + +   +FAL+     H  
Sbjct: 44  GTSVRRRTSFYLPK-DAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQ 102

Query: 230 GEKQKLKATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQK 289
              +KL   + PL  R+L GP ++     L E D   EV +D      F MP L +F++ 
Sbjct: 103 VYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDS-GEVNWDA-----FSMPELHNFLRI 156

Query: 290 LQEEEDREVKKLMRKYTVLRLMIRQRL 316
           LQ EE+  ++++++KY+  R  I++ L
Sbjct: 157 LQREEEEHLRQILQKYSYCRQKIQEAL 183


>gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 4 isoform 1 [Homo
           sapiens]
          Length = 1834

 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 30/112 (26%), Positives = 60/112 (53%), Gaps = 5/112 (4%)

Query: 193 VRINSTMTTPQVLKLLLNKFKIEN---SAEEFALYVVHTSGEKQKLKATDYPLIARILQG 249
           +R++ST TT  V++ L  KF+ +    S+ +++LY VH SGE+ +L   + PL+ ++   
Sbjct: 60  IRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGER-RLDIDEKPLVVQLNWN 118

Query: 250 PCEQISKVFLM-EKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVKK 300
             ++  +  L  E D +           + +  V+++F + L ++E +E KK
Sbjct: 119 KDDREGRFVLKNENDAIPPKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKK 170


>gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 4 isoform 3 [Homo
           sapiens]
          Length = 1612

 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 30/112 (26%), Positives = 60/112 (53%), Gaps = 5/112 (4%)

Query: 193 VRINSTMTTPQVLKLLLNKFKIEN---SAEEFALYVVHTSGEKQKLKATDYPLIARILQG 249
           +R++ST TT  V++ L  KF+ +    S+ +++LY VH SGE+ +L   + PL+ ++   
Sbjct: 60  IRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGER-RLDIDEKPLVVQLNWN 118

Query: 250 PCEQISKVFLM-EKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVKK 300
             ++  +  L  E D +           + +  V+++F + L ++E +E KK
Sbjct: 119 KDDREGRFVLKNENDAIPPKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKK 170


>gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 4 isoform 2 [Homo
           sapiens]
          Length = 1651

 Score = 41.2 bits (95), Expect = 0.001
 Identities = 32/115 (27%), Positives = 63/115 (54%), Gaps = 10/115 (8%)

Query: 193 VRINSTMTTPQVLKLLLNKFKIEN---SAEEFALYVVHTSGEKQKLKATDYPLIARILQG 249
           +R++ST TT  V++ L  KF+ +    S+ +++LY VH SGE+ +L   + PL+ ++   
Sbjct: 60  IRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGER-RLDIDEKPLVVQLNWN 118

Query: 250 PCEQISKVFLMEKDQVEEVTYDVAQYIKFEMP----VLKSFIQKLQEEEDREVKK 300
             ++  +  L  K++ + +    AQ    E      V+++F + L ++E +E KK
Sbjct: 119 KDDREGRFVL--KNENDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKK 171


>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
           sapiens]
          Length = 730

 Score = 38.1 bits (87), Expect = 0.011
 Identities = 32/136 (23%), Positives = 64/136 (47%), Gaps = 18/136 (13%)

Query: 139 QLMRTRSDVGVRRRGNVRTPSDQRRIRR--HRFSINGHFYNHKTSV------FTPAY--- 187
           +L   +  +G+ RR  V   S Q++ +   H+FS+  ++  H+ +V      F   Y   
Sbjct: 342 ELKEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITE 401

Query: 188 GSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQKLKATDYPLIARIL 247
            S  +V+   +    ++LK++  K  I+ + E+ AL  +  SGEK +L+  D      ++
Sbjct: 402 HSYVSVKAKVSSIAQEILKVVAEK--IQYAEEDLALVAITFSGEKHELQPNDL-----VI 454

Query: 248 QGPCEQISKVFLMEKD 263
               E   ++++  KD
Sbjct: 455 SKSLEASGRIYVYRKD 470


>gi|32996733 Ras association (RalGDS/AF-6) domain family 5 isoform B
           [Homo sapiens]
          Length = 336

 Score = 33.5 bits (75), Expect = 0.26
 Identities = 17/54 (31%), Positives = 34/54 (62%), Gaps = 2/54 (3%)

Query: 179 KTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYV-VHTSGE 231
           +TS + P   ++  + I+ST T  +V++ LL KF + ++ ++FAL+  +H  G+
Sbjct: 277 RTSFYLPL-DAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQ 329


>gi|205277394 coenzyme A synthase isoform c [Homo sapiens]
          Length = 593

 Score = 33.1 bits (74), Expect = 0.34
 Identities = 16/56 (28%), Positives = 32/56 (57%), Gaps = 9/56 (16%)

Query: 207 LLLNKFKIENSAEEFALYVV-------HTSGEKQKLKATDY--PLIARILQGPCEQ 253
           + +N+F++EN  EE ALY +       HT  E+ K+ ++ +   ++  +L+ P E+
Sbjct: 325 MAINRFRLENDLEELALYQIQLLKDLRHTENEEDKVSSSSFRQRMLGNLLRPPYER 380


>gi|110227607 coenzyme A synthase isoform b [Homo sapiens]
          Length = 269

 Score = 33.1 bits (74), Expect = 0.34
 Identities = 16/56 (28%), Positives = 32/56 (57%), Gaps = 9/56 (16%)

Query: 207 LLLNKFKIENSAEEFALYVV-------HTSGEKQKLKATDY--PLIARILQGPCEQ 253
           + +N+F++EN  EE ALY +       HT  E+ K+ ++ +   ++  +L+ P E+
Sbjct: 1   MAINRFRLENDLEELALYQIQLLKDLRHTENEEDKVSSSSFRQRMLGNLLRPPYER 56


>gi|110227605 coenzyme A synthase isoform a [Homo sapiens]
          Length = 564

 Score = 33.1 bits (74), Expect = 0.34
 Identities = 16/56 (28%), Positives = 32/56 (57%), Gaps = 9/56 (16%)

Query: 207 LLLNKFKIENSAEEFALYVV-------HTSGEKQKLKATDY--PLIARILQGPCEQ 253
           + +N+F++EN  EE ALY +       HT  E+ K+ ++ +   ++  +L+ P E+
Sbjct: 296 MAINRFRLENDLEELALYQIQLLKDLRHTENEEDKVSSSSFRQRMLGNLLRPPYER 351


>gi|110227601 coenzyme A synthase isoform a [Homo sapiens]
          Length = 564

 Score = 33.1 bits (74), Expect = 0.34
 Identities = 16/56 (28%), Positives = 32/56 (57%), Gaps = 9/56 (16%)

Query: 207 LLLNKFKIENSAEEFALYVV-------HTSGEKQKLKATDY--PLIARILQGPCEQ 253
           + +N+F++EN  EE ALY +       HT  E+ K+ ++ +   ++  +L+ P E+
Sbjct: 296 MAINRFRLENDLEELALYQIQLLKDLRHTENEEDKVSSSSFRQRMLGNLLRPPYER 351


>gi|110227603 coenzyme A synthase isoform a [Homo sapiens]
          Length = 564

 Score = 33.1 bits (74), Expect = 0.34
 Identities = 16/56 (28%), Positives = 32/56 (57%), Gaps = 9/56 (16%)

Query: 207 LLLNKFKIENSAEEFALYVV-------HTSGEKQKLKATDY--PLIARILQGPCEQ 253
           + +N+F++EN  EE ALY +       HT  E+ K+ ++ +   ++  +L+ P E+
Sbjct: 296 MAINRFRLENDLEELALYQIQLLKDLRHTENEEDKVSSSSFRQRMLGNLLRPPYER 351


>gi|21361440 RAB3A interacting protein (rabin3)-like 1 [Homo
           sapiens]
          Length = 382

 Score = 32.7 bits (73), Expect = 0.45
 Identities = 29/125 (23%), Positives = 58/125 (46%), Gaps = 20/125 (16%)

Query: 204 VLKLLLNKFKIENSAEEFALYVVHTSGEKQKLKATDYPLIARILQGPCEQISKVFLMEKD 263
           VL+L  +  +I     EF    +H + ++ KLK  +           CE++SKV    + 
Sbjct: 61  VLRLRSSSMEIREKGSEFLKEELHRAQKELKLKDEE-----------CERLSKVREQLEQ 109

Query: 264 QVEEVT---YDVAQYIKFEMPVLKSFIQKLQEEEDREVKKLMRKYTVLRLMIRQRLEEIA 320
           ++EE+T   ++ A  +  E  + ++  +K  +E   ++  L  + T L+ ++      I 
Sbjct: 110 ELEELTASLFEEAHKMVREANMKQAASEKQLKEARGKIDMLQAEVTALKTLV------IT 163

Query: 321 ETPAT 325
            TPA+
Sbjct: 164 STPAS 168


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 31.6 bits (70), Expect = 1.0
 Identities = 29/107 (27%), Positives = 42/107 (39%), Gaps = 10/107 (9%)

Query: 63   RRPIRLQMQDDNERIRPPPSSSSWHSGCNLGAQGTTLKPLT-VPKVQISEVDAPPEGDQM 121
            R P R      +  +R    + S HS   L      +K +   P    SE D+ PE   +
Sbjct: 1433 RTPSRRSRSGSSPGLRDGSGTPSRHS---LSGSSPGMKDIPRTPSRGRSECDSSPEPKAL 1489

Query: 122  PSSTDSRGLKPLQED------TPQLMRTRSDVGVRRRGNVRTPSDQR 162
            P +   R   P   +      TPQ  R+ S+  V ++   RTP  QR
Sbjct: 1490 PQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQR 1536


>gi|148277037 AP2 associated kinase 1 [Homo sapiens]
          Length = 961

 Score = 31.2 bits (69), Expect = 1.3
 Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 6/68 (8%)

Query: 77  IRPPPSSSSWHSGCNLGAQGTTLKPLT-----VPKVQISEVDAPPEGDQMPSSTDSRGLK 131
           ++PPP ++   +   L A     KP       +P+ Q  +  APP   Q P ST ++GL 
Sbjct: 396 VQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTP-STQAQGLP 454

Query: 132 PLQEDTPQ 139
              + TPQ
Sbjct: 455 AQAQATPQ 462


>gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens]
          Length = 1711

 Score = 31.2 bits (69), Expect = 1.3
 Identities = 24/68 (35%), Positives = 31/68 (45%), Gaps = 7/68 (10%)

Query: 80  PPSSSSWHSGCNLGAQGT--TLKPLTVPKVQISEVDAPPEGDQMP---SSTDSRGLKPL- 133
           PP  +   SG     +GT  T  PL  P     E+ +PPE  +MP   SS  +R   PL 
Sbjct: 577 PPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLEREMASPPECSEMPLDLSSKSNRQKLPLP 636

Query: 134 -QEDTPQL 140
            Q  TP +
Sbjct: 637 NQRKTPPM 644


>gi|148596992 heart alpha-kinase [Homo sapiens]
          Length = 2170

 Score = 31.2 bits (69), Expect = 1.3
 Identities = 19/66 (28%), Positives = 35/66 (53%), Gaps = 6/66 (9%)

Query: 188  GSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQKLKATDYPLIARIL 247
            G+VT+  I+  M  P++  L + + K  +S+   A  +   SGE++  KA       ++L
Sbjct: 1616 GNVTDFLISHKMEEPKIEVLQIGETKPPSSSSSSAKTLAFISGERELEKA------PKLL 1669

Query: 248  QGPCEQ 253
            Q PC++
Sbjct: 1670 QDPCQK 1675


>gi|50083293 coiled-coil domain containing 123 [Homo sapiens]
          Length = 783

 Score = 31.2 bits (69), Expect = 1.3
 Identities = 27/106 (25%), Positives = 52/106 (49%), Gaps = 11/106 (10%)

Query: 213 KIENSAEEFALYVVHTSGEKQKLKATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDV 272
           ++    ++  L    T G++++L      L   IL+  C+++      +     ++  +V
Sbjct: 461 EVSKLTKQLMLLEAKTHGQEKELAENREQL--EILRAKCQEL------KTHSDGKIAVEV 512

Query: 273 AQYIKFEMPVLKSFIQKLQEEEDREVKKLMRKYTVLRLMIRQRLEE 318
            + I  E   LKS +QK +E+E  E+++LM K TVL+   +  L E
Sbjct: 513 HKSIVNE---LKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLE 555


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score = 30.8 bits (68), Expect = 1.7
 Identities = 33/128 (25%), Positives = 58/128 (45%), Gaps = 21/128 (16%)

Query: 195 INSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQKLKATDYPLIARILQGPCEQI 254
           +N  +   QV KL + K ++    +E    V   S EK          +  +LQ   E +
Sbjct: 741 LNKLLENEQVQKLFV-KTQLYGFLKEMGSEVSEDSEEKD---------VVNVLQAVGESL 790

Query: 255 SKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEE---EDREVKKLMRKYTVLRLM 311
           +K+         E   ++A     ++  L+  I+ LQEE   +  E+K L+R Y   +++
Sbjct: 791 AKI--------NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVL 842

Query: 312 IRQRLEEI 319
           +R+ LEEI
Sbjct: 843 LRKELEEI 850


>gi|157785668 coiled-coil domain containing 39 [Homo sapiens]
          Length = 941

 Score = 30.4 bits (67), Expect = 2.2
 Identities = 20/69 (28%), Positives = 39/69 (56%), Gaps = 1/69 (1%)

Query: 253 QISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVKKLMRKYTVLRLMI 312
           Q+SK    +K ++E VT   A+  K E+ +LK    +  EE+D +++++ + + V+  M+
Sbjct: 784 QLSKETEEQKPKLERVTKQCAKLTK-EIRLLKDTKDETMEEQDIKLREMKQFHKVIDEML 842

Query: 313 RQRLEEIAE 321
              +EE  E
Sbjct: 843 VDIIEENTE 851


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,884,431
Number of Sequences: 37866
Number of extensions: 606253
Number of successful extensions: 2135
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 2075
Number of HSP's gapped (non-prelim): 85
length of query: 326
length of database: 18,247,518
effective HSP length: 103
effective length of query: 223
effective length of database: 14,347,320
effective search space: 3199452360
effective search space used: 3199452360
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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