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Search of human proteins with 25188199
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25188199 leucine carboxyl methyltransferase 2 [Homo sapiens]
(686 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25188199 leucine carboxyl methyltransferase 2 [Homo sapiens] 1399 0.0
gi|74048434 leucine carboxyl methyltransferase 1 isoform a [Homo... 179 1e-44
gi|74048545 leucine carboxyl methyltransferase 1 isoform b [Homo... 129 1e-29
gi|16945972 kelch domain containing 3 [Homo sapiens] 46 1e-04
gi|46410931 attractin-like 1 [Homo sapiens] 40 0.009
gi|55956890 kelch/ankyrin repeat containing cyclin A1 interactin... 40 0.009
gi|55956888 kelch/ankyrin repeat containing cyclin A1 interactin... 40 0.009
gi|98986457 host cell factor 1 [Homo sapiens] 39 0.021
gi|145701025 multiple EGF-like-domains 8 [Homo sapiens] 39 0.021
gi|7019405 host cell factor C2 [Homo sapiens] 39 0.021
gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens] 39 0.021
gi|7657301 kelch domain containing 2 [Homo sapiens] 36 0.10
gi|44917619 kelch domain containing 10 [Homo sapiens] 34 0.39
gi|226442729 kelch-like 15 [Homo sapiens] 32 2.0
gi|158508542 kelch-like 33 [Homo sapiens] 32 2.6
gi|47717139 leucine-zipper-like transcription regulator 1 [Homo ... 31 3.3
gi|8922528 kelch-like 11 [Homo sapiens] 31 3.3
gi|214831495 hypothetical protein LOC285679 [Homo sapiens] 31 4.4
gi|55741643 kelch-like 14 [Homo sapiens] 31 4.4
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso... 30 7.4
gi|8922640 kelch domain containing 8A [Homo sapiens] 30 7.4
gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] 30 9.7
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 30 9.7
>gi|25188199 leucine carboxyl methyltransferase 2 [Homo sapiens]
Length = 686
Score = 1399 bits (3620), Expect = 0.0
Identities = 686/686 (100%), Positives = 686/686 (100%)
Query: 1 MGPRSRERRAGAVQNTNDSSALSKRSLAARGYVQDPFAALLVPGAARRAPLIHRGYYVRA 60
MGPRSRERRAGAVQNTNDSSALSKRSLAARGYVQDPFAALLVPGAARRAPLIHRGYYVRA
Sbjct: 1 MGPRSRERRAGAVQNTNDSSALSKRSLAARGYVQDPFAALLVPGAARRAPLIHRGYYVRA 60
Query: 61 RAVRHCVRAFLEQIGAPQAALRAQILSLGAGFDSLYFRLKTAGRLARAAVWEVDFPDVAR 120
RAVRHCVRAFLEQIGAPQAALRAQILSLGAGFDSLYFRLKTAGRLARAAVWEVDFPDVAR
Sbjct: 61 RAVRHCVRAFLEQIGAPQAALRAQILSLGAGFDSLYFRLKTAGRLARAAVWEVDFPDVAR 120
Query: 121 RKAERIGETPELCALTGPFERGEPASALCFESADYCILGLDLRQLQRVEEALGAAGLDAA 180
RKAERIGETPELCALTGPFERGEPASALCFESADYCILGLDLRQLQRVEEALGAAGLDAA
Sbjct: 121 RKAERIGETPELCALTGPFERGEPASALCFESADYCILGLDLRQLQRVEEALGAAGLDAA 180
Query: 181 SPTLLLAEAVLTYLEPESAAALIAWAAQRFPNALFVVYEQMRPQDAFGQFMLQHFRQLNS 240
SPTLLLAEAVLTYLEPESAAALIAWAAQRFPNALFVVYEQMRPQDAFGQFMLQHFRQLNS
Sbjct: 181 SPTLLLAEAVLTYLEPESAAALIAWAAQRFPNALFVVYEQMRPQDAFGQFMLQHFRQLNS 240
Query: 241 PLHGLERFPDVEAQRRRFLQAGWTACGAVDMNEFYHCFLPAEERRRVENIEPFDEFEEWH 300
PLHGLERFPDVEAQRRRFLQAGWTACGAVDMNEFYHCFLPAEERRRVENIEPFDEFEEWH
Sbjct: 241 PLHGLERFPDVEAQRRRFLQAGWTACGAVDMNEFYHCFLPAEERRRVENIEPFDEFEEWH 300
Query: 301 LKCAHYFILAASRGDTLSHTLVFPSSEAFPRVNPASPSGVFPASVVSSEGQVPNLKRYGH 360
LKCAHYFILAASRGDTLSHTLVFPSSEAFPRVNPASPSGVFPASVVSSEGQVPNLKRYGH
Sbjct: 301 LKCAHYFILAASRGDTLSHTLVFPSSEAFPRVNPASPSGVFPASVVSSEGQVPNLKRYGH 360
Query: 361 ASVFLSPDVILSAGGFGEQEGRHCRVSQFHLLSRDCDSEWKGSQIGSCGTGVQWDGRLYH 420
ASVFLSPDVILSAGGFGEQEGRHCRVSQFHLLSRDCDSEWKGSQIGSCGTGVQWDGRLYH
Sbjct: 361 ASVFLSPDVILSAGGFGEQEGRHCRVSQFHLLSRDCDSEWKGSQIGSCGTGVQWDGRLYH 420
Query: 421 TMTRLSESRVLVLGGRLSPVSPALGVLQLHFFKSEDNNTEDLKVTITKAGRKDDSTLCCW 480
TMTRLSESRVLVLGGRLSPVSPALGVLQLHFFKSEDNNTEDLKVTITKAGRKDDSTLCCW
Sbjct: 421 TMTRLSESRVLVLGGRLSPVSPALGVLQLHFFKSEDNNTEDLKVTITKAGRKDDSTLCCW 480
Query: 481 RHSTTEVSCQNQEYLFVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPEARHSHSAC 540
RHSTTEVSCQNQEYLFVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPEARHSHSAC
Sbjct: 481 RHSTTEVSCQNQEYLFVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPEARHSHSAC 540
Query: 541 TWQGGALIAGGLGASEEPLNSVLFLRPISCGFLWESVDIQPPITPRYSHTAHVLNGKLLL 600
TWQGGALIAGGLGASEEPLNSVLFLRPISCGFLWESVDIQPPITPRYSHTAHVLNGKLLL
Sbjct: 541 TWQGGALIAGGLGASEEPLNSVLFLRPISCGFLWESVDIQPPITPRYSHTAHVLNGKLLL 600
Query: 601 VGGIWIHSSSFPGVTVINLTTGLSSEYQIDTTYVPWPLMLHNHTSILLPEEQQLLLLGGG 660
VGGIWIHSSSFPGVTVINLTTGLSSEYQIDTTYVPWPLMLHNHTSILLPEEQQLLLLGGG
Sbjct: 601 VGGIWIHSSSFPGVTVINLTTGLSSEYQIDTTYVPWPLMLHNHTSILLPEEQQLLLLGGG 660
Query: 661 GNCFSFGTYFNPHTVTLDLSSLSAGQ 686
GNCFSFGTYFNPHTVTLDLSSLSAGQ
Sbjct: 661 GNCFSFGTYFNPHTVTLDLSSLSAGQ 686
>gi|74048434 leucine carboxyl methyltransferase 1 isoform a [Homo
sapiens]
Length = 334
Score = 179 bits (453), Expect = 1e-44
Identities = 111/305 (36%), Positives = 160/305 (52%), Gaps = 10/305 (3%)
Query: 13 VQNTNDSSALSKRSLAARGYVQDPFAALLVP-GAARRAPLIHRGYYVRARAVRHCVRAFL 71
V+ T + ++L KR + GY DP+ V R+AP I+RGY+ R V ++AFL
Sbjct: 26 VRGTCEDASLCKRFAVSIGYWHDPYIQHFVRLSKERKAPEINRGYFARVHGVSQLIKAFL 85
Query: 72 EQIGAPQAALRAQILSLGAGFDSLYFRLKTAGRLARAAVWEVDFPDVARRKAERIGETPE 131
+ QI++LGAG D+ ++RLK L + +EVDFP + RK I P
Sbjct: 86 RK-----TECHCQIVNLGAGMDTTFWRLKDEDLLP-SKYFEVDFPMIVTRKLHSIKCKPP 139
Query: 132 LCA--LTGPFERGEPASALCFESADYCILGLDLRQLQRVEEALGAAGLDAASPTLLLAEA 189
L + L E +S Y ++G DLR L +EE L ++ PTLL+AE
Sbjct: 140 LSSPILELHSEDTLQMDGHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLPTLLIAEC 199
Query: 190 VLTYLEPESAAALIAWAAQRFPNALFVVYEQMRPQDAFGQFMLQHFRQLNSPLHGLERFP 249
VL Y+ PE +A L+ WAA F A+F+ YEQ+ D FGQ M+++ R+ L G+E
Sbjct: 200 VLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCK 259
Query: 250 DVEAQRRRFLQAGWTACGAVDMNEFYHCFLPAEERRRVENIEPFDEFEEWHLKCAHYFIL 309
+E+Q+ R L GW AVDM E Y+ LP E R+E++E DE E HY +
Sbjct: 260 SLESQKERLLSNGWETASAVDMMELYN-RLPRAEVSRIESLEFLDEMELLEQLMRHYCLC 318
Query: 310 AASRG 314
A++G
Sbjct: 319 WATKG 323
>gi|74048545 leucine carboxyl methyltransferase 1 isoform b [Homo
sapiens]
Length = 279
Score = 129 bits (323), Expect = 1e-29
Identities = 93/303 (30%), Positives = 135/303 (44%), Gaps = 61/303 (20%)
Query: 13 VQNTNDSSALSKRSLAARGYVQDPFAALLVP-GAARRAPLIHRGYYVRARAVRHCVRAFL 71
V+ T + ++L KR + GY DP+ V R+AP I+RGY+ R V ++AFL
Sbjct: 26 VRGTCEDASLCKRFAVSIGYWHDPYIQHFVRLSKERKAPEINRGYFARVHGVSQLIKAFL 85
Query: 72 EQIGAPQAALRAQILSLGAGFDSLYFRLKTAGRLARAAVWEVDFPDVARRKAERIGETPE 131
+ QI++LGAG D+ ++RLK L + +EVDFP + RK I
Sbjct: 86 R-----KTECHCQIVNLGAGMDTTFWRLKDED-LLPSKYFEVDFPMIVTRKLHSIKLPTL 139
Query: 132 LCALTGPFERGEPASALCFESADYCILGLDLRQLQRVEEALGAAGLDAASPTLLLAEAVL 191
L A C+L
Sbjct: 140 LIA--------------------ECVL--------------------------------- 146
Query: 192 TYLEPESAAALIAWAAQRFPNALFVVYEQMRPQDAFGQFMLQHFRQLNSPLHGLERFPDV 251
Y+ PE +A L+ WAA F A+F+ YEQ+ D FGQ M+++ R+ L G+E +
Sbjct: 147 VYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSL 206
Query: 252 EAQRRRFLQAGWTACGAVDMNEFYHCFLPAEERRRVENIEPFDEFEEWHLKCAHYFILAA 311
E+Q+ R L GW AVDM E Y+ LP E R+E++E DE E HY + A
Sbjct: 207 ESQKERLLSNGWETASAVDMMELYN-RLPRAEVSRIESLEFLDEMELLEQLMRHYCLCWA 265
Query: 312 SRG 314
++G
Sbjct: 266 TKG 268
>gi|16945972 kelch domain containing 3 [Homo sapiens]
Length = 382
Score = 45.8 bits (107), Expect = 1e-04
Identities = 65/273 (23%), Positives = 109/273 (39%), Gaps = 41/273 (15%)
Query: 344 SVVSSEGQVPNLKRYGHASVFLSPDVILSAGGFGEQEGRHCRVSQFHLLSRDCDS-EWKG 402
S + + V RYGH++V + D +L GG + EG C V L + D ++ +W
Sbjct: 64 SAIRGQAPVVPYMRYGHSTVLID-DTVLLWGGRNDTEGA-CNV----LYAFDVNTHKWFT 117
Query: 403 SQIGSCGTGVQWDGRLYHTMTRLSESRVLVLGGRLSPVSPALGVLQLHFFKSEDNNTEDL 462
++ G + DG + ++ + + GG Q F ++ + +
Sbjct: 118 PRVSGTVPGAR-DGHSACVLGKI----MYIFGGYEQ---------QADCFSNDIHKLDTS 163
Query: 463 KVTITKAGRKDDSTLCCWR--HSTTEVSCQNQEYLFVYGGR--------SVVEPVLSDWH 512
+T T K WR HS T + +++V+GGR S E +
Sbjct: 164 TMTWTLICTKGSPAR--WRDFHSATMLG----SHMYVFGGRADRFGPFHSNNEIYCNRIR 217
Query: 513 FLHVGTMAWVRIPVEGEVPEARHSHSACTWQGGALIAGGLGAS-EEPLNSVLFLRPISCG 571
T AW+ P +PE R SHSA + G I GG A + + P+S
Sbjct: 218 VFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVS-- 275
Query: 572 FLWESVDIQ-PPITPRYSHTAHVLNGKLLLVGG 603
F W+ ++ + PR ++ K++L GG
Sbjct: 276 FTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGG 308
>gi|46410931 attractin-like 1 [Homo sapiens]
Length = 1379
Score = 39.7 bits (91), Expect = 0.009
Identities = 58/266 (21%), Positives = 101/266 (37%), Gaps = 37/266 (13%)
Query: 355 LKRYGHASVFLSPDVILSAGGFGEQEGRHC-RVSQFHLLSRDCDSEWKGSQIGSCGTGVQ 413
L+RYGH+ ++ + G +G + F++ S+ W G G Q
Sbjct: 353 LQRYGHSLALYQENIFMYGGRIETNDGNVTDELWVFNIHSQS----WSTKTPTVLGHGQQ 408
Query: 414 W--DGRLYHTMTRLSESRVLVLGGRLSPVSPALGVLQLHFFKSEDNNTEDLKVTITKAGR 471
+ +G H M S V+++ S + +Q + S + K I + G
Sbjct: 409 YAVEGHSAHIMELDSRDVVMIIIFGYSAIYGYTSSIQEYHISSNTWLVPETKGAIVQGG- 467
Query: 472 KDDSTLCCWRHSTTEVSCQNQEYLFVYGGRSVVEP----VLSDWHFLHVGTMAWVRIPVE 527
+ T V + + ++V+GG + ++ D + V T W +
Sbjct: 468 ----------YGHTSVYDEITKSIYVHGGYKALPGNKYGLVDDLYKYEVNTKTWTILKES 517
Query: 528 GEVPEARHSHSACTWQGGALIAGGLGASEEPLNSVLFLRPISCGFLWESVDIQP-PITP- 585
G AR+ HSA G LI GG ++ L++ + S FL + I P
Sbjct: 518 GF---ARYLHSAVLINGAMLIFGGNTHNDTSLSNGA--KCFSADFLAYDIACDEWKILPK 572
Query: 586 --------RYSHTAHVLNGKLLLVGG 603
R+ H+A V+NG + + GG
Sbjct: 573 PNLHRDVNRFGHSAVVINGSMYIFGG 598
>gi|55956890 kelch/ankyrin repeat containing cyclin A1 interacting
protein isoform b [Homo sapiens]
Length = 288
Score = 39.7 bits (91), Expect = 0.009
Identities = 42/163 (25%), Positives = 67/163 (41%), Gaps = 7/163 (4%)
Query: 521 WVRIPVEGEVPEARHSHSACTWQGGALIAGGL--GASEEPLNSVLFLRPISCGFLWESVD 578
W PV + AR HS +G + GGL G + EP + + P +
Sbjct: 15 WAWRPVARDALLARAFHSCTELRGRFYLVGGLLAGGAREPSSDTVVFDPARGQAVRLGAR 74
Query: 579 IQPPITPRYSHTAHVLNGKLLLVGGIWIHSSSFPGVTVINLTTGLSSEYQIDTTYVPWPL 638
PP R H A ++G+ L V G W S VT ++ G+ + P P
Sbjct: 75 GSPP---RSHHDAAPVDGRWLCVVGGWDGSRRLATVTALDTERGVWEAWTGTPGDCP-PA 130
Query: 639 MLHNHTSILLPEEQQLLLLGGGGNCFSFGTYFNPHTVTLDLSS 681
L +HT + +++L + G G + Y + +T+ LD S+
Sbjct: 131 GLSSHTCTRI-SDRELQVAGREGGIHTQRRYGSIYTLRLDPSA 172
>gi|55956888 kelch/ankyrin repeat containing cyclin A1 interacting
protein isoform a [Homo sapiens]
Length = 349
Score = 39.7 bits (91), Expect = 0.009
Identities = 42/163 (25%), Positives = 67/163 (41%), Gaps = 7/163 (4%)
Query: 521 WVRIPVEGEVPEARHSHSACTWQGGALIAGGL--GASEEPLNSVLFLRPISCGFLWESVD 578
W PV + AR HS +G + GGL G + EP + + P +
Sbjct: 15 WAWRPVARDALLARAFHSCTELRGRFYLVGGLLAGGAREPSSDTVVFDPARGQAVRLGAR 74
Query: 579 IQPPITPRYSHTAHVLNGKLLLVGGIWIHSSSFPGVTVINLTTGLSSEYQIDTTYVPWPL 638
PP R H A ++G+ L V G W S VT ++ G+ + P P
Sbjct: 75 GSPP---RSHHDAAPVDGRWLCVVGGWDGSRRLATVTALDTERGVWEAWTGTPGDCP-PA 130
Query: 639 MLHNHTSILLPEEQQLLLLGGGGNCFSFGTYFNPHTVTLDLSS 681
L +HT + +++L + G G + Y + +T+ LD S+
Sbjct: 131 GLSSHTCTRI-SDRELQVAGREGGIHTQRRYGSIYTLRLDPSA 172
>gi|98986457 host cell factor 1 [Homo sapiens]
Length = 2035
Score = 38.5 bits (88), Expect = 0.021
Identities = 40/190 (21%), Positives = 78/190 (41%), Gaps = 22/190 (11%)
Query: 492 QEYLFVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPEARHSHSACTWQGGALIAGG 551
+E + V+GG + E ++ + H + T W V G++P ++ L+ GG
Sbjct: 42 KELIVVFGGGN--EGIVDELHVYNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGG 99
Query: 552 LGASEEPLNSVLFLRPISCGFLWESVDIQ-----PPITPRYSHTAHVLNGKLLLVGGIWI 606
+ + N + L+ + + W+ + + PP PR H+ ++ K L GG+
Sbjct: 100 MVEYGKYSNDLYELQ--ASRWEWKRLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLAN 157
Query: 607 HSSS--------FPGVTVINLTTGLS-SEYQIDTTYVPWPLMLHNHTSILLPE----EQQ 653
S + ++ L G + I TY P +HT+++ E + +
Sbjct: 158 DSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSK 217
Query: 654 LLLLGGGGNC 663
L++ GG C
Sbjct: 218 LVIYGGMSGC 227
Score = 30.4 bits (67), Expect = 5.7
Identities = 19/57 (33%), Positives = 25/57 (43%), Gaps = 2/57 (3%)
Query: 495 LFVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPEARHSHSACTWQGGALIAGG 551
L +YGG S L D L + T+ W + + G P R HSA T + GG
Sbjct: 218 LVIYGGMSGCR--LGDLWTLDIDTLTWNKPSLSGVAPLPRSLHSATTIGNKMYVFGG 272
>gi|145701025 multiple EGF-like-domains 8 [Homo sapiens]
Length = 2778
Score = 38.5 bits (88), Expect = 0.021
Identities = 37/138 (26%), Positives = 57/138 (41%), Gaps = 8/138 (5%)
Query: 495 LFVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPEARHSHSACTWQGGALIAGGLGA 554
L V+GG+ + L D + W + P ARHSH A W G ++ GG A
Sbjct: 242 LAVFGGQDL-NNALGDLVLYNFSANTWESWDLS-PAPAARHSHVAVAWAGSLVLMGGELA 299
Query: 555 SEEPLNSVLFLRPISCGFLWESVDIQPPITPRYSHTAHVLNGKLLLVGGIWIHSSSFPGV 614
N V P+ G WE + PP + S + LV +W++ S G
Sbjct: 300 DGSLTNDVWAFSPLGRGH-WEL--LAPPASSS-SGPPGLAGHAAALVDDVWLYVSG--GR 353
Query: 615 TVINLTTGLSSEYQIDTT 632
T +L + +++D+T
Sbjct: 354 TPHDLFSSGLFRFRLDST 371
Score = 33.1 bits (74), Expect = 0.88
Identities = 30/102 (29%), Positives = 42/102 (41%), Gaps = 15/102 (14%)
Query: 515 HVGTMAWVRIPVEGEVPEARHSHSACTWQGGALIAGGLGAS----EEPLNSVLFLRPISC 570
HV T R ++G P R H+A ++ GG + E+ +F + C
Sbjct: 431 HVWTTLKGRDGLQG--PRERAFHTASVLGNYMVVYGGNVHTHYQEEKCYEDGIFFYHLGC 488
Query: 571 GFLWESVDIQPPITP---------RYSHTAHVLNGKLLLVGG 603
++ PP TP RYSH A VL G +LLV G
Sbjct: 489 HQWVSGAELAPPGTPEGRAAPPSGRYSHVAAVLGGSVLLVAG 530
>gi|7019405 host cell factor C2 [Homo sapiens]
Length = 792
Score = 38.5 bits (88), Expect = 0.021
Identities = 28/118 (23%), Positives = 50/118 (42%), Gaps = 9/118 (7%)
Query: 492 QEYLFVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPEARHSHSACTWQGGALIAGG 551
+E + ++GG + E + + H + T W V G++P +H L+ GG
Sbjct: 32 RELMIIFGGGN--EGIADELHVYNTATNQWFLPAVRGDIPPGCAAHGFVCDGTRILVFGG 89
Query: 552 LGASEEPLNSVLFLRPISCGFLWESVDIQPPIT-----PRYSHTAHVLNGKLLLVGGI 604
+ N + L+ + +LW+ V PP + PR H+ + K L GG+
Sbjct: 90 MVEYGRYSNELYELQ--ASRWLWKKVKPHPPPSGLPPCPRLGHSFSLYGNKCYLFGGL 145
Score = 31.6 bits (70), Expect = 2.6
Identities = 32/111 (28%), Positives = 50/111 (45%), Gaps = 18/111 (16%)
Query: 508 LSDWHFLHV----GTMAWVRIPVEGEVPEARHSHSA---CTWQGGA----LIAGGLGASE 556
L+D++ L + G + W +G VP R SH+A C G+ + G GA
Sbjct: 160 LNDFYELELQHGSGVVGWSIPVTKGVVPSPRESHTAVIYCKKDSGSPKMYVFGGMCGARL 219
Query: 557 EPLNSVLFLRPISCGFLWESVDIQPPIT-PRYSHTAHVLNGKLLLVGGIWI 606
+ L L L +S W + + + PR HTA V+ K+ + GG W+
Sbjct: 220 DDLWQ-LDLETMS----WSKPETKGTVPLPRSLHTASVIGNKMYIFGG-WV 264
>gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens]
Length = 372
Score = 38.5 bits (88), Expect = 0.021
Identities = 48/200 (24%), Positives = 78/200 (39%), Gaps = 24/200 (12%)
Query: 355 LKRYGHASVFLS--PDVILSAGGFGEQEGRHCRVSQFHLLSRDCDSEWKGSQIGSCGTGV 412
L RY HAS S PD I GG + R+C +L+ + + W ++ T
Sbjct: 84 LPRYEHASFIPSCTPDRIWVFGGANQSGNRNC----LQVLNPETRT-WTTPEV----TSP 134
Query: 413 QWDGRLYHTMTRLSESRVLVLGGRLSPVSPALGVLQLHFFKSEDNNTEDLKVTITKAGRK 472
R +HT + +++ V GG P +LH F + T+T + +
Sbjct: 135 PPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDT-KLHVFDAN---------TLTWSQPE 184
Query: 473 DDSTLCCWRHSTTEVSCQNQEYLFVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPE 532
RH V+ + LF++GG + + D H + + M W ++ G P
Sbjct: 185 TLGNPPSPRHGHVMVAAGTK--LFIHGGLAG-DRFYDDLHCIDISDMKWQKLNPTGAAPA 241
Query: 533 ARHSHSACTWQGGALIAGGL 552
+HSA I GG+
Sbjct: 242 GCAAHSAVAMGKHVYIFGGM 261
>gi|7657301 kelch domain containing 2 [Homo sapiens]
Length = 406
Score = 36.2 bits (82), Expect = 0.10
Identities = 32/112 (28%), Positives = 51/112 (45%), Gaps = 9/112 (8%)
Query: 496 FVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPEARHSHSACTWQGGAL-IAGGLGA 554
FV+GGR + ++D H+L++ T W + +G P R HS L + GG
Sbjct: 231 FVFGGR-YRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTT 289
Query: 555 SEEPLNSVLFLRPISCGFLWESVDIQPPIT--PRYSHTAHVLN-GKLLLVGG 603
++PL+ C E + P T PR HTA + G++++ GG
Sbjct: 290 DKQPLSDAW----TYCISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFGG 337
>gi|44917619 kelch domain containing 10 [Homo sapiens]
Length = 442
Score = 34.3 bits (77), Expect = 0.39
Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 13/125 (10%)
Query: 429 RVLVLGGRLSPVSPALGVLQLHFFKSEDNNTEDLKVTITKAGRKDDSTLCCWRHSTTEVS 488
R+ +LGG S + +L ++H + E N E++ TK K HS ++
Sbjct: 271 RIYILGGGTSWTAYSLN--KIHAYNLETNAWEEIA---TKPHEKIGFPAARRCHSCVQI- 324
Query: 489 CQNQEYLFVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPEARHSHSACTWQGGAL- 547
+ +F+ GG + E +L D L++ T WV++P +PE + H A G +
Sbjct: 325 ---KNDVFICGGYNG-EVILGDIWKLNLQTFQWVKLP--ATMPEPVYFHCAAVTPAGCMY 378
Query: 548 IAGGL 552
I GG+
Sbjct: 379 IHGGV 383
>gi|226442729 kelch-like 15 [Homo sapiens]
Length = 604
Score = 32.0 bits (71), Expect = 2.0
Identities = 17/37 (45%), Positives = 20/37 (54%), Gaps = 2/37 (5%)
Query: 574 WESVDIQPPITPRYSHTAHVLNGKLLLVGGIWIHSSS 610
WE VD P +Y H VLN KL + GGI S+S
Sbjct: 406 WEFVDPYP--VNKYGHEGTVLNNKLFITGGITSSSTS 440
>gi|158508542 kelch-like 33 [Homo sapiens]
Length = 453
Score = 31.6 bits (70), Expect = 2.6
Identities = 19/75 (25%), Positives = 33/75 (44%), Gaps = 3/75 (4%)
Query: 530 VPEARHSHSACTWQGGALIAGGLGASEEPLNSVLFLRPISCGFLWESVDIQPPITPRYSH 589
+P +H+A +G ++GG G + + L S++ P + P PR H
Sbjct: 275 LPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHYDP---KLEKPGTFLSPMGVPRAGH 331
Query: 590 TAHVLNGKLLLVGGI 604
L G+L + GG+
Sbjct: 332 VMAALGGRLYVAGGL 346
Score = 30.8 bits (68), Expect = 4.4
Identities = 28/76 (36%), Positives = 40/76 (52%), Gaps = 11/76 (14%)
Query: 530 VPEARHSHSACTWQGGAL-IAGGLGASEEPLNSVLF-LRPISCGFLWESVDIQPPITPRY 587
VP A H +A GG L +AGGLG +E+ L+ + LR S W + P +P
Sbjct: 326 VPRAGHVMAAL---GGRLYVAGGLGETEDLLSFEAYELRTDS----W--THLAPLPSPHV 376
Query: 588 SHTAHVLNGKLLLVGG 603
+ VL G+LL++GG
Sbjct: 377 GAASAVLQGELLVLGG 392
>gi|47717139 leucine-zipper-like transcription regulator 1 [Homo
sapiens]
Length = 840
Score = 31.2 bits (69), Expect = 3.3
Identities = 24/84 (28%), Positives = 35/84 (41%), Gaps = 3/84 (3%)
Query: 521 WVRIPVEGEVPEARHS-HSACTWQGGALIAGGLGASEEPLNSVLFLRPISCGFLWESVDI 579
W R+P E AR S H+ ++ + GG + LN +L C +
Sbjct: 54 WRRLPPCDEFVGARRSKHTVVAYKDAIYVFGG-DNGKTMLNDLLRFDVKDCSWCRAFTTG 112
Query: 580 QPPITPRYSHTAHVLNGKLLLVGG 603
PP PRY H+A V + + GG
Sbjct: 113 TPP-APRYHHSAVVYGSSMFVFGG 135
>gi|8922528 kelch-like 11 [Homo sapiens]
Length = 708
Score = 31.2 bits (69), Expect = 3.3
Identities = 37/147 (25%), Positives = 53/147 (36%), Gaps = 22/147 (14%)
Query: 481 RHSTTEVSC-----QNQEYLFVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPEARH 535
+H T+ VS QN + + V GG S LS+ V WV +P +
Sbjct: 342 QHPTSHVSLLPRYGQNMDVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLP---HIHNHLD 398
Query: 536 SHSACTWQGGALIAG----GLGASEEPLNSVLFLRPISCGFLWESVDIQPPITPRYSHTA 591
H+ + +AG G + E N L C + T ++S
Sbjct: 399 GHAVAVTESYVYVAGSMEPGFAKTVERYNPNLNTWEHVCSLM----------TRKHSFGL 448
Query: 592 HVLNGKLLLVGGIWIHSSSFPGVTVIN 618
+ GKL +GG S F VTV N
Sbjct: 449 TEVKGKLYSIGGHGNFSPGFKDVTVYN 475
>gi|214831495 hypothetical protein LOC285679 [Homo sapiens]
Length = 277
Score = 30.8 bits (68), Expect = 4.4
Identities = 20/60 (33%), Positives = 25/60 (41%), Gaps = 3/60 (5%)
Query: 334 PASPSGVFPASVVSSEGQVPNLKRYGHASVFLSPDVILSAGGFGEQEGRHC---RVSQFH 390
PAS P S S G+ P+ R+ S F P +AG Q RH R+S H
Sbjct: 212 PASTLSPNPTSSTESLGETPHAGRWRQGSRFPQPGCANAAGRIRHQNPRHSHGHRISDIH 271
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 30.8 bits (68), Expect = 4.4
Identities = 43/189 (22%), Positives = 69/189 (36%), Gaps = 38/189 (20%)
Query: 426 SESRVLVLGGRLSPVSPALGVLQLHFFKSEDNNTEDLKVTITKAGRKDDSTLCCWRHSTT 485
S ++L+L G L P L + ++ E + L + + H
Sbjct: 319 SNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAH----------HCVV 368
Query: 486 EVSCQNQEYLFVYGGRSVVEPVLSDWHFLHVGTM------AWVRIPVEGEVPEARHSHSA 539
EV + +LFV GG P + H + + +W+++P + E R S A
Sbjct: 369 EV----ENFLFVLGGEDQWNP--NGKHSTNFVSRYDPRFNSWIQLP---PMQERRASFYA 419
Query: 540 CTWQGGALIAGGLGASEEPLNSVLFLRPISCGFL----WESVDIQPPITPRYSHTAHVLN 595
C + GG N +L + C L W V P P +H V N
Sbjct: 420 CRLDKHLYVIGGR-------NETGYLSSVECYNLETNEWRYVSSLPQ--PLAAHAGAVHN 470
Query: 596 GKLLLVGGI 604
GK+ + GG+
Sbjct: 471 GKIYISGGV 479
>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
isoform 1 [Homo sapiens]
Length = 937
Score = 30.0 bits (66), Expect = 7.4
Identities = 28/128 (21%), Positives = 49/128 (38%), Gaps = 3/128 (2%)
Query: 226 AFGQFMLQHFRQLNSPLHGLERFPDVEAQRRRFLQAGWTACGAVDMNEFYHCFLPAEERR 285
+FG + + F P +G +E R+R L C + C+ RR
Sbjct: 677 SFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRR 736
Query: 286 -RVENIEPFDEFEEWHLKCAHYFILAASRGDTLSHTLVFPSSEAFPRVNPASPSGVFPAS 344
R ++I W +H S G+ + T +S NP P+ +FP+
Sbjct: 737 PRFKDIHV--RLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRYPNYMFPSQ 794
Query: 345 VVSSEGQV 352
++ +GQ+
Sbjct: 795 GITPQGQI 802
>gi|8922640 kelch domain containing 8A [Homo sapiens]
Length = 350
Score = 30.0 bits (66), Expect = 7.4
Identities = 23/84 (27%), Positives = 38/84 (45%), Gaps = 4/84 (4%)
Query: 521 WVRIPVEGEVPEARHSHSACTWQGGALIAGGLGASEEPLNSVLFLRPISCGFLWESVDIQ 580
W+++ + + R A + G ++AGGLG L + P WE +
Sbjct: 255 WLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGK--NKWEILPAM 312
Query: 581 PPITPRYSHTAHVLNGKLLLVGGI 604
P TPR + ++ V+ LL VGG+
Sbjct: 313 P--TPRCACSSIVVKNCLLAVGGV 334
>gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]
Length = 954
Score = 29.6 bits (65), Expect = 9.7
Identities = 32/133 (24%), Positives = 51/133 (38%), Gaps = 16/133 (12%)
Query: 323 FPSSEAFPRVNPASPSGVFPASVVSSEGQVPNLKRYGHASVF----------LSPDVILS 372
FP S A V S G F +V + G P + + + F SPD++L
Sbjct: 740 FPGSGAVDEVGAGSGEG-FNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLV 798
Query: 373 AGGFGEQEGRHCRVSQFHLLSRDCDSEWKGSQIGSCGTGVQWDGRLYHTMTRLSESR--- 429
+ GF EG + +H +S C + G V H +T + ++
Sbjct: 799 SAGFDAAEGHPAPLGGYH-VSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEAC 857
Query: 430 -VLVLGGRLSPVS 441
+LG R+ P+S
Sbjct: 858 VAALLGNRVDPLS 870
>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
Length = 991
Score = 29.6 bits (65), Expect = 9.7
Identities = 32/133 (24%), Positives = 51/133 (38%), Gaps = 16/133 (12%)
Query: 323 FPSSEAFPRVNPASPSGVFPASVVSSEGQVPNLKRYGHASVF----------LSPDVILS 372
FP S A V S G F +V + G P + + + F SPD++L
Sbjct: 777 FPGSGAVDEVGAGSGEG-FNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLV 835
Query: 373 AGGFGEQEGRHCRVSQFHLLSRDCDSEWKGSQIGSCGTGVQWDGRLYHTMTRLSESR--- 429
+ GF EG + +H +S C + G V H +T + ++
Sbjct: 836 SAGFDAAEGHPAPLGGYH-VSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEAC 894
Query: 430 -VLVLGGRLSPVS 441
+LG R+ P+S
Sbjct: 895 VAALLGNRVDPLS 907
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,888,703
Number of Sequences: 37866
Number of extensions: 1310008
Number of successful extensions: 2582
Number of sequences better than 10.0: 23
Number of HSP's better than 10.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 2532
Number of HSP's gapped (non-prelim): 55
length of query: 686
length of database: 18,247,518
effective HSP length: 109
effective length of query: 577
effective length of database: 14,120,124
effective search space: 8147311548
effective search space used: 8147311548
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.