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Search of human proteins with 25121972
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25121972 copine VIII [Homo sapiens]
(564 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25121972 copine VIII [Homo sapiens] 1144 0.0
gi|25141323 copine V [Homo sapiens] 939 0.0
gi|88703066 copine-like protein [Homo sapiens] 880 0.0
gi|30181236 copine II [Homo sapiens] 545 e-155
gi|4503015 copine III [Homo sapiens] 543 e-154
gi|23397708 copine I isoform a [Homo sapiens] 526 e-149
gi|23397706 copine I isoform a [Homo sapiens] 526 e-149
gi|23397704 copine I isoform a [Homo sapiens] 526 e-149
gi|23397702 copine I isoform a [Homo sapiens] 526 e-149
gi|23397700 copine I isoform a [Homo sapiens] 526 e-149
gi|23397698 copine I isoform a [Homo sapiens] 526 e-149
gi|23397696 copine I isoform a [Homo sapiens] 526 e-149
gi|197333761 copine I isoform b [Homo sapiens] 526 e-149
gi|18677733 copine IV [Homo sapiens] 525 e-149
gi|25141328 copine 7 isoform a [Homo sapiens] 508 e-144
gi|5174421 copine 6 [Homo sapiens] 494 e-139
gi|7656993 copine 7 isoform b [Homo sapiens] 421 e-118
gi|13384594 protein kinase C, gamma [Homo sapiens] 54 3e-07
gi|39752671 synaptotagmin X [Homo sapiens] 52 1e-06
gi|4506067 protein kinase C, alpha [Homo sapiens] 50 5e-06
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo... 50 5e-06
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom... 50 5e-06
gi|28376627 synaptotagmin IX [Homo sapiens] 49 1e-05
gi|209447073 synaptotagmin I [Homo sapiens] 49 2e-05
gi|5032139 synaptotagmin I [Homo sapiens] 49 2e-05
gi|209447070 synaptotagmin I [Homo sapiens] 49 2e-05
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 48 2e-05
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 48 2e-05
gi|92859638 synaptotagmin V [Homo sapiens] 48 3e-05
gi|238550198 synaptotagmin III [Homo sapiens] 47 5e-05
>gi|25121972 copine VIII [Homo sapiens]
Length = 564
Score = 1144 bits (2958), Expect = 0.0
Identities = 564/564 (100%), Positives = 564/564 (100%)
Query: 1 MDSRYNSTAGIGDLNQLSAAIPATRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEW 60
MDSRYNSTAGIGDLNQLSAAIPATRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEW
Sbjct: 1 MDSRYNSTAGIGDLNQLSAAIPATRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEW 60
Query: 61 REFGRTEVIDNTLNPDFVRKFILDYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTL 120
REFGRTEVIDNTLNPDFVRKFILDYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTL
Sbjct: 61 REFGRTEVIDNTLNPDFVRKFILDYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTL 120
Query: 121 GEIVGSQGSRLEKPIVGIPGKKCGTIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDP 180
GEIVGSQGSRLEKPIVGIPGKKCGTIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDP
Sbjct: 121 GEIVGSQGSRLEKPIVGIPGKKCGTIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDP 180
Query: 181 FLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDG 240
FLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDG
Sbjct: 181 FLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDG 240
Query: 241 SHDFIGEFTTSYRELSRGQSQFNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLD 300
SHDFIGEFTTSYRELSRGQSQFNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLD
Sbjct: 241 SHDFIGEFTTSYRELSRGQSQFNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLD 300
Query: 301 YIKGGTQINFTVAIDFTASNGNPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMF 360
YIKGGTQINFTVAIDFTASNGNPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMF
Sbjct: 301 YIKGGTQINFTVAIDFTASNGNPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMF 360
Query: 361 PALGFGAKLPPDGRISHEFALNGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVIN 420
PALGFGAKLPPDGRISHEFALNGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVIN
Sbjct: 361 PALGFGAKLPPDGRISHEFALNGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVIN 420
Query: 421 HVARYASSVKDGSQYFVLLIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMV 480
HVARYASSVKDGSQYFVLLIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMV
Sbjct: 421 HVARYASSVKDGSQYFVLLIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMV 480
Query: 481 ELDGDDVRVSSRGKYAERDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMR 540
ELDGDDVRVSSRGKYAERDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMR
Sbjct: 481 ELDGDDVRVSSRGKYAERDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMR 540
Query: 541 ARGIKPSPAPPPYTPPTHVLQTQI 564
ARGIKPSPAPPPYTPPTHVLQTQI
Sbjct: 541 ARGIKPSPAPPPYTPPTHVLQTQI 564
>gi|25141323 copine V [Homo sapiens]
Length = 593
Score = 939 bits (2427), Expect = 0.0
Identities = 455/586 (77%), Positives = 511/586 (87%), Gaps = 30/586 (5%)
Query: 9 AGIGDLNQLSAAIPATRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEV 68
A + + + L+ +IPAT+VE++VSCRNLLD+D FSKSDP+CV+Y QG+ NK+WREFGRTEV
Sbjct: 8 ASLSEFDSLAGSIPATKVEITVSCRNLLDKDMFSKSDPLCVMYTQGMENKQWREFGRTEV 67
Query: 69 IDNTLNPDFVRKFILDYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQG 128
IDNTLNPDFVRKFI+DYFFEE++NLRFDLYDVDSKSP+LSKHDFLGQ FCTLGEIVGS G
Sbjct: 68 IDNTLNPDFVRKFIVDYFFEEKQNLRFDLYDVDSKSPDLSKHDFLGQAFCTLGEIVGSPG 127
Query: 129 SRLEKPIV--------------------GIPGKKCGTIILTAEELNCCRDAVLMQFCANK 168
SRLEKP+ G+PGKKCGTIIL+AEEL+ CRD MQFCANK
Sbjct: 128 SRLEKPLTIGAFSLNSRTGKPMPAVSNGGVPGKKCGTIILSAEELSNCRDVATMQFCANK 187
Query: 169 LDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKISVRALCNGDYDRT 228
LDKKDFFGKSDPFLVFYRSNEDG+FTICHKTEV+KNTLNPVWQ F I VRALCNGDYDRT
Sbjct: 188 LDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVMKNTLNPVWQTFSIPVRALCNGDYDRT 247
Query: 229 IKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQFNVYEVVNPKKKGKKKKYTNSGTVTLL 288
IKVEVYDWDRDGSHDFIGEFTTSYREL+RGQSQFN+YEVVNPKKK KKKKY NSGTVTLL
Sbjct: 248 IKVEVYDWDRDGSHDFIGEFTTSYRELARGQSQFNIYEVVNPKKKMKKKKYVNSGTVTLL 307
Query: 289 SFLVETEVSFLDYIKGGTQINFTVAIDFTASNGNPAQPTSLHYMNPYQLNAYGMALKAVG 348
SF VE+E +FLDYIKGGTQINFTVAIDFTASNGNP+Q TSLHYM+PYQLNAY +AL AVG
Sbjct: 308 SFAVESECTFLDYIKGGTQINFTVAIDFTASNGNPSQSTSLHYMSPYQLNAYALALTAVG 367
Query: 349 EIVQDYDSDKMFPALGFGAKLPPDGRISHEFALNGNPQNPYCDGIEGVMEAYYRSLKSVQ 408
EI+Q YDSDKMFPALGFGAKLPPDGR+SHEF LNGN +NP C GI+G++EAY+RSL++VQ
Sbjct: 368 EIIQHYDSDKMFPALGFGAKLPPDGRVSHEFPLNGNQENPSCCGIDGILEAYHRSLRTVQ 427
Query: 409 LYGPTNFAPVINHVARYASSVKDGSQYFVLLIVTDGVISDMAQTKESIVNASKLPMSIII 468
LYGPTNFAPV+ HVAR A++V+DGSQY VLLI+TDGVISDMAQTKE+IVNA+KLPMSIII
Sbjct: 428 LYGPTNFAPVVTHVARNAAAVQDGSQYSVLLIITDGVISDMAQTKEAIVNAAKLPMSIII 487
Query: 469 VGVGPAEFDAMVELDGDDVRVSSRGKYAERDIVQFVPFRDYIDRSGNHILSMARLAKDVL 528
VGVG AEFDAMVELDGDDVR+SSRGK AERDIVQFVPFRDY+DR+GNH+LSMARLA+DVL
Sbjct: 488 VGVGQAEFDAMVELDGDDVRISSRGKLAERDIVQFVPFRDYVDRTGNHVLSMARLARDVL 547
Query: 529 AEIPEQFLSYMRARGIKPSPAP----------PPYTPPTHVLQTQI 564
AEIP+Q +SYM+A+GI+P P P P TPP L T I
Sbjct: 548 AEIPDQLVSYMKAQGIRPRPPPAAPTHSPSQSPARTPPASPLHTHI 593
>gi|88703066 copine-like protein [Homo sapiens]
Length = 553
Score = 880 bits (2275), Expect = 0.0
Identities = 420/538 (78%), Positives = 482/538 (89%), Gaps = 2/538 (0%)
Query: 20 AIPATRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVR 79
++PAT++E++VSCRNLLD DTFSKSDP+ VLY Q ++EWREFGRTEVIDNTLNPDFVR
Sbjct: 10 SVPATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVR 69
Query: 80 KFILDYFFEERENLRFDLYDVDSKSPNLSK-HDFLGQVFCTLGEIVGSQGSRLEKPIVGI 138
KF+LDYFFEE++NLRFD+Y+VDSK+ N+SK DFLGQ F LGE++G QGSR+E+ + G+
Sbjct: 70 KFVLDYFFEEKQNLRFDVYNVDSKT-NISKPKDFLGQAFLALGEVIGGQGSRVERTLTGV 128
Query: 139 PGKKCGTIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHK 198
PGKKCGTI+LTAEEL+ CRD MQ CANKLDKKDFFGKSDPFLVFYRSNEDG+FTICHK
Sbjct: 129 PGKKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHK 188
Query: 199 TEVVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRG 258
TEVVKNTLNPVWQ F I VRALCNGDYDRT+K++VYDWDRDGSHDFIGEFTTSYRELS+
Sbjct: 189 TEVVKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKA 248
Query: 259 QSQFNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTA 318
Q+QF VYEV+NP+KK KKKKY NSGTVTLLSF V++E +F+DYIKGGTQ+NFTVAIDFTA
Sbjct: 249 QNQFTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTA 308
Query: 319 SNGNPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHE 378
SNGNP QPTSLHYM+PYQL+AY MALKAVGEI+QDYDSDK+FPA GFGAKLPP+GRISH+
Sbjct: 309 SNGNPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQ 368
Query: 379 FALNGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYASSVKDGSQYFVL 438
F LN N ++P C GIEGV+E+Y++SL++VQLYGPT FAPVIN VAR A+ + DGSQY+VL
Sbjct: 369 FPLNNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKISDGSQYYVL 428
Query: 439 LIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRVSSRGKYAER 498
LI+TDGVISDM QTKE+IV+AS LPMSIIIVGVGPA F+AM ELDGDDVRVSSRG+YAER
Sbjct: 429 LIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVSSRGRYAER 488
Query: 499 DIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKPSPAPPPYTPP 556
DIVQFVPFRDY+DRSGN +LSMARLAKDVLAEIPEQ LSYMR R I+P P PP P
Sbjct: 489 DIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQPRPPPPANPSP 546
>gi|30181236 copine II [Homo sapiens]
Length = 548
Score = 545 bits (1405), Expect = e-155
Identities = 275/534 (51%), Positives = 373/534 (69%), Gaps = 18/534 (3%)
Query: 25 RVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFILD 84
+VE+SVS +NLLDRD SKSDP CVL+ + N W E+ RTE N LNP F +KF+LD
Sbjct: 25 KVELSVSGQNLLDRDVTSKSDPFCVLFTEN--NGRWIEYDRTETAINNLNPAFSKKFVLD 82
Query: 85 YFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKKCG 144
Y FEE + L+F L+D D S L +HDFLGQ C+LG IV S+ ++ +P++ + K G
Sbjct: 83 YHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSK--KITRPLLLLNDKPAG 140
Query: 145 TIILT--AEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVV 202
++T A+EL+ R + + +LDKKD FGKSDPFL FY+ +DG + + H+TEV+
Sbjct: 141 KGLITIAAQELSDNR-VITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVI 199
Query: 203 KNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQF 262
K TL+PVW+ F + + +LC+GD ++ I+V YD+D DG HDFIGEF TS ++ +
Sbjct: 200 KYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSV 259
Query: 263 NV-YEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTASNG 321
+ +E +NPKK+ KKK Y NSG + L S + + SFLDYI GG Q+ FTV IDFTASNG
Sbjct: 260 PLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNG 319
Query: 322 NPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHEFAL 381
NP P+SLHY+NP N Y A+ AVG+I+QDYDSDKMFPALGFGA+LPPD ++SHEFA+
Sbjct: 320 NPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAI 379
Query: 382 NGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYASSV---KDGSQYFVL 438
N NP NP+C G++G+ +AY L ++ YGPTNF+P++NHVAR+A+ + +QYF+L
Sbjct: 380 NFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFIL 439
Query: 439 LIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRVSSR-GKYAE 497
LI+TDGVISDM +T+ ++V ASKLPMSIIIVGVG A+F AM LDGD + S G+ A
Sbjct: 440 LIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAA 499
Query: 498 RDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKPSPAPP 551
RDIVQFVPFR++ + + LAK VLAE+P+Q + Y + + + P+ + P
Sbjct: 500 RDIVQFVPFREFRN------AAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEP 547
>gi|4503015 copine III [Homo sapiens]
Length = 537
Score = 543 bits (1399), Expect = e-154
Identities = 281/539 (52%), Positives = 377/539 (69%), Gaps = 17/539 (3%)
Query: 19 AAIPATRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFV 78
AA T+V ++VSC NLLD+D SKSDP+CVL++ G ++W E RTE I N LNP F
Sbjct: 2 AAQCVTKVALNVSCANLLDKDIGSKSDPLCVLFLNTSG-QQWYEVERTERIKNCLNPQFS 60
Query: 79 RKFILDYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGI 138
+ FI+DY+FE + L+F +YD+D+K+ LS DFLG+ CTLG+IV S+ +L +P+V
Sbjct: 61 KTFIIDYYFEVVQKLKFGVYDIDNKTIELSDDDFLGECECTLGQIVSSK--KLTRPLVMK 118
Query: 139 PGKKCG--TIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTIC 196
G+ G +I ++AEE+ R VL + A KLD KD FGKSDP+L F++ DG++ +
Sbjct: 119 TGRPAGKGSITISAEEIKDNR-VVLFEMEARKLDNKDLFGKSDPYLEFHKQTSDGNWLMV 177
Query: 197 HKTEVVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELS 256
H+TEVVKN LNPVW+ FKIS+ +LC GD D+TIKVE YD+D DGSHD IG F T+ +L
Sbjct: 178 HRTEVVKNNLNPVWRPFKISLNSLCYGDMDKTIKVECYDYDNDGSHDLIGTFQTTMTKLK 237
Query: 257 RGQSQFNV-YEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAID 315
V +E +N KK+ KKK Y NSG +++ + E +FLDYI GG Q+NFTV +D
Sbjct: 238 EASRSSPVEFECINEKKRQKKKSYKNSGVISVKQCEITVECTFLDYIMGGCQLNFTVGVD 297
Query: 316 FTASNGNPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRI 375
FT SNG+P P SLHY++P +N Y AL +VG ++QDYD+DKMFPA GFGA++PP ++
Sbjct: 298 FTGSNGDPRSPDSLHYISPNGVNEYLTALWSVGLVIQDYDADKMFPAFGFGAQIPPQWQV 357
Query: 376 SHEFALNGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYASSV---KDG 432
SHEF +N NP NPYC+GI+G++EAY L ++LYGPTNF+P+INHVAR+A++ +
Sbjct: 358 SHEFPMNFNPSNPYCNGIQGIVEAYRSCLPQIKLYGPTNFSPIINHVARFAAAATQQQTA 417
Query: 433 SQYFVLLIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRV-SS 491
SQYFVLLI+TDGVI+D+ +T+++IVNAS+LPMSIIIVGVG A+F AM LDGD + S
Sbjct: 418 SQYFVLLIITDGVITDLDETRQAIVNASRLPMSIIIVGVGGADFSAMEFLDGDGGSLRSP 477
Query: 492 RGKYAERDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKPSPAP 550
G+ A RDIVQFVPFR + + LA+ VLAEIP+Q + Y + P P
Sbjct: 478 LGEVAIRDIVQFVPFRQFQN------APKEALAQCVLAEIPQQVVGYFNTYKLLPPKNP 530
>gi|23397708 copine I isoform a [Homo sapiens]
Length = 537
Score = 526 bits (1355), Expect = e-149
Identities = 277/545 (50%), Positives = 373/545 (68%), Gaps = 21/545 (3%)
Query: 24 TRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFIL 83
T V++S+SC +L+D+D SKSDP+CVL +Q VG W E GRTE + N +P+F + L
Sbjct: 6 TLVQLSISCDHLIDKDIGSKSDPLCVL-LQDVGGGSWAELGRTERVRNCSSPEFSKTLQL 64
Query: 84 DYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKKC 143
+Y FE + LRF +YD+D+K+P L DFLG C+LG+IV SQ L P++ PGK
Sbjct: 65 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTL--PLMLKPGKPA 122
Query: 144 G--TIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEV 201
G TI ++A+EL R V M+ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 123 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 180
Query: 202 VKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQ 261
+KN LNP W+ F + V+ C G+ I+V+ D+D DGSHD IG F TS +L ++
Sbjct: 181 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 240
Query: 262 FNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTASNG 321
F E ++P+K+ KKK Y NSGT+ + VETE SFLDY+ GG QINFTV +DFT SNG
Sbjct: 241 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 322 NPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHEFAL 381
+P+ P SLHY++P +N Y MAL +VG +VQDYDSDK+FPA GFGA++PPD ++SHEFAL
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 382 NGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYASSVK---DGSQYFVL 438
N NP NPYC GI+G+++AY ++L V+LYGPTNFAP+INHVAR+A+ SQYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 439 LIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRVSSR-GKYAE 497
L++TDG ++D+ T+E++V AS LPMS+IIVGVG A+F+AM +LD D + +R G+ A
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 498 RDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKP-SPAPPPYTPP 556
RDIVQFVP+R + + LA+ VLAE+P Q +SY RA+G P P PP P
Sbjct: 478 RDIVQFVPYRRFQN------APREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 531
Query: 557 THVLQ 561
Q
Sbjct: 532 AQAPQ 536
Score = 30.0 bits (66), Expect = 5.9
Identities = 26/108 (24%), Positives = 44/108 (40%), Gaps = 7/108 (6%)
Query: 156 CRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKI 215
C V + + L KD KSDP V + GS+ +TE V+N +P F
Sbjct: 4 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---EFSK 60
Query: 216 SVRALCNGDYDRTIKVEVYDWDRD----GSHDFIGEFTTSYRELSRGQ 259
+++ + + ++ +YD D DF+G S ++ Q
Sbjct: 61 TLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ 108
>gi|23397706 copine I isoform a [Homo sapiens]
Length = 537
Score = 526 bits (1355), Expect = e-149
Identities = 277/545 (50%), Positives = 373/545 (68%), Gaps = 21/545 (3%)
Query: 24 TRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFIL 83
T V++S+SC +L+D+D SKSDP+CVL +Q VG W E GRTE + N +P+F + L
Sbjct: 6 TLVQLSISCDHLIDKDIGSKSDPLCVL-LQDVGGGSWAELGRTERVRNCSSPEFSKTLQL 64
Query: 84 DYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKKC 143
+Y FE + LRF +YD+D+K+P L DFLG C+LG+IV SQ L P++ PGK
Sbjct: 65 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTL--PLMLKPGKPA 122
Query: 144 G--TIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEV 201
G TI ++A+EL R V M+ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 123 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 180
Query: 202 VKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQ 261
+KN LNP W+ F + V+ C G+ I+V+ D+D DGSHD IG F TS +L ++
Sbjct: 181 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 240
Query: 262 FNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTASNG 321
F E ++P+K+ KKK Y NSGT+ + VETE SFLDY+ GG QINFTV +DFT SNG
Sbjct: 241 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 322 NPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHEFAL 381
+P+ P SLHY++P +N Y MAL +VG +VQDYDSDK+FPA GFGA++PPD ++SHEFAL
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 382 NGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYASSVK---DGSQYFVL 438
N NP NPYC GI+G+++AY ++L V+LYGPTNFAP+INHVAR+A+ SQYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 439 LIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRVSSR-GKYAE 497
L++TDG ++D+ T+E++V AS LPMS+IIVGVG A+F+AM +LD D + +R G+ A
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 498 RDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKP-SPAPPPYTPP 556
RDIVQFVP+R + + LA+ VLAE+P Q +SY RA+G P P PP P
Sbjct: 478 RDIVQFVPYRRFQN------APREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 531
Query: 557 THVLQ 561
Q
Sbjct: 532 AQAPQ 536
Score = 30.0 bits (66), Expect = 5.9
Identities = 26/108 (24%), Positives = 44/108 (40%), Gaps = 7/108 (6%)
Query: 156 CRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKI 215
C V + + L KD KSDP V + GS+ +TE V+N +P F
Sbjct: 4 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---EFSK 60
Query: 216 SVRALCNGDYDRTIKVEVYDWDRD----GSHDFIGEFTTSYRELSRGQ 259
+++ + + ++ +YD D DF+G S ++ Q
Sbjct: 61 TLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ 108
>gi|23397704 copine I isoform a [Homo sapiens]
Length = 537
Score = 526 bits (1355), Expect = e-149
Identities = 277/545 (50%), Positives = 373/545 (68%), Gaps = 21/545 (3%)
Query: 24 TRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFIL 83
T V++S+SC +L+D+D SKSDP+CVL +Q VG W E GRTE + N +P+F + L
Sbjct: 6 TLVQLSISCDHLIDKDIGSKSDPLCVL-LQDVGGGSWAELGRTERVRNCSSPEFSKTLQL 64
Query: 84 DYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKKC 143
+Y FE + LRF +YD+D+K+P L DFLG C+LG+IV SQ L P++ PGK
Sbjct: 65 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTL--PLMLKPGKPA 122
Query: 144 G--TIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEV 201
G TI ++A+EL R V M+ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 123 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 180
Query: 202 VKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQ 261
+KN LNP W+ F + V+ C G+ I+V+ D+D DGSHD IG F TS +L ++
Sbjct: 181 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 240
Query: 262 FNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTASNG 321
F E ++P+K+ KKK Y NSGT+ + VETE SFLDY+ GG QINFTV +DFT SNG
Sbjct: 241 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 322 NPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHEFAL 381
+P+ P SLHY++P +N Y MAL +VG +VQDYDSDK+FPA GFGA++PPD ++SHEFAL
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 382 NGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYASSVK---DGSQYFVL 438
N NP NPYC GI+G+++AY ++L V+LYGPTNFAP+INHVAR+A+ SQYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 439 LIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRVSSR-GKYAE 497
L++TDG ++D+ T+E++V AS LPMS+IIVGVG A+F+AM +LD D + +R G+ A
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 498 RDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKP-SPAPPPYTPP 556
RDIVQFVP+R + + LA+ VLAE+P Q +SY RA+G P P PP P
Sbjct: 478 RDIVQFVPYRRFQN------APREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 531
Query: 557 THVLQ 561
Q
Sbjct: 532 AQAPQ 536
Score = 30.0 bits (66), Expect = 5.9
Identities = 26/108 (24%), Positives = 44/108 (40%), Gaps = 7/108 (6%)
Query: 156 CRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKI 215
C V + + L KD KSDP V + GS+ +TE V+N +P F
Sbjct: 4 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---EFSK 60
Query: 216 SVRALCNGDYDRTIKVEVYDWDRD----GSHDFIGEFTTSYRELSRGQ 259
+++ + + ++ +YD D DF+G S ++ Q
Sbjct: 61 TLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ 108
>gi|23397702 copine I isoform a [Homo sapiens]
Length = 537
Score = 526 bits (1355), Expect = e-149
Identities = 277/545 (50%), Positives = 373/545 (68%), Gaps = 21/545 (3%)
Query: 24 TRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFIL 83
T V++S+SC +L+D+D SKSDP+CVL +Q VG W E GRTE + N +P+F + L
Sbjct: 6 TLVQLSISCDHLIDKDIGSKSDPLCVL-LQDVGGGSWAELGRTERVRNCSSPEFSKTLQL 64
Query: 84 DYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKKC 143
+Y FE + LRF +YD+D+K+P L DFLG C+LG+IV SQ L P++ PGK
Sbjct: 65 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTL--PLMLKPGKPA 122
Query: 144 G--TIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEV 201
G TI ++A+EL R V M+ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 123 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 180
Query: 202 VKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQ 261
+KN LNP W+ F + V+ C G+ I+V+ D+D DGSHD IG F TS +L ++
Sbjct: 181 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 240
Query: 262 FNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTASNG 321
F E ++P+K+ KKK Y NSGT+ + VETE SFLDY+ GG QINFTV +DFT SNG
Sbjct: 241 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 322 NPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHEFAL 381
+P+ P SLHY++P +N Y MAL +VG +VQDYDSDK+FPA GFGA++PPD ++SHEFAL
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 382 NGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYASSVK---DGSQYFVL 438
N NP NPYC GI+G+++AY ++L V+LYGPTNFAP+INHVAR+A+ SQYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 439 LIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRVSSR-GKYAE 497
L++TDG ++D+ T+E++V AS LPMS+IIVGVG A+F+AM +LD D + +R G+ A
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 498 RDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKP-SPAPPPYTPP 556
RDIVQFVP+R + + LA+ VLAE+P Q +SY RA+G P P PP P
Sbjct: 478 RDIVQFVPYRRFQN------APREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 531
Query: 557 THVLQ 561
Q
Sbjct: 532 AQAPQ 536
Score = 30.0 bits (66), Expect = 5.9
Identities = 26/108 (24%), Positives = 44/108 (40%), Gaps = 7/108 (6%)
Query: 156 CRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKI 215
C V + + L KD KSDP V + GS+ +TE V+N +P F
Sbjct: 4 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---EFSK 60
Query: 216 SVRALCNGDYDRTIKVEVYDWDRD----GSHDFIGEFTTSYRELSRGQ 259
+++ + + ++ +YD D DF+G S ++ Q
Sbjct: 61 TLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ 108
>gi|23397700 copine I isoform a [Homo sapiens]
Length = 537
Score = 526 bits (1355), Expect = e-149
Identities = 277/545 (50%), Positives = 373/545 (68%), Gaps = 21/545 (3%)
Query: 24 TRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFIL 83
T V++S+SC +L+D+D SKSDP+CVL +Q VG W E GRTE + N +P+F + L
Sbjct: 6 TLVQLSISCDHLIDKDIGSKSDPLCVL-LQDVGGGSWAELGRTERVRNCSSPEFSKTLQL 64
Query: 84 DYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKKC 143
+Y FE + LRF +YD+D+K+P L DFLG C+LG+IV SQ L P++ PGK
Sbjct: 65 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTL--PLMLKPGKPA 122
Query: 144 G--TIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEV 201
G TI ++A+EL R V M+ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 123 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 180
Query: 202 VKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQ 261
+KN LNP W+ F + V+ C G+ I+V+ D+D DGSHD IG F TS +L ++
Sbjct: 181 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 240
Query: 262 FNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTASNG 321
F E ++P+K+ KKK Y NSGT+ + VETE SFLDY+ GG QINFTV +DFT SNG
Sbjct: 241 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 322 NPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHEFAL 381
+P+ P SLHY++P +N Y MAL +VG +VQDYDSDK+FPA GFGA++PPD ++SHEFAL
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 382 NGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYASSVK---DGSQYFVL 438
N NP NPYC GI+G+++AY ++L V+LYGPTNFAP+INHVAR+A+ SQYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 439 LIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRVSSR-GKYAE 497
L++TDG ++D+ T+E++V AS LPMS+IIVGVG A+F+AM +LD D + +R G+ A
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 498 RDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKP-SPAPPPYTPP 556
RDIVQFVP+R + + LA+ VLAE+P Q +SY RA+G P P PP P
Sbjct: 478 RDIVQFVPYRRFQN------APREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 531
Query: 557 THVLQ 561
Q
Sbjct: 532 AQAPQ 536
Score = 30.0 bits (66), Expect = 5.9
Identities = 26/108 (24%), Positives = 44/108 (40%), Gaps = 7/108 (6%)
Query: 156 CRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKI 215
C V + + L KD KSDP V + GS+ +TE V+N +P F
Sbjct: 4 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---EFSK 60
Query: 216 SVRALCNGDYDRTIKVEVYDWDRD----GSHDFIGEFTTSYRELSRGQ 259
+++ + + ++ +YD D DF+G S ++ Q
Sbjct: 61 TLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ 108
>gi|23397698 copine I isoform a [Homo sapiens]
Length = 537
Score = 526 bits (1355), Expect = e-149
Identities = 277/545 (50%), Positives = 373/545 (68%), Gaps = 21/545 (3%)
Query: 24 TRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFIL 83
T V++S+SC +L+D+D SKSDP+CVL +Q VG W E GRTE + N +P+F + L
Sbjct: 6 TLVQLSISCDHLIDKDIGSKSDPLCVL-LQDVGGGSWAELGRTERVRNCSSPEFSKTLQL 64
Query: 84 DYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKKC 143
+Y FE + LRF +YD+D+K+P L DFLG C+LG+IV SQ L P++ PGK
Sbjct: 65 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTL--PLMLKPGKPA 122
Query: 144 G--TIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEV 201
G TI ++A+EL R V M+ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 123 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 180
Query: 202 VKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQ 261
+KN LNP W+ F + V+ C G+ I+V+ D+D DGSHD IG F TS +L ++
Sbjct: 181 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 240
Query: 262 FNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTASNG 321
F E ++P+K+ KKK Y NSGT+ + VETE SFLDY+ GG QINFTV +DFT SNG
Sbjct: 241 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 322 NPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHEFAL 381
+P+ P SLHY++P +N Y MAL +VG +VQDYDSDK+FPA GFGA++PPD ++SHEFAL
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 382 NGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYASSVK---DGSQYFVL 438
N NP NPYC GI+G+++AY ++L V+LYGPTNFAP+INHVAR+A+ SQYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 439 LIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRVSSR-GKYAE 497
L++TDG ++D+ T+E++V AS LPMS+IIVGVG A+F+AM +LD D + +R G+ A
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 498 RDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKP-SPAPPPYTPP 556
RDIVQFVP+R + + LA+ VLAE+P Q +SY RA+G P P PP P
Sbjct: 478 RDIVQFVPYRRFQN------APREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 531
Query: 557 THVLQ 561
Q
Sbjct: 532 AQAPQ 536
Score = 30.0 bits (66), Expect = 5.9
Identities = 26/108 (24%), Positives = 44/108 (40%), Gaps = 7/108 (6%)
Query: 156 CRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKI 215
C V + + L KD KSDP V + GS+ +TE V+N +P F
Sbjct: 4 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---EFSK 60
Query: 216 SVRALCNGDYDRTIKVEVYDWDRD----GSHDFIGEFTTSYRELSRGQ 259
+++ + + ++ +YD D DF+G S ++ Q
Sbjct: 61 TLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ 108
>gi|23397696 copine I isoform a [Homo sapiens]
Length = 537
Score = 526 bits (1355), Expect = e-149
Identities = 277/545 (50%), Positives = 373/545 (68%), Gaps = 21/545 (3%)
Query: 24 TRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFIL 83
T V++S+SC +L+D+D SKSDP+CVL +Q VG W E GRTE + N +P+F + L
Sbjct: 6 TLVQLSISCDHLIDKDIGSKSDPLCVL-LQDVGGGSWAELGRTERVRNCSSPEFSKTLQL 64
Query: 84 DYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKKC 143
+Y FE + LRF +YD+D+K+P L DFLG C+LG+IV SQ L P++ PGK
Sbjct: 65 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTL--PLMLKPGKPA 122
Query: 144 G--TIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEV 201
G TI ++A+EL R V M+ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 123 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 180
Query: 202 VKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQ 261
+KN LNP W+ F + V+ C G+ I+V+ D+D DGSHD IG F TS +L ++
Sbjct: 181 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 240
Query: 262 FNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTASNG 321
F E ++P+K+ KKK Y NSGT+ + VETE SFLDY+ GG QINFTV +DFT SNG
Sbjct: 241 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 322 NPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHEFAL 381
+P+ P SLHY++P +N Y MAL +VG +VQDYDSDK+FPA GFGA++PPD ++SHEFAL
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 382 NGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYASSVK---DGSQYFVL 438
N NP NPYC GI+G+++AY ++L V+LYGPTNFAP+INHVAR+A+ SQYF+L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 439 LIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRVSSR-GKYAE 497
L++TDG ++D+ T+E++V AS LPMS+IIVGVG A+F+AM +LD D + +R G+ A
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 498 RDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKP-SPAPPPYTPP 556
RDIVQFVP+R + + LA+ VLAE+P Q +SY RA+G P P PP P
Sbjct: 478 RDIVQFVPYRRFQN------APREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 531
Query: 557 THVLQ 561
Q
Sbjct: 532 AQAPQ 536
Score = 30.0 bits (66), Expect = 5.9
Identities = 26/108 (24%), Positives = 44/108 (40%), Gaps = 7/108 (6%)
Query: 156 CRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKI 215
C V + + L KD KSDP V + GS+ +TE V+N +P F
Sbjct: 4 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---EFSK 60
Query: 216 SVRALCNGDYDRTIKVEVYDWDRD----GSHDFIGEFTTSYRELSRGQ 259
+++ + + ++ +YD D DF+G S ++ Q
Sbjct: 61 TLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ 108
>gi|197333761 copine I isoform b [Homo sapiens]
Length = 542
Score = 526 bits (1355), Expect = e-149
Identities = 277/545 (50%), Positives = 373/545 (68%), Gaps = 21/545 (3%)
Query: 24 TRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFIL 83
T V++S+SC +L+D+D SKSDP+CVL +Q VG W E GRTE + N +P+F + L
Sbjct: 11 TLVQLSISCDHLIDKDIGSKSDPLCVL-LQDVGGGSWAELGRTERVRNCSSPEFSKTLQL 69
Query: 84 DYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKKC 143
+Y FE + LRF +YD+D+K+P L DFLG C+LG+IV SQ L P++ PGK
Sbjct: 70 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTL--PLMLKPGKPA 127
Query: 144 G--TIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEV 201
G TI ++A+EL R V M+ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 128 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 185
Query: 202 VKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQ 261
+KN LNP W+ F + V+ C G+ I+V+ D+D DGSHD IG F TS +L ++
Sbjct: 186 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 245
Query: 262 FNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTASNG 321
F E ++P+K+ KKK Y NSGT+ + VETE SFLDY+ GG QINFTV +DFT SNG
Sbjct: 246 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 302
Query: 322 NPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHEFAL 381
+P+ P SLHY++P +N Y MAL +VG +VQDYDSDK+FPA GFGA++PPD ++SHEFAL
Sbjct: 303 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 362
Query: 382 NGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYASSVK---DGSQYFVL 438
N NP NPYC GI+G+++AY ++L V+LYGPTNFAP+INHVAR+A+ SQYF+L
Sbjct: 363 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 422
Query: 439 LIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRVSSR-GKYAE 497
L++TDG ++D+ T+E++V AS LPMS+IIVGVG A+F+AM +LD D + +R G+ A
Sbjct: 423 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 482
Query: 498 RDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKP-SPAPPPYTPP 556
RDIVQFVP+R + + LA+ VLAE+P Q +SY RA+G P P PP P
Sbjct: 483 RDIVQFVPYRRFQN------APREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 536
Query: 557 THVLQ 561
Q
Sbjct: 537 AQAPQ 541
Score = 30.0 bits (66), Expect = 5.9
Identities = 26/108 (24%), Positives = 44/108 (40%), Gaps = 7/108 (6%)
Query: 156 CRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKI 215
C V + + L KD KSDP V + GS+ +TE V+N +P F
Sbjct: 9 CVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---EFSK 65
Query: 216 SVRALCNGDYDRTIKVEVYDWDRD----GSHDFIGEFTTSYRELSRGQ 259
+++ + + ++ +YD D DF+G S ++ Q
Sbjct: 66 TLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ 113
>gi|18677733 copine IV [Homo sapiens]
Length = 557
Score = 525 bits (1352), Expect = e-149
Identities = 282/538 (52%), Positives = 366/538 (68%), Gaps = 20/538 (3%)
Query: 24 TRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFIL 83
T+VE+ V+C+ + DRD SK DP +L +Q G +W E RTEVI +NP + + F +
Sbjct: 24 TKVELRVACKGISDRDALSKPDPCVILKMQSHG--QWFEVDRTEVIRTCINPVYSKLFTV 81
Query: 84 DYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIV---GIPG 140
D++FEE + LRF+++D+ S L + DFLG + CTLG+IV + +L K ++ G
Sbjct: 82 DFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQR--KLSKSLLKHGNTAG 139
Query: 141 KKCGTIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTE 200
K T+I AEEL+ D V + F A KLD KDFF KSDPFL +R N+D + + H+TE
Sbjct: 140 KSSITVI--AEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTE 197
Query: 201 VVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQS 260
VV N L+P W++FK+SV +LC+GD DR +K V+DWD +G HDFIGEFT++++E+
Sbjct: 198 VVMNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAME 257
Query: 261 QFNV-YEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTAS 319
V +E +NPK K KKK Y NSGTV L + SFLDYI GG QI FTVAIDFTAS
Sbjct: 258 GKQVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTAS 317
Query: 320 NGNPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHEF 379
NG+P SLHY++PYQ N Y AL AVGEI QDYDSDKMFPA GFGA++PP+ +SH+F
Sbjct: 318 NGDPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDF 377
Query: 380 ALNGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYAS---SVKDGSQYF 436
A+N N NP C GI+GV+EAY L +QLYGPTN AP+I VA+ AS + K+ SQYF
Sbjct: 378 AINFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYF 437
Query: 437 VLLIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDD-VRVSSRGKY 495
+LLI+TDGVI+DMA T+E+IV+AS LPMS+IIVGVG A+F M LDGDD + S +G+
Sbjct: 438 ILLILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEP 497
Query: 496 AERDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKPSPAPPPY 553
RDIVQFVPFR++ H S A LAK VLAE+P Q + Y +GIKP + Y
Sbjct: 498 VLRDIVQFVPFRNF-----KH-ASPAALAKSVLAEVPNQVVDYYNGKGIKPKCSSEMY 549
>gi|25141328 copine 7 isoform a [Homo sapiens]
Length = 558
Score = 508 bits (1308), Expect = e-144
Identities = 277/535 (51%), Positives = 367/535 (68%), Gaps = 24/535 (4%)
Query: 23 ATRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFI 82
A++VE+ +SCR+LLDRD +KSDP L Q G +W + GRTEV+ ++L+P F + F
Sbjct: 21 ASKVELRLSCRHLLDRDPLTKSDPSVALLQQAQG--QWVQVGRTEVVRSSLHPVFSKVFT 78
Query: 83 LDYFFEERENLRFDLYDVDSKSP-NLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGK 141
+DY+FEE + LRF++YD S + + DFLG + CTLG+IV + ++ +P++ G+
Sbjct: 79 VDYYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLGQIVAQK--KVTRPLLLKFGR 136
Query: 142 KCG--TIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKT 199
G TI + AE+++ V + F A KLD KD F KSDPFL YR N+D + ++T
Sbjct: 137 NAGKSTITVIAEDISGNNGYVELSFRARKLDDKDLFSKSDPFLELYRVNDDQGLQLVYRT 196
Query: 200 EVVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSR-- 257
EVVKN LNPVW+AFK+S+ +LC+ + R +K V+D+D G HDFIGEF+T++ E+ +
Sbjct: 197 EVVKNNLNPVWEAFKVSLSSLCSCEETRPLKCLVWDYDSRGKHDFIGEFSTTFEEMQKAF 256
Query: 258 --GQSQFNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAID 315
GQ+Q ++ VNPK K K++ Y NSG V L SFLDYI GG QI+FTVAID
Sbjct: 257 EEGQAQ---WDCVNPKYKQKRRSYKNSGVVVLADLKFHRVYSFLDYIMGGCQIHFTVAID 313
Query: 316 FTASNGNPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRI 375
FTASNG+P SLHY+NPYQ N Y AL +VGEI QDYDSDK F ALGFGA++PP +
Sbjct: 314 FTASNGDPRNSCSLHYINPYQPNEYLKALVSVGEICQDYDSDKRFSALGFGARIPPKYEV 373
Query: 376 SHEFALNGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYAS---SVKDG 432
SH+FA+N NP++ C+GI+GV+EAY L VQLYGPTN AP+I+ VAR A+ S
Sbjct: 374 SHDFAINFNPEDDECEGIQGVVEAYQNCLPRVQLYGPTNVAPIISKVARVAAAEESTGKA 433
Query: 433 SQYFVLLIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDD-VRVSS 491
SQY++LLI+TDGV++DMA T+E+IV AS+LPMSIIIVGVG A+F M LDGDD V S
Sbjct: 434 SQYYILLILTDGVVTDMADTREAIVRASRLPMSIIIVGVGNADFTDMQVLDGDDGVLRSP 493
Query: 492 RGKYAERDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKP 546
RG+ A RDIVQFVPFR+ + S A LAK VLAE+P+Q + Y RG+ P
Sbjct: 494 RGEPALRDIVQFVPFRELKN------ASPAALAKCVLAEVPKQVVEYYSHRGLPP 542
>gi|5174421 copine 6 [Homo sapiens]
Length = 557
Score = 494 bits (1271), Expect = e-139
Identities = 272/544 (50%), Positives = 363/544 (66%), Gaps = 20/544 (3%)
Query: 23 ATRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFI 82
A+RVE+ VSC LLDRDT +K P CVL ++ +++W E RTEV+ + +P F R
Sbjct: 19 ASRVELRVSCHGLLDRDTLTKPHP-CVL-LKLYSDEQWVEVERTEVLRSCSSPVFSRVLA 76
Query: 83 LDYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKK 142
L+YFFEE++ L+F ++D + + + FLG CTLG+IV +++ KP++ GK
Sbjct: 77 LEYFFEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQ--TKVTKPLLLKNGKT 134
Query: 143 CG--TIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTE 200
G TI + AEE++ D V + F A KLD KD F KSDPF+ Y++NED S + +TE
Sbjct: 135 AGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTE 194
Query: 201 VVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQS 260
VVKN LNP W+ F++S+ +LC+ D R +K VYD+D G HDFIGEFT++++E+ G +
Sbjct: 195 VVKNNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTA 254
Query: 261 ---QFNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFT 317
Q ++ +NPK + KKK Y +SGTV L VE +FLDYI GG QI+FTVAIDFT
Sbjct: 255 NPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFT 314
Query: 318 ASNGNPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISH 377
ASNG+P SLH ++P Q N Y AL+AVG I QDYDSDK FPA GFGA++PP+ +SH
Sbjct: 315 ASNGDPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSH 374
Query: 378 EFALNGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYA---SSVKDGSQ 434
+FA+N +P+NP C+ I GV+ +Y R L +QLYGPTN AP+IN VA A S ++
Sbjct: 375 DFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATK 434
Query: 435 YFVLLIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRV-SSRG 493
Y VLL++TDGV+SDMA+T+ +IV AS+LPMSIIIVGVG A+F M LDGDD + RG
Sbjct: 435 YSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRG 494
Query: 494 KYAERDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKPSPAPPPY 553
A RDIVQFVPFRD+ D + + LAK VLAE+P Q + Y ++GI P AP P
Sbjct: 495 VPAARDIVQFVPFRDFKD------AAPSALAKCVLAEVPRQVVEYYASQGISPG-APRPC 547
Query: 554 TPPT 557
T T
Sbjct: 548 TLAT 551
>gi|7656993 copine 7 isoform b [Homo sapiens]
Length = 633
Score = 421 bits (1083), Expect = e-118
Identities = 228/427 (53%), Positives = 295/427 (69%), Gaps = 19/427 (4%)
Query: 130 RLEKPIVGIPGKKCG--TIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRS 187
++ +P++ G+ G TI + AE+++ V + F A KLD KD F KSDPFL YR
Sbjct: 200 KVTRPLLLKFGRNAGKSTITVIAEDISGNNGYVELSFRARKLDDKDLFSKSDPFLELYRV 259
Query: 188 NEDGSFTICHKTEVVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGE 247
N+D + ++TEVVKN LNPVW+AFK+S+ +LC+ + R +K V+D+D G HDFIGE
Sbjct: 260 NDDQGLQLVYRTEVVKNNLNPVWEAFKVSLSSLCSCEETRPLKCLVWDYDSRGKHDFIGE 319
Query: 248 FTTSYRELSR----GQSQFNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIK 303
F+T++ E+ + GQ+Q ++ VNPK K K++ Y NSG V L SFLDYI
Sbjct: 320 FSTTFEEMQKAFEEGQAQ---WDCVNPKYKQKRRSYKNSGVVVLADLKFHRVYSFLDYIM 376
Query: 304 GGTQINFTVAIDFTASNGNPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPAL 363
GG QI+FTVAIDFTASNG+P SLHY+NPYQ N Y AL +VGEI QDYDSDK F AL
Sbjct: 377 GGCQIHFTVAIDFTASNGDPRNSCSLHYINPYQPNEYLKALVSVGEICQDYDSDKRFSAL 436
Query: 364 GFGAKLPPDGRISHEFALNGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVA 423
GFGA++PP +SH+FA+N NP++ C+GI+GV+EAY L VQLYGPTN AP+I+ VA
Sbjct: 437 GFGARIPPKYEVSHDFAINFNPEDDECEGIQGVVEAYQNCLPRVQLYGPTNVAPIISKVA 496
Query: 424 RYAS---SVKDGSQYFVLLIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMV 480
R A+ S SQY++LLI+TDGV++DMA T+E+IV AS+LPMSIIIVGVG A+F M
Sbjct: 497 RVAAAEESTGKASQYYILLILTDGVVTDMADTREAIVRASRLPMSIIIVGVGNADFTDMQ 556
Query: 481 ELDGDD-VRVSSRGKYAERDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYM 539
LDGDD V S RG+ A RDIVQFVPFR+ + S A LAK VLAE+P+Q + Y
Sbjct: 557 VLDGDDGVLRSPRGEPALRDIVQFVPFRELKN------ASPAALAKCVLAEVPKQVVEYY 610
Query: 540 RARGIKP 546
RG+ P
Sbjct: 611 SHRGLPP 617
Score = 92.8 bits (229), Expect = 7e-19
Identities = 47/101 (46%), Positives = 69/101 (68%), Gaps = 3/101 (2%)
Query: 23 ATRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFI 82
A++VE+ +SCR+LLDRD +KSDP L Q G +W + GRTEV+ ++L+P F + F
Sbjct: 21 ASKVELRLSCRHLLDRDPLTKSDPSVALLQQAQG--QWVQVGRTEVVRSSLHPVFSKVFT 78
Query: 83 LDYFFEERENLRFDLYDVDSKSP-NLSKHDFLGQVFCTLGE 122
+DY+FEE + LRF++YD S + + DFLG + CTLG+
Sbjct: 79 VDYYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLGQ 119
Score = 47.8 bits (112), Expect = 3e-05
Identities = 38/101 (37%), Positives = 53/101 (52%), Gaps = 8/101 (7%)
Query: 26 VEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDF-VRKFILD 84
VE+S R L D+D FSKSDP LY + ++ + RTEV+ N LNP + K L
Sbjct: 232 VELSFRARKLDDKDLFSKSDPFLELY-RVNDDQGLQLVYRTEVVKNNLNPVWEAFKVSLS 290
Query: 85 YF--FEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEI 123
EE L+ ++D DS+ KHDF+G+ T E+
Sbjct: 291 SLCSCEETRPLKCLVWDYDSR----GKHDFIGEFSTTFEEM 327
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 54.3 bits (129), Expect = 3e-07
Identities = 35/90 (38%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 166 ANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKISVRALCNGDY 225
A L D G SDP++ + + T KT VK TLNPVW + V L GD
Sbjct: 180 ARNLIPMDPNGLSDPYVKLKLIPDPRNLTK-QKTRTVKATLNPVWN--ETFVFNLKPGDV 236
Query: 226 DRTIKVEVYDWDRDGSHDFIGEFTTSYREL 255
+R + VEV+DWDR +DF+G + EL
Sbjct: 237 ERRLSVEVWDWDRTSRNDFMGAMSFGVSEL 266
>gi|39752671 synaptotagmin X [Homo sapiens]
Length = 523
Score = 52.0 bits (123), Expect = 1e-06
Identities = 65/240 (27%), Positives = 97/240 (40%), Gaps = 16/240 (6%)
Query: 30 VSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFILDYFFEE 89
+ +L +D SDP +Y+ K+++ T V TLNP F F +++
Sbjct: 253 IKALDLPAKDFTGTSDPYVKMYLLPDRKKKFQ----TRVHRKTLNPLFDETFQFPVAYDQ 308
Query: 90 REN--LRFDLYDVDSKSPNLSKHDFLGQVFC-TLGEIVG-SQGSRLEKPI--VGIPGKKC 143
N L F +YD D S+HD +G+V L E+ S+ + + K I
Sbjct: 309 LSNRKLHFSVYDFD----RFSRHDMIGEVILDNLFEVSDLSREATVWKDIHCATTESIDL 364
Query: 144 GTIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVK 203
G I+ + L L L D G SDP++ E G KT K
Sbjct: 365 GEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCE-GRRLKKRKTTTKK 423
Query: 204 NTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQFN 263
NTLNPV+ I N D ++ + V D+DR G ++ IG T G+ +N
Sbjct: 424 NTLNPVYNEAIIFDIPPENVD-QVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWN 482
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 50.1 bits (118), Expect = 5e-06
Identities = 31/93 (33%), Positives = 48/93 (51%), Gaps = 5/93 (5%)
Query: 166 ANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVW-QAFKISVRALCNGD 224
A L D G SDP+ V + D KT+ +++TLNP W ++F ++ D
Sbjct: 180 AKNLIPMDPNGLSDPY-VKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKP---SD 235
Query: 225 YDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSR 257
DR + VE++DWDR +DF+G + EL +
Sbjct: 236 KDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMK 268
>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
sapiens]
Length = 778
Score = 50.1 bits (118), Expect = 5e-06
Identities = 66/280 (23%), Positives = 111/280 (39%), Gaps = 60/280 (21%)
Query: 33 RNLLDRDTFSKSDPICVLYVQ-GVGNKEWREFGRTEVIDNTLNPDFVRKFILDYFFEERE 91
R+L D+ SDP YV+ +G+++++ ++++ TLNP + +F + E
Sbjct: 259 RDLKAMDSNGLSDP----YVKFRLGHQKYK----SKIMPKTLNPQWREQFDFHLYEERGG 310
Query: 92 NLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKKCGTIILTAE 151
+ +D D+ + DF+G+ L + Q +LE + G + LTA
Sbjct: 311 VIDITAWDKDAGK----RDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTAS 366
Query: 152 -------------ELNCCRDAVLMQFC--------------------ANKLDKKDFFGKS 178
E R+ +L ++ A L D GKS
Sbjct: 367 ATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKS 426
Query: 179 DPFLVFYRSNEDGSFTICHKTEVVKNTLNPVW-QAFKISVRALCNGDYDRTIKVEVYDWD 237
DPF V +N+ T V LNP W + F +++ D ++V VYD D
Sbjct: 427 DPFCVVELNNDR------LLTHTVYKNLNPEWNKVFTFNIK-----DIHSVLEVTVYDED 475
Query: 238 RDGSHDFIGEFTTSYRELSRGQSQFNVYEVVNPKKKGKKK 277
RD S DF+G+ + G+ + Y + N + G K
Sbjct: 476 RDRSADFLGKVAIPLLSIQNGEQK--AYVLKNKQLTGPTK 513
Score = 30.8 bits (68), Expect = 3.4
Identities = 21/79 (26%), Positives = 40/79 (50%), Gaps = 11/79 (13%)
Query: 169 LDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKISVRALCNGDYDR- 227
L +D G SDP++ F ++ +++++ LNPVW+ +A D+ R
Sbjct: 52 LAARDRGGTSDPYVKFKIGGKE-----VFRSKIIHKNLNPVWEE-----KACILVDHLRE 101
Query: 228 TIKVEVYDWDRDGSHDFIG 246
+ ++V+D+D DF+G
Sbjct: 102 PLYIKVFDYDFGLQDDFMG 120
>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
sapiens]
Length = 999
Score = 50.1 bits (118), Expect = 5e-06
Identities = 66/280 (23%), Positives = 111/280 (39%), Gaps = 60/280 (21%)
Query: 33 RNLLDRDTFSKSDPICVLYVQ-GVGNKEWREFGRTEVIDNTLNPDFVRKFILDYFFEERE 91
R+L D+ SDP YV+ +G+++++ ++++ TLNP + +F + E
Sbjct: 480 RDLKAMDSNGLSDP----YVKFRLGHQKYK----SKIMPKTLNPQWREQFDFHLYEERGG 531
Query: 92 NLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKKCGTIILTAE 151
+ +D D+ + DF+G+ L + Q +LE + G + LTA
Sbjct: 532 VIDITAWDKDAGK----RDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTAS 587
Query: 152 -------------ELNCCRDAVLMQFC--------------------ANKLDKKDFFGKS 178
E R+ +L ++ A L D GKS
Sbjct: 588 ATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKS 647
Query: 179 DPFLVFYRSNEDGSFTICHKTEVVKNTLNPVW-QAFKISVRALCNGDYDRTIKVEVYDWD 237
DPF V +N+ T V LNP W + F +++ D ++V VYD D
Sbjct: 648 DPFCVVELNNDR------LLTHTVYKNLNPEWNKVFTFNIK-----DIHSVLEVTVYDED 696
Query: 238 RDGSHDFIGEFTTSYRELSRGQSQFNVYEVVNPKKKGKKK 277
RD S DF+G+ + G+ + Y + N + G K
Sbjct: 697 RDRSADFLGKVAIPLLSIQNGEQK--AYVLKNKQLTGPTK 734
Score = 30.8 bits (68), Expect = 3.4
Identities = 21/79 (26%), Positives = 40/79 (50%), Gaps = 11/79 (13%)
Query: 169 LDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKISVRALCNGDYDR- 227
L +D G SDP++ F ++ +++++ LNPVW+ +A D+ R
Sbjct: 273 LAARDRGGTSDPYVKFKIGGKE-----VFRSKIIHKNLNPVWEE-----KACILVDHLRE 322
Query: 228 TIKVEVYDWDRDGSHDFIG 246
+ ++V+D+D DF+G
Sbjct: 323 PLYIKVFDYDFGLQDDFMG 341
>gi|28376627 synaptotagmin IX [Homo sapiens]
Length = 491
Score = 48.9 bits (115), Expect = 1e-05
Identities = 59/219 (26%), Positives = 87/219 (39%), Gaps = 16/219 (7%)
Query: 34 NLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFILDYFFEERE-- 91
NL +D SDP +Y+ + + +T+V TLNP F F+ + + E
Sbjct: 246 NLPAKDFSGTSDPYVKIYLL----PDRKTKHQTKVHRKTLNPVFDEVFLFPVPYNDLEAR 301
Query: 92 NLRFDLYDVDSKSPNLSKHDFLGQV----FCTLGEIVGSQGSRLEKPIVGIPGKKCGTII 147
L F +YD D S+HD +GQV F L + + V G ++
Sbjct: 302 KLHFSVYDFD----RFSRHDLIGQVVVDHFLDLADFPRECILWKDIEYVTNDNVDLGELM 357
Query: 148 LTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLN 207
+ L + A L D G SDP+ V DG KT +NTLN
Sbjct: 358 FSLCYLPTAGRLTITIIKARNLKAMDITGASDPY-VKVSLMCDGRRLKKRKTSTKRNTLN 416
Query: 208 PVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIG 246
PV+ + N D + + V D+DR G ++ IG
Sbjct: 417 PVYNEAIVFDVPPENIDQIH-LSIAVMDYDRVGHNEIIG 454
Score = 44.3 bits (103), Expect = 3e-04
Identities = 29/88 (32%), Positives = 46/88 (52%), Gaps = 6/88 (6%)
Query: 166 ANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKISVRALCNGDY 225
A L KDF G SDP++ Y + + H+T+V + TLNPV+ ++ + + D
Sbjct: 244 AVNLPAKDFSGTSDPYVKIYLLPDRKTK---HQTKVHRKTLNPVFD--EVFLFPVPYNDL 298
Query: 226 D-RTIKVEVYDWDRDGSHDFIGEFTTSY 252
+ R + VYD+DR HD IG+ +
Sbjct: 299 EARKLHFSVYDFDRFSRHDLIGQVVVDH 326
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 48.5 bits (114), Expect = 2e-05
Identities = 55/224 (24%), Positives = 94/224 (41%), Gaps = 25/224 (11%)
Query: 39 DTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFILDYFFEER--ENLRFD 96
D SDP +++ K++ T+V TLNP F +F + E + L
Sbjct: 173 DMGGTSDPYVKVFLLPDKKKKFE----TKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMA 228
Query: 97 LYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGK---KCGTIILTAEEL 153
+YD D SKHD +G+ + + + + + + K G I + +
Sbjct: 229 VYDFD----RFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYV 284
Query: 154 NCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVW-QA 212
++ A L K D G SDP++ + ++G KT + KNTLNP + ++
Sbjct: 285 PTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLM-QNGKRLKKKKTTIKKNTLNPYYNES 343
Query: 213 FKISVRALCNGDYDRTIKVEVY----DWDRDGSHDFIGEFTTSY 252
F V +++ KV+V D+D+ G +D IG+ Y
Sbjct: 344 FSFEV------PFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGY 381
Score = 45.1 bits (105), Expect = 2e-04
Identities = 35/116 (30%), Positives = 57/116 (49%), Gaps = 12/116 (10%)
Query: 166 ANKLDKKDFFGKSDPFL-VFYRSNEDGSFTICHKTEVVKNTLNPVWQ---AFKISVRALC 221
A +L D G SDP++ VF ++ F +T+V + TLNPV+ FK+ L
Sbjct: 166 AAELPALDMGGTSDPYVKVFLLPDKKKKF----ETKVHRKTLNPVFNEQFTFKVPYSELG 221
Query: 222 NGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQFNVYEVVNPKKKGKKK 277
+T+ + VYD+DR HD IGEF + G ++ + +K+ ++K
Sbjct: 222 G----KTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEK 273
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 48.5 bits (114), Expect = 2e-05
Identities = 55/224 (24%), Positives = 94/224 (41%), Gaps = 25/224 (11%)
Query: 39 DTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFILDYFFEER--ENLRFD 96
D SDP +++ K++ T+V TLNP F +F + E + L
Sbjct: 173 DMGGTSDPYVKVFLLPDKKKKFE----TKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMA 228
Query: 97 LYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGK---KCGTIILTAEEL 153
+YD D SKHD +G+ + + + + + + K G I + +
Sbjct: 229 VYDFD----RFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYV 284
Query: 154 NCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVW-QA 212
++ A L K D G SDP++ + ++G KT + KNTLNP + ++
Sbjct: 285 PTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLM-QNGKRLKKKKTTIKKNTLNPYYNES 343
Query: 213 FKISVRALCNGDYDRTIKVEVY----DWDRDGSHDFIGEFTTSY 252
F V +++ KV+V D+D+ G +D IG+ Y
Sbjct: 344 FSFEV------PFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGY 381
Score = 45.1 bits (105), Expect = 2e-04
Identities = 35/116 (30%), Positives = 57/116 (49%), Gaps = 12/116 (10%)
Query: 166 ANKLDKKDFFGKSDPFL-VFYRSNEDGSFTICHKTEVVKNTLNPVWQ---AFKISVRALC 221
A +L D G SDP++ VF ++ F +T+V + TLNPV+ FK+ L
Sbjct: 166 AAELPALDMGGTSDPYVKVFLLPDKKKKF----ETKVHRKTLNPVFNEQFTFKVPYSELG 221
Query: 222 NGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQFNVYEVVNPKKKGKKK 277
+T+ + VYD+DR HD IGEF + G ++ + +K+ ++K
Sbjct: 222 G----KTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEK 273
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 48.5 bits (114), Expect = 2e-05
Identities = 55/224 (24%), Positives = 94/224 (41%), Gaps = 25/224 (11%)
Query: 39 DTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFILDYFFEER--ENLRFD 96
D SDP +++ K++ T+V TLNP F +F + E + L
Sbjct: 173 DMGGTSDPYVKVFLLPDKKKKFE----TKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMA 228
Query: 97 LYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGK---KCGTIILTAEEL 153
+YD D SKHD +G+ + + + + + + K G I + +
Sbjct: 229 VYDFD----RFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYV 284
Query: 154 NCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVW-QA 212
++ A L K D G SDP++ + ++G KT + KNTLNP + ++
Sbjct: 285 PTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLM-QNGKRLKKKKTTIKKNTLNPYYNES 343
Query: 213 FKISVRALCNGDYDRTIKVEVY----DWDRDGSHDFIGEFTTSY 252
F V +++ KV+V D+D+ G +D IG+ Y
Sbjct: 344 FSFEV------PFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGY 381
Score = 45.1 bits (105), Expect = 2e-04
Identities = 35/116 (30%), Positives = 57/116 (49%), Gaps = 12/116 (10%)
Query: 166 ANKLDKKDFFGKSDPFL-VFYRSNEDGSFTICHKTEVVKNTLNPVWQ---AFKISVRALC 221
A +L D G SDP++ VF ++ F +T+V + TLNPV+ FK+ L
Sbjct: 166 AAELPALDMGGTSDPYVKVFLLPDKKKKF----ETKVHRKTLNPVFNEQFTFKVPYSELG 221
Query: 222 NGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQFNVYEVVNPKKKGKKK 277
+T+ + VYD+DR HD IGEF + G ++ + +K+ ++K
Sbjct: 222 G----KTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEK 273
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 48.1 bits (113), Expect = 2e-05
Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 5/93 (5%)
Query: 166 ANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVW-QAFKISVRALCNGD 224
A L D G SDP+ V + D KT+ +K +LNP W + F+ ++ D
Sbjct: 180 AKNLVPMDPNGLSDPY-VKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK---ESD 235
Query: 225 YDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSR 257
DR + VE++DWD +DF+G + EL +
Sbjct: 236 KDRRLSVEIWDWDLTSRNDFMGSLSFGISELQK 268
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 48.1 bits (113), Expect = 2e-05
Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 5/93 (5%)
Query: 166 ANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVW-QAFKISVRALCNGD 224
A L D G SDP+ V + D KT+ +K +LNP W + F+ ++ D
Sbjct: 180 AKNLVPMDPNGLSDPY-VKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK---ESD 235
Query: 225 YDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSR 257
DR + VE++DWD +DF+G + EL +
Sbjct: 236 KDRRLSVEIWDWDLTSRNDFMGSLSFGISELQK 268
>gi|92859638 synaptotagmin V [Homo sapiens]
Length = 386
Score = 47.8 bits (112), Expect = 3e-05
Identities = 53/214 (24%), Positives = 90/214 (42%), Gaps = 17/214 (7%)
Query: 39 DTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFILDYFFEEREN--LRFD 96
D SDP +Y+ + + T+V TLNP F F + E L
Sbjct: 139 DLGGSSDPYVRVYLLPDKRRRYE----TKVHRQTLNPHFGETFAFKVPYVELGGRVLVMA 194
Query: 97 LYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGK---KCGTIILTAEEL 153
+YD D S++D +G+V + + + + + + P + K G I + +
Sbjct: 195 VYDFD----RFSRNDAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQEKLGDICFSLRYV 250
Query: 154 NCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVW-QA 212
++ A L K D G SDP++ + + G KT + KNTLNP + +A
Sbjct: 251 PTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLL-QGGKKVRKKKTTIKKNTLNPYYNEA 309
Query: 213 FKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIG 246
F V C+ +++ V D+D+ G ++ IG
Sbjct: 310 FSFEVP--CDQVQKVQVELTVLDYDKLGKNEAIG 341
Score = 32.7 bits (73), Expect = 0.91
Identities = 27/90 (30%), Positives = 42/90 (46%), Gaps = 10/90 (11%)
Query: 173 DFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQ---AFKISVRALCNGDYDRTI 229
D G SDP++ Y + ++T+V + TLNP + AFK+ L R +
Sbjct: 139 DLGGSSDPYVRVYLLPDKRRR---YETKVHRQTLNPHFGETFAFKVPYVELGG----RVL 191
Query: 230 KVEVYDWDRDGSHDFIGEFTTSYRELSRGQ 259
+ VYD+DR +D IGE + G+
Sbjct: 192 VMAVYDFDRFSRNDAIGEVRVPMSSVDLGR 221
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 47.0 bits (110), Expect = 5e-05
Identities = 60/218 (27%), Positives = 93/218 (42%), Gaps = 22/218 (10%)
Query: 38 RDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFILDYFFEE--RENLRF 95
+D+ SDP +Y+ K+++ T+V TLNP F F E + L F
Sbjct: 329 KDSNGFSDPYVKIYLLPDRKKKFQ----TKVHRKTLNPVFNETFQFSVPLAELAQRKLHF 384
Query: 96 DLYDVDSKSPNLSKHDFLGQVFC-TLGEIVGSQGSR-LEKPIVGIPGKKC--GTIILTAE 151
+YD D S+HD +GQV L E+ R L + IV +K G + +
Sbjct: 385 SVYDFD----RFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADLGELNFSLC 440
Query: 152 ELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQ 211
L + A+ L D G SDP++ +E G KT + KNTLNP +
Sbjct: 441 YLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISE-GRRLKKRKTSIKKNTLNPTYN 499
Query: 212 ---AFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIG 246
F ++ ++ N + + V D+D G ++ IG
Sbjct: 500 EALVFDVAPESVENVG----LSIAVVDYDCIGHNEVIG 533
Score = 40.8 bits (94), Expect = 0.003
Identities = 34/111 (30%), Positives = 47/111 (42%), Gaps = 10/111 (9%)
Query: 140 GKKCGTIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKT 199
G CG I L V+ A L KD G SDP++ Y + +T
Sbjct: 297 GAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKK---FQT 353
Query: 200 EVVKNTLNPVWQA---FKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGE 247
+V + TLNPV+ F + + L R + VYD+DR HD IG+
Sbjct: 354 KVHRKTLNPVFNETFQFSVPLAELAQ----RKLHFSVYDFDRFSRHDLIGQ 400
Score = 31.2 bits (69), Expect = 2.6
Identities = 30/97 (30%), Positives = 43/97 (44%), Gaps = 8/97 (8%)
Query: 9 AGIGDLNQLSAAIP-ATRVEVSV-SCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGR- 65
A +G+LN +P A R+ V++ NL D SDP YV+ E R +
Sbjct: 430 ADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDP----YVKASLISEGRRLKKR 485
Query: 66 -TEVIDNTLNPDFVRKFILDYFFEERENLRFDLYDVD 101
T + NTLNP + + D E EN+ + VD
Sbjct: 486 KTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVD 522
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,355,707
Number of Sequences: 37866
Number of extensions: 946710
Number of successful extensions: 3910
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 3498
Number of HSP's gapped (non-prelim): 299
length of query: 564
length of database: 18,247,518
effective HSP length: 108
effective length of query: 456
effective length of database: 14,157,990
effective search space: 6456043440
effective search space used: 6456043440
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.