Search of human proteins with 242332545

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|242332545 coiled-coil domain containing 121-like [Homo
sapiens]
         (439 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|242332545 coiled-coil domain containing 121-like [Homo sapiens]    841   0.0  
gi|218083720 coiled-coil domain containing 121 isoform 2 [Homo s...    69   6e-12
gi|218083716 coiled-coil domain containing 121 isoform 1 [Homo s...    69   6e-12
gi|39979626 coiled-coil domain containing 121 isoform 3 [Homo sa...    69   6e-12
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa...    59   9e-09
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap...    59   9e-09
gi|166295204 hypothetical protein LOC80127 [Homo sapiens]              55   2e-07
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa...    53   5e-07
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa...    53   5e-07
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...    52   8e-07
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...    52   1e-06
gi|148746195 trichohyalin [Homo sapiens]                               52   1e-06
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]        51   2e-06
gi|88196790 coiled-coil domain containing 88 [Homo sapiens]            50   3e-06
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap...    49   7e-06
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C...    49   7e-06
gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo sapi...    49   9e-06
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        49   1e-05
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        49   1e-05
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         49   1e-05
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         49   1e-05
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         49   1e-05
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         49   1e-05
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         49   1e-05
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         49   1e-05
gi|239752594 PREDICTED: hypothetical protein, partial [Homo sapi...    48   2e-05
gi|148762940 DVL-binding protein DAPLE [Homo sapiens]                  48   2e-05
gi|171906567 peripheral benzodiazepine receptor-associated prote...    48   2e-05
gi|171906559 peripheral benzodiazepine receptor-associated prote...    48   2e-05
gi|16262452 cingulin [Homo sapiens]                                    47   3e-05

>gi|242332545 coiled-coil domain containing 121-like [Homo sapiens]
          Length = 439

 Score =  841 bits (2173), Expect = 0.0
 Identities = 439/439 (100%), Positives = 439/439 (100%)

Query: 1   MAPKKKRGPSAGSQPGGAAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENA 60
           MAPKKKRGPSAGSQPGGAAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENA
Sbjct: 1   MAPKKKRGPSAGSQPGGAAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENA 60

Query: 61  FLDREALRLREENRLYASYVSARAQRCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGRE 120
           FLDREALRLREENRLYASYVSARAQRCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGRE
Sbjct: 61  FLDREALRLREENRLYASYVSARAQRCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGRE 120

Query: 121 DGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVK 180
           DGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVK
Sbjct: 121 DGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVK 180

Query: 181 RRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRTQL 240
           RRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRTQL
Sbjct: 181 RRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRTQL 240

Query: 241 LHHTRRQLLEQREQLHREHEDTRDLARVHGWLRRGPGGPPLWERPAFSQPTSRPGSLAAP 300
           LHHTRRQLLEQREQLHREHEDTRDLARVHGWLRRGPGGPPLWERPAFSQPTSRPGSLAAP
Sbjct: 241 LHHTRRQLLEQREQLHREHEDTRDLARVHGWLRRGPGGPPLWERPAFSQPTSRPGSLAAP 300

Query: 301 ISPSRAASQTPSVVPSRAAPRASSVVPSREASRVPSLVLSSMDSRVPSLATSKVGSRMPS 360
           ISPSRAASQTPSVVPSRAAPRASSVVPSREASRVPSLVLSSMDSRVPSLATSKVGSRMPS
Sbjct: 301 ISPSRAASQTPSVVPSRAAPRASSVVPSREASRVPSLVLSSMDSRVPSLATSKVGSRMPS 360

Query: 361 LTASRAGSRALSLVQSLEGSGISSGSSPRVSSQDTLRSTKSGPKLLSGLSRDRDPALLPP 420
           LTASRAGSRALSLVQSLEGSGISSGSSPRVSSQDTLRSTKSGPKLLSGLSRDRDPALLPP
Sbjct: 361 LTASRAGSRALSLVQSLEGSGISSGSSPRVSSQDTLRSTKSGPKLLSGLSRDRDPALLPP 420

Query: 421 QSEDSVNAEAAAEASPGRA 439
           QSEDSVNAEAAAEASPGRA
Sbjct: 421 QSEDSVNAEAAAEASPGRA 439


>gi|218083720 coiled-coil domain containing 121 isoform 2 [Homo
           sapiens]
          Length = 440

 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 51/230 (22%), Positives = 110/230 (47%), Gaps = 12/230 (5%)

Query: 41  LSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVRLDEQNRV 100
           L++ +   +    Q+L E+  L RE L ++ ENR +  Y++ + +   +   ++      
Sbjct: 166 LNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQ 225

Query: 101 DLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRA 160
              +I  +R E AS Y  +   ++  LL+ E   + + +++Q ++   +L+ +Q   I+ 
Sbjct: 226 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 285

Query: 161 LERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQRVQSL-ARRAERE----------- 208
           L+ E   ++ E       V+ + L++K   E++  +  + L  +R  RE           
Sbjct: 286 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLA 345

Query: 209 AVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHRE 258
           A R +  ++  I  +N + ++ELL L+ + Q L  T+  L  +++QL +E
Sbjct: 346 AKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 395


>gi|218083716 coiled-coil domain containing 121 isoform 1 [Homo
           sapiens]
          Length = 442

 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 51/230 (22%), Positives = 110/230 (47%), Gaps = 12/230 (5%)

Query: 41  LSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVRLDEQNRV 100
           L++ +   +    Q+L E+  L RE L ++ ENR +  Y++ + +   +   ++      
Sbjct: 168 LNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQ 227

Query: 101 DLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRA 160
              +I  +R E AS Y  +   ++  LL+ E   + + +++Q ++   +L+ +Q   I+ 
Sbjct: 228 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 287

Query: 161 LERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQRVQSL-ARRAERE----------- 208
           L+ E   ++ E       V+ + L++K   E++  +  + L  +R  RE           
Sbjct: 288 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLA 347

Query: 209 AVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHRE 258
           A R +  ++  I  +N + ++ELL L+ + Q L  T+  L  +++QL +E
Sbjct: 348 AKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 397


>gi|39979626 coiled-coil domain containing 121 isoform 3 [Homo
           sapiens]
          Length = 278

 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 51/230 (22%), Positives = 110/230 (47%), Gaps = 12/230 (5%)

Query: 41  LSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVRLDEQNRV 100
           L++ +   +    Q+L E+  L RE L ++ ENR +  Y++ + +   +   ++      
Sbjct: 4   LNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQ 63

Query: 101 DLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRA 160
              +I  +R E AS Y  +   ++  LL+ E   + + +++Q ++   +L+ +Q   I+ 
Sbjct: 64  KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 123

Query: 161 LERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQRVQSL-ARRAERE----------- 208
           L+ E   ++ E       V+ + L++K   E++  +  + L  +R  RE           
Sbjct: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLA 183

Query: 209 AVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHRE 258
           A R +  ++  I  +N + ++ELL L+ + Q L  T+  L  +++QL +E
Sbjct: 184 AKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 233


>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
           sapiens]
          Length = 1352

 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 91/349 (26%), Positives = 144/349 (41%), Gaps = 39/349 (11%)

Query: 119 REDGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR 178
           R D +R QL   E   A   QQ+++ Q        QL   R   ++ +  + E  + L  
Sbjct: 351 RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAER---QKRIEEQKEQRRRLEE 407

Query: 179 VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAI---KADNGRLRQELL--- 232
            +RR  E +   ERE R+  +   RR E    R    H Q     + +  + + E+L   
Sbjct: 408 QQRREKELRKQQEREQRRHYEEQMRREEE---RRRAEHEQEYIRRQLEEEQRQLEILQQQ 464

Query: 233 LLLRRTQLLHHTRRQLLEQR--EQLHREHEDTRD--LARVHGWLRRGP-GGPPLWERPAF 287
           LL  +  LL + R+QL EQR  E+L R+ +  RD  ++  H    + P    PL+     
Sbjct: 465 LLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEG 524

Query: 288 SQPTSRPGSLAAPISPSRAASQTPSVVPSRAAPRASSV-VPSREAS---------RVPSL 337
             P+ +P         SR   Q+   +P + A R S   +P R  S         R P +
Sbjct: 525 MSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPM 584

Query: 338 VLSSMDSRVPSLATSKVGSRMPSLTASRA----GSRALSLVQSLEGSGISSGSSPRVSSQ 393
            L  +D ++P L   K  S+ P+LTAS++     ++ LS  Q            PR +S 
Sbjct: 585 -LRPVDPQIPHLVAVK--SQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSD 641

Query: 394 DTLRSTKSGPKL-----LSGLSRDRDPALLPPQSEDSVNAEAAAEASPG 437
            T  +     ++      S L ++ D     PQ   S++   A + SPG
Sbjct: 642 PTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPG 690


>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
           sapiens]
          Length = 1360

 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 91/349 (26%), Positives = 144/349 (41%), Gaps = 39/349 (11%)

Query: 119 REDGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR 178
           R D +R QL   E   A   QQ+++ Q        QL   R   ++ +  + E  + L  
Sbjct: 351 RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAER---QKRIEEQKEQRRRLEE 407

Query: 179 VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAI---KADNGRLRQELL--- 232
            +RR  E +   ERE R+  +   RR E    R    H Q     + +  + + E+L   
Sbjct: 408 QQRREKELRKQQEREQRRHYEEQMRREEE---RRRAEHEQEYIRRQLEEEQRQLEILQQQ 464

Query: 233 LLLRRTQLLHHTRRQLLEQR--EQLHREHEDTRD--LARVHGWLRRGP-GGPPLWERPAF 287
           LL  +  LL + R+QL EQR  E+L R+ +  RD  ++  H    + P    PL+     
Sbjct: 465 LLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEG 524

Query: 288 SQPTSRPGSLAAPISPSRAASQTPSVVPSRAAPRASSV-VPSREAS---------RVPSL 337
             P+ +P         SR   Q+   +P + A R S   +P R  S         R P +
Sbjct: 525 MSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPM 584

Query: 338 VLSSMDSRVPSLATSKVGSRMPSLTASRA----GSRALSLVQSLEGSGISSGSSPRVSSQ 393
            L  +D ++P L   K  S+ P+LTAS++     ++ LS  Q            PR +S 
Sbjct: 585 -LRPVDPQIPHLVAVK--SQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSD 641

Query: 394 DTLRSTKSGPKL-----LSGLSRDRDPALLPPQSEDSVNAEAAAEASPG 437
            T  +     ++      S L ++ D     PQ   S++   A + SPG
Sbjct: 642 PTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPG 690


>gi|166295204 hypothetical protein LOC80127 [Homo sapiens]
          Length = 529

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 40/204 (19%), Positives = 91/204 (44%)

Query: 57  RENAFLDREALRLREENRLYASYVSARAQRCAKAIVRLDEQNRVDLAQIHWQRAELASLY 116
           + N  L ++  ++ ++     SY+  + Q     I +L +Q      +   ++ +L   Y
Sbjct: 62  KSNEDLKKKQCKMEKDIMSVLSYLKKQDQEKDNMIEKLKQQLNETKEKAQEEKDKLEQKY 121

Query: 117 HGREDGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLL 176
             + + +  Q  +       +  +++ ++ ++  +++    +  L+  L +    H + L
Sbjct: 122 TRQINELEGQFHQKAKEIGMIHTELKAVRQFQKRKIQVERELDDLKENLRNTERIHQETL 181

Query: 177 HRVKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLR 236
            R++ RF E+K   E+EA +++  LA RA  EA+  L    + +  +N  L++ L   L+
Sbjct: 182 RRLESRFFEEKHRLEQEAEKKIIMLAERAHHEAIVQLNDAGRNVFKENDYLQKALAYHLK 241

Query: 237 RTQLLHHTRRQLLEQREQLHREHE 260
            T  L    ++L E    L  + E
Sbjct: 242 ETDALQKNSQKLQESHTLLLHQKE 265


>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
           sapiens]
          Length = 1323

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 79/336 (23%), Positives = 132/336 (39%), Gaps = 42/336 (12%)

Query: 119 REDGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR 178
           R D +R QL   E   A   QQ+++ Q        QL   R   ++ +  + E  + L  
Sbjct: 351 RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAER---QKRIEEQKEQRRRLEE 407

Query: 179 VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRT 238
            +RR  E +   ERE R+  +   RR E    R    H Q  K             L   
Sbjct: 408 QQRREKELRKQQEREQRRHYEEQMRREEE---RRRAEHEQEYKRKQ----------LEEQ 454

Query: 239 QLLHHTRRQLLEQRE---QLHREHEDTRDLAR---VHGWLRRGPGGPPLWERPAFSQPTS 292
           +     +RQL ++R+    L  + ++ R + +    H      P   P W +    +  S
Sbjct: 455 RQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEV--EERS 512

Query: 293 RPGSLAAPISPSRAASQ--TPSVVPSRAAPRASSVVPSREASRVPSLVLSSMDSRVPSLA 350
           R    ++P  P + A++   P++ P   +   S V P+R        +L  +D ++P L 
Sbjct: 513 RLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPP-----MLRPVDPQIPHLV 567

Query: 351 TSKVGSRMPSLTASRA----GSRALSLVQSLEGSGISSGSSPRVSSQDTLRSTKSGPKL- 405
             K  S+ P+LTAS++     ++ LS  Q            PR +S  T  +     ++ 
Sbjct: 568 AVK--SQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIE 625

Query: 406 ----LSGLSRDRDPALLPPQSEDSVNAEAAAEASPG 437
                S L ++ D     PQ   S++   A + SPG
Sbjct: 626 KFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPG 661


>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
           sapiens]
          Length = 1331

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 79/336 (23%), Positives = 132/336 (39%), Gaps = 42/336 (12%)

Query: 119 REDGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR 178
           R D +R QL   E   A   QQ+++ Q        QL   R   ++ +  + E  + L  
Sbjct: 351 RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAER---QKRIEEQKEQRRRLEE 407

Query: 179 VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRT 238
            +RR  E +   ERE R+  +   RR E    R    H Q  K             L   
Sbjct: 408 QQRREKELRKQQEREQRRHYEEQMRREEE---RRRAEHEQEYKRKQ----------LEEQ 454

Query: 239 QLLHHTRRQLLEQRE---QLHREHEDTRDLAR---VHGWLRRGPGGPPLWERPAFSQPTS 292
           +     +RQL ++R+    L  + ++ R + +    H      P   P W +    +  S
Sbjct: 455 RQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEV--EERS 512

Query: 293 RPGSLAAPISPSRAASQ--TPSVVPSRAAPRASSVVPSREASRVPSLVLSSMDSRVPSLA 350
           R    ++P  P + A++   P++ P   +   S V P+R        +L  +D ++P L 
Sbjct: 513 RLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPP-----MLRPVDPQIPHLV 567

Query: 351 TSKVGSRMPSLTASRA----GSRALSLVQSLEGSGISSGSSPRVSSQDTLRSTKSGPKL- 405
             K  S+ P+LTAS++     ++ LS  Q            PR +S  T  +     ++ 
Sbjct: 568 AVK--SQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIE 625

Query: 406 ----LSGLSRDRDPALLPPQSEDSVNAEAAAEASPG 437
                S L ++ D     PQ   S++   A + SPG
Sbjct: 626 KFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPG 661


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score = 52.4 bits (124), Expect = 8e-07
 Identities = 88/331 (26%), Positives = 134/331 (40%), Gaps = 58/331 (17%)

Query: 120 EDGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRV 179
           E  +R   L ++    + ++ ++  Q   +LQ +QL      +R+LL  R +  +   + 
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQ---LLQEQQLREQEEYKRQLLAERQKRIEQ-QKE 404

Query: 180 KRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLR-QELLLLLRRT 238
           +RR LE++   EREAR++ +   RR E+E  R L    +  K +  R R +E    + R 
Sbjct: 405 QRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVERE 464

Query: 239 QLLHHTRRQLLE--------QREQLHREHEDTRDLARVHGWLRRGPGGPPLWER--PAFS 288
           Q   + RRQL E        Q++ L  +     D  R H    + P  PP  ER  P+F 
Sbjct: 465 Q--EYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQP-PPPQQERSKPSFH 521

Query: 289 QP------------------------------TSRPGSLAAPISPSRAAS----QTPSVV 314
            P                              + + G +  P  PSR+ S     + SV 
Sbjct: 522 APEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVH 581

Query: 315 PSRAAPRASSVVPSREASRVPSLVLSSMDSRVPSLATSKVGSRMPSLTASRAGSRALSLV 374
           P+   P A   VP R  SR P  VLS  DS +         +   + T+S         V
Sbjct: 582 PALQRP-AEPQVPVRTTSRSP--VLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERV 638

Query: 375 QSL---EGSGISSGSSPRVSSQDTLRSTKSG 402
           + L    GSG SSGSS   S   +   ++SG
Sbjct: 639 EKLVPRPGSGSSSGSSNSGSQPGSHPGSQSG 669


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 85/322 (26%), Positives = 136/322 (42%), Gaps = 39/322 (12%)

Query: 120 EDGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRV 179
           E  +R   L ++    + ++ ++  Q   +LQ +QL      +R+LL  R +  +   + 
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQ---LLQEQQLREQEEYKRQLLAERQKRIEQ-QKE 404

Query: 180 KRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLR-QELLLLLRRT 238
           +RR LE++   EREAR++ +   RR E+E  R L    +  K +  R R +E    + R 
Sbjct: 405 QRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVERE 464

Query: 239 QLLHHTRRQLLE--------QREQLHREHEDTRDLARVHGWLRRGPGGPPLWER--PAFS 288
           Q   + RRQL E        Q++ L  +     D  R H    + P  PP  ER  P+F 
Sbjct: 465 Q--EYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQP-PPPQQERSKPSFH 521

Query: 289 QPTSR----PGSLAAPISPSRAASQTPSVVPSRAAPRASSVVPSREASRVPSLVLSSMDS 344
            P  +    P   A  + P R  S++P V+  R +P   S   + +A +      +S  S
Sbjct: 522 APEPKAHYEPADRAREV-PVRTTSRSP-VLSRRDSPLQGSGQQNSQAGQ-----RNSTSS 574

Query: 345 RVPSLATSKVGSRMP------SLTASRAGSRALSLVQSLEGSG----ISSGSSPRVSSQD 394
             P L   +V   +P      S  +S +GS+  S   S  GSG    + S S    S   
Sbjct: 575 IEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQ 634

Query: 395 TLRSTKSGPKLLSGLSRDRDPA 416
            L +    P+    + R   PA
Sbjct: 635 RLENAVKKPEDKKEVFRPLKPA 656



 Score = 37.4 bits (85), Expect = 0.027
 Identities = 70/310 (22%), Positives = 112/310 (36%), Gaps = 21/310 (6%)

Query: 9   PSAGSQPGGAAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALR 68
           P    +P        E  L      LQ+E+   SE L   +   +Q LRE     R+ L 
Sbjct: 334 PEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLA 393

Query: 69  LREENRLYASYVSARAQRCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLL 128
            R++          R ++  +   RL+EQ R +      Q  E       RE   + +L 
Sbjct: 394 ERQK----------RIEQQKEQRRRLEEQQRREREARRQQERE----QRRREQEEKRRLE 439

Query: 129 EMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKA 188
           E+E R  +  ++ +  +  + ++ EQ    R LE E  H+ V   QLL   +   L D  
Sbjct: 440 ELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQE-QAMLLHDHR 498

Query: 189 AFEREARQRVQSLARRAEREAVRALVAHTQAIKADNG-----RLRQELLLLLRRTQLLHH 243
               +  Q+     +   + +  A         AD       R      +L RR   L  
Sbjct: 499 RPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTSRSPVLSRRDSPLQG 558

Query: 244 TRRQLLEQREQLHREHEDTRDL-ARVHGWLRRGPGGPPLWERPAFSQPTSRPGSLAAPIS 302
           + +Q  +  ++      + R L  RV   + R   G       + SQP S PGS +    
Sbjct: 559 SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGE 618

Query: 303 PSRAASQTPS 312
             R  S + S
Sbjct: 619 RFRVRSSSKS 628


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 64/246 (26%), Positives = 108/246 (43%), Gaps = 13/246 (5%)

Query: 24  EQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSAR 83
           EQ L    +  +RE  L  EQ    EE  +Q LR    L RE  +LR E +L       R
Sbjct: 348 EQQLRREQEEERREQQLRREQE---EERREQQLRREQQLRREQ-QLRREQQLRREQQLRR 403

Query: 84  AQRCAK-AIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQ 142
            Q+  +   +R ++Q R +      Q  E     H +E   +    E E R   + ++ +
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE 463

Query: 143 ELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQRVQSLA 202
             +  +  + +QL R +  ER    +++E  +   + +RR  E +   E+E R R Q L 
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR--EQQLRREQEER-REQRLK 520

Query: 203 RRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLL-----EQREQLHR 257
           R+ E E ++  +   Q ++ +    R++LL      +L    R Q L     E+R+QL +
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580

Query: 258 EHEDTR 263
             E+ R
Sbjct: 581 REEERR 586



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 63/241 (26%), Positives = 95/241 (39%), Gaps = 16/241 (6%)

Query: 25  QPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARA 84
           Q   ++ Q L+RE  L  +Q +   E  ++  R      RE    R E +L       R 
Sbjct: 291 QEEEQQQQRLRREQQLRRKQEEERREQQEE--RREQQERREQQEERREQQLRREQEERRE 348

Query: 85  QRCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQEL 144
           Q+    + R  E+ R +      Q  E       RE  +R    E + R  Q  ++ Q+L
Sbjct: 349 QQ----LRREQEEERREQQLRREQEEERREQQLRREQQLRR---EQQLRREQQLRREQQL 401

Query: 145 QPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQRVQSLARR 204
           +  + L+ EQ  R     R    +R E  +  H  K      +   +RE  +R   L R 
Sbjct: 402 RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKRE 461

Query: 205 AEREAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQRE-QLHREHEDTR 263
            E E         Q +K D    R+E  L L   +     RR+  E+RE QL RE E+ R
Sbjct: 462 EETER-HEQERRKQQLKRDQEEERRERWLKLEEEE-----RREQQERREQQLRREQEERR 515

Query: 264 D 264
           +
Sbjct: 516 E 516



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 62/258 (24%), Positives = 105/258 (40%), Gaps = 36/258 (13%)

Query: 24   EQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSAR 83
            E+P   R Q L+R++     + +  ++  +Q+LRE      +  R +E  R Y      +
Sbjct: 1156 EEPEKRRRQELERQY----REEEELQQEEEQLLREE-----QEKRRQERERQYREEEELQ 1206

Query: 84   AQRCAKAIVRLDEQNRVDLAQIHWQRAELASLYH------GREDGVRAQLLEMEARAAQM 137
             Q+  +     DE  R DL +  W+  +  ++        GRE+    QL + + R  Q 
Sbjct: 1207 RQKRKQRY--RDEDQRSDL-KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQS 1263

Query: 138  AQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQR 197
             Q +Q L        EQ  R R  ER     R  H     +++R   E K A  R+ + +
Sbjct: 1264 QQDLQHLLG------EQQERDREQERRRWQQRDRHFPEEEQLERE--EQKEAKRRDRKSQ 1315

Query: 198  VQSLARRAEREAVRALVAHTQAIKADNGRL---------RQELLLLLRRTQLLHHTR-RQ 247
             +    R ERE  R      +  + +   L         RQE     R  +L H  + R+
Sbjct: 1316 EEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375

Query: 248  LLEQREQLHREHEDTRDL 265
             LE+ ++L R+  + + L
Sbjct: 1376 FLEEEQRLRRQERERKFL 1393



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 69/276 (25%), Positives = 112/276 (40%), Gaps = 49/276 (17%)

Query: 24  EQPLSERAQYLQREHALLSE-QLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSA 82
           E+   +R ++ +RE     E QL +C+    +      F D E LR RE   L       
Sbjct: 171 EELWRQRQEWQEREERRAEEEQLQSCKGHETE-----EFPDEEQLRRRELLEL------R 219

Query: 83  RAQRCAKAIVRLDEQNRV--DLAQIHWQRAELASLYHGREDGVRA--------------Q 126
           R  R  K   R + Q+RV  +  +  W++ E  ++    E+ ++               Q
Sbjct: 220 RKGREEKQQQRRERQDRVFQEEEEKEWRKRE--TVLRKEEEKLQEEEPQRQRELQEEEEQ 277

Query: 127 LLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALER-ELLHMRVEHT-----------Q 174
           L ++E +  +  +Q +E Q  ++ + +QL R +  ER E    R E             Q
Sbjct: 278 LRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQ 337

Query: 175 LLHRVKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELL-- 232
            L R +    E +   E+E  +R Q L R  E E     +   Q ++ +    R++ L  
Sbjct: 338 QLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRR 397

Query: 233 -LLLRRTQLLHH----TRRQLLEQREQLHREHEDTR 263
              LRR Q L       R Q L + +QL RE E+ R
Sbjct: 398 EQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 66/263 (25%), Positives = 108/263 (41%), Gaps = 28/263 (10%)

Query: 24  EQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLR------------E 71
           EQ L  R Q L+RE  L  EQ +   E   +  R    L RE    R            E
Sbjct: 410 EQQL-RREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHE 468

Query: 72  ENRLYASYVSARAQRCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQ----L 127
           + R        + +   +  ++L+E+ R +  +   Q+         RE  ++ Q     
Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ-EERREQRLKRQEEEER 527

Query: 128 LEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDK 187
           L+   R+ Q  ++ QE +  ++L+ E+  R+    RE    R +  +    +KR     +
Sbjct: 528 LQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQ 587

Query: 188 AAFEREARQRVQSLARRAEREAVRALVAHTQAIKAD--NGRLRQELLLL----LRRTQLL 241
              +RE  +R++   +R E E +       Q +K +      RQ+LL       RR Q L
Sbjct: 588 QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL 647

Query: 242 HHTRRQLLEQREQ-LHREHEDTR 263
              RR+  E+REQ L RE E+ R
Sbjct: 648 ---RREQQERREQRLKREEEEER 667



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 66/262 (25%), Positives = 108/262 (41%), Gaps = 21/262 (8%)

Query: 24  EQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRL------REENRLYA 77
           E+P   R Q  Q +   L+E  +  E+      R+    D E  R       REE R   
Sbjct: 131 EEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEE 190

Query: 78  SYVSARAQRCAKAIVRLDEQNRVDLAQIHWQ-RAELASLYHGREDGVRAQLLEMEARAAQ 136
             + +      +     ++  R +L ++  + R E       R+D V  +  E E R  +
Sbjct: 191 EQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRE 250

Query: 137 MA-----QQVQELQPYKVLQL-EQLARIRALER-ELLHMRVEHTQLLHRVKR-RFLEDKA 188
                  +++QE +P +  +L E+  ++R LER EL   R E  Q   R++R + L  K 
Sbjct: 251 TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ 310

Query: 189 AFEREARQ--RVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRTQLL----H 242
             ER  +Q  R +   RR ++E  R      +  +    +LR+E     R  QL      
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370

Query: 243 HTRRQLLEQREQLHREHEDTRD 264
             R Q L + +QL RE +  R+
Sbjct: 371 ERREQQLRREQQLRREQQLRRE 392



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 54/248 (21%), Positives = 106/248 (42%), Gaps = 24/248 (9%)

Query: 32   QYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAI 91
            + L+RE    +++ D   +   Q+LRE    +RE  R R+E            Q   +  
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLRE----EREEKRRRQETDRKFREEEQLLQEREEQP 1352

Query: 92   VRLDEQNRVDLAQIHWQRAELASLYHGR---EDGVRAQLLEMEARAAQMAQQVQELQPYK 148
            +R  E++R       ++  EL     GR   E+  R +  E E +  +  QQ++  +  +
Sbjct: 1353 LRRQERDR------KFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQ 1406

Query: 149  VLQLEQLARIRALERELLHM------RVEHTQLLHRVK-RRFLEDKAAFEREARQRV--- 198
             L+ ++  + R  E++L         R E  Q+  + + R+FLE++    +E  ++    
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466

Query: 199  QSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRTQLL-HHTRRQLLEQREQLHR 257
            + L +  E + +       + ++ +    RQE     R  +L      R+ LE+ +QLHR
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR 1526

Query: 258  EHEDTRDL 265
            +    + L
Sbjct: 1527 QQRQRKFL 1534



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 59/246 (23%), Positives = 96/246 (39%), Gaps = 34/246 (13%)

Query: 24   EQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSAR 83
            EQPL  +    +R+     E+L   E+          FL+ E  RLR + R        +
Sbjct: 1350 EQPLRRQ----ERDRKFREEELRHQEQG-------RKFLEEEQ-RLRRQERERKFLKEEQ 1397

Query: 84   AQRCAKAI--VRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQV 141
              RC +    +R D   +    +    R E    +   E  VR Q  E E +  +  QQ+
Sbjct: 1398 QLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ--ERERKFLEEEQQL 1455

Query: 142  QELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKR--RFLEDKAAFEREARQRVQ 199
            ++ +  K  + EQL +    ERE         Q LHR +R  +FLE++    R+ R R  
Sbjct: 1456 RQERHRKFREEEQLLQ----ERE--------EQQLHRQERDRKFLEEEQQLRRQERDRKF 1503

Query: 200  SLARRAEREAVRALVAHTQAIKADNGRLR----QELLLLLRRTQLLHHTRRQLLEQREQL 255
                   +E  R  +   Q +     + +    ++ L    R Q     R +   + EQL
Sbjct: 1504 REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL 1563

Query: 256  HREHED 261
             +E E+
Sbjct: 1564 RQEREE 1569



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 57/245 (23%), Positives = 103/245 (42%), Gaps = 22/245 (8%)

Query: 27   LSERAQYLQREHALLSEQLDTCEESVDQVL----RENAFLDREA-LRLREENRLYASYVS 81
            L E  Q  Q  H    E+    +E  +Q L    R+  FL+ E  LR +E +R +     
Sbjct: 1449 LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQ-E 1507

Query: 82   ARAQRCAKAIVRLDEQNRVDLAQIHWQRAE--LASLYHG---REDGVRAQLLEMEARAAQ 136
             R+Q   +  +  ++Q      Q  + + E  L     G   R+D  R    E + R  +
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567

Query: 137  MAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQ 196
              QQ+   +  +  +LE+  ++R  E+E   M  E        +++  +++   +R+ R+
Sbjct: 1568 EEQQLSRQERDRKFRLEE-QKVRRQEQERKFMEDEQQLRRQEGQQQLRQER---DRKFRE 1623

Query: 197  RVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLH 256
              Q L  R E++  R      +    +  +LR++      R Q L H R +   + EQL 
Sbjct: 1624 DEQLLQEREEQQLHRQ--ERDRKFLEEEPQLRRQ-----EREQQLRHDRDRKFREEEQLL 1676

Query: 257  REHED 261
            +E E+
Sbjct: 1677 QEGEE 1681



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 55/245 (22%), Positives = 104/245 (42%), Gaps = 20/245 (8%)

Query: 32  QYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAI 91
           Q L+ E  L  EQ +  E+ + +   +    +R   RL+ E       +  R +   +  
Sbjct: 530 QRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR 589

Query: 92  VRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVLQ 151
           ++ +++ R++      QR +   +    ++  R Q L+ E    +  QQ+ + +  +  +
Sbjct: 590 LKREQEERLE------QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR 643

Query: 152 LEQLARIRALERE-LLHMRVEHTQLLHRVKRRFLEDKAAFE------REARQRVQSLARR 204
            +QL R +   RE  L    E  +L  R+KR   E++   E       +AR+R++S   +
Sbjct: 644 QQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703

Query: 205 ----AEREA-VRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREH 259
                E EA  R    +++  K +  R RQE     RR +     + Q  E+  +  +E 
Sbjct: 704 WQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE--SELQWQEEERAHRQQQEE 761

Query: 260 EDTRD 264
           E  RD
Sbjct: 762 EQRRD 766



 Score = 37.4 bits (85), Expect = 0.027
 Identities = 56/232 (24%), Positives = 88/232 (37%), Gaps = 14/232 (6%)

Query: 29   ERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCA 88
            ERAQ LQ E   L E  +    S +Q   +      E  R R  + LYA        R  
Sbjct: 844  ERAQQLQEEEDGLQEDQER-RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE 902

Query: 89   KAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYK 148
            + +++ +E+      +   +R E    Y   E   + +   +     +  +Q +E Q  K
Sbjct: 903  QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK 962

Query: 149  VLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQRVQSLARRAERE 208
              +L+Q       E +LL    E        +RR   +K   E E  Q+ +    R ERE
Sbjct: 963  DKKLQQK------EEQLLGEEPEK-------RRRQEREKKYREEEELQQEEEQLLREERE 1009

Query: 209  AVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREHE 260
              R      Q  K D  +  +E LL   R +     R +   + E+L +E E
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEE 1061



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 56/252 (22%), Positives = 98/252 (38%), Gaps = 46/252 (18%)

Query: 35   QREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVRL 94
            Q+E  LL E+     E   +  RE  + + E L+  EE  L       R Q   +   + 
Sbjct: 968  QKEEQLLGEE----PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023

Query: 95   DEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQ 154
            DE  + +   +             RE+  + +L E E R  +  +++Q+ +   + +  +
Sbjct: 1024 DELQQEEEQLL-------------REEREKRRLQERE-RQYREEEELQQEEEQLLGEERE 1069

Query: 155  LARIRALERELL---HMRVEHTQLLHRV---KRRFLEDKAAFEREARQRVQSLARRAERE 208
              R + LER+      ++ E  QLL      +RR   ++   E E  Q+ +    R ERE
Sbjct: 1070 TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE 1129

Query: 209  AVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQ------REQLHREHEDT 262
                             R RQEL    R  + +     QLL +      R++L R++ + 
Sbjct: 1130 K----------------RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173

Query: 263  RDLARVHGWLRR 274
             +L +    L R
Sbjct: 1174 EELQQEEEQLLR 1185


>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
          Length = 495

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 54/254 (21%), Positives = 104/254 (40%), Gaps = 25/254 (9%)

Query: 30  RAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAK 89
           +AQY       L EQ    +E+ +Q+L+E   +D    ++ EE++L       +     +
Sbjct: 184 KAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRR 243

Query: 90  AIVRLDEQ-------NRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQ 142
            I    ++        R ++ + + +  E A++   RE+   A++ E E +  Q+   + 
Sbjct: 244 YIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALT 303

Query: 143 ELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDK--------------- 187
           +     + Q E L ++R    +     +  ++L    +++  + K               
Sbjct: 304 QKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKEL 363

Query: 188 ---AAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHT 244
              AA E E   R   LA+ AE + +  + A  Q +K    R   E L+  RR Q L   
Sbjct: 364 VLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADK 423

Query: 245 RRQLLEQREQLHRE 258
           +R+L E + Q  R+
Sbjct: 424 QRELEEWQLQQRRQ 437


>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
          Length = 1476

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 80/327 (24%), Positives = 129/327 (39%), Gaps = 41/327 (12%)

Query: 128 LEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFL--- 184
           L++    AQ+ +  QEL+    L L+  A ++ LE E+  +R E   L  + KR  L   
Sbjct: 258 LQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYRE 317

Query: 185 EDKAAFEREAR-QRVQSLARRAEREAVRALVAH----------TQAIKADNGRLRQELLL 233
           E +A  ER  R  R+Q   RR  RE ++A  A+          +  ++A    L ++L  
Sbjct: 318 EAEALRERAGRLPRLQEELRRC-RERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEA 376

Query: 234 LLRRTQLLHHTRRQLLEQREQLHREHEDTRDLARVHGWLRRGPGGPPLWERPAFSQPTSR 293
              R   LH T+R+ L  R +L   H +   L      L        L  + +   P   
Sbjct: 377 ARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGS 436

Query: 294 PGSLAAPISPSRAASQTPSVVPSRAAPRASSVVPSREASRVPSLVLSSMDSR-VPSLATS 352
           PG   AP+              + AAP     V   EA R+ +L   + + R +  +   
Sbjct: 437 PGE--APL--------------AGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQG 480

Query: 353 KVGSRMPSLTASRAGSRALSLVQSLEGSGISSGSSPRVSSQDTLRSTKSGPKLLSGLSRD 412
           + G + P L A R     L +++    + ++   SP+   Q   ++   GP+ L     D
Sbjct: 481 QPGGQHPLLEAPRE-DPVLPVLEEAPQTPVAFDHSPQGLVQ---KARDGGPQAL-----D 531

Query: 413 RDPALLPPQSEDSVNAEAAAEASPGRA 439
             P  L    E S     A ++ P  A
Sbjct: 532 LAPPALDSVLEASAECPQAPDSDPQEA 558



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 64/246 (26%), Positives = 111/246 (45%), Gaps = 19/246 (7%)

Query: 19   AAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENR-LYA 77
            AA  +++    + Q L R+H  L++     E  ++ +L  +  L      L   +R L  
Sbjct: 1059 AARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQG 1118

Query: 78   SYVSARAQRC---AKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARA 134
             +   +AQR    A+ +  L E+ R+ +   H QR     L   + +  RAQ+L      
Sbjct: 1119 RHEQLQAQRASVEAQEVALLAERERL-MQDGHRQRGLEEELRRLQSEHDRAQML-----L 1172

Query: 135  AQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAFEREA 194
            A+++++  ELQ  +     +LAR+  LER  L M+   +Q L    ++   D +A     
Sbjct: 1173 AELSRERGELQGERGELRGRLARLE-LERAQLEMQ---SQQLRESNQQL--DLSACRLTT 1226

Query: 195  RQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQ 254
            +  + +  R A+ E  R L+A  QA+  +N   R+ L   L     LH  +R+ L+Q   
Sbjct: 1227 QCELLTQLRSAQEEENRQLLAEVQALSREN---RELLERSLESRDHLHREQREYLDQLNA 1283

Query: 255  LHREHE 260
            L RE +
Sbjct: 1284 LRREKQ 1289



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 49/185 (26%), Positives = 85/185 (45%), Gaps = 17/185 (9%)

Query: 24   EQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSAR 83
            EQ  ++RA    +E ALL+E+     E + Q       L+ E  RL+ E+   A  + A 
Sbjct: 1121 EQLQAQRASVEAQEVALLAER-----ERLMQDGHRQRGLEEELRRLQSEHDR-AQMLLAE 1174

Query: 84   AQRCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQE 143
              R    +     + R  LA++  +RA+L      +   +R    +++  A ++  Q + 
Sbjct: 1175 LSRERGELQGERGELRGRLARLELERAQLEM----QSQQLRESNQQLDLSACRLTTQCEL 1230

Query: 144  LQPYKVLQLEQ----LARIRALERE---LLHMRVEHTQLLHRVKRRFLEDKAAFEREARQ 196
            L   +  Q E+    LA ++AL RE   LL   +E    LHR +R +L+   A  RE ++
Sbjct: 1231 LTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQK 1290

Query: 197  RVQSL 201
             V+ +
Sbjct: 1291 LVEKI 1295



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 65/262 (24%), Positives = 108/262 (41%), Gaps = 29/262 (11%)

Query: 19   AAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYAS 78
            AAAG E     R Q+ +RE + L  Q +  EE +  +  E      EA R R E     +
Sbjct: 819  AAAGRE-----RRQW-EREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQA 872

Query: 79   YVSARAQRCAKAIVRLDEQNRVDLAQIHWQRAELA---SLYHGREDGVRAQL-LEMEARA 134
             +     R  +   RL+   R +L Q   +R E        H R  G+  +L  E++A A
Sbjct: 873  ELEKAVVRGKELGARLEHLQR-ELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAA 931

Query: 135  AQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLE--------- 185
                + + EL+   +   E+L ++R     L   +    QL+     R +E         
Sbjct: 932  TSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLV 991

Query: 186  -DKAAFEREARQ---RVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRTQLL 241
             +KAA + + +    ++ SL  RA+      L+  +Q  +  + RL+ E  +L  + Q L
Sbjct: 992  AEKAALQGQLQHLEGQLGSLQGRAQE-----LLLQSQRAQEHSSRLQAEKSVLEIQGQEL 1046

Query: 242  HHTRRQLLEQREQLHREHEDTR 263
            H     L E+     +  E+TR
Sbjct: 1047 HRKLEVLEEEVRAARQSQEETR 1068



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 69/284 (24%), Positives = 112/284 (39%), Gaps = 59/284 (20%)

Query: 19   AAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYAS 78
            A A  +  L E  +   +E    S++ +   E++    RE    +RE  RLR        
Sbjct: 785  AQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLR-------- 836

Query: 79   YVSARAQRCAKAIVRLDEQNRVDLAQIHWQRAELASL--------YHGREDGVRAQLLEM 130
               A+++   + +  L+ + R  L +   +R E  +L          G+E G R + L+ 
Sbjct: 837  ---AQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQR 893

Query: 131  EARAAQMAQQ----VQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLE- 185
            E   A + +Q     +E Q  +   LEQ      LE EL        + L  +K R L+ 
Sbjct: 894  ELEQAALERQEFLREKESQHQRYQGLEQ-----RLEAELQAAATSKEEALMELKTRALQL 948

Query: 186  DKAAFEREARQRVQSLARRAEREAVR---------------------ALVAHTQAIKADN 224
            ++  F+           +RAE + V                      AL    Q ++   
Sbjct: 949  EEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQL 1008

Query: 225  GRLR---QELLLLLRRTQLLHHTRRQ----LLE-QREQLHREHE 260
            G L+   QELLL  +R Q  H +R Q    +LE Q ++LHR+ E
Sbjct: 1009 GSLQGRAQELLLQSQRAQ-EHSSRLQAEKSVLEIQGQELHRKLE 1051



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 43/156 (27%), Positives = 64/156 (41%), Gaps = 22/156 (14%)

Query: 109 RAELASLYHGRE---DGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALEREL 165
           R E+A L    E   D + AQ  ++EA+  + A+  +EL   +  + E         RE 
Sbjct: 731 REEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEA-------HREA 783

Query: 166 LHMRVEHTQLLHRVKRRFLE-DKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADN 224
                E  +L   V+    E + A+ EREA     + A R  R+  R           + 
Sbjct: 784 EAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWER-----------EG 832

Query: 225 GRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREHE 260
            RLR +      R Q+L    RQ LE+ E+  RE E
Sbjct: 833 SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKE 868



 Score = 33.5 bits (75), Expect = 0.39
 Identities = 75/299 (25%), Positives = 114/299 (38%), Gaps = 57/299 (19%)

Query: 18   AAAAGAEQPLSE-RAQYLQREHALLS----------------EQLDTCEESVDQVLRENA 60
            AAA   E+ L E + + LQ E  L                  + ++T    + +V R NA
Sbjct: 929  AAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNA 988

Query: 61   FLDREALRLREENRLYASYVSARAQRCAKAIVRLDEQNRVDLAQIHWQR--AELASL-YH 117
             L  E   L+ + +     + +   R  + +++         AQ H  R  AE + L   
Sbjct: 989  MLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQR------AQEHSSRLQAEKSVLEIQ 1042

Query: 118  GREDGVRAQLLEMEARAAQMAQQ---------------VQELQPYKVLQLEQL------- 155
            G+E   + ++LE E RAA+ +Q+               + +LQ  +  +LE L       
Sbjct: 1043 GQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDL 1102

Query: 156  -ARIRALERELLHMRVEHTQL-LHRVKRRFLEDKAAFEREARQRVQSLARRAEREAVRAL 213
             A +RALE     ++  H QL   R      E     ERE   +     R  E E  R  
Sbjct: 1103 KANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQ 1162

Query: 214  VAHTQA------IKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREHEDTRDLA 266
              H +A      +  + G L+ E   L  R   L   R QL  Q +QL RE     DL+
Sbjct: 1163 SEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQL-RESNQQLDLS 1220


>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
           sapiens]
          Length = 693

 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 65/263 (24%), Positives = 107/263 (40%), Gaps = 26/263 (9%)

Query: 10  SAGSQPGGAAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDR--EAL 67
           S   Q    +++  E  L  R Q   +E ALL+  +    ES+ QV  E     +  +  
Sbjct: 180 STQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGE 239

Query: 68  RLREENRLYASYVSARAQRCAKA--IVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRA 125
           R R + R++   V AR  +  K   I R+ E  R  L+++  Q AE  SL       V  
Sbjct: 240 RARWQERMWKMSVEARTLKEEKKRDIHRIQELER-SLSELKNQMAEPPSLAPPAVTSVVE 298

Query: 126 QLL--------EMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLH 177
           QL         E+E    ++  QV+  Q   +L  EQ  R++  E  L     +      
Sbjct: 299 QLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQ------ 352

Query: 178 RVKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRR 237
               R  E +   E+  R R Q    + + E +R      Q ++    RLR+E   L ++
Sbjct: 353 ----RVREQERLCEQNERLREQQKTLQEQGERLR---KQEQRLRKQEERLRKEEERLQKQ 405

Query: 238 TQLLHHTRRQLLEQREQLHREHE 260
            + L     +L ++ E+L ++ E
Sbjct: 406 EKRLWDQEERLWKKEERLQKQEE 428


>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
           isoform 1 [Homo sapiens]
          Length = 693

 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 65/263 (24%), Positives = 107/263 (40%), Gaps = 26/263 (9%)

Query: 10  SAGSQPGGAAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDR--EAL 67
           S   Q    +++  E  L  R Q   +E ALL+  +    ES+ QV  E     +  +  
Sbjct: 180 STQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGE 239

Query: 68  RLREENRLYASYVSARAQRCAKA--IVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRA 125
           R R + R++   V AR  +  K   I R+ E  R  L+++  Q AE  SL       V  
Sbjct: 240 RARWQERMWKMSVEARTLKEEKKRDIHRIQELER-SLSELKNQMAEPPSLAPPAVTSVVE 298

Query: 126 QLL--------EMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLH 177
           QL         E+E    ++  QV+  Q   +L  EQ  R++  E  L     +      
Sbjct: 299 QLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQ------ 352

Query: 178 RVKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRR 237
               R  E +   E+  R R Q    + + E +R      Q ++    RLR+E   L ++
Sbjct: 353 ----RVREQERLCEQNERLREQQKTLQEQGERLR---KQEQRLRKQEERLRKEEERLQKQ 405

Query: 238 TQLLHHTRRQLLEQREQLHREHE 260
            + L     +L ++ E+L ++ E
Sbjct: 406 EKRLWDQEERLWKKEERLQKQEE 428


>gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo
           sapiens]
          Length = 693

 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 65/263 (24%), Positives = 108/263 (41%), Gaps = 26/263 (9%)

Query: 10  SAGSQPGGAAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDR--EAL 67
           S   Q    +++  E  L  R Q   +E ALL+  +    ES+ QV  E     +  +  
Sbjct: 180 STQQQEEDRSSSCREAVLHRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGE 239

Query: 68  RLREENRLYASYVSARAQRCAKA--IVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRA 125
           R R + R++   V AR  +  K   I R+ E  R  L+++  Q A+  SL       V  
Sbjct: 240 RARWQERMWKMSVEARTLKEEKKRDIHRIQELER-SLSELKNQMAKPPSLAPPAVTSVVE 298

Query: 126 QLL--------EMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLH 177
           QL         E+E    ++  QV+  Q   +L  EQ  R++  E  L    V+      
Sbjct: 299 QLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEVQ------ 352

Query: 178 RVKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRR 237
               R  E +   E+  R R Q    + + E +R      Q ++    RLR+E   L ++
Sbjct: 353 ----RVREQERLCEQNERLREQQKTLQEQGERLR---KQEQRLRKQEERLRKEEERLQKQ 405

Query: 238 TQLLHHTRRQLLEQREQLHREHE 260
            + L     +L ++ E+L ++ E
Sbjct: 406 EKRLWDQEERLWKKEERLQKQEE 428


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 68/286 (23%), Positives = 111/286 (38%), Gaps = 45/286 (15%)

Query: 23   AEQPLSERAQYLQ---REHALLSEQLDTCEESVDQVLRENAFLDREALRLR---EENRLY 76
            AEQ  + RAQ  Q   R+      +++  ++  +Q LR+ A +++E   LR   EE    
Sbjct: 2142 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2201

Query: 77   ASYVSARAQRC---AKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLL----- 128
             + +    QR    A    R   Q   +L  +  Q  EL+ L    E   RA +L     
Sbjct: 2202 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2261

Query: 129  -------------EMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQL 175
                         ++   AA+++   QE    + L  E LA+ RAL  ++L  +++  Q 
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2321

Query: 176  LHRVK-----------------RRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQ 218
              R+K                 RR  EDK    ++  +  Q   R  E E  R L    +
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2381

Query: 219  AIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREHEDTRD 264
            A +    R+ +      R  +     R+Q  E  E+LHR    T++
Sbjct: 2382 AERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 60/259 (23%), Positives = 109/259 (42%), Gaps = 24/259 (9%)

Query: 19   AAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYAS 78
            A A AE+   E  Q +Q       E++   EE+     ++   +  E  +LR+ +     
Sbjct: 1382 AKAQAEREAKELQQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434

Query: 79   YVSARAQRCAKAIVRLDEQNRVDLAQIH-------WQRAELASLYHGREDGVRAQLLEME 131
              + +A+   ++ +R++E+ RV   Q+            EL +L   R +   AQ  + +
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1493

Query: 132  ARAAQMAQQVQ-ELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAF 190
              A ++ +QVQ E Q  +  ++E  +R++A E E    +    Q L  ++ +  E     
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRALQALEELRLQAEE----A 1548

Query: 191  EREARQRVQSLARRAE---REAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQ 247
            ER  RQ     AR+ +     A R+  A  Q+ +A       +L   L+   +     R+
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608

Query: 248  LLEQREQLHREHEDTRDLA 266
              E+R Q   E E  R+ A
Sbjct: 1609 EAERRAQQQAEAERAREEA 1627



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 66/271 (24%), Positives = 119/271 (43%), Gaps = 46/271 (16%)

Query: 29   ERAQYLQREHALLSEQLD--------TCEESVDQVLRENAFLDREALRLREENRLYASYV 80
            E+A+ LQ +   +++QL         T E    + L  +A  +R  LR+ E +R  A   
Sbjct: 2341 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-A 2399

Query: 81   SARAQRCAKAIVRLDEQ-NRVDLA-----------QIHWQRAE---------LASLYHGR 119
               AQR  K    + E+ +R +LA           +I  Q+++         +A L   +
Sbjct: 2400 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459

Query: 120  ED-GVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR 178
            E     A+LL++++   Q  QQ Q LQ  + LQ   L+     E++ L  R    +    
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS-----EKDSLLQRERFIEQEKA 2514

Query: 179  VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIK----ADNG-RLRQELLL 233
               +  +D+ A  ++ R+  Q   ++ E+E  R + +  +A +    A+ G R +QE L 
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574

Query: 234  LL-----RRTQLLHHTRRQLLEQREQLHREH 259
             L     ++ +LL    ++L EQ + L  +H
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 59/250 (23%), Positives = 95/250 (38%), Gaps = 37/250 (14%)

Query: 34   LQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVR 93
            LQ EH  +++  +  E    Q          EA R REE          +A    +  ++
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELERWQLKANEALRLRLQ 1647

Query: 94   LDE---QNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVL 150
             +E   Q  +  A+   Q+ E       RE   R +  E   R  ++A+Q  EL+  + L
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQ--ELEKQRQL 1700

Query: 151  QLEQLARIRALERELLHMRVE------HTQLLHRVKRRFLEDKAAFEREARQRVQSLAR- 203
                  +  A E+EL+ +R E        QLL     R   + AA  ++ ++    LA+ 
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760

Query: 204  RAEREAVRALVAHT------------QAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQ 251
            RAE E + A  A              Q ++A+ GR R+      R   L    +RQ    
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820

Query: 252  REQLHREHED 261
             E   R+  +
Sbjct: 1821 EEDAARQRAE 1830



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 65/264 (24%), Positives = 105/264 (39%), Gaps = 36/264 (13%)

Query: 18   AAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYA 77
            AAA  AE  L      L R  +   + L + E++  +  R+      E  R RE      
Sbjct: 1937 AAAGKAELELE-----LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991

Query: 78   SYVSARAQRCAKAIVRLDEQNR----VDLAQIHWQRAELAS---LYHGREDGVRAQLLEM 130
              ++A  +   +    L+E  R    V+ A+   +RAE  S   L   +E   +    E 
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051

Query: 131  EARAAQMAQQVQELQPYKVLQLEQ-----------LARIRALERELLHMRVEHTQLLHR- 178
            +A A  + Q+ QELQ  + LQ EQ            AR  A E E   ++ E      R 
Sbjct: 2052 KAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109

Query: 179  --VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLR 236
               +   L+  A  + +AR + Q+ A +  +EA +      Q   A+   LRQ+      
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQK---QAA 2163

Query: 237  RTQLLHHTR--RQLLEQREQLHRE 258
              ++  H +   Q L Q+ Q+ +E
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQE 2187



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 35/141 (24%), Positives = 59/141 (41%), Gaps = 6/141 (4%)

Query: 28   SERAQYLQREHALLSEQL--DTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQ 85
            SE  Q +Q+E  L   Q    +     D +L+   F+++E  +L +   L+   V A+AQ
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ---LFQDEV-AKAQ 2528

Query: 86   RCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQ 145
            +  +   R  +Q   +  ++     E     H  E+GVR +  E++    Q  QQ + L 
Sbjct: 2529 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2588

Query: 146  PYKVLQLEQLARIRALERELL 166
                   EQL  +    R  L
Sbjct: 2589 EENQRLREQLQLLEEQHRAAL 2609



 Score = 33.5 bits (75), Expect = 0.39
 Identities = 61/261 (23%), Positives = 99/261 (37%), Gaps = 26/261 (9%)

Query: 25   QPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARA 84
            Q L E    LQRE A  +++    E  + +V  E   L     R  EE+R  +     R 
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789

Query: 85   QRCAKAIVRLDEQN---RVDLAQIHWQR---AELASLYHGREDGVRAQLLEMEARAAQMA 138
            +  A     L E+    R    +   QR    E A+      + V A+ L     A ++ 
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849

Query: 139  QQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR--VKRRFLEDKAAFEREARQ 196
             + +     K  + E+L R+ A +      R+E     H+  ++ R  + + A + E  +
Sbjct: 1850 TEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL-E 1907

Query: 197  RVQSLA------RRAEREAVRALVAHTQAIKADNGRLRQEL----------LLLLRRTQL 240
            R + L       RR   E + AL A  +   A    L  EL          L    + +L
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967

Query: 241  LHHTRRQLLEQREQLHREHED 261
                +RQL  + E+  RE E+
Sbjct: 1968 EAARQRQLAAEEERRRREAEE 1988


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 68/286 (23%), Positives = 111/286 (38%), Gaps = 45/286 (15%)

Query: 23   AEQPLSERAQYLQ---REHALLSEQLDTCEESVDQVLRENAFLDREALRLR---EENRLY 76
            AEQ  + RAQ  Q   R+      +++  ++  +Q LR+ A +++E   LR   EE    
Sbjct: 2146 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2205

Query: 77   ASYVSARAQRC---AKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLL----- 128
             + +    QR    A    R   Q   +L  +  Q  EL+ L    E   RA +L     
Sbjct: 2206 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2265

Query: 129  -------------EMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQL 175
                         ++   AA+++   QE    + L  E LA+ RAL  ++L  +++  Q 
Sbjct: 2266 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2325

Query: 176  LHRVK-----------------RRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQ 218
              R+K                 RR  EDK    ++  +  Q   R  E E  R L    +
Sbjct: 2326 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2385

Query: 219  AIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREHEDTRD 264
            A +    R+ +      R  +     R+Q  E  E+LHR    T++
Sbjct: 2386 AERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2430



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 60/259 (23%), Positives = 109/259 (42%), Gaps = 24/259 (9%)

Query: 19   AAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYAS 78
            A A AE+   E  Q +Q       E++   EE+     ++   +  E  +LR+ +     
Sbjct: 1386 AKAQAEREAKELQQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1438

Query: 79   YVSARAQRCAKAIVRLDEQNRVDLAQIH-------WQRAELASLYHGREDGVRAQLLEME 131
              + +A+   ++ +R++E+ RV   Q+            EL +L   R +   AQ  + +
Sbjct: 1439 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1497

Query: 132  ARAAQMAQQVQ-ELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAF 190
              A ++ +QVQ E Q  +  ++E  +R++A E E    +    Q L  ++ +  E     
Sbjct: 1498 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRALQALEELRLQAEE----A 1552

Query: 191  EREARQRVQSLARRAE---REAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQ 247
            ER  RQ     AR+ +     A R+  A  Q+ +A       +L   L+   +     R+
Sbjct: 1553 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1612

Query: 248  LLEQREQLHREHEDTRDLA 266
              E+R Q   E E  R+ A
Sbjct: 1613 EAERRAQQQAEAERAREEA 1631



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 66/271 (24%), Positives = 119/271 (43%), Gaps = 46/271 (16%)

Query: 29   ERAQYLQREHALLSEQLD--------TCEESVDQVLRENAFLDREALRLREENRLYASYV 80
            E+A+ LQ +   +++QL         T E    + L  +A  +R  LR+ E +R  A   
Sbjct: 2345 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-A 2403

Query: 81   SARAQRCAKAIVRLDEQ-NRVDLA-----------QIHWQRAE---------LASLYHGR 119
               AQR  K    + E+ +R +LA           +I  Q+++         +A L   +
Sbjct: 2404 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2463

Query: 120  ED-GVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR 178
            E     A+LL++++   Q  QQ Q LQ  + LQ   L+     E++ L  R    +    
Sbjct: 2464 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS-----EKDSLLQRERFIEQEKA 2518

Query: 179  VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIK----ADNG-RLRQELLL 233
               +  +D+ A  ++ R+  Q   ++ E+E  R + +  +A +    A+ G R +QE L 
Sbjct: 2519 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2578

Query: 234  LL-----RRTQLLHHTRRQLLEQREQLHREH 259
             L     ++ +LL    ++L EQ + L  +H
Sbjct: 2579 QLEQQRRQQEELLAEENQRLREQLQLLEEQH 2609



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 59/250 (23%), Positives = 95/250 (38%), Gaps = 37/250 (14%)

Query: 34   LQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVR 93
            LQ EH  +++  +  E    Q          EA R REE          +A    +  ++
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELERWQLKANEALRLRLQ 1651

Query: 94   LDE---QNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVL 150
             +E   Q  +  A+   Q+ E       RE   R +  E   R  ++A+Q  EL+  + L
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQ--ELEKQRQL 1704

Query: 151  QLEQLARIRALERELLHMRVE------HTQLLHRVKRRFLEDKAAFEREARQRVQSLAR- 203
                  +  A E+EL+ +R E        QLL     R   + AA  ++ ++    LA+ 
Sbjct: 1705 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1764

Query: 204  RAEREAVRALVAHT------------QAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQ 251
            RAE E + A  A              Q ++A+ GR R+      R   L    +RQ    
Sbjct: 1765 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1824

Query: 252  REQLHREHED 261
             E   R+  +
Sbjct: 1825 EEDAARQRAE 1834



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 65/264 (24%), Positives = 105/264 (39%), Gaps = 36/264 (13%)

Query: 18   AAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYA 77
            AAA  AE  L      L R  +   + L + E++  +  R+      E  R RE      
Sbjct: 1941 AAAGKAELELE-----LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1995

Query: 78   SYVSARAQRCAKAIVRLDEQNR----VDLAQIHWQRAELAS---LYHGREDGVRAQLLEM 130
              ++A  +   +    L+E  R    V+ A+   +RAE  S   L   +E   +    E 
Sbjct: 1996 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2055

Query: 131  EARAAQMAQQVQELQPYKVLQLEQ-----------LARIRALERELLHMRVEHTQLLHR- 178
            +A A  + Q+ QELQ  + LQ EQ            AR  A E E   ++ E      R 
Sbjct: 2056 KAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2113

Query: 179  --VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLR 236
               +   L+  A  + +AR + Q+ A +  +EA +      Q   A+   LRQ+      
Sbjct: 2114 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQK---QAA 2167

Query: 237  RTQLLHHTR--RQLLEQREQLHRE 258
              ++  H +   Q L Q+ Q+ +E
Sbjct: 2168 DAEMEKHKKFAEQTLRQKAQVEQE 2191



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 35/141 (24%), Positives = 59/141 (41%), Gaps = 6/141 (4%)

Query: 28   SERAQYLQREHALLSEQL--DTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQ 85
            SE  Q +Q+E  L   Q    +     D +L+   F+++E  +L +   L+   V A+AQ
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ---LFQDEV-AKAQ 2532

Query: 86   RCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQ 145
            +  +   R  +Q   +  ++     E     H  E+GVR +  E++    Q  QQ + L 
Sbjct: 2533 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2592

Query: 146  PYKVLQLEQLARIRALERELL 166
                   EQL  +    R  L
Sbjct: 2593 EENQRLREQLQLLEEQHRAAL 2613



 Score = 33.5 bits (75), Expect = 0.39
 Identities = 61/261 (23%), Positives = 99/261 (37%), Gaps = 26/261 (9%)

Query: 25   QPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARA 84
            Q L E    LQRE A  +++    E  + +V  E   L     R  EE+R  +     R 
Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1793

Query: 85   QRCAKAIVRLDEQN---RVDLAQIHWQR---AELASLYHGREDGVRAQLLEMEARAAQMA 138
            +  A     L E+    R    +   QR    E A+      + V A+ L     A ++ 
Sbjct: 1794 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1853

Query: 139  QQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR--VKRRFLEDKAAFEREARQ 196
             + +     K  + E+L R+ A +      R+E     H+  ++ R  + + A + E  +
Sbjct: 1854 TEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL-E 1911

Query: 197  RVQSLA------RRAEREAVRALVAHTQAIKADNGRLRQEL----------LLLLRRTQL 240
            R + L       RR   E + AL A  +   A    L  EL          L    + +L
Sbjct: 1912 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1971

Query: 241  LHHTRRQLLEQREQLHREHED 261
                +RQL  + E+  RE E+
Sbjct: 1972 EAARQRQLAAEEERRRREAEE 1992


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 68/286 (23%), Positives = 111/286 (38%), Gaps = 45/286 (15%)

Query: 23   AEQPLSERAQYLQ---REHALLSEQLDTCEESVDQVLRENAFLDREALRLR---EENRLY 76
            AEQ  + RAQ  Q   R+      +++  ++  +Q LR+ A +++E   LR   EE    
Sbjct: 2142 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2201

Query: 77   ASYVSARAQRC---AKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLL----- 128
             + +    QR    A    R   Q   +L  +  Q  EL+ L    E   RA +L     
Sbjct: 2202 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2261

Query: 129  -------------EMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQL 175
                         ++   AA+++   QE    + L  E LA+ RAL  ++L  +++  Q 
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2321

Query: 176  LHRVK-----------------RRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQ 218
              R+K                 RR  EDK    ++  +  Q   R  E E  R L    +
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2381

Query: 219  AIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREHEDTRD 264
            A +    R+ +      R  +     R+Q  E  E+LHR    T++
Sbjct: 2382 AERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 60/259 (23%), Positives = 109/259 (42%), Gaps = 24/259 (9%)

Query: 19   AAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYAS 78
            A A AE+   E  Q +Q       E++   EE+     ++   +  E  +LR+ +     
Sbjct: 1382 AKAQAEREAKELQQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434

Query: 79   YVSARAQRCAKAIVRLDEQNRVDLAQIH-------WQRAELASLYHGREDGVRAQLLEME 131
              + +A+   ++ +R++E+ RV   Q+            EL +L   R +   AQ  + +
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1493

Query: 132  ARAAQMAQQVQ-ELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAF 190
              A ++ +QVQ E Q  +  ++E  +R++A E E    +    Q L  ++ +  E     
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRALQALEELRLQAEE----A 1548

Query: 191  EREARQRVQSLARRAE---REAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQ 247
            ER  RQ     AR+ +     A R+  A  Q+ +A       +L   L+   +     R+
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608

Query: 248  LLEQREQLHREHEDTRDLA 266
              E+R Q   E E  R+ A
Sbjct: 1609 EAERRAQQQAEAERAREEA 1627



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 66/271 (24%), Positives = 119/271 (43%), Gaps = 46/271 (16%)

Query: 29   ERAQYLQREHALLSEQLD--------TCEESVDQVLRENAFLDREALRLREENRLYASYV 80
            E+A+ LQ +   +++QL         T E    + L  +A  +R  LR+ E +R  A   
Sbjct: 2341 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-A 2399

Query: 81   SARAQRCAKAIVRLDEQ-NRVDLA-----------QIHWQRAE---------LASLYHGR 119
               AQR  K    + E+ +R +LA           +I  Q+++         +A L   +
Sbjct: 2400 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459

Query: 120  ED-GVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR 178
            E     A+LL++++   Q  QQ Q LQ  + LQ   L+     E++ L  R    +    
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS-----EKDSLLQRERFIEQEKA 2514

Query: 179  VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIK----ADNG-RLRQELLL 233
               +  +D+ A  ++ R+  Q   ++ E+E  R + +  +A +    A+ G R +QE L 
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574

Query: 234  LL-----RRTQLLHHTRRQLLEQREQLHREH 259
             L     ++ +LL    ++L EQ + L  +H
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 59/250 (23%), Positives = 95/250 (38%), Gaps = 37/250 (14%)

Query: 34   LQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVR 93
            LQ EH  +++  +  E    Q          EA R REE          +A    +  ++
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELERWQLKANEALRLRLQ 1647

Query: 94   LDE---QNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVL 150
             +E   Q  +  A+   Q+ E       RE   R +  E   R  ++A+Q  EL+  + L
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQ--ELEKQRQL 1700

Query: 151  QLEQLARIRALERELLHMRVE------HTQLLHRVKRRFLEDKAAFEREARQRVQSLAR- 203
                  +  A E+EL+ +R E        QLL     R   + AA  ++ ++    LA+ 
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760

Query: 204  RAEREAVRALVAHT------------QAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQ 251
            RAE E + A  A              Q ++A+ GR R+      R   L    +RQ    
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820

Query: 252  REQLHREHED 261
             E   R+  +
Sbjct: 1821 EEDAARQRAE 1830



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 65/264 (24%), Positives = 105/264 (39%), Gaps = 36/264 (13%)

Query: 18   AAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYA 77
            AAA  AE  L      L R  +   + L + E++  +  R+      E  R RE      
Sbjct: 1937 AAAGKAELELE-----LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991

Query: 78   SYVSARAQRCAKAIVRLDEQNR----VDLAQIHWQRAELAS---LYHGREDGVRAQLLEM 130
              ++A  +   +    L+E  R    V+ A+   +RAE  S   L   +E   +    E 
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051

Query: 131  EARAAQMAQQVQELQPYKVLQLEQ-----------LARIRALERELLHMRVEHTQLLHR- 178
            +A A  + Q+ QELQ  + LQ EQ            AR  A E E   ++ E      R 
Sbjct: 2052 KAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109

Query: 179  --VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLR 236
               +   L+  A  + +AR + Q+ A +  +EA +      Q   A+   LRQ+      
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQK---QAA 2163

Query: 237  RTQLLHHTR--RQLLEQREQLHRE 258
              ++  H +   Q L Q+ Q+ +E
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQE 2187



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 35/141 (24%), Positives = 59/141 (41%), Gaps = 6/141 (4%)

Query: 28   SERAQYLQREHALLSEQL--DTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQ 85
            SE  Q +Q+E  L   Q    +     D +L+   F+++E  +L +   L+   V A+AQ
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ---LFQDEV-AKAQ 2528

Query: 86   RCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQ 145
            +  +   R  +Q   +  ++     E     H  E+GVR +  E++    Q  QQ + L 
Sbjct: 2529 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2588

Query: 146  PYKVLQLEQLARIRALERELL 166
                   EQL  +    R  L
Sbjct: 2589 EENQRLREQLQLLEEQHRAAL 2609



 Score = 33.5 bits (75), Expect = 0.39
 Identities = 61/261 (23%), Positives = 99/261 (37%), Gaps = 26/261 (9%)

Query: 25   QPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARA 84
            Q L E    LQRE A  +++    E  + +V  E   L     R  EE+R  +     R 
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789

Query: 85   QRCAKAIVRLDEQN---RVDLAQIHWQR---AELASLYHGREDGVRAQLLEMEARAAQMA 138
            +  A     L E+    R    +   QR    E A+      + V A+ L     A ++ 
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849

Query: 139  QQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR--VKRRFLEDKAAFEREARQ 196
             + +     K  + E+L R+ A +      R+E     H+  ++ R  + + A + E  +
Sbjct: 1850 TEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL-E 1907

Query: 197  RVQSLA------RRAEREAVRALVAHTQAIKADNGRLRQEL----------LLLLRRTQL 240
            R + L       RR   E + AL A  +   A    L  EL          L    + +L
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967

Query: 241  LHHTRRQLLEQREQLHREHED 261
                +RQL  + E+  RE E+
Sbjct: 1968 EAARQRQLAAEEERRRREAEE 1988


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 68/286 (23%), Positives = 111/286 (38%), Gaps = 45/286 (15%)

Query: 23   AEQPLSERAQYLQ---REHALLSEQLDTCEESVDQVLRENAFLDREALRLR---EENRLY 76
            AEQ  + RAQ  Q   R+      +++  ++  +Q LR+ A +++E   LR   EE    
Sbjct: 2110 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2169

Query: 77   ASYVSARAQRC---AKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLL----- 128
             + +    QR    A    R   Q   +L  +  Q  EL+ L    E   RA +L     
Sbjct: 2170 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2229

Query: 129  -------------EMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQL 175
                         ++   AA+++   QE    + L  E LA+ RAL  ++L  +++  Q 
Sbjct: 2230 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2289

Query: 176  LHRVK-----------------RRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQ 218
              R+K                 RR  EDK    ++  +  Q   R  E E  R L    +
Sbjct: 2290 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2349

Query: 219  AIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREHEDTRD 264
            A +    R+ +      R  +     R+Q  E  E+LHR    T++
Sbjct: 2350 AERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2394



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 60/259 (23%), Positives = 109/259 (42%), Gaps = 24/259 (9%)

Query: 19   AAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYAS 78
            A A AE+   E  Q +Q       E++   EE+     ++   +  E  +LR+ +     
Sbjct: 1350 AKAQAEREAKELQQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1402

Query: 79   YVSARAQRCAKAIVRLDEQNRVDLAQIH-------WQRAELASLYHGREDGVRAQLLEME 131
              + +A+   ++ +R++E+ RV   Q+            EL +L   R +   AQ  + +
Sbjct: 1403 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1461

Query: 132  ARAAQMAQQVQ-ELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAF 190
              A ++ +QVQ E Q  +  ++E  +R++A E E    +    Q L  ++ +  E     
Sbjct: 1462 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRALQALEELRLQAEE----A 1516

Query: 191  EREARQRVQSLARRAE---REAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQ 247
            ER  RQ     AR+ +     A R+  A  Q+ +A       +L   L+   +     R+
Sbjct: 1517 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1576

Query: 248  LLEQREQLHREHEDTRDLA 266
              E+R Q   E E  R+ A
Sbjct: 1577 EAERRAQQQAEAERAREEA 1595



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 66/271 (24%), Positives = 119/271 (43%), Gaps = 46/271 (16%)

Query: 29   ERAQYLQREHALLSEQLD--------TCEESVDQVLRENAFLDREALRLREENRLYASYV 80
            E+A+ LQ +   +++QL         T E    + L  +A  +R  LR+ E +R  A   
Sbjct: 2309 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-A 2367

Query: 81   SARAQRCAKAIVRLDEQ-NRVDLA-----------QIHWQRAE---------LASLYHGR 119
               AQR  K    + E+ +R +LA           +I  Q+++         +A L   +
Sbjct: 2368 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2427

Query: 120  ED-GVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR 178
            E     A+LL++++   Q  QQ Q LQ  + LQ   L+     E++ L  R    +    
Sbjct: 2428 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS-----EKDSLLQRERFIEQEKA 2482

Query: 179  VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIK----ADNG-RLRQELLL 233
               +  +D+ A  ++ R+  Q   ++ E+E  R + +  +A +    A+ G R +QE L 
Sbjct: 2483 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2542

Query: 234  LL-----RRTQLLHHTRRQLLEQREQLHREH 259
             L     ++ +LL    ++L EQ + L  +H
Sbjct: 2543 QLEQQRRQQEELLAEENQRLREQLQLLEEQH 2573



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 59/250 (23%), Positives = 95/250 (38%), Gaps = 37/250 (14%)

Query: 34   LQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVR 93
            LQ EH  +++  +  E    Q          EA R REE          +A    +  ++
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELERWQLKANEALRLRLQ 1615

Query: 94   LDE---QNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVL 150
             +E   Q  +  A+   Q+ E       RE   R +  E   R  ++A+Q  EL+  + L
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQ--ELEKQRQL 1668

Query: 151  QLEQLARIRALERELLHMRVE------HTQLLHRVKRRFLEDKAAFEREARQRVQSLAR- 203
                  +  A E+EL+ +R E        QLL     R   + AA  ++ ++    LA+ 
Sbjct: 1669 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1728

Query: 204  RAEREAVRALVAHT------------QAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQ 251
            RAE E + A  A              Q ++A+ GR R+      R   L    +RQ    
Sbjct: 1729 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1788

Query: 252  REQLHREHED 261
             E   R+  +
Sbjct: 1789 EEDAARQRAE 1798



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 65/264 (24%), Positives = 105/264 (39%), Gaps = 36/264 (13%)

Query: 18   AAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYA 77
            AAA  AE  L      L R  +   + L + E++  +  R+      E  R RE      
Sbjct: 1905 AAAGKAELELE-----LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1959

Query: 78   SYVSARAQRCAKAIVRLDEQNR----VDLAQIHWQRAELAS---LYHGREDGVRAQLLEM 130
              ++A  +   +    L+E  R    V+ A+   +RAE  S   L   +E   +    E 
Sbjct: 1960 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2019

Query: 131  EARAAQMAQQVQELQPYKVLQLEQ-----------LARIRALERELLHMRVEHTQLLHR- 178
            +A A  + Q+ QELQ  + LQ EQ            AR  A E E   ++ E      R 
Sbjct: 2020 KAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2077

Query: 179  --VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLR 236
               +   L+  A  + +AR + Q+ A +  +EA +      Q   A+   LRQ+      
Sbjct: 2078 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQK---QAA 2131

Query: 237  RTQLLHHTR--RQLLEQREQLHRE 258
              ++  H +   Q L Q+ Q+ +E
Sbjct: 2132 DAEMEKHKKFAEQTLRQKAQVEQE 2155



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 35/141 (24%), Positives = 59/141 (41%), Gaps = 6/141 (4%)

Query: 28   SERAQYLQREHALLSEQL--DTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQ 85
            SE  Q +Q+E  L   Q    +     D +L+   F+++E  +L +   L+   V A+AQ
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ---LFQDEV-AKAQ 2496

Query: 86   RCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQ 145
            +  +   R  +Q   +  ++     E     H  E+GVR +  E++    Q  QQ + L 
Sbjct: 2497 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2556

Query: 146  PYKVLQLEQLARIRALERELL 166
                   EQL  +    R  L
Sbjct: 2557 EENQRLREQLQLLEEQHRAAL 2577



 Score = 33.5 bits (75), Expect = 0.39
 Identities = 61/261 (23%), Positives = 99/261 (37%), Gaps = 26/261 (9%)

Query: 25   QPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARA 84
            Q L E    LQRE A  +++    E  + +V  E   L     R  EE+R  +     R 
Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1757

Query: 85   QRCAKAIVRLDEQN---RVDLAQIHWQR---AELASLYHGREDGVRAQLLEMEARAAQMA 138
            +  A     L E+    R    +   QR    E A+      + V A+ L     A ++ 
Sbjct: 1758 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1817

Query: 139  QQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR--VKRRFLEDKAAFEREARQ 196
             + +     K  + E+L R+ A +      R+E     H+  ++ R  + + A + E  +
Sbjct: 1818 TEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL-E 1875

Query: 197  RVQSLA------RRAEREAVRALVAHTQAIKADNGRLRQEL----------LLLLRRTQL 240
            R + L       RR   E + AL A  +   A    L  EL          L    + +L
Sbjct: 1876 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1935

Query: 241  LHHTRRQLLEQREQLHREHED 261
                +RQL  + E+  RE E+
Sbjct: 1936 EAARQRQLAAEEERRRREAEE 1956


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 68/286 (23%), Positives = 111/286 (38%), Gaps = 45/286 (15%)

Query: 23   AEQPLSERAQYLQ---REHALLSEQLDTCEESVDQVLRENAFLDREALRLR---EENRLY 76
            AEQ  + RAQ  Q   R+      +++  ++  +Q LR+ A +++E   LR   EE    
Sbjct: 2279 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2338

Query: 77   ASYVSARAQRC---AKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLL----- 128
             + +    QR    A    R   Q   +L  +  Q  EL+ L    E   RA +L     
Sbjct: 2339 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2398

Query: 129  -------------EMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQL 175
                         ++   AA+++   QE    + L  E LA+ RAL  ++L  +++  Q 
Sbjct: 2399 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2458

Query: 176  LHRVK-----------------RRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQ 218
              R+K                 RR  EDK    ++  +  Q   R  E E  R L    +
Sbjct: 2459 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2518

Query: 219  AIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREHEDTRD 264
            A +    R+ +      R  +     R+Q  E  E+LHR    T++
Sbjct: 2519 AERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2563



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 60/259 (23%), Positives = 109/259 (42%), Gaps = 24/259 (9%)

Query: 19   AAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYAS 78
            A A AE+   E  Q +Q       E++   EE+     ++   +  E  +LR+ +     
Sbjct: 1519 AKAQAEREAKELQQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1571

Query: 79   YVSARAQRCAKAIVRLDEQNRVDLAQIH-------WQRAELASLYHGREDGVRAQLLEME 131
              + +A+   ++ +R++E+ RV   Q+            EL +L   R +   AQ  + +
Sbjct: 1572 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1630

Query: 132  ARAAQMAQQVQ-ELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAF 190
              A ++ +QVQ E Q  +  ++E  +R++A E E    +    Q L  ++ +  E     
Sbjct: 1631 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRALQALEELRLQAEE----A 1685

Query: 191  EREARQRVQSLARRAE---REAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQ 247
            ER  RQ     AR+ +     A R+  A  Q+ +A       +L   L+   +     R+
Sbjct: 1686 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1745

Query: 248  LLEQREQLHREHEDTRDLA 266
              E+R Q   E E  R+ A
Sbjct: 1746 EAERRAQQQAEAERAREEA 1764



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 66/271 (24%), Positives = 119/271 (43%), Gaps = 46/271 (16%)

Query: 29   ERAQYLQREHALLSEQLD--------TCEESVDQVLRENAFLDREALRLREENRLYASYV 80
            E+A+ LQ +   +++QL         T E    + L  +A  +R  LR+ E +R  A   
Sbjct: 2478 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-A 2536

Query: 81   SARAQRCAKAIVRLDEQ-NRVDLA-----------QIHWQRAE---------LASLYHGR 119
               AQR  K    + E+ +R +LA           +I  Q+++         +A L   +
Sbjct: 2537 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2596

Query: 120  ED-GVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR 178
            E     A+LL++++   Q  QQ Q LQ  + LQ   L+     E++ L  R    +    
Sbjct: 2597 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS-----EKDSLLQRERFIEQEKA 2651

Query: 179  VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIK----ADNG-RLRQELLL 233
               +  +D+ A  ++ R+  Q   ++ E+E  R + +  +A +    A+ G R +QE L 
Sbjct: 2652 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711

Query: 234  LL-----RRTQLLHHTRRQLLEQREQLHREH 259
             L     ++ +LL    ++L EQ + L  +H
Sbjct: 2712 QLEQQRRQQEELLAEENQRLREQLQLLEEQH 2742



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 59/250 (23%), Positives = 95/250 (38%), Gaps = 37/250 (14%)

Query: 34   LQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVR 93
            LQ EH  +++  +  E    Q          EA R REE          +A    +  ++
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELERWQLKANEALRLRLQ 1784

Query: 94   LDE---QNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVL 150
             +E   Q  +  A+   Q+ E       RE   R +  E   R  ++A+Q  EL+  + L
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQ--ELEKQRQL 1837

Query: 151  QLEQLARIRALERELLHMRVE------HTQLLHRVKRRFLEDKAAFEREARQRVQSLAR- 203
                  +  A E+EL+ +R E        QLL     R   + AA  ++ ++    LA+ 
Sbjct: 1838 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1897

Query: 204  RAEREAVRALVAHT------------QAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQ 251
            RAE E + A  A              Q ++A+ GR R+      R   L    +RQ    
Sbjct: 1898 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1957

Query: 252  REQLHREHED 261
             E   R+  +
Sbjct: 1958 EEDAARQRAE 1967



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 65/264 (24%), Positives = 105/264 (39%), Gaps = 36/264 (13%)

Query: 18   AAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYA 77
            AAA  AE  L      L R  +   + L + E++  +  R+      E  R RE      
Sbjct: 2074 AAAGKAELELE-----LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2128

Query: 78   SYVSARAQRCAKAIVRLDEQNR----VDLAQIHWQRAELAS---LYHGREDGVRAQLLEM 130
              ++A  +   +    L+E  R    V+ A+   +RAE  S   L   +E   +    E 
Sbjct: 2129 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188

Query: 131  EARAAQMAQQVQELQPYKVLQLEQ-----------LARIRALERELLHMRVEHTQLLHR- 178
            +A A  + Q+ QELQ  + LQ EQ            AR  A E E   ++ E      R 
Sbjct: 2189 KAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2246

Query: 179  --VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLR 236
               +   L+  A  + +AR + Q+ A +  +EA +      Q   A+   LRQ+      
Sbjct: 2247 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQK---QAA 2300

Query: 237  RTQLLHHTR--RQLLEQREQLHRE 258
              ++  H +   Q L Q+ Q+ +E
Sbjct: 2301 DAEMEKHKKFAEQTLRQKAQVEQE 2324



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 35/141 (24%), Positives = 59/141 (41%), Gaps = 6/141 (4%)

Query: 28   SERAQYLQREHALLSEQL--DTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQ 85
            SE  Q +Q+E  L   Q    +     D +L+   F+++E  +L +   L+   V A+AQ
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ---LFQDEV-AKAQ 2665

Query: 86   RCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQ 145
            +  +   R  +Q   +  ++     E     H  E+GVR +  E++    Q  QQ + L 
Sbjct: 2666 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2725

Query: 146  PYKVLQLEQLARIRALERELL 166
                   EQL  +    R  L
Sbjct: 2726 EENQRLREQLQLLEEQHRAAL 2746



 Score = 33.5 bits (75), Expect = 0.39
 Identities = 61/261 (23%), Positives = 99/261 (37%), Gaps = 26/261 (9%)

Query: 25   QPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARA 84
            Q L E    LQRE A  +++    E  + +V  E   L     R  EE+R  +     R 
Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1926

Query: 85   QRCAKAIVRLDEQN---RVDLAQIHWQR---AELASLYHGREDGVRAQLLEMEARAAQMA 138
            +  A     L E+    R    +   QR    E A+      + V A+ L     A ++ 
Sbjct: 1927 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1986

Query: 139  QQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR--VKRRFLEDKAAFEREARQ 196
             + +     K  + E+L R+ A +      R+E     H+  ++ R  + + A + E  +
Sbjct: 1987 TEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL-E 2044

Query: 197  RVQSLA------RRAEREAVRALVAHTQAIKADNGRLRQEL----------LLLLRRTQL 240
            R + L       RR   E + AL A  +   A    L  EL          L    + +L
Sbjct: 2045 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 2104

Query: 241  LHHTRRQLLEQREQLHREHED 261
                +RQL  + E+  RE E+
Sbjct: 2105 EAARQRQLAAEEERRRREAEE 2125


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 68/286 (23%), Positives = 111/286 (38%), Gaps = 45/286 (15%)

Query: 23   AEQPLSERAQYLQ---REHALLSEQLDTCEESVDQVLRENAFLDREALRLR---EENRLY 76
            AEQ  + RAQ  Q   R+      +++  ++  +Q LR+ A +++E   LR   EE    
Sbjct: 2120 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2179

Query: 77   ASYVSARAQRC---AKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLL----- 128
             + +    QR    A    R   Q   +L  +  Q  EL+ L    E   RA +L     
Sbjct: 2180 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2239

Query: 129  -------------EMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQL 175
                         ++   AA+++   QE    + L  E LA+ RAL  ++L  +++  Q 
Sbjct: 2240 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2299

Query: 176  LHRVK-----------------RRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQ 218
              R+K                 RR  EDK    ++  +  Q   R  E E  R L    +
Sbjct: 2300 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2359

Query: 219  AIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREHEDTRD 264
            A +    R+ +      R  +     R+Q  E  E+LHR    T++
Sbjct: 2360 AERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2404



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 60/259 (23%), Positives = 109/259 (42%), Gaps = 24/259 (9%)

Query: 19   AAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYAS 78
            A A AE+   E  Q +Q       E++   EE+     ++   +  E  +LR+ +     
Sbjct: 1360 AKAQAEREAKELQQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1412

Query: 79   YVSARAQRCAKAIVRLDEQNRVDLAQIH-------WQRAELASLYHGREDGVRAQLLEME 131
              + +A+   ++ +R++E+ RV   Q+            EL +L   R +   AQ  + +
Sbjct: 1413 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1471

Query: 132  ARAAQMAQQVQ-ELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAF 190
              A ++ +QVQ E Q  +  ++E  +R++A E E    +    Q L  ++ +  E     
Sbjct: 1472 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRALQALEELRLQAEE----A 1526

Query: 191  EREARQRVQSLARRAE---REAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQ 247
            ER  RQ     AR+ +     A R+  A  Q+ +A       +L   L+   +     R+
Sbjct: 1527 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1586

Query: 248  LLEQREQLHREHEDTRDLA 266
              E+R Q   E E  R+ A
Sbjct: 1587 EAERRAQQQAEAERAREEA 1605



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 66/271 (24%), Positives = 119/271 (43%), Gaps = 46/271 (16%)

Query: 29   ERAQYLQREHALLSEQLD--------TCEESVDQVLRENAFLDREALRLREENRLYASYV 80
            E+A+ LQ +   +++QL         T E    + L  +A  +R  LR+ E +R  A   
Sbjct: 2319 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-A 2377

Query: 81   SARAQRCAKAIVRLDEQ-NRVDLA-----------QIHWQRAE---------LASLYHGR 119
               AQR  K    + E+ +R +LA           +I  Q+++         +A L   +
Sbjct: 2378 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2437

Query: 120  ED-GVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR 178
            E     A+LL++++   Q  QQ Q LQ  + LQ   L+     E++ L  R    +    
Sbjct: 2438 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS-----EKDSLLQRERFIEQEKA 2492

Query: 179  VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIK----ADNG-RLRQELLL 233
               +  +D+ A  ++ R+  Q   ++ E+E  R + +  +A +    A+ G R +QE L 
Sbjct: 2493 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2552

Query: 234  LL-----RRTQLLHHTRRQLLEQREQLHREH 259
             L     ++ +LL    ++L EQ + L  +H
Sbjct: 2553 QLEQQRRQQEELLAEENQRLREQLQLLEEQH 2583



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 59/250 (23%), Positives = 95/250 (38%), Gaps = 37/250 (14%)

Query: 34   LQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVR 93
            LQ EH  +++  +  E    Q          EA R REE          +A    +  ++
Sbjct: 1574 LQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELERWQLKANEALRLRLQ 1625

Query: 94   LDE---QNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVL 150
             +E   Q  +  A+   Q+ E       RE   R +  E   R  ++A+Q  EL+  + L
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQ--ELEKQRQL 1678

Query: 151  QLEQLARIRALERELLHMRVE------HTQLLHRVKRRFLEDKAAFEREARQRVQSLAR- 203
                  +  A E+EL+ +R E        QLL     R   + AA  ++ ++    LA+ 
Sbjct: 1679 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1738

Query: 204  RAEREAVRALVAHT------------QAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQ 251
            RAE E + A  A              Q ++A+ GR R+      R   L    +RQ    
Sbjct: 1739 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1798

Query: 252  REQLHREHED 261
             E   R+  +
Sbjct: 1799 EEDAARQRAE 1808



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 65/264 (24%), Positives = 105/264 (39%), Gaps = 36/264 (13%)

Query: 18   AAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYA 77
            AAA  AE  L      L R  +   + L + E++  +  R+      E  R RE      
Sbjct: 1915 AAAGKAELELE-----LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1969

Query: 78   SYVSARAQRCAKAIVRLDEQNR----VDLAQIHWQRAELAS---LYHGREDGVRAQLLEM 130
              ++A  +   +    L+E  R    V+ A+   +RAE  S   L   +E   +    E 
Sbjct: 1970 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029

Query: 131  EARAAQMAQQVQELQPYKVLQLEQ-----------LARIRALERELLHMRVEHTQLLHR- 178
            +A A  + Q+ QELQ  + LQ EQ            AR  A E E   ++ E      R 
Sbjct: 2030 KAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2087

Query: 179  --VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLR 236
               +   L+  A  + +AR + Q+ A +  +EA +      Q   A+   LRQ+      
Sbjct: 2088 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQK---QAA 2141

Query: 237  RTQLLHHTR--RQLLEQREQLHRE 258
              ++  H +   Q L Q+ Q+ +E
Sbjct: 2142 DAEMEKHKKFAEQTLRQKAQVEQE 2165



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 35/141 (24%), Positives = 59/141 (41%), Gaps = 6/141 (4%)

Query: 28   SERAQYLQREHALLSEQL--DTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQ 85
            SE  Q +Q+E  L   Q    +     D +L+   F+++E  +L +   L+   V A+AQ
Sbjct: 2451 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ---LFQDEV-AKAQ 2506

Query: 86   RCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQ 145
            +  +   R  +Q   +  ++     E     H  E+GVR +  E++    Q  QQ + L 
Sbjct: 2507 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2566

Query: 146  PYKVLQLEQLARIRALERELL 166
                   EQL  +    R  L
Sbjct: 2567 EENQRLREQLQLLEEQHRAAL 2587



 Score = 33.5 bits (75), Expect = 0.39
 Identities = 61/261 (23%), Positives = 99/261 (37%), Gaps = 26/261 (9%)

Query: 25   QPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARA 84
            Q L E    LQRE A  +++    E  + +V  E   L     R  EE+R  +     R 
Sbjct: 1708 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1767

Query: 85   QRCAKAIVRLDEQN---RVDLAQIHWQR---AELASLYHGREDGVRAQLLEMEARAAQMA 138
            +  A     L E+    R    +   QR    E A+      + V A+ L     A ++ 
Sbjct: 1768 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1827

Query: 139  QQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR--VKRRFLEDKAAFEREARQ 196
             + +     K  + E+L R+ A +      R+E     H+  ++ R  + + A + E  +
Sbjct: 1828 TEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL-E 1885

Query: 197  RVQSLA------RRAEREAVRALVAHTQAIKADNGRLRQEL----------LLLLRRTQL 240
            R + L       RR   E + AL A  +   A    L  EL          L    + +L
Sbjct: 1886 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1945

Query: 241  LHHTRRQLLEQREQLHREHED 261
                +RQL  + E+  RE E+
Sbjct: 1946 EAARQRQLAAEEERRRREAEE 1966


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 68/286 (23%), Positives = 111/286 (38%), Gaps = 45/286 (15%)

Query: 23   AEQPLSERAQYLQ---REHALLSEQLDTCEESVDQVLRENAFLDREALRLR---EENRLY 76
            AEQ  + RAQ  Q   R+      +++  ++  +Q LR+ A +++E   LR   EE    
Sbjct: 2128 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2187

Query: 77   ASYVSARAQRC---AKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLL----- 128
             + +    QR    A    R   Q   +L  +  Q  EL+ L    E   RA +L     
Sbjct: 2188 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2247

Query: 129  -------------EMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQL 175
                         ++   AA+++   QE    + L  E LA+ RAL  ++L  +++  Q 
Sbjct: 2248 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2307

Query: 176  LHRVK-----------------RRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQ 218
              R+K                 RR  EDK    ++  +  Q   R  E E  R L    +
Sbjct: 2308 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2367

Query: 219  AIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREHEDTRD 264
            A +    R+ +      R  +     R+Q  E  E+LHR    T++
Sbjct: 2368 AERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2412



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 60/259 (23%), Positives = 109/259 (42%), Gaps = 24/259 (9%)

Query: 19   AAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYAS 78
            A A AE+   E  Q +Q       E++   EE+     ++   +  E  +LR+ +     
Sbjct: 1368 AKAQAEREAKELQQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1420

Query: 79   YVSARAQRCAKAIVRLDEQNRVDLAQIH-------WQRAELASLYHGREDGVRAQLLEME 131
              + +A+   ++ +R++E+ RV   Q+            EL +L   R +   AQ  + +
Sbjct: 1421 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1479

Query: 132  ARAAQMAQQVQ-ELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAF 190
              A ++ +QVQ E Q  +  ++E  +R++A E E    +    Q L  ++ +  E     
Sbjct: 1480 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRALQALEELRLQAEE----A 1534

Query: 191  EREARQRVQSLARRAE---REAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQ 247
            ER  RQ     AR+ +     A R+  A  Q+ +A       +L   L+   +     R+
Sbjct: 1535 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1594

Query: 248  LLEQREQLHREHEDTRDLA 266
              E+R Q   E E  R+ A
Sbjct: 1595 EAERRAQQQAEAERAREEA 1613



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 66/271 (24%), Positives = 119/271 (43%), Gaps = 46/271 (16%)

Query: 29   ERAQYLQREHALLSEQLD--------TCEESVDQVLRENAFLDREALRLREENRLYASYV 80
            E+A+ LQ +   +++QL         T E    + L  +A  +R  LR+ E +R  A   
Sbjct: 2327 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-A 2385

Query: 81   SARAQRCAKAIVRLDEQ-NRVDLA-----------QIHWQRAE---------LASLYHGR 119
               AQR  K    + E+ +R +LA           +I  Q+++         +A L   +
Sbjct: 2386 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2445

Query: 120  ED-GVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR 178
            E     A+LL++++   Q  QQ Q LQ  + LQ   L+     E++ L  R    +    
Sbjct: 2446 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS-----EKDSLLQRERFIEQEKA 2500

Query: 179  VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIK----ADNG-RLRQELLL 233
               +  +D+ A  ++ R+  Q   ++ E+E  R + +  +A +    A+ G R +QE L 
Sbjct: 2501 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2560

Query: 234  LL-----RRTQLLHHTRRQLLEQREQLHREH 259
             L     ++ +LL    ++L EQ + L  +H
Sbjct: 2561 QLEQQRRQQEELLAEENQRLREQLQLLEEQH 2591



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 59/250 (23%), Positives = 95/250 (38%), Gaps = 37/250 (14%)

Query: 34   LQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVR 93
            LQ EH  +++  +  E    Q          EA R REE          +A    +  ++
Sbjct: 1582 LQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELERWQLKANEALRLRLQ 1633

Query: 94   LDE---QNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVL 150
             +E   Q  +  A+   Q+ E       RE   R +  E   R  ++A+Q  EL+  + L
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQ--ELEKQRQL 1686

Query: 151  QLEQLARIRALERELLHMRVE------HTQLLHRVKRRFLEDKAAFEREARQRVQSLAR- 203
                  +  A E+EL+ +R E        QLL     R   + AA  ++ ++    LA+ 
Sbjct: 1687 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1746

Query: 204  RAEREAVRALVAHT------------QAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQ 251
            RAE E + A  A              Q ++A+ GR R+      R   L    +RQ    
Sbjct: 1747 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1806

Query: 252  REQLHREHED 261
             E   R+  +
Sbjct: 1807 EEDAARQRAE 1816



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 65/264 (24%), Positives = 105/264 (39%), Gaps = 36/264 (13%)

Query: 18   AAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYA 77
            AAA  AE  L      L R  +   + L + E++  +  R+      E  R RE      
Sbjct: 1923 AAAGKAELELE-----LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1977

Query: 78   SYVSARAQRCAKAIVRLDEQNR----VDLAQIHWQRAELAS---LYHGREDGVRAQLLEM 130
              ++A  +   +    L+E  R    V+ A+   +RAE  S   L   +E   +    E 
Sbjct: 1978 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2037

Query: 131  EARAAQMAQQVQELQPYKVLQLEQ-----------LARIRALERELLHMRVEHTQLLHR- 178
            +A A  + Q+ QELQ  + LQ EQ            AR  A E E   ++ E      R 
Sbjct: 2038 KAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2095

Query: 179  --VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLR 236
               +   L+  A  + +AR + Q+ A +  +EA +      Q   A+   LRQ+      
Sbjct: 2096 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQK---QAA 2149

Query: 237  RTQLLHHTR--RQLLEQREQLHRE 258
              ++  H +   Q L Q+ Q+ +E
Sbjct: 2150 DAEMEKHKKFAEQTLRQKAQVEQE 2173



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 35/141 (24%), Positives = 59/141 (41%), Gaps = 6/141 (4%)

Query: 28   SERAQYLQREHALLSEQL--DTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQ 85
            SE  Q +Q+E  L   Q    +     D +L+   F+++E  +L +   L+   V A+AQ
Sbjct: 2459 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ---LFQDEV-AKAQ 2514

Query: 86   RCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQ 145
            +  +   R  +Q   +  ++     E     H  E+GVR +  E++    Q  QQ + L 
Sbjct: 2515 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2574

Query: 146  PYKVLQLEQLARIRALERELL 166
                   EQL  +    R  L
Sbjct: 2575 EENQRLREQLQLLEEQHRAAL 2595



 Score = 33.5 bits (75), Expect = 0.39
 Identities = 61/261 (23%), Positives = 99/261 (37%), Gaps = 26/261 (9%)

Query: 25   QPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARA 84
            Q L E    LQRE A  +++    E  + +V  E   L     R  EE+R  +     R 
Sbjct: 1716 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1775

Query: 85   QRCAKAIVRLDEQN---RVDLAQIHWQR---AELASLYHGREDGVRAQLLEMEARAAQMA 138
            +  A     L E+    R    +   QR    E A+      + V A+ L     A ++ 
Sbjct: 1776 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1835

Query: 139  QQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR--VKRRFLEDKAAFEREARQ 196
             + +     K  + E+L R+ A +      R+E     H+  ++ R  + + A + E  +
Sbjct: 1836 TEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL-E 1893

Query: 197  RVQSLA------RRAEREAVRALVAHTQAIKADNGRLRQEL----------LLLLRRTQL 240
            R + L       RR   E + AL A  +   A    L  EL          L    + +L
Sbjct: 1894 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1953

Query: 241  LHHTRRQLLEQREQLHREHED 261
                +RQL  + E+  RE E+
Sbjct: 1954 EAARQRQLAAEEERRRREAEE 1974


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 68/286 (23%), Positives = 111/286 (38%), Gaps = 45/286 (15%)

Query: 23   AEQPLSERAQYLQ---REHALLSEQLDTCEESVDQVLRENAFLDREALRLR---EENRLY 76
            AEQ  + RAQ  Q   R+      +++  ++  +Q LR+ A +++E   LR   EE    
Sbjct: 2169 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2228

Query: 77   ASYVSARAQRC---AKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLL----- 128
             + +    QR    A    R   Q   +L  +  Q  EL+ L    E   RA +L     
Sbjct: 2229 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2288

Query: 129  -------------EMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQL 175
                         ++   AA+++   QE    + L  E LA+ RAL  ++L  +++  Q 
Sbjct: 2289 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2348

Query: 176  LHRVK-----------------RRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQ 218
              R+K                 RR  EDK    ++  +  Q   R  E E  R L    +
Sbjct: 2349 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2408

Query: 219  AIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREHEDTRD 264
            A +    R+ +      R  +     R+Q  E  E+LHR    T++
Sbjct: 2409 AERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2453



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 60/259 (23%), Positives = 109/259 (42%), Gaps = 24/259 (9%)

Query: 19   AAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYAS 78
            A A AE+   E  Q +Q       E++   EE+     ++   +  E  +LR+ +     
Sbjct: 1409 AKAQAEREAKELQQRMQ-------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1461

Query: 79   YVSARAQRCAKAIVRLDEQNRVDLAQIH-------WQRAELASLYHGREDGVRAQLLEME 131
              + +A+   ++ +R++E+ RV   Q+            EL +L   R +   AQ  + +
Sbjct: 1462 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1520

Query: 132  ARAAQMAQQVQ-ELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAF 190
              A ++ +QVQ E Q  +  ++E  +R++A E E    +    Q L  ++ +  E     
Sbjct: 1521 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRALQALEELRLQAEE----A 1575

Query: 191  EREARQRVQSLARRAE---REAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQ 247
            ER  RQ     AR+ +     A R+  A  Q+ +A       +L   L+   +     R+
Sbjct: 1576 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1635

Query: 248  LLEQREQLHREHEDTRDLA 266
              E+R Q   E E  R+ A
Sbjct: 1636 EAERRAQQQAEAERAREEA 1654



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 66/271 (24%), Positives = 119/271 (43%), Gaps = 46/271 (16%)

Query: 29   ERAQYLQREHALLSEQLD--------TCEESVDQVLRENAFLDREALRLREENRLYASYV 80
            E+A+ LQ +   +++QL         T E    + L  +A  +R  LR+ E +R  A   
Sbjct: 2368 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-A 2426

Query: 81   SARAQRCAKAIVRLDEQ-NRVDLA-----------QIHWQRAE---------LASLYHGR 119
               AQR  K    + E+ +R +LA           +I  Q+++         +A L   +
Sbjct: 2427 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2486

Query: 120  ED-GVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR 178
            E     A+LL++++   Q  QQ Q LQ  + LQ   L+     E++ L  R    +    
Sbjct: 2487 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS-----EKDSLLQRERFIEQEKA 2541

Query: 179  VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIK----ADNG-RLRQELLL 233
               +  +D+ A  ++ R+  Q   ++ E+E  R + +  +A +    A+ G R +QE L 
Sbjct: 2542 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2601

Query: 234  LL-----RRTQLLHHTRRQLLEQREQLHREH 259
             L     ++ +LL    ++L EQ + L  +H
Sbjct: 2602 QLEQQRRQQEELLAEENQRLREQLQLLEEQH 2632



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 59/250 (23%), Positives = 95/250 (38%), Gaps = 37/250 (14%)

Query: 34   LQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVR 93
            LQ EH  +++  +  E    Q          EA R REE          +A    +  ++
Sbjct: 1623 LQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELERWQLKANEALRLRLQ 1674

Query: 94   LDE---QNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVL 150
             +E   Q  +  A+   Q+ E       RE   R +  E   R  ++A+Q  EL+  + L
Sbjct: 1675 AEEVAQQKSLAQAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQ--ELEKQRQL 1727

Query: 151  QLEQLARIRALERELLHMRVE------HTQLLHRVKRRFLEDKAAFEREARQRVQSLAR- 203
                  +  A E+EL+ +R E        QLL     R   + AA  ++ ++    LA+ 
Sbjct: 1728 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1787

Query: 204  RAEREAVRALVAHT------------QAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQ 251
            RAE E + A  A              Q ++A+ GR R+      R   L    +RQ    
Sbjct: 1788 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1847

Query: 252  REQLHREHED 261
             E   R+  +
Sbjct: 1848 EEDAARQRAE 1857



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 65/264 (24%), Positives = 105/264 (39%), Gaps = 36/264 (13%)

Query: 18   AAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYA 77
            AAA  AE  L      L R  +   + L + E++  +  R+      E  R RE      
Sbjct: 1964 AAAGKAELELE-----LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2018

Query: 78   SYVSARAQRCAKAIVRLDEQNR----VDLAQIHWQRAELAS---LYHGREDGVRAQLLEM 130
              ++A  +   +    L+E  R    V+ A+   +RAE  S   L   +E   +    E 
Sbjct: 2019 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2078

Query: 131  EARAAQMAQQVQELQPYKVLQLEQ-----------LARIRALERELLHMRVEHTQLLHR- 178
            +A A  + Q+ QELQ  + LQ EQ            AR  A E E   ++ E      R 
Sbjct: 2079 KAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2136

Query: 179  --VKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLR 236
               +   L+  A  + +AR + Q+ A +  +EA +      Q   A+   LRQ+      
Sbjct: 2137 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQK---QAA 2190

Query: 237  RTQLLHHTR--RQLLEQREQLHRE 258
              ++  H +   Q L Q+ Q+ +E
Sbjct: 2191 DAEMEKHKKFAEQTLRQKAQVEQE 2214



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 35/141 (24%), Positives = 59/141 (41%), Gaps = 6/141 (4%)

Query: 28   SERAQYLQREHALLSEQL--DTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQ 85
            SE  Q +Q+E  L   Q    +     D +L+   F+++E  +L +   L+   V A+AQ
Sbjct: 2500 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ---LFQDEV-AKAQ 2555

Query: 86   RCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQ 145
            +  +   R  +Q   +  ++     E     H  E+GVR +  E++    Q  QQ + L 
Sbjct: 2556 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2615

Query: 146  PYKVLQLEQLARIRALERELL 166
                   EQL  +    R  L
Sbjct: 2616 EENQRLREQLQLLEEQHRAAL 2636



 Score = 33.5 bits (75), Expect = 0.39
 Identities = 61/261 (23%), Positives = 99/261 (37%), Gaps = 26/261 (9%)

Query: 25   QPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARA 84
            Q L E    LQRE A  +++    E  + +V  E   L     R  EE+R  +     R 
Sbjct: 1757 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1816

Query: 85   QRCAKAIVRLDEQN---RVDLAQIHWQR---AELASLYHGREDGVRAQLLEMEARAAQMA 138
            +  A     L E+    R    +   QR    E A+      + V A+ L     A ++ 
Sbjct: 1817 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1876

Query: 139  QQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHR--VKRRFLEDKAAFEREARQ 196
             + +     K  + E+L R+ A +      R+E     H+  ++ R  + + A + E  +
Sbjct: 1877 TEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL-E 1934

Query: 197  RVQSLA------RRAEREAVRALVAHTQAIKADNGRLRQEL----------LLLLRRTQL 240
            R + L       RR   E + AL A  +   A    L  EL          L    + +L
Sbjct: 1935 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1994

Query: 241  LHHTRRQLLEQREQLHREHED 261
                +RQL  + E+  RE E+
Sbjct: 1995 EAARQRQLAAEEERRRREAEE 2015


>gi|239752594 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 673

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 52/164 (31%), Positives = 79/164 (48%), Gaps = 17/164 (10%)

Query: 280 PLWERPAFSQPTSRPGSLAAPISPSRAA-SQTPSVVP-SRAAPRASSVVPSREA-SRVPS 336
           P W  P+ + PT  P +  A  SPSRAA ++TPS    +R   RAS   PSR + +R PS
Sbjct: 520 PTWT-PSTASPTGSPSTALAMGSPSRAALTRTPSRASLTRTPSRASLTTPSRASLTRTPS 578

Query: 337 LVLSSMDSRVPSLATSKVGSRMPSLTASRAGSRALSLVQSLEGSGISSGSSPRVSSQDTL 396
            VL    +R+P  A+    + MPS T S  G  + +L+  ++ +   + + PR S  +T 
Sbjct: 579 TVLL---TRMPPSASP---TGMPSRT-SPTGMPSSALLTKMDSTASITRTPPRASPTET- 630

Query: 397 RSTKSGPKLLSGLSRDRDPALLPPQ-SEDSVNAEAAAEASPGRA 439
              ++ P   +G      P   PP+ S       A+   +P RA
Sbjct: 631 -PPRASP---TGTPPRASPTGTPPRASPTGTPPRASPTGTPSRA 670



 Score = 36.6 bits (83), Expect = 0.046
 Identities = 43/163 (26%), Positives = 68/163 (41%), Gaps = 12/163 (7%)

Query: 284 RPAFSQPTSRPGSLAAPISPSRAA--SQTPSVVPSRAAPRASSVVPSREASRVPSLVLSS 341
           RP+ + PT  P   +  ++PS A+     P   P+    R S       AS   +   +S
Sbjct: 280 RPSTASPTGTPSRASLSMTPSTASLMRMLPRASPTGMLSRTSLTKMDSTASISRTPPRAS 339

Query: 342 MDSRVPSLA--TSKVGSRMPSLTASRA---GSRALSLVQSLEGSGISSGSSPRVSSQDTL 396
           + +R PS A  T K  +  P+ T SRA   GS + + +  L  +   +G+ PR S     
Sbjct: 340 I-TRTPSRASPTGKPSTASPTGTPSRASPTGSPSTASLTGLSSTASPTGTPPRASP---- 394

Query: 397 RSTKSGPKLLSGLSRDRDPALLPPQSEDSVNAEAAAEASPGRA 439
             T S   L     R     +L   S   +++ A+   +P RA
Sbjct: 395 TGTPSTASLTRKPPRASPTGMLSRTSITKMDSTASPTRTPPRA 437



 Score = 35.8 bits (81), Expect = 0.079
 Identities = 50/183 (27%), Positives = 74/183 (40%), Gaps = 16/183 (8%)

Query: 272 LRRGPGGPPLWERPAFSQPTSRPGSLAAPISPSRAA----------SQTPSVVP-SRAAP 320
           L R P    L   P+ +  +  P + AA   PSRA+          + TPS    +R  P
Sbjct: 121 LTRSPSRASLTTTPSRASLSMTPSTAAALTMPSRASLTRTPPRASLTMTPSTASLTRTPP 180

Query: 321 RASSV-VPSREA-SRVPSLV-LSSMDSRVPSLAT-SKVGSRMPSLTASRAGSRALSLVQS 376
           RAS   +PSR + + +PS   L+ MDS      T S+         AS  GS   + +  
Sbjct: 181 RASPTGMPSRTSPTGMPSTASLTKMDSTASITRTLSRASPTGTPPRASPTGSPPRASLSM 240

Query: 377 LEGSGISSGSSPRVSSQDTLRSTKSGPKLLSGLSRDRDPALLPPQSEDSVNAEAAAEASP 436
           +  + +   + PR S    L  T S  K+ S  S  R P+     S     + A+   +P
Sbjct: 241 MPSTALLIRTPPRASPTGMLSRT-SLTKMDSTASITRTPSRPSTASPTGTPSRASLSMTP 299

Query: 437 GRA 439
             A
Sbjct: 300 STA 302



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 48/183 (26%), Positives = 73/183 (39%), Gaps = 28/183 (15%)

Query: 285 PAFSQPTSRPGSLAAPISPSRAA-SQTPS--------------VVPSRAAPRASSVVPSR 329
           P+ + PT  P + +   SPSRA+ ++TPS                PSRA+P  +    S 
Sbjct: 470 PSTASPTGSPSTASPTGSPSRASLTRTPSRASLTKMESTASITRTPSRASPTWTPSTASP 529

Query: 330 EASRVPSLVLSSMD----SRVPSLAT-SKVGSRMPSLTASRAG-SRALSLV------QSL 377
             S   +L + S      +R PS A+ ++  SR    T SRA  +R  S V       S 
Sbjct: 530 TGSPSTALAMGSPSRAALTRTPSRASLTRTPSRASLTTPSRASLTRTPSTVLLTRMPPSA 589

Query: 378 EGSGISSGSSPRVSSQDTLRSTKSGPKLLSGLSRDRDPALLPPQ-SEDSVNAEAAAEASP 436
             +G+ S +SP       L +       ++       P   PP+ S       A+   +P
Sbjct: 590 SPTGMPSRTSPTGMPSSALLTKMDSTASITRTPPRASPTETPPRASPTGTPPRASPTGTP 649

Query: 437 GRA 439
            RA
Sbjct: 650 PRA 652



 Score = 34.3 bits (77), Expect = 0.23
 Identities = 43/145 (29%), Positives = 67/145 (46%), Gaps = 27/145 (18%)

Query: 280 PLWERPAFSQPTSRPGSLAAPISPSRAA-SQTPSV-----VPSRAA-----PRAS----- 323
           P    P+ + PT  P + +   +PSRA+ + TPS       PSRA+     PRAS     
Sbjct: 3   PPTRTPSRASPTRTPSTASLTGTPSRASLTGTPSTASLMGTPSRASLTGTPPRASLKGTT 62

Query: 324 ---SVVPSREASRVPSLVLSSMDSRVPSLATSKVGSRMPSLTASRAGSRALSLVQSLEGS 380
              S++ S   + +  +  SS+ +R PS+A+ K   RMP        SR  +L ++    
Sbjct: 63  SMASLMVSPSRASLTRMQSSSLLTRTPSMASLK---RMPP-----RASRTRTLPRASLMR 114

Query: 381 GISSGSSPRVSSQDTLRSTKSGPKL 405
             S+ S  R  S+ +L +T S   L
Sbjct: 115 RPSTASLTRSPSRASLTTTPSRASL 139



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 42/136 (30%), Positives = 57/136 (41%), Gaps = 18/136 (13%)

Query: 273 RRGPGGPPLWERPAFSQPTSRPGSLAAPISPSRAASQTPSVVPSRAAPRASSVVPSREA- 331
           R  P G P    P  +Q T+ P       SPS A   +P+  PS A+P  S   PSR + 
Sbjct: 445 RASPTGTPSRASPTGTQSTASPTG-----SPSTA---SPTGSPSTASPTGS---PSRASL 493

Query: 332 SRVPSLV-LSSMDSRVPSLAT-SKVGSRMPSLTASRAGSRALSLVQSLEGSGISSGSSPR 389
           +R PS   L+ M+S      T S+        TAS  GS + +L         S  +  R
Sbjct: 494 TRTPSRASLTKMESTASITRTPSRASPTWTPSTASPTGSPSTALAM----GSPSRAALTR 549

Query: 390 VSSQDTLRSTKSGPKL 405
             S+ +L  T S   L
Sbjct: 550 TPSRASLTRTPSRASL 565


>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
          Length = 2028

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 68/290 (23%), Positives = 124/290 (42%), Gaps = 54/290 (18%)

Query: 23  AEQPLSERAQYLQREHALLSEQLDTCE----ESVDQVLRENAFLDREALRLREENRLYAS 78
           + Q L   ++ L RE   L   ++T +      +  + +E   L+R    LRE +++ + 
Sbjct: 523 SNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSE 582

Query: 79  YVSARAQRCAKAIVRLDEQNRVDLAQIHWQRAEL-ASLYHGREDGVRAQLLEMEARAAQ- 136
                 ++  KA+ +   +    L+Q+ +++ +L   L   +E G RA+ LE E +  Q 
Sbjct: 583 ARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQE 642

Query: 137 ----MAQQVQELQPY-----------KVLQLEQLA-------------RIRALERELLHM 168
               +A++V  L+             + LQLE                ++  LER+   +
Sbjct: 643 ENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQL 702

Query: 169 RVEHTQLLHRVKR-RFLEDKAA-FEREARQR-------------VQSLARRAEREAVRAL 213
             E+ +L   V+  RF   K A  ERE +Q              +++L +++ER     L
Sbjct: 703 DAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSER-----L 757

Query: 214 VAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREHEDTR 263
               Q++ A+N RL+Q L     +TQ L     +L  +R+ L R+ E  R
Sbjct: 758 ELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALR 807



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 54/194 (27%), Positives = 94/194 (48%), Gaps = 19/194 (9%)

Query: 25  QPLSERAQYLQREHALLSEQLDTCEE---SVDQVLRENAFLDREALRLRE--ENRLYASY 79
           + L   +Q LQ E+  L + LDT +     ++ + R+N  LD E L LR   E   + S 
Sbjct: 662 EALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTST 721

Query: 80  VSARAQRCAKAIVRLDEQNR--VDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQM 137
             A+ +R  + + R  E+ R  VDL +   +++E   L +     V A+ L ++      
Sbjct: 722 KLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSY---QSVSAENLRLQQSLESS 778

Query: 138 AQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQR 197
           + + Q L+  ++ +LE  A  +AL R+L  +R+ + QL    K     D+ A E+E  Q 
Sbjct: 779 SHKTQTLES-ELGELE--AERQALRRDLEALRLANAQLEGAEK-----DRKALEQEVAQ- 829

Query: 198 VQSLARRAEREAVR 211
           ++   +  E+EA R
Sbjct: 830 LEKDKKLLEKEAKR 843



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 64/263 (24%), Positives = 109/263 (41%), Gaps = 36/263 (13%)

Query: 15   PGGAAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENR 74
            PG   A      + +RA  L+R +A L  +    +E +  +  +N     + L L++++ 
Sbjct: 1043 PGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSA 1102

Query: 75   LYASYVSARAQRCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARA 134
                + +    + AK         +V+ + +  Q A L + Y   ++   A+  E E+  
Sbjct: 1103 FLQEHNTTLQTQTAKL--------QVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQ 1154

Query: 135  AQMAQ-------QVQELQPYKVLQLEQLARIRALERE-----LLH--MRVEHTQLLHRVK 180
             Q  Q        +Q+ +    L   Q A   AL R+      LH  + +EH +L  R  
Sbjct: 1155 RQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGER-H 1213

Query: 181  RRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRTQL 240
               L+ KA  E E R++V +     EREA++           +N RLR E    L R   
Sbjct: 1214 GDMLKRKA--ELEEREKVLT----TEREALQQEQRTNALAMGENQRLRGE----LDRVNF 1263

Query: 241  LHHTRRQLLEQREQLHREHEDTR 263
            LHH   QL  + E+LH   ++ +
Sbjct: 1264 LHH---QLKGEYEELHAHTKELK 1283



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 69/306 (22%), Positives = 111/306 (36%), Gaps = 59/306 (19%)

Query: 18   AAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENR--- 74
            AA    +Q L E+ Q+L+ ++   S Q+ T ++    +   N  L  +  +L+ EN    
Sbjct: 1067 AALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLS 1126

Query: 75   -----LYASYVSARAQRCAK-----AIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVR 124
                 L A Y   +    AK     ++ R  EQ       +      L +L+  +     
Sbjct: 1127 SQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYE 1186

Query: 125  AQL------------LEME-----ARAAQMAQQVQELQPY-KVLQ-----LEQLARIRAL 161
            A +            LE+E      R   M ++  EL+   KVL      L+Q  R  AL
Sbjct: 1187 ALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNAL 1246

Query: 162  ---ERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQRVQSLARRAEREAVR------- 211
               E + L   ++    LH   +   E+  A  +E +  + +      R   R       
Sbjct: 1247 AMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQ 1306

Query: 212  ---------ALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQ----REQLHRE 258
                      L  H + +    G L +E   LL + QLL    + LLEQ    +EQ H E
Sbjct: 1307 HQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEE 1366

Query: 259  HEDTRD 264
             +   D
Sbjct: 1367 QKQYID 1372



 Score = 30.8 bits (68), Expect = 2.5
 Identities = 63/309 (20%), Positives = 123/309 (39%), Gaps = 53/309 (17%)

Query: 3   PKKKRGPSAGSQPGGAAAAGAEQP---------LSERAQYLQREHALLSEQLDTCEESVD 53
           P   +  SA S P   ++  +E              R + +++E    +EQL      VD
Sbjct: 226 PSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVD 285

Query: 54  QVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVRLDEQNRVDLAQIHWQRAE-- 111
           Q++ E   + +E ++L  + R      SARA R     +R ++ NRV+  ++   R +  
Sbjct: 286 QLVLELQKVKQENIQLAADAR------SARAYRDELDSLR-EKANRVERLELELTRCKEK 338

Query: 112 -------LASLYHGREDGV-----RAQLLEMEARAAQMAQQVQELQPYKV---LQLEQLA 156
                   A +   RED +     +A L E    A     +V EL+   +    +L  L 
Sbjct: 339 LHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLE 398

Query: 157 RIRALERELLHMRVEHTQLLHRVKRRFLEDKA--AFEREARQRVQSLARRAEREAVRAL- 213
             R  +++ +   +E   +L   +++ + + A   +E E   +   L+  + +  V  L 
Sbjct: 399 LDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELN 458

Query: 214 -VAHTQAIKAD-NGRLRQELLLLLRRTQLL---------------HHTRRQLLEQREQLH 256
             A ++ +K +   +  Q  +  LR   L+               H   +++ + + QL 
Sbjct: 459 ECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLE 518

Query: 257 REHEDTRDL 265
           RE +  +DL
Sbjct: 519 REKQSNQDL 527


>gi|171906567 peripheral benzodiazepine receptor-associated protein
           1 isoform b [Homo sapiens]
          Length = 1797

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 81/317 (25%), Positives = 123/317 (38%), Gaps = 44/317 (13%)

Query: 29  ERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCA 88
           E+ Q +Q+  + LS++   CE    +  ++    +   L+LR+     A  V   ++   
Sbjct: 272 EKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSG 331

Query: 89  KAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYK 148
           +A          +  Q+ W+ AEL           R QLL +        ++ Q LQ  K
Sbjct: 332 RA---------TEKEQVEWENAEL-----------RGQLLGVTQERDSALRKSQGLQS-K 370

Query: 149 VLQLEQ-LARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQRVQSLARRAER 207
           +  LEQ L  +R + +    + VEH Q      R  L +K   E    Q+ Q+ A+R   
Sbjct: 371 LESLEQVLKHMREVAQRRQQLEVEHEQ-----ARLSLREKQE-EVRRLQQAQAEAQREHE 424

Query: 208 EAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREHEDTRDL-- 265
            AV+ L +   +++A    L ++      R+Q     +  LL Q  Q  R H    DL  
Sbjct: 425 GAVQLLESTLDSMQARVRELEEQC-----RSQT---EQFSLLAQELQAFRLHPGPLDLLT 476

Query: 266 -ARVHGWLRRGPGGPPLWERPAFSQPTSRPGSLAAPISPSRAASQTPSVVPSRAAPRASS 324
            A   G L   P  P     P   QP    G     + P      TP    S  AP   +
Sbjct: 477 SALDCGSLGDCPPPPCCCSIP---QPCRGSGPKDLDLPPGSPGRCTPK--SSEPAPATLT 531

Query: 325 VVPSREASRVPSLVLSS 341
            VP R A +  SL  SS
Sbjct: 532 GVPRRTAKKAESLSNSS 548


>gi|171906559 peripheral benzodiazepine receptor-associated protein
           1 isoform a [Homo sapiens]
          Length = 1857

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 81/317 (25%), Positives = 123/317 (38%), Gaps = 44/317 (13%)

Query: 29  ERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCA 88
           E+ Q +Q+  + LS++   CE    +  ++    +   L+LR+     A  V   ++   
Sbjct: 332 EKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSG 391

Query: 89  KAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYK 148
           +A          +  Q+ W+ AEL           R QLL +        ++ Q LQ  K
Sbjct: 392 RA---------TEKEQVEWENAEL-----------RGQLLGVTQERDSALRKSQGLQS-K 430

Query: 149 VLQLEQ-LARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQRVQSLARRAER 207
           +  LEQ L  +R + +    + VEH Q      R  L +K   E    Q+ Q+ A+R   
Sbjct: 431 LESLEQVLKHMREVAQRRQQLEVEHEQ-----ARLSLREKQE-EVRRLQQAQAEAQREHE 484

Query: 208 EAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREHEDTRDL-- 265
            AV+ L +   +++A    L ++      R+Q     +  LL Q  Q  R H    DL  
Sbjct: 485 GAVQLLESTLDSMQARVRELEEQC-----RSQT---EQFSLLAQELQAFRLHPGPLDLLT 536

Query: 266 -ARVHGWLRRGPGGPPLWERPAFSQPTSRPGSLAAPISPSRAASQTPSVVPSRAAPRASS 324
            A   G L   P  P     P   QP    G     + P      TP    S  AP   +
Sbjct: 537 SALDCGSLGDCPPPPCCCSIP---QPCRGSGPKDLDLPPGSPGRCTPK--SSEPAPATLT 591

Query: 325 VVPSREASRVPSLVLSS 341
            VP R A +  SL  SS
Sbjct: 592 GVPRRTAKKAESLSNSS 608


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 57/261 (21%), Positives = 113/261 (43%), Gaps = 23/261 (8%)

Query: 13   SQPGGAAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREE 72
            SQ    + A A++ L  R +  QR  A L ++  T   ++++  ++   L R    L E+
Sbjct: 784  SQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQ 843

Query: 73   NRLYASYVSARAQRCAKAIVRLDEQNRVDLAQIHWQ--------RAELASLYHGREDGVR 124
             RL    +     R  K + ++ E ++  L Q+  Q        R E+A      +D   
Sbjct: 844  KRL----LDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWA- 898

Query: 125  AQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRA-LERELLHMRVEHTQLLHRVKRRF 183
            ++  +     +++  ++Q L+  + LQ  Q  R  A L++ELL  R++  +     K+R 
Sbjct: 899  SEAEKTSGGLSRLQDEIQRLR--QALQASQAERDTARLDKELLAQRLQGLEQEAENKKRS 956

Query: 184  LEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHH 243
             +D+A   +   ++V  L    + E       +T  +  D     ++ +  LR   +   
Sbjct: 957  QDDRARQLKGLEEKVSRLETELDEE------KNTVELLTDRVNRGRDQVDQLRTELMQER 1010

Query: 244  TRRQLLE-QREQLHREHEDTR 263
            + RQ LE  +  L R+++D +
Sbjct: 1011 SARQDLECDKISLERQNKDLK 1031



 Score = 37.7 bits (86), Expect = 0.021
 Identities = 53/188 (28%), Positives = 85/188 (45%), Gaps = 34/188 (18%)

Query: 93  RLDEQ----NRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYK 148
           +LDE+     +++ +Q+  +R     L    E+  R Q L +E R  +  Q  +ELQ  K
Sbjct: 374 KLDEEVKKRQKLEPSQVGLER----QLEEKTEECSRLQEL-LERRKGEAQQSNKELQNMK 428

Query: 149 VLQLEQLARIR-ALERELLHM--RVEHTQLLHRVKRRFLEDKAAFER------EARQRVQ 199
            L L+Q   +R  LE +++ +  +++H Q     K   L+D            E +QRV+
Sbjct: 429 RL-LDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVE 487

Query: 200 SLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREH 259
              R  ERE           + A  G L++E+     R Q + H R+Q     EQL R  
Sbjct: 488 EQLRLRERE-----------LTALKGALKEEVA---SRDQEVEHVRQQYQRDTEQLRRSM 533

Query: 260 ED-TRDLA 266
           +D T+D A
Sbjct: 534 QDATQDHA 541



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 61/254 (24%), Positives = 106/254 (41%), Gaps = 32/254 (12%)

Query: 30  RAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAK 89
           R + L+++ A+L  + D   E  +Q L+    L +   +LR++        +++A+  A+
Sbjct: 658 RDRELEKQLAVLRVEADRGRELEEQNLQ----LQKTLQQLRQDCE-----EASKAKMVAE 708

Query: 90  AIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEM-------EARAAQMAQQVQ 142
           A   +  Q R  +     +  E    +  R  G+  QL E        EA  A++  ++Q
Sbjct: 709 AEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQ 768

Query: 143 ELQPYKVLQLEQLARIR-------ALERELLHMRVEHTQL-LHRVKRRFLEDKAAFEREA 194
            L+  K  QLE+            A  +  L  R+E  Q  L R+ +       A E E 
Sbjct: 769 RLEAEKQ-QLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEG 827

Query: 195 RQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRT-QLLHHTRRQLLEQRE 253
           +QR      +AE E  + L+  T        RL +EL  +   + Q L   + QL + +E
Sbjct: 828 KQREVLRRGKAELEEQKRLLDRTV------DRLNKELEKIGEDSKQALQQLQAQLEDYKE 881

Query: 254 QLHREHEDTRDLAR 267
           +  RE  D +  A+
Sbjct: 882 KARREVADAQRQAK 895


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.127    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,481,347
Number of Sequences: 37866
Number of extensions: 790453
Number of successful extensions: 8586
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 101
Number of HSP's successfully gapped in prelim test: 778
Number of HSP's that attempted gapping in prelim test: 6560
Number of HSP's gapped (non-prelim): 2344
length of query: 439
length of database: 18,247,518
effective HSP length: 105
effective length of query: 334
effective length of database: 14,271,588
effective search space: 4766710392
effective search space used: 4766710392
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.