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Search of human proteins with 24111244
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24111244 MAM domain containing glycosylphosphatidylinositol
anchor 1 [Homo sapiens]
(955 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24111244 MAM domain containing glycosylphosphatidylinositol a... 1950 0.0
gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens] 1039 0.0
gi|38158013 MAM domain containing 1 isoform 2 [Homo sapiens] 719 0.0
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 166 7e-41
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 142 1e-33
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 139 1e-32
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 139 1e-32
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 137 5e-32
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 134 5e-31
gi|118572606 hemicentin 1 [Homo sapiens] 129 1e-29
gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Ho... 125 2e-28
gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Ho... 124 3e-28
gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Ho... 124 3e-28
gi|7657359 contactin 5 isoform long [Homo sapiens] 120 5e-27
gi|28373129 contactin 5 isoform short [Homo sapiens] 120 5e-27
gi|75709184 contactin 3 [Homo sapiens] 120 8e-27
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 117 4e-26
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 117 5e-26
gi|110349719 titin isoform N2-A [Homo sapiens] 116 1e-25
gi|109150416 peroxidasin [Homo sapiens] 114 4e-25
gi|139948432 adlican [Homo sapiens] 113 7e-25
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 110 8e-24
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 109 1e-23
gi|205277425 immunoglobulin superfamily, member 9 isoform a [Hom... 108 2e-23
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [... 107 5e-23
gi|7657361 contactin 6 [Homo sapiens] 102 1e-21
gi|205277423 immunoglobulin superfamily, member 9 isoform b [Hom... 101 3e-21
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens] 99 1e-20
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens] 99 1e-20
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens] 99 1e-20
>gi|24111244 MAM domain containing glycosylphosphatidylinositol
anchor 1 [Homo sapiens]
Length = 955
Score = 1950 bits (5051), Expect = 0.0
Identities = 955/955 (100%), Positives = 955/955 (100%)
Query: 1 MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQC 60
MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQC
Sbjct: 1 MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQC 60
Query: 61 LVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIK 120
LVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIK
Sbjct: 61 LVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIK 120
Query: 121 SIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQ 180
SIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQ
Sbjct: 121 SIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQ 180
Query: 181 DNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPP 240
DNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPP
Sbjct: 181 DNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPP 240
Query: 241 ALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQA 300
ALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQA
Sbjct: 241 ALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQA 300
Query: 301 RDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVD 360
RDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVD
Sbjct: 301 RDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVD 360
Query: 361 AVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP 420
AVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP
Sbjct: 361 AVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP 420
Query: 421 GAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDK 480
GAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDK
Sbjct: 421 GAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDK 480
Query: 481 EAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE 540
EAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE
Sbjct: 481 EAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE 540
Query: 541 VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAEL 600
VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAEL
Sbjct: 541 VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAEL 600
Query: 601 RLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVL 660
RLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVL
Sbjct: 601 RLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVL 660
Query: 661 QWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR 720
QWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR
Sbjct: 661 QWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR 720
Query: 721 LTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALT 780
LTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALT
Sbjct: 721 LTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALT 780
Query: 781 QNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHM 840
QNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHM
Sbjct: 781 QNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHM 840
Query: 841 YGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGY 900
YGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGY
Sbjct: 841 YGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGY 900
Query: 901 LGDIAIDDVTLKKGECPRKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQR 955
LGDIAIDDVTLKKGECPRKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQR
Sbjct: 901 LGDIAIDDVTLKKGECPRKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQR 955
>gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens]
Length = 956
Score = 1039 bits (2687), Expect = 0.0
Identities = 495/921 (53%), Positives = 667/921 (72%), Gaps = 17/921 (1%)
Query: 8 LLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPR 67
LL ++ GQGVYAP +IVH+G AC ++E+ SERVYTIREG+TL L CLVTGHPR
Sbjct: 10 LLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPR 69
Query: 68 PQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQ 127
PQ+RWTKTAGSASD+FQ++SVFNETLRI I R QGGRYYCKAENG+G PAIKSIRVDV
Sbjct: 70 PQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVY 129
Query: 128 YLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIY 187
YLD+P++TVHQ++ + + FY E+TVFLRC NSNPP R+ W+RG + L D GV+IY
Sbjct: 130 YLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIY 189
Query: 188 EPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVN 247
EP +TQGETK+LKLKNLRPQDYA+Y+C SVRNVC IPDK ++FRL+N TA P++KL V+
Sbjct: 190 EPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVD 249
Query: 248 ETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYN 307
+ +VVNPGE +T+ C+ TGG+P P L W G LP + GGTL+IP++ + D+G Y+
Sbjct: 250 DPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYS 309
Query: 308 CTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKV 367
C A NNVGNPAKK+ N++VR++K F ITPD + +NIQ+G+++K+SC V+AVP E++
Sbjct: 310 CIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEEL 369
Query: 368 TYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDL 427
T+ WFKNG+P R S+R+++T+ DP++ T++L++IDL F+D+GTY C+AS G + D+
Sbjct: 370 TFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDI 429
Query: 428 SVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPS 487
S++VNISS TVPP ++VP+ ++ + REG ELQC+V GKP+P +LWSR DKE A +P
Sbjct: 430 SIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVA-MPD 488
Query: 488 GLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQD 547
G E+ DG LR+ VSR+MSG YRCQT++YNGFNV+PREA VQL VQ+PP VEP+ +
Sbjct: 489 GSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLE 548
Query: 548 VRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTR 607
+RQ R V + C +LR P R+ + WR +LL ++ ++ E + +++
Sbjct: 549 IRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLR-----TGQFDSQEYTEYAVKSLSN 603
Query: 608 DSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREP 667
++ G Y CS+ N+ G+ C F V+ KAY+PEFY+DT NP ++ + YSY LQWTQ P
Sbjct: 604 ENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNR-HRVYSYSLQWTQMNP 662
Query: 668 DAVDPVLNYRLSIRQLNQHNAVVKAIPVR-RVEKGQLLEYILTDLRVPHSYEVRLTPYTT 726
DAVD ++ YRL IRQ Q + I + ++KG+L+ Y LT+L P +YEVRLTP T
Sbjct: 663 DAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTK 722
Query: 727 FGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRS 786
FG GD R+I Y+ P+N P+L + C FED IC +TQD TDNFDWT+Q+ T+N K +
Sbjct: 723 FGEGDSTIRVIKYSAPVN-PHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYT 781
Query: 787 PNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAK--------FYCVSFFY 838
PNTGP D SG+ EG+YM+IETSRPR G++ARL+SP+++ + K YC SFFY
Sbjct: 782 PNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFY 841
Query: 839 HMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGP 898
HMYG+HIG LN+ +R + + ++ WS SGNKG W +AHV I P FQ+IFEG+RGP
Sbjct: 842 HMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGP 901
Query: 899 GYLGDIAIDDVTLKKGECPRK 919
G GDIAIDDV++ +GEC ++
Sbjct: 902 GIEGDIAIDDVSIAEGECAKQ 922
>gi|38158013 MAM domain containing 1 isoform 2 [Homo sapiens]
Length = 727
Score = 719 bits (1857), Expect = 0.0
Identities = 345/700 (49%), Positives = 488/700 (69%), Gaps = 17/700 (2%)
Query: 229 ITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALA 288
++FRL+N TA P++KL V++ +VVNPGE +T+ C+ TGG+P P L W G LP +
Sbjct: 2 VSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVL 61
Query: 289 QGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQ 348
GGTL+IP++ + D+G Y+C A NNVGNPAKK+ N++VR++K F ITPD + +NIQ
Sbjct: 62 NGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQ 121
Query: 349 LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFS 408
+G+++K+SC V+AVP E++T+ WFKNG+P R S+R+++T+ DP++ T++L++IDL F+
Sbjct: 122 IGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFT 181
Query: 409 DYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGK 468
D+GTY C+AS G + D+S++VNISS TVPP ++VP+ ++ + REG ELQC+V GK
Sbjct: 182 DFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGK 241
Query: 469 PRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPRE 528
P+P +LWSR DKE A +P G E+ DG LR+ VSR+MSG YRCQT++YNGFNV+PRE
Sbjct: 242 PKPIILWSRADKEVA-MPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPRE 300
Query: 529 AQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVV 588
A VQL VQ+PP VEP+ ++RQ R V + C +LR P R+ + WR +LL
Sbjct: 301 ALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLR----- 355
Query: 589 PAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTR 648
++ ++ E + +++ ++ G Y CS+ N+ G+ C F V+ KAY+PEFY+DT NP
Sbjct: 356 TGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVW 415
Query: 649 SHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVR-RVEKGQLLEYI 707
++ + YSY LQWTQ PDAVD ++ YRL IRQ Q + I + ++KG+L+ Y
Sbjct: 416 QNR-HRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYN 474
Query: 708 LTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDL 767
LT+L P +YEVRLTP T FG GD R+I Y+ P+N P+L + C FED IC +TQD
Sbjct: 475 LTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYSAPVN-PHLREFHCGFEDGNICLFTQDD 533
Query: 768 TDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNA 827
TDNFDWT+Q+ T+N K +PNTGP D SG+ EG+YM+IETSRPR G++ARL+SP+++
Sbjct: 534 TDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSI 593
Query: 828 SAK--------FYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAH 879
+ K YC SFFYHMYG+HIG LN+ +R + + ++ WS SGNKG W +AH
Sbjct: 594 APKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAH 653
Query: 880 VPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRK 919
V I P FQ+IFEG+RGPG GDIAIDDV++ +GEC ++
Sbjct: 654 VNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQ 693
Score = 111 bits (278), Expect = 3e-24
Identities = 106/381 (27%), Positives = 167/381 (43%), Gaps = 38/381 (9%)
Query: 50 IREGDTLMLQCLVTG-HPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYC 108
+ G+ + L C+ TG P P + W ++ G+ +K T + TL I I G Y C
Sbjct: 25 VNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEK---TVLNGGTLTIPAITSDDAGTYSC 81
Query: 109 KAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPAR-- 166
A N VG PA KS + V+ L + + N + V + C V + P
Sbjct: 82 IANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELT 141
Query: 167 FIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPD 226
F W + L S+ + +P + G T L + +L+ D+ +YTC S++ GI D
Sbjct: 142 FSWFKNGRPLRSSERMVITQTDPDVSPGTTN-LDIIDLKFTDFGTYTCVASLKG-GGISD 199
Query: 227 KAITFRLTNTTAPPALKLSVNET-LVVNPGENVTVQCLLTGGDPLPQLQWSHGPG--PLP 283
+I ++++T PP L + ++ LV G+ + +QC +T G P P + WS +P
Sbjct: 200 ISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVT-GKPKPIILWSRADKEVAMP 258
Query: 284 LGAL---AQGGTLSIPSVQARDSGYYNCTATNNVG---NPAKKTVNLLVRSMKNATFQIT 337
G++ + GTL I +V SG Y C + G P + V L+V Q
Sbjct: 259 DGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIV--------QYP 310
Query: 338 PDVIKESENIQLGQD--LKLSCHV-DAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELP 394
P V I+ GQD + +SC V A P +TY+W R+ +LL T
Sbjct: 311 PAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEW-------RLGNKLLRTGQFDSQE 363
Query: 395 AVTSSLELIDLHFSDYGTYLC 415
+++ L +YG Y C
Sbjct: 364 YTEYAVK--SLSNENYGVYNC 382
Score = 62.0 bits (149), Expect = 3e-09
Identities = 49/177 (27%), Positives = 82/177 (46%), Gaps = 30/177 (16%)
Query: 51 REGDTLMLQCLVTGHPRPQVRWTKTAGSAS--DKFQETSVFNETLRIERIARTQGGRYYC 108
REGDT+ LQC VTG P+P + W++ + D + ++ TLRI ++R G Y C
Sbjct: 227 REGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRC 286
Query: 109 KAE--NGVGV-PAIKSIRVDVQY---LDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSN 162
+ NG V P +++ VQY ++ L + Q Q+++V + C V
Sbjct: 287 QTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQG---------QDRSVTMSCRVLRA 337
Query: 163 PPARFI---WKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQV 216
P R + W+ G+ L Q + + YT+ +K+L ++Y Y C +
Sbjct: 338 YPIRVLTYEWRLGNKLLRTGQFDSQE-----YTE-----YAVKSLSNENYGVYNCSI 384
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 166 bits (421), Expect = 7e-41
Identities = 170/626 (27%), Positives = 260/626 (41%), Gaps = 105/626 (16%)
Query: 46 RVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGR 105
RV + G+ L L C+ G+P PQ+ W+K + + SV +R + GR
Sbjct: 1127 RVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSVHFAAIR-----TSDAGR 1181
Query: 106 YYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQT---VSDVRGNFYQEKTVFLRCTVNSN 162
Y C+A N GV A + V+++ L+ P +T + V G + L C
Sbjct: 1182 YRCEASNSAGVDAWE---VELRVLEPPHWGADETSGLLERVAG-----ENASLPCPARGT 1233
Query: 163 PPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLK-----LKNLRPQDYASYTCQVS 217
P + W++G + EPL+ Q VL+ L ++ P D Y CQ +
Sbjct: 1234 PKPQVTWRKGPSS------------EPLHGQPGVAVLEEGSLFLASVSPADSGDYECQAT 1281
Query: 218 VRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVN-PGENVTVQCLLTGGDPLPQLQWS 276
N G + + PP+++ + V G+++T++C G P+P++ W
Sbjct: 1282 --NEVGSTSRRAKLVV---YVPPSIREDGRKANVSGMAGQSLTLEC-DANGFPVPEIVWL 1335
Query: 277 HGPG--PLPLG-----------------ALAQGGTLSIPSVQARDSGYYNCTATNNVGNP 317
+PLG L +G +L P +Q DSG Y+C A N G
Sbjct: 1336 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGT- 1394
Query: 318 AKKTVNLLVRSMKNATFQITPDVIKESENIQ-----LGQDLKLSCHVDAVPQEKVTYQWF 372
A++ +LLV +TP + + Q G D++L C VP +V +W
Sbjct: 1395 AQRDFHLLV---------LTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQV--EWT 1443
Query: 373 KNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP-GAPVPDLSVEV 431
K+ +P L + D ++ +T S H D G Y C+A P G D + V
Sbjct: 1444 KDRQPVLPGGPHLQVQEDGQVLRITGS------HVGDEGRYQCVAFSPAGQQARDFQLRV 1497
Query: 432 NISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPL 491
+ PPTI V V E +L CE RG P P + W K+ ALLP+ +
Sbjct: 1498 H-----APPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWF---KDGALLPTSTKV 1549
Query: 492 EETPDGK-LRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSS---QD 547
T G+ L+L R +G Y C+ + G E +L+V PP +E +
Sbjct: 1550 VYTRGGRQLQLGRAQSSDAGVYTCKASNAVG----AAEKATRLDVYVPPTIEGAGGRPYV 1605
Query: 548 VRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTR 607
V+ GRPV L C + RG P S W +G LP + E D + LRL++
Sbjct: 1606 VKAVAGRPVALEC-VARGHPSPTLS--WHHEG--LPVAESNESRLET-DGSVLRLESPGE 1659
Query: 608 DSSGSYECSVSNDVGSAACLFQVSAK 633
SSG Y C S+ G A + V +
Sbjct: 1660 ASSGLYSCVASSPAGEAVLQYSVEVQ 1685
Score = 139 bits (351), Expect = 1e-32
Identities = 166/602 (27%), Positives = 238/602 (39%), Gaps = 84/602 (13%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF--NETLRIERIARTQGGRYY 107
+R GD +L C P P V W K G Q T + L I+ + G Y
Sbjct: 3044 VRVGDKAVLSCETDALPEPTVTWYKD-GQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYS 3102
Query: 108 CKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARF 167
CK N G A+++ + VQ +TVS V G+ + L C V+ P
Sbjct: 3103 CKVSNVAG-EAVRTFTLTVQVPPTFENPKTETVSQVAGS-----PLVLTCDVSGVPAPTV 3156
Query: 168 IWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDK 227
W + + S +GV ++G L+L L+P +YTC D
Sbjct: 3157 TWLKDRMPVESSAVHGV------VSRGGR--LQLSRLQPAQAGTYTCVAENTQAEARKD- 3207
Query: 228 AITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPL----- 282
F + AP V V G+ V + C G P P + W PL
Sbjct: 3208 ---FVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC-EADGQPPPDVAWLKDGSPLGQDMG 3263
Query: 283 -PLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAK-KTVNLLVRSMKNATFQITPDV 340
L GG+L + ++A D+G Y C A N G A+ TVN+LV P
Sbjct: 3264 PHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV-----------PPT 3312
Query: 341 IKESEN------IQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELP 394
IK+ + + G+ + + C V P V+ W K+G P +S+R L L
Sbjct: 3313 IKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVS--WLKDGLPLPLSQRTL-------LH 3363
Query: 395 AVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVR 454
+L + + +D G + C+A+ P A V D + + + VPP + + + V V
Sbjct: 3364 GSGHTLRISKVQLADAGIFTCVAASP-AGVADRNFTLQVQ---VPPVLEPVEFQNDVVVV 3419
Query: 455 EGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRC 514
GS EL CE RG P P V W + D E L S LE+ P L+LE V SGTY C
Sbjct: 3420 RGSLVELPCEARGVPLPLVSWMK-DGEPLLSQS---LEQGP--SLQLEAVGAGDSGTYSC 3473
Query: 515 QTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQAL--GRPVLLRCSLLRGSPQRIAS 572
G QL V PP +E S Q +L G P+ L C +G+PQ +
Sbjct: 3474 VAVSEAG----EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCD-AQGTPQ--PN 3526
Query: 573 AVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSA 632
W GQ A +++ RD +G Y C + G+ F+V
Sbjct: 3527 ITWHKDGQ---------ALTRLENNSRATRVLRVRD-AGLYTCLAESPAGAIEKSFRVRV 3576
Query: 633 KA 634
+A
Sbjct: 3577 QA 3578
Score = 137 bits (345), Expect = 5e-32
Identities = 154/581 (26%), Positives = 231/581 (39%), Gaps = 61/581 (10%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTKT-AGSASDKFQETSVFNETLRIERIARTQGGRYY 107
T+ G+T +L C V G + W + + + + + +L I I T GGRY
Sbjct: 527 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 586
Query: 108 CKAENGVGVPAIKSIRVDVQYL--DEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPA 165
C A N GV R V L + P +++H + +F Q V + C+ + P
Sbjct: 587 CVASNANGVT-----RASVWLLVREAPQVSIHTSSQ----HFSQGVEVKVSCSASGYPTP 637
Query: 166 RFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIP 225
W R S L VD L QG + P+D +Y+CQ + N G
Sbjct: 638 HISWSRESQALQEDSRIHVDAQGTLIIQG---------VAPEDAGNYSCQAT--NEVGTD 686
Query: 226 DKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG 285
+ +T T+ PP++ +VN ++V GE + C +G P P++ W G + L
Sbjct: 687 QETVTLYYTD---PPSVS-AVNAVVLVAVGEEAVLVCEASGVPP-PRVIWYRGGLEMILA 741
Query: 286 AL-AQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKES 344
+ G L IP+ Q RD+G Y C A N +G+ A + L V T ++ DV
Sbjct: 742 PEGSSSGKLRIPAAQERDAGTYTCRAVNELGD-ASAEIQLAVGHAPQLT-ELPRDV---- 795
Query: 345 ENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELID 404
++LG+ L+C P VT+ + G + RL R + L
Sbjct: 796 -TVELGRSALLACRATGRPPPTVTW---RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFES 851
Query: 405 LHFSDYGTYLCMASFPGAPVPDLSVEVN-ISSETVPPTISVPKGRAVVTVREGSPAELQC 463
+ D Y+C A V E I + PP I+ V V EG P L C
Sbjct: 852 VAPEDQAPYVCEARNVFGKV---QAEARLIVTGHAPPQIA--SSAPTVRVLEGQPVSLPC 906
Query: 464 EV-RGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGF 522
V G+P P W K+ LP G DG L L+R ++ +G Y C G
Sbjct: 907 IVLAGRPLPERHWL---KDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGS 963
Query: 523 NVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW-RFKGQL 581
R V+L VQ PP + P++ G P L C + G P + W + L
Sbjct: 964 QHR----DVELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVP--APTITWTKETNAL 1016
Query: 582 LPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVG 622
P + E L + + +G+Y C+ +N VG
Sbjct: 1017 TSRGPHYNVSKE----GTLLIAQPSAQDAGAYVCTATNTVG 1053
Score = 137 bits (344), Expect = 6e-32
Identities = 165/612 (26%), Positives = 236/612 (38%), Gaps = 89/612 (14%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQE-TSVFNE-TLRIERIARTQGGRYYCKA 110
G+ L C G P+PQV W K S Q +V E +L + ++ G Y C+A
Sbjct: 1221 GENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQA 1280
Query: 111 ENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWK 170
N VG S R + P + ++V G Q T L C N P +W
Sbjct: 1281 TNEVGST---SRRAKLVVYVPPSIREDGRKANVSGMAGQSLT--LECDANGFPVPEIVWL 1335
Query: 171 RGSDTLS-------HSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCG 223
+ + + + D G E + L ++ D Y+C+ N G
Sbjct: 1336 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAE--NQAG 1393
Query: 224 IPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGP-L 282
+ F L T P L + ++ G +V +QC T G P PQ++W+ P L
Sbjct: 1394 TAQR--DFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCW-TSGVPTPQVEWTKDRQPVL 1450
Query: 283 PLGALAQ----GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQI-- 336
P G Q G L I D G Y C A + G A+ FQ+
Sbjct: 1451 PGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARD-------------FQLRV 1497
Query: 337 -TPDVI---KESENIQLGQD--LKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRND 390
P I E+ + + +D ++L C VP +T WFK+G S +++ TR
Sbjct: 1498 HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT--WFKDGALLPTSTKVVYTRGG 1555
Query: 391 PELPAVTSSLELIDLHFSDYGTYLCMASFP-GAPVPDLSVEVNISSETVPPTISVPKGRA 449
+L +L SD G Y C AS GA ++V VPPTI GR
Sbjct: 1556 RQL-------QLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY-----VPPTIEGAGGRP 1603
Query: 450 -VVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKL-------RL 501
VV G P L+C RG P P + W GLP+ E+ + +L RL
Sbjct: 1604 YVVKAVAGRPVALECVARGHPSPTLSWHH---------EGLPVAESNESRLETDGSVLRL 1654
Query: 502 ERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE--VEPSSQDVRQALGRPVLLR 559
E SG Y C + G V Q + VQ PP+ V V +G+P+ L
Sbjct: 1655 ESPGEASSGLYSCVASSPAGEAV----LQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELP 1710
Query: 560 CSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSN 619
C GSP + + W G+ P + A L +D V D SG + C +N
Sbjct: 1711 CQA-SGSP--VPTIQWLQNGR---PAEELAGVQVASQGTTLHIDHVELDHSGLFACQATN 1764
Query: 620 DVGSAACLFQVS 631
+ G+A +VS
Sbjct: 1765 EAGTAGAEVEVS 1776
Score = 131 bits (329), Expect = 3e-30
Identities = 159/595 (26%), Positives = 237/595 (39%), Gaps = 67/595 (11%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQET-SVFNETLRIERIARTQGGRYYC 108
+ E ++ L+CL +G P P V W K S T SV LRIE+ + G Y C
Sbjct: 1897 VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRC 1956
Query: 109 KAENGVGVPAIK-SIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARF 167
A N G ++ +RV+V P +T+ ++ G V L C P
Sbjct: 1957 VASNVAGSTELRYGLRVNV----PPRITLPPSLP---GPVLVNTPVRLTCNATGAPSPTL 2009
Query: 168 IWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDK 227
+W + + +S + G+ ++ +VL L + R D Y+C V + +
Sbjct: 2010 MWLKDGNPVSPAGTPGLQVFP------GGRVLTLASARASDSGRYSCVA----VSAVGED 2059
Query: 228 AITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP---- 283
L P L +N ++V N E+V ++C + P P L W PL
Sbjct: 2060 RQDVVLQVHMPPSILGEELNVSVVAN--ESVALEC-QSHAMPPPVLSWWKDGRPLEPRPG 2116
Query: 284 LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKE 343
+ A L + D+G+Y C A N G+ ++K NL V + P
Sbjct: 2117 VHLSADKALLQVDRADVWDAGHYTCEALNQAGH-SEKHYNLNV-----WVAPVFPLRESH 2170
Query: 344 SENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELI 403
+ ++ G LSC VP K++ W K+G+P L + AV L L
Sbjct: 2171 TLTVREGHPTSLSCECRGVPFPKIS--WRKDGQPLPGEGAGL-----QHVSAVGRLLYLG 2223
Query: 404 DLHFSDYGTYLCMAS-FPGAPVPDLSVEVNISSETVPPTISVPKGRAV-VTVREGSPAEL 461
+ GTY C S G DL +EV+ VPP I+ P+ V+V + A L
Sbjct: 2224 QAQLAQEGTYTCECSNVVGNSSQDLQLEVH-----VPPQIAGPREPPTQVSVVQDGVATL 2278
Query: 462 QCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNG 521
+C GKP P V W R D + GL L+ L +ER +G Y C G
Sbjct: 2279 ECNATGKPPPTVTWER-DGQPVGAELGLQLQNQGQ-SLHVERAQAAHTGRYSCVAENLAG 2336
Query: 522 FNVRPREAQVQLNVQFPPE----VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRF 577
E + +L+V PPE ++P + ++ AL P+ L C + P I W F
Sbjct: 2337 ----RAERKFELSVLVPPELIGDLDPLT-NITAALHSPLTLLCEAMGIPPPAIR---W-F 2387
Query: 578 KGQLLPPPPVVPAAAE--APDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQV 630
+G+ PV P L++ SG Y C SN+ G A F V
Sbjct: 2388 RGE----EPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSV 2438
Score = 129 bits (324), Expect = 1e-29
Identities = 167/645 (25%), Positives = 244/645 (37%), Gaps = 128/645 (19%)
Query: 47 VYTIREGDTLMLQCLVTGHPRPQVRWTKTA--------GSASDKFQETSVFNETLRIERI 98
V + G+ +L C +G P P+V W + GS+S K LRI
Sbjct: 706 VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK----------LRIPAA 755
Query: 99 ARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCT 158
G Y C+A N +G A I++ V + P LT + DV ++ L C
Sbjct: 756 QERDAGTYTCRAVNELG-DASAEIQLAVGHA--PQLT--ELPRDVTVEL--GRSALLACR 808
Query: 159 VNSNPPARFIWKRGSDT---LSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQ 215
PP W+RG L G +P ++ VL +++ P+D A Y C+
Sbjct: 809 ATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQP-----DSGVLFFESVAPEDQAPYVCE 863
Query: 216 VSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQW 275
RNV G +T APP + S T+ V G+ V++ C++ G PLP+ W
Sbjct: 864 A--RNVFGKVQAEARLIVTGH-APPQIASSA-PTVRVLEGQPVSLPCIVLAGRPLPERHW 919
Query: 276 SHGPGPLPLG---ALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLV----RS 328
PLP G ++ G+L + +G Y+C ATN G+ + V L+V R
Sbjct: 920 LKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGS-QHRDVELVVQVPPRI 978
Query: 329 MKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPAR-----MSKR 383
AT IT + G L C VP +T+ N +R +SK
Sbjct: 979 HPTATHHITNE----------GVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKE 1028
Query: 384 --LLVTRNDPE---------------------------------------LPAVTSSLEL 402
LL+ + + LP + SL L
Sbjct: 1029 GTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLP--SGSLRL 1086
Query: 403 IDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQ 462
+ D G Y C AS P V VPP V G V+ V G +L
Sbjct: 1087 AQVQVGDSGHYECTASNPAGSASHRYV----LGVQVPP--QVQPGPRVLKVLVGEALDLN 1140
Query: 463 CEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGF 522
C G P P + WS K+ +L P G + + +G YRC+ + G
Sbjct: 1141 CVAEGNPEPQLSWS---KDGVVLQG-----RGPQGSVHFAAIRTSDAGRYRCEASNSAGV 1192
Query: 523 NVRPREAQVQLNVQFPPE--VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQ 580
+ +V+L V PP + +S + + G L C RG+P+ WR KG
Sbjct: 1193 DA----WEVELRVLEPPHWGADETSGLLERVAGENASLPCP-ARGTPK--PQVTWR-KGP 1244
Query: 581 LLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAA 625
P P A + L L +V+ SG YEC +N+VGS +
Sbjct: 1245 SSEPLHGQPGVA-VLEEGSLFLASVSPADSGDYECQATNEVGSTS 1288
Score = 125 bits (314), Expect = 2e-28
Identities = 164/596 (27%), Positives = 240/596 (40%), Gaps = 85/596 (14%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE-TLRIERIARTQGGRYYCKAE 111
G L+L C V+G P P V W K V L++ R+ Q G Y C AE
Sbjct: 3139 GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAE 3198
Query: 112 NGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKR 171
N A K V V L P + + + + + V L C + PP W +
Sbjct: 3199 N-TQAEARKDFVVAV--LVAPRIRSSGVARE--HHVLEGQEVRLDCEADGQPPPDVAWLK 3253
Query: 172 GSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITF 231
L QD G + Y G + VLK LR D +YTC N G + T
Sbjct: 3254 DGSPLG--QDMGPHLR--FYLDGGSLVLK--GLRASDAGAYTCVA--HNPAGEDARLHT- 3304
Query: 232 RLTNTTAPPALKLSVNE--TLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALA- 288
N PP +K + TLV PGE VT+ C + G P+ + W PLPL
Sbjct: 3305 --VNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPI-HVSWLKDGLPLPLSQRTL 3361
Query: 289 ---QGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQI-TPDVIK-- 342
G TL I VQ D+G + C A + G + +N T Q+ P V++
Sbjct: 3362 LHGSGHTLRISKVQLADAGIFTCVAASPAGV-----------ADRNFTLQVQVPPVLEPV 3410
Query: 343 ESEN---IQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSS 399
E +N + G ++L C VP V+ W K+G+P L++++ + P S
Sbjct: 3411 EFQNDVVVVRGSLVELPCEARGVPLPLVS--WMKDGEP-------LLSQSLEQGP----S 3457
Query: 400 LELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSP 458
L+L + D GTY C+A S G + V PP I +++ G+P
Sbjct: 3458 LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV-----MEPPHIEDSGQPTELSLTPGAP 3512
Query: 459 AELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTAR 518
EL C+ +G P+P + W + + L E R+ RV RD +G Y C
Sbjct: 3513 MELLCDAQGTPQPNITWHKDGQALTRL-------ENNSRATRVLRV-RD-AGLYTCLAES 3563
Query: 519 YNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRP---VLLRCSLLRGSPQRIASAVW 575
G E ++ VQ PP + + R +G ++L CS+ +I W
Sbjct: 3564 PAG----AIEKSFRVRVQAPPNIV-GPRGPRFVVGLAPGQLVLECSVEAEPAPKIT---W 3615
Query: 576 RFKGQLLPPPPVVPAAAEAPDHAE-LRLDAVTRDSSGSYECSVSNDVGSAACLFQV 630
G +L A + P+ L+L A++ SG Y C+ N GS + F+V
Sbjct: 3616 HRDGIVLQED----AHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRV 3667
Score = 124 bits (312), Expect = 3e-28
Identities = 150/619 (24%), Positives = 232/619 (37%), Gaps = 69/619 (11%)
Query: 14 FHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWT 73
+ C + A A+ V A + R + + EG + L C G P P V W
Sbjct: 3193 YTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWL 3252
Query: 74 KTAGSASDKFQETSVF---NETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVD-VQYL 129
K F +L ++ + + G Y C A N PA + R+ V L
Sbjct: 3253 KDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHN----PAGEDARLHTVNVL 3308
Query: 130 DEPMLTVHQTVSDVRGNFYQE--KTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIY 187
P T+ Q +D G + V + C V +PP W + L SQ
Sbjct: 3309 VPP--TIKQG-ADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRT----- 3360
Query: 188 EPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALK-LSV 246
G L++ ++ D +TC + + G+ D+ T ++ PP L+ +
Sbjct: 3361 ---LLHGSGHTLRISKVQLADAGIFTCVAA--SPAGVADRNFTLQVQ---VPPVLEPVEF 3412
Query: 247 NETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYY 306
+VV G V + C G PLP + W PL +L QG +L + +V A DSG Y
Sbjct: 3413 QNDVVVVRGSLVELPCEARGV-PLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTY 3471
Query: 307 NCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEK 366
+C A + G A++ L V + P + ++ G ++L C PQ
Sbjct: 3472 SCVAVSEAGE-ARRHFQLTVMEPPHIEDSGQPTEL----SLTPGAPMELLCDAQGTPQPN 3526
Query: 367 VTYQWFKNGKP-ARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVP 425
+T W K+G+ R+ TR L D G Y C+A P +
Sbjct: 3527 IT--WHKDGQALTRLENNSRATR---------------VLRVRDAGLYTCLAESPAGAI- 3568
Query: 426 DLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALL 485
+ S V + + PP I P+G V L+C V +P P + W R + +L
Sbjct: 3569 EKSFRVRVQA---PPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR---DGIVL 3622
Query: 486 PSGLPLEETPDGK-LRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPS 544
+ G+ L+L+ +S SG Y C G ++ + P +
Sbjct: 3623 QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAG----STSVAFRVEIHTVPTIRSG 3678
Query: 545 SQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDA 604
V ++ + LL C G P + S WR +P P P P+ LR+
Sbjct: 3679 PPAVNVSVNQTALLPCQ-ADGVPAPLVS--WR--KDRVPLDPRSPRFEILPE-GSLRIQP 3732
Query: 605 VTRDSSGSYECSVSNDVGS 623
V +G Y C SN GS
Sbjct: 3733 VLAQDAGHYLCLASNSAGS 3751
Score = 123 bits (309), Expect = 7e-28
Identities = 164/614 (26%), Positives = 237/614 (38%), Gaps = 85/614 (13%)
Query: 55 TLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF----NETLRIERIARTQGGRYYCKA 110
++ L C V HP P+V W K + + S VF TL++ R + G Y C+A
Sbjct: 2954 SVSLPCDVHAHPNPEVTWYKDSQALS---LGEEVFLLPGTHTLQLGRARLSDSGMYTCEA 3010
Query: 111 ENGVGVPAIKSIRVDV-------QYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNP 163
N G K +++ V Q P V V D L C ++ P
Sbjct: 3011 LNAAGRDQ-KLVQLSVLVPPAFRQAPRGPQDAVLVRVGD---------KAVLSCETDALP 3060
Query: 164 PARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCG 223
W + L +Q +G + L+++ + D Y+C+VS NV G
Sbjct: 3061 EPTVTWYKDGQPLVLAQRTQA-------LRGGQR-LEIQEAQVSDKGLYSCKVS--NVAG 3110
Query: 224 IPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP 283
+ TF LT PP + ET+ G + + C ++G P P + W P+
Sbjct: 3111 --EAVRTFTLT-VQVPPTFENPKTETVSQVAGSPLVLTCDVSGV-PAPTVTWLKDRMPVE 3166
Query: 284 L----GALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPD 339
G +++GG L + +Q +G Y C A N K V ++ + + I
Sbjct: 3167 SSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPR-----IRSS 3221
Query: 340 VIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTS- 398
+ ++ GQ+++L C D P V W K+G P P L
Sbjct: 3222 GVAREHHVLEGQEVRLDCEADGQPPPDVA--WLKDGSPLGQDM-------GPHLRFYLDG 3272
Query: 399 -SLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISV-PKGRAVVTVREG 456
SL L L SD G Y C+A P L VN+ VPPTI G + R G
Sbjct: 3273 GSLVLKGLRASDAGAYTCVAHNPAGEDARLHT-VNV---LVPPTIKQGADGSGTLVSRPG 3328
Query: 457 SPAELQCEVRGKPRPPVLWSRVDKEAALLP-SGLPLEETPDGKLRLERVSRDMSGTYRCQ 515
+ C VRG P V W K+ LP S L LR+ +V +G + C
Sbjct: 3329 ELVTMVCPVRGSPPIHVSWL---KDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCV 3385
Query: 516 TARYNGFNVRPREAQVQLNVQFPPEVEPSS--QDVRQALGRPVLLRCSLLRGSPQRIASA 573
A G R L VQ PP +EP DV G V L C RG P + S
Sbjct: 3386 AASPAGVADR----NFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEA-RGVPLPLVS- 3439
Query: 574 VWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
W G+ P + + + P L+L+AV SG+Y C ++ G A FQ++
Sbjct: 3440 -WMKDGE----PLLSQSLEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT-- 3489
Query: 634 AYSPEFYFDTPNPT 647
P D+ PT
Sbjct: 3490 VMEPPHIEDSGQPT 3503
Score = 121 bits (304), Expect = 3e-27
Identities = 143/552 (25%), Positives = 214/552 (38%), Gaps = 72/552 (13%)
Query: 83 FQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSD 142
FQE+ N + I R ++ + G Y C A + G K+ V + + + TVS
Sbjct: 473 FQESG--NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSP 530
Query: 143 VRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLK 202
+T L C V P W R L S + + L++
Sbjct: 531 -------GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD--------LSLEIS 575
Query: 203 NLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQC 262
+ P D Y C S N G+ +A + L ++ S + G V V C
Sbjct: 576 GIIPTDGGRYQCVAS--NANGVT-RASVWLLVREAPQVSIHTSSQH---FSQGVEVKVSC 629
Query: 263 LLTGGDPLPQLQWSHGPGPLPLGA---LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAK 319
+G P P + WS L + + GTL I V D+G Y+C ATN VG +
Sbjct: 630 SASGY-PTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD-Q 687
Query: 320 KTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPAR 379
+TV L + + + + +G++ L C VP +V W++ G
Sbjct: 688 ETVTLYYTDPPSVS------AVNAVVLVAVGEEAVLVCEASGVPPPRVI--WYRGGLEMI 739
Query: 380 MSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVP 439
++ PE + + L + D GTY C A + D S E+ ++ P
Sbjct: 740 LA---------PE-GSSSGKLRIPAAQERDAGTYTCRAV---NELGDASAEIQLAVGHAP 786
Query: 440 PTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPL-------E 492
+P+ VTV G A L C G+P P V W R D + P GL L
Sbjct: 787 QLTELPRD---VTVELGRSALLACRATGRPPPTVTWRRGDGQ----PLGLRLGAGRGSRS 839
Query: 493 ETPD-GKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQA 551
PD G L E V+ + Y C+ N F EA++ + PP++ S+ VR
Sbjct: 840 RQPDSGVLFFESVAPEDQAPYVCEAR--NVFGKVQAEARLIVTGHAPPQIASSAPTVRVL 897
Query: 552 LGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSG 611
G+PV L C +L G P + W G+ LPP A+ L LD ++ +G
Sbjct: 898 EGQPVSLPCIVLAGRP--LPERHWLKDGRPLPPGSRHSIRAD----GSLHLDRALQEHAG 951
Query: 612 SYECSVSNDVGS 623
Y C +N GS
Sbjct: 952 RYSCVATNTAGS 963
Score = 120 bits (301), Expect = 6e-27
Identities = 167/635 (26%), Positives = 245/635 (38%), Gaps = 98/635 (15%)
Query: 37 VVKEDNISE---RVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE-- 91
+ K+D + E + + TL L+C P P +RW K G V E
Sbjct: 2635 ISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKD-GQPVTPSSRLQVLGEGR 2693
Query: 92 TLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNF---- 147
L+I+ + GRY C A N G + V +Q PM Q V D F
Sbjct: 2694 LLQIQPTQVSDSGRYLCVATNVAGEDD-QDFNVLIQV--PPMF---QKVGDFSAAFEILS 2747
Query: 148 -----------YQE----KTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYT 192
Y+E +L C N+ PP W R LS + V
Sbjct: 2748 REEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV-------L 2800
Query: 193 QGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPAL--KLSVNETL 250
QG +VL++ +R ++ Y+C+ S + + + + L T P L + E +
Sbjct: 2801 QGG-RVLQIPLVRAENAGRYSCKASNE----VGEDWLHYELLVLTPPVILGDTEELVEEV 2855
Query: 251 VVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP----LGALAQGGTLSIPSVQARDSGYY 306
VN V++QC G +P+P + W P L L G L + + + D+ Y
Sbjct: 2856 TVNASSTVSLQCPALG-NPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASY 2914
Query: 307 NCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIK---ESENIQLGQDLKLSCHVDAVP 363
C A N G+ A+K L V Q+ P + E L + L C V A P
Sbjct: 2915 MCVAENQAGS-AEKLFTLRV--------QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHP 2965
Query: 364 QEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAP 423
+VT W+K+ + + + + + LP T +L+L SD G Y C A A
Sbjct: 2966 NPEVT--WYKDSQALSLGEEVFL------LPG-THTLQLGRARLSDSGMYTCEA-LNAAG 3015
Query: 424 VPDLSVEVNISSETVPPTI-SVPKG-RAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKE 481
V++++ VPP P+G + V VR G A L CE P P V W + +
Sbjct: 3016 RDQKLVQLSV---LVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQP 3072
Query: 482 AALLPSGLPLEETPDGKLRLERVSRDMS--GTYRCQTARYNGFNVRPREAQVQLNVQFPP 539
L L G RLE +S G Y C+ + G VR L VQ PP
Sbjct: 3073 LVLAQRTQALR----GGQRLEIQEAQVSDKGLYSCKVSNVAGEAVR----TFTLTVQVPP 3124
Query: 540 EVE-PSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAE--APD 596
E P ++ V Q G P++L C + G P A V K ++ PV +A
Sbjct: 3125 TFENPKTETVSQVAGSPLVLTCD-VSGVP---APTVTWLKDRM----PVESSAVHGVVSR 3176
Query: 597 HAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVS 631
L+L + +G+Y C N A F V+
Sbjct: 3177 GGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVA 3211
Score = 117 bits (293), Expect = 5e-26
Identities = 154/601 (25%), Positives = 224/601 (37%), Gaps = 89/601 (14%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTA-----GSASDKFQETSVFNETLRIERIARTQGGRYY 107
G + LQC +G P PQV WTK G + QE + LRI GRY
Sbjct: 1423 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDG---QVLRITGSHVGDEGRYQ 1479
Query: 108 CKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARF 167
C A + G A D Q T+ + ++ V L C P
Sbjct: 1480 CVAFSPAGQQAR-----DFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI 1534
Query: 168 IWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDK 227
W + L S + +YT+G + L+L + D YTC+ S N G +K
Sbjct: 1535 TWFKDGALLPTST-------KVVYTRGGRQ-LQLGRAQSSDAGVYTCKAS--NAVGAAEK 1584
Query: 228 AITFRLTNTTAPPALKLSVNETLVVNP--GENVTVQCLLTGGDPLPQLQWSHGPGPLPLG 285
A + PP ++ + VV G V ++C+ G P P L W H P+
Sbjct: 1585 ATRL---DVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG-HPSPTLSWHHEGLPVAES 1640
Query: 286 ALAQ----GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVI 341
++ G L + S SG Y+C A++ G + + Q+ P ++
Sbjct: 1641 NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQY---------SVEVQVPPQLL 1691
Query: 342 KESENIQL----GQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVT 397
Q+ GQ L+L C P T QW +NG+PA + V T
Sbjct: 1692 VAEGLGQVTTIVGQPLELPCQASGSPVP--TIQWLQNGRPAEELAGVQVASQ-----GTT 1744
Query: 398 SSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGS 457
++ ++L S G + C A+ A VEV++ E P + VP G+ S
Sbjct: 1745 LHIDHVELDHS--GLFACQATNE-AGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHS 1801
Query: 458 PAELQCEV---RG---KPRPPV---------LWSRVDKEAALLPSGLPLEETPDGKLRLE 502
C+ RG P+PP+ LW P+G+P+ + L++E
Sbjct: 1802 SFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGE--------PTGIPVAYSLPPPLQIE 1853
Query: 503 RVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSL 562
+V G Y C G + R +V L V PP +EP + V L C L
Sbjct: 1854 KVDLRDEGIYTCAATNLAGESKR----EVALKVLVPPNIEPGPVNKAVLENASVTLEC-L 1908
Query: 563 LRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVG 622
G P S W FKG P + D LR++ +GSY C SN G
Sbjct: 1909 ASGVPPPDVS--W-FKGH--QPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG 1963
Query: 623 S 623
S
Sbjct: 1964 S 1964
Score = 114 bits (286), Expect = 3e-25
Identities = 154/605 (25%), Positives = 225/605 (37%), Gaps = 79/605 (13%)
Query: 47 VYTIREG---------DTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE-TLRIE 96
V TIR G T +L C G P P V W K + + E +LRI+
Sbjct: 3672 VPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQ 3731
Query: 97 RIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLR 156
+ G Y C A N G D++ L+ P + + + + L
Sbjct: 3732 PVLAQDAGHYLCLASNSAGSDRQGR---DLRVLEPPAIAPSPSNLTLTAH----TPALLP 3784
Query: 157 CTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQV 216
C + +P +W + L G Y + L L PQD A + C V
Sbjct: 3785 CEASGSPKPLVVWWKDGQKLDFRLQQGA------YRLLPSNALLLTAPGPQDSAQFECVV 3838
Query: 217 SVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWS 276
S N G +A PP + + V V + C TG P P + WS
Sbjct: 3839 S--NEVG---EAHRLYQVTVHVPPTIADDQTDFTVTMMAP-VVLTCHSTG-IPAPTVSWS 3891
Query: 277 HGPGPLPLGALAQG------GTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMK 330
L GA G G L I +G Y C+A N+ G A K V L V++
Sbjct: 3892 KAGAQL--GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAG-VAHKHVFLTVQA-- 3946
Query: 331 NATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRND 390
+ + P V++ +++ L C +P+ +T W K G V
Sbjct: 3947 SPVVKPLPSVVRAVAE----EEVLLPCEASGIPRPTIT--WQKEGLNVATGVSTQV---- 3996
Query: 391 PELPAVTSSLELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISVPKGRA 449
LP L + D G YLC+A + G+ + + V VPP I G
Sbjct: 3997 --LPG--GQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQ-----VPPVIE--NGLP 4045
Query: 450 VVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMS 509
++ EGS A L C+ RG P P + W + + + ++ P G+L ++ + +
Sbjct: 4046 DLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQ--PSGELLVKNLEGQDA 4103
Query: 510 GTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSP-Q 568
GTY C G R R +V L + P D LG + LRC+ RGSP
Sbjct: 4104 GTYTCTAENAVG---RARR-RVHLTILVLPVFTTLPGDRSLRLGDRLWLRCA-ARGSPTP 4158
Query: 569 RIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLF 628
RI G + PV +E + L+ AV+R+ SG+Y C N VG +
Sbjct: 4159 RI--------GWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVS 4210
Query: 629 QVSAK 633
V K
Sbjct: 4211 FVHVK 4215
Score = 114 bits (285), Expect = 4e-25
Identities = 133/507 (26%), Positives = 195/507 (38%), Gaps = 78/507 (15%)
Query: 148 YQEKTVFLRCTVNSNPPARFIWKRGSDTLS---HSQDNGVDIYEPLYTQGETKVLKLKNL 204
Y + + + C+V+S P R +RG L H Q++G +E L
Sbjct: 439 YLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRAS----------- 487
Query: 205 RPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLL 264
+ +Y C R G I T PP L + N T V+PGE + C +
Sbjct: 488 -KAEEGTYECTAVSRAGTGRAKAQIVV----TDPPPQLVPAPNVT--VSPGETAVLSCRV 540
Query: 265 TGGDPLPQLQWSHGPGPLPL--GALAQGGTLS--IPSVQARDSGYYNCTATNNVGNPAKK 320
G P L W LP G +AQ LS I + D G Y C A+N G +
Sbjct: 541 LGEAPY-NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG-VTRA 598
Query: 321 TVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARM 380
+V LLVR + + S++ G ++K+SC P ++ W + + +
Sbjct: 599 SVWLLVREAPQVSIHTS------SQHFSQGVEVKVSCSASGYPTPHIS--WSRESQALQE 650
Query: 381 SKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETV-- 438
R+ V +L + + D G Y C A+ EV ETV
Sbjct: 651 DSRIHVDAQ--------GTLIIQGVAPEDAGNYSCQATN----------EVGTDQETVTL 692
Query: 439 ----PPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEET 494
PP++S AVV V G A L CE G P P V+W R E L P G +
Sbjct: 693 YYTDPPSVSAVN--AVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG-----S 745
Query: 495 PDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGR 554
GKLR+ +GTY C+ G A++QL V P++ +DV LGR
Sbjct: 746 SSGKLRIPAAQERDAGTYTCRAVNELG----DASAEIQLAVGHAPQLTELPRDVTVELGR 801
Query: 555 PVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAA----AEAPDHAELRLDAVTRDSS 610
LL C R + + + WR +G P + A + PD L ++V +
Sbjct: 802 SALLAC---RATGRPPPTVTWR-RGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQ 857
Query: 611 GSYECSVSNDVGSAACLFQVSAKAYSP 637
Y C N G ++ ++P
Sbjct: 858 APYVCEARNVFGKVQAEARLIVTGHAP 884
Score = 113 bits (283), Expect = 7e-25
Identities = 151/591 (25%), Positives = 225/591 (38%), Gaps = 119/591 (20%)
Query: 52 EGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAE 111
+G + + C +G+P P + W++ + + + + TL I+ +A G Y C+A
Sbjct: 621 QGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQAT 680
Query: 112 NGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKR 171
N VG V + Y D P ++ V V + L C + PP R IW R
Sbjct: 681 NEVGTD---QETVTLYYTDPPSVSAVNAVVLVAVG----EEAVLVCEASGVPPPRVIWYR 733
Query: 172 GSDTLSHSQDNGVDIYEPLYTQGETK-VLKLKNLRPQDYASYTCQVSVRNVCGIPDKAIT 230
G G+++ L +G + L++ + +D +YTC R V + D +
Sbjct: 734 G----------GLEMI--LAPEGSSSGKLRIPAAQERDAGTYTC----RAVNELGDASAE 777
Query: 231 FRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGP---LPLGA- 286
+L AP +L + T V G + + C TG P P + W G G L LGA
Sbjct: 778 IQLAVGHAPQLTELPRDVT--VELGRSALLACRATGRPP-PTVTWRRGDGQPLGLRLGAG 834
Query: 287 ------LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDV 340
G L SV D Y C A N G + L+V T P +
Sbjct: 835 RGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGK-VQAEARLIV------TGHAPPQI 887
Query: 341 IKESENIQL--GQDLKLSCHVDA---VPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPA 395
+ +++ GQ + L C V A +P+ W K+G+P R + +
Sbjct: 888 ASSAPTVRVLEGQPVSLPCIVLAGRPLPER----HWLKDGRPLPPGSRHSIRAD------ 937
Query: 396 VTSSLELIDLHFSDYGTYLCMAS-FPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVR 454
SL L G Y C+A+ G+ D+ + V VPP I P +T
Sbjct: 938 --GSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ-----VPPRIH-PTATHHIT-N 988
Query: 455 EGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRC 514
EG PA L C G P P + W++ + AL G + +G L + + S +G Y C
Sbjct: 989 EGVPASLPCVASGVPAPTITWTK--ETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVC 1046
Query: 515 QTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAV 574
GF SSQ++R ++ R L + V
Sbjct: 1047 TATNTVGF---------------------SSQEMRLSVNRLAL-------------SKYV 1072
Query: 575 WRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAA 625
W G LLP LRL V SG YEC+ SN GSA+
Sbjct: 1073 WEEYG-LLPS-------------GSLRLAQVQVGDSGHYECTASNPAGSAS 1109
Score = 111 bits (278), Expect = 3e-24
Identities = 151/597 (25%), Positives = 235/597 (39%), Gaps = 95/597 (15%)
Query: 48 YTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF-NETLRIERIARTQGGRY 106
+T+ ++L C TG P P V W+K + V + L I + GRY
Sbjct: 3866 FTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRY 3925
Query: 107 YCKAENGVGVPAIKSIRVDVQY--LDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPP 164
C A N GV A K + + VQ + +P+ +V + V+ E+ V L C + P
Sbjct: 3926 TCSARNSAGV-AHKHVFLTVQASPVVKPLPSVVRAVA--------EEEVLLPCEASGIPR 3976
Query: 165 ARFIWKRGSDTLSHSQDNGVDIYEPLYTQ----GETKVLKLKNLRPQDYASYTCQVSVRN 220
W Q G+++ + TQ G+ L++ + P+D +Y C +N
Sbjct: 3977 PTITW----------QKEGLNVATGVSTQVLPGGQ---LRIAHASPEDAGNYLC--IAKN 4021
Query: 221 VCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPG 280
G A+ PP ++ + + L G + + C G P P + W
Sbjct: 4022 SAG---SAMGKTRLVVQVPPVIENGLPD-LSTTEGSHAFLPCKARGS-PEPNITWDKDGQ 4076
Query: 281 PLPLGA-----LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQ 335
P+ GA + G L + +++ +D+G Y CTA N VG A++ V+L + + T
Sbjct: 4077 PVS-GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR-ARRRVHLTILVLPVFT-- 4132
Query: 336 ITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPA 395
+ +++LG L L C P ++ W N +P VT E
Sbjct: 4133 ----TLPGDRSLRLGDRLWLRCAARGSPTPRIG--WTVNDRP--------VTEGVSEQDG 4178
Query: 396 VTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVRE 455
S+L+ + D GTY+C A +S + + P V +G A + E
Sbjct: 4179 -GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF---VHVKEAP----VLQGEAFSYLVE 4230
Query: 456 --GSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLE------ETPDGKLRLERVSRD 507
G +L C VRG P P + W + GLPL + +G L + R RD
Sbjct: 4231 PVGGSIQLDCVVRGDPVPDIHW---------IKDGLPLRGSHLRHQLQNGSLTIHRTERD 4281
Query: 508 MSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSP 567
+G Y+C G + V L +Q P + QD+ G V LRC G P
Sbjct: 4282 DAGRYQCLAENEMGV----AKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT-GEP 4336
Query: 568 QRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSA 624
+ W GQ P PD L L+ V +G+Y+C N +GSA
Sbjct: 4337 T--PTIEWLQAGQ---PLRASRRLRTLPD-GSLWLENVETGDAGTYDCVAHNLLGSA 4387
Score = 109 bits (273), Expect = 1e-23
Identities = 150/637 (23%), Positives = 232/637 (36%), Gaps = 125/637 (19%)
Query: 13 PFHCRGQGVYAPAQAQ--IVHAGQACVVKEDNISERVYTIR--EGDTLMLQCLV-TGHPR 67
P+ C + V+ QA+ ++ G A I+ T+R EG + L C+V G P
Sbjct: 859 PYVCEARNVFGKVQAEARLIVTGHA----PPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 914
Query: 68 PQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQ 127
P+ W K + + + +L ++R + GRY C A N G S DV+
Sbjct: 915 PERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG-----SQHRDVE 969
Query: 128 YLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIY 187
+ + +H T + N + L C + P W + ++ L+
Sbjct: 970 LVVQVPPRIHPTATHHITN--EGVPASLPCVASGVPAPTITWTKETNALTSRG------- 1020
Query: 188 EPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVN 247
P Y + L + QD +Y C + N G + ++LSVN
Sbjct: 1021 -PHYNVSKEGTLLIAQPSAQDAGAYVCTAT--NTVGFSSQE-------------MRLSVN 1064
Query: 248 ETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYN 307
L + W G LP G+L + VQ DSG+Y
Sbjct: 1065 RLA-------------------LSKYVWEEY-GLLP------SGSLRLAQVQVGDSGHYE 1098
Query: 308 CTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKV 367
CTA+N G+ + + V + Q P V+K + +G+ L L+C + P+ ++
Sbjct: 1099 CTASNPAGSASHRYV---LGVQVPPQVQPGPRVLK----VLVGEALDLNCVAEGNPEPQL 1151
Query: 368 TYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDL 427
+ W K+G +++ P+ S+ + SD G Y C AS A V
Sbjct: 1152 S--WSKDG--------VVLQGRGPQ-----GSVHFAAIRTSDAGRYRCEAS-NSAGVDAW 1195
Query: 428 SVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPS 487
VE+ + PP + ++ G A L C RG P+P V W + PS
Sbjct: 1196 EVELRVLE---PPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKG-------PS 1245
Query: 488 GLPLEETP------DGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV 541
PL P +G L L VS SG Y CQ G R + +L V PP +
Sbjct: 1246 SEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSR----RAKLVVYVPPSI 1301
Query: 542 EPSSQ--DVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPP------------PV 587
+ +V G+ + L C G P + VW QL+ P
Sbjct: 1302 REDGRKANVSGMAGQSLTLECD-ANGFP--VPEIVWLKDAQLVGVPLGWAGYGWDLGWGQ 1358
Query: 588 VPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSA 624
V + L + SG Y C N G+A
Sbjct: 1359 VGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTA 1395
Score = 107 bits (268), Expect = 4e-23
Identities = 140/560 (25%), Positives = 210/560 (37%), Gaps = 85/560 (15%)
Query: 93 LRIERIARTQGGRYYCKAENGVGVPAIK-SIRVDVQYLDEPMLTVHQTVSDVRGNFYQEK 151
L+IE++ G Y C A N G + +++V V EP V +
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP--------GPVNKAVLENA 1901
Query: 152 TVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYAS 211
+V L C + PP W +G +S V + + +VL+++ + D S
Sbjct: 1902 SVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSV--------DGRVLRIEQAQLSDAGS 1953
Query: 212 YTCQVSVRNVCGIPDKAITFRLT---NTTAPPALKLSVNETLVVNPGENVTVQCLLTGGD 268
Y C S NV G + R+ T PP+L V LV P V + C TG
Sbjct: 1954 YRCVAS--NVAGSTELRYGLRVNVPPRITLPPSLPGPV---LVNTP---VRLTCNATGA- 2004
Query: 269 PLPQLQWSHGPGPLP------LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTV 322
P P L W P+ L G L++ S +A DSG Y+C A + VG + V
Sbjct: 2005 PSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 2064
Query: 323 NLLVRSMKNATFQITPDVIKESENIQL--GQDLKLSCHVDAVPQEKVTYQWFKNGKPARM 380
+ P ++ E N+ + + + L C A+P ++ W+K+G+P
Sbjct: 2065 ---------LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS--WWKDGRP--- 2110
Query: 381 SKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPP 440
L R L A + L++ D G Y C A A + +N+ V P
Sbjct: 2111 ----LEPRPGVHLSADKALLQVDRADVWDAGHYTCEA-LNQAGHSEKHYNLNVWVAPVFP 2165
Query: 441 TISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLR 500
+ +TVREG P L CE RG P P + W + + +GL L
Sbjct: 2166 L----RESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLY 2221
Query: 501 LERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV----EPSSQDVRQALGRPV 556
L + GTY C+ + G + +QL V PP++ EP +Q V
Sbjct: 2222 LGQAQLAQEGTYTCECSNVVGNS----SQDLQLEVHVPPQIAGPREPPTQ-VSVVQDGVA 2276
Query: 557 LLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAE-----APDHAELRLDAVTRDSSG 611
L C+ P + W GQ P AE L ++ +G
Sbjct: 2277 TLECNATGKPPPTV---TWERDGQ--------PVGAELGLQLQNQGQSLHVERAQAAHTG 2325
Query: 612 SYECSVSNDVGSAACLFQVS 631
Y C N G A F++S
Sbjct: 2326 RYSCVAENLAGRAERKFELS 2345
Score = 104 bits (259), Expect = 4e-22
Identities = 158/611 (25%), Positives = 225/611 (36%), Gaps = 90/611 (14%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTA----------------GSASDKFQETSVFNETLRIE 96
G +L L+C G P P++ W K A G ++L
Sbjct: 1315 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFP 1374
Query: 97 RIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLR 156
RI G Y C+AEN G A + + V L P + +V G V L+
Sbjct: 1375 RIQEGDSGLYSCRAENQAGT-AQRDFHLLV--LTPPSVLGAGAAQEVLG--LAGADVELQ 1429
Query: 157 CTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQV 216
C + P + W + + + L Q + +VL++ D Y C
Sbjct: 1430 CWTSGVPTPQVEWTKDRQPVLPGGPH-------LQVQEDGQVLRITGSHVGDEGRYQCVA 1482
Query: 217 SVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTG-GDPLPQLQW 275
+A F+L APP + S NET V E+ VQ L G P P + W
Sbjct: 1483 ----FSPAGQQARDFQL-RVHAPPTIWGS-NETGEVAVMEDHLVQLLCEARGVPTPNITW 1536
Query: 276 SHGPGPLPLGA---LAQGGT-LSIPSVQARDSGYYNCTATNNVGNPAKKT-VNLLVR-SM 329
LP +GG L + Q+ D+G Y C A+N VG K T +++ V ++
Sbjct: 1537 FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTI 1596
Query: 330 KNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRN 389
+ A + P V+K G+ + L C P T W G P S N
Sbjct: 1597 EGAGGR--PYVVKAVA----GRPVALECVARGHPSP--TLSWHHEGLPVAES-------N 1641
Query: 390 DPELPAVTSSLELIDLHFSDYGTYLCMASFP-GAPVPDLSVEVNISSETVPPTISVPKGR 448
+ L S L L + G Y C+AS P G V SVEV VPP + V +G
Sbjct: 1642 ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQ-----VPPQLLVAEGL 1696
Query: 449 AVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEE-------TPDGKLRL 501
VT G P EL C+ G P P + W L +G P EE + L +
Sbjct: 1697 GQVTTIVGQPLELPCQASGSPVPTIQW---------LQNGRPAEELAGVQVASQGTTLHI 1747
Query: 502 ERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV--EPSSQ---DVRQALGRPV 556
+ V D SG + CQ N E +V ++ ++ P V P Q P
Sbjct: 1748 DHVELDHSGLFACQAT--NEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPA 1805
Query: 557 LLRCSLLRG---SPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSY 613
+ RG P+ W G L P +P A P L+++ V G Y
Sbjct: 1806 ACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP--PPLQIEKVDLRDEGIY 1863
Query: 614 ECSVSNDVGSA 624
C+ +N G +
Sbjct: 1864 TCAATNLAGES 1874
Score = 98.6 bits (244), Expect = 2e-20
Identities = 140/618 (22%), Positives = 232/618 (37%), Gaps = 74/618 (11%)
Query: 30 VHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDK-FQETSV 88
VH + + +E N+S + +++ L+C P P + W K + S
Sbjct: 2067 VHMPPSILGEELNVS-----VVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSA 2121
Query: 89 FNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFY 148
L+++R G Y C+A N G + K ++V L T++ G+
Sbjct: 2122 DKALLQVDRADVWDAGHYTCEALNQAG-HSEKHYNLNVWVAPVFPLRESHTLTVREGH-- 2178
Query: 149 QEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQD 208
L C P + W++ L + G+ + ++L L +
Sbjct: 2179 ---PTSLSCECRGVPFPKISWRKDGQPLP-GEGAGLQ-----HVSAVGRLLYLGQAQLAQ 2229
Query: 209 YASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGD 268
+YTC+ S NV G + + + + + VV G T++C TG
Sbjct: 2230 EGTYTCECS--NVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV-ATLECNATGKP 2286
Query: 269 PLPQLQWSHGPGP----LPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNL 324
P P + W P L L QG +L + QA +G Y+C A N G +K
Sbjct: 2287 P-PTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKF--- 2342
Query: 325 LVRSMKNATFQITPDVIKESENIQ-----LGQDLKLSCHVDAVPQEKVTYQWFKNGKPAR 379
+ + P++I + + + L L L C +P + +WF+ +P
Sbjct: 2343 ------ELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAI--RWFRGEEPVS 2394
Query: 380 MSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP-GAPVPDLSVEVNISSETV 438
+ D L A L++ D G Y C+AS G + SVEV V
Sbjct: 2395 PGE-------DTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV-----LV 2442
Query: 439 PPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDG- 497
PP+I V+ V +G A L C V G P+P + W K+ L G +PDG
Sbjct: 2443 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWF---KDGRPLARGDAHHISPDGV 2499
Query: 498 KLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV-----EPSSQDVRQAL 552
L++ + + +G Y C A G + QL+V P + + + ++V +
Sbjct: 2500 LLQVLQANLSSAGHYSCIAANAVG----EKTKHFQLSVLLAPTILGGAEDSADEEVTVTV 2555
Query: 553 GRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGS 612
P+ L C L I W G P P L++ ++ +G
Sbjct: 2556 NNPISLICEALAFPSPNI---TWMKDG---APFEASRNIQLLPGTHGLQILNAQKEDAGQ 2609
Query: 613 YECSVSNDVGSAACLFQV 630
Y C V+N++G A + V
Sbjct: 2610 YTCVVTNELGEAVKNYHV 2627
Score = 93.2 bits (230), Expect = 1e-18
Identities = 137/586 (23%), Positives = 215/586 (36%), Gaps = 88/586 (15%)
Query: 57 MLQCLVTGHPRPQVRWTKTAGSASDKFQETS---VFNETLRIERIARTQGGRYYCKAENG 113
+L C +G P+P V W K + Q+ + + + L + ++ C N
Sbjct: 3782 LLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNE 3841
Query: 114 VGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFY--QEKTVFLRCTVNSNPPARFIWKR 171
VG + L + + V T++D + +F V L C P W +
Sbjct: 3842 VG---------EAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSK 3892
Query: 172 GSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAI-- 229
L ++ +G Y + L++ P YTC S RN G+ K +
Sbjct: 3893 AGAQLG-ARGSG-------YRVSPSGALEIGQALPIHAGRYTC--SARNSAGVAHKHVFL 3942
Query: 230 TFRLTNTTAP-PALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALA 288
T + + P P++ +V E V+ P E G P P + W + G
Sbjct: 3943 TVQASPVVKPLPSVVRAVAEEEVLLPCE--------ASGIPRPTITWQKEGLNVATGVST 3994
Query: 289 Q---GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESE 345
Q GG L I D+G Y C A N+ G+ KT Q+ P +
Sbjct: 3995 QVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKT---------RLVVQVPPVIENGLP 4045
Query: 346 NIQL--GQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELI 403
++ G L C P+ +T W K+G+P ++ + EL
Sbjct: 4046 DLSTTEGSHAFLPCKARGSPEPNIT--WDKDGQPVSGAEGKFTIQPSGELLVK------- 4096
Query: 404 DLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQC 463
+L D GTY C A V V+++ +P ++P R++ R G L+C
Sbjct: 4097 NLEGQDAGTYTCTAE---NAVGRARRRVHLTILVLPVFTTLPGDRSL---RLGDRLWLRC 4150
Query: 464 EVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFN 523
RG P P + W+ D+ S E+ L+ VSR+ SGTY C G
Sbjct: 4151 AARGSPTPRIGWTVNDRPVTEGVS----EQDGGSTLQRAAVSREDSGTYVCWAENRVGRT 4206
Query: 524 -----VRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFK 578
V +EA V F VEP +G + L C ++RG P + W
Sbjct: 4207 QAVSFVHVKEAPVLQGEAFSYLVEP--------VGGSIQLDC-VVRGDP--VPDIHWIKD 4255
Query: 579 GQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSA 624
G L + + L + RD +G Y+C N++G A
Sbjct: 4256 GLPLRGSHL----RHQLQNGSLTIHRTERDDAGRYQCLAENEMGVA 4297
Score = 92.0 bits (227), Expect = 2e-18
Identities = 146/628 (23%), Positives = 223/628 (35%), Gaps = 86/628 (13%)
Query: 40 EDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGS-ASDKFQETSVFNETLRIERI 98
E+ E V + +G T L C VTGHP+P++ W K A S L++ +
Sbjct: 2447 ENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQA 2506
Query: 99 ARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCT 158
+ G Y C A N VG K ++ V L +L + +D + L C
Sbjct: 2507 NLSSAGHYSCIAANAVG-EKTKHFQLSV-LLAPTILGGAEDSADEEVTVTVNNPISLICE 2564
Query: 159 VNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSV 218
+ P W + S++ + T L++ N + +D YTC V+
Sbjct: 2565 ALAFPSPNITWMKDGAPFEASRN--------IQLLPGTHGLQILNAQKEDAGQYTCVVT- 2615
Query: 219 RNVCGIPDKAITFRLTNTTAPPAL-------KLSVNETLVVNPGENVTVQCLLTGGDPLP 271
N G +A+ PP++ ++ V E + +T++C + P P
Sbjct: 2616 -NELG---EAVKNYHVEVLIPPSISKDDPLGEVGVKE-VKTKVNSTLTLEC-ESWAVPPP 2669
Query: 272 QLQWSHGPGPLP----LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVR 327
++W P+ L L +G L I Q DSG Y C ATN G + N+L++
Sbjct: 2670 TIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGED-DQDFNVLIQ 2728
Query: 328 ----SMKNATFQITPDVIKESENIQLG----------QDLKLSCHVDAVPQEKVTYQWFK 373
K F +++ E + G L C +A+P +T W++
Sbjct: 2729 VPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLT--WYR 2786
Query: 374 NGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNI 433
+P + V + L++ + + G Y C AS L E+ +
Sbjct: 2787 EDQPLSAGDEVSVLQGG-------RVLQIPLVRAENAGRYSCKAS-NEVGEDWLHYELLV 2838
Query: 434 SSETVPPTISVPKGRAV--VTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPL 491
PP I V VTV S LQC G P P + W L +GLP
Sbjct: 2839 ---LTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW---------LQNGLPF 2886
Query: 492 EETP------DGK-LRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEP- 543
+P DG+ L++ + +Y C G E L VQ PP +
Sbjct: 2887 SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG----SAEKLFTLRVQVPPRIAGL 2942
Query: 544 SSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLD 603
+ V L V L C + P W Q L + P L+L
Sbjct: 2943 DLEQVTAILNSSVSLPCD-VHAHPN--PEVTWYKDSQAL---SLGEEVFLLPGTHTLQLG 2996
Query: 604 AVTRDSSGSYECSVSNDVGSAACLFQVS 631
SG Y C N G L Q+S
Sbjct: 2997 RARLSDSGMYTCEALNAAGRDQKLVQLS 3024
Score = 72.8 bits (177), Expect = 1e-12
Identities = 72/285 (25%), Positives = 115/285 (40%), Gaps = 33/285 (11%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYC 108
++R GD L L+C G P P++ WT ++ E TL+ ++R G Y C
Sbjct: 4139 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDG-GSTLQRAAVSREDSGTYVC 4197
Query: 109 KAENGVGVPAIKSIRVDVQYLDEPML---TVHQTVSDVRGNFYQEKTVFLRCTVNSNPPA 165
AEN VG S V + P+L V V G+ + L C V +P
Sbjct: 4198 WAENRVGRTQAVSF---VHVKEAPVLQGEAFSYLVEPVGGS------IQLDCVVRGDPVP 4248
Query: 166 RFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIP 225
W + L S L Q + L + D Y C N G+
Sbjct: 4249 DIHWIKDGLPLRGSH---------LRHQLQNGSLTIHRTERDDAGRYQCLAE--NEMGVA 4297
Query: 226 DKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG 285
K + L + P ++ + + V G++V ++C TG +P P ++W PL
Sbjct: 4298 KKVVILVLQSA---PVFQVEPQD-MTVRSGDDVALRCQATG-EPTPTIEWLQAGQPLRAS 4352
Query: 286 ALAQ---GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVR 327
+ G+L + +V+ D+G Y+C A N +G+ + L+VR
Sbjct: 4353 RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAF-LVVR 4396
Score = 55.1 bits (131), Expect = 3e-07
Identities = 44/151 (29%), Positives = 62/151 (41%), Gaps = 9/151 (5%)
Query: 30 VHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF 89
VH +A V++ + S V + G ++ L C+V G P P + W K +
Sbjct: 4212 VHVKEAPVLQGEAFSYLVEPV--GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQ 4269
Query: 90 NETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQ 149
N +L I R R GRY C AEN +GV A K + + +Q P+ V VR
Sbjct: 4270 NGSLTIHRTERDDAGRYQCLAENEMGV-AKKVVILVLQ--SAPVFQVEPQDMTVRSG--- 4323
Query: 150 EKTVFLRCTVNSNPPARFIWKRGSDTLSHSQ 180
V LRC P W + L S+
Sbjct: 4324 -DDVALRCQATGEPTPTIEWLQAGQPLRASR 4353
Score = 41.6 bits (96), Expect = 0.004
Identities = 24/111 (21%), Positives = 48/111 (43%), Gaps = 2/111 (1%)
Query: 14 FHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWT 73
+ C + A+ ++ Q+ V + + + T+R GD + L+C TG P P + W
Sbjct: 4286 YQCLAENEMGVAKKVVILVLQSAPVFQ--VEPQDMTVRSGDDVALRCQATGEPTPTIEWL 4343
Query: 74 KTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRV 124
+ + ++ + +L +E + G Y C A N +G ++ V
Sbjct: 4344 QAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLV 4394
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 142 bits (359), Expect = 1e-33
Identities = 156/608 (25%), Positives = 236/608 (38%), Gaps = 81/608 (13%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCK 109
+ +G + L+C V+G P W++ G + L + + G Y C
Sbjct: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICT 1747
Query: 110 AENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKT-VFLRCTVNSNPPA-RF 167
N + + R ++ + P + TV + R + V CT S PA
Sbjct: 1748 CRN---LHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTL 1804
Query: 168 IWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDK 227
+W R NG P +L ++N++ D +Y C S
Sbjct: 1805 VWTR--------LHNGK---LPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTA 1853
Query: 228 AITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPG-PLPLGA 286
+ + + T + P + + + L V PG+ +C TG P P L+W+ GPG LP A
Sbjct: 1854 TLHVQASGTLSAPVVSIHPPQ-LTVQPGQLAEFRCSATGS-PTPTLEWTGGPGGQLPAKA 1911
Query: 287 LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESEN 346
GG L +P+V+ D Y C A ++ G + V L V Q++P E
Sbjct: 1912 QIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAV-LHVHGGGGPRVQVSP----ERTQ 1966
Query: 347 IQLGQDLKLSCHVDAVPQEKVTYQWFKNG---KPARMSKRLLVTRNDPELPAVTSSLELI 403
+ G+ ++L C VP +T W K G P S+R + +PA+T+
Sbjct: 1967 VHAGRTVRLYCRAAGVPSATIT--WRKEGGSLPPQARSERTDIA--TLLIPAITT----- 2017
Query: 404 DLHFSDYGTYLCMASFP-GAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQ 462
+D G YLC+A+ P G + V V +S+ PP + + VT EG +L
Sbjct: 2018 ----ADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVT--EGQTLDLN 2071
Query: 463 CEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGF 522
C V G V W R LP P + +LRL +VS SG Y C+ +G
Sbjct: 2072 CVVAGSAHAQVTWYR---RGGSLP---PHTQVHGSRLRLPQVSPADSGEYVCRVENGSG- 2124
Query: 523 NVRPREAQVQLNVQF----------------PPEVEPSSQDVRQALGRPVLLRCSLLRGS 566
P+EA + ++V P +EPSS V A G+ + L C +
Sbjct: 2125 ---PKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHV--AEGQTLDLNCVV---P 2176
Query: 567 PQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAAC 626
Q A W +G LP A + LRL VT SG Y C V G
Sbjct: 2177 GQAHAQVTWHKRGGSLP-------ARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEA 2229
Query: 627 LFQVSAKA 634
V+ +A
Sbjct: 2230 SVLVTIEA 2237
Score = 133 bits (335), Expect = 7e-31
Identities = 171/693 (24%), Positives = 260/693 (37%), Gaps = 108/693 (15%)
Query: 14 FHCRGQGVYAPAQAQI---VHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQV 70
+ C Y AQ+ + VH V + E ++ G + L+C+ G PR
Sbjct: 3089 YRCVASNAYGVAQSVVNLSVHGPPTVSV----LPEGPVWVKVGKAVTLECVSAGEPRSSA 3144
Query: 71 RWTKTAGSASDKFQETSVFNET---LRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQ 127
RWT+ + + + Q T ++ L+I + G Y C A+N +G A K + V V
Sbjct: 3145 RWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGT-AQKQVEVIVD 3203
Query: 128 Y----LDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNG 183
P + + V T LRC+ +P W + L
Sbjct: 3204 TGAMAPGAPQVQAEEAELTVEAGH----TATLRCSATGSPAPTIHWSKLRSPL------- 3252
Query: 184 VDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALK 243
P + E L + + QD Y C + + G + I + + P
Sbjct: 3253 -----PWQHRLEGDTLIIPRVAQQDSGQYICNAT--SPAGHAEATIILHVES----PPYA 3301
Query: 244 LSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDS 303
+V E V GE V +QCL G PL QWS LP A A+ L DS
Sbjct: 3302 TTVPEHASVQAGETVQLQCLAHGTPPLT-FQWSRVGSSLPGRATARNELLHFERAAPEDS 3360
Query: 304 GYYNCTATNNVGNPAKKTVNLLVRSMKNA------------TFQITPDVIKESENIQLGQ 351
G Y C TN VG+ A+ LLV+ + T Q+TP + E +G
Sbjct: 3361 GRYRCRVTNKVGS-AEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQL----ETKSIGA 3415
Query: 352 DLKLSCHVDAVPQEKVTY-QWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDY 410
++ C AVP ++ T +WFK G P L + +L S
Sbjct: 3416 SVEFHC---AVPSDRGTQLRWFKEGGQL-----------PPGHSVQDGVLRIQNLDQSCQ 3461
Query: 411 GTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPR 470
GTY+C A P S ++ I + P++ + +V TV G E +C G P+
Sbjct: 3462 GTYICQAHGPWGKA-QASAQLVIQAL---PSVLINIRTSVQTVVVGHAVEFECLALGDPK 3517
Query: 471 PPVLWSRVDKEA--ALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPRE 528
P V WS+V ++ SG G +R+ V +G YRC G +
Sbjct: 3518 PQVTWSKVGGHLRPGIVQSG--------GVVRIAHVELADAGQYRCTATNAAGTT----Q 3565
Query: 529 AQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVV 588
+ V L VQ P++ Q+VR G + C + G P S W LPP +
Sbjct: 3566 SHVLLLVQALPQIS-MPQEVRVPAGSAAVFPC-IASGYPTPDIS--WSKLDGSLPPDSRL 3621
Query: 589 PAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPN--- 645
++ L L +V +G+Y C+ +N G + ++ TP
Sbjct: 3622 -------ENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSFL 3674
Query: 646 --PTRSHKLSKNYSYVLQWTQREPDAVDPVLNY 676
PT K + ++ T R PD+ D +L Y
Sbjct: 3675 PLPTIKDAYRK---FEIKITFR-PDSADGMLLY 3703
Score = 131 bits (330), Expect = 3e-30
Identities = 161/621 (25%), Positives = 240/621 (38%), Gaps = 90/621 (14%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCK 109
+ EG TL L C+V G QV W K GS + Q LR+ + + G Y C+
Sbjct: 2352 VAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQ---THGSLLRLYQASPADSGEYVCR 2408
Query: 110 AENGVGVPAIKSIRVDVQYLDE-PMLTVHQTV--SDVRGNFYQEKTVFLRCTVNSNPPAR 166
G VP S+ V ++ P L V TV + +T+ L C V A+
Sbjct: 2409 VL-GSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQ 2467
Query: 167 FIW-KRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIP 225
W KRG + Q +G L+L + P D Y C+V +
Sbjct: 2468 VTWHKRGGSLPARHQVHG-------------SRLRLLQVTPADSGEYVCRVVGSSGTQEA 2514
Query: 226 DKAITF--RLTNTTAPPA---LKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPG 280
+T RL+ + + +++ + + N G + + CL+ P + W G
Sbjct: 2515 SVLVTIQQRLSGSHSQGVAYPVRIESSSASLAN-GHTLDLNCLVASQAP-HTITWYKRGG 2572
Query: 281 PLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDV 340
LP G L IP V DSG Y C +N G+ + + S + ++P +
Sbjct: 2573 SLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPI 2632
Query: 341 IKESEN--IQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTS 398
ES + + GQ L L+C V PQ +T W+K G L +R+ S
Sbjct: 2633 RIESSSPTVVEGQTLDLNCVVARQPQAIIT--WYKRGGS-------LPSRHQTH----GS 2679
Query: 399 SLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVT------ 452
L L + +D G Y+C A+ + S+ +++S P S P +
Sbjct: 2680 HLRLHQMSVADSGEYVCRAN-NNIDALEASIVISVSPSAGSP--SAPGSSMPIRIESSSS 2736
Query: 453 -VREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGT 511
V EG +L C V G+ V W K LPS +T +LRL VS SG
Sbjct: 2737 HVAEGETLDLNCVVPGQAHAQVTW---HKRGGSLPSH---HQTRGSRLRLHHVSPADSGE 2790
Query: 512 YRCQTARYNGFNVRPREAQVQLNVQF---------------PPEVEPSSQDVRQALGRPV 556
Y C+ +G P EA V + ++ P +EPSS R A G+ +
Sbjct: 2791 YVCRVMGSSG----PLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSS--RVAEGQTL 2844
Query: 557 LLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECS 616
L+C + Q A W +G LP A LRL+ V+ SG Y C
Sbjct: 2845 DLKCVV---PGQAHAQVTWHKRGGNLP-------ARHQVHGPLLRLNQVSPADSGEYSCQ 2894
Query: 617 VSNDVGSAACLFQVSAKAYSP 637
V+ G+ V+ + SP
Sbjct: 2895 VTGSSGTLEASVLVTIEPSSP 2915
Score = 127 bits (319), Expect = 5e-29
Identities = 150/616 (24%), Positives = 234/616 (37%), Gaps = 97/616 (15%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCK 109
+ EG TL L C+V G QV W K GS + Q LR+ ++ G Y C+
Sbjct: 2936 VTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQ---THGSQLRLHLVSPADSGEYVCR 2992
Query: 110 AENGVGVPAIKSIRVDV-------QYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSN 162
A +G G S V V L P++++ S V+ Q + +C ++
Sbjct: 2993 AASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQ----QGQDASFKCLIHDG 3048
Query: 163 -PPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNV 221
P WK + L +DN ++ ++ + RP ++ +Y C S N
Sbjct: 3049 AAPISLEWKTRNQEL---EDN-------VHISPNGSIITIVGTRPSNHGTYRCVAS--NA 3096
Query: 222 CGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQW---SHG 278
G+ + + PP + + + V G+ VT++C ++ G+P +W S
Sbjct: 3097 YGVAQSVVNL---SVHGPPTVSVLPEGPVWVKVGKAVTLEC-VSAGEPRSSARWTRISST 3152
Query: 279 PGPL---PLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQ 335
P L G + L I S + D+G Y C A N +G A+K V ++V + A
Sbjct: 3153 PAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGT-AQKQVEVIVDTGAMAPGA 3211
Query: 336 ITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPA 395
+ ++ G L C P T W K P RL + +P
Sbjct: 3212 PQVQAEEAELTVEAGHTATLRCSATGSPAP--TIHWSKLRSPLPWQHRL--EGDTLIIPR 3267
Query: 396 VTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVRE 455
V D G Y+C A+ +P + + E+ P +VP+ +V+
Sbjct: 3268 VAQ---------QDSGQYICNAT---SPAGHAEATIILHVESPPYATTVPEH---ASVQA 3312
Query: 456 GSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGK-LRLERVSRDMSGTYRC 514
G +LQC G P WSRV S LP T + L ER + + SG YRC
Sbjct: 3313 GETVQLQCLAHGTPPLTFQWSRVG-------SSLPGRATARNELLHFERAAPEDSGRYRC 3365
Query: 515 QTARYNGFNVRPREAQVQLNVQFP--------------PEVEPSSQDVRQALGRPVLLRC 560
+ V EA QL VQ P P V+ + Q +++G V C
Sbjct: 3366 RVTN----KVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHC 3421
Query: 561 SLL--RGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVS 618
++ RG+ R W +G LPP + LR+ + + G+Y C
Sbjct: 3422 AVPSDRGTQLR-----WFKEGGQLPP-------GHSVQDGVLRIQNLDQSCQGTYICQAH 3469
Query: 619 NDVGSAACLFQVSAKA 634
G A Q+ +A
Sbjct: 3470 GPWGKAQASAQLVIQA 3485
Score = 122 bits (307), Expect = 1e-27
Identities = 161/655 (24%), Positives = 245/655 (37%), Gaps = 90/655 (13%)
Query: 16 CRGQGVYAPAQAQIVHAGQACVVKED----NISERVYTIREGDTLMLQCLVTGHPRPQVR 71
C G P +A ++ +A V+ I T+ EG TL L C+V G QV
Sbjct: 2218 CHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVT 2277
Query: 72 WTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDE 131
W K GS + Q V L I + + G+Y C+A NG+ SI V V
Sbjct: 2278 WYKRGGSLPARHQ---VRGSRLYIFQASPADAGQYVCRASNGMEA----SITVTVTGTQG 2330
Query: 132 PML------TVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVD 185
L T + + +T+ L C V A+ W + +L
Sbjct: 2331 ANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL--------- 2381
Query: 186 IYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTT----APPA 241
P+ Q +L+L P D Y C+V +V +T + P
Sbjct: 2382 ---PVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPT 2438
Query: 242 LKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQAR 301
+++ + + V G+ + + CL+ G Q+ W G LP G L + V
Sbjct: 2439 VRIESSSSQVAE-GQTLDLNCLV-AGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPA 2496
Query: 302 DSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQ-ITPDVIKESENIQL--GQDLKLSCH 358
DSG Y C + G + + + + + Q + V ES + L G L L+C
Sbjct: 2497 DSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCL 2556
Query: 359 VDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLC-MA 417
V Q T W+K G + R + + +P VT +D G Y+C ++
Sbjct: 2557 V--ASQAPHTITWYKRG--GSLPSRHQIVGSRLRIPQVTP---------ADSGEYVCHVS 2603
Query: 418 SFPGAPVPDLSVEVNISSETVPPTISVP--KGRAVVTVREGSPAELQCEVRGKPRPPVLW 475
+ G+ L V + S + P++S P + TV EG +L C V +P+ + W
Sbjct: 2604 NGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITW 2663
Query: 476 SRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNV 535
K LPS +T LRL ++S SG Y C+ N+ EA + ++V
Sbjct: 2664 Y---KRGGSLPS---RHQTHGSHLRLHQMSVADSGEYVCRANN----NIDALEASIVISV 2713
Query: 536 ------------QFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLP 583
P +E SS V A G + L C + Q A W +G LP
Sbjct: 2714 SPSAGSPSAPGSSMPIRIESSSSHV--AEGETLDLNCVV---PGQAHAQVTWHKRGGSLP 2768
Query: 584 PPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVG--SAACLFQVSAKAYS 636
+ + LRL V+ SG Y C V G A+ L + A S
Sbjct: 2769 -------SHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSS 2816
Score = 122 bits (305), Expect = 2e-27
Identities = 153/594 (25%), Positives = 227/594 (38%), Gaps = 81/594 (13%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYC 108
T+++G +CL+ P KT + S + I + G Y C
Sbjct: 3032 TVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRC 3091
Query: 109 KAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQE--KTVFLRCTVNSNPPAR 166
A N GV +S+ V++ P ++V G + + K V L C P +
Sbjct: 3092 VASNAYGVA--QSV-VNLSVHGPPTVSVLP-----EGPVWVKVGKAVTLECVSAGEPRSS 3143
Query: 167 FIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPD 226
W R S T + + + + VL++ + +P D +Y C +N G
Sbjct: 3144 ARWTRISSTPAKLEQRTYGLMD------SHAVLQISSAKPSDAGTYVCLA--QNALGTAQ 3195
Query: 227 KAITFRL-TNTTAPPALKLSVNET-LVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPL 284
K + + T AP A ++ E L V G T++C TG P P + WS PLP
Sbjct: 3196 KQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGS-PAPTIHWSKLRSPLPW 3254
Query: 285 GALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKES 344
+G TL IP V +DSG Y C AT+ G+ A+ T+ L V S AT + E
Sbjct: 3255 QHRLEGDTLIIPRVAQQDSGQYICNATSPAGH-AEATIILHVESPPYAT------TVPEH 3307
Query: 345 ENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGK--PARMSKRLLVTRNDPELPAVTSSLEL 402
++Q G+ ++L C P +T+QW + G P R + R + + P
Sbjct: 3308 ASVQAGETVQLQCLAHGTP--PLTFQWSRVGSSLPGRATARNELLHFERAAP-------- 3357
Query: 403 IDLHFSDYGTYLC-MASFPGAPVPDLSVEVNISSETVPPTISVPKGRA--------VVTV 453
D G Y C + + G+ + V ++P T S+P G + T
Sbjct: 3358 -----EDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPAT-SIPAGSTPTVQVTPQLETK 3411
Query: 454 REGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYR 513
G+ E C V + W KE LP G DG LR++ + + GTY
Sbjct: 3412 SIGASVEFHCAVPSDRGTQLRWF---KEGGQLPPG---HSVQDGVLRIQNLDQSCQGTYI 3465
Query: 514 CQTARYNGFNVRPREAQVQLNVQFPPEV----EPSSQDVRQALGRPVLLRCSLLRGSPQR 569
CQ G +A QL +Q P V S Q V +G V C L G P+
Sbjct: 3466 CQAHGPWG----KAQASAQLVIQALPSVLINIRTSVQTV--VVGHAVEFEC-LALGDPK- 3517
Query: 570 IASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGS 623
W G L P V H EL +G Y C+ +N G+
Sbjct: 3518 -PQVTWSKVGGHLRPGIVQSGGVVRIAHVELA-------DAGQYRCTATNAAGT 3563
Score = 115 bits (288), Expect = 2e-25
Identities = 145/603 (24%), Positives = 238/603 (39%), Gaps = 75/603 (12%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYC 108
T+ EG TL L C+V P+ + W K GS + Q LR+ +++ G Y C
Sbjct: 2640 TVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQ---THGSHLRLHQMSVADSGEYVC 2696
Query: 109 KAENGVGV---PAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPA 165
+A N + + S+ P ++ + + + +T+ L C V A
Sbjct: 2697 RANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHA 2756
Query: 166 RFIW-KRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGI 224
+ W KRG SH Q G L+L ++ P D Y C+V +
Sbjct: 2757 QVTWHKRGGSLPSHHQTRG-------------SRLRLHHVSPADSGEYVCRVMGSSGPLE 2803
Query: 225 PDKAITFRLTNTTA--------PPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWS 276
+T + ++A P +++ + + V G+ + ++C++ G Q+ W
Sbjct: 2804 ASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAE-GQTLDLKCVVPG-QAHAQVTWH 2861
Query: 277 HGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKN---AT 333
G LP G L + V DSG Y+C T + G + + S A
Sbjct: 2862 KRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAP 2921
Query: 334 FQITPDVIK-ESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNG--KPARMSKRLLVTRND 390
P I+ S ++ GQ L L+C V +VT W+K G PAR
Sbjct: 2922 GLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVT--WYKRGGSLPARHQTH------- 2972
Query: 391 PELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNI------SSETVPPTISV 444
S L L + +D G Y+C A+ P + S V + S P IS+
Sbjct: 2973 ------GSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISI 3026
Query: 445 PKGRAVVTVREGSPAELQCEVRGKPRPPVL-WSRVDKEAALLPSGLPLEETPDGKLRLER 503
+ TV++G A +C + P L W ++E L + + +P+G +
Sbjct: 3027 DPPSS--TVQQGQDASFKCLIHDGAAPISLEWKTRNQE---LEDNVHI--SPNGSIITIV 3079
Query: 504 VSRDMS-GTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQ-DVRQALGRPVLLRCS 561
+R + GTYRC + N + V ++ V L+V PP V + V +G+ V L C
Sbjct: 3080 GTRPSNHGTYRCVAS--NAYGV--AQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLEC- 3134
Query: 562 LLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDV 621
+ G P+ +SA W + P HA L++ + +G+Y C N +
Sbjct: 3135 VSAGEPR--SSARWT-RISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNAL 3191
Query: 622 GSA 624
G+A
Sbjct: 3192 GTA 3194
Score = 109 bits (273), Expect = 1e-23
Identities = 148/629 (23%), Positives = 223/629 (35%), Gaps = 86/629 (13%)
Query: 16 CRGQGVYAPAQAQI---VHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRW 72
C G ++A Q V A +I T++ G +C TG P P + W
Sbjct: 1840 CTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEW 1899
Query: 73 TKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEP 132
T G + + LR+ + T +Y C+A + G Q +
Sbjct: 1900 --TGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAG-----------QQVARA 1946
Query: 133 MLTVH------QTVSDVRGNFYQEKTVFLRCTVNSNPPARFIW-KRGSDTLSHSQDNGVD 185
+L VH VS R + +TV L C P A W K G ++ D
Sbjct: 1947 VLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTD 2006
Query: 186 IYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLS 245
I L + + D Y C + + + +PP +K+
Sbjct: 2007 I----------ATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIE 2056
Query: 246 VNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGY 305
+ + V G+ + + C++ G Q+ W G LP G L +P V DSG
Sbjct: 2057 -SSSPSVTEGQTLDLNCVV-AGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGE 2114
Query: 306 YNCTATNNVG-NPAKKTVNLLVRSMKNATFQITPD------VIKESENIQLGQDLKLSCH 358
Y C N G A TV++L + ++ P + S ++ GQ L L+C
Sbjct: 2115 YVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCV 2174
Query: 359 VDAVPQEKVTYQWFKNG--KPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCM 416
V +VT W K G PAR + R PA D G Y+C
Sbjct: 2175 VPGQAHAQVT--WHKRGGSLPARHQTHGSLLRLHQVTPA-------------DSGEYVCH 2219
Query: 417 ASFPGAPVPDLSVEVNISSETVP-PTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLW 475
P+ + SV V I + +P P V + TV EG +L C V G+ V W
Sbjct: 2220 VVGTSGPL-EASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTW 2278
Query: 476 SRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQ-LN 534
K LP+ + +L + + S +G Y C+ + ++ Q N
Sbjct: 2279 Y---KRGGSLPA---RHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGAN 2332
Query: 535 VQFPP------EVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVV 588
+ +P +EPSS V A G+ + L C + Q A W +G LP
Sbjct: 2333 LAYPAGSTQPIRIEPSSSQV--AEGQTLDLNCVV---PGQSHAQVTWHKRGGSLP----- 2382
Query: 589 PAAAEAPDHAELRLDAVTRDSSGSYECSV 617
+ LRL + SG Y C V
Sbjct: 2383 --VRHQTHGSLLRLYQASPADSGEYVCRV 2409
Score = 109 bits (272), Expect = 1e-23
Identities = 161/630 (25%), Positives = 233/630 (36%), Gaps = 104/630 (16%)
Query: 30 VHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF 89
VH G V+ +S + G T+ L C G P + W K GS + +
Sbjct: 1950 VHGGGGPRVQ---VSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTD 2006
Query: 90 NETLRIERIARTQGGRYYCKAEN--GVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNF 147
TL I I G Y C A + G I+ + + P + + + V
Sbjct: 2007 IATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVT--- 2063
Query: 148 YQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQ 207
+ +T+ L C V + A+ W R +L P +TQ L+L + P
Sbjct: 2064 -EGQTLDLNCVVAGSAHAQVTWYRRGGSL------------PPHTQVHGSRLRLPQVSPA 2110
Query: 208 DYASYTCQVSVRNVCGIPDKAITFRLTN-------------TTAPPALKLSVNETLVVNP 254
D Y C+ V N G + +IT + + +T P ++ S + V
Sbjct: 2111 DSGEYVCR--VENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSH---VAE 2165
Query: 255 GENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNV 314
G+ + + C++ G Q+ W G LP G L + V DSG Y C + V
Sbjct: 2166 GQTLDLNCVVP-GQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVC---HVV 2221
Query: 315 GNPAKKTVNLLVRSMKNATFQITPDVIKESEN--IQLGQDLKLSCHVDAVPQEKVTYQWF 372
G ++LV + P V ES + + GQ L LSC V +VT W+
Sbjct: 2222 GTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVT--WY 2279
Query: 373 KNG--KPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVE 430
K G PAR R S L + +D G Y+C AS + S+
Sbjct: 2280 KRGGSLPARHQVR-------------GSRLYIFQASPADAGQYVCRAS----NGMEASIT 2322
Query: 431 VNISSETVPPTISVPKGR--------AVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEA 482
V ++ T ++ P G + V EG +L C V G+ V W K
Sbjct: 2323 VTVTG-TQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTW---HKRG 2378
Query: 483 ALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQ------ 536
LP +T LRL + S SG Y C R G +V P EA V + ++
Sbjct: 2379 GSLP---VRHQTHGSLLRLYQASPADSGEYVC---RVLGSSV-PLEASVLVTIEPAGSVP 2431
Query: 537 ---FPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAE 593
P V S + A G+ + L C L+ G Q A W +G LP A
Sbjct: 2432 ALGVTPTVRIESSSSQVAEGQTLDLNC-LVAG--QAHAQVTWHKRGGSLP-------ARH 2481
Query: 594 APDHAELRLDAVTRDSSGSYECSVSNDVGS 623
+ LRL VT SG Y C V G+
Sbjct: 2482 QVHGSRLRLLQVTPADSGEYVCRVVGSSGT 2511
Score = 40.0 bits (92), Expect = 0.010
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 7/83 (8%)
Query: 239 PPALKLSVNETLVVNPGENVTVQCLLTGGDPLP----QLQWSHGPGPLPLGALAQGG--T 292
PP + E++ + G+ VT C+ G P P +L W H P + ++GG T
Sbjct: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGV-PTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
Query: 293 LSIPSVQARDSGYYNCTATNNVG 315
L I V+ D G Y C A N G
Sbjct: 464 LIIRDVKESDQGAYTCEAMNARG 486
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 139 bits (351), Expect = 1e-32
Identities = 166/602 (27%), Positives = 238/602 (39%), Gaps = 84/602 (13%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF--NETLRIERIARTQGGRYY 107
+R GD +L C P P V W K G Q T + L I+ + G Y
Sbjct: 1853 VRVGDKAVLSCETDALPEPTVTWYKD-GQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYS 1911
Query: 108 CKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARF 167
CK N G A+++ + VQ +TVS V G+ + L C V+ P
Sbjct: 1912 CKVSNVAG-EAVRTFTLTVQVPPTFENPKTETVSQVAGS-----PLVLTCDVSGVPAPTV 1965
Query: 168 IWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDK 227
W + + S +GV ++G L+L L+P +YTC D
Sbjct: 1966 TWLKDRMPVESSAVHGV------VSRGGR--LQLSRLQPAQAGTYTCVAENTQAEARKD- 2016
Query: 228 AITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPL----- 282
F + AP V V G+ V + C G P P + W PL
Sbjct: 2017 ---FVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC-EADGQPPPDVAWLKDGSPLGQDMG 2072
Query: 283 -PLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAK-KTVNLLVRSMKNATFQITPDV 340
L GG+L + ++A D+G Y C A N G A+ TVN+LV P
Sbjct: 2073 PHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV-----------PPT 2121
Query: 341 IKESEN------IQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELP 394
IK+ + + G+ + + C V P V+ W K+G P +S+R L L
Sbjct: 2122 IKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVS--WLKDGLPLPLSQRTL-------LH 2172
Query: 395 AVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVR 454
+L + + +D G + C+A+ P A V D + + + VPP + + + V V
Sbjct: 2173 GSGHTLRISKVQLADAGIFTCVAASP-AGVADRNFTLQVQ---VPPVLEPVEFQNDVVVV 2228
Query: 455 EGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRC 514
GS EL CE RG P P V W + D E L S LE+ P L+LE V SGTY C
Sbjct: 2229 RGSLVELPCEARGVPLPLVSWMK-DGEPLLSQS---LEQGP--SLQLEAVGAGDSGTYSC 2282
Query: 515 QTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQAL--GRPVLLRCSLLRGSPQRIAS 572
G QL V PP +E S Q +L G P+ L C +G+PQ +
Sbjct: 2283 VAVSEAG----EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCD-AQGTPQ--PN 2335
Query: 573 AVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSA 632
W GQ A +++ RD +G Y C + G+ F+V
Sbjct: 2336 ITWHKDGQ---------ALTRLENNSRATRVLRVRD-AGLYTCLAESPAGAIEKSFRVRV 2385
Query: 633 KA 634
+A
Sbjct: 2386 QA 2387
Score = 130 bits (328), Expect = 4e-30
Identities = 159/595 (26%), Positives = 236/595 (39%), Gaps = 67/595 (11%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQET-SVFNETLRIERIARTQGGRYYC 108
+ E ++ L+CL +G P P V W K S T SV LRIE+ + G Y C
Sbjct: 706 VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRC 765
Query: 109 KAENGVGVPAIK-SIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARF 167
A N G ++ +RV+V P +T+ ++ G V L C P
Sbjct: 766 VASNVAGSTELRYGLRVNV----PPRITLPPSLP---GPVLVNTPVRLTCNATGAPSPTL 818
Query: 168 IWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDK 227
+W + + +S + G+ ++ +VL L + R D Y+C V + +
Sbjct: 819 MWLKDGNPVSPAGTPGLQVFP------GGRVLTLASARASDSGRYSCVA----VSAVGED 868
Query: 228 AITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP---- 283
L P L +N ++V N E+V ++C + P P L W PL
Sbjct: 869 RQDVVLQVHMPPSILGEELNVSVVAN--ESVALEC-QSHAMPPPVLSWWKDGRPLEPRPG 925
Query: 284 LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKE 343
+ A L + D+G+Y C A N G ++K NL V + P
Sbjct: 926 VHLSADKALLQVDRADVWDAGHYTCEALNQAGR-SEKHYNLNV-----WVAPVFPLRESH 979
Query: 344 SENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELI 403
+ ++ G LSC VP K++ W K+G+P L + AV L L
Sbjct: 980 TLTVREGHPTSLSCECRGVPFPKIS--WRKDGQPLPGEGAGL-----QHVSAVGRLLYLG 1032
Query: 404 DLHFSDYGTYLCMAS-FPGAPVPDLSVEVNISSETVPPTISVPKGRAV-VTVREGSPAEL 461
+ GTY C S G DL +EV+ VPP I+ P+ V+V + A L
Sbjct: 1033 QAQLAQEGTYTCECSNVVGNSSQDLQLEVH-----VPPQIAGPREPPTQVSVVQDGVATL 1087
Query: 462 QCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNG 521
+C GKP P V W R D + GL L+ L +ER +G Y C G
Sbjct: 1088 ECNATGKPPPTVTWER-DGQPVGAELGLQLQNQGQ-SLHVERAQAAHTGRYSCVAENLAG 1145
Query: 522 FNVRPREAQVQLNVQFPPE----VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRF 577
E + +L+V PPE ++P + ++ AL P+ L C + P I W F
Sbjct: 1146 ----RAERKFELSVLVPPELIGDLDPLT-NITAALHSPLTLLCEAMGIPPPAIR---W-F 1196
Query: 578 KGQLLPPPPVVPAAAE--APDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQV 630
+G+ PV P L++ SG Y C SN+ G A F V
Sbjct: 1197 RGE----EPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSV 1247
Score = 125 bits (314), Expect = 2e-28
Identities = 164/596 (27%), Positives = 240/596 (40%), Gaps = 85/596 (14%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE-TLRIERIARTQGGRYYCKAE 111
G L+L C V+G P P V W K V L++ R+ Q G Y C AE
Sbjct: 1948 GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAE 2007
Query: 112 NGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKR 171
N A K V V L P + + + + + V L C + PP W +
Sbjct: 2008 N-TQAEARKDFVVAV--LVAPRIRSSGVARE--HHVLEGQEVRLDCEADGQPPPDVAWLK 2062
Query: 172 GSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITF 231
L QD G + Y G + VLK LR D +YTC N G + T
Sbjct: 2063 DGSPLG--QDMGPHLR--FYLDGGSLVLK--GLRASDAGAYTCVA--HNPAGEDARLHT- 2113
Query: 232 RLTNTTAPPALKLSVNE--TLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALA- 288
N PP +K + TLV PGE VT+ C + G P+ + W PLPL
Sbjct: 2114 --VNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPI-HVSWLKDGLPLPLSQRTL 2170
Query: 289 ---QGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQI-TPDVIK-- 342
G TL I VQ D+G + C A + G + +N T Q+ P V++
Sbjct: 2171 LHGSGHTLRISKVQLADAGIFTCVAASPAGV-----------ADRNFTLQVQVPPVLEPV 2219
Query: 343 ESEN---IQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSS 399
E +N + G ++L C VP V+ W K+G+P L++++ + P S
Sbjct: 2220 EFQNDVVVVRGSLVELPCEARGVPLPLVS--WMKDGEP-------LLSQSLEQGP----S 2266
Query: 400 LELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSP 458
L+L + D GTY C+A S G + V PP I +++ G+P
Sbjct: 2267 LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV-----MEPPHIEDSGQPTELSLTPGAP 2321
Query: 459 AELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTAR 518
EL C+ +G P+P + W + + L E R+ RV RD +G Y C
Sbjct: 2322 MELLCDAQGTPQPNITWHKDGQALTRL-------ENNSRATRVLRV-RD-AGLYTCLAES 2372
Query: 519 YNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRP---VLLRCSLLRGSPQRIASAVW 575
G E ++ VQ PP + + R +G ++L CS+ +I W
Sbjct: 2373 PAG----AIEKSFRVRVQAPPNIV-GPRGPRFVVGLAPGQLVLECSVEAEPAPKIT---W 2424
Query: 576 RFKGQLLPPPPVVPAAAEAPDHAE-LRLDAVTRDSSGSYECSVSNDVGSAACLFQV 630
G +L A + P+ L+L A++ SG Y C+ N GS + F+V
Sbjct: 2425 HRDGIVLQED----AHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRV 2476
Score = 124 bits (312), Expect = 3e-28
Identities = 150/619 (24%), Positives = 232/619 (37%), Gaps = 69/619 (11%)
Query: 14 FHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWT 73
+ C + A A+ V A + R + + EG + L C G P P V W
Sbjct: 2002 YTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWL 2061
Query: 74 KTAGSASDKFQETSVF---NETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVD-VQYL 129
K F +L ++ + + G Y C A N PA + R+ V L
Sbjct: 2062 KDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHN----PAGEDARLHTVNVL 2117
Query: 130 DEPMLTVHQTVSDVRGNFYQE--KTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIY 187
P T+ Q +D G + V + C V +PP W + L SQ
Sbjct: 2118 VPP--TIKQG-ADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRT----- 2169
Query: 188 EPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALK-LSV 246
G L++ ++ D +TC + + G+ D+ T ++ PP L+ +
Sbjct: 2170 ---LLHGSGHTLRISKVQLADAGIFTCVAA--SPAGVADRNFTLQVQ---VPPVLEPVEF 2221
Query: 247 NETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYY 306
+VV G V + C G PLP + W PL +L QG +L + +V A DSG Y
Sbjct: 2222 QNDVVVVRGSLVELPCEARGV-PLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTY 2280
Query: 307 NCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEK 366
+C A + G A++ L V + P + ++ G ++L C PQ
Sbjct: 2281 SCVAVSEAGE-ARRHFQLTVMEPPHIEDSGQPTEL----SLTPGAPMELLCDAQGTPQPN 2335
Query: 367 VTYQWFKNGKP-ARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVP 425
+T W K+G+ R+ TR L D G Y C+A P +
Sbjct: 2336 IT--WHKDGQALTRLENNSRATR---------------VLRVRDAGLYTCLAESPAGAI- 2377
Query: 426 DLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALL 485
+ S V + + PP I P+G V L+C V +P P + W R + +L
Sbjct: 2378 EKSFRVRVQA---PPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR---DGIVL 2431
Query: 486 PSGLPLEETPDGK-LRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPS 544
+ G+ L+L+ +S SG Y C G ++ + P +
Sbjct: 2432 QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAG----STSVAFRVEIHTVPTIRSG 2487
Query: 545 SQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDA 604
V ++ + LL C G P + S WR +P P P P+ LR+
Sbjct: 2488 PPAVNVSVNQTALLPCQ-ADGVPAPLVS--WR--KDRVPLDPRSPRFEILPE-GSLRIQP 2541
Query: 605 VTRDSSGSYECSVSNDVGS 623
V +G Y C SN GS
Sbjct: 2542 VLAQDAGHYLCLASNSAGS 2560
Score = 123 bits (309), Expect = 7e-28
Identities = 164/614 (26%), Positives = 237/614 (38%), Gaps = 85/614 (13%)
Query: 55 TLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF----NETLRIERIARTQGGRYYCKA 110
++ L C V HP P+V W K + + S VF TL++ R + G Y C+A
Sbjct: 1763 SVSLPCDVHAHPNPEVTWYKDSQALS---LGEEVFLLPGTHTLQLGRARLSDSGMYTCEA 1819
Query: 111 ENGVGVPAIKSIRVDV-------QYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNP 163
N G K +++ V Q P V V D L C ++ P
Sbjct: 1820 LNAAGRDQ-KLVQLSVLVPPAFRQAPRGPQDAVLVRVGD---------KAVLSCETDALP 1869
Query: 164 PARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCG 223
W + L +Q +G + L+++ + D Y+C+VS NV G
Sbjct: 1870 EPTVTWYKDGQPLVLAQRTQA-------LRGGQR-LEIQEAQVSDKGLYSCKVS--NVAG 1919
Query: 224 IPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP 283
+ TF LT PP + ET+ G + + C ++G P P + W P+
Sbjct: 1920 --EAVRTFTLT-VQVPPTFENPKTETVSQVAGSPLVLTCDVSGV-PAPTVTWLKDRMPVE 1975
Query: 284 L----GALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPD 339
G +++GG L + +Q +G Y C A N K V ++ + + I
Sbjct: 1976 SSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPR-----IRSS 2030
Query: 340 VIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTS- 398
+ ++ GQ+++L C D P V W K+G P P L
Sbjct: 2031 GVAREHHVLEGQEVRLDCEADGQPPPDVA--WLKDGSPLGQDM-------GPHLRFYLDG 2081
Query: 399 -SLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISV-PKGRAVVTVREG 456
SL L L SD G Y C+A P L VN+ VPPTI G + R G
Sbjct: 2082 GSLVLKGLRASDAGAYTCVAHNPAGEDARLHT-VNV---LVPPTIKQGADGSGTLVSRPG 2137
Query: 457 SPAELQCEVRGKPRPPVLWSRVDKEAALLP-SGLPLEETPDGKLRLERVSRDMSGTYRCQ 515
+ C VRG P V W K+ LP S L LR+ +V +G + C
Sbjct: 2138 ELVTMVCPVRGSPPIHVSWL---KDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCV 2194
Query: 516 TARYNGFNVRPREAQVQLNVQFPPEVEPSS--QDVRQALGRPVLLRCSLLRGSPQRIASA 573
A G R L VQ PP +EP DV G V L C RG P + S
Sbjct: 2195 AASPAGVADR----NFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEA-RGVPLPLVS- 2248
Query: 574 VWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
W G+ P + + + P L+L+AV SG+Y C ++ G A FQ++
Sbjct: 2249 -WMKDGE----PLLSQSLEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT-- 2298
Query: 634 AYSPEFYFDTPNPT 647
P D+ PT
Sbjct: 2299 VMEPPHIEDSGQPT 2312
Score = 120 bits (302), Expect = 5e-27
Identities = 161/614 (26%), Positives = 236/614 (38%), Gaps = 94/614 (15%)
Query: 60 CLVTGHPRPQVRWTKTAGSASDKFQE-TSVFNE-TLRIERIARTQGGRYYCKAENGVGVP 117
C G P+PQV W K S Q +V E +L + ++ G Y C+A N VG
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83
Query: 118 AIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDT-- 175
S R + P + ++V G Q T L C N P +W + +
Sbjct: 84 ---SRRAKLVVYVPPSIREDGRKANVSGMAGQSLT--LECDANGFPVPEIVWLKDAQLVG 138
Query: 176 -----------LSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGI 224
L Q G + + + ++ ++ R A + Q G+
Sbjct: 139 VPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGL 198
Query: 225 P--DKAITFRLTNTTAPPA-LKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGP 281
++ T + APP+ L + ++ G +V +QC T G P PQ++W+ P
Sbjct: 199 AGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCW-TSGVPTPQVEWTKDRQP 257
Query: 282 -LPLGALAQ----GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQI 336
LP G Q G L I D G Y C A + G A+ FQ+
Sbjct: 258 VLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARD-------------FQL 304
Query: 337 ---TPDVI---KESENIQLGQD--LKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTR 388
P I E+ + + +D ++L C VP +T WFK+G S +++ TR
Sbjct: 305 RVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT--WFKDGALLPTSTKVVYTR 362
Query: 389 NDPELPAVTSSLELIDLHFSDYGTYLCMASFP-GAPVPDLSVEVNISSETVPPTISVPKG 447
+L +L SD G Y C AS GA ++V VPPTI G
Sbjct: 363 GGRQL-------QLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY-----VPPTIEGAGG 410
Query: 448 RA-VVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKL------- 499
R VV G P L+C RG P P + W GLP+ E+ + +L
Sbjct: 411 RPYVVKAVAGRPVALECVARGHPSPTLSWHH---------EGLPVAESNESRLETDGSVL 461
Query: 500 RLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE--VEPSSQDVRQALGRPVL 557
RLE SG Y C + G V Q + VQ PP+ V V +G+P+
Sbjct: 462 RLESPGEASSGLYSCVASSPAGEAV----LQYSVEVQVPPQLLVAEGLGQVTTIVGQPLE 517
Query: 558 LRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSV 617
L C GSP + + W G+ P + A L +D V D SG + C
Sbjct: 518 LPCQA-SGSP--VPTIQWLQNGR---PAEELAGVQVASQGTTLHIDHVELDHSGLFACQA 571
Query: 618 SNDVGSAACLFQVS 631
+N+ G+A +VS
Sbjct: 572 TNEAGTAGAEVEVS 585
Score = 120 bits (301), Expect = 6e-27
Identities = 167/635 (26%), Positives = 245/635 (38%), Gaps = 98/635 (15%)
Query: 37 VVKEDNISE---RVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE-- 91
+ K+D + E + + TL L+C P P +RW K G V E
Sbjct: 1444 ISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKD-GQPVTPSSRLQVLGEGR 1502
Query: 92 TLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNF---- 147
L+I+ + GRY C A N G + V +Q PM Q V D F
Sbjct: 1503 LLQIQPTQVSDSGRYLCVATNVAGEDD-QDFNVLIQV--PPMF---QKVGDFSAAFEILS 1556
Query: 148 -----------YQE----KTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYT 192
Y+E +L C N+ PP W R LS + V
Sbjct: 1557 REEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV-------L 1609
Query: 193 QGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPAL--KLSVNETL 250
QG +VL++ +R ++ Y+C+ S + + + + L T P L + E +
Sbjct: 1610 QGG-RVLQIPLVRAENAGRYSCKASNE----VGEDWLHYELLVLTPPVILGDTEELVEEV 1664
Query: 251 VVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP----LGALAQGGTLSIPSVQARDSGYY 306
VN V++QC G +P+P + W P L L G L + + + D+ Y
Sbjct: 1665 TVNASSTVSLQCPALG-NPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASY 1723
Query: 307 NCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIK---ESENIQLGQDLKLSCHVDAVP 363
C A N G+ A+K L V Q+ P + E L + L C V A P
Sbjct: 1724 MCVAENQAGS-AEKLFTLRV--------QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHP 1774
Query: 364 QEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAP 423
+VT W+K+ + + + + + LP T +L+L SD G Y C A A
Sbjct: 1775 NPEVT--WYKDSQALSLGEEVFL------LPG-THTLQLGRARLSDSGMYTCEA-LNAAG 1824
Query: 424 VPDLSVEVNISSETVPPTI-SVPKG-RAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKE 481
V++++ VPP P+G + V VR G A L CE P P V W + +
Sbjct: 1825 RDQKLVQLSV---LVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQP 1881
Query: 482 AALLPSGLPLEETPDGKLRLERVSRDMS--GTYRCQTARYNGFNVRPREAQVQLNVQFPP 539
L L G RLE +S G Y C+ + G VR L VQ PP
Sbjct: 1882 LVLAQRTQALR----GGQRLEIQEAQVSDKGLYSCKVSNVAGEAVR----TFTLTVQVPP 1933
Query: 540 EVE-PSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAE--APD 596
E P ++ V Q G P++L C + G P A V K ++ PV +A
Sbjct: 1934 TFENPKTETVSQVAGSPLVLTCD-VSGVP---APTVTWLKDRM----PVESSAVHGVVSR 1985
Query: 597 HAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVS 631
L+L + +G+Y C N A F V+
Sbjct: 1986 GGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVA 2020
Score = 117 bits (293), Expect = 5e-26
Identities = 154/601 (25%), Positives = 224/601 (37%), Gaps = 89/601 (14%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTK-----TAGSASDKFQETSVFNETLRIERIARTQGGRYY 107
G + LQC +G P PQV WTK G + QE + LRI GRY
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQED---GQVLRITGSHVGDEGRYQ 288
Query: 108 CKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARF 167
C A + G A D Q T+ + ++ V L C P
Sbjct: 289 CVAFSPAGQQA-----RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI 343
Query: 168 IWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDK 227
W + L S + +YT+G + L+L + D YTC+ S N G +K
Sbjct: 344 TWFKDGALLPTST-------KVVYTRG-GRQLQLGRAQSSDAGVYTCKAS--NAVGAAEK 393
Query: 228 AITFRLTNTTAPPALKLSVNETLVVN--PGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG 285
A + PP ++ + VV G V ++C + G P P L W H P+
Sbjct: 394 ATRL---DVYVPPTIEGAGGRPYVVKAVAGRPVALEC-VARGHPSPTLSWHHEGLPVAES 449
Query: 286 ALAQ----GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVI 341
++ G L + S SG Y+C A++ G + + Q+ P ++
Sbjct: 450 NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ---------YSVEVQVPPQLL 500
Query: 342 KESENIQ----LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVT 397
Q +GQ L+L C P T QW +NG+PA + V T
Sbjct: 501 VAEGLGQVTTIVGQPLELPCQASGSPVP--TIQWLQNGRPAEELAGVQVASQ-----GTT 553
Query: 398 SSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGS 457
++ ++L S G + C A+ A VEV++ E P + VP G+ S
Sbjct: 554 LHIDHVELDHS--GLFACQAT-NEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHS 610
Query: 458 PAELQCEV---RG---KPRPPV---------LWSRVDKEAALLPSGLPLEETPDGKLRLE 502
C+ RG P+PP+ LW P+G+P+ + L++E
Sbjct: 611 SFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGE--------PTGIPVAYSLPPPLQIE 662
Query: 503 RVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSL 562
+V G Y C G + R +V L V PP +EP + V L C L
Sbjct: 663 KVDLRDEGIYTCAATNLAGESKR----EVALKVLVPPNIEPGPVNKAVLENASVTLEC-L 717
Query: 563 LRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVG 622
G P S W FKG P + D LR++ +GSY C SN G
Sbjct: 718 ASGVPPPDVS--W-FKGH--QPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG 772
Query: 623 S 623
S
Sbjct: 773 S 773
Score = 114 bits (286), Expect = 3e-25
Identities = 154/605 (25%), Positives = 225/605 (37%), Gaps = 79/605 (13%)
Query: 47 VYTIREG---------DTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE-TLRIE 96
V TIR G T +L C G P P V W K + + E +LRI+
Sbjct: 2481 VPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQ 2540
Query: 97 RIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLR 156
+ G Y C A N G D++ L+ P + + + + L
Sbjct: 2541 PVLAQDAGHYLCLASNSAGSDRQGR---DLRVLEPPAIAPSPSNLTLTAH----TPALLP 2593
Query: 157 CTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQV 216
C + +P +W + L G Y + L L PQD A + C V
Sbjct: 2594 CEASGSPKPLVVWWKDGQKLDFRLQQGA------YRLLPSNALLLTAPGPQDSAQFECVV 2647
Query: 217 SVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWS 276
S N G +A PP + + V V + C TG P P + WS
Sbjct: 2648 S--NEVG---EAHRLYQVTVHVPPTIADDQTDFTVTMMAP-VVLTCHSTG-IPAPTVSWS 2700
Query: 277 HGPGPLPLGALAQG------GTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMK 330
L GA G G L I +G Y C+A N+ G A K V L V++
Sbjct: 2701 KAGAQL--GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAG-VAHKHVFLTVQA-- 2755
Query: 331 NATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRND 390
+ + P V++ +++ L C +P+ +T W K G V
Sbjct: 2756 SPVVKPLPSVVRAVAE----EEVLLPCEASGIPRPTIT--WQKEGLNVATGVSTQV---- 2805
Query: 391 PELPAVTSSLELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISVPKGRA 449
LP L + D G YLC+A + G+ + + V VPP I G
Sbjct: 2806 --LPG--GQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQ-----VPPVIE--NGLP 2854
Query: 450 VVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMS 509
++ EGS A L C+ RG P P + W + + + ++ P G+L ++ + +
Sbjct: 2855 DLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQ--PSGELLVKNLEGQDA 2912
Query: 510 GTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSP-Q 568
GTY C G R R +V L + P D LG + LRC+ RGSP
Sbjct: 2913 GTYTCTAENAVG---RARR-RVHLTILVLPVFTTLPGDRSLRLGDRLWLRCA-ARGSPTP 2967
Query: 569 RIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLF 628
RI G + PV +E + L+ AV+R+ SG+Y C N VG +
Sbjct: 2968 RI--------GWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVS 3019
Query: 629 QVSAK 633
V K
Sbjct: 3020 FVHVK 3024
Score = 112 bits (279), Expect = 2e-24
Identities = 132/515 (25%), Positives = 200/515 (38%), Gaps = 82/515 (15%)
Query: 157 CTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLK-----LKNLRPQDYAS 211
C + P + W++G + EPL+ Q VL+ L ++ P D
Sbjct: 24 CGTHGTPKPQVTWRKGPSS------------EPLHGQPGVAVLEEGSLFLASVSPADSGD 71
Query: 212 YTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVN-PGENVTVQCLLTGGDPL 270
Y CQ + N G + + PP+++ + V G+++T++C G P+
Sbjct: 72 YECQAT--NEVGSTSRRAKLVVY---VPPSIREDGRKANVSGMAGQSLTLECD-ANGFPV 125
Query: 271 PQLQWSHGPG--PLPLG-----------------ALAQGGTLSIPSVQARDSGYYNCTAT 311
P++ W +PLG L +G +L P +Q SG A
Sbjct: 126 PEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAG 185
Query: 312 NNVGNPAKKTVNLLVRSMKNATFQITPDVIKE-------SENIQL-GQDLKLSCHVDAVP 363
+ A L +P E + L G D++L C VP
Sbjct: 186 GSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVP 245
Query: 364 QEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP-GA 422
+V +W K+ +P L + D ++ +T S H D G Y C+A P G
Sbjct: 246 TPQV--EWTKDRQPVLPGGPHLQVQEDGQVLRITGS------HVGDEGRYQCVAFSPAGQ 297
Query: 423 PVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEA 482
D + V+ PPTI V V E +L CE RG P P + W K+
Sbjct: 298 QARDFQLRVH-----APPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWF---KDG 349
Query: 483 ALLPSGLPLEETPDGK-LRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV 541
ALLP+ + T G+ L+L R +G Y C+ + G E +L+V PP +
Sbjct: 350 ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG----AAEKATRLDVYVPPTI 405
Query: 542 EPSSQD---VRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHA 598
E + V+ GRPV L C + RG P S W +G LP + E D +
Sbjct: 406 EGAGGRPYVVKAVAGRPVALEC-VARGHPSPTLS--WHHEG--LPVAESNESRLET-DGS 459
Query: 599 ELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
LRL++ SSG Y C S+ G A + V +
Sbjct: 460 VLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQ 494
Score = 111 bits (278), Expect = 3e-24
Identities = 151/597 (25%), Positives = 235/597 (39%), Gaps = 95/597 (15%)
Query: 48 YTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF-NETLRIERIARTQGGRY 106
+T+ ++L C TG P P V W+K + V + L I + GRY
Sbjct: 2675 FTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRY 2734
Query: 107 YCKAENGVGVPAIKSIRVDVQY--LDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPP 164
C A N GV A K + + VQ + +P+ +V + V+ E+ V L C + P
Sbjct: 2735 TCSARNSAGV-AHKHVFLTVQASPVVKPLPSVVRAVA--------EEEVLLPCEASGIPR 2785
Query: 165 ARFIWKRGSDTLSHSQDNGVDIYEPLYTQ----GETKVLKLKNLRPQDYASYTCQVSVRN 220
W Q G+++ + TQ G+ L++ + P+D +Y C +N
Sbjct: 2786 PTITW----------QKEGLNVATGVSTQVLPGGQ---LRIAHASPEDAGNYLC--IAKN 2830
Query: 221 VCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPG 280
G A+ PP ++ + + L G + + C G P P + W
Sbjct: 2831 SAG---SAMGKTRLVVQVPPVIENGLPD-LSTTEGSHAFLPCKARGS-PEPNITWDKDGQ 2885
Query: 281 PLPLGA-----LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQ 335
P+ GA + G L + +++ +D+G Y CTA N VG A++ V+L + + T
Sbjct: 2886 PVS-GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR-ARRRVHLTILVLPVFT-- 2941
Query: 336 ITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPA 395
+ +++LG L L C P ++ W N +P VT E
Sbjct: 2942 ----TLPGDRSLRLGDRLWLRCAARGSPTPRIG--WTVNDRP--------VTEGVSEQDG 2987
Query: 396 VTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVRE 455
S+L+ + D GTY+C A +S + + P V +G A + E
Sbjct: 2988 -GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF---VHVKEAP----VLQGEAFSYLVE 3039
Query: 456 --GSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLE------ETPDGKLRLERVSRD 507
G +L C VRG P P + W + GLPL + +G L + R RD
Sbjct: 3040 PVGGSIQLDCVVRGDPVPDIHW---------IKDGLPLRGSHLRHQLQNGSLTIHRTERD 3090
Query: 508 MSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSP 567
+G Y+C G + V L +Q P + QD+ G V LRC G P
Sbjct: 3091 DAGRYQCLAENEMGV----AKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT-GEP 3145
Query: 568 QRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSA 624
+ W GQ P PD L L+ V +G+Y+C N +GSA
Sbjct: 3146 T--PTIEWLQAGQ---PLRASRRLRTLPD-GSLWLENVETGDAGTYDCVAHNLLGSA 3196
Score = 107 bits (268), Expect = 4e-23
Identities = 140/560 (25%), Positives = 210/560 (37%), Gaps = 85/560 (15%)
Query: 93 LRIERIARTQGGRYYCKAENGVGVPAIK-SIRVDVQYLDEPMLTVHQTVSDVRGNFYQEK 151
L+IE++ G Y C A N G + +++V V EP V +
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP--------GPVNKAVLENA 710
Query: 152 TVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYAS 211
+V L C + PP W +G +S V + + +VL+++ + D S
Sbjct: 711 SVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSV--------DGRVLRIEQAQLSDAGS 762
Query: 212 YTCQVSVRNVCGIPDKAITFRLT---NTTAPPALKLSVNETLVVNPGENVTVQCLLTGGD 268
Y C S NV G + R+ T PP+L V LV P V + C TG
Sbjct: 763 YRCVAS--NVAGSTELRYGLRVNVPPRITLPPSLPGPV---LVNTP---VRLTCNATGA- 813
Query: 269 PLPQLQWSHGPGPLP------LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTV 322
P P L W P+ L G L++ S +A DSG Y+C A + VG + V
Sbjct: 814 PSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 873
Query: 323 NLLVRSMKNATFQITPDVIKESENIQL--GQDLKLSCHVDAVPQEKVTYQWFKNGKPARM 380
+ P ++ E N+ + + + L C A+P ++ W+K+G+P
Sbjct: 874 ---------LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS--WWKDGRP--- 919
Query: 381 SKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPP 440
L R L A + L++ D G Y C A A + +N+ V P
Sbjct: 920 ----LEPRPGVHLSADKALLQVDRADVWDAGHYTCEA-LNQAGRSEKHYNLNVWVAPVFP 974
Query: 441 TISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLR 500
+ +TVREG P L CE RG P P + W + + +GL L
Sbjct: 975 L----RESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLY 1030
Query: 501 LERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV----EPSSQDVRQALGRPV 556
L + GTY C+ + G + +QL V PP++ EP +Q V
Sbjct: 1031 LGQAQLAQEGTYTCECSNVVGNS----SQDLQLEVHVPPQIAGPREPPTQ-VSVVQDGVA 1085
Query: 557 LLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAE-----APDHAELRLDAVTRDSSG 611
L C+ P + W GQ P AE L ++ +G
Sbjct: 1086 TLECNATGKPPPTV---TWERDGQ--------PVGAELGLQLQNQGQSLHVERAQAAHTG 1134
Query: 612 SYECSVSNDVGSAACLFQVS 631
Y C N G A F++S
Sbjct: 1135 RYSCVAENLAGRAERKFELS 1154
Score = 98.6 bits (244), Expect = 2e-20
Identities = 140/618 (22%), Positives = 232/618 (37%), Gaps = 74/618 (11%)
Query: 30 VHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDK-FQETSV 88
VH + + +E N+S + +++ L+C P P + W K + S
Sbjct: 876 VHMPPSILGEELNVS-----VVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSA 930
Query: 89 FNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFY 148
L+++R G Y C+A N G + K ++V L T++ G+
Sbjct: 931 DKALLQVDRADVWDAGHYTCEALNQAG-RSEKHYNLNVWVAPVFPLRESHTLTVREGH-- 987
Query: 149 QEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQD 208
L C P + W++ L + G+ + ++L L +
Sbjct: 988 ---PTSLSCECRGVPFPKISWRKDGQPLP-GEGAGLQ-----HVSAVGRLLYLGQAQLAQ 1038
Query: 209 YASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGD 268
+YTC+ S NV G + + + + + VV G T++C TG
Sbjct: 1039 EGTYTCECS--NVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV-ATLECNATGKP 1095
Query: 269 PLPQLQWSHGPGP----LPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNL 324
P P + W P L L QG +L + QA +G Y+C A N G +K
Sbjct: 1096 P-PTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKF--- 1151
Query: 325 LVRSMKNATFQITPDVIKESENIQ-----LGQDLKLSCHVDAVPQEKVTYQWFKNGKPAR 379
+ + P++I + + + L L L C +P + +WF+ +P
Sbjct: 1152 ------ELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAI--RWFRGEEPVS 1203
Query: 380 MSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP-GAPVPDLSVEVNISSETV 438
+ D L A L++ D G Y C+AS G + SVEV V
Sbjct: 1204 PGE-------DTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV-----LV 1251
Query: 439 PPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDG- 497
PP+I V+ V +G A L C V G P+P + W K+ L G +PDG
Sbjct: 1252 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWF---KDGRPLARGDAHHISPDGV 1308
Query: 498 KLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV-----EPSSQDVRQAL 552
L++ + + +G Y C A G + QL+V P + + + ++V +
Sbjct: 1309 LLQVLQANLSSAGHYSCIAANAVG----EKTKHFQLSVLLAPTILGGAEDSADEEVTVTV 1364
Query: 553 GRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGS 612
P+ L C L I W G P P L++ ++ +G
Sbjct: 1365 NNPISLICEALAFPSPNI---TWMKDG---APFEASRNIQLLPGTHGLQILNAQKEDAGQ 1418
Query: 613 YECSVSNDVGSAACLFQV 630
Y C V+N++G A + V
Sbjct: 1419 YTCVVTNELGEAVKNYHV 1436
Score = 95.1 bits (235), Expect = 3e-19
Identities = 145/598 (24%), Positives = 224/598 (37%), Gaps = 79/598 (13%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAG--SASDKFQETSVFNETLRIERIARTQGGRYY 107
+ E + L C G P P + W K S K T L++ R + G Y
Sbjct: 323 VMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTR-GGRQLQLGRAQSSDAGVYT 381
Query: 108 CKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKT-----VFLRCTVNSN 162
CKA N VG A K+ R+DV V T+ G Y K V L C +
Sbjct: 382 CKASNAVGA-AEKATRLDVY--------VPPTIEGAGGRPYVVKAVAGRPVALECVARGH 432
Query: 163 PPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVC 222
P W ++ S ++ ++ T G VL+L++ Y+C S
Sbjct: 433 PSPTLSWHHEGLPVAESNESRLE------TDG--SVLRLESPGEASSGLYSCVAS----- 479
Query: 223 GIPDKAITFRLTNTTAPPALKLSVNETLVVN-PGENVTVQCLLTGGDPLPQLQWSHGPGP 281
+A+ PP L ++ V G+ + + C G P+P +QW P
Sbjct: 480 SPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPC-QASGSPVPTIQWLQNGRP 538
Query: 282 LP----LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQIT 337
+ +QG TL I V+ SG + C ATN G A V + V +
Sbjct: 539 AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGT-AGAEVEVSVHG------EWA 591
Query: 338 PDVIKESENIQLGQDLKLSCHVDAVP---QEKVTYQWFKNGKPARM------SKRLLVTR 388
P V++ + +GQ H + P V W + KP +
Sbjct: 592 PGVLE----VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPT 647
Query: 389 NDPELPAVTSSLELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISV-PK 446
P ++ L++ + D G Y C A + G +++++V VPP I P
Sbjct: 648 GIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKV-----LVPPNIEPGPV 702
Query: 447 GRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGK-LRLERVS 505
+AV+ E + L+C G P P V W + + + S + + + DG+ LR+E+
Sbjct: 703 NKAVL---ENASVTLECLASGVPPPDVSWFKGHQPVS---SWMGVTVSVDGRVLRIEQAQ 756
Query: 506 RDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVE-PSSQDVRQALGRPVLLRCSLLR 564
+G+YRC + G E + L V PP + P S + PV L C+
Sbjct: 757 LSDAGSYRCVASNVAG----STELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCN-AT 811
Query: 565 GSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVG 622
G+P + +W G + P P P L L + SG Y C + VG
Sbjct: 812 GAPS--PTLMWLKDGNPVSPAG-TPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG 866
Score = 93.2 bits (230), Expect = 1e-18
Identities = 137/586 (23%), Positives = 215/586 (36%), Gaps = 88/586 (15%)
Query: 57 MLQCLVTGHPRPQVRWTKTAGSASDKFQETS---VFNETLRIERIARTQGGRYYCKAENG 113
+L C +G P+P V W K + Q+ + + + L + ++ C N
Sbjct: 2591 LLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNE 2650
Query: 114 VGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFY--QEKTVFLRCTVNSNPPARFIWKR 171
VG + L + + V T++D + +F V L C P W +
Sbjct: 2651 VG---------EAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSK 2701
Query: 172 GSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAI-- 229
L ++ +G Y + L++ P YTC S RN G+ K +
Sbjct: 2702 AGAQLG-ARGSG-------YRVSPSGALEIGQALPIHAGRYTC--SARNSAGVAHKHVFL 2751
Query: 230 TFRLTNTTAP-PALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALA 288
T + + P P++ +V E V+ P E G P P + W + G
Sbjct: 2752 TVQASPVVKPLPSVVRAVAEEEVLLPCE--------ASGIPRPTITWQKEGLNVATGVST 2803
Query: 289 Q---GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESE 345
Q GG L I D+G Y C A N+ G+ KT Q+ P +
Sbjct: 2804 QVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKT---------RLVVQVPPVIENGLP 2854
Query: 346 NIQL--GQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELI 403
++ G L C P+ +T W K+G+P ++ + EL
Sbjct: 2855 DLSTTEGSHAFLPCKARGSPEPNIT--WDKDGQPVSGAEGKFTIQPSGELLVK------- 2905
Query: 404 DLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQC 463
+L D GTY C A V V+++ +P ++P R++ R G L+C
Sbjct: 2906 NLEGQDAGTYTCTAE---NAVGRARRRVHLTILVLPVFTTLPGDRSL---RLGDRLWLRC 2959
Query: 464 EVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFN 523
RG P P + W+ D+ S E+ L+ VSR+ SGTY C G
Sbjct: 2960 AARGSPTPRIGWTVNDRPVTEGVS----EQDGGSTLQRAAVSREDSGTYVCWAENRVGRT 3015
Query: 524 -----VRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFK 578
V +EA V F VEP +G + L C ++RG P + W
Sbjct: 3016 QAVSFVHVKEAPVLQGEAFSYLVEP--------VGGSIQLDC-VVRGDP--VPDIHWIKD 3064
Query: 579 GQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSA 624
G L + + L + RD +G Y+C N++G A
Sbjct: 3065 GLPLRGSHL----RHQLQNGSLTIHRTERDDAGRYQCLAENEMGVA 3106
Score = 92.0 bits (227), Expect = 2e-18
Identities = 146/628 (23%), Positives = 223/628 (35%), Gaps = 86/628 (13%)
Query: 40 EDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGS-ASDKFQETSVFNETLRIERI 98
E+ E V + +G T L C VTGHP+P++ W K A S L++ +
Sbjct: 1256 ENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQA 1315
Query: 99 ARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCT 158
+ G Y C A N VG K ++ V L +L + +D + L C
Sbjct: 1316 NLSSAGHYSCIAANAVG-EKTKHFQLSV-LLAPTILGGAEDSADEEVTVTVNNPISLICE 1373
Query: 159 VNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSV 218
+ P W + S++ + T L++ N + +D YTC V+
Sbjct: 1374 ALAFPSPNITWMKDGAPFEASRN--------IQLLPGTHGLQILNAQKEDAGQYTCVVT- 1424
Query: 219 RNVCGIPDKAITFRLTNTTAPPAL-------KLSVNETLVVNPGENVTVQCLLTGGDPLP 271
N G +A+ PP++ ++ V E + +T++C + P P
Sbjct: 1425 -NELG---EAVKNYHVEVLIPPSISKDDPLGEVGVKE-VKTKVNSTLTLEC-ESWAVPPP 1478
Query: 272 QLQWSHGPGPLP----LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVR 327
++W P+ L L +G L I Q DSG Y C ATN G + N+L++
Sbjct: 1479 TIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGED-DQDFNVLIQ 1537
Query: 328 ----SMKNATFQITPDVIKESENIQLG----------QDLKLSCHVDAVPQEKVTYQWFK 373
K F +++ E + G L C +A+P +T W++
Sbjct: 1538 VPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLT--WYR 1595
Query: 374 NGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNI 433
+P + V + L++ + + G Y C AS L E+ +
Sbjct: 1596 EDQPLSAGDEVSVLQGG-------RVLQIPLVRAENAGRYSCKAS-NEVGEDWLHYELLV 1647
Query: 434 SSETVPPTISVPKGRAV--VTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPL 491
PP I V VTV S LQC G P P + W L +GLP
Sbjct: 1648 ---LTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW---------LQNGLPF 1695
Query: 492 EETP------DGK-LRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEP- 543
+P DG+ L++ + +Y C G E L VQ PP +
Sbjct: 1696 SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG----SAEKLFTLRVQVPPRIAGL 1751
Query: 544 SSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLD 603
+ V L V L C + P W Q L + P L+L
Sbjct: 1752 DLEQVTAILNSSVSLPCD-VHAHPN--PEVTWYKDSQAL---SLGEEVFLLPGTHTLQLG 1805
Query: 604 AVTRDSSGSYECSVSNDVGSAACLFQVS 631
SG Y C N G L Q+S
Sbjct: 1806 RARLSDSGMYTCEALNAAGRDQKLVQLS 1833
Score = 72.8 bits (177), Expect = 1e-12
Identities = 72/285 (25%), Positives = 115/285 (40%), Gaps = 33/285 (11%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYC 108
++R GD L L+C G P P++ WT ++ E TL+ ++R G Y C
Sbjct: 2948 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDG-GSTLQRAAVSREDSGTYVC 3006
Query: 109 KAENGVGVPAIKSIRVDVQYLDEPML---TVHQTVSDVRGNFYQEKTVFLRCTVNSNPPA 165
AEN VG S V + P+L V V G+ + L C V +P
Sbjct: 3007 WAENRVGRTQAVSF---VHVKEAPVLQGEAFSYLVEPVGGS------IQLDCVVRGDPVP 3057
Query: 166 RFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIP 225
W + L S L Q + L + D Y C N G+
Sbjct: 3058 DIHWIKDGLPLRGSH---------LRHQLQNGSLTIHRTERDDAGRYQCLAE--NEMGVA 3106
Query: 226 DKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG 285
K + L + P ++ + + V G++V ++C TG +P P ++W PL
Sbjct: 3107 KKVVILVLQSA---PVFQVEPQD-MTVRSGDDVALRCQATG-EPTPTIEWLQAGQPLRAS 3161
Query: 286 ALAQ---GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVR 327
+ G+L + +V+ D+G Y+C A N +G+ + L+VR
Sbjct: 3162 RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAF-LVVR 3205
Score = 55.1 bits (131), Expect = 3e-07
Identities = 44/151 (29%), Positives = 62/151 (41%), Gaps = 9/151 (5%)
Query: 30 VHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF 89
VH +A V++ + S V + G ++ L C+V G P P + W K +
Sbjct: 3021 VHVKEAPVLQGEAFSYLVEPV--GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQ 3078
Query: 90 NETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQ 149
N +L I R R GRY C AEN +GV A K + + +Q P+ V VR
Sbjct: 3079 NGSLTIHRTERDDAGRYQCLAENEMGV-AKKVVILVLQ--SAPVFQVEPQDMTVRSG--- 3132
Query: 150 EKTVFLRCTVNSNPPARFIWKRGSDTLSHSQ 180
V LRC P W + L S+
Sbjct: 3133 -DDVALRCQATGEPTPTIEWLQAGQPLRASR 3162
Score = 41.6 bits (96), Expect = 0.004
Identities = 24/111 (21%), Positives = 48/111 (43%), Gaps = 2/111 (1%)
Query: 14 FHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWT 73
+ C + A+ ++ Q+ V + + + T+R GD + L+C TG P P + W
Sbjct: 3095 YQCLAENEMGVAKKVVILVLQSAPVFQ--VEPQDMTVRSGDDVALRCQATGEPTPTIEWL 3152
Query: 74 KTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRV 124
+ + ++ + +L +E + G Y C A N +G ++ V
Sbjct: 3153 QAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLV 3203
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 139 bits (351), Expect = 1e-32
Identities = 166/602 (27%), Positives = 238/602 (39%), Gaps = 84/602 (13%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF--NETLRIERIARTQGGRYY 107
+R GD +L C P P V W K G Q T + L I+ + G Y
Sbjct: 1762 VRVGDKAVLSCETDALPEPTVTWYKD-GQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYS 1820
Query: 108 CKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARF 167
CK N G A+++ + VQ +TVS V G+ + L C V+ P
Sbjct: 1821 CKVSNVAG-EAVRTFTLTVQVPPTFENPKTETVSQVAGS-----PLVLTCDVSGVPAPTV 1874
Query: 168 IWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDK 227
W + + S +GV ++G L+L L+P +YTC D
Sbjct: 1875 TWLKDRMPVESSAVHGV------VSRGGR--LQLSRLQPAQAGTYTCVAENTQAEARKD- 1925
Query: 228 AITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPL----- 282
F + AP V V G+ V + C G P P + W PL
Sbjct: 1926 ---FVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC-EADGQPPPDVAWLKDGSPLGQDMG 1981
Query: 283 -PLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAK-KTVNLLVRSMKNATFQITPDV 340
L GG+L + ++A D+G Y C A N G A+ TVN+LV P
Sbjct: 1982 PHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV-----------PPT 2030
Query: 341 IKESEN------IQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELP 394
IK+ + + G+ + + C V P V+ W K+G P +S+R L L
Sbjct: 2031 IKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVS--WLKDGLPLPLSQRTL-------LH 2081
Query: 395 AVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVR 454
+L + + +D G + C+A+ P A V D + + + VPP + + + V V
Sbjct: 2082 GSGHTLRISKVQLADAGIFTCVAASP-AGVADRNFTLQVQ---VPPVLEPVEFQNDVVVV 2137
Query: 455 EGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRC 514
GS EL CE RG P P V W + D E L S LE+ P L+LE V SGTY C
Sbjct: 2138 RGSLVELPCEARGVPLPLVSWMK-DGEPLLSQS---LEQGP--SLQLEAVGAGDSGTYSC 2191
Query: 515 QTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQAL--GRPVLLRCSLLRGSPQRIAS 572
G QL V PP +E S Q +L G P+ L C +G+PQ +
Sbjct: 2192 VAVSEAG----EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCD-AQGTPQ--PN 2244
Query: 573 AVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSA 632
W GQ A +++ RD +G Y C + G+ F+V
Sbjct: 2245 ITWHKDGQ---------ALTRLENNSRATRVLRVRD-AGLYTCLAESPAGAIEKSFRVRV 2294
Query: 633 KA 634
+A
Sbjct: 2295 QA 2296
Score = 132 bits (331), Expect = 2e-30
Identities = 159/595 (26%), Positives = 238/595 (40%), Gaps = 67/595 (11%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQET-SVFNETLRIERIARTQGGRYYC 108
+ E ++ L+CL +G P P V W K S T SV LRIE+ + G Y C
Sbjct: 615 VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRC 674
Query: 109 KAENGVGVPAIK-SIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARF 167
A N G ++ +RV+V P +T+ ++ G V L C P
Sbjct: 675 VASNVAGSTELRYGLRVNV----PPRITLPPSLP---GPVLVNTPVRLTCNATGAPSPTL 727
Query: 168 IWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDK 227
+W + + +S + G+ ++ +VL L + R D Y+C V + +
Sbjct: 728 MWLKDGNPVSPAGTPGLQVFP------GGRVLTLASARASDSGRYSCVA----VSAVGED 777
Query: 228 AITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP---- 283
L P L +N ++V N E+V ++C + P P L W PL
Sbjct: 778 RQDVVLQVHMPPSILGEELNVSVVAN--ESVALEC-QSHAMPPPVLSWWKDGRPLEPRPG 834
Query: 284 LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKE 343
+ A L + D+G+Y C A N G+ ++K NL V + P
Sbjct: 835 VHLSADKALLQVDRADVWDAGHYTCEALNQAGH-SEKHYNLNV-----WVAPVFPLRESH 888
Query: 344 SENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELI 403
+ ++ G +LSC VP K++ W K+G+P L + AV L L
Sbjct: 889 TLTVREGHPTRLSCECRGVPFPKIS--WRKDGQPLPGEGAGL-----QHVSAVGRLLYLG 941
Query: 404 DLHFSDYGTYLCMAS-FPGAPVPDLSVEVNISSETVPPTISVPKGRAV-VTVREGSPAEL 461
+ GTY C S G DL +EV+ VPP I+ P+ V+V + A L
Sbjct: 942 QAQLAQEGTYTCECSNVVGNSSQDLQLEVH-----VPPQIAGPREPPTQVSVVQDGVATL 996
Query: 462 QCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNG 521
+C GKP P V W R D + GL L+ L +ER +G Y C G
Sbjct: 997 ECNATGKPPPTVTWER-DGQPVGAELGLQLQNQGQ-SLHVERAQAAHTGRYSCVAENLAG 1054
Query: 522 FNVRPREAQVQLNVQFPPE----VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRF 577
E + +L+V PPE ++P + ++ AL P+ L C + P I W F
Sbjct: 1055 ----RAERKFELSVLVPPELIGDLDPLT-NITAALHSPLTLLCEAMGIPPPAIR---W-F 1105
Query: 578 KGQLLPPPPVVPAAAE--APDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQV 630
+G+ PV P L++ SG Y C SN+ G A F V
Sbjct: 1106 RGE----EPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSV 1156
Score = 125 bits (314), Expect = 2e-28
Identities = 164/596 (27%), Positives = 240/596 (40%), Gaps = 85/596 (14%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE-TLRIERIARTQGGRYYCKAE 111
G L+L C V+G P P V W K V L++ R+ Q G Y C AE
Sbjct: 1857 GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAE 1916
Query: 112 NGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKR 171
N A K V V L P + + + + + V L C + PP W +
Sbjct: 1917 N-TQAEARKDFVVAV--LVAPRIRSSGVARE--HHVLEGQEVRLDCEADGQPPPDVAWLK 1971
Query: 172 GSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITF 231
L QD G + Y G + VLK LR D +YTC N G + T
Sbjct: 1972 DGSPLG--QDMGPHLR--FYLDGGSLVLK--GLRASDAGAYTCVA--HNPAGEDARLHT- 2022
Query: 232 RLTNTTAPPALKLSVNE--TLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALA- 288
N PP +K + TLV PGE VT+ C + G P+ + W PLPL
Sbjct: 2023 --VNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPI-HVSWLKDGLPLPLSQRTL 2079
Query: 289 ---QGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQI-TPDVIK-- 342
G TL I VQ D+G + C A + G + +N T Q+ P V++
Sbjct: 2080 LHGSGHTLRISKVQLADAGIFTCVAASPAGV-----------ADRNFTLQVQVPPVLEPV 2128
Query: 343 ESEN---IQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSS 399
E +N + G ++L C VP V+ W K+G+P L++++ + P S
Sbjct: 2129 EFQNDVVVVRGSLVELPCEARGVPLPLVS--WMKDGEP-------LLSQSLEQGP----S 2175
Query: 400 LELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSP 458
L+L + D GTY C+A S G + V PP I +++ G+P
Sbjct: 2176 LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV-----MEPPHIEDSGQPTELSLTPGAP 2230
Query: 459 AELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTAR 518
EL C+ +G P+P + W + + L E R+ RV RD +G Y C
Sbjct: 2231 MELLCDAQGTPQPNITWHKDGQALTRL-------ENNSRATRVLRV-RD-AGLYTCLAES 2281
Query: 519 YNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRP---VLLRCSLLRGSPQRIASAVW 575
G E ++ VQ PP + + R +G ++L CS+ +I W
Sbjct: 2282 PAG----AIEKSFRVRVQAPPNIV-GPRGPRFVVGLAPGQLVLECSVEAEPAPKIT---W 2333
Query: 576 RFKGQLLPPPPVVPAAAEAPDHAE-LRLDAVTRDSSGSYECSVSNDVGSAACLFQV 630
G +L A + P+ L+L A++ SG Y C+ N GS + F+V
Sbjct: 2334 HRDGIVLQED----AHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRV 2385
Score = 125 bits (313), Expect = 2e-28
Identities = 122/430 (28%), Positives = 183/430 (42%), Gaps = 67/430 (15%)
Query: 234 TNTTAPPALKLSVNETLVVN-PGENVTVQCLLTGGDPLPQLQWSHGPG--PLPLG----- 285
T + PP+++ + V G+++T++C G P+P++ W +PLG
Sbjct: 11 TGSVVPPSIREDGRKANVSGMAGQSLTLECD-ANGFPVPEIVWLKDAQLVGVPLGWAGYG 69
Query: 286 ------------ALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNAT 333
L +G +L P +Q DSG Y+C A N G A++ +LLV
Sbjct: 70 WDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGT-AQRDFHLLV------- 121
Query: 334 FQITPDVIKESENIQ-----LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTR 388
+TP + + Q G D++L C VP +V +W K+ +P L +
Sbjct: 122 --LTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQV--EWTKDRQPVLPGGPHLQVQ 177
Query: 389 NDPELPAVTSSLELIDLHFSDYGTYLCMASFP-GAPVPDLSVEVNISSETVPPTISVPKG 447
D ++ +T S H D G Y C+A P G D + V+ PPTI
Sbjct: 178 EDGQVLRITGS------HVGDEGRYQCVAFSPAGQQARDFQLRVH-----APPTIWGSNE 226
Query: 448 RAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGK-LRLERVSR 506
V V E +L CE RG P P + W K+ ALLP+ + T G+ L+L R
Sbjct: 227 TGEVAVMEDHLVQLLCEARGVPTPNITWF---KDGALLPTSTKVVYTRGGRQLQLGRAQS 283
Query: 507 DMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSS---QDVRQALGRPVLLRCSLL 563
+G Y C+ + G E +L+V PP +E + V+ GRPV L C +
Sbjct: 284 SDAGVYTCKASNAVG----AAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALEC-VA 338
Query: 564 RGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGS 623
RG P S W +G LP + E D + LRL++ SSG Y C S+ G
Sbjct: 339 RGHPSPTLS--WHHEG--LPVAESNESRLET-DGSVLRLESPGEASSGLYSCVASSPAGE 393
Query: 624 AACLFQVSAK 633
A + V +
Sbjct: 394 AVLQYSVEVQ 403
Score = 124 bits (312), Expect = 3e-28
Identities = 150/619 (24%), Positives = 232/619 (37%), Gaps = 69/619 (11%)
Query: 14 FHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWT 73
+ C + A A+ V A + R + + EG + L C G P P V W
Sbjct: 1911 YTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWL 1970
Query: 74 KTAGSASDKFQETSVF---NETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVD-VQYL 129
K F +L ++ + + G Y C A N PA + R+ V L
Sbjct: 1971 KDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHN----PAGEDARLHTVNVL 2026
Query: 130 DEPMLTVHQTVSDVRGNFYQE--KTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIY 187
P T+ Q +D G + V + C V +PP W + L SQ
Sbjct: 2027 VPP--TIKQG-ADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRT----- 2078
Query: 188 EPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALK-LSV 246
G L++ ++ D +TC + + G+ D+ T ++ PP L+ +
Sbjct: 2079 ---LLHGSGHTLRISKVQLADAGIFTCVAA--SPAGVADRNFTLQVQ---VPPVLEPVEF 2130
Query: 247 NETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYY 306
+VV G V + C G PLP + W PL +L QG +L + +V A DSG Y
Sbjct: 2131 QNDVVVVRGSLVELPCEARGV-PLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTY 2189
Query: 307 NCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEK 366
+C A + G A++ L V + P + ++ G ++L C PQ
Sbjct: 2190 SCVAVSEAGE-ARRHFQLTVMEPPHIEDSGQPTEL----SLTPGAPMELLCDAQGTPQPN 2244
Query: 367 VTYQWFKNGKP-ARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVP 425
+T W K+G+ R+ TR L D G Y C+A P +
Sbjct: 2245 IT--WHKDGQALTRLENNSRATR---------------VLRVRDAGLYTCLAESPAGAI- 2286
Query: 426 DLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALL 485
+ S V + + PP I P+G V L+C V +P P + W R + +L
Sbjct: 2287 EKSFRVRVQA---PPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR---DGIVL 2340
Query: 486 PSGLPLEETPDGK-LRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPS 544
+ G+ L+L+ +S SG Y C G ++ + P +
Sbjct: 2341 QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAG----STSVAFRVEIHTVPTIRSG 2396
Query: 545 SQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDA 604
V ++ + LL C G P + S WR +P P P P+ LR+
Sbjct: 2397 PPAVNVSVNQTALLPCQ-ADGVPAPLVS--WR--KDRVPLDPRSPRFEILPE-GSLRIQP 2450
Query: 605 VTRDSSGSYECSVSNDVGS 623
V +G Y C SN GS
Sbjct: 2451 VLAQDAGHYLCLASNSAGS 2469
Score = 123 bits (309), Expect = 7e-28
Identities = 164/614 (26%), Positives = 237/614 (38%), Gaps = 85/614 (13%)
Query: 55 TLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF----NETLRIERIARTQGGRYYCKA 110
++ L C V HP P+V W K + + S VF TL++ R + G Y C+A
Sbjct: 1672 SVSLPCDVHAHPNPEVTWYKDSQALS---LGEEVFLLPGTHTLQLGRARLSDSGMYTCEA 1728
Query: 111 ENGVGVPAIKSIRVDV-------QYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNP 163
N G K +++ V Q P V V D L C ++ P
Sbjct: 1729 LNAAGRDQ-KLVQLSVLVPPAFRQAPRGPQDAVLVRVGD---------KAVLSCETDALP 1778
Query: 164 PARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCG 223
W + L +Q +G + L+++ + D Y+C+VS NV G
Sbjct: 1779 EPTVTWYKDGQPLVLAQRTQA-------LRGGQR-LEIQEAQVSDKGLYSCKVS--NVAG 1828
Query: 224 IPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP 283
+ TF LT PP + ET+ G + + C ++G P P + W P+
Sbjct: 1829 --EAVRTFTLT-VQVPPTFENPKTETVSQVAGSPLVLTCDVSGV-PAPTVTWLKDRMPVE 1884
Query: 284 L----GALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPD 339
G +++GG L + +Q +G Y C A N K V ++ + + I
Sbjct: 1885 SSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPR-----IRSS 1939
Query: 340 VIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTS- 398
+ ++ GQ+++L C D P V W K+G P P L
Sbjct: 1940 GVAREHHVLEGQEVRLDCEADGQPPPDVA--WLKDGSPLGQDM-------GPHLRFYLDG 1990
Query: 399 -SLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISV-PKGRAVVTVREG 456
SL L L SD G Y C+A P L VN+ VPPTI G + R G
Sbjct: 1991 GSLVLKGLRASDAGAYTCVAHNPAGEDARLHT-VNV---LVPPTIKQGADGSGTLVSRPG 2046
Query: 457 SPAELQCEVRGKPRPPVLWSRVDKEAALLP-SGLPLEETPDGKLRLERVSRDMSGTYRCQ 515
+ C VRG P V W K+ LP S L LR+ +V +G + C
Sbjct: 2047 ELVTMVCPVRGSPPIHVSWL---KDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCV 2103
Query: 516 TARYNGFNVRPREAQVQLNVQFPPEVEPSS--QDVRQALGRPVLLRCSLLRGSPQRIASA 573
A G R L VQ PP +EP DV G V L C RG P + S
Sbjct: 2104 AASPAGVADR----NFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEA-RGVPLPLVS- 2157
Query: 574 VWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
W G+ P + + + P L+L+AV SG+Y C ++ G A FQ++
Sbjct: 2158 -WMKDGE----PLLSQSLEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT-- 2207
Query: 634 AYSPEFYFDTPNPT 647
P D+ PT
Sbjct: 2208 VMEPPHIEDSGQPT 2221
Score = 120 bits (302), Expect = 5e-27
Identities = 167/635 (26%), Positives = 246/635 (38%), Gaps = 98/635 (15%)
Query: 37 VVKEDNISE---RVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE-- 91
+ K+D ++E + + TL L+C P P +RW K G V E
Sbjct: 1353 ISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKD-GQPVTPSSRLQVLGEGR 1411
Query: 92 TLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNF---- 147
L+I+ + GRY C A N G + V +Q PM Q V D F
Sbjct: 1412 LLQIQPTQVSDSGRYLCVATNVAGEDD-QDFNVLIQV--PPMF---QKVGDFSAAFEILS 1465
Query: 148 -----------YQE----KTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYT 192
Y+E +L C N+ PP W R LS + V
Sbjct: 1466 REEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV-------L 1518
Query: 193 QGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPAL--KLSVNETL 250
QG +VL++ +R ++ Y+C+ S + + + + L T P L + E +
Sbjct: 1519 QGG-RVLQIPLVRAENAGRYSCKASNE----VGEDWLHYELLVLTPPVILGDTEELVEEV 1573
Query: 251 VVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP----LGALAQGGTLSIPSVQARDSGYY 306
VN V++QC G +P+P + W P L L G L + + + D+ Y
Sbjct: 1574 TVNASSTVSLQCPALG-NPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASY 1632
Query: 307 NCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIK---ESENIQLGQDLKLSCHVDAVP 363
C A N G+ A+K L V Q+ P + E L + L C V A P
Sbjct: 1633 MCVAENQAGS-AEKLFTLRV--------QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHP 1683
Query: 364 QEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAP 423
+VT W+K+ + + + + + LP T +L+L SD G Y C A A
Sbjct: 1684 NPEVT--WYKDSQALSLGEEVFL------LPG-THTLQLGRARLSDSGMYTCEA-LNAAG 1733
Query: 424 VPDLSVEVNISSETVPPTI-SVPKG-RAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKE 481
V++++ VPP P+G + V VR G A L CE P P V W + +
Sbjct: 1734 RDQKLVQLSV---LVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQP 1790
Query: 482 AALLPSGLPLEETPDGKLRLERVSRDMS--GTYRCQTARYNGFNVRPREAQVQLNVQFPP 539
L L G RLE +S G Y C+ + G VR L VQ PP
Sbjct: 1791 LVLAQRTQALR----GGQRLEIQEAQVSDKGLYSCKVSNVAGEAVR----TFTLTVQVPP 1842
Query: 540 EVE-PSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAE--APD 596
E P ++ V Q G P++L C + G P A V K ++ PV +A
Sbjct: 1843 TFENPKTETVSQVAGSPLVLTCD-VSGVP---APTVTWLKDRM----PVESSAVHGVVSR 1894
Query: 597 HAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVS 631
L+L + +G+Y C N A F V+
Sbjct: 1895 GGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVA 1929
Score = 117 bits (293), Expect = 5e-26
Identities = 154/601 (25%), Positives = 224/601 (37%), Gaps = 89/601 (14%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTK-----TAGSASDKFQETSVFNETLRIERIARTQGGRYY 107
G + LQC +G P PQV WTK G + QE + LRI GRY
Sbjct: 141 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQED---GQVLRITGSHVGDEGRYQ 197
Query: 108 CKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARF 167
C A + G A D Q T+ + ++ V L C P
Sbjct: 198 CVAFSPAGQQA-----RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI 252
Query: 168 IWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDK 227
W + L S + +YT+G + L+L + D YTC+ S N G +K
Sbjct: 253 TWFKDGALLPTST-------KVVYTRG-GRQLQLGRAQSSDAGVYTCKAS--NAVGAAEK 302
Query: 228 AITFRLTNTTAPPALKLSVNETLVVN--PGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG 285
A + PP ++ + VV G V ++C + G P P L W H P+
Sbjct: 303 ATRL---DVYVPPTIEGAGGRPYVVKAVAGRPVALEC-VARGHPSPTLSWHHEGLPVAES 358
Query: 286 ALAQ----GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVI 341
++ G L + S SG Y+C A++ G + + Q+ P ++
Sbjct: 359 NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ---------YSVEVQVPPQLL 409
Query: 342 KESENIQ----LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVT 397
Q +GQ L+L C P T QW +NG+PA + V T
Sbjct: 410 VAEGLGQVTTIVGQPLELPCQASGSPVP--TIQWLQNGRPAEELAGVQVASQ-----GTT 462
Query: 398 SSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGS 457
++ ++L S G + C A+ A VEV++ E P + VP G+ S
Sbjct: 463 LHIDHVELDHS--GLFACQAT-NEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHS 519
Query: 458 PAELQCEV---RG---KPRPPV---------LWSRVDKEAALLPSGLPLEETPDGKLRLE 502
C+ RG P+PP+ LW P+G+P+ + L++E
Sbjct: 520 SFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGE--------PTGIPVAYSLPPPLQIE 571
Query: 503 RVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSL 562
+V G Y C G + R +V L V PP +EP + V L C L
Sbjct: 572 KVDLRDEGIYTCAATNLAGESKR----EVALKVLVPPNIEPGPVNKAVLENASVTLEC-L 626
Query: 563 LRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVG 622
G P S W FKG P + D LR++ +GSY C SN G
Sbjct: 627 ASGVPPPDVS--W-FKGH--QPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG 681
Query: 623 S 623
S
Sbjct: 682 S 682
Score = 115 bits (288), Expect = 2e-25
Identities = 136/512 (26%), Positives = 198/512 (38%), Gaps = 82/512 (16%)
Query: 151 KTVFLRCTVNSNPPARFIWKRGSDTLS-------HSQDNGVDIYEPLYTQGETKVLKLKN 203
+++ L C N P +W + + + + D G E + L
Sbjct: 34 QSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPR 93
Query: 204 LRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCL 263
++ D Y+C+ N G + F L T P L + ++ G +V +QC
Sbjct: 94 IQEGDSGLYSCRAE--NQAGTAQR--DFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCW 149
Query: 264 LTGGDPLPQLQWSHGPGP-LPLGALAQ----GGTLSIPSVQARDSGYYNCTATNNVGNPA 318
T G P PQ++W+ P LP G Q G L I D G Y C A + G A
Sbjct: 150 -TSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQA 208
Query: 319 KKTVNLLVRSMKNATFQI---TPDVI---KESENIQLGQD--LKLSCHVDAVPQEKVTYQ 370
+ FQ+ P I E+ + + +D ++L C VP +T
Sbjct: 209 RD-------------FQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT-- 253
Query: 371 WFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP-GAPVPDLSV 429
WFK+G S +++ TR +L +L SD G Y C AS GA +
Sbjct: 254 WFKDGALLPTSTKVVYTRGGRQL-------QLGRAQSSDAGVYTCKASNAVGAAEKATRL 306
Query: 430 EVNISSETVPPTISVPKGRA-VVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSG 488
+V VPPTI GR VV G P L+C RG P P + W G
Sbjct: 307 DVY-----VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHH---------EG 352
Query: 489 LPLEETPDGKL-------RLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE- 540
LP+ E+ + +L RLE SG Y C + G V Q + VQ PP+
Sbjct: 353 LPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAV----LQYSVEVQVPPQL 408
Query: 541 -VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAE 599
V V +G+P+ L C GSP + + W G+ P + A
Sbjct: 409 LVAEGLGQVTTIVGQPLELPCQA-SGSP--VPTIQWLQNGR---PAEELAGVQVASQGTT 462
Query: 600 LRLDAVTRDSSGSYECSVSNDVGSAACLFQVS 631
L +D V D SG + C +N+ G+A +VS
Sbjct: 463 LHIDHVELDHSGLFACQATNEAGTAGAEVEVS 494
Score = 114 bits (286), Expect = 3e-25
Identities = 154/605 (25%), Positives = 225/605 (37%), Gaps = 79/605 (13%)
Query: 47 VYTIREG---------DTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE-TLRIE 96
V TIR G T +L C G P P V W K + + E +LRI+
Sbjct: 2390 VPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQ 2449
Query: 97 RIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLR 156
+ G Y C A N G D++ L+ P + + + + L
Sbjct: 2450 PVLAQDAGHYLCLASNSAGSDRQGR---DLRVLEPPAIAPSPSNLTLTAH----TPALLP 2502
Query: 157 CTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQV 216
C + +P +W + L G Y + L L PQD A + C V
Sbjct: 2503 CEASGSPKPLVVWWKDGQKLDFRLQQGA------YRLLPSNALLLTAPGPQDSAQFECVV 2556
Query: 217 SVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWS 276
S N G +A PP + + V V + C TG P P + WS
Sbjct: 2557 S--NEVG---EAHRLYQVTVHVPPTIADDQTDFTVTMMAP-VVLTCHSTG-IPAPTVSWS 2609
Query: 277 HGPGPLPLGALAQG------GTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMK 330
L GA G G L I +G Y C+A N+ G A K V L V++
Sbjct: 2610 KAGAQL--GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAG-VAHKHVFLTVQA-- 2664
Query: 331 NATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRND 390
+ + P V++ +++ L C +P+ +T W K G V
Sbjct: 2665 SPVVKPLPSVVRAVAE----EEVLLPCEASGIPRPTIT--WQKEGLNVATGVSTQV---- 2714
Query: 391 PELPAVTSSLELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISVPKGRA 449
LP L + D G YLC+A + G+ + + V VPP I G
Sbjct: 2715 --LPG--GQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQ-----VPPVIE--NGLP 2763
Query: 450 VVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMS 509
++ EGS A L C+ RG P P + W + + + ++ P G+L ++ + +
Sbjct: 2764 DLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQ--PSGELLVKNLEGQDA 2821
Query: 510 GTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSP-Q 568
GTY C G R R +V L + P D LG + LRC+ RGSP
Sbjct: 2822 GTYTCTAENAVG---RARR-RVHLTILVLPVFTTLPGDRSLRLGDRLWLRCA-ARGSPTP 2876
Query: 569 RIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLF 628
RI G + PV +E + L+ AV+R+ SG+Y C N VG +
Sbjct: 2877 RI--------GWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVS 2928
Query: 629 QVSAK 633
V K
Sbjct: 2929 FVHVK 2933
Score = 111 bits (278), Expect = 3e-24
Identities = 151/597 (25%), Positives = 235/597 (39%), Gaps = 95/597 (15%)
Query: 48 YTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF-NETLRIERIARTQGGRY 106
+T+ ++L C TG P P V W+K + V + L I + GRY
Sbjct: 2584 FTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRY 2643
Query: 107 YCKAENGVGVPAIKSIRVDVQY--LDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPP 164
C A N GV A K + + VQ + +P+ +V + V+ E+ V L C + P
Sbjct: 2644 TCSARNSAGV-AHKHVFLTVQASPVVKPLPSVVRAVA--------EEEVLLPCEASGIPR 2694
Query: 165 ARFIWKRGSDTLSHSQDNGVDIYEPLYTQ----GETKVLKLKNLRPQDYASYTCQVSVRN 220
W Q G+++ + TQ G+ L++ + P+D +Y C +N
Sbjct: 2695 PTITW----------QKEGLNVATGVSTQVLPGGQ---LRIAHASPEDAGNYLC--IAKN 2739
Query: 221 VCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPG 280
G A+ PP ++ + + L G + + C G P P + W
Sbjct: 2740 SAG---SAMGKTRLVVQVPPVIENGLPD-LSTTEGSHAFLPCKARGS-PEPNITWDKDGQ 2794
Query: 281 PLPLGA-----LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQ 335
P+ GA + G L + +++ +D+G Y CTA N VG A++ V+L + + T
Sbjct: 2795 PVS-GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR-ARRRVHLTILVLPVFT-- 2850
Query: 336 ITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPA 395
+ +++LG L L C P ++ W N +P VT E
Sbjct: 2851 ----TLPGDRSLRLGDRLWLRCAARGSPTPRIG--WTVNDRP--------VTEGVSEQDG 2896
Query: 396 VTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVRE 455
S+L+ + D GTY+C A +S + + P V +G A + E
Sbjct: 2897 -GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF---VHVKEAP----VLQGEAFSYLVE 2948
Query: 456 --GSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLE------ETPDGKLRLERVSRD 507
G +L C VRG P P + W + GLPL + +G L + R RD
Sbjct: 2949 PVGGSIQLDCVVRGDPVPDIHW---------IKDGLPLRGSHLRHQLQNGSLTIRRTERD 2999
Query: 508 MSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSP 567
+G Y+C G + V L +Q P + QD+ G V LRC G P
Sbjct: 3000 DAGRYQCLAENEMGV----AKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT-GEP 3054
Query: 568 QRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSA 624
+ W GQ P PD L L+ V +G+Y+C N +GSA
Sbjct: 3055 T--PTIEWLQAGQ---PLRASRRLRTLPD-GSLWLENVETGDAGTYDCVAHNLLGSA 3105
Score = 107 bits (268), Expect = 4e-23
Identities = 140/560 (25%), Positives = 210/560 (37%), Gaps = 85/560 (15%)
Query: 93 LRIERIARTQGGRYYCKAENGVGVPAIK-SIRVDVQYLDEPMLTVHQTVSDVRGNFYQEK 151
L+IE++ G Y C A N G + +++V V EP V +
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP--------GPVNKAVLENA 619
Query: 152 TVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYAS 211
+V L C + PP W +G +S V + + +VL+++ + D S
Sbjct: 620 SVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSV--------DGRVLRIEQAQLSDAGS 671
Query: 212 YTCQVSVRNVCGIPDKAITFRLT---NTTAPPALKLSVNETLVVNPGENVTVQCLLTGGD 268
Y C S NV G + R+ T PP+L V LV P V + C TG
Sbjct: 672 YRCVAS--NVAGSTELRYGLRVNVPPRITLPPSLPGPV---LVNTP---VRLTCNATGA- 722
Query: 269 PLPQLQWSHGPGPLP------LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTV 322
P P L W P+ L G L++ S +A DSG Y+C A + VG + V
Sbjct: 723 PSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 782
Query: 323 NLLVRSMKNATFQITPDVIKESENIQL--GQDLKLSCHVDAVPQEKVTYQWFKNGKPARM 380
+ P ++ E N+ + + + L C A+P ++ W+K+G+P
Sbjct: 783 ---------LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS--WWKDGRP--- 828
Query: 381 SKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPP 440
L R L A + L++ D G Y C A A + +N+ V P
Sbjct: 829 ----LEPRPGVHLSADKALLQVDRADVWDAGHYTCEA-LNQAGHSEKHYNLNVWVAPVFP 883
Query: 441 TISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLR 500
+ +TVREG P L CE RG P P + W + + +GL L
Sbjct: 884 L----RESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLY 939
Query: 501 LERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV----EPSSQDVRQALGRPV 556
L + GTY C+ + G + +QL V PP++ EP +Q V
Sbjct: 940 LGQAQLAQEGTYTCECSNVVGNS----SQDLQLEVHVPPQIAGPREPPTQ-VSVVQDGVA 994
Query: 557 LLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAE-----APDHAELRLDAVTRDSSG 611
L C+ P + W GQ P AE L ++ +G
Sbjct: 995 TLECNATGKPPPTV---TWERDGQ--------PVGAELGLQLQNQGQSLHVERAQAAHTG 1043
Query: 612 SYECSVSNDVGSAACLFQVS 631
Y C N G A F++S
Sbjct: 1044 RYSCVAENLAGRAERKFELS 1063
Score = 104 bits (259), Expect = 4e-22
Identities = 158/611 (25%), Positives = 225/611 (36%), Gaps = 90/611 (14%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTA----------------GSASDKFQETSVFNETLRIE 96
G +L L+C G P P++ W K A G ++L
Sbjct: 33 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFP 92
Query: 97 RIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLR 156
RI G Y C+AEN G A + + V L P + +V G V L+
Sbjct: 93 RIQEGDSGLYSCRAENQAGT-AQRDFHLLV--LTPPSVLGAGAAQEVLG--LAGADVELQ 147
Query: 157 CTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQV 216
C + P + W + + + L Q + +VL++ D Y C
Sbjct: 148 CWTSGVPTPQVEWTKDRQPVLPGGPH-------LQVQEDGQVLRITGSHVGDEGRYQCVA 200
Query: 217 SVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTG-GDPLPQLQW 275
+A F+L APP + S NET V E+ VQ L G P P + W
Sbjct: 201 ----FSPAGQQARDFQL-RVHAPPTIWGS-NETGEVAVMEDHLVQLLCEARGVPTPNITW 254
Query: 276 SHGPGPLPLGA---LAQGGT-LSIPSVQARDSGYYNCTATNNVGNPAKKT-VNLLVR-SM 329
LP +GG L + Q+ D+G Y C A+N VG K T +++ V ++
Sbjct: 255 FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTI 314
Query: 330 KNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRN 389
+ A + P V+K G+ + L C P T W G P S N
Sbjct: 315 EGAGGR--PYVVKAVA----GRPVALECVARGHPSP--TLSWHHEGLPVAES-------N 359
Query: 390 DPELPAVTSSLELIDLHFSDYGTYLCMASFP-GAPVPDLSVEVNISSETVPPTISVPKGR 448
+ L S L L + G Y C+AS P G V SVEV VPP + V +G
Sbjct: 360 ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQ-----VPPQLLVAEGL 414
Query: 449 AVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEE-------TPDGKLRL 501
VT G P EL C+ G P P + W L +G P EE + L +
Sbjct: 415 GQVTTIVGQPLELPCQASGSPVPTIQW---------LQNGRPAEELAGVQVASQGTTLHI 465
Query: 502 ERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV--EPSSQ---DVRQALGRPV 556
+ V D SG + CQ N E +V ++ ++ P V P Q P
Sbjct: 466 DHVELDHSGLFACQAT--NEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPA 523
Query: 557 LLRCSLLRG---SPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSY 613
+ RG P+ W G L P +P A P L+++ V G Y
Sbjct: 524 ACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP--PPLQIEKVDLRDEGIY 581
Query: 614 ECSVSNDVGSA 624
C+ +N G +
Sbjct: 582 TCAATNLAGES 592
Score = 98.2 bits (243), Expect = 3e-20
Identities = 140/618 (22%), Positives = 232/618 (37%), Gaps = 74/618 (11%)
Query: 30 VHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDK-FQETSV 88
VH + + +E N+S + +++ L+C P P + W K + S
Sbjct: 785 VHMPPSILGEELNVS-----VVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSA 839
Query: 89 FNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFY 148
L+++R G Y C+A N G + K ++V L T++ G+
Sbjct: 840 DKALLQVDRADVWDAGHYTCEALNQAG-HSEKHYNLNVWVAPVFPLRESHTLTVREGH-- 896
Query: 149 QEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQD 208
L C P + W++ L + G+ + ++L L +
Sbjct: 897 ---PTRLSCECRGVPFPKISWRKDGQPLP-GEGAGLQ-----HVSAVGRLLYLGQAQLAQ 947
Query: 209 YASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGD 268
+YTC+ S NV G + + + + + VV G T++C TG
Sbjct: 948 EGTYTCECS--NVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGV-ATLECNATGKP 1004
Query: 269 PLPQLQWSHGPGP----LPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNL 324
P P + W P L L QG +L + QA +G Y+C A N G +K
Sbjct: 1005 P-PTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKF--- 1060
Query: 325 LVRSMKNATFQITPDVIKESENIQ-----LGQDLKLSCHVDAVPQEKVTYQWFKNGKPAR 379
+ + P++I + + + L L L C +P + +WF+ +P
Sbjct: 1061 ------ELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAI--RWFRGEEPVS 1112
Query: 380 MSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP-GAPVPDLSVEVNISSETV 438
+ D L A L++ D G Y C+AS G + SVEV V
Sbjct: 1113 PGE-------DTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV-----LV 1160
Query: 439 PPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDG- 497
PP+I V+ V +G A L C V G P+P + W K+ L G +PDG
Sbjct: 1161 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWF---KDGRPLARGDAHHISPDGV 1217
Query: 498 KLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV-----EPSSQDVRQAL 552
L++ + + +G Y C A G + QL+V P + + + ++V +
Sbjct: 1218 LLQVLQANLSSAGHYSCIAANAVG----EKTKHFQLSVLLAPTILGGAEDSADEEVTVTV 1273
Query: 553 GRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGS 612
P+ L C L I W G P P L++ ++ +G
Sbjct: 1274 NNPISLICEALAFPSPNI---TWMKDG---APFEASRNIQLLPGTHGLQILNAQKEDAGQ 1327
Query: 613 YECSVSNDVGSAACLFQV 630
Y C V+N++G A + V
Sbjct: 1328 YTCVVTNELGEAVKNYHV 1345
Score = 95.1 bits (235), Expect = 3e-19
Identities = 145/598 (24%), Positives = 224/598 (37%), Gaps = 79/598 (13%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAG--SASDKFQETSVFNETLRIERIARTQGGRYY 107
+ E + L C G P P + W K S K T L++ R + G Y
Sbjct: 232 VMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTR-GGRQLQLGRAQSSDAGVYT 290
Query: 108 CKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKT-----VFLRCTVNSN 162
CKA N VG A K+ R+DV V T+ G Y K V L C +
Sbjct: 291 CKASNAVGA-AEKATRLDVY--------VPPTIEGAGGRPYVVKAVAGRPVALECVARGH 341
Query: 163 PPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVC 222
P W ++ S ++ ++ T G VL+L++ Y+C S
Sbjct: 342 PSPTLSWHHEGLPVAESNESRLE------TDG--SVLRLESPGEASSGLYSCVAS----- 388
Query: 223 GIPDKAITFRLTNTTAPPALKLSVNETLVVN-PGENVTVQCLLTGGDPLPQLQWSHGPGP 281
+A+ PP L ++ V G+ + + C G P+P +QW P
Sbjct: 389 SPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPC-QASGSPVPTIQWLQNGRP 447
Query: 282 LP----LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQIT 337
+ +QG TL I V+ SG + C ATN G A V + V +
Sbjct: 448 AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGT-AGAEVEVSVHG------EWA 500
Query: 338 PDVIKESENIQLGQDLKLSCHVDAVP---QEKVTYQWFKNGKPARM------SKRLLVTR 388
P V++ + +GQ H + P V W + KP +
Sbjct: 501 PGVLE----VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPT 556
Query: 389 NDPELPAVTSSLELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISV-PK 446
P ++ L++ + D G Y C A + G +++++V VPP I P
Sbjct: 557 GIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKV-----LVPPNIEPGPV 611
Query: 447 GRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGK-LRLERVS 505
+AV+ E + L+C G P P V W + + + S + + + DG+ LR+E+
Sbjct: 612 NKAVL---ENASVTLECLASGVPPPDVSWFKGHQPVS---SWMGVTVSVDGRVLRIEQAQ 665
Query: 506 RDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVE-PSSQDVRQALGRPVLLRCSLLR 564
+G+YRC + G E + L V PP + P S + PV L C+
Sbjct: 666 LSDAGSYRCVASNVAG----STELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCN-AT 720
Query: 565 GSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVG 622
G+P + +W G + P P P L L + SG Y C + VG
Sbjct: 721 GAPS--PTLMWLKDGNPVSPAG-TPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG 775
Score = 92.8 bits (229), Expect = 1e-18
Identities = 137/586 (23%), Positives = 215/586 (36%), Gaps = 88/586 (15%)
Query: 57 MLQCLVTGHPRPQVRWTKTAGSASDKFQETS---VFNETLRIERIARTQGGRYYCKAENG 113
+L C +G P+P V W K + Q+ + + + L + ++ C N
Sbjct: 2500 LLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNE 2559
Query: 114 VGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFY--QEKTVFLRCTVNSNPPARFIWKR 171
VG + L + + V T++D + +F V L C P W +
Sbjct: 2560 VG---------EAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSK 2610
Query: 172 GSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAI-- 229
L ++ +G Y + L++ P YTC S RN G+ K +
Sbjct: 2611 AGAQLG-ARGSG-------YRVSPSGALEIGQALPIHAGRYTC--SARNSAGVAHKHVFL 2660
Query: 230 TFRLTNTTAP-PALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALA 288
T + + P P++ +V E V+ P E G P P + W + G
Sbjct: 2661 TVQASPVVKPLPSVVRAVAEEEVLLPCE--------ASGIPRPTITWQKEGLNVATGVST 2712
Query: 289 Q---GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESE 345
Q GG L I D+G Y C A N+ G+ KT Q+ P +
Sbjct: 2713 QVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKT---------RLVVQVPPVIENGLP 2763
Query: 346 NIQL--GQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELI 403
++ G L C P+ +T W K+G+P ++ + EL
Sbjct: 2764 DLSTTEGSHAFLPCKARGSPEPNIT--WDKDGQPVSGAEGKFTIQPSGELLVK------- 2814
Query: 404 DLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQC 463
+L D GTY C A V V+++ +P ++P R++ R G L+C
Sbjct: 2815 NLEGQDAGTYTCTAE---NAVGRARRRVHLTILVLPVFTTLPGDRSL---RLGDRLWLRC 2868
Query: 464 EVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFN 523
RG P P + W+ D+ S E+ L+ VSR+ SGTY C G
Sbjct: 2869 AARGSPTPRIGWTVNDRPVTEGVS----EQDGGSTLQRAAVSREDSGTYVCWAENRVGRT 2924
Query: 524 -----VRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFK 578
V +EA V F VEP +G + L C ++RG P + W
Sbjct: 2925 QAVSFVHVKEAPVLQGEAFSYLVEP--------VGGSIQLDC-VVRGDP--VPDIHWIKD 2973
Query: 579 GQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSA 624
G L + + L + RD +G Y+C N++G A
Sbjct: 2974 GLPLRGSHL----RHQLQNGSLTIRRTERDDAGRYQCLAENEMGVA 3015
Score = 92.0 bits (227), Expect = 2e-18
Identities = 146/628 (23%), Positives = 223/628 (35%), Gaps = 86/628 (13%)
Query: 40 EDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGS-ASDKFQETSVFNETLRIERI 98
E+ E V + +G T L C VTGHP+P++ W K A S L++ +
Sbjct: 1165 ENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQA 1224
Query: 99 ARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCT 158
+ G Y C A N VG K ++ V L +L + +D + L C
Sbjct: 1225 NLSSAGHYSCIAANAVG-EKTKHFQLSV-LLAPTILGGAEDSADEEVTVTVNNPISLICE 1282
Query: 159 VNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSV 218
+ P W + S++ + T L++ N + +D YTC V+
Sbjct: 1283 ALAFPSPNITWMKDGAPFEASRN--------IQLLPGTHGLQILNAQKEDAGQYTCVVT- 1333
Query: 219 RNVCGIPDKAITFRLTNTTAPPAL-------KLSVNETLVVNPGENVTVQCLLTGGDPLP 271
N G +A+ PP++ ++ V E + +T++C + P P
Sbjct: 1334 -NELG---EAVKNYHVEVLIPPSISKDDPLAEVGVKE-VKTKVNSTLTLEC-ESWAVPPP 1387
Query: 272 QLQWSHGPGPLP----LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVR 327
++W P+ L L +G L I Q DSG Y C ATN G + N+L++
Sbjct: 1388 TIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGED-DQDFNVLIQ 1446
Query: 328 ----SMKNATFQITPDVIKESENIQLG----------QDLKLSCHVDAVPQEKVTYQWFK 373
K F +++ E + G L C +A+P +T W++
Sbjct: 1447 VPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLT--WYR 1504
Query: 374 NGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNI 433
+P + V + L++ + + G Y C AS L E+ +
Sbjct: 1505 EDQPLSAGDEVSVLQGG-------RVLQIPLVRAENAGRYSCKAS-NEVGEDWLHYELLV 1556
Query: 434 SSETVPPTISVPKGRAV--VTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPL 491
PP I V VTV S LQC G P P + W L +GLP
Sbjct: 1557 ---LTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW---------LQNGLPF 1604
Query: 492 EETP------DGK-LRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEP- 543
+P DG+ L++ + +Y C G E L VQ PP +
Sbjct: 1605 SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG----SAEKLFTLRVQVPPRIAGL 1660
Query: 544 SSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLD 603
+ V L V L C + P W Q L + P L+L
Sbjct: 1661 DLEQVTAILNSSVSLPCD-VHAHPN--PEVTWYKDSQAL---SLGEEVFLLPGTHTLQLG 1714
Query: 604 AVTRDSSGSYECSVSNDVGSAACLFQVS 631
SG Y C N G L Q+S
Sbjct: 1715 RARLSDSGMYTCEALNAAGRDQKLVQLS 1742
Score = 73.9 bits (180), Expect = 6e-13
Identities = 72/285 (25%), Positives = 116/285 (40%), Gaps = 33/285 (11%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYC 108
++R GD L L+C G P P++ WT ++ E TL+ ++R G Y C
Sbjct: 2857 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDG-GSTLQRAAVSREDSGTYVC 2915
Query: 109 KAENGVGVPAIKSIRVDVQYLDEPML---TVHQTVSDVRGNFYQEKTVFLRCTVNSNPPA 165
AEN VG S V + P+L V V G+ + L C V +P
Sbjct: 2916 WAENRVGRTQAVSF---VHVKEAPVLQGEAFSYLVEPVGGS------IQLDCVVRGDPVP 2966
Query: 166 RFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIP 225
W + L S L Q + L ++ D Y C N G+
Sbjct: 2967 DIHWIKDGLPLRGSH---------LRHQLQNGSLTIRRTERDDAGRYQCLAE--NEMGVA 3015
Query: 226 DKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG 285
K + L + P ++ + + V G++V ++C TG +P P ++W PL
Sbjct: 3016 KKVVILVLQSA---PVFQVEPQD-MTVRSGDDVALRCQATG-EPTPTIEWLQAGQPLRAS 3070
Query: 286 ALAQ---GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVR 327
+ G+L + +V+ D+G Y+C A N +G+ + L+VR
Sbjct: 3071 RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAF-LVVR 3114
Score = 55.1 bits (131), Expect = 3e-07
Identities = 44/151 (29%), Positives = 62/151 (41%), Gaps = 9/151 (5%)
Query: 30 VHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF 89
VH +A V++ + S V + G ++ L C+V G P P + W K +
Sbjct: 2930 VHVKEAPVLQGEAFSYLVEPV--GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQ 2987
Query: 90 NETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQ 149
N +L I R R GRY C AEN +GV A K + + +Q P+ V VR
Sbjct: 2988 NGSLTIRRTERDDAGRYQCLAENEMGV-AKKVVILVLQ--SAPVFQVEPQDMTVRSG--- 3041
Query: 150 EKTVFLRCTVNSNPPARFIWKRGSDTLSHSQ 180
V LRC P W + L S+
Sbjct: 3042 -DDVALRCQATGEPTPTIEWLQAGQPLRASR 3071
Score = 41.6 bits (96), Expect = 0.004
Identities = 24/111 (21%), Positives = 48/111 (43%), Gaps = 2/111 (1%)
Query: 14 FHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWT 73
+ C + A+ ++ Q+ V + + + T+R GD + L+C TG P P + W
Sbjct: 3004 YQCLAENEMGVAKKVVILVLQSAPVFQ--VEPQDMTVRSGDDVALRCQATGEPTPTIEWL 3061
Query: 74 KTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRV 124
+ + ++ + +L +E + G Y C A N +G ++ V
Sbjct: 3062 QAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLV 3112
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 137 bits (345), Expect = 5e-32
Identities = 154/581 (26%), Positives = 231/581 (39%), Gaps = 61/581 (10%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTKT-AGSASDKFQETSVFNETLRIERIARTQGGRYY 107
T+ G+T +L C V G + W + + + + + +L I I T GGRY
Sbjct: 410 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 469
Query: 108 CKAENGVGVPAIKSIRVDVQYL--DEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPA 165
C A N GV R V L + P +++H + +F Q V + C+ + P
Sbjct: 470 CVASNANGV-----TRASVWLLVREAPQVSIHTSSQ----HFSQGVEVKVSCSASGYPTP 520
Query: 166 RFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIP 225
W R S L VD L QG + P+D +Y+CQ + N G
Sbjct: 521 HISWSRESQALQEDSRIHVDAQGTLIIQG---------VAPEDAGNYSCQAT--NEVGTD 569
Query: 226 DKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG 285
+ +T T+ PP++ +VN ++V GE + C +G P P++ W G + L
Sbjct: 570 QETVTLYYTD---PPSVS-AVNAVVLVAVGEEAVLVCEASGVPP-PRVIWYRGGLEMILA 624
Query: 286 AL-AQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKES 344
+ G L IP+ Q RD+G Y C A N +G+ A + L V T ++ DV
Sbjct: 625 PEGSSSGKLRIPAAQERDAGTYTCRAVNELGD-ASAEIQLAVGHAPQLT-ELPRDV---- 678
Query: 345 ENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELID 404
++LG+ L+C P VT+ + G + RL R + L
Sbjct: 679 -TVELGRSALLACRATGRPPPTVTW---RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFES 734
Query: 405 LHFSDYGTYLCMASFPGAPVPDLSVEVN-ISSETVPPTISVPKGRAVVTVREGSPAELQC 463
+ D Y+C A V E I + PP I+ V V EG P L C
Sbjct: 735 VAPEDQAPYVCEARNVFGKV---QAEARLIVTGHAPPQIA--SSAPTVRVLEGQPVSLPC 789
Query: 464 EV-RGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGF 522
V G+P P W K+ LP G DG L L+R ++ +G Y C G
Sbjct: 790 IVLAGRPLPERHWL---KDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGS 846
Query: 523 NVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW-RFKGQL 581
R V+L VQ PP + P++ G P L C + G P + W + L
Sbjct: 847 QHR----DVELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVP--APTITWTKETNAL 899
Query: 582 LPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVG 622
P + E L + + +G+Y C+ +N VG
Sbjct: 900 TSRGPHYNVSKE----GTLLIAQPSAQDAGAYVCTATNTVG 936
Score = 127 bits (319), Expect = 5e-29
Identities = 155/598 (25%), Positives = 237/598 (39%), Gaps = 88/598 (14%)
Query: 52 EGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAE 111
+G + + C +G+P P + W++ + + + + TL I+ +A G Y C+A
Sbjct: 504 QGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQAT 563
Query: 112 NGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKR 171
N VG V + Y D P ++ V V + L C + PP R IW R
Sbjct: 564 NEVGTD---QETVTLYYTDPPSVSAVNAVVLVAVG----EEAVLVCEASGVPPPRVIWYR 616
Query: 172 GSDTLSHSQDNGVDIYEPLYTQGETK-VLKLKNLRPQDYASYTCQVSVRNVCGIPDKAIT 230
G G+++ L +G + L++ + +D +YTC R V + D +
Sbjct: 617 G----------GLEMI--LAPEGSSSGKLRIPAAQERDAGTYTC----RAVNELGDASAE 660
Query: 231 FRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGP---LPLGA- 286
+L AP +L + T V G + + C TG P P + W G G L LGA
Sbjct: 661 IQLAVGHAPQLTELPRDVT--VELGRSALLACRATGRPP-PTVTWRRGDGQPLGLRLGAG 717
Query: 287 ------LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDV 340
G L SV D Y C A N G + L+V T P +
Sbjct: 718 RGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGK-VQAEARLIV------TGHAPPQI 770
Query: 341 IKESENIQL--GQDLKLSCHVDA---VPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPA 395
+ +++ GQ + L C V A +P+ W K+G+P R + +
Sbjct: 771 ASSAPTVRVLEGQPVSLPCIVLAGRPLPER----HWLKDGRPLPPGSRHSIRAD------ 820
Query: 396 VTSSLELIDLHFSDYGTYLCMAS-FPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVR 454
SL L G Y C+A+ G+ D+ + V VPP I P +T
Sbjct: 821 --GSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ-----VPPRIH-PTATHHIT-N 871
Query: 455 EGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRC 514
EG PA L C G P P + W++ + AL G + +G L + + S +G Y C
Sbjct: 872 EGVPASLPCVASGVPAPTITWTK--ETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVC 929
Query: 515 QTARYNGFNVRPREAQVQLNVQFPPEVEPSSQ-------DVRQALGRPVLLRCSLLRGSP 567
GF+ + +++L+V P + + V G V L C +GSP
Sbjct: 930 TATNTVGFSSQ----EMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEA-KGSP 984
Query: 568 QRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAA 625
+ + W + P PP+ P LRL V SG YEC+ SN GSA+
Sbjct: 985 PPLVT--WTKDSR--PVPPITNRYGLLPS-GSLRLAQVQVGDSGHYECTASNPAGSAS 1037
Score = 121 bits (304), Expect = 3e-27
Identities = 143/552 (25%), Positives = 214/552 (38%), Gaps = 72/552 (13%)
Query: 83 FQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSD 142
FQE+ N + I R ++ + G Y C A + G K+ V + + + TVS
Sbjct: 356 FQESG--NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSP 413
Query: 143 VRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLK 202
+T L C V P W R L S + + L++
Sbjct: 414 -------GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD--------LSLEIS 458
Query: 203 NLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQC 262
+ P D Y C S N G+ +A + L ++ S + G V V C
Sbjct: 459 GIIPTDGGRYQCVAS--NANGVT-RASVWLLVREAPQVSIHTSSQH---FSQGVEVKVSC 512
Query: 263 LLTGGDPLPQLQWSHGPGPLPLGA---LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAK 319
+G P P + WS L + + GTL I V D+G Y+C ATN VG +
Sbjct: 513 SASGY-PTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD-Q 570
Query: 320 KTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPAR 379
+TV L + + + + +G++ L C VP +V W++ G
Sbjct: 571 ETVTLYYTDPPSVS------AVNAVVLVAVGEEAVLVCEASGVPPPRVI--WYRGGLEMI 622
Query: 380 MSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVP 439
++ PE + + L + D GTY C A + D S E+ ++ P
Sbjct: 623 LA---------PE-GSSSGKLRIPAAQERDAGTYTCRAV---NELGDASAEIQLAVGHAP 669
Query: 440 PTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPL-------E 492
+P+ VTV G A L C G+P P V W R D + P GL L
Sbjct: 670 QLTELPRD---VTVELGRSALLACRATGRPPPTVTWRRGDGQ----PLGLRLGAGRGSRS 722
Query: 493 ETPD-GKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQA 551
PD G L E V+ + Y C+ N F EA++ + PP++ S+ VR
Sbjct: 723 RQPDSGVLFFESVAPEDQAPYVCEAR--NVFGKVQAEARLIVTGHAPPQIASSAPTVRVL 780
Query: 552 LGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSG 611
G+PV L C +L G P + W G+ LPP A+ L LD ++ +G
Sbjct: 781 EGQPVSLPCIVLAGRP--LPERHWLKDGRPLPPGSRHSIRAD----GSLHLDRALQEHAG 834
Query: 612 SYECSVSNDVGS 623
Y C +N GS
Sbjct: 835 RYSCVATNTAGS 846
Score = 119 bits (297), Expect = 2e-26
Identities = 149/568 (26%), Positives = 221/568 (38%), Gaps = 80/568 (14%)
Query: 47 VYTIREGDTLMLQCLVTGHPRPQVRWTKTA--------GSASDKFQETSVFNETLRIERI 98
V + G+ +L C +G P P+V W + GS+S K LRI
Sbjct: 589 VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK----------LRIPAA 638
Query: 99 ARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCT 158
G Y C+A N +G A I++ V + P LT + DV ++ L C
Sbjct: 639 QERDAGTYTCRAVNELG-DASAEIQLAVGHA--PQLT--ELPRDVTVEL--GRSALLACR 691
Query: 159 VNSNPPARFIWKRGSDT---LSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQ 215
PP W+RG L G +P ++ VL +++ P+D A Y C+
Sbjct: 692 ATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQP-----DSGVLFFESVAPEDQAPYVCE 746
Query: 216 VSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQW 275
RNV G +T APP + S T+ V G+ V++ C++ G PLP+ W
Sbjct: 747 A--RNVFGKVQAEARLIVTGH-APPQIASSA-PTVRVLEGQPVSLPCIVLAGRPLPERHW 802
Query: 276 SHGPGPLPLGA---LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLV----RS 328
PLP G+ + G+L + +G Y+C ATN G+ + V L+V R
Sbjct: 803 LKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQ-HRDVELVVQVPPRI 861
Query: 329 MKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTR 388
AT IT + + S L C VP +T+ N +R V++
Sbjct: 862 HPTATHHITNEGVPAS----------LPCVASGVPAPTITWTKETNALTSR-GPHYNVSK 910
Query: 389 NDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGR 448
L A S+ D G Y+C A+ V S E+ +S T P I + R
Sbjct: 911 EGTLLIAQPSA--------QDAGAYVCTAT---NTVGFSSQEMRLSVNT-KPRIHMNGSR 958
Query: 449 AV-----VTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLER 503
VT + G L CE +G P P V W++ + + + L P G LRL +
Sbjct: 959 NANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGL--LPSGSLRLAQ 1016
Query: 504 VSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLL 563
V SG Y C + G VQ + P+ P G L LL
Sbjct: 1017 VQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSG----LSVPLL 1072
Query: 564 RGSPQRIASAVWRFKGQLLPPPPVVPAA 591
+ +P+ + + LPPP P +
Sbjct: 1073 QPTPRSVRLCHLSLRAP-LPPPFATPTS 1099
Score = 114 bits (285), Expect = 4e-25
Identities = 133/507 (26%), Positives = 195/507 (38%), Gaps = 78/507 (15%)
Query: 148 YQEKTVFLRCTVNSNPPARFIWKRGSDTLS---HSQDNGVDIYEPLYTQGETKVLKLKNL 204
Y + + + C+V+S P R +RG L H Q++G +E L
Sbjct: 322 YLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRAS----------- 370
Query: 205 RPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLL 264
+ +Y C R G I T PP L + N T V+PGE + C +
Sbjct: 371 -KAEEGTYECTAVSRAGTGRAKAQIVV----TDPPPQLVPAPNVT--VSPGETAVLSCRV 423
Query: 265 TGGDPLPQLQWSHGPGPLPL--GALAQGGTLS--IPSVQARDSGYYNCTATNNVGNPAKK 320
G P L W LP G +AQ LS I + D G Y C A+N G +
Sbjct: 424 LGEAPY-NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG-VTRA 481
Query: 321 TVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARM 380
+V LLVR + + S++ G ++K+SC P ++ W + + +
Sbjct: 482 SVWLLVREAPQVSIHTS------SQHFSQGVEVKVSCSASGYPTPHIS--WSRESQALQE 533
Query: 381 SKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETV-- 438
R+ V +L + + D G Y C A+ EV ETV
Sbjct: 534 DSRIHVDAQ--------GTLIIQGVAPEDAGNYSCQATN----------EVGTDQETVTL 575
Query: 439 ----PPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEET 494
PP++S AVV V G A L CE G P P V+W R E L P G +
Sbjct: 576 YYTDPPSVSAVN--AVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG-----S 628
Query: 495 PDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGR 554
GKLR+ +GTY C+ G A++QL V P++ +DV LGR
Sbjct: 629 SSGKLRIPAAQERDAGTYTCRAVNELG----DASAEIQLAVGHAPQLTELPRDVTVELGR 684
Query: 555 PVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAA----AEAPDHAELRLDAVTRDSS 610
LL C R + + + WR +G P + A + PD L ++V +
Sbjct: 685 SALLAC---RATGRPPPTVTWR-RGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQ 740
Query: 611 GSYECSVSNDVGSAACLFQVSAKAYSP 637
Y C N G ++ ++P
Sbjct: 741 APYVCEARNVFGKVQAEARLIVTGHAP 767
Score = 83.6 bits (205), Expect = 8e-16
Identities = 80/324 (24%), Positives = 130/324 (40%), Gaps = 38/324 (11%)
Query: 13 PFHCRGQGVYAPAQAQ--IVHAGQACVVKEDNISERVYTIR--EGDTLMLQCLV-TGHPR 67
P+ C + V+ QA+ ++ G A I+ T+R EG + L C+V G P
Sbjct: 742 PYVCEARNVFGKVQAEARLIVTGHA----PPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 797
Query: 68 PQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQ 127
P+ W K + + + +L ++R + GRY C A N G S DV+
Sbjct: 798 PERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG-----SQHRDVE 852
Query: 128 YLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIY 187
+ + +H T + N + L C + P W + ++ L+
Sbjct: 853 LVVQVPPRIHPTATHHITN--EGVPASLPCVASGVPAPTITWTKETNALTSRG------- 903
Query: 188 EPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPP-----AL 242
P Y + L + QD +Y C + N G + + RL+ T P +
Sbjct: 904 -PHYNVSKEGTLLIAQPSAQDAGAYVCTAT--NTVGFSSQEM--RLSVNTKPRIHMNGSR 958
Query: 243 KLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP----LGALAQGGTLSIPSV 298
+V + GE VT+ C G P P + W+ P+P L G+L + V
Sbjct: 959 NANVPLQVTAKAGEEVTLDCEAKGSPP-PLVTWTKDSRPVPPITNRYGLLPSGSLRLAQV 1017
Query: 299 QARDSGYYNCTATNNVGNPAKKTV 322
Q DSG+Y CTA+N G+ + + V
Sbjct: 1018 QVGDSGHYECTASNPAGSASHRYV 1041
Score = 68.2 bits (165), Expect = 4e-11
Identities = 97/424 (22%), Positives = 156/424 (36%), Gaps = 54/424 (12%)
Query: 14 FHCRGQGVYAPAQAQIVHAGQACVVKEDNISE--RVYTIREGDTLMLQCLVTGHPRPQVR 71
+ CR A A+I Q V ++E R T+ G + +L C TG P P V
Sbjct: 646 YTCRAVNELGDASAEI----QLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVT 701
Query: 72 WTKTAG-------SASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRV 124
W + G A + + L E +A Y C+A N G ++ +
Sbjct: 702 WRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLI 761
Query: 125 DVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPP-ARFIWKRGSDTLSHSQDNG 183
+ + + TV + G + V L C V + P W + L +
Sbjct: 762 VTGHAPPQIASSAPTVRVLEG-----QPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHS 816
Query: 184 VDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALK 243
+ L+ L + Y+C + N G + + + PP +
Sbjct: 817 IRADGSLH---------LDRALQEHAGRYSCVAT--NTAGSQHRDVELVV---QVPPRIH 862
Query: 244 LSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPL----PLGALAQGGTLSIPSVQ 299
+ + N G ++ C + G P P + W+ L P +++ GTL I
Sbjct: 863 PTATHH-ITNEGVPASLPC-VASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPS 920
Query: 300 ARDSGYYNCTATNNVGNPAKK---TVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLS 356
A+D+G Y CTATN VG +++ +VN R N + + + G+++ L
Sbjct: 921 AQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNAN---VPLQVTAKAGEEVTLD 977
Query: 357 CHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCM 416
C P VT W K+ +P +T LP + SL L + D G Y C
Sbjct: 978 CEAKGSPPPLVT--WTKDSRPVPP-----ITNRYGLLP--SGSLRLAQVQVGDSGHYECT 1028
Query: 417 ASFP 420
AS P
Sbjct: 1029 ASNP 1032
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 134 bits (336), Expect = 5e-31
Identities = 144/549 (26%), Positives = 224/549 (40%), Gaps = 68/549 (12%)
Query: 52 EGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQET--SVFNETLRIERIARTQ-GGRYYC 108
E + L C V G+P+P +RW K G+ D + SV +L I +TQ G Y C
Sbjct: 42 EEKKVKLNCEVKGNPKPHIRW-KLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQC 100
Query: 109 KAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFI 168
A N G + ++ YLD TVS RG + + L C PP
Sbjct: 101 TATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRG-----QGMVLLC----GPPPH-- 149
Query: 169 WKRGSDTLSHSQD-NGVDIYEP--LYTQGETKVLKLKNLRPQDYASYTCQVS--VRN--V 221
S LS++ N Y+ + ET L + + D +YTC V+ V N V
Sbjct: 150 ----SGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKV 205
Query: 222 CGIPDKAITFRLTNTTA----PPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSH 277
G P I L N P +++ ET+ G V ++C G +P+P + W
Sbjct: 206 LGPPTPLI---LRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALG-NPVPTIIWRR 261
Query: 278 GPGPLPLGALAQ----GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNAT 333
G P+ A+ G L IP+ Q D+G Y C A N+ G + T
Sbjct: 262 ADGK-PIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARG---------QLT 311
Query: 334 FQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPEL 393
F P+ I++ +I + + + A + K TY+W KNG+P L+TR+ ++
Sbjct: 312 FYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEP-------LLTRDRIQI 364
Query: 394 PAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTV 453
T ++ +++L SD G Y C+A + +S V P S + V V
Sbjct: 365 EQGTLNITIVNL--SDAGMYQCLAENKHGVI---FSNAELSVIAVGPDFSRTLLKRVTLV 419
Query: 454 REGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYR 513
+ G ++C+ + P+P W K +L + + DG LR+ V++ +G+Y
Sbjct: 420 KVGGEVVIECKPKASPKPVYTWK---KGRDILKENERITISEDGNLRIINVTKSDAGSYT 476
Query: 514 CQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASA 573
C N F + + V PSS DV +G ++L C + I
Sbjct: 477 CIAT--NHFGTASSTGNLVVKDPTRVMVPPSSMDV--TVGESIVLPCQVTHDHSLDIV-F 531
Query: 574 VWRFKGQLL 582
W F G L+
Sbjct: 532 TWSFNGHLI 540
Score = 83.6 bits (205), Expect = 8e-16
Identities = 87/385 (22%), Positives = 145/385 (37%), Gaps = 42/385 (10%)
Query: 267 GDPLPQLQWSHGPGPLPLG-----ALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKT 321
G+P P ++W + G ++ +G L + +D+G Y CTATN+ G +
Sbjct: 54 GNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSRE 113
Query: 322 VNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMS 381
L + N + V +++ GQ + L C E ++Y W N P+
Sbjct: 114 AKLQFAYLDNFKTRTRSTV-----SVRRGQGMVLLCGPPPHSGE-LSYAWIFNEYPSYQD 167
Query: 382 KRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP-------GAPVPDLSVEVNIS 434
R V++ T +L + + SD G Y C+ + G P P + +
Sbjct: 168 NRRFVSQE-------TGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVM 220
Query: 435 SETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEET 494
E P I V V T + G+ +L+C G P P ++W R D + +
Sbjct: 221 GE-YEPKIEVQFPETVPTAK-GATVKLECFALGNPVPTIIWRRADGKPIARKAR---RHK 275
Query: 495 PDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGR 554
+G L + ++ +G Y C G NV A+ QL P D+ A+
Sbjct: 276 SNGILEIPNFQQEDAGLYECVAENSRGKNV----ARGQLTFYAQPNWIQKINDIHVAMEE 331
Query: 555 PVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYE 614
V C G P+ + W G+ P++ + L + V +G Y+
Sbjct: 332 NVFWECKA-NGRPK--PTYKWLKNGE-----PLLTRDRIQIEQGTLNITIVNLSDAGMYQ 383
Query: 615 CSVSNDVGSAACLFQVSAKAYSPEF 639
C N G ++S A P+F
Sbjct: 384 CLAENKHGVIFSNAELSVIAVGPDF 408
Score = 52.0 bits (123), Expect = 3e-06
Identities = 107/493 (21%), Positives = 178/493 (36%), Gaps = 63/493 (12%)
Query: 149 QEKTVFLRCTVNSNPPARFIWK-RGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQ 207
+EK V L C V NP WK G+D D G+D Y+ E +L + Q
Sbjct: 42 EEKKVKLNCEVKGNPKPHIRWKLNGTDV-----DTGMDFR---YSVVEGSLLINNPNKTQ 93
Query: 208 DYASYTCQV--SVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLT 265
D +Y C S + K L N K T+ V G+ + + C
Sbjct: 94 DAGTYQCTATNSFGTIVSREAKLQFAYLDN------FKTRTRSTVSVRRGQGMVLLCGPP 147
Query: 266 GGDPLPQLQWSHGPGPLPLG----ALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAK-- 319
W P + G L I V+ D G Y C TN V N
Sbjct: 148 PHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLG 207
Query: 320 KTVNLLVRSMKNATFQITPDV---IKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGK 376
L++R+ + P + E+ G +KL C P + ++ +GK
Sbjct: 208 PPTPLILRN-DGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRR-ADGK 265
Query: 377 P-ARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNIS 434
P AR ++R LE+ + D G Y C+A + G V +
Sbjct: 266 PIARKARR----------HKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQ 315
Query: 435 SETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEET 494
+ + V + E +C+ G+P+P W + + E L + +E+
Sbjct: 316 PNWIQKINDIH-----VAMEEN--VFWECKANGRPKPTYKWLK-NGEPLLTRDRIQIEQ- 366
Query: 495 PDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPS--SQDVRQAL 552
G L + V+ +G Y+C +G E V + P+ + + +
Sbjct: 367 --GTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSV---IAVGPDFSRTLLKRVTLVKV 421
Query: 553 GRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGS 612
G V++ C + SP+ + + W+ +L + + + LR+ VT+ +GS
Sbjct: 422 GGEVVIECKP-KASPKPVYT--WKKGRDILKENERITISEDG----NLRIINVTKSDAGS 474
Query: 613 YECSVSNDVGSAA 625
Y C +N G+A+
Sbjct: 475 YTCIATNHFGTAS 487
Score = 43.9 bits (102), Expect = 7e-04
Identities = 45/209 (21%), Positives = 79/209 (37%), Gaps = 24/209 (11%)
Query: 45 ERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGG 104
+RV ++ G ++++C P+P W K + + T + LRI + ++ G
Sbjct: 414 KRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAG 473
Query: 105 RYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPP 164
Y C A N G S ++ D + V + DV +++ L C V +
Sbjct: 474 SYTCIATNHFGT---ASSTGNLVVKDPTRVMVPPSSMDVTVG----ESIVLPCQVTHDHS 526
Query: 165 AR--FIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVS----- 217
F W + +D D +E + Q L ++N++ + Y C V
Sbjct: 527 LDIVFTWSFNGHLIDFDRDG--DHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDR 584
Query: 218 --------VRNVCGIPDKAITFRLTNTTA 238
VR G P+ +T+TTA
Sbjct: 585 LSAAADLIVRGPPGPPEAVTIDEITDTTA 613
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 129 bits (324), Expect = 1e-29
Identities = 152/605 (25%), Positives = 244/605 (40%), Gaps = 73/605 (12%)
Query: 43 ISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSA-SDKFQETSVFNETLRIERIART 101
+S + I+ +TL L+C P + W K SD + TL+I+ +
Sbjct: 2679 LSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQIS 2738
Query: 102 QGGRYYCKAENGVGVPAIK-SIRVDVQYLDEPMLTVHQTVSDVRGNFYQE----KTVFLR 156
GRY C A N G + + + V + + + + R ++ + L
Sbjct: 2739 DTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLY 2798
Query: 157 CTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQV 216
C N+ PP W + L+ S + L G +VL++ + +D YTC V
Sbjct: 2799 CETNAAPPPTLTWYKDGHPLTSSD-------KVLILPGG-RVLQIPRAKVEDAGRYTC-V 2849
Query: 217 SVRNVCGIPDKAITFRLTNTTAPPALK-----LSVNETLVVNPGENVTVQCLLTGGDPLP 271
+V N G R+ PP +K L T++VN ++ ++CL + G P P
Sbjct: 2850 AV-NEAGEDSLQYDVRVL---VPPIIKGANSDLPEEVTVLVN--KSALIECL-SSGSPAP 2902
Query: 272 QLQWSHGPGPLPLGA----LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVR 327
+ W PL L+ G L I + Q D G Y C A N G+ AKK NL V
Sbjct: 2903 RNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGS-AKKYFNLNVH 2961
Query: 328 SMKNATFQITPDVI-KESENIQL--GQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRL 384
+ P VI +SEN+ + + L+C V P ++ W KN +P +++
Sbjct: 2962 --------VPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLS--WLKNEQPIKLNTNT 3011
Query: 385 LVTRNDPELPAVTSSLELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTIS 443
L+ +L++I SD G Y C+A + G S+ V VPP+I
Sbjct: 3012 LIVPGG-------RTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVY-----VPPSIK 3059
Query: 444 V--PKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGK-LR 500
+ +VV VREG+ L+CE P P + W K ++ +E DG+ L
Sbjct: 3060 DHDSESLSVVNVREGTSVSLECESNAVPPPVITWY---KNGRMITESTHVEILADGQMLH 3116
Query: 501 LERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVE-PSSQDVRQALGRPVLLR 559
+++ +G Y C+ G + + LNV PP +E P + + + + PV L
Sbjct: 3117 IKKAEVSDTGQYVCRAINVAGRD----DKNFHLNVYVPPSIEGPEREVIVETISNPVTLT 3172
Query: 560 CSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSN 619
C P IA W + + + ++L++ SG+Y C SN
Sbjct: 3173 CDATGIPPPTIA---WLKNHKRIENSDSLEVRI-LSGGSKLQIARSQHSDSGNYTCIASN 3228
Query: 620 DVGSA 624
G A
Sbjct: 3229 MEGKA 3233
Score = 126 bits (316), Expect = 1e-28
Identities = 153/595 (25%), Positives = 238/595 (40%), Gaps = 86/595 (14%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAEN 112
G + + C TG+P+P++ WT + + TL I+ A G Y C A N
Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASN 685
Query: 113 GVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRG 172
G S ++Y++ P L V Q+ V + TV + C + PP + W +G
Sbjct: 686 SAGTDKQNS---TLRYIEAPKLMVVQSELLVA---LGDITV-MECKTSGIPPPQVKWFKG 738
Query: 173 SDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFR 232
L S I +PL +LK++ + D YTC V++ N G T +
Sbjct: 739 DLELRPST---FLIIDPL-----LGLLKIQETQDLDAGDYTC-VAI-NEAG----RATGK 784
Query: 233 LTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPG------PLPLGA 286
+T P + + + + G NVT+ C + G P P ++W P + +
Sbjct: 785 ITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQ-GYPEPTIKWRRLDNMPIFSRPFSVSS 843
Query: 287 LAQ--GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKES 344
++Q G L I ++ A D G Y C A N G +T + V + I+P V
Sbjct: 844 ISQLRTGALFILNLWASDKGTYICEAENQFGKIQSET-TVTVTGLVAPLIGISPSV---- 898
Query: 345 ENIQLGQDLKLSCHV---DAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLE 401
N+ GQ L L C + + +P+ + W KN + + R+D SL
Sbjct: 899 ANVIEGQQLTLPCTLLAGNPIPERR----WIKN-SAMLLQNPYITVRSD-------GSLH 946
Query: 402 LIDLHFSDYGTYLCMAS-FPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAE 460
+ + D G Y C+AS G SV V+ V PTI G+ +++ EG P
Sbjct: 947 IERVQLQDGGEYTCVASNVAGTNNKTTSVVVH-----VLPTIQ--HGQQILSTIEGIPVT 999
Query: 461 LQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYN 520
L C+ G P+P V+WS+ K + S DG L + + SG Y C
Sbjct: 1000 LPCKASGNPKPSVIWSK--KGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTA 1057
Query: 521 GFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQ 580
G+ R +VQL V P V + + Q +PV S+L G + V
Sbjct: 1058 GYAKR----KVQLTVYVRPRVFGDQRGLSQ--DKPV--EISVLAGEEVTLPCEVKSL--- 1106
Query: 581 LLPPPPVVPAAAE-------APDH-----AELRLDAVTRDSSGSYECSVSNDVGS 623
PPP++ A E +P H +++ SG Y C +N G+
Sbjct: 1107 ---PPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGN 1158
Score = 123 bits (308), Expect = 9e-28
Identities = 146/600 (24%), Positives = 244/600 (40%), Gaps = 70/600 (11%)
Query: 45 ERVYTIREGDTLMLQCLVTGHPRPQVRWTKTA---GSASDKFQETSVFNETLRIERIART 101
+++ + EG + L C +G+P+P V W+K ++S KF + + +L +
Sbjct: 987 QQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGA--DGSLYVVSPGGE 1044
Query: 102 QGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSD---VRGNFYQEKTVFLRCT 158
+ G Y C A N G A + +++ V Y+ + + +S V + + V L C
Sbjct: 1045 ESGEYVCTATNTAGY-AKRKVQLTV-YVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCE 1102
Query: 159 VNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSV 218
V S PP W + + +S + P +T + +K+ R D Y C +
Sbjct: 1103 VKSLPPPIITWAKETQLISP--------FSPRHTFLPSGSMKITETRTSDSGMYLCVAT- 1153
Query: 219 RNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHG 278
N+ G +A+ N PP ++ L V G+ V + C G PLP + WS G
Sbjct: 1154 -NIAGNVTQAVKL---NVHVPPKIQRGPKH-LKVQVGQRVDIPCNAQG-TPLPVITWSKG 1207
Query: 279 PGPLPLGALAQ----GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATF 334
+ + GTLSI D+G Y C ATN G + + L V+
Sbjct: 1208 GSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETE-ITLHVQEPPTVE- 1265
Query: 335 QITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELP 394
+ P + Q ++ C P K T +W NG+ +T +P +
Sbjct: 1266 DLEPPYNTTFQERVANQRIEFPCPAKGTP--KPTIKWLHNGRE--------LTGREPGIS 1315
Query: 395 AVTSSLELIDLHFSDY--GTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISVPKGRAVV 451
+ L+ + Y G Y+C+A + G +++V+ VPP I + V
Sbjct: 1316 ILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVH-----VPPVIKDKEQVTNV 1370
Query: 452 TVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGK-LRLERVSRDMSG 510
+V L CEV G P P ++W K+ + ++ +GK L+L R + + +G
Sbjct: 1371 SVLLNQLTNLFCEVEGTPSPIIMWY---KDNVQVTESSTIQTVNNGKILKLFRATPEDAG 1427
Query: 511 TYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSS--QDVRQALGRPVLLRCSLLRGSPQ 568
Y C+ G + + ++V PP + ++ +V L R V L C + +G+P
Sbjct: 1428 RYSCKAINIAGTS----QKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQV-KGTP- 1481
Query: 569 RIASAVWRFKGQ--LLPPPPVVPAAAEAPDHAE-LRLDAVTRDSSGSYECSVSNDVGSAA 625
W G+ L P V E D + L L R+ G Y+C+VSN G A
Sbjct: 1482 -FPDIHWFKDGKPLFLGDPNV-----ELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQA 1535
Score = 122 bits (305), Expect = 2e-27
Identities = 147/582 (25%), Positives = 236/582 (40%), Gaps = 59/582 (10%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQ---GGRYYCK 109
GD +++C +G P PQV+W K G + + + L + +I TQ G Y C
Sbjct: 716 GDITVMECKTSGIPPPQVKWFK--GDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCV 773
Query: 110 AENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIW 169
A N G A I +DV P + + Q +DV + V L C V P W
Sbjct: 774 AINEAG-RATGKITLDV---GSPPVFI-QEPADV--SMEIGSNVTLPCYVQGYPEPTIKW 826
Query: 170 KRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAI 229
+R + S+ V L T L + NL D +Y C+ N G
Sbjct: 827 RRLDNMPIFSRPFSVSSISQL----RTGALFILNLWASDKGTYICE--AENQFGKIQSET 880
Query: 230 TFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPL---PLGA 286
T +T A P + +S + V+ G+ +T+ C L G+P+P+ +W L P
Sbjct: 881 TVTVTGLVA-PLIGISPSVANVIE-GQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYIT 938
Query: 287 LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESEN 346
+ G+L I VQ +D G Y C A +NV KT +++V + T Q ++ E
Sbjct: 939 VRSDGSLHIERVQLQDGGEYTCVA-SNVAGTNNKTTSVVVHVL--PTIQHGQQILSTIEG 995
Query: 347 IQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLH 406
I + L C P+ V W K G+ L+ T + SL ++
Sbjct: 996 I----PVTLPCKASGNPKPSVI--WSKKGE-------LISTSSAKFSAGADGSLYVVSPG 1042
Query: 407 FSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISVPKGRAV-VTVREGSPAELQCE 464
+ G Y+C A + G + + V + + + + V ++V G L CE
Sbjct: 1043 GEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCE 1102
Query: 465 VRGKPRPPVLWSRVDKEAALLPSGLPLEE-TPDGKLRLERVSRDMSGTYRCQTARYNGFN 523
V+ P P + W+ KE L+ P P G +++ SG Y C G N
Sbjct: 1103 VKSLPPPIITWA---KETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAG-N 1158
Query: 524 VRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLP 583
V V+LNV PP+++ + ++ +G+ V + C+ +G+P + + W G +
Sbjct: 1159 V---TQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCN-AQGTPLPVIT--WSKGGSTM- 1211
Query: 584 PPPVVPAA--AEAPDHAELRLDAVTRDSSGSYECSVSNDVGS 623
+V PD L +D T +G Y C +N G+
Sbjct: 1212 ---LVDGEHHVSNPD-GTLSIDQATPSDAGIYTCVATNIAGT 1249
Score = 120 bits (302), Expect = 5e-27
Identities = 138/597 (23%), Positives = 223/597 (37%), Gaps = 67/597 (11%)
Query: 41 DNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQ-ETSVFNETLRIERIA 99
D+ S V +REG ++ L+C P P + W K ++ E + L I++
Sbjct: 3062 DSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAE 3121
Query: 100 RTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTV 159
+ G+Y C+A N G K+ ++V + + + N V L C
Sbjct: 3122 VSDTGQYVCRAINVAGRDD-KNFHLNVYVPPSIEGPEREVIVETISN-----PVTLTCDA 3175
Query: 160 NSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVR 219
PP W + +H + D E G +K L++ + D +YTC S
Sbjct: 3176 TGIPPPTIAWLK-----NHKRIENSDSLEVRILSGGSK-LQIARSQHSDSGNYTCIAS-- 3227
Query: 220 NVCGIPDKAITFRLTNTTAPPALK-LSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHG 278
+ KA + + PP++ + + V GENV + C G P P +QW
Sbjct: 3228 ---NMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCN-ANGIPTPLIQWLKD 3283
Query: 279 PGPLPLGAL------AQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNA 332
P+ G A G TL+I D+G Y C ATN G + + N
Sbjct: 3284 GKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDR---------IFNL 3334
Query: 333 TFQITPDVIKESENIQ-----LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVT 387
+TP + + + + + + C P ++ W KNG P +S +
Sbjct: 3335 NVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQIN--WLKNGLPLPLSSHI--- 3389
Query: 388 RNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKG 447
L A + ++ SD Y C+AS A V + + + + PP + G
Sbjct: 3390 ----RLLAAGQVIRIVRAQVSDVAVYTCVAS-NRAGVDNKHYNLQVFA---PPNMDNSMG 3441
Query: 448 RAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRD 507
+TV +GS + C G P P + W R D + L + L + T L+L + +
Sbjct: 3442 TEEITVLKGSSTSMACITDGTPAPSMAWLR-DGQPLGLDAHLTV-STHGMVLQLLKAETE 3499
Query: 508 MSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSS--QDVRQALGRPVLLRCSLLRG 565
SG Y C + G L V PP + S +++ + P+ L C + G
Sbjct: 3500 DSGKYTCIASNEAG----EVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTC-IASG 3554
Query: 566 SPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVG 622
P W G+ LP V LR+ + +G Y C S+ G
Sbjct: 3555 IP--APKMTWMKDGRPLPQTDQVQTLGGG---EVLRISTAQVEDTGRYTCLASSPAG 3606
Score = 118 bits (295), Expect = 3e-26
Identities = 141/583 (24%), Positives = 233/583 (39%), Gaps = 75/583 (12%)
Query: 56 LMLQCLVTGHPRPQVRWTKTAGSASDKFQ-ETSVFNETLRIERIARTQGGRYYCKAENGV 114
L L C+ +G P P++ W K Q +T E LRI GRY C A +
Sbjct: 3546 LELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPA 3605
Query: 115 GVPAIKS-IRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGS 173
G + +RV V P + D+ + + V L C ++ PP W R
Sbjct: 3606 GDDDKEYLVRVHVP----PNIAGTDEPRDI--TVLRNRQVTLECKSDAVPPPVITWLRNG 3659
Query: 174 DTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRL 233
+ L + + + L++ N D A+YTC S N+ G K +
Sbjct: 3660 ERLQATPRVRI--------LSGGRYLQINNADLGDTANYTCVAS--NIAG---KTTREFI 3706
Query: 234 TNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG----ALAQ 289
PP +K ++LV+ ++ ++C+ G P P++ W L ++ +
Sbjct: 3707 LTVNVPPNIK-GGPQSLVILLNKSTVLECIAEGV-PTPRITWRKDGAVLAGNHARYSILE 3764
Query: 290 GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQL 349
G L I S D+G Y C ATN G ++ ++L V + P + N+ +
Sbjct: 3765 NGFLHIQSAHVTDTGRYLCMATNAAGTD-RRRIDLQV--------HVPPSIAPGPTNMTV 3815
Query: 350 GQDLK--LSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTS-SLELIDLH 406
+++ L+C +P K + W KNG L V +N ++S SL +I
Sbjct: 3816 IVNVQTTLACEATGIP--KPSINWRKNG------HLLNVDQNQNSYRLLSSGSLVIISPS 3867
Query: 407 FSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVR 466
D TY C + GA +V++ + VPP+I+ +VT + +PA + C
Sbjct: 3868 VDDTATYECTVT-NGAGDDKRTVDLTVQ---VPPSIADEPTDFLVT--KHAPAVITCTAS 3921
Query: 467 GKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRP 526
G P P + W++ LLP G G + + + +G Y C G R
Sbjct: 3922 GVPFPSIHWTK--NGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHR- 3978
Query: 527 REAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPP 586
V L+V PP ++P ++ L P+LL C G+P + W+ +G
Sbjct: 3979 ---HVTLHVHEPPVIQPQPSELHVILNNPILLPCE-ATGTPSPFIT--WQKEG------- 4025
Query: 587 VVPAAAEAPDHA-----ELRLDAVTRDSSGSYECSVSNDVGSA 624
+ +HA L++ R+ +G+Y C N G+A
Sbjct: 4026 -INVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTA 4067
Score = 116 bits (291), Expect = 9e-26
Identities = 152/627 (24%), Positives = 248/627 (39%), Gaps = 84/627 (13%)
Query: 28 QIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETS 87
++ ++ Q V + S + + + + L+C G P P + W K S
Sbjct: 2001 ELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQ 2060
Query: 88 VFN--ETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQ-YLDEPMLTVHQTVSDVR 144
V + L + + GRY C A N G K +D++ Y+ ++ Q VS
Sbjct: 2061 VLSGGRILALTSAQISDTGRYTCVAVNAAGE---KQRDIDLRVYVPPNIMGEEQNVS--- 2114
Query: 145 GNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNL 204
+ V L C ++ PP W + L + G+ I E VLK+++
Sbjct: 2115 --VLISQAVELLCQSDAIPPPTLTWLKDGHPL--LKKPGLSISE------NRSVLKIEDA 2164
Query: 205 RPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNET-LVVNPGENVTVQCL 263
+ QD YTC+ + NV G +K N PP + S T L V G +++ C
Sbjct: 2165 QVQDTGRYTCEAT--NVAGKTEKNYN---VNIWVPPNIGGSDELTQLTVIEGNLISLLC- 2218
Query: 264 LTGGDPLPQLQWSHGPGPL------PLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNP 317
+ G P P L W P+ + L+ G L I + D+ Y+C A +NV
Sbjct: 2219 ESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVA-SNVAGT 2277
Query: 318 AKKTVNLLVRSMKNATFQITPDVIKESEN-----IQLGQDLKLSCHVDAVPQEKVTYQWF 372
AKK NL V I P + + + G+ + L C V +P VT W
Sbjct: 2278 AKKEYNLQV--------YIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVT--WM 2327
Query: 373 KNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVN 432
K+G P L+ E+ L+L ++H SD G Y+C+A A + D +++
Sbjct: 2328 KDGHP-------LIKAKGVEILDEGHILQLKNIHVSDTGRYVCVA-VNVAGMTDKKYDLS 2379
Query: 433 ISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLE 492
+ + P I + ++V E + L CE G P P + W + +L S L
Sbjct: 2380 VHAP--PSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRIL- 2436
Query: 493 ETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQV-QLNVQFPPEV--EPSSQDVR 549
+ LRL + + + +G Y C N E ++ L+V PP + E + +DV+
Sbjct: 2437 -SGGRMLRLMQTTMEDAGQYTCVVR-----NAAGEERKIFGLSVLVPPHIVGENTLEDVK 2490
Query: 550 QALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDH-----AELRLDA 604
+ V L C + G+P + W GQ P + H L++
Sbjct: 2491 VKEKQSVTLTCE-VTGNP--VPEITWHKDGQ--------PLQEDEAHHIISGGRFLQITN 2539
Query: 605 VTRDSSGSYECSVSNDVGSAACLFQVS 631
V +G Y C S+ G + F ++
Sbjct: 2540 VQVPHTGRYTCLASSPAGHKSRSFSLN 2566
Score = 114 bits (286), Expect = 3e-25
Identities = 153/643 (23%), Positives = 252/643 (39%), Gaps = 92/643 (14%)
Query: 38 VKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIER 97
+K +SERV + + + LQC+ G P P + W K + Q + R+ +
Sbjct: 1828 IKSSGLSERV--VVKYKPVALQCIANGIPNPSITWLKDDQPVNTA-QGNLKIQSSGRVLQ 1884
Query: 98 IART---QGGRYYCKAENGVGVPAIKSIRVDVQY---LDEPMLTVHQTVSDVRGNFYQEK 151
IA+T GRY C A N G + I++ V L++ +++TV
Sbjct: 1885 IAKTLLEDAGRYTCVATNAAGETQ-QHIQLHVHEPPSLEDAGKMLNETV-------LVSN 1936
Query: 152 TVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYAS 211
V L C NP W + + LS S + +++ +++ + D
Sbjct: 1937 PVQLECKAAGNPVPVITWYKDNRLLSGSTS--------MTFLNRGQIIDIESAQISDAGI 1988
Query: 212 YTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVV--NPGENVTVQCLLTGGDP 269
Y C V++ N G + F P++ S N VV NP V ++C G P
Sbjct: 1989 YKC-VAI-NSAGATE---LFYSLQVHVAPSISGSNNMVAVVVNNP---VRLECEARG-IP 2039
Query: 270 LPQLQWSHGPGPLP-----LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNL 324
P L W P+ L L+ G L++ S Q D+G Y C A N G ++ ++L
Sbjct: 2040 APSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEK-QRDIDL 2098
Query: 325 LVRSMKNATFQITPDVIKESENIQ--LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSK 382
V + P+++ E +N+ + Q ++L C DA+P +T W K+G P
Sbjct: 2099 RV--------YVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLT--WLKDGHPLLKKP 2148
Query: 383 RLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTI 442
L ++ N S L++ D D G Y C A+ + + VNI VPP I
Sbjct: 2149 GLSISEN-------RSVLKIEDAQVQDTGRYTCEATNVAGKT-EKNYNVNI---WVPPNI 2197
Query: 443 SVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDG--KLR 500
+TV EG+ L CE G P P ++W + K + +L + G +L+
Sbjct: 2198 GGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKK--KGSPVLTDSMGRVRILSGGRQLQ 2255
Query: 501 LERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQAL---GRPVL 557
+ + + Y C + G + + L V P + S + + G+ +
Sbjct: 2256 ISIAEKSDAALYSCVASNVAG----TAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSIS 2311
Query: 558 LRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAE-LRLDAVTRDSSGSYECS 616
L C ++G P + W G P + E D L+L + +G Y C
Sbjct: 2312 LECE-VQGIPP--PTVTWMKDGH----PLIKAKGVEILDEGHILQLKNIHVSDTGRYVCV 2364
Query: 617 VSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYV 659
N G + +S A P+ +H+ +N S V
Sbjct: 2365 AVNVAGMTDKKYDLSVHA--------PPSIIGNHRSPENISVV 2399
Score = 111 bits (277), Expect = 4e-24
Identities = 174/744 (23%), Positives = 265/744 (35%), Gaps = 114/744 (15%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTKTAGSASD-KFQETSVFNETLRIERIARTQGGRYY 107
++ G+ + L C V P P + W K S + T + + +++I + G Y
Sbjct: 1090 SVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYL 1149
Query: 108 CKAENGVG--VPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLR----CTVNS 161
C A N G A+K L VH RG + + V R C
Sbjct: 1150 CVATNIAGNVTQAVK-------------LNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQG 1196
Query: 162 NPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNV 221
P W +G T+ ++ V L + P D YTC + N+
Sbjct: 1197 TPLPVITWSKGGSTMLVDGEHHVS--------NPDGTLSIDQATPSDAGIYTCVAT--NI 1246
Query: 222 CGIPDKAITFRLTNTTAPPALKLSVNETLVVN-PGENVTVQCLLTGGDPLPQLQWSHGPG 280
G + IT + L+ N T + + C G P P ++W H
Sbjct: 1247 AGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKG-TPKPTIKWLHNGR 1305
Query: 281 PLP-----LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQ 335
L + L G L I SV D+G Y C A N G +K NL V
Sbjct: 1306 ELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERK-YNLKVH-------- 1356
Query: 336 ITPDVIKESENIQ-----LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRND 390
P VIK+ E + L Q L C V+ P + W+K+ S + N
Sbjct: 1357 -VPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPII--MWYKDNVQVTESSTIQTVNNG 1413
Query: 391 PELPAVTSSLELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISVPKGRA 449
L ++ E D G Y C A + G +++V VPPTI
Sbjct: 1414 KILKLFRATPE-------DAGRYSCKAINIAGTSQKYFNIDV-----LVPPTIIGTNFPN 1461
Query: 450 VVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMS 509
V+V L+C+V+G P P + W + K L + L + L L+ R+
Sbjct: 1462 EVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQ-VLHLKNARRNDK 1520
Query: 510 GTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSS--QDVRQALGRPVLLRCSLLRGSP 567
G Y+C + G + ++L + PP ++ + D+ + + L C RG P
Sbjct: 1521 GRYQCTVSNAAGKQAK----DIKLTIYIPPSIKGGNVTTDISVLINSLIKLECET-RGLP 1575
Query: 568 QRIASAVWRFKGQLLPPPPVVPAAAEAPDHAE-LRLDAVTRDSSGSYECSVSNDVGSAAC 626
+ + W GQ P + + A D + L + S +Y C V+N G+A
Sbjct: 1576 --MPAITWYKDGQ----PIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEK 1629
Query: 627 LFQVSAKAYSP---EFYFDTP---------NPTRSHKLSKNYSYVLQWTQREPDAVDPVL 674
F V Y P E TP + T K + N S +L W + D V
Sbjct: 1630 SFHVD--VYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLK---DGVPVKA 1684
Query: 675 NYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPH----SYEVRLTPYTTFGAG 730
N + I + ++ A + +++GQ YI V YEV + G
Sbjct: 1685 NDNIRIEAGGKKLEIMSA---QEIDRGQ---YICVATSVAGEKEIKYEVDVLVPPAIEGG 1738
Query: 731 DMASRIIHYTEPINSPNLSDNTCH 754
D S I + NL + CH
Sbjct: 1739 DETSYFI-----VMVNNLLELDCH 1757
Score = 109 bits (272), Expect = 1e-23
Identities = 140/601 (23%), Positives = 225/601 (37%), Gaps = 90/601 (14%)
Query: 48 YTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFN-ETLRIERIARTQGGRY 106
+ + + L L C VTG P P + W K ++ + N L I + + G Y
Sbjct: 1744 FIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLY 1803
Query: 107 YCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQE------KTVFLRCTVN 160
C A N G + E +TVH ++ + E K V L+C N
Sbjct: 1804 RCMAANTAG-----------DHKKEFEVTVH-VPPTIKSSGLSERVVVKYKPVALQCIAN 1851
Query: 161 SNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRN 220
P W + ++ +Q N L Q +VL++ +D YTC + N
Sbjct: 1852 GIPNPSITWLKDDQPVNTAQGN-------LKIQSSGRVLQIAKTLLEDAGRYTCVAT--N 1902
Query: 221 VCGIPDKAITFRLTNTTAPPALK---LSVNET-LVVNPGENVTVQCLLTGGDPLPQLQWS 276
G + I + PP+L+ +NET LV NP V ++C G+P+P + W
Sbjct: 1903 AAGETQQHIQLHVHE---PPSLEDAGKMLNETVLVSNP---VQLEC-KAAGNPVPVITWY 1955
Query: 277 HG----PGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNA 332
G + L +G + I S Q D+G Y C A N+ G +
Sbjct: 1956 KDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAG---------ATELFYSL 2006
Query: 333 TFQITPDVIKESEN---IQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRN 389
+ P I S N + + ++L C +P +T W K+G P L +
Sbjct: 2007 QVHVAPS-ISGSNNMVAVVVNNPVRLECEARGIPAPSLT--WLKDGSPVSSFSNGLQVLS 2063
Query: 390 DPELPAVTSSLELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISVPKGR 448
+ A+TS+ SD G Y C+A + G D+ + V VPP I +
Sbjct: 2064 GGRILALTSA------QISDTGRYTCVAVNAAGEKQRDIDLRV-----YVPPNIMGEEQN 2112
Query: 449 AVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDM 508
V + + EL C+ P P + W + D L GL + E L++E
Sbjct: 2113 VSVLISQA--VELLCQSDAIPPPTLTWLK-DGHPLLKKPGLSISEN-RSVLKIEDAQVQD 2168
Query: 509 SGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQAL--GRPVLLRCSLLRGS 566
+G Y C+ G E +N+ PP + S + + + G + L C
Sbjct: 2169 TGRYTCEATNVAG----KTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIP 2224
Query: 567 PQRIASAVWRFKGQLLPPPPVVPAAAEA---PDHAELRLDAVTRDSSGSYECSVSNDVGS 623
P + +W+ KG P + + +L++ + + Y C SN G+
Sbjct: 2225 PPNL---IWKKKGS----PVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGT 2277
Query: 624 A 624
A
Sbjct: 2278 A 2278
Score = 108 bits (270), Expect = 2e-23
Identities = 149/633 (23%), Positives = 238/633 (37%), Gaps = 71/633 (11%)
Query: 16 CRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQC-LVTGHPRPQVRWTK 74
C + + Q++ V IS V + EG L L C L+ G+P P+ RW K
Sbjct: 867 CEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIK 926
Query: 75 TAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPML 134
+ T + +L IER+ GG Y C A N G K+ V V L +
Sbjct: 927 NSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNN-KTTSVVVHVL-PTIQ 984
Query: 135 TVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQG 194
Q +S + G V L C + NP IW + + +S S ++ G
Sbjct: 985 HGQQILSTIEG-----IPVTLPCKASGNPKPSVIWSKKGELISTSSAK--------FSAG 1031
Query: 195 ETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPAL----KLSVNETL 250
L + + ++ Y C + N G + + +LT P LS ++ +
Sbjct: 1032 ADGSLYVVSPGGEESGEYVC--TATNTAGYAKRKV--QLTVYVRPRVFGDQRGLSQDKPV 1087
Query: 251 VVN--PGENVTVQCLLTGGDPLPQLQWSHGPGPL----PLGALAQGGTLSIPSVQARDSG 304
++ GE VT+ C + P P + W+ + P G++ I + DSG
Sbjct: 1088 EISVLAGEEVTLPCEVKSLPP-PIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSG 1146
Query: 305 YYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQ 364
Y C ATN GN + V L V Q P +K +Q+GQ + + C+ P
Sbjct: 1147 MYLCVATNIAGN-VTQAVKLNVHVPPK--IQRGPKHLK----VQVGQRVDIPCNAQGTPL 1199
Query: 365 EKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMA-SFPGAP 423
+T W K G + V+ D +L + SD G Y C+A + G
Sbjct: 1200 PVIT--WSKGGSTMLVDGEHHVSNPD-------GTLSIDQATPSDAGIYTCVATNIAGTD 1250
Query: 424 VPDLSVEVNISSETVPPTISVPKGRAVVTVRE---GSPAELQCEVRGKPRPPVLWSRVDK 480
++++ V PPT+ + T +E E C +G P+P + W +
Sbjct: 1251 ETEITLHVQ-----EPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGR 1305
Query: 481 EAALLPSGLPLEETPDGKLR-LERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPP 539
E G+ + E DG L + V+ +G Y C G E + L V PP
Sbjct: 1306 ELTGREPGISILE--DGTLLVIASVTPYDNGEYICVAVNEAG----TTERKYNLKVHVPP 1359
Query: 540 EVEPSSQ--DVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDH 597
++ Q +V L + L C + G+P I +W + +
Sbjct: 1360 VIKDKEQVTNVSVLLNQLTNLFCE-VEGTPSPI--IMWYKDNVQVTESSTIQTVNNG--- 1413
Query: 598 AELRLDAVTRDSSGSYECSVSNDVGSAACLFQV 630
L+L T + +G Y C N G++ F +
Sbjct: 1414 KILKLFRATPEDAGRYSCKAINIAGTSQKYFNI 1446
Score = 107 bits (267), Expect = 5e-23
Identities = 159/657 (24%), Positives = 248/657 (37%), Gaps = 97/657 (14%)
Query: 58 LQCLVTGHPRPQVRWTKTAGSASDKFQETS---VFNETLRIERIARTQGGRYYCKAENGV 114
L C TG P+P + W K + + S + + +L I + Y C NG
Sbjct: 3823 LACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGA 3882
Query: 115 GVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEK--TVFLRCTVNSNPPARFIWKRG 172
G +++ + VQ V +++D +F K + CT + P W +
Sbjct: 3883 GDDK-RTVDLTVQ--------VPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKN 3933
Query: 173 SDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFR 232
L D Y + +++ + YTC RN G + +T
Sbjct: 3934 GIRLLPRGDG--------YRILSSGAIEILATQLNHAGRYTCVA--RNAAGSAHRHVTLH 3983
Query: 233 LTNTTAPPALKLSVNETLVV--NPGENVTVQCLLTGGDPLPQLQWS-HGPGPLPLG---A 286
+ PP ++ +E V+ NP + + C TG P P + W G G A
Sbjct: 3984 VHE---PPVIQPQPSELHVILNNP---ILLPCEATG-TPSPFITWQKEGINVNTSGRNHA 4036
Query: 287 LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESEN 346
+ G L I D+G Y C A N G K Q+ P + +
Sbjct: 4037 VLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKI---------KLNVQVPPVISPHLKE 4087
Query: 347 IQLGQD--LKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELID 404
+ D + LSC D +P +T W K+G+ S R V + SL++
Sbjct: 4088 YVIAVDKPITLSCEADGLPPPDIT--WHKDGRAIVESIRQRVLSS--------GSLQIAF 4137
Query: 405 LHFSDYGTYLCMAS-FPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQC 463
+ D G Y CMA+ G+ + V+ VPP I +G TV E S A L C
Sbjct: 4138 VQPGDAGHYTCMAANVAGSSSTSTKLTVH-----VPPRIRSTEGH--YTVNENSQAILPC 4190
Query: 464 EVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFN 523
G P P + W + + A L E P G+L LE V + SG Y C G +
Sbjct: 4191 VADGIPTPAINWKKDNVLLANLLGKYTAE--PYGELILENVVLEDSGFYTCVANNAAGED 4248
Query: 524 VRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLP 583
V L V P DV G + L C G P + W F
Sbjct: 4249 THT----VSLTVHVLPTFTELPGDVSLNKGEQLRLSCKAT-GIP--LPKLTWTFNNN--- 4298
Query: 584 PPPVVPAAAEAPD-HAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFD 642
++PA ++ + H+EL ++ V+++ SG+Y C+ N VG + V K P F D
Sbjct: 4299 ---IIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKE-PPVFKGD 4354
Query: 643 TP---------NPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVV 690
P N + ++ + + +QW ++ VD +++R IRQL + +
Sbjct: 4355 YPSNWIEPLGGNAILNCEVKGDPTPTIQWNRK---GVDIEISHR--IRQLGNGSLAI 4406
Score = 106 bits (264), Expect = 1e-22
Identities = 164/678 (24%), Positives = 251/678 (37%), Gaps = 133/678 (19%)
Query: 18 GQGVYAPAQAQIVHAGQ-ACVV------KEDNISERVY------------TIREGDTLML 58
G + A AQI G+ CV K+ +I RVY ++ + L
Sbjct: 2064 GGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVEL 2123
Query: 59 QCLVTGHPRPQVRWTKTAGSASDK-FQETSVFNETLRIERIARTQGGRYYCKAENGVGVP 117
C P P + W K K S L+IE GRY C+A N G
Sbjct: 2124 LCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKT 2183
Query: 118 AIKSIRVDVQY------LDE-PMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWK 170
K+ V++ DE LTV + GN + L C + PP IWK
Sbjct: 2184 E-KNYNVNIWVPPNIGGSDELTQLTV------IEGNL-----ISLLCESSGIPPPNLIWK 2231
Query: 171 R-GSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAI 229
+ GS L+ S + + L++ D A Y+C S NV G K
Sbjct: 2232 KKGSPVLTDSMGR-------VRILSGGRQLQISIAEKSDAALYSCVAS--NVAGTAKKEY 2282
Query: 230 TFR------LTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPL- 282
+ +TN+ + P ++V G++++++C + G P P + W PL
Sbjct: 2283 NLQVYIRPTITNSGSHPT-------EIIVTRGKSISLECEVQGIPP-PTVTWMKDGHPLI 2334
Query: 283 ---PLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPD 339
+ L +G L + ++ D+G Y C A N G KK + + P
Sbjct: 2335 KAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKY---------DLSVHAPPS 2385
Query: 340 VI---KESENIQLGQ--DLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELP 394
+I + ENI + + + L+C +P +T WFK+G P +S + + L
Sbjct: 2386 IIGNHRSPENISVVEKNSVSLTCEASGIPLPSIT--WFKDGWPVSLSNSVRILSGGRMLR 2443
Query: 395 AVTSSLELIDLHFSDYGTYLCM---ASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVV 451
+ +++E D G Y C+ A+ + LSV VPP I V
Sbjct: 2444 LMQTTME-------DAGQYTCVVRNAAGEERKIFGLSV-------LVPPHIVGENTLEDV 2489
Query: 452 TVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEE------TPDGK-LRLERV 504
V+E L CEV G P P + W + G PL+E G+ L++ V
Sbjct: 2490 KVKEKQSVTLTCEVTGNPVPEITWHK---------DGQPLQEDEAHHIISGGRFLQITNV 2540
Query: 505 SRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV-----EPSSQDVRQALGRPVLLR 559
+G Y C + G R LNV P + + + +DV L P L
Sbjct: 2541 QVPHTGRYTCLASSPAGHKSR----SFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLV 2596
Query: 560 CSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSN 619
C P A+ W G L + P L++ D++G Y C +N
Sbjct: 2597 CEAYSYPP---ATITWFKDGTPLESNRNIRI---LPGGRTLQILNAQEDNAGRYSCVATN 2650
Query: 620 DVGSAACLFQVSAKAYSP 637
+ G ++V K Y P
Sbjct: 2651 EAGEMIKHYEV--KVYIP 2666
Score = 102 bits (255), Expect = 1e-21
Identities = 139/629 (22%), Positives = 229/629 (36%), Gaps = 75/629 (11%)
Query: 40 EDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSAS-DKFQETSVFNETLRIERI 98
++++ T+ +G + + C+ G P P + W + D S L++ +
Sbjct: 3437 DNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKA 3496
Query: 99 ARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLT---VHQTVSDVRGNFYQEKTVFL 155
G+Y C A N G + I ++ L+ P + H+ +S + N + L
Sbjct: 3497 ETEDSGKYTCIASNEAGEVSKHFI---LKVLEPPHINGSEEHEEISVIVNN-----PLEL 3548
Query: 156 RCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQ 215
C + P + W + L + + + T G +VL++ + +D YTC
Sbjct: 3549 TCIASGIPAPKMTWMKDGRPLPQT--------DQVQTLGGGEVLRISTAQVEDTGRYTCL 3600
Query: 216 VSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQW 275
S + G DK R+ P + V VT++C + P P + W
Sbjct: 3601 AS--SPAGDDDKEYLVRV--HVPPNIAGTDEPRDITVLRNRQVTLEC-KSDAVPPPVITW 3655
Query: 276 SHGPGPLP----LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKN 331
L + L+ G L I + D+ Y C A+N G ++ +
Sbjct: 3656 LRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFI--------- 3706
Query: 332 ATFQITPDVI--KESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKP-ARMSKRLLVTR 388
T + P++ +S I L + L C + VP ++T W K+G A R +
Sbjct: 3707 LTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRIT--WRKDGAVLAGNHARYSILE 3764
Query: 389 NDPELPAVTSSLELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISVPKG 447
N L + H +D G YLCMA + G + ++V+ VPP S+ G
Sbjct: 3765 N--------GFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVH-----VPP--SIAPG 3809
Query: 448 RAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRD 507
+TV L CE G P+P + W + + + G L + S D
Sbjct: 3810 PTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVD 3869
Query: 508 MSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSP 567
+ TY C G + R V L VQ PP + D P ++ C+ S
Sbjct: 3870 DTATYECTVTNGAGDDKR----TVDLTVQVPPSIADEPTDFLVTKHAPAVITCT---ASG 3922
Query: 568 QRIASAVWRFKG-QLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAAC 626
S W G +LLP + + A + +G Y C N GSA
Sbjct: 3923 VPFPSIHWTKNGIRLLPRGD----GYRILSSGAIEILATQLNHAGRYTCVARNAAGSAH- 3977
Query: 627 LFQVSAKAYSPEFYFDTPNPTRSHKLSKN 655
V+ + P P P+ H + N
Sbjct: 3978 -RHVTLHVHEPPVI--QPQPSELHVILNN 4003
Score = 100 bits (248), Expect = 8e-21
Identities = 129/539 (23%), Positives = 212/539 (39%), Gaps = 62/539 (11%)
Query: 93 LRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKT 152
L I ++ + G Y C A + G ++ DV P++ V V+ G E+
Sbjct: 484 LDIAKVTLSDEGFYECIAVSSAGTGRAQTF-FDVSE-PPPVIQVPNNVTVTPG----ERA 537
Query: 153 VFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKV-LKLKNLRPQDYAS 211
V L C + S W+R D V + EP + + L+LK+++ D
Sbjct: 538 V-LTCLIISAVDYNLTWQRN--------DRDVRLAEPARIRTLANLSLELKSVKFNDAGE 588
Query: 212 YTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLP 271
Y C VS A + LT P + N++ G V++ C TG P P
Sbjct: 589 YHCMVSSEG----GSSAASVFLTVQEPPKVTVMPKNQSFT--GGSEVSIMCSATGY-PKP 641
Query: 272 QLQWSHGPGPLPLGA----LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVR 327
++ W+ + +G+ + GTL I + +D+G Y C A+N+ G + + +
Sbjct: 642 KIAWTVNDMFI-VGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIE 700
Query: 328 SMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVT 387
+ K V++ + LG + C +P +V +WFK R S L++
Sbjct: 701 APKLM-------VVQSELLVALGDITVMECKTSGIPPPQV--KWFKGDLELRPSTFLII- 750
Query: 388 RNDPELPAVTSSLELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISVPK 446
DP L L++ + D G Y C+A + G ++++V + P I P
Sbjct: 751 --DPLL----GLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVG----SPPVFIQEP- 799
Query: 447 GRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLP--SGLPLEETPDGKLRLERV 504
A V++ GS L C V+G P P + W R+D S + + G L + +
Sbjct: 800 --ADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNL 857
Query: 505 SRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLR 564
GTY C+ N F E V + P + S G+ + L C+LL
Sbjct: 858 WASDKGTYICEAE--NQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLA 915
Query: 565 GSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGS 623
G+P I W +L P + ++ L ++ V G Y C SN G+
Sbjct: 916 GNP--IPERRWIKNSAMLLQNPYITVRSD----GSLHIERVQLQDGGEYTCVASNVAGT 968
Score = 99.4 bits (246), Expect = 1e-20
Identities = 114/440 (25%), Positives = 175/440 (39%), Gaps = 62/440 (14%)
Query: 48 YTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYY 107
Y I + L C G P P + W K + + ++ + + +L+I + G Y
Sbjct: 4088 YVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYT 4147
Query: 108 CKAENGVGVPAIKSIRVDVQYLDEPMLTVH--QTVSDVRGNF--YQEKTVFLRCTVNSNP 163
C A N G + + LTVH + G++ + L C + P
Sbjct: 4148 CMAANVAGSSSTST-----------KLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIP 4196
Query: 164 PARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCG 223
WK+ + L++ YT L L+N+ +D YTC + N G
Sbjct: 4197 TPAINWKKDNVLLANLLGK--------YTAEPYGELILENVVLEDSGFYTCVAN--NAAG 4246
Query: 224 IPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP 283
+ T LT P +L + +L N GE + + C T G PLP+L W+ +P
Sbjct: 4247 --EDTHTVSLTVHVLPTFTELPGDVSL--NKGEQLRLSCKAT-GIPLPKLTWTFNNNIIP 4301
Query: 284 LGALAQGG--TLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVI 341
+ G L I V DSG Y CTA N+VG V+++ + P V
Sbjct: 4302 AHFDSVNGHSELVIERVSKEDSGTYVCTAENSVG---------FVKAI-GFVYVKEPPVF 4351
Query: 342 K---ESENIQ-LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVT 397
K S I+ LG + L+C V P T QW + G +S R+ N
Sbjct: 4352 KGDYPSNWIEPLGGNAILNCEVKGDPTP--TIQWNRKGVDIEISHRIRQLGN-------- 4401
Query: 398 SSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGS 457
SL + D G Y C+A+ A V + S+ + + S PP I++ V+ G
Sbjct: 4402 GSLAIYGTVNEDAGDYTCVAT-NEAGVVERSMSLTLQS---PPIITLEPVETVINA--GG 4455
Query: 458 PAELQCEVRGKPRPPVLWSR 477
L C+ G+P+P + WSR
Sbjct: 4456 KIILNCQATGEPQPTITWSR 4475
Score = 99.0 bits (245), Expect = 2e-20
Identities = 135/590 (22%), Positives = 220/590 (37%), Gaps = 70/590 (11%)
Query: 55 TLMLQCLVTGHPRPQVRWTKTAG--SASDKFQETSVFNETLRIERIARTQGGRYYCKAEN 112
+L L+C G+P P + W K A+D + + L I G+Y C A +
Sbjct: 1658 SLTLECKAAGNPSPILTWLKDGVPVKANDNIR-IEAGGKKLEIMSAQEIDRGQYICVATS 1716
Query: 113 GVGVPAIKSIRVDVQYLDEPMLTVHQTVSD--VRGNFYQEKTVFLRCTVNSNPPARFIWK 170
G K I+ +V L P + S V N E L C V +PP +W
Sbjct: 1717 VAGE---KEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLE----LDCHVTGSPPPTIMWL 1769
Query: 171 RGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAIT 230
+ + + + + L + + + Y C + N G D
Sbjct: 1770 KDGQLIDERDGFKILL--------NGRKLVIAQAQVSNTGLYRCMAA--NTAG--DHKKE 1817
Query: 231 FRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP-----LG 285
F +T PP +K S VV + V +QC+ G P P + W P+ L
Sbjct: 1818 FEVT-VHVPPTIKSSGLSERVVVKYKPVALQCI-ANGIPNPSITWLKDDQPVNTAQGNLK 1875
Query: 286 ALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVR---SMKNATFQITPDVIK 342
+ G L I D+G Y C ATN G ++ + L V S+++A +
Sbjct: 1876 IQSSGRVLQIAKTLLEDAGRYTCVATNAAGE-TQQHIQLHVHEPPSLEDAGKML------ 1928
Query: 343 ESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLEL 402
+E + + ++L C P +T W+K+ RLL +++
Sbjct: 1929 -NETVLVSNPVQLECKAAGNPVPVIT--WYKDN-------RLLSGSTSMTFLNRGQIIDI 1978
Query: 403 IDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAEL 461
SD G Y C+A + GA S++V+++ P+IS V V +P L
Sbjct: 1979 ESAQISDAGIYKCVAINSAGATELFYSLQVHVA-----PSISGSNNMVAVVVN--NPVRL 2031
Query: 462 QCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNG 521
+CE RG P P + W + + +GL + G L S +S T R N
Sbjct: 2032 ECEARGIPAPSLTWLKDGSPVSSFSNGL---QVLSGGRILALTSAQISDTGRYTCVAVNA 2088
Query: 522 FNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQL 581
+ R+ + L V PP + Q+V + + V L C P + W G
Sbjct: 2089 AGEKQRD--IDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTL---TWLKDGH- 2142
Query: 582 LPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVS 631
P P + + + + L+++ +G Y C +N G + V+
Sbjct: 2143 --PLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVN 2190
Score = 75.1 bits (183), Expect = 3e-13
Identities = 94/388 (24%), Positives = 148/388 (38%), Gaps = 64/388 (16%)
Query: 44 SERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKF-QETSVFNETLRIERIARTQ 102
+E YT+ E +L C+ G P P + W K ++ + T+ L +E +
Sbjct: 4174 TEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLED 4233
Query: 103 GGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVH--QTVSDVRGNFYQEKTVFLR--CT 158
G Y C A N G + LTVH T +++ G+ K LR C
Sbjct: 4234 SGFYTCVANNAAG-----------EDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCK 4282
Query: 159 VNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSV 218
P + W ++ + D+ G ++ L ++ + +D +Y C +
Sbjct: 4283 ATGIPLPKLTWTFNNNIIPAHFDS---------VNGHSE-LVIERVSKEDSGTYVC--TA 4330
Query: 219 RNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQW--- 275
N G KAI F PP K + G N + C + GDP P +QW
Sbjct: 4331 ENSVGFV-KAIGF--VYVKEPPVFKGDYPSNWIEPLGGNAILNCEVK-GDPTPTIQWNRK 4386
Query: 276 ------SHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSM 329
SH L G+LA GT++ D+G Y C ATN G +++++L ++S
Sbjct: 4387 GVDIEISHRIRQLGNGSLAIYGTVN------EDAGDYTCVATNEAG-VVERSMSLTLQSP 4439
Query: 330 KNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRN 389
T + V I G + L+C PQ +T W + G R+ V N
Sbjct: 4440 PIITLEPVETV------INAGGKIILNCQATGEPQPTIT--WSRQGHSISWDDRVNVLSN 4491
Query: 390 DPELPAVTSSLELIDLHFSDYGTYLCMA 417
+SL + D D + C+A
Sbjct: 4492 --------NSLYIADAQKEDTSEFECVA 4511
Score = 36.2 bits (82), Expect = 0.15
Identities = 18/66 (27%), Positives = 30/66 (45%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCK 109
I G ++L C TG P+P + W++ S S + + N +L I + + C
Sbjct: 4451 INAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECV 4510
Query: 110 AENGVG 115
A N +G
Sbjct: 4511 ARNLMG 4516
Score = 33.9 bits (76), Expect = 0.75
Identities = 32/135 (23%), Positives = 53/135 (39%), Gaps = 9/135 (6%)
Query: 491 LEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQ 550
L+E+ L + +V+ G Y C G AQ +V PP V +V
Sbjct: 476 LKESASVNLDIAKVTLSDEGFYECIAVSSAGTG----RAQTFFDVSEPPPVIQVPNNVTV 531
Query: 551 ALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSS 610
G +L C ++ + W+ + + PA + L L +V + +
Sbjct: 532 TPGERAVLTCLIISAVDYNLT---WQRNDRDVRLAE--PARIRTLANLSLELKSVKFNDA 586
Query: 611 GSYECSVSNDVGSAA 625
G Y C VS++ GS+A
Sbjct: 587 GEYHCMVSSEGGSSA 601
>gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 125 bits (313), Expect = 2e-28
Identities = 81/199 (40%), Positives = 112/199 (56%), Gaps = 21/199 (10%)
Query: 740 TEPIN-SPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDIS-G 797
T+ +N +P L C+FE IC + QD D+FDWTR +Q P + NTGP D + G
Sbjct: 494 TDEVNCAPELQ---CNFETG-ICNWEQDAKDDFDWTR----SQGPTPTLNTGPMKDNTLG 545
Query: 798 TPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCV-SFFYHMYGKHIGSLNLLVR--S 854
T +G+Y++IE+S P+ D A L+SP+ NA+ C F+YHM+GK I L + R S
Sbjct: 546 TAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWS 605
Query: 855 RNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDV----- 909
++G L W + GN+GN W + H+ IS PFQI+ E G G+ GDIAIDD+
Sbjct: 606 DSRGQL---LWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMDC 662
Query: 910 TLKKGECPRKQTDPNKVVV 928
TL G P P + V
Sbjct: 663 TLYPGNLPADLPTPPETSV 681
Score = 85.5 bits (210), Expect = 2e-16
Identities = 55/167 (32%), Positives = 89/167 (53%), Gaps = 14/167 (8%)
Query: 749 SDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDIS-GTPEGYYMFIE 807
S C FE + +C + Q+ ++FDW L + + T P D + G G+Y+FI+
Sbjct: 943 SSGRCDFEFD-LCSWKQEKDEDFDWN----LKASSIPAAGTEPAADHTLGNSSGHYIFIK 997
Query: 808 TSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLL---VRSRNKGALDTHA 864
+ P++ AR+ SP+ + +K + F YHMYG IG+L L+ V ++ K L
Sbjct: 998 SLFPQQPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLL---- 1053
Query: 865 WSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTL 911
+L+ +GN W++ + + FQ+ FEG G G GDIA+DD+ L
Sbjct: 1054 -NLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVL 1099
Score = 79.7 bits (195), Expect = 1e-14
Identities = 42/167 (25%), Positives = 85/167 (50%), Gaps = 11/167 (6%)
Query: 753 CHFEDEKICGYTQDL-------TDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMF 805
C FE +C + Q + ++ F W N ++ + + T +G+Y++
Sbjct: 730 CSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLY 789
Query: 806 IETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAW 865
++S + GD A +++P+ + + + F+ HM G +GSL +L++ N + + W
Sbjct: 790 ADSSNGK-FGDTADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDN---VTSKLW 845
Query: 866 SLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLK 912
+ +G +G W++A V + QI+F RG Y+GD+A+DD++ +
Sbjct: 846 AQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQ 892
Score = 59.3 bits (142), Expect = 2e-08
Identities = 47/178 (26%), Positives = 78/178 (43%), Gaps = 5/178 (2%)
Query: 742 PINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDIS-GTPE 800
P S + C FE + D+FDW R + ++ + PP D S +
Sbjct: 283 PRTSTQSKFSKCDFEANSCDWFEAISGDHFDWIRSSQ-SELSADFEHQAPPRDHSLNASQ 341
Query: 801 GYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGAL 860
G++MFI + L A+L SP ++ + +SF+++ YG +G+ L + N
Sbjct: 342 GHFMFI-LKKSSSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHD- 399
Query: 861 DTHAWSLSGNKGNVWQQAHVPISP-SGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECP 917
T W + N+G W +A + + S PF + + V Y G AIDD+ + P
Sbjct: 400 STVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLP 457
Score = 58.5 bits (140), Expect = 3e-08
Identities = 54/209 (25%), Positives = 87/209 (41%), Gaps = 33/209 (15%)
Query: 738 HYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWT-----RQNALTQNPKRSPNTGPP 792
HYT S N ++ ++ C TQD D+ DW AL + +P +G
Sbjct: 1431 HYTSTTGSCNFETSSGNWTTA--CSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQ- 1487
Query: 793 TDISGTPEGYYMFIETSRPRELGDRARLV-SPLYNASAKFYCVSFFYHMYGKHIGSLNLL 851
+++++ +S +E G AR+ S + AS V F+++M + L
Sbjct: 1488 ---------HFLYVNSSGSKE-GSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGI-LK 1536
Query: 852 VRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTL 911
V + + L+ WS+ GNK W VP+S + PF++ FE IA+DD++
Sbjct: 1537 VYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISF 1596
Query: 912 KKGECPRKQTDPNKVVVMPGSGAPCQSSP 940
EC + G P Q SP
Sbjct: 1597 TP-EC------------VTGGPVPVQPSP 1612
Score = 32.7 bits (73), Expect = 1.7
Identities = 14/52 (26%), Positives = 30/52 (57%)
Query: 802 YYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVR 853
++M++E + GD+A S ++ S+ +SF+Y + K GS+ +L++
Sbjct: 1264 HFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFVSAKATGSIQILIK 1315
>gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1542
Score = 124 bits (312), Expect = 3e-28
Identities = 81/199 (40%), Positives = 111/199 (55%), Gaps = 21/199 (10%)
Query: 740 TEPIN-SPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDIS-G 797
T+ +N +P L C+FE IC + QD D+FDWTR Q P + NTGP D + G
Sbjct: 219 TDEVNCAPELQ---CNFETG-ICNWEQDAKDDFDWTRN----QGPTPTLNTGPMKDNTLG 270
Query: 798 TPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCV-SFFYHMYGKHIGSLNLLVR--S 854
T +G+Y++IE+S P+ D A L+SP+ NA+ C F+YHM+GK I L + R S
Sbjct: 271 TAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWS 330
Query: 855 RNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDV----- 909
++G L W + GN+GN W + H+ IS PFQI+ E G G+ GDIAIDD+
Sbjct: 331 DSRGQL---LWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMDC 387
Query: 910 TLKKGECPRKQTDPNKVVV 928
TL G P P + V
Sbjct: 388 TLYPGNLPADLPTPPETSV 406
Score = 85.1 bits (209), Expect = 3e-16
Identities = 55/167 (32%), Positives = 88/167 (52%), Gaps = 14/167 (8%)
Query: 749 SDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDIS-GTPEGYYMFIE 807
S C FE + +C + Q+ ++FDW L + + T P D + G G+Y+FI
Sbjct: 668 SSGRCDFEFD-LCSWKQEKDEDFDWN----LKASSIPAAGTEPAADHTLGNSSGHYIFIN 722
Query: 808 TSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLL---VRSRNKGALDTHA 864
+ P++ AR+ SP+ + +K + F YHMYG IG+L L+ V ++ K L
Sbjct: 723 SLFPQQPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLL---- 778
Query: 865 WSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTL 911
+L+ +GN W++ + + FQ+ FEG G G GDIA+DD+ L
Sbjct: 779 -NLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVL 824
Score = 79.7 bits (195), Expect = 1e-14
Identities = 42/167 (25%), Positives = 85/167 (50%), Gaps = 11/167 (6%)
Query: 753 CHFEDEKICGYTQDL-------TDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMF 805
C FE +C + Q + ++ F W N ++ + + T +G+Y++
Sbjct: 455 CSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLY 514
Query: 806 IETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAW 865
++S + GD A +++P+ + + + F+ HM G +GSL +L++ N + + W
Sbjct: 515 ADSSNGK-FGDTADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDN---VTSKLW 570
Query: 866 SLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLK 912
+ +G +G W++A V + QI+F RG Y+GD+A+DD++ +
Sbjct: 571 AQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQ 617
Score = 59.7 bits (143), Expect = 1e-08
Identities = 47/179 (26%), Positives = 81/179 (45%), Gaps = 5/179 (2%)
Query: 741 EPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDIS-GTP 799
E ++S + + C FE + D+FDW R + ++ + PP D S
Sbjct: 7 EILSSMKIWVSKCDFEANSCDWFEAISGDHFDWIRSSQ-SELSADFEHQAPPRDHSLNAS 65
Query: 800 EGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGA 859
+G++MFI + L A+L SP ++ + +SF+++ YG +G+ L + N
Sbjct: 66 QGHFMFI-LKKSSSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHD 124
Query: 860 LDTHAWSLSGNKGNVWQQAHVPISP-SGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECP 917
T W + N+G W +A + + S PF + + V Y G AIDD+ + P
Sbjct: 125 -STVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLP 182
Score = 58.5 bits (140), Expect = 3e-08
Identities = 54/209 (25%), Positives = 87/209 (41%), Gaps = 33/209 (15%)
Query: 738 HYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWT-----RQNALTQNPKRSPNTGPP 792
HYT S N ++ ++ C TQD D+ DW AL + +P +G
Sbjct: 1156 HYTSTTGSCNFETSSGNWTTA--CSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQ- 1212
Query: 793 TDISGTPEGYYMFIETSRPRELGDRARLV-SPLYNASAKFYCVSFFYHMYGKHIGSLNLL 851
+++++ +S +E G AR+ S + AS V F+++M + L
Sbjct: 1213 ---------HFLYVNSSGSKE-GSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGI-LK 1261
Query: 852 VRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTL 911
V + + L+ WS+ GNK W VP+S + PF++ FE IA+DD++
Sbjct: 1262 VYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISF 1321
Query: 912 KKGECPRKQTDPNKVVVMPGSGAPCQSSP 940
EC + G P Q SP
Sbjct: 1322 TP-EC------------VTGGPVPVQPSP 1337
Score = 32.7 bits (73), Expect = 1.7
Identities = 14/52 (26%), Positives = 30/52 (57%)
Query: 802 YYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVR 853
++M++E + GD+A S ++ S+ +SF+Y + K GS+ +L++
Sbjct: 989 HFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFISAKATGSIQILIK 1040
>gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 124 bits (312), Expect = 3e-28
Identities = 81/199 (40%), Positives = 111/199 (55%), Gaps = 21/199 (10%)
Query: 740 TEPIN-SPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDIS-G 797
T+ +N +P L C+FE IC + QD D+FDWTR Q P + NTGP D + G
Sbjct: 494 TDEVNCAPELQ---CNFETG-ICNWEQDAKDDFDWTRN----QGPTPTLNTGPMKDNTLG 545
Query: 798 TPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCV-SFFYHMYGKHIGSLNLLVR--S 854
T +G+Y++IE+S P+ D A L+SP+ NA+ C F+YHM+GK I L + R S
Sbjct: 546 TAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWS 605
Query: 855 RNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDV----- 909
++G L W + GN+GN W + H+ IS PFQI+ E G G+ GDIAIDD+
Sbjct: 606 DSRGQL---LWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMDC 662
Query: 910 TLKKGECPRKQTDPNKVVV 928
TL G P P + V
Sbjct: 663 TLYPGNLPADLPTPPETSV 681
Score = 85.5 bits (210), Expect = 2e-16
Identities = 55/167 (32%), Positives = 89/167 (53%), Gaps = 14/167 (8%)
Query: 749 SDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDIS-GTPEGYYMFIE 807
S C FE + +C + Q+ ++FDW L + + T P D + G G+Y+FI+
Sbjct: 943 SSGRCDFEFD-LCSWKQEKDEDFDWN----LKASSIPAAGTEPAADHTLGNSSGHYIFIK 997
Query: 808 TSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLL---VRSRNKGALDTHA 864
+ P++ AR+ SP+ + +K + F YHMYG IG+L L+ V ++ K L
Sbjct: 998 SLFPQQPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLL---- 1053
Query: 865 WSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTL 911
+L+ +GN W++ + + FQ+ FEG G G GDIA+DD+ L
Sbjct: 1054 -NLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVL 1099
Score = 79.7 bits (195), Expect = 1e-14
Identities = 42/167 (25%), Positives = 85/167 (50%), Gaps = 11/167 (6%)
Query: 753 CHFEDEKICGYTQDL-------TDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMF 805
C FE +C + Q + ++ F W N ++ + + T +G+Y++
Sbjct: 730 CSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLY 789
Query: 806 IETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAW 865
++S + GD A +++P+ + + + F+ HM G +GSL +L++ N + + W
Sbjct: 790 ADSSNGK-FGDTADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDN---VTSKLW 845
Query: 866 SLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLK 912
+ +G +G W++A V + QI+F RG Y+GD+A+DD++ +
Sbjct: 846 AQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQ 892
Score = 59.3 bits (142), Expect = 2e-08
Identities = 47/178 (26%), Positives = 78/178 (43%), Gaps = 5/178 (2%)
Query: 742 PINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDIS-GTPE 800
P S + C FE + D+FDW R + ++ + PP D S +
Sbjct: 283 PRTSTQSKFSKCDFEANSCDWFEAISGDHFDWIRSSQ-SELSADFEHQAPPRDHSLNASQ 341
Query: 801 GYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGAL 860
G++MFI + L A+L SP ++ + +SF+++ YG +G+ L + N
Sbjct: 342 GHFMFI-LKKSSSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHD- 399
Query: 861 DTHAWSLSGNKGNVWQQAHVPISP-SGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECP 917
T W + N+G W +A + + S PF + + V Y G AIDD+ + P
Sbjct: 400 STVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLP 457
Score = 58.5 bits (140), Expect = 3e-08
Identities = 54/209 (25%), Positives = 87/209 (41%), Gaps = 33/209 (15%)
Query: 738 HYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWT-----RQNALTQNPKRSPNTGPP 792
HYT S N ++ ++ C TQD D+ DW AL + +P +G
Sbjct: 1431 HYTSTTGSCNFETSSGNWTTA--CSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQ- 1487
Query: 793 TDISGTPEGYYMFIETSRPRELGDRARLV-SPLYNASAKFYCVSFFYHMYGKHIGSLNLL 851
+++++ +S +E G AR+ S + AS V F+++M + L
Sbjct: 1488 ---------HFLYVNSSGSKE-GSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGI-LK 1536
Query: 852 VRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTL 911
V + + L+ WS+ GNK W VP+S + PF++ FE IA+DD++
Sbjct: 1537 VYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISF 1596
Query: 912 KKGECPRKQTDPNKVVVMPGSGAPCQSSP 940
EC + G P Q SP
Sbjct: 1597 TP-EC------------VTGGPVPVQPSP 1612
Score = 32.7 bits (73), Expect = 1.7
Identities = 14/52 (26%), Positives = 30/52 (57%)
Query: 802 YYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVR 853
++M++E + GD+A S ++ S+ +SF+Y + K GS+ +L++
Sbjct: 1264 HFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFISAKATGSIQILIK 1315
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 120 bits (302), Expect = 5e-27
Identities = 160/708 (22%), Positives = 268/708 (37%), Gaps = 78/708 (11%)
Query: 58 LQCLVTGHPRPQVRWTKTAGSAS-DKFQETSVFNETLRIERIARTQ-GGRYYCKAENGVG 115
L C V G+P P RW + + S+ + T I + + G Y C A N VG
Sbjct: 121 LNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVG 180
Query: 116 VPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPAR-FIWKRGSD 174
+ + YL VS G + V L C+ + P + W
Sbjct: 181 SILSREATLQFAYLGNFSGRTRSAVSVREG-----QGVVLMCSPPPHSPEIIYSWVFNEF 235
Query: 175 TLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQV--SVRNVCGI-PDKAITF 231
++D+ I + ET L + ++ D SY C V +V N + P +T
Sbjct: 236 PSFVAEDSRRFISQ------ETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTL 289
Query: 232 RLTNTTAP--PALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQ 289
R P +++ T+ G V ++C G +P+P + W G +P A +
Sbjct: 290 RNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALG-NPVPTITWMKVNGYIPSKARLR 348
Query: 290 GG--TLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENI 347
L IP+VQ D+G Y C A N+ G N ++ T+ P +++ +
Sbjct: 349 KSQAVLEIPNVQLDDAGIYECRAENSRGK------NSFRGQLQVYTY---PHWVEKLNDT 399
Query: 348 QLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHF 407
QL L A + + TY+W KNG P R+ + V L + +++
Sbjct: 400 QLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEM---------VNGVLMIHNVNQ 450
Query: 408 SDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRG 467
SD G Y C+A + S E+ I + PT ++ + + + V + ++C+ +G
Sbjct: 451 SDAGMYQCLAENKYGAIY-ASAELKILASA--PTFALNQLKKTIIVTKDQEVVIECKPQG 507
Query: 468 KPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPR 527
P+P + W + D+ + + PDG LR+ S+ G Y C+ G
Sbjct: 508 SPKPTISWKKGDR---AVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFG----SA 560
Query: 528 EAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPV 587
E L+V+ P +E + + +G ++L C + + + + W KGQ +
Sbjct: 561 EIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDV-TFYWTLKGQPID---- 615
Query: 588 VPAAAEAPDHAELRLDAVTRDSSGSYECSVSN----DVGSAACLFQVSAKAYSPEFYFDT 643
E H E R + S + + N G C Q +A + S E
Sbjct: 616 ---FEEEGGHFE-----SIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLV 667
Query: 644 PNPTRSHKL-----SKNYSYVLQWTQREPDAVDPVLNYRLSIRQ-LNQHNAVVKAIPVRR 697
P + + L W+ D P+ +Y L R + VK +P
Sbjct: 668 RGPPGPPGIVIVEEITESTATLSWSP-AADNHSPISSYNLQARSPFSLGWQTVKTVP--E 724
Query: 698 VEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMA--SRIIHYTEPI 743
+ G + + DL YE R+ G GD + SR+I E +
Sbjct: 725 IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAV 772
Score = 70.5 bits (171), Expect = 7e-12
Identities = 77/334 (23%), Positives = 126/334 (37%), Gaps = 36/334 (10%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYC 108
T +G T+ ++C G+P P + W K G K L I + G Y C
Sbjct: 311 TAAKGTTVKMECFALGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYEC 369
Query: 109 KAENGVGVPAIKSIRVDVQYLDEP--MLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPAR 166
+AEN G S R +Q P + ++ T D E C P
Sbjct: 370 RAENSRGK---NSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWE------CKATGKPRPT 420
Query: 167 FIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPD 226
+ W + NGV + + VL + N+ D Y C N G
Sbjct: 421 YRWLK----------NGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQC--LAENKYGAIY 468
Query: 227 KAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG- 285
+ ++ +AP + +T++V + V ++C G P P + W G +
Sbjct: 469 ASAELKIL-ASAPTFALNQLKKTIIVTKDQEVVIEC-KPQGSPKPTISWKKGDRAVRENK 526
Query: 286 --ALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKE 343
A+ G+L I + D G Y C N G+ A+ +L V+ + ++TP K
Sbjct: 527 RIAILPDGSLRILNASKSDEGKYVCRGENVFGS-AEIIASLSVK--EPTRIELTP---KR 580
Query: 344 SENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKP 377
+E + +G+ + L+C VT+ W G+P
Sbjct: 581 TE-LTVGESIVLNCKAIHDASLDVTFYWTLKGQP 613
Score = 60.5 bits (145), Expect = 7e-09
Identities = 114/528 (21%), Positives = 180/528 (34%), Gaps = 81/528 (15%)
Query: 128 YLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIY 187
++ EP + T SD EK V L C V NP + W R + D +
Sbjct: 101 FVQEPDDIIFPTDSD-------EKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI 153
Query: 188 EPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFR---LTNTTAPPALKL 244
+ + K D Y C ++ V I + T + L N + +
Sbjct: 154 DGTFIISNPSEAK-------DSGHYQC-LATNTVGSILSREATLQFAYLGNFSGRTRSAV 205
Query: 245 SVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG------ALAQGGTLSIPSV 298
SV E G+ V + C P W P + + G L I V
Sbjct: 206 SVRE------GQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKV 259
Query: 299 QARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCH 358
Q D G Y C N V N R + T + ++ + + K+ H
Sbjct: 260 QTSDVGSYICLVKNTVTN---------ARVLSPPT-----PLTLRNDGVMGEYEPKIEVH 305
Query: 359 ----VDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSS---LELIDLHFSDYG 411
V A V + F G P + V P + S LE+ ++ D G
Sbjct: 306 FPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAG 365
Query: 412 TYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRP 471
Y C A S + T P + + GSP +C+ GKPRP
Sbjct: 366 IYECRAENSRG---KNSFRGQLQVYTYPHWVEKLND---TQLDSGSPLRWECKATGKPRP 419
Query: 472 PVLWSRVDKEAALLPSGLPLE-----ETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRP 526
W L +G+PL E +G L + V++ +G Y+C N +
Sbjct: 420 TYRW---------LKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAE--NKYGAIY 468
Query: 527 REAQVQLNVQFPP-EVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPP 585
A++++ P + + + + V++ C +GSP+ S W+ + +
Sbjct: 469 ASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK-PQGSPKPTIS--WKKGDRAVREN 525
Query: 586 PVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
+ A PD LR+ ++ G Y C N GSA + +S K
Sbjct: 526 KRI---AILPD-GSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVK 569
Score = 46.2 bits (108), Expect = 1e-04
Identities = 46/233 (19%), Positives = 95/233 (40%), Gaps = 27/233 (11%)
Query: 21 VYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSAS 80
+YA A+ +I+ + + N ++ + + ++++C G P+P + W K +
Sbjct: 467 IYASAELKILASAPTFAL---NQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVR 523
Query: 81 DKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTV 140
+ + + + +LRI +++ G+Y C+ EN G I + + V+ LT +T
Sbjct: 524 ENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIA-SLSVKEPTRIELTPKRTE 582
Query: 141 SDVRGNFYQEKTVFLRCTV--NSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKV 198
V +++ L C +++ F W + ++ G +E + Q +
Sbjct: 583 LTV------GESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGG--HFESIRAQASSAD 634
Query: 199 LKLKNLRPQDYASYTCQVS-------------VRNVCGIPDKAITFRLTNTTA 238
L ++N+ Y C+V VR G P I +T +TA
Sbjct: 635 LMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTA 687
Score = 36.2 bits (82), Expect = 0.15
Identities = 56/199 (28%), Positives = 76/199 (38%), Gaps = 26/199 (13%)
Query: 439 PPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSR----VDKEAALLPSGLPLEET 494
P + P T + L CEVRG P P W R +D E+ S +
Sbjct: 99 PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI----- 153
Query: 495 PDGKLRLERVSRDM-SGTYRCQTARYNGFNVRPREAQVQLNV--QFPPEVEPSSQDVRQA 551
DG + S SG Y+C G ++ REA +Q F S+ VR+
Sbjct: 154 -DGTFIISNPSEAKDSGHYQCLATNTVG-SILSREATLQFAYLGNFSGRTR-SAVSVRE- 209
Query: 552 LGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAE---APDHAELRLDAVTRD 608
G+ V+L CS SP+ I S W F P V + + + L + V
Sbjct: 210 -GQGVVLMCSPPPHSPEIIYS--WVFN----EFPSFVAEDSRRFISQETGNLYISKVQTS 262
Query: 609 SSGSYECSVSNDVGSAACL 627
GSY C V N V +A L
Sbjct: 263 DVGSYICLVKNTVTNARVL 281
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 120 bits (302), Expect = 5e-27
Identities = 160/708 (22%), Positives = 268/708 (37%), Gaps = 78/708 (11%)
Query: 58 LQCLVTGHPRPQVRWTKTAGSAS-DKFQETSVFNETLRIERIARTQ-GGRYYCKAENGVG 115
L C V G+P P RW + + S+ + T I + + G Y C A N VG
Sbjct: 47 LNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVG 106
Query: 116 VPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPAR-FIWKRGSD 174
+ + YL VS G + V L C+ + P + W
Sbjct: 107 SILSREATLQFAYLGNFSGRTRSAVSVREG-----QGVVLMCSPPPHSPEIIYSWVFNEF 161
Query: 175 TLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQV--SVRNVCGI-PDKAITF 231
++D+ I + ET L + ++ D SY C V +V N + P +T
Sbjct: 162 PSFVAEDSRRFISQ------ETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTL 215
Query: 232 RLTNTTAP--PALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQ 289
R P +++ T+ G V ++C G +P+P + W G +P A +
Sbjct: 216 RNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALG-NPVPTITWMKVNGYIPSKARLR 274
Query: 290 GG--TLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENI 347
L IP+VQ D+G Y C A N+ G N ++ T+ P +++ +
Sbjct: 275 KSQAVLEIPNVQLDDAGIYECRAENSRGK------NSFRGQLQVYTY---PHWVEKLNDT 325
Query: 348 QLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHF 407
QL L A + + TY+W KNG P R+ + V L + +++
Sbjct: 326 QLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEM---------VNGVLMIHNVNQ 376
Query: 408 SDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRG 467
SD G Y C+A + S E+ I + PT ++ + + + V + ++C+ +G
Sbjct: 377 SDAGMYQCLAENKYGAIY-ASAELKILASA--PTFALNQLKKTIIVTKDQEVVIECKPQG 433
Query: 468 KPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPR 527
P+P + W + D+ + + PDG LR+ S+ G Y C+ G
Sbjct: 434 SPKPTISWKKGDR---AVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFG----SA 486
Query: 528 EAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPV 587
E L+V+ P +E + + +G ++L C + + + + W KGQ +
Sbjct: 487 EIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDV-TFYWTLKGQPID---- 541
Query: 588 VPAAAEAPDHAELRLDAVTRDSSGSYECSVSN----DVGSAACLFQVSAKAYSPEFYFDT 643
E H E R + S + + N G C Q +A + S E
Sbjct: 542 ---FEEEGGHFE-----SIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLV 593
Query: 644 PNPTRSHKL-----SKNYSYVLQWTQREPDAVDPVLNYRLSIRQ-LNQHNAVVKAIPVRR 697
P + + L W+ D P+ +Y L R + VK +P
Sbjct: 594 RGPPGPPGIVIVEEITESTATLSWSP-AADNHSPISSYNLQARSPFSLGWQTVKTVP--E 650
Query: 698 VEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMA--SRIIHYTEPI 743
+ G + + DL YE R+ G GD + SR+I E +
Sbjct: 651 IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAV 698
Score = 70.5 bits (171), Expect = 7e-12
Identities = 77/334 (23%), Positives = 126/334 (37%), Gaps = 36/334 (10%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYC 108
T +G T+ ++C G+P P + W K G K L I + G Y C
Sbjct: 237 TAAKGTTVKMECFALGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYEC 295
Query: 109 KAENGVGVPAIKSIRVDVQYLDEP--MLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPAR 166
+AEN G S R +Q P + ++ T D E C P
Sbjct: 296 RAENSRGK---NSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWE------CKATGKPRPT 346
Query: 167 FIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPD 226
+ W + NGV + + VL + N+ D Y C N G
Sbjct: 347 YRWLK----------NGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQC--LAENKYGAIY 394
Query: 227 KAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG- 285
+ ++ +AP + +T++V + V ++C G P P + W G +
Sbjct: 395 ASAELKIL-ASAPTFALNQLKKTIIVTKDQEVVIEC-KPQGSPKPTISWKKGDRAVRENK 452
Query: 286 --ALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKE 343
A+ G+L I + D G Y C N G+ A+ +L V+ + ++TP K
Sbjct: 453 RIAILPDGSLRILNASKSDEGKYVCRGENVFGS-AEIIASLSVK--EPTRIELTP---KR 506
Query: 344 SENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKP 377
+E + +G+ + L+C VT+ W G+P
Sbjct: 507 TE-LTVGESIVLNCKAIHDASLDVTFYWTLKGQP 539
Score = 60.5 bits (145), Expect = 7e-09
Identities = 114/528 (21%), Positives = 180/528 (34%), Gaps = 81/528 (15%)
Query: 128 YLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIY 187
++ EP + T SD EK V L C V NP + W R + D +
Sbjct: 27 FVQEPDDIIFPTDSD-------EKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI 79
Query: 188 EPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFR---LTNTTAPPALKL 244
+ + K D Y C ++ V I + T + L N + +
Sbjct: 80 DGTFIISNPSEAK-------DSGHYQC-LATNTVGSILSREATLQFAYLGNFSGRTRSAV 131
Query: 245 SVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG------ALAQGGTLSIPSV 298
SV E G+ V + C P W P + + G L I V
Sbjct: 132 SVRE------GQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKV 185
Query: 299 QARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCH 358
Q D G Y C N V N R + T + ++ + + K+ H
Sbjct: 186 QTSDVGSYICLVKNTVTN---------ARVLSPPT-----PLTLRNDGVMGEYEPKIEVH 231
Query: 359 ----VDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSS---LELIDLHFSDYG 411
V A V + F G P + V P + S LE+ ++ D G
Sbjct: 232 FPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAG 291
Query: 412 TYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRP 471
Y C A S + T P + + GSP +C+ GKPRP
Sbjct: 292 IYECRAENSRG---KNSFRGQLQVYTYPHWVEKLND---TQLDSGSPLRWECKATGKPRP 345
Query: 472 PVLWSRVDKEAALLPSGLPLE-----ETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRP 526
W L +G+PL E +G L + V++ +G Y+C N +
Sbjct: 346 TYRW---------LKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAE--NKYGAIY 394
Query: 527 REAQVQLNVQFPP-EVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPP 585
A++++ P + + + + V++ C +GSP+ S W+ + +
Sbjct: 395 ASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK-PQGSPKPTIS--WKKGDRAVREN 451
Query: 586 PVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
+ A PD LR+ ++ G Y C N GSA + +S K
Sbjct: 452 KRI---AILPD-GSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVK 495
Score = 46.2 bits (108), Expect = 1e-04
Identities = 46/233 (19%), Positives = 95/233 (40%), Gaps = 27/233 (11%)
Query: 21 VYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSAS 80
+YA A+ +I+ + + N ++ + + ++++C G P+P + W K +
Sbjct: 393 IYASAELKILASAPTFAL---NQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVR 449
Query: 81 DKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTV 140
+ + + + +LRI +++ G+Y C+ EN G I + + V+ LT +T
Sbjct: 450 ENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIA-SLSVKEPTRIELTPKRTE 508
Query: 141 SDVRGNFYQEKTVFLRCTV--NSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKV 198
V +++ L C +++ F W + ++ G +E + Q +
Sbjct: 509 LTV------GESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGG--HFESIRAQASSAD 560
Query: 199 LKLKNLRPQDYASYTCQVS-------------VRNVCGIPDKAITFRLTNTTA 238
L ++N+ Y C+V VR G P I +T +TA
Sbjct: 561 LMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTA 613
Score = 36.2 bits (82), Expect = 0.15
Identities = 56/199 (28%), Positives = 76/199 (38%), Gaps = 26/199 (13%)
Query: 439 PPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSR----VDKEAALLPSGLPLEET 494
P + P T + L CEVRG P P W R +D E+ S +
Sbjct: 25 PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI----- 79
Query: 495 PDGKLRLERVSRDM-SGTYRCQTARYNGFNVRPREAQVQLNV--QFPPEVEPSSQDVRQA 551
DG + S SG Y+C G ++ REA +Q F S+ VR+
Sbjct: 80 -DGTFIISNPSEAKDSGHYQCLATNTVG-SILSREATLQFAYLGNFSGRTR-SAVSVRE- 135
Query: 552 LGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAE---APDHAELRLDAVTRD 608
G+ V+L CS SP+ I S W F P V + + + L + V
Sbjct: 136 -GQGVVLMCSPPPHSPEIIYS--WVFN----EFPSFVAEDSRRFISQETGNLYISKVQTS 188
Query: 609 SSGSYECSVSNDVGSAACL 627
GSY C V N V +A L
Sbjct: 189 DVGSYICLVKNTVTNARVL 207
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 120 bits (300), Expect = 8e-27
Identities = 157/703 (22%), Positives = 258/703 (36%), Gaps = 82/703 (11%)
Query: 52 EGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFN--ETLRIERIARTQGGRYYCK 109
E + L C G+P P RW + N + I G Y C
Sbjct: 42 EDKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCF 101
Query: 110 AENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPAR--- 166
A N +G + ++ YL+ + TVS G + V L C PP
Sbjct: 102 ATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREG-----QGVVLLC----GPPPHSGE 152
Query: 167 --FIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVS--VRN-- 220
+ W + + + V+ + ET L + + P D +YTC V+ V N
Sbjct: 153 LSYAW------IFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTNAR 206
Query: 221 VCGIPDKAITFRLTNTTAP--PALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHG 278
V G P + R P +++ ETL G V ++C G +P+PQ+ W
Sbjct: 207 VLGSPTPLV-LRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALG-NPIPQINWRRS 264
Query: 279 PGPLPLGALAQ----GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATF 334
G LP + + G L IP+ Q D+G Y C A N+ G + T+
Sbjct: 265 DG-LPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARG---------RLTY 314
Query: 335 QITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELP 394
P ++ +++++ + L A + K +Y+W KNG + +R +
Sbjct: 315 YAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQIENG----- 369
Query: 395 AVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVR 454
+L + +L +D G + C+A V S E+ + + P S + +V V+
Sbjct: 370 ----ALTISNLSVTDSGMFQCIAENKHGLVYS-SAELKVVASA--PDFSKNPMKKLVQVQ 422
Query: 455 EGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRC 514
GS L C+ R PR W + D + + DG L++ V++ +GTY C
Sbjct: 423 VGSLVSLDCKPRASPRALSSWKKGD---VSVQEHERISLLNDGGLKIANVTKADAGTYTC 479
Query: 515 QTARYNGFNVRPREAQVQLNVQFPPEV--EPSSQDVRQALGRPVLLRCSLLRGSPQRIAS 572
G L V P + PS+ DV ++G V+L C ++ P
Sbjct: 480 MAENQFG----KANGTTHLVVTEPTRITLAPSNMDV--SVGESVILPCQ-VQHDPLLDII 532
Query: 573 AVWRFKGQL--LPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQV 630
W F G L +L + + SG Y C V V S + +
Sbjct: 533 FTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADL 592
Query: 631 SAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQRE-PDAVDPVLNYRLSIR-QLNQHNA 688
+ +P P + K+ + Q + +E D PV++Y + R +
Sbjct: 593 IVRG--------SPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQ 644
Query: 689 VVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGD 731
V +P V G+ + +L YE R+ G G+
Sbjct: 645 TVTTVP--EVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGE 685
Score = 37.4 bits (85), Expect = 0.067
Identities = 50/234 (21%), Positives = 88/234 (37%), Gaps = 30/234 (12%)
Query: 21 VYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSAS 80
VY+ A+ ++V + N +++ ++ G + L C PR W K S
Sbjct: 395 VYSSAELKVVASAPDF---SKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQ 451
Query: 81 DKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEP-MLTVHQT 139
+ + + + + L+I + + G Y C AEN G K+ + EP +T+ +
Sbjct: 452 EHERISLLNDGGLKIANVTKADAGTYTCMAENQFG----KANGTTHLVVTEPTRITLAPS 507
Query: 140 VSDVRGNFYQEKTVFLRCTVNSNP--PARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETK 197
DV ++V L C V +P F W +D + G+
Sbjct: 508 NMDVSVG----ESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGD-- 561
Query: 198 VLKLKNLRPQDYASYTCQVS-------------VRNVCGIPDKAITFRLTNTTA 238
L ++N++ + Y C V VR G P+ +T+TTA
Sbjct: 562 -LMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGSPGPPENVKVDEITDTTA 614
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor
[Homo sapiens]
Length = 1070
Score = 117 bits (294), Expect = 4e-26
Identities = 145/572 (25%), Positives = 218/572 (38%), Gaps = 61/572 (10%)
Query: 58 LQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE--TLRIERIARTQGGRYYCKAENGVG 115
L+C + GHPRP +W + SD +V ++ L + G Y C A + G
Sbjct: 148 LRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFG 207
Query: 116 VPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDT 175
A S + DE V DV Y+E C ++ PP W +T
Sbjct: 208 -QACSSQNFTLSIADESFARVVLAPQDVVVARYEE--AMFHCQFSAQPPPSLQWLFEDET 264
Query: 176 LSHSQDNGVDIYE-PLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLT 234
++ + ++ G L L +RP++ Y C + I +A T L
Sbjct: 265 PITNRSRPPHLRRATVFANGS---LLLTQVRPRNAGIYRCIGQGQRGPPIILEA-TLHLA 320
Query: 235 NTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPL-GALAQ-GGT 292
P E V G V CL G P P + W H LP G + Q G
Sbjct: 321 EIEDMPLF-----EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHE 375
Query: 293 LSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQL--G 350
L + ++ D+G Y C A N G ++ VN+ V ++ P +K+ ++ QL G
Sbjct: 376 LVLANIAESDAGVYTCHAANLAGQ-RRQDVNITVATV--------PSWLKKPQDSQLEEG 426
Query: 351 QDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDY 410
+ L C A P K T W++N R V +N +L + + D
Sbjct: 427 KPGYLDCLTQATP--KPTVVWYRNQMLISEDSRFEVFKN--------GTLRINSVEVYDG 476
Query: 411 GTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPR 470
Y CM+S P S+E + + P + + A + C G+ +
Sbjct: 477 TWYRCMSSTPAG-----SIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREK 531
Query: 471 PPVLWSRVDKEAALLPSGLPLEETPD-GKLRLERVSRDMSGTYRCQTARYNGFNVRPREA 529
P + W R D S LP T + G L RV+RD +G Y C + +R A
Sbjct: 532 PTIKWERAD------GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIR---A 582
Query: 530 QVQLNVQ--FPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPV 587
VQL V +VEP V Q G LL+C +G P+ + W+ K ++L P +
Sbjct: 583 HVQLTVAVFITFKVEPERTTVYQ--GHTALLQCE-AQGDPKPLIQ--WKGKDRILDPTKL 637
Query: 588 VPAAAEAPDHAELRLDAVTRDSSGSYECSVSN 619
P + L + V + SG Y C N
Sbjct: 638 GP-RMHIFQNGSLVIHDVAPEDSGRYTCIAGN 668
Score = 82.8 bits (203), Expect = 1e-15
Identities = 129/585 (22%), Positives = 212/585 (36%), Gaps = 72/585 (12%)
Query: 52 EGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQ-GGRYYCKA 110
+G +L+C V V W D + +L + R Q G + C A
Sbjct: 45 QGRRALLRCEVEAPGPVHVYWLLDGAPVQDT-ERRFAQGSSLSFAAVDRLQDSGTFQCVA 103
Query: 111 ENGVGVPAIKSIRV--DVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFI 168
+ V +S ++++++ + + S+ + V LRC ++ +P +
Sbjct: 104 RDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAE--IQPQTQVTLRCHIDGHPRPTYQ 161
Query: 169 WKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKA 228
W R LS Q N + + L L+ P+ Y+C + G +
Sbjct: 162 WFRDGTPLSDGQSNHT-------VSSKERNLTLRPAGPEHSGLYSC--CAHSAFGQACSS 212
Query: 229 ITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQW----------SHG 278
F L+ A + + +VV E C + P P LQW
Sbjct: 213 QNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFS-AQPPPSLQWLFEDETPITNRSR 271
Query: 279 PGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITP 338
P L + G+L + V+ R++G Y C G P +L ++ A + P
Sbjct: 272 PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPI-----ILEATLHLAEIEDMP 326
Query: 339 DVIKESENIQLGQDLKLSC-HVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVT 397
+ E G + +++C +P+ V W+++ R+ V + E
Sbjct: 327 --LFEPRVFTAGSEERVTCLPPKGLPEPSV---WWEHA-GVRLPTHGRVYQKGHE----- 375
Query: 398 SSLELIDLHFSDYGTYLC-MASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREG 456
L L ++ SD G Y C A+ G D VNI+ TVP + P+ + EG
Sbjct: 376 --LVLANIAESDAGVYTCHAANLAGQRRQD----VNITVATVPSWLKKPQDS---QLEEG 426
Query: 457 SPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQT 516
P L C + P+P V+W R L+ E +G LR+ V YRC +
Sbjct: 427 KPGYLDCLTQATPKPTVVWYR---NQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMS 483
Query: 517 ARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW- 575
+ G QV ++F P +P + + CS + + + W
Sbjct: 484 STPAGSIEAQARVQVLEKLKFTPPPQPQQ---CMEFDKEATVPCS---ATGREKPTIKWE 537
Query: 576 RFKGQLLPPPPVVPAAAEAPDHA-ELRLDAVTRDSSGSYECSVSN 619
R G LP D+A L VTRD +G+Y C SN
Sbjct: 538 RADGSSLP--------EWVTDNAGTLHFARVTRDDAGNYTCIASN 574
Score = 70.5 bits (171), Expect = 7e-12
Identities = 112/497 (22%), Positives = 187/497 (37%), Gaps = 64/497 (12%)
Query: 57 MLQCLVTGHPRPQVRWTK------TAGSASDKFQETSVF-NETLRIERIARTQGGRYYCK 109
M C + P P ++W T S + +VF N +L + ++ G Y C
Sbjct: 243 MFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCI 302
Query: 110 AENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIW 169
+ G P I + + +++ L + F + C P +W
Sbjct: 303 GQGQRGPPIILEATLHLAEIEDMPLFEPRV-------FTAGSEERVTCLPPKGLPEPSVW 355
Query: 170 --KRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDK 227
G +H + +Y +G VL N+ D YTC + N+ G +
Sbjct: 356 WEHAGVRLPTHGR---------VYQKGHELVLA--NIAESDAGVYTCHAA--NLAG--QR 400
Query: 228 AITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGA- 286
+T T P LK + L G+ + CL T P P + W + +
Sbjct: 401 RQDVNITVATVPSWLKKPQDSQL--EEGKPGYLDCL-TQATPKPTVVWYRNQMLISEDSR 457
Query: 287 --LAQGGTLSIPSVQARDSGYYNCTATNNVGN-PAKKTVNLLVRSMKNATFQITPDVIKE 343
+ + GTL I SV+ D +Y C ++ G+ A+ V +L + + TP +
Sbjct: 458 FEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEK------LKFTPPP-QP 510
Query: 344 SENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELI 403
+ ++ ++ + C A +EK T +W + S VT N +L
Sbjct: 511 QQCMEFDKEATVPC--SATGREKPTIKW---ERADGSSLPEWVTDN-------AGTLHFA 558
Query: 404 DLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQC 463
+ D G Y C+AS P + V + TV I+ TV +G A LQC
Sbjct: 559 RVTRDDAGNYTCIAS--NGPQGQIRAHVQL---TVAVFITFKVEPERTTVYQGHTALLQC 613
Query: 464 EVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFN 523
E +G P+P + W D+ G + +G L + V+ + SG Y C N N
Sbjct: 614 EAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAG--NSCN 671
Query: 524 VRPREAQVQLNVQFPPE 540
++ EA + + + PE
Sbjct: 672 IKHTEAPLYVVDKPVPE 688
Score = 53.9 bits (128), Expect = 7e-07
Identities = 69/270 (25%), Positives = 95/270 (35%), Gaps = 29/270 (10%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCK 109
+ EG L CL P+P V W + S+ + N TLRI + G Y C
Sbjct: 423 LEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCM 482
Query: 110 AENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIW 169
+ G +I++ + VQ L++ T F +E TV T P + W
Sbjct: 483 SSTPAG--SIEA-QARVQVLEKLKFTPPPQPQQCM-EFDKEATVPCSATGREKPTIK--W 536
Query: 170 KRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAI 229
+R + P + L + D +YTC S P I
Sbjct: 537 ERADGSSL-----------PEWVTDNAGTLHFARVTRDDAGNYTCIAS-----NGPQGQI 580
Query: 230 TFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGP---GPLPLGA 286
+ T A E V G +QC GDP P +QW P LG
Sbjct: 581 RAHVQLTVAVFITFKVEPERTTVYQGHTALLQC-EAQGDPKPLIQWKGKDRILDPTKLGP 639
Query: 287 ---LAQGGTLSIPSVQARDSGYYNCTATNN 313
+ Q G+L I V DSG Y C A N+
Sbjct: 640 RMHIFQNGSLVIHDVAPEDSGRYTCIAGNS 669
Score = 37.7 bits (86), Expect = 0.052
Identities = 27/93 (29%), Positives = 39/93 (41%), Gaps = 16/93 (17%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRW--------TKTAGSASDKFQETSVFNETLRIERIAR 100
T+ +G T +LQC G P+P ++W G FQ N +L I +A
Sbjct: 602 TVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQ-----NGSLVIHDVAP 656
Query: 101 TQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPM 133
GRY C A N IK + +D+P+
Sbjct: 657 EDSGRYTCIAGNSCN---IKHTEAPLYVVDKPV 686
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 117 bits (293), Expect = 5e-26
Identities = 170/693 (24%), Positives = 272/693 (39%), Gaps = 114/693 (16%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTAG--SASDKFQETSVFNETLRIERIARTQGGRYYCKA 110
G + L C GHP P RW K S +FQ+T L IE I + G Y C+
Sbjct: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVT---GLLIENIRPSDSGSYVCEV 295
Query: 111 ENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWK 170
N G + + Y+ +P+ T+S + V L C+V W
Sbjct: 296 SNRYGTAKV----IGRLYVKQPLKA---TISPRKVKSSVGSQVSLSCSVTGTEDQELSWY 348
Query: 171 RGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAIT 230
R + L+ ++ + T + L + ++ D +Y C V + +
Sbjct: 349 RNGEILNPGKNVRI-------TGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVV 401
Query: 231 FRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGA---- 286
P + + +E VV+P E V++ C + G PLP + W+ P+ G
Sbjct: 402 LE----DGTPKIISAFSEK-VVSPAEPVSLMCNVKG-TPLPTITWTLDDDPILKGGSHRI 455
Query: 287 ----LAQGGTLS---IPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPD 339
++G +S I S Q RD G Y CTA N+ G +L ++ N P
Sbjct: 456 SQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAG-------VVLYQARINVR---GPA 505
Query: 340 VIKESENIQ--LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVT 397
I+ +NI G+D + C V P + +W+KN + R + N+
Sbjct: 506 SIRPMKNITAIAGRDTYIHCRVIGYPYYSI--KWYKNSNLLPFNHRQVAFENN------- 556
Query: 398 SSLELIDLHFS-DYGTYLCMASFPGAPVPDLSVEVNISSETVPPTI---SVPK---GRAV 450
+L+L D+ D G Y C SV V + VPP I P+ G+ V
Sbjct: 557 GTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVK---VPPFIQPFEFPRFSIGQRV 613
Query: 451 ----VTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSR 506
V V P + + G+P P L +D ++ T LR+ +S
Sbjct: 614 FIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDN----------IDFT--SSLRISNLSL 661
Query: 507 DMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGS 566
+G Y C AR V E Q QL V+ PP+ +D G+ V+L CS G
Sbjct: 662 MHNGNYTC-IARNEAAAV---EHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCS-AEGY 716
Query: 567 PQRIASAVWRF-KGQLLP--PPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGS 623
P + + VW+F KG +P P + + + L + V + SG Y C VSNDVG+
Sbjct: 717 P--VPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGA 774
Query: 624 AACLFQVSAKAY----SPEFYFDTPNPTRSHKLSK---------NYSYVLQWTQREPDAV 670
VS Y P PN T + + K +++W ++E +
Sbjct: 775 -----DVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRW-EKEDRII 828
Query: 671 DP-VLNYRLSIRQLNQH-NAVVKAIPVRRVEKG 701
+P + Y +S +++ + + ++ +P R + G
Sbjct: 829 NPEMARYLVSTKEVGEEVISTLQILPTVREDSG 861
Score = 88.6 bits (218), Expect = 3e-17
Identities = 143/721 (19%), Positives = 267/721 (37%), Gaps = 90/721 (12%)
Query: 43 ISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAG--SASDKFQETSVFNETLRIERIAR 100
IS R G + L C VTG ++ W + + + T + +E L ++ + +
Sbjct: 318 ISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVK 377
Query: 101 TQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQE-----KTVFL 155
+ GG Y C ++ ++ Q D + + + F ++ + V L
Sbjct: 378 SDGGAYQC---------FVRKDKLSAQ--DYVQVVLEDGTPKIISAFSEKVVSPAEPVSL 426
Query: 156 RCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGE-TKVLKLKNLRPQDYASYTC 214
C V P W D + + + + + ++G L + + + +D Y C
Sbjct: 427 MCNVKGTPLPTITWTLDDDPILKGGSHRIS--QMITSEGNVVSYLNISSSQVRDGGVYRC 484
Query: 215 QVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQ 274
+ N G+ + N P +++ N T + G + + C + G P ++
Sbjct: 485 --TANNSAGV---VLYQARINVRGPASIRPMKNITAIA--GRDTYIHCRVI-GYPYYSIK 536
Query: 275 WSHGPGPLPLG----ALAQGGTLSIPSVQAR-DSGYYNCTATNNVGNPAKKTVNLLVRSM 329
W LP A GTL + VQ D G Y C ++V++ V+
Sbjct: 537 WYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVK-- 594
Query: 330 KNATFQITPDVIK--ESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVT 387
P I+ E +GQ + + C V +T W K+G+P S + +
Sbjct: 595 -------VPPFIQPFEFPRFSIGQRVFIPC-VVVSGDLPITITWQKDGRPIPGSLGVTID 646
Query: 388 RNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISV-PK 446
D TSSL + +L G Y C+A A V S + VPP V P+
Sbjct: 647 NID-----FTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLI----VRVPPKFVVQPR 697
Query: 447 GRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLP------LEETPDGKLR 500
+ + G L C G P P ++W + A +P P ++ +G L
Sbjct: 698 DQDGI---YGKAVILNCSAEGYPVPTIVWK--FSKGAGVPQFQPIALNGRIQVLSNGSLL 752
Query: 501 LERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRC 560
++ V + SG Y C+ + G +V + L V+ P + G+ + C
Sbjct: 753 IKHVVEEDSGYYLCKVSNDVGADV---SKSMYLTVKIPAMITSYPNTTLATQGQKKEMSC 809
Query: 561 SLLRGSPQRIASAVWRFKGQLLPPPPV--VPAAAEAPDH--AELRLDAVTRDSSGSYECS 616
+ P + W + +++ P + + E + + L++ R+ SG + C
Sbjct: 810 TAHGEKPIIVR---WEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCH 866
Query: 617 VSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSH-KLSKNYSYVLQWTQREPDAVDPVLN 675
N G + Q++ + + P+P K K + L+WT D P+
Sbjct: 867 AINSYGEDRGIIQLTVQ--------EPPDPPEIEIKDVKARTITLRWTMGF-DGNSPITG 917
Query: 676 YRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASR 735
Y + + N+ ++ A + V QL + D+ +Y +R+ G + ++
Sbjct: 918 YDIECK--NKSDSWDSAQRTKDVSP-QLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNE 974
Query: 736 I 736
+
Sbjct: 975 L 975
Score = 63.2 bits (152), Expect = 1e-09
Identities = 102/455 (22%), Positives = 175/455 (38%), Gaps = 72/455 (15%)
Query: 26 QAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQE 85
QA+I G A + NI T G + C V G+P ++W K + ++
Sbjct: 496 QARINVRGPASIRPMKNI-----TAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQ 550
Query: 86 TSVFNE-TLRIERIAR-TQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDV 143
+ N TL++ + + G Y C + +S+ V V+ P + +
Sbjct: 551 VAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKV--PPFIQPFEFP--- 605
Query: 144 RGNFYQEKTVFLRCTVNSNP-PARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLK 202
F + VF+ C V S P W++ + S +D + T L++
Sbjct: 606 --RFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNID------FTSSLRIS 657
Query: 203 NLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNP-------G 255
NL +YTC ++ + ++ L + V VV P G
Sbjct: 658 NLSLMHNGNYTC-IARNEAAAVEHQS------------QLIVRVPPKFVVQPRDQDGIYG 704
Query: 256 ENVTVQCLLTGGDPLPQLQWSHGPG-------PLPLGALAQ---GGTLSIPSVQARDSGY 305
+ V + C G P+P + W G P+ L Q G+L I V DSGY
Sbjct: 705 KAVILNCSAEGY-PVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGY 763
Query: 306 YNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQL---GQDLKLSCHVDAV 362
Y C +N+VG K++ L V+ P +I N L GQ ++SC A
Sbjct: 764 YLCKVSNDVGADVSKSMYLTVK---------IPAMITSYPNTTLATQGQKKEMSC--TAH 812
Query: 363 PQEKVTYQWFKNGK--PARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP 420
++ + +W K + M++ L+ T+ E V S+L+++ D G + C A
Sbjct: 813 GEKPIIVRWEKEDRIINPEMARYLVSTKEVGE--EVISTLQILPTVREDSGFFSCHAINS 870
Query: 421 GAPVPDLSVEVNISSETVPPTISVPKGRA-VVTVR 454
+ +++ + PP I + +A +T+R
Sbjct: 871 YGEDRGI-IQLTVQEPPDPPEIEIKDVKARTITLR 904
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 8/84 (9%)
Query: 240 PALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQG-------GT 292
PA L+ + T+ +++ + C G DP P ++W P G G+
Sbjct: 1285 PARILTFSGTVTTPWMKDIVLPCKAVG-DPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGS 1343
Query: 293 LSIPSVQARDSGYYNCTATNNVGN 316
I +V+A DSGYY+C A NN G+
Sbjct: 1344 FIIRTVKAEDSGYYSCIANNNWGS 1367
Score = 36.6 bits (83), Expect = 0.11
Identities = 28/91 (30%), Positives = 40/91 (43%), Gaps = 6/91 (6%)
Query: 56 LMLQCLVTGHPRPQVRWTKTAGSASDKFQ---ETSVF-NETLRIERIARTQGGRYYCKAE 111
++L C G P P V+W K + S+F N + I + G Y C A
Sbjct: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIAN 1362
Query: 112 NGVGV-PAIKSIRVDVQYLDEPMLTVHQTVS 141
N G I +++V V D+P LTV +T S
Sbjct: 1363 NNWGSDEIILNLQVQVP-PDQPRLTVSKTTS 1392
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 116 bits (290), Expect = 1e-25
Identities = 143/611 (23%), Positives = 231/611 (37%), Gaps = 67/611 (10%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTKTAG-SASDKFQETSVFNE--TLRIERIARTQGGR 105
T+ G+T L+C V G P V W K S + + S +N+ +LRI + R G
Sbjct: 5714 TVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGT 5773
Query: 106 YYCKAENGVGVPAIKSIRVDVQYLDEPMLTVH--QTVSDVRGNFYQEKTVFLRCTVNSNP 163
Y + +N VG + ++ VDV P + V G + L C V +
Sbjct: 5774 YTFQVQNNVGKSSCTAV-VDVSDRAVPPSFTRRLKNTGGVLG-----ASCILECKVAGSS 5827
Query: 164 PARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCG 223
P W + Y+ ++ L+L +L D +YTC + NV G
Sbjct: 5828 PISVAWFHEKTKIVSGAK-----YQTTFSD-NVCTLQLNSLDSSDMGNYTCVAA--NVAG 5879
Query: 224 IPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP 283
+ R T P + E L V PG+NVT ++ G P ++ W G L
Sbjct: 5880 SDE----CRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPF-KVNWFRGARELV 5934
Query: 284 LGALAQ------GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQIT 337
G L + ++ SG Y C +NN G A T L V+ +++
Sbjct: 5935 KGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQ-ASCTTRLFVKEPAAFLKRLS 5993
Query: 338 PDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVT 397
++ ++I L S + +P ++ W K+G S++ + + T
Sbjct: 5994 DHSVEPGKSIILE-----STYTGTLP---ISVTWKKDGFNITTSEKCNIVTTEK-----T 6040
Query: 398 SSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVRE-- 455
LE+++ D G Y C +E + +S + VT E
Sbjct: 6041 CILEILNSTKRDAGQYSC------------EIENEAGRDVCGALVSTLEPPYFVTELEPL 6088
Query: 456 ----GSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGT 511
G LQC+V G P V W + D + P L +V+ + SG
Sbjct: 6089 EAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGE 6148
Query: 512 YRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIA 571
Y C+ G ++Q Q PP +D+ Q +G PV L C L +P ++
Sbjct: 6149 YTCKAENSIGTASSKTVFRIQ-ERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVC 6207
Query: 572 SAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVS 631
W G LL + + + A L++ SG Y CS SN +G+A+ +++
Sbjct: 6208 ---WYRDGVLLRDDENLQTSF-VDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLT 6263
Query: 632 AKAYSPEFYFD 642
A+ +FD
Sbjct: 6264 AREPKKSPFFD 6274
Score = 114 bits (285), Expect = 4e-25
Identities = 147/618 (23%), Positives = 253/618 (40%), Gaps = 72/618 (11%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNET---LRIERIARTQGGRYYCK 109
G + ++ G P +V W + A + F +T L + I +Q G Y C
Sbjct: 5907 GKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCV 5966
Query: 110 AENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIW 169
N G A + R+ ++ EP + + +SD + K++ L T P W
Sbjct: 5967 VSNNAG-QASCTTRL---FVKEPAAFLKR-LSD--HSVEPGKSIILESTYTGTLPISVTW 6019
Query: 170 KRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQV---SVRNVCGIPD 226
K+ ++ S+ + T +T +L++ N +D Y+C++ + R+VCG
Sbjct: 6020 KKDGFNITTSEKCNI------VTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGA-- 6071
Query: 227 KAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHG-----PGP 281
L +T PP + E L G++V++QC + G P + W G P P
Sbjct: 6072 ------LVSTLEPPYFVTEL-EPLEAAVGDSVSLQCQVAG-TPEITVSWYKGDTKLRPTP 6123
Query: 282 LPLGALAQG-GTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDV 340
TL V DSG Y C A N++G + KTV + Q+ P
Sbjct: 6124 EYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQER------QLPPSF 6177
Query: 341 IKESENIQ--LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTS 398
++ ++I+ +G + L+C ++ +V W+++G R + L + D +
Sbjct: 6178 ARQLKDIEQTVGLPVTLTCRLNGSAPIQVC--WYRDGVLLRDDENLQTSFVDN-----VA 6230
Query: 399 SLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSP 458
+L+++ S G Y C AS P S + P + + V G
Sbjct: 6231 TLKILQTDLSHSGQYSCSASNPLGTASS-SARLTAREPKKSPFFDIKP--VSIDVIAGES 6287
Query: 459 AELQCEVRGKPRPPVLWSRVDKEAALLPSG----LPLEETPDGKLRLERVSRDMSGTYRC 514
A+ +C V G + WS+ +KE + P G + TP LR+ +V + SG Y C
Sbjct: 6288 ADFECHVTGAQPMRITWSKDNKE--IRPGGNYTITCVGNTPH--LRILKVGKGDSGQYTC 6343
Query: 515 QTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQAL-GRPVLLRCSLLRGSPQRIASA 573
Q G ++ QL+V+ PP+ + + A G + L C + GSP+ I +
Sbjct: 6344 QATNDVGKDM----CSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKI-SGSPE-IKVS 6397
Query: 574 VWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
+R +L + + A L ++ + + SG Y C N VG A+C ++ K
Sbjct: 6398 WFRNDSELHESWKYNMSFINSV--ALLTINEASAEDSGDYICEAHNGVGDASCSTALTVK 6455
Query: 634 AYSPEFYFDTPNPTRSHK 651
A P + P+P + K
Sbjct: 6456 A--PPVFTQKPSPVGALK 6471
Score = 111 bits (278), Expect = 3e-24
Identities = 150/680 (22%), Positives = 265/680 (38%), Gaps = 71/680 (10%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTKTAGSAS-DKFQETSVFNE--TLRIERIARTQGGR 105
T+ G+ L+C+VTG P +W K S D + N+ +L+I + G
Sbjct: 6655 TVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGL 6714
Query: 106 YYCKAENGVGVP-AIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPP 164
Y + +N VG S+ V + + + + V+ + G +V L C V+ + P
Sbjct: 6715 YSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILG-----ASVVLECRVSGSAP 6769
Query: 165 ARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGI 224
W + + + E + T L L L P D YTC + NV G
Sbjct: 6770 ISVGWFQDGNEIVSGPKCQSSFSENVCT------LNLSLLEPSDTGIYTCVAA--NVAGS 6821
Query: 225 PDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPL 284
+ + + PP+ + +++ V PG ++T ++ G P +++W G L
Sbjct: 6822 DECSAVLTVQE---PPSFE-QTPDSVEVLPGMSLTFTSVIRGTPPF-KVKWFKGSRELVP 6876
Query: 285 GALAQGG------TLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITP 338
G L + VQ +SG Y+C TN+ G+ A T +L V+ + ATF
Sbjct: 6877 GESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGS-ASCTTHLFVK--EPATF---- 6929
Query: 339 DVIKE--SENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAV 396
+K +++ G + L P ++ W K+ S+R +T +
Sbjct: 6930 --VKRLADFSVETGSPIVLEATYTGTP--PISVSWIKDEYLISQSERCSITMTEK----- 6980
Query: 397 TSSLELIDLHFSDYGTYLCM-ASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVRE 455
++ LE+++ DY Y C+ + G + + V V PP P +
Sbjct: 6981 STILEILESTIEDYAQYSCLIENEAGQDICEALVSV-----LEPPYFIEPLEHVEAVI-- 7033
Query: 456 GSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQ 515
G PA LQC+V G P + W + + P+ + L + +V G Y C+
Sbjct: 7034 GEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCK 7093
Query: 516 TARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW 575
G V V + PP +DV + LG PV C + P +++ W
Sbjct: 7094 ADNSVG-AVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVS---W 7149
Query: 576 RFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAY 635
G LL + + + A L++ + G Y CS SN +G+A+ ++ +
Sbjct: 7150 YKDGVLLKDDANLQTSF-VHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEH 7208
Query: 636 SPEFYFDTPNPTRSHKLSKNYSYVLQWTQREP---------DAVDPVLNYRLSIRQLNQH 686
+FD + L ++ ++ T P + P NY+++ L ++
Sbjct: 7209 EVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMT---LVEN 7265
Query: 687 NAVVKAIPVRRVEKGQLLEY 706
A + + V + + GQ Y
Sbjct: 7266 TATLTVLKVGKGDAGQYTCY 7285
Score = 110 bits (276), Expect = 5e-24
Identities = 136/598 (22%), Positives = 221/598 (36%), Gaps = 56/598 (9%)
Query: 48 YTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNET---LRIERIARTQGG 104
+++ G +++L+ TG V W K + + + V E L I + G
Sbjct: 5995 HSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAG 6054
Query: 105 RYYCKAENGVGVPAIKSIRVDVQYLDEP-MLTVHQTVSDVRGNFYQEKTVFLRCTVNSNP 163
+Y C+ EN G ++ V L+ P +T + + G+ +V L+C V P
Sbjct: 6055 QYSCEIENEAGRDVCGAL---VSTLEPPYFVTELEPLEAAVGD-----SVSLQCQVAGTP 6106
Query: 164 PARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCG 223
W +G L + + Y +T L + D YTC+ N G
Sbjct: 6107 EITVSWYKGDTKLRPTPE-----YRTYFTNN-VATLVFNKVNINDSGEYTCKAE--NSIG 6158
Query: 224 IPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHG----- 278
FR+ PP+ + + + G VT+ C L G P+ + G
Sbjct: 6159 TASSKTVFRIQERQLPPSFARQLKD-IEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRD 6217
Query: 279 PGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITP 338
L + TL I SG Y+C+A+N +G A + L R K + F
Sbjct: 6218 DENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGT-ASSSARLTAREPKKSPFF--- 6273
Query: 339 DVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTS 398
D+ S ++ G+ CHV ++T W K+ K R +T T
Sbjct: 6274 DIKPVSIDVIAGESADFECHVTGAQPMRIT--WSKDNKEIRPGGNYTIT-----CVGNTP 6326
Query: 399 SLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVP-PTISVPKGRAVVTVREGS 457
L ++ + D G Y C A+ D+ ++ + +V P V K A ++G
Sbjct: 6327 HLRILKVGKGDSGQYTCQAT------NDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGE 6380
Query: 458 PAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTA 517
+L+C++ G P V W R D E L + S + SG Y C+
Sbjct: 6381 SIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEA- 6439
Query: 518 RYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRF 577
+NG V L V+ PP V G V+L+C + P + VW
Sbjct: 6440 -HNG--VGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEV---VWVK 6493
Query: 578 KGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSS--GSYECSVSNDVGSAACLFQVSAK 633
+ + ++ H + L + ++S G Y C +N+VGS C V K
Sbjct: 6494 DRKQVRNSKKFKITSK---HFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFK 6548
Score = 110 bits (274), Expect = 8e-24
Identities = 135/598 (22%), Positives = 234/598 (39%), Gaps = 65/598 (10%)
Query: 51 REGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNET---LRIERIARTQGGRYY 107
++G+++ L+C ++G P +V W + + ++ F + L I + G Y
Sbjct: 6377 KQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYI 6436
Query: 108 CKAENGVGVPAIKS---IRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPP 164
C+A NGVG + + ++ + +P V ++G+ V L+C ++ PP
Sbjct: 6437 CEAHNGVGDASCSTALTVKAPPVFTQKP-----SPVGALKGS-----DVILQCEISGTPP 6486
Query: 165 ARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGI 224
+W + + +S+ + ++ L + NL D Y C+ +
Sbjct: 6487 FEVVWVKDRKQVRNSKKFKIT------SKHFDTSLHILNLEASDVGEYHCKATNEVGSDT 6540
Query: 225 PDKAITFRLTNTTAPPAL--KLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPL 282
++ F+ PP KLS TL+ G+ V ++ ++ G P+ + W G +
Sbjct: 6541 CSCSVKFK-----EPPRFVKKLSDTSTLI---GDAVELRAIVEGFQPI-SVVWLKDRGEV 6591
Query: 283 -------PLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQ 335
+ + TL + S +A +SG Y C N+ G + + ++ ++ A
Sbjct: 6592 IRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAG---MRECSAVLTVLEPARII 6648
Query: 336 ITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPA 395
P E + G L C V P+ ++ +WFK+G+ + +T +
Sbjct: 6649 EKP----EPMTVTTGNPFALECVVTGTPE--LSAKWFKDGRELSADSKHHITFINK---- 6698
Query: 396 VTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVRE 455
+SL++ SD G Y + +V V++S VPP+ + K + V +
Sbjct: 6699 -VASLKIPCAEMSDKGLYSFEVK-NSVGKSNCTVSVHVSDRIVPPSF-IRKLKDVNAIL- 6754
Query: 456 GSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQ 515
G+ L+C V G V W + E P L L + +G Y C
Sbjct: 6755 GASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCV 6814
Query: 516 TARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW 575
A G + E L VQ PP E + V G + S++RG+P W
Sbjct: 6815 AANVAGSD----ECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFT-SVIRGTPP--FKVKW 6867
Query: 576 RFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
FKG P + EL L V SG Y C V+ND GSA+C + K
Sbjct: 6868 -FKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVK 6924
Score = 105 bits (263), Expect = 2e-22
Identities = 133/613 (21%), Positives = 234/613 (38%), Gaps = 87/613 (14%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE---TLRIERIARTQGGRYYCK 109
G ++ ++C V+G +W K S + V +E +L + + Y CK
Sbjct: 5251 GSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCK 5310
Query: 110 AENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIW 169
N G A I + EP + V R + TV + + PP + W
Sbjct: 5311 VSNVAGDDACSGILT----VKEPPSFL---VKPGRQQAIPDSTVEFKAILKGTPPFKIKW 5363
Query: 170 KRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAI 229
+ L + + +G T L L ++ YTC V+ N G D
Sbjct: 5364 FKDDVELVSGPKCFIGL------EGSTSFLNLYSVDASKTGQYTCHVT--NDVG-SDSCT 5414
Query: 230 TFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP------ 283
T L T PP + + +V G++ ++C + G P ++ W LP
Sbjct: 5415 TMLLV--TEPPKFVKKLEASKIVKAGDSSRLECKIAGS-PEIRVVWFRNEHELPASDKYR 5471
Query: 284 LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKE 343
+ + + + ++ DSG + C A N G+ + T ++V+ + F P +++
Sbjct: 5472 MTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCST-KVIVK--EPPVFSSFPPIVET 5528
Query: 344 SENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELI 403
+N ++ L C + P +V W+K+ + R SK+ + + +S+ ++
Sbjct: 5529 LKNAEVS----LECELSGTPPFEVV--WYKDKRQLRSSKKYKIASKN-----FHTSIHIL 5577
Query: 404 DLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVV------TVREGS 457
++ SD G Y C A + + S+T T+ + + V TV G
Sbjct: 5578 NVDTSDIGEYHCKA------------QNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGE 5625
Query: 458 PAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPD-GKLRLERVSRDMSGTYRCQT 516
PAELQ + G V W + +E + + + L+ + +G Y CQ
Sbjct: 5626 PAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQI 5685
Query: 517 ARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWR 576
G RE L V P + + + +G L C + G+P+ S W
Sbjct: 5686 KNDGGM----RENMATLMVLEPAVIVEKAGPMTVTVGETCTLECKVA-GTPE--LSVEWY 5738
Query: 577 FKGQLLPPPPVVPAAAEAPDH--------AELRLDAVTRDSSGSYECSVSNDVGSAAC-- 626
G+LL + H + LR+ +V R +G+Y V N+VG ++C
Sbjct: 5739 KDGKLL---------TSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTA 5789
Query: 627 LFQVSAKAYSPEF 639
+ VS +A P F
Sbjct: 5790 VVDVSDRAVPPSF 5802
Score = 103 bits (257), Expect = 8e-22
Identities = 127/583 (21%), Positives = 227/583 (38%), Gaps = 54/583 (9%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGS-ASDKFQETSVFNE--TLRIERIARTQGGRY 106
+ E D + L+C+V G P +V+W K ++ S N + RI+ + + G+Y
Sbjct: 5152 VTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQY 5211
Query: 107 YCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSD-VRGNFYQEKTVFLRCTVNSNPPA 165
K EN G + + + P T T D V G+ ++ + C V+ + P
Sbjct: 5212 TFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGS-----SIHMECKVSGSLPI 5266
Query: 166 RFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIP 225
W + +S S + +E + L++ NL +D A+YTC+VS NV G
Sbjct: 5267 SAQWFKDGKEISTSAKYRLVCHE------RSVSLEVNNLELEDTANYTCKVS--NVAG-- 5316
Query: 226 DKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG 285
D A + LT PP+ + + P V + +L G P +++W L G
Sbjct: 5317 DDACSGILT-VKEPPSFLVKPGRQQAI-PDSTVEFKAILKGTPPF-KIKWFKDDVELVSG 5373
Query: 286 ALA----QGGT--LSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPD 339
+G T L++ SV A +G Y C TN+VG+ + T+ L+ K
Sbjct: 5374 PKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFV------K 5427
Query: 340 VIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSS 399
++ S+ ++ G +L C + P+ +V WF+N S + +T D +
Sbjct: 5428 KLEASKIVKAGDSSRLECKIAGSPEIRVV--WFRNEHELPASDKYRMTFIDS-----VAV 5480
Query: 400 LELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPA 459
+++ +L D G ++C A P S + + P S P +V + +
Sbjct: 5481 IQMNNLSTEDSGDFICEAQNPAG---STSCSTKVIVKEPPVFSSFP---PIVETLKNAEV 5534
Query: 460 ELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARY 519
L+CE+ G P V+W + ++ + + + V G Y C+
Sbjct: 5535 SLECELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNE 5594
Query: 520 NGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKG 579
G + + ++ PP + G P L+ S+ P + W +
Sbjct: 5595 VGSDT----CVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQ---WLKEK 5647
Query: 580 QLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVG 622
+ + + A L+ ++G Y C + ND G
Sbjct: 5648 EEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGG 5690
Score = 103 bits (256), Expect = 1e-21
Identities = 130/597 (21%), Positives = 231/597 (38%), Gaps = 67/597 (11%)
Query: 53 GDTLMLQCLVTGHPRPQVRW----TKTAGSASDKFQETSVFNETLRIERIARTQGGRYYC 108
G+ LQC V G P ++ W TK + + K Q + +L I ++ + G Y C
Sbjct: 7034 GEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNV-ASLVINKVDHSDVGEYSC 7092
Query: 109 KAENGVGVPAIKSIRVDVQ-----YLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNP 163
KA+N VG A ++ V + + VH+T+ V C +N +
Sbjct: 7093 KADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGF---------PVAFECRINGSE 7143
Query: 164 PARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCG 223
P + W + L + + T L++ Y C S N G
Sbjct: 7144 PLQVSWYKDGVLLKDDANLQTSFVHNVAT------LQILQTDQSHIGQYNCSAS--NPLG 7195
Query: 224 IPDKAITFRLTNTTAPPALKLS-VNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGP--- 279
+ L+ PP L V+ L + GE+ T +C +TG P+ ++ W+
Sbjct: 7196 TASSSAKLILSEHEVPPFFDLKPVSVDLAL--GESGTFKCHVTGTAPI-KITWAKDNREI 7252
Query: 280 ---GPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQI 336
G + + TL++ V D+G Y C A+N G + + L V+ ++
Sbjct: 7253 RPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDS-CSAQLGVQEPPRFIKKL 7311
Query: 337 TPD-VIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPA 395
P ++K+ E + C + P+ KV W+K+ + S + ++ D
Sbjct: 7312 EPSRIVKQDE------FTRYECKIGGSPEIKVL--WYKDETEIQESSKFRMSFVDS---- 7359
Query: 396 VTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVRE 455
+ LE+ +L D G Y C A S + S + P I K + T++
Sbjct: 7360 -VAVLEMHNLSVEDSGDYTCEAHNAAG-----SASSSTSLKVKEPPIFRKKPHPIETLK- 7412
Query: 456 GSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQ 515
G+ L+CE++G P V W + +E + E + + V G Y+C+
Sbjct: 7413 GADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCK 7472
Query: 516 TARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW 575
+V + ++ PP D+ +G+ V L+ ++ P S VW
Sbjct: 7473 ATN----DVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEP---ISVVW 7525
Query: 576 -RFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVS 631
+ KG+++ + + + + A L+ V ++G Y C + ND G C +S
Sbjct: 7526 FKDKGEIVRESDNI-WISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLS 7581
Score = 99.8 bits (247), Expect = 1e-20
Identities = 139/602 (23%), Positives = 228/602 (37%), Gaps = 69/602 (11%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTK--TAGSASDKFQETSVFN-ETLRIERIARTQGGRY 106
+++ + +C + G P +V W K T S KF+ + V + L + ++ G Y
Sbjct: 7317 VKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDY 7376
Query: 107 YCKAENGVGVPAIKSIRVDVQYLDEPMLTVH-QTVSDVRGNFYQEKTVFLRCTVNSNPPA 165
C+A N G S ++ + P+ + ++G V L C + PP
Sbjct: 7377 TCEAHNAAGSA---SSSTSLKVKEPPIFRKKPHPIETLKG-----ADVHLECELQGTPPF 7428
Query: 166 RFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIP 225
W + L + + ++ + + N+ D Y C+ + N G
Sbjct: 7429 HVSWYKDKRELRSGKKYKI------MSENFLTSIHILNVDAADIGEYQCKAT--NDVGSD 7480
Query: 226 DKAITFRLTNTTAPPAL--KLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP 283
+ L APP KLS T+V G+ V +Q + G +P+ + W G +
Sbjct: 7481 TCVGSIALK---APPRFVKKLSDISTVV---GKEVQLQTTIEGAEPI-SVVWFKDKGEIV 7533
Query: 284 -------LGALAQGGTLSIPSVQARDSGYYNCTATNNVG-NPAKKTVNLLVRSMKNATFQ 335
+ TL V+ ++G Y C N+ G T+++L + AT
Sbjct: 7534 RESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVL----EPATIV 7589
Query: 336 ITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPA 395
P+ IK + G L C V P+ ++ +WFK+GK + ++ +
Sbjct: 7590 EKPESIK----VTTGDTCTLECTVAGTPE--LSTKWFKDGKELTSDNKYKISFFNK---- 7639
Query: 396 VTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVRE 455
S L++I++ SD G Y P + + +S TVPP+ + +
Sbjct: 7640 -VSGLKIINVAPSDSGVYSFEVQNPVGK-DSCTASLQVSDRTVPPSFT--RKLKETNGLS 7695
Query: 456 GSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGK---LRLERVSRDMSGTY 512
GS ++C+V G P V W E + SG + T L + + SG Y
Sbjct: 7696 GSSVVMECKVYGSPPISVSWFHEGNE---ISSGRKYQTTLTDNTCALTVNMLEESDSGDY 7752
Query: 513 RCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIAS 572
C G + E L V+ PP + G V S+++G+P S
Sbjct: 7753 TCIATNMAGSD----ECSAPLTVREPPSFVQKPDPMDVLTGTNVTFT-SIVKGTPP--FS 7805
Query: 573 AVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSA 632
W FKG P + AEL L V SG Y C VSN+ G A+C +
Sbjct: 7806 VSW-FKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYI 7864
Query: 633 KA 634
KA
Sbjct: 7865 KA 7866
Score = 99.4 bits (246), Expect = 1e-20
Identities = 134/601 (22%), Positives = 218/601 (36%), Gaps = 60/601 (9%)
Query: 48 YTIREGDTLMLQCLVTGHPRPQVRWTKTAG--SASDKFQETSVFNET-LRIERIARTQGG 104
+++ G ++L+ TG P V W K S S++ T T L I
Sbjct: 6936 FSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYA 6995
Query: 105 RYYCKAENGVGVPAIKSI--RVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSN 162
+Y C EN G +++ ++ Y EP+ V + + L+C V+
Sbjct: 6996 QYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGE---------PATLQCKVDGT 7046
Query: 163 PPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVC 222
P R W + H++ Y+ + + L + + D Y+C+ N
Sbjct: 7047 PEIRISWYK-----EHTKLRSAPAYK-MQFKNNVASLVINKVDHSDVGEYSCKAD--NSV 7098
Query: 223 GIPDKAITFRLTNTTAPP--ALKL-SVNETLVVNPGENVTVQCLLTGGDPLPQLQW---- 275
G + + PP A KL V+ETL G V +C + G +PL Q+ W
Sbjct: 7099 GAVASSAVLVIKARKLPPFFARKLKDVHETL----GFPVAFECRINGSEPL-QVSWYKDG 7153
Query: 276 --SHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNAT 333
L + TL I G YNC+A+N +G + +L
Sbjct: 7154 VLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPF 7213
Query: 334 FQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPEL 393
F + P S ++ LG+ CHV K+T W K+ + R +T L
Sbjct: 7214 FDLKP----VSVDLALGESGTFKCHVTGTAPIKIT--WAKDNREIRPGGNYKMT-----L 7262
Query: 394 PAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTV 453
T++L ++ + D G Y C AS A S ++ + PP + K V
Sbjct: 7263 VENTATLTVLKVGKGDAGQYTCYAS-NIAGKDSCSAQLGVQE---PPRF-IKKLEPSRIV 7317
Query: 454 REGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYR 513
++ +C++ G P VLW + + E L + +S + SG Y
Sbjct: 7318 KQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYT 7377
Query: 514 CQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASA 573
C+ G + L V+ PP + G V L C L P ++
Sbjct: 7378 CEAHNAAG----SASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVS-- 7431
Query: 574 VWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
W + L +E + + V G Y+C +NDVGS C+ ++ K
Sbjct: 7432 -WYKDKRELRSGKKYKIMSE-NFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALK 7489
Query: 634 A 634
A
Sbjct: 7490 A 7490
Score = 98.2 bits (243), Expect = 3e-20
Identities = 115/471 (24%), Positives = 182/471 (38%), Gaps = 58/471 (12%)
Query: 194 GETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAP--------PALKLS 245
G+ L L P+D A YTC+ +++ + +P PA+
Sbjct: 3291 GQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITP 3350
Query: 246 VNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP------LGALAQGGTLSIPSVQ 299
+ +T V + G+ QC ++G D ++ W + + L I
Sbjct: 3351 LQDT-VTSEGQPARFQCRVSGTDL--KVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAY 3407
Query: 300 ARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIK-------------ESEN 346
D G Y A+N VG T NL + + ++ + I+ E
Sbjct: 3408 PEDEGTYTFVASNAVGQ-VSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLE 3466
Query: 347 IQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLH 406
+ LG K +C + + P V +QWFK G+ S + + + SSLE++
Sbjct: 3467 VALGHLAKFTCEIQSAPN--VRFQWFKAGREIYESDKCSIRSSK-----YISSLEILRTQ 3519
Query: 407 FSDYGTYLCMASFPGAPVPDLSVEVNIS-SETVPPT-ISVPKGRAVVTVREGSPAELQCE 464
D G Y C AS V S ++ +E PPT +S PK +T G A+ C
Sbjct: 3520 VVDCGEYTCKASNEYGSV---SCTATLTVTEAYPPTFLSRPKS---LTTFVGKAAKFICT 3573
Query: 465 VRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGK--LRLERVSRDMSGTYRCQTARYNGF 522
V G P +W + AAL PS + K L L ++ G Y C+ + G
Sbjct: 3574 VTGTPVIETIWQK--DGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGA 3631
Query: 523 NVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLL 582
++ E + F E+EP V+ A+ + V L C + R + W GQ L
Sbjct: 3632 DICQAELIIIDKPHFIKELEP----VQSAINKKVHLECQV---DEDRKVTVTWSKDGQKL 3684
Query: 583 PPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
PP E A L + SG+Y C+ SN+ GS++C V+ +
Sbjct: 3685 PPGKDYKICFE-DKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVR 3734
Score = 97.1 bits (240), Expect = 7e-20
Identities = 165/714 (23%), Positives = 262/714 (36%), Gaps = 86/714 (12%)
Query: 48 YTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF---NETLRIERIARTQGG 104
Y + G++ L C + G P QV W K S+ F L I + G
Sbjct: 3747 YLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSG 3806
Query: 105 RYYCKAENGVGVPAIKSIRVDVQYLDEP--MLTVHQTVSDVRGNFYQEKTVFLRCTVNSN 162
Y C+A N VG + + V + EP + + VRG L+C V+
Sbjct: 3807 SYSCEAVNDVGSDSCSTEIV----IKEPPSFIKTLEPADIVRGT-----NALLQCEVSGT 3857
Query: 163 PPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVC 222
P W + + S+ L++Q L++ + D Y C V+ N
Sbjct: 3858 GPFEISWFKDKKQIRSSKK------YRLFSQKSLVCLEIFSFNSADVGEYECVVA--NEV 3909
Query: 223 GIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHG---- 278
G T L PP V++ L+ G+ VT+Q + G +P+ + W G
Sbjct: 3910 GKCGCMATHLLKE---PPTFVKKVDD-LIALGGQTVTLQAAVRGSEPI-SVTWMKGQEVI 3964
Query: 279 --PGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQI 336
G + + L IP VQ G Y C A N G+ S+ +
Sbjct: 3965 REDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQT---------SVGELIVKE 4015
Query: 337 TPDVIKESENIQL--GQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVT-RNDPEL 393
+I+ +E IQ+ G L V P+ K +W+K+G+P SK+ ++ +N+
Sbjct: 4016 PAKIIERAELIQVTAGDPATLEYTVAGTPELKP--KWYKDGRPLVASKKYRISFKNN--- 4070
Query: 394 PAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEV--NISSETVPPTISVPKGRAVV 451
+ L+ D G Y S V S E + + P + P R V
Sbjct: 4071 ---VAQLKFYSAELHDSGQYTFEIS---NEVGSSSCETTFTVLDRDIAPFFTKPL-RNVD 4123
Query: 452 TVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGT 511
+V G+ L C++ G V W + KE A L + RV + +G
Sbjct: 4124 SVVNGT-CRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGN 4182
Query: 512 YRCQTARYNGFNVRPREAQVQLNVQFPPE--VEPSSQDVRQALGRPVLLRCSLLRGSPQR 569
+ C+ +V +++ L VQ PP +P S+DV G V L+ + +P
Sbjct: 4183 FTCRATN----SVGSKDSSGALIVQEPPSFVTKPGSKDVLP--GSAVCLKSTFQGSTPLT 4236
Query: 570 IASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQ 629
I W FKG + + L L V SG+Y C VSN G C
Sbjct: 4237 IR---W-FKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSAN 4292
Query: 630 VSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHN-A 688
+ K P + + P++ K + T P + N R I++ ++H +
Sbjct: 4293 LFVK--EPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDR-EIKESSKHRMS 4349
Query: 689 VVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEP 742
V++ V R LTD+ + S E G+ +S +I P
Sbjct: 4350 FVESTAVLR----------LTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESP 4393
Score = 95.5 bits (236), Expect = 2e-19
Identities = 161/715 (22%), Positives = 266/715 (37%), Gaps = 94/715 (13%)
Query: 60 CLVTGHPRPQVRWTK--TAGSASDKFQETSVFNE-TLRIERIARTQGGRYYCKAENGVGV 116
C VTG P + W K A S S ++ + N+ L + + G Y CKA N G
Sbjct: 3572 CTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGA 3631
Query: 117 PAIKS--IRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSD 174
++ I +D + + + V ++ K V L C V+ + W +
Sbjct: 3632 DICQAELIIIDKPHFIKELEPVQSAIN---------KKVHLECQVDEDRKVTVTWSKDGQ 3682
Query: 175 TLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLT 234
L +D + + + T E + KLK D +Y C S +T R
Sbjct: 3683 KLPPGKDYKICFEDKIATL-EIPLAKLK-----DSGTYVCTASNEAGSSSCSATVTVR-- 3734
Query: 235 NTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP------LGALA 288
PP+ V+ + ++ PGE+ + C L G P+ Q+ W L + +
Sbjct: 3735 ---EPPSFVKKVDPSYLMLPGESARLHCKLKGS-PVIQVTWFKNNKELSESNTVRMYFVN 3790
Query: 289 QGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIK--ESEN 346
L I V+ DSG Y+C A N+VG+ + T + P IK E +
Sbjct: 3791 SEAILDITDVKVEDSGSYSCEAVNDVGSDSCST---------EIVIKEPPSFIKTLEPAD 3841
Query: 347 IQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLH 406
I G + L C V +++ WFK+ K R SK+ + + LE+ +
Sbjct: 3842 IVRGTNALLQCEVSGTGPFEIS--WFKDKKQIRSSKKYRLFSQKSLV-----CLEIFSFN 3894
Query: 407 FSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVR 466
+D G Y C+ + ++ + PPT V K ++ + G LQ VR
Sbjct: 3895 SADVGEYECVVANEVGKCGCMATHLLKE----PPTF-VKKVDDLIALG-GQTVTLQAAVR 3948
Query: 467 GKPRPPVLWSRVD-------KEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARY 519
G V W + K +G+ + PD V G Y C
Sbjct: 3949 GSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPD-------VQISFGGKYTCLAENE 4001
Query: 520 NGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKG 579
G E L V+ P ++ ++ ++ G P L ++ G+P+ W G
Sbjct: 4002 AGSQTSVGE----LIVKEPAKIIERAELIQVTAGDPATLEYTVA-GTPE--LKPKWYKDG 4054
Query: 580 QLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAAC--LFQVSAKAYSP 637
+ L + + + A+L+ + SG Y +SN+VGS++C F V + +P
Sbjct: 4055 RPLVASKKYRISFKN-NVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAP 4113
Query: 638 EFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRR 697
F K +N V+ T R + L R+S + + A +
Sbjct: 4114 FF----------TKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAF 4163
Query: 698 VEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEP--INSPNLSD 750
VE LE I D+ ++ R T + G+ D + +I P + P D
Sbjct: 4164 VEGTASLEIIRVDMNDAGNFTCRAT--NSVGSKDSSGALIVQEPPSFVTKPGSKD 4216
Score = 95.1 bits (235), Expect = 3e-19
Identities = 133/598 (22%), Positives = 217/598 (36%), Gaps = 66/598 (11%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFN-------ETLRIERIARTQGGR 105
GD+ LQC + G P V W K K + T+ + TL ++ G
Sbjct: 7975 GDSASLQCQLAGTPEIGVSWYK----GDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGE 8030
Query: 106 YYCKAENGVG-VPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPP 164
Y CKAEN VG V A + V Q L + V + G V C ++ + P
Sbjct: 8031 YICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVG-----LPVVFDCAISGSEP 8085
Query: 165 ARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGI 224
W + L S + + T L + Y+C + N G
Sbjct: 8086 ISVSWYKDGKPLKDSPNVQTSFLD------NTATLNIFKTDRSLAGQYSCTAT--NPIGS 8137
Query: 225 PDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWS------HG 278
+ LT PP + + V GE+ +C +TG P+ ++ W+
Sbjct: 8138 ASSSARLILTEGKNPPFFDIRLAPVDAV-VGESADFECHVTGTQPI-KVSWAKDSREIRS 8195
Query: 279 PGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPA-KKTVNLLVRSMKNATFQIT 337
G + L L++ V DSG Y C A N VG + +N+ R + + +
Sbjct: 8196 GGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRL 8255
Query: 338 PDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVT 397
+ ++E+E G KL V + +T W+KN + + +T + L
Sbjct: 8256 SETVEETE----GNSFKLEGRVAG--SQPITVAWYKNNIEIQPTSNCEITFKNNTLV--- 8306
Query: 398 SSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGS 457
L++ +D G Y C S S + I PP + VTV EG
Sbjct: 8307 --LQVRKAGMNDAGLYTCKVSNDAGSALCTS-SIVIKEPKKPPVFD--QHLTPVTVSEGE 8361
Query: 458 PAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGK--LRLERVSRDMSGTYRCQ 515
+L C V+G + W + +E + PS G L L V++ SG Y C+
Sbjct: 8362 YVQLSCHVQGSEPIRIQWLKAGRE--IKPSDRCSFSFASGTAVLELRDVAKADSGDYVCK 8419
Query: 516 TARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVR----------QALGRPVLLRCSLLRG 565
+ G + + ++ P + ++ D R + + + + + G
Sbjct: 8420 ASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGG 8479
Query: 566 SPQRIASAVW-RFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVG 622
P I + W + K + L V + D A+L + T+ SG Y C N+ G
Sbjct: 8480 DP--IPNVKWTKGKWRQLNQGGRV-FIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHG 8534
Score = 94.4 bits (233), Expect = 5e-19
Identities = 119/532 (22%), Positives = 201/532 (37%), Gaps = 59/532 (11%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE---TLRIERIARTQGGRYYCK 109
G ++ C ++G V W K D + F + TL I + R+ G+Y C
Sbjct: 8071 GLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCT 8130
Query: 110 AENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIW 169
A N +G + + + + + P + D ++ C V P + W
Sbjct: 8131 ATNPIGSASSSARLILTEGKNPPFFDIRLAPVDA----VVGESADFECHVTGTQPIKVSW 8186
Query: 170 KRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAI 229
+ S + Y+ Y + + LK + D YTC N G
Sbjct: 8187 AKDSREIRSGGK-----YQISYLENSAHLTVLK-VDKGDSGQYTCYAV--NEVGKDSCTA 8238
Query: 230 TFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALA- 288
+ PP+ ++ET+ G + ++ + G P+ + + P
Sbjct: 8239 QLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEI 8298
Query: 289 --QGGTLSIPSVQA--RDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATF---QITPDVI 341
+ TL + +A D+G Y C +N+ G+ A T +++++ K +TP +
Sbjct: 8299 TFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGS-ALCTSSIVIKEPKKPPVFDQHLTPVTV 8357
Query: 342 KESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLE 401
E E +QL SCHV E + QW K G+ + S R + + T+ LE
Sbjct: 8358 SEGEYVQL------SCHVQG--SEPIRIQWLKAGREIKPSDRCSFS-----FASGTAVLE 8404
Query: 402 LIDLHFSDYGTYLCMAS-FPGAPVPDLSVEVNISSETVPPT-----------ISVPKGRA 449
L D+ +D G Y+C AS G+ V + P T +S P+
Sbjct: 8405 LRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIR 8464
Query: 450 VVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPL--EETPDGKLRLERVSRD 507
VV E + A +V G P P V W++ K L G ++ + KL + ++
Sbjct: 8465 VV---EKTTATFIAKVGGDPIPNVKWTK-GKWRQLNQGGRVFIHQKGDEAKLEIRDTTKT 8520
Query: 508 MSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLR 559
SG YRC +G E+ V L V + E D+R L + +L+
Sbjct: 8521 DSGLYRCVAFNEHG----EIESNVNLQVDERKKQEKIEGDLRAMLKKTPILK 8568
Score = 94.0 bits (232), Expect = 6e-19
Identities = 146/608 (24%), Positives = 223/608 (36%), Gaps = 87/608 (14%)
Query: 53 GDTLMLQCLVTGHPRPQVRW--TKTAGSASDKFQETSVFNE-TLRIERIARTQGGRYYCK 109
G + +L+C V G V W KT + K+Q T N TL++ + + G Y C
Sbjct: 5814 GASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCV 5873
Query: 110 AENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQE----KTVFLRCTVNSNPPA 165
A N G +++ LTV + S V+ E K V + PP
Sbjct: 5874 AANVAGSDECRAV-----------LTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPF 5922
Query: 166 RFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIP 225
+ W RG+ L + Y + L+L N+ YTC VS N G
Sbjct: 5923 KVNWFRGARELVKGDRCNI------YFEDTVAELELFNIDISQSGEYTCVVS--NNAG-- 5972
Query: 226 DKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG 285
+ T RL PA L V PG+++ ++ TG P+ + W +
Sbjct: 5973 QASCTTRLF--VKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPI-SVTWKKDGFNITTS 6029
Query: 286 ALAQGGT------LSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPD 339
T L I + RD+G Y+C N G + LV +++ P
Sbjct: 6030 EKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAG---RDVCGALVSTLE------PPY 6080
Query: 340 VIKESENIQ--LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSK--RLLVTRNDPELPA 395
+ E E ++ +G + L C V P+ +T W+K R + R T N
Sbjct: 6081 FVTELEPLEAAVGDSVSLQCQVAGTPE--ITVSWYKGDTKLRPTPEYRTYFTNN------ 6132
Query: 396 VTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVRE 455
++L ++ +D G Y C A +V I +PP+ + TV
Sbjct: 6133 -VATLVFNKVNINDSGEYTCKAENSIGTASSKTV-FRIQERQLPPSFARQLKDIEQTV-- 6188
Query: 456 GSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEET-PDGKLRLERVSRDMS--GTY 512
G P L C + G V W R + LL L+ + D L+ + D+S G Y
Sbjct: 6189 GLPVTLTCRLNGSAPIQVCWYR---DGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQY 6245
Query: 513 RCQTARYNGFNVRPREAQVQLNVQFPP-----EVEPSSQDVRQALGRPVLLRCSLLRGSP 567
C + G + +L + P +++P S DV G C + P
Sbjct: 6246 SCSASNPLG----TASSSARLTAREPKKSPFFDIKPVSIDV--IAGESADFECHVTGAQP 6299
Query: 568 QRIASAVWRFKGQLLPPPP--VVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAA 625
RI W + + P + P LR+ V + SG Y C +NDVG
Sbjct: 6300 MRIT---WSKDNKEIRPGGNYTITCVGNTP---HLRILKVGKGDSGQYTCQATNDVGKDM 6353
Query: 626 CLFQVSAK 633
C Q+S K
Sbjct: 6354 CSAQLSVK 6361
Score = 93.2 bits (230), Expect = 1e-18
Identities = 134/606 (22%), Positives = 227/606 (37%), Gaps = 61/606 (10%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTA-----GSASDKFQETSVFNETLRIERIARTQGGRYY 107
G + +V G P V W K + G + E SV L + + +Q G Y
Sbjct: 7789 GTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAE--LELFDVDTSQSGEYT 7846
Query: 108 CKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARF 167
C N G K+ Y+ P V + ++D + + K + L T PP
Sbjct: 7847 CIVSNEAG----KASCTTHLYIKAPAKFVKR-LNDY--SIEKGKPLILEGTFTGTPPISV 7899
Query: 168 IWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDK 227
WK+ ++ SQ + E ++ +L++ + +D Y C + N G
Sbjct: 7900 TWKKNGINVTPSQRCNITTTE------KSAILEIPSSTVEDAGQYNCYIE--NASGKDSC 7951
Query: 228 AITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPL----- 282
+ + P + E + V+ G++ ++QC L G P + W G L
Sbjct: 7952 SAQILILE----PPYFVKQLEPVKVSVGDSASLQCQLAG-TPEIGVSWYKGDTKLRPTTT 8006
Query: 283 -PLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVI 341
+ TL V DSG Y C A N+VG + T L V+ K + P
Sbjct: 8007 YKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTF-LTVQEQK-----LPPSFS 8060
Query: 342 KESENIQ--LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSS 399
++ ++Q +G + C + E ++ W+K+GKP + S + + D T++
Sbjct: 8061 RQLRDVQETVGLPVVFDCAISG--SEPISVSWYKDGKPLKDSPNVQTSFLDN-----TAT 8113
Query: 400 LELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPA 459
L + S G Y C A+ P S + ++ PP + A V G A
Sbjct: 8114 LNIFKTDRSLAGQYSCTATNPIGSASS-SARLILTEGKNPPFFDIRL--APVDAVVGESA 8170
Query: 460 ELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEET---PDGKLRLERVSRDMSGTYRCQT 516
+ +C V G V W++ +E + SG + + L + +V + SG Y C
Sbjct: 8171 DFECHVTGTQPIKVSWAKDSRE---IRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYA 8227
Query: 517 ARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWR 576
G + + ++ + P + S+ V + G L + P +A W
Sbjct: 8228 VNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVA---W- 8283
Query: 577 FKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYS 636
+K + P + L++ + +G Y C VSND GSA C + K
Sbjct: 8284 YKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPK 8343
Query: 637 PEFYFD 642
FD
Sbjct: 8344 KPPVFD 8349
Score = 92.4 bits (228), Expect = 2e-18
Identities = 125/597 (20%), Positives = 223/597 (37%), Gaps = 48/597 (8%)
Query: 48 YTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQ---ETSVFNETLRIERIARTQGG 104
Y+I +G L+L+ TG P V W K + + + T+ + L I G
Sbjct: 7877 YSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAG 7936
Query: 105 RYYCKAENGVGVPAIKS--IRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSN 162
+Y C EN G + + + ++ Y + + V +V D + L+C +
Sbjct: 7937 QYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGD---------SASLQCQLAGT 7987
Query: 163 PPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVC 222
P W +G L + ++ + L + D Y C+ N
Sbjct: 7988 PEIGVSWYKGDTKLRPTTT------YKMHFRNNVATLVFNQVDINDSGEYICK--AENSV 8039
Query: 223 GIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPL 282
G + + PP+ + + + G V C ++G +P+ + W PL
Sbjct: 8040 GEVSASTFLTVQEQKLPPSFSRQLRD-VQETVGLPVVFDCAISGSEPI-SVSWYKDGKPL 8097
Query: 283 ------PLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQI 336
L TL+I +G Y+CTATN +G+ A + L++ KN F
Sbjct: 8098 KDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGS-ASSSARLILTEGKNPPFF- 8155
Query: 337 TPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAV 396
D+ + +G+ CHV KV+ W K+ + R + ++ +
Sbjct: 8156 --DIRLAPVDAVVGESADFECHVTGTQPIKVS--WAKDSREIRSGGKYQISYLEN----- 8206
Query: 397 TSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREG 456
++ L ++ + D G Y C A + ++NI +PP+ + + V EG
Sbjct: 8207 SAHLTVLKVDKGDSGQYTCYA-VNEVGKDSCTAQLNIKERLIPPSFT-KRLSETVEETEG 8264
Query: 457 SPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQT 516
+ +L+ V G V W + + E + + L++ + + +G Y C+
Sbjct: 8265 NSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKV 8324
Query: 517 ARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWR 576
+ G + ++ + PP + V + G V L C + P RI W
Sbjct: 8325 SNDAGSALCTSSIVIK-EPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQ---WL 8380
Query: 577 FKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
G+ + P + + A A L L V + SG Y C SN GS +V+ K
Sbjct: 8381 KAGREIKPSDRC-SFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIK 8436
Score = 90.1 bits (222), Expect = 9e-18
Identities = 121/621 (19%), Positives = 223/621 (35%), Gaps = 70/621 (11%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE---TLRIERIARTQGGRYYCK 109
G T Q + G V W K + ++ F +L + I G+Y C+
Sbjct: 4500 GGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQ 4559
Query: 110 AENGVGVPAIKSIRVDVQYLDEPMLTVHQTVS-DVRGNFYQEKTVFLRCTVNSNPPARFI 168
A+N G+ ++ + EP + VS DV Q L+ +
Sbjct: 4560 AKNDAGIQRCSALLS----VKEPATITEEAVSIDVT----QGDPATLQVKFSGTKEITAK 4611
Query: 169 WKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKA 228
W + L+ + + + + +LK+ + +D YT +V +N G
Sbjct: 4612 WFKDGQELTLGSKYKISVTDTV------SILKIISTEKKDSGEYTFEV--QNDVGRSSCK 4663
Query: 229 ITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALA 288
+ + PP+ + + + G + ++C++ G P+ +QW +
Sbjct: 4664 ARINVLDLIIPPSFTKKLKKMDSIK-GSFIDLECIVAGSHPI-SIQWFKDDQEISASEKY 4721
Query: 289 Q------GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIK 342
+ L I ++ DSG Y C+ATN G+ + + T + P ++
Sbjct: 4722 KFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHN---------QCSGHLTVKEPPYFVE 4772
Query: 343 ESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLEL 402
+ ++ + + ++ +T +WFK+ K V ++D ++SLEL
Sbjct: 4773 KPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDD-----TSTSLEL 4827
Query: 403 IDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQ 462
+D GTY+C S V + + + + P I P V+ +R G +
Sbjct: 4828 FAAKATDSGTYICQLS---NDVGTATSKATLFVKEPPQFIKKPS--PVLVLRNGQSTTFE 4882
Query: 463 CEVRGKPRPPVLW-------SRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQ 515
C++ G P+ V W + + K GL + ++ + SGTY C+
Sbjct: 4883 CQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARV-------ENSGTYVCE 4935
Query: 516 TARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW 575
G ++L V+ PP + V V L C + P + W
Sbjct: 4936 ARNDAG----TASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVT---W 4988
Query: 576 RFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAY 635
+ + + L + +G Y+C VSN+ GS +C +V+ K
Sbjct: 4989 LKNNREIRSSKKY-TLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKE- 5046
Query: 636 SPEFYFDTPNPTRSHKLSKNY 656
P F N T K S +
Sbjct: 5047 PPSFIKKIENTTTVLKSSATF 5067
Score = 84.0 bits (206), Expect = 6e-16
Identities = 140/653 (21%), Positives = 255/653 (39%), Gaps = 71/653 (10%)
Query: 1 MEVTCLLLLALIPFHCRGQGVY-APAQAQIVHAGQACVVKEDNISERVY----TIREGDT 55
+E T +L L + G+ + A +A H +VKE + + ++E D
Sbjct: 4351 VESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDV 4410
Query: 56 LMLQCLVTGHPRPQVRWTKT-----AGSASDKFQETSVFNETLRIERIARTQGGRYYCKA 110
++L V G P ++ W K +G F + + + L+I + G Y C+
Sbjct: 4411 MLL-AEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVS--LQILKFVAADAGEYQCRV 4467
Query: 111 ENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWK 170
N VG +I S RV ++ + + T S +RG T + T+ + P W
Sbjct: 4468 TNEVG-SSICSARVTLREPPSFIKKIEST-SSLRGG-----TAAFQATLKGSLPITVTWL 4520
Query: 171 RGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAIT 230
+ SD ++ +D+ + + + L L + + Y CQ +N GI +
Sbjct: 4521 KDSDEIT--EDDNIR----MTFENNVASLYLSGIEVKHDGKYVCQA--KNDAGIQRCSAL 4572
Query: 231 FRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQG 290
+ PA ++ V G+ T+Q +G + +W L LG+ +
Sbjct: 4573 LSVKE----PATITEEAVSIDVTQGDPATLQVKFSGTKEITA-KWFKDGQELTLGSKYKI 4627
Query: 291 GT------LSIPSVQARDSGYYNCTATNNVGNPA-KKTVNLLVRSMKNATFQITPDVIKE 343
L I S + +DSG Y N+VG + K +N+L I P K+
Sbjct: 4628 SVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVL-------DLIIPPSFTKK 4680
Query: 344 SENIQL--GQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLE 401
+ + G + L C V ++ QWFK+ + S++ + +D T+ LE
Sbjct: 4681 LKKMDSIKGSFIDLECIVAG--SHPISIQWFKDDQEISASEKYKFSFHDN-----TAFLE 4733
Query: 402 LIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAEL 461
+ L +D GTY C A+ +++ + P + P+ + V + +L
Sbjct: 4734 ISQLEGTDSGTYTCSATNKAG---HNQCSGHLTVKEPPYFVEKPQSQ---DVNPNTRVQL 4787
Query: 462 QCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNG 521
+ V G + W + +KE + ++ L L SGTY CQ +
Sbjct: 4788 KALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSN--- 4844
Query: 522 FNVRPREAQVQLNVQFPPE-VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQ 580
+V ++ L V+ PP+ ++ S + G+ C + G+P+ S W G
Sbjct: 4845 -DVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQIT-GTPKIRVS--WYLDGN 4900
Query: 581 LLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
+ + A ++ ++SG+Y C ND G+A+C ++ K
Sbjct: 4901 EITAIQK-HGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVK 4952
Score = 82.8 bits (203), Expect = 1e-15
Identities = 132/590 (22%), Positives = 214/590 (36%), Gaps = 54/590 (9%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTAGSA--SDKFQ-ETSVFNETLRIERIARTQGGRYYCK 109
G C + P + +W K SDK +S + +L I R G Y CK
Sbjct: 3470 GHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCK 3529
Query: 110 AENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIW 169
A N G + + + L+ ++++ G K CTV P IW
Sbjct: 3530 ASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVG-----KAAKFICTVTGTPVIETIW 3584
Query: 170 KRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAI 229
++ LS S + + E +L+L NL QD Y+C+ S + I
Sbjct: 3585 QKDGAALSPSPNWRISDAE------NKHILELSNLTIQDRGVYSCKASNKFGADI----C 3634
Query: 230 TFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGA--- 286
L P +K +N + V ++C + D + WS LP G
Sbjct: 3635 QAELIIIDKPHFIKELEPVQSAIN--KKVHLECQV-DEDRKVTVTWSKDGQKLPPGKDYK 3691
Query: 287 ---LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKE 343
+ TL IP + +DSG Y CTA+N G+ + + + VR + ++ P +
Sbjct: 3692 ICFEDKIATLEIPLAKLKDSGTYVCTASNEAGS-SSCSATVTVREPPSFVKKVDPSYL-- 3748
Query: 344 SENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELI 403
+ G+ +L C + P +VT WFKN K S + + + E + L++
Sbjct: 3749 ---MLPGESARLHCKLKGSPVIQVT--WFKNNKELSESNTVRMYFVNSE-----AILDIT 3798
Query: 404 DLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQC 463
D+ D G+Y C A V D+ + + + S K + G+ A LQC
Sbjct: 3799 DVKVEDSGSYSCEA------VNDVGSDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQC 3852
Query: 464 EVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFN 523
EV G + W + K+ + L + + G Y C A
Sbjct: 3853 EVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVAN----E 3908
Query: 524 VRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLP 583
V ++ PP D+ G+ V L+ ++ P S W KGQ +
Sbjct: 3909 VGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEP---ISVTW-MKGQEVI 3964
Query: 584 PPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
+ + A L + V G Y C N+ GS + ++ K
Sbjct: 3965 REDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVK 4014
Score = 82.8 bits (203), Expect = 1e-15
Identities = 132/600 (22%), Positives = 222/600 (37%), Gaps = 85/600 (14%)
Query: 59 QCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE---TLRIERIARTQGGRYYCKAENGVG 115
Q V G P + W K + F + TL+I + GRY C+A+N G
Sbjct: 5068 QSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESG 5127
Query: 116 VPAIKSIRVDVQYLDEPMLTVHQTVS-DVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSD 174
V + + + EP V + S DV ++ + L C V P + W +
Sbjct: 5128 VERCYAFLL----VQEPAQIVEKAKSVDVT----EKDPMTLECVVAGTPELKVKWLKDGK 5179
Query: 175 TLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLT 234
+ S+ Y + + +++++ QD YT +V N G R+
Sbjct: 5180 QIVPSR------YFSMSFENNVASFRIQSVMKQDSGQYTFKVE--NDFGSSSCDAYLRVL 5231
Query: 235 NTTAPPAL--KLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGAL----- 287
+ PP+ KL+ + ++ G ++ ++C ++G P+ QW + A
Sbjct: 5232 DQNIPPSFTKKLTKMDKVL---GSSIHMECKVSGSLPI-SAQWFKDGKEISTSAKYRLVC 5287
Query: 288 -AQGGTLSIPSVQARDSGYYNCTATNNVGNPA-------KKTVNLLVRSMKNATFQITPD 339
+ +L + +++ D+ Y C +N G+ A K+ + LV+ + Q PD
Sbjct: 5288 HERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQ---QAIPD 5344
Query: 340 VIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSS 399
E + I G P K+ +WFK+ + + L TS
Sbjct: 5345 STVEFKAILKG-----------TPPFKI--KWFKDDVELVSGPKCFIG-----LEGSTSF 5386
Query: 400 LELIDLHFSDYGTYLCMASFPGAPVPDLSVE--VNISSETVPPTISVPKGRAVVTVREGS 457
L L + S G Y C + D+ + + T PP V K A V+ G
Sbjct: 5387 LNLYSVDASKTGQYTCHVT------NDVGSDSCTTMLLVTEPPKF-VKKLEASKIVKAGD 5439
Query: 458 PAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEET---PDGKLRLERVSRDMSGTYRC 514
+ L+C++ G P V+W R + E LP+ T +++ +S + SG + C
Sbjct: 5440 SSRLECKIAGSPEIRVVWFRNEHE---LPASDKYRMTFIDSVAVIQMNNLSTEDSGDFIC 5496
Query: 515 QTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAV 574
+ G ++ V+ PP V V L C L P + V
Sbjct: 5497 EAQNPAGST----SCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEV---V 5549
Query: 575 W-RFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
W + K QL A+ H + + V G Y C N+VGS C+ V K
Sbjct: 5550 WYKDKRQLRSSKKYKIASKNF--HTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLK 5607
Score = 76.6 bits (187), Expect = 1e-13
Identities = 125/593 (21%), Positives = 220/593 (37%), Gaps = 62/593 (10%)
Query: 47 VYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQ---G 103
V +R G + +C +TG P+ +V W + + F + L +I+ +
Sbjct: 4870 VLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENS 4929
Query: 104 GRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNP 163
G Y C+A N G S ++++ + P T + + V Y + V L C V P
Sbjct: 4930 GTYVCEARNDAGTA---SCSIELKVKEPP--TFIRELKPVEVVKYSD--VELECEVTGTP 4982
Query: 164 PARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCG 223
P W + + + S+ + ++ L + P D Y C VS N G
Sbjct: 4983 PFEVTWLKNNREIRSSKKYTLTDRVSVFN------LHITKCDPSDTGEYQCIVS--NEGG 5034
Query: 224 IPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP 283
+ + R+ P +K N T V+ + T Q + G P+ + W L
Sbjct: 5035 --SCSCSTRVALKEPPSFIKKIENTTTVLK--SSATFQSTVAGSPPI-SITWLKDDQILD 5089
Query: 284 ------LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQIT 337
+ + TL I SV SG Y C A N G + R Q
Sbjct: 5090 EDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESG---------VERCYAFLLVQEP 5140
Query: 338 PDVIKESENIQLGQD--LKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPA 395
++++++++ + + + L C V P+ KV +W K+GK S+ ++ +
Sbjct: 5141 AQIVEKAKSVDVTEKDPMTLECVVAGTPELKV--KWLKDGKQIVPSRYFSMSFENN---- 5194
Query: 396 VTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVRE 455
+S + + D G Y + + + +PP+ + K +
Sbjct: 5195 -VASFRIQSVMKQDSGQYTFKVENDFGS-SSCDAYLRVLDQNIPPSFT--KKLTKMDKVL 5250
Query: 456 GSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQ 515
GS ++C+V G W + KE + + L + + + + Y C+
Sbjct: 5251 GSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCK 5310
Query: 516 TARYNGFNVRPREAQVQLNVQFPPE--VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASA 573
+ G + L V+ PP V+P Q QA+ + ++L+G+P
Sbjct: 5311 VSNVAGDDA----CSGILTVKEPPSFLVKPGRQ---QAIPDSTVEFKAILKGTPP--FKI 5361
Query: 574 VWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAAC 626
W L P E + L L +V +G Y C V+NDVGS +C
Sbjct: 5362 KWFKDDVELVSGPKCFIGLEGST-SFLNLYSVDASKTGQYTCHVTNDVGSDSC 5413
Score = 73.2 bits (178), Expect = 1e-12
Identities = 140/601 (23%), Positives = 220/601 (36%), Gaps = 58/601 (9%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGS--ASDKFQETSVFNET-LRIERIARTQGGRY 106
I G +LQC V+G ++ W K +S K++ S + L I G Y
Sbjct: 3842 IVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEY 3901
Query: 107 YCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPAR 166
C N VG K + L EP V + V D+ Q TV L+ V + P
Sbjct: 3902 ECVVANEVG----KCGCMATHLLKEPPTFVKK-VDDLIALGGQ--TVTLQAAVRGSEPIS 3954
Query: 167 FIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPD 226
W +G + + +D + + ++ G VL + +++ YTC N G
Sbjct: 3955 VTWMKGQEVIR--EDGKIKMS---FSNG-VAVLIIPDVQISFGGKYTCLAE--NEAGSQT 4006
Query: 227 KAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP--- 283
+ PA + E + V G+ T++ + G L +W PL
Sbjct: 4007 SVGELIVKE----PAKIIERAELIQVTAGDPATLEYTVAGTPELKP-KWYKDGRPLVASK 4061
Query: 284 ---LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDV 340
+ L S + DSG Y +N VG+ + +T ++ I P
Sbjct: 4062 KYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDR------DIAPFF 4115
Query: 341 IKESENIQ--LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTS 398
K N+ + +L C + +V+ WFK+GK S R + + T+
Sbjct: 4116 TKPLRNVDSVVNGTCRLDCKIAGSLPMRVS--WFKDGKEIAASDRYRIAFVEG-----TA 4168
Query: 399 SLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSP 458
SLE+I + +D G + C A+ V + + P ++ P + V+ GS
Sbjct: 4169 SLEIIRVDMNDAGNFTCRAT---NSVGSKDSSGALIVQEPPSFVTKPGSKDVLP---GSA 4222
Query: 459 AELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTAR 518
L+ +G + W + +KE S +E + L L V SGTY C+ +
Sbjct: 4223 VCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSN 4282
Query: 519 YNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFK 578
G V+ F ++EPS + G L C + P +I W F
Sbjct: 4283 VAGGVECSANLFVKEPATFVEKLEPSQLLKK---GDATQLACKVTGTPPIKI---TW-FA 4335
Query: 579 GQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPE 638
+ A LRL V + SG Y C N+ GS C V K SP
Sbjct: 4336 NDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKE-SPY 4394
Query: 639 F 639
F
Sbjct: 4395 F 4395
Score = 66.6 bits (161), Expect = 1e-10
Identities = 91/347 (26%), Positives = 124/347 (35%), Gaps = 48/347 (13%)
Query: 52 EGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQ-ETSVFNETL--RIERIARTQGGRYYC 108
EG++ L+ V G V W K E + N TL ++ + G Y C
Sbjct: 8263 EGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTC 8322
Query: 109 KAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFI 168
K N G S V + P+ H T V Y V L C V + P R
Sbjct: 8323 KVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEY----VQLSCHVQGSEPIRIQ 8378
Query: 169 WKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCG----- 223
W + + S D + G T VL+L+++ D Y C+ S NV G
Sbjct: 8379 WLKAGREIKPS-----DRCSFSFASG-TAVLELRDVAKADSGDYVCKAS--NVAGSDTTK 8430
Query: 224 ----IPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLL-TGGDPLPQLQWSHG 278
I DK T A V+E + E T + GGDP+P ++W+ G
Sbjct: 8431 SKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKG 8490
Query: 279 P-------GPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMK- 330
G + + L I DSG Y C A N G + VNL V K
Sbjct: 8491 KWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGE-IESNVNLQVDERKK 8549
Query: 331 --------NATFQITPDVIK---ESENIQLGQDLKLSCHVDAVPQEK 366
A + TP + K E E I + + LK +VD EK
Sbjct: 8550 QEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLK---NVDPKEYEK 8593
Score = 66.2 bits (160), Expect = 1e-10
Identities = 100/430 (23%), Positives = 168/430 (39%), Gaps = 58/430 (13%)
Query: 46 RVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQ-ETSVFNETLRIERIARTQGG 104
+V +R TL L + G P P+V+W K G +D+ Q E + L I+ + R G
Sbjct: 25115 KVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSG 25174
Query: 105 RYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPP 164
RY EN G K+ V+V+ LD P V+ T+ +V+ + T++ PP
Sbjct: 25175 RYNLTLENNSG---SKTAFVNVRVLDSPSAPVNLTIREVKKD---------SVTLSWEPP 25222
Query: 165 ARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGI 224
+ ++ + ++ Y + +++NL Q+ SY +V N GI
Sbjct: 25223 LIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENL--QEGCSYYFRVLASNEYGI 25280
Query: 225 PDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQW----SHGPG 280
A T + PP V TLV T++ D ++ G
Sbjct: 25281 GLPAETTEPVKVSEPPLPPGRV--TLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKG 25338
Query: 281 PLPLGALAQGGTL--SIPSVQARDSGYYNCTATNNVG--NPAKKTVNLLVRSMKNATFQI 336
Q TL +I + A + + A N G +P + V ++ R + +I
Sbjct: 25339 SEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDI-----EI 25393
Query: 337 TPDVIK--ESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELP 394
P V + N++ + LK+ PQ T W K+G+ + + R+ V+ +
Sbjct: 25394 KPSVELPFHTFNVKAREQLKIDVPFKGRPQ--ATVNWRKDGQTLKETTRVNVSSS----- 25446
Query: 395 AVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVR 454
+SL + + D GTY +L V + S TVP TI +V R
Sbjct: 25447 KTVTSLSIKEASKEDVGTY------------ELCVSNSAGSITVPITI-------IVLDR 25487
Query: 455 EGSPAELQCE 464
G P ++ +
Sbjct: 25488 PGPPGPIRID 25497
Score = 64.7 bits (156), Expect = 4e-10
Identities = 96/414 (23%), Positives = 167/414 (40%), Gaps = 56/414 (13%)
Query: 46 RVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDK--FQETSVFNETLRIERIARTQG 103
++ IR G +L L + G P P+V+W K G D TS F +L ++ + R
Sbjct: 22950 KIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFT-SLVLDNVNRYDS 23008
Query: 104 GRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNP 163
G+Y EN G KS V V+ LD P V+ V+++ + ++ P
Sbjct: 23009 GKYTLTLENSSGT---KSAFVTVRVLDTPSPPVNLKVTEITKD---------SVSITWEP 23056
Query: 164 PARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCG 223
P + + + ++ Y + T K+ L Q+ SY +V+ N G
Sbjct: 23057 PLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQL--QEGCSYYFRVTAENEYG 23114
Query: 224 IPDKAIT---FRLTNTTAPPAL---------KLSVNETLVVNPGENVTVQCLLTGGDPLP 271
I A T ++ PP +S++ T + G + +Q ++
Sbjct: 23115 IGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHS 23174
Query: 272 QLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVG--NPAKKTVNLLVRSM 329
+ +WS L A+ I ++ + + A N G +P V ++ + +
Sbjct: 23175 E-KWSECARVKSLQAV-------ITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDL 23226
Query: 330 KNATFQITPDV--IKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVT 387
I PDV S ++Q+GQDLK+ + P+ +T W K+G P + + R+ VT
Sbjct: 23227 -----VIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTIT--WTKDGLPLKQTTRINVT 23279
Query: 388 RNDPELPAVTSSLELIDLHFSDYGTY-LCMASFPGAPVPDLSVEVNISSETVPP 440
L T S++ + H D G Y + +A+ G S+E+ + PP
Sbjct: 23280 ---DSLDLTTLSIK--ETHKDDGGQYGITVANVVGQKT--ASIEIVTLDKPDPP 23326
Score = 59.7 bits (143), Expect = 1e-08
Identities = 90/400 (22%), Positives = 156/400 (39%), Gaps = 52/400 (13%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQ-ETSVFNETLRIERIARTQGGRYYC 108
+R G + + G P P++ W++ G +DK Q E V L I+ R G+Y
Sbjct: 24036 VRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYIL 24095
Query: 109 KAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFI 168
K EN G KS V V+ LD P + V +VR + + FL PP
Sbjct: 24096 KLENSSG---SKSAFVTVKVLDTPGPPQNLAVKEVR-----KDSAFLVW----EPPIIDG 24143
Query: 169 WKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKA 228
+ + + +++ Y + ++ K++NL + A Y +V N G+
Sbjct: 24144 GAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENL--TEGAIYYFRVMAENEFGVGVPV 24201
Query: 229 ITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALA 288
T PP +P VT+ + L + H G LG +
Sbjct: 24202 ETVDAVKAAEPP------------SPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVV 24249
Query: 289 Q---GGT-------------LSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNA 332
+ GT + + + + A N G + + + V + K+
Sbjct: 24250 EMQPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIA-KDL 24308
Query: 333 TFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPE 392
T Q + + + +IQ G+DLK+ V P+ ++ W K+G+P + + TR + E
Sbjct: 24309 TIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNIS--WVKDGEPLKQT-----TRVNVE 24361
Query: 393 LPAVTSSLELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEV 431
A ++ L + + + D+G Y A + G +LSV V
Sbjct: 24362 ETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIV 24401
Score = 54.7 bits (130), Expect = 4e-07
Identities = 119/518 (22%), Positives = 179/518 (34%), Gaps = 118/518 (22%)
Query: 52 EGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE----TLRIERIARTQGGRYY 107
EG T V G P P+ W + + V E +L I + G +
Sbjct: 1470 EGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWT 1529
Query: 108 CKAENGVGVPAIKSIRV--DVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPA 165
A+N G +I I V++ +PM +++ E V R T N NP
Sbjct: 1530 VVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKV--RATGNPNPD- 1586
Query: 166 RFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYT------------ 213
+W + SD + + + I T+GE LK+ + QD A YT
Sbjct: 1587 -IVWLKNSDIIVPHKYPKIRIEG---TKGEA-ALKIDSTVSQDSAWYTATAINKAGRDTT 1641
Query: 214 -CQVSVRNVCGIPD---KAI----TFRLTNTTAP-------------------------- 239
C+V+V P+ K I T+R AP
Sbjct: 1642 RCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQ 1701
Query: 240 -PALKLSVNETLVVNPGENVTVQCLLTG-GDPLPQLQWSHGPGPLP----LGALAQGGTL 293
P K + + G +C LT GDP ++W H PL L + + G
Sbjct: 1702 KPFFKKKLTSLRLKRFGP-AHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFGYC 1760
Query: 294 SIPS--VQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKN-------------------- 331
S+ +RDSG C ATN G + L+V+ K+
Sbjct: 1761 SLDYGVAYSRDSGIITCRATNKYGTD-HTSATLIVKDEKSLVEESQLPEGRKGLQRIEEL 1819
Query: 332 -------ATFQIT--------PDVIKESENIQL--GQDLKLSCHVDAVPQEKVTYQWFKN 374
A +T PD++ E +++ G+ + C V PQ KV W+ N
Sbjct: 1820 ERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVN--WYLN 1877
Query: 375 GKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP-GAPVPDLSVEVNI 433
G+ R SKR V + L+++D D G A P G + +E+
Sbjct: 1878 GQLIRKSKRFRVRYDG------IHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQ 1931
Query: 434 SSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRP 471
+ P+ R V E P +LQ EV+ RP
Sbjct: 1932 REDFRSVLRRAPEPRPEFHVHE--PGKLQFEVQKVDRP 1967
Score = 54.7 bits (130), Expect = 4e-07
Identities = 81/360 (22%), Positives = 140/360 (38%), Gaps = 56/360 (15%)
Query: 293 LSIPSVQARDSGYYNCTATNNVGNPAKKTV---NLLVRSMKNATFQITPDVIKESENIQL 349
L IPS + D+G Y A NV AK V ++ +RS+K VI++ +
Sbjct: 3114 LLIPSTRMSDAGKYTVVAGGNVST-AKLFVEGRDVRIRSIKKEV-----QVIEKQRAVVE 3167
Query: 350 GQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSD 409
+ V ++ V W+K+G + R+ + + + + SD
Sbjct: 3168 FE----------VNEDDVDAHWYKDGIEINFQVQ---ERHKYVVERRIHRMFISETRQSD 3214
Query: 410 YGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKP 469
G Y +A G +++ VN P V + VTV+ G PA + G+P
Sbjct: 3215 AGEYTFVA---GRNRSSVTLYVN-----APEPPQVLQELQPVTVQSGKPARFCAVISGRP 3266
Query: 470 RPPVLWSRVDKEAALLPSGLPLEETPDGK----LRLERVSRDMSGTYRCQTARYNGFNVR 525
+P + W KE LL +G + DG+ L +E D + Y C+ N + V
Sbjct: 3267 QPKISWY---KEEQLLSTGFKCKFLHDGQEYTLLLIEAFPED-AAVYTCEAK--NDYGVA 3320
Query: 526 PREAQVQLNVQ-----------FPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAV 574
A + + V +PP + QD + G+P +C + G+ +++
Sbjct: 3321 TTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCR-VSGTDLKVS--- 3376
Query: 575 WRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKA 634
W K + + P + D +L + + G+Y SN VG + +S +A
Sbjct: 3377 WYSKDKKIKPSRFF-RMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEA 3435
Score = 53.9 bits (128), Expect = 7e-07
Identities = 69/310 (22%), Positives = 128/310 (41%), Gaps = 53/310 (17%)
Query: 46 RVYTIREGDTLMLQCLVTGHPRPQVRWTKT---AGSASDKFQETSVFNETLRIERIARTQ 102
R I EG ++ C ++G P P++ W K +S+ S +L I + +
Sbjct: 33141 RSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSD 33200
Query: 103 GGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVS---DVRGNFYQEK-------- 151
G+Y KA+N G + + + + ++EP V S ++G+F +
Sbjct: 33201 SGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQ 33260
Query: 152 ----TVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQ 207
+ F + +S +F + ++S Q++ V++ + G + + +L+
Sbjct: 33261 EASFSSFSSSSASSMTEMKFA-SMSAQSMSSMQESFVEMSSSSF-MGISNMTQLE----- 33313
Query: 208 DYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGG 267
S T ++ + GIP K AL ++ ++ G+ +TV C T G
Sbjct: 33314 ---SSTSKMLKAGIRGIPPKI-----------EALPSDIS----IDEGKVLTVACAFT-G 33354
Query: 268 DPLPQLQWSHG--------PGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAK 319
+P P++ WS G G + TL I VQ +D G Y + N G+ +
Sbjct: 33355 EPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDS- 33413
Query: 320 KTVNLLVRSM 329
TVN+ +RS+
Sbjct: 33414 ATVNIHIRSI 33423
Score = 49.7 bits (117), Expect = 1e-05
Identities = 75/330 (22%), Positives = 122/330 (36%), Gaps = 35/330 (10%)
Query: 427 LSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLP 486
+S++ ++S P + K VT + G A+L C++ G+P P + W R KE L
Sbjct: 30521 MSIKTKLTSGEAP---GIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKE---LI 30574
Query: 487 SGLPLEETPDGK---LRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEP 543
+ + DG+ L + ++ G Y C G + +Q QF P P
Sbjct: 30575 QSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGY-P 30633
Query: 544 SSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLD 603
+ A+G + L + G P + + W F GQ L + L +
Sbjct: 30634 LKEKYYGAVGSTLRLHVMYI-GRP--VPAMTW-FHGQKLLQNSENITIENTEHYTHLVMK 30689
Query: 604 AVTRDS-SGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTP-NPTRSHKLSKNYSYVLQ 661
V R + +G Y+ +SN G+ + V + D P P L KN S V+
Sbjct: 30690 NVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKP-----DKPTGPIVIEALLKN-SAVIS 30743
Query: 662 WTQREPDAVDPVLNY---RLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYE 718
W D + NY + ++ + V AI V + +L Y
Sbjct: 30744 WKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCR--------IVNLTENAGYY 30795
Query: 719 VRLTPYTTFGAGD--MASRIIHYTEPINSP 746
R++ TFG D S ++ P P
Sbjct: 30796 FRVSAQNTFGISDPLEVSSVVIIKSPFEKP 30825
Score = 48.9 bits (115), Expect = 2e-05
Identities = 96/419 (22%), Positives = 156/419 (37%), Gaps = 64/419 (15%)
Query: 46 RVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRI-ERIARTQGG 104
+V TIR TL L + G P P+V+W + G + DK S + TL I + R G
Sbjct: 21868 KVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSG 21927
Query: 105 RYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPP 164
+Y EN G KS V+V+ LD P V +V KT T+ +PP
Sbjct: 21928 KYILTVENSSG---SKSAFVNVRVLDTPGPPQDLKVKEV------TKT---SVTLTWDPP 21975
Query: 165 ARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGI 224
+ + + +++ Y + T K+ L Q+ SY +V N GI
Sbjct: 21976 LLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQL--QEGCSYYFRVLAENEYGI 22033
Query: 225 PDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPL 284
A T + P P +T+ + L + H G L
Sbjct: 22034 GLPAETAESVKASERPL------------PPGKITLMDVTRNSVSLSWEKPEHDGGSRIL 22081
Query: 285 GALAQGGT---------LSIPSVQARDSGY-------YNCTATNNVG--NPAKKTVNLLV 326
G + + T ++ +A +G + +A N G +P + +V ++
Sbjct: 22082 GYIVEMQTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIA 22141
Query: 327 RSMKNATFQITPDVIK---ESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKR 383
+ + + P K + + G+DLK+ P VT W K+ P + +
Sbjct: 22142 KDL------VIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVT--WHKDNVPLKQT-- 22191
Query: 384 LLVTRNDPELPAVTSSLELIDLHFSDYGTYLC-MASFPGAPVPDLSVEVNISSETVPPT 441
TR + E S L + D D G Y+ + + G + L+V V + PPT
Sbjct: 22192 ---TRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIV--LDKPGPPT 22245
Score = 47.8 bits (112), Expect = 5e-05
Identities = 114/540 (21%), Positives = 194/540 (35%), Gaps = 105/540 (19%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFN-------ETLRIERIARTQ 102
+ E DT+ L C V+ P +V W K ++ ET + L I+
Sbjct: 12474 VSETDTIKLVCEVS-KPGAEVIWYK----GDEEIIETGRYEILTEGRKRILVIQNAHLED 12528
Query: 103 GGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSN 162
G Y C+ + +K + +++ +P Q + + G EK F+ +
Sbjct: 12529 AGNYNCRLPSSRTDGKVKVHELAAEFISKP-----QNLEILEG----EKAEFVCSISKES 12579
Query: 163 PPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVS----- 217
P + WKR TL D Y+ + G+ +VL +K+ QD +Y V
Sbjct: 12580 FPVQ--WKRDDKTLESG-----DKYDVI-ADGKKRVLVVKDATLQDMGTYVVMVGAARAA 12631
Query: 218 --------VRNVCGIPD------KAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCL 263
+R V + D + + F T K NE + + + + +Q
Sbjct: 12632 AHLTVIEKLRIVVPLKDTRVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKD 12691
Query: 264 LTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVN 323
L TL I D YN + TN+ G K N
Sbjct: 12692 LVY-------------------------TLRIRDAHLDDQANYNVSLTNHRGENVKSAAN 12726
Query: 324 LLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKR 383
L+V + +I + +K+ E ++ + + C V+ + VT +W KNG+ R
Sbjct: 12727 LIV---EEEDLRIV-EPLKDIETME-KKSVTFWCKVNRL---NVTLKWTKNGEEVPFDNR 12778
Query: 384 LLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTIS 443
+ + L + D F D G Y+ A + L +E PT
Sbjct: 12779 V-----SYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEA--------PTEF 12825
Query: 444 VPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLER 503
V + TV E A C++ + + V W R +E + G + DG +
Sbjct: 12826 V-EHLEDQTVTEFDDAVFSCQL-SREKANVKWYRNGRE---IKEGKKYKFEKDGSIH-RL 12879
Query: 504 VSRDMSGTYRCQTARYNGFNVRPREAQVQLNV-QFPPEVEPSSQDVRQALGRPVLLRCSL 562
+ +D C+ A V R+++ +L V + P E+ QD+ +A G V+ L
Sbjct: 12880 IIKDCRLDDECEYA----CGVEDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFLAEL 12935
Score = 47.0 bits (110), Expect = 9e-05
Identities = 39/134 (29%), Positives = 56/134 (41%), Gaps = 13/134 (9%)
Query: 21 VYAPAQAQIVHAGQACVVKE---------DNISERVYTIREGDTLMLQCLVTGHPRPQVR 71
V A ++ H + +VK+ D R I+ GDTL L ++ G P P+V
Sbjct: 17192 VNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVT 17251
Query: 72 WTKTAGSASDKFQ-ETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLD 130
W K A K + + + L I A GG Y EN G K++ V V LD
Sbjct: 17252 WKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAG---SKTVSVKVLVLD 17308
Query: 131 EPMLTVHQTVSDVR 144
+P VS++R
Sbjct: 17309 KPGPPRDLEVSEIR 17322
Score = 45.4 bits (106), Expect = 2e-04
Identities = 56/291 (19%), Positives = 115/291 (39%), Gaps = 24/291 (8%)
Query: 194 GETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVN 253
G + L +K +D TC + GI L+ + +S + +N
Sbjct: 33089 GSDQTLTIKQASHRDEGILTCISKTKE--GIVKCQYDLTLSKELSDAPAFISQPRSQNIN 33146
Query: 254 PGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGG------TLSIPSVQARDSGYYN 307
G+NV C ++G +P P+++W P+ + + +L I + DSG Y
Sbjct: 33147 EGQNVLFTCEISG-EPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYT 33205
Query: 308 CTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQL-GQDLKLSCHVDAVPQEK 366
A N G + +++ ++ + ++ V++ S + L G S + A QE
Sbjct: 33206 IKAKNFRGQCSATASLMVLPLVEEPSREV---VLRTSGDTSLQGSFSSQSVQMSASKQE- 33261
Query: 367 VTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPD 426
++ F + + M++ + + + ++ S +++ S + M +
Sbjct: 33262 ASFSSFSSSSASSMTEMKFASMSAQSMSSMQESF--VEMSSSSFMGISNMTQLESSTSKM 33319
Query: 427 LSVEVNISSETVPPTI-SVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWS 476
L + +PP I ++P +++ EG + C G+P P V WS
Sbjct: 33320 LKAGIR----GIPPKIEALPSD---ISIDEGKVLTVACAFTGEPTPEVTWS 33363
Score = 45.1 bits (105), Expect = 3e-04
Identities = 42/157 (26%), Positives = 64/157 (40%), Gaps = 33/157 (21%)
Query: 47 VYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQ------ETSVFNETLRIERIAR 100
V T++ GDT+ L+ V G P P+V WTK A+D + +T + + + R
Sbjct: 18210 VLTVKAGDTIRLEAGVRGKPFPEVAWTKDK-DATDLTRSPRVKIDTRADSSKFSLTKAKR 18268
Query: 101 TQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVN 160
+ GG+Y A N G + V LD+P + + DV + RCTV
Sbjct: 18269 SDGGKYVVTATNTAGSFVAYA---TVNVLDKPGPVRNLKIVDVSSD---------RCTVC 18316
Query: 161 SNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETK 197
+PP D G +I + + ETK
Sbjct: 18317 WDPP--------------EDDGGCEIQNYILEKCETK 18339
Score = 44.3 bits (103), Expect = 6e-04
Identities = 28/90 (31%), Positives = 45/90 (50%), Gaps = 7/90 (7%)
Query: 47 VYTIREGDTLMLQCLVTGHPRPQVRWTKTA----GSASDKFQETSVFNETLRIERIARTQ 102
V + G+T +L+ + G P P V W+K +A+ ++++ TL ++ RT
Sbjct: 24716 VIVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTD 24775
Query: 103 GGRYYCKAENGVGVPAIKSIRVDVQYLDEP 132
GG+Y K N V KSI + V+ LD P
Sbjct: 24776 GGQYILKLSN---VGGTKSIPITVKVLDRP 24802
Score = 43.9 bits (102), Expect = 7e-04
Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 6/97 (6%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQ---ETSVFNETLRIERIARTQGGRY 106
+R G T+ L V G P P++ W+K + D+ +++ F+ LR E + + G+Y
Sbjct: 19705 LRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKY 19764
Query: 107 YCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDV 143
EN G K + V+ LD P V+ TV ++
Sbjct: 19765 ILTLENSCGK---KEYTIVVKVLDTPGPPVNVTVKEI 19798
Score = 43.5 bits (101), Expect = 0.001
Identities = 87/390 (22%), Positives = 143/390 (36%), Gaps = 57/390 (14%)
Query: 431 VNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLP 490
+ E PPT+ + R +T+R G L GKP+P V W + EA +L
Sbjct: 16809 ITCKDELAPPTLHLDF-RDKLTIRVGEAFALTGRYSGKPKPKVSWFK--DEADVLEDDRT 16865
Query: 491 LEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSS----- 545
+T L LE++ S + + N R QV + + P V P S
Sbjct: 16866 HIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVT 16925
Query: 546 QDVRQALGRPVL----LRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELR 601
+D +P L + + + + VW PV A+A+ +
Sbjct: 16926 KDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWM---------PVTSASAK----TTCK 16972
Query: 602 LDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQ 661
+ + + N G + L S KA D P+ +++K+ S ++
Sbjct: 16973 VSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKD-SALVT 17031
Query: 662 WTQREPDAVDPVLNYRLSIRQ-LNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR 720
W + D P+ NY L R+ +++ A V P+ K + + DL YE R
Sbjct: 17032 W-NKPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTK-----FRVPDLLEGCQYEFR 17085
Query: 721 LTPYTTFGAGDMA--SRIIHYTEPIN------SPNLSDNTCHFED-----------EKIC 761
++ G GD + S+ + +PI +P D TC+ D KI
Sbjct: 17086 VSAENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKIL 17145
Query: 762 GYTQDL--TDNFDWTRQNALTQNPKRSPNT 789
GY + + +W R N P+ P T
Sbjct: 17146 GYIVEYQKVGDEEWRRAN---HTPESCPET 17172
Score = 43.5 bits (101), Expect = 0.001
Identities = 76/336 (22%), Positives = 125/336 (37%), Gaps = 32/336 (9%)
Query: 422 APVPDLSVEVNISSETVPPTISVPKG-RAVVTVREGSPAELQCEVRGKPRPPVLWSRVDK 480
+P + S V I +E VPP I + ++++TV+ G+ L V GKP P V W K
Sbjct: 19275 SPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWK---K 19331
Query: 481 EAALLPSGLPLEETPDGK---LRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQF 537
+ LL ++ L L V+R SG Y +G + A ++L V
Sbjct: 19332 DGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSG----SKSATIKLKVLD 19387
Query: 538 PPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDH 597
P S + + R +L L I + + + P V A
Sbjct: 19388 KPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPI--- 19444
Query: 598 AELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTP---NPTRSHKLSK 654
++ + + N G +F A A +P +D P +P ++K
Sbjct: 19445 TSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNP---YDPPGRCDPPVISNITK 19501
Query: 655 NYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYIL--TDLR 712
++ V W D P+ Y L R+ +A+ +V + ++E L T L+
Sbjct: 19502 DHMTV-SWKPPADDGGSPITGYLLEKRE-------TQAVNWTKVNRKPIIERTLKATGLQ 19553
Query: 713 VPHSYEVRLTPYTTFGAG--DMASRIIHYTEPINSP 746
YE R+T G G AS+ + +P P
Sbjct: 19554 EGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPP 19589
Score = 43.1 bits (100), Expect = 0.001
Identities = 37/125 (29%), Positives = 54/125 (43%), Gaps = 11/125 (8%)
Query: 15 HCRGQG----VYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQV 70
+C GQG + P QA+ + +A + D + G+ + + G P P V
Sbjct: 27246 NCAGQGEPIEMNEPVQAKDIL--EAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTV 27303
Query: 71 RWTK---TAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQ 127
W K GS + E + + L I ++ R G+Y ENGVG P KS V V+
Sbjct: 27304 TWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEP--KSSTVSVK 27361
Query: 128 YLDEP 132
LD P
Sbjct: 27362 VLDTP 27366
Score = 43.1 bits (100), Expect = 0.001
Identities = 48/203 (23%), Positives = 78/203 (38%), Gaps = 20/203 (9%)
Query: 46 RVYTIREGDTLMLQCLVTGHPRPQVRWTK-----TAGSASDKFQETSVFNETLRIERIAR 100
R +R L C VTGHP+P V+W + A + QE L I +
Sbjct: 30935 RNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTD 30994
Query: 101 TQGGRYYCKAEN-GVGVPAIKSIRVDVQYLDEPMLTVH--QTVSDVRGNFYQEKTVFLRC 157
Y +A N G V S+ V+V T+ V +RG + V ++
Sbjct: 30995 DDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRG-----EVVSIKI 31049
Query: 158 TVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVS 217
+ P W++G D + +NG Y+ + T+ T ++ + +D Y V
Sbjct: 31050 PFSGKPDPVITWQKGQDLI---DNNG--HYQVIVTRSFTSLVFPNGVERKDAGFYV--VC 31102
Query: 218 VRNVCGIPDKAITFRLTNTTAPP 240
+N GI K + + + PP
Sbjct: 31103 AKNRFGIDQKTVELDVADVPDPP 31125
Score = 42.7 bits (99), Expect = 0.002
Identities = 69/392 (17%), Positives = 141/392 (35%), Gaps = 50/392 (12%)
Query: 343 ESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLEL 402
E + + D SC + +EK +W++NG+ + K+ ++ L +
Sbjct: 12830 EDQTVTEFDDAVFSCQLS---REKANVKWYRNGREIKEGKKYKFEKDGS-----IHRLII 12881
Query: 403 IDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQ 462
D D Y C V D + E +P I P + G+
Sbjct: 12882 KDCRLDDECEYAC-------GVEDRKSRARLFVEEIPVEIIRPPQD--ILEAPGADVVFL 12932
Query: 463 CEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGF 522
E+ K + V W R + + E +L++ + G YR F
Sbjct: 12933 AELN-KDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYR--------F 12983
Query: 523 NVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLL 582
+ +EA+ +L + P+++ + QD+ +G+P+ + ++ A A W + + L
Sbjct: 12984 IAKDKEARAKLELAAAPKIKTADQDLVVDVGKPLTM---VVPYDAYPKAEAEWFKENEPL 13040
Query: 583 PPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFD 642
+ A + R+ + G Y+ + N G A + D
Sbjct: 13041 STKTIDTTA----EQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKV--------ID 13088
Query: 643 TPNPTRSHKLSKNY--SYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEK 700
P P R+ ++++ + L W + D ++ Y + R + + V+ ++
Sbjct: 13089 VPGPVRNLEVTETFDGEVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVL------ATDR 13142
Query: 701 GQLLEYILTDLRVPH-SYEVRLTPYTTFGAGD 731
+ E+ +T L+ Y R++ G G+
Sbjct: 13143 AESCEFTVTGLQKGGVEYLFRVSARNRVGTGE 13174
Score = 42.7 bits (99), Expect = 0.002
Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 4/89 (4%)
Query: 45 ERVYTIREGDTLMLQCLVTGHPRPQVRWTKTA-GSASDKFQETSVFNETLRIERIARTQG 103
++ TIR G +L L V+G P P + W+K AS +T+ L ++++ R
Sbjct: 29453 KKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDA 29512
Query: 104 GRYYCKAENGVGVPAIKSIRVDVQYLDEP 132
G+Y +AEN G KS V V+ D P
Sbjct: 29513 GKYTIEAENQSGK---KSATVLVKVYDTP 29538
Score = 42.4 bits (98), Expect = 0.002
Identities = 39/135 (28%), Positives = 59/135 (43%), Gaps = 20/135 (14%)
Query: 13 PFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRW 72
P CR + YAP +A++ + + + TIR G L+L V G P P++ W
Sbjct: 29034 PVTCRDE--YAPPKAEL----------DARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIW 29081
Query: 73 TKTAGSASDKFQETSV----FNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQY 128
TK D ++ S+ T I+ R+ G+Y +N G K++ V V+
Sbjct: 29082 TK-GDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGT---KAVSVMVKV 29137
Query: 129 LDEPMLTVHQTVSDV 143
LD P TVS V
Sbjct: 29138 LDSPGPCGKLTVSRV 29152
Score = 42.4 bits (98), Expect = 0.002
Identities = 44/170 (25%), Positives = 71/170 (41%), Gaps = 17/170 (10%)
Query: 228 AITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPL----- 282
+I +LT+ AP K + T + GE + C + G PLP ++W L
Sbjct: 30522 SIKTKLTSGEAPGIRKEMKDVTTKL--GEAAQLSCQIVGR-PLPDIKWYRFGKELIQSRK 30578
Query: 283 -PLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDV- 340
+ + + TL++ + + D G Y C ATN VG + LL AT Q P
Sbjct: 30579 YKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLL-----QATPQFHPGYP 30633
Query: 341 IKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRND 390
+KE +G L+L HV + + WF K + S+ + + +
Sbjct: 30634 LKEKYYGAVGSTLRL--HVMYIGRPVPAMTWFHGQKLLQNSENITIENTE 30681
Score = 42.4 bits (98), Expect = 0.002
Identities = 91/433 (21%), Positives = 145/433 (33%), Gaps = 115/433 (26%)
Query: 224 IPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLP 283
+ +K+ T ++ T A A L+ ++ V GE+ C T G+P+P + W L
Sbjct: 32546 LEEKSTTRKIKTTLA--ARILTKPRSMTVYEGESARFSCD-TDGEPVPTVTWLRKGQVLS 32602
Query: 284 LGALAQ------GGTLSIPSVQARDSGYYNCTATNNVGNP-------------AKKTVNL 324
A Q T I SVQA D G Y+ N+ G +K V
Sbjct: 32603 TSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTS 32662
Query: 325 LVRSMKNATFQITPDVIKESENI---------------------------------QLGQ 351
R +P+ +K + + ++ Q
Sbjct: 32663 PPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQ 32722
Query: 352 DLK---------LSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLEL 402
LK L+C V++ W+K+GK + + + T L++
Sbjct: 32723 FLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADG----TYELKI 32778
Query: 403 IDLHFSDYGTYLCMAS-----------FPGAPVPDLSVEVNISSET-------------- 437
+L SD G Y+C S F G + +V+ SET
Sbjct: 32779 NNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTR 32838
Query: 438 -----VPPTIS----VPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSG 488
P IS + G TV S A+ + G+PRP +W++ D +A
Sbjct: 32839 KTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTK-DGKAITQGGK 32897
Query: 489 LPLEETPDG-KLRLERVSRDMSGTYRCQTARYNGF----------NVRPREAQVQLNVQF 537
L E G L + + SG Y C G ++ EAQ +++ Q
Sbjct: 32898 YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQ-KVSTQK 32956
Query: 538 PPEVEPSSQDVRQ 550
E+ P + V Q
Sbjct: 32957 TSEITPQKKAVVQ 32969
Score = 42.0 bits (97), Expect = 0.003
Identities = 53/219 (24%), Positives = 88/219 (40%), Gaps = 18/219 (8%)
Query: 152 TVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYAS 211
T ++ P W R +S S GV I ++ G K L + + +
Sbjct: 22 TATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQIS---FSDGRAK-LTIPAVTKANSGR 77
Query: 212 YTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLP 271
Y+ + + N G + TAPP + +++ V G V +Q +TG P P
Sbjct: 78 YSLKAT--NGSGQATSTAELLVKAETAPPNFVQRL-QSMTVRQGSQVRLQVRVTG-IPTP 133
Query: 272 QLQWSHGPGPLPLGA---LAQGG---TLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLL 325
+++ + ++Q G +L I DSG Y+ ATN+VG A T LL
Sbjct: 134 VVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGR-ATSTAELL 192
Query: 326 VRSMKNATFQITPDVIKE---SENIQLGQDLKLSCHVDA 361
V+ + + T ++ SE+ Q + K+ H DA
Sbjct: 193 VQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDA 231
Score = 42.0 bits (97), Expect = 0.003
Identities = 90/376 (23%), Positives = 140/376 (37%), Gaps = 70/376 (18%)
Query: 152 TVFLRCTVNSNPPARFIW-KRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYA 210
T L C V S A+ W K G++ L + YE + G + L + + P+D
Sbjct: 12301 TAVLECEV-SRENAKVKWFKNGTEILKSKK------YE-IVADGRVRKLVIHDCTPEDIK 12352
Query: 211 SYTCQV-SVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDP 269
+YTC + C + N P L L V E +C L+ +
Sbjct: 12353 TYTCDAKDFKTSCNL----------NVVPPHVEFLRPLTDLQVREKEMARFECELSREN- 12401
Query: 270 LPQLQWSHGPGPLPLG----ALAQGGT--LSIPSVQARDSGYYNCTATNNVGNPAKKTVN 323
+++W + G +++G L I D Y+C +T
Sbjct: 12402 -AKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVR------TARTSG 12454
Query: 324 LLVRSMKNATFQITPDVIKESENIQLGQ--DLKLSCHVDAVPQEKVTYQWFKNGKPARMS 381
+L + A F K NI++ + +KL C V E + W+K + +
Sbjct: 12455 MLTVLEEEAVF------TKNLANIEVSETDTIKLVCEVSKPGAEVI---WYKGDEEIIET 12505
Query: 382 KRL-LVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPP 440
R ++T + L + + H D G Y C P + D V+V+ E
Sbjct: 12506 GRYEILTEGRKRI------LVIQNAHLEDAGNYNC--RLPSSRT-DGKVKVH---ELAAE 12553
Query: 441 TISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLR 500
IS P+ + + EG AE C + K PV W R DK L SG + DGK R
Sbjct: 12554 FISKPQN---LEILEGEKAEFVCSI-SKESFPVQWKRDDK---TLESGDKYDVIADGKKR 12606
Query: 501 L----ERVSRDMSGTY 512
+ + +DM GTY
Sbjct: 12607 VLVVKDATLQDM-GTY 12621
Score = 41.2 bits (95), Expect = 0.005
Identities = 77/352 (21%), Positives = 120/352 (34%), Gaps = 70/352 (19%)
Query: 430 EVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGL 489
EV + + P + + K V+TV+ G L+ VRGKP P V W++ DK+A L
Sbjct: 18191 EVVVKEDLQKPVLDL-KLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTK-DKDATDLTRSP 18248
Query: 490 PLE---ETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV----- 541
++ K L + R G Y G V A +NV P
Sbjct: 18249 RVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFV----AYATVNVLDKPGPVRNLK 18304
Query: 542 -------------EPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW-RFKGQLLPPPPV 587
+P D + +L +C R VW + +L P
Sbjct: 18305 IVDVSSDRCTVCWDPPEDDGGCEIQNYILEKCETKR--------MVWSTYSATVLTPGTT 18356
Query: 588 VPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFD---TP 644
V E ++ + N +G+ +K + +D P
Sbjct: 18357 VTRLIEGNEYI--------------FRVRAENKIGTGP---PTESKPVIAKTKYDKPGRP 18399
Query: 645 NPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAV---VKAIPVRRVEKG 701
+P K+SK V+ W E D + Y L ++ + V AIP RR++
Sbjct: 18400 DPPEVTKVSKEEMTVV-WNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERRMKVQ 18458
Query: 702 QLLEYILTDLRVPHSYEVRLTPYTTFGAGD--MASRIIHYTEPINSPNLSDN 751
LL H Y+ R+ G G+ + SR + +PI P N
Sbjct: 18459 NLLP--------DHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTN 18502
Score = 40.8 bits (94), Expect = 0.006
Identities = 61/262 (23%), Positives = 98/262 (37%), Gaps = 49/262 (18%)
Query: 93 LRIERIARTQGGRYYCKAENGVGVPA------IKSIR-VDVQYLDEPMLTVHQTVSDVR- 144
L ++ I + G Y CK N G + +K +R V Y M + + +R
Sbjct: 31626 LYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRL 31685
Query: 145 -------------GNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEP-- 189
Y + V T+ +P W + + ++ +E
Sbjct: 31686 LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDK 31745
Query: 190 -LYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVN- 247
LY L + ++ D A YT V RN G + + +LT T PP ++
Sbjct: 31746 GLYQ------LTINSVTTDDDAEYT--VVARNKYG--EDSCKAKLTVTLHPPPTDSTLRP 31795
Query: 248 --ETLVVNP----GENVTVQCLLTGGDPLPQLQWSHGPGPLPLGA----LAQG---GTLS 294
+ L+ N G++V + ++G P P L+W PL LG + +G L
Sbjct: 31796 MFKRLLANAECQEGQSVCFEIRVSGIPP-PTLKWEKDGQPLSLGPNIEIIHEGLDYYALH 31854
Query: 295 IPSVQARDSGYYNCTATNNVGN 316
I D+GYY TATN G+
Sbjct: 31855 IRDTLPEDTGYYRVTATNTAGS 31876
Score = 40.0 bits (92), Expect = 0.010
Identities = 50/198 (25%), Positives = 77/198 (38%), Gaps = 26/198 (13%)
Query: 350 GQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVT------RNDPELPAVTSSLELI 403
G H+ P +V+ WF++G+ S V R +PAVT +
Sbjct: 20 GSTATFEAHISGFPVPEVS--WFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKA---- 73
Query: 404 DLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQC 463
+ G Y A+ G+ + E+ + +ET PP + +TVR+GS LQ
Sbjct: 74 -----NSGRYSLKAT-NGSGQATSTAELLVKAETAPPNFV--QRLQSMTVRQGSQVRLQV 125
Query: 464 EVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDG---KLRLERVSRDMSGTYRCQTARYN 520
V G P P V + R + A + S L + + +G L + + SGTY
Sbjct: 126 RVTGIPTPVVKFYR---DGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSV 182
Query: 521 GFNVRPREAQVQLNVQFP 538
G E VQ + P
Sbjct: 183 GRATSTAELLVQGEEEVP 200
Score = 40.0 bits (92), Expect = 0.010
Identities = 34/126 (26%), Positives = 59/126 (46%), Gaps = 18/126 (14%)
Query: 208 DYASYTCQVSVRNVCGIPDKAITFRLT--NTTAPPALKLSVN---ETLVVNPGENVTVQC 262
++ Y +V N G + ++ + + PP +KL ++ +T+ V GE V +
Sbjct: 15361 EHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPA 15420
Query: 263 LLTGGDPLPQLQWSHGPGPL--PLGAL---------AQGGT-LSIPSVQARDSGYYNCTA 310
+TG P+P+++WS + P AL ++ T LSIP D G Y TA
Sbjct: 15421 DVTGL-PMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTA 15479
Query: 311 TNNVGN 316
+N +G+
Sbjct: 15480 SNRLGS 15485
Score = 40.0 bits (92), Expect = 0.010
Identities = 33/117 (28%), Positives = 52/117 (44%), Gaps = 3/117 (2%)
Query: 426 DLSVEVNISSETVPPTISV-PKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAAL 484
D S + E P S+ PK + V+ V G L+ ++RGKP P V+WS+ KE
Sbjct: 24691 DSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKELEE 24750
Query: 485 LPSGLPLEET-PDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE 540
+ + ++ T L ++ R G Y + + G P +V L+ PPE
Sbjct: 24751 TAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKV-LDRPGPPE 24806
Score = 40.0 bits (92), Expect = 0.010
Identities = 100/456 (21%), Positives = 172/456 (37%), Gaps = 55/456 (12%)
Query: 239 PPALKLSVNETLVVNPGENVTVQCLLT-GGDPLPQLQWSHGPGPLP----LGALAQGGTL 293
PP ++L + VV + T++ +T G P P+++W G L + + L
Sbjct: 25104 PPEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTML 25163
Query: 294 SIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDL 353
I +V DSG YN T NN G+ VN+ V +A +T +K+ +++ L +
Sbjct: 25164 VIDNVTRFDSGRYNLTLENNSGSKT-AFVNVRVLDSPSAPVNLTIREVKK-DSVTLSWEP 25221
Query: 354 KLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTY 413
L +D K+T + + R + +T N T +E + S Y
Sbjct: 25222 PL---IDG--GAKITNYIVEKRETTRKA-YATITNN---CTKTTFRIENLQEGCSYYFRV 25272
Query: 414 LCMASFPGAPVPDLSVE-VNISSETVPP--TISVPKGRAVVTVREGSPAE---------- 460
L + G +P + E V +S +PP V R T++ P
Sbjct: 25273 LASNEY-GIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYV 25331
Query: 461 LQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYN 520
++ + +G + WS + L + L + R+ V+ R
Sbjct: 25332 VEMQTKGSEK----WSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGR-----SDPRQL 25382
Query: 521 GFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQ 580
G V R+ +++ +V+ P + R+ L V +G PQ A+ WR GQ
Sbjct: 25383 GVPVIARDIEIKPSVELP--FHTFNVKAREQLKIDV-----PFKGRPQ--ATVNWRKDGQ 25433
Query: 581 LLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFY 640
L V ++ + L + +++ G+YE VSN GS +
Sbjct: 25434 TLKETTRVNVSS-SKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRP---- 25488
Query: 641 FDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNY 676
P P R ++S + S + W E D + NY
Sbjct: 25489 -GPPGPIRIDEVSCD-SITISWNPPEYDGGCQISNY 25522
Score = 39.7 bits (91), Expect = 0.014
Identities = 64/286 (22%), Positives = 103/286 (36%), Gaps = 29/286 (10%)
Query: 451 VTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLP--LEETPDG--KLRLERVSR 506
+ VR S A L C+V G P+P V W R KE ++ GL ++E G +L + V+
Sbjct: 30937 LNVRYQSNATLVCKVTGHPKPIVKWYRQGKE--IIADGLKYRIQEFKGGYHQLIIASVTD 30994
Query: 507 DMSGTYRCQTARYNG--FNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLR 564
D + Y+ + G E +V + P +E V G V ++
Sbjct: 30995 DDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGA-VHALRGEVVSIKIP-FS 31052
Query: 565 GSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSA 624
G P + + W+ L+ + + + V R +G Y N G
Sbjct: 31053 GKPDPVIT--WQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGID 31110
Query: 625 ACLFQVSAKAYSPEFYFDTPNPTRSHKLS--KNYSYVLQWTQREPDAVDPVLNYRLSIRQ 682
++ D P+P R K+S S L WT+ D + NY +
Sbjct: 31111 QKTVELDVA--------DVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIV---- 31158
Query: 683 LNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFG 728
A RV + + Y + +L SY+ R+ FG
Sbjct: 31159 ---EKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFG 31201
Score = 39.3 bits (90), Expect = 0.018
Identities = 31/120 (25%), Positives = 49/120 (40%), Gaps = 11/120 (9%)
Query: 207 QDYASYTCQVSVRNVCGI--PDKAITFRLTNTTAPPALKLSVN--ETLVVNPGENVTVQC 262
Q +Y +V N+ G+ PD I PP+++L V E LVV G V
Sbjct: 17473 QQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPA 17532
Query: 263 LLTGGDPLPQLQWSHGPGPLPLGALAQ------GGTLSIPSVQARDSGYYNCTATNNVGN 316
++ G P+P +W+ + L+I + RD+G Y T +N G+
Sbjct: 17533 IIR-GVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGS 17591
Score = 38.9 bits (89), Expect = 0.023
Identities = 41/176 (23%), Positives = 79/176 (44%), Gaps = 24/176 (13%)
Query: 248 ETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGAL-------AQG-GTLSIPSVQ 299
+++VV G T + ++G P+P++ W + L + G L+IP+V
Sbjct: 13 QSVVVLEGSTATFEAHISGF-PVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVT 71
Query: 300 ARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIK--ESENIQLGQDLKLSC 357
+SG Y+ ATN G A T LLV++ P+ ++ +S ++ G ++L
Sbjct: 72 KANSGRYSLKATNGSGQ-ATSTAELLVKAE-----TAPPNFVQRLQSMTVRQGSQVRLQV 125
Query: 358 HVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTY 413
V +P V +++++G + S +++ SL + + + D GTY
Sbjct: 126 RVTGIPTPVV--KFYRDGAEIQSSLDFQISQEGD-----LYSLLIAEAYPEDSGTY 174
Score = 38.9 bits (89), Expect = 0.023
Identities = 101/471 (21%), Positives = 164/471 (34%), Gaps = 78/471 (16%)
Query: 41 DNISERVYTIREGDTLMLQCLVTGHPRPQVRWTK-----TAGSASDKFQETSVFNETLRI 95
D ++ +R G + L +V G P P+V W K +T F L I
Sbjct: 18609 DASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAF---LVI 18665
Query: 96 ERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFL 155
R G+Y N G K++ V+V+ LD P VSDV KT
Sbjct: 18666 PNSTRDDSGKYSLTLVNPAGE---KAVFVNVRVLDTPGPVSDLKVSDV------TKT--- 18713
Query: 156 RCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQ 215
C V+ PP + + + ++ + + + + + NL P + Y +
Sbjct: 18714 SCHVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGN--EYYFR 18771
Query: 216 VSVRNVCG------IPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDP 269
V+ N G +P + + PP KL V E + N + L GG
Sbjct: 18772 VTAVNEYGPGVPTDVPKPVLASDPLSEPDPPR-KLEVTE-MTKNSATLAWLPPLRDGGAK 18829
Query: 270 LPQLQWSHGPGPLPLG-----ALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNL 324
+ S+ P ++ + +L + ++ + A N VG +
Sbjct: 18830 IDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPRE--- 18886
Query: 325 LVRSMKNATFQITPD--VIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSK 382
+ A Q+ P ++ E I+ G+ L++ HV P T +W K S
Sbjct: 18887 -AEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHP--TCKWKKGEDEVVTSS 18943
Query: 383 RLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTI 442
L V + D +S L + D+ D G Y S+ SS T I
Sbjct: 18944 HLAVHKADS-----SSILIIKDVTRKDSGYY--------------SLTAENSSGTDTQKI 18984
Query: 443 SVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEE 493
V + + G P+PP S +D +A L +PLE+
Sbjct: 18985 KV----------------VVMDAPGPPQPPFDISDIDADACSLSWHIPLED 19019
Score = 38.9 bits (89), Expect = 0.023
Identities = 149/784 (19%), Positives = 275/784 (35%), Gaps = 110/784 (14%)
Query: 19 QGVYAPAQAQI-VHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAG 77
+G+ P Q + V A + + +T+ G+ L + G P P V W K
Sbjct: 22127 KGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNV 22186
Query: 78 SASDKFQ---ETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPML 134
+ E++ N L I+ R G Y K N G AI+++ V V LD+P
Sbjct: 22187 PLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAG-EAIETLNVIV--LDKP-- 22241
Query: 135 TVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQG 194
G ++ T++ PP ++ + +D ++ +
Sbjct: 22242 ------GPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTSTTTWQIVSATV 22295
Query: 195 ETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNP 254
+K L+ Y +++ N G K+ T A K+ P
Sbjct: 22296 ARTTIKACRLKTG--CEYQFRIAAENRYG---KSTYLNSEPTVAQYPFKV---------P 22341
Query: 255 GENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIP-SVQARDSGYYNCTATNN 313
G T L+ D + ++QW+ ++ GG+ I ++ ++ N
Sbjct: 22342 GPPGTPVVTLSSRDSM-EVQWNE--------PISDGGSRVIGYHLERKERNSILWVKLNK 22392
Query: 314 VGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLS-CHVDAVP--------- 363
P K + F+++ + I + +G+ K+S C+V P
Sbjct: 22393 TPIPQTKFKTTGLEEGVEYEFRVSAENI-----VGIGKPSKVSECYVARDPCDPPGRPEA 22447
Query: 364 ----QEKVTYQWFKNGKP--ARMSKRLLVTRNDPELPAVTSSL-ELIDLHFS-------- 408
+ VT QW K ++++ ++ + PE + +S +ID HF
Sbjct: 22448 IIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDH 22507
Query: 409 --DYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISV-PKGRAVVTVREGSPAELQCEV 465
++ A+ + + + + E PP IS+ PK + + V G ++ ++
Sbjct: 22508 RYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADI 22567
Query: 466 RGKPRPPVLWSRVDKEAALLPSGLPLEETPDG-KLRLERVSRDMSGTYRCQTARYNGFNV 524
GKP P + W + D+E + + L ++ T L ++ R SG Y + G
Sbjct: 22568 YGKPIPTIQWIKGDQELS-NTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAG--- 22623
Query: 525 RPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSP-QRIASAVWRFKGQLLP 583
E V +NV+ P V + +C+L P Q S + + +
Sbjct: 22624 ---ERSVTVNVKVLDRPGPPEGPV--VISGVTAEKCTLAWKPPLQDGGSDIINYIVERRE 22678
Query: 584 PPPVVPAAAEA-PDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFD 642
+V +A ++ + + ++ N G L A +P D
Sbjct: 22679 TSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPD 22738
Query: 643 TPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRL------SIRQLNQHNAVVKAIPVR 696
P ++K+ S ++ W + D +L Y L IR H ++ + +R
Sbjct: 22739 APKAPEVTTVTKD-SMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLR 22797
Query: 697 RVEKGQLLEYILTDLRVPHSYEVRLTPYTTFG--------AGDMASRIIHYTEPINSPNL 748
+T L H YE R++ G A A I+ P N+P +
Sbjct: 22798 -----------VTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKV 22846
Query: 749 SDNT 752
D T
Sbjct: 22847 IDIT 22850
Score = 38.9 bits (89), Expect = 0.023
Identities = 49/230 (21%), Positives = 85/230 (36%), Gaps = 57/230 (24%)
Query: 191 YTQGETKVLKLKNLRPQDYASYTCQVS--------------------------VRNVCGI 224
Y+ T LK+ NL D Y C++S +
Sbjct: 32768 YSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKS 32827
Query: 225 PDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQ-------CLLTGGDPLPQLQWSH 277
K +T T P A + ++ ++V ++ TV + G+P P W+
Sbjct: 32828 DQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTK 32887
Query: 278 GPGPLPLGALAQ------GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKN 331
+ G + G L I DSG Y CT N+ G+ + L ++++K+
Sbjct: 32888 DGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGS-VSSSCKLTIKAIKD 32946
Query: 332 A---------TFQITPD---VIKE--SENIQLGQDLKLSCHVDAVPQEKV 367
T +ITP V++E S+ +++K+S +A QEK+
Sbjct: 32947 TEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMS---EAKSQEKL 32993
Score = 38.5 bits (88), Expect = 0.030
Identities = 28/99 (28%), Positives = 42/99 (42%), Gaps = 8/99 (8%)
Query: 38 VKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE----TL 93
V+ D V T+R G T+ + V G P P + WTK G + + + + L
Sbjct: 17908 VELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTK-EGKVLVREKRVDLIQDLPRVEL 17966
Query: 94 RIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEP 132
+I+ R G+Y A+N G +I V LD P
Sbjct: 17967 QIKEAVRADHGKYIISAKNSSGHAQGSAI---VNVLDRP 18002
Score = 38.5 bits (88), Expect = 0.030
Identities = 21/57 (36%), Positives = 28/57 (49%), Gaps = 1/57 (1%)
Query: 426 DLSVEVNISSETVPPTISV-PKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKE 481
D + + E P IS+ PK R + V G L+ +V GKP P + W R DKE
Sbjct: 23609 DSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKE 23665
Score = 38.5 bits (88), Expect = 0.030
Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 8/87 (9%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTK----TAGSASDKFQETSVFNETLRIERIARTQGGR 105
+ G+T L+ V G P P + W + SA + + T F L ++ R GG+
Sbjct: 23637 VNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTD-FKALLIVKDAIRIDGGQ 23695
Query: 106 YYCKAENGVGVPAIKSIRVDVQYLDEP 132
Y +A N V KS V+V+ LD P
Sbjct: 23696 YILRASN---VAGSKSFPVNVKVLDRP 23719
Score = 38.5 bits (88), Expect = 0.030
Identities = 65/330 (19%), Positives = 110/330 (33%), Gaps = 50/330 (15%)
Query: 344 SENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELI 403
S + G+ + SC D P VT W + G+ S R VT + S+ E+
Sbjct: 32569 SMTVYEGESARFSCDTDGEPVPTVT--WLRKGQVLSTSARHQVTTTKYK-----STFEIS 32621
Query: 404 DLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQC 463
+ SD G Y + VE + + T+++ K R P
Sbjct: 32622 SVQASDEGNY------------SVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSP 32669
Query: 464 EVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFN 523
E R K EA P + E K +S T T
Sbjct: 32670 EPRVK----------SPEAVKSPKRVKSPEPSHPKA--------VSPTETKPT------- 32704
Query: 524 VRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLP 583
P E L V PP++ +Q ++ + + ++ S R W G+ L
Sbjct: 32705 --PTEKVQHLPVSAPPKI---TQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLK 32759
Query: 584 PPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDT 643
A EL+++ +T G Y C +S + G++ Q +A+ +
Sbjct: 32760 ENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFK-SIHEKV 32818
Query: 644 PNPTRSHKLSKNYSYVLQWTQREPDAVDPV 673
+ + K + + + EP A +P+
Sbjct: 32819 SKISETKKSDQKTTESTVTRKTEPKAPEPI 32848
Score = 38.1 bits (87), Expect = 0.040
Identities = 29/115 (25%), Positives = 46/115 (40%), Gaps = 8/115 (6%)
Query: 429 VEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSG 488
V + PPT+ G VTV EG L+C + G P P V W R D + + S
Sbjct: 932 VPAPVEIPVTPPTLV--SGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQ---IESS 986
Query: 489 LPLE---ETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE 540
+ + ++ +L + + SG + C G VQ++ +F E
Sbjct: 987 IDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKE 1041
Score = 38.1 bits (87), Expect = 0.040
Identities = 36/133 (27%), Positives = 52/133 (39%), Gaps = 20/133 (15%)
Query: 212 YTCQVSVRNVCGIPDKAITFR---LTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGD 268
Y +V N G+ + T PP++ L E + V G NV + + G
Sbjct: 16087 YEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLK--EFMEVEEGTNVNIVAKIKGV- 16143
Query: 269 PLPQLQWSHGPGPLPLG-------------ALAQGGTLSIPSVQARDSGYYNCTATNNVG 315
P P L W P P + TL IP + D+G Y TA NN+G
Sbjct: 16144 PFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLG 16203
Query: 316 NPAKK-TVNLLVR 327
+K+ +N+L R
Sbjct: 16204 TASKEMRLNVLGR 16216
Score = 38.1 bits (87), Expect = 0.040
Identities = 66/268 (24%), Positives = 105/268 (39%), Gaps = 48/268 (17%)
Query: 92 TLRIERIARTQGGRYYCK--AENGVGV-PAI--KSIRVDVQYLDEPMLTVHQTVSDVRGN 146
T R+ + YY + AEN VGV P I K+ + + +D P + ++D
Sbjct: 18056 TKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKT 18115
Query: 147 FYQEKTVFLRCTVNSNPPARFIWKR-----GSDTLSHSQDN---GVDIYEPLYTQGETKV 198
F V+L+ W+R GS LS+ + G D +E ++ +G K
Sbjct: 18116 F-----VYLK------------WRRPDYDGGSPNLSYHVERRLKGSDDWERVH-KGSIKE 18157
Query: 199 LKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLT--NTTAPPALKLSVNETLVVNPGE 256
R + Y +V +N G D T + P L L ++ L V G+
Sbjct: 18158 THYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGD 18217
Query: 257 NVTVQCLLTGGDPLPQLQWSHGPGPLPL--------GALAQGGTLSIPSVQARDSGYYNC 308
+ ++ + G P P++ W+ L A S+ + D G Y
Sbjct: 18218 TIRLEAGVRG-KPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVV 18276
Query: 309 TATNNVGN-PAKKTVNLL-----VRSMK 330
TATN G+ A TVN+L VR++K
Sbjct: 18277 TATNTAGSFVAYATVNVLDKPGPVRNLK 18304
Score = 38.1 bits (87), Expect = 0.040
Identities = 34/133 (25%), Positives = 52/133 (39%), Gaps = 16/133 (12%)
Query: 600 LRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSK--NYS 657
L ++ R+ SG Y ++ N + +A+ V DTP P + + S
Sbjct: 26242 LTIENANRNDSGKYTLTIQNVLSAASLTLVVKV--------LDTPGPPTNITVQDVTKES 26293
Query: 658 YVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSY 717
VL W E D PV NY + R+ + K V L Y +T+L+ Y
Sbjct: 26294 AVLSWDVPENDGGAPVKNYHIEKREAS------KKAWVSVTNNCNRLSYKVTNLQEGAIY 26347
Query: 718 EVRLTPYTTFGAG 730
R++ FG G
Sbjct: 26348 YFRVSGENEFGVG 26360
Score = 38.1 bits (87), Expect = 0.040
Identities = 26/89 (29%), Positives = 39/89 (43%), Gaps = 4/89 (4%)
Query: 45 ERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQ-ETSVFNETLRIERIARTQG 103
++ + +R G ++ L G P P W+K + S + T+ TL +E R
Sbjct: 28364 KQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDA 28423
Query: 104 GRYYCKAENGVGVPAIKSIRVDVQYLDEP 132
G+Y EN G KSI V+ LD P
Sbjct: 28424 GKYTLTVENNSG---SKSITFTVKVLDTP 28449
Score = 37.7 bits (86), Expect = 0.052
Identities = 26/75 (34%), Positives = 36/75 (48%), Gaps = 2/75 (2%)
Query: 439 PPTISVPKG-RAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDG 497
PP I + R +V VR G P L VRG+P P V W +V + + + L +T
Sbjct: 18603 PPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTM-A 18661
Query: 498 KLRLERVSRDMSGTY 512
L + +RD SG Y
Sbjct: 18662 FLVIPNSTRDDSGKY 18676
Score = 37.4 bits (85), Expect = 0.067
Identities = 35/146 (23%), Positives = 60/146 (41%), Gaps = 16/146 (10%)
Query: 417 ASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWS 476
AS P P ++ + ++ P K A +TV+ G+ EL V GKP P + W+
Sbjct: 13669 ASKPSRPTEEIQA---VDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWT 13725
Query: 477 RVD----KEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQ 532
+ D ++ + +P + T + + R +GTY + G A V+
Sbjct: 13726 KADMILKQDKRITIENVPKKST----VTIVDSKRSDTGTYIIEAVNVCG----RATAVVE 13777
Query: 533 LNVQFPPEVEPSSQDVRQALGRPVLL 558
+NV P P++ D+ LL
Sbjct: 13778 VNVLDKPG-PPAAFDITDVTNESCLL 13802
Score = 37.4 bits (85), Expect = 0.067
Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 2/59 (3%)
Query: 421 GAPVPDLSVEVNISSETVPPTISVPKGRA--VVTVREGSPAELQCEVRGKPRPPVLWSR 477
G P L + V I + VPPTI + + V+ G P + +V G P P + WS+
Sbjct: 15376 GESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSK 15434
Score = 37.4 bits (85), Expect = 0.067
Identities = 41/185 (22%), Positives = 70/185 (37%), Gaps = 16/185 (8%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTK-TAGSASDKFQETSVFNETLRIERI--ARTQGGR 105
TIR G+ L +G P+P+V W K A D TL +E+I R+ G+
Sbjct: 16829 TIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGK 16888
Query: 106 YYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPA 165
Y EN G + V +D P V D Y ++ PP
Sbjct: 16889 YCVVVENSTG---SRKGFCQVNVVDRPGPPVGPVSFDEVTKDYM--------VISWKPPL 16937
Query: 166 RFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIP 225
+ ++ + ++ G D++ P+ + K+ L + Y ++ N+ GI
Sbjct: 16938 DDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKL--LEGKDYIFRIHAENLYGIS 16995
Query: 226 DKAIT 230
D ++
Sbjct: 16996 DPLVS 17000
Score = 37.4 bits (85), Expect = 0.067
Identities = 38/131 (29%), Positives = 56/131 (42%), Gaps = 18/131 (13%)
Query: 210 ASYTCQVSVRNVCGI------PDKAITFRLTNTTAPPALKLSVN--ETLVVNPGENVTVQ 261
A+Y +V +N G P AIT R + P +K+ V +T+++ GE ++
Sbjct: 21425 AAYEFRVIAKNAAGAISPPSEPSDAITCR--DDVEAPKIKVDVKFKDTVILKAGEAFRLE 21482
Query: 262 CLLTGGDPLPQLQWS------HGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVG 315
++G P P ++WS G L + L RDSG Y TAT N G
Sbjct: 21483 ADVSGRPP-PTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTAT-NPG 21540
Query: 316 NPAKKTVNLLV 326
AK N+ V
Sbjct: 21541 GFAKHIFNVKV 21551
Score = 37.4 bits (85), Expect = 0.067
Identities = 16/35 (45%), Positives = 22/35 (62%)
Query: 450 VVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAAL 484
+VT+R GS L V GKP P ++W++ DKE L
Sbjct: 29056 LVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDL 29090
Score = 37.0 bits (84), Expect = 0.088
Identities = 31/120 (25%), Positives = 50/120 (41%), Gaps = 14/120 (11%)
Query: 20 GVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTK----- 74
GV P +A+ V+ + ++ + TI+ G L ++ V G P P +W K
Sbjct: 18880 GVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEV 18939
Query: 75 --TAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEP 132
++ A K +S+ L I+ + R G Y AEN G K + V +D P
Sbjct: 18940 VTSSHLAVHKADSSSI----LIIKDVTRKDSGYYSLTAENSSGTDTQK---IKVVVMDAP 18992
Score = 36.6 bits (83), Expect = 0.11
Identities = 40/180 (22%), Positives = 72/180 (40%), Gaps = 19/180 (10%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFN----ETLRIERIARTQGG 104
T++ G + L VTG P P++ WTK A + + ++ N T+ I R+ G
Sbjct: 13701 TVKAGTKIELPATVTGKPEPKITWTK-ADMILKQDKRITIENVPKKSTVTIVDSKRSDTG 13759
Query: 105 RYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPP 164
Y +A N G + V+V LD+P ++DV C + NPP
Sbjct: 13760 TYIIEAVNVCG---RATAVVEVNVLDKPGPPAAFDITDVTNE---------SCLLTWNPP 13807
Query: 165 ARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGI 224
+ ++ + + +++ L + + K L P Y +V+ N+ G+
Sbjct: 13808 RDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPN--KEYIFRVAAENMYGV 13865
Score = 36.6 bits (83), Expect = 0.11
Identities = 30/95 (31%), Positives = 44/95 (46%), Gaps = 3/95 (3%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSA-SDKFQETSVFNET-LRIERIARTQGGRYY 107
I G TL + +VTG P P WTK G D+ +V ++ L I+ R GRY
Sbjct: 15116 IMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYV 15175
Query: 108 CKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSD 142
A N G + RV+V + P+L + V++
Sbjct: 15176 ITATNSCG-SKFAAARVEVFDVPGPVLDLKPVVTN 15209
Score = 36.6 bits (83), Expect = 0.11
Identities = 58/258 (22%), Positives = 100/258 (38%), Gaps = 38/258 (14%)
Query: 505 SRDMSGTYRCQTARYNGFNV-RPREAQVQLNVQFPPEV-EPSSQDVRQALGRPVLLRC-- 560
S D + Y + N + RP E + + P E+ EP D+ ++ + V++R
Sbjct: 18566 SLDENQEYEFRVCAQNQVGIGRPAELKEAIK---PKEILEPPEIDLDASMRKLVIVRAGC 18622
Query: 561 -----SLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDH-AELRLDAVTRDSSGSYE 614
+++RG P WR G V + D A L + TRD SG Y
Sbjct: 18623 PIRLFAIVRGRPA--PKVTWRKVGI---DNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYS 18677
Query: 615 CSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLS--KNYSYVLQWTQREPDAVDP 672
++ N G A V DTP P K+S S + W E D
Sbjct: 18678 LTLVNPAGEKAVFVNVRV--------LDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQ 18729
Query: 673 VLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAG-- 730
V +Y + R+ ++ V++ + +T+L + Y R+T +G G
Sbjct: 18730 VTHYIVEKREADRKTWSTVTPEVKKT------SFHVTNLVPGNEYYFRVTAVNEYGPGVP 18783
Query: 731 -DMASRIIHYTEPINSPN 747
D+ ++ ++P++ P+
Sbjct: 18784 TDVPKPVL-ASDPLSEPD 18800
Score = 36.2 bits (82), Expect = 0.15
Identities = 19/70 (27%), Positives = 29/70 (41%), Gaps = 3/70 (4%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE---TLRIERIARTQGGR 105
T+ EG+++ L+C ++G+P P V W + F L I GR
Sbjct: 953 TVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGR 1012
Query: 106 YYCKAENGVG 115
+ C A N G
Sbjct: 1013 FTCSAVNEAG 1022
Score = 36.2 bits (82), Expect = 0.15
Identities = 31/116 (26%), Positives = 50/116 (43%), Gaps = 10/116 (8%)
Query: 210 ASYTCQVSVRNVCGI--PDKAITFRLTNTTAPPALKL--SVNETLVVNPGENVTVQCLLT 265
A Y +VS N G P + + PPA++L SV + + G+ + + ++T
Sbjct: 15070 ADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVT 15129
Query: 266 GGDPLPQLQWSHGPGPLP-----LGALAQGGTLSIPSVQARDSGYYNCTATNNVGN 316
G P+P W+ G L + + L I +D G Y TATN+ G+
Sbjct: 15130 GR-PVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGS 15184
Score = 35.8 bits (81), Expect = 0.20
Identities = 85/406 (20%), Positives = 138/406 (33%), Gaps = 73/406 (17%)
Query: 149 QEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQD 208
++ V L+C + S A W + + S+ N V + G+ ++L LK D
Sbjct: 12031 EKDEVILQCEI-SKADAPVKWFKDGKEIKPSK-NAV-----IKADGKKRMLILKKALKSD 12083
Query: 209 YASYTCQVSVRNVCG---IPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLT 265
YTC G I D+ I P + V ET E + ++
Sbjct: 12084 IGQYTCDCGTDKTSGKLDIEDREIKL------VRPLHSVEVMET------ETARFETEIS 12131
Query: 266 GGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLL 325
D H L AL Q P + ++ G + +N V+
Sbjct: 12132 EDD-------IHANWKLKGEALLQ-----TPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQ 12179
Query: 326 VRSMKN-ATFQITPDVIK-----ESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPAR 379
++K+ A ++ P VI + + G+ C + E + +W+ GK
Sbjct: 12180 AANVKSSAHLRVKPRVIGLLRPLKDVTVTAGETATFDCELS---YEDIPVEWYLKGKKLE 12236
Query: 380 MSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVP 439
S +++ P +L L D+ D G A D N+ +
Sbjct: 12237 PSDKVV-----PRSEGKVHTLTLRDVKLEDAGEVQLTAK-------DFKTHANLFVKE-- 12282
Query: 440 PTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKL 499
P + K TV EG+ A L+CEV + V W K + E DG++
Sbjct: 12283 PPVEFTKPLEDQTVEEGATAVLECEV-SRENAKVKWF---KNGTEILKSKKYEIVADGRV 12338
Query: 500 R---LERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVE 542
R + + + TY C + + LNV PP VE
Sbjct: 12339 RKLVIHDCTPEDIKTYTCDAKDF--------KTSCNLNV-VPPHVE 12375
Score = 35.8 bits (81), Expect = 0.20
Identities = 25/87 (28%), Positives = 37/87 (42%), Gaps = 8/87 (9%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQ----ETSVFNETLRIERIARTQGGR 105
++ G T+ ++ G P P +WT T GS + ET F+ L I+ R G
Sbjct: 17522 VKAGTTVRFPAIIRGVPVPTAKWT-TDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGE 17580
Query: 106 YYCKAENGVGVPAIKSIRVDVQYLDEP 132
Y N G K++ V + LD P
Sbjct: 17581 YQITVSNAAG---SKTVAVHLTVLDVP 17604
Score = 35.4 bits (80), Expect = 0.26
Identities = 38/137 (27%), Positives = 57/137 (41%), Gaps = 12/137 (8%)
Query: 306 YNCTATNNVG--NPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVP 363
+ A N G +PA +LV+ I + ++I++G L+LS + VP
Sbjct: 17187 FRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVP 17246
Query: 364 QEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAP 423
KVT W K + A R+ VT V S LE+ + D G Y P A
Sbjct: 17247 FPKVT--WKKEDRDAPTKARIDVT-------PVGSKLEIRNAAHEDGGIYSLTVENP-AG 17296
Query: 424 VPDLSVEVNISSETVPP 440
+SV+V + + PP
Sbjct: 17297 SKTVSVKVLVLDKPGPP 17313
Score = 35.4 bits (80), Expect = 0.26
Identities = 26/91 (28%), Positives = 38/91 (41%), Gaps = 7/91 (7%)
Query: 242 LKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGA------LAQGGTLSI 295
L +++ +++ GE+V V G P P + W L A L+I
Sbjct: 27273 LDVALRTSVIAKAGEDVQVLIPFKGRPP-PTVTWRKDEKNLGSDARYSIENTDSSSLLTI 27331
Query: 296 PSVQARDSGYYNCTATNNVGNPAKKTVNLLV 326
P V D+G Y T N VG P TV++ V
Sbjct: 27332 PQVTRNDTGKYILTIENGVGEPKSSTVSVKV 27362
Score = 35.0 bits (79), Expect = 0.33
Identities = 77/338 (22%), Positives = 125/338 (36%), Gaps = 55/338 (16%)
Query: 433 ISSETVPPTISVP-KGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPL 491
+ + PP + + K R V+ V+ G ++ ++ G+P P + W++ G+ +
Sbjct: 25780 VKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAK---------DGIEI 25830
Query: 492 EETPDGKLRLERVSRD------MSGTYRCQTARY--NGFNVR-PREAQVQLNVQFPPEVE 542
EE + R E +S D + R T +Y NV R V V P
Sbjct: 25831 EE----RARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPP 25886
Query: 543 PSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRL 602
++ +CSL G PQ A + + A EL++
Sbjct: 25887 AGPLEINGLTAE----KCSLSWGRPQEDGGADIDY---YIVEKRETSHLAWTICEGELQM 25939
Query: 603 DA--VTRDSSGS---YECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSK--N 655
+ VT+ G+ + + N G L V+ KA P F P+P S +++
Sbjct: 25940 TSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDP---FTVPSPPTSLEITSVTK 25996
Query: 656 YSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQL--LEYILTDLRV 713
S L W++ E D + Y + R+ N V RV K + L T LR
Sbjct: 25997 ESMTLCWSRPESDGGSEISGYIIERREKNSLRWV-------RVNKKPVYDLRVKSTGLRE 26049
Query: 714 PHSYEVRLTPYTTFGAG----DMASRIIHYTEPINSPN 747
YE R+ Y AG S +I +P+ P+
Sbjct: 26050 GCEYEYRV--YAENAAGLSLPSETSPLIRAEDPVFLPS 26085
Score = 35.0 bits (79), Expect = 0.33
Identities = 26/104 (25%), Positives = 45/104 (43%), Gaps = 4/104 (3%)
Query: 41 DNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDK-FQETSVFNETLRIERIA 99
D+ + ++ G + + G P P V W+K + + +T+ +L IE
Sbjct: 26189 DSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENAN 26248
Query: 100 RTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDV 143
R G+Y +N V + S+ + V+ LD P + TV DV
Sbjct: 26249 RNDSGKYTLTIQN---VLSAASLTLVVKVLDTPGPPTNITVQDV 26289
Score = 35.0 bits (79), Expect = 0.33
Identities = 37/185 (20%), Positives = 74/185 (40%), Gaps = 16/185 (8%)
Query: 43 ISERVYTIREGDTLMLQCLVTGHPRPQVRW--TKTAGSASDKFQETSVFNE-TLRIERIA 99
I+ ++ T + G + ++G P P+V W + +D+ T+ + TL ++
Sbjct: 28652 ITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSM 28711
Query: 100 RTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTV 159
R GRY+ EN GV K+ V V + P V G C +
Sbjct: 28712 RGDSGRYFLTLENTAGV---KTFSVTVVVIGRP--------GPVTGPIEVSSVSAESCVL 28760
Query: 160 NSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVR 219
+ P ++ + +++G ++ + + + +K+ +L Y Y+ +VS
Sbjct: 28761 SWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHL--TKYMEYSFRVSSE 28818
Query: 220 NVCGI 224
N G+
Sbjct: 28819 NRFGV 28823
Score = 34.7 bits (78), Expect = 0.44
Identities = 19/77 (24%), Positives = 33/77 (42%), Gaps = 6/77 (7%)
Query: 245 SVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQ------GGTLSIPSV 298
++ + L + G+ + + + G PLP+ WS + + Q L+I
Sbjct: 20383 TIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYA 20442
Query: 299 QARDSGYYNCTATNNVG 315
+D+G Y TATN G
Sbjct: 20443 TRKDAGEYTITATNPFG 20459
Score = 34.7 bits (78), Expect = 0.44
Identities = 35/129 (27%), Positives = 55/129 (42%), Gaps = 9/129 (6%)
Query: 20 GVYAPA---QAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTA 76
GV PA +IV A + D R +R G ++ + + G P P+V WTK
Sbjct: 20755 GVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDN 20814
Query: 77 GSASDK--FQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPML 134
+ ++ + T F L I R G++ EN G KS V+V+ LD P
Sbjct: 20815 INLKNRANIENTESFT-LLIIPECNRYDTGKFVMTIENPAGK---KSGFVNVRVLDTPGP 20870
Query: 135 TVHQTVSDV 143
++ +D+
Sbjct: 20871 VLNLRPTDI 20879
Score = 34.7 bits (78), Expect = 0.44
Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDK--FQETSVFNET-LRIERIARTQGGRY 106
I+ G++L ++ LV G P P+V W K + + T V T L + R G Y
Sbjct: 27970 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVY 28029
Query: 107 YCKAENGVGVPAIKSIRVDVQ 127
+A+N G A I+V VQ
Sbjct: 28030 TVEAKNASG-SAKAEIKVKVQ 28049
Score = 34.3 bits (77), Expect = 0.57
Identities = 38/152 (25%), Positives = 63/152 (41%), Gaps = 17/152 (11%)
Query: 331 NATFQITPDVIKES-ENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRN 389
+AT +TP +I ++I + ++ V V E ++Y+W KNG + + + +
Sbjct: 2961 SATLTVTPIMITSMLKDINAEEKDTITFEV-TVNYEGISYKWLKNGVEIKSTDKCQM--- 3016
Query: 390 DPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRA 449
+T SL + ++HF D Y +A L VE I K
Sbjct: 3017 --RTKKLTHSLNIRNVHFGDAADYTFVAG-KATSTATLYVEAR--------HIEFRKHIK 3065
Query: 450 VVTVREGSPAELQCEVRGKPRPPVLWSRVDKE 481
+ V E A +CEV +P V W + D+E
Sbjct: 3066 DIKVLEKKRAMFECEV-SEPDITVQWMKDDQE 3096
Score = 34.3 bits (77), Expect = 0.57
Identities = 25/107 (23%), Positives = 48/107 (44%), Gaps = 2/107 (1%)
Query: 408 SDYGTYLCMASFPGAPVPDLSVEVNISSETV-PPTISVPKG-RAVVTVREGSPAELQCEV 465
++Y + A+ G P E I+ + + PP + + R V+TVR G + V
Sbjct: 17873 NEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARV 17932
Query: 466 RGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTY 512
+G+P P + W++ K +++ P +L+++ R G Y
Sbjct: 17933 KGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKY 17979
Score = 34.3 bits (77), Expect = 0.57
Identities = 26/102 (25%), Positives = 44/102 (43%), Gaps = 6/102 (5%)
Query: 20 GVYAPAQAQIVHAGQACVVKE---DNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTA 76
G AP +++ V + ++ E I +++ + GD + ++ V G P+P V W K
Sbjct: 21044 GRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGD 21103
Query: 77 GSASDKFQ---ETSVFNETLRIERIARTQGGRYYCKAENGVG 115
+ ET+ + L I R+ G Y A N VG
Sbjct: 21104 QILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVG 21145
Score = 34.3 bits (77), Expect = 0.57
Identities = 19/71 (26%), Positives = 31/71 (43%), Gaps = 3/71 (4%)
Query: 48 YTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQ---ETSVFNETLRIERIARTQGG 104
Y+I+ G+ L ++ V G PRP + W K + E + + L I+ + G
Sbjct: 24321 YSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFG 24380
Query: 105 RYYCKAENGVG 115
+Y A N G
Sbjct: 24381 KYTVTATNSAG 24391
Score = 34.3 bits (77), Expect = 0.57
Identities = 26/74 (35%), Positives = 33/74 (44%), Gaps = 15/74 (20%)
Query: 427 LSVEVNISSETVPPTISVPK------GRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDK 480
LS V I TV I P+ A VTVR G L+ +GKP+P + W
Sbjct: 27543 LSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISW----- 27597
Query: 481 EAALLPSGLPLEET 494
L GLPL+E+
Sbjct: 27598 ----LKDGLPLKES 27607
Score = 34.3 bits (77), Expect = 0.57
Identities = 21/73 (28%), Positives = 30/73 (41%), Gaps = 3/73 (4%)
Query: 46 RVYTIREGDTLMLQCLVTGHPRPQVRWTKTAG--SASDKFQETSV-FNETLRIERIARTQ 102
R T+ EG++ C G P P V W + S S + Q T+ + T I + +
Sbjct: 32568 RSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASD 32627
Query: 103 GGRYYCKAENGVG 115
G Y EN G
Sbjct: 32628 EGNYSVVVENSEG 32640
Score = 33.9 bits (76), Expect = 0.75
Identities = 47/190 (24%), Positives = 71/190 (37%), Gaps = 9/190 (4%)
Query: 437 TVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDK--EAALLPSGLPLEET 494
T PT + P VV EGS A + + G P P V W R + + LP
Sbjct: 3 TQAPTFTQPLQSVVVL--EGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSD 60
Query: 495 PDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGR 554
KL + V++ SG Y + +G E V+ PP Q + G
Sbjct: 61 GRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETA-PPNFVQRLQSMTVRQGS 119
Query: 555 PVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYE 614
V L+ + G P + + G + + E ++ L +A D SG+Y
Sbjct: 120 QVRLQVR-VTGIPTPVVK--FYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPED-SGTYS 175
Query: 615 CSVSNDVGSA 624
+ +N VG A
Sbjct: 176 VNATNSVGRA 185
Score = 33.9 bits (76), Expect = 0.75
Identities = 70/343 (20%), Positives = 125/343 (36%), Gaps = 76/343 (22%)
Query: 163 PPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVC 222
P + W +G++ L S + I G+ L++KN + +D +Y R VC
Sbjct: 8684 PEIKLSWYKGTEKLEPSDKFEISI------DGDRHTLRVKNCQLKDQGNY------RLVC 8731
Query: 223 GIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPL 282
G + T PA + + + + + G+ T+ C + P + +W L
Sbjct: 8732 GPHIASAKL----TVIEPAWERHLQD-VTLKEGQTCTMTCQFSV--PNVKSEWFRNGRIL 8784
Query: 283 -PLGALA-----QGGTLSIPSVQARDSGYYNCTATNNVGNP-----------AKKTVNLL 325
P G + L+I V+A D G Y C + + K+ N++
Sbjct: 8785 KPQGRHKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETSAELRIEAEPIQFTKRIQNIV 8844
Query: 326 VRSMKNATFQIT-------------PDVIKESENIQLGQDLKLSCHV----DAVPQEKVT 368
V ++ATF+ P + ES+ D + CH + P ++
Sbjct: 8845 VSEHQSATFECEVSFDDAIVTWYKGPTELTESQKYNFRNDGR--CHYMTIHNVTPDDEGV 8902
Query: 369 YQWFKNGKP---ARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVP 425
Y +P AR + L +T + +L L+ D+ S P+P
Sbjct: 8903 YSVIARLEPRGEARSTAELYLTTKEIKL-----ELKPPDIPDS------------RVPIP 8945
Query: 426 DLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGK 468
+ + + E +PP ++ P + T E P + EV K
Sbjct: 8946 TMPIRA-VPPEEIPPVVAPPIPLLLPTPEEKKPPPKRIEVTKK 8987
Score = 33.9 bits (76), Expect = 0.75
Identities = 25/106 (23%), Positives = 49/106 (46%), Gaps = 6/106 (5%)
Query: 436 ETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETP 495
+ +PP I +P+ +T++ G ++ V GKP P W + + E + S L + +
Sbjct: 18896 QLLPPKILMPEQ---ITIKAGKKLRIEAHVYGKPHPTCKWKKGEDE-VVTSSHLAVHKAD 18951
Query: 496 DGK-LRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE 540
L ++ V+R SG Y +G + + + V ++ PP+
Sbjct: 18952 SSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKV-VVMDAPGPPQ 18996
Score = 33.9 bits (76), Expect = 0.75
Identities = 29/117 (24%), Positives = 49/117 (41%), Gaps = 6/117 (5%)
Query: 408 SDYGTYLCMASFPGAPVPDLSVEVNISSETV-PPTISVPKG-RAVVTVREGSPAELQCEV 465
++Y +C + G P ++ E + PP I + R VV +R + L +
Sbjct: 25072 TEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTI 25131
Query: 466 RGKPRPPVLWSRVDKEAALLPSGLPLEETPD-GKLRLERVSRDMSGTYRCQTARYNG 521
+G+P P V W +K +L +E T L ++ V+R SG Y +G
Sbjct: 25132 KGRPEPEVKW---EKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSG 25185
Score = 33.9 bits (76), Expect = 0.75
Identities = 19/89 (21%), Positives = 39/89 (43%), Gaps = 6/89 (6%)
Query: 47 VYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNET---LRIERIARTQG 103
V ++ G+ L + + G P P + W K ++ + + + L ++ R
Sbjct: 25798 VIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDT 25857
Query: 104 GRYYCKAENGVGVPAIKSIRVDVQYLDEP 132
G+Y +N G +S+ V+ + LD+P
Sbjct: 25858 GQYVLTLKNVAGT---RSVAVNCKVLDKP 25883
Score = 33.9 bits (76), Expect = 0.75
Identities = 43/196 (21%), Positives = 75/196 (38%), Gaps = 16/196 (8%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTKTAGS--ASDKFQETS-VFNETLRIERIARTQGGR 105
T + G+ L C + G P P ++W + S K++ +S TL + + G
Sbjct: 30543 TTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGV 30602
Query: 106 YYCKAENGVG-VPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPP 164
Y C A N VG V + + P + + G+ T+ L P
Sbjct: 30603 YTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGS-----TLRLHVMYIGRPV 30657
Query: 165 ARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGI 224
W G L +S++ ++ E YT L +KN++ + +A +V + NV G
Sbjct: 30658 PAMTWFHGQKLLQNSENITIENTEH-YTH-----LVMKNVQRKTHAG-KYKVQLSNVFGT 30710
Query: 225 PDKAITFRLTNTTAPP 240
D + + + P
Sbjct: 30711 VDAILDVEIQDKPDKP 30726
Score = 33.5 bits (75), Expect = 0.97
Identities = 25/83 (30%), Positives = 36/83 (43%), Gaps = 8/83 (9%)
Query: 239 PPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGP----GPLPLGALAQGGT-- 292
PP L + V+ GE+VT++C ++G P P + W + Q G
Sbjct: 942 PPTLVSGLKNVTVIE-GESVTLECHISGY-PSPTVTWYREDYQIESSIDFQITFQSGIAR 999
Query: 293 LSIPSVQARDSGYYNCTATNNVG 315
L I A DSG + C+A N G
Sbjct: 1000 LMIREAFAEDSGRFTCSAVNEAG 1022
Score = 33.5 bits (75), Expect = 0.97
Identities = 26/87 (29%), Positives = 38/87 (43%), Gaps = 6/87 (6%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWTK--TAGSASDKFQETSVFNE-TLRIERIARTQGGR 105
T++ G + L V G P P V W K T ++ + N TL + + R G
Sbjct: 19306 TVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGD 19365
Query: 106 YYCKAENGVGVPAIKSIRVDVQYLDEP 132
Y AEN G KS + ++ LD+P
Sbjct: 19366 YTITAENSSG---SKSATIKLKVLDKP 19389
Score = 33.5 bits (75), Expect = 0.97
Identities = 22/71 (30%), Positives = 31/71 (43%), Gaps = 17/71 (23%)
Query: 411 GTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPR 470
G C+ S+ G PV DL +E VV R G+ +L+ + GKP
Sbjct: 26859 GPITCIDSY-GGPVIDLPLEYT----------------EVVKYRAGTSVKLRAGISGKPA 26901
Query: 471 PPVLWSRVDKE 481
P + W + DKE
Sbjct: 26902 PTIEWYKDDKE 26912
Score = 33.5 bits (75), Expect = 0.97
Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 8/98 (8%)
Query: 448 RAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRL-ERVSR 506
+ VT+R G+ L V G+P P + WS K+ L S ++ T L + ++V+R
Sbjct: 29453 KKTVTIRAGASLRLMVSVSGRPPPVITWS---KQGIDLASRAIIDTTESYSLLIVDKVNR 29509
Query: 507 DMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPS 544
+G Y + +G + A V + V P PS
Sbjct: 29510 YDAGKYTIEAENQSG----KKSATVLVKVYDTPGPCPS 29543
Score = 33.1 bits (74), Expect = 1.3
Identities = 21/74 (28%), Positives = 29/74 (39%), Gaps = 11/74 (14%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRW--------TKTAGSASDKFQETSVFNETLRIERIART 101
+ EG T + ++G P P+V W T T F + L I + +
Sbjct: 17 VLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDG---RAKLTIPAVTKA 73
Query: 102 QGGRYYCKAENGVG 115
GRY KA NG G
Sbjct: 74 NSGRYSLKATNGSG 87
Score = 33.1 bits (74), Expect = 1.3
Identities = 19/65 (29%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Query: 448 RAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRD 507
R ++ +R G L ++G+P P V W +VD E + + + + L L+ V+R
Sbjct: 22949 RKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGE--IRDAAIIDVTSSFTSLVLDNVNRY 23006
Query: 508 MSGTY 512
SG Y
Sbjct: 23007 DSGKY 23011
Score = 33.1 bits (74), Expect = 1.3
Identities = 41/177 (23%), Positives = 65/177 (36%), Gaps = 29/177 (16%)
Query: 151 KTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKL--KNLRPQD 208
+ V L + PP W L S+ V+ + TKV KL + +D
Sbjct: 29754 RPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETH--------TKVAKLTIRETTIRD 29805
Query: 209 YASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNE------TLVVNPGENVTVQC 262
YT ++ +NV G + I + + PP + ++E T+ P E
Sbjct: 29806 TGEYTLEL--KNVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPE------ 29857
Query: 263 LLTGGDPLP----QLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVG 315
L GG PL + + +H PG LP+ T + + + ATN G
Sbjct: 29858 -LDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFG 29913
Score = 33.1 bits (74), Expect = 1.3
Identities = 41/189 (21%), Positives = 67/189 (35%), Gaps = 25/189 (13%)
Query: 292 TLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQ 351
TL I DSG Y TN G + AT +T + + +
Sbjct: 32430 TLEILDCHTDDSGTYRAVCTNYKGEASDY-----------ATLDVTGGDYTTYASQRRDE 32478
Query: 352 DLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYG 411
++ S + E FK K + M V ++ SL +
Sbjct: 32479 EVPRSVFPELTRTEAYAVSSFK--KTSEMEASSSVREVKSQMTETRESLSSYE------- 32529
Query: 412 TYLCMASFPGAPVPDLSVEVNISSETVPPTIS---VPKGRAVVTVREGSPAELQCEVRGK 468
+ A A + + S+E ++ + T++ + K R++ TV EG A C+ G+
Sbjct: 32530 -HSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSM-TVYEGESARFSCDTDGE 32587
Query: 469 PRPPVLWSR 477
P P V W R
Sbjct: 32588 PVPTVTWLR 32596
Score = 32.7 bits (73), Expect = 1.7
Identities = 11/23 (47%), Positives = 17/23 (73%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRW 72
+ EG+T +C VTG+P+P+V W
Sbjct: 1852 VLEGETARFRCRVTGYPQPKVNW 1874
Score = 32.7 bits (73), Expect = 1.7
Identities = 46/221 (20%), Positives = 76/221 (34%), Gaps = 36/221 (16%)
Query: 45 ERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDK----FQETSVFNETLRIERIAR 100
E T+ +G L L C + + V W K +K L I
Sbjct: 11219 EEEVTVVKGQPLYLSCEL--NKERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADD 11276
Query: 101 TQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEK-TVFLRCTV 159
T G Y EN + ++V V+ + + + V +R + K T C +
Sbjct: 11277 TDAGTYTVTVENANNLECSSCVKV-VEVIRDWL------VKPIRDQHVKPKGTAIFACDI 11329
Query: 160 NSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVR 219
+ P W +G D + ++ +I G LK+KN P+D A Y ++ +
Sbjct: 11330 AKDTP-NIKWFKGYDEIPAEPNDKTEILR----DGNHLYLKIKNAMPEDIAEYAVEIEGK 11384
Query: 220 NVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTV 260
P L L E ++ P E+VT+
Sbjct: 11385 RY-----------------PAKLTLGEREVELLKPIEDVTI 11408
Score = 32.7 bits (73), Expect = 1.7
Identities = 37/140 (26%), Positives = 51/140 (36%), Gaps = 18/140 (12%)
Query: 596 DH--AELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLS 653
DH A L + R +G Y ++ N +GSA V P P + K S
Sbjct: 14438 DHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV--------IGLPGPCKDIKAS 14489
Query: 654 --KNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDL 711
S L W E D P+L+Y L R+ + IPV E L + + DL
Sbjct: 14490 DITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRT----YIPVMSGE--NKLSWTVKDL 14543
Query: 712 RVPHSYEVRLTPYTTFGAGD 731
Y R+ G G+
Sbjct: 14544 IPNGEYFFRVKAVNKVGGGE 14563
Score = 32.7 bits (73), Expect = 1.7
Identities = 31/114 (27%), Positives = 45/114 (39%), Gaps = 10/114 (8%)
Query: 212 YTCQVSVRNVCGIPDKAI---TFRLTNTTAPPALKLSVN--ETLVVNPGENVTVQCLLTG 266
Y +VS N G D T + + P L + N +T VV G ++ + +
Sbjct: 28324 YKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRL-FIAYQ 28382
Query: 267 GDPLPQLQWSHGPGPLPLGA----LAQGGTLSIPSVQARDSGYYNCTATNNVGN 316
G P P WS L L A TL++ + D+G Y T NN G+
Sbjct: 28383 GRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNSGS 28436
Score = 32.3 bits (72), Expect = 2.2
Identities = 17/61 (27%), Positives = 30/61 (49%), Gaps = 4/61 (6%)
Query: 453 VREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDG-KLRLERVSRDMSGT 511
++ G L ++G P P V W + D++A P+ ++ TP G KL + + + G
Sbjct: 17230 IKVGDTLRLSAIIKGVPFPKVTWKKEDRDA---PTKARIDVTPVGSKLEIRNAAHEDGGI 17286
Query: 512 Y 512
Y
Sbjct: 17287 Y 17287
Score = 32.3 bits (72), Expect = 2.2
Identities = 23/84 (27%), Positives = 36/84 (42%), Gaps = 4/84 (4%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQ-ETSVFNETLRIERIARTQGGRYYC 108
+R+G + L + G P P +WTK S + TS + L I+ R G Y
Sbjct: 30148 VRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDL 30207
Query: 109 KAENGVGVPAIKSIRVDVQYLDEP 132
EN G K++ + V+ + P
Sbjct: 30208 VLENKCGK---KAVYIKVRVIGSP 30228
Score = 32.0 bits (71), Expect = 2.8
Identities = 63/305 (20%), Positives = 104/305 (34%), Gaps = 57/305 (18%)
Query: 47 VYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNET-----LRIERIART 101
V + EG +++ C V G+P+P V W K+ + ++ +N+ L I
Sbjct: 1090 VQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFAD 1149
Query: 102 QGGRYYCKAENGVG-VPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVN 160
G Y N G A S+ + Y E ++ Q + + + T F++
Sbjct: 1150 DAGEYTIVVRNKHGETSASASLLEEADY--ELLMKSQQEML-----YQTQVTAFVQEPKV 1202
Query: 161 SNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRN 220
F++ Q L + K + +D + R
Sbjct: 1203 GETAPGFVYSEYEKEYEKEQ--------ALIRKKMAKDTVVVRTYVEDQEFHISSFEERL 1254
Query: 221 VCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGEN---------------------VT 259
+ K I +R+ TT L+ E + V+ E+ VT
Sbjct: 1255 I-----KEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKNYRILEGMGVT 1309
Query: 260 VQCLLTGGDPLPQLQW-------SHGPGPLPLGALAQG-GTLSIPSVQARDSGYYNCTAT 311
C ++G PLP++ W HG + L G +L IP V D G Y A+
Sbjct: 1310 FHCKMSGY-PLPKIAWYKDGKRIKHGER-YQMDFLQDGRASLRIPVVLPEDEGIYTAFAS 1367
Query: 312 NNVGN 316
N GN
Sbjct: 1368 NIKGN 1372
Score = 32.0 bits (71), Expect = 2.8
Identities = 64/351 (18%), Positives = 117/351 (33%), Gaps = 64/351 (18%)
Query: 190 LYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGI-----PDKAITFRLTNTTAPPALKL 244
+ ++G ++L + D A Y+C+V G+ + T L N
Sbjct: 12421 IISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLAN--------- 12471
Query: 245 SVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHG------PGPLPLGALAQGGTLSIPSV 298
+ E T++ + P ++ W G G + + L I +
Sbjct: 12472 -------IEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNA 12524
Query: 299 QARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQL--GQDLKLS 356
D+G YNC P+ +T K ++ + I + +N+++ G+ +
Sbjct: 12525 HLEDAGNYNCRL------PSSRT------DGKVKVHELAAEFISKPQNLEILEGEKAEFV 12572
Query: 357 CHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCM 416
C ++ +E QW ++ K + V + + V D D GTY+ M
Sbjct: 12573 C---SISKESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVK-----DATLQDMGTYVVM 12624
Query: 417 ASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWS 476
A + TV + + V+E CEV + W
Sbjct: 12625 VGAARA----------AAHLTVIEKLRIVVPLKDTRVKEQQEVVFNCEVNTE-GAKAKWF 12673
Query: 477 RVDKEAALLPSG--LPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVR 525
R E A+ S + L++ LR+ D Y + G NV+
Sbjct: 12674 R--NEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVK 12722
Score = 32.0 bits (71), Expect = 2.8
Identities = 31/135 (22%), Positives = 52/135 (38%), Gaps = 14/135 (10%)
Query: 599 ELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLS--KNY 656
EL + R+ G+Y + SN +GS V +D P+P R+ ++ K
Sbjct: 15461 ELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEV--------YDRPSPPRNLAVTDIKAE 15512
Query: 657 SYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHS 716
S L W + + +Y + R ++ A + + VEK Y + L
Sbjct: 15513 SCYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEK----RYGIWKLIPNGQ 15568
Query: 717 YEVRLTPYTTFGAGD 731
YE R+ +G D
Sbjct: 15569 YEFRVRAVNKYGISD 15583
Score = 31.6 bits (70), Expect = 3.7
Identities = 26/104 (25%), Positives = 45/104 (43%), Gaps = 12/104 (11%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTK---TAGSASDKFQET------SVFNETLRIERIAR 100
++ G+ + + VTG P P++ W+K +D Q T S L I + R
Sbjct: 15410 VKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVR 15469
Query: 101 TQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVR 144
G Y A N +G +++ V+V D P + V+D++
Sbjct: 15470 EDKGTYTVTASNRLG-SVFRNVHVEV--YDRPSPPRNLAVTDIK 15510
Score = 31.6 bits (70), Expect = 3.7
Identities = 31/135 (22%), Positives = 48/135 (35%), Gaps = 19/135 (14%)
Query: 600 LRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPT----RSHKLSKN 655
L ++ R SG Y + N VG + + D P P + ++S +
Sbjct: 21123 LNINECVRSDSGPYPLTARNIVGEVGDVITIQVH--------DIPGPPTGPIKFDEVSSD 21174
Query: 656 YSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPH 715
+ W E D P+ NY + +RQ + V A V R Y T L
Sbjct: 21175 F-VTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRT------TYKATRLTTGL 21227
Query: 716 SYEVRLTPYTTFGAG 730
Y+ R+ +G G
Sbjct: 21228 EYQFRVKAQNRYGVG 21242
Score = 31.6 bits (70), Expect = 3.7
Identities = 22/87 (25%), Positives = 42/87 (48%), Gaps = 4/87 (4%)
Query: 427 LSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLP 486
L V V T+ P++ +P +++ G +++ V G+PRP + W + D E
Sbjct: 24299 LGVPVIAKDLTIQPSLKLPFN--TYSIQAGEDLKIEIPVIGRPRPNISWVK-DGEPLKQT 24355
Query: 487 SGLPLEETPDGK-LRLERVSRDMSGTY 512
+ + +EET L ++ ++D G Y
Sbjct: 24356 TRVNVEETATSTVLHIKEGNKDDFGKY 24382
Score = 31.6 bits (70), Expect = 3.7
Identities = 32/132 (24%), Positives = 54/132 (40%), Gaps = 21/132 (15%)
Query: 211 SYTCQVSVRNVCGIPDKA------ITFRLTNTTAPPALKLSVN---ETLVVNPGENVTVQ 261
+Y +V +N G+ K +T R + APP +L + + + G ++ +
Sbjct: 29011 TYEFRVLAKNAAGVISKGSESTGPVTCR--DEYAPPKAELDARLHGDLVTIRAGSDLVLD 29068
Query: 262 CLLTGGDPLPQLQWSHGPGPL------PLGALAQGGTLSIPSVQARDSGYYNCTATNNVG 315
+ GG P P++ W+ G L L + T I DSG Y T N G
Sbjct: 29069 AAV-GGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASG 29127
Query: 316 NPAKKTVNLLVR 327
K V+++V+
Sbjct: 29128 T---KAVSVMVK 29136
Score = 31.2 bits (69), Expect = 4.8
Identities = 41/162 (25%), Positives = 65/162 (40%), Gaps = 21/162 (12%)
Query: 335 QITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELP 394
+I ++ ESE + G C V P +T W K+G R S + + +
Sbjct: 11120 EIKDIILTESEFV--GSSAIFECLVS--PSTAIT-TWMKDGSNIRESPKHRFIADGKD-- 11172
Query: 395 AVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVR 454
L +ID+ SD G Y C+ + + + E +P V VTV
Sbjct: 11173 ---RKLHIIDVQLSDAGEYTCVLRLGN---KEKTSTAKLVVEELPVRF-VKTLEEEVTVV 11225
Query: 455 EGSPAELQCEVRGKPRPPVLWSR-----VDKEAALLPSGLPL 491
+G P L CE+ K R V+W + V+K ++P + L
Sbjct: 11226 KGQPLYLSCEL-NKER-DVVWRKDGKIVVEKPGRIVPGVIGL 11265
Score = 31.2 bits (69), Expect = 4.8
Identities = 59/304 (19%), Positives = 110/304 (36%), Gaps = 59/304 (19%)
Query: 448 RAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPD-GKLRLERVSR 506
R + VR G A + +G+P P + WSR + E + +E+ + +L ++ R
Sbjct: 24031 RKGIVVRAGGSARIHIPFKGRPTPEITWSREEGE---FTDKVQIEKGVNYTQLSIDNCDR 24087
Query: 507 DMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGS 566
+ +G Y + +G + A V + V P G
Sbjct: 24088 NDAGKYILKLENSSG----SKSAFVTVKVLDTP-------------------------GP 24118
Query: 567 PQRIA-SAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRD-SSGSYECS-----VSN 619
PQ +A V + L+ PP++ A+ ++ + ++ + ++ S +CS V N
Sbjct: 24119 PQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVEN 24178
Query: 620 DVGSAACLFQVSA----------KAYSPEFYFDTPNPTRSHKLS--KNYSYVLQWTQREP 667
A F+V A + + P+P L+ S L W + E
Sbjct: 24179 LTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEH 24238
Query: 668 DAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTF 727
D VL Y + ++ + V + ++ ++T L Y+ R+ Y
Sbjct: 24239 DGGSRVLGYVVEMQPKGTEKWSI-------VAESKVCNAVVTGLSSGQEYQFRVKAYNEK 24291
Query: 728 GAGD 731
G D
Sbjct: 24292 GKSD 24295
Score = 31.2 bits (69), Expect = 4.8
Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 6/67 (8%)
Query: 448 RAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGK--LRLERVS 505
R + V+ G+ + RG+P P VLWS+ D + +T D + L +E +
Sbjct: 26193 RKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRT----RAYVDTTDSRTSLTIENAN 26248
Query: 506 RDMSGTY 512
R+ SG Y
Sbjct: 26249 RNDSGKY 26255
Score = 31.2 bits (69), Expect = 4.8
Identities = 28/94 (29%), Positives = 41/94 (43%), Gaps = 16/94 (17%)
Query: 47 VYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETS----VFNET----LRIERI 98
V R G ++ L+ ++G P P + W K DK +T+ V N T + I+
Sbjct: 26881 VVKYRAGTSVKLRAGISGKPAPTIEWYK-----DDKELQTNALVCVENTTDLASILIKDA 26935
Query: 99 ARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEP 132
R G Y K N +G S + VQ LD+P
Sbjct: 26936 DRLNSGCYELKLRNAMG---SASATIRVQILDKP 26966
Score = 30.8 bits (68), Expect = 6.3
Identities = 25/92 (27%), Positives = 43/92 (46%), Gaps = 5/92 (5%)
Query: 42 NISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQ-ETSVFNETLRIERIAR 100
++ +R+ + G + + V+G P P V W + + ET+ + ++ I+ R
Sbjct: 16529 SVRDRI-VVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQR 16587
Query: 101 TQGGRYYCKAENGVGVPAIKSIRVDVQYLDEP 132
+ G Y A+N G K+I VDV LD P
Sbjct: 16588 SHQGVYSLLAKNEAG-ERKKTIIVDV--LDVP 16616
Score = 30.8 bits (68), Expect = 6.3
Identities = 18/71 (25%), Positives = 29/71 (40%), Gaps = 3/71 (4%)
Query: 48 YTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQ---ETSVFNETLRIERIARTQGG 104
Y +E L+ + G P P V W K + + E+S N TL + ++ G
Sbjct: 19992 YLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAG 20051
Query: 105 RYYCKAENGVG 115
+Y +N G
Sbjct: 20052 KYTITLKNVAG 20062
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 114 bits (285), Expect = 4e-25
Identities = 103/413 (24%), Positives = 175/413 (42%), Gaps = 46/413 (11%)
Query: 108 CKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARF 167
C+ + ++ +I + + P +T +DV TV+ C NP
Sbjct: 222 CEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSG----NTVYFTCRAEGNPKPEI 277
Query: 168 IWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCG-IPD 226
IW R ++ LS D+ +++ + L ++N + D Y C +NV G +
Sbjct: 278 IWLRNNNELSMKTDSRLNLL-------DDGTLMIQNTQETDQGIYQCM--AKNVAGEVKT 328
Query: 227 KAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGP-GPLPLG 285
+ +T R + A P + T V+ GE+VT++C TG P P++ W+ G PLP+
Sbjct: 329 QEVTLRYFGSPARPTFVIQPQNTEVL-VGESVTLECSATGHPP-PRISWTRGDRTPLPVD 386
Query: 286 A---LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIK 342
+ G L I +V DSG Y C+ATNN+ + T ++V+++ F +TP
Sbjct: 387 PRVNITPSGGLYIQNVVQGDSGEYACSATNNI-DSVHATAFIIVQALPQ--FTVTP---- 439
Query: 343 ESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLEL 402
+ + GQ + C P + W K G + +R LV L + T +
Sbjct: 440 QDRVVIEGQTVDFQCEAKGNPPPVIA--WTKGGSQLSVDRRHLV------LSSGTLRISG 491
Query: 403 IDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAEL 461
+ LH D G Y C A + G+ + + + P S+P TV G+ +L
Sbjct: 492 VALH--DQGQYECQAVNIIGS--QKVVAHLTVQPRVTPVFASIPSD---TTVEVGANVQL 544
Query: 462 QCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRC 514
C +G+P P + W +K+ + +P+G L + V +G Y C
Sbjct: 545 PCSSQGEPEPAITW---NKDGVQVTESGKFHISPEGFLTINDVGPADAGRYEC 594
Score = 97.8 bits (242), Expect = 4e-20
Identities = 103/431 (23%), Positives = 168/431 (38%), Gaps = 41/431 (9%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQE--TSVFNETLRIERIARTQGGRYY 107
+ G+T+ C G+P+P++ W + S K + + TL I+ T G Y
Sbjct: 257 VTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQ 316
Query: 108 CKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARF 167
C A+N G +K+ V ++Y P + ++V L C+ +PP R
Sbjct: 317 CMAKNVAG--EVKTQEVTLRYFGSPARPTF-VIQPQNTEVLVGESVTLECSATGHPPPRI 373
Query: 168 IWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDK 227
W RG T +P + L ++N+ D Y C + N+ +
Sbjct: 374 SWTRGDRTPLP--------VDPRVNITPSGGLYIQNVVQGDSGEYACS-ATNNIDSVHAT 424
Query: 228 AITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG-- 285
A A P ++ + +V+ G+ V QC G P P + W+ G L +
Sbjct: 425 AFII----VQALPQFTVTPQDRVVIE-GQTVDFQCEAKGNPP-PVIAWTKGGSQLSVDRR 478
Query: 286 -ALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKES 344
+ GTL I V D G Y C A N +G+ K +L V+ F P
Sbjct: 479 HLVLSSGTLRISGVALHDQGQYECQAVNIIGS-QKVVAHLTVQPRVTPVFASIP----SD 533
Query: 345 ENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELID 404
+++G +++L C P+ +T W K+G S + ++ PE L + D
Sbjct: 534 TTVEVGANVQLPCSSQGEPEPAIT--WNKDGVQVTESGKFHIS---PE-----GFLTIND 583
Query: 405 LHFSDYGTYLCMA--SFPGAPVP-DLSVEVNISSETVPPTISVPKGRAVVTVREGSPAEL 461
+ +D G Y C+A + A V LSV V S P ++ A+ TV +
Sbjct: 584 VGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTR 643
Query: 462 QCEVRGKPRPP 472
+PR P
Sbjct: 644 THLFDSRPRSP 654
Score = 87.0 bits (214), Expect = 7e-17
Identities = 100/430 (23%), Positives = 160/430 (37%), Gaps = 47/430 (10%)
Query: 203 NLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQC 262
N + Y ++ R+V I + + T+ P + V G V C
Sbjct: 215 NAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEP-------QDADVTSGNTVYFTC 267
Query: 263 LLTGGDPLPQLQWSHGPGPLPLGA-----LAQGGTLSIPSVQARDSGYYNCTATNNVGNP 317
G +P P++ W L + L GTL I + Q D G Y C A N G
Sbjct: 268 RAEG-NPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEV 326
Query: 318 AKKTVNL-LVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGK 376
+ V L S TF I P ++ + +G+ + L C P +++ W + +
Sbjct: 327 KTQEVTLRYFGSPARPTFVIQP----QNTEVLVGESVTLECSATGHPPPRIS--WTRGDR 380
Query: 377 -PARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISS 435
P + R+ +T + L + ++ D G Y C A+ + + I
Sbjct: 381 TPLPVDPRVNITPS--------GGLYIQNVVQGDSGEYACSAT---NNIDSVHATAFIIV 429
Query: 436 ETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETP 495
+ +P P+ R V+ EG + QCE +G P P + W++ + ++ L L
Sbjct: 430 QALPQFTVTPQDRVVI---EGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLS--- 483
Query: 496 DGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRP 555
G LR+ V+ G Y CQ G VQ V P D +G
Sbjct: 484 SGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRV--TPVFASIPSDTTVEVGAN 541
Query: 556 VLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYEC 615
V L CS +G P+ + W G + + E L ++ V +G YEC
Sbjct: 542 VQLPCS-SQGEPE--PAITWNKDGVQVTESGKFHISPE----GFLTINDVGPADAGRYEC 594
Query: 616 SVSNDVGSAA 625
N +GSA+
Sbjct: 595 VARNTIGSAS 604
Score = 70.1 bits (170), Expect = 9e-12
Identities = 69/305 (22%), Positives = 108/305 (35%), Gaps = 23/305 (7%)
Query: 343 ESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLEL 402
+ ++ G + +C + P+ ++ W +N M + D + ++ E
Sbjct: 253 QDADVTSGNTVYFTCRAEGNPKPEII--WLRNNNELSMKTDSRLNLLDDGTLMIQNTQE- 309
Query: 403 IDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQ 462
+D G Y CMA V V + PT + V V G L+
Sbjct: 310 -----TDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLV--GESVTLE 362
Query: 463 CEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGF 522
C G P P + W+R D+ LP + TP G L ++ V + SG Y C
Sbjct: 363 CSATGHPPPRISWTRGDRTP--LPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN---- 416
Query: 523 NVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLL 582
N+ A + VQ P+ + QD G+ V +C P IA W G L
Sbjct: 417 NIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIA---WTKGGSQL 473
Query: 583 PPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFD 642
V LR+ V G YEC N +GS + ++ + +
Sbjct: 474 S----VDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFAS 529
Query: 643 TPNPT 647
P+ T
Sbjct: 530 IPSDT 534
Score = 49.3 bits (116), Expect = 2e-05
Identities = 49/204 (24%), Positives = 79/204 (38%), Gaps = 33/204 (16%)
Query: 30 VHAGQACVVK---EDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQET 86
VHA +V+ + ++ + + EG T+ QC G+P P + WTK S +
Sbjct: 421 VHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHL 480
Query: 87 SVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGN 146
+ + TLRI +A G+Y C+A N +G + + LTV V+ V +
Sbjct: 481 VLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVA-----------HLTVQPRVTPVFAS 529
Query: 147 FYQEKT------VFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEP-LYTQGETKVL 199
+ T V L C+ P W + +GV + E + L
Sbjct: 530 IPSDTTVEVGANVQLPCSSQGEPEPAITWNK----------DGVQVTESGKFHISPEGFL 579
Query: 200 KLKNLRPQDYASYTCQVSVRNVCG 223
+ ++ P D Y C RN G
Sbjct: 580 TINDVGPADAGRYEC--VARNTIG 601
>gi|139948432 adlican [Homo sapiens]
Length = 2828
Score = 113 bits (283), Expect = 7e-25
Identities = 139/616 (22%), Positives = 242/616 (39%), Gaps = 75/616 (12%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRWT-------KTAGSASDKFQETSVFNETLRIERIART 101
T+ GDT+ ++CL G P PQ+ W +T + T N TL I+ + +
Sbjct: 1961 TVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRI--TLHENRTLSIKEASFS 2018
Query: 102 QGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNS 161
G Y C A N G ++ +IR+ V L P + + + ++ + ++ + CT +
Sbjct: 2019 DRGVYKCVASNAAGADSL-AIRLHVAAL--PPVIHQEKLENI--SLPPGLSIHIHCTAKA 2073
Query: 162 NPPARFIWKRGSDT-LSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRN 220
P W G T + SQ +++ ++ G L ++NL P+D Y C + N
Sbjct: 2074 APLPSVRWVLGDGTQIRPSQFLHGNLF--VFPNG---TLYIRNLAPKDSGRYECVAA--N 2126
Query: 221 VCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPG 280
+ G + + + A + + V G + + C GDP P++ W P
Sbjct: 2127 LVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDC-SASGDPWPRILW-RLPS 2184
Query: 281 PLPLGALAQ---------GGTLSIPSVQARDSGYYNCTATNNVGNP-AKKTVNLLVRSMK 330
+ AL GTL + SV +D+G Y C A N VG+ V+++++ K
Sbjct: 2185 KRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAK 2244
Query: 331 NATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTY---------QWFKNGKPARMS 381
+ + + G DLK+ C +P ++++ + ++ +
Sbjct: 2245 IEHKE------ENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRT 2298
Query: 382 KRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPT 441
KR +V N +L ++ + G Y C A V + V + T P T
Sbjct: 2299 KRYVVFNN--------GTLYFNEVGMREEGDYTCFAE---NQVGKDEMRVRVKVVTAPAT 2347
Query: 442 ISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLW-SRVDKEAALLPSGLPLEETPDGKLR 500
I K V V G + CE +G+P P V W S +K + S + DG L
Sbjct: 2348 IR-NKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNK--VIPTSSEKYQIYQDGTLL 2404
Query: 501 LERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVR-----QALGRP 555
+++ R SG Y C N + + +NVQ PP++ + + A G
Sbjct: 2405 IQKAQRSDSGNYTCLVR--NSAGEDRKTVWIHVNVQ-PPKINGNPNPITTVREIAAGGSR 2461
Query: 556 VLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYEC 615
L+ C G P +W F ++ P P + L + ++ + S C
Sbjct: 2462 KLIDCK-AEGIP--TPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVC 2518
Query: 616 SVSNDVGSAACLFQVS 631
N+ G A + Q++
Sbjct: 2519 MARNEGGEARLILQLT 2534
Score = 110 bits (276), Expect = 5e-24
Identities = 153/628 (24%), Positives = 232/628 (36%), Gaps = 63/628 (10%)
Query: 44 SERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKF----QETSVF-NETLRIERI 98
S R +R G TL L C +G P P++ W + D VF N TL ++ +
Sbjct: 2152 SPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSV 2211
Query: 99 ARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCT 158
G Y C A N VG + ++VDV + +P H+ +D + + + V T
Sbjct: 2212 TDKDAGDYLCVARNKVGDDYV-VLKVDV--VMKPAKIEHKEENDHKVFYGGDLKVDCVAT 2268
Query: 159 VNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSV 218
NP + GS S Q + Y L + ++ YTC
Sbjct: 2269 GLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTC--FA 2326
Query: 219 RNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQW-SH 277
N G + + R+ TAP ++ + V G+ VTV C G+P+P++ W S
Sbjct: 2327 ENQVGKDEMRV--RVKVVTAPATIRNKTYLAVQVPYGDVVTVAC-EAKGEPMPKVTWLSP 2383
Query: 278 GPGPLPLGA----LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNAT 333
+P + + Q GTL I Q DSG Y C N+ G +KTV + V +++
Sbjct: 2384 TNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGED-RKTVWIHV-NVQPPK 2441
Query: 334 FQITPDVIKESENIQLGQDLKL-SCHVDAVPQEKVTYQWFKNG--KPA-RMSKRLLVTRN 389
P+ I I G KL C + +P +V + F G PA R+ V N
Sbjct: 2442 INGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWA-FPEGVVLPAPYYGNRITVHGN 2500
Query: 390 DPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRA 449
SL++ L SD +CMA G L +++ + P P
Sbjct: 2501 --------GSLDIRSLRKSDSVQLVCMARNEGGEA-RLILQLTVLEPMEKPIFHDPISEK 2551
Query: 450 VVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLE---------ETPDGKLR 500
+T G L C G P P ++W +LP+G L+ DG L
Sbjct: 2552 -ITAMAGHTISLNCSAAGTPTPSLVW--------VLPNGTDLQSGQQLQRFYHKADGMLH 2602
Query: 501 LERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQAL-GRPVLLR 559
+ +S +G YRC G E V L V PE ++ + G + L
Sbjct: 2603 ISGLSSVDAGAYRCVARNAAGHT----ERLVSLKVGLKPEANKQYHNLVSIINGETLKLP 2658
Query: 560 CSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSN 619
C+ R + W + P D+ L + + G+Y C +
Sbjct: 2659 CTPPGAGQGRFS---WTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMET 2715
Query: 620 DVGSAACLFQVSAKAYSPEFYFDTPNPT 647
+ G + V AY P T PT
Sbjct: 2716 EYGPSVTSIPVIVIAYPPRI---TSEPT 2740
Score = 110 bits (274), Expect = 8e-24
Identities = 158/643 (24%), Positives = 239/643 (37%), Gaps = 96/643 (14%)
Query: 45 ERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSA----SDKFQETSVF-NETLRIERIA 99
+ V E DT+ C TG P+P V WTK + A + + Q V N TL I ++
Sbjct: 1861 QTVSVTAETDTVF-PCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQ 1919
Query: 100 RTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVS--DVRGNFYQEKTVFL-- 155
G+Y C A N G LD ++ + TV + + YQ+ TV+L
Sbjct: 1920 VQDRGQYMCTASNLHG-------------LDRMVVLLSVTVQQPQILASHYQDVTVYLGD 1966
Query: 156 ----RCTVNSNPPARFIW----KRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQ 207
C P + W +R T+S E T E + L +K
Sbjct: 1967 TIAMECLAKGTPAPQISWIFPDRRVWQTVSP--------VEGRITLHENRTLSIKEASFS 2018
Query: 208 DYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGG 267
D Y C S N G AI RL PP + E + + PG ++ + C
Sbjct: 2019 DRGVYKCVAS--NAAGADSLAI--RLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAA 2074
Query: 268 DPLPQLQWSHGPGPLPLGA--------LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAK 319
PLP ++W G G + + GTL I ++ +DSG Y C A N VG+ A+
Sbjct: 2075 -PLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGS-AR 2132
Query: 320 KTVNLLV-RSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPA 378
+TV L V R+ NA T +++ G LKL C P ++ ++ P+
Sbjct: 2133 RTVQLNVQRAAANARITGTS---PRRTDVRYGGTLKLDCSASGDPWPRILWR-----LPS 2184
Query: 379 RMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETV 438
+ L + + +L + + D G YLC+A V D V + +
Sbjct: 2185 KRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVAR---NKVGDDYVVLKVDVVMK 2241
Query: 439 PPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEET---- 494
P I K V G ++ C G P P + WS D +L+ S + +++
Sbjct: 2242 PAKIE-HKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPD--GSLVNSFMQSDDSGGRT 2298
Query: 495 ------PDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV--EPSSQ 546
+G L V G Y C G + E +V++ V P +
Sbjct: 2299 KRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKD----EMRVRVKVVTAPATIRNKTYL 2354
Query: 547 DVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAE---APDHAELRLD 603
V+ G V + C +G P + W L P V+P ++E L +
Sbjct: 2355 AVQVPYGDVVTVACE-AKGEP--MPKVTW-----LSPTNKVIPTSSEKYQIYQDGTLLIQ 2406
Query: 604 AVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNP 646
R SG+Y C V N G + P+ PNP
Sbjct: 2407 KAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKIN-GNPNP 2448
Score = 90.1 bits (222), Expect = 9e-18
Identities = 145/628 (23%), Positives = 233/628 (37%), Gaps = 100/628 (15%)
Query: 39 KEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETS----------V 88
KE+N + Y G L + C+ TG P P++ W+ GS + F ++ V
Sbjct: 2248 KEENDHKVFY----GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVV 2303
Query: 89 FNE-TLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNF 147
FN TL + + G Y C AEN VG +RV V+ + P ++T V+ +
Sbjct: 2304 FNNGTLYFNEVGMREEGDYTCFAENQVGK---DEMRVRVKVVTAPATIRNKTYLAVQVPY 2360
Query: 148 YQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQ 207
TV C P + W ++ + + IY + L ++ +
Sbjct: 2361 GDVVTV--ACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIY-------QDGTLLIQKAQRS 2411
Query: 208 DYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNP----GENVTVQCL 263
D +YTC VRN G K + + PP + + N V G + C
Sbjct: 2412 DSGNYTC--LVRNSAGEDRKTVWIHV--NVQPPKINGNPNPITTVREIAAGGSRKLIDC- 2466
Query: 264 LTGGDPLPQLQWSHGPG---PLPLG----ALAQGGTLSIPSVQARDSGYYNCTATNNVGN 316
G P P++ W+ G P P + G+L I S++ DS C A N G
Sbjct: 2467 KAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNE-GG 2525
Query: 317 PAKKTVNLLV-RSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNG 375
A+ + L V M+ F D I E G + L+C P + + NG
Sbjct: 2526 EARLILQLTVLEPMEKPIFH---DPISEKITAMAGHTISLNCSAAGTPTPSLVWV-LPNG 2581
Query: 376 KPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMA-SFPGAPVPDLSVEVNIS 434
+ ++L + + L + L D G Y C+A + G +S++V +
Sbjct: 2582 TDLQSGQQLQRFYHKAD-----GMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLK 2636
Query: 435 SETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEE- 493
E + + +V++ G +L C G + W+ LP+G+ LE
Sbjct: 2637 PE------ANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWT--------LPNGMHLEGP 2682
Query: 494 --------TPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV--EP 543
+G L + S GTY C+ G +V V + +PP + EP
Sbjct: 2683 QTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIV---IAYPPRITSEP 2739
Query: 544 SSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEA--------P 595
+ + G V L C + G P+ A W LP + A +A
Sbjct: 2740 TPV-IYTRPGNTVKLNC-MAMGIPK--ADITWE-----LPDKSHLKAGVQARLYGNRFLH 2790
Query: 596 DHAELRLDAVTRDSSGSYECSVSNDVGS 623
L + T+ +G Y+C N +GS
Sbjct: 2791 PQGSLTIQHATQRDAGFYKCMAKNILGS 2818
Score = 72.0 bits (175), Expect = 2e-12
Identities = 78/305 (25%), Positives = 117/305 (38%), Gaps = 51/305 (16%)
Query: 41 DNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF----NETLRIE 96
D ISE++ T G T+ L C G P P + W G+ Q+ F + L I
Sbjct: 2546 DPISEKI-TAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHIS 2604
Query: 97 RIARTQGGRYYCKAENGVG-VPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFL 155
++ G Y C A N G + S++V ++ E H VS + G +T+ L
Sbjct: 2605 GLSSVDAGAYRCVARNAAGHTERLVSLKVGLK--PEANKQYHNLVSIING-----ETLKL 2657
Query: 156 RCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQ-----DYA 210
CT RF W + NG+ + P T G +L L + D
Sbjct: 2658 PCTPPGAGQGRFSW---------TLPNGMHLEGP-QTLGRVSLLDNGTLTVREASVFDRG 2707
Query: 211 SYTCQVSVR---NVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGG 267
+Y C++ +V IP I + PP + + PG V + C+ G
Sbjct: 2708 TYVCRMETEYGPSVTSIPVIVIAY-------PPRITSEPTPVIYTRPGNTVKLNCMAMG- 2759
Query: 268 DPLPQLQWSHGPGPLPLGALAQG-----------GTLSIPSVQARDSGYYNCTATNNVGN 316
P + W P L A Q G+L+I RD+G+Y C A N +G+
Sbjct: 2760 IPKADITWEL-PDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGS 2818
Query: 317 PAKKT 321
+K T
Sbjct: 2819 DSKTT 2823
Score = 65.1 bits (157), Expect = 3e-10
Identities = 104/421 (24%), Positives = 161/421 (38%), Gaps = 67/421 (15%)
Query: 240 PALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALA----------- 288
P + +T+ V + C TG P P + W+ + GAL
Sbjct: 1853 PQILTKSPQTVSVTAETDTVFPCEATG-KPKPFVTWTK----VSTGALMTPNTRIQRFEV 1907
Query: 289 -QGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIK---ES 344
+ GTL I VQ +D G Y CTA+N G + V LL + T Q P ++ +
Sbjct: 1908 LKNGTLVIRKVQVQDRGQYMCTASNLHG--LDRMVVLL-----SVTVQ-QPQILASHYQD 1959
Query: 345 ENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELID 404
+ LG + + C P ++++ + P R + + +L + +
Sbjct: 1960 VTVYLGDTIAMECLAKGTPAPQISWIF-----PDRRVWQTVSPVEGRITLHENRTLSIKE 2014
Query: 405 LHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCE 464
FSD G Y C+AS A L++ +++++ +PP I K +++ G + C
Sbjct: 2015 ASFSDRGVYKCVAS-NAAGADSLAIRLHVAA--LPPVIHQEK-LENISLPPGLSIHIHCT 2070
Query: 465 VRGKPRPPVLWSRVDKEAALLPSGL---PLEETPDGKLRLERVSRDMSGTYRCQTARYNG 521
+ P P V W D + PS L P+G L + ++ SG Y C A G
Sbjct: 2071 AKAAPLPSVRWVLGD-GTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVG 2129
Query: 522 FNVRPREAQVQLNVQFPPE------VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW 575
R VQLNVQ P DVR G + L CS RI +W
Sbjct: 2130 SARR----TVQLNVQRAAANARITGTSPRRTDVR--YGGTLKLDCSASGDPWPRI---LW 2180
Query: 576 RFKGQLLPPPPVVPAAAEAPD------HAELRLDAVTRDSSGSYECSVSNDVGSAACLFQ 629
R LP ++ A + L + +VT +G Y C N VG + +
Sbjct: 2181 R-----LPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLK 2235
Query: 630 V 630
V
Sbjct: 2236 V 2236
Score = 56.6 bits (135), Expect = 1e-07
Identities = 59/219 (26%), Positives = 88/219 (40%), Gaps = 24/219 (10%)
Query: 106 YYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPA 165
YY + + + R + EP V + + + G Q L C V ++
Sbjct: 455 YYTQYSQTISTKDTRQARGRSWVMIEPSGAVQRDQTVLEGGPCQ-----LSCNVKASESP 509
Query: 166 RFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIP 225
W ++ + + D + + G L++K++ P D Y C VR+
Sbjct: 510 SIFWVLPDGSILKAPMDDPDSKFSILSSGW---LRIKSMEPSDSGLYQCIAQVRDEM--- 563
Query: 226 DKAITFRLTNT-TAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPL 284
D+ + L + + PA K +V T+ NPGE+VT+ C P L W P +
Sbjct: 564 DRMVYRVLVQSPSTQPAEKDTV--TIGKNPGESVTLPCNALA-IPEAHLSWIL-PNRRII 619
Query: 285 GALAQ--------GGTLSIPSVQARDSGYYNCTATNNVG 315
LA GTLSIP VQ DSGYY C A N G
Sbjct: 620 NDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
Score = 55.1 bits (131), Expect = 3e-07
Identities = 60/254 (23%), Positives = 103/254 (40%), Gaps = 14/254 (5%)
Query: 388 RNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKG 447
+N P + + SS+ I G++ +S A P S ++ + P I + K
Sbjct: 1804 QNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEK---PQI-LTKS 1859
Query: 448 RAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSG--LPLEETPDGKLRLERVS 505
V+V + CE GKP+P V W++V A + P+ E +G L + +V
Sbjct: 1860 PQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQ 1919
Query: 506 RDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRG 565
G Y C + +G + + + VQ P + QDV LG + + C L +G
Sbjct: 1920 VQDRGQYMCTASNLHGLD--RMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMEC-LAKG 1976
Query: 566 SPQRIASAVW--RFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGS 623
+P S ++ R Q + P V ++ L + + G Y+C SN G+
Sbjct: 1977 TPAPQISWIFPDRRVWQTVSP---VEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGA 2033
Query: 624 AACLFQVSAKAYSP 637
+ ++ A P
Sbjct: 2034 DSLAIRLHVAALPP 2047
Score = 45.4 bits (106), Expect = 2e-04
Identities = 85/393 (21%), Positives = 147/393 (37%), Gaps = 39/393 (9%)
Query: 265 TGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPS-VQARDSGYYNCTATNNVGNPAKKTVN 323
T G P LQ +P+ + Q I S VQ+ S + + + G PA K +
Sbjct: 1795 TTGSPSTNLQ------NIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWS 1848
Query: 324 LLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKR 383
L + T V E++ + C P+ VT W K A M+
Sbjct: 1849 LGEKPQILTKSPQTVSVTAETDTV-------FPCEATGKPKPFVT--WTKVSTGALMTPN 1899
Query: 384 LLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTIS 443
+ R + +L + + D G Y+C AS + L V + S TV
Sbjct: 1900 TRIQRFEV---LKNGTLVIRKVQVQDRGQYMCTAS----NLHGLDRMVVLLSVTVQQPQI 1952
Query: 444 VPKGRAVVTVREGSPAELQCEVRGKPRPPVLW----SRVDKEAALLPSGLPLEETPDGKL 499
+ VTV G ++C +G P P + W RV + + + + L E + L
Sbjct: 1953 LASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHE--NRTL 2010
Query: 500 RLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV--EPSSQDVRQALGRPVL 557
++ S G Y+C + G + ++L+V P V + +++ G +
Sbjct: 2011 SIKEASFSDRGVYKCVASNAAGAD----SLAIRLHVAALPPVIHQEKLENISLPPGLSIH 2066
Query: 558 LRCSLLRGSPQRIASAVWRF-KGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECS 616
+ C+ + +P + S W G + P + + L + + SG YEC
Sbjct: 2067 IHCTA-KAAP--LPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECV 2123
Query: 617 VSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRS 649
+N VGSA Q++ + + +P R+
Sbjct: 2124 AANLVGSARRTVQLNVQRAAANARITGTSPRRT 2156
Score = 39.3 bits (90), Expect = 0.018
Identities = 44/183 (24%), Positives = 66/183 (36%), Gaps = 24/183 (13%)
Query: 452 TVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLP---LEETPDGKLRLERVSRDM 508
TV EG P +L C V+ P + W D P P G LR++ +
Sbjct: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
Query: 509 SGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQD---VRQALGRPVLLRCSLLRG 565
SG Y+C + + VQ P +P+ +D + + G V L C+ L
Sbjct: 550 SGLYQCIAQVRDEMDRMVYRVLVQ-----SPSTQPAEKDTVTIGKNPGESVTLPCNAL-A 603
Query: 566 SPQRIASAVWRFKGQLLPPPPVVPAAAEAP-----DHAELRLDAVTRDSSGSYECSVSND 620
P+ A W +LP ++ A + L + V SG Y C N
Sbjct: 604 IPE--AHLSW-----ILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQ 656
Query: 621 VGS 623
G+
Sbjct: 657 QGA 659
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 110 bits (274), Expect = 8e-24
Identities = 141/639 (22%), Positives = 233/639 (36%), Gaps = 81/639 (12%)
Query: 44 SERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF-----NETLRIERI 98
S++ + GD L+L C TG P+PQ+ W + + D+ + N +L I +
Sbjct: 1947 SQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSV 2006
Query: 99 ARTQGGRYYCKAENGVGVPAI---KSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFL 155
G Y C A N +G I S+R+ +D Q + G +Q +
Sbjct: 2007 TEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQV---LHGKDFQ-----V 2058
Query: 156 RCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPL--YTQGETKVLKLKNLRPQDYASYT 213
C + +P W T+ ++ D YT L + + YT
Sbjct: 2059 DCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYT 2118
Query: 214 CQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQL 273
C +N G + + LT TA P ++ S + G+ + C +T GDP P++
Sbjct: 2119 CY--AQNTLGKDEMKV--HLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT-GDPKPKI 2173
Query: 274 QWSHGPGPLPLGALAQ-----GGTLSIPSVQARDSGYYNCTATNNVGNPAKK------TV 322
W + ++ + G+L+I V+ DSG Y C A N G+ K +
Sbjct: 2174 FWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSK 2233
Query: 323 NLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKN--GKPARM 380
L+ + I ++ S+ C + P +V + N
Sbjct: 2234 PPLINGLYTNRTVIKATAVRHSKK-------HFDCRAEGTPSPEVMWIMPDNIFLTAPYY 2286
Query: 381 SKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPP 440
R+ V +N +LE+ ++ SD ++C+A G L V++ + P
Sbjct: 2287 GSRITVHKN--------GTLEIRNVRLSDSADFICVARNEGGE-SVLVVQLEVLEMLRRP 2337
Query: 441 TISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETP----- 495
T P +V + G L C V G P P ++W +LP+G P
Sbjct: 2338 TFRNPFNEKIV-AQLGKSTALNCSVDGNPPPEIIW--------ILPNGTRFSNGPQSYQY 2388
Query: 496 ----DGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNV-QFPPEVEPSSQDVRQ 550
+G + + +R+ +G YRC G+ E V L + Q P + + V+
Sbjct: 2389 LIASNGSFIISKTTREDAGKYRCAARNKVGY----IEKLVILEIGQKPVILTYAPGTVKG 2444
Query: 551 ALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSS 610
G + L C + G P+ + W + P + D+ L + T
Sbjct: 2445 ISGESLSLHC-VSDGIPK--PNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDR 2501
Query: 611 GSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRS 649
G+Y C N VG V AY P T P RS
Sbjct: 2502 GNYICKAQNSVGHTLITVPVMIVAYPPRI---TNRPPRS 2537
Score = 105 bits (262), Expect = 2e-22
Identities = 112/485 (23%), Positives = 179/485 (36%), Gaps = 52/485 (10%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVF--NETLRIERIARTQGGRYY 107
I+ GDT +L C VTG P+P++ W + + F N +L I ++ G Y
Sbjct: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYV 2212
Query: 108 CKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARF 167
C A N G K ++DV + ++ + ++ + C P
Sbjct: 2213 CVARNPSGDDT-KMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEV 2271
Query: 168 IWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDK 227
+W + + G I T + L+++N+R D A + C RN G
Sbjct: 2272 MWIMPDNIFLTAPYYGSRI-----TVHKNGTLEIRNVRLSDSADFICVA--RNEGGESVL 2324
Query: 228 AITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQW--------SHGP 279
+ + P + NE +V G++ + C + G P P++ W S+GP
Sbjct: 2325 VVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPP-PEIIWILPNGTRFSNGP 2383
Query: 280 GPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPD 339
+A G+ I D+G Y C A N VG K + L K P
Sbjct: 2384 QSYQY-LIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVI--LEIGQKPVILTYAPG 2440
Query: 340 VIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTR---NDPELPAV 396
+K G+ L L C D +P+ + + M +V R N +
Sbjct: 2441 TVKGIS----GESLSLHCVSDGIPKPNIKWT---------MPSGYVVDRPQINGKYILHD 2487
Query: 397 TSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREG 456
+L + + D G Y+C A V + V + PP I+ R++VT R G
Sbjct: 2488 NGTLVIKEATAYDRGNYICKAQ---NSVGHTLITVPVMIVAYPPRITNRPPRSIVT-RTG 2543
Query: 457 SPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETP-------DGKLRLERVSRDMS 509
+ +L C G P+P + W D L S E T G L ++ S
Sbjct: 2544 AAFQLHCVALGVPKPEITWEMPDHS---LLSTASKERTHGSEQLHLQGTLVIQNPQTSDS 2600
Query: 510 GTYRC 514
G Y+C
Sbjct: 2601 GIYKC 2605
Score = 94.7 bits (234), Expect = 4e-19
Identities = 102/386 (26%), Positives = 158/386 (40%), Gaps = 44/386 (11%)
Query: 267 GDPLPQLQWSHGPGPLPLGALAQG--------GTLSIPSVQARDSGYYNCTATNNVG--- 315
G+PLP + W+ P L L Q GTLSI V+ +D G Y C+A+N G
Sbjct: 1674 GNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDH 1733
Query: 316 -NPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKN 374
+ V+ R ++ T +IT + G ++L C + P VT+
Sbjct: 1734 LHVTLSVVSYPPRILERRTKEIT---------VHSGSTVELKCRAEGRPSPTVTWILANQ 1784
Query: 375 ---GKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEV 431
+ ++ S++ +VT V +L L +L D G Y C+AS PG S+ V
Sbjct: 1785 TVVSESSQGSRQAVVT--------VDGTLVLHNLSIYDRGFYKCVASNPGG---QDSLLV 1833
Query: 432 NISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVD--KEAALLPSGL 489
I PP I + + R V+ G +L C +G P+P V W D + L +
Sbjct: 1834 KIQVIAAPPVI-LEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNS 1892
Query: 490 PLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVR 549
L +G L + ++ GTY C G R ++ V P +E +SQ
Sbjct: 1893 KLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVT-SPRIEAASQKRT 1951
Query: 550 QA-LGRPVLLRCSLLRGSPQRIASAVWRFKGQ-LLPPPPVVPAAAEAPDHAELRLDAVTR 607
+ G +LL CS G P+ +WR + ++ V + + L + +VT
Sbjct: 1952 EVNFGDKLLLNCS-ATGEPK--PQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTE 2008
Query: 608 DSSGSYECSVSNDVGSAACLFQVSAK 633
SG Y C N +G L VS +
Sbjct: 2009 KDSGVYLCVARNKMGDDLILMHVSLR 2034
Score = 94.7 bits (234), Expect = 4e-19
Identities = 128/623 (20%), Positives = 230/623 (36%), Gaps = 91/623 (14%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRW-----TKTAGSASDKFQETSVFNETLRIERIARTQG 103
T+ G T+ L+C G P P V W T + S+ Q + TL + ++
Sbjct: 1756 TVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDR 1815
Query: 104 GRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNP 163
G Y C A N G S+ V +Q + P + + Q + G + +++ L CT P
Sbjct: 1816 GFYKCVASNPGGQ---DSLLVKIQVIAAPPVILEQRRQVIVGTW--GESLKLPCTAKGTP 1870
Query: 164 PARFIWKRGSDT-LSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVC 222
W T + Q ++ L++ G L ++NL D +Y C + +
Sbjct: 1871 QPSVYWVLSDGTEVKPLQFTNSKLF--LFSNG---TLYIRNLASSDRGTYECIAT--SST 1923
Query: 223 GIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPL 282
G + + + P ++ + + VN G+ + + C T G+P PQ+ W L
Sbjct: 1924 GSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSAT-GEPKPQIMWR-----L 1977
Query: 283 PLGALAQ-------------GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSM 329
P A+ G+L I SV +DSG Y C A N +G+ +
Sbjct: 1978 PSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDL---------IL 2028
Query: 330 KNATFQITPDVIKESE----NIQLGQDLKLSCHVDAVPQEKVTYQ-----WFKNGKPA-- 378
+ + ++ P I + + G+D ++ C P ++++ N A
Sbjct: 2029 MHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADD 2088
Query: 379 --RMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSE 436
++R + N +L + ++ G Y C A + ++V+++
Sbjct: 2089 SGHRTRRYTLFNN--------GTLYFNKVGVAEEGDYTCYAQ---NTLGKDEMKVHLTVI 2137
Query: 437 TVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPD 496
T P I + ++ G A L CEV G P+P + W LLPS + + D
Sbjct: 2138 TAAPRIR-QSNKTNKRIKAGDTAVLDCEVTGDPKPKIFW--------LLPSNDMISFSID 2188
Query: 497 -------GKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEP--SSQD 547
G L + +V SG Y C +G + + + V V PP + +++
Sbjct: 2189 RYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV---VSKPPLINGLYTNRT 2245
Query: 548 VRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTR 607
V +A + R +W + P + + L + V
Sbjct: 2246 VIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRL 2305
Query: 608 DSSGSYECSVSNDVGSAACLFQV 630
S + C N+ G + + Q+
Sbjct: 2306 SDSADFICVARNEGGESVLVVQL 2328
Score = 94.4 bits (233), Expect = 5e-19
Identities = 139/621 (22%), Positives = 239/621 (38%), Gaps = 74/621 (11%)
Query: 48 YTIREGDTLMLQCLVTGHPRPQVRWTKT-AGSASDKFQETS----VFNETLRIERIARTQ 102
+TI L C G+P P + WT+ +G K ++ S + N TL I+R+
Sbjct: 1658 FTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQD 1717
Query: 103 GGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSN 162
G+Y C A N G + V + + P + + ++ + TV L+C
Sbjct: 1718 RGQYLCSASNLFGT---DHLHVTLSVVSYPPRILERRTKEI--TVHSGSTVELKCRAEGR 1772
Query: 163 PPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVC 222
P W + T+ G + + T T L L NL D Y C S N
Sbjct: 1773 PSPTVTWILANQTVVSESSQG--SRQAVVTVDGT--LVLHNLSIYDRGFYKCVAS--NPG 1826
Query: 223 GIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQW--SHGPG 280
G ++ ++ APP + + +V GE++ + C G P P + W S G
Sbjct: 1827 G--QDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPC-TAKGTPQPSVYWVLSDGTE 1883
Query: 281 PLPLG------ALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATF 334
PL L GTL I ++ + D G Y C AT++ G +++ V +L + +
Sbjct: 1884 VKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTG--SERRVVMLTMEERVTSP 1941
Query: 335 QITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNG---KPARMSKRLLVTRNDP 391
+I K +E + G L L+C P+ ++ ++ + R+ + V N
Sbjct: 1942 RIEAASQKRTE-VNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPN-- 1998
Query: 392 ELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVV 451
SL + + D G YLC+A + D + +++S P I K
Sbjct: 1999 ------GSLFIGSVTEKDSGVYLCVAR---NKMGDDLILMHVSLRLKPAKID-HKQYFRK 2048
Query: 452 TVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEET----------PDGKLRL 501
V G ++ C+ G P P + WS D ++ + + +++ +G L
Sbjct: 2049 QVLHGKDFQVDCKASGSPVPEISWSLPD--GTMINNAMQADDSGHRTRRYTLFNNGTLYF 2106
Query: 502 ERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNV-QFPPEVEPSSQ-DVRQALGRPVLLR 559
+V G Y C G + E +V L V P + S++ + R G +L
Sbjct: 2107 NKVGVAEEGDYTCYAQNTLGKD----EMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLD 2162
Query: 560 CSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEA---PDHAELRLDAVTRDSSGSYECS 616
C + G P+ W LLP ++ + + + L ++ V SG Y C
Sbjct: 2163 CE-VTGDPK--PKIFW-----LLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCV 2214
Query: 617 VSNDVGSAACLFQVSAKAYSP 637
N G ++++ + P
Sbjct: 2215 ARNPSGDDTKMYKLDVVSKPP 2235
Score = 78.6 bits (192), Expect = 3e-14
Identities = 138/630 (21%), Positives = 230/630 (36%), Gaps = 106/630 (16%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGS-------ASDKFQETSVF----NETLRIERI 98
+ G + C +G P P++ W+ G+ A D T + N TL ++
Sbjct: 2050 VLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKV 2109
Query: 99 ARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCT 158
+ G Y C A+N +G +K + + V + ++T ++ T L C
Sbjct: 2110 GVAEEGDYTCYAQNTLGKDEMK-VHLTVITAAPRIRQSNKTNKRIKAG----DTAVLDCE 2164
Query: 159 VNSNPPARFIWKRGS-DTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVS 217
V +P + W S D +S S D YT L + ++ D Y C
Sbjct: 2165 VTGDPKPKIFWLLPSNDMISFSIDR--------YTFHANGSLTINKVKLLDSGEYVCVA- 2215
Query: 218 VRNVCGIPDKAITFRLTNTTAPPALK-LSVNETLVVNPGENVTVQCL--LTGGDPLPQLQ 274
RN G D ++L + PP + L N T++ + + G P P++
Sbjct: 2216 -RNPSG--DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVM 2272
Query: 275 WSHGPGPLPLGALAQG--------GTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLV 326
W P + L A G GTL I +V+ DS + C A N G ++
Sbjct: 2273 WIM-PDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVL 2331
Query: 327 RSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTY-----QWFKNGKPARMS 381
++ TF+ + E QLG+ L+C VD P ++ + F NG S
Sbjct: 2332 EMLRRPTFR---NPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGP---QS 2385
Query: 382 KRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPT 441
+ L+ N + + T+ D G Y C A + L + + I + V T
Sbjct: 2386 YQYLIASNGSFIISKTTR--------EDAGKYRCAARNKVGYIEKLVI-LEIGQKPVILT 2436
Query: 442 ISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETP------ 495
+ + + G L C G P+P + W+ +PSG ++
Sbjct: 2437 YAPGTVKGI----SGESLSLHCVSDGIPKPNIKWT--------MPSGYVVDRPQINGKYI 2484
Query: 496 ---DGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEV-EPSSQDVRQA 551
+G L ++ + G Y C+ G + + V +PP + + +
Sbjct: 2485 LHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMI---VAYPPRITNRPPRSIVTR 2541
Query: 552 LGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRL--------- 602
G L C L G P+ W +P ++ A++ H +L
Sbjct: 2542 TGAAFQLHCVAL-GVPK--PEITWE-----MPDHSLLSTASKERTHGSEQLHLQGTLVIQ 2593
Query: 603 DAVTRDSSGSYECSVSNDVGS--AACLFQV 630
+ T DS G Y+C+ N +GS AA QV
Sbjct: 2594 NPQTSDS-GIYKCTAKNPLGSDYAATYIQV 2622
Score = 61.2 bits (147), Expect = 4e-09
Identities = 76/285 (26%), Positives = 115/285 (40%), Gaps = 21/285 (7%)
Query: 344 SENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELI 403
S I D L C +AV T W + +SKR +R LP T S++ +
Sbjct: 1657 SFTIPANSDAFLPC--EAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQV-LPNGTLSIQRV 1713
Query: 404 DLHFSDYGTYLCMAS-FPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQ 462
++ D G YLC AS G + V +S + PP I + + +TV GS EL+
Sbjct: 1714 EIQ--DRGQYLCSASNLFGTD----HLHVTLSVVSYPPRI-LERRTKEITVHSGSTVELK 1766
Query: 463 CEVRGKPRPPVLWSRVDKEAALLPS--GLPLEETPDGKLRLERVSRDMSGTYRCQTARYN 520
C G+P P V W ++ S T DG L L +S G Y+C +
Sbjct: 1767 CRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPG 1826
Query: 521 GFNVRPREAQVQLNVQFPPEV-EPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFK- 578
G + + QV + PP + E Q + G + L C+ +G+PQ S W
Sbjct: 1827 GQDSLLVKIQV---IAAPPVILEQRRQVIVGTWGESLKLPCT-AKGTPQ--PSVYWVLSD 1880
Query: 579 GQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGS 623
G + P + + L + + G+YEC ++ GS
Sbjct: 1881 GTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGS 1925
Score = 51.6 bits (122), Expect = 3e-06
Identities = 53/206 (25%), Positives = 84/206 (40%), Gaps = 36/206 (17%)
Query: 449 AVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEE---------TPDGKL 499
A T+ S A L CE G P P + W+RV PSGL L + P+G L
Sbjct: 1656 ASFTIPANSDAFLPCEAVGNPLPTIHWTRV-------PSGLDLSKRKQNSRVQVLPNGTL 1708
Query: 500 RLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLN-VQFPPEV-EPSSQDVRQALGRPVL 557
++RV G Y C + G + V L+ V +PP + E ++++ G V
Sbjct: 1709 SIQRVEIQDRGQYLCSASNLFGTD----HLHVTLSVVSYPPRILERRTKEITVHSGSTVE 1764
Query: 558 LRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDA------VTRDSSG 611
L+C R + + W +L VV +++ A + +D ++ G
Sbjct: 1765 LKC---RAEGRPSPTVTW-----ILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRG 1816
Query: 612 SYECSVSNDVGSAACLFQVSAKAYSP 637
Y+C SN G + L ++ A P
Sbjct: 1817 FYKCVASNPGGQDSLLVKIQVIAAPP 1842
Score = 38.1 bits (87), Expect = 0.040
Identities = 50/196 (25%), Positives = 75/196 (38%), Gaps = 32/196 (16%)
Query: 452 TVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLP----SGLPLEETPDGKLRLERVSRD 507
TV G L C +G P P V W D P G L + GKL L+
Sbjct: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILID-KSGKLELQMADSF 544
Query: 508 MSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQ-------ALGRPVLLRC 560
+G Y C ++ Y+ ++ V VEP + ++ +G + L C
Sbjct: 545 DTGVYHCISSNYDDADILTYRITV---------VEPLVEAYQENGIHHTVFIGETLDLPC 595
Query: 561 SLLRGSPQRIASAVWRFKGQLLPPPPVVPAAA---EAPDHAELRLDAVTRDSSGSYECSV 617
G P AS W ++P V+ ++ + ++ LR+ VT G Y C
Sbjct: 596 H-STGIPD--ASISW-----VIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVA 647
Query: 618 SNDVGSAACLFQVSAK 633
+N G +FQVS K
Sbjct: 648 ANPSGVDFLIFQVSVK 663
Score = 35.4 bits (80), Expect = 0.26
Identities = 38/171 (22%), Positives = 66/171 (38%), Gaps = 38/171 (22%)
Query: 267 GDPLPQLQWSHGPGPLPLGA---------LAQGGTLSIPSVQARDSGYYNCTATNNVGNP 317
GDP P + W G + + G L + + D+G Y+C ++N
Sbjct: 501 GDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSN----- 555
Query: 318 AKKTVNLLVRSMKNATFQIT---PDVIKESEN-----IQLGQDLKLSCHVDAVPQEKVTY 369
++L T++IT P V EN + +G+ L L CH +P +++
Sbjct: 556 -YDDADIL-------TYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISW 607
Query: 370 QWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP 420
N + S+ V N +L ++ + D G Y C+A+ P
Sbjct: 608 VIPGNNVLYQSSRDKKVLNN--------GTLRILQVTPKDQGYYRCVAANP 650
Score = 35.0 bits (79), Expect = 0.33
Identities = 41/185 (22%), Positives = 75/185 (40%), Gaps = 20/185 (10%)
Query: 37 VVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGS------ASDKFQETSVFN 90
++ DN ++ +T+ G T+ L C G P P V W GS S+ + +
Sbjct: 474 MISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKS 533
Query: 91 ETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQE 150
L ++ G Y+C + N I + R+ V EP++ +Q + + +
Sbjct: 534 GKLELQMADSFDTGVYHCISSN-YDDADILTYRITVV---EPLVEAYQE-NGIHHTVFIG 588
Query: 151 KTVFLRCTVNSNPPARFIWK-RGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDY 209
+T+ L C P A W G++ L S + + + G ++L+ + P+D
Sbjct: 589 ETLDLPCHSTGIPDASISWVIPGNNVLYQSSRD-----KKVLNNGTLRILQ---VTPKDQ 640
Query: 210 ASYTC 214
Y C
Sbjct: 641 GYYRC 645
Score = 34.3 bits (77), Expect = 0.57
Identities = 22/81 (27%), Positives = 30/81 (37%), Gaps = 7/81 (8%)
Query: 42 NISERVYTIREGDTLMLQCLVTGHPRPQVRW-------TKTAGSASDKFQETSVFNETLR 94
N R R G L C+ G P+P++ W TA E TL
Sbjct: 2532 NRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLV 2591
Query: 95 IERIARTQGGRYYCKAENGVG 115
I+ + G Y C A+N +G
Sbjct: 2592 IQNPQTSDSGIYKCTAKNPLG 2612
Score = 33.9 bits (76), Expect = 0.75
Identities = 23/71 (32%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Query: 48 YTIREGDTLMLQCLVTGHPRPQVRWTKTAGSAS-DKFQETSVFNE-TLRIERIARTQGGR 105
+T+ G+TL L C TG P + W + ++ V N TLRI ++ G
Sbjct: 583 HTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGY 642
Query: 106 YYCKAENGVGV 116
Y C A N GV
Sbjct: 643 YRCVAANPSGV 653
Score = 33.5 bits (75), Expect = 0.97
Identities = 36/146 (24%), Positives = 58/146 (39%), Gaps = 9/146 (6%)
Query: 397 TSSLELIDLHFSDYGTYLCMAS-FPGAPVPDLSVEVNISSETVPPTISVPKGRAVV-TVR 454
+ LEL D G Y C++S + A + + V V P + + + TV
Sbjct: 533 SGKLELQMADSFDTGVYHCISSNYDDADILTYRITV------VEPLVEAYQENGIHHTVF 586
Query: 455 EGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRC 514
G +L C G P + W + L S + +G LR+ +V+ G YRC
Sbjct: 587 IGETLDLPCHSTGIPDASISWV-IPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRC 645
Query: 515 QTARYNGFNVRPREAQVQLNVQFPPE 540
A +G + + V++ Q P E
Sbjct: 646 VAANPSGVDFLIFQVSVKMKGQRPLE 671
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 109 bits (273), Expect = 1e-23
Identities = 158/681 (23%), Positives = 262/681 (38%), Gaps = 92/681 (13%)
Query: 53 GDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAEN 112
G T+ L C +G+P P +RW K + T L I + G Y C+ N
Sbjct: 300 GHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT-GLTISDLRTEDSGTYICEVTN 358
Query: 113 GVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRG 172
G I + + L H T++ + TV L C + +P W R
Sbjct: 359 TFGSAEATGILMVIDPL-------HVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN 411
Query: 173 SDTLSHSQDNGVDIYEPLYTQG-ETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITF 231
++ + E + +G + L + + + +Y C + R D AI
Sbjct: 412 TELVLPD--------EAISIRGLSNETLLITSAQKSHSGAYQC-FATRKAQTAQDFAI-- 460
Query: 232 RLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLG------ 285
+ P + S +E VVNPGE ++ C G P P + W+ P+
Sbjct: 461 -IALEDGTPRIVSSFSEK-VVNPGEQFSLMCAAKGAPP-PTVTWALDDEPIVRDGSHRTN 517
Query: 286 --ALAQGGTLS---IPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDV 340
++ G T+S + Q RD G Y CTA N VG+ A+ + VR P
Sbjct: 518 QYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGS-AEYQARINVRG---------PPS 567
Query: 341 IKESENIQ--LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTS 398
I+ NI G+D ++C V P + +W+K+ LL+ N ++
Sbjct: 568 IRAMRNITAVAGRDTLINCRVIGYPYYSI--KWYKDA--------LLLPDNHRQVVFENG 617
Query: 399 SLELIDLHFS-DYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGS 457
+L+L D+ D G YLC P LS+ ++ P + P ++ G
Sbjct: 618 TLKLTDVQKGMDEGEYLCSVLIQ----PQLSISQSVHVAVKVPPLIQPFEFPPASI--GQ 671
Query: 458 PAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETP-DGKLRLERVSRDMSGTYRCQT 516
+ C V P + R D + + SG+ +E L++ VS +G Y C
Sbjct: 672 LLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIA 731
Query: 517 ARYNGFNVRPREAQVQLNVQFPPE--VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAV 574
+ R R QL V+ PP V+P++QD G+ +L CS+ P ++ +
Sbjct: 732 SNAAATVSRER----QLIVRVPPRFVVQPNNQD--GIYGKAGVLNCSVDGYPPPKV---M 782
Query: 575 WRF-KG----QLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQ 629
W+ KG Q P P+ P ++ L + V + G Y C SN VG+
Sbjct: 783 WKHAKGSGNPQQYHPVPLTGRIQILP-NSSLLIRHVLEEDIGYYLCQASNGVGTDISK-S 840
Query: 630 VSAKAYSPEFYFDTPNPT---RSHKLSKNYS------YVLQWTQREPDAVDPVLNYRLSI 680
+ P PN T + H N + +++W ++ +DP R +I
Sbjct: 841 MFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRW-EKGDTVIDPDRVMRYAI 899
Query: 681 RQLNQHNAVVKAIPVRRVEKG 701
+ + VV + ++ ++G
Sbjct: 900 ATKDNGDEVVSTLKLKPADRG 920
Score = 70.1 bits (170), Expect = 9e-12
Identities = 118/541 (21%), Positives = 210/541 (38%), Gaps = 70/541 (12%)
Query: 42 NISERVYTIREGDTLMLQCLVTGHPRPQVRWT----KTAGSASDKFQETSVFNET----L 93
+ SE+V + G+ L C G P P V W S + + ++ + T +
Sbjct: 473 SFSEKV--VNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHM 530
Query: 94 RIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTV 153
+ GG Y C A N VG A R++V+ P + + ++ V G +
Sbjct: 531 NVTGPQIRDGGVYRCTARNLVG-SAEYQARINVR--GPPSIRAMRNITAVAG-----RDT 582
Query: 154 FLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYT 213
+ C V P W + + L DN + ++ G K+ ++ + D Y
Sbjct: 583 LINCRVIGYPYYSIKWYKDALLL---PDNHRQV---VFENGTLKLTDVQ--KGMDEGEYL 634
Query: 214 CQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQL 273
C V ++ P +I+ + P L + E + G+ + + C+++ GD ++
Sbjct: 635 CSVLIQ-----PQLSISQSVHVAVKVPPL-IQPFEFPPASIGQLLYIPCVVSSGDMPIRI 688
Query: 274 QWS-------HGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLV 326
W G G + + + +L I SV + +G Y C A+N +++ L+V
Sbjct: 689 TWRKDGQVIISGSG-VTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRER-QLIV 746
Query: 327 RSMKNATFQITPDVIKESENIQ--LGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRL 384
R + P + + N G+ L+C VD P KV ++ K + +
Sbjct: 747 R--------VPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPV 798
Query: 385 LVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISV 444
+T LP SSL + + D G YLC AS D+S + ++ + S
Sbjct: 799 PLTGRIQILP--NSSLLIRHVLEEDIGYYLCQAS--NGVGTDISKSMFLTVKIPAMITSH 854
Query: 445 PKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVD---KEAALLPSGLPLEETPD---GK 498
P + +G EL C RG+ + W + D ++ + ++ D
Sbjct: 855 PNTTIAI---KGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVST 911
Query: 499 LRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLL 558
L+L+ R S + C G + +QL VQ PP +P ++R+ R + L
Sbjct: 912 LKLKPADRGDSVFFSCHAINSYGED----RGLIQLTVQEPP--DPPELEIREVKARSMNL 965
Query: 559 R 559
R
Sbjct: 966 R 966
Score = 45.1 bits (105), Expect = 3e-04
Identities = 33/95 (34%), Positives = 46/95 (48%), Gaps = 9/95 (9%)
Query: 240 PALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQG-------GT 292
PA +S T+ ++V + C G DP P ++W+ + G GT
Sbjct: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVG-DPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGT 1407
Query: 293 LSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVR 327
L + +V+A DSGYY CTAT N G VNLLV+
Sbjct: 1408 LLLRAVKAEDSGYYTCTAT-NTGGFDTIIVNLLVQ 1441
Score = 37.4 bits (85), Expect = 0.067
Identities = 38/129 (29%), Positives = 53/129 (41%), Gaps = 8/129 (6%)
Query: 414 LCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPV 473
L +A+ A + S +V I P + G VT L C G P P V
Sbjct: 1323 LWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFG-GTVTTPWMKDVRLPCNSVGDPAPAV 1381
Query: 474 LWSRVDKEAALLPS--GLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQV 531
W++ +++A+ S G L T +G L L V + SG Y C GF+ V
Sbjct: 1382 KWTKDSEDSAIPVSMDGHRLIHT-NGTLLLRAVKAEDSGYYTCTATNTGGFDT----IIV 1436
Query: 532 QLNVQFPPE 540
L VQ PP+
Sbjct: 1437 NLLVQVPPD 1445
Score = 34.3 bits (77), Expect = 0.57
Identities = 29/87 (33%), Positives = 37/87 (42%), Gaps = 6/87 (6%)
Query: 58 LQCLVTGHPRPQVRWTK----TAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENG 113
L C G P P V+WTK +A S N TL + + G Y C A N
Sbjct: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNT 1428
Query: 114 VGVPA-IKSIRVDVQYLDEPMLTVHQT 139
G I ++ V V D+P LTV +T
Sbjct: 1429 GGFDTIIVNLLVQVP-PDQPRLTVSKT 1454
>gi|205277425 immunoglobulin superfamily, member 9 isoform a [Homo
sapiens]
Length = 1179
Score = 108 bits (271), Expect = 2e-23
Identities = 121/456 (26%), Positives = 189/456 (41%), Gaps = 57/456 (12%)
Query: 199 LKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTT--APPALKLSVNETLVVNPGE 256
L+++ LR +D Y C+V + D + T +PP + + L V E
Sbjct: 93 LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELE 152
Query: 257 NVTVQCLLTGGDPLPQLQWSHGPGPLPLG---ALAQGGTLSIPSVQARDSGYYNCTATNN 313
VT++C+ G PLP + W L G Q GTL I V+ SG Y C A++
Sbjct: 153 PVTLRCVARGS-PLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASST 211
Query: 314 VGNPAKKTVNLLVRSMKNATFQITPDVI---KESENIQLGQDLKLSCHVDAVPQEKVTYQ 370
G+ T LLV + P VI ++ + QD+ L+CH +A P +TY
Sbjct: 212 EGSATHAT-QLLV---------LGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN-LTYS 260
Query: 371 WFKNGKPARMSKRLLVTRNDPELPA-VTSSLELIDLHFSDYGTYLCMAS----FPGAPVP 425
WF++ ++R P + V SL L+ D G Y C+ S P +
Sbjct: 261 WFQDNINV-----FHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASA 315
Query: 426 DLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVL---WSRVDKEA 482
L+V +PP +P G P ++C VR P P+L W++ D +A
Sbjct: 316 YLTVLYPAQVTAMPPETPLPIGM---------PGVIRCPVRANP--PLLFVSWTK-DGKA 363
Query: 483 ALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE-V 541
L + +G L + + D G Y C YN ++ ++ PP +
Sbjct: 364 LQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTP--YNSLGTAGPSPVTRVLLKAPPAFI 421
Query: 542 EPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELR 601
E ++ Q +GR +L+ CS +G P + S W G+ L A+ ++ L
Sbjct: 422 ERPKEEYFQEVGRELLIPCSA-QGDPPPVVS--WTKVGRGLQ------GQAQVDSNSSLI 472
Query: 602 LDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSP 637
L +T+++ G +ECS SN V A V SP
Sbjct: 473 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSP 508
Score = 65.1 bits (157), Expect = 3e-10
Identities = 106/423 (25%), Positives = 162/423 (38%), Gaps = 61/423 (14%)
Query: 47 VYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRY 106
V ++E + + L+C+ G P P V W + V N TLRI R+ R G Y
Sbjct: 145 VLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVY 204
Query: 107 YCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPAR 166
C+A + G + + L P++ V S V + + V L C + P
Sbjct: 205 TCQASSTEG---SATHATQLLVLGPPVIVVPPKNSTVNAS----QDVSLACHAEAYP--- 254
Query: 167 FIWKRGSDTLSHSQDNGVDIYEPLYTQGETKV-----LKLKNLRPQDYASYTCQVSVRNV 221
+ T S QDN ++++ Q ++ L+L +P D YTC S N
Sbjct: 255 -----ANLTYSWFQDN-INVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPS--NG 306
Query: 222 CGIPDKA-----ITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWS 276
P A + + T PP L + PG ++C + PL + W+
Sbjct: 307 LLHPPSASAYLTVLYPAQVTAMPPETPLPIG-----MPG---VIRCPVRANPPLLFVSWT 358
Query: 277 HGPGPLPLGAL---AQG--GTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKN 331
L L +QG G+L I G Y+CT N++G V ++
Sbjct: 359 KDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPP 418
Query: 332 ATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDP 391
A + KE ++G++L + C P V+ W K G+ + + V N
Sbjct: 419 AFIERP----KEEYFQEVGRELLIPCSAQGDPPPVVS--WTKVGR--GLQGQAQVDSN-- 468
Query: 392 ELPAVTSSLELIDLHFSDYGTYLCMASFPGAPV-PDLSVEVNISSETVPPTISV---PKG 447
SSL L L +G + C AS A V +V V +S V +SV PKG
Sbjct: 469 ------SSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKG 522
Query: 448 RAV 450
V
Sbjct: 523 ANV 525
Score = 64.7 bits (156), Expect = 4e-10
Identities = 67/247 (27%), Positives = 96/247 (38%), Gaps = 20/247 (8%)
Query: 398 SSLELIDLHFSDYGTYLCMASFPGAPVPDLSVE----VNISSETVPPTISVPKGRAVVTV 453
+SL++ L D G Y C F +P+ V+++ + P P AV+ V
Sbjct: 91 ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP--AVLEV 148
Query: 454 REGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYR 513
+E P L+C RG P P V W K+ L G + +G LR+ RV R SG Y
Sbjct: 149 QELEPVTLRCVARGSPLPHVTWKLRGKD---LGQGQGQVQVQNGTLRIRRVERGSSGVYT 205
Query: 514 CQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASA 573
CQ + G QL V PP + ++ + V L C P + +
Sbjct: 206 CQASSTEGSATH----ATQLLVLGPPVIVVPPKNSTVNASQDVSLACH-AEAYPANLTYS 260
Query: 574 VWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
++ + + P D LRL A D +G Y C SN + L SA
Sbjct: 261 WFQDNINVFHISRLQPRVRILVD-GSLRLLATQPDDAGCYTCVPSNGL-----LHPPSAS 314
Query: 634 AYSPEFY 640
AY Y
Sbjct: 315 AYLTVLY 321
Score = 58.2 bits (139), Expect = 4e-08
Identities = 92/407 (22%), Positives = 146/407 (35%), Gaps = 61/407 (14%)
Query: 249 TLVVNPGENVTVQCLL---TGGDPLPQLQWSHGPGPLPLGA------------------L 287
++V GE+V + C L G PL ++W LP+ L
Sbjct: 28 SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRL 87
Query: 288 AQGGTLSIPSVQARDSGYYNCTA--------TNNVGNPAKKTVNLLVRSMKNATFQITPD 339
+G +L I ++ D G+Y C ++ N + V+L V S FQ TP
Sbjct: 88 QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGS--WVHLTVNSPPQ--FQETPP 143
Query: 340 VIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSS 399
+ E + + + + L C P VT W GK + + +N +
Sbjct: 144 AVLEVQEL---EPVTLRCVARGSPLPHVT--WKLRGKDLGQGQGQVQVQN--------GT 190
Query: 400 LELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPA 459
L + + G Y C AS + + + PP I VP + TV
Sbjct: 191 LRIRRVERGSSGVYTCQASSTEGSATHATQLLVLG----PPVIVVPPKNS--TVNASQDV 244
Query: 460 ELQCEVRGKP-RPPVLWSRVDKEAALLPSGLP-LEETPDGKLRLERVSRDMSGTYRCQTA 517
L C P W + + + P + DG LRL D +G Y C +
Sbjct: 245 SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPS 304
Query: 518 RYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRF 577
NG + P A L V +P +V + +G P ++RC + P S W
Sbjct: 305 --NGL-LHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVS--WTK 359
Query: 578 KGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSA 624
G+ L P ++ + L + D+ G Y C+ N +G+A
Sbjct: 360 DGKALQLDK-FPGWSQGTE-GSLIIALGNEDALGEYSCTPYNSLGTA 404
>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor
[Homo sapiens]
Length = 1014
Score = 107 bits (267), Expect = 5e-23
Identities = 139/545 (25%), Positives = 206/545 (37%), Gaps = 67/545 (12%)
Query: 58 LQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNE--TLRIERIARTQGGRYYCKAENGVG 115
L+C + GHPRP +W + SD +V ++ L + G Y C A + G
Sbjct: 148 LRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFG 207
Query: 116 VPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDT 175
A S + DE V DV Y+E C ++ PP W +T
Sbjct: 208 -QACSSQNFTLSIADESFARVVLAPQDVVVARYEE--AMFHCQFSAQPPPSLQWLFEDET 264
Query: 176 LSHSQDNGVDIYE-PLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLT 234
++ + ++ G L L +RP++ Y C + I +A T L
Sbjct: 265 PITNRSRPPHLRRATVFANGS---LLLTQVRPRNAGIYRCIGQGQRGPPIILEA-TLHLA 320
Query: 235 NTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPL-GALAQ-GGT 292
P E V G V CL G P P + W H LP G + Q G
Sbjct: 321 EIEDMPLF-----EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHE 375
Query: 293 LSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQL--G 350
L + ++ D+G Y C A N G ++ VN+ V ++ P +K+ ++ QL G
Sbjct: 376 LVLANIAESDAGVYTCHAANLAGQ-RRQDVNITVATV--------PSWLKKPQDSQLEEG 426
Query: 351 QDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDY 410
+ L C A P K T W++N R V +N +L + + D
Sbjct: 427 KPGYLDCLTQATP--KPTVVWYRNQMLISEDSRFEVFKN--------GTLRINSVEVYDG 476
Query: 411 GTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPR 470
Y CM+S P S+E + + P + + A + C G+ +
Sbjct: 477 TWYRCMSSTPAG-----SIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREK 531
Query: 471 PPVLWSRVDKEAALLPSGLPLEETPD-GKLRLERVSRDMSGTYRCQTARYNGFNVRPREA 529
P + W R D S LP T + G L RV+RD +G Y C + +R A
Sbjct: 532 PTIKWERAD------GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIR---A 582
Query: 530 QVQLNVQ--FPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFK-------GQ 580
VQL V +VEP V Q G LL+C +G P+ + W+ K G
Sbjct: 583 HVQLTVAVFITFKVEPERTTVYQ--GHTALLQCE-AQGDPKPLIQ--WKDKPVPEESEGP 637
Query: 581 LLPPP 585
PPP
Sbjct: 638 GSPPP 642
Score = 82.8 bits (203), Expect = 1e-15
Identities = 129/585 (22%), Positives = 212/585 (36%), Gaps = 72/585 (12%)
Query: 52 EGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQ-GGRYYCKA 110
+G +L+C V V W D + +L + R Q G + C A
Sbjct: 45 QGRRALLRCEVEAPGPVHVYWLLDGAPVQDT-ERRFAQGSSLSFAAVDRLQDSGTFQCVA 103
Query: 111 ENGVGVPAIKSIRV--DVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFI 168
+ V +S ++++++ + + S+ + V LRC ++ +P +
Sbjct: 104 RDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAE--IQPQTQVTLRCHIDGHPRPTYQ 161
Query: 169 WKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKA 228
W R LS Q N + + L L+ P+ Y+C + G +
Sbjct: 162 WFRDGTPLSDGQSNHT-------VSSKERNLTLRPAGPEHSGLYSC--CAHSAFGQACSS 212
Query: 229 ITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQW----------SHG 278
F L+ A + + +VV E C + P P LQW
Sbjct: 213 QNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFS-AQPPPSLQWLFEDETPITNRSR 271
Query: 279 PGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITP 338
P L + G+L + V+ R++G Y C G P +L ++ A + P
Sbjct: 272 PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPI-----ILEATLHLAEIEDMP 326
Query: 339 DVIKESENIQLGQDLKLSC-HVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVT 397
+ E G + +++C +P+ V W+++ R+ V + E
Sbjct: 327 --LFEPRVFTAGSEERVTCLPPKGLPEPSV---WWEHA-GVRLPTHGRVYQKGHE----- 375
Query: 398 SSLELIDLHFSDYGTYLC-MASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREG 456
L L ++ SD G Y C A+ G D VNI+ TVP + P+ + EG
Sbjct: 376 --LVLANIAESDAGVYTCHAANLAGQRRQD----VNITVATVPSWLKKPQDS---QLEEG 426
Query: 457 SPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQT 516
P L C + P+P V+W R L+ E +G LR+ V YRC +
Sbjct: 427 KPGYLDCLTQATPKPTVVWYR---NQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMS 483
Query: 517 ARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW- 575
+ G QV ++F P +P + + CS + + + W
Sbjct: 484 STPAGSIEAQARVQVLEKLKFTPPPQPQQ---CMEFDKEATVPCS---ATGREKPTIKWE 537
Query: 576 RFKGQLLPPPPVVPAAAEAPDHA-ELRLDAVTRDSSGSYECSVSN 619
R G LP D+A L VTRD +G+Y C SN
Sbjct: 538 RADGSSLP--------EWVTDNAGTLHFARVTRDDAGNYTCIASN 574
Score = 59.7 bits (143), Expect = 1e-08
Identities = 97/432 (22%), Positives = 161/432 (37%), Gaps = 62/432 (14%)
Query: 57 MLQCLVTGHPRPQVRWTK------TAGSASDKFQETSVF-NETLRIERIARTQGGRYYCK 109
M C + P P ++W T S + +VF N +L + ++ G Y C
Sbjct: 243 MFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCI 302
Query: 110 AENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIW 169
+ G P I + + +++ L + F + C P +W
Sbjct: 303 GQGQRGPPIILEATLHLAEIEDMPLFEPRV-------FTAGSEERVTCLPPKGLPEPSVW 355
Query: 170 --KRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDK 227
G +H + +Y +G VL N+ D YTC + N+ G +
Sbjct: 356 WEHAGVRLPTHGR---------VYQKGHELVLA--NIAESDAGVYTCHAA--NLAG--QR 400
Query: 228 AITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGA- 286
+T T P LK + L G+ + CL T P P + W + +
Sbjct: 401 RQDVNITVATVPSWLKKPQDSQL--EEGKPGYLDCL-TQATPKPTVVWYRNQMLISEDSR 457
Query: 287 --LAQGGTLSIPSVQARDSGYYNCTATNNVGN-PAKKTVNLLVRSMKNATFQITPDVIKE 343
+ + GTL I SV+ D +Y C ++ G+ A+ V +L + + TP +
Sbjct: 458 FEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEK------LKFTPPP-QP 510
Query: 344 SENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELI 403
+ ++ ++ + C A +EK T +W + S VT N +L
Sbjct: 511 QQCMEFDKEATVPC--SATGREKPTIKW---ERADGSSLPEWVTDN-------AGTLHFA 558
Query: 404 DLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQC 463
+ D G Y C+AS P + V + TV I+ TV +G A LQC
Sbjct: 559 RVTRDDAGNYTCIAS--NGPQGQIRAHVQL---TVAVFITFKVEPERTTVYQGHTALLQC 613
Query: 464 EVRGKPRPPVLW 475
E +G P+P + W
Sbjct: 614 EAQGDPKPLIQW 625
Score = 43.9 bits (102), Expect = 7e-04
Identities = 63/259 (24%), Positives = 89/259 (34%), Gaps = 31/259 (11%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCK 109
+ EG L CL P+P V W + S+ + N TLRI + G Y C
Sbjct: 423 LEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCM 482
Query: 110 AENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIW 169
+ G +I++ + VQ L++ T F +E TV T P + W
Sbjct: 483 SSTPAG--SIEA-QARVQVLEKLKFTPPPQPQQCM-EFDKEATVPCSATGREKPTIK--W 536
Query: 170 KRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAI 229
+R + P + L + D +YTC S P I
Sbjct: 537 ERADGSSL-----------PEWVTDNAGTLHFARVTRDDAGNYTCIAS-----NGPQGQI 580
Query: 230 TFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQW--------SHGPGP 281
+ T A E V G +QC GDP P +QW S GPG
Sbjct: 581 RAHVQLTVAVFITFKVEPERTTVYQGHTALLQC-EAQGDPKPLIQWKDKPVPEESEGPGS 639
Query: 282 LPLGALAQGGTLSIPSVQA 300
P + Q LS+ + A
Sbjct: 640 PPPYKMIQTIGLSVGAAVA 658
Score = 30.8 bits (68), Expect = 6.3
Identities = 19/70 (27%), Positives = 31/70 (44%), Gaps = 9/70 (12%)
Query: 49 TIREGDTLMLQCLVTGHPRPQVRW------TKTAGSASD---KFQETSVFNETLRIERIA 99
T+ +G T +LQC G P+P ++W ++ G S K +T + + I
Sbjct: 602 TVYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYII 661
Query: 100 RTQGGRYYCK 109
G +YCK
Sbjct: 662 AVLGLMFYCK 671
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 102 bits (255), Expect = 1e-21
Identities = 154/699 (22%), Positives = 255/699 (36%), Gaps = 82/699 (11%)
Query: 56 LMLQCLVTGHPRPQVRWTKTAGSASD--KFQETSVFNETLRIERIARTQG-GRYYCKAEN 112
++L C G+P P RW K G+ D + +L I Q G Y C A N
Sbjct: 46 VILNCAANGYPSPHYRW-KQNGTDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATN 104
Query: 113 GVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARF----- 167
+G + ++ Y+++ TVS G + V L C PP F
Sbjct: 105 LLGTILSRKAKLQFAYIEDFETKTRSTVSVREG-----QGVVLLC----GPPPHFGDLSY 155
Query: 168 IWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQV----SVRNVCG 223
W + L +DN + ET L + + P D +YTC + + R+V G
Sbjct: 156 AWTFNDNPLYVQEDN------RRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQG 209
Query: 224 IPDKAITFRLTNTTA--PPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPG- 280
P + R P +++ ET+ +V ++C G+P+P + W G
Sbjct: 210 -PPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFAL-GNPVPDISWRRLDGS 267
Query: 281 PLP--LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITP 338
PLP + L IP+ Q D G+Y C A+N G K F P
Sbjct: 268 PLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAK---------GQLIFYAPP 318
Query: 339 DVIKESENIQLG--QDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAV 396
+ ++ +N L +L C P Y W KNG+ +R+ +
Sbjct: 319 EWEQKIQNTHLSIYDNLLWECKASGKPNP--WYTWLKNGERLNPEERIQIE--------- 367
Query: 397 TSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREG 456
+L + L+ SD G Y C A + + E+ + + + S K ++ V V G
Sbjct: 368 NGTLIITMLNVSDSGVYQCAAE-NKYQIIYANAELRVLASAPDFSKSPVKKKSFVQV--G 424
Query: 457 SPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQT 516
+ C+ PR + W R + LE DG L++ ++R +G+Y C
Sbjct: 425 GDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLE---DGSLKIYNITRSDAGSYTCIA 481
Query: 517 ARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWR 576
N F + + + V PS DV +G ++L C + P VW
Sbjct: 482 T--NQFGTAKNTGSLIVKERTVITVPPSKMDV--TVGESIVLPCQVSH-DPSIEVVFVWF 536
Query: 577 FKGQLLPPPPVVPAAAEAPDHA--ELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKA 634
F G ++ V + +L + + SG Y C+V + S + + + +
Sbjct: 537 FNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRG 596
Query: 635 YSPEFYFDTPNPTRSHKLSKNYSYVLQWTQRE-PDAVDPVLNYRLSIR-QLNQHNAVVKA 692
P P ++ S Q + R PD P+ + + R + V
Sbjct: 597 --------PPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQAVAT 648
Query: 693 IPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGD 731
+P + G+ + L YE R+ + G G+
Sbjct: 649 VP--EILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGE 685
Score = 72.8 bits (177), Expect = 1e-12
Identities = 91/403 (22%), Positives = 147/403 (36%), Gaps = 53/403 (13%)
Query: 55 TLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAEN-- 112
++ L+C G+P P + W + GS + S L I + G Y C A N
Sbjct: 244 SVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLR 303
Query: 113 GVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRG 172
G + + I ++ + H ++ D + C + P + W +
Sbjct: 304 GRNLAKGQLIFYAPPEWEQKIQNTHLSIYD---------NLLWECKASGKPNPWYTWLKN 354
Query: 173 SDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFR 232
+ L+ E + + T ++ + N+ D Y C + N I R
Sbjct: 355 GERLNPE--------ERIQIENGTLIITMLNV--SDSGVYQC--AAENKYQIIYANAELR 402
Query: 233 LTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGA---LAQ 289
+ +AP K V + V G ++ + C P + W G L L +
Sbjct: 403 VL-ASAPDFSKSPVKKKSFVQVGGDIVIGC-KPNAFPRAAISWKRGTETLRQSKRIFLLE 460
Query: 290 GGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQL 349
G+L I ++ D+G Y C ATN G AK T +L+V+ T V ++ +
Sbjct: 461 DGSLKIYNITRSDAGSYTCIATNQFGT-AKNTGSLIVKERTVIT------VPPSKMDVTV 513
Query: 350 GQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSD 409
G+ + L C V P +V + WF NG + K + + I LH S
Sbjct: 514 GESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHS- 572
Query: 410 YGTYLC---------------MASFPGAPVPDLSVEVNISSET 437
G YLC + P P D+ VE +ISS T
Sbjct: 573 -GKYLCTVQTTLESLSAVADIIVRGPPGPPEDVQVE-DISSTT 613
Score = 54.3 bits (129), Expect = 5e-07
Identities = 69/268 (25%), Positives = 103/268 (38%), Gaps = 34/268 (12%)
Query: 54 DTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENG 113
D L+ +C +G P P W K G + + + N TL I + + G Y C AEN
Sbjct: 333 DNLLWECKASGKPNPWYTWLKN-GERLNPEERIQIENGTLIITMLNVSDSGVYQCAAENK 391
Query: 114 VG-VPAIKSIRVDVQYLDEPMLTV-HQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKR 171
+ A +RV D V ++ V G+ + + C N+ P A WKR
Sbjct: 392 YQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGD------IVIGCKPNAFPRAAISWKR 445
Query: 172 GSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKA--- 228
G++TL S+ I+ L G LK+ N+ D SYTC + N G
Sbjct: 446 GTETLRQSK----RIF--LLEDGS---LKIYNITRSDAGSYTCIAT--NQFGTAKNTGSL 494
Query: 229 -ITFRLTNTTAPPALKLSVNETLVV------NPGENVTVQCLLTGGDPLPQLQWSHGPGP 281
+ R T P + ++V E++V+ +P V G + G
Sbjct: 495 IVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNG----DVIDLKKGVAH 550
Query: 282 LPLGALAQGGTLSIPSVQARDSGYYNCT 309
G L I ++Q SG Y CT
Sbjct: 551 FERIGGESVGDLMIRNIQLHHSGKYLCT 578
>gi|205277423 immunoglobulin superfamily, member 9 isoform b [Homo
sapiens]
Length = 1163
Score = 101 bits (252), Expect = 3e-21
Identities = 120/452 (26%), Positives = 187/452 (41%), Gaps = 65/452 (14%)
Query: 199 LKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTT--APPALKLSVNETLVVNPGE 256
L+++ LR +D Y C+V + D + T +PP + + L V E
Sbjct: 93 LQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELE 152
Query: 257 NVTVQCLLTGGDPLPQLQWSHGPGPLPLG---ALAQGGTLSIPSVQARDSGYYNCTATNN 313
VT++C+ G PLP + W L G Q GTL I V+ SG Y C A++
Sbjct: 153 PVTLRCVARGS-PLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASST 211
Query: 314 VGNPAKKTVNLLVRSMKNATFQITPDVI---KESENIQLGQDLKLSCHVDAVPQEKVTYQ 370
G+ T LLV + P VI ++ + QD+ L+CH +A P +TY
Sbjct: 212 EGSATHAT-QLLV---------LGPPVIVVPPKNSTVNASQDVSLACHAEAYPAN-LTYS 260
Query: 371 WFKNGKPARMSKRLLVTRNDPELPA-VTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSV 429
WF++ ++R P + V SL L+ D G Y C+ S
Sbjct: 261 WFQDNINV-----FHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPS----------- 304
Query: 430 EVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVL---WSRVDKEAALLP 486
+ PP+ S A +TV P ++C VR P P+L W++ D +A L
Sbjct: 305 ----NGLLHPPSAS-----AYLTVL-CMPGVIRCPVRANP--PLLFVSWTK-DGKALQLD 351
Query: 487 SGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE-VEPSS 545
+ +G L + + D G Y C YN ++ ++ PP +E
Sbjct: 352 KFPGWSQGTEGSLIIALGNEDALGEYSCTP--YNSLGTAGPSPVTRVLLKAPPAFIERPK 409
Query: 546 QDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAV 605
++ Q +GR +L+ CS +G P + S W G+ L A+ ++ L L +
Sbjct: 410 EEYFQEVGRELLIPCSA-QGDPPPVVS--WTKVGRGLQ------GQAQVDSNSSLILRPL 460
Query: 606 TRDSSGSYECSVSNDVGSAACLFQVSAKAYSP 637
T+++ G +ECS SN V A V SP
Sbjct: 461 TKEAHGHWECSASNAVARVATSTNVYVLGTSP 492
Score = 64.7 bits (156), Expect = 4e-10
Identities = 103/418 (24%), Positives = 161/418 (38%), Gaps = 67/418 (16%)
Query: 47 VYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRY 106
V ++E + + L+C+ G P P V W + V N TLRI R+ R G Y
Sbjct: 145 VLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVY 204
Query: 107 YCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPAR 166
C+A + G + + L P++ V S V + + V L C + P
Sbjct: 205 TCQASSTEG---SATHATQLLVLGPPVIVVPPKNSTVNAS----QDVSLACHAEAYP--- 254
Query: 167 FIWKRGSDTLSHSQDNGVDIYEPLYTQGETKV-----LKLKNLRPQDYASYTCQVSVRNV 221
+ T S QDN ++++ Q ++ L+L +P D YTC
Sbjct: 255 -----ANLTYSWFQDN-INVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTC------- 301
Query: 222 CGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGP 281
+P + PP+ S T++ PG ++C + PL + W+
Sbjct: 302 --VPSNGLLH-------PPS--ASAYLTVLCMPG---VIRCPVRANPPLLFVSWTKDGKA 347
Query: 282 LPLGAL---AQG--GTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQI 336
L L +QG G+L I G Y+CT N++G V ++ A +
Sbjct: 348 LQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIER 407
Query: 337 TPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAV 396
KE ++G++L + C P V+ W K G+ + + V N
Sbjct: 408 P----KEEYFQEVGRELLIPCSAQGDPPPVVS--WTKVGR--GLQGQAQVDSN------- 452
Query: 397 TSSLELIDLHFSDYGTYLCMASFPGAPV-PDLSVEVNISSETVPPTISV---PKGRAV 450
SSL L L +G + C AS A V +V V +S V +SV PKG V
Sbjct: 453 -SSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANV 509
Score = 63.9 bits (154), Expect = 7e-10
Identities = 66/242 (27%), Positives = 95/242 (39%), Gaps = 20/242 (8%)
Query: 398 SSLELIDLHFSDYGTYLCMASFPGAPVPDLSVE----VNISSETVPPTISVPKGRAVVTV 453
+SL++ L D G Y C F +P+ V+++ + P P AV+ V
Sbjct: 91 ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP--AVLEV 148
Query: 454 REGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYR 513
+E P L+C RG P P V W K+ L G + +G LR+ RV R SG Y
Sbjct: 149 QELEPVTLRCVARGSPLPHVTWKLRGKD---LGQGQGQVQVQNGTLRIRRVERGSSGVYT 205
Query: 514 CQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASA 573
CQ + G QL V PP + ++ + V L C P + +
Sbjct: 206 CQASSTEGSATH----ATQLLVLGPPVIVVPPKNSTVNASQDVSLACH-AEAYPANLTYS 260
Query: 574 VWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAK 633
++ + + P D LRL A D +G Y C SN + L SA
Sbjct: 261 WFQDNINVFHISRLQPRVRILVD-GSLRLLATQPDDAGCYTCVPSNGL-----LHPPSAS 314
Query: 634 AY 635
AY
Sbjct: 315 AY 316
Score = 43.1 bits (100), Expect = 0.001
Identities = 90/407 (22%), Positives = 140/407 (34%), Gaps = 77/407 (18%)
Query: 249 TLVVNPGENVTVQCLL---TGGDPLPQLQWSHGPGPLPLGA------------------L 287
++V GE+V + C L G PL ++W LP+ L
Sbjct: 28 SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRL 87
Query: 288 AQGGTLSIPSVQARDSGYYNCTA--------TNNVGNPAKKTVNLLVRSMKNATFQITPD 339
+G +L I ++ D G+Y C ++ N + V+L V S FQ TP
Sbjct: 88 QKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGS--WVHLTVNSPPQ--FQETPP 143
Query: 340 VIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSS 399
+ E + + + + L C P VT W GK + + +N +
Sbjct: 144 AVLEVQEL---EPVTLRCVARGSPLPHVT--WKLRGKDLGQGQGQVQVQN--------GT 190
Query: 400 LELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPA 459
L + + G Y C AS + + + PP I VP + TV
Sbjct: 191 LRIRRVERGSSGVYTCQASSTEGSATHATQLLVLG----PPVIVVPPKNS--TVNASQDV 244
Query: 460 ELQCEVRGKP-RPPVLWSRVDKEAALLPSGLP-LEETPDGKLRLERVSRDMSGTYRCQTA 517
L C P W + + + P + DG LRL D +G Y C +
Sbjct: 245 SLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPS 304
Query: 518 RYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRF 577
NG + P A L V L P ++RC + P S W
Sbjct: 305 --NGL-LHPPSASAYLTV----------------LCMPGVIRCPVRANPPLLFVS--WTK 343
Query: 578 KGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSA 624
G+ L P ++ + L + D+ G Y C+ N +G+A
Sbjct: 344 DGKALQLDK-FPGWSQGTE-GSLIIALGNEDALGEYSCTPYNSLGTA 388
>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
Length = 1174
Score = 99.4 bits (246), Expect = 1e-20
Identities = 93/376 (24%), Positives = 153/376 (40%), Gaps = 45/376 (11%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCK 109
+ G L+L+C+ +G P P + W K G + FN+ LRI ++ G Y+C
Sbjct: 269 VLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCL 328
Query: 110 AENGVG-VPAIKSIRVDV--QYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPAR 166
A N +G + S+RV +LDEP + D R L C N NP
Sbjct: 329 ASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGR----------LVCRANGNPKPT 378
Query: 167 FIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPD 226
W + L + N G+T + ++ + A Y C S + + +
Sbjct: 379 VQWMVNGEPLQSAPPN-----PNREVAGDTII--FRDTQISSRAVYQCNTSNEHGYLLAN 431
Query: 227 KAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQW-SHGPGPLPLG 285
++ PP + N+ + V + C G P+P L+W +G G G
Sbjct: 432 AFVSV----LDVPPRMLSPRNQLIRVILYNRTRLDCPFF-GSPIPTLRWFKNGQGSNLDG 486
Query: 286 A---LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIK 342
+ + G+L I ++ D G Y C ATN +G A+ V L V+ +++ D +
Sbjct: 487 GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK-AENQVRLEVKD-PTRIYRMPEDQV- 543
Query: 343 ESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLEL 402
+ G ++L C V P K+T W K+ +P + R+ + D SL +
Sbjct: 544 ----ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRM--KKED-------DSLTI 590
Query: 403 IDLHFSDYGTYLCMAS 418
+ D G+Y C+AS
Sbjct: 591 FGVAERDQGSYTCVAS 606
Score = 88.6 bits (218), Expect = 3e-17
Identities = 143/640 (22%), Positives = 232/640 (36%), Gaps = 111/640 (17%)
Query: 44 SERVYTIREGDTLMLQCLVTGHPRPQVRWTKTA---GSASDKFQETSVFNETLRIERIAR 100
S + + + D ++++C G+P P WT+ + A D + TL I+ R
Sbjct: 41 SAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVID--FR 98
Query: 101 TQG------GRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVF 154
+ G G Y C A N G IR+ V + L + + V + +
Sbjct: 99 SGGRPEEYEGEYQCFARNKFGTALSNRIRLQV---SKSPLWPKENLDPV--VVQEGAPLT 153
Query: 155 LRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQD-YASYT 213
L+C P+ I+ S +QD V +QG L N+ QD Y+
Sbjct: 154 LQCNPPPGLPSPVIFWMSSSMEPITQDKRV-------SQGHNGDLYFSNVMLQDMQTDYS 206
Query: 214 CQV---------------------------SVRN------VCGIPDKAITFRLTNTTAPP 240
C S+RN G+ ++ +F TA
Sbjct: 207 CNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASS 266
Query: 241 ALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALA---QGGTLSIPS 297
+ L G ++ ++C + G P P + W G LP L I +
Sbjct: 267 QMVLR---------GMDLLLEC-IASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITN 316
Query: 298 VQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQL--GQDLKL 355
V DSG Y C A+N +G+ + T+++ V++ P + E +N+ L G+D +L
Sbjct: 317 VSEEDSGEYFCLASNKMGS-IRHTISVRVKA--------APYWLDEPKNLILAPGEDGRL 367
Query: 356 SCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLC 415
C + P K T QW NG+P + + +P ++ D S Y C
Sbjct: 368 VCRANGNP--KPTVQWMVNGEPLQSAP------PNPNREVAGDTIIFRDTQISSRAVYQC 419
Query: 416 MASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLW 475
S L +S VPP + P+ + ++ V + L C G P P + W
Sbjct: 420 NTSNEHG---YLLANAFVSVLDVPPRMLSPRNQ-LIRVILYNRTRLDCPFFGSPIPTLRW 475
Query: 476 SRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNV 535
+ + + L + E +G L ++ + ++ G Y C G E QV+L V
Sbjct: 476 FKNGQGSNLDGGNYHVYE--NGSLEIKMIRKEDQGIYTCVATNILG----KAENQVRLEV 529
Query: 536 QFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAP 595
+ P + +D G V L C ++ P + W L P+
Sbjct: 530 KDPTRIYRMPEDQVARRGTTVQLECR-VKHDPSLKLTVSW-----LKDDEPLYIGNRMKK 583
Query: 596 DHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAY 635
+ L + V GSY C S + L Q AKAY
Sbjct: 584 EDDSLTIFGVAERDQGSYTCVASTE------LDQDLAKAY 617
Score = 55.8 bits (133), Expect = 2e-07
Identities = 96/429 (22%), Positives = 149/429 (34%), Gaps = 77/429 (17%)
Query: 237 TAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPL------GALAQG 290
T PP + + +V+P +N+ ++C G+P P W+ + +
Sbjct: 32 TQPPTITKQSAKDHIVDPRDNILIEC-EAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
Query: 291 GTLSIP----SVQARDSGYYNCTATNNVGNPAKKTVNLLV-RSMKNATFQITPDVIKESE 345
GTL I G Y C A N G + L V +S + P V++E
Sbjct: 91 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQE-- 148
Query: 346 NIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDL 405
G L L C+ V + + +P KR+ N DL
Sbjct: 149 ----GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNG-------------DL 191
Query: 406 HFSD------YGTYLCMASFPGAPV-------------------------PDLSVEVNIS 434
+FS+ Y C A F PD+ ++
Sbjct: 192 YFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVA 251
Query: 435 SETVPPTISVPKGRA-VVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEE 493
T P+ P+G A V G L+C G P P + W K+ LPS E
Sbjct: 252 ERT--PSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWY---KKGGDLPSDKAKFE 306
Query: 494 TPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALG 553
+ LR+ VS + SG Y C + G ++R + + V+ P +++ A G
Sbjct: 307 NFNKALRITNVSEEDSGEYFCLASNKMG-SIR---HTISVRVKAAPYWLDEPKNLILAPG 362
Query: 554 RPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSY 613
L C G+P+ + W G+ L P P A D R ++ S Y
Sbjct: 363 EDGRLVCR-ANGNPK--PTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQIS--SRAVY 417
Query: 614 ECSVSNDVG 622
+C+ SN+ G
Sbjct: 418 QCNTSNEHG 426
Score = 37.7 bits (86), Expect = 0.052
Identities = 62/264 (23%), Positives = 92/264 (34%), Gaps = 47/264 (17%)
Query: 411 GTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVR-GKP 469
G Y C A + + +S + P ++ V V+EG+P LQC G P
Sbjct: 108 GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP----VVVQEGAPLTLQCNPPPGLP 163
Query: 470 RPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVS-RDMSGTYRCQTARYNGFNVR--- 525
P + W E + + + +G L V +DM Y C + ++
Sbjct: 164 SPVIFWMSSSMEP--ITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKN 221
Query: 526 PREAQVQLNVQFP-------------------------PEVEPSSQDVRQALGRPVLLRC 560
P +V N + P+ SSQ V + G +LL C
Sbjct: 222 PFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLR--GMDLLLEC 279
Query: 561 SLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSND 620
+ G P W KG LP A + LR+ V+ + SG Y C SN
Sbjct: 280 -IASGVPT--PDIAWYKKGGDLPSDK----AKFENFNKALRITNVSEEDSGEYFCLASNK 332
Query: 621 VGSAACLFQVSAKAYSPEFYFDTP 644
+GS V KA ++ D P
Sbjct: 333 MGSIRHTISVRVKA--APYWLDEP 354
>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
Length = 1189
Score = 99.4 bits (246), Expect = 1e-20
Identities = 93/376 (24%), Positives = 153/376 (40%), Gaps = 45/376 (11%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCK 109
+ G L+L+C+ +G P P + W K G + FN+ LRI ++ G Y+C
Sbjct: 269 VLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCL 328
Query: 110 AENGVG-VPAIKSIRVDV--QYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPAR 166
A N +G + S+RV +LDEP + D R L C N NP
Sbjct: 329 ASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGR----------LVCRANGNPKPT 378
Query: 167 FIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPD 226
W + L + N G+T + ++ + A Y C S + + +
Sbjct: 379 VQWMVNGEPLQSAPPN-----PNREVAGDTII--FRDTQISSRAVYQCNTSNEHGYLLAN 431
Query: 227 KAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQW-SHGPGPLPLG 285
++ PP + N+ + V + C G P+P L+W +G G G
Sbjct: 432 AFVSV----LDVPPRMLSPRNQLIRVILYNRTRLDCPFF-GSPIPTLRWFKNGQGSNLDG 486
Query: 286 A---LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIK 342
+ + G+L I ++ D G Y C ATN +G A+ V L V+ +++ D +
Sbjct: 487 GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK-AENQVRLEVKD-PTRIYRMPEDQV- 543
Query: 343 ESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLEL 402
+ G ++L C V P K+T W K+ +P + R+ + D SL +
Sbjct: 544 ----ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRM--KKED-------DSLTI 590
Query: 403 IDLHFSDYGTYLCMAS 418
+ D G+Y C+AS
Sbjct: 591 FGVAERDQGSYTCVAS 606
Score = 88.6 bits (218), Expect = 3e-17
Identities = 143/640 (22%), Positives = 232/640 (36%), Gaps = 111/640 (17%)
Query: 44 SERVYTIREGDTLMLQCLVTGHPRPQVRWTKTA---GSASDKFQETSVFNETLRIERIAR 100
S + + + D ++++C G+P P WT+ + A D + TL I+ R
Sbjct: 41 SAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVID--FR 98
Query: 101 TQG------GRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVF 154
+ G G Y C A N G IR+ V + L + + V + +
Sbjct: 99 SGGRPEEYEGEYQCFARNKFGTALSNRIRLQV---SKSPLWPKENLDPV--VVQEGAPLT 153
Query: 155 LRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQD-YASYT 213
L+C P+ I+ S +QD V +QG L N+ QD Y+
Sbjct: 154 LQCNPPPGLPSPVIFWMSSSMEPITQDKRV-------SQGHNGDLYFSNVMLQDMQTDYS 206
Query: 214 CQV---------------------------SVRN------VCGIPDKAITFRLTNTTAPP 240
C S+RN G+ ++ +F TA
Sbjct: 207 CNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASS 266
Query: 241 ALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALA---QGGTLSIPS 297
+ L G ++ ++C + G P P + W G LP L I +
Sbjct: 267 QMVLR---------GMDLLLEC-IASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITN 316
Query: 298 VQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQL--GQDLKL 355
V DSG Y C A+N +G+ + T+++ V++ P + E +N+ L G+D +L
Sbjct: 317 VSEEDSGEYFCLASNKMGS-IRHTISVRVKA--------APYWLDEPKNLILAPGEDGRL 367
Query: 356 SCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLC 415
C + P K T QW NG+P + + +P ++ D S Y C
Sbjct: 368 VCRANGNP--KPTVQWMVNGEPLQSAP------PNPNREVAGDTIIFRDTQISSRAVYQC 419
Query: 416 MASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLW 475
S L +S VPP + P+ + ++ V + L C G P P + W
Sbjct: 420 NTSNEHG---YLLANAFVSVLDVPPRMLSPRNQ-LIRVILYNRTRLDCPFFGSPIPTLRW 475
Query: 476 SRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNV 535
+ + + L + E +G L ++ + ++ G Y C G E QV+L V
Sbjct: 476 FKNGQGSNLDGGNYHVYE--NGSLEIKMIRKEDQGIYTCVATNILG----KAENQVRLEV 529
Query: 536 QFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAP 595
+ P + +D G V L C ++ P + W L P+
Sbjct: 530 KDPTRIYRMPEDQVARRGTTVQLECR-VKHDPSLKLTVSW-----LKDDEPLYIGNRMKK 583
Query: 596 DHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAY 635
+ L + V GSY C S + L Q AKAY
Sbjct: 584 EDDSLTIFGVAERDQGSYTCVASTE------LDQDLAKAY 617
Score = 55.8 bits (133), Expect = 2e-07
Identities = 96/429 (22%), Positives = 149/429 (34%), Gaps = 77/429 (17%)
Query: 237 TAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPL------GALAQG 290
T PP + + +V+P +N+ ++C G+P P W+ + +
Sbjct: 32 TQPPTITKQSAKDHIVDPRDNILIEC-EAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
Query: 291 GTLSIP----SVQARDSGYYNCTATNNVGNPAKKTVNLLV-RSMKNATFQITPDVIKESE 345
GTL I G Y C A N G + L V +S + P V++E
Sbjct: 91 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQE-- 148
Query: 346 NIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDL 405
G L L C+ V + + +P KR+ N DL
Sbjct: 149 ----GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNG-------------DL 191
Query: 406 HFSD------YGTYLCMASFPGAPV-------------------------PDLSVEVNIS 434
+FS+ Y C A F PD+ ++
Sbjct: 192 YFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVA 251
Query: 435 SETVPPTISVPKGRA-VVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEE 493
T P+ P+G A V G L+C G P P + W K+ LPS E
Sbjct: 252 ERT--PSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWY---KKGGDLPSDKAKFE 306
Query: 494 TPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALG 553
+ LR+ VS + SG Y C + G ++R + + V+ P +++ A G
Sbjct: 307 NFNKALRITNVSEEDSGEYFCLASNKMG-SIR---HTISVRVKAAPYWLDEPKNLILAPG 362
Query: 554 RPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSY 613
L C G+P+ + W G+ L P P A D R ++ S Y
Sbjct: 363 EDGRLVCR-ANGNPK--PTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQIS--SRAVY 417
Query: 614 ECSVSNDVG 622
+C+ SN+ G
Sbjct: 418 QCNTSNEHG 426
Score = 37.7 bits (86), Expect = 0.052
Identities = 62/264 (23%), Positives = 92/264 (34%), Gaps = 47/264 (17%)
Query: 411 GTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVR-GKP 469
G Y C A + + +S + P ++ V V+EG+P LQC G P
Sbjct: 108 GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP----VVVQEGAPLTLQCNPPPGLP 163
Query: 470 RPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVS-RDMSGTYRCQTARYNGFNVR--- 525
P + W E + + + +G L V +DM Y C + ++
Sbjct: 164 SPVIFWMSSSMEP--ITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKN 221
Query: 526 PREAQVQLNVQFP-------------------------PEVEPSSQDVRQALGRPVLLRC 560
P +V N + P+ SSQ V + G +LL C
Sbjct: 222 PFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLR--GMDLLLEC 279
Query: 561 SLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSND 620
+ G P W KG LP A + LR+ V+ + SG Y C SN
Sbjct: 280 -IASGVPT--PDIAWYKKGGDLPSDK----AKFENFNKALRITNVSEEDSGEYFCLASNK 332
Query: 621 VGSAACLFQVSAKAYSPEFYFDTP 644
+GS V KA ++ D P
Sbjct: 333 MGSIRHTISVRVKA--APYWLDEP 354
>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
Length = 1169
Score = 99.4 bits (246), Expect = 1e-20
Identities = 93/376 (24%), Positives = 153/376 (40%), Gaps = 45/376 (11%)
Query: 50 IREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCK 109
+ G L+L+C+ +G P P + W K G + FN+ LRI ++ G Y+C
Sbjct: 269 VLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCL 328
Query: 110 AENGVG-VPAIKSIRVDV--QYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPAR 166
A N +G + S+RV +LDEP + D R L C N NP
Sbjct: 329 ASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGR----------LVCRANGNPKPT 378
Query: 167 FIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPD 226
W + L + N G+T + ++ + A Y C S + + +
Sbjct: 379 VQWMVNGEPLQSAPPN-----PNREVAGDTII--FRDTQISSRAVYQCNTSNEHGYLLAN 431
Query: 227 KAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQW-SHGPGPLPLG 285
++ PP + N+ + V + C G P+P L+W +G G G
Sbjct: 432 AFVSV----LDVPPRMLSPRNQLIRVILYNRTRLDCPFF-GSPIPTLRWFKNGQGSNLDG 486
Query: 286 A---LAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIK 342
+ + G+L I ++ D G Y C ATN +G A+ V L V+ +++ D +
Sbjct: 487 GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK-AENQVRLEVKD-PTRIYRMPEDQV- 543
Query: 343 ESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLEL 402
+ G ++L C V P K+T W K+ +P + R+ + D SL +
Sbjct: 544 ----ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRM--KKED-------DSLTI 590
Query: 403 IDLHFSDYGTYLCMAS 418
+ D G+Y C+AS
Sbjct: 591 FGVAERDQGSYTCVAS 606
Score = 88.6 bits (218), Expect = 3e-17
Identities = 143/640 (22%), Positives = 232/640 (36%), Gaps = 111/640 (17%)
Query: 44 SERVYTIREGDTLMLQCLVTGHPRPQVRWTKTA---GSASDKFQETSVFNETLRIERIAR 100
S + + + D ++++C G+P P WT+ + A D + TL I+ R
Sbjct: 41 SAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVID--FR 98
Query: 101 TQG------GRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVF 154
+ G G Y C A N G IR+ V + L + + V + +
Sbjct: 99 SGGRPEEYEGEYQCFARNKFGTALSNRIRLQV---SKSPLWPKENLDPV--VVQEGAPLT 153
Query: 155 LRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQD-YASYT 213
L+C P+ I+ S +QD V +QG L N+ QD Y+
Sbjct: 154 LQCNPPPGLPSPVIFWMSSSMEPITQDKRV-------SQGHNGDLYFSNVMLQDMQTDYS 206
Query: 214 CQV---------------------------SVRN------VCGIPDKAITFRLTNTTAPP 240
C S+RN G+ ++ +F TA
Sbjct: 207 CNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASS 266
Query: 241 ALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALA---QGGTLSIPS 297
+ L G ++ ++C + G P P + W G LP L I +
Sbjct: 267 QMVLR---------GMDLLLEC-IASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITN 316
Query: 298 VQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQL--GQDLKL 355
V DSG Y C A+N +G+ + T+++ V++ P + E +N+ L G+D +L
Sbjct: 317 VSEEDSGEYFCLASNKMGS-IRHTISVRVKA--------APYWLDEPKNLILAPGEDGRL 367
Query: 356 SCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLC 415
C + P K T QW NG+P + + +P ++ D S Y C
Sbjct: 368 VCRANGNP--KPTVQWMVNGEPLQSAP------PNPNREVAGDTIIFRDTQISSRAVYQC 419
Query: 416 MASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLW 475
S L +S VPP + P+ + ++ V + L C G P P + W
Sbjct: 420 NTSNEHG---YLLANAFVSVLDVPPRMLSPRNQ-LIRVILYNRTRLDCPFFGSPIPTLRW 475
Query: 476 SRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNV 535
+ + + L + E +G L ++ + ++ G Y C G E QV+L V
Sbjct: 476 FKNGQGSNLDGGNYHVYE--NGSLEIKMIRKEDQGIYTCVATNILG----KAENQVRLEV 529
Query: 536 QFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAP 595
+ P + +D G V L C ++ P + W L P+
Sbjct: 530 KDPTRIYRMPEDQVARRGTTVQLECR-VKHDPSLKLTVSW-----LKDDEPLYIGNRMKK 583
Query: 596 DHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAY 635
+ L + V GSY C S + L Q AKAY
Sbjct: 584 EDDSLTIFGVAERDQGSYTCVASTE------LDQDLAKAY 617
Score = 55.8 bits (133), Expect = 2e-07
Identities = 96/429 (22%), Positives = 149/429 (34%), Gaps = 77/429 (17%)
Query: 237 TAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPL------GALAQG 290
T PP + + +V+P +N+ ++C G+P P W+ + +
Sbjct: 32 TQPPTITKQSAKDHIVDPRDNILIEC-EAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
Query: 291 GTLSIP----SVQARDSGYYNCTATNNVGNPAKKTVNLLV-RSMKNATFQITPDVIKESE 345
GTL I G Y C A N G + L V +S + P V++E
Sbjct: 91 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQE-- 148
Query: 346 NIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDL 405
G L L C+ V + + +P KR+ N DL
Sbjct: 149 ----GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNG-------------DL 191
Query: 406 HFSD------YGTYLCMASFPGAPV-------------------------PDLSVEVNIS 434
+FS+ Y C A F PD+ ++
Sbjct: 192 YFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVA 251
Query: 435 SETVPPTISVPKGRA-VVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEE 493
T P+ P+G A V G L+C G P P + W K+ LPS E
Sbjct: 252 ERT--PSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWY---KKGGDLPSDKAKFE 306
Query: 494 TPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALG 553
+ LR+ VS + SG Y C + G ++R + + V+ P +++ A G
Sbjct: 307 NFNKALRITNVSEEDSGEYFCLASNKMG-SIR---HTISVRVKAAPYWLDEPKNLILAPG 362
Query: 554 RPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSY 613
L C G+P+ + W G+ L P P A D R ++ S Y
Sbjct: 363 EDGRLVCR-ANGNPK--PTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQIS--SRAVY 417
Query: 614 ECSVSNDVG 622
+C+ SN+ G
Sbjct: 418 QCNTSNEHG 426
Score = 37.7 bits (86), Expect = 0.052
Identities = 62/264 (23%), Positives = 92/264 (34%), Gaps = 47/264 (17%)
Query: 411 GTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVR-GKP 469
G Y C A + + +S + P ++ V V+EG+P LQC G P
Sbjct: 108 GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP----VVVQEGAPLTLQCNPPPGLP 163
Query: 470 RPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVS-RDMSGTYRCQTARYNGFNVR--- 525
P + W E + + + +G L V +DM Y C + ++
Sbjct: 164 SPVIFWMSSSMEP--ITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKN 221
Query: 526 PREAQVQLNVQFP-------------------------PEVEPSSQDVRQALGRPVLLRC 560
P +V N + P+ SSQ V + G +LL C
Sbjct: 222 PFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLR--GMDLLLEC 279
Query: 561 SLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSND 620
+ G P W KG LP A + LR+ V+ + SG Y C SN
Sbjct: 280 -IASGVPT--PDIAWYKKGGDLPSDK----AKFENFNKALRITNVSEEDSGEYFCLASNK 332
Query: 621 VGSAACLFQVSAKAYSPEFYFDTP 644
+GS V KA ++ D P
Sbjct: 333 MGSIRHTISVRVKA--APYWLDEP 354
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,100,258
Number of Sequences: 37866
Number of extensions: 2182578
Number of successful extensions: 12288
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 208
Number of HSP's successfully gapped in prelim test: 243
Number of HSP's that attempted gapping in prelim test: 6041
Number of HSP's gapped (non-prelim): 3452
length of query: 955
length of database: 18,247,518
effective HSP length: 112
effective length of query: 843
effective length of database: 14,006,526
effective search space: 11807501418
effective search space used: 11807501418
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.