Search of human proteins with 239758115

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239758115 PREDICTED: similar to complement factor H-related
1 isoform 2 [Homo sapiens]
         (271 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239758115 PREDICTED: similar to complement factor H-related 1...   586   e-168
gi|118442839 complement factor H-related 1 [Homo sapiens]             552   e-157
gi|239758113 PREDICTED: similar to complement factor H-related 1...   552   e-157
gi|5031695 H factor (complement)-like 3 [Homo sapiens]                505   e-143
gi|62739186 complement factor H isoform a precursor [Homo sapiens]    304   5e-83
gi|13540563 complement factor H-related 5 [Homo sapiens]              271   4e-73
gi|54792787 complement factor H-related 3 [Homo sapiens]              225   3e-59
gi|117320518 complement factor H-related 4 [Homo sapiens]             214   5e-56
gi|110611237 coagulation factor XIII B subunit precursor [Homo s...   148   4e-36
gi|62739188 complement factor H isoform b precursor [Homo sapiens]    130   2e-30
gi|42544177 complement component (3d/Epstein Barr virus) recepto...    74   1e-13
gi|54792123 complement component (3d/Epstein Barr virus) recepto...    74   1e-13
gi|4502503 complement component 4 binding protein, alpha chain p...    72   5e-13
gi|153266841 apolipoprotein H precursor [Homo sapiens]                 66   4e-11
gi|148886654 polydom [Homo sapiens]                                    65   6e-11
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi...    64   1e-10
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi...    64   1e-10
gi|168693643 decay accelerating factor for complement isoform 2 ...    60   2e-09
gi|10835143 decay accelerating factor for complement isoform 1 p...    60   2e-09
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap...    59   6e-09
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa...    59   6e-09
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap...    59   6e-09
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]           56   3e-08
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ...    55   5e-08
gi|62912468 complement component 4 binding protein, beta chain i...    54   2e-07
gi|62912466 complement component 4 binding protein, beta chain i...    54   2e-07
gi|62912464 complement component 4 binding protein, beta chain i...    54   2e-07
gi|62912462 complement component 4 binding protein, beta chain i...    54   2e-07
gi|4502505 complement component 4 binding protein, beta chain is...    54   2e-07
gi|27502421 CD46 antigen, complement regulatory protein isoform ...    51   1e-06

>gi|239758115 PREDICTED: similar to complement factor H-related 1
           isoform 2 [Homo sapiens]
          Length = 271

 Score =  586 bits (1510), Expect = e-168
 Identities = 271/271 (100%), Positives = 271/271 (100%)

Query: 1   MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
           MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
Sbjct: 1   MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60

Query: 61  SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
           SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
Sbjct: 61  SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120

Query: 121 QNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 180
           QNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 180

Query: 181 LYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFV 240
           LYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFV
Sbjct: 181 LYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFV 240

Query: 241 CKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 271
           CKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
Sbjct: 241 CKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 271


>gi|118442839 complement factor H-related 1 [Homo sapiens]
          Length = 330

 Score =  552 bits (1423), Expect = e-157
 Identities = 270/330 (81%), Positives = 270/330 (81%), Gaps = 59/330 (17%)

Query: 1   MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
           MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
Sbjct: 1   MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60

Query: 61  SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
           SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
Sbjct: 61  SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120

Query: 121 QNNENNISCVERGWSTPPK------------------------------------CRST- 143
           QNNENNISCVERGWSTPPK                                    CRS  
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180

Query: 144 ----------------------DSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 181
                                 DSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL
Sbjct: 181 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 240

Query: 182 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC 241
           YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC
Sbjct: 241 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC 300

Query: 242 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 271
           KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
Sbjct: 301 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 330


>gi|239758113 PREDICTED: similar to complement factor H-related 1
           isoform 1 [Homo sapiens]
          Length = 330

 Score =  552 bits (1423), Expect = e-157
 Identities = 270/330 (81%), Positives = 270/330 (81%), Gaps = 59/330 (17%)

Query: 1   MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
           MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
Sbjct: 1   MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60

Query: 61  SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
           SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
Sbjct: 61  SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120

Query: 121 QNNENNISCVERGWSTPPK------------------------------------CRST- 143
           QNNENNISCVERGWSTPPK                                    CRS  
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180

Query: 144 ----------------------DSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 181
                                 DSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL
Sbjct: 181 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 240

Query: 182 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC 241
           YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC
Sbjct: 241 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC 300

Query: 242 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 271
           KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
Sbjct: 301 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 330


>gi|5031695 H factor (complement)-like 3 [Homo sapiens]
          Length = 270

 Score =  505 bits (1300), Expect = e-143
 Identities = 234/271 (86%), Positives = 246/271 (90%), Gaps = 1/271 (0%)

Query: 1   MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
           MWLLVSVILISRISSVGGEA FCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
Sbjct: 1   MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60

Query: 61  SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
           SPSKSFWTRITC EEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
Sbjct: 61  SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120

Query: 121 QNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 180
           QNNENNISCVERGWSTPPKCRST S  KCGPPPPIDNGDITSF LSVYAP SSVEYQCQN
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN 180

Query: 181 LYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFV 240
           LYQLEGN +ITCRNGQWSEPPKCL PCVIS+EIME YNI L+WT +QKLY RTG+  EFV
Sbjct: 181 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV 240

Query: 241 CKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 271
           CK GY   ++SH+ R  C +GKL YP+C ++
Sbjct: 241 CKSGYH-PTKSHSFRAMCQNGKLVYPSCEEK 270


>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  304 bits (779), Expect = 5e-83
 Identities = 150/227 (66%), Positives = 168/227 (74%), Gaps = 9/227 (3%)

Query: 48   GEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFF--PFVENGHSESSGQT-H 104
            GE   Y+C   +     S    +TC    W+  P C        P V+N +  S   + +
Sbjct: 1011 GEQVTYTCATYYKMDGAS---NVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKY 1067

Query: 105  LEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFP 164
              G+ V+  C + Y +  +E  + C+   W+ PP+C+  DSTGKCGPPPPIDNGDITSFP
Sbjct: 1068 PSGERVRYQCRSPYEMFGDEE-VMCLNGNWTEPPQCK--DSTGKCGPPPPIDNGDITSFP 1124

Query: 165  LSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWT 224
            LSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWT
Sbjct: 1125 LSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWT 1184

Query: 225  AKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 271
            AKQKLY RTGES EFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
Sbjct: 1185 AKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 1231



 Score =  158 bits (400), Expect = 4e-39
 Identities = 81/253 (32%), Positives = 132/253 (52%), Gaps = 14/253 (5%)

Query: 23  CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
           CD+P I HG LY E   +P+  V  G+ + Y C+ +F +PS S+W  I CT++GWSP   
Sbjct: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384

Query: 83  CLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRS 142
           CLR C+FP++ENG++++ G+  ++G ++ + C+ GY L   +  ++C+E GWS  P+C  
Sbjct: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIR 444

Query: 143 TDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQL---EGNKRITCRNGQWSE 199
             +  K      I+NG I+    + YA     +YQC+  Y     E +  ITC    WS 
Sbjct: 445 VKTCSKSS--IDIENGFISESQYT-YALKEKAKYQCKLGYVTADGETSGSITCGKDGWSA 501

Query: 200 PPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTC- 258
            P C+  C I   +  N       T     + +  ++ ++ C  GY  ++ S T    C 
Sbjct: 502 QPTCIKSCDI--PVFMNAR-----TKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCG 554

Query: 259 WDGKLEYPTCAKR 271
           ++G  + P C +R
Sbjct: 555 YNGWSDLPICYER 567



 Score = 77.8 bits (190), Expect = 9e-15
 Identities = 57/192 (29%), Positives = 93/192 (48%), Gaps = 25/192 (13%)

Query: 23  CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNF--VSPSKSFWTRITCTEEGWSPT 80
           C+ PKI+  ++ D +K     Q   GEV  +SC+  F  V P+      + C   G SP 
Sbjct: 569 CELPKIDVHLVPDRKK----DQYKVGEVLKFSCKPGFTIVGPNS-----VQCYHFGLSPD 619

Query: 81  -PKC---LRLCFFP--FVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
            P C   ++ C  P   +     E + + +   + V+  CN  + L    N I CV+  W
Sbjct: 620 LPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRF-LMKGPNKIQCVDGEW 678

Query: 135 STPPKCRSTDSTGKCGPPPPIDNG--DITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC 192
           +T P C   +ST  CG  P +++G   ++S P   Y    SVE+ C   + + G++ ITC
Sbjct: 679 TTLPVCIVEEST--CGDIPELEHGWAQLSSPP---YYYGDSVEFNCSESFTMIGHRSITC 733

Query: 193 RNGQWSEPPKCL 204
            +G W++ P+C+
Sbjct: 734 IHGVWTQLPQCV 745



 Score = 75.9 bits (185), Expect = 4e-14
 Identities = 60/250 (24%), Positives = 98/250 (39%), Gaps = 18/250 (7%)

Query: 23  CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
           CD P     +  +      F+     +   Y C   + S + S    I C   GWS  P 
Sbjct: 509 CDIP-----VFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI 563

Query: 83  CL-RLCFFPFVE-NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PK 139
           C  R C  P ++ +   +     +  G+ ++  C  G+ +    N++ C   G S   P 
Sbjct: 564 CYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVG-PNSVQCYHFGLSPDLPI 622

Query: 140 CRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSE 199
           C+  +    CGPPP + NG++       Y  +  VEY C   + ++G  +I C +G+W+ 
Sbjct: 623 CK--EQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTT 680

Query: 200 PPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGY-RLSSRSHTLRTTC 258
            P C+       +I E   +   W          G+S EF C   +  +  RS T     
Sbjct: 681 LPVCIVEESTCGDIPE---LEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGV 737

Query: 259 WDGKLEYPTC 268
           W    + P C
Sbjct: 738 W---TQLPQC 744



 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 60/246 (24%), Positives = 94/246 (38%), Gaps = 20/246 (8%)

Query: 26   PKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLR 85
            P+I HG +      +       G    Y+CE  F    ++     TC    WS  P+C  
Sbjct: 874  PQIEHGTINSSRSSQ--ESYAHGTKLSYTCEGGFRISEEN---ETTCYMGKWSSPPQCEG 928

Query: 86   L-CFFP-FVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRST 143
            L C  P  + +G       ++  G+ V   C  G+ + +      C+   WS PP C  T
Sbjct: 929  LPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGI-DGPAIAKCLGEKWSHPPSCIKT 987

Query: 144  DSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKC 203
            D    C   P  +N         VY     V Y C   Y+++G   +TC N +W+  P C
Sbjct: 988  D----CLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTC 1043

Query: 204  LHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGK- 262
                 ++   ++N  I  R  +K      +GE   + C+  Y +      +   C +G  
Sbjct: 1044 RDTSCVNPPTVQNAYIVSRQMSKYP----SGERVRYQCRSPYEMFGDEEVM---CLNGNW 1096

Query: 263  LEYPTC 268
             E P C
Sbjct: 1097 TEPPQC 1102



 Score = 69.3 bits (168), Expect = 3e-12
 Identities = 62/254 (24%), Positives = 98/254 (38%), Gaps = 24/254 (9%)

Query: 19  EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWT----RITCTE 74
           E+T  D P++ HG       +   S  P    +YY     F + S+SF       ITC  
Sbjct: 688 ESTCGDIPELEHG-------WAQLSSPP----YYYGDSVEF-NCSESFTMIGHRSITCIH 735

Query: 75  EGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNIS--CVER 132
             W+  P+C+ +      ++ +     +            N  YR +  E  I   C+  
Sbjct: 736 GVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCING 795

Query: 133 GWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC 192
            W     C S      C PPP I N    +  L+ Y     V   CQ  Y ++  + ITC
Sbjct: 796 RWDPEVNC-SMAQIQLCPPPPQIPNSHNMTTTLN-YRDGEKVSVLCQENYLIQEGEEITC 853

Query: 193 RNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSH 252
           ++G+W   P C+     S+     +       + Q+ Y   G    + C+ G+R+S  + 
Sbjct: 854 KDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAH-GTKLSYTCEGGFRISEEN- 911

Query: 253 TLRTTCWDGKLEYP 266
              TTC+ GK   P
Sbjct: 912 --ETTCYMGKWSSP 923



 Score = 64.7 bits (156), Expect = 8e-11
 Identities = 57/233 (24%), Positives = 79/233 (33%), Gaps = 30/233 (12%)

Query: 49  EVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL-RLCFFPFVENGHSESSGQTHLEG 107
           E F Y C   +    +       CTE GW P P C  + C  P++ NG        H  G
Sbjct: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287

Query: 108 DTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDI------- 160
           D +   C  G+      N   C   GW   P+C     T K    P I +G +       
Sbjct: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC-----TLKPCDYPDIKHGGLYHENMRR 342

Query: 161 TSFPLSVYAPASSVEYQCQNLYQLEGNK---RITCRNGQWSEPPKCLHPCVISREIMENY 217
             FP++V        Y C   ++         I C    WS    CL  C      +EN 
Sbjct: 343 PYFPVAV---GKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYF--PYLEN- 396

Query: 218 NIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAK 270
                +          G+S +  C  GY L  ++ T  T   +G    P C +
Sbjct: 397 ----GYNQNHGRKFVQGKSIDVACHPGYAL-PKAQTTVTCMENGWSPTPRCIR 444



 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 47/164 (28%), Positives = 72/164 (43%), Gaps = 18/164 (10%)

Query: 114 CNTGYRLQNNENNISCVERGWSTP-PKCRSTDSTGKCGPPPPIDNGDITSF---PLSVYA 169
           CN GY+L    N   C   GW+   P C       KC P    +NG I S    P   Y 
Sbjct: 114 CNEGYQLLGEINYRECDTDGWTNDIPICEVV----KCLPVTAPENGKIVSSAMEPDREYH 169

Query: 170 PASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPCVISREIMENYNIALRWTAKQ 227
              +V + C + Y++EG++ + C  +G WS E PKC+     S +++    I+      Q
Sbjct: 170 FGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS------Q 223

Query: 228 KLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 271
           K+  +  E  ++ C  GY  S R   + T    G    P+C ++
Sbjct: 224 KIIYKENERFQYKCNMGYEYSERGDAVCTE--SGWRPLPSCEEK 265



 Score = 55.1 bits (131), Expect = 6e-08
 Identities = 50/206 (24%), Positives = 84/206 (40%), Gaps = 23/206 (11%)

Query: 72  CTEEGWS-PTPKCLRLCFFPFV--ENGHSESSG----QTHLEGDTVQIICNTGYRLQNNE 124
           C  +GW+   P C  +   P    ENG   SS     + +  G  V+ +CN+GY+++ +E
Sbjct: 129 CDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE 188

Query: 125 NNISCVERG-WS-TPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLY 182
             + C + G WS   PKC        C  P  I+   I+     +Y      +Y+C   Y
Sbjct: 189 -EMHCSDDGFWSKEKPKCVEI----SCKSPDVINGSPISQ--KIIYKENERFQYKCNMGY 241

Query: 183 QLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCK 242
           +        C    W   P C        +  +N  I     +  ++  RTG+   + C+
Sbjct: 242 EYSERGDAVCTESGWRPLPSC------EEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCR 295

Query: 243 RGYRLSSRSHTLRTTCWDGKLEYPTC 268
            G+  ++R +T + T   G +  P C
Sbjct: 296 NGFYPATRGNTAKCTS-TGWIPAPRC 320



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 40/150 (26%), Positives = 54/150 (36%), Gaps = 5/150 (3%)

Query: 100 SGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGD 159
           S QT+ EG      C  GYR   N   + C +  W      R       CG P     G 
Sbjct: 38  SDQTYPEGTQAIYKCRPGYRSLGNVIMV-CRKGEWVALNPLRKCQKR-PCGHPGDTPFGT 95

Query: 160 ITSFPLSVYAPASSVEYQCQNLYQLEG--NKRITCRNGQWSEPPKCLHPCVISREIMENY 217
            T    +V+       Y C   YQL G  N R    +G  ++ P C     +     EN 
Sbjct: 96  FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENG 155

Query: 218 NIALRWTAKQKLYLRTGESAEFVCKRGYRL 247
            I        + Y   G++  FVC  GY++
Sbjct: 156 KIVSSAMEPDREY-HFGQAVRFVCNSGYKI 184



 Score = 31.2 bits (69), Expect = 1.0
 Identities = 16/51 (31%), Positives = 24/51 (47%), Gaps = 2/51 (3%)

Query: 149 CGPPPPIDNGDIT--SFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQW 197
           C   PP  N +I   S+    Y   +   Y+C+  Y+  GN  + CR G+W
Sbjct: 21  CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71


>gi|13540563 complement factor H-related 5 [Homo sapiens]
          Length = 569

 Score =  271 bits (693), Expect = 4e-73
 Identities = 134/198 (67%), Positives = 146/198 (73%), Gaps = 3/198 (1%)

Query: 1   MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
           M LL SVILIS +S+VGGE T CDFPKI+HG LYDEE Y PFSQVPTGEVFYYSCEYNFV
Sbjct: 1   MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV 60

Query: 61  SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
           SPSKSFWTRITCTEEGWSPTPKCLR+C FPFV+NGHSESSG  HLEGDTVQIICNTGY L
Sbjct: 61  SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL 120

Query: 121 QNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 180
           QNNE NISCVERGWSTPP C  T   G+C  P    N D      S Y     +++ C+ 
Sbjct: 121 QNNEKNISCVERGWSTPPICSFT--KGECHVPILEANVDAQPKKES-YKVGDVLKFSCRK 177

Query: 181 LYQLEGNKRITCRNGQWS 198
                G+  + C    WS
Sbjct: 178 NLIRVGSDSVQCYQFGWS 195



 Score =  177 bits (448), Expect = 1e-44
 Identities = 86/201 (42%), Positives = 119/201 (59%), Gaps = 13/201 (6%)

Query: 70  ITCTE--EGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNI 127
           + CTE  E + P P        P + N  + ++   + +G+ V ++C   Y L   +  I
Sbjct: 379 VDCTEKREQFCPPP--------PQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKE-I 429

Query: 128 SCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGN 187
            C +  W + P+C   +ST  CGPPP I+NGD TSFPLSVY P S+V Y+CQ+ Y+L+G+
Sbjct: 430 VCKDGRWQSLPRC--VESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGS 487

Query: 188 KRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 247
             +TCRN QWSEPP+CL PCV+S E M   NI L+W    KLY +TG++ EF CK  ++ 
Sbjct: 488 VTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKA 547

Query: 248 SSRSHTLRTTCWDGKLEYPTC 268
              S   R  C +GK EYP C
Sbjct: 548 MISSPPFRAICQEGKFEYPIC 568



 Score = 77.8 bits (190), Expect = 9e-15
 Identities = 65/233 (27%), Positives = 98/233 (42%), Gaps = 26/233 (11%)

Query: 36  EEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPT-PKC---LRLCFFP- 90
           +E YK       G+V  +SC  N +         + C + GWSP  P C   +R C  P 
Sbjct: 162 KESYK------VGDVLKFSCRKNLIRVGSD---SVQCYQFGWSPNFPTCKGQVRSCGPPP 212

Query: 91  FVENGH-SESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKC 149
            + NG   E   + +   + V+  CN  + + N    I CV+  W+T P C   +    C
Sbjct: 213 QLSNGEVKEIRKEEYGHNEVVEYDCNPNFII-NGPKKIQCVDGEWTTLPTC--VEQVKTC 269

Query: 150 GPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVI 209
           G  P ++ G +    +  Y    SVE  C+N Y + GN  ITC NG W+E P C+    +
Sbjct: 270 GYIPELEYGYVQP-SVPPYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQL 328

Query: 210 SREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGK 262
            R  +   NI       + L   +G+      +  YR S       + C +GK
Sbjct: 329 KRCKIAGVNI-------KTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGK 374



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 41/144 (28%), Positives = 61/144 (42%), Gaps = 14/144 (9%)

Query: 127 ISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEG 186
           I+C E GWS  PKC    S       P + NG   S  L ++    +V+  C   Y L+ 
Sbjct: 70  ITCTEEGWSPTPKCLRMCSF------PFVKNGHSESSGL-IHLEGDTVQIICNTGYSLQN 122

Query: 187 N-KRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRG- 244
           N K I+C    WS PP C          +   N+  +   K++ Y + G+  +F C++  
Sbjct: 123 NEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQ--PKKESY-KVGDVLKFSCRKNL 179

Query: 245 YRLSSRSHTLRTTCWDGKLEYPTC 268
            R+ S S       W     +PTC
Sbjct: 180 IRVGSDSVQCYQFGWSP--NFPTC 201



 Score = 33.5 bits (75), Expect = 0.20
 Identities = 19/66 (28%), Positives = 29/66 (43%), Gaps = 7/66 (10%)

Query: 189 RITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLS 248
           RITC    WS  PKCL  C  S   ++N +     +    L    G++ + +C  GY L 
Sbjct: 69  RITCTEEGWSPTPKCLRMC--SFPFVKNGH-----SESSGLIHLEGDTVQIICNTGYSLQ 121

Query: 249 SRSHTL 254
           +    +
Sbjct: 122 NNEKNI 127


>gi|54792787 complement factor H-related 3 [Homo sapiens]
          Length = 330

 Score =  225 bits (574), Expect = 3e-59
 Identities = 116/331 (35%), Positives = 171/331 (51%), Gaps = 65/331 (19%)

Query: 1   MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCE---- 56
           M LL++VIL   +S   G+   CDFP I HG L+ E   +P+  V  G+ + Y C+    
Sbjct: 1   MLLLINVILTLWVSCANGQVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFE 60

Query: 57  ------YNFVSPSKSFW------------------------------------------- 67
                 ++++  +++ W                                           
Sbjct: 61  TPSGSYWDYIHCTQNGWSPAVPCLRKCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGL 120

Query: 68  ----TRITCTEEGWSPTPKCLRLCFFPF----VENGHSESSGQTHLEGDTVQIICNTGYR 119
               T +TCTE+GWSPTP+C+R+         +ENG    S   ++    +Q  C  GY 
Sbjct: 121 PKAQTTVTCTEKGWSPTPRCIRVRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYA 180

Query: 120 LQ--NNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQ 177
               N+  +I+C++ GWS  P C   +S+ KCGPPPPI NGD TSF L VY P S VEYQ
Sbjct: 181 TADGNSSGSITCLQNGWSAQPIC--INSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQ 238

Query: 178 CQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESA 237
           CQ  Y+L+G+  +TC NG+WSEPP+C+HPC+I+ E M   NI L+  + +K Y +TG++ 
Sbjct: 239 CQPYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTI 298

Query: 238 EFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 268
           EF+CK GY  ++   + +  C +G +EYP C
Sbjct: 299 EFMCKLGYNANTSILSFQAVCREGIVEYPRC 329


>gi|117320518 complement factor H-related 4 [Homo sapiens]
          Length = 331

 Score =  214 bits (546), Expect = 5e-56
 Identities = 118/332 (35%), Positives = 163/332 (49%), Gaps = 66/332 (19%)

Query: 1   MWLLVSVILISRISSVGG-EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYN- 58
           M LL++VIL   +S   G E   CDFP+I HG LY +   + +     G+ + Y C+ N 
Sbjct: 1   MLLLINVILTLWVSCANGQEVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNF 60

Query: 59  --------------------------------------FVSPSKSFWT------------ 68
                                                 F+S S S +             
Sbjct: 61  VTPSGSYWDYIHCTQDGWSPTVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPG 120

Query: 69  ----------RITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGY 118
                      ITC + GWS  P C++ C  P  EN  ++S+G      DT+   C  GY
Sbjct: 121 YATADGNSSGSITCLQNGWSAQPICIKFCDMPVFENSRAKSNGMRFKLHDTLDYECYDGY 180

Query: 119 RLQ--NNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEY 176
            +   N   +I C E GWS  P C +  S+ KCGPPPPI NGD TSF L VY P S VEY
Sbjct: 181 EISYGNTTGSIVCGEDGWSHFPTCYN--SSEKCGPPPPISNGDTTSFLLKVYVPQSRVEY 238

Query: 177 QCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGES 236
           QCQ+ Y+L+G+  +TC NG+WSEPP+C+HPC+I+ E M   NI L+  +  K Y +TG++
Sbjct: 239 QCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKTGDT 298

Query: 237 AEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 268
            EF+CK GY  ++   + +  C +G +EYP C
Sbjct: 299 IEFMCKLGYNANTSVLSFQAVCREGIVEYPRC 330


>gi|110611237 coagulation factor XIII B subunit precursor [Homo
           sapiens]
          Length = 661

 Score =  148 bits (374), Expect = 4e-36
 Identities = 80/232 (34%), Positives = 119/232 (51%), Gaps = 16/232 (6%)

Query: 48  GEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLR-----LCFFP-FVENGHSESSG 101
           GE+ +  CE NF     +    I C +  W+  PKC+       C  P F+ENG +    
Sbjct: 295 GEIVHIECELNFEIHGSA---EIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHS 351

Query: 102 QTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDIT 161
           + +  GD V   C +GY L  + N I+C    W+ PP+C   ++   C  PP + NG + 
Sbjct: 352 KIYYNGDKVTYACKSGYLLHGS-NEITCNRGKWTLPPEC--VENNENCKHPPVVMNGAVA 408

Query: 162 SFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIAL 221
              L+ YA  SSVEY+C   Y L G+K   C  G+WS PP CL PC ++ + M   NI +
Sbjct: 409 DGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEM 468

Query: 222 RWTAKQKLYLRTGESAEFVCKRGYRLSSRS--HTLRTTCWDGKLEYPTCAKR 271
           +W  + K+    G+  +FVCK+GY LS  +    L   C  G+++YP C ++
Sbjct: 469 KWKYEGKVL--HGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRK 518



 Score =  120 bits (302), Expect = 1e-27
 Identities = 78/238 (32%), Positives = 109/238 (45%), Gaps = 18/238 (7%)

Query: 47  TGEVFYYSC-EYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFF--PFVENGHSESSGQT 103
           TG    Y C EY  +  SK       C +  WS  P CL  C     ++   + E   + 
Sbjct: 417 TGSSVEYRCNEYYLLRGSKIS----RCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKY 472

Query: 104 H---LEGDTVQIICNTGYRLQN----NENNISCVERGWSTPPKCRSTDSTGKCGPPPPID 156
               L GD +  +C  GY L      +E ++ C  RG    P C   +S G C  PP I 
Sbjct: 473 EGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQC-NRGEVKYPLCTRKESKGMCTSPPLIK 531

Query: 157 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMEN 216
           +G I S  +  Y   SSVEY+C + + LEG++   C +G W+ PP CL PC +S   ME 
Sbjct: 532 HGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEK 591

Query: 217 YNIALRWTAKQKLYLRTGESAEFVCKRG---YRLSSRSHTLRTTCWDGKLEYPTCAKR 271
            N+ L+W    + ++  GE  EF+C+       L      LR  C  G+L+YP C  R
Sbjct: 592 NNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPR 649



 Score = 95.1 bits (235), Expect = 6e-20
 Identities = 67/221 (30%), Positives = 96/221 (43%), Gaps = 19/221 (8%)

Query: 53  YSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRL--CFFPFVENGHSESSGQTHLEGDTV 110
           Y C   + +        + C   GWS TPKC +L       +ENG+     QT+ EGD V
Sbjct: 178 YECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVV 237

Query: 111 QIICNTGYRLQNNENNISCVERGW-STPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYA 169
           Q  C+  Y L  ++  I C   GW    P C    +  +C PPP   N  I +   + Y 
Sbjct: 238 QFFCHENYYLSGSDL-IQCYNFGWYPESPVCEGRRN--RCPPPPLPINSKIQTHS-TTYR 293

Query: 170 PASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCL--HPCVISRE--IMENYNIALRWTA 225
               V  +C+  +++ G+  I C +G+W+EPPKC+     V   E   +EN    L    
Sbjct: 294 HGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLH--- 350

Query: 226 KQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYP 266
             K+Y   G+   + CK GY L   +     TC  GK   P
Sbjct: 351 -SKIYY-NGDKVTYACKSGYLLHGSN---EITCNRGKWTLP 386



 Score = 87.8 bits (216), Expect = 9e-18
 Identities = 71/266 (26%), Positives = 109/266 (40%), Gaps = 36/266 (13%)

Query: 31  GILYDEEKYKPFSQVPTGEV--FYYS-----------------CEYNFVSPSKSFWTRIT 71
           G LY EEK   F  V  G +  +YY+                 C   + + S     + T
Sbjct: 16  GELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTT 75

Query: 72  CTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQ--NNENNISC 129
           CT EGWSP P+C + C  P + NG+       +   + ++  C +GY+     +E  + C
Sbjct: 76  CTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQC 135

Query: 130 VERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKR 189
           +  GWS+ P CR    T      P + NG+  S     +     V+Y+C   Y   G K+
Sbjct: 136 LSDGWSSQPTCRKEHETCLA---PELYNGNY-STTQKTFKVKDKVQYECATGYYTAGGKK 191

Query: 190 ---ITCRNGQWSEPPKCLHPCVISREIMEN-YNIALRWTAKQKLYLRTGESAEFVCKRGY 245
              + C    WS  PKC      S  ++EN Y   ++ T ++      G+  +F C   Y
Sbjct: 192 TEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEE------GDVVQFFCHENY 245

Query: 246 RLSSRSHTLRTTCWDGKLEYPTCAKR 271
            LS  S  ++   +    E P C  R
Sbjct: 246 YLSG-SDLIQCYNFGWYPESPVCEGR 270


>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
          Length = 449

 Score =  130 bits (326), Expect = 2e-30
 Identities = 48/118 (40%), Positives = 78/118 (66%)

Query: 23  CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
           CD+P I HG LY E   +P+  V  G+ + Y C+ +F +PS S+W  I CT++GWSP   
Sbjct: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384

Query: 83  CLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKC 140
           CLR C+FP++ENG++++ G+  ++G ++ + C+ GY L   +  ++C+E GWS  P+C
Sbjct: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC 442



 Score = 64.7 bits (156), Expect = 8e-11
 Identities = 57/233 (24%), Positives = 79/233 (33%), Gaps = 30/233 (12%)

Query: 49  EVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL-RLCFFPFVENGHSESSGQTHLEG 107
           E F Y C   +    +       CTE GW P P C  + C  P++ NG        H  G
Sbjct: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287

Query: 108 DTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDI------- 160
           D +   C  G+      N   C   GW   P+C     T K    P I +G +       
Sbjct: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC-----TLKPCDYPDIKHGGLYHENMRR 342

Query: 161 TSFPLSVYAPASSVEYQCQNLYQLEGNK---RITCRNGQWSEPPKCLHPCVISREIMENY 217
             FP++V        Y C   ++         I C    WS    CL  C      +EN 
Sbjct: 343 PYFPVAV---GKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYF--PYLEN- 396

Query: 218 NIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAK 270
                +          G+S +  C  GY L  ++ T  T   +G    P C +
Sbjct: 397 ----GYNQNHGRKFVQGKSIDVACHPGYAL-PKAQTTVTCMENGWSPTPRCIR 444



 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 47/164 (28%), Positives = 72/164 (43%), Gaps = 18/164 (10%)

Query: 114 CNTGYRLQNNENNISCVERGWSTP-PKCRSTDSTGKCGPPPPIDNGDITSF---PLSVYA 169
           CN GY+L    N   C   GW+   P C       KC P    +NG I S    P   Y 
Sbjct: 114 CNEGYQLLGEINYRECDTDGWTNDIPICEVV----KCLPVTAPENGKIVSSAMEPDREYH 169

Query: 170 PASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPCVISREIMENYNIALRWTAKQ 227
              +V + C + Y++EG++ + C  +G WS E PKC+     S +++    I+      Q
Sbjct: 170 FGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS------Q 223

Query: 228 KLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 271
           K+  +  E  ++ C  GY  S R   + T    G    P+C ++
Sbjct: 224 KIIYKENERFQYKCNMGYEYSERGDAVCTE--SGWRPLPSCEEK 265



 Score = 55.1 bits (131), Expect = 6e-08
 Identities = 50/206 (24%), Positives = 84/206 (40%), Gaps = 23/206 (11%)

Query: 72  CTEEGWS-PTPKCLRLCFFPFV--ENGHSESSG----QTHLEGDTVQIICNTGYRLQNNE 124
           C  +GW+   P C  +   P    ENG   SS     + +  G  V+ +CN+GY+++ +E
Sbjct: 129 CDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE 188

Query: 125 NNISCVERG-WS-TPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLY 182
             + C + G WS   PKC        C  P  I+   I+     +Y      +Y+C   Y
Sbjct: 189 -EMHCSDDGFWSKEKPKCVEI----SCKSPDVINGSPISQ--KIIYKENERFQYKCNMGY 241

Query: 183 QLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCK 242
           +        C    W   P C        +  +N  I     +  ++  RTG+   + C+
Sbjct: 242 EYSERGDAVCTESGWRPLPSC------EEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCR 295

Query: 243 RGYRLSSRSHTLRTTCWDGKLEYPTC 268
            G+  ++R +T + T   G +  P C
Sbjct: 296 NGFYPATRGNTAKCTS-TGWIPAPRC 320



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 23/66 (34%), Positives = 35/66 (53%), Gaps = 7/66 (10%)

Query: 23  CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
           C FP + +G  Y++   + F Q   G+    +C   +  P     T +TC E GWSPTP+
Sbjct: 389 CYFPYLENG--YNQNHGRKFVQ---GKSIDVACHPGYALPKAQ--TTVTCMENGWSPTPR 441

Query: 83  CLRLCF 88
           C+R+ F
Sbjct: 442 CIRVSF 447



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 40/150 (26%), Positives = 54/150 (36%), Gaps = 5/150 (3%)

Query: 100 SGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGD 159
           S QT+ EG      C  GYR   N   + C +  W      R       CG P     G 
Sbjct: 38  SDQTYPEGTQAIYKCRPGYRSLGNVIMV-CRKGEWVALNPLRKCQKR-PCGHPGDTPFGT 95

Query: 160 ITSFPLSVYAPASSVEYQCQNLYQLEG--NKRITCRNGQWSEPPKCLHPCVISREIMENY 217
            T    +V+       Y C   YQL G  N R    +G  ++ P C     +     EN 
Sbjct: 96  FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENG 155

Query: 218 NIALRWTAKQKLYLRTGESAEFVCKRGYRL 247
            I        + Y   G++  FVC  GY++
Sbjct: 156 KIVSSAMEPDREY-HFGQAVRFVCNSGYKI 184



 Score = 31.2 bits (69), Expect = 1.0
 Identities = 16/51 (31%), Positives = 24/51 (47%), Gaps = 2/51 (3%)

Query: 149 CGPPPPIDNGDIT--SFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQW 197
           C   PP  N +I   S+    Y   +   Y+C+  Y+  GN  + CR G+W
Sbjct: 21  CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71


>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
           isoform 2 [Homo sapiens]
          Length = 1033

 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 65/215 (30%), Positives = 84/215 (39%), Gaps = 19/215 (8%)

Query: 45  VPTGEVFYYSCEYNFVSPSKSFWTRITC--TEEGWS-PTPKC-----LRLCFFPFVENGH 96
           +  G V  YSC   F    +     IT    +  W  P PKC        C  P V  G+
Sbjct: 41  IAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGY 100

Query: 97  SESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP--PKCRSTDSTGKCGPPPP 154
                  +  GD+V   C T + +  N++        W     P C S     +C   P 
Sbjct: 101 KIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPL-ECPALPM 159

Query: 155 IDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSE-PPKCLHPCVISRE 212
           I NG  TS  +   AP  SV Y C++ Y L G K I C  +G+WS  PP C      S  
Sbjct: 160 IHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLG 219

Query: 213 IMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 247
              N  +      K+   LR G +A F C  GYRL
Sbjct: 220 RFPNGKV------KEPPILRVGVTANFFCDEGYRL 248



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 61/213 (28%), Positives = 86/213 (40%), Gaps = 19/213 (8%)

Query: 48  GEVFYYSCEYNF-VSPSKSFWTRITCTEEG-WS-PTPKCLRL-----CFFPFVENGHS-E 98
           G    Y C+  F +   K    R      G WS P+P+CLR      C  P V++G+   
Sbjct: 741 GNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLN 800

Query: 99  SSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP--PKCRSTDSTGKCGPPPPID 156
            +   +   D V + CN G+ + N    I C       P  P C      G C PPP   
Sbjct: 801 KTHSAYSHNDIVYVDCNPGF-IMNGSRVIRCHTDNTWVPGVPTCIKKAFIG-CPPPPKTP 858

Query: 157 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEP-PKCLHPCVISREIM 214
           NG+ T   ++ ++P  S+ Y C   Y L G   + C   G WS+P P C      S   M
Sbjct: 859 NGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADM 918

Query: 215 ENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 247
           +     L     +K+Y + G      C+ GY L
Sbjct: 919 DGIQKGLE---PRKMY-QYGAVVTLECEDGYML 947



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 48/190 (25%), Positives = 76/190 (40%), Gaps = 21/190 (11%)

Query: 21  TFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITC-TEEGWSP 79
           T C  P++ HG   +    K  S     ++ Y  C   F+         I C T+  W P
Sbjct: 786 TRCPNPEVKHGYKLN----KTHSAYSHNDIVYVDCNPGFIMNGSRV---IRCHTDNTWVP 838

Query: 80  -TPKCLRLCFF-----PFVENG-HSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVER 132
             P C++  F      P   NG H+  +      G ++   C+ GY L      +   E 
Sbjct: 839 GVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEG 898

Query: 133 GWSTP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRIT 191
            WS P P C+  +    C  P  +D       P  +Y   + V  +C++ Y LEG+ +  
Sbjct: 899 TWSQPAPHCKEVN----CSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQ 954

Query: 192 CRNG-QWSEP 200
           C++  QW+ P
Sbjct: 955 CQSDHQWNPP 964



 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 66/254 (25%), Positives = 102/254 (40%), Gaps = 47/254 (18%)

Query: 19  EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCE------YNFVSPSKSFWTRITC 72
           E  FC  P     IL         + V  G +  Y+C+       NF+   +S    + C
Sbjct: 272 EEIFCPSPP---PILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGES---TLRC 325

Query: 73  TEEG-----WS-PTPKC-----LRLCFFPFVENGHSESSGQT-HLEGDTVQIICNTGYRL 120
           T +      WS P P+C        C  P +  G   S  +  +   DTV   C  G+ L
Sbjct: 326 TVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTL 385

Query: 121 QNNENNISCVERGWSTP--PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQC 178
           + ++  I C  +G   P  P C       +C  PP I NG      +  + P +S++Y C
Sbjct: 386 KGSKQ-IRCNAQGTWEPSAPVCEK-----ECQAPPNILNGQKEDRHMVRFDPGTSIKYSC 439

Query: 179 QNLYQLEGNKRITCRN-GQWSEP-PKC-LHPC-VISREIMENYNIALRWTAKQKLYLRTG 234
              Y L G + I C + G W+ P P+C +  C    R+++         T  Q  ++R  
Sbjct: 440 NPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLL---------TKPQHQFVRPD 490

Query: 235 ESAEFVCKRGYRLS 248
            ++   C  GY+LS
Sbjct: 491 VNSS--CGEGYKLS 502



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 75/327 (22%), Positives = 109/327 (33%), Gaps = 91/327 (27%)

Query: 20  ATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS 78
           A  C  P+I  G +   +K     +    +   ++C + F         +I C  +G W 
Sbjct: 348 AVQCPHPQILRGRMVSGQK----DRYTYNDTVIFACMFGFTLKGSK---QIRCNAQGTWE 400

Query: 79  PT-PKCLRLCFFP-FVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERGWS 135
           P+ P C + C  P  + NG  E       + G +++  CN GY L   E+ I C   G  
Sbjct: 401 PSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEES-IQCTSEGVW 459

Query: 136 TPP----KCRSTDSTGK------------------------------------------- 148
           TPP    K  + ++TG+                                           
Sbjct: 460 TPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEI 519

Query: 149 -------CGPPPPIDNGDITSFPLSVYAPASSVEYQCQN------LYQLEGNKRITC--- 192
                  C PPP I NG  T   L  +   ++V Y C         + L G   I C   
Sbjct: 520 RLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSN 579

Query: 193 --RNGQWSEP-PKCLHPCVISR----EIMENYNIALRWTAKQKLYLRTGESAEFVCKRGY 245
               G WS P P C    +  +     I   Y I    + K+  Y    ++  F C  G+
Sbjct: 580 DQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKI----SGKEAPYF-YNDTVTFKCYSGF 634

Query: 246 RL--SSRSHTLRTTCWDGKLEYPTCAK 270
            L  SS+        WD   E P C K
Sbjct: 635 TLKGSSQIRCKADNTWDP--EIPVCEK 659



 Score = 48.5 bits (114), Expect = 6e-06
 Identities = 41/145 (28%), Positives = 60/145 (41%), Gaps = 30/145 (20%)

Query: 96  HSESSGQTHLEGDTVQII---CNTGYRL--------QNNENNISCVERGWSTPPKCRSTD 144
           H   S Q    G  V+++   C  GY+L        Q+ EN I      +   P C+   
Sbjct: 664 HVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGI-----WFKKIPLCKVIH 718

Query: 145 STGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-----NGQWSE 199
               C PPP I NG  T      +   + V Y+C   + L G K++ CR     +G WS 
Sbjct: 719 ----CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSG 774

Query: 200 P-PKCLHPCVISR----EIMENYNI 219
           P P+CL    ++R    E+   Y +
Sbjct: 775 PSPQCLRSPPVTRCPNPEVKHGYKL 799



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 51/174 (29%), Positives = 67/174 (38%), Gaps = 35/174 (20%)

Query: 53  YSCEYNFVSPSKSFWTRITCTEEG-WSPTP------KCLRLCFFPFVENGHSESSGQTHL 105
           YSCE  ++   +     I C   G WS  P      +C  L  FP   NG  +      +
Sbjct: 181 YSCESGYLLVGEKI---INCLSSGKWSAVPPTCEEARCKSLGRFP---NGKVKEPPILRV 234

Query: 106 EGDTVQIICNTGYRLQNNENNISCVERG----WSTPPKCRSTDSTGKCGPPPPIDNGDIT 161
            G T    C+ GYRLQ   ++  CV  G    W+  P C        C  PPPI NG   
Sbjct: 235 -GVTANFFCDEGYRLQGPPSS-RCVIAGQGVAWTKMPVCEEI----FCPSPPPILNGRHI 288

Query: 162 SFPLSVYAPASSVEYQCQN------LYQLEGNKRITC-----RNGQWSEP-PKC 203
              L+  +  S V Y C         + L G   + C     + G WS P P+C
Sbjct: 289 GNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRC 342



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 35/133 (26%), Positives = 56/133 (42%), Gaps = 22/133 (16%)

Query: 149 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-----RNGQWSEP-PK 202
           CG PPPI NG I+ +   + A  + + Y C   ++L G K + C      +G W +P PK
Sbjct: 23  CGSPPPILNGRISYYSTPI-AVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81

Query: 203 CLHPCVISREIMENYN------IALRWTAKQKLYLRTGESAEFVCKRGYRLS-SRSHTLR 255
           C        E    Y+      +   +  +     R G+S  F CK  + ++ ++S   +
Sbjct: 82  C--------EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133

Query: 256 TTCWDGKLEYPTC 268
                G    PTC
Sbjct: 134 ANNMWGPTRLPTC 146


>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
           isoform 1 [Homo sapiens]
          Length = 1092

 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 65/215 (30%), Positives = 84/215 (39%), Gaps = 19/215 (8%)

Query: 45  VPTGEVFYYSCEYNFVSPSKSFWTRITC--TEEGWS-PTPKC-----LRLCFFPFVENGH 96
           +  G V  YSC   F    +     IT    +  W  P PKC        C  P V  G+
Sbjct: 41  IAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGY 100

Query: 97  SESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP--PKCRSTDSTGKCGPPPP 154
                  +  GD+V   C T + +  N++        W     P C S     +C   P 
Sbjct: 101 KIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPL-ECPALPM 159

Query: 155 IDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSE-PPKCLHPCVISRE 212
           I NG  TS  +   AP  SV Y C++ Y L G K I C  +G+WS  PP C      S  
Sbjct: 160 IHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLG 219

Query: 213 IMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 247
              N  +      K+   LR G +A F C  GYRL
Sbjct: 220 RFPNGKV------KEPPILRVGVTANFFCDEGYRL 248



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 61/213 (28%), Positives = 86/213 (40%), Gaps = 19/213 (8%)

Query: 48   GEVFYYSCEYNF-VSPSKSFWTRITCTEEG-WS-PTPKCLRL-----CFFPFVENGHS-E 98
            G    Y C+  F +   K    R      G WS P+P+CLR      C  P V++G+   
Sbjct: 800  GNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLN 859

Query: 99   SSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP--PKCRSTDSTGKCGPPPPID 156
             +   +   D V + CN G+ + N    I C       P  P C      G C PPP   
Sbjct: 860  KTHSAYSHNDIVYVDCNPGF-IMNGSRVIRCHTDNTWVPGVPTCIKKAFIG-CPPPPKTP 917

Query: 157  NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEP-PKCLHPCVISREIM 214
            NG+ T   ++ ++P  S+ Y C   Y L G   + C   G WS+P P C      S   M
Sbjct: 918  NGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADM 977

Query: 215  ENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 247
            +     L     +K+Y + G      C+ GY L
Sbjct: 978  DGIQKGLE---PRKMY-QYGAVVTLECEDGYML 1006



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 53/196 (27%), Positives = 79/196 (40%), Gaps = 42/196 (21%)

Query: 47  TGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPT-PKCLRLCFFPFVENGHSESSGQTH 104
           +G    Y+C+  ++         I C   G WSP+ P+C   C        H   S Q  
Sbjct: 682 SGMTVDYTCDPGYLLVGNK---SIHCMPSGNWSPSAPRCEETC-------QHVRQSLQEL 731

Query: 105 LEGDTVQII---CNTGYRL--------QNNENNISCVERGWSTPPKCRSTDSTGKCGPPP 153
             G  V+++   C  GY+L        Q+ EN I      +   P C+       C PPP
Sbjct: 732 PAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGI-----WFKKIPLCKVIH----CHPPP 782

Query: 154 PIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-----NGQWSEP-PKCLHPC 207
            I NG  T      +   + V Y+C   + L G K++ CR     +G WS P P+CL   
Sbjct: 783 VIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSP 842

Query: 208 VISR----EIMENYNI 219
            ++R    E+   Y +
Sbjct: 843 PVTRCPNPEVKHGYKL 858



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 48/190 (25%), Positives = 76/190 (40%), Gaps = 21/190 (11%)

Query: 21   TFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITC-TEEGWSP 79
            T C  P++ HG   +    K  S     ++ Y  C   F+         I C T+  W P
Sbjct: 845  TRCPNPEVKHGYKLN----KTHSAYSHNDIVYVDCNPGFIMNGSRV---IRCHTDNTWVP 897

Query: 80   -TPKCLRLCFF-----PFVENG-HSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVER 132
              P C++  F      P   NG H+  +      G ++   C+ GY L      +   E 
Sbjct: 898  GVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEG 957

Query: 133  GWSTP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRIT 191
             WS P P C+  +    C  P  +D       P  +Y   + V  +C++ Y LEG+ +  
Sbjct: 958  TWSQPAPHCKEVN----CSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQ 1013

Query: 192  CRNG-QWSEP 200
            C++  QW+ P
Sbjct: 1014 CQSDHQWNPP 1023



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 57/230 (24%), Positives = 86/230 (37%), Gaps = 40/230 (17%)

Query: 46  PTGEVFYYSC--------EYNFVSPSKSFWTRITCTEEGWS-PTPKC-LRL----CFFPF 91
           P G    Y+C        E++ +  S    T        WS P P C L L    C    
Sbjct: 547 PYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVH 606

Query: 92  VENGHSESSGQT-HLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTDSTGKC 149
           + NG+  S  +  +   DTV   C +G+ L+ +       +  W    P C        C
Sbjct: 607 IANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKG-----C 661

Query: 150 GPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPC 207
             PP + +G  T      +    +V+Y C   Y L GNK I C  +G WS   P+C   C
Sbjct: 662 QSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEETC 721

Query: 208 VISREIMENYNIALRWTAKQKLYLRTGESAEFV---CKRGYRLSSRSHTL 254
              R+ ++               L  G   E V   C+ GY+L+  ++ +
Sbjct: 722 QHVRQSLQE--------------LPAGSRVELVNTSCQDGYQLTGHAYQM 757



 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 66/254 (25%), Positives = 102/254 (40%), Gaps = 47/254 (18%)

Query: 19  EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCE------YNFVSPSKSFWTRITC 72
           E  FC  P     IL         + V  G +  Y+C+       NF+   +S    + C
Sbjct: 272 EEIFCPSPP---PILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGES---TLRC 325

Query: 73  TEEG-----WS-PTPKC-----LRLCFFPFVENGHSESSGQT-HLEGDTVQIICNTGYRL 120
           T +      WS P P+C        C  P +  G   S  +  +   DTV   C  G+ L
Sbjct: 326 TVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTL 385

Query: 121 QNNENNISCVERGWSTP--PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQC 178
           + ++  I C  +G   P  P C       +C  PP I NG      +  + P +S++Y C
Sbjct: 386 KGSKQ-IRCNAQGTWEPSAPVCEK-----ECQAPPNILNGQKEDRHMVRFDPGTSIKYSC 439

Query: 179 QNLYQLEGNKRITCRN-GQWSEP-PKC-LHPC-VISREIMENYNIALRWTAKQKLYLRTG 234
              Y L G + I C + G W+ P P+C +  C    R+++         T  Q  ++R  
Sbjct: 440 NPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLL---------TKPQHQFVRPD 490

Query: 235 ESAEFVCKRGYRLS 248
            ++   C  GY+LS
Sbjct: 491 VNSS--CGEGYKLS 502



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 75/327 (22%), Positives = 109/327 (33%), Gaps = 91/327 (27%)

Query: 20  ATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS 78
           A  C  P+I  G +   +K     +    +   ++C + F         +I C  +G W 
Sbjct: 348 AVQCPHPQILRGRMVSGQK----DRYTYNDTVIFACMFGFTLKGSK---QIRCNAQGTWE 400

Query: 79  PT-PKCLRLCFFP-FVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERGWS 135
           P+ P C + C  P  + NG  E       + G +++  CN GY L   E+ I C   G  
Sbjct: 401 PSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEES-IQCTSEGVW 459

Query: 136 TPP----KCRSTDSTGK------------------------------------------- 148
           TPP    K  + ++TG+                                           
Sbjct: 460 TPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEI 519

Query: 149 -------CGPPPPIDNGDITSFPLSVYAPASSVEYQCQN------LYQLEGNKRITC--- 192
                  C PPP I NG  T   L  +   ++V Y C         + L G   I C   
Sbjct: 520 RLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSN 579

Query: 193 --RNGQWSEP-PKCLHPCVISR----EIMENYNIALRWTAKQKLYLRTGESAEFVCKRGY 245
               G WS P P C    +  +     I   Y I    + K+  Y    ++  F C  G+
Sbjct: 580 DQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKI----SGKEAPYF-YNDTVTFKCYSGF 634

Query: 246 RL--SSRSHTLRTTCWDGKLEYPTCAK 270
            L  SS+        WD   E P C K
Sbjct: 635 TLKGSSQIRCKADNTWDP--EIPVCEK 659



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 51/174 (29%), Positives = 67/174 (38%), Gaps = 35/174 (20%)

Query: 53  YSCEYNFVSPSKSFWTRITCTEEG-WSPTP------KCLRLCFFPFVENGHSESSGQTHL 105
           YSCE  ++   +     I C   G WS  P      +C  L  FP   NG  +      +
Sbjct: 181 YSCESGYLLVGEKI---INCLSSGKWSAVPPTCEEARCKSLGRFP---NGKVKEPPILRV 234

Query: 106 EGDTVQIICNTGYRLQNNENNISCVERG----WSTPPKCRSTDSTGKCGPPPPIDNGDIT 161
            G T    C+ GYRLQ   ++  CV  G    W+  P C        C  PPPI NG   
Sbjct: 235 -GVTANFFCDEGYRLQGPPSS-RCVIAGQGVAWTKMPVCEEI----FCPSPPPILNGRHI 288

Query: 162 SFPLSVYAPASSVEYQCQN------LYQLEGNKRITC-----RNGQWSEP-PKC 203
              L+  +  S V Y C         + L G   + C     + G WS P P+C
Sbjct: 289 GNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRC 342



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 35/133 (26%), Positives = 56/133 (42%), Gaps = 22/133 (16%)

Query: 149 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-----RNGQWSEP-PK 202
           CG PPPI NG I+ +   + A  + + Y C   ++L G K + C      +G W +P PK
Sbjct: 23  CGSPPPILNGRISYYSTPI-AVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81

Query: 203 CLHPCVISREIMENYN------IALRWTAKQKLYLRTGESAEFVCKRGYRLS-SRSHTLR 255
           C        E    Y+      +   +  +     R G+S  F CK  + ++ ++S   +
Sbjct: 82  C--------EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133

Query: 256 TTCWDGKLEYPTC 268
                G    PTC
Sbjct: 134 ANNMWGPTRLPTC 146


>gi|4502503 complement component 4 binding protein, alpha chain
           precursor [Homo sapiens]
          Length = 597

 Score = 72.0 bits (175), Expect = 5e-13
 Identities = 57/192 (29%), Positives = 88/192 (45%), Gaps = 17/192 (8%)

Query: 17  GGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG 76
           G EA  C  PK+N+G +    K +P +      V++Y  E +F     S ++ I   +  
Sbjct: 359 GCEALCCPEPKLNNGEITQHRKSRPANHC----VYFYGDEISFSCHETSRFSAICQGDGT 414

Query: 77  WSP-TPKCLRLCFF-PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
           WSP TP C  +C F P + +GH + S       + +   C+ GY L   +  +SC    W
Sbjct: 415 WSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILV-GQAKLSCSYSHW 473

Query: 135 STP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR 193
           S P P+C++      C  P  + NG + S     Y    +V  QC + Y + G + ITC 
Sbjct: 474 SAPAPQCKAL-----CRKPELV-NGRL-SVDKDQYVEPENVTIQCDSGYGVVGPQSITCS 526

Query: 194 NGQ--WSEPPKC 203
             +  + E PKC
Sbjct: 527 GNRTWYPEVPKC 538



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 50/170 (29%), Positives = 70/170 (41%), Gaps = 21/170 (12%)

Query: 47  TGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPTPKCL-RLCFFPF-VENGHSESSGQT 103
           TG    Y+C   +V    +    +TC  +G W     C+ + C  P  + NG  E     
Sbjct: 73  TGTTLKYTCLPGYVRSHST--QTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDL 130

Query: 104 HLEGDTVQIICNTGYRLQNNENNISCVER---GWSTP-PKCRSTDSTGKCGPPPPIDNGD 159
              G  ++  C+ G+ L  +  +   V+    GWS P P+C       KC PPP I NG 
Sbjct: 131 SF-GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIV----KCKPPPDIRNGR 185

Query: 160 ITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-----RNGQW-SEPPKC 203
             S   + YA   SV Y C   + L G+  I+C       G W   PP C
Sbjct: 186 -HSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTC 234



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 51/239 (21%), Positives = 93/239 (38%), Gaps = 20/239 (8%)

Query: 21  TFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSC-EYNFVSPSKSFWTRITCTEEGWS- 78
           TFC + +  H       + +  + +  G    +SC E  F+  S +    +     GWS 
Sbjct: 106 TFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSH 165

Query: 79  PTPKC--LRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG--- 133
           P P+C  ++    P + NG        +  G +V   C+  + L  + + ISC       
Sbjct: 166 PLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHAS-ISCTVENETI 224

Query: 134 --WS-TPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRI 190
             W  +PP C            P + +G++ S    +Y    ++ ++CQ  + L G+  I
Sbjct: 225 GVWRPSPPTCEKITCR-----KPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVI 279

Query: 191 TC-RNGQWSEPPKCLHP--CVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYR 246
            C  + +W+  P    P  C+   +I            K+ +Y+  G    + C  GY+
Sbjct: 280 HCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYV-VGTVLRYRCHPGYK 337



 Score = 41.6 bits (96), Expect = 7e-04
 Identities = 47/172 (27%), Positives = 66/172 (38%), Gaps = 24/172 (13%)

Query: 48  GEVFYYSCEYNFVSPSKSFWTRITCTEE-GWSPTPKCLRLCF-FPFVENG----HSESSG 101
           G V  Y C   +  P+    T + C +   W+P   C  LC   P + NG    H +S  
Sbjct: 325 GTVLRYRCHPGY-KPTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRP 383

Query: 102 QTH---LEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGK-CGPPPPIDN 157
             H     GD +   C+   R      +  C   G  +P     T S G  C  PP I +
Sbjct: 384 ANHCVYFYGDEISFSCHETSRF-----SAICQGDGTWSP----RTPSCGDICNFPPKIAH 434

Query: 158 GDIT-SFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEP-PKCLHPC 207
           G    S   S +     + Y+C   Y L G  +++C    WS P P+C   C
Sbjct: 435 GHYKQSSSYSFFK--EEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALC 484



 Score = 30.4 bits (67), Expect = 1.7
 Identities = 26/106 (24%), Positives = 44/106 (41%), Gaps = 12/106 (11%)

Query: 147 GKCGPPPPIDNG---DITSFPLSVYAPASSVEYQCQNLY-QLEGNKRITCR-NGQWSEPP 201
           G CGPPP +      DIT    + +   ++++Y C   Y +    + +TC  +G+W    
Sbjct: 48  GNCGPPPTLSFAAPMDIT-LTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT 106

Query: 202 KCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 247
            C++        + N  + +      K  L  G   EF C  G+ L
Sbjct: 107 FCIYKRCRHPGELRNGQVEI------KTDLSFGSQIEFSCSEGFFL 146


>gi|153266841 apolipoprotein H precursor [Homo sapiens]
          Length = 345

 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 59/211 (27%), Positives = 85/211 (40%), Gaps = 19/211 (9%)

Query: 72  CTEEG-WSPT-PKCLRL-CFFPFVENG-----HSESSGQTHLEGDTVQIICNTGYRLQNN 123
           CTEEG WSP  P C  + C  P +        +  S+G   L  DT    C   + +  N
Sbjct: 124 CTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGN 183

Query: 124 ENNISCVERG-WSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLY 182
           +  I+C   G W+  P+CR      KC  P   DNG +               + C + Y
Sbjct: 184 DT-ITCTTHGNWTKLPECREV----KCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGY 238

Query: 183 QLEGNKRITC-RNGQWSEPPKCLHPC--VISREIMENYNIALRWTAKQKLYLRTGESAEF 239
            L+G + I C + G WS  P C   C   + +  +      ++   K K  +  G+   F
Sbjct: 239 SLDGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSF 298

Query: 240 VCKRGYRLSSRSHTLRTTCWDGKLEYPTCAK 270
            CK   +    S+T    C DG +E P C K
Sbjct: 299 FCKN--KEKKCSYTEDAQCIDGTIEVPKCFK 327



 Score = 58.2 bits (139), Expect = 8e-09
 Identities = 69/234 (29%), Positives = 100/234 (42%), Gaps = 50/234 (21%)

Query: 41  PFSQVPTGEVFY-------YSCEYNFVSPSKSFWTRITCTEEGWSP--TPKCL-RLC-FF 89
           PFS V   + FY       YSC+  +VS  +    +  C   G  P  T KC  R+C F 
Sbjct: 30  PFSTVVPLKTFYEPGEEITYSCKPGYVS--RGGMRKFICPLTGLWPINTLKCTPRVCPFA 87

Query: 90  PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP--PKCRSTDSTG 147
             +ENG    +  T    +T+   CNTG+ L N  ++  C E G  +P  P C       
Sbjct: 88  GILENGAVRYT--TFEYPNTISFSCNTGFYL-NGADSAKCTEEGKWSPELPVCAPI---- 140

Query: 148 KCGPPPPIDNGDITSFPLSVYAPAS--------SVEYQCQNLYQLEGNKRITC-RNGQWS 198
              PPP I     T   L VY P++        +  ++C   + + GN  ITC  +G W+
Sbjct: 141 -ICPPPSIP----TFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT 195

Query: 199 EPPKCLHPCVISREIMENY-----NIALRWTAKQKLYLRTGESAEFVCKRGYRL 247
           + P+C       RE+   +     N  + + AK  LY +  + A F C  GY L
Sbjct: 196 KLPEC-------REVKCPFPSRPDNGFVNYPAKPTLYYK--DKATFGCHDGYSL 240


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score = 65.1 bits (157), Expect = 6e-11
 Identities = 67/241 (27%), Positives = 98/241 (40%), Gaps = 31/241 (12%)

Query: 39   YKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS-PTPKCLRLCFF--PFVEN 94
            Y   S    G +  YSC   F    +    + TC   G WS P P C  +     P VEN
Sbjct: 2156 YASGSNYSFGAMVAYSCNKGFYIKGEK---KSTCEATGQWSSPIPTCHPVSCGEPPKVEN 2212

Query: 95   GHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW--STPPKCRSTDSTGKCGPP 152
            G  E +     E + V+  CN GY+   +   +    R W   +P  C   D    CG P
Sbjct: 2213 GFLEHTTGRIFESE-VRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLD----CGKP 2267

Query: 153  PPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEP--PKCLHPCVI 209
            PPI NG +      V    S V++ C   Y+L G+   TC ++G+W++   PKC+     
Sbjct: 2268 PPIQNGFMKGENFEV---GSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCP 2324

Query: 210  SREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRS--HTLRTTCWDGKLEYPT 267
               ++EN  +    T +  +         F CK G+ L   S    L +  W+    +P 
Sbjct: 2325 EPPLLENQLVLKELTTEVGV-------VTFSCKEGHVLQGPSVLKCLPSQQWND--SFPV 2375

Query: 268  C 268
            C
Sbjct: 2376 C 2376



 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 62/218 (28%), Positives = 85/218 (38%), Gaps = 38/218 (17%)

Query: 47   TGEVFYYSCEYNFVSPSKSFW----TRITCTEEG-WSPT-PKCLRL-CFFPFV-ENGHSE 98
            +GE++    E  F S  + +     T+ITC E G W+   P C  + C  P + ENG  E
Sbjct: 1801 SGEIYTVGAEVTF-SCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIE 1859

Query: 99   SSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWS-TPPKCRSTDSTGKCGPPPPIDN 157
                T   G  V   CN GY L  ++ +       WS +PP C       KC  P  I+N
Sbjct: 1860 ELAFTF--GSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPV----KCSSPENINN 1913

Query: 158  GDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEPPKCLH------PCVIS 210
            G    + LS     S+  Y C   Y L+G   I C  +G W   P   H      P  I 
Sbjct: 1914 G---KYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIK 1970

Query: 211  REIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLS 248
              ++   N   R             +  + CK GY L+
Sbjct: 1971 DAVITGNNFTFR------------NTVTYTCKEGYTLA 1996



 Score = 61.2 bits (147), Expect = 9e-10
 Identities = 53/162 (32%), Positives = 69/162 (42%), Gaps = 19/162 (11%)

Query: 93   ENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG-WS-TPPKCRSTDSTGKCG 150
            ENGHS  SG+ +  G  V   C  GY+L      I+C+E G W+   P C++      CG
Sbjct: 1796 ENGHS--SGEIYTVGAEVTFSCQEGYQLM-GVTKITCLESGEWNHLIPYCKAV----SCG 1848

Query: 151  PPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEPPKCLHPCVI 209
             P   +NG I       +   S V Y+C   Y L G+K  +C  N  WS  P    P   
Sbjct: 1849 KPAIPENGCIEEL---AFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKC 1905

Query: 210  SREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRS 251
            S    EN N   ++      YL T   A + C  GY L   S
Sbjct: 1906 SSP--ENINNG-KYILSGLTYLST---ASYSCDTGYSLQGPS 1941



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 37/126 (29%), Positives = 58/126 (46%), Gaps = 12/126 (9%)

Query: 96   HSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTDSTGKCGPPPP 154
            H  ++ +    G  V + C+ G++L  N       +  W+ P P C        CG PPP
Sbjct: 1640 HLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERIS----CGVPPP 1695

Query: 155  IDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCL--HPCVIS 210
            ++NG  ++     +   S+V YQC N Y L G+ R+ C  NG W+   P CL    C + 
Sbjct: 1696 LENGFHSA---DDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVG 1752

Query: 211  REIMEN 216
             +  E+
Sbjct: 1753 SDCSEH 1758



 Score = 54.7 bits (130), Expect = 8e-08
 Identities = 54/185 (29%), Positives = 79/185 (42%), Gaps = 24/185 (12%)

Query: 90   PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTDSTGK 148
            P +  G    S   H  G TV+  C  G+ L+ N   +   +  WS+P P+C   +    
Sbjct: 2385 PLISFGVPIPSSALHF-GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVE---- 2439

Query: 149  CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQW--SEPPKCLH 205
            C  P  I NG I    L   A  S+  Y C+  ++L GN    C  NG W   +P     
Sbjct: 2440 CPQPEEIPNGIIDVQGL---AYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAI 2496

Query: 206  PCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRS--HTLRTTCWDGKL 263
             C+  +EI+   N    +T      L  G++  + C RG+RL   S    L T  WD  +
Sbjct: 2497 ECLKPKEIL---NGKFSYTD-----LHYGQTVTYSCNRGFRLEGPSALTCLETGDWD--V 2546

Query: 264  EYPTC 268
            + P+C
Sbjct: 2547 DAPSC 2551



 Score = 54.7 bits (130), Expect = 8e-08
 Identities = 57/201 (28%), Positives = 86/201 (42%), Gaps = 25/201 (12%)

Query: 70   ITCTEEG-WSPT-PKCLRL-CFFPFV-ENGHSESSGQTHLEGDTVQIICNTGYRLQNNEN 125
            + C E+G W+ + P C+ + C  P   ENG    + +T + G  VQ  C  G+ L  ++ 
Sbjct: 2697 LICQEDGTWNGSAPSCISIECDLPTAPENGFLRFT-ETSM-GSAVQYSCKPGHILAGSDL 2754

Query: 126  NISCVERGWS-TPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQL 184
             +    R WS   P+C +      C  P P+ NG I     S Y   S++ Y+C   Y L
Sbjct: 2755 RLCLENRKWSGASPRCEAIS----CKKPNPVMNGSIKG---SNYTYLSTLYYECDPGYVL 2807

Query: 185  EGNKRITCRNGQ-WSE-PPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCK 242
             G +R TC++ + W E  P C+     S  +  N  +       QK         E+ C 
Sbjct: 2808 NGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQK-------EIEYTCN 2860

Query: 243  RGYRL-SSRSHT-LRTTCWDG 261
             G+ L  +RS   L    W G
Sbjct: 2861 EGFLLEGARSRVCLANGSWSG 2881



 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 60/236 (25%), Positives = 89/236 (37%), Gaps = 43/236 (18%)

Query: 45   VPTGEVFYYSCE--------YNFVSPSKSFWTRITCTEEG-WSPTPKCLRLCFFPFVEN- 94
            V TGE   Y  E        Y   + + +F    TC ++G W P          P  EN 
Sbjct: 3132 VATGEAHTYESEVKLRCLEGYTMDTDTDTF----TCQKDGRWFPERISCSPKKCPLPENI 3187

Query: 95   GHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPP 154
             H    G        V + C  GY  +    ++  ++  W  PP    + S   CG P  
Sbjct: 3188 THILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWE-PPFSDESCSPVSCGKPES 3246

Query: 155  IDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS------EPPKCLHPC 207
             ++G +     S Y   S++ YQC+  Y+LEGN+   C+ N QWS      +  +C  P 
Sbjct: 3247 PEHGFVVG---SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPL 3303

Query: 208  --VISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLS--SRSHTLRTTCW 259
              +  +  +EN                TG +  + C RGY L   S +H      W
Sbjct: 3304 EFLNGKADIENRT--------------TGPNVVYSCNRGYSLEGPSEAHCTENGTW 3345



 Score = 51.2 bits (121), Expect = 9e-07
 Identities = 50/205 (24%), Positives = 82/205 (40%), Gaps = 20/205 (9%)

Query: 69   RITCTEEG-W-SPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENN 126
            ++TC  +G W +  P C  +   P  +  H   +G + + G  +Q  C  GY+L  N + 
Sbjct: 2928 KLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSR 2987

Query: 127  ISCVERGWS-TPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLE 185
                   WS + P C       +C   P I+ G +     + +    +   QC   ++L 
Sbjct: 2988 RCLSNGSWSGSSPSCLPC----RCS-TPVIEYGTVNG---TDFDCGKAARIQCFKGFKLL 3039

Query: 186  GNKRITCR-NGQWSEP-PKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKR 243
            G   ITC  +GQWS   P C H    S  ++ N  I+   + K+ +         + C+ 
Sbjct: 3040 GLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKENV-------ITYSCRS 3092

Query: 244  GYRLSSRSHTLRTTCWDGKLEYPTC 268
            GY +   S  + T        YP C
Sbjct: 3093 GYVIQGSSDLICTEKGVWSQPYPVC 3117



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 49/213 (23%), Positives = 81/213 (38%), Gaps = 28/213 (13%)

Query: 70   ITCTEEG-WSPTPK-CLRL-CFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENN 126
            I C  +G WS + + CL + C  P + + H+       L GD     C+ GY L +N   
Sbjct: 2001 IECLADGKWSRSDQQCLAVSCDEPPIVD-HASPETAHRLFGDIAFYYCSDGYSLADNSQL 2059

Query: 127  ISCVERGWSTP-----PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 181
            +   +  W  P     P+C +      C  PP +    + S   + +A  S V ++C   
Sbjct: 2060 LCNAQGKWVPPEGQDMPRCIAHF----CEKPPSVSYSILESVSKAKFAAGSVVSFKCMEG 2115

Query: 182  YQLEGNKRITC-RNGQWSEPPKCLHPCVISR-----EIMENYNIALRWTAKQKLYLRTGE 235
            + L  + +I C R GQW+  P  +  C+  R      IM  Y     ++         G 
Sbjct: 2116 FVLNTSAKIECMRGGQWNPSPMSIQ-CIPVRCGEPPSIMNGYASGSNYS--------FGA 2166

Query: 236  SAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 268
               + C +G+ +     +            PTC
Sbjct: 2167 MVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTC 2199



 Score = 48.5 bits (114), Expect = 6e-06
 Identities = 61/235 (25%), Positives = 85/235 (36%), Gaps = 60/235 (25%)

Query: 72   CTEEG-WS-PTPKCLRLCFF--PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNI 127
            C  +G W+ P P C R+     P +ENG    S      G TV   CN GY L   ++ +
Sbjct: 1672 CLNQGQWTQPLPHCERISCGVPPPLENGFH--SADDFYAGSTVTYQCNNGYYLLG-DSRM 1728

Query: 128  SCVERG-WS-TPPKCRSTDS----------------------------TG---------K 148
             C + G W+   P C   D                             TG         K
Sbjct: 1729 FCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIK 1788

Query: 149  CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSE-PPKCLHP 206
            C  P   +NG  +     +Y   + V + CQ  YQL G  +ITC  +G+W+   P C   
Sbjct: 1789 CKAPGNPENGHSSG---EIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAV 1845

Query: 207  CVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLS--SRSHTLRTTCW 259
                  I EN  I       ++L    G    + C +GY L+    S  L  + W
Sbjct: 1846 SCGKPAIPENGCI-------EELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSW 1893



 Score = 48.5 bits (114), Expect = 6e-06
 Identities = 44/159 (27%), Positives = 67/159 (42%), Gaps = 20/159 (12%)

Query: 53   YSCEYNFVSPSKSFWTRITCTEEG-W---SPTPKCLRLCFFPFVENGHSESSGQTHLEGD 108
            Y+C+  F        T   C E G W    PT K +       + NG    +   +  G 
Sbjct: 2464 YTCKPGFELVGN---TTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHY--GQ 2518

Query: 109  TVQIICNTGYRLQNNENNISCVERG-WSTP-PKCRSTDSTGKCGPPPPIDNGDITSFPLS 166
            TV   CN G+RL+   + ++C+E G W    P C +      C  P PI+NG +     +
Sbjct: 2519 TVTYSCNRGFRLEG-PSALTCLETGDWDVDAPSCNAIH----CDSPQPIENGFVEG---A 2570

Query: 167  VYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEP-PKCL 204
             Y+  + + Y C   +Q+ G+   TC    WS   P C+
Sbjct: 2571 DYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSIPTCM 2609



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 40/158 (25%), Positives = 64/158 (40%), Gaps = 17/158 (10%)

Query: 52   YYSCEYNFVSPSKSFWTRITCTEE-GWSPT-PKCLRL-CFFPFVENGHSESSGQTHLEGD 108
            YY C+  +V        R TC ++  W    P C+ + C  P V + + +  G  +    
Sbjct: 2798 YYECDPGYVLNGTE---RRTCQDDKNWDEDEPICIPVDCSSPPV-SANGQVRGDEYTFQK 2853

Query: 109  TVQIICNTGYRLQNNENNISCVERGWS-TPPKCRSTDSTGKCGPPPPIDNGDITSFPLSV 167
             ++  CN G+ L+   + +      WS   P C       +C  PP + NG         
Sbjct: 2854 EIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPV----RCATPPQLANGVTEGLD--- 2906

Query: 168  YAPASSVEYQCQNLYQLEGNKRITCR-NGQW-SEPPKC 203
            Y     V + C   Y L G  ++TC+ +G W +E P C
Sbjct: 2907 YGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLC 2944



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 70/285 (24%), Positives = 104/285 (36%), Gaps = 74/285 (25%)

Query: 42   FSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS-PTPKCLRL-CFFPF-VENGHS 97
            ++ +  G+   YSC   F     S    +TC E G W    P C  + C  P  +ENG  
Sbjct: 2511 YTDLHYGQTVTYSCNRGFRLEGPS---ALTCLETGDWDVDAPSCNAIHCDSPQPIENGFV 2567

Query: 98   ESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTDSTGKCGPPPPID 156
            E +  ++  G  +   C  G+++  +    +C E GWS+  P C   D    CG PP ID
Sbjct: 2568 EGADYSY--GAIIIYSCFPGFQVAGHAMQ-TCEESGWSSSIPTCMPID----CGLPPHID 2620

Query: 157  NGDITSF-----------------------PLSVYAPASS-------------------- 173
             GD T                         P  + A A +                    
Sbjct: 2621 FGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTM 2680

Query: 174  VEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLH-PCVISREIMENYNIALRWTAKQKLY 230
            V Y C   Y+L GN  + C+ +G W+   P C+   C +       +   LR+T      
Sbjct: 2681 VSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGF---LRFTETS--- 2734

Query: 231  LRTGESAEFVCKRGYRL--SSRSHTLRTTCWDG---KLEYPTCAK 270
               G + ++ CK G+ L  S     L    W G   + E  +C K
Sbjct: 2735 --MGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKK 2777



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 49/175 (28%), Positives = 71/175 (40%), Gaps = 26/175 (14%)

Query: 96   HSESSGQTH----LEGDTVQIICNTGYRLQNNENNISCVERGWS-TPPKCRSTDSTGKCG 150
            +++ S  TH    L G  V   CN GY L  N   I   +  W+ + P C S +    C 
Sbjct: 2663 NTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIE----CD 2718

Query: 151  PPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNK-RITCRNGQWS-EPPKC-LHPC 207
             P   +NG +     S+    S+V+Y C+  + L G+  R+   N +WS   P+C    C
Sbjct: 2719 LPTAPENGFLRFTETSM---GSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISC 2775

Query: 208  VISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGK 262
                 +M        +T    LY        + C  GY L+    T R TC D K
Sbjct: 2776 KKPNPVMNGSIKGSNYTYLSTLY--------YECDPGYVLNG---TERRTCQDDK 2819



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 36/142 (25%), Positives = 58/142 (40%), Gaps = 31/142 (21%)

Query: 70   ITCT-EEGWSPTP-KCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNI 127
            ITC  +E W+ T  KC ++   P     ++ + G  +  GD +   C +GY L+    ++
Sbjct: 3396 ITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSV 3455

Query: 128  SCVERG-WSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEG 186
             C+E G W++PP CR+           P  NG I   P +   P   +            
Sbjct: 3456 -CLENGTWTSPPICRAVCRF-------PCQNGGICQRPNACSCPEGWM------------ 3495

Query: 187  NKRITCRNGQWSEPPKCLHPCV 208
                    G+  E P C+ PC+
Sbjct: 3496 --------GRLCEEPICILPCL 3509



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 42/172 (24%), Positives = 54/172 (31%), Gaps = 64/172 (37%)

Query: 94   NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG-WSTPP-------------- 138
            NG ++   +T   G  V   CN GY L+   +   C E G WS P               
Sbjct: 3307 NGKADIENRT--TGPNVVYSCNRGYSLE-GPSEAHCTENGTWSHPVPLCKPNPCPVPFVI 3363

Query: 139  -------------------KCRS------------------TDSTGK-----CGPPPPID 156
                               KCR                   T ++ K     CGPP  ++
Sbjct: 3364 PENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVE 3423

Query: 157  NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEPPKCLHPC 207
            N          Y     + Y C + Y LEG  R  C  NG W+ PP C   C
Sbjct: 3424 NAIARGVH---YQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVC 3472



 Score = 37.0 bits (84), Expect = 0.018
 Identities = 26/96 (27%), Positives = 46/96 (47%), Gaps = 7/96 (7%)

Query: 178 CQNLYQLEGNKRITCR-NGQWSEP-PKCLHPCVISREIMENYNIALRWTAKQKLYLRTGE 235
           C   Y+LEG+ ++TC+ N QW  P P+C+     + ++ ++  I+     KQ    + G 
Sbjct: 466 CDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQP--AKFGT 523

Query: 236 SAEFVCKRGYRLSSRSHTLRTTC---WDGKLEYPTC 268
                C++G+ LS     LR T    W+  ++   C
Sbjct: 524 ICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVC 559



 Score = 30.0 bits (66), Expect = 2.2
 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)

Query: 70  ITCTEEG-WSPTPKCLRLCFFPFV---ENGHSESSGQTHLEGDTVQIICNTGYRLQNNEN 125
           I C   G WS +    R+   P +   ++GH   S +  L   T  + C+ GYRL+ ++ 
Sbjct: 418 ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK 477

Query: 126 NISCVERGWSTP-PKC 140
                   W  P P+C
Sbjct: 478 LTCQGNSQWDGPEPRC 493


>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
          Length = 2489

 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 67/240 (27%), Positives = 99/240 (41%), Gaps = 40/240 (16%)

Query: 48   GEVFYYSCEYNFVSPSKSFWTRI--TCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHL 105
            G++F  SC  N V      W+ +   C  +   P P+       PF  NG    +  T  
Sbjct: 1882 GKMFSISCLENLV------WSSVEDNCRRKSCGPPPE-------PF--NGMVHINTDTQF 1926

Query: 106  EGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPL 165
             G TV   CN G+RL  + +    V     T  K         C PPP I NGD  S   
Sbjct: 1927 -GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNR 1985

Query: 166  SVYAPASSVEYQC------QNLYQLEGNKRITCRN-----GQWSE-PPKCLHPCVISREI 213
            + +   + V YQC      + L++L G + I C +     G WS  PP+C+     +   
Sbjct: 1986 TSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPE 2045

Query: 214  MENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTC---WDGKLEYPTCAK 270
            +EN   A+R    +  +  T E   F C+ G+ +   SHT++      W  KL  P C++
Sbjct: 2046 VEN---AIRVPGNRSFFTLT-EIIRFRCQPGFVMVG-SHTVQCQTNGRWGPKL--PHCSR 2098



 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 61/243 (25%), Positives = 92/243 (37%), Gaps = 33/243 (13%)

Query: 26   PKINHGILYDEEKYKPFSQVPTGEVFYYSCE--------YNFVSPSKSFWTRITCTEEGW 77
            P I++G  Y   +    +    G V  Y C         +  V     + T        W
Sbjct: 1973 PTISNGDFYSNNR----TSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVW 2028

Query: 78   S-PTPKCLRL--CFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERG 133
            S P P+C+    C  P VEN       ++     + ++  C  G+ +  + + + C   G
Sbjct: 2029 SSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGS-HTVQCQTNG 2087

Query: 134  WSTP--PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRIT 191
               P  P C        C PPP I +G+ T      ++P   V Y C+  Y L G   + 
Sbjct: 2088 RWGPKLPHCSRV-----CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH 2142

Query: 192  CR-NGQWS-EPPKC-LHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLS 248
            C   G WS E P+C +  C      + +  + L       L L+ G    FVC  G+RL 
Sbjct: 2143 CTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLL------PLNLQLGAKVSFVCDEGFRLK 2196

Query: 249  SRS 251
             RS
Sbjct: 2197 GRS 2199



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 54/187 (28%), Positives = 76/187 (40%), Gaps = 23/187 (12%)

Query: 77   WS-PTPKCL--RLCFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVER 132
            WS P P+C+    C  P VENG   S  ++     + V+  C  G+ +      + C   
Sbjct: 1575 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF-VMKGPRRVKCQAL 1633

Query: 133  GWSTP--PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRI 190
                P  P C        C PPP I +G+ T      ++P   V Y C+  Y L G   +
Sbjct: 1634 NKWEPELPSCSRV-----CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASL 1688

Query: 191  TCR-NGQWS-EPPKC-LHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 247
             C   G WS E P+C +  C      + +  +         L L+ G    FVC  G+RL
Sbjct: 1689 HCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLF------PLNLQLGAKVSFVCDEGFRL 1742

Query: 248  --SSRSH 252
              SS SH
Sbjct: 1743 KGSSVSH 1749



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 58/210 (27%), Positives = 89/210 (42%), Gaps = 26/210 (12%)

Query: 77   WSPTPK-CLRL-CFFP-FVENGHSESSGQTHLE-GDTVQIICNTGYRLQN-----NENNI 127
            WS  P  C R+ C  P  + NG   S+ + +   G  V   CN G R +       E +I
Sbjct: 1504 WSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSI 1563

Query: 128  SCVERG-----WSTP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 181
             C         WS P P+C   +   KC  PP ++NG + S   S+++    VE++CQ  
Sbjct: 1564 YCTSNDDQVGIWSGPAPQCIIPN---KC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPG 1619

Query: 182  YQLEGNKRITCRN-GQWS-EPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEF 239
            + ++G +R+ C+   +W  E P C   C    EI+   +     T   +     G+   +
Sbjct: 1620 FVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEH-----TPSHQDNFSPGQEVFY 1674

Query: 240  VCKRGYRLSSRSHTLRTTCWDGKLEYPTCA 269
             C+ GY L   +    T   D   E P CA
Sbjct: 1675 SCEPGYDLRGAASLHCTPQGDWSPEAPRCA 1704



 Score = 54.7 bits (130), Expect = 8e-08
 Identities = 56/194 (28%), Positives = 80/194 (41%), Gaps = 31/194 (15%)

Query: 32  ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPT-PKC-LRLC- 87
           +L+ E   +       G+  +YSCE  +     +    + CT +G WSP  P C ++ C 
Sbjct: 303 VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA---SMRCTPQGDWSPAAPTCEVKSCD 359

Query: 88  -FFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----W-STPPKCR 141
            F   + NG         L G  V  +C+ G++L+ +  +  CV  G    W S+ P C 
Sbjct: 360 DFMGQLLNGRVLFPVNLQL-GAKVDFVCDEGFQLKGSSASY-CVLAGMESLWNSSVPVCE 417

Query: 142 STDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGNKRITCR-- 193
                  C  PP I NG  T  PL V+    +V Y C         + L G   I C   
Sbjct: 418 QIF----CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSD 473

Query: 194 ---NGQWSEP-PKC 203
              NG WS P P+C
Sbjct: 474 PQGNGVWSSPAPRC 487



 Score = 54.7 bits (130), Expect = 8e-08
 Identities = 56/194 (28%), Positives = 80/194 (41%), Gaps = 31/194 (15%)

Query: 32  ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPT-PKC-LRLC- 87
           +L+ E   +       G+  +YSCE  +     +    + CT +G WSP  P C ++ C 
Sbjct: 753 VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA---SMRCTPQGDWSPAAPTCEVKSCD 809

Query: 88  -FFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----W-STPPKCR 141
            F   + NG         L G  V  +C+ G++L+ +  +  CV  G    W S+ P C 
Sbjct: 810 DFMGQLLNGRVLFPVNLQL-GAKVDFVCDEGFQLKGSSASY-CVLAGMESLWNSSVPVCE 867

Query: 142 STDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGNKRITCR-- 193
                  C  PP I NG  T  PL V+    +V Y C         + L G   I C   
Sbjct: 868 QIF----CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSD 923

Query: 194 ---NGQWSEP-PKC 203
              NG WS P P+C
Sbjct: 924 PQGNGVWSSPAPRC 937



 Score = 54.7 bits (130), Expect = 8e-08
 Identities = 56/194 (28%), Positives = 80/194 (41%), Gaps = 31/194 (15%)

Query: 32   ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPT-PKC-LRLC- 87
            +L+ E   +       G+  +YSCE  +     +    + CT +G WSP  P C ++ C 
Sbjct: 1203 VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA---SMRCTPQGDWSPAAPTCEVKSCD 1259

Query: 88   -FFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----W-STPPKCR 141
             F   + NG         L G  V  +C+ G++L+ +  +  CV  G    W S+ P C 
Sbjct: 1260 DFMGQLLNGRVLFPVNLQL-GAKVDFVCDEGFQLKGSSASY-CVLAGMESLWNSSVPVCE 1317

Query: 142  STDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGNKRITCR-- 193
                   C  PP I NG  T  PL V+    +V Y C         + L G   I C   
Sbjct: 1318 QIF----CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSD 1373

Query: 194  ---NGQWSEP-PKC 203
               NG WS P P+C
Sbjct: 1374 PQGNGVWSSPAPRC 1387



 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 64/244 (26%), Positives = 99/244 (40%), Gaps = 37/244 (15%)

Query: 48  GEVFYYSCE--YNFVSPSKSFWTRITCTEEG----W-SPTPKCLRL-CFFP-FVENGHSE 98
           G    YSC   Y  +  S +     TC   G    W + TP C R+ C  P  + NG   
Sbjct: 124 GSQIKYSCTKGYRLIGSSSA-----TCIISGDTVIWDNETPICDRIPCGLPPTITNGDFI 178

Query: 99  SSGQTHLE-GDTVQIICNTGYRLQN-----NENNISCVERG-----WSTP-PKCRSTDST 146
           S+ + +   G  V   CN G   +       E +I C         WS P P+C   +  
Sbjct: 179 STNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPN-- 236

Query: 147 GKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRN-GQWS-EPPKCL 204
            KC  PP ++NG + S   S+++    VE++CQ  + ++G +R+ C+   +W  E P C 
Sbjct: 237 -KC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCS 294

Query: 205 HPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLE 264
             C    +++         T + K     G+   + C+ GY L   +    T   D    
Sbjct: 295 RVCQPPPDVLH-----AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPA 349

Query: 265 YPTC 268
            PTC
Sbjct: 350 APTC 353



 Score = 51.6 bits (122), Expect = 7e-07
 Identities = 55/209 (26%), Positives = 87/209 (41%), Gaps = 26/209 (12%)

Query: 77  WSPTPK-CLRL-CFFP-FVENGHSESSGQTHLE-GDTVQIICNTGYRLQN-----NENNI 127
           WS  P  C R+ C  P  + NG   S+ + +   G  V   CN G   +       E +I
Sbjct: 604 WSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSI 663

Query: 128 SCVERG-----WSTP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 181
            C         WS P P+C   +   KC  PP ++NG + S   S+++    VE++CQ  
Sbjct: 664 YCTSNDDQVGIWSGPAPQCIIPN---KC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPG 719

Query: 182 YQLEGNKRITCRN-GQWS-EPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEF 239
           + ++G +R+ C+   +W  E P C   C    +++         T + K     G+   +
Sbjct: 720 FVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH-----AERTQRDKDNFSPGQEVFY 774

Query: 240 VCKRGYRLSSRSHTLRTTCWDGKLEYPTC 268
            C+ GY L   +    T   D     PTC
Sbjct: 775 SCEPGYDLRGAASMRCTPQGDWSPAAPTC 803



 Score = 51.6 bits (122), Expect = 7e-07
 Identities = 55/209 (26%), Positives = 87/209 (41%), Gaps = 26/209 (12%)

Query: 77   WSPTPK-CLRL-CFFP-FVENGHSESSGQTHLE-GDTVQIICNTGYRLQN-----NENNI 127
            WS  P  C R+ C  P  + NG   S+ + +   G  V   CN G   +       E +I
Sbjct: 1054 WSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSI 1113

Query: 128  SCVERG-----WSTP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 181
             C         WS P P+C   +   KC  PP ++NG + S   S+++    VE++CQ  
Sbjct: 1114 YCTSNDDQVGIWSGPAPQCIIPN---KC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPG 1169

Query: 182  YQLEGNKRITCRN-GQWS-EPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEF 239
            + ++G +R+ C+   +W  E P C   C    +++         T + K     G+   +
Sbjct: 1170 FVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH-----AERTQRDKDNFSPGQEVFY 1224

Query: 240  VCKRGYRLSSRSHTLRTTCWDGKLEYPTC 268
             C+ GY L   +    T   D     PTC
Sbjct: 1225 SCEPGYDLRGAASMRCTPQGDWSPAAPTC 1253



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 56/210 (26%), Positives = 83/210 (39%), Gaps = 39/210 (18%)

Query: 19   EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCE--------YNFVSPSKSFWTRI 70
            E  FC  P     IL       PF  +P G+   Y+C+        +N +  S      I
Sbjct: 2220 EQIFCPNPP---AILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESS-----I 2271

Query: 71   TCTEEG-----WS-PTPKC-----LRLCFFPFVENGHSESSGQT-HLEGDTVQIICNTGY 118
             CT +      WS P P+C           P ++NGH      + +L G T+  IC+ GY
Sbjct: 2272 RCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGY 2331

Query: 119  RLQNNENNISCVERG-WSTPPK-CRSTDSTGKCGPPPPIDNGDITSFPLS-VYAPASSVE 175
             L   +  I C ++G WS     C+  + +      P   NG      +  VY     V 
Sbjct: 2332 LLVG-KGFIFCTDQGIWSQLDHYCKEVNCSF-----PLFMNGISKELEMKKVYHYGDYVT 2385

Query: 176  YQCQNLYQLEGNKRITCRNGQWSEPP--KC 203
             +C++ Y LEG+    C+     +PP  KC
Sbjct: 2386 LKCEDGYTLEGSPWSQCQADDRWDPPLAKC 2415



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 60/236 (25%), Positives = 87/236 (36%), Gaps = 30/236 (12%)

Query: 32   ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSP-TPKC-LRLCF 88
            IL+ E           G+  +YSCE  +     +    + CT +G WSP  P+C ++ C 
Sbjct: 1653 ILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAA---SLHCTPQGDWSPEAPRCAVKSCD 1709

Query: 89   FPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERG----WSTP-PKCRS 142
                +  H       +L+ G  V  +C+ G+RL+ +  +  CV  G    W+   P C  
Sbjct: 1710 DFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVS-HCVLVGMRSLWNNSVPVCEH 1768

Query: 143  TDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGNKRITCR--- 193
                  C  PP I NG  T  P         + Y C         + L G   I C    
Sbjct: 1769 IF----CPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDP 1824

Query: 194  --NGQWSEP-PKC-LHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGY 245
              NG WS P P+C L       +  E +  A             G S  + C+ GY
Sbjct: 1825 HGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGY 1880



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 34/119 (28%), Positives = 53/119 (44%), Gaps = 12/119 (10%)

Query: 134  WSTP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC 192
            WS+P P+C  +     C  PP I NG      +S+Y P  ++ Y C   Y L G   I C
Sbjct: 2283 WSSPAPRCELSVPAA-CPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFC 2341

Query: 193  RN-GQWSEPPKCLHPCVISREIMENYNIALRWTAKQ---KLYLRTGESAEFVCKRGYRL 247
             + G WS+     H C   +E+  ++ + +   +K+   K     G+     C+ GY L
Sbjct: 2342 TDQGIWSQLD---HYC---KEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTL 2394


>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
          Length = 2039

 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 67/240 (27%), Positives = 99/240 (41%), Gaps = 40/240 (16%)

Query: 48   GEVFYYSCEYNFVSPSKSFWTRI--TCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHL 105
            G++F  SC  N V      W+ +   C  +   P P+       PF  NG    +  T  
Sbjct: 1432 GKMFSISCLENLV------WSSVEDNCRRKSCGPPPE-------PF--NGMVHINTDTQF 1476

Query: 106  EGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPL 165
             G TV   CN G+RL  + +    V     T  K         C PPP I NGD  S   
Sbjct: 1477 -GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNR 1535

Query: 166  SVYAPASSVEYQC------QNLYQLEGNKRITCRN-----GQWSE-PPKCLHPCVISREI 213
            + +   + V YQC      + L++L G + I C +     G WS  PP+C+     +   
Sbjct: 1536 TSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPE 1595

Query: 214  MENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTC---WDGKLEYPTCAK 270
            +EN   A+R    +  +  T E   F C+ G+ +   SHT++      W  KL  P C++
Sbjct: 1596 VEN---AIRVPGNRSFFTLT-EIIRFRCQPGFVMVG-SHTVQCQTNGRWGPKL--PHCSR 1648



 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 61/243 (25%), Positives = 92/243 (37%), Gaps = 33/243 (13%)

Query: 26   PKINHGILYDEEKYKPFSQVPTGEVFYYSCE--------YNFVSPSKSFWTRITCTEEGW 77
            P I++G  Y   +    +    G V  Y C         +  V     + T        W
Sbjct: 1523 PTISNGDFYSNNR----TSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVW 1578

Query: 78   S-PTPKCLRL--CFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERG 133
            S P P+C+    C  P VEN       ++     + ++  C  G+ +  + + + C   G
Sbjct: 1579 SSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGS-HTVQCQTNG 1637

Query: 134  WSTP--PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRIT 191
               P  P C        C PPP I +G+ T      ++P   V Y C+  Y L G   + 
Sbjct: 1638 RWGPKLPHCSRV-----CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH 1692

Query: 192  CR-NGQWS-EPPKC-LHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLS 248
            C   G WS E P+C +  C      + +  + L       L L+ G    FVC  G+RL 
Sbjct: 1693 CTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLL------PLNLQLGAKVSFVCDEGFRLK 1746

Query: 249  SRS 251
             RS
Sbjct: 1747 GRS 1749



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 54/187 (28%), Positives = 76/187 (40%), Gaps = 23/187 (12%)

Query: 77   WS-PTPKCL--RLCFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVER 132
            WS P P+C+    C  P VENG   S  ++     + V+  C  G+ +      + C   
Sbjct: 1125 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF-VMKGPRRVKCQAL 1183

Query: 133  GWSTP--PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRI 190
                P  P C        C PPP I +G+ T      ++P   V Y C+  Y L G   +
Sbjct: 1184 NKWEPELPSCSRV-----CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASL 1238

Query: 191  TCR-NGQWS-EPPKC-LHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 247
             C   G WS E P+C +  C      + +  +         L L+ G    FVC  G+RL
Sbjct: 1239 HCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLF------PLNLQLGAKVSFVCDEGFRL 1292

Query: 248  --SSRSH 252
              SS SH
Sbjct: 1293 KGSSVSH 1299



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 58/210 (27%), Positives = 89/210 (42%), Gaps = 26/210 (12%)

Query: 77   WSPTPK-CLRL-CFFP-FVENGHSESSGQTHLE-GDTVQIICNTGYRLQN-----NENNI 127
            WS  P  C R+ C  P  + NG   S+ + +   G  V   CN G R +       E +I
Sbjct: 1054 WSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSI 1113

Query: 128  SCVERG-----WSTP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 181
             C         WS P P+C   +   KC  PP ++NG + S   S+++    VE++CQ  
Sbjct: 1114 YCTSNDDQVGIWSGPAPQCIIPN---KC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPG 1169

Query: 182  YQLEGNKRITCRN-GQWS-EPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEF 239
            + ++G +R+ C+   +W  E P C   C    EI+   +     T   +     G+   +
Sbjct: 1170 FVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEH-----TPSHQDNFSPGQEVFY 1224

Query: 240  VCKRGYRLSSRSHTLRTTCWDGKLEYPTCA 269
             C+ GY L   +    T   D   E P CA
Sbjct: 1225 SCEPGYDLRGAASLHCTPQGDWSPEAPRCA 1254



 Score = 54.7 bits (130), Expect = 8e-08
 Identities = 56/194 (28%), Positives = 80/194 (41%), Gaps = 31/194 (15%)

Query: 32  ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPT-PKC-LRLC- 87
           +L+ E   +       G+  +YSCE  +     +    + CT +G WSP  P C ++ C 
Sbjct: 303 VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA---SMRCTPQGDWSPAAPTCEVKSCD 359

Query: 88  -FFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----W-STPPKCR 141
            F   + NG         L G  V  +C+ G++L+ +  +  CV  G    W S+ P C 
Sbjct: 360 DFMGQLLNGRVLFPVNLQL-GAKVDFVCDEGFQLKGSSASY-CVLAGMESLWNSSVPVCE 417

Query: 142 STDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGNKRITCR-- 193
                  C  PP I NG  T  PL V+    +V Y C         + L G   I C   
Sbjct: 418 QIF----CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSD 473

Query: 194 ---NGQWSEP-PKC 203
              NG WS P P+C
Sbjct: 474 PQGNGVWSSPAPRC 487



 Score = 54.7 bits (130), Expect = 8e-08
 Identities = 56/194 (28%), Positives = 80/194 (41%), Gaps = 31/194 (15%)

Query: 32  ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPT-PKC-LRLC- 87
           +L+ E   +       G+  +YSCE  +     +    + CT +G WSP  P C ++ C 
Sbjct: 753 VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA---SMRCTPQGDWSPAAPTCEVKSCD 809

Query: 88  -FFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----W-STPPKCR 141
            F   + NG         L G  V  +C+ G++L+ +  +  CV  G    W S+ P C 
Sbjct: 810 DFMGQLLNGRVLFPVNLQL-GAKVDFVCDEGFQLKGSSASY-CVLAGMESLWNSSVPVCE 867

Query: 142 STDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGNKRITCR-- 193
                  C  PP I NG  T  PL V+    +V Y C         + L G   I C   
Sbjct: 868 QIF----CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSD 923

Query: 194 ---NGQWSEP-PKC 203
              NG WS P P+C
Sbjct: 924 PQGNGVWSSPAPRC 937



 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 64/244 (26%), Positives = 99/244 (40%), Gaps = 37/244 (15%)

Query: 48  GEVFYYSCE--YNFVSPSKSFWTRITCTEEG----W-SPTPKCLRL-CFFP-FVENGHSE 98
           G    YSC   Y  +  S +     TC   G    W + TP C R+ C  P  + NG   
Sbjct: 124 GSQIKYSCTKGYRLIGSSSA-----TCIISGDTVIWDNETPICDRIPCGLPPTITNGDFI 178

Query: 99  SSGQTHLE-GDTVQIICNTGYRLQN-----NENNISCVERG-----WSTP-PKCRSTDST 146
           S+ + +   G  V   CN G   +       E +I C         WS P P+C   +  
Sbjct: 179 STNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPN-- 236

Query: 147 GKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRN-GQWS-EPPKCL 204
            KC  PP ++NG + S   S+++    VE++CQ  + ++G +R+ C+   +W  E P C 
Sbjct: 237 -KC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCS 294

Query: 205 HPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLE 264
             C    +++         T + K     G+   + C+ GY L   +    T   D    
Sbjct: 295 RVCQPPPDVLH-----AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPA 349

Query: 265 YPTC 268
            PTC
Sbjct: 350 APTC 353



 Score = 51.6 bits (122), Expect = 7e-07
 Identities = 55/209 (26%), Positives = 87/209 (41%), Gaps = 26/209 (12%)

Query: 77  WSPTPK-CLRL-CFFP-FVENGHSESSGQTHLE-GDTVQIICNTGYRLQN-----NENNI 127
           WS  P  C R+ C  P  + NG   S+ + +   G  V   CN G   +       E +I
Sbjct: 604 WSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSI 663

Query: 128 SCVERG-----WSTP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 181
            C         WS P P+C   +   KC  PP ++NG + S   S+++    VE++CQ  
Sbjct: 664 YCTSNDDQVGIWSGPAPQCIIPN---KC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPG 719

Query: 182 YQLEGNKRITCRN-GQWS-EPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEF 239
           + ++G +R+ C+   +W  E P C   C    +++         T + K     G+   +
Sbjct: 720 FVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH-----AERTQRDKDNFSPGQEVFY 774

Query: 240 VCKRGYRLSSRSHTLRTTCWDGKLEYPTC 268
            C+ GY L   +    T   D     PTC
Sbjct: 775 SCEPGYDLRGAASMRCTPQGDWSPAAPTC 803



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 56/210 (26%), Positives = 83/210 (39%), Gaps = 39/210 (18%)

Query: 19   EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCE--------YNFVSPSKSFWTRI 70
            E  FC  P     IL       PF  +P G+   Y+C+        +N +  S      I
Sbjct: 1770 EQIFCPNPP---AILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESS-----I 1821

Query: 71   TCTEEG-----WS-PTPKC-----LRLCFFPFVENGHSESSGQT-HLEGDTVQIICNTGY 118
             CT +      WS P P+C           P ++NGH      + +L G T+  IC+ GY
Sbjct: 1822 RCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGY 1881

Query: 119  RLQNNENNISCVERG-WSTPPK-CRSTDSTGKCGPPPPIDNGDITSFPLS-VYAPASSVE 175
             L   +  I C ++G WS     C+  + +      P   NG      +  VY     V 
Sbjct: 1882 LLVG-KGFIFCTDQGIWSQLDHYCKEVNCSF-----PLFMNGISKELEMKKVYHYGDYVT 1935

Query: 176  YQCQNLYQLEGNKRITCRNGQWSEPP--KC 203
             +C++ Y LEG+    C+     +PP  KC
Sbjct: 1936 LKCEDGYTLEGSPWSQCQADDRWDPPLAKC 1965



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 60/236 (25%), Positives = 87/236 (36%), Gaps = 30/236 (12%)

Query: 32   ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSP-TPKC-LRLCF 88
            IL+ E           G+  +YSCE  +     +    + CT +G WSP  P+C ++ C 
Sbjct: 1203 ILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAA---SLHCTPQGDWSPEAPRCAVKSCD 1259

Query: 89   FPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERG----WSTP-PKCRS 142
                +  H       +L+ G  V  +C+ G+RL+ +  +  CV  G    W+   P C  
Sbjct: 1260 DFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVS-HCVLVGMRSLWNNSVPVCEH 1318

Query: 143  TDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGNKRITCR--- 193
                  C  PP I NG  T  P         + Y C         + L G   I C    
Sbjct: 1319 IF----CPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDP 1374

Query: 194  --NGQWSEP-PKC-LHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGY 245
              NG WS P P+C L       +  E +  A             G S  + C+ GY
Sbjct: 1375 HGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGY 1430



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 34/119 (28%), Positives = 53/119 (44%), Gaps = 12/119 (10%)

Query: 134  WSTP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC 192
            WS+P P+C  +     C  PP I NG      +S+Y P  ++ Y C   Y L G   I C
Sbjct: 1833 WSSPAPRCELSVPAA-CPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFC 1891

Query: 193  RN-GQWSEPPKCLHPCVISREIMENYNIALRWTAKQ---KLYLRTGESAEFVCKRGYRL 247
             + G WS+     H C   +E+  ++ + +   +K+   K     G+     C+ GY L
Sbjct: 1892 TDQGIWSQLD---HYC---KEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTL 1944


>gi|168693643 decay accelerating factor for complement isoform 2
           precursor [Homo sapiens]
          Length = 440

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 59/194 (30%), Positives = 83/194 (42%), Gaps = 26/194 (13%)

Query: 23  CDFP-KINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV-SPSKSFWTRITCTEE-GWSP 79
           C+ P ++N   L  ++ Y   +  P G V  Y C   +   PS S   ++TC +   WS 
Sbjct: 98  CEVPTRLNSASL--KQPYITQNYFPVGTVVEYECRPGYRREPSLS--PKLTCLQNLKWST 153

Query: 80  TPKCLRLCFFPF---VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG--- 133
             +  +    P    + NG  +  G   L G T+   CNTGY+L  + ++  C+  G   
Sbjct: 154 AVEFCKKKSCPNPGEIRNGQIDVPGGI-LFGATISFSCNTGYKLFGSTSSF-CLISGSSV 211

Query: 134 -WSTP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRIT 191
            WS P P+CR       C  PP IDNG I       Y    SV Y C   + + G   I 
Sbjct: 212 QWSDPLPECREI----YCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKGFTMIGEHSIY 266

Query: 192 CR----NGQWSEPP 201
           C      G+WS PP
Sbjct: 267 CTVNNDEGEWSGPP 280



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 32/133 (24%), Positives = 58/133 (43%), Gaps = 13/133 (9%)

Query: 147 GKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLY-QLEGNK-RITCRNG-QWSEPPK- 202
           G CG PP + N        + +   + + Y+C+  + ++ G K  + C  G QWS+  + 
Sbjct: 34  GDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEF 93

Query: 203 CLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYR----LSSRSHTLRTTC 258
           C   C +   +    + +L+     + Y   G   E+ C+ GYR    LS +   L+   
Sbjct: 94  CNRSCEVPTRL---NSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLK 150

Query: 259 WDGKLEYPTCAKR 271
           W   +E+  C K+
Sbjct: 151 WSTAVEF--CKKK 161


>gi|10835143 decay accelerating factor for complement isoform 1
           preproprotein [Homo sapiens]
          Length = 381

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 59/194 (30%), Positives = 83/194 (42%), Gaps = 26/194 (13%)

Query: 23  CDFP-KINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV-SPSKSFWTRITCTEE-GWSP 79
           C+ P ++N   L  ++ Y   +  P G V  Y C   +   PS S   ++TC +   WS 
Sbjct: 98  CEVPTRLNSASL--KQPYITQNYFPVGTVVEYECRPGYRREPSLS--PKLTCLQNLKWST 153

Query: 80  TPKCLRLCFFPF---VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG--- 133
             +  +    P    + NG  +  G   L G T+   CNTGY+L  + ++  C+  G   
Sbjct: 154 AVEFCKKKSCPNPGEIRNGQIDVPGGI-LFGATISFSCNTGYKLFGSTSSF-CLISGSSV 211

Query: 134 -WSTP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRIT 191
            WS P P+CR       C  PP IDNG I       Y    SV Y C   + + G   I 
Sbjct: 212 QWSDPLPECREI----YCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKGFTMIGEHSIY 266

Query: 192 CR----NGQWSEPP 201
           C      G+WS PP
Sbjct: 267 CTVNNDEGEWSGPP 280



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 32/133 (24%), Positives = 58/133 (43%), Gaps = 13/133 (9%)

Query: 147 GKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLY-QLEGNK-RITCRNG-QWSEPPK- 202
           G CG PP + N        + +   + + Y+C+  + ++ G K  + C  G QWS+  + 
Sbjct: 34  GDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEF 93

Query: 203 CLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYR----LSSRSHTLRTTC 258
           C   C +   +    + +L+     + Y   G   E+ C+ GYR    LS +   L+   
Sbjct: 94  CNRSCEVPTRL---NSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLK 150

Query: 259 WDGKLEYPTCAKR 271
           W   +E+  C K+
Sbjct: 151 WSTAVEF--CKKK 161


>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
          Length = 3667

 Score = 58.5 bits (140), Expect = 6e-09
 Identities = 71/234 (30%), Positives = 100/234 (42%), Gaps = 34/234 (14%)

Query: 48   GEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS-PTPKCLRL-CFFPFVENGHSESSGQTH 104
            G V +Y C   +     S    + C   G W  P P+C+ + C  P V   ++  SG+ +
Sbjct: 2916 GTVVFYDCNPGYFLFGSSV---LICQPNGQWDKPLPECIMIDCGHPGVPP-NAVLSGEKY 2971

Query: 105  LEGDTVQIICNTGYRLQNNENNISCVERG-WS-TPPKCRSTDSTGKCGPPPPIDNGDITS 162
              G TV   C TG R    +++ +C   G WS + P C S D+TG CG P    +G   S
Sbjct: 2972 TFGSTVHYSC-TGKRSLLGQSSRTCQLNGHWSGSQPHC-SGDATGTCGDPGTPGHG---S 3026

Query: 163  FPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWS-EPPKCLHPCVISREIMENYNIA 220
               S +   S+V Y C   Y L G++  TC  NG W+   P+C        + ++  N  
Sbjct: 3027 RQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC--------KAVQCGNPG 3078

Query: 221  LRWTAKQKLYLRTG----ESAEFVCKRGYRLSSRSHTLRTT--CWDGKLEYPTC 268
               TA  K++   G     S  + C  GY LS  S    T    W G L  P C
Sbjct: 3079 T--TANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTL--PNC 3128



 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 68/261 (26%), Positives = 96/261 (36%), Gaps = 42/261 (16%)

Query: 23   CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSC--EYNFVSPSKSFWTRITCTEEG-WSP 79
            C  P +    +   EKY        G   +YSC  + + +  S       TC   G WS 
Sbjct: 2955 CGHPGVPPNAVLSGEKYT------FGSTVHYSCTGKRSLLGQSSR-----TCQLNGHWSG 3003

Query: 80   T-PKC----LRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
            + P C       C  P    GH            TV+  C+TGY L  +E         W
Sbjct: 3004 SQPHCSGDATGTCGDPGTP-GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSW 3062

Query: 135  S-TPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR 193
            +   P+C++     +CG P    NG +  F +     +SSV Y C   Y L G     C 
Sbjct: 3063 TGRQPECKAV----QCGNPGTTANGKV--FRIDGTTFSSSVIYSCMEGYILSGPSVRQCT 3116

Query: 194  -NGQWSEP-PKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRS 251
             NG WS   P C         I  N    LR+     +    G++  ++C+ GY +    
Sbjct: 3117 ANGTWSGTLPNCTIISCGDPGIPAN---GLRYGDDYVV----GQNVSYMCQPGYTMELNG 3169

Query: 252  HTLRTT----CWDGKLEYPTC 268
              +RT      W G +  PTC
Sbjct: 3170 SRIRTCTINGTWSGVM--PTC 3188



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 54/215 (25%), Positives = 82/215 (38%), Gaps = 23/215 (10%)

Query: 53   YSCEYNFVSPSKSFWTRITCTEEGWS-PTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQ 111
            Y C   F     S   RI   +  WS   P C+ +         +  +SG      D V 
Sbjct: 2801 YQCNPGFRLIGSS--VRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVT 2858

Query: 112  IICNTGYRLQNNENNISCVERGWS-TPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAP 170
              CN GY +Q          R WS  PP C+  + +    P  P ++   +      +  
Sbjct: 2859 FSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCS---DPGIPANSKRESKIEHGNFTY 2915

Query: 171  ASSVEYQCQNLYQLEGNKRITCR-NGQWSEP-PKCL-----HPCVISREIM--ENY---- 217
             + V Y C   Y L G+  + C+ NGQW +P P+C+     HP V    ++  E Y    
Sbjct: 2916 GTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGS 2975

Query: 218  NIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSH 252
             +    T K+ L    G+S+      G+   S+ H
Sbjct: 2976 TVHYSCTGKRSL---LGQSSRTCQLNGHWSGSQPH 3007



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 43/165 (26%), Positives = 66/165 (40%), Gaps = 18/165 (10%)

Query: 43   SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPTP-KCLR-LCFFP-FVENGHSE 98
            +Q   G    ++C+  F+    +      C   G WS +  +CL   C  P  + NG  +
Sbjct: 2733 TQTSYGSTAIFTCDLGFMLVGSAVRE---CLSSGLWSESETRCLAGHCGIPELIVNG--Q 2787

Query: 99   SSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTDSTGKCGPPPPIDN 157
              G+ +   DTV   CN G+RL  +   I   +  WS   P C        CG P     
Sbjct: 2788 VIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV----SCGHPGSPIY 2843

Query: 158  GDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWSEPP 201
            G  +    + +     V + C   Y ++G  +  C+ N QWS PP
Sbjct: 2844 GRTSG---NGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPP 2885



 Score = 38.1 bits (87), Expect = 0.008
 Identities = 22/77 (28%), Positives = 36/77 (46%), Gaps = 5/77 (6%)

Query: 149  CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSE----PPKCL 204
            C PPPP+ N +I +     +     + YQC   + L GN  +TCR G+  +    PP C 
Sbjct: 2355 CQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2413

Query: 205  HPCVISREIMENYNIAL 221
              C  +   +++  + L
Sbjct: 2414 VLCPANELRLDSTGVIL 2430



 Score = 36.6 bits (83), Expect = 0.024
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 5/43 (11%)

Query: 170  PASSVEYQCQNLYQLEGNKRITCRNGQ----WS-EPPKCLHPC 207
            P  +V +QC   Y+L+G +RITC   +    W   PP C+ PC
Sbjct: 1506 PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1548



 Score = 33.9 bits (76), Expect = 0.15
 Identities = 26/87 (29%), Positives = 36/87 (41%), Gaps = 14/87 (16%)

Query: 168  YAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCLHPC----------VISREI 213
            Y     V +QC   Y L+G+  ITC  G   +W+ P P CL  C          ++S   
Sbjct: 2028 YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGF 2087

Query: 214  MENYNIALRWTAKQKLYLRTGESAEFV 240
              NY  +L  T    L +  G   +FV
Sbjct: 2088 PGNYPSSLDCTWTINLPIGFGVHLQFV 2114



 Score = 33.5 bits (75), Expect = 0.20
 Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 14/65 (21%)

Query: 174 VEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPC----------VISREIMENY--NI 219
           + ++CQ  ++L G K I C+ N QWS   P C+ PC          V+S +  E Y  N+
Sbjct: 646 LRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNL 705

Query: 220 ALRWT 224
              WT
Sbjct: 706 NCIWT 710



 Score = 33.1 bits (74), Expect = 0.26
 Identities = 19/63 (30%), Positives = 29/63 (46%), Gaps = 7/63 (11%)

Query: 149  CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCL 204
            C  P P  NG +     +V     ++ ++C   Y L GN  +TC +G    W+ P P+C 
Sbjct: 2184 CPDPRPFRNGFVIGNDFTV---GQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCE 2240

Query: 205  HPC 207
              C
Sbjct: 2241 ALC 2243



 Score = 32.0 bits (71), Expect = 0.59
 Identities = 22/66 (33%), Positives = 34/66 (51%), Gaps = 12/66 (18%)

Query: 107  GDTVQIICNTGYRLQNNENNISCV---ERGWSTP-PKCRSTDSTGKCGPPPPIDNGDITS 162
            GDT+   C++GYRL+   + I C+    R WS P P+C       +CG     + G + S
Sbjct: 1161 GDTLTFSCSSGYRLEGT-SEIICLGGGRRVWSAPLPRC-----VAECGASATNNEGILLS 1214

Query: 163  --FPLS 166
              +PL+
Sbjct: 1215 PNYPLN 1220



 Score = 30.8 bits (68), Expect = 1.3
 Identities = 34/121 (28%), Positives = 46/121 (38%), Gaps = 29/121 (23%)

Query: 61   SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSG----------QTHLEGDTV 110
            S S   W       EG   T +  +L +  F E  H E  G          Q H  G T+
Sbjct: 1282 STSNQLWLEFNSDTEG---TDEGFQLVYTSF-ELSHCEDPGIPQFGYKISDQGHFAGSTI 1337

Query: 111  QIICNTGYRLQNNENNISCV---ERGWSTP-PKCRST-------DSTGKC---GPPPPID 156
               CN GY L +  + + C+    R W  P P C +        +S+G+    G P P D
Sbjct: 1338 IYGCNPGYTL-HGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYD 1396

Query: 157  N 157
            N
Sbjct: 1397 N 1397



 Score = 30.4 bits (67), Expect = 1.7
 Identities = 16/46 (34%), Positives = 20/46 (43%), Gaps = 1/46 (2%)

Query: 96   HSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKC 140
            H    G     G TV   C++GYRL + E  +      WS P P C
Sbjct: 978  HGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1023



 Score = 30.4 bits (67), Expect = 1.7
 Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 4/39 (10%)

Query: 173  SVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCLHPC 207
            ++ + C + Y+LEG   I C  G    WS P P+C+  C
Sbjct: 1163 TLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAEC 1201



 Score = 30.4 bits (67), Expect = 1.7
 Identities = 25/87 (28%), Positives = 32/87 (36%), Gaps = 19/87 (21%)

Query: 149  CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEP------PK 202
            C  P  I NG         Y   S+V Y C   Y L+G   +TC  G    P      P 
Sbjct: 1661 CFDPGNIMNGTRLGMD---YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1717

Query: 203  CLHPC----------VISREIMENYNI 219
            C  PC          V+S    +NY++
Sbjct: 1718 CHAPCGSRSTGSEGTVLSPNYPKNYSV 1744



 Score = 30.4 bits (67), Expect = 1.7
 Identities = 49/175 (28%), Positives = 65/175 (37%), Gaps = 32/175 (18%)

Query: 50   VFYYSCEYNF--VSPSKSFWTRITCTEEGW-SPTPKCLRL-CFFPFVE-NGHSESSGQTH 104
            V  ++C+  F  V  S +   + +     W +P P C  + C  P    NG   ++   +
Sbjct: 2551 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTD--Y 2608

Query: 105  LEGDTVQIICNTGYRLQNNE-NNISCVERG-WSTPPKCRSTDSTGKCGPPPPIDNGDITS 162
            L G  V   CN GYRL + E     C   G WS   K      T +C     +    I S
Sbjct: 2609 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNK------TPRC---VVVTCPSINS 2659

Query: 163  FPL----------SVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWS---EPPKC 203
            F L          S Y   + V + C   Y   G   I C  NG WS   E P C
Sbjct: 2660 FILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYC 2714



 Score = 28.9 bits (63), Expect = 5.0
 Identities = 16/46 (34%), Positives = 22/46 (47%), Gaps = 6/46 (13%)

Query: 168  YAPASSVEYQCQNLYQLEGNKRITCRN-----GQWSEP-PKCLHPC 207
            +A  SSV + C   Y L G+  I C        QW++  P C+ PC
Sbjct: 1854 FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPC 1899



 Score = 28.5 bits (62), Expect = 6.5
 Identities = 21/80 (26%), Positives = 35/80 (43%), Gaps = 13/80 (16%)

Query: 117 GYRL---QNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASS 173
           G++L   ++N N  S +  G           ++  C  P   +NG       S+    S+
Sbjct: 418 GFKLFPGKDNSNKFSILNEGGIKT-------ASNLCPDPGEPENGKRIGSDFSL---GST 467

Query: 174 VEYQCQNLYQLEGNKRITCR 193
           V++ C   Y L+G K ITC+
Sbjct: 468 VQFSCDEDYVLQGAKSITCQ 487



 Score = 28.5 bits (62), Expect = 6.5
 Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 5/44 (11%)

Query: 101  GQTHLEGDTVQIICNTGYRLQNNENNISCVE---RGWSTP-PKC 140
            G  ++ GD V   C+ GY LQ + ++I+C+    R W+ P P C
Sbjct: 2025 GDRYMVGDVVSFQCDQGYSLQGH-SHITCMPGPVRRWNYPIPIC 2067



 Score = 28.1 bits (61), Expect = 8.5
 Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 6/46 (13%)

Query: 100  SGQTHLEGDTVQIICNTGYRLQNNENNISCVE----RGWS-TPPKC 140
            +G     GDTV   C+ GY LQ  E  I+C++      W  +PP C
Sbjct: 1500 NGDGREPGDTVVFQCDPGYELQ-GEERITCIQVENRYFWQPSPPVC 1544


>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
            sapiens]
          Length = 3538

 Score = 58.5 bits (140), Expect = 6e-09
 Identities = 71/234 (30%), Positives = 100/234 (42%), Gaps = 34/234 (14%)

Query: 48   GEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS-PTPKCLRL-CFFPFVENGHSESSGQTH 104
            G V +Y C   +     S    + C   G W  P P+C+ + C  P V   ++  SG+ +
Sbjct: 2787 GTVVFYDCNPGYFLFGSSV---LICQPNGQWDKPLPECIMIDCGHPGVPP-NAVLSGEKY 2842

Query: 105  LEGDTVQIICNTGYRLQNNENNISCVERG-WS-TPPKCRSTDSTGKCGPPPPIDNGDITS 162
              G TV   C TG R    +++ +C   G WS + P C S D+TG CG P    +G   S
Sbjct: 2843 TFGSTVHYSC-TGKRSLLGQSSRTCQLNGHWSGSQPHC-SGDATGTCGDPGTPGHG---S 2897

Query: 163  FPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWS-EPPKCLHPCVISREIMENYNIA 220
               S +   S+V Y C   Y L G++  TC  NG W+   P+C        + ++  N  
Sbjct: 2898 RQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC--------KAVQCGNPG 2949

Query: 221  LRWTAKQKLYLRTG----ESAEFVCKRGYRLSSRSHTLRTT--CWDGKLEYPTC 268
               TA  K++   G     S  + C  GY LS  S    T    W G L  P C
Sbjct: 2950 T--TANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTL--PNC 2999



 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 68/261 (26%), Positives = 96/261 (36%), Gaps = 42/261 (16%)

Query: 23   CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSC--EYNFVSPSKSFWTRITCTEEG-WSP 79
            C  P +    +   EKY        G   +YSC  + + +  S       TC   G WS 
Sbjct: 2826 CGHPGVPPNAVLSGEKYT------FGSTVHYSCTGKRSLLGQSSR-----TCQLNGHWSG 2874

Query: 80   T-PKC----LRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
            + P C       C  P    GH            TV+  C+TGY L  +E         W
Sbjct: 2875 SQPHCSGDATGTCGDPGTP-GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSW 2933

Query: 135  S-TPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR 193
            +   P+C++     +CG P    NG +  F +     +SSV Y C   Y L G     C 
Sbjct: 2934 TGRQPECKAV----QCGNPGTTANGKV--FRIDGTTFSSSVIYSCMEGYILSGPSVRQCT 2987

Query: 194  -NGQWSEP-PKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRS 251
             NG WS   P C         I  N    LR+     +    G++  ++C+ GY +    
Sbjct: 2988 ANGTWSGTLPNCTIISCGDPGIPAN---GLRYGDDYVV----GQNVSYMCQPGYTMELNG 3040

Query: 252  HTLRTT----CWDGKLEYPTC 268
              +RT      W G +  PTC
Sbjct: 3041 SRIRTCTINGTWSGVM--PTC 3059



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 54/215 (25%), Positives = 82/215 (38%), Gaps = 23/215 (10%)

Query: 53   YSCEYNFVSPSKSFWTRITCTEEGWS-PTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQ 111
            Y C   F     S   RI   +  WS   P C+ +         +  +SG      D V 
Sbjct: 2672 YQCNPGFRLIGSS--VRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVT 2729

Query: 112  IICNTGYRLQNNENNISCVERGWS-TPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAP 170
              CN GY +Q          R WS  PP C+  + +    P  P ++   +      +  
Sbjct: 2730 FSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCS---DPGIPANSKRESKIEHGNFTY 2786

Query: 171  ASSVEYQCQNLYQLEGNKRITCR-NGQWSEP-PKCL-----HPCVISREIM--ENY---- 217
             + V Y C   Y L G+  + C+ NGQW +P P+C+     HP V    ++  E Y    
Sbjct: 2787 GTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGS 2846

Query: 218  NIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSH 252
             +    T K+ L    G+S+      G+   S+ H
Sbjct: 2847 TVHYSCTGKRSL---LGQSSRTCQLNGHWSGSQPH 2878



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 43/165 (26%), Positives = 66/165 (40%), Gaps = 18/165 (10%)

Query: 43   SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPTP-KCLR-LCFFP-FVENGHSE 98
            +Q   G    ++C+  F+    +      C   G WS +  +CL   C  P  + NG  +
Sbjct: 2604 TQTSYGSTAIFTCDLGFMLVGSAVRE---CLSSGLWSESETRCLAGHCGIPELIVNG--Q 2658

Query: 99   SSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTDSTGKCGPPPPIDN 157
              G+ +   DTV   CN G+RL  +   I   +  WS   P C        CG P     
Sbjct: 2659 VIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV----SCGHPGSPIY 2714

Query: 158  GDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWSEPP 201
            G  +    + +     V + C   Y ++G  +  C+ N QWS PP
Sbjct: 2715 GRTSG---NGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPP 2756



 Score = 38.1 bits (87), Expect = 0.008
 Identities = 22/77 (28%), Positives = 36/77 (46%), Gaps = 5/77 (6%)

Query: 149  CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSE----PPKCL 204
            C PPPP+ N +I +     +     + YQC   + L GN  +TCR G+  +    PP C 
Sbjct: 2291 CQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2349

Query: 205  HPCVISREIMENYNIAL 221
              C  +   +++  + L
Sbjct: 2350 VLCPANELRLDSTGVIL 2366



 Score = 36.6 bits (83), Expect = 0.024
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 5/43 (11%)

Query: 170  PASSVEYQCQNLYQLEGNKRITCRNGQ----WS-EPPKCLHPC 207
            P  +V +QC   Y+L+G +RITC   +    W   PP C+ PC
Sbjct: 1442 PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1484



 Score = 36.6 bits (83), Expect = 0.024
 Identities = 63/238 (26%), Positives = 94/238 (39%), Gaps = 42/238 (17%)

Query: 50   VFYYSCEYNF--VSPSKSFWTRITCTEEGW-SPTPKCLRL-CFFPFVE-NGHSESSGQTH 104
            V  ++C+  F  V  S +   + +     W +P P C  + C  P    NG   ++   +
Sbjct: 2487 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTD--Y 2544

Query: 105  LEGDTVQIICNTGYRLQNNE-NNISCVERG-WST---PPKCRSTDSTGKCG--PPPPIDN 157
            L G  V   CN GYRL + E     C   G WS     P+C        CG  P PP  N
Sbjct: 2545 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRC----VVISCGELPTPPNGN 2600

Query: 158  --GDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSE-PPKCL-HPCVISRE 212
              G  TS+        S+  + C   + L G+    C  +G WSE   +CL   C I   
Sbjct: 2601 KIGTQTSY-------GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPEL 2653

Query: 213  IMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTL--RTTCWDGKLEYPTC 268
            I+    I   +  +        ++  + C  G+RL   S  +  +   W G+L  P+C
Sbjct: 2654 IVNGQVIGENYGYR--------DTVVYQCNPGFRLIGSSVRICQQDHNWSGQL--PSC 2701



 Score = 33.9 bits (76), Expect = 0.15
 Identities = 26/87 (29%), Positives = 36/87 (41%), Gaps = 14/87 (16%)

Query: 168  YAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCLHPC----------VISREI 213
            Y     V +QC   Y L+G+  ITC  G   +W+ P P CL  C          ++S   
Sbjct: 1964 YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGF 2023

Query: 214  MENYNIALRWTAKQKLYLRTGESAEFV 240
              NY  +L  T    L +  G   +FV
Sbjct: 2024 PGNYPSSLDCTWTINLPIGFGVHLQFV 2050



 Score = 33.5 bits (75), Expect = 0.20
 Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 14/65 (21%)

Query: 174 VEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPC----------VISREIMENY--NI 219
           + ++CQ  ++L G K I C+ N QWS   P C+ PC          V+S +  E Y  N+
Sbjct: 582 LRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNL 641

Query: 220 ALRWT 224
              WT
Sbjct: 642 NCIWT 646



 Score = 33.1 bits (74), Expect = 0.26
 Identities = 19/63 (30%), Positives = 29/63 (46%), Gaps = 7/63 (11%)

Query: 149  CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCL 204
            C  P P  NG +     +V     ++ ++C   Y L GN  +TC +G    W+ P P+C 
Sbjct: 2120 CPDPRPFRNGFVIGNDFTV---GQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCE 2176

Query: 205  HPC 207
              C
Sbjct: 2177 ALC 2179



 Score = 32.0 bits (71), Expect = 0.59
 Identities = 22/66 (33%), Positives = 34/66 (51%), Gaps = 12/66 (18%)

Query: 107  GDTVQIICNTGYRLQNNENNISCV---ERGWSTP-PKCRSTDSTGKCGPPPPIDNGDITS 162
            GDT+   C++GYRL+   + I C+    R WS P P+C       +CG     + G + S
Sbjct: 1097 GDTLTFSCSSGYRLEGT-SEIICLGGGRRVWSAPLPRC-----VAECGASATNNEGILLS 1150

Query: 163  --FPLS 166
              +PL+
Sbjct: 1151 PNYPLN 1156



 Score = 30.8 bits (68), Expect = 1.3
 Identities = 34/121 (28%), Positives = 46/121 (38%), Gaps = 29/121 (23%)

Query: 61   SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSG----------QTHLEGDTV 110
            S S   W       EG   T +  +L +  F E  H E  G          Q H  G T+
Sbjct: 1218 STSNQLWLEFNSDTEG---TDEGFQLVYTSF-ELSHCEDPGIPQFGYKISDQGHFAGSTI 1273

Query: 111  QIICNTGYRLQNNENNISCV---ERGWSTP-PKCRST-------DSTGKC---GPPPPID 156
               CN GY L +  + + C+    R W  P P C +        +S+G+    G P P D
Sbjct: 1274 IYGCNPGYTL-HGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYD 1332

Query: 157  N 157
            N
Sbjct: 1333 N 1333



 Score = 30.4 bits (67), Expect = 1.7
 Identities = 16/46 (34%), Positives = 20/46 (43%), Gaps = 1/46 (2%)

Query: 96  HSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKC 140
           H    G     G TV   C++GYRL + E  +      WS P P C
Sbjct: 914 HGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 959



 Score = 30.4 bits (67), Expect = 1.7
 Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 4/39 (10%)

Query: 173  SVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCLHPC 207
            ++ + C + Y+LEG   I C  G    WS P P+C+  C
Sbjct: 1099 TLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAEC 1137



 Score = 30.4 bits (67), Expect = 1.7
 Identities = 25/87 (28%), Positives = 32/87 (36%), Gaps = 19/87 (21%)

Query: 149  CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEP------PK 202
            C  P  I NG         Y   S+V Y C   Y L+G   +TC  G    P      P 
Sbjct: 1597 CFDPGNIMNGTRLGMD---YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1653

Query: 203  CLHPC----------VISREIMENYNI 219
            C  PC          V+S    +NY++
Sbjct: 1654 CHAPCGSRSTGSEGTVLSPNYPKNYSV 1680



 Score = 28.9 bits (63), Expect = 5.0
 Identities = 16/46 (34%), Positives = 22/46 (47%), Gaps = 6/46 (13%)

Query: 168  YAPASSVEYQCQNLYQLEGNKRITCRN-----GQWSEP-PKCLHPC 207
            +A  SSV + C   Y L G+  I C        QW++  P C+ PC
Sbjct: 1790 FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPC 1835



 Score = 28.5 bits (62), Expect = 6.5
 Identities = 21/80 (26%), Positives = 35/80 (43%), Gaps = 13/80 (16%)

Query: 117 GYRL---QNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASS 173
           G++L   ++N N  S +  G           ++  C  P   +NG       S+    S+
Sbjct: 354 GFKLFPGKDNSNKFSILNEGGIKT-------ASNLCPDPGEPENGKRIGSDFSL---GST 403

Query: 174 VEYQCQNLYQLEGNKRITCR 193
           V++ C   Y L+G K ITC+
Sbjct: 404 VQFSCDEDYVLQGAKSITCQ 423



 Score = 28.5 bits (62), Expect = 6.5
 Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 5/44 (11%)

Query: 101  GQTHLEGDTVQIICNTGYRLQNNENNISCVE---RGWSTP-PKC 140
            G  ++ GD V   C+ GY LQ + ++I+C+    R W+ P P C
Sbjct: 1961 GDRYMVGDVVSFQCDQGYSLQGH-SHITCMPGPVRRWNYPIPIC 2003



 Score = 28.1 bits (61), Expect = 8.5
 Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 6/46 (13%)

Query: 100  SGQTHLEGDTVQIICNTGYRLQNNENNISCVE----RGWS-TPPKC 140
            +G     GDTV   C+ GY LQ  E  I+C++      W  +PP C
Sbjct: 1436 NGDGREPGDTVVFQCDPGYELQ-GEERITCIQVENRYFWQPSPPVC 1480


>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
          Length = 3707

 Score = 58.5 bits (140), Expect = 6e-09
 Identities = 71/234 (30%), Positives = 100/234 (42%), Gaps = 34/234 (14%)

Query: 48   GEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS-PTPKCLRL-CFFPFVENGHSESSGQTH 104
            G V +Y C   +     S    + C   G W  P P+C+ + C  P V   ++  SG+ +
Sbjct: 2956 GTVVFYDCNPGYFLFGSSV---LICQPNGQWDKPLPECIMIDCGHPGVPP-NAVLSGEKY 3011

Query: 105  LEGDTVQIICNTGYRLQNNENNISCVERG-WS-TPPKCRSTDSTGKCGPPPPIDNGDITS 162
              G TV   C TG R    +++ +C   G WS + P C S D+TG CG P    +G   S
Sbjct: 3012 TFGSTVHYSC-TGKRSLLGQSSRTCQLNGHWSGSQPHC-SGDATGTCGDPGTPGHG---S 3066

Query: 163  FPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWS-EPPKCLHPCVISREIMENYNIA 220
               S +   S+V Y C   Y L G++  TC  NG W+   P+C        + ++  N  
Sbjct: 3067 RQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC--------KAVQCGNPG 3118

Query: 221  LRWTAKQKLYLRTG----ESAEFVCKRGYRLSSRSHTLRTT--CWDGKLEYPTC 268
               TA  K++   G     S  + C  GY LS  S    T    W G L  P C
Sbjct: 3119 T--TANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTL--PNC 3168



 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 68/261 (26%), Positives = 96/261 (36%), Gaps = 42/261 (16%)

Query: 23   CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSC--EYNFVSPSKSFWTRITCTEEG-WSP 79
            C  P +    +   EKY        G   +YSC  + + +  S       TC   G WS 
Sbjct: 2995 CGHPGVPPNAVLSGEKYT------FGSTVHYSCTGKRSLLGQSSR-----TCQLNGHWSG 3043

Query: 80   T-PKC----LRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
            + P C       C  P    GH            TV+  C+TGY L  +E         W
Sbjct: 3044 SQPHCSGDATGTCGDPGTP-GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSW 3102

Query: 135  S-TPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR 193
            +   P+C++     +CG P    NG +  F +     +SSV Y C   Y L G     C 
Sbjct: 3103 TGRQPECKAV----QCGNPGTTANGKV--FRIDGTTFSSSVIYSCMEGYILSGPSVRQCT 3156

Query: 194  -NGQWSEP-PKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRS 251
             NG WS   P C         I  N    LR+     +    G++  ++C+ GY +    
Sbjct: 3157 ANGTWSGTLPNCTIISCGDPGIPAN---GLRYGDDYVV----GQNVSYMCQPGYTMELNG 3209

Query: 252  HTLRTT----CWDGKLEYPTC 268
              +RT      W G +  PTC
Sbjct: 3210 SRIRTCTINGTWSGVM--PTC 3228



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 54/215 (25%), Positives = 82/215 (38%), Gaps = 23/215 (10%)

Query: 53   YSCEYNFVSPSKSFWTRITCTEEGWS-PTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQ 111
            Y C   F     S   RI   +  WS   P C+ +         +  +SG      D V 
Sbjct: 2841 YQCNPGFRLIGSS--VRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVT 2898

Query: 112  IICNTGYRLQNNENNISCVERGWS-TPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAP 170
              CN GY +Q          R WS  PP C+  + +    P  P ++   +      +  
Sbjct: 2899 FSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCS---DPGIPANSKRESKIEHGNFTY 2955

Query: 171  ASSVEYQCQNLYQLEGNKRITCR-NGQWSEP-PKCL-----HPCVISREIM--ENY---- 217
             + V Y C   Y L G+  + C+ NGQW +P P+C+     HP V    ++  E Y    
Sbjct: 2956 GTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGS 3015

Query: 218  NIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSH 252
             +    T K+ L    G+S+      G+   S+ H
Sbjct: 3016 TVHYSCTGKRSL---LGQSSRTCQLNGHWSGSQPH 3047



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 43/165 (26%), Positives = 66/165 (40%), Gaps = 18/165 (10%)

Query: 43   SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPTP-KCLR-LCFFP-FVENGHSE 98
            +Q   G    ++C+  F+    +      C   G WS +  +CL   C  P  + NG  +
Sbjct: 2773 TQTSYGSTAIFTCDLGFMLVGSAVRE---CLSSGLWSESETRCLAGHCGIPELIVNG--Q 2827

Query: 99   SSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTDSTGKCGPPPPIDN 157
              G+ +   DTV   CN G+RL  +   I   +  WS   P C        CG P     
Sbjct: 2828 VIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV----SCGHPGSPIY 2883

Query: 158  GDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWSEPP 201
            G  +    + +     V + C   Y ++G  +  C+ N QWS PP
Sbjct: 2884 GRTSG---NGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPP 2925



 Score = 38.1 bits (87), Expect = 0.008
 Identities = 22/77 (28%), Positives = 36/77 (46%), Gaps = 5/77 (6%)

Query: 149  CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSE----PPKCL 204
            C PPPP+ N +I +     +     + YQC   + L GN  +TCR G+  +    PP C 
Sbjct: 2395 CQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2453

Query: 205  HPCVISREIMENYNIAL 221
              C  +   +++  + L
Sbjct: 2454 VLCPANELRLDSTGVIL 2470



 Score = 36.6 bits (83), Expect = 0.024
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 5/43 (11%)

Query: 170  PASSVEYQCQNLYQLEGNKRITCRNGQ----WS-EPPKCLHPC 207
            P  +V +QC   Y+L+G +RITC   +    W   PP C+ PC
Sbjct: 1546 PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1588



 Score = 33.9 bits (76), Expect = 0.15
 Identities = 26/87 (29%), Positives = 36/87 (41%), Gaps = 14/87 (16%)

Query: 168  YAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCLHPC----------VISREI 213
            Y     V +QC   Y L+G+  ITC  G   +W+ P P CL  C          ++S   
Sbjct: 2068 YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGF 2127

Query: 214  MENYNIALRWTAKQKLYLRTGESAEFV 240
              NY  +L  T    L +  G   +FV
Sbjct: 2128 PGNYPSSLDCTWTINLPIGFGVHLQFV 2154



 Score = 33.5 bits (75), Expect = 0.20
 Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 14/65 (21%)

Query: 174 VEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPC----------VISREIMENY--NI 219
           + ++CQ  ++L G K I C+ N QWS   P C+ PC          V+S +  E Y  N+
Sbjct: 686 LRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNL 745

Query: 220 ALRWT 224
              WT
Sbjct: 746 NCIWT 750



 Score = 33.1 bits (74), Expect = 0.26
 Identities = 19/63 (30%), Positives = 29/63 (46%), Gaps = 7/63 (11%)

Query: 149  CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCL 204
            C  P P  NG +     +V     ++ ++C   Y L GN  +TC +G    W+ P P+C 
Sbjct: 2224 CPDPRPFRNGFVIGNDFTV---GQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCE 2280

Query: 205  HPC 207
              C
Sbjct: 2281 ALC 2283



 Score = 32.0 bits (71), Expect = 0.59
 Identities = 22/66 (33%), Positives = 34/66 (51%), Gaps = 12/66 (18%)

Query: 107  GDTVQIICNTGYRLQNNENNISCV---ERGWSTP-PKCRSTDSTGKCGPPPPIDNGDITS 162
            GDT+   C++GYRL+   + I C+    R WS P P+C       +CG     + G + S
Sbjct: 1201 GDTLTFSCSSGYRLEGT-SEIICLGGGRRVWSAPLPRC-----VAECGASATNNEGILLS 1254

Query: 163  --FPLS 166
              +PL+
Sbjct: 1255 PNYPLN 1260



 Score = 30.8 bits (68), Expect = 1.3
 Identities = 34/121 (28%), Positives = 46/121 (38%), Gaps = 29/121 (23%)

Query: 61   SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSG----------QTHLEGDTV 110
            S S   W       EG   T +  +L +  F E  H E  G          Q H  G T+
Sbjct: 1322 STSNQLWLEFNSDTEG---TDEGFQLVYTSF-ELSHCEDPGIPQFGYKISDQGHFAGSTI 1377

Query: 111  QIICNTGYRLQNNENNISCV---ERGWSTP-PKCRST-------DSTGKC---GPPPPID 156
               CN GY L +  + + C+    R W  P P C +        +S+G+    G P P D
Sbjct: 1378 IYGCNPGYTL-HGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYD 1436

Query: 157  N 157
            N
Sbjct: 1437 N 1437



 Score = 30.4 bits (67), Expect = 1.7
 Identities = 16/46 (34%), Positives = 20/46 (43%), Gaps = 1/46 (2%)

Query: 96   HSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKC 140
            H    G     G TV   C++GYRL + E  +      WS P P C
Sbjct: 1018 HGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1063



 Score = 30.4 bits (67), Expect = 1.7
 Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 4/39 (10%)

Query: 173  SVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCLHPC 207
            ++ + C + Y+LEG   I C  G    WS P P+C+  C
Sbjct: 1203 TLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAEC 1241



 Score = 30.4 bits (67), Expect = 1.7
 Identities = 25/87 (28%), Positives = 32/87 (36%), Gaps = 19/87 (21%)

Query: 149  CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEP------PK 202
            C  P  I NG         Y   S+V Y C   Y L+G   +TC  G    P      P 
Sbjct: 1701 CFDPGNIMNGTRLGMD---YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1757

Query: 203  CLHPC----------VISREIMENYNI 219
            C  PC          V+S    +NY++
Sbjct: 1758 CHAPCGSRSTGSEGTVLSPNYPKNYSV 1784



 Score = 30.4 bits (67), Expect = 1.7
 Identities = 49/175 (28%), Positives = 65/175 (37%), Gaps = 32/175 (18%)

Query: 50   VFYYSCEYNF--VSPSKSFWTRITCTEEGW-SPTPKCLRL-CFFPFVE-NGHSESSGQTH 104
            V  ++C+  F  V  S +   + +     W +P P C  + C  P    NG   ++   +
Sbjct: 2591 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTD--Y 2648

Query: 105  LEGDTVQIICNTGYRLQNNE-NNISCVERG-WSTPPKCRSTDSTGKCGPPPPIDNGDITS 162
            L G  V   CN GYRL + E     C   G WS   K      T +C     +    I S
Sbjct: 2649 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNK------TPRC---VVVTCPSINS 2699

Query: 163  FPL----------SVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWS---EPPKC 203
            F L          S Y   + V + C   Y   G   I C  NG WS   E P C
Sbjct: 2700 FILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYC 2754



 Score = 28.9 bits (63), Expect = 5.0
 Identities = 16/46 (34%), Positives = 22/46 (47%), Gaps = 6/46 (13%)

Query: 168  YAPASSVEYQCQNLYQLEGNKRITCRN-----GQWSEP-PKCLHPC 207
            +A  SSV + C   Y L G+  I C        QW++  P C+ PC
Sbjct: 1894 FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPC 1939



 Score = 28.5 bits (62), Expect = 6.5
 Identities = 21/80 (26%), Positives = 35/80 (43%), Gaps = 13/80 (16%)

Query: 117 GYRL---QNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASS 173
           G++L   ++N N  S +  G           ++  C  P   +NG       S+    S+
Sbjct: 458 GFKLFPGKDNSNKFSILNEGGIKT-------ASNLCPDPGEPENGKRIGSDFSL---GST 507

Query: 174 VEYQCQNLYQLEGNKRITCR 193
           V++ C   Y L+G K ITC+
Sbjct: 508 VQFSCDEDYVLQGAKSITCQ 527



 Score = 28.5 bits (62), Expect = 6.5
 Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 5/44 (11%)

Query: 101  GQTHLEGDTVQIICNTGYRLQNNENNISCVE---RGWSTP-PKC 140
            G  ++ GD V   C+ GY LQ + ++I+C+    R W+ P P C
Sbjct: 2065 GDRYMVGDVVSFQCDQGYSLQGH-SHITCMPGPVRRWNYPIPIC 2107



 Score = 28.1 bits (61), Expect = 8.5
 Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 6/46 (13%)

Query: 100  SGQTHLEGDTVQIICNTGYRLQNNENNISCVE----RGWS-TPPKC 140
            +G     GDTV   C+ GY LQ  E  I+C++      W  +PP C
Sbjct: 1540 NGDGREPGDTVVFQCDPGYELQ-GEERITCIQVENRYFWQPSPPVC 1584


>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
          Length = 3565

 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 53/175 (30%), Positives = 73/175 (41%), Gaps = 21/175 (12%)

Query: 53   YSCEYNFVSPSKSFWTRITCTEEGWS-PTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQ 111
            Y C   F     S   RI   +  WS  TP C+ +         H  ++G      D V 
Sbjct: 2705 YQCNPGFRLVGTS--VRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGSEFNLNDVVN 2762

Query: 112  IICNTGYRLQNNENNISCVERG-WSTP-PKCRSTDSTGKCGPPPPIDNG---DITSFPLS 166
              CNTGY LQ   +   C   G WS+P P CR  +    C  P  ++N       +FP S
Sbjct: 2763 FTCNTGYLLQ-GVSRAQCRSNGQWSSPLPTCRVVN----CSDPGFVENAIRHGQQNFPES 2817

Query: 167  VYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEP-PKCL-----HPCVISREIM 214
             +    S+ Y C+  + L G+  +TC  NG W    PKCL     HP V +  ++
Sbjct: 2818 -FEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVL 2871



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 61/219 (27%), Positives = 86/219 (39%), Gaps = 41/219 (18%)

Query: 67   WTRITCTEEG-WS-----PTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
            W  + C   G W+     P+ + +      F  NG+    G   + G T    CNTGY L
Sbjct: 2598 WRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNK--IGTLTVYGATAIFTCNTGYTL 2655

Query: 121  QNNENNISCVERG-WS-TPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQC 178
              +     C+  G WS +  +C +    G CG P PI NG I+      ++   +V YQC
Sbjct: 2656 VGSHVR-ECLANGLWSGSETRCLA----GHCGSPDPIVNGHISG---DGFSYRDTVVYQC 2707

Query: 179  QNLYQLEGNK-RITCRNGQWS------EPPKCLHPCVISREIMENYNIALRWTAKQKLYL 231
               ++L G   RI  ++ +WS       P  C HP           N A  +T   +  L
Sbjct: 2708 NPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHP----------GNPAHGFTNGSEFNL 2757

Query: 232  RTGESAEFVCKRGYRLS--SRSHTLRTTCWDGKLEYPTC 268
               +   F C  GY L   SR+       W   L  PTC
Sbjct: 2758 --NDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPL--PTC 2792



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 55/183 (30%), Positives = 71/183 (38%), Gaps = 20/183 (10%)

Query: 92   VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWS-TPPKCRSTDSTGKCG 150
            + NGH    G ++   DTV   CN G+RL      I   +  WS   P C          
Sbjct: 2687 IVNGHISGDGFSYR--DTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGN 2744

Query: 151  PPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWSEP-PKCLHPCV 208
            P     NG  + F L+       V + C   Y L+G  R  CR NGQWS P P C     
Sbjct: 2745 PAHGFTNG--SEFNLN-----DVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNC 2797

Query: 209  ISREIMENYNIALRWTAKQ-KLYLRTGESAEFVCKRGYRL--SSRSHTLRTTCWDGKLEY 265
                 +EN   A+R   +        G S  + CK+G+ L  SS    +    WD  L  
Sbjct: 2798 SDPGFVEN---AIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSL-- 2852

Query: 266  PTC 268
            P C
Sbjct: 2853 PKC 2855



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 33/101 (32%), Positives = 47/101 (46%), Gaps = 12/101 (11%)

Query: 109  TVQIICNTGYRLQN-NENNISCVERGWSTP--PKCRSTDSTGKCGPPPPIDNGDITSFPL 165
            TV   CN GY ++      I C + G   P  P C++      C  PPP+ NG +     
Sbjct: 3059 TVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAV----LCPQPPPVQNGTVEG--- 3111

Query: 166  SVYAPASSVEYQCQNLYQLEGNKRITCR-NGQW-SEPPKCL 204
            S +   SS+ Y C + YQL  +  ++C   G W  E P+CL
Sbjct: 3112 SDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCL 3152



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 42/156 (26%), Positives = 62/156 (39%), Gaps = 13/156 (8%)

Query: 48   GEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPT-PKCLRL-CFFPFVENGHSESSGQTH 104
            G    Y C+  F     S    +TC   G W  + PKCL + C  P V   ++  +G+  
Sbjct: 2821 GMSILYHCKKGFYLLGSS---ALTCMANGLWDRSLPKCLAISCGHPGVP-ANAVLTGELF 2876

Query: 105  LEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTDSTGKCGPPPPIDNGDITSF 163
              G  V   C     L  N+  +   +  WS   P C   ++ G CG P    +G     
Sbjct: 2877 TYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTG-NNPGFCGDPGTPAHGSRLG- 2934

Query: 164  PLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWS 198
                +   S + + C+  +QL G+   TC  NG WS
Sbjct: 2935 --DDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWS 2968



 Score = 41.6 bits (96), Expect = 7e-04
 Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 7/63 (11%)

Query: 149  CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCL 204
            C  PPP  NG + +   S Y+   SV ++C   Y L G+  +TC++G    W+ P P+C 
Sbjct: 2088 CPDPPPFQNGYMIN---SDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCD 2144

Query: 205  HPC 207
             PC
Sbjct: 2145 APC 2147



 Score = 33.5 bits (75), Expect = 0.20
 Identities = 20/63 (31%), Positives = 30/63 (47%), Gaps = 5/63 (7%)

Query: 147 GKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWS-EPPKCL 204
           G CG P     G  T    S +    ++ ++C   ++L G + ITC +N QWS   P C+
Sbjct: 526 GGCGDPGIPAYGKRTG---SSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCV 582

Query: 205 HPC 207
             C
Sbjct: 583 FSC 585



 Score = 32.7 bits (73), Expect = 0.34
 Identities = 24/71 (33%), Positives = 31/71 (43%), Gaps = 8/71 (11%)

Query: 142  STDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-----RNGQ 196
            ST     C  P    NG  T +  S  A   +V +QC   YQL+G  +ITC     R   
Sbjct: 1385 STSIAATCNDPGMPQNG--TRYGDSREA-GDTVTFQCDPGYQLQGQAKITCVQLNNRFFW 1441

Query: 197  WSEPPKCLHPC 207
              +PP C+  C
Sbjct: 1442 QPDPPTCIAAC 1452



 Score = 32.0 bits (71), Expect = 0.59
 Identities = 18/61 (29%), Positives = 30/61 (49%), Gaps = 7/61 (11%)

Query: 154  PIDNGDITSFPLSV---YAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCLHP 206
            P D+  + +F   +   +    S+ + C   Y+LEG  ++TC  G    WS P P+C+  
Sbjct: 1045 PCDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVAE 1104

Query: 207  C 207
            C
Sbjct: 1105 C 1105



 Score = 31.6 bits (70), Expect = 0.77
 Identities = 35/132 (26%), Positives = 48/132 (36%), Gaps = 23/132 (17%)

Query: 149  CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNG-----QW-SEPPK 202
            C    P+ NG I +   +  A  S V Y C+  Y++ G+   TCR       QW S  P 
Sbjct: 2433 CSLTHPLKNGGILN--RTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPL 2490

Query: 203  C-LHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTC--- 258
            C    C I             +T   K+         + C  G++L S S      C   
Sbjct: 2491 CQAVSCGIPESPGNGSFTGNEFTLDSKVV--------YECHEGFKLES-SQQATAVCQED 2541

Query: 259  --WDGKLEYPTC 268
              W  K + PTC
Sbjct: 2542 GLWSNKGKPPTC 2553



 Score = 30.0 bits (66), Expect = 2.2
 Identities = 19/56 (33%), Positives = 26/56 (46%), Gaps = 6/56 (10%)

Query: 101  GQTHLEGDTVQIICNTGYRLQNNENNISCVERG----WS-TPPKCRSTDSTGKCGP 151
            G +   GDTV   C+ GY+LQ  +  I+CV+      W   PP C +       GP
Sbjct: 1405 GDSREAGDTVTFQCDPGYQLQ-GQAKITCVQLNNRFFWQPDPPTCIAACGGNLTGP 1459



 Score = 30.0 bits (66), Expect = 2.2
 Identities = 14/48 (29%), Positives = 26/48 (54%), Gaps = 6/48 (12%)

Query: 166  SVYAPASSVEYQCQNLYQLEGNKRITCRN-----GQWSEP-PKCLHPC 207
            S ++  S V ++C   Y L+G+  + C++      QW++  P C+ PC
Sbjct: 1756 SEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCVVPC 1803



 Score = 29.3 bits (64), Expect = 3.8
 Identities = 34/161 (21%), Positives = 63/161 (39%), Gaps = 17/161 (10%)

Query: 52   YYSCEYNFVSPSKSFWTRITCTEEG-WSPT-PKCL----RLCFFPFVENGHSESSGQTHL 105
            ++ C+  F+    S   R  C  +G WS   P C+      C  P   +   ++S + + 
Sbjct: 3179 FFQCKSPFILVGSS---RRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRGYE 3235

Query: 106  EGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPL 165
             G TV   C  GY +Q +          WS     ++      C  P    + D+ +  L
Sbjct: 3236 VGSTVFFRCRKGYHIQGSTTRTCLANLTWS---GIQTECIPHACRQPETPAHADVRAIDL 3292

Query: 166  SVYAPASSVEYQCQ-NLYQLEGNKRITCR-NGQWS-EPPKC 203
              +    ++ Y C    +   G++  TC+ + +W+ + P C
Sbjct: 3293 PTF--GYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVC 3331



 Score = 28.9 bits (63), Expect = 5.0
 Identities = 13/38 (34%), Positives = 19/38 (50%), Gaps = 4/38 (10%)

Query: 174  VEYQCQNLYQLEGNKRITCRNGQ---WSEP-PKCLHPC 207
            V Y C   Y + G+  +TC +G    W +P P C+  C
Sbjct: 1241 VLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIAEC 1278



 Score = 28.9 bits (63), Expect = 5.0
 Identities = 13/38 (34%), Positives = 21/38 (55%), Gaps = 4/38 (10%)

Query: 174  VEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCLHPC 207
            + +QC+  Y L+G   I+C  G   +W+ P P C+  C
Sbjct: 1938 LSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIATC 1975



 Score = 28.9 bits (63), Expect = 5.0
 Identities = 14/46 (30%), Positives = 22/46 (47%), Gaps = 1/46 (2%)

Query: 148  KCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR 193
            KC PPP +   ++ +     +     V+YQC   Y L G   +TC+
Sbjct: 2258 KCQPPPAVPQAEMLTED-DDFEIGDFVKYQCHPGYTLVGTDILTCK 2302



 Score = 28.1 bits (61), Expect = 8.5
 Identities = 9/22 (40%), Positives = 18/22 (81%)

Query: 172 SSVEYQCQNLYQLEGNKRITCR 193
           ++V++ C++ Y L+G+K ITC+
Sbjct: 370 ANVQFSCEDNYVLQGSKSITCQ 391



 Score = 28.1 bits (61), Expect = 8.5
 Identities = 22/67 (32%), Positives = 28/67 (41%), Gaps = 13/67 (19%)

Query: 149  CGPPPPIDNGDI--TSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEP------ 200
            C  P  I NG    T F L      S++ YQC + Y++     ITC  G   +P      
Sbjct: 1565 CFDPGNIMNGTRVGTDFKLG-----STITYQCDSGYKILDPSSITCVIGADGKPSWDQVL 1619

Query: 201  PKCLHPC 207
            P C  PC
Sbjct: 1620 PSCNAPC 1626


>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
           sapiens]
          Length = 569

 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 62/256 (24%), Positives = 95/256 (37%), Gaps = 51/256 (19%)

Query: 44  QVPTGEVFYYSCE-------YNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGH 96
           + P G    Y C        ++ +    S WT         S   KC R        N  
Sbjct: 54  EFPIGTYLNYECRPGYSGRPFSIICLKNSVWT---------SAKDKCKRKS----CRNPP 100

Query: 97  SESSGQTHLEGDT-----VQIICNTGYRLQNNENNISCVERG----WSTP-PKCRSTDST 146
              +G  H+  D      ++  C  GYRL  + ++ +C+  G    W    P C      
Sbjct: 101 DPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGS-SSATCIISGNTVIWDNKTPVCDRII-- 157

Query: 147 GKCGPPPPIDNGDITSFPLSVYAPASSVEYQC------QNLYQLEGNKRITCRN-----G 195
             CG PP I NGD TS     +   S V Y C      + +++L G   I C +     G
Sbjct: 158 --CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVG 215

Query: 196 QWSEP-PKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTL 254
            WS P P+C+ P   +   +EN  +     +  +      E  EF C+ G+ +   SH  
Sbjct: 216 IWSGPAPQCIIPNKCTPPNVENGIL----VSDNRSLFSLNEVVEFRCQPGFGMKGPSHVK 271

Query: 255 RTTCWDGKLEYPTCAK 270
                  + E P+C++
Sbjct: 272 CQALNKWEPELPSCSR 287



 Score = 55.1 bits (131), Expect = 6e-08
 Identities = 58/223 (26%), Positives = 89/223 (39%), Gaps = 33/223 (14%)

Query: 48  GEVFYYSCEYNFVSPSKSFWT-----RITCTEEG-----WS-PTPKCL--RLCFFPFVEN 94
           G V  Y C  N  S  K  +       I CT +      WS P P+C+    C  P VEN
Sbjct: 180 GSVVTYHC--NLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVEN 237

Query: 95  GHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERGWSTP--PKCRSTDSTGKCGP 151
           G   S  ++     + V+  C  G+ ++   +++ C       P  P C        C P
Sbjct: 238 GILVSDNRSLFSLNEVVEFRCQPGFGMKG-PSHVKCQALNKWEPELPSCSRV-----CQP 291

Query: 152 PPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC-LHPCV 208
           PP + + + T      ++P   V Y C+  Y L G+  + C   G WS   P+C +  C 
Sbjct: 292 PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCD 351

Query: 209 ISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRS 251
                + N ++         L L+ G   +FVC  G++L   S
Sbjct: 352 DFLGQLPNGHVLF------PLNLQLGAKVDFVCDEGFQLKGSS 388



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 55/195 (28%), Positives = 73/195 (37%), Gaps = 38/195 (19%)

Query: 44  QVPTGEVFY-----------YSCEYNF-VSPSKSFWTRITCTEEGW-SPTPKCLRL-CFF 89
           Q+P G V +           + C+  F +  S + +  +   E  W S  P C R  C  
Sbjct: 356 QLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCET 415

Query: 90  PFVE-NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----WST-PPKCRST 143
           P V  NG        H+ G  +   C TG+RL  + ++  C+  G    WS  PP C+  
Sbjct: 416 PPVPVNGMVHVITDIHV-GSRINYSCTTGHRLIGH-SSAECILSGNTAHWSMKPPICQQI 473

Query: 144 DSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGNKRITCR---- 193
                C  PP I NG  T  PL        V Y C         + L G   I       
Sbjct: 474 F----CPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPH 529

Query: 194 -NGQWSEP-PKCLHP 206
            NG WS P P+C  P
Sbjct: 530 GNGVWSSPAPRCELP 544


>gi|62912468 complement component 4 binding protein, beta chain
           isoform 1 precursor [Homo sapiens]
          Length = 252

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 39/131 (29%), Positives = 60/131 (45%), Gaps = 12/131 (9%)

Query: 77  WSPTPKCLRL--CFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
           W  T    RL  C  P + NG   SSG  ++  D +  +CN  Y L+ +  +    +  W
Sbjct: 69  WDNTTTECRLGHCPDPVLVNGEFSSSGPVNVS-DKITFMCNDHYILKGSNRSQCLEDHTW 127

Query: 135 STP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR 193
           + P P C+S D    C PP    +G    F  + +   S++ Y C++ Y L G +   C 
Sbjct: 128 APPFPICKSRD----CDPPGNPVHG---YFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV 180

Query: 194 NGQWSEP-PKC 203
           +G+WS   P C
Sbjct: 181 DGEWSSALPVC 191


>gi|62912466 complement component 4 binding protein, beta chain
           isoform 2 precursor [Homo sapiens]
          Length = 251

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 39/131 (29%), Positives = 60/131 (45%), Gaps = 12/131 (9%)

Query: 77  WSPTPKCLRL--CFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
           W  T    RL  C  P + NG   SSG  ++  D +  +CN  Y L+ +  +    +  W
Sbjct: 68  WDNTTTECRLGHCPDPVLVNGEFSSSGPVNVS-DKITFMCNDHYILKGSNRSQCLEDHTW 126

Query: 135 STP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR 193
           + P P C+S D    C PP    +G    F  + +   S++ Y C++ Y L G +   C 
Sbjct: 127 APPFPICKSRD----CDPPGNPVHG---YFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV 179

Query: 194 NGQWSEP-PKC 203
           +G+WS   P C
Sbjct: 180 DGEWSSALPVC 190


>gi|62912464 complement component 4 binding protein, beta chain
           isoform 1 precursor [Homo sapiens]
          Length = 252

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 39/131 (29%), Positives = 60/131 (45%), Gaps = 12/131 (9%)

Query: 77  WSPTPKCLRL--CFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
           W  T    RL  C  P + NG   SSG  ++  D +  +CN  Y L+ +  +    +  W
Sbjct: 69  WDNTTTECRLGHCPDPVLVNGEFSSSGPVNVS-DKITFMCNDHYILKGSNRSQCLEDHTW 127

Query: 135 STP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR 193
           + P P C+S D    C PP    +G    F  + +   S++ Y C++ Y L G +   C 
Sbjct: 128 APPFPICKSRD----CDPPGNPVHG---YFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV 180

Query: 194 NGQWSEP-PKC 203
           +G+WS   P C
Sbjct: 181 DGEWSSALPVC 191


>gi|62912462 complement component 4 binding protein, beta chain
           isoform 2 precursor [Homo sapiens]
          Length = 251

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 39/131 (29%), Positives = 60/131 (45%), Gaps = 12/131 (9%)

Query: 77  WSPTPKCLRL--CFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
           W  T    RL  C  P + NG   SSG  ++  D +  +CN  Y L+ +  +    +  W
Sbjct: 68  WDNTTTECRLGHCPDPVLVNGEFSSSGPVNVS-DKITFMCNDHYILKGSNRSQCLEDHTW 126

Query: 135 STP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR 193
           + P P C+S D    C PP    +G    F  + +   S++ Y C++ Y L G +   C 
Sbjct: 127 APPFPICKSRD----CDPPGNPVHG---YFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV 179

Query: 194 NGQWSEP-PKC 203
           +G+WS   P C
Sbjct: 180 DGEWSSALPVC 190


>gi|4502505 complement component 4 binding protein, beta chain
           isoform 1 precursor [Homo sapiens]
          Length = 252

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 39/131 (29%), Positives = 60/131 (45%), Gaps = 12/131 (9%)

Query: 77  WSPTPKCLRL--CFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
           W  T    RL  C  P + NG   SSG  ++  D +  +CN  Y L+ +  +    +  W
Sbjct: 69  WDNTTTECRLGHCPDPVLVNGEFSSSGPVNVS-DKITFMCNDHYILKGSNRSQCLEDHTW 127

Query: 135 STP-PKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR 193
           + P P C+S D    C PP    +G    F  + +   S++ Y C++ Y L G +   C 
Sbjct: 128 APPFPICKSRD----CDPPGNPVHG---YFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV 180

Query: 194 NGQWSEP-PKC 203
           +G+WS   P C
Sbjct: 181 DGEWSSALPVC 191


>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
           precursor [Homo sapiens]
          Length = 373

 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 70/261 (26%), Positives = 102/261 (39%), Gaps = 52/261 (19%)

Query: 38  KYKPFSQVPTGEVFYYSCE--YNFVSPSKSFWTRITCTEEGWSPTPK--CLR-LCFFPFV 92
           K KP+ ++  GE   Y C+  Y ++ P  +    I      W P     C R  C  P++
Sbjct: 49  KPKPYYEI--GERVDYKCKKGYFYIPPLATH--TICDRNHTWLPVSDDACYRETC--PYI 102

Query: 93  E---NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----WS-TPPKCRSTD 144
               NG +  +  T+  G  +  ICN GY L   E  + C  +G    WS  PP C    
Sbjct: 103 RDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEI-LYCELKGSVAIWSGKPPICEKV- 160

Query: 145 STGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC-RNGQWS 198
               C PPP I NG  T   + V+    +V Y C      + + L G   I C  N  WS
Sbjct: 161 ---LCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWS 217

Query: 199 EPP------KCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSH 252
                    KC  P V + + +  +         +K Y +   +  F C +G+ L   S 
Sbjct: 218 RAAPECKVVKCRFPVVENGKQISGFG--------KKFYYKA--TVMFECDKGFYLDG-SD 266

Query: 253 TL---RTTCWDGKLEYPTCAK 270
           T+     + WD  +  P C K
Sbjct: 267 TIVCDSNSTWDPPV--PKCLK 285


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.448 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,182,646
Number of Sequences: 37866
Number of extensions: 675969
Number of successful extensions: 2276
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 49
Number of HSP's that attempted gapping in prelim test: 1592
Number of HSP's gapped (non-prelim): 417
length of query: 271
length of database: 18,247,518
effective HSP length: 101
effective length of query: 170
effective length of database: 14,423,052
effective search space: 2451918840
effective search space used: 2451918840
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.