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Search of human proteins with 239758113
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239758113 PREDICTED: similar to complement factor H-related
1 isoform 1 [Homo sapiens]
(330 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118442839 complement factor H-related 1 [Homo sapiens] 715 0.0
gi|239758113 PREDICTED: similar to complement factor H-related 1... 715 0.0
gi|62739186 complement factor H isoform a precursor [Homo sapiens] 431 e-121
gi|239758115 PREDICTED: similar to complement factor H-related 1... 363 e-100
gi|5031695 H factor (complement)-like 3 [Homo sapiens] 357 6e-99
gi|13540563 complement factor H-related 5 [Homo sapiens] 331 6e-91
gi|54792787 complement factor H-related 3 [Homo sapiens] 304 6e-83
gi|117320518 complement factor H-related 4 [Homo sapiens] 268 5e-72
gi|110611237 coagulation factor XIII B subunit precursor [Homo s... 171 1e-42
gi|62739188 complement factor H isoform b precursor [Homo sapiens] 130 2e-30
gi|153266841 apolipoprotein H precursor [Homo sapiens] 91 1e-18
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 87 3e-17
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 87 3e-17
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 85 8e-17
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 85 8e-17
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 85 8e-17
gi|148886654 polydom [Homo sapiens] 80 2e-15
gi|42544177 complement component (3d/Epstein Barr virus) recepto... 78 1e-14
gi|54792123 complement component (3d/Epstein Barr virus) recepto... 78 1e-14
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 76 4e-14
gi|4502503 complement component 4 binding protein, alpha chain p... 75 8e-14
gi|168693643 decay accelerating factor for complement isoform 2 ... 71 1e-12
gi|10835143 decay accelerating factor for complement isoform 1 p... 71 1e-12
gi|187960042 selectin E precursor [Homo sapiens] 69 6e-12
gi|27502421 CD46 antigen, complement regulatory protein isoform ... 65 6e-11
gi|27502419 CD46 antigen, complement regulatory protein isoform ... 65 6e-11
gi|27502417 CD46 antigen, complement regulatory protein isoform ... 65 6e-11
gi|27502415 CD46 antigen, complement regulatory protein isoform ... 65 6e-11
gi|27502413 CD46 antigen, complement regulatory protein isoform ... 65 6e-11
gi|27502411 CD46 antigen, complement regulatory protein isoform ... 65 6e-11
>gi|118442839 complement factor H-related 1 [Homo sapiens]
Length = 330
Score = 715 bits (1845), Expect = 0.0
Identities = 330/330 (100%), Positives = 330/330 (100%)
Query: 1 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
Sbjct: 1 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
Query: 61 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
Sbjct: 61 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
Query: 121 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180
QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180
Query: 181 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 240
EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL
Sbjct: 181 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 240
Query: 241 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC 300
YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC
Sbjct: 241 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC 300
Query: 301 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 330
KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
Sbjct: 301 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 330
>gi|239758113 PREDICTED: similar to complement factor H-related 1
isoform 1 [Homo sapiens]
Length = 330
Score = 715 bits (1845), Expect = 0.0
Identities = 330/330 (100%), Positives = 330/330 (100%)
Query: 1 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
Sbjct: 1 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
Query: 61 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
Sbjct: 61 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
Query: 121 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180
QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180
Query: 181 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 240
EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL
Sbjct: 181 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 240
Query: 241 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC 300
YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC
Sbjct: 241 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC 300
Query: 301 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 330
KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
Sbjct: 301 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 330
>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
Length = 1231
Score = 431 bits (1107), Expect = e-121
Identities = 213/309 (68%), Positives = 237/309 (76%), Gaps = 16/309 (5%)
Query: 26 PKINHGIL-YDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL 84
P+I+HG++ + + Y+ GE Y C F + C E WS P C+
Sbjct: 935 PEISHGVVAHMSDSYQ------YGEEVTYKCFEGFGIDGPAI---AKCLGEKWSHPPSCI 985
Query: 85 RL-CF-FPFVENGHSESSGQ-THLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCR 141
+ C P EN + + G+ V C T Y++ + +N++C+ W+ P CR
Sbjct: 986 KTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKM-DGASNVTCINSRWTGRPTCR 1044
Query: 142 STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQC 201
DTSCVNPPTVQNA+I+SRQMSKYPSGERVRY+CRSPYEMFGDEEVMCLNGNWTEPPQC
Sbjct: 1045 --DTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGNWTEPPQC 1102
Query: 202 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPK 261
KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPK
Sbjct: 1103 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPK 1162
Query: 262 CLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGK 321
CLHPCVISREIMENYNIALRWTAKQKLY RTGES EFVCKRGYRLSSRSHTLRTTCWDGK
Sbjct: 1163 CLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGK 1222
Query: 322 LEYPTCAKR 330
LEYPTCAKR
Sbjct: 1223 LEYPTCAKR 1231
Score = 161 bits (408), Expect = 7e-40
Identities = 89/294 (30%), Positives = 147/294 (50%), Gaps = 25/294 (8%)
Query: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
CD+P I HG LY E +P+ V G+ + Y C+ +F +PS S+W I CT++GWSP
Sbjct: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384
Query: 83 CLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRS 142
CLR C+FP++ENG++++ G+ ++G ++ + C+ GY L + ++C+E GWS P+C
Sbjct: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIR 444
Query: 143 TDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDE---EVMCLNGNWTEPP 199
T + ++N I Q + Y E+ +Y+C+ Y E + C W+ P
Sbjct: 445 VKTCSKSSIDIENGFISESQYT-YALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQP 503
Query: 200 QCKDSTGKCGPPPPID---NGDITSFPLSVYAPASSVEYQCQNLYQLEGNK---RITCRN 253
C S C P ++ D T F L+ +++Y+C + Y+ I C
Sbjct: 504 TCIKS---CDIPVFMNARTKNDFTWFKLN-----DTLDYECHDGYESNTGSTTGSIVCGY 555
Query: 254 GQWSEPPKCLHPCVISREI-MENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 306
WS+ P C RE + ++ L K+ Y + GE +F CK G+ +
Sbjct: 556 NGWSDLPIC-----YERECELPKIDVHLVPDRKKDQY-KVGEVLKFSCKPGFTI 603
Score = 116 bits (291), Expect = 2e-26
Identities = 75/285 (26%), Positives = 124/285 (43%), Gaps = 20/285 (7%)
Query: 51 FYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKC----LRLCFFP-FVENGHSESSGQTHL 105
F ++ + K W C W P C ++LC P + N H+ ++ +
Sbjct: 771 FDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYR 830
Query: 106 EGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSK 165
+G+ V ++C Y +Q E I+C + W + P C C PP +++ I S + S+
Sbjct: 831 DGEKVSVLCQENYLIQEGEE-ITCKDGRWQSIPLCVEK-IPCSQPPQIEHGTINSSRSSQ 888
Query: 166 --YPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFP 223
Y G ++ Y C + + + E C G W+ PPQC+ C PP I +G +
Sbjct: 889 ESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQCEGL--PCKSPPEISHGVVAHMS 946
Query: 224 LSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWT 283
S Y V Y+C + ++G C +WS PP C+ +S EN A+
Sbjct: 947 DS-YQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFEN---AIPMG 1002
Query: 284 AKQKLYLRTGESAEFVCKRGYRLSSRSH-TLRTTCWDGKLEYPTC 327
K+ +Y + GE + C Y++ S+ T + W G+ PTC
Sbjct: 1003 EKKDVY-KAGEQVTYTCATYYKMDGASNVTCINSRWTGR---PTC 1043
Score = 104 bits (259), Expect = 1e-22
Identities = 64/246 (26%), Positives = 108/246 (43%), Gaps = 14/246 (5%)
Query: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
CD P + + F+ + Y C + S + S I C GWS P
Sbjct: 509 CDIP-----VFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI 563
Query: 83 CL-RLCFFPFVE-NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PK 139
C R C P ++ + + + G+ ++ C G+ + N++ C G S P
Sbjct: 564 CYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVG-PNSVQCYHFGLSPDLPI 622
Query: 140 CRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPP 199
C+ SC PP + N ++ + +Y E V Y C + M G ++ C++G WT P
Sbjct: 623 CKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLP 682
Query: 200 QCKDSTGKCGPPPPIDNG--DITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWS 257
C CG P +++G ++S P Y SVE+ C + + G++ ITC +G W+
Sbjct: 683 VCIVEESTCGDIPELEHGWAQLSSPP---YYYGDSVEFNCSESFTMIGHRSITCIHGVWT 739
Query: 258 EPPKCL 263
+ P+C+
Sbjct: 740 QLPQCV 745
Score = 99.8 bits (247), Expect = 3e-21
Identities = 74/302 (24%), Positives = 127/302 (42%), Gaps = 22/302 (7%)
Query: 32 ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL---RLCF 88
+L K K + EV Y C F+ + +I C + W+ P C+ C
Sbjct: 636 LLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPN---KIQCVDGEWTTLPVCIVEESTCG 692
Query: 89 -FPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSC 147
P +E+G ++ S + GD+V+ C+ + + + + I+C+ W+ P+C + D
Sbjct: 693 DIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRS-ITCIHGVWTQLPQCVAIDK-- 749
Query: 148 VNPPTVQNAHILSRQM---SKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDS 204
+ N IL + ++ +RY CR G +C+NG W C +
Sbjct: 750 LKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKE---GWIHTVCINGRWDPEVNCSMA 806
Query: 205 TGK-CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCL 263
+ C PPP I N + L+ Y V CQ Y ++ + ITC++G+W P C+
Sbjct: 807 QIQLCPPPPQIPNSHNMTTTLN-YRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCV 865
Query: 264 HPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLE 323
S+ + + Q+ Y G + C+ G+R+S + TTC+ GK
Sbjct: 866 EKIPCSQPPQIEHGTINSSRSSQESYAH-GTKLSYTCEGGFRISEEN---ETTCYMGKWS 921
Query: 324 YP 325
P
Sbjct: 922 SP 923
Score = 82.0 bits (201), Expect = 7e-16
Identities = 70/291 (24%), Positives = 111/291 (38%), Gaps = 24/291 (8%)
Query: 49 EVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL-RLCFFPFVENGHSESSGQTHLEG 107
E F Y C + + CTE GW P P C + C P++ NG H G
Sbjct: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287
Query: 108 DTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSK-- 165
D + C G+ N C GW P+C T C + P +++ + M +
Sbjct: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC--TLKPC-DYPDIKHGGLYHENMRRPY 344
Query: 166 YP--SGERVRYECRSPYEMFGD---EEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDIT 220
+P G+ Y C +E + + C W+ C KC P ++NG
Sbjct: 345 FPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPC---LRKC-YFPYLENGYNQ 400
Query: 221 SFPLSVYAPASSVEYQCQNLYQL-EGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIA 279
+ + S++ C Y L + +TC WS P+C+ S+ ++ N
Sbjct: 401 NHGRK-FVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIEN-- 457
Query: 280 LRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCW-DGKLEYPTCAK 329
+ ++ + E A++ CK GY + + TC DG PTC K
Sbjct: 458 -GFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCIK 507
Score = 80.1 bits (196), Expect = 3e-15
Identities = 57/205 (27%), Positives = 91/205 (44%), Gaps = 18/205 (8%)
Query: 72 CTEEGWS-PTPKCLRLCFFPFV--ENGHSESSG----QTHLEGDTVQIICNTGYRLQNNE 124
C +GW+ P C + P ENG SS + + G V+ +CN+GY+++ +E
Sbjct: 129 CDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE 188
Query: 125 NNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFG 184
+ C + G+ + K + + SC +P + + I Q Y ER +Y+C YE
Sbjct: 189 -EMHCSDDGFWSKEKPKCVEISCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE 245
Query: 185 DEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSV-YAPASSVEYQCQN-LYQ 242
+ +C W P C++ K P I NGD + PL + + + YQC+N Y
Sbjct: 246 RGDAVCTESGWRPLPSCEE---KSCDNPYIPNGDYS--PLRIKHRTGDEITYQCRNGFYP 300
Query: 243 LEGNKRITCRNGQWSEPPKC-LHPC 266
C + W P+C L PC
Sbjct: 301 ATRGNTAKCTSTGWIPAPRCTLKPC 325
Score = 75.1 bits (183), Expect = 8e-14
Identities = 60/220 (27%), Positives = 95/220 (43%), Gaps = 19/220 (8%)
Query: 114 CNTGYRLQNNENNISCVERGWSTP-PKCRSTDTSCVNPPTVQNAHILSRQMS---KYPSG 169
CN GY+L N C GW+ P C V P +N I+S M +Y G
Sbjct: 114 CNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAP--ENGKIVSSAMEPDREYHFG 171
Query: 170 ERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVY 227
+ VR+ C S Y++ GDEE+ C +G W+ E P+C + + K P + NG S + +Y
Sbjct: 172 QAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK---SPDVINGSPISQKI-IY 227
Query: 228 APASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQK 287
+Y+C Y+ C W P C + +N I + +
Sbjct: 228 KENERFQYKCNMGYEYSERGDAVCTESGWRPLPSC------EEKSCDNPYIPNGDYSPLR 281
Query: 288 LYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 327
+ RTG+ + C+ G+ ++R +T + T G + P C
Sbjct: 282 IKHRTGDEITYQCRNGFYPATRGNTAKCTS-TGWIPAPRC 320
Score = 65.1 bits (157), Expect = 8e-11
Identities = 61/239 (25%), Positives = 98/239 (41%), Gaps = 19/239 (7%)
Query: 100 SGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW-STPPKCRSTDTSCVNPPTVQNAHI 158
S QT+ EG C GYR N + C + W + P + C +P
Sbjct: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMV-CRKGEWVALNPLRKCQKRPCGHPGDTPFGTF 96
Query: 159 LSRQMSKYPSGERVRYECRSPYEMFGDEEVM-CLNGNWT-EPPQCKDSTGKCGPPPPIDN 216
+ + G + Y C Y++ G+ C WT + P C+ KC P +N
Sbjct: 97 TLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICE--VVKCLPVTAPEN 154
Query: 217 GDITSF---PLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPCVISRE 271
G I S P Y +V + C + Y++EG++ + C +G WS E PKC+ S +
Sbjct: 155 GKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPD 214
Query: 272 IMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 330
++ I+ QK+ + E ++ C GY S R + T G P+C ++
Sbjct: 215 VINGSPIS------QKIIYKENERFQYKCNMGYEYSERGDAVCTE--SGWRPLPSCEEK 265
Score = 55.1 bits (131), Expect = 9e-08
Identities = 46/165 (27%), Positives = 64/165 (38%), Gaps = 6/165 (3%)
Query: 147 CVNPPTVQNAHILSRQMSK--YPSGERVRYECRSPYEMFGDEEVMCLNGNWTE-PPQCKD 203
C P +N IL+ S YP G + Y+CR Y G+ ++C G W P K
Sbjct: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKC 80
Query: 204 STGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEG--NKRITCRNGQWSEPPK 261
CG P G T +V+ Y C YQL G N R +G ++ P
Sbjct: 81 QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPI 140
Query: 262 CLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 306
C + EN I + Y G++ FVC GY++
Sbjct: 141 CEVVKCLPVTAPENGKIVSSAMEPDREY-HFGQAVRFVCNSGYKI 184
>gi|239758115 PREDICTED: similar to complement factor H-related 1
isoform 2 [Homo sapiens]
Length = 271
Score = 363 bits (932), Expect = e-100
Identities = 179/273 (65%), Positives = 203/273 (74%), Gaps = 21/273 (7%)
Query: 1 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
Sbjct: 1 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
Query: 61 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
Sbjct: 61 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
Query: 121 QNNENNISCVERGWSTPPKCRSTDTS--CVNPPTVQNAHILSRQMSKYPSGERVRYECRS 178
QNNENNISCVERGWSTPPKCRSTD++ C PP + N I S +S Y V Y+C++
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 180
Query: 179 PYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPA-------- 230
Y++ G++ + C NG W+EPP KC P I + ++ +++ A
Sbjct: 181 LYQLEGNKRITCRNGQWSEPP-------KCLHPCVISREIMENYNIALRWTAKQKLYLRT 233
Query: 231 -SSVEYQCQNLYQLEGNK---RITCRNGQWSEP 259
S E+ C+ Y+L R TC +G+ P
Sbjct: 234 GESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYP 266
Score = 315 bits (806), Expect = 5e-86
Identities = 153/207 (73%), Positives = 167/207 (80%), Gaps = 8/207 (3%)
Query: 127 ISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDE 186
I+C E GWS PKC C P V+N H S + + G+ V+ C + Y + +E
Sbjct: 70 ITCTEEGWSPTPKCLRL---CFFP-FVENGHSESSGQT-HLEGDTVQIICNTGYRLQNNE 124
Query: 187 E-VMCLNGNWTEPPQCK--DSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQL 243
+ C+ W+ PP+C+ DSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQL
Sbjct: 125 NNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQL 184
Query: 244 EGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRG 303
EGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRG
Sbjct: 185 EGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRG 244
Query: 304 YRLSSRSHTLRTTCWDGKLEYPTCAKR 330
YRLSSRSHTLRTTCWDGKLEYPTCAKR
Sbjct: 245 YRLSSRSHTLRTTCWDGKLEYPTCAKR 271
Score = 35.4 bits (80), Expect = 0.071
Identities = 20/66 (30%), Positives = 32/66 (48%), Gaps = 7/66 (10%)
Query: 248 RITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLS 307
RITC WS PKCL C +EN + + + +L G++ + +C GYRL
Sbjct: 69 RITCTEEGWSPTPKCLRLCFF--PFVENGHS----ESSGQTHLE-GDTVQIICNTGYRLQ 121
Query: 308 SRSHTL 313
+ + +
Sbjct: 122 NNENNI 127
>gi|5031695 H factor (complement)-like 3 [Homo sapiens]
Length = 270
Score = 357 bits (917), Expect = 6e-99
Identities = 164/205 (80%), Positives = 178/205 (86%), Gaps = 2/205 (0%)
Query: 1 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
MWLLVSVILISRISSVGGEA FCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
Sbjct: 1 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
Query: 61 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
SPSKSFWTRITC EEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
Sbjct: 61 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
Query: 121 QNNENNISCVERGWSTPPKCRSTDTS--CVNPPTVQNAHILSRQMSKYPSGERVRYECRS 178
QNNENNISCVERGWSTPPKCRST ++ C PP + N I S +S Y G V Y+C++
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN 180
Query: 179 PYEMFGDEEVMCLNGNWTEPPQCKD 203
Y++ G+ ++ C NG W+EPP+C D
Sbjct: 181 LYQLEGNNQITCRNGQWSEPPKCLD 205
Score = 239 bits (610), Expect = 2e-63
Identities = 118/207 (57%), Positives = 144/207 (69%), Gaps = 9/207 (4%)
Query: 127 ISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDE 186
I+C E GWS PKC C P V+N H S + + G+ V+ C + Y + +E
Sbjct: 70 ITCAEEGWSPTPKCLRL---CFFP-FVENGHSESSGQT-HLEGDTVQIICNTGYRLQNNE 124
Query: 187 E-VMCLNGNWTEPPQCKD--STGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQL 243
+ C+ W+ PP+C+ S KCGPPPPIDNGDITSF LSVYAP SSVEYQCQNLYQL
Sbjct: 125 NNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQL 184
Query: 244 EGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRG 303
EGN +ITCRNGQWSEPPKCL PCVIS+EIME YNI L+WT +QKLY RTG+ EFVCK G
Sbjct: 185 EGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSG 244
Query: 304 YRLSSRSHTLRTTCWDGKLEYPTCAKR 330
Y ++SH+ R C +GKL YP+C ++
Sbjct: 245 YH-PTKSHSFRAMCQNGKLVYPSCEEK 270
Score = 35.4 bits (80), Expect = 0.071
Identities = 20/66 (30%), Positives = 32/66 (48%), Gaps = 7/66 (10%)
Query: 248 RITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLS 307
RITC WS PKCL C +EN + + + +L G++ + +C GYRL
Sbjct: 69 RITCAEEGWSPTPKCLRLCFF--PFVENGHS----ESSGQTHLE-GDTVQIICNTGYRLQ 121
Query: 308 SRSHTL 313
+ + +
Sbjct: 122 NNENNI 127
Score = 33.1 bits (74), Expect = 0.35
Identities = 23/79 (29%), Positives = 34/79 (43%), Gaps = 7/79 (8%)
Query: 69 RITCTEEGWSPTPKCLRLCFF--PFVE--NGHSESSGQTHL---EGDTVQIICNTGYRLQ 121
+ITC WS PKCL C +E N + + Q L GD V+ +C +GY
Sbjct: 189 QITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPT 248
Query: 122 NNENNISCVERGWSTPPKC 140
+ + + + G P C
Sbjct: 249 KSHSFRAMCQNGKLVYPSC 267
>gi|13540563 complement factor H-related 5 [Homo sapiens]
Length = 569
Score = 331 bits (848), Expect = 6e-91
Identities = 170/329 (51%), Positives = 200/329 (60%), Gaps = 9/329 (2%)
Query: 1 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
M LL SVILIS +S+VGGE T CDFPKI+HG LYDEE Y PFSQVPTGEVFYYSCEYNFV
Sbjct: 1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV 60
Query: 61 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
SPSKSFWTRITCTEEGWSPTPKCLR+C FPFV+NGHSESSG HLEGDTVQIICNTGY L
Sbjct: 61 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL 120
Query: 121 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180
QNNE NISCVERGWSTPP C T C P N ++ S Y G+ +++ CR
Sbjct: 121 QNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKES-YKVGDVLKFSCRKNL 179
Query: 181 EMFGDEEVMCLNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 239
G + V C W+ P CK CGPPP + NG++ Y VEY C
Sbjct: 180 IRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNP 239
Query: 240 LYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFV 299
+ + G K+I C +G+W+ P C+ I E + + + G S E
Sbjct: 240 NFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPE---LEYGYVQPSVPPYQHGVSVEVN 296
Query: 300 CKRGYRLSSRSHTLRTTCWDG-KLEYPTC 327
C+ Y + + TC +G E P C
Sbjct: 297 CRNEYAMIGNN---MITCINGIWTELPMC 322
Score = 199 bits (505), Expect = 4e-51
Identities = 101/265 (38%), Positives = 146/265 (55%), Gaps = 12/265 (4%)
Query: 70 ITCTEEGWSPTPKC-----LRLCFFPFVE-NGHSESSGQTHLEGDTVQIICNTGYRLQNN 123
ITC W+ P C L+ C V + SG+ ++ C+ +R +++
Sbjct: 309 ITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHS 368
Query: 124 ENNISCVERGWSTPPKC-RSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEM 182
C+ W+ C + C PP + NA ++ ++ Y GE+V C+ Y +
Sbjct: 369 V----CINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAVLCKENYLL 423
Query: 183 FGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQ 242
+E++C +G W P+C +ST CGPPP I+NGD TSFPLSVY P S+V Y+CQ+ Y+
Sbjct: 424 PEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYK 483
Query: 243 LEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKR 302
L+G+ +TCRN QWSEPP+CL PCV+S E M NI L+W KLY +TG++ EF CK
Sbjct: 484 LQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKF 543
Query: 303 GYRLSSRSHTLRTTCWDGKLEYPTC 327
++ S R C +GK EYP C
Sbjct: 544 PHKAMISSPPFRAICQEGKFEYPIC 568
>gi|54792787 complement factor H-related 3 [Homo sapiens]
Length = 330
Score = 304 bits (779), Expect = 6e-83
Identities = 134/330 (40%), Positives = 202/330 (61%), Gaps = 4/330 (1%)
Query: 1 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
M LL++VIL +S G+ CDFP I HG L+ E +P+ V G+ + Y C+ +F
Sbjct: 1 MLLLINVILTLWVSCANGQVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFE 60
Query: 61 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
+PS S+W I CT+ GWSP CLR C+FP++ENG++++ G+ ++G++ ++ C+ GY L
Sbjct: 61 TPSGSYWDYIHCTQNGWSPAVPCLRKCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGL 120
Query: 121 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180
+ ++C E+GWS P+C T + ++N I S S Y + ++Y+C+ Y
Sbjct: 121 PKAQTTVTCTEKGWSPTPRCIRVRTCSKSDIEIENGFI-SESSSIYILNKEIQYKCKPGY 179
Query: 181 EMFGDEE---VMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQC 237
+ CL W+ P C +S+ KCGPPPPI NGD TSF L VY P S VEYQC
Sbjct: 180 ATADGNSSGSITCLQNGWSAQPICINSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQC 239
Query: 238 QNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAE 297
Q Y+L+G+ +TC NG+WSEPP+C+HPC+I+ E M NI L+ + +K Y +TG++ E
Sbjct: 240 QPYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIE 299
Query: 298 FVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 327
F+CK GY ++ + + C +G +EYP C
Sbjct: 300 FMCKLGYNANTSILSFQAVCREGIVEYPRC 329
>gi|117320518 complement factor H-related 4 [Homo sapiens]
Length = 331
Score = 268 bits (685), Expect = 5e-72
Identities = 134/335 (40%), Positives = 194/335 (57%), Gaps = 13/335 (3%)
Query: 1 MWLLVSVILISRISSVGG-EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNF 59
M LL++VIL +S G E CDFP+I HG LY + + + G+ + Y C+ NF
Sbjct: 1 MLLLINVILTLWVSCANGQEVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNF 60
Query: 60 VSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVE--NGHSESSGQTHLEGDTVQIICNTG 117
V+PS S+W I CT++GWSPT CLR C +E NG S ++ +Q C G
Sbjct: 61 VTPSGSYWDYIHCTQDGWSPTVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPG 120
Query: 118 YRLQ--NNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYE 175
Y N+ +I+C++ GWS P C + P +N+ S M ++ + + YE
Sbjct: 121 YATADGNSSGSITCLQNGWSAQPIC----IKFCDMPVFENSRAKSNGM-RFKLHDTLDYE 175
Query: 176 CRSPYEM-FGDE--EVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASS 232
C YE+ +G+ ++C W+ P C +S+ KCGPPPPI NGD TSF L VY P S
Sbjct: 176 CYDGYEISYGNTTGSIVCGEDGWSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSR 235
Query: 233 VEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRT 292
VEYQCQ+ Y+L+G+ +TC NG+WSEPP+C+HPC+I+ E M NI L+ + K Y +T
Sbjct: 236 VEYQCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKT 295
Query: 293 GESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 327
G++ EF+CK GY ++ + + C +G +EYP C
Sbjct: 296 GDTIEFMCKLGYNANTSVLSFQAVCREGIVEYPRC 330
>gi|110611237 coagulation factor XIII B subunit precursor [Homo
sapiens]
Length = 661
Score = 171 bits (432), Expect = 1e-42
Identities = 94/292 (32%), Positives = 142/292 (48%), Gaps = 16/292 (5%)
Query: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEGWSP-TPKCL----RLCFFPFVENGHSESSGQ 102
G+V + C N+ I C GW P +P C R P N ++
Sbjct: 234 GDVVQFFCHENYYLSGSDL---IQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHST 290
Query: 103 THLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKC--RSTDTSCVNPPTVQNAHILS 160
T+ G+ V I C + + + I C + W+ PPKC +C PP ++N +
Sbjct: 291 TYRHGEIVHIECELNFEIHGSAE-IRCEDGKWTEPPKCIEGQEKVACEEPPFIENG-AAN 348
Query: 161 RQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDIT 220
Y +G++V Y C+S Y + G E+ C G WT PP+C ++ C PP + NG +
Sbjct: 349 LHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVA 408
Query: 221 SFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIAL 280
L+ YA SSVEY+C Y L G+K C G+WS PP CL PC ++ + M NI +
Sbjct: 409 DGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEM 468
Query: 281 RWTAKQKLYLRTGESAEFVCKRGYRLSSRS--HTLRTTCWDGKLEYPTCAKR 330
+W + K+ G+ +FVCK+GY LS + L C G+++YP C ++
Sbjct: 469 KWKYEGKVL--HGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRK 518
Score = 133 bits (334), Expect = 2e-31
Identities = 90/299 (30%), Positives = 141/299 (47%), Gaps = 22/299 (7%)
Query: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRL---CFFPFVENGHSESSG--Q 102
G+ Y+C+ ++ + ITC W+ P+C+ C P V + + G
Sbjct: 357 GDKVTYACKSGYLLHGSN---EITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILA 413
Query: 103 THLEGDTVQIICNTGYRLQNNENNISCVERG-WSTPPKCRSTDTSCVNPPTVQNAHILSR 161
++ G +V+ CN Y L+ ++ IS E+G WS+PP C T V+ N + +
Sbjct: 414 SYATGSSVEYRCNEYYLLRGSK--ISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWK 471
Query: 162 QMSKYPSGERVRYECRSPYEM-----FGDEEVMCLNGNWTEPPQC--KDSTGKCGPPPPI 214
K G+ + + C+ Y++ + V C G + P C K+S G C PP I
Sbjct: 472 YEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGE-VKYPLCTRKESKGMCTSPPLI 530
Query: 215 DNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIME 274
+G I S + Y SSVEY+C + + LEG++ C +G W+ PP CL PC +S ME
Sbjct: 531 KHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEME 590
Query: 275 NYNIALRWTAKQKLYLRTGESAEFVCKRG---YRLSSRSHTLRTTCWDGKLEYPTCAKR 330
N+ L+W + ++ GE EF+C+ L LR C G+L+YP C R
Sbjct: 591 KNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPR 649
Score = 104 bits (260), Expect = 9e-23
Identities = 73/257 (28%), Positives = 111/257 (43%), Gaps = 30/257 (11%)
Query: 31 GILYDEEKYKPFSQVPTGEV--FYYS-----------------CEYNFVSPSKSFWTRIT 71
G LY EEK F V G + +YY+ C + + S + T
Sbjct: 16 GELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTT 75
Query: 72 CTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQ--NNENNISC 129
CT EGWSP P+C + C P + NG+ + + ++ C +GY+ +E + C
Sbjct: 76 CTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQC 135
Query: 130 VERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFG---DE 186
+ GWS+ P CR +C+ P + +++ K ++V+YEC + Y G E
Sbjct: 136 LSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVK--DKVQYECATGYYTAGGKKTE 193
Query: 187 EVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGN 246
EV CL W+ P+C + KC I+NG Y V++ C Y L G+
Sbjct: 194 EVECLTYGWSLTPKC--TKLKCSSLRLIENGYFHPVK-QTYEEGDVVQFFCHENYYLSGS 250
Query: 247 KRITCRN-GQWSEPPKC 262
I C N G + E P C
Sbjct: 251 DLIQCYNFGWYPESPVC 267
Score = 80.5 bits (197), Expect = 2e-15
Identities = 71/260 (27%), Positives = 106/260 (40%), Gaps = 30/260 (11%)
Query: 87 CFFPFVENGHSESSGQTHLE-------GDTVQIICNTGYRLQNN--ENNISCVERGWSTP 137
C FP VENG T + C GY ++ E +C GWS
Sbjct: 25 CGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPE 84
Query: 138 PKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFG--DEEVM-CLNGN 194
P+C T P + N +I ++ Y E +RY C S Y+ G DEEV+ CL+
Sbjct: 85 PRCFKKCTK----PDLSNGYISDVKLL-YKIQENMRYGCASGYKTTGGKDEEVVQCLSDG 139
Query: 195 WTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKR---ITC 251
W+ P C+ C P + NG+ ++ + V+Y+C Y G K+ + C
Sbjct: 140 WSSQPTCRKEHETC-LAPELYNGNYSTTQ-KTFKVKDKVQYECATGYYTAGGKKTEEVEC 197
Query: 252 RNGQWSEPPKCLHPCVISREIMEN-YNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRS 310
WS PKC S ++EN Y ++ T ++ G+ +F C Y LS S
Sbjct: 198 LTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEE------GDVVQFFCHENYYLSG-S 250
Query: 311 HTLRTTCWDGKLEYPTCAKR 330
++ + E P C R
Sbjct: 251 DLIQCYNFGWYPESPVCEGR 270
>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
Length = 449
Score = 130 bits (326), Expect = 2e-30
Identities = 48/118 (40%), Positives = 78/118 (66%)
Query: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
CD+P I HG LY E +P+ V G+ + Y C+ +F +PS S+W I CT++GWSP
Sbjct: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384
Query: 83 CLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKC 140
CLR C+FP++ENG++++ G+ ++G ++ + C+ GY L + ++C+E GWS P+C
Sbjct: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC 442
Score = 80.1 bits (196), Expect = 3e-15
Identities = 57/205 (27%), Positives = 91/205 (44%), Gaps = 18/205 (8%)
Query: 72 CTEEGWS-PTPKCLRLCFFPFV--ENGHSESSG----QTHLEGDTVQIICNTGYRLQNNE 124
C +GW+ P C + P ENG SS + + G V+ +CN+GY+++ +E
Sbjct: 129 CDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE 188
Query: 125 NNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFG 184
+ C + G+ + K + + SC +P + + I Q Y ER +Y+C YE
Sbjct: 189 -EMHCSDDGFWSKEKPKCVEISCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE 245
Query: 185 DEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSV-YAPASSVEYQCQN-LYQ 242
+ +C W P C++ K P I NGD + PL + + + YQC+N Y
Sbjct: 246 RGDAVCTESGWRPLPSCEE---KSCDNPYIPNGDYS--PLRIKHRTGDEITYQCRNGFYP 300
Query: 243 LEGNKRITCRNGQWSEPPKC-LHPC 266
C + W P+C L PC
Sbjct: 301 ATRGNTAKCTSTGWIPAPRCTLKPC 325
Score = 75.1 bits (183), Expect = 8e-14
Identities = 60/220 (27%), Positives = 95/220 (43%), Gaps = 19/220 (8%)
Query: 114 CNTGYRLQNNENNISCVERGWSTP-PKCRSTDTSCVNPPTVQNAHILSRQMS---KYPSG 169
CN GY+L N C GW+ P C V P +N I+S M +Y G
Sbjct: 114 CNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAP--ENGKIVSSAMEPDREYHFG 171
Query: 170 ERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVY 227
+ VR+ C S Y++ GDEE+ C +G W+ E P+C + + K P + NG S + +Y
Sbjct: 172 QAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK---SPDVINGSPISQKI-IY 227
Query: 228 APASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQK 287
+Y+C Y+ C W P C + +N I + +
Sbjct: 228 KENERFQYKCNMGYEYSERGDAVCTESGWRPLPSC------EEKSCDNPYIPNGDYSPLR 281
Query: 288 LYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 327
+ RTG+ + C+ G+ ++R +T + T G + P C
Sbjct: 282 IKHRTGDEITYQCRNGFYPATRGNTAKCTS-TGWIPAPRC 320
Score = 68.6 bits (166), Expect = 8e-12
Identities = 54/224 (24%), Positives = 84/224 (37%), Gaps = 20/224 (8%)
Query: 49 EVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL-RLCFFPFVENGHSESSGQTHLEG 107
E F Y C + + CTE GW P P C + C P++ NG H G
Sbjct: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287
Query: 108 DTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSK-- 165
D + C G+ N C GW P+C T C + P +++ + M +
Sbjct: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC--TLKPC-DYPDIKHGGLYHENMRRPY 344
Query: 166 YP--SGERVRYECRSPYEMFGD---EEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDIT 220
+P G+ Y C +E + + C W+ C KC P ++NG
Sbjct: 345 FPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPC---LRKC-YFPYLENGYNQ 400
Query: 221 SFPLSVYAPASSVEYQCQNLYQL-EGNKRITCRNGQWSEPPKCL 263
+ + S++ C Y L + +TC WS P+C+
Sbjct: 401 NHGRK-FVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCI 443
Score = 65.1 bits (157), Expect = 8e-11
Identities = 61/239 (25%), Positives = 98/239 (41%), Gaps = 19/239 (7%)
Query: 100 SGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW-STPPKCRSTDTSCVNPPTVQNAHI 158
S QT+ EG C GYR N + C + W + P + C +P
Sbjct: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMV-CRKGEWVALNPLRKCQKRPCGHPGDTPFGTF 96
Query: 159 LSRQMSKYPSGERVRYECRSPYEMFGDEEVM-CLNGNWT-EPPQCKDSTGKCGPPPPIDN 216
+ + G + Y C Y++ G+ C WT + P C+ KC P +N
Sbjct: 97 TLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICE--VVKCLPVTAPEN 154
Query: 217 GDITSF---PLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPCVISRE 271
G I S P Y +V + C + Y++EG++ + C +G WS E PKC+ S +
Sbjct: 155 GKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPD 214
Query: 272 IMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 330
++ I+ QK+ + E ++ C GY S R + T G P+C ++
Sbjct: 215 VINGSPIS------QKIIYKENERFQYKCNMGYEYSERGDAVCTE--SGWRPLPSCEEK 265
Score = 55.1 bits (131), Expect = 9e-08
Identities = 46/165 (27%), Positives = 64/165 (38%), Gaps = 6/165 (3%)
Query: 147 CVNPPTVQNAHILSRQMSK--YPSGERVRYECRSPYEMFGDEEVMCLNGNWTE-PPQCKD 203
C P +N IL+ S YP G + Y+CR Y G+ ++C G W P K
Sbjct: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKC 80
Query: 204 STGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEG--NKRITCRNGQWSEPPK 261
CG P G T +V+ Y C YQL G N R +G ++ P
Sbjct: 81 QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPI 140
Query: 262 CLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 306
C + EN I + Y G++ FVC GY++
Sbjct: 141 CEVVKCLPVTAPENGKIVSSAMEPDREY-HFGQAVRFVCNSGYKI 184
Score = 45.4 bits (106), Expect = 7e-05
Identities = 23/66 (34%), Positives = 35/66 (53%), Gaps = 7/66 (10%)
Query: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
C FP + +G Y++ + F Q G+ +C + P T +TC E GWSPTP+
Sbjct: 389 CYFPYLENG--YNQNHGRKFVQ---GKSIDVACHPGYALPKAQ--TTVTCMENGWSPTPR 441
Query: 83 CLRLCF 88
C+R+ F
Sbjct: 442 CIRVSF 447
>gi|153266841 apolipoprotein H precursor [Homo sapiens]
Length = 345
Score = 91.3 bits (225), Expect = 1e-18
Identities = 88/311 (28%), Positives = 132/311 (42%), Gaps = 35/311 (11%)
Query: 41 PFSQVPTGEVFY-------YSCEYNFVSPSKSFWTRITCTEEGWSP--TPKCL-RLC-FF 89
PFS V + FY YSC+ +VS + + C G P T KC R+C F
Sbjct: 30 PFSTVVPLKTFYEPGEEITYSCKPGYVS--RGGMRKFICPLTGLWPINTLKCTPRVCPFA 87
Query: 90 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG-WSTPPKCRSTDTSCV 148
+ENG + T +T+ CNTG+ L N ++ C E G WS P+
Sbjct: 88 GILENGAVRYT--TFEYPNTISFSCNTGFYL-NGADSAKCTEEGKWS--PELPVCAPIIC 142
Query: 149 NPPTVQNAHILSRQMSKYPSGERVRY------ECRSPYEMFGDEEVMC-LNGNWTEPPQC 201
PP++ L ++ K +G Y EC + MFG++ + C +GNWT+ P+C
Sbjct: 143 PPPSIPTFATL--RVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPEC 200
Query: 202 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEPP 260
++ KC P DNG + + C + Y L+G + I C + G WS P
Sbjct: 201 REV--KCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMP 258
Query: 261 KCLHPC--VISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCW 318
C C + + + ++ K K + G+ F CK + S+T C
Sbjct: 259 SCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKN--KEKKCSYTEDAQCI 316
Query: 319 DGKLEYPTCAK 329
DG +E P C K
Sbjct: 317 DGTIEVPKCFK 327
>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
Length = 2489
Score = 86.7 bits (213), Expect = 3e-17
Identities = 82/310 (26%), Positives = 127/310 (40%), Gaps = 40/310 (12%)
Query: 43 SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQ 102
S P G Y C + S ITC + +PK +C + +G
Sbjct: 1411 SDFPIGTSLKYECRPEYYGRPFS----ITCLDNLVWSSPK--DVCKRKSCKTPPDPVNGM 1464
Query: 103 THL-----EGDTVQIICNTGYRLQNNENNISCVERG----WST-PPKCRSTDTSCVNPPT 152
H+ G + C TG+RL + ++ C+ G WST PP C+ C PPT
Sbjct: 1465 VHVITDIQVGSRINYSCTTGHRLIGH-SSAECILSGNTAHWSTKPPICQRIP--CGLPPT 1521
Query: 153 VQNAHILSRQMSKYPSGERVRYEC------RSPYEMFGDEEVMCLN-----GNWTEP-PQ 200
+ N +S + G V Y C R +E+ G+ + C + G W+ P PQ
Sbjct: 1522 IANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 1581
Query: 201 CKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRN-GQWS-E 258
C KC PP ++NG + S S+++ VE++CQ + ++G +R+ C+ +W E
Sbjct: 1582 CI-IPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPE 1639
Query: 259 PPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCW 318
P C C EI+ + T + G+ + C+ GY L + T
Sbjct: 1640 LPSCSRVCQPPPEILHGEH-----TPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQG 1694
Query: 319 DGKLEYPTCA 328
D E P CA
Sbjct: 1695 DWSPEAPRCA 1704
Score = 85.1 bits (209), Expect = 8e-17
Identities = 80/309 (25%), Positives = 126/309 (40%), Gaps = 40/309 (12%)
Query: 43 SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQ 102
S P G Y C + S ITC + +PK +C + +G
Sbjct: 511 SDFPIGTSLKYECRPEYYGRPFS----ITCLDNLVWSSPK--DVCKRKSCKTPPDPVNGM 564
Query: 103 THL-----EGDTVQIICNTGYRLQNNENNISCVERG----WST-PPKCRSTDTSCVNPPT 152
H+ G + C TG+RL + ++ C+ G WST PP C+ C PPT
Sbjct: 565 VHVITDIQVGSRINYSCTTGHRLIGH-SSAECILSGNAAHWSTKPPICQRIP--CGLPPT 621
Query: 153 VQNAHILSRQMSKYPSGERVRYEC------RSPYEMFGDEEVMCLN-----GNWTEP-PQ 200
+ N +S + G V Y C R +E+ G+ + C + G W+ P PQ
Sbjct: 622 IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 681
Query: 201 CKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRN-GQWS-E 258
C KC PP ++NG + S S+++ VE++CQ + ++G +R+ C+ +W E
Sbjct: 682 CI-IPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPE 739
Query: 259 PPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCW 318
P C C +++ T + K G+ + C+ GY L + T
Sbjct: 740 LPSCSRVCQPPPDVLH-----AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQG 794
Query: 319 DGKLEYPTC 327
D PTC
Sbjct: 795 DWSPAAPTC 803
Score = 85.1 bits (209), Expect = 8e-17
Identities = 80/309 (25%), Positives = 126/309 (40%), Gaps = 40/309 (12%)
Query: 43 SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQ 102
S P G Y C + S ITC + +PK +C + +G
Sbjct: 961 SDFPIGTSLKYECRPEYYGRPFS----ITCLDNLVWSSPK--DVCKRKSCKTPPDPVNGM 1014
Query: 103 THL-----EGDTVQIICNTGYRLQNNENNISCVERG----WST-PPKCRSTDTSCVNPPT 152
H+ G + C TG+RL + ++ C+ G WST PP C+ C PPT
Sbjct: 1015 VHVITDIQVGSRINYSCTTGHRLIGH-SSAECILSGNAAHWSTKPPICQRIP--CGLPPT 1071
Query: 153 VQNAHILSRQMSKYPSGERVRYEC------RSPYEMFGDEEVMCLN-----GNWTEP-PQ 200
+ N +S + G V Y C R +E+ G+ + C + G W+ P PQ
Sbjct: 1072 IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 1131
Query: 201 CKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRN-GQWS-E 258
C KC PP ++NG + S S+++ VE++CQ + ++G +R+ C+ +W E
Sbjct: 1132 CI-IPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPE 1189
Query: 259 PPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCW 318
P C C +++ T + K G+ + C+ GY L + T
Sbjct: 1190 LPSCSRVCQPPPDVLH-----AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQG 1244
Query: 319 DGKLEYPTC 327
D PTC
Sbjct: 1245 DWSPAAPTC 1253
Score = 84.7 bits (208), Expect = 1e-16
Identities = 82/309 (26%), Positives = 132/309 (42%), Gaps = 46/309 (14%)
Query: 26 PKINHG--ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSP-TP 81
P+I HG L ++ + P G+ +YSCE ++ + + CT +G WSP P
Sbjct: 2104 PEILHGEHTLSHQDNFSP------GQEVFYSCEPSYDLRGAA---SLHCTPQGDWSPEAP 2154
Query: 82 KC-LRLCFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERG----W- 134
+C ++ C + H +L+ G V +C+ G+RL+ + CV G W
Sbjct: 2155 RCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSAS-HCVLAGMKALWN 2213
Query: 135 STPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRS------PYEMFGDEEV 188
S+ P C C NPP + N P G+ + Y C + + + G+ +
Sbjct: 2214 SSVPVCEQI--FCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSI 2271
Query: 189 MCL-----NGNWTEP-PQCKDST-GKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLY 241
C NG W+ P P+C+ S C PP I NG +S+Y P ++ Y C Y
Sbjct: 2272 RCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGY 2331
Query: 242 QLEGNKRITCRN-GQWSEPPKCLHPCVISREIMENYNIALRWTAKQ---KLYLRTGESAE 297
L G I C + G WS+ H C +E+ ++ + + +K+ K G+
Sbjct: 2332 LLVGKGFIFCTDQGIWSQLD---HYC---KEVNCSFPLFMNGISKELEMKKVYHYGDYVT 2385
Query: 298 FVCKRGYRL 306
C+ GY L
Sbjct: 2386 LKCEDGYTL 2394
Score = 84.3 bits (207), Expect = 1e-16
Identities = 83/288 (28%), Positives = 116/288 (40%), Gaps = 40/288 (13%)
Query: 48 GEVFYYSCEYNFV---SPSKSFWTRITCTEEGWSPT-PKCLRLCFF------PFVENGHS 97
G YSC F SPS TC G + T K +C P + NG
Sbjct: 1927 GSTVNYSCNEGFRLIGSPST------TCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
Query: 98 ESSGQTHLEGDTVQII-CNTGYRLQN-----NENNISCVERG-----WSTPPKCRSTDTS 146
S+ +T TV C+TG + E +I C + WS+PP R T+
Sbjct: 1981 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPP-RCISTN 2039
Query: 147 CVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMC-LNGNWTEPPQCKDST 205
P V+NA + S + E +R+ C+ + M G V C NG W P+ +
Sbjct: 2040 KCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWG--PKLPHCS 2097
Query: 206 GKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC- 262
C PPP I +G+ T ++P V Y C+ Y L G + C G WS E P+C
Sbjct: 2098 RVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCT 2157
Query: 263 LHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRS 310
+ C + + + L L L+ G FVC G+RL RS
Sbjct: 2158 VKSCDDFLGQLPHGRVLL------PLNLQLGAKVSFVCDEGFRLKGRS 2199
Score = 76.3 bits (186), Expect = 4e-14
Identities = 78/257 (30%), Positives = 107/257 (41%), Gaps = 33/257 (12%)
Query: 77 WSPTPK-CLRL-CFFP-FVENGHSESSGQTHLE-GDTVQIICNTGYRLQN-----NENNI 127
WS P C R+ C P + NG S+ + + G V CN G R + E +I
Sbjct: 1504 WSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSI 1563
Query: 128 SCVERG-----WSTP-PKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYE 181
C WS P P+C C PP V+N ++S S + E V + C+ +
Sbjct: 1564 YCTSNDDQVGIWSGPAPQC-IIPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV 1621
Query: 182 MFGDEEVMCLNGNWTEP--PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 239
M G V C N EP P C + C PPP I +G+ T ++P V Y C+
Sbjct: 1622 MKGPRRVKCQALNKWEPELPSC---SRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEP 1678
Query: 240 LYQLEGNKRITCR-NGQWS-EPPKC-LHPCVISREIMENYNIALRWTAKQKLYLRTGESA 296
Y L G + C G WS E P+C + C + + + L L+ G
Sbjct: 1679 GYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLF------PLNLQLGAKV 1732
Query: 297 EFVCKRGYRL--SSRSH 311
FVC G+RL SS SH
Sbjct: 1733 SFVCDEGFRLKGSSVSH 1749
Score = 75.5 bits (184), Expect = 6e-14
Identities = 63/240 (26%), Positives = 102/240 (42%), Gaps = 29/240 (12%)
Query: 107 GDTVQIICNTGYRLQNNENNISCVERG----WSTP-PKCRSTDTSCVNPPTVQNAHILSR 161
G ++ C GYRL + ++ +C+ G W P C C PPT+ N +S
Sbjct: 124 GSQIKYSCTKGYRLIGS-SSATCIISGDTVIWDNETPICDRIP--CGLPPTITNGDFIST 180
Query: 162 QMSKYPSGERVRYEC------RSPYEMFGDEEVMCLN-----GNWTEP-PQCKDSTGKCG 209
+ G V Y C R +E+ G+ + C + G W+ P PQC KC
Sbjct: 181 NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI-IPNKC- 238
Query: 210 PPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRN-GQWS-EPPKCLHPCV 267
PP ++NG + S S+++ VE++CQ + ++G +R+ C+ +W E P C C
Sbjct: 239 TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQ 298
Query: 268 ISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 327
+++ T + K G+ + C+ GY L + T D PTC
Sbjct: 299 PPPDVLH-----AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 353
Score = 63.9 bits (154), Expect = 2e-10
Identities = 58/233 (24%), Positives = 89/233 (38%), Gaps = 27/233 (11%)
Query: 114 CNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVR 173
C GY +I C++ T K R SC NPP N + + G +++
Sbjct: 73 CRPGY--SGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMV--HVIKGIQFGSQIK 128
Query: 174 YECRSPYEMFGDEEVMCLNGNWT-----EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYA 228
Y C Y + G C+ T E P C CG PP I NGD S +
Sbjct: 129 YSCTKGYRLIGSSSATCIISGDTVIWDNETPIC--DRIPCGLPPTITNGDFISTNRENFH 186
Query: 229 PASSVEYQC------QNLYQLEGNKRITCRN-----GQWSEP-PKCLHPCVISREIMENY 276
S V Y+C + +++L G I C + G WS P P+C+ P + +EN
Sbjct: 187 YGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENG 246
Query: 277 NIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAK 329
+ + + E EF C+ G+ + + E P+C++
Sbjct: 247 IL----VSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR 295
Score = 55.8 bits (133), Expect = 5e-08
Identities = 65/262 (24%), Positives = 96/262 (36%), Gaps = 34/262 (12%)
Query: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTE-EGWSPT- 80
C P + +GIL + + S EV + C+ FV R+ C W P
Sbjct: 238 CTPPNVENGILVSDNR----SLFSLNEVVEFRCQPGFVMKGPR---RVKCQALNKWEPEL 290
Query: 81 PKCLRLCFFP--FVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPP 138
P C R+C P + ++ G V C GY L+ + + C +G +P
Sbjct: 291 PSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAAS-MRCTPQGDWSPA 349
Query: 139 KCRSTDTSCVN-PPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMC----LNG 193
SC + + N +L + G +V + C +++ G C +
Sbjct: 350 APTCEVKSCDDFMGQLLNGRVLFPVNLQL--GAKVDFVCDEGFQLKGSSASYCVLAGMES 407
Query: 194 NWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGN 246
W P C+ C PP I NG T PL V+ +V Y C + L G
Sbjct: 408 LWNSSVPVCEQIF--CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
Query: 247 KRITCR-----NGQWSEP-PKC 262
I C NG WS P P+C
Sbjct: 466 STIRCTSDPQGNGVWSSPAPRC 487
Score = 55.8 bits (133), Expect = 5e-08
Identities = 65/262 (24%), Positives = 96/262 (36%), Gaps = 34/262 (12%)
Query: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTE-EGWSPT- 80
C P + +GIL + + S EV + C+ FV R+ C W P
Sbjct: 688 CTPPNVENGILVSDNR----SLFSLNEVVEFRCQPGFVMKGPR---RVKCQALNKWEPEL 740
Query: 81 PKCLRLCFFP--FVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPP 138
P C R+C P + ++ G V C GY L+ + + C +G +P
Sbjct: 741 PSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAAS-MRCTPQGDWSPA 799
Query: 139 KCRSTDTSCVN-PPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMC----LNG 193
SC + + N +L + G +V + C +++ G C +
Sbjct: 800 APTCEVKSCDDFMGQLLNGRVLFPVNLQL--GAKVDFVCDEGFQLKGSSASYCVLAGMES 857
Query: 194 NWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGN 246
W P C+ C PP I NG T PL V+ +V Y C + L G
Sbjct: 858 LWNSSVPVCEQIF--CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 915
Query: 247 KRITCR-----NGQWSEP-PKC 262
I C NG WS P P+C
Sbjct: 916 STIRCTSDPQGNGVWSSPAPRC 937
Score = 55.8 bits (133), Expect = 5e-08
Identities = 65/262 (24%), Positives = 96/262 (36%), Gaps = 34/262 (12%)
Query: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTE-EGWSPT- 80
C P + +GIL + + S EV + C+ FV R+ C W P
Sbjct: 1138 CTPPNVENGILVSDNR----SLFSLNEVVEFRCQPGFVMKGPR---RVKCQALNKWEPEL 1190
Query: 81 PKCLRLCFFP--FVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPP 138
P C R+C P + ++ G V C GY L+ + + C +G +P
Sbjct: 1191 PSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAAS-MRCTPQGDWSPA 1249
Query: 139 KCRSTDTSCVN-PPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMC----LNG 193
SC + + N +L + G +V + C +++ G C +
Sbjct: 1250 APTCEVKSCDDFMGQLLNGRVLFPVNLQL--GAKVDFVCDEGFQLKGSSASYCVLAGMES 1307
Query: 194 NWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGN 246
W P C+ C PP I NG T PL V+ +V Y C + L G
Sbjct: 1308 LWNSSVPVCEQIF--CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 1365
Query: 247 KRITCR-----NGQWSEP-PKC 262
I C NG WS P P+C
Sbjct: 1366 STIRCTSDPQGNGVWSSPAPRC 1387
Score = 53.9 bits (128), Expect = 2e-07
Identities = 61/240 (25%), Positives = 96/240 (40%), Gaps = 42/240 (17%)
Query: 32 ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSP-TPKC-LRLCF 88
IL+ E G+ +YSCE + + + CT +G WSP P+C ++ C
Sbjct: 1653 ILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAA---SLHCTPQGDWSPEAPRCAVKSCD 1709
Query: 89 FPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERG----WSTP-PKCRS 142
+ H +L+ G V +C+ G+RL+ + + CV G W+ P C
Sbjct: 1710 DFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVS-HCVLVGMRSLWNNSVPVCEH 1768
Query: 143 TDTSCVNPPTVQNAHILSRQMSKYPSGERVRYEC------RSPYEMFGDEEVMCL----- 191
C NPP + N P G+ + Y C + + G+ + C
Sbjct: 1769 I--FCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHG 1826
Query: 192 NGNWTEP-PQCKDS--TGKCGPP-------PPIDNGDITSFPLSVYAPASSVEYQCQNLY 241
NG W+ P P+C+ S G C P P I D FP+ +S+ Y+C+ Y
Sbjct: 1827 NGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF-EFPV-----GTSLNYECRPGY 1880
Score = 53.5 bits (127), Expect = 3e-07
Identities = 39/135 (28%), Positives = 61/135 (45%), Gaps = 8/135 (5%)
Query: 134 WSTP-PKCR-STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL 191
WS+P P+C S +C +PP +QN H + +S Y G + Y C Y + G + C
Sbjct: 2283 WSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCT 2342
Query: 192 N-GNWTE-PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRI 249
+ G W++ CK+ C P ++ VY V +C++ Y LEG+
Sbjct: 2343 DQGIWSQLDHYCKEV--NCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWS 2400
Query: 250 TCRNGQWSEPP--KC 262
C+ +PP KC
Sbjct: 2401 QCQADDRWDPPLAKC 2415
Score = 43.1 bits (100), Expect = 3e-04
Identities = 61/237 (25%), Positives = 95/237 (40%), Gaps = 40/237 (16%)
Query: 54 SCEYNFVSPSKSFW-TRITCTEEGWSPTPKCLRLCFFPFVENG-HSESSGQTHLEGDTVQ 111
S Y ++ +S W + + E+ + P+P P + NG H+ + G V
Sbjct: 1296 SASYCVLAGMESLWNSSVPVCEQIFCPSP--------PVIPNGRHTGKPLEVFPFGKAVN 1347
Query: 112 IICN------TGYRLQNNENNISCVERG-----WSTP-PKCRSTDTSCVNPPTVQNAHIL 159
C+ T + L E+ I C WS+P P+C C P A +
Sbjct: 1348 YTCDPHPDRGTSFDLIG-ESTIRCTSDPQGNGVWSSPAPRCGILG-HCQAPDHFLFAKLK 1405
Query: 160 SR-QMSKYPSGERVRYECRSPYEMFGDE-EVMCL-NGNWTEPPQ-CKDSTGKCGPPPPID 215
++ S +P G ++YECR Y +G + CL N W+ P CK + C PP
Sbjct: 1406 TQTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKS--CKTPPDPV 1461
Query: 216 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC----RNGQWS-EPPKCLH-PC 266
NG + ++ S + Y C ++L G+ C WS +PP C PC
Sbjct: 1462 NGMV--HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPC 1516
Score = 39.3 bits (90), Expect = 0.005
Identities = 39/131 (29%), Positives = 57/131 (43%), Gaps = 25/131 (19%)
Query: 134 WSTP-PKCRSTDTS--CVNPPTVQNAH-ILSRQMSKYPSGERVRYECRSPY--EMFGDEE 187
WS+P P+C + + C P A + ++P G + YECR Y +MF
Sbjct: 1830 WSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFS--- 1886
Query: 188 VMCL-NGNWTE-PPQCKDSTGKCGPPPPIDNGDI-----TSFPLSVYAPASSVEYQCQNL 240
+ CL N W+ C+ + CGPPP NG + T F S+V Y C
Sbjct: 1887 ISCLENLVWSSVEDNCRRKS--CGPPPEPFNGMVHINTDTQF-------GSTVNYSCNEG 1937
Query: 241 YQLEGNKRITC 251
++L G+ TC
Sbjct: 1938 FRLIGSPSTTC 1948
Score = 34.7 bits (78), Expect = 0.12
Identities = 24/88 (27%), Positives = 37/88 (42%), Gaps = 5/88 (5%)
Query: 165 KYPSGERVRYECRSPYEMFGDEEVMCLNGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFP 223
++P G + YECR Y + N WT +C+ + C PP NG +
Sbjct: 62 EFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKS--CRNPPDPVNGMV--HV 117
Query: 224 LSVYAPASSVEYQCQNLYQLEGNKRITC 251
+ S ++Y C Y+L G+ TC
Sbjct: 118 IKGIQFGSQIKYSCTKGYRLIGSSSATC 145
>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
Length = 2039
Score = 86.7 bits (213), Expect = 3e-17
Identities = 82/310 (26%), Positives = 127/310 (40%), Gaps = 40/310 (12%)
Query: 43 SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQ 102
S P G Y C + S ITC + +PK +C + +G
Sbjct: 961 SDFPIGTSLKYECRPEYYGRPFS----ITCLDNLVWSSPK--DVCKRKSCKTPPDPVNGM 1014
Query: 103 THL-----EGDTVQIICNTGYRLQNNENNISCVERG----WST-PPKCRSTDTSCVNPPT 152
H+ G + C TG+RL + ++ C+ G WST PP C+ C PPT
Sbjct: 1015 VHVITDIQVGSRINYSCTTGHRLIGH-SSAECILSGNTAHWSTKPPICQRIP--CGLPPT 1071
Query: 153 VQNAHILSRQMSKYPSGERVRYEC------RSPYEMFGDEEVMCLN-----GNWTEP-PQ 200
+ N +S + G V Y C R +E+ G+ + C + G W+ P PQ
Sbjct: 1072 IANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 1131
Query: 201 CKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRN-GQWS-E 258
C KC PP ++NG + S S+++ VE++CQ + ++G +R+ C+ +W E
Sbjct: 1132 CI-IPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPE 1189
Query: 259 PPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCW 318
P C C EI+ + T + G+ + C+ GY L + T
Sbjct: 1190 LPSCSRVCQPPPEILHGEH-----TPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQG 1244
Query: 319 DGKLEYPTCA 328
D E P CA
Sbjct: 1245 DWSPEAPRCA 1254
Score = 85.1 bits (209), Expect = 8e-17
Identities = 80/309 (25%), Positives = 126/309 (40%), Gaps = 40/309 (12%)
Query: 43 SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQ 102
S P G Y C + S ITC + +PK +C + +G
Sbjct: 511 SDFPIGTSLKYECRPEYYGRPFS----ITCLDNLVWSSPK--DVCKRKSCKTPPDPVNGM 564
Query: 103 THL-----EGDTVQIICNTGYRLQNNENNISCVERG----WST-PPKCRSTDTSCVNPPT 152
H+ G + C TG+RL + ++ C+ G WST PP C+ C PPT
Sbjct: 565 VHVITDIQVGSRINYSCTTGHRLIGH-SSAECILSGNAAHWSTKPPICQRIP--CGLPPT 621
Query: 153 VQNAHILSRQMSKYPSGERVRYEC------RSPYEMFGDEEVMCLN-----GNWTEP-PQ 200
+ N +S + G V Y C R +E+ G+ + C + G W+ P PQ
Sbjct: 622 IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 681
Query: 201 CKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRN-GQWS-E 258
C KC PP ++NG + S S+++ VE++CQ + ++G +R+ C+ +W E
Sbjct: 682 CI-IPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPE 739
Query: 259 PPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCW 318
P C C +++ T + K G+ + C+ GY L + T
Sbjct: 740 LPSCSRVCQPPPDVLH-----AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQG 794
Query: 319 DGKLEYPTC 327
D PTC
Sbjct: 795 DWSPAAPTC 803
Score = 84.7 bits (208), Expect = 1e-16
Identities = 82/309 (26%), Positives = 132/309 (42%), Gaps = 46/309 (14%)
Query: 26 PKINHG--ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSP-TP 81
P+I HG L ++ + P G+ +YSCE ++ + + CT +G WSP P
Sbjct: 1654 PEILHGEHTLSHQDNFSP------GQEVFYSCEPSYDLRGAA---SLHCTPQGDWSPEAP 1704
Query: 82 KC-LRLCFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERG----W- 134
+C ++ C + H +L+ G V +C+ G+RL+ + CV G W
Sbjct: 1705 RCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSAS-HCVLAGMKALWN 1763
Query: 135 STPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRS------PYEMFGDEEV 188
S+ P C C NPP + N P G+ + Y C + + + G+ +
Sbjct: 1764 SSVPVCEQI--FCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSI 1821
Query: 189 MCL-----NGNWTEP-PQCKDST-GKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLY 241
C NG W+ P P+C+ S C PP I NG +S+Y P ++ Y C Y
Sbjct: 1822 RCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGY 1881
Query: 242 QLEGNKRITCRN-GQWSEPPKCLHPCVISREIMENYNIALRWTAKQ---KLYLRTGESAE 297
L G I C + G WS+ H C +E+ ++ + + +K+ K G+
Sbjct: 1882 LLVGKGFIFCTDQGIWSQLD---HYC---KEVNCSFPLFMNGISKELEMKKVYHYGDYVT 1935
Query: 298 FVCKRGYRL 306
C+ GY L
Sbjct: 1936 LKCEDGYTL 1944
Score = 84.3 bits (207), Expect = 1e-16
Identities = 83/288 (28%), Positives = 116/288 (40%), Gaps = 40/288 (13%)
Query: 48 GEVFYYSCEYNFV---SPSKSFWTRITCTEEGWSPT-PKCLRLCFF------PFVENGHS 97
G YSC F SPS TC G + T K +C P + NG
Sbjct: 1477 GSTVNYSCNEGFRLIGSPST------TCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1530
Query: 98 ESSGQTHLEGDTVQII-CNTGYRLQN-----NENNISCVERG-----WSTPPKCRSTDTS 146
S+ +T TV C+TG + E +I C + WS+PP R T+
Sbjct: 1531 YSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPP-RCISTN 1589
Query: 147 CVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMC-LNGNWTEPPQCKDST 205
P V+NA + S + E +R+ C+ + M G V C NG W P+ +
Sbjct: 1590 KCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWG--PKLPHCS 1647
Query: 206 GKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC- 262
C PPP I +G+ T ++P V Y C+ Y L G + C G WS E P+C
Sbjct: 1648 RVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCT 1707
Query: 263 LHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRS 310
+ C + + + L L L+ G FVC G+RL RS
Sbjct: 1708 VKSCDDFLGQLPHGRVLL------PLNLQLGAKVSFVCDEGFRLKGRS 1749
Score = 76.3 bits (186), Expect = 4e-14
Identities = 78/257 (30%), Positives = 107/257 (41%), Gaps = 33/257 (12%)
Query: 77 WSPTPK-CLRL-CFFP-FVENGHSESSGQTHLE-GDTVQIICNTGYRLQN-----NENNI 127
WS P C R+ C P + NG S+ + + G V CN G R + E +I
Sbjct: 1054 WSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSI 1113
Query: 128 SCVERG-----WSTP-PKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYE 181
C WS P P+C C PP V+N ++S S + E V + C+ +
Sbjct: 1114 YCTSNDDQVGIWSGPAPQC-IIPNKCT-PPNVENGILVSDNRSLFSLNEVVEFRCQPGFV 1171
Query: 182 MFGDEEVMCLNGNWTEP--PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 239
M G V C N EP P C + C PPP I +G+ T ++P V Y C+
Sbjct: 1172 MKGPRRVKCQALNKWEPELPSC---SRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEP 1228
Query: 240 LYQLEGNKRITCR-NGQWS-EPPKC-LHPCVISREIMENYNIALRWTAKQKLYLRTGESA 296
Y L G + C G WS E P+C + C + + + L L+ G
Sbjct: 1229 GYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLF------PLNLQLGAKV 1282
Query: 297 EFVCKRGYRL--SSRSH 311
FVC G+RL SS SH
Sbjct: 1283 SFVCDEGFRLKGSSVSH 1299
Score = 75.5 bits (184), Expect = 6e-14
Identities = 63/240 (26%), Positives = 102/240 (42%), Gaps = 29/240 (12%)
Query: 107 GDTVQIICNTGYRLQNNENNISCVERG----WSTP-PKCRSTDTSCVNPPTVQNAHILSR 161
G ++ C GYRL + ++ +C+ G W P C C PPT+ N +S
Sbjct: 124 GSQIKYSCTKGYRLIGS-SSATCIISGDTVIWDNETPICDRIP--CGLPPTITNGDFIST 180
Query: 162 QMSKYPSGERVRYEC------RSPYEMFGDEEVMCLN-----GNWTEP-PQCKDSTGKCG 209
+ G V Y C R +E+ G+ + C + G W+ P PQC KC
Sbjct: 181 NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI-IPNKC- 238
Query: 210 PPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRN-GQWS-EPPKCLHPCV 267
PP ++NG + S S+++ VE++CQ + ++G +R+ C+ +W E P C C
Sbjct: 239 TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQ 298
Query: 268 ISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 327
+++ T + K G+ + C+ GY L + T D PTC
Sbjct: 299 PPPDVLH-----AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 353
Score = 63.9 bits (154), Expect = 2e-10
Identities = 58/233 (24%), Positives = 89/233 (38%), Gaps = 27/233 (11%)
Query: 114 CNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVR 173
C GY +I C++ T K R SC NPP N + + G +++
Sbjct: 73 CRPGY--SGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMV--HVIKGIQFGSQIK 128
Query: 174 YECRSPYEMFGDEEVMCLNGNWT-----EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYA 228
Y C Y + G C+ T E P C CG PP I NGD S +
Sbjct: 129 YSCTKGYRLIGSSSATCIISGDTVIWDNETPIC--DRIPCGLPPTITNGDFISTNRENFH 186
Query: 229 PASSVEYQC------QNLYQLEGNKRITCRN-----GQWSEP-PKCLHPCVISREIMENY 276
S V Y+C + +++L G I C + G WS P P+C+ P + +EN
Sbjct: 187 YGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENG 246
Query: 277 NIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAK 329
+ + + E EF C+ G+ + + E P+C++
Sbjct: 247 IL----VSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR 295
Score = 55.8 bits (133), Expect = 5e-08
Identities = 65/262 (24%), Positives = 96/262 (36%), Gaps = 34/262 (12%)
Query: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTE-EGWSPT- 80
C P + +GIL + + S EV + C+ FV R+ C W P
Sbjct: 238 CTPPNVENGILVSDNR----SLFSLNEVVEFRCQPGFVMKGPR---RVKCQALNKWEPEL 290
Query: 81 PKCLRLCFFP--FVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPP 138
P C R+C P + ++ G V C GY L+ + + C +G +P
Sbjct: 291 PSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAAS-MRCTPQGDWSPA 349
Query: 139 KCRSTDTSCVN-PPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMC----LNG 193
SC + + N +L + G +V + C +++ G C +
Sbjct: 350 APTCEVKSCDDFMGQLLNGRVLFPVNLQL--GAKVDFVCDEGFQLKGSSASYCVLAGMES 407
Query: 194 NWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGN 246
W P C+ C PP I NG T PL V+ +V Y C + L G
Sbjct: 408 LWNSSVPVCEQIF--CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGE 465
Query: 247 KRITCR-----NGQWSEP-PKC 262
I C NG WS P P+C
Sbjct: 466 STIRCTSDPQGNGVWSSPAPRC 487
Score = 55.8 bits (133), Expect = 5e-08
Identities = 65/262 (24%), Positives = 96/262 (36%), Gaps = 34/262 (12%)
Query: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTE-EGWSPT- 80
C P + +GIL + + S EV + C+ FV R+ C W P
Sbjct: 688 CTPPNVENGILVSDNR----SLFSLNEVVEFRCQPGFVMKGPR---RVKCQALNKWEPEL 740
Query: 81 PKCLRLCFFP--FVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPP 138
P C R+C P + ++ G V C GY L+ + + C +G +P
Sbjct: 741 PSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAAS-MRCTPQGDWSPA 799
Query: 139 KCRSTDTSCVN-PPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMC----LNG 193
SC + + N +L + G +V + C +++ G C +
Sbjct: 800 APTCEVKSCDDFMGQLLNGRVLFPVNLQL--GAKVDFVCDEGFQLKGSSASYCVLAGMES 857
Query: 194 NWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGN 246
W P C+ C PP I NG T PL V+ +V Y C + L G
Sbjct: 858 LWNSSVPVCEQIF--CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE 915
Query: 247 KRITCR-----NGQWSEP-PKC 262
I C NG WS P P+C
Sbjct: 916 STIRCTSDPQGNGVWSSPAPRC 937
Score = 53.9 bits (128), Expect = 2e-07
Identities = 61/240 (25%), Positives = 96/240 (40%), Gaps = 42/240 (17%)
Query: 32 ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSP-TPKC-LRLCF 88
IL+ E G+ +YSCE + + + CT +G WSP P+C ++ C
Sbjct: 1203 ILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAA---SLHCTPQGDWSPEAPRCAVKSCD 1259
Query: 89 FPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERG----WSTP-PKCRS 142
+ H +L+ G V +C+ G+RL+ + + CV G W+ P C
Sbjct: 1260 DFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVS-HCVLVGMRSLWNNSVPVCEH 1318
Query: 143 TDTSCVNPPTVQNAHILSRQMSKYPSGERVRYEC------RSPYEMFGDEEVMCL----- 191
C NPP + N P G+ + Y C + + G+ + C
Sbjct: 1319 I--FCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHG 1376
Query: 192 NGNWTEP-PQCKDS--TGKCGPP-------PPIDNGDITSFPLSVYAPASSVEYQCQNLY 241
NG W+ P P+C+ S G C P P I D FP+ +S+ Y+C+ Y
Sbjct: 1377 NGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF-EFPV-----GTSLNYECRPGY 1430
Score = 53.5 bits (127), Expect = 3e-07
Identities = 39/135 (28%), Positives = 61/135 (45%), Gaps = 8/135 (5%)
Query: 134 WSTP-PKCR-STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL 191
WS+P P+C S +C +PP +QN H + +S Y G + Y C Y + G + C
Sbjct: 1833 WSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCT 1892
Query: 192 N-GNWTE-PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRI 249
+ G W++ CK+ C P ++ VY V +C++ Y LEG+
Sbjct: 1893 DQGIWSQLDHYCKEV--NCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWS 1950
Query: 250 TCRNGQWSEPP--KC 262
C+ +PP KC
Sbjct: 1951 QCQADDRWDPPLAKC 1965
Score = 43.1 bits (100), Expect = 3e-04
Identities = 61/237 (25%), Positives = 95/237 (40%), Gaps = 40/237 (16%)
Query: 54 SCEYNFVSPSKSFW-TRITCTEEGWSPTPKCLRLCFFPFVENG-HSESSGQTHLEGDTVQ 111
S Y ++ +S W + + E+ + P+P P + NG H+ + G V
Sbjct: 846 SASYCVLAGMESLWNSSVPVCEQIFCPSP--------PVIPNGRHTGKPLEVFPFGKAVN 897
Query: 112 IICN------TGYRLQNNENNISCVERG-----WSTP-PKCRSTDTSCVNPPTVQNAHIL 159
C+ T + L E+ I C WS+P P+C C P A +
Sbjct: 898 YTCDPHPDRGTSFDLIG-ESTIRCTSDPQGNGVWSSPAPRCGILG-HCQAPDHFLFAKLK 955
Query: 160 SR-QMSKYPSGERVRYECRSPYEMFGDE-EVMCL-NGNWTEPPQ-CKDSTGKCGPPPPID 215
++ S +P G ++YECR Y +G + CL N W+ P CK + C PP
Sbjct: 956 TQTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKS--CKTPPDPV 1011
Query: 216 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC----RNGQWS-EPPKCLH-PC 266
NG + ++ S + Y C ++L G+ C WS +PP C PC
Sbjct: 1012 NGMV--HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPC 1066
Score = 39.3 bits (90), Expect = 0.005
Identities = 39/131 (29%), Positives = 57/131 (43%), Gaps = 25/131 (19%)
Query: 134 WSTP-PKCRSTDTS--CVNPPTVQNAH-ILSRQMSKYPSGERVRYECRSPY--EMFGDEE 187
WS+P P+C + + C P A + ++P G + YECR Y +MF
Sbjct: 1380 WSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFS--- 1436
Query: 188 VMCL-NGNWTE-PPQCKDSTGKCGPPPPIDNGDI-----TSFPLSVYAPASSVEYQCQNL 240
+ CL N W+ C+ + CGPPP NG + T F S+V Y C
Sbjct: 1437 ISCLENLVWSSVEDNCRRKS--CGPPPEPFNGMVHINTDTQF-------GSTVNYSCNEG 1487
Query: 241 YQLEGNKRITC 251
++L G+ TC
Sbjct: 1488 FRLIGSPSTTC 1498
Score = 34.7 bits (78), Expect = 0.12
Identities = 24/88 (27%), Positives = 37/88 (42%), Gaps = 5/88 (5%)
Query: 165 KYPSGERVRYECRSPYEMFGDEEVMCLNGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFP 223
++P G + YECR Y + N WT +C+ + C PP NG +
Sbjct: 62 EFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKS--CRNPPDPVNGMV--HV 117
Query: 224 LSVYAPASSVEYQCQNLYQLEGNKRITC 251
+ S ++Y C Y+L G+ TC
Sbjct: 118 IKGIQFGSQIKYSCTKGYRLIGSSSATC 145
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 85.1 bits (209), Expect = 8e-17
Identities = 90/294 (30%), Positives = 128/294 (43%), Gaps = 35/294 (11%)
Query: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS-PTPKCLRL-CFFPFVENGHSESSGQTH 104
G V +Y C + S + C G W P P+C+ + C P V ++ SG+ +
Sbjct: 2916 GTVVFYDCNPGYFLFGSSV---LICQPNGQWDKPLPECIMIDCGHPGVPP-NAVLSGEKY 2971
Query: 105 LEGDTVQIICNTGYRLQNNENNISCVERG-WS-TPPKCRSTDT-SCVNPPTVQNAHILSR 161
G TV C TG R +++ +C G WS + P C T +C +P T + SR
Sbjct: 2972 TFGSTVHYSC-TGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG---SR 3027
Query: 162 QMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDI 219
Q S + + VRY C + Y + G EE CL NG+WT P+CK +CG P NG +
Sbjct: 3028 QESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECK--AVQCGNPGTTANGKV 3085
Query: 220 TSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEP-PKCLHPCVISREIMENYN 277
F + +SSV Y C Y L G C NG WS P C I N
Sbjct: 3086 --FRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPAN-- 3141
Query: 278 IALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTT----CWDGKLEYPTC 327
LR+ + G++ ++C+ GY + +RT W G + PTC
Sbjct: 3142 -GLRYGDDYVV----GQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVM--PTC 3188
Score = 67.0 bits (162), Expect = 2e-11
Identities = 75/284 (26%), Positives = 105/284 (36%), Gaps = 24/284 (8%)
Query: 53 YSCEYNFVSPSKSFWTRITCTEEGWS-PTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQ 111
Y C F S RI + WS P C+ + + +SG D V
Sbjct: 2801 YQCNPGFRLIGSS--VRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVT 2858
Query: 112 IICNTGYRLQNNENNISCVERGWS-TPPKCRSTDTSCVNPPTVQNAHILSR-QMSKYPSG 169
CN GY +Q R WS PP C+ +C +P N+ S+ + + G
Sbjct: 2859 FSCNIGYLMQGPTKAQCQANRQWSHPPPMCKV--VNCSDPGIPANSKRESKIEHGNFTYG 2916
Query: 170 ERVRYECRSPYEMFGDEEVMCL-NGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVY 227
V Y+C Y +FG ++C NG W +P P+C CG P N ++ Y
Sbjct: 2917 TVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPEC--IMIDCGHPGVPPNAVLSG---EKY 2971
Query: 228 APASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPCVISREIMENYNIALRWTAK 285
S+V Y C L G TC+ NG WS P C + ++
Sbjct: 2972 TFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG----SR 3027
Query: 286 QKLYLRTGESAEFVCKRGYRL--SSRSHTLRTTCWDGKLEYPTC 327
Q+ RT + + C GY L S L W G+ P C
Sbjct: 3028 QESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGR--QPEC 3069
Score = 56.6 bits (135), Expect = 3e-08
Identities = 72/289 (24%), Positives = 113/289 (39%), Gaps = 34/289 (11%)
Query: 43 SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPTP-KCLR-LCFFP-FVENGHSE 98
+Q G ++C+ F+ + C G WS + +CL C P + NG +
Sbjct: 2733 TQTSYGSTAIFTCDLGFMLVGSAVRE---CLSSGLWSESETRCLAGHCGIPELIVNG--Q 2787
Query: 99 SSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTDTSCVNPPTVQNAH 157
G+ + DTV CN G+RL + I + WS P C SC +P +
Sbjct: 2788 VIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSC--VPVSCGHP----GSP 2841
Query: 158 ILSRQMSK-YPSGERVRYECRSPYEMFGDEEVMC-LNGNWTEPPQCKDSTGKCGPPPPID 215
I R + + V + C Y M G + C N W+ PP P P +
Sbjct: 2842 IYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPAN 2901
Query: 216 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWSEP-PKCL-----HPCVI 268
+ + + + V Y C Y L G+ + C+ NGQW +P P+C+ HP V
Sbjct: 2902 SKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVP 2961
Query: 269 SREIM--ENY----NIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSH 311
++ E Y + T K+ L G+S+ G+ S+ H
Sbjct: 2962 PNAVLSGEKYTFGSTVHYSCTGKRSL---LGQSSRTCQLNGHWSGSQPH 3007
Score = 52.8 bits (125), Expect = 4e-07
Identities = 78/301 (25%), Positives = 119/301 (39%), Gaps = 44/301 (14%)
Query: 50 VFYYSCEYNF--VSPSKSFWTRITCTEEGW-SPTPKCLRL-CFFPFVE-NGHSESSGQTH 104
V ++C+ F V S + + + W +P P C + C P NG ++ +
Sbjct: 2551 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTD--Y 2608
Query: 105 LEGDTVQIICNTGYRLQNNE-NNISCVERG-WST---PPKCRSTDTSCVNPPTVQNAHIL 159
L G V CN GYRL + E C G WS P+C +N +++
Sbjct: 2609 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWR 2668
Query: 160 SRQMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWT---EPPQCKDSTGKCG--PPPP 213
S Y +V + C Y G + CL NG W+ E P C+ + CG P PP
Sbjct: 2669 IVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIIS--CGELPTPP 2726
Query: 214 IDN--GDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSE-PPKCL-HPCVI 268
N G TS+ S+ + C + L G+ C +G WSE +CL C I
Sbjct: 2727 NGNKIGTQTSY-------GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGI 2779
Query: 269 SREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTL--RTTCWDGKLEYPT 326
I+ I + + ++ + C G+RL S + + W G+L P+
Sbjct: 2780 PELIVNGQVIGENYGYR--------DTVVYQCNPGFRLIGSSVRICQQDHNWSGQL--PS 2829
Query: 327 C 327
C
Sbjct: 2830 C 2830
Score = 42.7 bits (99), Expect = 4e-04
Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 17/94 (18%)
Query: 146 SCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNG---NWTEP-PQC 201
SC +P +N ++ + G+ + +EC Y + G+ + CL+G NW P P+C
Sbjct: 2183 SCPDPRPFRNGFVIGND---FTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC 2239
Query: 202 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEY 235
+ CG G+IT+ ++Y+P EY
Sbjct: 2240 E---ALCG-------GNITAMNGTIYSPGYPDEY 2263
Score = 38.1 bits (87), Expect = 0.011
Identities = 22/77 (28%), Positives = 36/77 (46%), Gaps = 5/77 (6%)
Query: 208 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSE----PPKCL 263
C PPPP+ N +I + + + YQC + L GN +TCR G+ + PP C
Sbjct: 2355 CQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2413
Query: 264 HPCVISREIMENYNIAL 280
C + +++ + L
Sbjct: 2414 VLCPANELRLDSTGVIL 2430
Score = 36.6 bits (83), Expect = 0.032
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 5/43 (11%)
Query: 229 PASSVEYQCQNLYQLEGNKRITCRNGQ----WS-EPPKCLHPC 266
P +V +QC Y+L+G +RITC + W PP C+ PC
Sbjct: 1506 PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1548
Score = 35.4 bits (80), Expect = 0.071
Identities = 54/230 (23%), Positives = 82/230 (35%), Gaps = 65/230 (28%)
Query: 96 HSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTDTSCVNPPTVQ 154
H G G TV C++GYRL + E + WS P P C D C
Sbjct: 978 HGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC---DALCGGDVRGP 1034
Query: 155 NAHILSRQMSK-YPS------------GERVRYECRSPY-EMFGDEEVMCLNGNWTEPPQ 200
+ ILS + YP+ G+ V++ + + E D ++ NG++T+P
Sbjct: 1035 SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQP-- 1092
Query: 201 CKDSTGKCGPPPPIDNG----------DITSFPLSV------------------------ 226
TG PP I+ G I+ F +S
Sbjct: 1093 LARLTGS-DLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYG 1151
Query: 227 ------YAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCLHPC 266
+ ++ + C + Y+LEG I C G WS P P+C+ C
Sbjct: 1152 SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAEC 1201
Score = 33.9 bits (76), Expect = 0.21
Identities = 26/87 (29%), Positives = 36/87 (41%), Gaps = 14/87 (16%)
Query: 227 YAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCLHPC----------VISREI 272
Y V +QC Y L+G+ ITC G +W+ P P CL C ++S
Sbjct: 2028 YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGF 2087
Query: 273 MENYNIALRWTAKQKLYLRTGESAEFV 299
NY +L T L + G +FV
Sbjct: 2088 PGNYPSSLDCTWTINLPIGFGVHLQFV 2114
Score = 33.5 bits (75), Expect = 0.27
Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 14/65 (21%)
Query: 233 VEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPC----------VISREIMENY--NI 278
+ ++CQ ++L G K I C+ N QWS P C+ PC V+S + E Y N+
Sbjct: 646 LRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNL 705
Query: 279 ALRWT 283
WT
Sbjct: 706 NCIWT 710
Score = 33.1 bits (74), Expect = 0.35
Identities = 19/63 (30%), Positives = 32/63 (50%), Gaps = 9/63 (14%)
Query: 169 GERVRYECRSPYEMFGDEEVMCLNGN---WTEP-PQCKDSTGKCGPPPPIDNGDITS--F 222
G+ + + C S Y + G E++CL G W+ P P+C +CG + G + S +
Sbjct: 1161 GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC---VAECGASATNNEGILLSPNY 1217
Query: 223 PLS 225
PL+
Sbjct: 1218 PLN 1220
Score = 33.1 bits (74), Expect = 0.35
Identities = 19/63 (30%), Positives = 29/63 (46%), Gaps = 7/63 (11%)
Query: 208 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCL 263
C P P NG + +V ++ ++C Y L GN +TC +G W+ P P+C
Sbjct: 2184 CPDPRPFRNGFVIGNDFTV---GQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCE 2240
Query: 264 HPC 266
C
Sbjct: 2241 ALC 2243
Score = 31.6 bits (70), Expect = 1.0
Identities = 24/74 (32%), Positives = 34/74 (45%), Gaps = 11/74 (14%)
Query: 107 GDTVQIICNTGYRLQNNENNISCV---ERGWSTP-PKCRSTDTSCVNPPTVQNAHILSRQ 162
GDT+ C++GYRL+ + I C+ R WS P P+C + C T +LS
Sbjct: 1161 GDTLTFSCSSGYRLEGT-SEIICLGGGRRVWSAPLPRCVA---ECGASATNNEGILLS-- 1214
Query: 163 MSKYPSGERVRYEC 176
YP +EC
Sbjct: 1215 -PNYPLNYENNHEC 1227
Score = 30.4 bits (67), Expect = 2.3
Identities = 25/87 (28%), Positives = 32/87 (36%), Gaps = 19/87 (21%)
Query: 208 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEP------PK 261
C P I NG Y S+V Y C Y L+G +TC G P P
Sbjct: 1661 CFDPGNIMNGTRLGMD---YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1717
Query: 262 CLHPC----------VISREIMENYNI 278
C PC V+S +NY++
Sbjct: 1718 CHAPCGSRSTGSEGTVLSPNYPKNYSV 1744
Score = 29.6 bits (65), Expect = 3.9
Identities = 16/51 (31%), Positives = 25/51 (49%), Gaps = 3/51 (5%)
Query: 202 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR 252
K ++ C P +NG S+ S+V++ C Y L+G K ITC+
Sbjct: 440 KTASNLCPDPGEPENGKRIGSDFSL---GSTVQFSCDEDYVLQGAKSITCQ 487
Score = 29.6 bits (65), Expect = 3.9
Identities = 27/94 (28%), Positives = 35/94 (37%), Gaps = 19/94 (20%)
Query: 61 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSG----------QTHLEGDTV 110
S S W EG T + +L + F E H E G Q H G T+
Sbjct: 1282 STSNQLWLEFNSDTEG---TDEGFQLVYTSF-ELSHCEDPGIPQFGYKISDQGHFAGSTI 1337
Query: 111 QIICNTGYRLQNNENNISCV---ERGWSTP-PKC 140
CN GY L + + + C+ R W P P C
Sbjct: 1338 IYGCNPGYTL-HGSSLLKCMTGERRAWDYPLPSC 1370
Score = 28.9 bits (63), Expect = 6.6
Identities = 16/46 (34%), Positives = 22/46 (47%), Gaps = 6/46 (13%)
Query: 227 YAPASSVEYQCQNLYQLEGNKRITCRN-----GQWSEP-PKCLHPC 266
+A SSV + C Y L G+ I C QW++ P C+ PC
Sbjct: 1854 FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPC 1899
Score = 28.5 bits (62), Expect = 8.6
Identities = 18/65 (27%), Positives = 28/65 (43%), Gaps = 8/65 (12%)
Query: 142 STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGN----W-T 196
S T+C +P N +R G+ V ++C YE+ G+E + C+ W
Sbjct: 1483 SVATACRDPGVPMNG---TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQP 1539
Query: 197 EPPQC 201
PP C
Sbjct: 1540 SPPVC 1544
Score = 28.5 bits (62), Expect = 8.6
Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 5/44 (11%)
Query: 101 GQTHLEGDTVQIICNTGYRLQNNENNISCVE---RGWSTP-PKC 140
G ++ GD V C+ GY LQ + ++I+C+ R W+ P P C
Sbjct: 2025 GDRYMVGDVVSFQCDQGYSLQGH-SHITCMPGPVRRWNYPIPIC 2067
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 85.1 bits (209), Expect = 8e-17
Identities = 90/294 (30%), Positives = 128/294 (43%), Gaps = 35/294 (11%)
Query: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS-PTPKCLRL-CFFPFVENGHSESSGQTH 104
G V +Y C + S + C G W P P+C+ + C P V ++ SG+ +
Sbjct: 2787 GTVVFYDCNPGYFLFGSSV---LICQPNGQWDKPLPECIMIDCGHPGVPP-NAVLSGEKY 2842
Query: 105 LEGDTVQIICNTGYRLQNNENNISCVERG-WS-TPPKCRSTDT-SCVNPPTVQNAHILSR 161
G TV C TG R +++ +C G WS + P C T +C +P T + SR
Sbjct: 2843 TFGSTVHYSC-TGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG---SR 2898
Query: 162 QMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDI 219
Q S + + VRY C + Y + G EE CL NG+WT P+CK +CG P NG +
Sbjct: 2899 QESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECK--AVQCGNPGTTANGKV 2956
Query: 220 TSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEP-PKCLHPCVISREIMENYN 277
F + +SSV Y C Y L G C NG WS P C I N
Sbjct: 2957 --FRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPAN-- 3012
Query: 278 IALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTT----CWDGKLEYPTC 327
LR+ + G++ ++C+ GY + +RT W G + PTC
Sbjct: 3013 -GLRYGDDYVV----GQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVM--PTC 3059
Score = 67.0 bits (162), Expect = 2e-11
Identities = 75/284 (26%), Positives = 105/284 (36%), Gaps = 24/284 (8%)
Query: 53 YSCEYNFVSPSKSFWTRITCTEEGWS-PTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQ 111
Y C F S RI + WS P C+ + + +SG D V
Sbjct: 2672 YQCNPGFRLIGSS--VRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVT 2729
Query: 112 IICNTGYRLQNNENNISCVERGWS-TPPKCRSTDTSCVNPPTVQNAHILSR-QMSKYPSG 169
CN GY +Q R WS PP C+ +C +P N+ S+ + + G
Sbjct: 2730 FSCNIGYLMQGPTKAQCQANRQWSHPPPMCKV--VNCSDPGIPANSKRESKIEHGNFTYG 2787
Query: 170 ERVRYECRSPYEMFGDEEVMCL-NGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVY 227
V Y+C Y +FG ++C NG W +P P+C CG P N ++ Y
Sbjct: 2788 TVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPEC--IMIDCGHPGVPPNAVLSG---EKY 2842
Query: 228 APASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPCVISREIMENYNIALRWTAK 285
S+V Y C L G TC+ NG WS P C + ++
Sbjct: 2843 TFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG----SR 2898
Query: 286 QKLYLRTGESAEFVCKRGYRL--SSRSHTLRTTCWDGKLEYPTC 327
Q+ RT + + C GY L S L W G+ P C
Sbjct: 2899 QESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGR--QPEC 2940
Score = 56.6 bits (135), Expect = 3e-08
Identities = 66/232 (28%), Positives = 94/232 (40%), Gaps = 25/232 (10%)
Query: 50 VFYYSCEYNF--VSPSKSFWTRITCTEEGW-SPTPKCLRL-CFFPFVE-NGHSESSGQTH 104
V ++C+ F V S + + + W +P P C + C P NG ++ +
Sbjct: 2487 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTD--Y 2544
Query: 105 LEGDTVQIICNTGYRLQNNE-NNISCVERG-WSTPPKC-RSTDTSCVNPPTVQNAHILSR 161
L G V CN GYRL + E C G WS K R SC PT N + +
Sbjct: 2545 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGNKIGT 2604
Query: 162 QMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWTEPPQCKDSTGKCGPPPPIDNGDIT 220
Q S G + C + + G CL +G W+E + + G CG P I NG +
Sbjct: 2605 QTS---YGSTAIFTCDLGFMLVGSAVRECLSSGLWSE-SETRCLAGHCGIPELIVNGQVI 2660
Query: 221 SFPLSVYAPASSVEYQCQNLYQLEGNK-RITCRNGQWS------EPPKCLHP 265
Y +V YQC ++L G+ RI ++ WS P C HP
Sbjct: 2661 G---ENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHP 2709
Score = 56.6 bits (135), Expect = 3e-08
Identities = 72/289 (24%), Positives = 113/289 (39%), Gaps = 34/289 (11%)
Query: 43 SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPTP-KCLR-LCFFP-FVENGHSE 98
+Q G ++C+ F+ + C G WS + +CL C P + NG +
Sbjct: 2604 TQTSYGSTAIFTCDLGFMLVGSAVRE---CLSSGLWSESETRCLAGHCGIPELIVNG--Q 2658
Query: 99 SSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTDTSCVNPPTVQNAH 157
G+ + DTV CN G+RL + I + WS P C SC +P +
Sbjct: 2659 VIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSC--VPVSCGHP----GSP 2712
Query: 158 ILSRQMSK-YPSGERVRYECRSPYEMFGDEEVMC-LNGNWTEPPQCKDSTGKCGPPPPID 215
I R + + V + C Y M G + C N W+ PP P P +
Sbjct: 2713 IYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPAN 2772
Query: 216 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWSEP-PKCL-----HPCVI 268
+ + + + V Y C Y L G+ + C+ NGQW +P P+C+ HP V
Sbjct: 2773 SKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVP 2832
Query: 269 SREIM--ENY----NIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSH 311
++ E Y + T K+ L G+S+ G+ S+ H
Sbjct: 2833 PNAVLSGEKYTFGSTVHYSCTGKRSL---LGQSSRTCQLNGHWSGSQPH 2878
Score = 42.7 bits (99), Expect = 4e-04
Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 17/94 (18%)
Query: 146 SCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNG---NWTEP-PQC 201
SC +P +N ++ + G+ + +EC Y + G+ + CL+G NW P P+C
Sbjct: 2119 SCPDPRPFRNGFVIGND---FTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC 2175
Query: 202 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEY 235
+ CG G+IT+ ++Y+P EY
Sbjct: 2176 E---ALCG-------GNITAMNGTIYSPGYPDEY 2199
Score = 38.1 bits (87), Expect = 0.011
Identities = 22/77 (28%), Positives = 36/77 (46%), Gaps = 5/77 (6%)
Query: 208 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSE----PPKCL 263
C PPPP+ N +I + + + YQC + L GN +TCR G+ + PP C
Sbjct: 2291 CQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2349
Query: 264 HPCVISREIMENYNIAL 280
C + +++ + L
Sbjct: 2350 VLCPANELRLDSTGVIL 2366
Score = 36.6 bits (83), Expect = 0.032
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 5/43 (11%)
Query: 229 PASSVEYQCQNLYQLEGNKRITCRNGQ----WS-EPPKCLHPC 266
P +V +QC Y+L+G +RITC + W PP C+ PC
Sbjct: 1442 PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1484
Score = 35.4 bits (80), Expect = 0.071
Identities = 54/230 (23%), Positives = 82/230 (35%), Gaps = 65/230 (28%)
Query: 96 HSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTDTSCVNPPTVQ 154
H G G TV C++GYRL + E + WS P P C D C
Sbjct: 914 HGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC---DALCGGDVRGP 970
Query: 155 NAHILSRQMSK-YPS------------GERVRYECRSPY-EMFGDEEVMCLNGNWTEPPQ 200
+ ILS + YP+ G+ V++ + + E D ++ NG++T+P
Sbjct: 971 SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQP-- 1028
Query: 201 CKDSTGKCGPPPPIDNG----------DITSFPLSV------------------------ 226
TG PP I+ G I+ F +S
Sbjct: 1029 LARLTGS-DLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYG 1087
Query: 227 ------YAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCLHPC 266
+ ++ + C + Y+LEG I C G WS P P+C+ C
Sbjct: 1088 SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAEC 1137
Score = 33.9 bits (76), Expect = 0.21
Identities = 26/87 (29%), Positives = 36/87 (41%), Gaps = 14/87 (16%)
Query: 227 YAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCLHPC----------VISREI 272
Y V +QC Y L+G+ ITC G +W+ P P CL C ++S
Sbjct: 1964 YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGF 2023
Query: 273 MENYNIALRWTAKQKLYLRTGESAEFV 299
NY +L T L + G +FV
Sbjct: 2024 PGNYPSSLDCTWTINLPIGFGVHLQFV 2050
Score = 33.5 bits (75), Expect = 0.27
Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 14/65 (21%)
Query: 233 VEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPC----------VISREIMENY--NI 278
+ ++CQ ++L G K I C+ N QWS P C+ PC V+S + E Y N+
Sbjct: 582 LRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNL 641
Query: 279 ALRWT 283
WT
Sbjct: 642 NCIWT 646
Score = 33.1 bits (74), Expect = 0.35
Identities = 19/63 (30%), Positives = 32/63 (50%), Gaps = 9/63 (14%)
Query: 169 GERVRYECRSPYEMFGDEEVMCLNGN---WTEP-PQCKDSTGKCGPPPPIDNGDITS--F 222
G+ + + C S Y + G E++CL G W+ P P+C +CG + G + S +
Sbjct: 1097 GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC---VAECGASATNNEGILLSPNY 1153
Query: 223 PLS 225
PL+
Sbjct: 1154 PLN 1156
Score = 33.1 bits (74), Expect = 0.35
Identities = 19/63 (30%), Positives = 29/63 (46%), Gaps = 7/63 (11%)
Query: 208 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCL 263
C P P NG + +V ++ ++C Y L GN +TC +G W+ P P+C
Sbjct: 2120 CPDPRPFRNGFVIGNDFTV---GQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCE 2176
Query: 264 HPC 266
C
Sbjct: 2177 ALC 2179
Score = 31.6 bits (70), Expect = 1.0
Identities = 24/74 (32%), Positives = 34/74 (45%), Gaps = 11/74 (14%)
Query: 107 GDTVQIICNTGYRLQNNENNISCV---ERGWSTP-PKCRSTDTSCVNPPTVQNAHILSRQ 162
GDT+ C++GYRL+ + I C+ R WS P P+C + C T +LS
Sbjct: 1097 GDTLTFSCSSGYRLEGT-SEIICLGGGRRVWSAPLPRCVA---ECGASATNNEGILLS-- 1150
Query: 163 MSKYPSGERVRYEC 176
YP +EC
Sbjct: 1151 -PNYPLNYENNHEC 1163
Score = 30.4 bits (67), Expect = 2.3
Identities = 25/87 (28%), Positives = 32/87 (36%), Gaps = 19/87 (21%)
Query: 208 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEP------PK 261
C P I NG Y S+V Y C Y L+G +TC G P P
Sbjct: 1597 CFDPGNIMNGTRLGMD---YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1653
Query: 262 CLHPC----------VISREIMENYNI 278
C PC V+S +NY++
Sbjct: 1654 CHAPCGSRSTGSEGTVLSPNYPKNYSV 1680
Score = 29.6 bits (65), Expect = 3.9
Identities = 16/51 (31%), Positives = 25/51 (49%), Gaps = 3/51 (5%)
Query: 202 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR 252
K ++ C P +NG S+ S+V++ C Y L+G K ITC+
Sbjct: 376 KTASNLCPDPGEPENGKRIGSDFSL---GSTVQFSCDEDYVLQGAKSITCQ 423
Score = 29.6 bits (65), Expect = 3.9
Identities = 27/94 (28%), Positives = 35/94 (37%), Gaps = 19/94 (20%)
Query: 61 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSG----------QTHLEGDTV 110
S S W EG T + +L + F E H E G Q H G T+
Sbjct: 1218 STSNQLWLEFNSDTEG---TDEGFQLVYTSF-ELSHCEDPGIPQFGYKISDQGHFAGSTI 1273
Query: 111 QIICNTGYRLQNNENNISCV---ERGWSTP-PKC 140
CN GY L + + + C+ R W P P C
Sbjct: 1274 IYGCNPGYTL-HGSSLLKCMTGERRAWDYPLPSC 1306
Score = 28.9 bits (63), Expect = 6.6
Identities = 16/46 (34%), Positives = 22/46 (47%), Gaps = 6/46 (13%)
Query: 227 YAPASSVEYQCQNLYQLEGNKRITCRN-----GQWSEP-PKCLHPC 266
+A SSV + C Y L G+ I C QW++ P C+ PC
Sbjct: 1790 FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPC 1835
Score = 28.5 bits (62), Expect = 8.6
Identities = 18/65 (27%), Positives = 28/65 (43%), Gaps = 8/65 (12%)
Query: 142 STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGN----W-T 196
S T+C +P N +R G+ V ++C YE+ G+E + C+ W
Sbjct: 1419 SVATACRDPGVPMNG---TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQP 1475
Query: 197 EPPQC 201
PP C
Sbjct: 1476 SPPVC 1480
Score = 28.5 bits (62), Expect = 8.6
Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 5/44 (11%)
Query: 101 GQTHLEGDTVQIICNTGYRLQNNENNISCVE---RGWSTP-PKC 140
G ++ GD V C+ GY LQ + ++I+C+ R W+ P P C
Sbjct: 1961 GDRYMVGDVVSFQCDQGYSLQGH-SHITCMPGPVRRWNYPIPIC 2003
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 85.1 bits (209), Expect = 8e-17
Identities = 90/294 (30%), Positives = 128/294 (43%), Gaps = 35/294 (11%)
Query: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS-PTPKCLRL-CFFPFVENGHSESSGQTH 104
G V +Y C + S + C G W P P+C+ + C P V ++ SG+ +
Sbjct: 2956 GTVVFYDCNPGYFLFGSSV---LICQPNGQWDKPLPECIMIDCGHPGVPP-NAVLSGEKY 3011
Query: 105 LEGDTVQIICNTGYRLQNNENNISCVERG-WS-TPPKCRSTDT-SCVNPPTVQNAHILSR 161
G TV C TG R +++ +C G WS + P C T +C +P T + SR
Sbjct: 3012 TFGSTVHYSC-TGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG---SR 3067
Query: 162 QMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDI 219
Q S + + VRY C + Y + G EE CL NG+WT P+CK +CG P NG +
Sbjct: 3068 QESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECK--AVQCGNPGTTANGKV 3125
Query: 220 TSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEP-PKCLHPCVISREIMENYN 277
F + +SSV Y C Y L G C NG WS P C I N
Sbjct: 3126 --FRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPAN-- 3181
Query: 278 IALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTT----CWDGKLEYPTC 327
LR+ + G++ ++C+ GY + +RT W G + PTC
Sbjct: 3182 -GLRYGDDYVV----GQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVM--PTC 3228
Score = 67.0 bits (162), Expect = 2e-11
Identities = 75/284 (26%), Positives = 105/284 (36%), Gaps = 24/284 (8%)
Query: 53 YSCEYNFVSPSKSFWTRITCTEEGWS-PTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQ 111
Y C F S RI + WS P C+ + + +SG D V
Sbjct: 2841 YQCNPGFRLIGSS--VRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVT 2898
Query: 112 IICNTGYRLQNNENNISCVERGWS-TPPKCRSTDTSCVNPPTVQNAHILSR-QMSKYPSG 169
CN GY +Q R WS PP C+ +C +P N+ S+ + + G
Sbjct: 2899 FSCNIGYLMQGPTKAQCQANRQWSHPPPMCKV--VNCSDPGIPANSKRESKIEHGNFTYG 2956
Query: 170 ERVRYECRSPYEMFGDEEVMCL-NGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVY 227
V Y+C Y +FG ++C NG W +P P+C CG P N ++ Y
Sbjct: 2957 TVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPEC--IMIDCGHPGVPPNAVLSG---EKY 3011
Query: 228 APASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPCVISREIMENYNIALRWTAK 285
S+V Y C L G TC+ NG WS P C + ++
Sbjct: 3012 TFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG----SR 3067
Query: 286 QKLYLRTGESAEFVCKRGYRL--SSRSHTLRTTCWDGKLEYPTC 327
Q+ RT + + C GY L S L W G+ P C
Sbjct: 3068 QESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGR--QPEC 3109
Score = 56.6 bits (135), Expect = 3e-08
Identities = 72/289 (24%), Positives = 113/289 (39%), Gaps = 34/289 (11%)
Query: 43 SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPTP-KCLR-LCFFP-FVENGHSE 98
+Q G ++C+ F+ + C G WS + +CL C P + NG +
Sbjct: 2773 TQTSYGSTAIFTCDLGFMLVGSAVRE---CLSSGLWSESETRCLAGHCGIPELIVNG--Q 2827
Query: 99 SSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTDTSCVNPPTVQNAH 157
G+ + DTV CN G+RL + I + WS P C SC +P +
Sbjct: 2828 VIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSC--VPVSCGHP----GSP 2881
Query: 158 ILSRQMSK-YPSGERVRYECRSPYEMFGDEEVMC-LNGNWTEPPQCKDSTGKCGPPPPID 215
I R + + V + C Y M G + C N W+ PP P P +
Sbjct: 2882 IYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPAN 2941
Query: 216 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWSEP-PKCL-----HPCVI 268
+ + + + V Y C Y L G+ + C+ NGQW +P P+C+ HP V
Sbjct: 2942 SKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVP 3001
Query: 269 SREIM--ENY----NIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSH 311
++ E Y + T K+ L G+S+ G+ S+ H
Sbjct: 3002 PNAVLSGEKYTFGSTVHYSCTGKRSL---LGQSSRTCQLNGHWSGSQPH 3047
Score = 52.8 bits (125), Expect = 4e-07
Identities = 78/301 (25%), Positives = 119/301 (39%), Gaps = 44/301 (14%)
Query: 50 VFYYSCEYNF--VSPSKSFWTRITCTEEGW-SPTPKCLRL-CFFPFVE-NGHSESSGQTH 104
V ++C+ F V S + + + W +P P C + C P NG ++ +
Sbjct: 2591 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTD--Y 2648
Query: 105 LEGDTVQIICNTGYRLQNNE-NNISCVERG-WST---PPKCRSTDTSCVNPPTVQNAHIL 159
L G V CN GYRL + E C G WS P+C +N +++
Sbjct: 2649 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWR 2708
Query: 160 SRQMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWT---EPPQCKDSTGKCG--PPPP 213
S Y +V + C Y G + CL NG W+ E P C+ + CG P PP
Sbjct: 2709 IVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIIS--CGELPTPP 2766
Query: 214 IDN--GDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSE-PPKCL-HPCVI 268
N G TS+ S+ + C + L G+ C +G WSE +CL C I
Sbjct: 2767 NGNKIGTQTSY-------GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGI 2819
Query: 269 SREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTL--RTTCWDGKLEYPT 326
I+ I + + ++ + C G+RL S + + W G+L P+
Sbjct: 2820 PELIVNGQVIGENYGYR--------DTVVYQCNPGFRLIGSSVRICQQDHNWSGQL--PS 2869
Query: 327 C 327
C
Sbjct: 2870 C 2870
Score = 42.7 bits (99), Expect = 4e-04
Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 17/94 (18%)
Query: 146 SCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNG---NWTEP-PQC 201
SC +P +N ++ + G+ + +EC Y + G+ + CL+G NW P P+C
Sbjct: 2223 SCPDPRPFRNGFVIGND---FTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRC 2279
Query: 202 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEY 235
+ CG G+IT+ ++Y+P EY
Sbjct: 2280 E---ALCG-------GNITAMNGTIYSPGYPDEY 2303
Score = 38.1 bits (87), Expect = 0.011
Identities = 22/77 (28%), Positives = 36/77 (46%), Gaps = 5/77 (6%)
Query: 208 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSE----PPKCL 263
C PPPP+ N +I + + + YQC + L GN +TCR G+ + PP C
Sbjct: 2395 CQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2453
Query: 264 HPCVISREIMENYNIAL 280
C + +++ + L
Sbjct: 2454 VLCPANELRLDSTGVIL 2470
Score = 36.6 bits (83), Expect = 0.032
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 5/43 (11%)
Query: 229 PASSVEYQCQNLYQLEGNKRITCRNGQ----WS-EPPKCLHPC 266
P +V +QC Y+L+G +RITC + W PP C+ PC
Sbjct: 1546 PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1588
Score = 35.4 bits (80), Expect = 0.071
Identities = 54/230 (23%), Positives = 82/230 (35%), Gaps = 65/230 (28%)
Query: 96 HSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTDTSCVNPPTVQ 154
H G G TV C++GYRL + E + WS P P C D C
Sbjct: 1018 HGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC---DALCGGDVRGP 1074
Query: 155 NAHILSRQMSK-YPS------------GERVRYECRSPY-EMFGDEEVMCLNGNWTEPPQ 200
+ ILS + YP+ G+ V++ + + E D ++ NG++T+P
Sbjct: 1075 SGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQP-- 1132
Query: 201 CKDSTGKCGPPPPIDNG----------DITSFPLSV------------------------ 226
TG PP I+ G I+ F +S
Sbjct: 1133 LARLTGS-DLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYG 1191
Query: 227 ------YAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCLHPC 266
+ ++ + C + Y+LEG I C G WS P P+C+ C
Sbjct: 1192 SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAEC 1241
Score = 33.9 bits (76), Expect = 0.21
Identities = 26/87 (29%), Positives = 36/87 (41%), Gaps = 14/87 (16%)
Query: 227 YAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCLHPC----------VISREI 272
Y V +QC Y L+G+ ITC G +W+ P P CL C ++S
Sbjct: 2068 YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGF 2127
Query: 273 MENYNIALRWTAKQKLYLRTGESAEFV 299
NY +L T L + G +FV
Sbjct: 2128 PGNYPSSLDCTWTINLPIGFGVHLQFV 2154
Score = 33.5 bits (75), Expect = 0.27
Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 14/65 (21%)
Query: 233 VEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPC----------VISREIMENY--NI 278
+ ++CQ ++L G K I C+ N QWS P C+ PC V+S + E Y N+
Sbjct: 686 LRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNL 745
Query: 279 ALRWT 283
WT
Sbjct: 746 NCIWT 750
Score = 33.1 bits (74), Expect = 0.35
Identities = 19/63 (30%), Positives = 32/63 (50%), Gaps = 9/63 (14%)
Query: 169 GERVRYECRSPYEMFGDEEVMCLNGN---WTEP-PQCKDSTGKCGPPPPIDNGDITS--F 222
G+ + + C S Y + G E++CL G W+ P P+C +CG + G + S +
Sbjct: 1201 GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC---VAECGASATNNEGILLSPNY 1257
Query: 223 PLS 225
PL+
Sbjct: 1258 PLN 1260
Score = 33.1 bits (74), Expect = 0.35
Identities = 19/63 (30%), Positives = 29/63 (46%), Gaps = 7/63 (11%)
Query: 208 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCL 263
C P P NG + +V ++ ++C Y L GN +TC +G W+ P P+C
Sbjct: 2224 CPDPRPFRNGFVIGNDFTV---GQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCE 2280
Query: 264 HPC 266
C
Sbjct: 2281 ALC 2283
Score = 31.6 bits (70), Expect = 1.0
Identities = 24/74 (32%), Positives = 34/74 (45%), Gaps = 11/74 (14%)
Query: 107 GDTVQIICNTGYRLQNNENNISCV---ERGWSTP-PKCRSTDTSCVNPPTVQNAHILSRQ 162
GDT+ C++GYRL+ + I C+ R WS P P+C + C T +LS
Sbjct: 1201 GDTLTFSCSSGYRLEGT-SEIICLGGGRRVWSAPLPRCVA---ECGASATNNEGILLS-- 1254
Query: 163 MSKYPSGERVRYEC 176
YP +EC
Sbjct: 1255 -PNYPLNYENNHEC 1267
Score = 30.4 bits (67), Expect = 2.3
Identities = 25/87 (28%), Positives = 32/87 (36%), Gaps = 19/87 (21%)
Query: 208 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEP------PK 261
C P I NG Y S+V Y C Y L+G +TC G P P
Sbjct: 1701 CFDPGNIMNGTRLGMD---YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1757
Query: 262 CLHPC----------VISREIMENYNI 278
C PC V+S +NY++
Sbjct: 1758 CHAPCGSRSTGSEGTVLSPNYPKNYSV 1784
Score = 29.6 bits (65), Expect = 3.9
Identities = 16/51 (31%), Positives = 25/51 (49%), Gaps = 3/51 (5%)
Query: 202 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR 252
K ++ C P +NG S+ S+V++ C Y L+G K ITC+
Sbjct: 480 KTASNLCPDPGEPENGKRIGSDFSL---GSTVQFSCDEDYVLQGAKSITCQ 527
Score = 29.6 bits (65), Expect = 3.9
Identities = 27/94 (28%), Positives = 35/94 (37%), Gaps = 19/94 (20%)
Query: 61 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSG----------QTHLEGDTV 110
S S W EG T + +L + F E H E G Q H G T+
Sbjct: 1322 STSNQLWLEFNSDTEG---TDEGFQLVYTSF-ELSHCEDPGIPQFGYKISDQGHFAGSTI 1377
Query: 111 QIICNTGYRLQNNENNISCV---ERGWSTP-PKC 140
CN GY L + + + C+ R W P P C
Sbjct: 1378 IYGCNPGYTL-HGSSLLKCMTGERRAWDYPLPSC 1410
Score = 28.9 bits (63), Expect = 6.6
Identities = 16/46 (34%), Positives = 22/46 (47%), Gaps = 6/46 (13%)
Query: 227 YAPASSVEYQCQNLYQLEGNKRITCRN-----GQWSEP-PKCLHPC 266
+A SSV + C Y L G+ I C QW++ P C+ PC
Sbjct: 1894 FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPC 1939
Score = 28.5 bits (62), Expect = 8.6
Identities = 18/65 (27%), Positives = 28/65 (43%), Gaps = 8/65 (12%)
Query: 142 STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGN----W-T 196
S T+C +P N +R G+ V ++C YE+ G+E + C+ W
Sbjct: 1523 SVATACRDPGVPMNG---TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQP 1579
Query: 197 EPPQC 201
PP C
Sbjct: 1580 SPPVC 1584
Score = 28.5 bits (62), Expect = 8.6
Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 5/44 (11%)
Query: 101 GQTHLEGDTVQIICNTGYRLQNNENNISCVE---RGWSTP-PKC 140
G ++ GD V C+ GY LQ + ++I+C+ R W+ P P C
Sbjct: 2065 GDRYMVGDVVSFQCDQGYSLQGH-SHITCMPGPVRRWNYPIPIC 2107
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 80.5 bits (197), Expect = 2e-15
Identities = 82/317 (25%), Positives = 126/317 (39%), Gaps = 48/317 (15%)
Query: 19 EATFC-DFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG- 76
E T C P I + + + +K V YSC +V S + CTE+G
Sbjct: 3060 EHTSCGSLPMIPNAFISETSSWKE-------NVITYSCRSGYVIQGSS---DLICTEKGV 3109
Query: 77 WS-PTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWS 135
WS P P C L ++ ++G+ H V++ C GY + + + +C + G
Sbjct: 3110 WSQPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRW 3169
Query: 136 TPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMC-LNGN 194
P + + C P + HIL + +V C Y G +C L+G
Sbjct: 3170 FPERISCSPKKCPLPENI--THILVHG-DDFSVNRQVSVSCAEGYTFEGVNISVCQLDGT 3226
Query: 195 WTEPPQCKDSTG--KCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR 252
W EPP +S CG P ++G + S Y S++ YQC+ Y+LEGN+ C+
Sbjct: 3227 W-EPPFSDESCSPVSCGKPESPEHGFVVG---SKYTFESTIIYQCEPGYELEGNRERVCQ 3282
Query: 253 -NGQWS------EPPKCLHPC--VISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRG 303
N QWS + +C P + + +EN TG + + C RG
Sbjct: 3283 ENRQWSGGVAICKETRCETPLEFLNGKADIENRT--------------TGPNVVYSCNRG 3328
Query: 304 YRLS--SRSHTLRTTCW 318
Y L S +H W
Sbjct: 3329 YSLEGPSEAHCTENGTW 3345
Score = 77.4 bits (189), Expect = 2e-14
Identities = 60/209 (28%), Positives = 94/209 (44%), Gaps = 21/209 (10%)
Query: 70 ITCTEEG-WSPTPK-CLRL-CFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENN 126
I C +G WS + + CL + C P + + H+ L GD C+ GY L +N
Sbjct: 2001 IECLADGKWSRSDQQCLAVSCDEPPIVD-HASPETAHRLFGDIAFYYCSDGYSLADNSQL 2059
Query: 127 ISCVERGWSTP-----PKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYE 181
+ + W P P+C + C PP+V + + S +K+ +G V ++C +
Sbjct: 2060 LCNAQGKWVPPEGQDMPRCIAH--FCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFV 2117
Query: 182 MFGDEEVMCL-NGNWTEPP---QCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQC 237
+ ++ C+ G W P QC +CG PP I NG + S Y+ + V Y C
Sbjct: 2118 LNTSAKIECMRGGQWNPSPMSIQC--IPVRCGEPPSIMNGYASG---SNYSFGAMVAYSC 2172
Query: 238 QNLYQLEGNKRITCR-NGQWSEPPKCLHP 265
+ ++G K+ TC GQWS P HP
Sbjct: 2173 NKGFYIKGEKKSTCEATGQWSSPIPTCHP 2201
Score = 72.4 bits (176), Expect = 5e-13
Identities = 66/281 (23%), Positives = 111/281 (39%), Gaps = 21/281 (7%)
Query: 39 YKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS-PTPKCLRLCFF--PFVEN 94
Y S G + YSC F + + TC G WS P P C + P VEN
Sbjct: 2156 YASGSNYSFGAMVAYSCNKGFYIKGEK---KSTCEATGQWSSPIPTCHPVSCGEPPKVEN 2212
Query: 95 GHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQ 154
G E + E + V+ CN GY+ + + R W + C PP +Q
Sbjct: 2213 GFLEHTTGRIFESE-VRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQ 2271
Query: 155 NAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMC-LNGNWTEPPQCKDSTGKCGPPPP 213
N + + + G +V++ C YE+ GD C +G W + K KC PP
Sbjct: 2272 NGFM---KGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPL 2328
Query: 214 IDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEPPKCLHPCVISREI 272
++N + + V + C+ + L+G + C + QW++ + +
Sbjct: 2329 LENQLVLK---ELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPP 2385
Query: 273 MENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTL 313
+ ++ + + +A L G + ++ C G+ L S TL
Sbjct: 2386 LISFGVPIPSSA-----LHFGSTVKYSCVGGFFLRGNSTTL 2421
Score = 72.0 bits (175), Expect = 7e-13
Identities = 65/229 (28%), Positives = 101/229 (44%), Gaps = 22/229 (9%)
Query: 90 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG-WSTPPKCRSTDTSCV 148
P ++NG + G+ G VQ CN GY L +++ +C + G W+ + C
Sbjct: 2268 PPIQNGFMK--GENFEVGSKVQFFCNEGYELV-GDSSWTCQKSGKWNKKSNPKCMPAKCP 2324
Query: 149 NPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWTEP-PQCKDSTG 206
PP ++N +L ++ V + C+ + + G + CL + W + P CK
Sbjct: 2325 EPPLLENQLVLKELTTEVGV---VTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCK--IV 2379
Query: 207 KCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWSEP-PKCLH 264
C PPP I G P S S+V+Y C + L GN C+ +G WS P P+C+
Sbjct: 2380 LCTPPPLISFG--VPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVP 2437
Query: 265 PCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTL 313
E + N I ++ A YL T A + CK G+ L + TL
Sbjct: 2438 VECPQPEEIPNGIIDVQGLA----YLST---ALYTCKPGFELVGNTTTL 2479
Score = 70.9 bits (172), Expect = 2e-12
Identities = 75/280 (26%), Positives = 116/280 (41%), Gaps = 33/280 (11%)
Query: 47 TGEVFYYSCEYNFVSPSKSFW----TRITCTEEG-WSPT-PKCLRL-CFFPFV-ENGHSE 98
+GE++ E F S + + T+ITC E G W+ P C + C P + ENG E
Sbjct: 1801 SGEIYTVGAEVTF-SCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIE 1859
Query: 99 SSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWS-TPPKCRSTDTSCVNPPTVQNAH 157
T G V CN GY L ++ + WS +PP C C +P + N
Sbjct: 1860 ELAFTF--GSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCE--PVKCSSPENINNGK 1915
Query: 158 ILSRQMSKYPSGERVRYECRSPYEMFGDEEVMC-LNGNWTE-PPQCKDSTGKCGPPPPID 215
+ ++ + Y C + Y + G + C +G W PP C CG PP I
Sbjct: 1916 YILSGLTYLSTAS---YSCDTGYSLQGPSIIECTASGIWDRAPPAC--HLVFCGEPPAIK 1970
Query: 216 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWS-EPPKCLHPCVISREIM 273
+ IT + + ++V Y C+ Y L G I C +G+WS +CL I+
Sbjct: 1971 DAVITG---NNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIV 2027
Query: 274 ENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTL 313
++ + + + G+ A + C GY L+ S L
Sbjct: 2028 DH-------ASPETAHRLFGDIAFYYCSDGYSLADNSQLL 2060
Score = 70.9 bits (172), Expect = 2e-12
Identities = 65/248 (26%), Positives = 98/248 (39%), Gaps = 28/248 (11%)
Query: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWS-PTP 81
CD P E + F++ G YSC+ + R+ WS +P
Sbjct: 2717 CDLPTA------PENGFLRFTETSMGSAVQYSCKPGHILAGSDL--RLCLENRKWSGASP 2768
Query: 82 KCLRL-CFFPF-VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-P 138
+C + C P V NG + S T+L T+ C+ GY L E ++ W P
Sbjct: 2769 RCEAISCKKPNPVMNGSIKGSNYTYLS--TLYYECDPGYVLNGTERRTCQDDKNWDEDEP 2826
Query: 139 KCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWT- 196
C D C +PP N + +Y + + Y C + + G +CL NG+W+
Sbjct: 2827 ICIPVD--CSSPPVSANGQVRG---DEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSG 2881
Query: 197 EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQ 255
P C +C PP + NG Y V + C Y L G ++TC+ +G
Sbjct: 2882 ATPDCVPV--RCATPPQLANGVTEGLD---YGFMKEVTFHCHEGYILHGAPKLTCQSDGN 2936
Query: 256 W-SEPPKC 262
W +E P C
Sbjct: 2937 WDAEIPLC 2944
Score = 67.0 bits (162), Expect = 2e-11
Identities = 65/268 (24%), Positives = 98/268 (36%), Gaps = 59/268 (22%)
Query: 96 HSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQN 155
H ++ + G V + C+ G++L N C+ +G T P SC PP ++N
Sbjct: 1640 HLRTASEDLKPGSKVNLFCDPGFQLVGNPVQY-CLNQGQWTQPLPHCERISCGVPPPLEN 1698
Query: 156 AHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQCKD---------- 203
+ +G V Y+C + Y + GD + C NG+W P C D
Sbjct: 1699 GF---HSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDC 1755
Query: 204 --------------------STG---------KCGPPPPIDNGDITSFPLSVYAPASSVE 234
TG KC P +NG + +Y + V
Sbjct: 1756 SEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSG---EIYTVGAEVT 1812
Query: 235 YQCQNLYQLEGNKRITC-RNGQWSE-PPKCLHPCVISREIMENYNIALRWTAKQKLYLRT 292
+ CQ YQL G +ITC +G+W+ P C I EN I ++L
Sbjct: 1813 FSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCI-------EELAFTF 1865
Query: 293 GESAEFVCKRGYRLS--SRSHTLRTTCW 318
G + C +GY L+ S L + W
Sbjct: 1866 GSKVTYRCNKGYTLAGDKESSCLANSSW 1893
Score = 66.2 bits (160), Expect = 4e-11
Identities = 69/292 (23%), Positives = 110/292 (37%), Gaps = 38/292 (13%)
Query: 53 YSCEYNFVSPSKSFWTRITCTEEG-WSPTPKCLRLCFF---PFVENGHSESSGQTHLEGD 108
YSC+ + S I CT G W P L F P +++ + +G +
Sbjct: 1929 YSCDTGYSLQGPSI---IECTASGIWDRAPPACHLVFCGEPPAIKD--AVITGNNFTFRN 1983
Query: 109 TVQIICNTGYRLQNNENNISCVERG-WSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYP 167
TV C GY L + I C+ G WS + + SC PP V +A S + +
Sbjct: 1984 TVTYTCKEGYTLAGLDT-IECLADGKWSRSDQ-QCLAVSCDEPPIVDHA---SPETAHRL 2038
Query: 168 SGERVRYECRSPYEMFGDEEVMC-LNGNWTEP-----PQCKDSTGKCGPPPPIDNGDITS 221
G+ Y C Y + + +++C G W P P+C C PP + + S
Sbjct: 2039 FGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRC--IAHFCEKPPSVSYSILES 2096
Query: 222 FPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEPPKCLHPCVISR-----EIMEN 275
+ +A S V ++C + L + +I C R GQW+ P + C+ R IM
Sbjct: 2097 VSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQ-CIPVRCGEPPSIMNG 2155
Query: 276 YNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 327
Y ++ G + C +G+ + + PTC
Sbjct: 2156 YASGSNYS--------FGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTC 2199
Score = 66.2 bits (160), Expect = 4e-11
Identities = 63/232 (27%), Positives = 96/232 (41%), Gaps = 25/232 (10%)
Query: 41 PFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS-PTPKCLRL-CFFPF-VENGH 96
P S + G YSC F S C +G WS P P+C+ + C P + NG
Sbjct: 2394 PSSALHFGSTVKYSCVGGFFLRGNS---TTLCQPDGTWSSPLPECVPVECPQPEEIPNGI 2450
Query: 97 SESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG-W-STPPKCRSTDTSCVNPPTVQ 154
+ G +L T C G+ L N + C E G W P C++ + C+ P +
Sbjct: 2451 IDVQGLAYLS--TALYTCKPGFELVGNTTTL-CGENGHWLGGKPTCKAIE--CLKPKEIL 2505
Query: 155 NAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLN-GNW-TEPPQCKDSTGKCGPPP 212
N + G+ V Y C + + G + CL G+W + P C + C P
Sbjct: 2506 NGKFSYTDLHY---GQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSC--NAIHCDSPQ 2560
Query: 213 PIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEP-PKCL 263
PI+NG + + Y+ + + Y C +Q+ G+ TC WS P C+
Sbjct: 2561 PIENGFVEG---ADYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSIPTCM 2609
Score = 65.1 bits (157), Expect = 8e-11
Identities = 66/236 (27%), Positives = 100/236 (42%), Gaps = 28/236 (11%)
Query: 96 HSESSGQTH----LEGDTVQIICNTGYRLQNNENNISCVERGWS-TPPKCRSTDTSCVNP 150
+++ S TH L G V CN GY L N I + W+ + P C S + C P
Sbjct: 2663 NTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIE--CDLP 2720
Query: 151 PTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGKC 208
+N + + S G V+Y C+ + + G + +CL N W+ P+C+ + C
Sbjct: 2721 TAPENGFLRFTETSM---GSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAIS--C 2775
Query: 209 GPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQ-WSE-PPKCLHPC 266
P P+ NG I S Y S++ Y+C Y L G +R TC++ + W E P C+
Sbjct: 2776 KKPNPVMNGSIKG---SNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVD 2832
Query: 267 VISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL-SSRSHT-LRTTCWDG 320
S + N + QK E+ C G+ L +RS L W G
Sbjct: 2833 CSSPPVSANGQVRGDEYTFQK-------EIEYTCNEGFLLEGARSRVCLANGSWSG 2881
Score = 62.8 bits (151), Expect = 4e-10
Identities = 51/177 (28%), Positives = 74/177 (41%), Gaps = 15/177 (8%)
Query: 94 NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG-WSTP-PKCRSTDTSCVNPP 151
NG ++ +T G V CN GY L+ + C E G WS P P C+ C P
Sbjct: 3307 NGKADIENRT--TGPNVVYSCNRGYSLEG-PSEAHCTENGTWSHPVPLCKPNP--CPVPF 3361
Query: 152 TVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWTEPPQCKDSTGKCGP 210
+ +LS + ++ + V +CR + + G + C + WT+ K CGP
Sbjct: 3362 VIPENALLSEK--EFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQT-SAKCEKISCGP 3418
Query: 211 PPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEPPKCLHPC 266
P ++N Y + Y C + Y LEG R C NG W+ PP C C
Sbjct: 3419 PAHVENAIARGVH---YQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVC 3472
Score = 61.6 bits (148), Expect = 9e-10
Identities = 49/201 (24%), Positives = 89/201 (44%), Gaps = 18/201 (8%)
Query: 69 RITCTEEG-W-SPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENN 126
++TC +G W + P C + P + H +G + + G +Q C GY+L N +
Sbjct: 2928 KLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSR 2987
Query: 127 ISCVERGWS-TPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGD 185
WS + P C S P ++ + + + G+ R +C +++ G
Sbjct: 2988 RCLSNGSWSGSSPSCLPCRCS---TPVIEYGTV---NGTDFDCGKAARIQCFKGFKLLGL 3041
Query: 186 EEVMC-LNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQL 243
E+ C +G W+ P C+ ++ CG P I N I+ + + + Y C++ Y +
Sbjct: 3042 SEITCEADGQWSSGFPHCEHTS--CGSLPMIPNAFISE---TSSWKENVITYSCRSGYVI 3096
Query: 244 EGNKRITC-RNGQWSEP-PKC 262
+G+ + C G WS+P P C
Sbjct: 3097 QGSSDLICTEKGVWSQPYPVC 3117
Score = 52.0 bits (123), Expect = 7e-07
Identities = 79/335 (23%), Positives = 120/335 (35%), Gaps = 79/335 (23%)
Query: 53 YSCEYNFVSPSKSFWTRITCTEEG-W---SPTPKCLRLCFFPFVENGHSESSGQTHLEGD 108
Y+C+ F T C E G W PT K + + NG + + G
Sbjct: 2464 YTCKPGFELVGN---TTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHY--GQ 2518
Query: 109 TVQIICNTGYRLQNNENNISCVERG-WSTP-PKCRSTDTSCVNPPTVQNAHILSRQMSKY 166
TV CN G+RL+ + ++C+E G W P C + C +P ++N + + + Y
Sbjct: 2519 TVTYSCNRGFRLEG-PSALTCLETGDWDVDAPSCNAIH--CDSPQPIENGFV---EGADY 2572
Query: 167 PSGERVRYECRSPYEMFGDEEVMCLNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSF--- 222
G + Y C +++ G C W+ P C CG PP ID GD T
Sbjct: 2573 SYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSIPTCMPID--CGLPPHIDFGDCTKLKDD 2630
Query: 223 --------------------PLSVYAPASS--------------------VEYQCQNLYQ 242
P + A A + V Y C Y+
Sbjct: 2631 QGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYE 2690
Query: 243 LEGNKRITCR-NGQWS-EPPKCLH-PCVISREIMENYNIALRWTAKQKLYLRTGESAEFV 299
L GN + C+ +G W+ P C+ C + + LR+T G + ++
Sbjct: 2691 LLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGF---LRFTETS-----MGSAVQYS 2742
Query: 300 CKRGYRL--SSRSHTLRTTCWDG---KLEYPTCAK 329
CK G+ L S L W G + E +C K
Sbjct: 2743 CKPGHILAGSDLRLCLENRKWSGASPRCEAISCKK 2777
Score = 43.9 bits (102), Expect = 2e-04
Identities = 51/245 (20%), Positives = 93/245 (37%), Gaps = 34/245 (13%)
Query: 90 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVN 149
P + H+ G T E +C GYR C +
Sbjct: 342 PCPDENHTSPPGSTSPE----DCVCREGYRASGQT---------------CELVHCPALK 382
Query: 150 PPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGK 207
PP +N + + + + + C +++ G ++CL NG W+ C+ T
Sbjct: 383 PP--ENGYFIQNTCNNHFNAA-CGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRT-- 437
Query: 208 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWSEP-PKCLHP 265
C +G I+ + + + C Y+LEG+ ++TC+ N QW P P+C+
Sbjct: 438 CPHLRQPKHGHISCSTREMLYKTTCL-VACDEGYRLEGSDKLTCQGNSQWDGPEPRCVER 496
Query: 266 CVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTC---WDGKL 322
+ ++ ++ I+ KQ + G C++G+ LS LR T W+ +
Sbjct: 497 HCSTFQMPKDVIISPHNCGKQP--AKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGV 554
Query: 323 EYPTC 327
+ C
Sbjct: 555 QAAVC 559
Score = 41.6 bits (96), Expect = 0.001
Identities = 44/145 (30%), Positives = 63/145 (43%), Gaps = 17/145 (11%)
Query: 70 ITCT-EEGWSPTP-KCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNI 127
ITC +E W+ T KC ++ P ++ + G + GD + C +GY L+ ++
Sbjct: 3396 ITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSV 3455
Query: 128 SCVERG-WSTPPKCRSTDTSCVNPPTVQNAHILSR-QMSKYPSGERVRYECRSPYEMFGD 185
C+E G W++PP CR+ C P QN I R P G R C P +
Sbjct: 3456 -CLENGTWTSPPICRAV---CRFP--CQNGGICQRPNACSCPEGWMGRL-CEEPICI--- 3505
Query: 186 EEVMCLN-GNWTEPPQCKDSTGKCG 209
+ CLN G P QC G G
Sbjct: 3506 --LPCLNGGRCVAPYQCDCPPGWTG 3528
Score = 38.9 bits (89), Expect = 0.006
Identities = 37/146 (25%), Positives = 60/146 (41%), Gaps = 14/146 (9%)
Query: 70 ITCTEEG-WSPTPKCLRLCFFPFV---ENGHSESSGQTHLEGDTVQIICNTGYRLQNNEN 125
I C G WS + R+ P + ++GH S + L T + C+ GYRL+ ++
Sbjct: 418 ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK 477
Query: 126 NISCVERGWSTP-PKCRSTDTSCVNPP--TVQNAHILSRQMSKYPSGERVRYECRSPYEM 182
W P P+C S P + + H +Q +K+ G CR + +
Sbjct: 478 LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSCRQGFIL 535
Query: 183 FGDEEVM--CLNGNWTEPPQ---CKD 203
G +E++ +G W Q CKD
Sbjct: 536 SGVKEMLRCTTSGKWNVGVQAAVCKD 561
>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
isoform 2 [Homo sapiens]
Length = 1033
Score = 78.2 bits (191), Expect = 1e-14
Identities = 67/229 (29%), Positives = 95/229 (41%), Gaps = 19/229 (8%)
Query: 90 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG-----WSTP-PKCRST 143
P + NG G ++ C+ +RL E ++ C+ + W P PKC
Sbjct: 27 PPILNGRISYYSTPIAVGTVIRYSCSGTFRLIG-EKSLLCITKDKVDGTWDKPAPKCEYF 85
Query: 144 DTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMC-LNGNW--TEPPQ 200
+ P + R + Y G+ V + C++ + M G++ V C N W T P
Sbjct: 86 NKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPT 145
Query: 201 CKDSTG-KCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSE 258
C +C P I NG TS + AP SV Y C++ Y L G K I C +G+WS
Sbjct: 146 CVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSA 205
Query: 259 -PPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 306
PP C S N + K+ LR G +A F C GYRL
Sbjct: 206 VPPTCEEARCKSLGRFPNGKV------KEPPILRVGVTANFFCDEGYRL 248
Score = 77.4 bits (189), Expect = 2e-14
Identities = 59/227 (25%), Positives = 98/227 (43%), Gaps = 18/227 (7%)
Query: 48 GEVFYYSCEYNF-VSPSKSFWTRITCTEEG-WS-PTPKCLRL-----CFFPFVENGHS-E 98
G Y C+ F + K R G WS P+P+CLR C P V++G+
Sbjct: 741 GNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLN 800
Query: 99 SSGQTHLEGDTVQIICNTGYRLQNNENNISC-VERGW--STPPKCRSTDTSCVNPPTVQN 155
+ + D V + CN G+ + N I C + W P + C PP N
Sbjct: 801 KTHSAYSHNDIVYVDCNPGF-IMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPN 859
Query: 156 AHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLN-GNWTEP-PQCKDSTGKCGPPPP 213
+ ++++ G + Y C Y + G+ ++C + G W++P P CK+ C P
Sbjct: 860 GNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN--CSSPAD 917
Query: 214 IDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNG-QWSEP 259
+D P +Y + V +C++ Y LEG+ + C++ QW+ P
Sbjct: 918 MDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPP 964
Score = 69.3 bits (168), Expect = 4e-12
Identities = 58/235 (24%), Positives = 89/235 (37%), Gaps = 21/235 (8%)
Query: 45 VPTGEVFYYSCEYNFVSPSKSFWTRITC--TEEGWS-PTPKC-----LRLCFFPFVENGH 96
+ G V YSC F + IT + W P PKC C P V G+
Sbjct: 41 IAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGY 100
Query: 97 SESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP--PKCRST-DTSCVNPPTV 153
+ GD+V C T + + N++ W P C S C P +
Sbjct: 101 KIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMI 160
Query: 154 QNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWTE-PPQCKDSTGKCGPP 211
N H S + G V Y C S Y + G++ + CL +G W+ PP C+++ +C
Sbjct: 161 HNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEA--RCKSL 218
Query: 212 PPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC----RNGQWSEPPKC 262
NG + P + + + C Y+L+G C + W++ P C
Sbjct: 219 GRFPNGKVKEPP--ILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVC 271
Score = 69.3 bits (168), Expect = 4e-12
Identities = 98/405 (24%), Positives = 140/405 (34%), Gaps = 111/405 (27%)
Query: 19 EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCE------YNFVSPSKSFWTRITC 72
E FC P IL + V G + Y+C+ NF+ +S + C
Sbjct: 272 EEIFCPSPP---PILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGES---TLRC 325
Query: 73 TEEG-----WS-PTPKC-----LRLCFFPFVENGHSESSGQT-HLEGDTVQIICNTGYRL 120
T + WS P P+C C P + G S + + DTV C G+ L
Sbjct: 326 TVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTL 385
Query: 121 QNNENNISCVERGWSTP--PKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRS 178
+ ++ I C +G P P C + C PP + N R M ++ G ++Y C
Sbjct: 386 KGSKQ-IRCNAQGTWEPSAPVC---EKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNP 441
Query: 179 PYEMFGDEEVMCLN-GNWTEP-PQCK----DSTGK------------------------- 207
Y + G+E + C + G WT P PQCK ++TG+
Sbjct: 442 GYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKL 501
Query: 208 -------------------------CGPPPPIDNGDITSFPLSVYAPASSVEYQCQN--- 239
C PPP I NG T L + ++V Y C
Sbjct: 502 SGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPE 561
Query: 240 ---LYQLEGNKRITC-----RNGQWSEP-PKCLHPCVISR----EIMENYNIALRWTAKQ 286
+ L G I C G WS P P C + + I Y I + K+
Sbjct: 562 RGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKI----SGKE 617
Query: 287 KLYLRTGESAEFVCKRGYRL--SSRSHTLRTTCWDGKLEYPTCAK 329
Y ++ F C G+ L SS+ WD E P C K
Sbjct: 618 APYF-YNDTVTFKCYSGFTLKGSSQIRCKADNTWDP--EIPVCEK 659
Score = 68.9 bits (167), Expect = 6e-12
Identities = 68/266 (25%), Positives = 103/266 (38%), Gaps = 46/266 (17%)
Query: 46 PTGEVFYYSC--------EYNFVSPSKSFWTRITCTEEGWS-PTPKC-LRL----CFFPF 91
P G Y+C E++ + S T WS P P C L L C
Sbjct: 547 PYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVH 606
Query: 92 VENGHSESSGQT-HLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTDTSCVN 149
+ NG+ S + + DTV C +G+ L+ + + W P C
Sbjct: 607 IANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEK------- 659
Query: 150 PPTVQNAHILSRQMSKYPSGERVRY---ECRSPYEMFGDEEVMCL---NGNWTEP-PQCK 202
+ + + + + P+G RV C+ Y++ G MC NG W + P CK
Sbjct: 660 ----ETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCK 715
Query: 203 DSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-----NGQWS 257
C PPP I NG T + + V Y+C + L G K++ CR +G WS
Sbjct: 716 --VIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWS 773
Query: 258 EP-PKCLHPCVISR----EIMENYNI 278
P P+CL ++R E+ Y +
Sbjct: 774 GPSPQCLRSPPVTRCPNPEVKHGYKL 799
Score = 64.3 bits (155), Expect = 1e-10
Identities = 62/257 (24%), Positives = 105/257 (40%), Gaps = 35/257 (13%)
Query: 67 WTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNN--- 123
WT++ EE + P+P P + H +S G V C+ N
Sbjct: 265 WTKMPVCEEIFCPSPP-------PILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFIL 317
Query: 124 --ENNISCVERG-----WSTP-PKCRSTDTSCVNP-PTVQNAHILSRQMSKYPSGERVRY 174
E+ + C WS P P+C + ++ P P + ++S Q +Y + V +
Sbjct: 318 IGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIF 377
Query: 175 ECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVE 234
C + + G +++ C N T P +C PP I NG + + P +S++
Sbjct: 378 ACMFGFTLKGSKQIRC-NAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIK 436
Query: 235 YQCQNLYQLEGNKRITCRN-GQWSEP-PKC-LHPC-VISREIMENYNIALRWTAKQKLYL 290
Y C Y L G + I C + G W+ P P+C + C R+++ T Q ++
Sbjct: 437 YSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLL---------TKPQHQFV 487
Query: 291 RTGESAEFVCKRGYRLS 307
R ++ C GY+LS
Sbjct: 488 RPDVNSS--CGEGYKLS 502
Score = 46.6 bits (109), Expect = 3e-05
Identities = 35/133 (26%), Positives = 56/133 (42%), Gaps = 22/133 (16%)
Query: 208 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-----RNGQWSEP-PK 261
CG PPPI NG I+ + + A + + Y C ++L G K + C +G W +P PK
Sbjct: 23 CGSPPPILNGRISYYSTPI-AVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
Query: 262 CLHPCVISREIMENYN------IALRWTAKQKLYLRTGESAEFVCKRGYRLS-SRSHTLR 314
C E Y+ + + + R G+S F CK + ++ ++S +
Sbjct: 82 C--------EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
Query: 315 TTCWDGKLEYPTC 327
G PTC
Sbjct: 134 ANNMWGPTRLPTC 146
>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
isoform 1 [Homo sapiens]
Length = 1092
Score = 78.2 bits (191), Expect = 1e-14
Identities = 67/229 (29%), Positives = 95/229 (41%), Gaps = 19/229 (8%)
Query: 90 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG-----WSTP-PKCRST 143
P + NG G ++ C+ +RL E ++ C+ + W P PKC
Sbjct: 27 PPILNGRISYYSTPIAVGTVIRYSCSGTFRLIG-EKSLLCITKDKVDGTWDKPAPKCEYF 85
Query: 144 DTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMC-LNGNW--TEPPQ 200
+ P + R + Y G+ V + C++ + M G++ V C N W T P
Sbjct: 86 NKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPT 145
Query: 201 CKDSTG-KCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSE 258
C +C P I NG TS + AP SV Y C++ Y L G K I C +G+WS
Sbjct: 146 CVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSA 205
Query: 259 -PPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 306
PP C S N + K+ LR G +A F C GYRL
Sbjct: 206 VPPTCEEARCKSLGRFPNGKV------KEPPILRVGVTANFFCDEGYRL 248
Score = 77.4 bits (189), Expect = 2e-14
Identities = 59/227 (25%), Positives = 98/227 (43%), Gaps = 18/227 (7%)
Query: 48 GEVFYYSCEYNF-VSPSKSFWTRITCTEEG-WS-PTPKCLRL-----CFFPFVENGHS-E 98
G Y C+ F + K R G WS P+P+CLR C P V++G+
Sbjct: 800 GNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLN 859
Query: 99 SSGQTHLEGDTVQIICNTGYRLQNNENNISC-VERGW--STPPKCRSTDTSCVNPPTVQN 155
+ + D V + CN G+ + N I C + W P + C PP N
Sbjct: 860 KTHSAYSHNDIVYVDCNPGF-IMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPN 918
Query: 156 AHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLN-GNWTEP-PQCKDSTGKCGPPPP 213
+ ++++ G + Y C Y + G+ ++C + G W++P P CK+ C P
Sbjct: 919 GNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN--CSSPAD 976
Query: 214 IDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNG-QWSEP 259
+D P +Y + V +C++ Y LEG+ + C++ QW+ P
Sbjct: 977 MDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPP 1023
Score = 75.9 bits (185), Expect = 5e-14
Identities = 67/234 (28%), Positives = 101/234 (43%), Gaps = 38/234 (16%)
Query: 68 TRITCTEEG-WSPT-PKCLRLCFFPFVENGHSESSGQT--HLEGDTVQIICNTGYRLQNN 123
++I C + W P P C + C P + + G T + G TV C+ GY L N
Sbjct: 640 SQIRCKADNTWDPEIPVCEKGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGN 699
Query: 124 ENNISCVERG-WS-TPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRY---ECRS 178
++ I C+ G WS + P+C T + + + + P+G RV C+
Sbjct: 700 KS-IHCMPSGNWSPSAPRCEET------------CQHVRQSLQELPAGSRVELVNTSCQD 746
Query: 179 PYEMFGDEEVMCL---NGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVE 234
Y++ G MC NG W + P CK C PPP I NG T + + V
Sbjct: 747 GYQLTGHAYQMCQDAENGIWFKKIPLCK--VIHCHPPPVIVNGKHTGMMAENFLYGNEVS 804
Query: 235 YQCQNLYQLEGNKRITCR-----NGQWSEP-PKCLHPCVISR----EIMENYNI 278
Y+C + L G K++ CR +G WS P P+CL ++R E+ Y +
Sbjct: 805 YECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKL 858
Score = 69.3 bits (168), Expect = 4e-12
Identities = 58/235 (24%), Positives = 89/235 (37%), Gaps = 21/235 (8%)
Query: 45 VPTGEVFYYSCEYNFVSPSKSFWTRITC--TEEGWS-PTPKC-----LRLCFFPFVENGH 96
+ G V YSC F + IT + W P PKC C P V G+
Sbjct: 41 IAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGY 100
Query: 97 SESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP--PKCRST-DTSCVNPPTV 153
+ GD+V C T + + N++ W P C S C P +
Sbjct: 101 KIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMI 160
Query: 154 QNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWTE-PPQCKDSTGKCGPP 211
N H S + G V Y C S Y + G++ + CL +G W+ PP C+++ +C
Sbjct: 161 HNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEA--RCKSL 218
Query: 212 PPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC----RNGQWSEPPKC 262
NG + P + + + C Y+L+G C + W++ P C
Sbjct: 219 GRFPNGKVKEPP--ILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVC 271
Score = 69.3 bits (168), Expect = 4e-12
Identities = 98/405 (24%), Positives = 140/405 (34%), Gaps = 111/405 (27%)
Query: 19 EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCE------YNFVSPSKSFWTRITC 72
E FC P IL + V G + Y+C+ NF+ +S + C
Sbjct: 272 EEIFCPSPP---PILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGES---TLRC 325
Query: 73 TEEG-----WS-PTPKC-----LRLCFFPFVENGHSESSGQT-HLEGDTVQIICNTGYRL 120
T + WS P P+C C P + G S + + DTV C G+ L
Sbjct: 326 TVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTL 385
Query: 121 QNNENNISCVERGWSTP--PKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRS 178
+ ++ I C +G P P C + C PP + N R M ++ G ++Y C
Sbjct: 386 KGSKQ-IRCNAQGTWEPSAPVC---EKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNP 441
Query: 179 PYEMFGDEEVMCLN-GNWTEP-PQCK----DSTGK------------------------- 207
Y + G+E + C + G WT P PQCK ++TG+
Sbjct: 442 GYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKL 501
Query: 208 -------------------------CGPPPPIDNGDITSFPLSVYAPASSVEYQCQN--- 239
C PPP I NG T L + ++V Y C
Sbjct: 502 SGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPE 561
Query: 240 ---LYQLEGNKRITC-----RNGQWSEP-PKCLHPCVISR----EIMENYNIALRWTAKQ 286
+ L G I C G WS P P C + + I Y I + K+
Sbjct: 562 RGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKI----SGKE 617
Query: 287 KLYLRTGESAEFVCKRGYRL--SSRSHTLRTTCWDGKLEYPTCAK 329
Y ++ F C G+ L SS+ WD E P C K
Sbjct: 618 APYF-YNDTVTFKCYSGFTLKGSSQIRCKADNTWDP--EIPVCEK 659
Score = 67.8 bits (164), Expect = 1e-11
Identities = 67/247 (27%), Positives = 104/247 (42%), Gaps = 43/247 (17%)
Query: 90 PFVENG-HSESSGQTHLEGDTVQIICNTGYRLQNN-----ENNISCV----ERG-WSTP- 137
P + NG H+ SS + G TV CN G E+ I C ERG WS P
Sbjct: 531 PVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPA 590
Query: 138 PKCR----STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNG 193
P C+ + S V+ + N + +S + + Y + V ++C S + + G ++ C
Sbjct: 591 PLCKLSLLAVQCSHVH---IANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKAD 647
Query: 194 NWTEP--PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC 251
N +P P C+ C PP + +G T + +V+Y C Y L GNK I C
Sbjct: 648 NTWDPEIPVCEKG---CQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHC 704
Query: 252 R-NGQWS-EPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFV---CKRGYRL 306
+G WS P+C C R+ ++ L G E V C+ GY+L
Sbjct: 705 MPSGNWSPSAPRCEETCQHVRQSLQE--------------LPAGSRVELVNTSCQDGYQL 750
Query: 307 SSRSHTL 313
+ ++ +
Sbjct: 751 TGHAYQM 757
Score = 64.3 bits (155), Expect = 1e-10
Identities = 62/257 (24%), Positives = 105/257 (40%), Gaps = 35/257 (13%)
Query: 67 WTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNN--- 123
WT++ EE + P+P P + H +S G V C+ N
Sbjct: 265 WTKMPVCEEIFCPSPP-------PILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFIL 317
Query: 124 --ENNISCVERG-----WSTP-PKCRSTDTSCVNP-PTVQNAHILSRQMSKYPSGERVRY 174
E+ + C WS P P+C + ++ P P + ++S Q +Y + V +
Sbjct: 318 IGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIF 377
Query: 175 ECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVE 234
C + + G +++ C N T P +C PP I NG + + P +S++
Sbjct: 378 ACMFGFTLKGSKQIRC-NAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIK 436
Query: 235 YQCQNLYQLEGNKRITCRN-GQWSEP-PKC-LHPC-VISREIMENYNIALRWTAKQKLYL 290
Y C Y L G + I C + G W+ P P+C + C R+++ T Q ++
Sbjct: 437 YSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLL---------TKPQHQFV 487
Query: 291 RTGESAEFVCKRGYRLS 307
R ++ C GY+LS
Sbjct: 488 RPDVNSS--CGEGYKLS 502
Score = 46.6 bits (109), Expect = 3e-05
Identities = 35/133 (26%), Positives = 56/133 (42%), Gaps = 22/133 (16%)
Query: 208 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-----RNGQWSEP-PK 261
CG PPPI NG I+ + + A + + Y C ++L G K + C +G W +P PK
Sbjct: 23 CGSPPPILNGRISYYSTPI-AVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
Query: 262 CLHPCVISREIMENYN------IALRWTAKQKLYLRTGESAEFVCKRGYRLS-SRSHTLR 314
C E Y+ + + + R G+S F CK + ++ ++S +
Sbjct: 82 C--------EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
Query: 315 TTCWDGKLEYPTC 327
G PTC
Sbjct: 134 ANNMWGPTRLPTC 146
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 76.3 bits (186), Expect = 4e-14
Identities = 79/284 (27%), Positives = 115/284 (40%), Gaps = 42/284 (14%)
Query: 53 YSCE--YNFVSPSKSFWTRITCTEEG----W-SPTPKCLRLC--FFPFVENGHSESSGQT 103
YSC Y + S + TC G W + TP C R+ P + NG S +
Sbjct: 121 YSCPKGYRLIGSSSA-----TCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Query: 104 HLE-GDTVQIICNTGYRLQN-----NENNISCVERG-----WSTP-PKCRSTDTSCVNPP 151
+ G V CN G R + E +I C + WS P P+C C PP
Sbjct: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC-IIPNKCT-PP 233
Query: 152 TVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEP--PQCKDSTGKCG 209
V+N ++S S + E V + C+ + M G V C N EP P C + C
Sbjct: 234 NVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSC---SRVCQ 290
Query: 210 PPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC-LHPC 266
PPP + + + T ++P V Y C+ Y L G+ + C G WS P+C + C
Sbjct: 291 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSC 350
Query: 267 VISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRS 310
+ N ++ L L+ G +FVC G++L S
Sbjct: 351 DDFLGQLPNGHVLF------PLNLQLGAKVDFVCDEGFQLKGSS 388
Score = 72.0 bits (175), Expect = 7e-13
Identities = 74/261 (28%), Positives = 109/261 (41%), Gaps = 38/261 (14%)
Query: 32 ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPT-PKC-LRLC- 87
+L+ E + G+ +YSCE + ++ + CT +G WSP P+C ++ C
Sbjct: 295 VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTY---LHCTPQGDWSPAAPRCEVKSCD 351
Query: 88 -FFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----W-STPPKCR 141
F + NGH L G V +C+ G++L+ + + CV G W S+ P C
Sbjct: 352 DFLGQLPNGHVLFPLNLQL-GAKVDFVCDEGFQLKGSSASY-CVLAGMESLWNSSVPVCE 409
Query: 142 STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMC-LNGN---WT- 196
SC PP N + ++ G R+ Y C + + + G C L+GN W+
Sbjct: 410 RK--SCETPPVPVNGMV--HVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSM 465
Query: 197 EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGNKRIT 250
+PP C+ C PP I NG T PL V Y C + L G I
Sbjct: 466 KPPICQQIF--CPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIR 523
Query: 251 CR-----NGQWSEP-PKCLHP 265
NG WS P P+C P
Sbjct: 524 RTSEPHGNGVWSSPAPRCELP 544
Score = 70.9 bits (172), Expect = 2e-12
Identities = 62/235 (26%), Positives = 96/235 (40%), Gaps = 31/235 (13%)
Query: 114 CNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQN--AHILSRQMSKYPSGER 171
C GY +I C++ T K + SC NPP N AH++ + +
Sbjct: 65 CRPGY--SGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFR----SQ 118
Query: 172 VRYECRSPYEMFGDEEVMC-LNGN---W-TEPPQCKDSTGKCGPPPPIDNGDITSFPLSV 226
++Y C Y + G C ++GN W + P C CG PP I NGD TS
Sbjct: 119 IKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRII--CGLPPTIANGDFTSISREY 176
Query: 227 YAPASSVEYQC------QNLYQLEGNKRITCRN-----GQWSEP-PKCLHPCVISREIME 274
+ S V Y C + +++L G I C + G WS P P+C+ P + +E
Sbjct: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVE 236
Query: 275 NYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAK 329
N + + + E EF C+ G+ + SH + E P+C++
Sbjct: 237 NGIL----VSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSR 287
Score = 43.9 bits (102), Expect = 2e-04
Identities = 50/195 (25%), Positives = 76/195 (38%), Gaps = 36/195 (18%)
Query: 44 QVPTGEVFY-----------YSCEYNF-VSPSKSFWTRITCTEEGW-SPTPKCLRL-CFF 89
Q+P G V + + C+ F + S + + + E W S P C R C
Sbjct: 356 QLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCET 415
Query: 90 PFVE-NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----WST-PPKCRST 143
P V NG H+ G + C TG+RL + ++ C+ G WS PP C+
Sbjct: 416 PPVPVNGMVHVITDIHV-GSRINYSCTTGHRLIGH-SSAECILSGNTAHWSMKPPICQQI 473
Query: 144 DTSCVNPPTVQNAHILSRQMSKYPSGERVRYEC------RSPYEMFGDEEVMCL-----N 192
C NPP + N + P G+ V Y C + + G+ + N
Sbjct: 474 --FCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGN 531
Query: 193 GNWTEP-PQCKDSTG 206
G W+ P P+C+ G
Sbjct: 532 GVWSSPAPRCELPVG 546
Score = 35.8 bits (81), Expect = 0.054
Identities = 25/88 (28%), Positives = 37/88 (42%), Gaps = 5/88 (5%)
Query: 165 KYPSGERVRYECRSPYEMFGDEEVMCLNGNWTE-PPQCKDSTGKCGPPPPIDNGDITSFP 223
++P G + YECR Y + N WT +CK + C PP NG +
Sbjct: 54 EFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRKS--CRNPPDPVNG--MAHV 109
Query: 224 LSVYAPASSVEYQCQNLYQLEGNKRITC 251
+ S ++Y C Y+L G+ TC
Sbjct: 110 IKDIQFRSQIKYSCPKGYRLIGSSSATC 137
>gi|4502503 complement component 4 binding protein, alpha chain
precursor [Homo sapiens]
Length = 597
Score = 75.1 bits (183), Expect = 8e-14
Identities = 59/195 (30%), Positives = 90/195 (46%), Gaps = 17/195 (8%)
Query: 17 GGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG 76
G EA C PK+N+G + K +P + V++Y E +F S ++ I +
Sbjct: 359 GCEALCCPEPKLNNGEITQHRKSRPANHC----VYFYGDEISFSCHETSRFSAICQGDGT 414
Query: 77 WSP-TPKCLRLCFF-PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
WSP TP C +C F P + +GH + S + + C+ GY L + +SC W
Sbjct: 415 WSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILV-GQAKLSCSYSHW 473
Query: 135 STP-PKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNG 193
S P P+C++ C P V LS +Y E V +C S Y + G + + C +G
Sbjct: 474 SAPAPQCKAL---CRKPELVNGR--LSVDKDQYVEPENVTIQCDSGYGVVGPQSITC-SG 527
Query: 194 NWT---EPPQCKDST 205
N T E P+C+ T
Sbjct: 528 NRTWYPEVPKCEWET 542
Score = 67.4 bits (163), Expect = 2e-11
Identities = 66/229 (28%), Positives = 94/229 (41%), Gaps = 29/229 (12%)
Query: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEE-GWSPTPKCLRLCF-FPFVENG----HSESSG 101
G V Y C + P+ T + C + W+P C LC P + NG H +S
Sbjct: 325 GTVLRYRCHPGY-KPTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRP 383
Query: 102 QTH---LEGDTVQIICNTGYRLQNNENNISCVERG-WSTPPKCRSTDTSCVNPPTVQNAH 157
H GD + C+ R + C G WS P+ S C PP + + H
Sbjct: 384 ANHCVYFYGDEISFSCHETSRF-----SAICQGDGTWS--PRTPSCGDICNFPPKIAHGH 436
Query: 158 ILSRQMSKYPS-GERVRYECRSPYEMFGDEEVMCLNGNWTEP-PQCKDSTGKCGPPPPID 215
+Q S Y E + YEC Y + G ++ C +W+ P PQCK K P +
Sbjct: 437 Y--KQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRK----PELV 490
Query: 216 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQ--WSEPPKC 262
NG + S Y +V QC + Y + G + ITC + + E PKC
Sbjct: 491 NGRL-SVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
Score = 63.5 bits (153), Expect = 2e-10
Identities = 65/275 (23%), Positives = 111/275 (40%), Gaps = 26/275 (9%)
Query: 47 TGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPTPKCL-RLCFFPF-VENGHSESSGQT 103
TG Y+C +V + +TC +G W C+ + C P + NG E
Sbjct: 73 TGTTLKYTCLPGYVRSHST--QTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDL 130
Query: 104 HLEGDTVQIICNTGYRLQNNENNISCVER---GWSTP-PKCRSTDTSCVNPPTVQNAHIL 159
G ++ C+ G+ L + + V+ GWS P P+C C PP ++N
Sbjct: 131 SF-GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIV--KCKPPPDIRNGRH- 186
Query: 160 SRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWT------EPPQCKDSTGKCGPPPP 213
S + + Y G V Y C + + G + C N T PP C+ T + P
Sbjct: 187 SGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCR---KPD 243
Query: 214 IDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEPPKCLHP--CVISR 270
+ +G++ S +Y ++ ++CQ + L G+ I C + +W+ P P C+
Sbjct: 244 VSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLP 303
Query: 271 EIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYR 305
+I K+ +Y+ G + C GY+
Sbjct: 304 DIPHASWETYPRPTKEDVYV-VGTVLRYRCHPGYK 337
Score = 30.4 bits (67), Expect = 2.3
Identities = 26/106 (24%), Positives = 44/106 (41%), Gaps = 12/106 (11%)
Query: 206 GKCGPPPPIDNG---DITSFPLSVYAPASSVEYQCQNLY-QLEGNKRITCR-NGQWSEPP 260
G CGPPP + DIT + + ++++Y C Y + + +TC +G+W
Sbjct: 48 GNCGPPPTLSFAAPMDIT-LTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT 106
Query: 261 KCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 306
C++ + N + + K L G EF C G+ L
Sbjct: 107 FCIYKRCRHPGELRNGQVEI------KTDLSFGSQIEFSCSEGFFL 146
>gi|168693643 decay accelerating factor for complement isoform 2
precursor [Homo sapiens]
Length = 440
Score = 71.2 bits (173), Expect = 1e-12
Identities = 67/234 (28%), Positives = 99/234 (42%), Gaps = 28/234 (11%)
Query: 46 PTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK-CLRLCFFPFVENGHSESSGQTH 104
P V Y CE +FV + I WS + C R C P N S S Q +
Sbjct: 56 PEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLN--SASLKQPY 113
Query: 105 LE------GDTVQIICNTGYRLQNNEN-NISCVER-GWSTPPK-CRSTDTSCVNPPTVQN 155
+ G V+ C GYR + + + ++C++ WST + C+ SC NP ++N
Sbjct: 114 ITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKK--SCPNPGEIRN 171
Query: 156 AHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL----NGNWTEP-PQCKDSTGKCGP 210
I + G + + C + Y++FG CL + W++P P+C++ C
Sbjct: 172 GQIDVPGGILF--GATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY--CPA 227
Query: 211 PPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR----NGQWSEPP 260
PP IDNG I Y SV Y C + + G I C G+WS PP
Sbjct: 228 PPQIDNGIIQG-ERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPP 280
Score = 68.6 bits (166), Expect = 8e-12
Identities = 60/225 (26%), Positives = 97/225 (43%), Gaps = 25/225 (11%)
Query: 23 CDFP-KINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV-SPSKSFWTRITCTEE-GWSP 79
C+ P ++N L ++ Y + P G V Y C + PS S ++TC + WS
Sbjct: 98 CEVPTRLNSASL--KQPYITQNYFPVGTVVEYECRPGYRREPSLS--PKLTCLQNLKWST 153
Query: 80 TPKCLRLCFFPF---VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG--- 133
+ + P + NG + G L G T+ CNTGY+L + ++ C+ G
Sbjct: 154 AVEFCKKKSCPNPGEIRNGQIDVPGGI-LFGATISFSCNTGYKLFGSTSSF-CLISGSSV 211
Query: 134 -WSTP-PKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL 191
WS P P+CR + C PP + N I+ + Y + V Y C + M G+ + C
Sbjct: 212 QWSDPLPECR--EIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCT 268
Query: 192 ----NGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPAS 231
G W+ PP+C+ + PP + + P + +P S
Sbjct: 269 VNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTS 313
Score = 38.9 bits (89), Expect = 0.006
Identities = 35/151 (23%), Positives = 63/151 (41%), Gaps = 23/151 (15%)
Query: 188 VMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLY-QLEGN 246
++CL W G CG PP + N + + + + Y+C+ + ++ G
Sbjct: 26 LLCLPAVW----------GDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGE 75
Query: 247 K-RITCRNG-QWSEPPK-CLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRG 303
K + C G QWS+ + C C + + + +L+ + Y G E+ C+ G
Sbjct: 76 KDSVICLKGSQWSDIEEFCNRSCEVPTRL---NSASLKQPYITQNYFPVGTVVEYECRPG 132
Query: 304 YR----LSSRSHTLRTTCWDGKLEYPTCAKR 330
YR LS + L+ W +E+ C K+
Sbjct: 133 YRREPSLSPKLTCLQNLKWSTAVEF--CKKK 161
Score = 37.7 bits (86), Expect = 0.014
Identities = 32/120 (26%), Positives = 57/120 (47%), Gaps = 12/120 (10%)
Query: 147 CVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEE--VMCLNGN-WTEPPQ-CK 202
C PP V NA + +P + Y+C + E+ V+CL G+ W++ + C
Sbjct: 36 CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
Query: 203 DSTGKCGPPPPIDNGDITS-FPLSVYAPASS-VEYQCQNLYQLEG--NKRITC-RNGQWS 257
S C P +++ + + Y P + VEY+C+ Y+ E + ++TC +N +WS
Sbjct: 96 RS---CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWS 152
>gi|10835143 decay accelerating factor for complement isoform 1
preproprotein [Homo sapiens]
Length = 381
Score = 71.2 bits (173), Expect = 1e-12
Identities = 67/234 (28%), Positives = 99/234 (42%), Gaps = 28/234 (11%)
Query: 46 PTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK-CLRLCFFPFVENGHSESSGQTH 104
P V Y CE +FV + I WS + C R C P N S S Q +
Sbjct: 56 PEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLN--SASLKQPY 113
Query: 105 LE------GDTVQIICNTGYRLQNNEN-NISCVER-GWSTPPK-CRSTDTSCVNPPTVQN 155
+ G V+ C GYR + + + ++C++ WST + C+ SC NP ++N
Sbjct: 114 ITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKK--SCPNPGEIRN 171
Query: 156 AHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL----NGNWTEP-PQCKDSTGKCGP 210
I + G + + C + Y++FG CL + W++P P+C++ C
Sbjct: 172 GQIDVPGGILF--GATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY--CPA 227
Query: 211 PPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR----NGQWSEPP 260
PP IDNG I Y SV Y C + + G I C G+WS PP
Sbjct: 228 PPQIDNGIIQG-ERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPP 280
Score = 68.6 bits (166), Expect = 8e-12
Identities = 60/225 (26%), Positives = 97/225 (43%), Gaps = 25/225 (11%)
Query: 23 CDFP-KINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV-SPSKSFWTRITCTEE-GWSP 79
C+ P ++N L ++ Y + P G V Y C + PS S ++TC + WS
Sbjct: 98 CEVPTRLNSASL--KQPYITQNYFPVGTVVEYECRPGYRREPSLS--PKLTCLQNLKWST 153
Query: 80 TPKCLRLCFFPF---VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG--- 133
+ + P + NG + G L G T+ CNTGY+L + ++ C+ G
Sbjct: 154 AVEFCKKKSCPNPGEIRNGQIDVPGGI-LFGATISFSCNTGYKLFGSTSSF-CLISGSSV 211
Query: 134 -WSTP-PKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL 191
WS P P+CR + C PP + N I+ + Y + V Y C + M G+ + C
Sbjct: 212 QWSDPLPECR--EIYCPAPPQIDNG-IIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCT 268
Query: 192 ----NGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPAS 231
G W+ PP+C+ + PP + + P + +P S
Sbjct: 269 VNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTS 313
Score = 38.9 bits (89), Expect = 0.006
Identities = 35/151 (23%), Positives = 63/151 (41%), Gaps = 23/151 (15%)
Query: 188 VMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLY-QLEGN 246
++CL W G CG PP + N + + + + Y+C+ + ++ G
Sbjct: 26 LLCLPAVW----------GDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGE 75
Query: 247 K-RITCRNG-QWSEPPK-CLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRG 303
K + C G QWS+ + C C + + + +L+ + Y G E+ C+ G
Sbjct: 76 KDSVICLKGSQWSDIEEFCNRSCEVPTRL---NSASLKQPYITQNYFPVGTVVEYECRPG 132
Query: 304 YR----LSSRSHTLRTTCWDGKLEYPTCAKR 330
YR LS + L+ W +E+ C K+
Sbjct: 133 YRREPSLSPKLTCLQNLKWSTAVEF--CKKK 161
Score = 37.7 bits (86), Expect = 0.014
Identities = 32/120 (26%), Positives = 57/120 (47%), Gaps = 12/120 (10%)
Query: 147 CVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEE--VMCLNGN-WTEPPQ-CK 202
C PP V NA + +P + Y+C + E+ V+CL G+ W++ + C
Sbjct: 36 CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCN 95
Query: 203 DSTGKCGPPPPIDNGDITS-FPLSVYAPASS-VEYQCQNLYQLEG--NKRITC-RNGQWS 257
S C P +++ + + Y P + VEY+C+ Y+ E + ++TC +N +WS
Sbjct: 96 RS---CEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWS 152
>gi|187960042 selectin E precursor [Homo sapiens]
Length = 610
Score = 68.9 bits (167), Expect = 6e-12
Identities = 61/225 (27%), Positives = 91/225 (40%), Gaps = 16/225 (7%)
Query: 112 IICNTGYRLQNNENNISCVERG-WSTP-PKCRSTDTSCVNPPTVQNAHILSRQMSKYPSG 169
I C+ GY L ++ + C+ G WS P P C + V P S +P
Sbjct: 208 ISCDRGY-LPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGS-FPWN 265
Query: 170 ERVRYECRSPYEMFGDEEVMCLN-GNW-TEPPQCKDSTGKCGPPPPIDNGDITSFPLSVY 227
++C +E+ G + + C + GNW E P CK T + P + + P +
Sbjct: 266 TTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEF 325
Query: 228 APASSVEYQCQNLYQLEGNKRITC-RNGQWSEP-PKC-LHPCVISREIMENYNIALRWTA 284
SS + C+ + L+G ++ C GQW++ P C C Y L +
Sbjct: 326 TFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSAS 385
Query: 285 KQKLYLRTGESAEFVCKRGYRL--SSRSHTLRTTCWDGKLEYPTC 327
R G S EF C++G+ L S R T WD E PTC
Sbjct: 386 GS---FRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDN--EKPTC 425
>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
precursor [Homo sapiens]
Length = 373
Score = 65.5 bits (158), Expect = 6e-11
Identities = 69/248 (27%), Positives = 104/248 (41%), Gaps = 34/248 (13%)
Query: 38 KYKPFSQVPTGEVFYYSCE--YNFVSPSKSFWTRITCTEEGWSPTPK--CLR-LCFFPFV 92
K KP+ ++ GE Y C+ Y ++ P + I W P C R C P++
Sbjct: 49 KPKPYYEI--GERVDYKCKKGYFYIPPLATH--TICDRNHTWLPVSDDACYRETC--PYI 102
Query: 93 E---NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----WS-TPPKCRSTD 144
NG + + T+ G + ICN GY L E + C +G WS PP C
Sbjct: 103 RDPLNGQAVPANGTYEFGYQMHFICNEGYYL-IGEEILYCELKGSVAIWSGKPPICEK-- 159
Query: 145 TSCVNPPTVQNAHILSRQMSKYPSGERVRYEC-----RSPYEMFGDEEVMC-LNGNWTE- 197
C PP ++N ++ + + V Y C P+ + G+ + C N W+
Sbjct: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRA 219
Query: 198 PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQW 256
P+CK KC P + I+ F Y A +V ++C + L+G+ I C N W
Sbjct: 220 APECK--VVKCRFPVVENGKQISGFGKKFYYKA-TVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 257 SEP-PKCL 263
P PKCL
Sbjct: 277 DPPVPKCL 284
Score = 47.4 bits (111), Expect = 2e-05
Identities = 49/184 (26%), Positives = 76/184 (41%), Gaps = 35/184 (19%)
Query: 166 YPSGERVRYECRSPYEMFGDEEVMC-LNGN---WT-EPPQCKDSTGKCGPPPPIDNGDIT 220
Y G ++ + C Y + G+E + C L G+ W+ +PP C+ C PPP I NG T
Sbjct: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVL--CTPPPKIKNGKHT 174
Query: 221 SFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC-RNGQWSEPP------KCLHPCVI 268
+ V+ +V Y C + + L G I C N WS KC P V
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVE 234
Query: 269 SREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTL---RTTCWDGKLEYP 325
+ + + + +K Y + + F C +G+ L S T+ + WD + P
Sbjct: 235 NGKQISGFG--------KKFYYKA--TVMFECDKGFYLDG-SDTIVCDSNSTWDPPV--P 281
Query: 326 TCAK 329
C K
Sbjct: 282 KCLK 285
Score = 32.7 bits (73), Expect = 0.46
Identities = 13/39 (33%), Positives = 20/39 (51%)
Query: 142 STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180
S +C PPT + ++ + Y GERV Y+C+ Y
Sbjct: 30 SFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY 68
Score = 30.8 bits (68), Expect = 1.7
Identities = 31/114 (27%), Positives = 45/114 (39%), Gaps = 12/114 (10%)
Query: 124 ENNISCVERG-WS-TPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYE 181
E+ I C + WS P+C+ P V+N +S K+ V +EC +
Sbjct: 205 ESTIYCGDNSVWSRAAPECKVVKCRF---PVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 182 MFGDEEVMC-LNGNWTEP-PQC-KDSTGKCGPPPPIDNGDITSFPLSVYAPASS 232
+ G + ++C N W P P+C K ST P S P Y P S
Sbjct: 262 LDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSP----ASSASGPRPTYKPPVS 311
>gi|27502419 CD46 antigen, complement regulatory protein isoform 11
precursor [Homo sapiens]
Length = 348
Score = 65.5 bits (158), Expect = 6e-11
Identities = 69/248 (27%), Positives = 104/248 (41%), Gaps = 34/248 (13%)
Query: 38 KYKPFSQVPTGEVFYYSCE--YNFVSPSKSFWTRITCTEEGWSPTPK--CLR-LCFFPFV 92
K KP+ ++ GE Y C+ Y ++ P + I W P C R C P++
Sbjct: 49 KPKPYYEI--GERVDYKCKKGYFYIPPLATH--TICDRNHTWLPVSDDACYRETC--PYI 102
Query: 93 E---NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----WS-TPPKCRSTD 144
NG + + T+ G + ICN GY L E + C +G WS PP C
Sbjct: 103 RDPLNGQAVPANGTYEFGYQMHFICNEGYYL-IGEEILYCELKGSVAIWSGKPPICEK-- 159
Query: 145 TSCVNPPTVQNAHILSRQMSKYPSGERVRYEC-----RSPYEMFGDEEVMC-LNGNWTE- 197
C PP ++N ++ + + V Y C P+ + G+ + C N W+
Sbjct: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRA 219
Query: 198 PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQW 256
P+CK KC P + I+ F Y A +V ++C + L+G+ I C N W
Sbjct: 220 APECK--VVKCRFPVVENGKQISGFGKKFYYKA-TVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 257 SEP-PKCL 263
P PKCL
Sbjct: 277 DPPVPKCL 284
Score = 47.4 bits (111), Expect = 2e-05
Identities = 49/184 (26%), Positives = 76/184 (41%), Gaps = 35/184 (19%)
Query: 166 YPSGERVRYECRSPYEMFGDEEVMC-LNGN---WT-EPPQCKDSTGKCGPPPPIDNGDIT 220
Y G ++ + C Y + G+E + C L G+ W+ +PP C+ C PPP I NG T
Sbjct: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVL--CTPPPKIKNGKHT 174
Query: 221 SFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC-RNGQWSEPP------KCLHPCVI 268
+ V+ +V Y C + + L G I C N WS KC P V
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVE 234
Query: 269 SREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTL---RTTCWDGKLEYP 325
+ + + + +K Y + + F C +G+ L S T+ + WD + P
Sbjct: 235 NGKQISGFG--------KKFYYKA--TVMFECDKGFYLDG-SDTIVCDSNSTWDPPV--P 281
Query: 326 TCAK 329
C K
Sbjct: 282 KCLK 285
Score = 32.7 bits (73), Expect = 0.46
Identities = 13/39 (33%), Positives = 20/39 (51%)
Query: 142 STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180
S +C PPT + ++ + Y GERV Y+C+ Y
Sbjct: 30 SFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY 68
Score = 30.0 bits (66), Expect = 3.0
Identities = 29/117 (24%), Positives = 48/117 (41%), Gaps = 6/117 (5%)
Query: 124 ENNISCVERG-WS-TPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYE 181
E+ I C + WS P+C+ P V+N +S K+ V +EC +
Sbjct: 205 ESTIYCGDNSVWSRAAPECKVVKCRF---PVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 182 MFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPI-DNGDITSFPLSVYAPASSVEYQC 237
+ G + ++C + + +PP K G P I D+ D+ + V A V C
Sbjct: 262 LDGSDTIVCDSNSTWDPPVPKCLKGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVIC 318
>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
precursor [Homo sapiens]
Length = 370
Score = 65.5 bits (158), Expect = 6e-11
Identities = 69/248 (27%), Positives = 104/248 (41%), Gaps = 34/248 (13%)
Query: 38 KYKPFSQVPTGEVFYYSCE--YNFVSPSKSFWTRITCTEEGWSPTPK--CLR-LCFFPFV 92
K KP+ ++ GE Y C+ Y ++ P + I W P C R C P++
Sbjct: 49 KPKPYYEI--GERVDYKCKKGYFYIPPLATH--TICDRNHTWLPVSDDACYRETC--PYI 102
Query: 93 E---NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----WS-TPPKCRSTD 144
NG + + T+ G + ICN GY L E + C +G WS PP C
Sbjct: 103 RDPLNGQAVPANGTYEFGYQMHFICNEGYYL-IGEEILYCELKGSVAIWSGKPPICEK-- 159
Query: 145 TSCVNPPTVQNAHILSRQMSKYPSGERVRYEC-----RSPYEMFGDEEVMC-LNGNWTE- 197
C PP ++N ++ + + V Y C P+ + G+ + C N W+
Sbjct: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRA 219
Query: 198 PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQW 256
P+CK KC P + I+ F Y A +V ++C + L+G+ I C N W
Sbjct: 220 APECK--VVKCRFPVVENGKQISGFGKKFYYKA-TVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 257 SEP-PKCL 263
P PKCL
Sbjct: 277 DPPVPKCL 284
Score = 47.4 bits (111), Expect = 2e-05
Identities = 49/184 (26%), Positives = 76/184 (41%), Gaps = 35/184 (19%)
Query: 166 YPSGERVRYECRSPYEMFGDEEVMC-LNGN---WT-EPPQCKDSTGKCGPPPPIDNGDIT 220
Y G ++ + C Y + G+E + C L G+ W+ +PP C+ C PPP I NG T
Sbjct: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVL--CTPPPKIKNGKHT 174
Query: 221 SFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC-RNGQWSEPP------KCLHPCVI 268
+ V+ +V Y C + + L G I C N WS KC P V
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVE 234
Query: 269 SREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTL---RTTCWDGKLEYP 325
+ + + + +K Y + + F C +G+ L S T+ + WD + P
Sbjct: 235 NGKQISGFG--------KKFYYKA--TVMFECDKGFYLDG-SDTIVCDSNSTWDPPV--P 281
Query: 326 TCAK 329
C K
Sbjct: 282 KCLK 285
Score = 32.7 bits (73), Expect = 0.46
Identities = 13/39 (33%), Positives = 20/39 (51%)
Query: 142 STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180
S +C PPT + ++ + Y GERV Y+C+ Y
Sbjct: 30 SFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY 68
Score = 30.0 bits (66), Expect = 3.0
Identities = 26/94 (27%), Positives = 40/94 (42%), Gaps = 8/94 (8%)
Query: 124 ENNISCVERG-WS-TPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYE 181
E+ I C + WS P+C+ P V+N +S K+ V +EC +
Sbjct: 205 ESTIYCGDNSVWSRAAPECKVVKCRF---PVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 182 MFGDEEVMC-LNGNWTEP-PQC-KDSTGKCGPPP 212
+ G + ++C N W P P+C K ST P
Sbjct: 262 LDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSP 295
>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
precursor [Homo sapiens]
Length = 363
Score = 65.5 bits (158), Expect = 6e-11
Identities = 69/248 (27%), Positives = 104/248 (41%), Gaps = 34/248 (13%)
Query: 38 KYKPFSQVPTGEVFYYSCE--YNFVSPSKSFWTRITCTEEGWSPTPK--CLR-LCFFPFV 92
K KP+ ++ GE Y C+ Y ++ P + I W P C R C P++
Sbjct: 49 KPKPYYEI--GERVDYKCKKGYFYIPPLATH--TICDRNHTWLPVSDDACYRETC--PYI 102
Query: 93 E---NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----WS-TPPKCRSTD 144
NG + + T+ G + ICN GY L E + C +G WS PP C
Sbjct: 103 RDPLNGQAVPANGTYEFGYQMHFICNEGYYL-IGEEILYCELKGSVAIWSGKPPICEK-- 159
Query: 145 TSCVNPPTVQNAHILSRQMSKYPSGERVRYEC-----RSPYEMFGDEEVMC-LNGNWTE- 197
C PP ++N ++ + + V Y C P+ + G+ + C N W+
Sbjct: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRA 219
Query: 198 PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQW 256
P+CK KC P + I+ F Y A +V ++C + L+G+ I C N W
Sbjct: 220 APECK--VVKCRFPVVENGKQISGFGKKFYYKA-TVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 257 SEP-PKCL 263
P PKCL
Sbjct: 277 DPPVPKCL 284
Score = 47.4 bits (111), Expect = 2e-05
Identities = 49/184 (26%), Positives = 76/184 (41%), Gaps = 35/184 (19%)
Query: 166 YPSGERVRYECRSPYEMFGDEEVMC-LNGN---WT-EPPQCKDSTGKCGPPPPIDNGDIT 220
Y G ++ + C Y + G+E + C L G+ W+ +PP C+ C PPP I NG T
Sbjct: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVL--CTPPPKIKNGKHT 174
Query: 221 SFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC-RNGQWSEPP------KCLHPCVI 268
+ V+ +V Y C + + L G I C N WS KC P V
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVE 234
Query: 269 SREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTL---RTTCWDGKLEYP 325
+ + + + +K Y + + F C +G+ L S T+ + WD + P
Sbjct: 235 NGKQISGFG--------KKFYYKA--TVMFECDKGFYLDG-SDTIVCDSNSTWDPPV--P 281
Query: 326 TCAK 329
C K
Sbjct: 282 KCLK 285
Score = 32.7 bits (73), Expect = 0.46
Identities = 13/39 (33%), Positives = 20/39 (51%)
Query: 142 STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180
S +C PPT + ++ + Y GERV Y+C+ Y
Sbjct: 30 SFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY 68
Score = 30.0 bits (66), Expect = 3.0
Identities = 26/94 (27%), Positives = 40/94 (42%), Gaps = 8/94 (8%)
Query: 124 ENNISCVERG-WS-TPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYE 181
E+ I C + WS P+C+ P V+N +S K+ V +EC +
Sbjct: 205 ESTIYCGDNSVWSRAAPECKVVKCRF---PVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 182 MFGDEEVMC-LNGNWTEP-PQC-KDSTGKCGPPP 212
+ G + ++C N W P P+C K ST P
Sbjct: 262 LDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSP 295
>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
precursor [Homo sapiens]
Length = 378
Score = 65.5 bits (158), Expect = 6e-11
Identities = 69/248 (27%), Positives = 104/248 (41%), Gaps = 34/248 (13%)
Query: 38 KYKPFSQVPTGEVFYYSCE--YNFVSPSKSFWTRITCTEEGWSPTPK--CLR-LCFFPFV 92
K KP+ ++ GE Y C+ Y ++ P + I W P C R C P++
Sbjct: 49 KPKPYYEI--GERVDYKCKKGYFYIPPLATH--TICDRNHTWLPVSDDACYRETC--PYI 102
Query: 93 E---NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----WS-TPPKCRSTD 144
NG + + T+ G + ICN GY L E + C +G WS PP C
Sbjct: 103 RDPLNGQAVPANGTYEFGYQMHFICNEGYYL-IGEEILYCELKGSVAIWSGKPPICEK-- 159
Query: 145 TSCVNPPTVQNAHILSRQMSKYPSGERVRYEC-----RSPYEMFGDEEVMC-LNGNWTE- 197
C PP ++N ++ + + V Y C P+ + G+ + C N W+
Sbjct: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRA 219
Query: 198 PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQW 256
P+CK KC P + I+ F Y A +V ++C + L+G+ I C N W
Sbjct: 220 APECK--VVKCRFPVVENGKQISGFGKKFYYKA-TVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 257 SEP-PKCL 263
P PKCL
Sbjct: 277 DPPVPKCL 284
Score = 47.4 bits (111), Expect = 2e-05
Identities = 49/184 (26%), Positives = 76/184 (41%), Gaps = 35/184 (19%)
Query: 166 YPSGERVRYECRSPYEMFGDEEVMC-LNGN---WT-EPPQCKDSTGKCGPPPPIDNGDIT 220
Y G ++ + C Y + G+E + C L G+ W+ +PP C+ C PPP I NG T
Sbjct: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVL--CTPPPKIKNGKHT 174
Query: 221 SFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC-RNGQWSEPP------KCLHPCVI 268
+ V+ +V Y C + + L G I C N WS KC P V
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVE 234
Query: 269 SREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTL---RTTCWDGKLEYP 325
+ + + + +K Y + + F C +G+ L S T+ + WD + P
Sbjct: 235 NGKQISGFG--------KKFYYKA--TVMFECDKGFYLDG-SDTIVCDSNSTWDPPV--P 281
Query: 326 TCAK 329
C K
Sbjct: 282 KCLK 285
Score = 32.7 bits (73), Expect = 0.46
Identities = 13/39 (33%), Positives = 20/39 (51%)
Query: 142 STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180
S +C PPT + ++ + Y GERV Y+C+ Y
Sbjct: 30 SFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY 68
Score = 31.6 bits (70), Expect = 1.0
Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 8/113 (7%)
Query: 124 ENNISCVERG-WS-TPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYE 181
E+ I C + WS P+C+ P V+N +S K+ V +EC +
Sbjct: 205 ESTIYCGDNSVWSRAAPECKVVKCRF---PVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 182 MFGDEEVMC-LNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASS 232
+ G + ++C N W P P+C PP + + S + +PASS
Sbjct: 262 LDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSV-STSSTTKSPASS 313
>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
precursor [Homo sapiens]
Length = 369
Score = 65.5 bits (158), Expect = 6e-11
Identities = 69/248 (27%), Positives = 104/248 (41%), Gaps = 34/248 (13%)
Query: 38 KYKPFSQVPTGEVFYYSCE--YNFVSPSKSFWTRITCTEEGWSPTPK--CLR-LCFFPFV 92
K KP+ ++ GE Y C+ Y ++ P + I W P C R C P++
Sbjct: 49 KPKPYYEI--GERVDYKCKKGYFYIPPLATH--TICDRNHTWLPVSDDACYRETC--PYI 102
Query: 93 E---NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----WS-TPPKCRSTD 144
NG + + T+ G + ICN GY L E + C +G WS PP C
Sbjct: 103 RDPLNGQAVPANGTYEFGYQMHFICNEGYYL-IGEEILYCELKGSVAIWSGKPPICEK-- 159
Query: 145 TSCVNPPTVQNAHILSRQMSKYPSGERVRYEC-----RSPYEMFGDEEVMC-LNGNWTE- 197
C PP ++N ++ + + V Y C P+ + G+ + C N W+
Sbjct: 160 VLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRA 219
Query: 198 PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQW 256
P+CK KC P + I+ F Y A +V ++C + L+G+ I C N W
Sbjct: 220 APECK--VVKCRFPVVENGKQISGFGKKFYYKA-TVMFECDKGFYLDGSDTIVCDSNSTW 276
Query: 257 SEP-PKCL 263
P PKCL
Sbjct: 277 DPPVPKCL 284
Score = 47.4 bits (111), Expect = 2e-05
Identities = 49/184 (26%), Positives = 76/184 (41%), Gaps = 35/184 (19%)
Query: 166 YPSGERVRYECRSPYEMFGDEEVMC-LNGN---WT-EPPQCKDSTGKCGPPPPIDNGDIT 220
Y G ++ + C Y + G+E + C L G+ W+ +PP C+ C PPP I NG T
Sbjct: 117 YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVL--CTPPPKIKNGKHT 174
Query: 221 SFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC-RNGQWSEPP------KCLHPCVI 268
+ V+ +V Y C + + L G I C N WS KC P V
Sbjct: 175 FSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVE 234
Query: 269 SREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTL---RTTCWDGKLEYP 325
+ + + + +K Y + + F C +G+ L S T+ + WD + P
Sbjct: 235 NGKQISGFG--------KKFYYKA--TVMFECDKGFYLDG-SDTIVCDSNSTWDPPV--P 281
Query: 326 TCAK 329
C K
Sbjct: 282 KCLK 285
Score = 32.7 bits (73), Expect = 0.46
Identities = 13/39 (33%), Positives = 20/39 (51%)
Query: 142 STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180
S +C PPT + ++ + Y GERV Y+C+ Y
Sbjct: 30 SFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY 68
Score = 30.4 bits (67), Expect = 2.3
Identities = 24/93 (25%), Positives = 38/93 (40%), Gaps = 7/93 (7%)
Query: 124 ENNISCVERG-WS-TPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYE 181
E+ I C + WS P+C+ P V+N +S K+ V +EC +
Sbjct: 205 ESTIYCGDNSVWSRAAPECKVVKCRF---PVVENGKQISGFGKKFYYKATVMFECDKGFY 261
Query: 182 MFGDEEVMC-LNGNWTEP-PQCKDSTGKCGPPP 212
+ G + ++C N W P P+C PP
Sbjct: 262 LDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPP 294
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.445
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,420,256
Number of Sequences: 37866
Number of extensions: 862782
Number of successful extensions: 2890
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 1886
Number of HSP's gapped (non-prelim): 546
length of query: 330
length of database: 18,247,518
effective HSP length: 103
effective length of query: 227
effective length of database: 14,347,320
effective search space: 3256841640
effective search space used: 3256841640
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.