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Search of human proteins with 239757989
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens]
(353 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens] 712 0.0
gi|21618349 mitogen-activated protein kinase kinase 3 isoform B ... 472 e-133
gi|21618347 mitogen-activated protein kinase kinase 3 isoform A ... 446 e-125
gi|14589900 mitogen-activated protein kinase kinase 6 [Homo sapi... 374 e-104
gi|239751247 PREDICTED: similar to mitogen-activated protein kin... 307 8e-84
gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens] 261 5e-70
gi|21735544 mitogen-activated protein kinase kinase 7 [Homo sapi... 192 5e-49
gi|13489054 mitogen-activated protein kinase kinase 2 [Homo sapi... 164 9e-41
gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens] 161 7e-40
gi|21729895 mitogen-activated protein kinase kinase 5 isoform A ... 150 2e-36
gi|4506101 mitogen-activated protein kinase kinase 5 isoform B [... 150 2e-36
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 125 7e-29
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 121 8e-28
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 104 1e-22
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 104 1e-22
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 101 1e-21
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 99 7e-21
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 98 1e-20
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 98 1e-20
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 98 1e-20
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 98 1e-20
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 97 2e-20
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 97 3e-20
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 97 3e-20
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 97 3e-20
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 97 3e-20
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 97 3e-20
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 97 3e-20
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 97 3e-20
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 97 3e-20
>gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens]
Length = 353
Score = 712 bits (1839), Expect = 0.0
Identities = 353/353 (100%), Positives = 353/353 (100%)
Query: 1 MGVQGTLMSRDGQTPHLLSTLGKSKRKKDLRISCMSKPPAPNPTTPRNLDSRTFITIGDT 60
MGVQGTLMSRDGQTPHLLSTLGKSKRKKDLRISCMSKPPAPNPTTPRNLDSRTFITIGDT
Sbjct: 1 MGVQGTLMSRDGQTPHLLSTLGKSKRKKDLRISCMSKPPAPNPTTPRNLDSRTFITIGDT 60
Query: 61 NFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINM 120
NFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNS EQKRLLMDLDINM
Sbjct: 61 NFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINM 120
Query: 121 RTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVR 180
RTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVR
Sbjct: 121 RTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVR 180
Query: 181 ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPYMAPER 240
ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPYMAPER
Sbjct: 181 ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPYMAPER 240
Query: 241 INPELNQKGYNVKSDVWSLGITMGRALLLRAEPKEDHAAHLAAQAPAAPKLWSSPSSPRE 300
INPELNQKGYNVKSDVWSLGITMGRALLLRAEPKEDHAAHLAAQAPAAPKLWSSPSSPRE
Sbjct: 241 INPELNQKGYNVKSDVWSLGITMGRALLLRAEPKEDHAAHLAAQAPAAPKLWSSPSSPRE 300
Query: 301 WAGARRIECVPQAAVLGEAVGCSIPVLGQPYWALELGRQQQLQALVVDWGVAL 353
WAGARRIECVPQAAVLGEAVGCSIPVLGQPYWALELGRQQQLQALVVDWGVAL
Sbjct: 301 WAGARRIECVPQAAVLGEAVGCSIPVLGQPYWALELGRQQQLQALVVDWGVAL 353
>gi|21618349 mitogen-activated protein kinase kinase 3 isoform B
[Homo sapiens]
Length = 347
Score = 472 bits (1214), Expect = e-133
Identities = 236/249 (94%), Positives = 237/249 (95%)
Query: 22 GKSKRKKDLRISCMSKPPAPNPTTPRNLDSRTFITIGDTNFEVEADDLVTIPELGRGAYG 81
GKSKRKKDLRISCMSKPPAPNPT PRNLDSRTFITIGD NFEVEADDLVTI ELGRGAYG
Sbjct: 17 GKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYG 76
Query: 82 VVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDV 141
VVEKVRH QSGTIMAVK I ATVNS EQKRLLMDLDINMRTVDCFYTVTFYGALFREGDV
Sbjct: 77 VVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDV 136
Query: 142 WICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNV 201
WICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNV
Sbjct: 137 WICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNV 196
Query: 202 LINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGI 261
LINKEGHVKMCDFGISGYLVDSVAK MDAGCKPYMAPERINPELNQKGYNVKSDVWSLGI
Sbjct: 197 LINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGI 256
Query: 262 TMGRALLLR 270
TM +LR
Sbjct: 257 TMIEMAILR 265
>gi|21618347 mitogen-activated protein kinase kinase 3 isoform A
[Homo sapiens]
Length = 318
Score = 446 bits (1147), Expect = e-125
Identities = 223/236 (94%), Positives = 224/236 (94%)
Query: 35 MSKPPAPNPTTPRNLDSRTFITIGDTNFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTI 94
MSKPPAPNPT PRNLDSRTFITIGD NFEVEADDLVTI ELGRGAYGVVEKVRH QSGTI
Sbjct: 1 MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTI 60
Query: 95 MAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 154
MAVK I ATVNS EQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK
Sbjct: 61 MAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDK 120
Query: 155 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 214
FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF
Sbjct: 121 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 180
Query: 215 GISGYLVDSVAKMMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMGRALLLR 270
GISGYLVDSVAK MDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITM +LR
Sbjct: 181 GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILR 236
>gi|14589900 mitogen-activated protein kinase kinase 6 [Homo
sapiens]
Length = 334
Score = 374 bits (961), Expect = e-104
Identities = 191/247 (77%), Positives = 212/247 (85%), Gaps = 1/247 (0%)
Query: 25 KRKKDLRISCMS-KPPAPNPTTPRNLDSRTFITIGDTNFEVEADDLVTIPELGRGAYGVV 83
KR L+I + + P + T PR+LDS+ I+IG+ NFEV+ADDL I ELGRGAYGVV
Sbjct: 8 KRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVV 67
Query: 84 EKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWI 143
EK+RH SG IMAVK I ATVNS EQKRLLMDLDI+MRTVDC +TVTFYGALFREGDVWI
Sbjct: 68 EKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWI 127
Query: 144 CMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLI 203
CMELMDTSLDKFY++V+DK TIPEDILG+IAVSIV+ALEHLHSKLSVIHRDVKPSNVLI
Sbjct: 128 CMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLI 187
Query: 204 NKEGHVKMCDFGISGYLVDSVAKMMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITM 263
N G VKMCDFGISGYLVDSVAK +DAGCKPYMAPERINPELNQKGY+VKSD+WSLGITM
Sbjct: 188 NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITM 247
Query: 264 GRALLLR 270
+LR
Sbjct: 248 IELAILR 254
>gi|239751247 PREDICTED: similar to mitogen-activated protein kinase
kinase 3 [Homo sapiens]
Length = 198
Score = 307 bits (787), Expect = 8e-84
Identities = 149/150 (99%), Positives = 149/150 (99%)
Query: 114 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 173
MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE
Sbjct: 1 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 60
Query: 174 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCK 233
IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAK MDAGCK
Sbjct: 61 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 120
Query: 234 PYMAPERINPELNQKGYNVKSDVWSLGITM 263
PYMAPERINPELNQKGYNVKSDVWSLGITM
Sbjct: 121 PYMAPERINPELNQKGYNVKSDVWSLGITM 150
>gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens]
Length = 399
Score = 261 bits (668), Expect = 5e-70
Identities = 133/237 (56%), Positives = 174/237 (73%), Gaps = 16/237 (6%)
Query: 41 PNPTTPRN----------LDSRTFITIG-DTNFEVEADDLVTIPELGRGAYGVVEKVRHT 89
PNPT +N ++S + I + +++ A+DL + E+GRGAYG V K+ H
Sbjct: 63 PNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHK 122
Query: 90 QSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMD 149
SG IMAVK I +TV+ EQK+LLMDLD+ MR+ DC Y V FYGALFREGD WICMELM
Sbjct: 123 PSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMS 182
Query: 150 TSLDKFYR---KVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKE 206
TS DKFY+ VLD IPE+ILG+I ++ V+AL HL L +IHRD+KPSN+L+++
Sbjct: 183 TSFDKFYKYVYSVLDD--VIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS 240
Query: 207 GHVKMCDFGISGYLVDSVAKMMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITM 263
G++K+CDFGISG LVDS+AK DAGC+PYMAPERI+P +++GY+V+SDVWSLGIT+
Sbjct: 241 GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITL 297
>gi|21735544 mitogen-activated protein kinase kinase 7 [Homo
sapiens]
Length = 419
Score = 192 bits (487), Expect = 5e-49
Identities = 98/211 (46%), Positives = 143/211 (67%), Gaps = 4/211 (1%)
Query: 54 FITIGDTNFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLL 113
++TIG ++ E +DL + E+G G G V K+R ++G ++AVK + + N E KR+L
Sbjct: 105 YLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL 164
Query: 114 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 173
MDLD+ +++ DC Y V +G DV+I MELM T +K +++ IPE ILG+
Sbjct: 165 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGP---IPERILGK 221
Query: 174 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCK 233
+ V+IV+AL +L K VIHRDVKPSN+L+++ G +K+CDFGISG LVDS AK AGC
Sbjct: 222 MTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCA 281
Query: 234 PYMAPERIN-PELNQKGYNVKSDVWSLGITM 263
YMAPERI+ P+ + Y++++DVWSLGI++
Sbjct: 282 AYMAPERIDPPDPTKPDYDIRADVWSLGISL 312
>gi|13489054 mitogen-activated protein kinase kinase 2 [Homo
sapiens]
Length = 400
Score = 164 bits (416), Expect = 9e-41
Identities = 88/202 (43%), Positives = 132/202 (65%), Gaps = 11/202 (5%)
Query: 63 EVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRT 122
E++ DD I ELG G GVV KV+H SG IMA KLI + + +++ +L + +
Sbjct: 66 ELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQV-LHE 124
Query: 123 VDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRA 181
+ Y V FYGA + +G++ ICME MD SLD+ VL + IPE+ILG+++++++R
Sbjct: 125 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKEAKRIPEEILGKVSIAVLRG 180
Query: 182 LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPYMAPERI 241
L +L K ++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A G + YMAPER
Sbjct: 181 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMAPER- 238
Query: 242 NPELNQKGYNVKSDVWSLGITM 263
L Y+V+SD+WS+G+++
Sbjct: 239 ---LQGTHYSVQSDIWSMGLSL 257
>gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens]
Length = 393
Score = 161 bits (408), Expect = 7e-40
Identities = 88/211 (41%), Positives = 133/211 (63%), Gaps = 11/211 (5%)
Query: 54 FITIGDTNFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLL 113
F+T E++ DD I ELG G GVV KV H SG +MA KLI + + +++
Sbjct: 53 FLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII 112
Query: 114 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILG 172
+L + + + Y V FYGA + +G++ ICME MD SLD+ VL K IPE ILG
Sbjct: 113 RELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKKAGRIPEQILG 167
Query: 173 EIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGC 232
++++++++ L +L K ++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A G
Sbjct: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGT 226
Query: 233 KPYMAPERINPELNQKGYNVKSDVWSLGITM 263
+ YM+PER L Y+V+SD+WS+G+++
Sbjct: 227 RSYMSPER----LQGTHYSVQSDIWSMGLSL 253
>gi|21729895 mitogen-activated protein kinase kinase 5 isoform A
[Homo sapiens]
Length = 448
Score = 150 bits (379), Expect = 2e-36
Identities = 89/202 (44%), Positives = 120/202 (59%), Gaps = 14/202 (6%)
Query: 61 NFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINM 120
N ++ D+ LG G G V K H SG I+AVK+I + QK+++ +L+I +
Sbjct: 158 NGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-L 216
Query: 121 RTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVR 180
D Y + FYGA F E + IC E MD YRK+ PE +LG IAV++V+
Sbjct: 217 YKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM-------PEHVLGRIAVAVVK 269
Query: 181 ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPYMAPER 240
L +L S L ++HRDVKPSN+L+N G VK+CDFG+S LV+S+AK G YMAPER
Sbjct: 270 GLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPER 327
Query: 241 INPELNQKGYNVKSDVWSLGIT 262
I+ E Y + SDVWSLGI+
Sbjct: 328 ISGE----QYGIHSDVWSLGIS 345
>gi|4506101 mitogen-activated protein kinase kinase 5 isoform B
[Homo sapiens]
Length = 438
Score = 150 bits (379), Expect = 2e-36
Identities = 89/202 (44%), Positives = 120/202 (59%), Gaps = 14/202 (6%)
Query: 61 NFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINM 120
N ++ D+ LG G G V K H SG I+AVK+I + QK+++ +L+I +
Sbjct: 158 NGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-L 216
Query: 121 RTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVR 180
D Y + FYGA F E + IC E MD YRK+ PE +LG IAV++V+
Sbjct: 217 YKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM-------PEHVLGRIAVAVVK 269
Query: 181 ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPYMAPER 240
L +L S L ++HRDVKPSN+L+N G VK+CDFG+S LV+S+AK G YMAPER
Sbjct: 270 GLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPER 327
Query: 241 INPELNQKGYNVKSDVWSLGIT 262
I+ E Y + SDVWSLGI+
Sbjct: 328 ISGE----QYGIHSDVWSLGIS 345
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 125 bits (313), Expect = 7e-29
Identities = 84/230 (36%), Positives = 127/230 (55%), Gaps = 22/230 (9%)
Query: 35 MSKPPAPNPTTPRNLDSRTFITIGDTNFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTI 94
M +PPAP + L + + F+V + +LG G+YG V K H +SG +
Sbjct: 1 MEQPPAPKSKL-KKLSEDSLTKQPEEVFDV-------LEKLGEGSYGSVFKAIHKESGQV 52
Query: 95 MAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLD 153
+A+K + V S Q+ ++ ++ I M+ D Y V +YG+ F+ D+WI ME S+
Sbjct: 53 VAIKQV--PVESDLQE-IIKEISI-MQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVS 108
Query: 154 KFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCD 213
R +N T+ ED + I S ++ LE+LH + IHRD+K N+L+N EGH K+ D
Sbjct: 109 DIIRL---RNKTLIEDEIATILKSTLKGLEYLHF-MRKIHRDIKAGNILLNTEGHAKLAD 164
Query: 214 FGISGYLVDSVAKMMDA-GCKPYMAPERINPELNQKGYNVKSDVWSLGIT 262
FG++G L D++AK G +MAPE I + GYN +D+WSLGIT
Sbjct: 165 FGVAGQLTDTMAKRNTVIGTPFWMAPEVI----QEIGYNCVADIWSLGIT 210
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 121 bits (304), Expect = 8e-28
Identities = 79/219 (36%), Positives = 124/219 (56%), Gaps = 15/219 (6%)
Query: 47 RNLDSRTFITIGDTNFEVEADDLVTIPE-LGRGAYGVVEKVRHTQSGTIMAVKLIWATVN 105
RN R + + + + +++ + E LG G+YG V K H ++G I+A+K + V
Sbjct: 7 RNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV--PVE 64
Query: 106 SXEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNM 164
S Q+ ++ ++ I M+ D + V +YG+ F+ D+WI ME S+ R +N
Sbjct: 65 SDLQE-IIKEISI-MQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRL---RNK 119
Query: 165 TIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSV 224
T+ ED + I S ++ LE+LH + IHRD+K N+L+N EGH K+ DFG++G L D++
Sbjct: 120 TLTEDEIATILQSTLKGLEYLHF-MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTM 178
Query: 225 AKMMDA-GCKPYMAPERINPELNQKGYNVKSDVWSLGIT 262
AK G +MAPE I + GYN +D+WSLGIT
Sbjct: 179 AKRNTVIGTPFWMAPEVI----QEIGYNCVADIWSLGIT 213
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 104 bits (260), Expect = 1e-22
Identities = 69/220 (31%), Positives = 121/220 (55%), Gaps = 18/220 (8%)
Query: 58 GDTNFEVEADDLVT-IPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDL 116
G TN + + ++L T + ++G+G++G V K ++ ++A+K+I E + + ++
Sbjct: 24 GSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEI 83
Query: 117 DINMRTVDCFYTVTFYGALFREGDVWICMELMD--TSLDKFYRKVLDKNMTIPEDILGEI 174
+ + D Y +YG+ ++ +WI ME + ++LD LD+ + I
Sbjct: 84 TV-LSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQ------IATI 136
Query: 175 AVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDS-VAKMMDAGCK 233
I++ L++LHS+ IHRD+K +NVL+++ G VK+ DFG++G L D+ + + G
Sbjct: 137 LREILKGLDYLHSEKK-IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTP 195
Query: 234 PYMAPERINPELNQKGYNVKSDVWSLGITMGRALLLRAEP 273
+MAPE I Q Y+ K+D+WSLGIT L R EP
Sbjct: 196 FWMAPEVI----KQSAYDSKADIWSLGIT--AIELARGEP 229
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 104 bits (259), Expect = 1e-22
Identities = 66/194 (34%), Positives = 109/194 (56%), Gaps = 7/194 (3%)
Query: 72 IPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTF 131
+ ELG GA+G V K ++ ++G + A K+I T + E + +++++I + T D Y V
Sbjct: 39 VGELGDGAFGKVYKAKNKETGALAAAKVI-ETKSEEELEDYIVEIEI-LATCDHPYIVKL 96
Query: 132 YGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSV 191
GA + +G +WI +E LD+ +T P+ + + ++ AL LHSK +
Sbjct: 97 LGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQ--IQVVCRQMLEALNFLHSK-RI 153
Query: 192 IHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPY-MAPERINPE-LNQKG 249
IHRD+K NVL+ EG +++ DFG+S + ++ K PY MAPE + E +
Sbjct: 154 IHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 213
Query: 250 YNVKSDVWSLGITM 263
Y+ K+D+WSLGIT+
Sbjct: 214 YDYKADIWSLGITL 227
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 101 bits (251), Expect = 1e-21
Identities = 68/220 (30%), Positives = 120/220 (54%), Gaps = 18/220 (8%)
Query: 58 GDTNFEVEADDLVT-IPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDL 116
G N + + ++L T + ++G+G++G V K ++ ++A+K+I E + + ++
Sbjct: 12 GMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEI 71
Query: 117 DINMRTVDCFYTVTFYGALFREGDVWICMELMD--TSLDKFYRKVLDKNMTIPEDILGEI 174
+ + D Y +YG+ ++ +WI ME + ++LD LD+ + I
Sbjct: 72 TV-LSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQ------IATI 124
Query: 175 AVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDS-VAKMMDAGCK 233
I++ L++LHS+ IHRD+K +NVL+++ G VK+ DFG++G L D+ + + G
Sbjct: 125 LREILKGLDYLHSEKK-IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTP 183
Query: 234 PYMAPERINPELNQKGYNVKSDVWSLGITMGRALLLRAEP 273
+MAPE I Q Y+ K+D+WSLGIT L R EP
Sbjct: 184 FWMAPEVI----KQSAYDSKADIWSLGIT--AIELARGEP 217
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 98.6 bits (244), Expect = 7e-21
Identities = 77/250 (30%), Positives = 128/250 (51%), Gaps = 21/250 (8%)
Query: 26 RKKDLRISCMSKP-PAPNPTTPRNLDSRTFITIGDTNF------EVEADDLVTIPELGRG 78
RK+ RIS S P P P R+ D I T+ + + + LG+G
Sbjct: 21 RKQRPRISQTSLPVPGPGSGPQRDSDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQG 80
Query: 79 AYG---VVEKVRHTQSGTIMAVKLIW-ATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGA 134
++G +V KV SG + A+K++ AT+ ++ R M+ DI + V+ + V + A
Sbjct: 81 SFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDI-LADVNHPFVVKLHYA 139
Query: 135 LFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHR 194
EG +++ ++ + D F R L K + E+ + + L+HLHS L +I+R
Sbjct: 140 FQTEGKLYLILDFLRGG-DLFTR--LSKEVMFTEEDVKFYLAELALGLDHLHS-LGIIYR 195
Query: 195 DVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMD-AGCKPYMAPERINPELNQKGYNVK 253
D+KP N+L+++EGH+K+ DFG+S +D K G YMAPE + N++G++
Sbjct: 196 DLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVV----NRQGHSHS 251
Query: 254 SDVWSLGITM 263
+D WS G+ M
Sbjct: 252 ADWWSYGVLM 261
Score = 58.9 bits (141), Expect = 7e-09
Identities = 56/207 (27%), Positives = 99/207 (47%), Gaps = 22/207 (10%)
Query: 64 VEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTV 123
V +D V +G G+Y ++ H + AVK+I + + +++I +R
Sbjct: 422 VFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE-----EIEILLRYG 476
Query: 124 DCFYTVTFYGALFREGDVWICMELMDTS--LDKFYRKVLDKNMTIPEDILGEIAVSIVRA 181
+T V++ ELM LDK R+ E + +I +
Sbjct: 477 QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKF-----FSEREASFVLHTIGKT 531
Query: 182 LEHLHSKLSVIHRDVKPSNVL-INKEGH---VKMCDFGISGYL-VDSVAKMMDAGCKPYM 236
+E+LHS+ V+HRD+KPSN+L +++ G+ +++CDFG + L ++ M ++
Sbjct: 532 VEYLHSQ-GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFV 590
Query: 237 APERINPELNQKGYNVKSDVWSLGITM 263
APE L ++GY+ D+WSLGI +
Sbjct: 591 APE----VLKRQGYDEGCDIWSLGILL 613
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 97.8 bits (242), Expect = 1e-20
Identities = 72/230 (31%), Positives = 113/230 (49%), Gaps = 19/230 (8%)
Query: 42 NPTTPRNLDSRTFITIGDTNFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIW 101
+P R+LD + D E ++V G G YG V K RH ++G + A+K++
Sbjct: 3 DPAPARSLDDIDLSALRDPAGIFELVEVV-----GNGTYGQVYKGRHVKTGQLAAIKVM- 56
Query: 102 ATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGALFREG------DVWICMELMDT-SLDK 154
V E++ + ++++ + T+YGA ++ +W+ ME S+
Sbjct: 57 -DVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTD 115
Query: 155 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 214
+ K + ED + I I+R L HLH+ VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LVKNT--KGNALKEDCIAYICREILRGLAHLHAH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 215 GISGYLVDSVAKMMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGIT 262
G+S L +V + PY MAPE I + N Y+ +SD+WSLGIT
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGIT 222
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 97.8 bits (242), Expect = 1e-20
Identities = 72/230 (31%), Positives = 113/230 (49%), Gaps = 19/230 (8%)
Query: 42 NPTTPRNLDSRTFITIGDTNFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIW 101
+P R+LD + D E ++V G G YG V K RH ++G + A+K++
Sbjct: 3 DPAPARSLDDIDLSALRDPAGIFELVEVV-----GNGTYGQVYKGRHVKTGQLAAIKVM- 56
Query: 102 ATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGALFREG------DVWICMELMDT-SLDK 154
V E++ + ++++ + T+YGA ++ +W+ ME S+
Sbjct: 57 -DVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTD 115
Query: 155 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 214
+ K + ED + I I+R L HLH+ VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LVKNT--KGNALKEDCIAYICREILRGLAHLHAH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 215 GISGYLVDSVAKMMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGIT 262
G+S L +V + PY MAPE I + N Y+ +SD+WSLGIT
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGIT 222
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 97.8 bits (242), Expect = 1e-20
Identities = 72/230 (31%), Positives = 113/230 (49%), Gaps = 19/230 (8%)
Query: 42 NPTTPRNLDSRTFITIGDTNFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIW 101
+P R+LD + D E ++V G G YG V K RH ++G + A+K++
Sbjct: 3 DPAPARSLDDIDLSALRDPAGIFELVEVV-----GNGTYGQVYKGRHVKTGQLAAIKVM- 56
Query: 102 ATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGALFREG------DVWICMELMDT-SLDK 154
V E++ + ++++ + T+YGA ++ +W+ ME S+
Sbjct: 57 -DVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTD 115
Query: 155 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 214
+ K + ED + I I+R L HLH+ VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LVKNT--KGNALKEDCIAYICREILRGLAHLHAH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 215 GISGYLVDSVAKMMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGIT 262
G+S L +V + PY MAPE I + N Y+ +SD+WSLGIT
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGIT 222
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 97.8 bits (242), Expect = 1e-20
Identities = 72/230 (31%), Positives = 113/230 (49%), Gaps = 19/230 (8%)
Query: 42 NPTTPRNLDSRTFITIGDTNFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIW 101
+P R+LD + D E ++V G G YG V K RH ++G + A+K++
Sbjct: 3 DPAPARSLDDIDLSALRDPAGIFELVEVV-----GNGTYGQVYKGRHVKTGQLAAIKVM- 56
Query: 102 ATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGALFREG------DVWICMELMDT-SLDK 154
V E++ + ++++ + T+YGA ++ +W+ ME S+
Sbjct: 57 -DVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTD 115
Query: 155 FYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF 214
+ K + ED + I I+R L HLH+ VIHRD+K NVL+ + VK+ DF
Sbjct: 116 LVKNT--KGNALKEDCIAYICREILRGLAHLHAH-KVIHRDIKGQNVLLTENAEVKLVDF 172
Query: 215 GISGYLVDSVAKMMDAGCKPY-MAPERINPELNQKG-YNVKSDVWSLGIT 262
G+S L +V + PY MAPE I + N Y+ +SD+WSLGIT
Sbjct: 173 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGIT 222
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 97.1 bits (240), Expect = 2e-20
Identities = 63/203 (31%), Positives = 113/203 (55%), Gaps = 16/203 (7%)
Query: 64 VEADDLVT-IPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRT 122
V+ ++L T + +G+G++G V K + ++A+K+I E + + ++ + +
Sbjct: 14 VDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITV-LSQ 72
Query: 123 VDCFYTVTFYGALFREGDVWICMELMD--TSLDKFYRKVLDKNMTIPEDILGEIAVSIVR 180
D Y ++G+ + +WI ME + ++LD L K + E + I I++
Sbjct: 73 CDSPYITRYFGSYLKSTKLWIIMEYLGGGSALD------LLKPGPLEETYIATILREILK 126
Query: 181 ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDS-VAKMMDAGCKPYMAPE 239
L++LHS+ IHRD+K +NVL++++G VK+ DFG++G L D+ + + G +MAPE
Sbjct: 127 GLDYLHSERK-IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 185
Query: 240 RINPELNQKGYNVKSDVWSLGIT 262
I Q Y+ K+D+WSLGIT
Sbjct: 186 VI----KQSAYDFKADIWSLGIT 204
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 96.7 bits (239), Expect = 3e-20
Identities = 66/197 (33%), Positives = 102/197 (51%), Gaps = 14/197 (7%)
Query: 75 LGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGA 134
+G G YG V K RH ++G + A+K++ V E++ + ++++ + T+YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVM--DVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 135 LFREG------DVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHS 187
++ +W+ ME S+ + K T+ E+ + I I+R L HLH
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT--KGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 188 KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPY-MAPERINPELN 246
VIHRD+K NVL+ + VK+ DFG+S L +V + PY MAPE I + N
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 247 QKG-YNVKSDVWSLGIT 262
Y+ KSD+WSLGIT
Sbjct: 206 PDATYDFKSDLWSLGIT 222
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 96.7 bits (239), Expect = 3e-20
Identities = 66/197 (33%), Positives = 102/197 (51%), Gaps = 14/197 (7%)
Query: 75 LGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGA 134
+G G YG V K RH ++G + A+K++ V E++ + ++++ + T+YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVM--DVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 135 LFREG------DVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHS 187
++ +W+ ME S+ + K T+ E+ + I I+R L HLH
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT--KGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 188 KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPY-MAPERINPELN 246
VIHRD+K NVL+ + VK+ DFG+S L +V + PY MAPE I + N
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 247 QKG-YNVKSDVWSLGIT 262
Y+ KSD+WSLGIT
Sbjct: 206 PDATYDFKSDLWSLGIT 222
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 96.7 bits (239), Expect = 3e-20
Identities = 66/197 (33%), Positives = 102/197 (51%), Gaps = 14/197 (7%)
Query: 75 LGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGA 134
+G G YG V K RH ++G + A+K++ V E++ + ++++ + T+YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVM--DVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 135 LFREG------DVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHS 187
++ +W+ ME S+ + K T+ E+ + I I+R L HLH
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT--KGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 188 KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPY-MAPERINPELN 246
VIHRD+K NVL+ + VK+ DFG+S L +V + PY MAPE I + N
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 247 QKG-YNVKSDVWSLGIT 262
Y+ KSD+WSLGIT
Sbjct: 206 PDATYDFKSDLWSLGIT 222
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 96.7 bits (239), Expect = 3e-20
Identities = 66/197 (33%), Positives = 102/197 (51%), Gaps = 14/197 (7%)
Query: 75 LGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGA 134
+G G YG V K RH ++G + A+K++ V E++ + ++++ + T+YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVM--DVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 135 LFREG------DVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHS 187
++ +W+ ME S+ + K T+ E+ + I I+R L HLH
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT--KGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 188 KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPY-MAPERINPELN 246
VIHRD+K NVL+ + VK+ DFG+S L +V + PY MAPE I + N
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 247 QKG-YNVKSDVWSLGIT 262
Y+ KSD+WSLGIT
Sbjct: 206 PDATYDFKSDLWSLGIT 222
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 96.7 bits (239), Expect = 3e-20
Identities = 66/197 (33%), Positives = 102/197 (51%), Gaps = 14/197 (7%)
Query: 75 LGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGA 134
+G G YG V K RH ++G + A+K++ V E++ + ++++ + T+YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVM--DVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 135 LFREG------DVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHS 187
++ +W+ ME S+ + K T+ E+ + I I+R L HLH
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT--KGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 188 KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPY-MAPERINPELN 246
VIHRD+K NVL+ + VK+ DFG+S L +V + PY MAPE I + N
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 247 QKG-YNVKSDVWSLGIT 262
Y+ KSD+WSLGIT
Sbjct: 206 PDATYDFKSDLWSLGIT 222
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 96.7 bits (239), Expect = 3e-20
Identities = 66/197 (33%), Positives = 102/197 (51%), Gaps = 14/197 (7%)
Query: 75 LGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGA 134
+G G YG V K RH ++G + A+K++ V E++ + ++++ + T+YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVM--DVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 135 LFREG------DVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHS 187
++ +W+ ME S+ + K T+ E+ + I I+R L HLH
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT--KGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 188 KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPY-MAPERINPELN 246
VIHRD+K NVL+ + VK+ DFG+S L +V + PY MAPE I + N
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 247 QKG-YNVKSDVWSLGIT 262
Y+ KSD+WSLGIT
Sbjct: 206 PDATYDFKSDLWSLGIT 222
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 96.7 bits (239), Expect = 3e-20
Identities = 66/197 (33%), Positives = 102/197 (51%), Gaps = 14/197 (7%)
Query: 75 LGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGA 134
+G G YG V K RH ++G + A+K++ V E++ + ++++ + T+YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVM--DVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 135 LFREG------DVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHS 187
++ +W+ ME S+ + K T+ E+ + I I+R L HLH
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT--KGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 188 KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPY-MAPERINPELN 246
VIHRD+K NVL+ + VK+ DFG+S L +V + PY MAPE I + N
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 247 QKG-YNVKSDVWSLGIT 262
Y+ KSD+WSLGIT
Sbjct: 206 PDATYDFKSDLWSLGIT 222
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 96.7 bits (239), Expect = 3e-20
Identities = 66/197 (33%), Positives = 102/197 (51%), Gaps = 14/197 (7%)
Query: 75 LGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGA 134
+G G YG V K RH ++G + A+K++ V E++ + ++++ + T+YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVM--DVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 135 LFREG------DVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHS 187
++ +W+ ME S+ + K T+ E+ + I I+R L HLH
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT--KGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 188 KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPY-MAPERINPELN 246
VIHRD+K NVL+ + VK+ DFG+S L +V + PY MAPE I + N
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 247 QKG-YNVKSDVWSLGIT 262
Y+ KSD+WSLGIT
Sbjct: 206 PDATYDFKSDLWSLGIT 222
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,951,460
Number of Sequences: 37866
Number of extensions: 643337
Number of successful extensions: 3591
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 518
Number of HSP's successfully gapped in prelim test: 257
Number of HSP's that attempted gapping in prelim test: 2168
Number of HSP's gapped (non-prelim): 899
length of query: 353
length of database: 18,247,518
effective HSP length: 103
effective length of query: 250
effective length of database: 14,347,320
effective search space: 3586830000
effective search space used: 3586830000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.