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Search of human proteins with 119393878
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119393878 NLR family, apoptosis inhibitory protein isoform 1
[Homo sapiens]
(1403 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119393878 NLR family, apoptosis inhibitory protein isoform 1 ... 2819 0.0
gi|119393876 NLR family, apoptosis inhibitory protein isoform 2 ... 2356 0.0
gi|40788015 caspase recruitment domain protein 12 [Homo sapiens] 209 2e-53
gi|4502141 baculoviral IAP repeat-containing protein 2 [Homo sap... 159 1e-38
gi|33946285 baculoviral IAP repeat-containing protein 3 [Homo sa... 152 3e-36
gi|4502139 baculoviral IAP repeat-containing protein 3 [Homo sap... 152 3e-36
gi|32528299 baculoviral IAP repeat-containing protein 4 [Homo sa... 140 9e-33
gi|11545910 livin inhibitor of apoptosis isoform beta [Homo sapi... 94 7e-19
gi|21536421 livin inhibitor of apoptosis isoform alpha [Homo sap... 94 7e-19
gi|44680139 baculoviral IAP repeat-containing 8 [Homo sapiens] 82 5e-15
gi|59859878 baculoviral IAP repeat-containing protein 5 isoform ... 62 4e-09
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 61 7e-09
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 58 7e-08
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 58 7e-08
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 58 7e-08
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 58 7e-08
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 58 7e-08
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 55 5e-07
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 54 1e-06
gi|153792694 baculoviral IAP repeat-containing 6 [Homo sapiens] 53 2e-06
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 52 3e-06
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 52 3e-06
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 52 3e-06
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 52 3e-06
gi|113205085 leucine rich repeat containing 31 [Homo sapiens] 50 2e-05
gi|59859882 baculoviral IAP repeat-containing protein 5 isoform ... 49 3e-05
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 46 2e-04
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 46 2e-04
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 46 2e-04
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 46 2e-04
>gi|119393878 NLR family, apoptosis inhibitory protein isoform 1 [Homo
sapiens]
Length = 1403
Score = 2819 bits (7307), Expect = 0.0
Identities = 1403/1403 (100%), Positives = 1403/1403 (100%)
Query: 1 MATQQKASDERISQFDHNLLPELSALLGLDAVQLAKELEEEEQKERAKMQKGYNSQMRSE 60
MATQQKASDERISQFDHNLLPELSALLGLDAVQLAKELEEEEQKERAKMQKGYNSQMRSE
Sbjct: 1 MATQQKASDERISQFDHNLLPELSALLGLDAVQLAKELEEEEQKERAKMQKGYNSQMRSE 60
Query: 61 AKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKRF 120
AKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKRF
Sbjct: 61 AKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKRF 120
Query: 121 HPDCGFLLNKDVGNIAKYDIRVKNLKSRLRGGKMRYQEEEARLASFRNWPFYVQGISPCV 180
HPDCGFLLNKDVGNIAKYDIRVKNLKSRLRGGKMRYQEEEARLASFRNWPFYVQGISPCV
Sbjct: 121 HPDCGFLLNKDVGNIAKYDIRVKNLKSRLRGGKMRYQEEEARLASFRNWPFYVQGISPCV 180
Query: 181 LSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYI 240
LSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYI
Sbjct: 181 LSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYI 240
Query: 241 QSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRLDSFKDWPRESAVGVAALA 300
QSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRLDSFKDWPRESAVGVAALA
Sbjct: 241 QSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRLDSFKDWPRESAVGVAALA 300
Query: 301 KAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQNMKSSAEVTPDLQS 360
KAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQNMKSSAEVTPDLQS
Sbjct: 301 KAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQNMKSSAEVTPDLQS 360
Query: 361 RGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKNLNEQLRAAYTSASFRHMS 420
RGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKNLNEQLRAAYTSASFRHMS
Sbjct: 361 RGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKNLNEQLRAAYTSASFRHMS 420
Query: 421 LLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNLNSVMCVEGEAGSGKTVLL 480
LLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNLNSVMCVEGEAGSGKTVLL
Sbjct: 421 LLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNLNSVMCVEGEAGSGKTVLL 480
Query: 481 KKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEGSVTEMCVRNIIQ 540
KKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEGSVTEMCVRNIIQ
Sbjct: 481 KKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEGSVTEMCVRNIIQ 540
Query: 541 QLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVRTNRARDIRRYLETILEIK 600
QLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVRTNRARDIRRYLETILEIK
Sbjct: 541 QLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVRTNRARDIRRYLETILEIK 600
Query: 601 AFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPS 660
AFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPS
Sbjct: 601 AFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPS 660
Query: 661 FDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDED 720
FDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDED
Sbjct: 661 FDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDED 720
Query: 721 EDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINS 780
EDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINS
Sbjct: 721 EDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINS 780
Query: 781 PMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQ 840
PMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQ
Sbjct: 781 PMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQ 840
Query: 841 MQLLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAACSPFVLQFLQGRTLTLGALNL 900
MQLLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAACSPFVLQFLQGRTLTLGALNL
Sbjct: 841 MQLLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAACSPFVLQFLQGRTLTLGALNL 900
Query: 901 QYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEW 960
QYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEW
Sbjct: 901 QYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEW 960
Query: 961 ERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDMLEIL 1020
ERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDMLEIL
Sbjct: 961 ERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDMLEIL 1020
Query: 1021 MTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLE 1080
MTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLE
Sbjct: 1021 MTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLE 1080
Query: 1081 SLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISA 1140
SLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISA
Sbjct: 1081 SLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISA 1140
Query: 1141 EYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKKLTEIKFSDSFFQAVPFVA 1200
EYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKKLTEIKFSDSFFQAVPFVA
Sbjct: 1141 EYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKKLTEIKFSDSFFQAVPFVA 1200
Query: 1201 SLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQ 1260
SLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQ
Sbjct: 1201 SLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQ 1260
Query: 1261 QLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEEGYRNFFQALDNM 1320
QLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEEGYRNFFQALDNM
Sbjct: 1261 QLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEEGYRNFFQALDNM 1320
Query: 1321 PNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMKER 1380
PNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMKER
Sbjct: 1321 PNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMKER 1380
Query: 1381 HPQSKYLTILQKWILPFSPIIQK 1403
HPQSKYLTILQKWILPFSPIIQK
Sbjct: 1381 HPQSKYLTILQKWILPFSPIIQK 1403
>gi|119393876 NLR family, apoptosis inhibitory protein isoform 2 [Homo
sapiens]
Length = 1241
Score = 2356 bits (6106), Expect = 0.0
Identities = 1180/1181 (99%), Positives = 1181/1181 (100%)
Query: 223 KCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRL 282
+CEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRL
Sbjct: 61 RCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRL 120
Query: 283 DSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNC 342
DSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNC
Sbjct: 121 DSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNC 180
Query: 343 PFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKN 402
PFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKN
Sbjct: 181 PFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKN 240
Query: 403 LNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNL 462
LNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNL
Sbjct: 241 LNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNL 300
Query: 463 NSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQ 522
NSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQ
Sbjct: 301 NSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQ 360
Query: 523 LLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVR 582
LLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVR
Sbjct: 361 LLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVR 420
Query: 583 TNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTP 642
TNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTP
Sbjct: 421 TNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTP 480
Query: 643 LFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFS 702
LFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFS
Sbjct: 481 LFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFS 540
Query: 703 CCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDS 762
CCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDS
Sbjct: 541 CCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDS 600
Query: 763 DRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLE 822
DRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLE
Sbjct: 601 DRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLE 660
Query: 823 NISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAACSP 882
NISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAACSP
Sbjct: 661 NISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAACSP 720
Query: 883 FVLQFLQGRTLTLGALNLQYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQ 942
FVLQFLQGRTLTLGALNLQYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQ
Sbjct: 721 FVLQFLQGRTLTLGALNLQYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQ 780
Query: 943 VPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCL 1002
VPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCL
Sbjct: 781 VPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCL 840
Query: 1003 EVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISK 1062
EVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISK
Sbjct: 841 EVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISK 900
Query: 1063 LELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIP 1122
LELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIP
Sbjct: 901 LELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIP 960
Query: 1123 EEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKK 1182
EEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKK
Sbjct: 961 EEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKK 1020
Query: 1183 LTEIKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELIL 1242
LTEIKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELIL
Sbjct: 1021 LTEIKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELIL 1080
Query: 1243 PTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSIN 1302
PTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSIN
Sbjct: 1081 PTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSIN 1140
Query: 1303 HKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNML 1362
HKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNML
Sbjct: 1141 HKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNML 1200
Query: 1363 SWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK 1403
SWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK
Sbjct: 1201 SWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK 1241
Score = 96.3 bits (238), Expect = 2e-19
Identities = 43/84 (51%), Positives = 57/84 (67%), Gaps = 1/84 (1%)
Query: 159 EEARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHA 218
EE RL SF++WP + L++AG +TG +D VQCFSCGGCL W+EGDDP +H
Sbjct: 116 EELRLDSFKDWP-RESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHT 174
Query: 219 KWFPKCEFLRSKKSSEEITQYIQS 242
+ FP C FL++ KSS E+T +QS
Sbjct: 175 RCFPNCPFLQNMKSSAEVTPDLQS 198
Score = 45.1 bits (105), Expect = 5e-04
Identities = 25/70 (35%), Positives = 36/70 (51%)
Query: 60 EAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKR 119
E RL +F + S+ +A AG ++TG+K +QCF C L P++DH R
Sbjct: 116 EELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTR 175
Query: 120 FHPDCGFLLN 129
P+C FL N
Sbjct: 176 CFPNCPFLQN 185
>gi|40788015 caspase recruitment domain protein 12 [Homo sapiens]
Length = 1024
Score = 209 bits (532), Expect = 2e-53
Identities = 236/951 (24%), Positives = 416/951 (43%), Gaps = 112/951 (11%)
Query: 451 EPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTR 510
E L L + L S +EGE+G GK+ LL++IA LW SG C L +F+ VF+L LS R
Sbjct: 150 EQLTLNGLLQALQSPCIIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLS--R 207
Query: 511 PDEGLASIICDQLLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEIC--SIPQVIGKLIQ 568
GL +CDQLL+ G++ + ++ +L+ +VLFLLD Y E + P+ I LI+
Sbjct: 208 AQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFKPQNCPE-IEALIK 266
Query: 569 KNHLSRTCLLIAVRTNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVY 628
+NH + +++ T R IR++ E+ + ++R++ + ++
Sbjct: 267 ENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKELAE--GLLLQ 324
Query: 629 FGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNK------ATA 682
K++ L+ + KTPLFV CA S +F ++ + L +NK A +
Sbjct: 325 IQKSRCLRNLMKTPLFVVITCAIQMGESEFHSHTQTTLFHTFYDLLIQKNKHKHKGVAAS 384
Query: 683 EILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRF 742
+ +++ + CG+LAL+G FS F+F D++ V+ED LT L+ K+TAQR +P Y+F
Sbjct: 385 DFIRS-LDHCGDLALEGVFSHKFDFELQDVSS--VNEDVLLTTGLLCKYTAQRFKPKYKF 441
Query: 743 LSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYV--SSLPS 800
+FQE+ AG RL LL S E G +L+++ S S Y++ L Y SS+ +
Sbjct: 442 FHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYTCGSSVEA 501
Query: 801 TKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVS 860
T+A ++ HL V L +S L Q + L+ + Q ++
Sbjct: 502 TRA---VMKHLA-AVYQHGCLLGLSIAKRPLWRQ-------ESLQSVKNTTEQEILKAIN 550
Query: 861 EHLLVLALKTAYQSNT-VAACSPFVLQFLQGRTLTLGALNL-QYFFDHPESLSLLRSIHF 918
+ V YQ +T +A S F QG++L + + N+ Y FD
Sbjct: 551 INSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFD------------- 597
Query: 919 PIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVKSYM-DM 977
F L C S + I D+ M WE+ ED +M +
Sbjct: 598 -----------FFEHLPNC--ASALDFIKLDFYGG--AMASWEK---AAEDTGGIHMEEA 639
Query: 978 QRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHS 1037
P + + ++++ LEV + D + + + L +FS++ + L +
Sbjct: 640 PETYIPSRAVSLFFNWKQEFR--TLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRC 697
Query: 1038 RGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPN 1097
G S+ L K ++ + L+ ++ + ++ +L++L + Q+Q P
Sbjct: 698 AGVAGSLSLVLSTCK-NIYSLMVEASPLTIEDERHITSVTNLKTLSIH---DLQNQRLPG 753
Query: 1098 --LDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSP 1155
D LK L+ + NI + E D KL + ++N
Sbjct: 754 GLTDSLGNLKNLTKLIMDNIKM----------------------NEEDAIKLAEGLKNLK 791
Query: 1156 NLHVFHLKCNFFSDFGSLMTMLVSCKK-----LTEIKFSDSFF--QAVPFVA-SLPNFIS 1207
+ +FHL SD G M +V L EI+ AV +A +L N +
Sbjct: 792 KMCLFHL--THLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVK 849
Query: 1208 LKILNLEGQQFPDEETSEKFAYILGSLSNLEE---LILPTGDGIYRVAKLIIQQCQQLHC 1264
L IL+L + + +++ +E ++ ++ LE+ L+LP G + +++ +++
Sbjct: 850 LSILDL-SENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQ 908
Query: 1265 LRVLSFFK-TLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEEGYRNFFQALDNMPNL 1323
L L L D + + + + L L+ N +++ +G+ F +N+ L
Sbjct: 909 LVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGN-RVSSDGWLAFMGVFENLKQL 967
Query: 1324 QELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALL 1374
D S T+ V+ LSQ + +L L ++ W D DD++++
Sbjct: 968 VFFDFS---TKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVI 1015
Score = 40.0 bits (92), Expect = 0.016
Identities = 54/248 (21%), Positives = 105/248 (42%), Gaps = 42/248 (16%)
Query: 1171 GSLMTMLVSCKKLTE--IKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKFA 1228
GSL +L +CK + ++ S + + S+ N +L I +L+ Q+ P T
Sbjct: 702 GSLSLVLSTCKNIYSLMVEASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDS--- 758
Query: 1229 YILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVE----IAK 1284
LG+L NL +LI+ D I + I+ + L L+ + F + + E I K
Sbjct: 759 --LGNLKNLTKLIM---DNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVK 813
Query: 1285 VAISGGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQAT--- 1341
++S LE ++L ++ ++ + Q L N+ L LD+S ++ E +A
Sbjct: 814 -SLSSEPCDLEEIQL-VSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHEL 871
Query: 1342 -----------------------TVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMK 1378
++ SL + + +P+L++L + +W L +I +L
Sbjct: 872 IDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFF 931
Query: 1379 ERHPQSKY 1386
++P +
Sbjct: 932 GKNPLKNF 939
>gi|4502141 baculoviral IAP repeat-containing protein 2 [Homo
sapiens]
Length = 618
Score = 159 bits (403), Expect = 1e-38
Identities = 113/367 (30%), Positives = 158/367 (43%), Gaps = 76/367 (20%)
Query: 60 EAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKR 119
E R+ T+ T+ + +A AGFY+TGV ++CFCC L+L L PI+ HK+
Sbjct: 46 ELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQ 105
Query: 120 FHPDCGFLLN---KDVGNIAKYDIRVKNL------------------------------- 145
+P C F+ N +G+ +K ++N
Sbjct: 106 LYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRA 165
Query: 146 -----KSRLRGGKMRYQEEEARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSC 200
SR EEAR ++ WP +SP L+ AGF + G D V CF+C
Sbjct: 166 VEDISSSRTNPYSYAMSTEEARFLTYHMWPLTF--LSPSELARAGFYYIGPGDRVACFAC 223
Query: 201 GGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQ 260
GG L NWE DD EH + FP C FL ++S E ++ S
Sbjct: 224 GGKLSNWEPKDDAMSEHRRHFPNCPFL---ENSLETLRFSIS------------------ 262
Query: 261 RELPMASAYCNDSIFAYEELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGG 320
L M + R+ +F WP V LA AG +Y G D V+CF C G
Sbjct: 263 -NLSMQT----------HAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDG 311
Query: 321 CLEKWQEGDDPLDDHTRCFPNCPFLQNMKSSAEVTPDLQSR-GELCELLETTSESNLEDS 379
L W+ GDDP +H + FP C FL MK E ++Q R L E L +TS++ E++
Sbjct: 312 GLRCWESGDDPWVEHAKWFPRCEFLIRMKGQ-EFVDEIQGRYPHLLEQLLSTSDTTGEEN 370
Query: 380 IAVGPIV 386
A PI+
Sbjct: 371 -ADPPII 376
Score = 118 bits (296), Expect = 3e-26
Identities = 72/207 (34%), Positives = 98/207 (47%), Gaps = 22/207 (10%)
Query: 53 YNSQMRSEAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRL 112
Y+ M +E R T+ + P + P E+A AGFY+ G + CF C L
Sbjct: 177 YSYAMSTEEARFLTYHMW-PLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDD 235
Query: 113 PIEDHKRFHPDCGFLLNKDVGNIAKYDIRVKNLKSRLRGGKMRYQEEEARLASFRNWPFY 172
+ +H+R P+C FL N ++ + NL Q AR+ +F WP
Sbjct: 236 AMSEHRRHFPNCPFLEN----SLETLRFSISNLSM---------QTHAARMRTFMYWPSS 282
Query: 173 VQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKS 232
V + P L+ AGF + G+ D V+CF C G L WE GDDPW EHAKWFP+CEFL K
Sbjct: 283 VP-VQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKG 341
Query: 233 SEEITQYIQSYKGFV-------DITGE 252
E + + Y + D TGE
Sbjct: 342 QEFVDEIQGRYPHLLEQLLSTSDTTGE 368
Score = 114 bits (286), Expect = 5e-25
Identities = 69/217 (31%), Positives = 107/217 (49%), Gaps = 24/217 (11%)
Query: 153 KMRYQE--EEARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEG 210
KM+Y E R++++ +P V +S L+ AGF +TG D V+CF CG L NW+ G
Sbjct: 38 KMKYDFSCELYRMSTYSTFPAGVP-VSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLG 96
Query: 211 DDPWKEHAKWFPKCEFLR----------SKKSSEEITQYIQS----------YKGFVDIT 250
D P ++H + +P C F++ SK +S + S + G
Sbjct: 97 DSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSL 156
Query: 251 GEHFVNSWVQRELPMASAYCNDSIFAYEELRLDSFKDWPRESAVGVAALAKAGLFYTGIK 310
+ +NS ++ + + EE R ++ WP + + + LA+AG +Y G
Sbjct: 157 SPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPL-TFLSPSELARAGFYYIGPG 215
Query: 311 DIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQN 347
D V CF+CGG L W+ DD + +H R FPNCPFL+N
Sbjct: 216 DRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLEN 252
Score = 74.7 bits (182), Expect = 6e-13
Identities = 30/78 (38%), Positives = 50/78 (64%)
Query: 275 FAYEELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDD 334
F+ E R+ ++ +P V +LA+AG +YTG+ D V+CF CG L+ W+ GD P+
Sbjct: 43 FSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQK 102
Query: 335 HTRCFPNCPFLQNMKSSA 352
H + +P+C F+QN+ S++
Sbjct: 103 HKQLYPSCSFIQNLVSAS 120
>gi|33946285 baculoviral IAP repeat-containing protein 3 [Homo
sapiens]
Length = 604
Score = 152 bits (383), Expect = 3e-36
Identities = 110/366 (30%), Positives = 153/366 (41%), Gaps = 78/366 (21%)
Query: 60 EAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKR 119
E R+ T+ T+ + +A AGFY+TGV ++CFCC L+L P E HK+
Sbjct: 29 ELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKK 88
Query: 120 FHPDCGFLLN-KDVGNIAK-----YDIRVKNLKSRLRGGK-------------------- 153
+P C F+ + V N+ + V N L G
Sbjct: 89 LYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNS 148
Query: 154 ---------MR------YQEEEARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCF 198
MR E ARL +F+ WP +SP L++AGF + G D V CF
Sbjct: 149 RANQDFSALMRSSYHCAMNNENARLLTFQTWPLTF--LSPTDLAKAGFYYIGPGDRVACF 206
Query: 199 SCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSW 258
+CGG L NWE D+ EH + FPKC F+ ++ ++ ++Y S
Sbjct: 207 ACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQL--QDTSRYTVS---------------- 248
Query: 259 VQRELPMASAYCNDSIFAYEELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSC 318
L M + R +F +WP V LA AG +Y G D V+CF C
Sbjct: 249 ---NLSMQT----------HAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCC 295
Query: 319 GGCLEKWQEGDDPLDDHTRCFPNCPFLQNMKSSAEVTPDLQSRGELCELLETTSES---- 374
G L W+ GDDP H + FP C +L +K + S L E L +TS+S
Sbjct: 296 DGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDE 355
Query: 375 NLEDSI 380
N E SI
Sbjct: 356 NAESSI 361
Score = 125 bits (315), Expect = 2e-28
Identities = 72/197 (36%), Positives = 100/197 (50%), Gaps = 14/197 (7%)
Query: 47 AKMQKGYNSQMRSEAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFG 106
A M+ Y+ M +E RL TF T+ P + P ++A AGFY+ G + CF C L
Sbjct: 156 ALMRSSYHCAMNNENARLLTFQTW-PLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSN 214
Query: 107 AGLTRLPIEDHKRFHPDCGFLLNKDVGNIAKYDIRVKNLKSRLRGGKMRYQEEEARLASF 166
+ +H R P C F+ N+ + + ++Y + + Q AR +F
Sbjct: 215 WEPKDNAMSEHLRHFPKCPFIENQ-LQDTSRYTV-----------SNLSMQTHAARFKTF 262
Query: 167 RNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEF 226
NWP V ++P L+ AGF + G D V+CF C G L WE GDDPW +HAKWFP+CE+
Sbjct: 263 FNWPSSVL-VNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEY 321
Query: 227 LRSKKSSEEITQYIQSY 243
L K E I Q SY
Sbjct: 322 LIRIKGQEFIRQVQASY 338
Score = 118 bits (295), Expect = 5e-26
Identities = 72/238 (30%), Positives = 112/238 (47%), Gaps = 26/238 (10%)
Query: 134 NIAKYDIRVKNLKSRLRGGKMRYQE--EEARLASFRNWPFYVQGISPCVLSEAGFVFTGK 191
NI + I + NL +++Y E R++++ +P V +S L+ AGF +TG
Sbjct: 2 NIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVP-VSERSLARAGFYYTGV 60
Query: 192 QDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEI--------------- 236
D V+CF CG L NW+ GD P ++H K +P C F++S S +
Sbjct: 61 NDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNS 120
Query: 237 -------TQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRLDSFKDWP 289
T+ ++G + + VNS ++ E RL +F+ WP
Sbjct: 121 THSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWP 180
Query: 290 RESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQN 347
+ + LAKAG +Y G D V CF+CGG L W+ D+ + +H R FP CPF++N
Sbjct: 181 L-TFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIEN 237
>gi|4502139 baculoviral IAP repeat-containing protein 3 [Homo
sapiens]
Length = 604
Score = 152 bits (383), Expect = 3e-36
Identities = 110/366 (30%), Positives = 153/366 (41%), Gaps = 78/366 (21%)
Query: 60 EAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKR 119
E R+ T+ T+ + +A AGFY+TGV ++CFCC L+L P E HK+
Sbjct: 29 ELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKK 88
Query: 120 FHPDCGFLLN-KDVGNIAK-----YDIRVKNLKSRLRGGK-------------------- 153
+P C F+ + V N+ + V N L G
Sbjct: 89 LYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNS 148
Query: 154 ---------MR------YQEEEARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCF 198
MR E ARL +F+ WP +SP L++AGF + G D V CF
Sbjct: 149 RANQDFSALMRSSYHCAMNNENARLLTFQTWPLTF--LSPTDLAKAGFYYIGPGDRVACF 206
Query: 199 SCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSW 258
+CGG L NWE D+ EH + FPKC F+ ++ ++ ++Y S
Sbjct: 207 ACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQL--QDTSRYTVS---------------- 248
Query: 259 VQRELPMASAYCNDSIFAYEELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSC 318
L M + R +F +WP V LA AG +Y G D V+CF C
Sbjct: 249 ---NLSMQT----------HAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCC 295
Query: 319 GGCLEKWQEGDDPLDDHTRCFPNCPFLQNMKSSAEVTPDLQSRGELCELLETTSES---- 374
G L W+ GDDP H + FP C +L +K + S L E L +TS+S
Sbjct: 296 DGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDE 355
Query: 375 NLEDSI 380
N E SI
Sbjct: 356 NAESSI 361
Score = 125 bits (315), Expect = 2e-28
Identities = 72/197 (36%), Positives = 100/197 (50%), Gaps = 14/197 (7%)
Query: 47 AKMQKGYNSQMRSEAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFG 106
A M+ Y+ M +E RL TF T+ P + P ++A AGFY+ G + CF C L
Sbjct: 156 ALMRSSYHCAMNNENARLLTFQTW-PLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSN 214
Query: 107 AGLTRLPIEDHKRFHPDCGFLLNKDVGNIAKYDIRVKNLKSRLRGGKMRYQEEEARLASF 166
+ +H R P C F+ N+ + + ++Y + + Q AR +F
Sbjct: 215 WEPKDNAMSEHLRHFPKCPFIENQ-LQDTSRYTV-----------SNLSMQTHAARFKTF 262
Query: 167 RNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEF 226
NWP V ++P L+ AGF + G D V+CF C G L WE GDDPW +HAKWFP+CE+
Sbjct: 263 FNWPSSVL-VNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEY 321
Query: 227 LRSKKSSEEITQYIQSY 243
L K E I Q SY
Sbjct: 322 LIRIKGQEFIRQVQASY 338
Score = 118 bits (295), Expect = 5e-26
Identities = 72/238 (30%), Positives = 112/238 (47%), Gaps = 26/238 (10%)
Query: 134 NIAKYDIRVKNLKSRLRGGKMRYQE--EEARLASFRNWPFYVQGISPCVLSEAGFVFTGK 191
NI + I + NL +++Y E R++++ +P V +S L+ AGF +TG
Sbjct: 2 NIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVP-VSERSLARAGFYYTGV 60
Query: 192 QDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEI--------------- 236
D V+CF CG L NW+ GD P ++H K +P C F++S S +
Sbjct: 61 NDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNS 120
Query: 237 -------TQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRLDSFKDWP 289
T+ ++G + + VNS ++ E RL +F+ WP
Sbjct: 121 THSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWP 180
Query: 290 RESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQN 347
+ + LAKAG +Y G D V CF+CGG L W+ D+ + +H R FP CPF++N
Sbjct: 181 L-TFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIEN 237
>gi|32528299 baculoviral IAP repeat-containing protein 4 [Homo
sapiens]
Length = 497
Score = 140 bits (353), Expect = 9e-33
Identities = 120/407 (29%), Positives = 179/407 (43%), Gaps = 66/407 (16%)
Query: 60 EAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKR 119
E RLKTF + S +A AGF +TG ++CF C + + H++
Sbjct: 26 EFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK 85
Query: 120 FHPDC----GFLLNKDV-----GNIAKYDIRVKN-LKSR----------------LRGGK 153
P+C GF L I +V+N L SR LR G+
Sbjct: 86 VSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQ 145
Query: 154 M------------RYQEEEARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCG 201
+ EEARL SF+NWP Y ++P L+ AG +TG D VQCF CG
Sbjct: 146 VVDISDTIYPRNPAMYSEEARLKSFQNWPDYAH-LTPRELASAGLYYTGIGDQVQCFCCG 204
Query: 202 GCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQR 261
G L NWE D W EH + FP C F+ + + I+S V + +F NS
Sbjct: 205 GKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLN------IRSESDAVS-SDRNFPNS---T 254
Query: 262 ELPMASAYCNDSIFAYEELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGC 321
LP N S+ YE R+ +F W +V LA+AG + G D V+CF CGG
Sbjct: 255 NLPR-----NPSMADYEA-RIFTFGTWIY--SVNKEQLARAGFYALGEGDKVKCFHCGGG 306
Query: 322 LEKWQEGDDPLDDHTRCFPNCPFLQNMKSSAEVTPDLQSRGELCELLETTSES------N 375
L W+ +DP + H + +P C +L K E ++ L E L T+E
Sbjct: 307 LTDWKPSEDPWEQHAKWYPGCKYLLEQKGQ-EYINNIHLTHSLEECLVRTTEKTPSLTRR 365
Query: 376 LEDSIAVGPIVPEMAQGEAQWFQEAKNLNEQLRAAYTSASFRHMSLL 422
++D+I P+V E + F++ K + E+ + + ++++ + +L
Sbjct: 366 IDDTIFQNPMVQEAIRMGFS-FKDIKKIMEE-KIQISGSNYKSLEVL 410
Score = 124 bits (311), Expect = 6e-28
Identities = 65/188 (34%), Positives = 101/188 (53%), Gaps = 10/188 (5%)
Query: 54 NSQMRSEAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLP 113
N M SE RLK+F + Y+ P+E+A+AG Y+TG+ +QCFCC L
Sbjct: 157 NPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRA 216
Query: 114 IEDHKRFHPDCGFLLNKDVG-----NIAKYDIRVKNLKSRLRGGKMRYQEEEARLASFRN 168
+H+R P+C F+L +++ + D N + R M + EAR+ +F
Sbjct: 217 WSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMA--DYEARIFTFGT 274
Query: 169 WPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLR 228
W + ++ L+ AGF G+ D V+CF CGG L +W+ +DPW++HAKW+P C++L
Sbjct: 275 W---IYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLL 331
Query: 229 SKKSSEEI 236
+K E I
Sbjct: 332 EQKGQEYI 339
Score = 118 bits (295), Expect = 5e-26
Identities = 89/268 (33%), Positives = 125/268 (46%), Gaps = 46/268 (17%)
Query: 156 YQEEEARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWK 215
+ EE RL +F N+P +S L+ AGF++TG+ DTV+CFSC + W+ GD
Sbjct: 23 FVEEFNRLKTFANFPSG-SPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVG 81
Query: 216 EHAKWFPKCEFL----------RSKKSSEEITQY-IQSYKGFVDITGEHFVNSWVQRELP 264
H K P C F+ +S S + QY +++Y G D HF + R
Sbjct: 82 RHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRD----HFA---LDRPSE 134
Query: 265 MASAYC---------NDSIFAY------EELRLDSFKDWPRESAVGVAALAKAGLFYTGI 309
+ Y +D+I+ EE RL SF++WP + + LA AGL+YTGI
Sbjct: 135 THADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGI 194
Query: 310 KDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQNMKSSAEVTPDLQSRGELCELLE 369
D VQCF CGG L+ W+ D +H R FPNC F+ + D S
Sbjct: 195 GDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVS--------- 245
Query: 370 TTSESNLEDSIAVGPIVPEMAQGEAQWF 397
S+ N +S + P P MA EA+ F
Sbjct: 246 --SDRNFPNSTNL-PRNPSMADYEARIF 270
>gi|11545910 livin inhibitor of apoptosis isoform beta [Homo
sapiens]
Length = 280
Score = 94.4 bits (233), Expect = 7e-19
Identities = 54/124 (43%), Positives = 69/124 (55%), Gaps = 11/124 (8%)
Query: 159 EEARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHA 218
EE RLASF +WP + + P +L+ AGF TG QD V+CF C G L +W+ GDDPW EHA
Sbjct: 87 EELRLASFYDWPLTAE-VPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHA 145
Query: 219 KWFPKCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFA-- 276
KWFP C+FL K + ++ S V T + SW E P +A S+ A
Sbjct: 146 KWFPSCQFLLRSKGRD----FVHS----VQETHSQLLGSWDPWEEPEDAAPVAPSVPASG 197
Query: 277 YEEL 280
Y EL
Sbjct: 198 YPEL 201
Score = 84.7 bits (208), Expect = 6e-16
Identities = 46/110 (41%), Positives = 60/110 (54%), Gaps = 2/110 (1%)
Query: 278 EELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTR 337
EELRL SF DWP + V LA AG F+TG +D V+CF C G L+ W+ GDDP +H +
Sbjct: 87 EELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAK 146
Query: 338 CFPNCPFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVP 387
FP+C FL K V ++ +L + E ED+ V P VP
Sbjct: 147 WFPSCQFLLRSKGRDFVHSVQETHSQLLGSWDPWEEP--EDAAPVAPSVP 194
Score = 46.2 bits (108), Expect = 2e-04
Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 1/91 (1%)
Query: 39 EEEEQKERAKMQKGYNSQ-MRSEAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQC 97
EEEE+ A + +G M SE RL +F + + P+ +AAAGF+ TG + ++C
Sbjct: 65 EEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRC 124
Query: 98 FCCSLILFGAGLTRLPIEDHKRFHPDCGFLL 128
F C L P +H ++ P C FLL
Sbjct: 125 FFCYGGLQSWKRGDDPWTEHAKWFPSCQFLL 155
Score = 30.8 bits (68), Expect = 9.6
Identities = 27/89 (30%), Positives = 33/89 (37%), Gaps = 5/89 (5%)
Query: 308 GIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNC---PFLQNMKSSAEVTPDLQSRGEL 364
G KD +C G W GD P + RC P P L A D Q G+L
Sbjct: 2 GPKDSAKCLHRGPQPSHWAAGDGPTQE--RCGPRSLGSPVLGLDTCRAWDHVDGQILGQL 59
Query: 365 CELLETTSESNLEDSIAVGPIVPEMAQGE 393
L E E +++ GP P M E
Sbjct: 60 RPLTEEEEEEGAGATLSRGPAFPGMGSEE 88
>gi|21536421 livin inhibitor of apoptosis isoform alpha [Homo
sapiens]
Length = 298
Score = 94.4 bits (233), Expect = 7e-19
Identities = 54/124 (43%), Positives = 69/124 (55%), Gaps = 11/124 (8%)
Query: 159 EEARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHA 218
EE RLASF +WP + + P +L+ AGF TG QD V+CF C G L +W+ GDDPW EHA
Sbjct: 87 EELRLASFYDWPLTAE-VPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHA 145
Query: 219 KWFPKCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFA-- 276
KWFP C+FL K + ++ S V T + SW E P +A S+ A
Sbjct: 146 KWFPSCQFLLRSKGRD----FVHS----VQETHSQLLGSWDPWEEPEDAAPVAPSVPASG 197
Query: 277 YEEL 280
Y EL
Sbjct: 198 YPEL 201
Score = 84.7 bits (208), Expect = 6e-16
Identities = 46/110 (41%), Positives = 60/110 (54%), Gaps = 2/110 (1%)
Query: 278 EELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTR 337
EELRL SF DWP + V LA AG F+TG +D V+CF C G L+ W+ GDDP +H +
Sbjct: 87 EELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAK 146
Query: 338 CFPNCPFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVP 387
FP+C FL K V ++ +L + E ED+ V P VP
Sbjct: 147 WFPSCQFLLRSKGRDFVHSVQETHSQLLGSWDPWEEP--EDAAPVAPSVP 194
Score = 46.2 bits (108), Expect = 2e-04
Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 1/91 (1%)
Query: 39 EEEEQKERAKMQKGYNSQ-MRSEAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQC 97
EEEE+ A + +G M SE RL +F + + P+ +AAAGF+ TG + ++C
Sbjct: 65 EEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRC 124
Query: 98 FCCSLILFGAGLTRLPIEDHKRFHPDCGFLL 128
F C L P +H ++ P C FLL
Sbjct: 125 FFCYGGLQSWKRGDDPWTEHAKWFPSCQFLL 155
Score = 30.8 bits (68), Expect = 9.6
Identities = 27/89 (30%), Positives = 33/89 (37%), Gaps = 5/89 (5%)
Query: 308 GIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNC---PFLQNMKSSAEVTPDLQSRGEL 364
G KD +C G W GD P + RC P P L A D Q G+L
Sbjct: 2 GPKDSAKCLHRGPQPSHWAAGDGPTQE--RCGPRSLGSPVLGLDTCRAWDHVDGQILGQL 59
Query: 365 CELLETTSESNLEDSIAVGPIVPEMAQGE 393
L E E +++ GP P M E
Sbjct: 60 RPLTEEEEEEGAGATLSRGPAFPGMGSEE 88
>gi|44680139 baculoviral IAP repeat-containing 8 [Homo sapiens]
Length = 236
Score = 81.6 bits (200), Expect = 5e-15
Identities = 36/77 (46%), Positives = 49/77 (63%), Gaps = 3/77 (3%)
Query: 160 EARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAK 219
EARL +F W + V L+ AGF G++D VQCF CGG L NW+ +DPW++HAK
Sbjct: 5 EARLITFGTWMYSVNKEQ---LARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQHAK 61
Query: 220 WFPKCEFLRSKKSSEEI 236
W+P C++L +K E I
Sbjct: 62 WYPGCKYLLEEKGHEYI 78
Score = 62.8 bits (151), Expect = 2e-09
Identities = 41/149 (27%), Positives = 74/149 (49%), Gaps = 9/149 (6%)
Query: 279 ELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRC 338
E RL +F W +V LA+AG + G +D VQCF CGG L W+ +DP + H +
Sbjct: 5 EARLITFGTWMY--SVNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQHAKW 62
Query: 339 FPNCPFLQNMKSSAEVTPDLQSRGELCELLETTSES-----NLEDSIAVGPIVPEMAQGE 393
+P C +L K + +R L++TT ++ + D+I P++ E +
Sbjct: 63 YPGCKYLLEEKGHEYINNIHLTRSLEGALVQTTKKTPSLTKRISDTIFPNPMLQEAIRMG 122
Query: 394 AQWFQEAKNLNEQLRAAYTSASFRHMSLL 422
F++ K + E+ R + ++++ + +L
Sbjct: 123 FD-FKDVKKIMEE-RIQTSGSNYKTLEVL 149
Score = 39.7 bits (91), Expect = 0.021
Identities = 26/73 (35%), Positives = 37/73 (50%), Gaps = 12/73 (16%)
Query: 63 RLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRL-----PIEDH 117
RL TF T+ S +++A AGFY G + +QCF C G GL P E H
Sbjct: 7 RLITFGTW--MYSVNKEQLARAGFYAIGQEDKVQCFHC-----GGGLANWKPKEDPWEQH 59
Query: 118 KRFHPDCGFLLNK 130
+++P C +LL +
Sbjct: 60 AKWYPGCKYLLEE 72
>gi|59859878 baculoviral IAP repeat-containing protein 5 isoform 1
[Homo sapiens]
Length = 142
Score = 62.0 bits (149), Expect = 4e-09
Identities = 34/84 (40%), Positives = 49/84 (58%), Gaps = 6/84 (7%)
Query: 159 EEARLASFRNWPFYVQGIS--PCVLSEAGFVFT---GKQDTVQCFSCGGCLGNWEEGDDP 213
++ R+++F+NWPF ++G + P ++EAGF+ + D QCF C L WE DDP
Sbjct: 15 KDHRISTFKNWPF-LEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDP 73
Query: 214 WKEHAKWFPKCEFLRSKKSSEEIT 237
+EH K C FL KK EE+T
Sbjct: 74 IEEHKKHSSGCAFLSVKKQFEELT 97
Score = 50.8 bits (120), Expect = 9e-06
Identities = 27/80 (33%), Positives = 41/80 (51%), Gaps = 5/80 (6%)
Query: 281 RLDSFKDWP--RESAVGVAALAKAGLFYTGIK---DIVQCFSCGGCLEKWQEGDDPLDDH 335
R+ +FK+WP A +A+AG + + D+ QCF C LE W+ DDP+++H
Sbjct: 18 RISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEH 77
Query: 336 TRCFPNCPFLQNMKSSAEVT 355
+ C FL K E+T
Sbjct: 78 KKHSSGCAFLSVKKQFEELT 97
Score = 35.4 bits (80), Expect = 0.39
Identities = 31/94 (32%), Positives = 40/94 (42%), Gaps = 10/94 (10%)
Query: 78 PQEMAAAGFYFTGVKSG---IQCFCCSLILFGAGLTRLPIEDHKRFHPDCGFLLNK---- 130
P+ MA AGF ++ QCF C L G PIE+HK+ C FL K
Sbjct: 35 PERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFE 94
Query: 131 --DVGNIAKYD-IRVKNLKSRLRGGKMRYQEEEA 161
+G K D R KN ++ K + EE A
Sbjct: 95 ELTLGEFLKLDRERAKNKIAKETNNKKKEFEETA 128
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 61.2 bits (147), Expect = 7e-09
Identities = 82/369 (22%), Positives = 151/369 (40%), Gaps = 41/369 (11%)
Query: 448 PVQEPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLS 507
P P VLP G + + + G AG GKT L +K+ WA L+++F+ FYLS
Sbjct: 194 PFSNPRVLP---GPFSYTVVLYGPAGLGKTTLAQKLMLDWAED--NLIHKFKYAFYLSC- 247
Query: 508 STRPDEGLASIICDQLLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKE-----------I 556
R L +L+ ++ + + +I+ Q + ++LF++D + E I
Sbjct: 248 --RELSRLGPCSFAELVFRDWPELQDDIPHILAQAR-KILFVIDGFDELGAAPGALIEDI 304
Query: 557 CS-------IPQVIGKLIQKNHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNT 607
C +P ++G L+ + L + LL+ R RD+R E + ++ F +
Sbjct: 305 CGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDR 364
Query: 608 VCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVF 667
+ F +R F + N +L ++ P +C + + D V
Sbjct: 365 RAYFLRHFGDEDQAMRAFEL-MRSNAALFQLGSAPAVCWIVCT-TLKLQMEKGEDPVPTC 422
Query: 668 KS----YMERLSLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDL 723
+ ++ L R A+ L+ + + LA +G ++ + +DL GV E DL
Sbjct: 423 LTRTGLFLRFLCSRFPQGAQ-LRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQE-SDL 480
Query: 724 TMCLMSKFTAQR--LRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINSP 781
+ L Q + Y F+ +FQ+FL L L+ + +E +D + + +
Sbjct: 481 RLFLDGDILRQDRVSKGCYSFIHLSFQQFLTA--LFYTLEKEEEEDRDGHTWDIGDVQKL 538
Query: 782 MMTVSAYNN 790
+ V N
Sbjct: 539 LSGVERLRN 547
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 57.8 bits (138), Expect = 7e-08
Identities = 78/338 (23%), Positives = 132/338 (39%), Gaps = 51/338 (15%)
Query: 465 VMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLL 524
++ ++G AG GK+ L +++ W G +RFQ VFY S + ++ +L+
Sbjct: 329 IVILQGAAGIGKSTLARQVKEAWGRGQL-YGDRFQHVFYFSCRELAQSKVVSLA---ELI 384
Query: 525 EKEGSVTEMCVRNIIQQLKNQVLFLLDDY-----------KEIC---SIPQ----VIGKL 566
K+G+ T +R I+ + ++LF+LD E+C S PQ ++G L
Sbjct: 385 GKDGTATPAPIRQILSR-PERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSL 443
Query: 567 IQKNHLSRTCLLIAVRTNRARDIRRYLETI--LEIKAFPFYNTVCILRKLFSHNMTRLRK 624
+ K L LI RT +++ LE +E+ F + + F+ +R
Sbjct: 444 LGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRA 503
Query: 625 FMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKAT--- 681
F + N+ L + P C Q E+L+L +K T
Sbjct: 504 FRLV-KSNKELWALCLVPWVSWLACTCLMQQ------------MKRKEKLTLTSKTTTTL 550
Query: 682 ----------AEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKF 731
A+ L + LA +G + F+ DDL + G+D T M
Sbjct: 551 CLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL 610
Query: 732 TAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQD 769
+ Y F+ FQEF A M + + R +H +
Sbjct: 611 QEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSN 648
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 57.8 bits (138), Expect = 7e-08
Identities = 78/338 (23%), Positives = 132/338 (39%), Gaps = 51/338 (15%)
Query: 465 VMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLL 524
++ ++G AG GK+ L +++ W G +RFQ VFY S + ++ +L+
Sbjct: 329 IVILQGAAGIGKSTLARQVKEAWGRGQL-YGDRFQHVFYFSCRELAQSKVVSLA---ELI 384
Query: 525 EKEGSVTEMCVRNIIQQLKNQVLFLLDDY-----------KEIC---SIPQ----VIGKL 566
K+G+ T +R I+ + ++LF+LD E+C S PQ ++G L
Sbjct: 385 GKDGTATPAPIRQILSR-PERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSL 443
Query: 567 IQKNHLSRTCLLIAVRTNRARDIRRYLETI--LEIKAFPFYNTVCILRKLFSHNMTRLRK 624
+ K L LI RT +++ LE +E+ F + + F+ +R
Sbjct: 444 LGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRA 503
Query: 625 FMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKAT--- 681
F + N+ L + P C Q E+L+L +K T
Sbjct: 504 FRLV-KSNKELWALCLVPWVSWLACTCLMQQ------------MKRKEKLTLTSKTTTTL 550
Query: 682 ----------AEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKF 731
A+ L + LA +G + F+ DDL + G+D T M
Sbjct: 551 CLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL 610
Query: 732 TAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQD 769
+ Y F+ FQEF A M + + R +H +
Sbjct: 611 QEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSN 648
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 57.8 bits (138), Expect = 7e-08
Identities = 78/338 (23%), Positives = 132/338 (39%), Gaps = 51/338 (15%)
Query: 465 VMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLL 524
++ ++G AG GK+ L +++ W G +RFQ VFY S + ++ +L+
Sbjct: 329 IVILQGAAGIGKSTLARQVKEAWGRGQL-YGDRFQHVFYFSCRELAQSKVVSLA---ELI 384
Query: 525 EKEGSVTEMCVRNIIQQLKNQVLFLLDDY-----------KEIC---SIPQ----VIGKL 566
K+G+ T +R I+ + ++LF+LD E+C S PQ ++G L
Sbjct: 385 GKDGTATPAPIRQILSR-PERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSL 443
Query: 567 IQKNHLSRTCLLIAVRTNRARDIRRYLETI--LEIKAFPFYNTVCILRKLFSHNMTRLRK 624
+ K L LI RT +++ LE +E+ F + + F+ +R
Sbjct: 444 LGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRA 503
Query: 625 FMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKAT--- 681
F + N+ L + P C Q E+L+L +K T
Sbjct: 504 FRLV-KSNKELWALCLVPWVSWLACTCLMQQ------------MKRKEKLTLTSKTTTTL 550
Query: 682 ----------AEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKF 731
A+ L + LA +G + F+ DDL + G+D T M
Sbjct: 551 CLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL 610
Query: 732 TAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQD 769
+ Y F+ FQEF A M + + R +H +
Sbjct: 611 QEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSN 648
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 57.8 bits (138), Expect = 7e-08
Identities = 78/338 (23%), Positives = 132/338 (39%), Gaps = 51/338 (15%)
Query: 465 VMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLL 524
++ ++G AG GK+ L +++ W G +RFQ VFY S + ++ +L+
Sbjct: 329 IVILQGAAGIGKSTLARQVKEAWGRGQL-YGDRFQHVFYFSCRELAQSKVVSLA---ELI 384
Query: 525 EKEGSVTEMCVRNIIQQLKNQVLFLLDDY-----------KEIC---SIPQ----VIGKL 566
K+G+ T +R I+ + ++LF+LD E+C S PQ ++G L
Sbjct: 385 GKDGTATPAPIRQILSR-PERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSL 443
Query: 567 IQKNHLSRTCLLIAVRTNRARDIRRYLETI--LEIKAFPFYNTVCILRKLFSHNMTRLRK 624
+ K L LI RT +++ LE +E+ F + + F+ +R
Sbjct: 444 LGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRA 503
Query: 625 FMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKAT--- 681
F + N+ L + P C Q E+L+L +K T
Sbjct: 504 FRLV-KSNKELWALCLVPWVSWLACTCLMQQ------------MKRKEKLTLTSKTTTTL 550
Query: 682 ----------AEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKF 731
A+ L + LA +G + F+ DDL + G+D T M
Sbjct: 551 CLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL 610
Query: 732 TAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQD 769
+ Y F+ FQEF A M + + R +H +
Sbjct: 611 QEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSN 648
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 57.8 bits (138), Expect = 7e-08
Identities = 78/338 (23%), Positives = 132/338 (39%), Gaps = 51/338 (15%)
Query: 465 VMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLL 524
++ ++G AG GK+ L +++ W G +RFQ VFY S + ++ +L+
Sbjct: 329 IVILQGAAGIGKSTLARQVKEAWGRGQL-YGDRFQHVFYFSCRELAQSKVVSLA---ELI 384
Query: 525 EKEGSVTEMCVRNIIQQLKNQVLFLLDDY-----------KEIC---SIPQ----VIGKL 566
K+G+ T +R I+ + ++LF+LD E+C S PQ ++G L
Sbjct: 385 GKDGTATPAPIRQILSR-PERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSL 443
Query: 567 IQKNHLSRTCLLIAVRTNRARDIRRYLETI--LEIKAFPFYNTVCILRKLFSHNMTRLRK 624
+ K L LI RT +++ LE +E+ F + + F+ +R
Sbjct: 444 LGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRA 503
Query: 625 FMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKAT--- 681
F + N+ L + P C Q E+L+L +K T
Sbjct: 504 FRLV-KSNKELWALCLVPWVSWLACTCLMQQ------------MKRKEKLTLTSKTTTTL 550
Query: 682 ----------AEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKF 731
A+ L + LA +G + F+ DDL + G+D T M
Sbjct: 551 CLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL 610
Query: 732 TAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQD 769
+ Y F+ FQEF A M + + R +H +
Sbjct: 611 QEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSN 648
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 55.1 bits (131), Expect = 5e-07
Identities = 83/338 (24%), Positives = 135/338 (39%), Gaps = 49/338 (14%)
Query: 453 LVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTR-- 510
L P+ G + ++G G GKT LL K+ W+ +RF FY R
Sbjct: 138 LFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKI-FRDRFLYTFYFCCRELREL 196
Query: 511 PDEGLASIICDQLLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEI-----------CS- 558
P LA +I + + +TE I+ Q ++LF++D ++E+ C
Sbjct: 197 PPTSLADLISREWPDPAAPITE-----IVSQ-PERLLFVIDSFEELQGGLNEPDSDLCGD 250
Query: 559 ------IPQVIGKLIQKNHLSRTCLLIAVRTNRARDIRRYLETILEIKAFPFYNTV--CI 610
+ ++ L++K L LLIA++ +++R + TI EI +N +
Sbjct: 251 LMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQV-TISEIYQPRGFNESDRLV 309
Query: 611 LRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHW---FQYPFDPSF---DDV 664
F + R + +++ L I + PL +C Q D +
Sbjct: 310 YFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTT 369
Query: 665 AVFKSYMERLSLRNKA------TAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVD 718
+V+ S++ L A T LKA S LA +G ++ FEF +DDL GV
Sbjct: 370 SVYSSFVFNLFTPEGAEGPTPQTQHQLKALCS----LAAEGMWTDTFEFCEDDLRRNGV- 424
Query: 719 EDEDLTMCLMSKFTAQ--RLRPFYRFLSPAFQEFLAGM 754
D D+ L +K + Y FL QEF A +
Sbjct: 425 VDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAAL 462
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 53.5 bits (127), Expect = 1e-06
Identities = 73/325 (22%), Positives = 126/325 (38%), Gaps = 57/325 (17%)
Query: 468 VEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKE 527
+EG G GKT LL+K+ WA G +RF VF+L++ G+A +LL ++
Sbjct: 150 LEGPDGIGKTTLLRKVMLDWAEGNL-WKDRFTFVFFLNVCEM---NGIAETSLLELLSRD 205
Query: 528 GSVTEMCVRNIIQQLKNQVLFLL-----------------DDYKEICSIPQVIGKLIQKN 570
+ + +I Q ++LF++ DD+++ +P ++ L+QK
Sbjct: 206 WPESSEKIEDIFSQ-PERILFIMDGFEQLKFNLQLKADLSDDWRQRQPMPIILSSLLQKK 264
Query: 571 HLSRTCLLIAVRTNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFG 630
L + LLIA L + K + +++ L + F +FG
Sbjct: 265 MLPESSLLIA------------LGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFG 312
Query: 631 KNQSLQKI-----QKTPLFVAA--------ICA---HWFQYPFDPSFDDVAVFKSYMERL 674
+ K+ PLF+ +C + D + Y L
Sbjct: 313 EKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFL 372
Query: 675 SLRNKATAE-----ILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMS 729
+ KA ++ + +A + S LA +G ++ F F+ DL G+ E E + M
Sbjct: 373 TTVFKAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMR 432
Query: 730 KFTAQRLRPFYRFLSPAFQEFLAGM 754
QR + F+ QEF A M
Sbjct: 433 --LLQRRGDCFAFMHLCIQEFCAAM 455
>gi|153792694 baculoviral IAP repeat-containing 6 [Homo sapiens]
Length = 4857
Score = 53.1 bits (126), Expect = 2e-06
Identities = 25/76 (32%), Positives = 38/76 (50%), Gaps = 4/76 (5%)
Query: 159 EEARLASFRNWPFY-VQGISPCVLSEAGFVF---TGKQDTVQCFSCGGCLGNWEEGDDPW 214
E R +F +WP + P +++AGF + D CF+C CL WE D+PW
Sbjct: 286 EANRRETFTSWPHVGYRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPW 345
Query: 215 KEHAKWFPKCEFLRSK 230
EH + P C F++ +
Sbjct: 346 SEHERHSPNCPFVKGE 361
Score = 48.9 bits (115), Expect = 3e-05
Identities = 27/82 (32%), Positives = 40/82 (48%), Gaps = 11/82 (13%)
Query: 273 SIFAYEELRLDSFKDWPRESAVGVA-----ALAKAGLFYTGIK---DIVQCFSCGGCLEK 324
S+ E R ++F WP VG +A+AG ++ D CF+C CL
Sbjct: 281 SLMYSEANRRETFTSWPH---VGYRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVC 337
Query: 325 WQEGDDPLDDHTRCFPNCPFLQ 346
W+ D+P +H R PNCPF++
Sbjct: 338 WEPTDEPWSEHERHSPNCPFVK 359
Score = 46.6 bits (109), Expect = 2e-04
Identities = 31/86 (36%), Positives = 41/86 (47%), Gaps = 5/86 (5%)
Query: 55 SQMRSEAKRLKTFVTYEPYS-SWI-PQEMAAAGFYFTGVKSG---IQCFCCSLILFGAGL 109
S M SEA R +TF ++ W P MA AGFY SG CF CS+ L
Sbjct: 281 SLMYSEANRRETFTSWPHVGYRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEP 340
Query: 110 TRLPIEDHKRFHPDCGFLLNKDVGNI 135
T P +H+R P+C F+ + N+
Sbjct: 341 TDEPWSEHERHSPNCPFVKGEHTQNV 366
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
Length = 1037
Score = 52.4 bits (124), Expect = 3e-06
Identities = 73/328 (22%), Positives = 131/328 (39%), Gaps = 38/328 (11%)
Query: 468 VEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKE 527
+ G AG GKT L KK W C L + FYLS + +L+ K+
Sbjct: 176 LHGPAGVGKTTLAKKCMLDWTD--CNLSPTLRYAFYLSCKEL---SRMGPCSFAELISKD 230
Query: 528 GSVTEMCVRNIIQQLKNQVLFLLDDYKE-----------ICS-------IPQVIGKLIQK 569
+ + +I+ Q + ++LF++D E IC +P ++G L+++
Sbjct: 231 WPELQDDIPSILAQAQ-RILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKR 289
Query: 570 NHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTRLRKFMV 627
L R LL+ R RD++ + + ++ F + + F +R F +
Sbjct: 290 KMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFEL 349
Query: 628 YFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKS----YMERLSLRNKATAE 683
N +L ++ P +C + + D V + ++ L R A+
Sbjct: 350 -MRSNAALFQLGSAPAVCWIVCT-TLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQ 407
Query: 684 ILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQR--LRPFYR 741
L+ + + LA +G ++ F+ +DL GV E DL + L Q + Y
Sbjct: 408 -LRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQE-SDLRLFLDGDILRQDRVSKGCYS 465
Query: 742 FLSPAFQEFLAGMRLIELLDSDRQEHQD 769
F+ +FQ+FL L L+ + E +D
Sbjct: 466 FIHLSFQQFLTA--LFYALEKEEGEDRD 491
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 52.4 bits (124), Expect = 3e-06
Identities = 73/328 (22%), Positives = 131/328 (39%), Gaps = 38/328 (11%)
Query: 468 VEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKE 527
+ G AG GKT L KK W C L + FYLS + +L+ K+
Sbjct: 176 LHGPAGVGKTTLAKKCMLDWTD--CNLSPTLRYAFYLSCKEL---SRMGPCSFAELISKD 230
Query: 528 GSVTEMCVRNIIQQLKNQVLFLLDDYKE-----------ICS-------IPQVIGKLIQK 569
+ + +I+ Q + ++LF++D E IC +P ++G L+++
Sbjct: 231 WPELQDDIPSILAQAQ-RILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKR 289
Query: 570 NHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTRLRKFMV 627
L R LL+ R RD++ + + ++ F + + F +R F +
Sbjct: 290 KMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFEL 349
Query: 628 YFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKS----YMERLSLRNKATAE 683
N +L ++ P +C + + D V + ++ L R A+
Sbjct: 350 -MRSNAALFQLGSAPAVCWIVCT-TLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQ 407
Query: 684 ILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQR--LRPFYR 741
L+ + + LA +G ++ F+ +DL GV E DL + L Q + Y
Sbjct: 408 -LRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQE-SDLRLFLDGDILRQDRVSKGCYS 465
Query: 742 FLSPAFQEFLAGMRLIELLDSDRQEHQD 769
F+ +FQ+FL L L+ + E +D
Sbjct: 466 FIHLSFQQFLTA--LFYALEKEEGEDRD 491
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 52.4 bits (124), Expect = 3e-06
Identities = 73/328 (22%), Positives = 131/328 (39%), Gaps = 38/328 (11%)
Query: 468 VEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKE 527
+ G AG GKT L KK W C L + FYLS + +L+ K+
Sbjct: 176 LHGPAGVGKTTLAKKCMLDWTD--CNLSPTLRYAFYLSCKEL---SRMGPCSFAELISKD 230
Query: 528 GSVTEMCVRNIIQQLKNQVLFLLDDYKE-----------ICS-------IPQVIGKLIQK 569
+ + +I+ Q + ++LF++D E IC +P ++G L+++
Sbjct: 231 WPELQDDIPSILAQAQ-RILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKR 289
Query: 570 NHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTRLRKFMV 627
L R LL+ R RD++ + + ++ F + + F +R F +
Sbjct: 290 KMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFEL 349
Query: 628 YFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKS----YMERLSLRNKATAE 683
N +L ++ P +C + + D V + ++ L R A+
Sbjct: 350 -MRSNAALFQLGSAPAVCWIVCT-TLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQ 407
Query: 684 ILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQR--LRPFYR 741
L+ + + LA +G ++ F+ +DL GV E DL + L Q + Y
Sbjct: 408 -LRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQE-SDLRLFLDGDILRQDRVSKGCYS 465
Query: 742 FLSPAFQEFLAGMRLIELLDSDRQEHQD 769
F+ +FQ+FL L L+ + E +D
Sbjct: 466 FIHLSFQQFLTA--LFYALEKEEGEDRD 491
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 52.4 bits (124), Expect = 3e-06
Identities = 76/322 (23%), Positives = 127/322 (39%), Gaps = 41/322 (12%)
Query: 468 VEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLS---LSSTRPDEGLASIICDQLL 524
++G AG GK++L K+ WA G RF +FY++ ++ + + + +I
Sbjct: 215 MQGAAGIGKSMLAHKVMLDWADGKL-FQGRFDYLFYINCREMNQSATECSMQDLIFSCWP 273
Query: 525 EKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEI---CSIPQ---------------VIGKL 566
E + E+ ++ ++LF++D + E+ PQ ++ L
Sbjct: 274 EPSAPLQELI------RVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSL 327
Query: 567 IQKNHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTRLRK 624
I+K L LLI R + R LE +EI F K F HN + +
Sbjct: 328 IRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYF-HNAEQAGQ 386
Query: 625 FMVYFGKNQSLQKIQKTPLFVAAICAHWFQ------YPFDPSFDDVAVFKSYMERLSLRN 678
Y N+ L + PL +C Q S AV+ Y+ L ++
Sbjct: 387 VFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSL-MQP 445
Query: 679 KATAEILKATVSSCG--ELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQ-R 735
K A L+ + G LA G ++ F + DL + G+D ++ M+ F
Sbjct: 446 KPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDIN 505
Query: 736 LRPFYRFLSPAFQEFLAGMRLI 757
+Y F+ +FQEF A M I
Sbjct: 506 CERYYSFIHLSFQEFFAAMYYI 527
>gi|113205085 leucine rich repeat containing 31 [Homo sapiens]
Length = 552
Score = 49.7 bits (117), Expect = 2e-05
Identities = 86/352 (24%), Positives = 142/352 (40%), Gaps = 39/352 (11%)
Query: 1041 IESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVS------GTIQSQDQI 1094
++ + ++ + CS++ + + Q LL L SLE L++S G++ S Q
Sbjct: 191 LQKFQKGSKIQMIELVDCSLTSEDGTFLGQ-LLPMLQSLEVLDLSINRDIVGSLNSIAQG 249
Query: 1095 FPNLDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISA------EYDPSKLV 1148
+ LK S L ++ F + KL + + E P++LV
Sbjct: 250 LKSTSNLKVLKLHSCGLSQKS--VKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLV 307
Query: 1149 KLIQNSPNLHVFHL-KCNFFSDFGSLMTMLVSC-KKLTEI------KFSDSFFQAVPFVA 1200
L +L V L +C+ +D +T ++ L E+ K S + +
Sbjct: 308 ML----KHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLR 363
Query: 1201 SLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQ 1260
LP SL I N + ET A LS LE L + KL+++ +
Sbjct: 364 FLPALKSLVINNCA----LESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLK 419
Query: 1261 QLHCLRVLSFFK-TLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEEGYRNFFQALDN 1319
L+VL +L + V +A V +G KL+ L LS N I + G+ F Q +
Sbjct: 420 LSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVRF 479
Query: 1320 MPNLQELDIS---RHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDA 1368
+ L ELDIS +F +C + L V +LP++ + M W+L A
Sbjct: 480 LKELIELDISLRPSNFRDC----GQWFRHLLYAVTKLPQITEIGMKRWILPA 527
>gi|59859882 baculoviral IAP repeat-containing protein 5 isoform 3
[Homo sapiens]
Length = 165
Score = 48.9 bits (115), Expect = 3e-05
Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 29/107 (27%)
Query: 159 EEARLASFRNWPFYVQGIS--PCVLSEAGFVFT---GKQDTVQCFSCGGCLGNWEEGDDP 213
++ R+++F+NWPF ++G + P ++EAGF+ + D QCF C L WE DDP
Sbjct: 15 KDHRISTFKNWPF-LEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDP 73
Query: 214 -----------------------WKEHAKWFPKCEFLRSKKSSEEIT 237
+EH K C FL KK EE+T
Sbjct: 74 IGPGTVAYACNTSTLGGRGGRITREEHKKHSSGCAFLSVKKQFEELT 120
Score = 38.1 bits (87), Expect = 0.060
Identities = 21/61 (34%), Positives = 31/61 (50%), Gaps = 5/61 (8%)
Query: 281 RLDSFKDWP--RESAVGVAALAKAGLFYTGIK---DIVQCFSCGGCLEKWQEGDDPLDDH 335
R+ +FK+WP A +A+AG + + D+ QCF C LE W+ DDP+
Sbjct: 18 RISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIGPG 77
Query: 336 T 336
T
Sbjct: 78 T 78
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 46.2 bits (108), Expect = 2e-04
Identities = 75/321 (23%), Positives = 124/321 (38%), Gaps = 48/321 (14%)
Query: 469 EGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEG 528
+G AG GKT+L +K+ WASG +RF +FY+ S++ + L G
Sbjct: 225 QGAAGIGKTILARKMMLDWASGTL-YQDRFDYLFYIHCRE-------VSLVTQRSL---G 273
Query: 529 SVTEMC-------VRNIIQQLKNQVLFLLDDYKE-----------ICSIPQ-------VI 563
+ C + I+++ +++LFL+D + E +C+ Q ++
Sbjct: 274 DLIMSCCPDPNPPIHKIVRK-PSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILL 332
Query: 564 GKLIQKNHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTR 621
LI+K L LLI R ++ L+ +EI F K FS + +
Sbjct: 333 SSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFS-DEAQ 391
Query: 622 LRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYP------FDPSFDDVAVFKSYMER-L 674
R +N+ L + PL +C Q S AV+ ++ L
Sbjct: 392 ARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLL 451
Query: 675 SLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQ 734
R + L A + LA G ++ F + DL G+ + + M+ F +
Sbjct: 452 QPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKE 511
Query: 735 -RLRPFYRFLSPAFQEFLAGM 754
FY F+ FQEF A M
Sbjct: 512 VDCEKFYSFIHMTFQEFFAAM 532
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 46.2 bits (108), Expect = 2e-04
Identities = 75/321 (23%), Positives = 124/321 (38%), Gaps = 48/321 (14%)
Query: 469 EGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEG 528
+G AG GKT+L +K+ WASG +RF +FY+ S++ + L G
Sbjct: 225 QGAAGIGKTILARKMMLDWASGTL-YQDRFDYLFYIHCRE-------VSLVTQRSL---G 273
Query: 529 SVTEMC-------VRNIIQQLKNQVLFLLDDYKE-----------ICSIPQ-------VI 563
+ C + I+++ +++LFL+D + E +C+ Q ++
Sbjct: 274 DLIMSCCPDPNPPIHKIVRK-PSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILL 332
Query: 564 GKLIQKNHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTR 621
LI+K L LLI R ++ L+ +EI F K FS + +
Sbjct: 333 SSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFS-DEAQ 391
Query: 622 LRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYP------FDPSFDDVAVFKSYMER-L 674
R +N+ L + PL +C Q S AV+ ++ L
Sbjct: 392 ARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLL 451
Query: 675 SLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQ 734
R + L A + LA G ++ F + DL G+ + + M+ F +
Sbjct: 452 QPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKE 511
Query: 735 -RLRPFYRFLSPAFQEFLAGM 754
FY F+ FQEF A M
Sbjct: 512 VDCEKFYSFIHMTFQEFFAAM 532
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 46.2 bits (108), Expect = 2e-04
Identities = 75/321 (23%), Positives = 124/321 (38%), Gaps = 48/321 (14%)
Query: 469 EGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEG 528
+G AG GKT+L +K+ WASG +RF +FY+ S++ + L G
Sbjct: 225 QGAAGIGKTILARKMMLDWASGTL-YQDRFDYLFYIHCRE-------VSLVTQRSL---G 273
Query: 529 SVTEMC-------VRNIIQQLKNQVLFLLDDYKE-----------ICSIPQ-------VI 563
+ C + I+++ +++LFL+D + E +C+ Q ++
Sbjct: 274 DLIMSCCPDPNPPIHKIVRK-PSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILL 332
Query: 564 GKLIQKNHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTR 621
LI+K L LLI R ++ L+ +EI F K FS + +
Sbjct: 333 SSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFS-DEAQ 391
Query: 622 LRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYP------FDPSFDDVAVFKSYMER-L 674
R +N+ L + PL +C Q S AV+ ++ L
Sbjct: 392 ARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLL 451
Query: 675 SLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQ 734
R + L A + LA G ++ F + DL G+ + + M+ F +
Sbjct: 452 QPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKE 511
Query: 735 -RLRPFYRFLSPAFQEFLAGM 754
FY F+ FQEF A M
Sbjct: 512 VDCEKFYSFIHMTFQEFFAAM 532
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 46.2 bits (108), Expect = 2e-04
Identities = 75/321 (23%), Positives = 124/321 (38%), Gaps = 48/321 (14%)
Query: 469 EGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEG 528
+G AG GKT+L +K+ WASG +RF +FY+ S++ + L G
Sbjct: 225 QGAAGIGKTILARKMMLDWASGTL-YQDRFDYLFYIHCRE-------VSLVTQRSL---G 273
Query: 529 SVTEMC-------VRNIIQQLKNQVLFLLDDYKE-----------ICSIPQ-------VI 563
+ C + I+++ +++LFL+D + E +C+ Q ++
Sbjct: 274 DLIMSCCPDPNPPIHKIVRK-PSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILL 332
Query: 564 GKLIQKNHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTR 621
LI+K L LLI R ++ L+ +EI F K FS + +
Sbjct: 333 SSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFS-DEAQ 391
Query: 622 LRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYP------FDPSFDDVAVFKSYMER-L 674
R +N+ L + PL +C Q S AV+ ++ L
Sbjct: 392 ARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLL 451
Query: 675 SLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQ 734
R + L A + LA G ++ F + DL G+ + + M+ F +
Sbjct: 452 QPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKE 511
Query: 735 -RLRPFYRFLSPAFQEFLAGM 754
FY F+ FQEF A M
Sbjct: 512 VDCEKFYSFIHMTFQEFFAAM 532
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,455,315
Number of Sequences: 37866
Number of extensions: 2190949
Number of successful extensions: 6460
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 6312
Number of HSP's gapped (non-prelim): 122
length of query: 1403
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1288
effective length of database: 13,892,928
effective search space: 17894091264
effective search space used: 17894091264
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.