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Search of human proteins with 239756174
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239756174 PREDICTED: hypothetical protein [Homo sapiens]
(625 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239756174 PREDICTED: hypothetical protein [Homo sapiens] 1201 0.0
gi|239750672 PREDICTED: hypothetical protein [Homo sapiens] 1194 0.0
gi|239744982 PREDICTED: hypothetical protein [Homo sapiens] 1194 0.0
gi|148746195 trichohyalin [Homo sapiens] 101 2e-21
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 96 1e-19
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 91 4e-18
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 89 2e-17
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 88 2e-17
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 87 6e-17
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 86 8e-17
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 86 8e-17
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 86 8e-17
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 86 8e-17
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] 81 3e-15
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 80 4e-15
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 79 1e-14
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 79 1e-14
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 79 1e-14
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 79 1e-14
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 79 1e-14
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 79 1e-14
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 79 1e-14
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 79 1e-14
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 78 2e-14
gi|224593756 hypothetical protein LOC164127 [Homo sapiens] 77 4e-14
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 77 5e-14
gi|219803769 trichoplein [Homo sapiens] 74 3e-13
gi|14150056 trichoplein [Homo sapiens] 74 3e-13
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti... 73 9e-13
gi|56549694 enabled homolog isoform a [Homo sapiens] 72 1e-12
>gi|239756174 PREDICTED: hypothetical protein [Homo sapiens]
Length = 625
Score = 1201 bits (3107), Expect = 0.0
Identities = 625/625 (100%), Positives = 625/625 (100%)
Query: 1 MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60
MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS
Sbjct: 1 MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60
Query: 61 ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120
ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC
Sbjct: 61 ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120
Query: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERDRIMREEKRRL 180
AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERDRIMREEKRRL
Sbjct: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERDRIMREEKRRL 180
Query: 181 FTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAGSR 240
FTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAGSR
Sbjct: 181 FTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAGSR 240
Query: 241 TGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTN 300
TGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTN
Sbjct: 241 TGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTN 300
Query: 301 APGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALM 360
APGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALM
Sbjct: 301 APGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALM 360
Query: 361 LARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGR 420
LARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGR
Sbjct: 361 LARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGR 420
Query: 421 RGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE 480
RGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE
Sbjct: 421 RGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE 480
Query: 481 EGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ 540
EGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ
Sbjct: 481 EGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ 540
Query: 541 EREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKV 600
EREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKV
Sbjct: 541 EREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKV 600
Query: 601 REETNTRSFDRMVREAQLHASLDRK 625
REETNTRSFDRMVREAQLHASLDRK
Sbjct: 601 REETNTRSFDRMVREAQLHASLDRK 625
>gi|239750672 PREDICTED: hypothetical protein [Homo sapiens]
Length = 627
Score = 1194 bits (3090), Expect = 0.0
Identities = 624/627 (99%), Positives = 625/627 (99%), Gaps = 2/627 (0%)
Query: 1 MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60
MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS
Sbjct: 1 MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60
Query: 61 ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120
ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC
Sbjct: 61 ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120
Query: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERDRIMREEKRRL 180
AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAER+RIMREEKRRL
Sbjct: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL 180
Query: 181 FTPLSPAAAAAAAAA--SAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 238
FTPLSPAAAAAAAAA SAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG
Sbjct: 181 FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 240
Query: 239 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 298
SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST
Sbjct: 241 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 300
Query: 299 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 358
TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA
Sbjct: 301 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 360
Query: 359 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 418
LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR
Sbjct: 361 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 420
Query: 419 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 478
GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ
Sbjct: 421 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 480
Query: 479 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 538
REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ
Sbjct: 481 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540
Query: 539 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 598
RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE
Sbjct: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 600
Query: 599 KVREETNTRSFDRMVREAQLHASLDRK 625
KVREETNTRSFDRMVREAQLHASLDRK
Sbjct: 601 KVREETNTRSFDRMVREAQLHASLDRK 627
>gi|239744982 PREDICTED: hypothetical protein [Homo sapiens]
Length = 627
Score = 1194 bits (3090), Expect = 0.0
Identities = 624/627 (99%), Positives = 625/627 (99%), Gaps = 2/627 (0%)
Query: 1 MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60
MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS
Sbjct: 1 MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60
Query: 61 ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120
ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC
Sbjct: 61 ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120
Query: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERDRIMREEKRRL 180
AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAER+RIMREEKRRL
Sbjct: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL 180
Query: 181 FTPLSPAAAAAAAAA--SAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 238
FTPLSPAAAAAAAAA SAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG
Sbjct: 181 FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 240
Query: 239 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 298
SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST
Sbjct: 241 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 300
Query: 299 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 358
TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA
Sbjct: 301 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 360
Query: 359 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 418
LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR
Sbjct: 361 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 420
Query: 419 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 478
GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ
Sbjct: 421 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 480
Query: 479 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 538
REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ
Sbjct: 481 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540
Query: 539 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 598
RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE
Sbjct: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 600
Query: 599 KVREETNTRSFDRMVREAQLHASLDRK 625
KVREETNTRSFDRMVREAQLHASLDRK
Sbjct: 601 KVREETNTRSFDRMVREAQLHASLDRK 627
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 101 bits (251), Expect = 2e-21
Identities = 83/266 (31%), Positives = 134/266 (50%), Gaps = 21/266 (7%)
Query: 351 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRR-A 409
ER R+ L +E L EQ+ + ELQR EEREK+R EQ R+
Sbjct: 881 ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQR---------EEREKRRRQEQERQYR 931
Query: 410 WAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRK 469
Q+++ + REERE RR++R ER + ++L +++ L E E+ R++R +K
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQER--ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989
Query: 470 LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEA 529
++E+ L+Q EE L RE E+ RR+ +R + R++ +LQ+E+ +L R ER +
Sbjct: 990 YREEEELQQEEEQLL--REEREKRRRQEWER----QYRKKDELQQEEEQLLREEREKRR- 1042
Query: 530 LLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARST 589
LQ R RQ R+E E L+ E LG +E + R+ + E+L +E L
Sbjct: 1043 -LQERERQYREEEE-LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100
Query: 590 ARASFHVREKVREETNTRSFDRMVRE 615
R R+ EE + ++++RE
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLRE 1126
Score = 99.8 bits (247), Expect = 7e-21
Identities = 85/283 (30%), Positives = 136/283 (48%), Gaps = 29/283 (10%)
Query: 341 RAERGLRGVPERDRKIAAL-MLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREK 399
R ERG + +RDRK L + +EE L Q + E Q+V +Q +ER+ E
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVR-RQEQERKFMED 1600
Query: 400 QRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAE 459
++ L R+ Q+ + R R+ RE+ + + R+ Q +ER R+ E + LRR+ E
Sbjct: 1601 EQQLR--RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE 1658
Query: 460 RAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKREL 519
+ R DR RK ++E+ L LQEG E +Q+RR+ R R +++Q + +RE++ L
Sbjct: 1659 QQLRHDRDRKFREEEQL------LQEGEE--QQLRRQERDRKFREEEQQLRRQERERKFL 1710
Query: 520 SRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRER 579
++ R + L ++ +E E LR E R QE Y RK+ EQL R
Sbjct: 1711 QEEQQLRRQEL-----ERKFREEEQLRQETEQEQLRRQERY------RKILEEEQL-RPE 1758
Query: 580 RSALESARSTARASFHVREKVREE-----TNTRSFDRMVREAQ 617
R + R F E++R+E ++ DR RE +
Sbjct: 1759 REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEE 1801
Score = 98.6 bits (244), Expect = 2e-20
Identities = 91/323 (28%), Positives = 150/323 (46%), Gaps = 40/323 (12%)
Query: 323 LSHSPQTAQHVERIVR-QVRAERGLRGVPERDRKIAALMLARHQE-ELLLLEQRAAAHGQ 380
LS P + ER +R + R +R R +PE + K R +E EL LE+ +
Sbjct: 784 LSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRR 843
Query: 381 WELQRVHAKQRREREEREKQRALEQGR-RAWAAQVEERRGRRG----------------- 422
Q++ ++ +E++E++R+ EQ R + W Q+EE R RR
Sbjct: 844 ERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903
Query: 423 ---REEREAARRRQRQYERSEERRRELAERQGL------LRRERAERAAREDRLRKLQQE 473
+EE E +R +R+ R +E+ R+ E + L L RE E+ R++R R+ +++
Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963
Query: 474 QNLKQREEGLQ-EGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQ 532
+ L+Q+EE L E E+ + RE+ R Q++E QL RE+RE +R R E Q
Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE----KRRRQEWERQ 1019
Query: 533 GRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARA 592
R + + Q+ E E R QE R+ E+L +E L R T R
Sbjct: 1020 YRKKDELQQEEEQLLREEREKRRLQERE------RQYREEEELQQEEEQLLGEERETRRR 1073
Query: 593 SFHVREKVREETNTRSFDRMVRE 615
R+ +EE + ++++RE
Sbjct: 1074 QELERQYRKEEELQQEEEQLLRE 1096
Score = 96.7 bits (239), Expect = 6e-20
Identities = 87/297 (29%), Positives = 145/297 (48%), Gaps = 19/297 (6%)
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLE---QRAAAHGQWELQRVHAKQ-RRE 393
R+ R +R + E++ + +L + +E+L E QR + +L+++ ++ RRE
Sbjct: 230 RRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289
Query: 394 REEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEER-RRELAERQGL 452
R+E E+Q+ + + + EE R + E RE RR++Q ER E++ RRE ER+
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQ 349
Query: 453 LRRERAERAAREDRLRKLQQEQNLKQ---REEGLQEGRE--RAEQIRRE----RAQRAAR 503
R E RE +LR+ Q+E+ +Q RE+ L+ ++ R +Q+RRE R Q+ R
Sbjct: 350 QLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 409
Query: 504 AKQ-RQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEH 562
+Q R+E QL+RE++ E RHE + R+QR +RE + L R +E H
Sbjct: 410 EQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE--QEERRDWLKREEETERH 467
Query: 563 LAIGRKLERSEQLTRERRSALESARSTARASFHVR--EKVREETNTRSFDRMVREAQ 617
RK + ERR R R +++R E R R+ R+ +
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEE 524
Score = 96.7 bits (239), Expect = 6e-20
Identities = 91/322 (28%), Positives = 148/322 (45%), Gaps = 28/322 (8%)
Query: 316 RSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRA 375
R F +L H Q + +E R R ER + + E + L +++L R
Sbjct: 1360 RKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ----LRCQEREQQLRQDRDRK 1415
Query: 376 AAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAA--QVEERRGRRGREEREAARRRQ 433
+ +L R + R+ REE ++ R E+ R+ Q+ + R R+ REE + + R+
Sbjct: 1416 FREEEQQLSR-QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQERE 1474
Query: 434 RQYERSEERRRELAERQGLLRRERAERAAREDRLRK-------LQQEQNL---KQREEGL 483
Q +ER R+ E + LRR+ +R RE LR L++EQ L +++ + L
Sbjct: 1475 EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFL 1534
Query: 484 QEGRERAEQIRRERAQRAARAKQRQEGQL--QREKRELSRAERARHEALLQGRTRQQRQE 541
QE ++ Q R ++ ++ K R+E QL +RE+++LSR ER R L + + R+Q QE
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQE 1594
Query: 542 REGLRSSLEASLGRAQENYEHL--AIGRKLERSEQLTRERRS----ALESARSTARASFH 595
R+ + + R QE + L RK EQL +ER E R
Sbjct: 1595 RKFMEDEQQL---RRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQ 1651
Query: 596 VREKVREETNTRSFDRMVREAQ 617
+R + RE+ DR RE +
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEE 1673
Score = 94.4 bits (233), Expect = 3e-19
Identities = 81/301 (26%), Positives = 136/301 (45%), Gaps = 23/301 (7%)
Query: 343 ERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQW-----ELQRVHAKQRREREER 397
+R L+ E+ RK+ L R ++E +QR Q E +R ++RRE++ER
Sbjct: 268 QRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER 327
Query: 398 EKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRE- 456
+Q+ + ++ Q E R + RE+ E R +Q + E+ EERR + R+ LRRE
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387
Query: 457 ---------RAERAAREDRLRKLQQ---EQNLKQREEGLQEGRERAEQIRRERAQRAARA 504
R ++ RE +LR+ QQ EQ L++ ++ +E E + + E+ +R R
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447
Query: 505 KQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLA 564
K+ QE + KRE ER E Q R Q +ER LE R Q+
Sbjct: 448 KREQEERRDWLKRE-EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERRE-- 504
Query: 565 IGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDR 624
++L R ++ RE+R + + +++R E R + RE + +R
Sbjct: 505 --QQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562
Query: 625 K 625
+
Sbjct: 563 R 563
Score = 90.5 bits (223), Expect = 4e-18
Identities = 82/286 (28%), Positives = 142/286 (49%), Gaps = 21/286 (7%)
Query: 341 RAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRER------ 394
R ER R E++R+ + +EE LL E+R Q E +R + K ++ +
Sbjct: 915 REEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ-ERERQYRKDKKLQQKEEQL 973
Query: 395 --EEREKQRALEQGRR-AWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 451
EE EK+R E+ ++ ++++ + REERE +RR++++ER ++ EL + +
Sbjct: 974 LGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE--KRRRQEWERQYRKKDELQQEEE 1031
Query: 452 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 511
L RE E+ ++R R+ ++E+ L+Q EE L G ER E RR+ +R + R+E +
Sbjct: 1032 QLLREEREKRRLQERERQYREEEELQQEEEQLL-GEER-ETRRRQELER----QYRKEEE 1085
Query: 512 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 571
LQ+E+ +L R E + Q R RQ R+E E L+ E L +E + R+
Sbjct: 1086 LQQEEEQLLREEPEKRRR--QERERQCREEEE-LQQEEEQLLREEREKRRRQELERQYRE 1142
Query: 572 SEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQ 617
E++ +E L R R+ EE + ++++RE Q
Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188
Score = 90.1 bits (222), Expect = 5e-18
Identities = 78/306 (25%), Positives = 140/306 (45%), Gaps = 26/306 (8%)
Query: 334 ERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRE 393
E +++ R E R RDR++ R +++ ++R A G+ + ++ ++R+
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQE-QERELAEGEEQSEKQERLEQRD 165
Query: 394 REERE----KQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAER 449
R+ R+ +QR Q R A+ E+ + +G E E Q + E RR+ E
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE 225
Query: 450 QGLLRRERAERAAREDRLR--------------KLQQEQNLKQREEGLQEGRERAEQIRR 495
+ RRER +R +E+ + KLQ+E+ +QRE LQE E+ ++ R
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE--LQEEEEQLRKLER 283
Query: 496 ERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGR 555
+ +R + +++Q+ +L+RE++ + E R E Q R+Q++ RE E L R
Sbjct: 284 QELRRERQEEEQQQQRLRREQQLRRKQEEERREQ--QEERREQQERREQQEERREQQLRR 341
Query: 556 AQENYEHLAIGRKLE---RSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRM 612
QE + R+ E R +QL RE+ + +++R E R ++
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL 401
Query: 613 VREAQL 618
RE QL
Sbjct: 402 RREQQL 407
Score = 90.1 bits (222), Expect = 5e-18
Identities = 86/300 (28%), Positives = 140/300 (46%), Gaps = 26/300 (8%)
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQEELL-LLEQRAAAHGQWELQRVHAKQRREREE 396
RQ+ E G R +R + L Q E LEQR EL R QR+E +E
Sbjct: 127 RQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWR----QRQEWQE 182
Query: 397 REKQRALEQ------GRRAWAAQVEERRGRR--------GREEREAARRRQRQYERSEER 442
RE++RA E+ G EE+ RR GREE++ RR ++ EE
Sbjct: 183 REERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEE 242
Query: 443 RRELAERQGLLRRERAERAARE-DRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRA 501
+E +R+ +LR+E + E R R+LQ+E+ ++ E + RER E+ ++++ R
Sbjct: 243 EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR 302
Query: 502 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQE--- 558
+ +R++ + +RE++E R ++ R E + R +Q R+E+E R E L R QE
Sbjct: 303 EQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR---EQQLRREQEEER 359
Query: 559 NYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQL 618
+ L ++ ER EQ R + + +++R E R ++ RE QL
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419
Score = 90.1 bits (222), Expect = 5e-18
Identities = 84/284 (29%), Positives = 139/284 (48%), Gaps = 36/284 (12%)
Query: 338 RQVRAERGLRGVPERDR-------KIAALMLARHQEEL---LLLEQRAAAHGQ----WEL 383
+Q+R E+ LR E +R + L R QEE L E+ H Q +L
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476
Query: 384 QRVHAKQRRER----EEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERS 439
+R ++RRER EE E++ E+ + + EERR +R + + E R +QR
Sbjct: 477 KRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ 536
Query: 440 EERRRELAERQGLLRRE---RAERAAREDRLRKLQQE---QNLKQREEGLQ-----EGRE 488
+ RR + R+ LL+RE R E+ RE RL++ Q+E Q LK+ EE Q E E
Sbjct: 537 QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE 596
Query: 489 RAEQ-IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRS 547
R EQ ++RE +R + ++R+E +L+RE+ E R + LL+ +++R++++ R
Sbjct: 597 RLEQRLKREEVERLEQ-EERREQRLKREE-----PEEERRQQLLKSEEQEERRQQQLRRE 650
Query: 548 SLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTAR 591
E R + E + ++L+R + R + E + AR
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694
Score = 89.7 bits (221), Expect = 7e-18
Identities = 86/293 (29%), Positives = 147/293 (50%), Gaps = 34/293 (11%)
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRE---- 393
+Q+R E+ LR R++++ R +++L +Q + ++ H ++RRE
Sbjct: 393 QQLRREQQLR----REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLK 448
Query: 394 REEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLL 453
RE+ E++ L++ + E R+ + R++ E R R + E EERR + R+ L
Sbjct: 449 REQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLE-EEERREQQERREQQL 507
Query: 454 RRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAAR-AKQRQEGQL 512
RRE+ ER RE RL++ ++E+ L+QR Q Q+RRE+ +R + K+ +E +L
Sbjct: 508 RREQEER--REQRLKRQEEEERLQQRLRSEQ-------QLRREQEERREQLLKREEEKRL 558
Query: 513 QREKRE--LSRAERARHEALL--QGRTRQQRQEREGLRSSLEASLGRAQENYEHL----A 564
++E+RE L R + R + LL + RQQR +RE LE L R E E L
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEERRQQRLKRE-QEERLEQRLKR--EEVERLEQEER 615
Query: 565 IGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQ 617
++L+R E R+ L+S R ++++R E R R+ RE +
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERR----QQQLRREQQERREQRLKREEE 664
Score = 88.2 bits (217), Expect = 2e-17
Identities = 72/236 (30%), Positives = 122/236 (51%), Gaps = 22/236 (9%)
Query: 389 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 448
+QRRER++R Q E+ + W + R + + +E +RQR+ + EE+ R+L
Sbjct: 228 QQRRERQDRVFQ---EEEEKEWRKRETVLR-KEEEKLQEEEPQRQRELQEEEEQLRKLER 283
Query: 449 RQGLLRRERAE------RAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAA 502
++ LRRER E R RE +LR+ Q+E+ +Q+EE ++ R +Q R Q
Sbjct: 284 QE--LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR 341
Query: 503 RAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEH 562
++R+E QL+RE+ E R ++ R E + R +Q R+E++ R E L R Q+
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR---EQQLRREQQ---- 394
Query: 563 LAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQL 618
L ++L R +QL RE++ E R +R + EE + + ++ RE +L
Sbjct: 395 LRREQQLRREQQLRREQQLRRE---QQLRREQQLRREQEEERHEQKHEQERREQRL 447
Score = 87.8 bits (216), Expect = 3e-17
Identities = 88/307 (28%), Positives = 143/307 (46%), Gaps = 39/307 (12%)
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 397
+Q+R E+ LR R++++ R +++L ++ + E +R + +RE+EER
Sbjct: 399 QQLRREQQLR----REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEER 454
Query: 398 -------EKQRALEQGRRAWAAQVEERRGRRGR-------EEREAARRRQRQYERSEERR 443
E+ EQ RR + ++ RR R E RE RR++Q R +E R
Sbjct: 455 RDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER 514
Query: 444 RELAERQGLLRRERAERAAR----EDRLRKLQQ---EQNLKQREEGLQEGRERAEQIRRE 496
RE Q L R+E ER + E +LR+ Q+ EQ LK+ EE E R ++++RE
Sbjct: 515 RE----QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570
Query: 497 RAQR----AARAKQRQEGQLQREKREL--SRAERARHEALLQGRTRQQRQEREGLRSSLE 550
+ +R R ++R++ +L+RE+ E R +R E L Q R+QR +RE
Sbjct: 571 QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERR 630
Query: 551 ASLGRAQENYEHLAIGRKLERSEQLTRERR--SALESARSTARASFHVREKVREETNTRS 608
L +++E E ++L R +Q RE+R E R R E+ RE+
Sbjct: 631 QQLLKSEEQEERRQ--QQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE 688
Query: 609 FDRMVRE 615
RE
Sbjct: 689 EQEQARE 695
Score = 87.4 bits (215), Expect = 4e-17
Identities = 88/315 (27%), Positives = 147/315 (46%), Gaps = 35/315 (11%)
Query: 331 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQ 390
Q R ++ R E+ LR E R+ L R QEE E+R + +L+R ++
Sbjct: 324 QQERREQQEERREQQLRREQEERRE---QQLRREQEE----ERR-----EQQLRREQEEE 371
Query: 391 RREREEREKQ--RALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 448
RRE++ R +Q R +Q RR + E++ R + RE RR++Q R ++ RRE E
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE 431
Query: 449 RQGLLRRERAERAAREDRLRKLQQEQN--LKQREEGLQEGRER--------AEQIRRER- 497
+ ++ E+ RE RL++ Q+E+ LK+ EE + +ER E+ RRER
Sbjct: 432 ER---HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Query: 498 ----AQRAARAKQRQEGQLQREKREL--SRAERARHEALLQGRTRQQRQEREGLRSSLEA 551
+ ++R+E QL+RE+ E R +R E LQ R R ++Q R E
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 552 SLGRAQE-NYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFD 610
L R +E E ++L+R ++ R++ E R R E++ + +
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608
Query: 611 RMVREAQLHASLDRK 625
R+ +E + L R+
Sbjct: 609 RLEQEERREQRLKRE 623
Score = 87.4 bits (215), Expect = 4e-17
Identities = 92/309 (29%), Positives = 154/309 (49%), Gaps = 37/309 (11%)
Query: 331 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAK- 389
Q E+++R+ R +R L+ ER+R+ + +EE LL E+R Q EL+R + K
Sbjct: 1028 QEEEQLLREEREKRRLQ---ERERQYREEEELQQEEEQLLGEERETRRRQ-ELERQYRKE 1083
Query: 390 ---QRRE----REEREKQRALEQGRRA-WAAQVEERRGRRGREEREAARRRQRQYERSEE 441
Q+ E REE EK+R E+ R+ ++++ + REERE +RR+++ ER
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE--KRRRQELERQYR 1141
Query: 442 RRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRA 501
E+ + + L RE E+ R++ R+ ++E+ L+Q EE L RE E+ R+ER +
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL--REEQEKRRQERER-- 1197
Query: 502 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQERE-GLRSSLEASLGRAQENY 560
+ R+E +LQR+KR+ +R R E Q E+E +R + GR E +
Sbjct: 1198 ---QYREEEELQRQKRK----QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQF 1250
Query: 561 EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSF---DRMVREAQ 617
R+LE S+ R+ + L+ + +E+ R + R F +++ RE Q
Sbjct: 1251 ------RQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Query: 618 LHAS-LDRK 625
A DRK
Sbjct: 1305 KEAKRRDRK 1313
Score = 86.3 bits (212), Expect = 8e-17
Identities = 84/305 (27%), Positives = 139/305 (45%), Gaps = 26/305 (8%)
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 387
Q Q E+++R+ R +R + ER+R+ + +EE LL E+ Q ++
Sbjct: 935 QLQQEEEQLLREEREKRRRQ---ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 388 AKQRRE-------REEREKQRALE---QGRRAWAAQVEERRGRRGREEREAARRRQRQYE 437
++ + REEREK+R E Q R+ Q EE + R E+ + R+RQY
Sbjct: 992 EEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYR 1051
Query: 438 RSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRER 497
EE ++E + LL ER R R++ R+ ++E+ L+Q EE L RE E+ RR+
Sbjct: 1052 EEEELQQE---EEQLLGEERETRR-RQELERQYRKEEELQQEEEQLL--REEPEKRRRQE 1105
Query: 498 AQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQ 557
+R R +E +LQ+E+ +L R ER + Q RQ R+E E ++ E L
Sbjct: 1106 RERQCR----EEEELQQEEEQLLREEREKRRR--QELERQYREEEE-VQQEEEQLLREEP 1158
Query: 558 ENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQ 617
E + R+ E+L +E L + R + + EE + + R+
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218
Query: 618 LHASL 622
+ L
Sbjct: 1219 QRSDL 1223
Score = 81.6 bits (200), Expect = 2e-15
Identities = 78/300 (26%), Positives = 141/300 (47%), Gaps = 32/300 (10%)
Query: 331 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQ 390
Q ER +Q+R E+ LR R++++ R +++L +Q Q++ +Q
Sbjct: 368 QEEERREQQLRREQQLR----REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 423
Query: 391 --RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 448
RRE+EE ++ EQ RR E+R +R +EER +R+ + ER E+ RR
Sbjct: 424 QLRREQEEERHEQKHEQERR-------EQRLKREQEERRDWLKREEETERHEQERR---- 472
Query: 449 RQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRE--RAEQIRRERAQRAARAKQ 506
+Q L R + ER R +L + ++ + ++RE+ L+ +E R ++++R+ + + +
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL 532
Query: 507 RQEGQLQREKREL-SRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAI 565
R E QL+RE+ E + + E L+ R+QR +RE +E + L
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE------------QEERRDQLLK 580
Query: 566 GRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 625
+ R ++L RE+ LE +E+ RE+ R R QL S +++
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640
Score = 81.6 bits (200), Expect = 2e-15
Identities = 80/302 (26%), Positives = 142/302 (47%), Gaps = 39/302 (12%)
Query: 338 RQVRAERGLRGV-PERDRKIAA---LMLARHQEELLLLEQ-RAAAHGQWELQRVHAKQR- 391
+Q+R + G + + ERDRK L+ R +++L E+ R + +L+R +Q+
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661
Query: 392 ---REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE----------- 437
R+R+ RE+++ L++G + E R R+ REE + RR++R+ +
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQE--RDRKFREEEQQLRRQERERKFLQEEQQLRRQ 1719
Query: 438 ------RSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 491
R EE+ R+ E++ L R+ER + E++LR ++EQ L+++E + E E
Sbjct: 1720 ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREE--E 1777
Query: 492 QIRRERAQRAARAKQ-----RQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLR 546
Q+R+ER ++ R+++ R+E QL++E+ E + R + Q +E+E
Sbjct: 1778 QLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQE--- 1834
Query: 547 SSLEASLGRAQENYEHLAIGRKLERSEQ-LTRERRSALESARSTARASFHVREKVREETN 605
L R E A K R EQ L +E R H+R + +EE
Sbjct: 1835 QRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894
Query: 606 TR 607
R
Sbjct: 1895 HR 1896
Score = 79.7 bits (195), Expect = 7e-15
Identities = 78/312 (25%), Positives = 139/312 (44%), Gaps = 30/312 (9%)
Query: 326 SPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQR 385
S Q QH+ ++ E+ R +RDR +E+L EQ+ A + Q
Sbjct: 1263 SQQDLQHLLGEQQERDREQERRRWQQRDRHFP------EEEQLEREEQKEAKRRDRKSQE 1316
Query: 386 VHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 445
R EREE+ +++ ++ R EE + + REE+ R+ + + R EE R +
Sbjct: 1317 EKQLLREEREEKRRRQETDRKFR------EEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370
Query: 446 LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRER-----AEQIRRERAQR 500
R+ L +R R RE + K +Q+ ++RE+ L++ R+R +Q+ R+ R
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430
Query: 501 AARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENY 560
R +++Q + +RE++ L ++ R E R R+ R+E + L+ E L R + +
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQE-----RHRKFREEEQLLQEREEQQLHRQERDR 1485
Query: 561 EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSF-------DRMV 613
+ L ++L R E+ + R L S + R +++ + R F R
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRS-QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544
Query: 614 REAQLHASLDRK 625
R Q DRK
Sbjct: 1545 RGQQRRQDRDRK 1556
Score = 77.8 bits (190), Expect = 3e-14
Identities = 83/325 (25%), Positives = 144/325 (44%), Gaps = 65/325 (20%)
Query: 349 VPERDRKIAALMLARHQEELLLLEQRAAAHGQW-ELQRVHAKQRREREERE------KQR 401
V R RK + QEE +R + QW E +R H +Q+ E + R+ +
Sbjct: 719 VYSRPRKQEGQRRRQEQEEK---RRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEE 775
Query: 402 ALEQGRRAWAAQ--VEERRGRRGREEREAARRRQR---QYERSEERRRELAERQGLLR-R 455
E+GR+ +A+ + E+R R+ R E E +R QR + E E+RRR+ ER+ L+
Sbjct: 776 KSERGRQRLSARPPLREQRERQLRAE-ERQQREQRFLPEEEEKEQRRRQRREREKELQFL 834
Query: 456 ERAERAAREDRLRKLQQEQN---------------------------------------- 475
E E+ R +R ++LQ+E++
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA 894
Query: 476 ----LKQREEGLQEGRERAEQIRRERAQRAARAKQ-RQEGQLQREKRELSRAERARHEAL 530
L++ ++ LQE E ++ RE+ +R + +Q R+E QLQ+E+ +L R ER +
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR- 953
Query: 531 LQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTA 590
Q R RQ R++++ L+ E LG E +K E+L +E L R
Sbjct: 954 -QERERQYRKDKK-LQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 591 RASFHVREKVREETNTRSFDRMVRE 615
R R+ +++ + ++++RE
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLRE 1036
Score = 77.8 bits (190), Expect = 3e-14
Identities = 82/326 (25%), Positives = 147/326 (45%), Gaps = 34/326 (10%)
Query: 322 DLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQW 381
D + Q + ER +++ A LR +R+R++ A EE EQR +
Sbjct: 766 DFTWQWQAEEKSERGRQRLSARPPLR--EQRERQLRA-------EERQQREQRFLPEEEE 816
Query: 382 ELQRVHAKQRREREER----EKQRALEQGRRAWAAQVEE------RRGRRGREEREAARR 431
+ QR +QRRERE+ E++ L++ RA Q EE + RR +E+R +
Sbjct: 817 KEQR--RRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874
Query: 432 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 491
R + E + RR L + L + R E+ ++ +LQ+E+ K+R + + E
Sbjct: 875 RWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE 934
Query: 492 QIRRE-----RAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ----ER 542
Q+++E R +R R +Q +E Q +++K+ + E+ E + R RQ+R+ E
Sbjct: 935 QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE-PEKRRRQEREKKYREE 993
Query: 543 EGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 602
E L+ E L +E R+ + ++L +E L R R R+ E
Sbjct: 994 EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE 1053
Query: 603 ETNTRSFDRMV---REAQLHASLDRK 625
E + ++++ RE + L+R+
Sbjct: 1054 EELQQEEEQLLGEERETRRRQELERQ 1079
Score = 77.4 bits (189), Expect = 4e-14
Identities = 76/262 (29%), Positives = 121/262 (46%), Gaps = 23/262 (8%)
Query: 372 EQRAAAHGQWEL--QRVHAKQRREREEREKQRALEQG-RRAWAAQVEERRGRRGREEREA 428
E+RA G+ L R + +R E R++Q E G RR Q +ER G E+ E
Sbjct: 98 EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE- 156
Query: 429 ARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLR--------KLQQEQNLKQRE 480
+++R +R +RR E RQ +ER ER A E++L+ + E+ L++RE
Sbjct: 157 --KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 481 --EGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 538
E ++GRE +Q RRER R + ++ +E R++ + R E + + R R+
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKE---WRKRETVLRKEEEKLQEEEPQRQREL 271
Query: 539 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 598
++E E LR L R ++ E ++L R +QL R++ + R RE
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQ--QRLRREQQLRRKQEEERREQQEERREQQERRE 329
Query: 599 --KVREETNTRSFDRMVREAQL 618
+ R E R RE QL
Sbjct: 330 QQEERREQQLRREQEERREQQL 351
Score = 77.0 bits (188), Expect = 5e-14
Identities = 77/265 (29%), Positives = 123/265 (46%), Gaps = 25/265 (9%)
Query: 323 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 382
L +T +H Q R ++ L+ E +R+ L L + + + E
Sbjct: 458 LKREEETERH-----EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE 512
Query: 383 LQRVHAKQRREREEREKQR--ALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSE 440
+R +R+E EER +QR + +Q RR + E+ R + E RR QR E
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE 572
Query: 441 ERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQR 500
ERR +L +R+ R++R +R +E+RL EQ LK+ E E ER EQ R +R
Sbjct: 573 ERRDQLLKREEERRQQRLKR-EQEERL-----EQRLKREEVERLEQEERREQ----RLKR 622
Query: 501 AARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENY 560
++R++ L+ E++E R ++ R E Q R+QR +RE LE L R
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRRE---QQERREQRLKREEEEERLEQRLKR----- 674
Query: 561 EHLAIGRKLERSEQLTRERRSALES 585
EH R+ E +E+ + R ++S
Sbjct: 675 EHEEERREQELAEEEQEQARERIKS 699
Score = 75.5 bits (184), Expect = 1e-13
Identities = 90/344 (26%), Positives = 147/344 (42%), Gaps = 61/344 (17%)
Query: 331 QHVERIVRQVRAERGL-RGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAK 389
+ VER+ ++ R E+ L R PE +R+ L+ + QEE + R + E QR+ +
Sbjct: 605 EEVERLEQEERREQRLKREEPEEERR-QQLLKSEEQEERRQQQLRREQQERRE-QRLKRE 662
Query: 390 QRREREEREKQRALEQGRRAWAAQVEERRGRRGRE-----------EREAARRRQRQYER 438
+ ER E+ +R E+ RR EE+ R R E EA R+ + Y R
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR 722
Query: 439 ---SEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLK-------QREEGLQEGRE 488
E +RR + + RRE + E+R + QQE+ + Q EE + GR+
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782
Query: 489 R--AEQIRRERAQRAARAKQRQEGQL-------QREKRELSRAERARH------EALLQG 533
R A RE+ +R RA++RQ+ + ++E+R R ER + E LQ
Sbjct: 783 RLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR 842
Query: 534 RTRQQR--QEREGLRSSLEASLGRAQEN-------------------YEHLAIGRKLERS 572
R R Q+ +E +GL+ E + Q Y A+ +L +
Sbjct: 843 RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE 902
Query: 573 EQLTRERRSALE-SARSTARASFHVREKVREETNTRSFDRMVRE 615
+QL +E L+ R R R+ EE + ++++RE
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE 946
Score = 74.7 bits (182), Expect = 2e-13
Identities = 86/313 (27%), Positives = 137/313 (43%), Gaps = 33/313 (10%)
Query: 334 ERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQW---------ELQ 384
ER +Q R E+ LR E R+ + QEE L+QR + Q +L
Sbjct: 495 ERREQQERREQQLRREQEERRE----QRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Query: 385 RVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRR 444
+ ++R E+E RE++ EQ R E R+ R +RE R +++ +R E R
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610
Query: 445 ELAE-RQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAAR 503
E E R+ L+RE E R+ L+ +QE+ +++++ +E +ER EQ R +R + R
Sbjct: 611 EQEERREQRLKREEPEEERRQQLLKSEEQEE--RRQQQLRREQQERREQ-RLKREEEEER 667
Query: 504 AKQRQEGQLQREKRELSRAERARHEALLQGRTR-----QQRQEREGLRSSLEASLGRAQE 558
+QR + + + E+RE AE + +A + ++R Q + R S S R QE
Sbjct: 668 LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727
Query: 559 ----NYEHLAIGRKLERSEQLTRERRSALESARSTARASF-------HVREKVREETNTR 607
E R+ E Q E R+ + R F E+ R+ + R
Sbjct: 728 GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR 787
Query: 608 SFDRMVREAQLHA 620
R RE QL A
Sbjct: 788 PPLREQRERQLRA 800
Score = 70.9 bits (172), Expect = 3e-12
Identities = 91/346 (26%), Positives = 153/346 (44%), Gaps = 64/346 (18%)
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQ---RAAAHGQW--- 381
+ Q E+++R+ +R + + + R+ L + +E+LL EQ R Q+
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQ--QEEEQLLREEQEKRRQERERQYREE 1202
Query: 382 -ELQRVHAKQR-REREER---------EKQRAL------------EQGRRAWAAQVEERR 418
ELQR KQR R+ ++R EK+ A+ EQ R+ +Q+ +R+
Sbjct: 1203 EELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ 1262
Query: 419 ---------GRRGREEREAARRR----------QRQYERSEE-----RRRELAERQGLLR 454
G + +RE RRR + Q ER E+ R R+ E + LLR
Sbjct: 1263 SQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLR 1322
Query: 455 RERAERAAREDRLRKL-QQEQNLKQREEGLQEGRERAEQIRRE--RAQRAARAKQRQEGQ 511
ER E+ R++ RK ++EQ L++REE +ER + R E R Q R +E +
Sbjct: 1323 EEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQR 1382
Query: 512 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 571
L+R++RE + + + Q R +Q RQ+R+ E L R + + + +++ R
Sbjct: 1383 LRRQERE-RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441
Query: 572 SEQLTRERRSALE--SARSTARASFHVREKVREETNTRSFDRMVRE 615
E RER+ E R F E++ +E + R R+
Sbjct: 1442 QE---RERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERD 1484
Score = 69.3 bits (168), Expect = 1e-11
Identities = 78/266 (29%), Positives = 123/266 (46%), Gaps = 30/266 (11%)
Query: 323 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA--LMLARHQEELLLLEQRAAAHGQ 380
L H E + Q E+ LR ERDRK L R + E L++ Q
Sbjct: 1661 LRHDRDRKFREEEQLLQEGEEQQLRR-QERDRKFREEEQQLRRQERERKFLQEEQQLRRQ 1719
Query: 381 WELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSE 440
EL+R ++ + R+E E+++ Q R + +EE + R REE++ R+ + + R E
Sbjct: 1720 -ELERKFREEEQLRQETEQEQLRRQER--YRKILEEEQLRPEREEQQLRRQERDRKFREE 1776
Query: 441 ERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQR---------EEGLQ----EGR 487
E+ R+ E Q L +E + E++LR+ ++EQ L+ + EE LQ E R
Sbjct: 1777 EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQR 1836
Query: 488 ---ERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREG 544
ER Q R E +R+E +L +E+ + R ER R L + R+Q++E +
Sbjct: 1837 LRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERER--KLREEHIRRQQKEEQR 1894
Query: 545 LRSSLEASLGRAQENYEHLAIGRKLE 570
R E ++QE H GR LE
Sbjct: 1895 HRQVGEI---KSQEGKGH---GRLLE 1914
Score = 61.2 bits (147), Expect = 3e-09
Identities = 67/245 (27%), Positives = 100/245 (40%), Gaps = 40/245 (16%)
Query: 415 EERRGR-RGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAR---------- 463
EE+R R G+E RR++ R E R R+L E G RR++ + R
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 464 -----EDRLRKLQQEQNLKQREEGLQEGRERAEQIR------------------RERAQR 500
E R R+ + E+ +QR+E + RAE+ + R R
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELL 216
Query: 501 AARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENY 560
R K R+E Q QR +R+ R + E + R R+E E L+ QE
Sbjct: 217 ELRRKGREEKQQQRRERQ-DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275
Query: 561 EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHA 620
E L RKLER E L RER+ E + R +R K EE + +R ++ +
Sbjct: 276 EQL---RKLERQE-LRRERQEE-EQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330
Query: 621 SLDRK 625
+R+
Sbjct: 331 QEERR 335
Score = 49.7 bits (117), Expect = 8e-06
Identities = 50/190 (26%), Positives = 84/190 (44%), Gaps = 17/190 (8%)
Query: 446 LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 505
L + GL +RA +E L+ +QE++ ++ E ++ E Q RR++ Q R
Sbjct: 89 LGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQEREL 148
Query: 506 QRQEGQLQREKRELSRAERARHEALLQGRTR-QQRQEREGLRSSLEASLGRAQENY---- 560
E Q ++++R R + R E L + R Q+R+ER L++ G E +
Sbjct: 149 AEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEE 208
Query: 561 -----EHLAIGRK-LERSEQLTRERRSAL---ESARSTARASFHVR---EKVREETNTRS 608
E L + RK E +Q RER+ + E + + +R EK++EE R
Sbjct: 209 QLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268
Query: 609 FDRMVREAQL 618
+ E QL
Sbjct: 269 RELQEEEEQL 278
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 95.9 bits (237), Expect = 1e-19
Identities = 100/364 (27%), Positives = 156/364 (42%), Gaps = 54/364 (14%)
Query: 157 ERRAKLQQCRAERDRIMREE--KRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASL--- 211
E++ K ++ E+ + RE K+R P SP A +A+ AS S S + SS S
Sbjct: 416 EKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWH 475
Query: 212 -PASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSY 270
PASP P SP T PP S G + S RR+E A S S A
Sbjct: 476 RPASPCP--------SPGPGHTLPPKPPSPRGTTA-SPKGRVRRKEEAKESPSAAGPEDK 526
Query: 271 SGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTA 330
S R A+ + P+ + S T P + P L+ P A
Sbjct: 527 SQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPT-----DAAVLTSPPAPA 581
Query: 331 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQ 390
V + + G +R+ L R Q A++
Sbjct: 582 P-------PVTPSKPMAGTTDREEATRLLAEKRRQ----------------------ARE 612
Query: 391 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 450
+REREE+E++ E+ +R Q+ R R EREA RR+ + E E+ + E E++
Sbjct: 613 QREREEQERRLQAERDKRMREEQL--AREAEARAEREAEARRREEQEAREKAQAEQEEQE 670
Query: 451 GLLR-RERAERAAREDRLR-KLQQEQNLKQREEGLQEGRERAEQI-RRERAQRAARAKQR 507
L + +E AE +RE+ R +L++E++ +Q+E+ QE R+R E+I +R R + KQ+
Sbjct: 671 RLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQK 730
Query: 508 QEGQ 511
Q+ +
Sbjct: 731 QDSK 734
Score = 72.4 bits (176), Expect = 1e-12
Identities = 101/388 (26%), Positives = 158/388 (40%), Gaps = 43/388 (11%)
Query: 182 TPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRT 241
+PL+P + + AP AG + SPAP R+ SP + +
Sbjct: 368 SPLTPCSVTRSVHRCAP-AGERGERRKPNAGGSPAP-VRRRPEASPVQKKEKKDKERENE 425
Query: 242 GRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNA 301
KS S ++ +L + A S+ + L P++ AR S P S++ +
Sbjct: 426 KEKSALARERSLKKRQSLPASPRARLSASTASELS-----PKSKARPSSP----STSWHR 476
Query: 302 PGRPSALTLVPITGRSFSLGDLSHSPQ--TAQHVERIVRQVRAERGLRGVPERDRKIAAL 359
P P P G +L SP+ TA R+ R+ A+ D K +
Sbjct: 477 PASPC-----PSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPED-KSQSK 530
Query: 360 MLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRG 419
A +++E A + K++ E A+ A A V +
Sbjct: 531 RRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAET-PTDAAVLTSPPAPAPPVTPSKP 589
Query: 420 RRGREEREAA--------RRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQ 471
G +RE A R+ + Q ER E+ RR AER +R R E+ ARE R +
Sbjct: 590 MAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERD---KRMREEQLAREAEARA-E 645
Query: 472 QEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALL 531
+E ++REE QE RE+A Q +E +R + K+ E + RE+ E R ER +H
Sbjct: 646 REAEARRREE--QEAREKA-QAEQEEQERLQKQKEEAEAR-SREEAERQRLEREKH---- 697
Query: 532 QGRTRQQRQEREGLRSSLEASLGRAQEN 559
+QQ QER+ R LE + R +++
Sbjct: 698 ---FQQQEQERQERRKRLEEIMKRTRKS 722
Score = 43.1 bits (100), Expect = 8e-04
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 6/97 (6%)
Query: 423 REEREAARRRQRQYERSEERRRELAERQGL-LRRERAERAAREDRLRKLQQEQNLKQREE 481
+E ++A R + ER EER + LA ++ + L +E +A RE +L QE+ + E+
Sbjct: 130 QEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQL----QERRRRLEEQ 185
Query: 482 GLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRE 518
L+ + RA R+R Q+ + K+R E +QR ++
Sbjct: 186 RLKAEQRRAALEERQR-QKLEKNKERYEAAIQRSVKK 221
Score = 40.8 bits (94), Expect = 0.004
Identities = 34/121 (28%), Positives = 59/121 (48%), Gaps = 15/121 (12%)
Query: 439 SEERRRELAERQGLLRRERAERA---AREDRLRKLQQEQNLKQREEGLQEGRERAEQIRR 495
+++ ++ ER L + R ERA A + + ++E+ RE+ LQE R R E+ R
Sbjct: 128 TKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187
Query: 496 ERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ----RQEREGLRSSLEA 551
+ QR A ++RQ +L++ K R+EA +Q ++ RQ+R +L
Sbjct: 188 KAEQRRAALEERQRQKLEKNKE--------RYEAAIQRSVKKTWAEIRQQRWSWAGALHH 239
Query: 552 S 552
S
Sbjct: 240 S 240
Score = 38.5 bits (88), Expect = 0.019
Identities = 23/74 (31%), Positives = 37/74 (50%), Gaps = 2/74 (2%)
Query: 387 HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRREL 446
H + REER K A ++ W + E+ + R ++ +E RR + Q ++E+RR L
Sbjct: 139 HKLAKERREERAKYLAAKKA--VWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAAL 196
Query: 447 AERQGLLRRERAER 460
ERQ + ER
Sbjct: 197 EERQRQKLEKNKER 210
Score = 35.0 bits (79), Expect = 0.21
Identities = 53/230 (23%), Positives = 89/230 (38%), Gaps = 23/230 (10%)
Query: 209 ASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSS 268
A P + R + PSP + PPP S + D+ + S +
Sbjct: 11 AGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPP-DTPPAMKNATSSKQLPLEPE 69
Query: 269 SYSGESLRELRWPPRASARNSCPAGSASSTTNAP-------GRPSALTLVPITGRSFSLG 321
S SG+ P A + P+ A S P RP + P S +
Sbjct: 70 SPSGQV-----GPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQP----SPTAV 120
Query: 322 DLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA---LMLARHQEELLLLE-QRAAA 377
S SP T Q V++ + + + R ER + +AA + L + ++ L E Q
Sbjct: 121 PASDSPPTKQEVKKAGERHKLAKERR--EERAKYLAAKKAVWLEKEEKAKALREKQLQER 178
Query: 378 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREERE 427
+ E QR+ A+QRR E +++ LE+ + + A ++ + E R+
Sbjct: 179 RRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQ 228
Score = 33.1 bits (74), Expect = 0.79
Identities = 65/272 (23%), Positives = 98/272 (36%), Gaps = 39/272 (14%)
Query: 39 EAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDC 98
E+ ++ P+ + + AS+ SA+ A P + P ++EQ P
Sbjct: 516 ESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPA---------- 565
Query: 99 PEAEGSRYVLTSPRSLEACARCAVKPV------ELLPRALADLVREAPGRSMRVATGLYE 152
E VLTSP + A KP+ E R LA+ R+A R R E
Sbjct: 566 -ETPTDAAVLTSPPA-PAPPVTPSKPMAGTTDREEATRLLAEKRRQA--REQR------E 615
Query: 153 AYEAERRAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLP 212
E ERR + AERD+ MREE+ A A A A A + A
Sbjct: 616 REEQERRLQ-----AERDKRMREEQL-----AREAEARAEREAEARRREEQEAREKAQAE 665
Query: 213 ASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSG 272
R ++ + AR++ R R+ H R+E E + S
Sbjct: 666 QEEQERLQKQ--KEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSE 723
Query: 273 ES-LRELRWPPRASARNSCPAGSASSTTNAPG 303
S ++ + A+A S P + +PG
Sbjct: 724 VSETKQKQDSKEANANGSSPEPVKAVEARSPG 755
Score = 30.4 bits (67), Expect = 5.1
Identities = 32/112 (28%), Positives = 55/112 (49%), Gaps = 12/112 (10%)
Query: 399 KQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERA 458
KQ + G R A+ ERR R + ++ + EE+ + L E+Q RR R
Sbjct: 129 KQEVKKAGERHKLAK--ERREERAKY----LAAKKAVWLEKEEKAKALREKQLQERRRRL 182
Query: 459 ERAAREDRLRKLQQEQNLKQRE-EGLQEGRERAE-QIRRERAQRAARAKQRQ 508
E E RL+ Q+ L++R+ + L++ +ER E I+R + A +Q++
Sbjct: 183 E----EQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 90.5 bits (223), Expect = 4e-18
Identities = 68/211 (32%), Positives = 120/211 (56%), Gaps = 26/211 (12%)
Query: 379 GQWELQRVHAKQRRERE----EREKQRALEQGRRAWAAQVEERRGRRGREEREAA-RRRQ 433
G+ E + K+RRERE EREK+R E+G++ E++G R +EERE RRR+
Sbjct: 51 GKKERESERKKERREREKRKREREKERKRERGKK-------EKKGERKKEERERKKRRRE 103
Query: 434 RQY---ERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERA 490
++ E E+R+++ + +G +E ER +E+R R+ ++E+ K+ E ++ RER
Sbjct: 104 KENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER--EKERERK 161
Query: 491 EQIRRERAQRAARAKQRQEGQ-LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSL 549
E+ +RER Q + ++R+E + +R+KRE +R ER + R R++R+ER+ R
Sbjct: 162 ERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKE------RERKERRERKKERKKK 215
Query: 550 EASLGRAQENYEHLAIGRKLERSEQLTRERR 580
E Q++ + R+ ER ++ +ER+
Sbjct: 216 EERKKERQKDRQ--TNWREKERGKRERKERK 244
Score = 78.2 bits (191), Expect = 2e-14
Identities = 57/210 (27%), Positives = 112/210 (53%), Gaps = 10/210 (4%)
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 397
R+ E G ER+ + R + + ++R G+ E + K+ RER++R
Sbjct: 41 REREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKR 100
Query: 398 EKQRALEQGRRAWAAQVEER--RGRRGREEREAARRRQRQYERSEERRRELAERQGLLRR 455
+++ ++G + +E+ RGR +E +E R+ +R+ E +ER R+ ER+ R
Sbjct: 101 RREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREK--ER 158
Query: 456 ERAERAAREDR-LRKLQQEQNLKQREEGLQEGRERAEQIR-RERAQRAARAKQRQEGQLQ 513
ER ER RE + + + ++E+ K+R+E + R R E+ + RER +R R K+R++ + +
Sbjct: 159 ERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEER 218
Query: 514 REKRELSRAERARHEALLQGRTRQQRQERE 543
+++R+ R R + R +++R+ER+
Sbjct: 219 KKERQKDRQTNWREKE----RGKRERKERK 244
Score = 77.4 bits (189), Expect = 4e-14
Identities = 68/259 (26%), Positives = 125/259 (48%), Gaps = 38/259 (14%)
Query: 371 LEQRAAAHGQWELQRVHAKQRR--------EREEREKQRALEQGRRAWAAQVEERRG-RR 421
+ RAA ELQ V + E RE++R +E + + ER+ RR
Sbjct: 5 ISSRAAVKLNTELQMVSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERR 64
Query: 422 GREEREAARRRQRQYERSE-----ERRRELAERQGLLRRERAERAAREDRLRKLQQEQNL 476
RE+R+ R ++R+ ER + ER++E ER ++ R E+ +E ++ ++++
Sbjct: 65 EREKRKREREKERKRERGKKEKKGERKKEERER----KKRRREKENKEGEEKEKRKKKEK 120
Query: 477 KQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTR 536
K+R +EG+ER + R+R +R R ++++E + +RE++E + ER + + R
Sbjct: 121 KERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKE 180
Query: 537 QQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHV 596
++R+ER+ + + N + RK ER + RER+ + +
Sbjct: 181 KERKERK-----------KRERNRKE----RKKERERKERRERKKERKKKEERKKE---- 221
Query: 597 REKVREETNTRSFDRMVRE 615
R+K R +TN R +R RE
Sbjct: 222 RQKDR-QTNWREKERGKRE 239
Score = 72.8 bits (177), Expect = 9e-13
Identities = 43/141 (30%), Positives = 81/141 (57%), Gaps = 5/141 (3%)
Query: 389 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERR-RELA 447
K+ E+E+R+K+ E+GR + + ER+ R REER+ R++ + E+ ER+ R+
Sbjct: 107 KEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKR 166
Query: 448 ERQ--GLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 505
ER+ G ER E+ +E + R+ +++ K+RE +E RER ++ +++ ++ R K
Sbjct: 167 ERKQVGEKEEERKEKERKERKKRERNRKERKKERER--KERRERKKERKKKEERKKERQK 224
Query: 506 QRQEGQLQREKRELSRAERAR 526
RQ ++E+ + R ER +
Sbjct: 225 DRQTNWREKERGKRERKERKK 245
Score = 39.3 bits (90), Expect = 0.011
Identities = 30/141 (21%), Positives = 60/141 (42%), Gaps = 8/141 (5%)
Query: 485 EGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREG 544
E RER +I + + R +R++ + +REKR+ R + + E + ++E++G
Sbjct: 37 EIREREREIETRKEGKKERESERKKERREREKRKREREKERKRE--------RGKKEKKG 88
Query: 545 LRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREET 604
R E + + E+ K +R ++ +ER + + R RE+ +E
Sbjct: 89 ERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERE 148
Query: 605 NTRSFDRMVREAQLHASLDRK 625
+ RE + +RK
Sbjct: 149 RKKEEREKERERKERKKRERK 169
Score = 30.4 bits (67), Expect = 5.1
Identities = 29/138 (21%), Positives = 56/138 (40%), Gaps = 19/138 (13%)
Query: 315 GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQR 374
GR+ G + + ER R+ + E + ++RK +EE ++R
Sbjct: 124 GRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKER 183
Query: 375 AAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQR 434
+ ++ K+R +E RE+ ++ R+ +EER+ R++ R
Sbjct: 184 KERKKRERNRKERKKERERKERRER-----------------KKERKKKEERKKERQKDR 226
Query: 435 Q--YERSEERRRELAERQ 450
Q + E +RE ER+
Sbjct: 227 QTNWREKERGKRERKERK 244
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 88.6 bits (218), Expect = 2e-17
Identities = 70/274 (25%), Positives = 123/274 (44%), Gaps = 10/274 (3%)
Query: 331 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQ 390
+H ER R+ ER ER R+ R ++ E+ A + +R +
Sbjct: 204 RHSER-GRERERERETETETERKRQTDR---ERDRQRKTEREREKQAERERASERETERD 259
Query: 391 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 450
+ ER++ R ++ ++ Q + +R RR +RE R+R+RQ ER ER R +
Sbjct: 260 KERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRER 319
Query: 451 GLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEG 510
R ER +R R+ ++E+ K++ E RER Q RE ++A R ++R+
Sbjct: 320 ERERERERERQRETERDREKERERKRKRQTE---MDRERNRQTGREGRRQAERERERERE 376
Query: 511 QLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSS---LEASLGRAQENYEHLAIGR 567
+ ++ RE ER R + R RQ ++R+G R + E R E R
Sbjct: 377 RDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGRER 436
Query: 568 KLERSEQLTRERRSALESARSTARASFHVREKVR 601
+ ++ + RER++ ++ R R++ +V R
Sbjct: 437 EKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPR 470
Score = 87.4 bits (215), Expect = 4e-17
Identities = 72/264 (27%), Positives = 118/264 (44%), Gaps = 35/264 (13%)
Query: 378 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQY 436
H + + R ++R+ ER++QR E+ R+ + ER G RGR+ + + R R+RQ
Sbjct: 94 HRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQR 153
Query: 437 ERSEERRREL-AERQGLLRRERAE-------RAAREDRLRKLQQEQNLKQR--EEGLQEG 486
+ +ER R+ ERQ R R + R R +R R+ ++E + R E G +
Sbjct: 154 DAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERE 213
Query: 487 RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLR 546
RER + ER ++ R + RQ + +RE+ + + ERA + + R++ ++R+ R
Sbjct: 214 RERETETETERKRQTDRERDRQR-KTEREREKQAERERASERETERDKERERERDRDRDR 272
Query: 547 SSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNT 606
R+ ER Q R+R+ E R T R RE+ RE
Sbjct: 273 DR------------------RQKERERQTDRKRQRRTERDRETERKRERQRERERERERN 314
Query: 607 RSFDR-----MVREAQLHASLDRK 625
R +R RE Q DR+
Sbjct: 315 RKRERERERERERERQRETERDRE 338
Score = 86.3 bits (212), Expect = 8e-17
Identities = 64/246 (26%), Positives = 116/246 (47%), Gaps = 22/246 (8%)
Query: 389 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 448
++R ++ERE++R Q R + + +R RR ++R R R R+ +R E+ RE
Sbjct: 54 RERNRQKERERRREKRQTER----ETDRKRERRREKDRHRKRDRHRERQRDREKERERQT 109
Query: 449 RQGLLRRERAERAAREDRLRKLQQE-QNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
+ R+ ER +++R R+ ++E + + R+ Q RER +ER ++ R +QR
Sbjct: 110 DRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQR 169
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHL---- 563
Q + ++++RE + + R E R++++E+E + GR +E
Sbjct: 170 QTERNRQKEREREKNRQERRE-------RERQREKENKTEDRHSERGRERERERETETET 222
Query: 564 ----AIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLH 619
R+ +R + RER E R++ R + R+K RE R DR R+ +
Sbjct: 223 ERKRQTDRERDRQRKTEREREKQAERERASERET--ERDKERERERDRDRDRDRRQKERE 280
Query: 620 ASLDRK 625
DRK
Sbjct: 281 RQTDRK 286
Score = 84.0 bits (206), Expect = 4e-16
Identities = 81/307 (26%), Positives = 134/307 (43%), Gaps = 26/307 (8%)
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 397
R+ +R R +R RK RH+E E+ E R K+R ++ER
Sbjct: 73 RETDRKRERRREKDRHRK-----RDRHRERQRDREKERERQTDRERDRQREKERNRQKER 127
Query: 398 EKQ--RALEQGRRAWAAQVEERRGRRGRE---EREAARRRQRQYERSEERRRELAE-RQG 451
E++ R E+GR ER +R E ER+ R RQRQ ER+ ++ RE + RQ
Sbjct: 128 ERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQE 187
Query: 452 LLRRER------------AERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQ 499
RER +ER +R R+ + E K++ + ++ + + E+ R ++A+
Sbjct: 188 RRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAE 247
Query: 500 RAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQEN 559
R +++ E +RE+ +R R + + +T ++RQ R E R +E
Sbjct: 248 RERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRER 307
Query: 560 YEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMV-REAQL 618
RK ER + RER E+ R R R++ R+ R +R RE +
Sbjct: 308 ERERERNRKRERERERERERERQRETERD--REKERERKRKRQTEMDRERNRQTGREGRR 365
Query: 619 HASLDRK 625
A +R+
Sbjct: 366 QAERERE 372
Score = 83.6 bits (205), Expect = 5e-16
Identities = 79/297 (26%), Positives = 124/297 (41%), Gaps = 25/297 (8%)
Query: 343 ERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRA 402
+R G ER+R+ A + +E E++ + +R K R+ER ERE+QR
Sbjct: 140 DRQTDGQRERERQRDA---EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQRE 196
Query: 403 LEQGRRAWAAQVEERRGRRGRE-------EREAARRRQ----RQYERSEERRRE-LAERQ 450
E + E+R RGRE E E R+RQ R +R ER RE AER+
Sbjct: 197 KEN-------KTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERE 249
Query: 451 GLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEG 510
RE ER +R R ++++ +Q+E Q R+R + R+R R +QR+
Sbjct: 250 RASERE-TERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERE 308
Query: 511 QLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLE 570
+ + R+ R E Q T + R++ + + + R + R+ E
Sbjct: 309 RERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAE 368
Query: 571 RSEQLTRER-RSALESARSTARASFHVREKVREETNTRSFD-RMVREAQLHASLDRK 625
R + RER R + R R+K RE + D + E Q DR+
Sbjct: 369 RERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRE 425
Score = 80.9 bits (198), Expect = 3e-15
Identities = 82/293 (27%), Positives = 125/293 (42%), Gaps = 22/293 (7%)
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 397
RQ R ER ER R+ RH E E+ + E +R ++R + +
Sbjct: 185 RQERRER------ERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKT 238
Query: 398 EKQRALEQGRRAWAAQVEERRGRRGREEREAARRR-QRQYERSEERRRELAERQGLLRRE 456
E++R +Q R A++ E R + ER+ R R +RQ ER + R +RQ R+
Sbjct: 239 ERERE-KQAERERASERETERDKERERERDRDRDRDRRQKERERQTDR---KRQRRTERD 294
Query: 457 R-AERAAREDRLRKLQQEQNLK-QREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQR 514
R ER R R+ ++E+N K +RE + RER + R+R + R ++RQ +
Sbjct: 295 RETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRE 354
Query: 515 EKRELSR-----AERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKL 569
R+ R AER R + R RQ +ERE + R +E R
Sbjct: 355 RNRQTGREGRRQAERERERE--RERDRQSARERE--ERERDRDRDRQKERERQTEKDRDG 410
Query: 570 ERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASL 622
+R + RER ES R R ++K RE R DR + ++L
Sbjct: 411 QRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTL 463
Score = 53.9 bits (128), Expect = 4e-07
Identities = 43/177 (24%), Positives = 82/177 (46%), Gaps = 8/177 (4%)
Query: 436 YERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRR 495
+ R +E R+GL + + +R R+ ++E+ ++R+ + R+R + +
Sbjct: 26 FSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREK 85
Query: 496 ERAQRAARAKQRQEGQLQREKRELSR-AERARHEALLQGRTRQQRQEREGLRSSLEASLG 554
+R ++ R ++RQ + + +R+ R +R R + + + R++ EREG R + G
Sbjct: 86 DRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDG 145
Query: 555 RAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDR 611
+ + + A + ER Q RER+ E R R REK R+E R R
Sbjct: 146 QRERERQRDA---EKERERQTDRERQRQTERNRQKERE----REKNRQERRERERQR 195
Score = 47.0 bits (110), Expect = 5e-05
Identities = 52/175 (29%), Positives = 77/175 (44%), Gaps = 11/175 (6%)
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQR-REREE 396
RQ ER ER RK M R + E R A + E +R +Q REREE
Sbjct: 329 RQRETERDREKERERKRKRQTEM-DRERNRQTGREGRRQAERERERERERDRQSAREREE 387
Query: 397 REKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRRELA-ERQGLLR 454
RE+ R ++ + ER+ + R+ +RE ++R+R+ +R ER RE ER+
Sbjct: 388 RERDRDRDRQKE------RERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKG 441
Query: 455 RERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQE 509
RER +R + DR Q++++ + R Q R R R K E
Sbjct: 442 RER-DRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPE 495
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 88.2 bits (217), Expect = 2e-17
Identities = 124/512 (24%), Positives = 212/512 (41%), Gaps = 62/512 (12%)
Query: 104 SRYVLTSPRSLEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQ 163
S VL SL A V+ R LA E P S R+ Y ER ++
Sbjct: 314 SPQVLAQKYSLVAKQESVVRRAS---RRLAKKTAEEPAASGRIICHSY----LERLLNVE 366
Query: 164 QCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKA 223
+ ++ E+K P A AAA P ++S P + A
Sbjct: 367 VPQ----KVGSEQKE----PPEEAEPVAAAEPEVPENNGNNSW-----PHNDTEIANSTP 413
Query: 224 SPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLR---ELRW 280
+P P+++ + P AG + K+ D + A S + S E E
Sbjct: 414 NPKPAASSPETPSAGQQEA-KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQ 472
Query: 281 PPRASARNS-CPAGSASSTTNA---PGRPSALTLVPITG-----RSFSLGD----LSHSP 327
PPR+ +S CPA + + + + P + +SF + +
Sbjct: 473 PPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKE 532
Query: 328 QTAQHVERIVRQVRAERGLRGVPERD--RKIAALMLARHQEELLLLEQRAAAHGQWELQR 385
+ Q +E + R+ AE+ R E D R++ + L R + +L+ R E ++
Sbjct: 533 KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKK 592
Query: 386 VHAKQR------REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERS 439
+Q+ + + +E++ A E+ ++ AA+ E R ++E EA R R Q E
Sbjct: 593 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 652
Query: 440 EERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRE--RAEQIRRER 497
E R +EL +++ +ER +AA RL + Q+EQ +++E QE RE R EQ RRE+
Sbjct: 653 ERRHQELLQKKKEEEQERLRKAAEAKRLAE-QREQERREQERREQERREQERREQERREQ 711
Query: 498 AQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQ 557
++ A ++R+E + + +REL E+A R ++E L+ LE + +
Sbjct: 712 ERQLAEQERRREQERLQAERELQEREKA------------LRLQKEQLQRELEEK--KKK 757
Query: 558 ENYEHLAIGRKLERSEQLTRERRSALESARST 589
E + LA + E E+ +E A ++ T
Sbjct: 758 EEQQRLAERQLQEEQEKKAKEAAGASKALNVT 789
Score = 73.9 bits (180), Expect = 4e-13
Identities = 68/246 (27%), Positives = 121/246 (49%), Gaps = 29/246 (11%)
Query: 391 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 450
R + +E+E+QR R+ A Q+ RR + E + RR + + EER R++
Sbjct: 527 RMDPKEKERQRLENLRRKEEAEQL-----RRQKVEEDKRRRLEEVKLKREERLRKV---- 577
Query: 451 GLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEG 510
L RER E+ E +K Q EQ Q +E ++ +E E++ E+A++ A AK+ +E
Sbjct: 578 -LQARERVEQMKEE---KKKQIEQKFAQIDEKTEKAKE--ERLAEEKAKKKAAAKKMEEV 631
Query: 511 QLQREKRELSRA--------ERARHEALLQGRTRQQRQEREGLRSSLEAS-LGRAQENYE 561
+ +R++ E +R E RH+ LLQ +++ +E+E LR + EA L +E
Sbjct: 632 EARRKQEEEARRLRWLQQEEEERRHQELLQ---KKKEEEQERLRKAAEAKRLAEQREQER 688
Query: 562 HLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVR--EAQLH 619
R+ ER EQ RE+ + + + +E+++ E + ++ +R + QL
Sbjct: 689 REQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQ 748
Query: 620 ASLDRK 625
L+ K
Sbjct: 749 RELEEK 754
Score = 73.9 bits (180), Expect = 4e-13
Identities = 65/261 (24%), Positives = 121/261 (46%), Gaps = 47/261 (18%)
Query: 382 ELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARR-RQRQYERSE 440
E QR+ +R+E E+ +++ +E+ +R +V+ +R R R+ +A R Q + E+ +
Sbjct: 534 ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKK 593
Query: 441 ERRRELAERQGLLRRERAERAARED------------------------RLRKLQQEQNL 476
+ ++ A+ + + ER A E RLR LQQE+
Sbjct: 594 QIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE 653
Query: 477 KQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTR 536
++ +E LQ+ +E ++ R+ A+ A+QR++ + ++E+RE R E+ R E Q R
Sbjct: 654 RRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE---QERRE 710
Query: 537 QQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHV 596
Q+RQ E R + E L R+L+ E+ R ++ L+ +
Sbjct: 711 QERQLAEQER----------RREQERLQAERELQEREKALRLQKEQLQR---------EL 751
Query: 597 REKVREETNTRSFDRMVREAQ 617
EK ++E R +R ++E Q
Sbjct: 752 EEKKKKEEQQRLAERQLQEEQ 772
Score = 45.8 bits (107), Expect = 1e-04
Identities = 112/512 (21%), Positives = 176/512 (34%), Gaps = 109/512 (21%)
Query: 183 PLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPA-GSRT 241
PL + A+A+AP++ + S P R + S A Q P G T
Sbjct: 191 PLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQGVGT 250
Query: 242 GRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNA 301
GR + L A S S ++ RE P S P GS + + +
Sbjct: 251 GRSASKLRI-------AQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSV 303
Query: 302 PGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGL-RGVPERDRKIAALM 360
R S PI S S L+ E +VR RA R L + E ++
Sbjct: 304 --RHS-----PIAPSSPSPQVLAQKYSLVAKQESVVR--RASRRLAKKTAEEPAASGRII 354
Query: 361 LARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALE------QGRRAW---- 410
+ E LL +E Q+V ++Q+ EE E A E G +W
Sbjct: 355 CHSYLERLLNVEVP---------QKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHND 405
Query: 411 ---------------------AAQVEERRGRR-GREEREAARRRQRQYERSEERRRELAE 448
A Q E + + G E + RR+R Y+++ EL E
Sbjct: 406 TEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVS---ELDE 462
Query: 449 RQGLLRRER-------------AERAAREDR--LRKLQQEQ------------------- 474
Q L E A + R R L +Q+ Q
Sbjct: 463 EQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKR 522
Query: 475 NLKQREEGLQEGRERAEQIRR-ERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQG 533
N R + ++ R+R E +RR E A++ R K ++ + + E+ +L R ER R +
Sbjct: 523 NTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARE 582
Query: 534 RTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS 593
R Q ++E+ + Q + I K E++++ A + A +
Sbjct: 583 RVEQMKEEK------------KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEE 630
Query: 594 FHVREKVREETNTRSFDRMVREAQLHASLDRK 625
R K EE + + E + H L +K
Sbjct: 631 VEARRKQEEEARRLRWLQQEEEERRHQELLQK 662
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 86.7 bits (213), Expect = 6e-17
Identities = 125/516 (24%), Positives = 212/516 (41%), Gaps = 66/516 (12%)
Query: 104 SRYVLTSPRSLEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQ 163
S VL SL A V+ R LA E P S R+ Y ER ++
Sbjct: 314 SPQVLAQKYSLVAKQESVVRRAS---RRLAKKTAEEPAASGRIICHSY----LERLLNVE 366
Query: 164 QCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKA 223
+ ++ E+K P A AAA P ++S P + A
Sbjct: 367 VPQ----KVGSEQKE----PPEEAEPVAAAEPEVPENNGNNSW-----PHNDTEIANSTP 413
Query: 224 SPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLR---ELRW 280
+P P+++ + P AG + K+ D + A S + S E E
Sbjct: 414 NPKPAASSPETPSAGQQEA-KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQ 472
Query: 281 PPRASARNS-CPAGSASSTTNA---PGRPSALTLVPITG-----RSFSLGDL-------- 323
PPR+ +S CPA + + + + P + +SF +
Sbjct: 473 PPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKC 532
Query: 324 SHSPQTAQHVERIVRQVRAERGLRGVPERD--RKIAALMLARHQEELLLLEQRAAAHGQW 381
S + Q +E + R+ AE+ R E D R++ + L R + +L+ R
Sbjct: 533 SFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 592
Query: 382 ELQRVHAKQR------REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQ 435
E ++ +Q+ + + +E++ A E+ ++ AA+ E R ++E EA R R Q
Sbjct: 593 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652
Query: 436 YERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRE--RAEQI 493
E E R +EL +++ +ER +AA RL + Q+EQ +++E QE RE R EQ
Sbjct: 653 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAE-QREQERREQERREQERREQERREQE 711
Query: 494 RRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASL 553
RRE+ ++ A ++R+E + + +REL E+A R ++E L+ LE
Sbjct: 712 RREQERQLAEQERRREQERLQAERELQEREKA------------LRLQKEQLQRELEEK- 758
Query: 554 GRAQENYEHLAIGRKLERSEQLTRERRSALESARST 589
+ +E + LA + E E+ +E A ++ T
Sbjct: 759 -KKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVT 793
Score = 73.9 bits (180), Expect = 4e-13
Identities = 65/261 (24%), Positives = 121/261 (46%), Gaps = 47/261 (18%)
Query: 382 ELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARR-RQRQYERSE 440
E QR+ +R+E E+ +++ +E+ +R +V+ +R R R+ +A R Q + E+ +
Sbjct: 538 ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKK 597
Query: 441 ERRRELAERQGLLRRERAERAARED------------------------RLRKLQQEQNL 476
+ ++ A+ + + ER A E RLR LQQE+
Sbjct: 598 QIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE 657
Query: 477 KQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTR 536
++ +E LQ+ +E ++ R+ A+ A+QR++ + ++E+RE R E+ R E Q R
Sbjct: 658 RRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE---QERRE 714
Query: 537 QQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHV 596
Q+RQ E R + E L R+L+ E+ R ++ L+ +
Sbjct: 715 QERQLAEQER----------RREQERLQAERELQEREKALRLQKEQLQR---------EL 755
Query: 597 REKVREETNTRSFDRMVREAQ 617
EK ++E R +R ++E Q
Sbjct: 756 EEKKKKEEQQRLAERQLQEEQ 776
Score = 72.0 bits (175), Expect = 2e-12
Identities = 67/241 (27%), Positives = 118/241 (48%), Gaps = 29/241 (12%)
Query: 396 EREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRR 455
E+E+QR R+ A Q+ RR + E + RR + + EER R++ L R
Sbjct: 536 EKERQRLENLRRKEEAEQL-----RRQKVEEDKRRRLEEVKLKREERLRKV-----LQAR 585
Query: 456 ERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQRE 515
ER E+ E +K Q EQ Q +E ++ +E E++ E+A++ A AK+ +E + +R+
Sbjct: 586 ERVEQMKEE---KKKQIEQKFAQIDEKTEKAKE--ERLAEEKAKKKAAAKKMEEVEARRK 640
Query: 516 KRELSRA--------ERARHEALLQGRTRQQRQEREGLRSSLEAS-LGRAQENYEHLAIG 566
+ E +R E RH+ LLQ +++ +E+E LR + EA L +E
Sbjct: 641 QEEEARRLRWLQQEEEERRHQELLQ---KKKEEEQERLRKAAEAKRLAEQREQERREQER 697
Query: 567 RKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVR--EAQLHASLDR 624
R+ ER EQ RE+ + + + +E+++ E + ++ +R + QL L+
Sbjct: 698 REQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 757
Query: 625 K 625
K
Sbjct: 758 K 758
Score = 44.3 bits (103), Expect = 3e-04
Identities = 108/513 (21%), Positives = 175/513 (34%), Gaps = 107/513 (20%)
Query: 183 PLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPA-GSRT 241
PL + A+A+AP++ + S P R + S A Q P G T
Sbjct: 191 PLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQGVGT 250
Query: 242 GRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNA 301
GR + L A S S ++ RE P S P GS + + +
Sbjct: 251 GRSASKLRI-------AQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSV 303
Query: 302 PGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGL-RGVPERDRKIAALM 360
R S PI S S L+ E +VR RA R L + E ++
Sbjct: 304 --RHS-----PIAPSSPSPQVLAQKYSLVAKQESVVR--RASRRLAKKTAEEPAASGRII 354
Query: 361 LARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALE------QGRRAW---- 410
+ E LL +E Q+V ++Q+ EE E A E G +W
Sbjct: 355 CHSYLERLLNVEVP---------QKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHND 405
Query: 411 ---------------------AAQVEERRGRR-GREEREAARRRQRQYERS-----EERR 443
A Q E + + G E + RR+R Y+++ EE+
Sbjct: 406 TEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQH 465
Query: 444 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGL-------------------- 483
E E Q + + +R L+ + QR + L
Sbjct: 466 LEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTP 525
Query: 484 ----------QEGRERAEQIRR-ERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQ 532
++ R+R E +RR E A++ R K ++ + + E+ +L R ER R +
Sbjct: 526 LRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR 585
Query: 533 GRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARA 592
R Q ++E+ + Q + I K E++++ A + A +
Sbjct: 586 ERVEQMKEEK------------KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKME 633
Query: 593 SFHVREKVREETNTRSFDRMVREAQLHASLDRK 625
R K EE + + E + H L +K
Sbjct: 634 EVEARRKQEEEARRLRWLQQEEEERRHQELLQK 666
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 86.3 bits (212), Expect = 8e-17
Identities = 78/244 (31%), Positives = 119/244 (48%), Gaps = 31/244 (12%)
Query: 366 EELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRAL-EQGRRAWAAQVEERRGRRGRE 424
E+L LE+ AA + E + + +RE EER++Q L Q Q EE R RR E
Sbjct: 718 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 777
Query: 425 E-----REAARRRQRQYERSEERRRELAERQGL---------LRRERAERAAREDRLRKL 470
E +E A RRQR+ E + R+RE ERQ RRE ER +E+ LRK
Sbjct: 778 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 837
Query: 471 QQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQRE-----KRELSRAERA 525
++E REE +E + R E+ R + AAR + +E + ++E ++EL R +
Sbjct: 838 EEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 895
Query: 526 RHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-------HLAIGRKL--ERSEQLT 576
+ EAL + + +QQ+Q+ ++ ++ G+ LA +KL ER QL
Sbjct: 896 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 955
Query: 577 RERR 580
E+R
Sbjct: 956 EEQR 959
Score = 74.3 bits (181), Expect = 3e-13
Identities = 77/280 (27%), Positives = 127/280 (45%), Gaps = 20/280 (7%)
Query: 331 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQE-ELLLLEQRAAAHGQWELQRVHA- 388
Q E + RQ ER R E R+ L R +E E+ L QR Q + + +
Sbjct: 758 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 817
Query: 389 -KQRREREEREKQRAL----EQGRRAWAAQVEERRGR----RGREEREAARRRQRQYERS 439
++RRE EER KQ L E+ WA + EE + R R R E EAAR R +E
Sbjct: 818 EERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR---HEEE 874
Query: 440 EERRREL-AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERA 498
E +R+EL +RQ L R+R ++ RL++ QQ+Q L Q + L +Q
Sbjct: 875 ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK--LPSSSTWGQQSNTTAC 932
Query: 499 QRAARAKQRQEGQLQREK-RELSRAERARHEALLQGRTRQQRQEREGLR--SSLEASLGR 555
Q A + +L+ E+ R+L +R + L++ +QQ+Q+++ L ++ G
Sbjct: 933 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 992
Query: 556 AQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 595
+ E + + +Q +++ AR+ ++ H
Sbjct: 993 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1032
Score = 72.4 bits (176), Expect = 1e-12
Identities = 69/249 (27%), Positives = 120/249 (48%), Gaps = 25/249 (10%)
Query: 388 AKQRREREEREKQRALEQGR-----RAWAAQVEERRGRRGREEREAARRRQRQYERSEER 442
A ++ ++ E+ K LEQ R RA + E +R R ++E RRQ++ ER
Sbjct: 716 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 775
Query: 443 RRELAER--QGLLRRER----AERAAREDRLRKLQQE--QNLKQREEGLQEGRERAEQIR 494
ELA R + LRR+R A R RE+ R+ Q+E + L++R +E R++ E +R
Sbjct: 776 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 835
Query: 495 RERAQRAARAKQRQEGQLQREKREL---SRAERARHEALLQGRTRQQRQEREGL---RSS 548
++ + A A++ +E Q + E+ L A R RHE + R + Q ++ L R
Sbjct: 836 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 895
Query: 549 LEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRS 608
+ +L R Q+ + + +++ T ++S + +S A S +K+ EE
Sbjct: 896 QQEALRRLQQQQQQQQLA-QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER---- 950
Query: 609 FDRMVREAQ 617
+R +RE Q
Sbjct: 951 -ERQLREEQ 958
Score = 44.3 bits (103), Expect = 3e-04
Identities = 50/235 (21%), Positives = 108/235 (45%), Gaps = 11/235 (4%)
Query: 328 QTAQHVERIVRQVRAERGLRGVPE--RDRKIAALMLARHQEELLLLEQRAAAHGQWELQR 385
Q + + R+ + R E R E R ++ A AR +EE + + E R
Sbjct: 809 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 868
Query: 386 V-HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYER-SEERR 443
+ H ++ R+R+E E QR E R+ Q RR ++ +++++ A+ + ++
Sbjct: 869 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 928
Query: 444 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE--EGLQEGRERAEQIRRERAQRA 501
+ Q L ++ E+R R+L++EQ +QRE + LQ+ +++ +Q +
Sbjct: 929 TTACQSQATLSLAEIQK-LEEERERQLREEQRRQQRELMKALQQQQQQQQQ-KLSGWGNV 986
Query: 502 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRA 556
++ + L+ ++ E + ++ + + Q + +Q + R S+L S+G +
Sbjct: 987 SKPSGTTKSLLEIQQEEARQMQKQQQQ---QQQHQQPNRARNNTHSNLHTSIGNS 1038
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 86.3 bits (212), Expect = 8e-17
Identities = 78/244 (31%), Positives = 119/244 (48%), Gaps = 31/244 (12%)
Query: 366 EELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRAL-EQGRRAWAAQVEERRGRRGRE 424
E+L LE+ AA + E + + +RE EER++Q L Q Q EE R RR E
Sbjct: 745 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 804
Query: 425 E-----REAARRRQRQYERSEERRRELAERQGL---------LRRERAERAAREDRLRKL 470
E +E A RRQR+ E + R+RE ERQ RRE ER +E+ LRK
Sbjct: 805 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 864
Query: 471 QQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQRE-----KRELSRAERA 525
++E REE +E + R E+ R + AAR + +E + ++E ++EL R +
Sbjct: 865 EEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 922
Query: 526 RHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-------HLAIGRKL--ERSEQLT 576
+ EAL + + +QQ+Q+ ++ ++ G+ LA +KL ER QL
Sbjct: 923 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 982
Query: 577 RERR 580
E+R
Sbjct: 983 EEQR 986
Score = 74.3 bits (181), Expect = 3e-13
Identities = 77/280 (27%), Positives = 127/280 (45%), Gaps = 20/280 (7%)
Query: 331 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQE-ELLLLEQRAAAHGQWELQRVHA- 388
Q E + RQ ER R E R+ L R +E E+ L QR Q + + +
Sbjct: 785 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 844
Query: 389 -KQRREREEREKQRAL----EQGRRAWAAQVEERRGR----RGREEREAARRRQRQYERS 439
++RRE EER KQ L E+ WA + EE + R R R E EAAR R +E
Sbjct: 845 EERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR---HEEE 901
Query: 440 EERRREL-AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERA 498
E +R+EL +RQ L R+R ++ RL++ QQ+Q L Q + L +Q
Sbjct: 902 ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK--LPSSSTWGQQSNTTAC 959
Query: 499 QRAARAKQRQEGQLQREK-RELSRAERARHEALLQGRTRQQRQEREGLR--SSLEASLGR 555
Q A + +L+ E+ R+L +R + L++ +QQ+Q+++ L ++ G
Sbjct: 960 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 1019
Query: 556 AQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 595
+ E + + +Q +++ AR+ ++ H
Sbjct: 1020 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1059
Score = 72.4 bits (176), Expect = 1e-12
Identities = 69/249 (27%), Positives = 120/249 (48%), Gaps = 25/249 (10%)
Query: 388 AKQRREREEREKQRALEQGR-----RAWAAQVEERRGRRGREEREAARRRQRQYERSEER 442
A ++ ++ E+ K LEQ R RA + E +R R ++E RRQ++ ER
Sbjct: 743 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 802
Query: 443 RRELAER--QGLLRRER----AERAAREDRLRKLQQE--QNLKQREEGLQEGRERAEQIR 494
ELA R + LRR+R A R RE+ R+ Q+E + L++R +E R++ E +R
Sbjct: 803 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 862
Query: 495 RERAQRAARAKQRQEGQLQREKREL---SRAERARHEALLQGRTRQQRQEREGL---RSS 548
++ + A A++ +E Q + E+ L A R RHE + R + Q ++ L R
Sbjct: 863 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 922
Query: 549 LEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRS 608
+ +L R Q+ + + +++ T ++S + +S A S +K+ EE
Sbjct: 923 QQEALRRLQQQQQQQQLA-QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER---- 977
Query: 609 FDRMVREAQ 617
+R +RE Q
Sbjct: 978 -ERQLREEQ 985
Score = 44.3 bits (103), Expect = 3e-04
Identities = 50/235 (21%), Positives = 108/235 (45%), Gaps = 11/235 (4%)
Query: 328 QTAQHVERIVRQVRAERGLRGVPE--RDRKIAALMLARHQEELLLLEQRAAAHGQWELQR 385
Q + + R+ + R E R E R ++ A AR +EE + + E R
Sbjct: 836 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 895
Query: 386 V-HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYER-SEERR 443
+ H ++ R+R+E E QR E R+ Q RR ++ +++++ A+ + ++
Sbjct: 896 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 955
Query: 444 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE--EGLQEGRERAEQIRRERAQRA 501
+ Q L ++ E+R R+L++EQ +QRE + LQ+ +++ +Q +
Sbjct: 956 TTACQSQATLSLAEIQK-LEEERERQLREEQRRQQRELMKALQQQQQQQQQ-KLSGWGNV 1013
Query: 502 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRA 556
++ + L+ ++ E + ++ + + Q + +Q + R S+L S+G +
Sbjct: 1014 SKPSGTTKSLLEIQQEEARQMQKQQQQ---QQQHQQPNRARNNTHSNLHTSIGNS 1065
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 86.3 bits (212), Expect = 8e-17
Identities = 78/244 (31%), Positives = 119/244 (48%), Gaps = 31/244 (12%)
Query: 366 EELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRAL-EQGRRAWAAQVEERRGRRGRE 424
E+L LE+ AA + E + + +RE EER++Q L Q Q EE R RR E
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 783
Query: 425 E-----REAARRRQRQYERSEERRRELAERQGL---------LRRERAERAAREDRLRKL 470
E +E A RRQR+ E + R+RE ERQ RRE ER +E+ LRK
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 843
Query: 471 QQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQRE-----KRELSRAERA 525
++E REE +E + R E+ R + AAR + +E + ++E ++EL R +
Sbjct: 844 EEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901
Query: 526 RHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-------HLAIGRKL--ERSEQLT 576
+ EAL + + +QQ+Q+ ++ ++ G+ LA +KL ER QL
Sbjct: 902 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 961
Query: 577 RERR 580
E+R
Sbjct: 962 EEQR 965
Score = 74.3 bits (181), Expect = 3e-13
Identities = 77/280 (27%), Positives = 127/280 (45%), Gaps = 20/280 (7%)
Query: 331 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQE-ELLLLEQRAAAHGQWELQRVHA- 388
Q E + RQ ER R E R+ L R +E E+ L QR Q + + +
Sbjct: 764 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 823
Query: 389 -KQRREREEREKQRAL----EQGRRAWAAQVEERRGR----RGREEREAARRRQRQYERS 439
++RRE EER KQ L E+ WA + EE + R R R E EAAR R +E
Sbjct: 824 EERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR---HEEE 880
Query: 440 EERRREL-AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERA 498
E +R+EL +RQ L R+R ++ RL++ QQ+Q L Q + L +Q
Sbjct: 881 ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK--LPSSSTWGQQSNTTAC 938
Query: 499 QRAARAKQRQEGQLQREK-RELSRAERARHEALLQGRTRQQRQEREGLR--SSLEASLGR 555
Q A + +L+ E+ R+L +R + L++ +QQ+Q+++ L ++ G
Sbjct: 939 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 998
Query: 556 AQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 595
+ E + + +Q +++ AR+ ++ H
Sbjct: 999 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1038
Score = 72.4 bits (176), Expect = 1e-12
Identities = 69/249 (27%), Positives = 120/249 (48%), Gaps = 25/249 (10%)
Query: 388 AKQRREREEREKQRALEQGR-----RAWAAQVEERRGRRGREEREAARRRQRQYERSEER 442
A ++ ++ E+ K LEQ R RA + E +R R ++E RRQ++ ER
Sbjct: 722 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 781
Query: 443 RRELAER--QGLLRRER----AERAAREDRLRKLQQE--QNLKQREEGLQEGRERAEQIR 494
ELA R + LRR+R A R RE+ R+ Q+E + L++R +E R++ E +R
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 841
Query: 495 RERAQRAARAKQRQEGQLQREKREL---SRAERARHEALLQGRTRQQRQEREGL---RSS 548
++ + A A++ +E Q + E+ L A R RHE + R + Q ++ L R
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901
Query: 549 LEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRS 608
+ +L R Q+ + + +++ T ++S + +S A S +K+ EE
Sbjct: 902 QQEALRRLQQQQQQQQLA-QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER---- 956
Query: 609 FDRMVREAQ 617
+R +RE Q
Sbjct: 957 -ERQLREEQ 964
Score = 44.3 bits (103), Expect = 3e-04
Identities = 50/235 (21%), Positives = 108/235 (45%), Gaps = 11/235 (4%)
Query: 328 QTAQHVERIVRQVRAERGLRGVPE--RDRKIAALMLARHQEELLLLEQRAAAHGQWELQR 385
Q + + R+ + R E R E R ++ A AR +EE + + E R
Sbjct: 815 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 874
Query: 386 V-HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYER-SEERR 443
+ H ++ R+R+E E QR E R+ Q RR ++ +++++ A+ + ++
Sbjct: 875 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 934
Query: 444 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE--EGLQEGRERAEQIRRERAQRA 501
+ Q L ++ E+R R+L++EQ +QRE + LQ+ +++ +Q +
Sbjct: 935 TTACQSQATLSLAEIQK-LEEERERQLREEQRRQQRELMKALQQQQQQQQQ-KLSGWGNV 992
Query: 502 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRA 556
++ + L+ ++ E + ++ + + Q + +Q + R S+L S+G +
Sbjct: 993 SKPSGTTKSLLEIQQEEARQMQKQQQQ---QQQHQQPNRARNNTHSNLHTSIGNS 1044
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 86.3 bits (212), Expect = 8e-17
Identities = 78/244 (31%), Positives = 119/244 (48%), Gaps = 31/244 (12%)
Query: 366 EELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRAL-EQGRRAWAAQVEERRGRRGRE 424
E+L LE+ AA + E + + +RE EER++Q L Q Q EE R RR E
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 783
Query: 425 E-----REAARRRQRQYERSEERRRELAERQGL---------LRRERAERAAREDRLRKL 470
E +E A RRQR+ E + R+RE ERQ RRE ER +E+ LRK
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 843
Query: 471 QQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQRE-----KRELSRAERA 525
++E REE +E + R E+ R + AAR + +E + ++E ++EL R +
Sbjct: 844 EEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901
Query: 526 RHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-------HLAIGRKL--ERSEQLT 576
+ EAL + + +QQ+Q+ ++ ++ G+ LA +KL ER QL
Sbjct: 902 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 961
Query: 577 RERR 580
E+R
Sbjct: 962 EEQR 965
Score = 74.3 bits (181), Expect = 3e-13
Identities = 77/280 (27%), Positives = 127/280 (45%), Gaps = 20/280 (7%)
Query: 331 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQE-ELLLLEQRAAAHGQWELQRVHA- 388
Q E + RQ ER R E R+ L R +E E+ L QR Q + + +
Sbjct: 764 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 823
Query: 389 -KQRREREEREKQRAL----EQGRRAWAAQVEERRGR----RGREEREAARRRQRQYERS 439
++RRE EER KQ L E+ WA + EE + R R R E EAAR R +E
Sbjct: 824 EERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR---HEEE 880
Query: 440 EERRREL-AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERA 498
E +R+EL +RQ L R+R ++ RL++ QQ+Q L Q + L +Q
Sbjct: 881 ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK--LPSSSTWGQQSNTTAC 938
Query: 499 QRAARAKQRQEGQLQREK-RELSRAERARHEALLQGRTRQQRQEREGLR--SSLEASLGR 555
Q A + +L+ E+ R+L +R + L++ +QQ+Q+++ L ++ G
Sbjct: 939 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 998
Query: 556 AQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 595
+ E + + +Q +++ AR+ ++ H
Sbjct: 999 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1038
Score = 72.4 bits (176), Expect = 1e-12
Identities = 69/249 (27%), Positives = 120/249 (48%), Gaps = 25/249 (10%)
Query: 388 AKQRREREEREKQRALEQGR-----RAWAAQVEERRGRRGREEREAARRRQRQYERSEER 442
A ++ ++ E+ K LEQ R RA + E +R R ++E RRQ++ ER
Sbjct: 722 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 781
Query: 443 RRELAER--QGLLRRER----AERAAREDRLRKLQQE--QNLKQREEGLQEGRERAEQIR 494
ELA R + LRR+R A R RE+ R+ Q+E + L++R +E R++ E +R
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 841
Query: 495 RERAQRAARAKQRQEGQLQREKREL---SRAERARHEALLQGRTRQQRQEREGL---RSS 548
++ + A A++ +E Q + E+ L A R RHE + R + Q ++ L R
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901
Query: 549 LEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRS 608
+ +L R Q+ + + +++ T ++S + +S A S +K+ EE
Sbjct: 902 QQEALRRLQQQQQQQQLA-QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER---- 956
Query: 609 FDRMVREAQ 617
+R +RE Q
Sbjct: 957 -ERQLREEQ 964
Score = 44.3 bits (103), Expect = 3e-04
Identities = 50/235 (21%), Positives = 108/235 (45%), Gaps = 11/235 (4%)
Query: 328 QTAQHVERIVRQVRAERGLRGVPE--RDRKIAALMLARHQEELLLLEQRAAAHGQWELQR 385
Q + + R+ + R E R E R ++ A AR +EE + + E R
Sbjct: 815 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 874
Query: 386 V-HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYER-SEERR 443
+ H ++ R+R+E E QR E R+ Q RR ++ +++++ A+ + ++
Sbjct: 875 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 934
Query: 444 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE--EGLQEGRERAEQIRRERAQRA 501
+ Q L ++ E+R R+L++EQ +QRE + LQ+ +++ +Q +
Sbjct: 935 TTACQSQATLSLAEIQK-LEEERERQLREEQRRQQRELMKALQQQQQQQQQ-KLSGWGNV 992
Query: 502 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRA 556
++ + L+ ++ E + ++ + + Q + +Q + R S+L S+G +
Sbjct: 993 SKPSGTTKSLLEIQQEEARQMQKQQQQ---QQQHQQPNRARNNTHSNLHTSIGNS 1044
>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
Length = 202
Score = 80.9 bits (198), Expect = 3e-15
Identities = 55/178 (30%), Positives = 93/178 (52%), Gaps = 5/178 (2%)
Query: 382 ELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEE 441
E +R ++R + ERE + R Q + + R ++ER+ R+R+R+ ER E
Sbjct: 18 ERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQRQRERETERETE 77
Query: 442 RRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRA 501
R+RE ++ R+ ER DR RK + ++N RE + GRER +Q RER +
Sbjct: 78 RQRERQRQRERKRQTDRERDKDRDRERKRETDRN---RERNRKGGRERDKQTERERDRER 134
Query: 502 ARAKQRQ-EGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQE 558
R +QR+ E Q QRE++ + ER R A + R +++++ER+ R + R ++
Sbjct: 135 ERQRQRERERQRQRERKRETDRERQRW-AEREERKKERKKERKKERKEKKKEEKRRED 191
Score = 72.8 bits (177), Expect = 9e-13
Identities = 61/208 (29%), Positives = 99/208 (47%), Gaps = 18/208 (8%)
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 397
R+ +RG ERDR+ R +E E R H Q + R +Q +ER
Sbjct: 7 RKRETDRGKETERERDRQ-------RERENQTERENR---HRQRDRHRERDRQTDREKER 56
Query: 398 EKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRRELAERQGLLRRE 456
E+Q+ E+ R+ + ER R RE +R+ R+RQ ER ++R RE +R+ RE
Sbjct: 57 ERQK--ERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRE-RKRETDRNRE 113
Query: 457 RAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREK 516
R + RE + +Q + + RE Q RER Q +RER + R +QR + +R+K
Sbjct: 114 RNRKGGRE----RDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKK 169
Query: 517 RELSRAERARHEALLQGRTRQQRQEREG 544
++ R E + + R+ ++ + G
Sbjct: 170 ERKKERKKERKEKKKEEKRREDKKRKWG 197
Score = 70.5 bits (171), Expect = 4e-12
Identities = 53/192 (27%), Positives = 87/192 (45%), Gaps = 6/192 (3%)
Query: 390 QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAER 449
+R+ +RE R E R + ER + RE R R R R+ +R +R + ER
Sbjct: 2 ERQRERKRETDRGKETERE--RDRQRERENQTERENRHRQRDRHRERDRQTDREK---ER 56
Query: 450 QGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR-Q 508
+ R+R + RE +Q + +QRE Q RER + RER + R ++R +
Sbjct: 57 ERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNR 116
Query: 509 EGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRK 568
+G +R+K+ +R R + R RQ+++ER+ +E + RK
Sbjct: 117 KGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERK 176
Query: 569 LERSEQLTRERR 580
ER E+ E+R
Sbjct: 177 KERKEKKKEEKR 188
Score = 59.3 bits (142), Expect = 1e-08
Identities = 51/195 (26%), Positives = 83/195 (42%), Gaps = 9/195 (4%)
Query: 414 VEERRGRRGREEREAARRRQRQYERSEERR--RELAERQGLLRRERAERAAREDRLRKLQ 471
+E +R R+ +R R+R +R E + RE RQ RER + RE + +
Sbjct: 1 MERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQK 60
Query: 472 QEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALL 531
+ +QRE + ER + +R+R ++ ++R + + + KRE +R R
Sbjct: 61 ERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRE---TDRNRERNRK 117
Query: 532 QGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQL---TRERRSALESARS 588
GR R ++ ERE R E R +E R+ +R Q ER+ + R
Sbjct: 118 GGRERDKQTERERDRER-ERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERK 176
Query: 589 TARASFHVREKVREE 603
R EK RE+
Sbjct: 177 KERKEKKKEEKRRED 191
Score = 53.5 bits (127), Expect = 6e-07
Identities = 53/178 (29%), Positives = 75/178 (42%), Gaps = 24/178 (13%)
Query: 432 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 491
RQR+ +R +R +E ER+ +RER + RE+R R+ + RER
Sbjct: 3 RQRERKRETDRGKE-TERERDRQRERENQTERENRHRQRDRH-------------RERDR 48
Query: 492 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 551
Q RE+ + + + RQ QRE+ ER R + R RQ +ER+ R
Sbjct: 49 QTDREKERERQKERDRQR---QRERETERETERQRERQRQRERKRQTDRERDKDRDR--- 102
Query: 552 SLGRAQENYEHLAIGRK--LERSEQLTRERRSALESARSTARASFHVREKVREETNTR 607
R +E + RK ER +Q RER E R R RE+ RE R
Sbjct: 103 --ERKRETDRNRERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRER 158
Score = 44.3 bits (103), Expect = 3e-04
Identities = 46/178 (25%), Positives = 75/178 (42%), Gaps = 36/178 (20%)
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 387
Q +H ER RQ E+ ERDR+ R +E E Q E QR
Sbjct: 39 QRDRHRERD-RQTDREKERERQKERDRQ-------RQRER----ETERETERQRERQRQR 86
Query: 388 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE-------------------EREA 428
++R+ ER+K R E+ R + R+G R R+ ER+
Sbjct: 87 ERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTERERDRERERQRQRERERQR 146
Query: 429 ARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG 486
R R+R+ +R +R E ER+ ++ER +++R K ++E+ + ++ EG
Sbjct: 147 QRERKRETDRERQRWAEREERKKERKKER-----KKERKEKKKEEKRREDKKRKWGEG 199
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 80.5 bits (197), Expect = 4e-15
Identities = 57/237 (24%), Positives = 119/237 (50%), Gaps = 24/237 (10%)
Query: 371 LEQRAAAHGQWELQRV------------HAKQRREREEREKQRALEQGRRAWAAQVEERR 418
+ RAA ELQ V +++++ER EREK++ + R +E++
Sbjct: 5 ISSRAAVKLNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKK 64
Query: 419 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 478
R+ RE + R++++ E+ + RRE R+ +++ ER R R RK ++E+ K+
Sbjct: 65 KRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKER--KE 122
Query: 479 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 538
RE ++ RER + RR++ +R R ++++ G+ +R++++ + ER + + R R++
Sbjct: 123 RERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKK----RERNRKE 178
Query: 539 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 595
R++ + E R +E +K ER + +R++ + R ++F+
Sbjct: 179 RKKERERKERRERKKERKKER------RKKKERKKDRKTDRQTDSQVFRPLRESAFN 229
Score = 79.3 bits (194), Expect = 1e-14
Identities = 51/198 (25%), Positives = 104/198 (52%), Gaps = 9/198 (4%)
Query: 416 ERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQN 475
+R R +E RE R +R+ ER +ER+RE +++ R++R ER +R RK +++Q
Sbjct: 31 QRESERKKERRE---REKRKREREKERKRERGKKEKKKRKKR-ERGKERERKRKEREKQR 86
Query: 476 LKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRT 535
++RE+ + + + E+ +RER QR R +++++ + +RE+ R ER R + + R
Sbjct: 87 KERREK--ERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRR 144
Query: 536 RQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 595
+++++E+E + + + +E + RK + E+ +ERR + + R
Sbjct: 145 KERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKK-- 202
Query: 596 VREKVREETNTRSFDRMV 613
+E+ ++ R D V
Sbjct: 203 -KERKKDRKTDRQTDSQV 219
Score = 59.3 bits (142), Expect = 1e-08
Identities = 44/193 (22%), Positives = 88/193 (45%), Gaps = 13/193 (6%)
Query: 437 ERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRE 496
+R ER++E RRER +R ++ RK ++ + K++ + + G+ER E+ R+E
Sbjct: 31 QRESERKKE--------RREREKRKREREKERKRERGKKEKKKRKKRERGKER-ERKRKE 81
Query: 497 RAQRAARAKQRQEGQLQREKRELSRAERARHEAL----LQGRTRQQRQEREGLRSSLEAS 552
R ++ ++++ + ++EK++ R +R R E + R R+ +Q RE R
Sbjct: 82 REKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKK 141
Query: 553 LGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRM 612
R + E R+ +R ++ ER E R + +E+ + + R
Sbjct: 142 KRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRK 201
Query: 613 VREAQLHASLDRK 625
+E + DR+
Sbjct: 202 KKERKKDRKTDRQ 214
Score = 51.2 bits (121), Expect = 3e-06
Identities = 42/186 (22%), Positives = 95/186 (51%), Gaps = 17/186 (9%)
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 397
++ + ERG + +R ++ R ++E +QR + +R K++RER++R
Sbjct: 52 KERKRERGKKEKKKRKKRERGKERERKRKERE--KQRKERREKERRKRKKEKKKRERKQR 109
Query: 398 ----EKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLL 453
K++ + R Q ER+ ++ R+++ R++ + ER+R+
Sbjct: 110 GRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRK-------- 161
Query: 454 RRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQ-EGQL 512
+R++ ER + +R RK ++++ ++R+E + +ER ++ R+++ ++ R RQ + Q+
Sbjct: 162 KRKKEEREKKRERNRKERKKE--RERKERRERKKERKKERRKKKERKKDRKTDRQTDSQV 219
Query: 513 QREKRE 518
R RE
Sbjct: 220 FRPLRE 225
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 79.0 bits (193), Expect = 1e-14
Identities = 111/468 (23%), Positives = 188/468 (40%), Gaps = 35/468 (7%)
Query: 155 EAERRAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPAS 214
+AER AK Q R + + + REE + S + + + A
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1441
Query: 215 PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSS----- 269
A R+ + R Q + G L +L R E A + + A +
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1501
Query: 270 -YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRSFSLGDLSHSP 327
ES R+ + ++R A +A A L L R ++ +
Sbjct: 1502 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 387
Q +E R AE + + K A L + +E + + + R A + + Q+
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEAERRAQ-QQAE 1619
Query: 388 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
A++ RE ERE +R + A +++ + + +A +Q++ E RRR A
Sbjct: 1620 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679
Query: 448 ERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEGRERAEQIRRE 496
E Q + +RE AE+ + R ++L EQ L + E+G Q+ + E++ R
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 497 RAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---EGLRSSLEASL 553
+ + AA ++RQE + + K RA E LL + R + + R E + LEA
Sbjct: 1740 QREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1793
Query: 554 GRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 600
GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1794 GRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Score = 77.4 bits (189), Expect = 4e-14
Identities = 153/655 (23%), Positives = 242/655 (36%), Gaps = 120/655 (18%)
Query: 69 RKAEVPCAA-----AEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRS------LEAC 117
R+AEV A+ AE R +Q L L+ EAE R+ LE
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570
Query: 118 ARCAVKPVELLPRALAD----LVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERDRIM 173
R A ++ + A+ L R + VA L E EAERRA+ QQ AER R
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ-LRE--EAERRAQ-QQAEAERAREE 1626
Query: 174 REEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQ 233
E + + + A A + S + + A A R AR+ + A Q
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 234 PPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAG 293
A ++ + +++R A + + GE R+L A + A
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1746
Query: 294 S--------------------------ASSTTNAPGRPSALTLVPITGRSFSLGDLSHSP 327
+ A + + S L GR L + +
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1806
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLA-------RHQEELLLLEQRAAAHGQ 380
+ + RQ+ E R E +R +A + A + + E+ L E+ A
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866
Query: 381 WELQRVHAKQRREREEREKQ------RALEQGRRAWAAQVEERRG--------------- 419
L A QRR EE+ Q L Q R+A +++E ++G
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926
Query: 420 --------------------------------RRGREEREAARRRQRQYERSEERRRELA 447
R +E+ E RQRQ EERRR A
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
E + + + AE A R L++ + LK + E + RERAEQ E A++ A++
Sbjct: 1987 EER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ---ESARQLQLAQEA 2042
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQ------RQEREGL-RSSLEASLGRAQENY 560
+ +LQ E++ + A + + + L Q ++Q R E E R++ EA R Q
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102
Query: 561 EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
E R++E +E+L ++SA E A++ A+A EK+R+E + R E
Sbjct: 2103 EAAQSRRQVEEAERL---KQSAEEQAQARAQAQ-AAAEKLRKEAEQEAARRAQAE 2153
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/565 (22%), Positives = 223/565 (39%), Gaps = 56/565 (9%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1759
Query: 165 CRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKAS 224
RAE + ++ K R + + A + A+ + A A R+
Sbjct: 1760 VRAEME-VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818
Query: 225 PSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRA 284
+ A Q A K ++ +R + A E E LR L A
Sbjct: 1819 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-EDEA 1874
Query: 285 SARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA-- 342
R +A + R + L + G + + + + VE + ++A
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 343 ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE---- 396
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 1935 EKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992
Query: 397 ---------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 1993 SLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR----- 2046
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+ +
Sbjct: 2047 ----LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQ 2099
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLAIG 566
E + + +R++ AER + A Q + R Q Q E LR E R + E A+
Sbjct: 2100 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALR 2158
Query: 567 RKLERSEQLTRERRSALESARSTAR 591
+K ++ + ++ A ++ R A+
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQ 2183
Score = 66.2 bits (160), Expect = 8e-11
Identities = 118/500 (23%), Positives = 194/500 (38%), Gaps = 77/500 (15%)
Query: 155 EAER-RAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA 213
E ER +AK+++ R R+R +E R+L L+ AA A + + L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067
Query: 214 S------------PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSS 261
+ AAR+A+ AR Q +++ R+ + L + E +
Sbjct: 2068 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127
Query: 262 ESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVP 312
+ A +++ E RA A + ++ R A
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Query: 313 ITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLL 371
+T L + H ++ +++++AE +R + L R Q EEL L
Sbjct: 2188 LTTLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKL 2243
Query: 372 EQRAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR 430
+ R A + + R QR +EE EK + QV E R +EAAR
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAAR 2292
Query: 431 RRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERA 490
RQ LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A
Sbjct: 2293 LRQ------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELA 2339
Query: 491 EQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE 550
+ E+A+R K++ QL E + R A R RQ E R L
Sbjct: 2340 Q----EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLR 2388
Query: 551 -ASLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKV 600
A + RAQ E A IG KL R+E T+E+ + +++ + S H E++
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448
Query: 601 REETN--TRSFDRMVREAQL 618
RE R +++ +EA+L
Sbjct: 2449 REAIAELEREKEKLQQEAKL 2468
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 323 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 382
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1337 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1381
Query: 383 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 440
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1382 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 441 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 476
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496
Query: 477 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 530
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556
Query: 531 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 573
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1557 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 625
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 328 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 380
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033
Query: 381 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 431
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2088
Query: 432 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 491
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2089 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2136
Query: 492 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 551
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2189
Query: 552 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 602
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2190 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 351 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 405
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392
Query: 406 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 443
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2393 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452
Query: 444 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 501
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2511
Query: 502 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 561
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2512 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Query: 562 HLAIGRKLERSEQLTRERRSALE 584
+ RK E +QL ++RR E
Sbjct: 2565 --GVRRKQEELQQLEQQRRQQEE 2585
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 334 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 390
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2351 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2409
Query: 391 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 450
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 451 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 499
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2470 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2528
Query: 500 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 554
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2529 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2587
Query: 555 RAQENYEHLAIGRKLERSEQLTRERRSAL 583
A+EN R E+ + L + R+AL
Sbjct: 2588 -AEENQ------RLREQLQLLEEQHRAAL 2609
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 365 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 424
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2561
Query: 425 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 471
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621
Query: 472 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 518
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2622 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2681
Query: 519 LSRAERARHEALLQGRT 535
L+R E RH LQGR+
Sbjct: 2682 LARREDVRH--YLQGRS 2696
Score = 48.9 bits (115), Expect = 1e-05
Identities = 133/632 (21%), Positives = 225/632 (35%), Gaps = 91/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2152
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2212
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERDRIMREEKRR 179
A+ A RS M + L EAE RA + + + R ++EE +
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272
Query: 180 LFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA---------SPAPRAARKASPSPSSA 230
+ AA + AA A + A A A + A +
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 231 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 282
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2388
Query: 283 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 337
RA AR A G T + + + L Q + H +
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 391
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2449 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2504
Query: 392 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 451
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2557
Query: 452 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 511
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2558 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2597
Query: 512 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 571
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2598 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2654
Query: 572 SEQLTRERRSALESARSTARASFHVREKVREE 603
+++L + E + A+ V E R E
Sbjct: 2655 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2686
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 329 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 388
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1081 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1130
Query: 389 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 448
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1131 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1180
Query: 449 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 485
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240
Query: 486 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 526
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1300
Query: 527 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 573
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1360
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1361 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1399
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 79.0 bits (193), Expect = 1e-14
Identities = 111/468 (23%), Positives = 188/468 (40%), Gaps = 35/468 (7%)
Query: 155 EAERRAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPAS 214
+AER AK Q R + + + REE + S + + + A
Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1445
Query: 215 PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSS----- 269
A R+ + R Q + G L +L R E A + + A +
Sbjct: 1446 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1505
Query: 270 -YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRSFSLGDLSHSP 327
ES R+ + ++R A +A A L L R ++ +
Sbjct: 1506 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1565
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 387
Q +E R AE + + K A L + +E + + + R A + + Q+
Sbjct: 1566 QVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEAERRAQ-QQAE 1623
Query: 388 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
A++ RE ERE +R + A +++ + + +A +Q++ E RRR A
Sbjct: 1624 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1683
Query: 448 ERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEGRERAEQIRRE 496
E Q + +RE AE+ + R ++L EQ L + E+G Q+ + E++ R
Sbjct: 1684 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1743
Query: 497 RAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---EGLRSSLEASL 553
+ + AA ++RQE + + K RA E LL + R + + R E + LEA
Sbjct: 1744 QREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1797
Query: 554 GRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 600
GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1798 GRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1843
Score = 77.4 bits (189), Expect = 4e-14
Identities = 153/655 (23%), Positives = 242/655 (36%), Gaps = 120/655 (18%)
Query: 69 RKAEVPCAA-----AEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRS------LEAC 117
R+AEV A+ AE R +Q L L+ EAE R+ LE
Sbjct: 1515 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1574
Query: 118 ARCAVKPVELLPRALAD----LVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERDRIM 173
R A ++ + A+ L R + VA L E EAERRA+ QQ AER R
Sbjct: 1575 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ-LRE--EAERRAQ-QQAEAERAREE 1630
Query: 174 REEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQ 233
E + + + A A + S + + A A R AR+ + A Q
Sbjct: 1631 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1690
Query: 234 PPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAG 293
A ++ + +++R A + + GE R+L A + A
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1750
Query: 294 S--------------------------ASSTTNAPGRPSALTLVPITGRSFSLGDLSHSP 327
+ A + + S L GR L + +
Sbjct: 1751 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1810
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLA-------RHQEELLLLEQRAAAHGQ 380
+ + RQ+ E R E +R +A + A + + E+ L E+ A
Sbjct: 1811 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1870
Query: 381 WELQRVHAKQRREREEREKQ------RALEQGRRAWAAQVEERRG--------------- 419
L A QRR EE+ Q L Q R+A +++E ++G
Sbjct: 1871 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1930
Query: 420 --------------------------------RRGREEREAARRRQRQYERSEERRRELA 447
R +E+ E RQRQ EERRR A
Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1990
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
E + + + AE A R L++ + LK + E + RERAEQ E A++ A++
Sbjct: 1991 EER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ---ESARQLQLAQEA 2046
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQ------RQEREGL-RSSLEASLGRAQENY 560
+ +LQ E++ + A + + + L Q ++Q R E E R++ EA R Q
Sbjct: 2047 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2106
Query: 561 EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
E R++E +E+L ++SA E A++ A+A EK+R+E + R E
Sbjct: 2107 EAAQSRRQVEEAERL---KQSAEEQAQARAQAQ-AAAEKLRKEAEQEAARRAQAE 2157
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/565 (22%), Positives = 223/565 (39%), Gaps = 56/565 (9%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1712
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1713 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1763
Query: 165 CRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKAS 224
RAE + ++ K R + + A + A+ + A A R+
Sbjct: 1764 VRAEME-VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1822
Query: 225 PSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRA 284
+ A Q A K ++ +R + A E E LR L A
Sbjct: 1823 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-EDEA 1878
Query: 285 SARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA-- 342
R +A + R + L + G + + + + VE + ++A
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1938
Query: 343 ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE---- 396
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 1939 EKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1996
Query: 397 ---------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 1997 SLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR----- 2050
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+ +
Sbjct: 2051 ----LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQ 2103
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLAIG 566
E + + +R++ AER + A Q + R Q Q E LR E R + E A+
Sbjct: 2104 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALR 2162
Query: 567 RKLERSEQLTRERRSALESARSTAR 591
+K ++ + ++ A ++ R A+
Sbjct: 2163 QKQAADAEMEKHKKFAEQTLRQKAQ 2187
Score = 66.2 bits (160), Expect = 8e-11
Identities = 118/500 (23%), Positives = 194/500 (38%), Gaps = 77/500 (15%)
Query: 155 EAER-RAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA 213
E ER +AK+++ R R+R +E R+L L+ AA A + + L
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2071
Query: 214 S------------PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSS 261
+ AAR+A+ AR Q +++ R+ + L + E +
Sbjct: 2072 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2131
Query: 262 ESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVP 312
+ A +++ E RA A + ++ R A
Sbjct: 2132 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2191
Query: 313 ITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLL 371
+T L + H ++ +++++AE +R + L R Q EEL L
Sbjct: 2192 LTTLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKL 2247
Query: 372 EQRAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR 430
+ R A + + R QR +EE EK + QV E R +EAAR
Sbjct: 2248 KARIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAAR 2296
Query: 431 RRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERA 490
RQ LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A
Sbjct: 2297 LRQ------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELA 2343
Query: 491 EQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE 550
+ E+A+R K++ QL E + R A R RQ E R L
Sbjct: 2344 Q----EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLR 2392
Query: 551 -ASLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKV 600
A + RAQ E A IG KL R+E T+E+ + +++ + S H E++
Sbjct: 2393 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2452
Query: 601 REETN--TRSFDRMVREAQL 618
RE R +++ +EA+L
Sbjct: 2453 REAIAELEREKEKLQQEAKL 2472
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 323 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 382
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1341 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1385
Query: 383 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 440
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1386 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1440
Query: 441 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 476
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1441 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1500
Query: 477 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 530
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1501 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1560
Query: 531 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 573
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1561 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1619
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 625
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1620 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1671
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 328 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 380
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 1978 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2037
Query: 381 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 431
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2092
Query: 432 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 491
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2093 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2140
Query: 492 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 551
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2141 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2193
Query: 552 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 602
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2194 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 351 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 405
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2396
Query: 406 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 443
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2397 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2456
Query: 444 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 501
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2457 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2515
Query: 502 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 561
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2516 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2568
Query: 562 HLAIGRKLERSEQLTRERRSALE 584
+ RK E +QL ++RR E
Sbjct: 2569 --GVRRKQEELQQLEQQRRQQEE 2589
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 334 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 390
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2355 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2413
Query: 391 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 450
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2414 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2473
Query: 451 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 499
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2474 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2532
Query: 500 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 554
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2533 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2591
Query: 555 RAQENYEHLAIGRKLERSEQLTRERRSAL 583
A+EN R E+ + L + R+AL
Sbjct: 2592 -AEENQ------RLREQLQLLEEQHRAAL 2613
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 365 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 424
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2508 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2565
Query: 425 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 471
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2566 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2625
Query: 472 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 518
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2626 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2685
Query: 519 LSRAERARHEALLQGRT 535
L+R E RH LQGR+
Sbjct: 2686 LARREDVRH--YLQGRS 2700
Score = 48.9 bits (115), Expect = 1e-05
Identities = 133/632 (21%), Positives = 225/632 (35%), Gaps = 91/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2098 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2156
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2157 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2216
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERDRIMREEKRR 179
A+ A RS M + L EAE RA + + + R ++EE +
Sbjct: 2217 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2276
Query: 180 LFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA---------SPAPRAARKASPSPSSA 230
+ AA + AA A + A A A + A +
Sbjct: 2277 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2336
Query: 231 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 282
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2392
Query: 283 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 337
RA AR A G T + + + L Q + H +
Sbjct: 2393 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2452
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 391
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2453 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2508
Query: 392 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 451
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2509 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2561
Query: 452 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 511
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2562 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2601
Query: 512 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 571
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2602 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2658
Query: 572 SEQLTRERRSALESARSTARASFHVREKVREE 603
+++L + E + A+ V E R E
Sbjct: 2659 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2690
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 329 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 388
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1085 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1134
Query: 389 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 448
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1135 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1184
Query: 449 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 485
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1185 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1244
Query: 486 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 526
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1245 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1304
Query: 527 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 573
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1305 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1364
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1365 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1403
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 79.0 bits (193), Expect = 1e-14
Identities = 111/468 (23%), Positives = 188/468 (40%), Gaps = 35/468 (7%)
Query: 155 EAERRAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPAS 214
+AER AK Q R + + + REE + S + + + A
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1441
Query: 215 PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSS----- 269
A R+ + R Q + G L +L R E A + + A +
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1501
Query: 270 -YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRSFSLGDLSHSP 327
ES R+ + ++R A +A A L L R ++ +
Sbjct: 1502 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 387
Q +E R AE + + K A L + +E + + + R A + + Q+
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEAERRAQ-QQAE 1619
Query: 388 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
A++ RE ERE +R + A +++ + + +A +Q++ E RRR A
Sbjct: 1620 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679
Query: 448 ERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEGRERAEQIRRE 496
E Q + +RE AE+ + R ++L EQ L + E+G Q+ + E++ R
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 497 RAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---EGLRSSLEASL 553
+ + AA ++RQE + + K RA E LL + R + + R E + LEA
Sbjct: 1740 QREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1793
Query: 554 GRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 600
GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1794 GRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Score = 77.4 bits (189), Expect = 4e-14
Identities = 153/655 (23%), Positives = 242/655 (36%), Gaps = 120/655 (18%)
Query: 69 RKAEVPCAA-----AEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRS------LEAC 117
R+AEV A+ AE R +Q L L+ EAE R+ LE
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570
Query: 118 ARCAVKPVELLPRALAD----LVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERDRIM 173
R A ++ + A+ L R + VA L E EAERRA+ QQ AER R
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ-LRE--EAERRAQ-QQAEAERAREE 1626
Query: 174 REEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQ 233
E + + + A A + S + + A A R AR+ + A Q
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 234 PPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAG 293
A ++ + +++R A + + GE R+L A + A
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1746
Query: 294 S--------------------------ASSTTNAPGRPSALTLVPITGRSFSLGDLSHSP 327
+ A + + S L GR L + +
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1806
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLA-------RHQEELLLLEQRAAAHGQ 380
+ + RQ+ E R E +R +A + A + + E+ L E+ A
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866
Query: 381 WELQRVHAKQRREREEREKQ------RALEQGRRAWAAQVEERRG--------------- 419
L A QRR EE+ Q L Q R+A +++E ++G
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926
Query: 420 --------------------------------RRGREEREAARRRQRQYERSEERRRELA 447
R +E+ E RQRQ EERRR A
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
E + + + AE A R L++ + LK + E + RERAEQ E A++ A++
Sbjct: 1987 EER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ---ESARQLQLAQEA 2042
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQ------RQEREGL-RSSLEASLGRAQENY 560
+ +LQ E++ + A + + + L Q ++Q R E E R++ EA R Q
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102
Query: 561 EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
E R++E +E+L ++SA E A++ A+A EK+R+E + R E
Sbjct: 2103 EAAQSRRQVEEAERL---KQSAEEQAQARAQAQ-AAAEKLRKEAEQEAARRAQAE 2153
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/565 (22%), Positives = 223/565 (39%), Gaps = 56/565 (9%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1759
Query: 165 CRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKAS 224
RAE + ++ K R + + A + A+ + A A R+
Sbjct: 1760 VRAEME-VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818
Query: 225 PSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRA 284
+ A Q A K ++ +R + A E E LR L A
Sbjct: 1819 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-EDEA 1874
Query: 285 SARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA-- 342
R +A + R + L + G + + + + VE + ++A
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 343 ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE---- 396
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 1935 EKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992
Query: 397 ---------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 1993 SLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR----- 2046
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+ +
Sbjct: 2047 ----LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQ 2099
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLAIG 566
E + + +R++ AER + A Q + R Q Q E LR E R + E A+
Sbjct: 2100 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALR 2158
Query: 567 RKLERSEQLTRERRSALESARSTAR 591
+K ++ + ++ A ++ R A+
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQ 2183
Score = 66.2 bits (160), Expect = 8e-11
Identities = 118/500 (23%), Positives = 194/500 (38%), Gaps = 77/500 (15%)
Query: 155 EAER-RAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA 213
E ER +AK+++ R R+R +E R+L L+ AA A + + L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067
Query: 214 S------------PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSS 261
+ AAR+A+ AR Q +++ R+ + L + E +
Sbjct: 2068 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127
Query: 262 ESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVP 312
+ A +++ E RA A + ++ R A
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Query: 313 ITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLL 371
+T L + H ++ +++++AE +R + L R Q EEL L
Sbjct: 2188 LTTLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKL 2243
Query: 372 EQRAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR 430
+ R A + + R QR +EE EK + QV E R +EAAR
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAAR 2292
Query: 431 RRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERA 490
RQ LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A
Sbjct: 2293 LRQ------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELA 2339
Query: 491 EQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE 550
+ E+A+R K++ QL E + R A R RQ E R L
Sbjct: 2340 Q----EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLR 2388
Query: 551 -ASLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKV 600
A + RAQ E A IG KL R+E T+E+ + +++ + S H E++
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448
Query: 601 REETN--TRSFDRMVREAQL 618
RE R +++ +EA+L
Sbjct: 2449 REAIAELEREKEKLQQEAKL 2468
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 323 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 382
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1337 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1381
Query: 383 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 440
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1382 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 441 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 476
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496
Query: 477 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 530
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556
Query: 531 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 573
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1557 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 625
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 328 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 380
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033
Query: 381 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 431
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2088
Query: 432 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 491
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2089 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2136
Query: 492 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 551
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2189
Query: 552 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 602
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2190 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 351 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 405
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392
Query: 406 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 443
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2393 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452
Query: 444 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 501
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2511
Query: 502 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 561
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2512 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Query: 562 HLAIGRKLERSEQLTRERRSALE 584
+ RK E +QL ++RR E
Sbjct: 2565 --GVRRKQEELQQLEQQRRQQEE 2585
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 334 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 390
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2351 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2409
Query: 391 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 450
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 451 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 499
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2470 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2528
Query: 500 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 554
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2529 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2587
Query: 555 RAQENYEHLAIGRKLERSEQLTRERRSAL 583
A+EN R E+ + L + R+AL
Sbjct: 2588 -AEENQ------RLREQLQLLEEQHRAAL 2609
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 365 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 424
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2561
Query: 425 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 471
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621
Query: 472 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 518
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2622 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2681
Query: 519 LSRAERARHEALLQGRT 535
L+R E RH LQGR+
Sbjct: 2682 LARREDVRH--YLQGRS 2696
Score = 48.9 bits (115), Expect = 1e-05
Identities = 133/632 (21%), Positives = 225/632 (35%), Gaps = 91/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2152
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2212
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERDRIMREEKRR 179
A+ A RS M + L EAE RA + + + R ++EE +
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272
Query: 180 LFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA---------SPAPRAARKASPSPSSA 230
+ AA + AA A + A A A + A +
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 231 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 282
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2388
Query: 283 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 337
RA AR A G T + + + L Q + H +
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 391
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2449 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2504
Query: 392 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 451
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2557
Query: 452 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 511
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2558 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2597
Query: 512 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 571
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2598 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2654
Query: 572 SEQLTRERRSALESARSTARASFHVREKVREE 603
+++L + E + A+ V E R E
Sbjct: 2655 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2686
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 329 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 388
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1081 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1130
Query: 389 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 448
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1131 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1180
Query: 449 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 485
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240
Query: 486 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 526
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1300
Query: 527 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 573
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1360
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1361 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1399
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 79.0 bits (193), Expect = 1e-14
Identities = 111/468 (23%), Positives = 188/468 (40%), Gaps = 35/468 (7%)
Query: 155 EAERRAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPAS 214
+AER AK Q R + + + REE + S + + + A
Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1409
Query: 215 PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSS----- 269
A R+ + R Q + G L +L R E A + + A +
Sbjct: 1410 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1469
Query: 270 -YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRSFSLGDLSHSP 327
ES R+ + ++R A +A A L L R ++ +
Sbjct: 1470 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1529
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 387
Q +E R AE + + K A L + +E + + + R A + + Q+
Sbjct: 1530 QVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEAERRAQ-QQAE 1587
Query: 388 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
A++ RE ERE +R + A +++ + + +A +Q++ E RRR A
Sbjct: 1588 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1647
Query: 448 ERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEGRERAEQIRRE 496
E Q + +RE AE+ + R ++L EQ L + E+G Q+ + E++ R
Sbjct: 1648 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1707
Query: 497 RAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---EGLRSSLEASL 553
+ + AA ++RQE + + K RA E LL + R + + R E + LEA
Sbjct: 1708 QREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1761
Query: 554 GRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 600
GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1762 GRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1807
Score = 77.4 bits (189), Expect = 4e-14
Identities = 153/655 (23%), Positives = 242/655 (36%), Gaps = 120/655 (18%)
Query: 69 RKAEVPCAA-----AEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRS------LEAC 117
R+AEV A+ AE R +Q L L+ EAE R+ LE
Sbjct: 1479 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1538
Query: 118 ARCAVKPVELLPRALAD----LVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERDRIM 173
R A ++ + A+ L R + VA L E EAERRA+ QQ AER R
Sbjct: 1539 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ-LRE--EAERRAQ-QQAEAERAREE 1594
Query: 174 REEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQ 233
E + + + A A + S + + A A R AR+ + A Q
Sbjct: 1595 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1654
Query: 234 PPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAG 293
A ++ + +++R A + + GE R+L A + A
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1714
Query: 294 S--------------------------ASSTTNAPGRPSALTLVPITGRSFSLGDLSHSP 327
+ A + + S L GR L + +
Sbjct: 1715 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1774
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLA-------RHQEELLLLEQRAAAHGQ 380
+ + RQ+ E R E +R +A + A + + E+ L E+ A
Sbjct: 1775 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1834
Query: 381 WELQRVHAKQRREREEREKQ------RALEQGRRAWAAQVEERRG--------------- 419
L A QRR EE+ Q L Q R+A +++E ++G
Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1894
Query: 420 --------------------------------RRGREEREAARRRQRQYERSEERRRELA 447
R +E+ E RQRQ EERRR A
Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1954
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
E + + + AE A R L++ + LK + E + RERAEQ E A++ A++
Sbjct: 1955 EER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ---ESARQLQLAQEA 2010
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQ------RQEREGL-RSSLEASLGRAQENY 560
+ +LQ E++ + A + + + L Q ++Q R E E R++ EA R Q
Sbjct: 2011 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2070
Query: 561 EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
E R++E +E+L ++SA E A++ A+A EK+R+E + R E
Sbjct: 2071 EAAQSRRQVEEAERL---KQSAEEQAQARAQAQ-AAAEKLRKEAEQEAARRAQAE 2121
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/565 (22%), Positives = 223/565 (39%), Gaps = 56/565 (9%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1676
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1677 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1727
Query: 165 CRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKAS 224
RAE + ++ K R + + A + A+ + A A R+
Sbjct: 1728 VRAEME-VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1786
Query: 225 PSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRA 284
+ A Q A K ++ +R + A E E LR L A
Sbjct: 1787 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-EDEA 1842
Query: 285 SARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA-- 342
R +A + R + L + G + + + + VE + ++A
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1902
Query: 343 ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE---- 396
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 1903 EKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1960
Query: 397 ---------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 1961 SLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR----- 2014
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+ +
Sbjct: 2015 ----LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQ 2067
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLAIG 566
E + + +R++ AER + A Q + R Q Q E LR E R + E A+
Sbjct: 2068 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALR 2126
Query: 567 RKLERSEQLTRERRSALESARSTAR 591
+K ++ + ++ A ++ R A+
Sbjct: 2127 QKQAADAEMEKHKKFAEQTLRQKAQ 2151
Score = 66.2 bits (160), Expect = 8e-11
Identities = 118/500 (23%), Positives = 194/500 (38%), Gaps = 77/500 (15%)
Query: 155 EAER-RAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA 213
E ER +AK+++ R R+R +E R+L L+ AA A + + L
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2035
Query: 214 S------------PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSS 261
+ AAR+A+ AR Q +++ R+ + L + E +
Sbjct: 2036 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2095
Query: 262 ESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVP 312
+ A +++ E RA A + ++ R A
Sbjct: 2096 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2155
Query: 313 ITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLL 371
+T L + H ++ +++++AE +R + L R Q EEL L
Sbjct: 2156 LTTLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKL 2211
Query: 372 EQRAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR 430
+ R A + + R QR +EE EK + QV E R +EAAR
Sbjct: 2212 KARIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAAR 2260
Query: 431 RRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERA 490
RQ LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A
Sbjct: 2261 LRQ------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELA 2307
Query: 491 EQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE 550
+ E+A+R K++ QL E + R A R RQ E R L
Sbjct: 2308 Q----EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLR 2356
Query: 551 -ASLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKV 600
A + RAQ E A IG KL R+E T+E+ + +++ + S H E++
Sbjct: 2357 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2416
Query: 601 REETN--TRSFDRMVREAQL 618
RE R +++ +EA+L
Sbjct: 2417 REAIAELEREKEKLQQEAKL 2436
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 323 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 382
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1305 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1349
Query: 383 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 440
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1350 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1404
Query: 441 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 476
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1405 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1464
Query: 477 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 530
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1465 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1524
Query: 531 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 573
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1525 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1583
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 625
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1584 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1635
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 328 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 380
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 1942 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2001
Query: 381 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 431
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2002 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2056
Query: 432 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 491
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2057 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2104
Query: 492 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 551
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2105 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2157
Query: 552 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 602
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2158 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 351 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 405
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2360
Query: 406 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 443
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2361 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2420
Query: 444 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 501
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2421 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2479
Query: 502 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 561
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2480 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2532
Query: 562 HLAIGRKLERSEQLTRERRSALE 584
+ RK E +QL ++RR E
Sbjct: 2533 --GVRRKQEELQQLEQQRRQQEE 2553
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 334 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 390
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2319 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2377
Query: 391 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 450
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2378 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2437
Query: 451 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 499
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2438 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2496
Query: 500 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 554
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2497 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2555
Query: 555 RAQENYEHLAIGRKLERSEQLTRERRSAL 583
A+EN R E+ + L + R+AL
Sbjct: 2556 -AEENQ------RLREQLQLLEEQHRAAL 2577
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 365 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 424
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2472 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2529
Query: 425 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 471
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2530 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2589
Query: 472 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 518
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2590 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2649
Query: 519 LSRAERARHEALLQGRT 535
L+R E RH LQGR+
Sbjct: 2650 LARREDVRH--YLQGRS 2664
Score = 48.9 bits (115), Expect = 1e-05
Identities = 133/632 (21%), Positives = 225/632 (35%), Gaps = 91/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2062 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2120
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2121 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2180
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERDRIMREEKRR 179
A+ A RS M + L EAE RA + + + R ++EE +
Sbjct: 2181 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2240
Query: 180 LFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA---------SPAPRAARKASPSPSSA 230
+ AA + AA A + A A A + A +
Sbjct: 2241 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2300
Query: 231 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 282
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2356
Query: 283 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 337
RA AR A G T + + + L Q + H +
Sbjct: 2357 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2416
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 391
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2417 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2472
Query: 392 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 451
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2473 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2525
Query: 452 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 511
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2526 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2565
Query: 512 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 571
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2566 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2622
Query: 572 SEQLTRERRSALESARSTARASFHVREKVREE 603
+++L + E + A+ V E R E
Sbjct: 2623 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2654
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 329 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 388
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1049 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1098
Query: 389 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 448
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1099 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1148
Query: 449 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 485
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1149 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1208
Query: 486 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 526
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1209 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1268
Query: 527 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 573
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1269 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1328
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1329 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1367
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 79.0 bits (193), Expect = 1e-14
Identities = 111/468 (23%), Positives = 188/468 (40%), Gaps = 35/468 (7%)
Query: 155 EAERRAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPAS 214
+AER AK Q R + + + REE + S + + + A
Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1578
Query: 215 PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSS----- 269
A R+ + R Q + G L +L R E A + + A +
Sbjct: 1579 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1638
Query: 270 -YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRSFSLGDLSHSP 327
ES R+ + ++R A +A A L L R ++ +
Sbjct: 1639 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1698
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 387
Q +E R AE + + K A L + +E + + + R A + + Q+
Sbjct: 1699 QVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEAERRAQ-QQAE 1756
Query: 388 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
A++ RE ERE +R + A +++ + + +A +Q++ E RRR A
Sbjct: 1757 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1816
Query: 448 ERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEGRERAEQIRRE 496
E Q + +RE AE+ + R ++L EQ L + E+G Q+ + E++ R
Sbjct: 1817 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1876
Query: 497 RAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---EGLRSSLEASL 553
+ + AA ++RQE + + K RA E LL + R + + R E + LEA
Sbjct: 1877 QREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1930
Query: 554 GRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 600
GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1931 GRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976
Score = 77.4 bits (189), Expect = 4e-14
Identities = 153/655 (23%), Positives = 242/655 (36%), Gaps = 120/655 (18%)
Query: 69 RKAEVPCAA-----AEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRS------LEAC 117
R+AEV A+ AE R +Q L L+ EAE R+ LE
Sbjct: 1648 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1707
Query: 118 ARCAVKPVELLPRALAD----LVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERDRIM 173
R A ++ + A+ L R + VA L E EAERRA+ QQ AER R
Sbjct: 1708 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ-LRE--EAERRAQ-QQAEAERAREE 1763
Query: 174 REEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQ 233
E + + + A A + S + + A A R AR+ + A Q
Sbjct: 1764 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1823
Query: 234 PPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAG 293
A ++ + +++R A + + GE R+L A + A
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1883
Query: 294 S--------------------------ASSTTNAPGRPSALTLVPITGRSFSLGDLSHSP 327
+ A + + S L GR L + +
Sbjct: 1884 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1943
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLA-------RHQEELLLLEQRAAAHGQ 380
+ + RQ+ E R E +R +A + A + + E+ L E+ A
Sbjct: 1944 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 2003
Query: 381 WELQRVHAKQRREREEREKQ------RALEQGRRAWAAQVEERRG--------------- 419
L A QRR EE+ Q L Q R+A +++E ++G
Sbjct: 2004 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 2063
Query: 420 --------------------------------RRGREEREAARRRQRQYERSEERRRELA 447
R +E+ E RQRQ EERRR A
Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2123
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
E + + + AE A R L++ + LK + E + RERAEQ E A++ A++
Sbjct: 2124 EER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ---ESARQLQLAQEA 2179
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQ------RQEREGL-RSSLEASLGRAQENY 560
+ +LQ E++ + A + + + L Q ++Q R E E R++ EA R Q
Sbjct: 2180 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2239
Query: 561 EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
E R++E +E+L ++SA E A++ A+A EK+R+E + R E
Sbjct: 2240 EAAQSRRQVEEAERL---KQSAEEQAQARAQAQ-AAAEKLRKEAEQEAARRAQAE 2290
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/565 (22%), Positives = 223/565 (39%), Gaps = 56/565 (9%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1845
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1846 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1896
Query: 165 CRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKAS 224
RAE + ++ K R + + A + A+ + A A R+
Sbjct: 1897 VRAEME-VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1955
Query: 225 PSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRA 284
+ A Q A K ++ +R + A E E LR L A
Sbjct: 1956 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-EDEA 2011
Query: 285 SARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA-- 342
R +A + R + L + G + + + + VE + ++A
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 2071
Query: 343 ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE---- 396
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 2072 EKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2129
Query: 397 ---------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 2130 SLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR----- 2183
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+ +
Sbjct: 2184 ----LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQ 2236
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLAIG 566
E + + +R++ AER + A Q + R Q Q E LR E R + E A+
Sbjct: 2237 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALR 2295
Query: 567 RKLERSEQLTRERRSALESARSTAR 591
+K ++ + ++ A ++ R A+
Sbjct: 2296 QKQAADAEMEKHKKFAEQTLRQKAQ 2320
Score = 66.2 bits (160), Expect = 8e-11
Identities = 118/500 (23%), Positives = 194/500 (38%), Gaps = 77/500 (15%)
Query: 155 EAER-RAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA 213
E ER +AK+++ R R+R +E R+L L+ AA A + + L
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2204
Query: 214 S------------PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSS 261
+ AAR+A+ AR Q +++ R+ + L + E +
Sbjct: 2205 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2264
Query: 262 ESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVP 312
+ A +++ E RA A + ++ R A
Sbjct: 2265 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2324
Query: 313 ITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLL 371
+T L + H ++ +++++AE +R + L R Q EEL L
Sbjct: 2325 LTTLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKL 2380
Query: 372 EQRAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR 430
+ R A + + R QR +EE EK + QV E R +EAAR
Sbjct: 2381 KARIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAAR 2429
Query: 431 RRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERA 490
RQ LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A
Sbjct: 2430 LRQ------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELA 2476
Query: 491 EQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE 550
+ E+A+R K++ QL E + R A R RQ E R L
Sbjct: 2477 Q----EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLR 2525
Query: 551 -ASLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKV 600
A + RAQ E A IG KL R+E T+E+ + +++ + S H E++
Sbjct: 2526 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2585
Query: 601 REETN--TRSFDRMVREAQL 618
RE R +++ +EA+L
Sbjct: 2586 REAIAELEREKEKLQQEAKL 2605
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 323 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 382
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1474 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1518
Query: 383 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 440
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1519 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1573
Query: 441 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 476
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1574 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1633
Query: 477 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 530
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1634 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1693
Query: 531 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 573
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1694 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1752
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 625
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1753 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1804
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 328 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 380
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 2111 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2170
Query: 381 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 431
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2225
Query: 432 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 491
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2226 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2273
Query: 492 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 551
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2274 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2326
Query: 552 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 602
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2327 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 351 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 405
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2529
Query: 406 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 443
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2530 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2589
Query: 444 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 501
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2590 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2648
Query: 502 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 561
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2649 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2701
Query: 562 HLAIGRKLERSEQLTRERRSALE 584
+ RK E +QL ++RR E
Sbjct: 2702 --GVRRKQEELQQLEQQRRQQEE 2722
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 334 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 390
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2488 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2546
Query: 391 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 450
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2547 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606
Query: 451 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 499
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2607 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2665
Query: 500 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 554
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2666 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2724
Query: 555 RAQENYEHLAIGRKLERSEQLTRERRSAL 583
A+EN R E+ + L + R+AL
Sbjct: 2725 -AEENQ------RLREQLQLLEEQHRAAL 2746
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 365 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 424
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2641 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2698
Query: 425 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 471
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2699 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2758
Query: 472 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 518
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2759 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2818
Query: 519 LSRAERARHEALLQGRT 535
L+R E RH LQGR+
Sbjct: 2819 LARREDVRH--YLQGRS 2833
Score = 48.9 bits (115), Expect = 1e-05
Identities = 133/632 (21%), Positives = 225/632 (35%), Gaps = 91/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2231 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2289
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2290 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2349
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERDRIMREEKRR 179
A+ A RS M + L EAE RA + + + R ++EE +
Sbjct: 2350 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2409
Query: 180 LFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA---------SPAPRAARKASPSPSSA 230
+ AA + AA A + A A A + A +
Sbjct: 2410 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2469
Query: 231 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 282
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2525
Query: 283 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 337
RA AR A G T + + + L Q + H +
Sbjct: 2526 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2585
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 391
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2586 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2641
Query: 392 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 451
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2642 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2694
Query: 452 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 511
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2695 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2734
Query: 512 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 571
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2735 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2791
Query: 572 SEQLTRERRSALESARSTARASFHVREKVREE 603
+++L + E + A+ V E R E
Sbjct: 2792 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2823
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 329 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 388
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1218 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1267
Query: 389 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 448
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1268 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1317
Query: 449 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 485
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1318 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1377
Query: 486 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 526
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1378 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1437
Query: 527 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 573
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1438 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1497
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1498 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1536
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 79.0 bits (193), Expect = 1e-14
Identities = 111/468 (23%), Positives = 188/468 (40%), Gaps = 35/468 (7%)
Query: 155 EAERRAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPAS 214
+AER AK Q R + + + REE + S + + + A
Sbjct: 1363 QAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1419
Query: 215 PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSS----- 269
A R+ + R Q + G L +L R E A + + A +
Sbjct: 1420 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1479
Query: 270 -YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRSFSLGDLSHSP 327
ES R+ + ++R A +A A L L R ++ +
Sbjct: 1480 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1539
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 387
Q +E R AE + + K A L + +E + + + R A + + Q+
Sbjct: 1540 QVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEAERRAQ-QQAE 1597
Query: 388 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
A++ RE ERE +R + A +++ + + +A +Q++ E RRR A
Sbjct: 1598 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1657
Query: 448 ERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEGRERAEQIRRE 496
E Q + +RE AE+ + R ++L EQ L + E+G Q+ + E++ R
Sbjct: 1658 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1717
Query: 497 RAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---EGLRSSLEASL 553
+ + AA ++RQE + + K RA E LL + R + + R E + LEA
Sbjct: 1718 QREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1771
Query: 554 GRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 600
GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1772 GRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1817
Score = 77.4 bits (189), Expect = 4e-14
Identities = 153/655 (23%), Positives = 242/655 (36%), Gaps = 120/655 (18%)
Query: 69 RKAEVPCAA-----AEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRS------LEAC 117
R+AEV A+ AE R +Q L L+ EAE R+ LE
Sbjct: 1489 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1548
Query: 118 ARCAVKPVELLPRALAD----LVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERDRIM 173
R A ++ + A+ L R + VA L E EAERRA+ QQ AER R
Sbjct: 1549 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ-LRE--EAERRAQ-QQAEAERAREE 1604
Query: 174 REEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQ 233
E + + + A A + S + + A A R AR+ + A Q
Sbjct: 1605 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1664
Query: 234 PPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAG 293
A ++ + +++R A + + GE R+L A + A
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1724
Query: 294 S--------------------------ASSTTNAPGRPSALTLVPITGRSFSLGDLSHSP 327
+ A + + S L GR L + +
Sbjct: 1725 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1784
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLA-------RHQEELLLLEQRAAAHGQ 380
+ + RQ+ E R E +R +A + A + + E+ L E+ A
Sbjct: 1785 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1844
Query: 381 WELQRVHAKQRREREEREKQ------RALEQGRRAWAAQVEERRG--------------- 419
L A QRR EE+ Q L Q R+A +++E ++G
Sbjct: 1845 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1904
Query: 420 --------------------------------RRGREEREAARRRQRQYERSEERRRELA 447
R +E+ E RQRQ EERRR A
Sbjct: 1905 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1964
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
E + + + AE A R L++ + LK + E + RERAEQ E A++ A++
Sbjct: 1965 EER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ---ESARQLQLAQEA 2020
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQ------RQEREGL-RSSLEASLGRAQENY 560
+ +LQ E++ + A + + + L Q ++Q R E E R++ EA R Q
Sbjct: 2021 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2080
Query: 561 EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
E R++E +E+L ++SA E A++ A+A EK+R+E + R E
Sbjct: 2081 EAAQSRRQVEEAERL---KQSAEEQAQARAQAQ-AAAEKLRKEAEQEAARRAQAE 2131
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/565 (22%), Positives = 223/565 (39%), Gaps = 56/565 (9%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1686
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1687 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1737
Query: 165 CRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKAS 224
RAE + ++ K R + + A + A+ + A A R+
Sbjct: 1738 VRAEME-VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1796
Query: 225 PSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRA 284
+ A Q A K ++ +R + A E E LR L A
Sbjct: 1797 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-EDEA 1852
Query: 285 SARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA-- 342
R +A + R + L + G + + + + VE + ++A
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1912
Query: 343 ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE---- 396
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 1913 EKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1970
Query: 397 ---------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 1971 SLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR----- 2024
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+ +
Sbjct: 2025 ----LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQ 2077
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLAIG 566
E + + +R++ AER + A Q + R Q Q E LR E R + E A+
Sbjct: 2078 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALR 2136
Query: 567 RKLERSEQLTRERRSALESARSTAR 591
+K ++ + ++ A ++ R A+
Sbjct: 2137 QKQAADAEMEKHKKFAEQTLRQKAQ 2161
Score = 66.2 bits (160), Expect = 8e-11
Identities = 118/500 (23%), Positives = 194/500 (38%), Gaps = 77/500 (15%)
Query: 155 EAER-RAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA 213
E ER +AK+++ R R+R +E R+L L+ AA A + + L
Sbjct: 1988 EVERLKAKVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2045
Query: 214 S------------PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSS 261
+ AAR+A+ AR Q +++ R+ + L + E +
Sbjct: 2046 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2105
Query: 262 ESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVP 312
+ A +++ E RA A + ++ R A
Sbjct: 2106 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2165
Query: 313 ITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLL 371
+T L + H ++ +++++AE +R + L R Q EEL L
Sbjct: 2166 LTTLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKL 2221
Query: 372 EQRAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR 430
+ R A + + R QR +EE EK + QV E R +EAAR
Sbjct: 2222 KARIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAAR 2270
Query: 431 RRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERA 490
RQ LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A
Sbjct: 2271 LRQ------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELA 2317
Query: 491 EQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE 550
+ E+A+R K++ QL E + R A R RQ E R L
Sbjct: 2318 Q----EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLR 2366
Query: 551 -ASLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKV 600
A + RAQ E A IG KL R+E T+E+ + +++ + S H E++
Sbjct: 2367 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2426
Query: 601 REETN--TRSFDRMVREAQL 618
RE R +++ +EA+L
Sbjct: 2427 REAIAELEREKEKLQQEAKL 2446
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 323 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 382
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1315 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1359
Query: 383 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 440
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1360 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1414
Query: 441 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 476
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1415 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1474
Query: 477 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 530
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1475 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1534
Query: 531 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 573
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1535 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1593
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 625
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1594 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1645
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 328 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 380
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 1952 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2011
Query: 381 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 431
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2066
Query: 432 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 491
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2067 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2114
Query: 492 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 551
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2115 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2167
Query: 552 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 602
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2168 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 351 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 405
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2311 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2370
Query: 406 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 443
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2371 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2430
Query: 444 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 501
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2431 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2489
Query: 502 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 561
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2490 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2542
Query: 562 HLAIGRKLERSEQLTRERRSALE 584
+ RK E +QL ++RR E
Sbjct: 2543 --GVRRKQEELQQLEQQRRQQEE 2563
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 334 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 390
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2329 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2387
Query: 391 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 450
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2388 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447
Query: 451 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 499
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2448 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2506
Query: 500 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 554
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2507 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2565
Query: 555 RAQENYEHLAIGRKLERSEQLTRERRSAL 583
A+EN R E+ + L + R+AL
Sbjct: 2566 -AEENQ------RLREQLQLLEEQHRAAL 2587
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 365 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 424
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2482 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2539
Query: 425 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 471
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2540 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2599
Query: 472 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 518
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2600 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2659
Query: 519 LSRAERARHEALLQGRT 535
L+R E RH LQGR+
Sbjct: 2660 LARREDVRH--YLQGRS 2674
Score = 48.9 bits (115), Expect = 1e-05
Identities = 133/632 (21%), Positives = 225/632 (35%), Gaps = 91/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2072 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2130
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2131 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2190
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERDRIMREEKRR 179
A+ A RS M + L EAE RA + + + R ++EE +
Sbjct: 2191 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2250
Query: 180 LFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA---------SPAPRAARKASPSPSSA 230
+ AA + AA A + A A A + A +
Sbjct: 2251 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2310
Query: 231 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 282
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2311 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2366
Query: 283 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 337
RA AR A G T + + + L Q + H +
Sbjct: 2367 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2426
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 391
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2427 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2482
Query: 392 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 451
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2483 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2535
Query: 452 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 511
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2536 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2575
Query: 512 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 571
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2576 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2632
Query: 572 SEQLTRERRSALESARSTARASFHVREKVREE 603
+++L + E + A+ V E R E
Sbjct: 2633 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2664
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 329 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 388
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1059 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1108
Query: 389 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 448
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1109 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1158
Query: 449 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 485
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1159 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1218
Query: 486 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 526
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1219 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1278
Query: 527 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 573
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1279 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1338
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1339 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1377
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 79.0 bits (193), Expect = 1e-14
Identities = 111/468 (23%), Positives = 188/468 (40%), Gaps = 35/468 (7%)
Query: 155 EAERRAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPAS 214
+AER AK Q R + + + REE + S + + + A
Sbjct: 1371 QAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1427
Query: 215 PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSS----- 269
A R+ + R Q + G L +L R E A + + A +
Sbjct: 1428 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1487
Query: 270 -YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRSFSLGDLSHSP 327
ES R+ + ++R A +A A L L R ++ +
Sbjct: 1488 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1547
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 387
Q +E R AE + + K A L + +E + + + R A + + Q+
Sbjct: 1548 QVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEAERRAQ-QQAE 1605
Query: 388 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
A++ RE ERE +R + A +++ + + +A +Q++ E RRR A
Sbjct: 1606 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1665
Query: 448 ERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEGRERAEQIRRE 496
E Q + +RE AE+ + R ++L EQ L + E+G Q+ + E++ R
Sbjct: 1666 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1725
Query: 497 RAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---EGLRSSLEASL 553
+ + AA ++RQE + + K RA E LL + R + + R E + LEA
Sbjct: 1726 QREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1779
Query: 554 GRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 600
GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1780 GRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1825
Score = 77.4 bits (189), Expect = 4e-14
Identities = 153/655 (23%), Positives = 242/655 (36%), Gaps = 120/655 (18%)
Query: 69 RKAEVPCAA-----AEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRS------LEAC 117
R+AEV A+ AE R +Q L L+ EAE R+ LE
Sbjct: 1497 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1556
Query: 118 ARCAVKPVELLPRALAD----LVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERDRIM 173
R A ++ + A+ L R + VA L E EAERRA+ QQ AER R
Sbjct: 1557 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ-LRE--EAERRAQ-QQAEAERAREE 1612
Query: 174 REEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQ 233
E + + + A A + S + + A A R AR+ + A Q
Sbjct: 1613 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1672
Query: 234 PPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAG 293
A ++ + +++R A + + GE R+L A + A
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1732
Query: 294 S--------------------------ASSTTNAPGRPSALTLVPITGRSFSLGDLSHSP 327
+ A + + S L GR L + +
Sbjct: 1733 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1792
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLA-------RHQEELLLLEQRAAAHGQ 380
+ + RQ+ E R E +R +A + A + + E+ L E+ A
Sbjct: 1793 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1852
Query: 381 WELQRVHAKQRREREEREKQ------RALEQGRRAWAAQVEERRG--------------- 419
L A QRR EE+ Q L Q R+A +++E ++G
Sbjct: 1853 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1912
Query: 420 --------------------------------RRGREEREAARRRQRQYERSEERRRELA 447
R +E+ E RQRQ EERRR A
Sbjct: 1913 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1972
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
E + + + AE A R L++ + LK + E + RERAEQ E A++ A++
Sbjct: 1973 EER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ---ESARQLQLAQEA 2028
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQ------RQEREGL-RSSLEASLGRAQENY 560
+ +LQ E++ + A + + + L Q ++Q R E E R++ EA R Q
Sbjct: 2029 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2088
Query: 561 EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
E R++E +E+L ++SA E A++ A+A EK+R+E + R E
Sbjct: 2089 EAAQSRRQVEEAERL---KQSAEEQAQARAQAQ-AAAEKLRKEAEQEAARRAQAE 2139
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/565 (22%), Positives = 223/565 (39%), Gaps = 56/565 (9%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1694
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1695 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1745
Query: 165 CRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKAS 224
RAE + ++ K R + + A + A+ + A A R+
Sbjct: 1746 VRAEME-VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1804
Query: 225 PSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRA 284
+ A Q A K ++ +R + A E E LR L A
Sbjct: 1805 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-EDEA 1860
Query: 285 SARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA-- 342
R +A + R + L + G + + + + VE + ++A
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1920
Query: 343 ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE---- 396
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 1921 EKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1978
Query: 397 ---------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 1979 SLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR----- 2032
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+ +
Sbjct: 2033 ----LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQ 2085
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLAIG 566
E + + +R++ AER + A Q + R Q Q E LR E R + E A+
Sbjct: 2086 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALR 2144
Query: 567 RKLERSEQLTRERRSALESARSTAR 591
+K ++ + ++ A ++ R A+
Sbjct: 2145 QKQAADAEMEKHKKFAEQTLRQKAQ 2169
Score = 66.2 bits (160), Expect = 8e-11
Identities = 118/500 (23%), Positives = 194/500 (38%), Gaps = 77/500 (15%)
Query: 155 EAER-RAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA 213
E ER +AK+++ R R+R +E R+L L+ AA A + + L
Sbjct: 1996 EVERLKAKVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2053
Query: 214 S------------PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSS 261
+ AAR+A+ AR Q +++ R+ + L + E +
Sbjct: 2054 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2113
Query: 262 ESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVP 312
+ A +++ E RA A + ++ R A
Sbjct: 2114 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2173
Query: 313 ITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLL 371
+T L + H ++ +++++AE +R + L R Q EEL L
Sbjct: 2174 LTTLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKL 2229
Query: 372 EQRAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR 430
+ R A + + R QR +EE EK + QV E R +EAAR
Sbjct: 2230 KARIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAAR 2278
Query: 431 RRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERA 490
RQ LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A
Sbjct: 2279 LRQ------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELA 2325
Query: 491 EQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE 550
+ E+A+R K++ QL E + R A R RQ E R L
Sbjct: 2326 Q----EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLR 2374
Query: 551 -ASLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKV 600
A + RAQ E A IG KL R+E T+E+ + +++ + S H E++
Sbjct: 2375 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2434
Query: 601 REETN--TRSFDRMVREAQL 618
RE R +++ +EA+L
Sbjct: 2435 REAIAELEREKEKLQQEAKL 2454
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 323 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 382
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1323 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1367
Query: 383 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 440
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1368 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1422
Query: 441 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 476
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1423 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1482
Query: 477 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 530
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1483 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1542
Query: 531 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 573
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1543 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1601
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 625
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1602 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1653
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 328 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 380
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 1960 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2019
Query: 381 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 431
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2020 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2074
Query: 432 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 491
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2075 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2122
Query: 492 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 551
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2123 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2175
Query: 552 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 602
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2176 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2225
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 351 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 405
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2319 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2378
Query: 406 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 443
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2379 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2438
Query: 444 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 501
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2439 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2497
Query: 502 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 561
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2498 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2550
Query: 562 HLAIGRKLERSEQLTRERRSALE 584
+ RK E +QL ++RR E
Sbjct: 2551 --GVRRKQEELQQLEQQRRQQEE 2571
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 334 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 390
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2337 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2395
Query: 391 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 450
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2396 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2455
Query: 451 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 499
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2456 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2514
Query: 500 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 554
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2515 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2573
Query: 555 RAQENYEHLAIGRKLERSEQLTRERRSAL 583
A+EN R E+ + L + R+AL
Sbjct: 2574 -AEENQ------RLREQLQLLEEQHRAAL 2595
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 365 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 424
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2490 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2547
Query: 425 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 471
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2548 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2607
Query: 472 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 518
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2608 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2667
Query: 519 LSRAERARHEALLQGRT 535
L+R E RH LQGR+
Sbjct: 2668 LARREDVRH--YLQGRS 2682
Score = 48.9 bits (115), Expect = 1e-05
Identities = 133/632 (21%), Positives = 225/632 (35%), Gaps = 91/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2080 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2138
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2139 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2198
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERDRIMREEKRR 179
A+ A RS M + L EAE RA + + + R ++EE +
Sbjct: 2199 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2258
Query: 180 LFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA---------SPAPRAARKASPSPSSA 230
+ AA + AA A + A A A + A +
Sbjct: 2259 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2318
Query: 231 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 282
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2319 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2374
Query: 283 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 337
RA AR A G T + + + L Q + H +
Sbjct: 2375 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2434
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 391
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2435 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2490
Query: 392 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 451
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2491 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2543
Query: 452 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 511
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2544 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2583
Query: 512 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 571
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2584 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2640
Query: 572 SEQLTRERRSALESARSTARASFHVREKVREE 603
+++L + E + A+ V E R E
Sbjct: 2641 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2672
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 329 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 388
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1067 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1116
Query: 389 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 448
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1117 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1166
Query: 449 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 485
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1167 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1226
Query: 486 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 526
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1227 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1286
Query: 527 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 573
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1287 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1346
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1347 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1385
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 79.0 bits (193), Expect = 1e-14
Identities = 111/468 (23%), Positives = 188/468 (40%), Gaps = 35/468 (7%)
Query: 155 EAERRAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPAS 214
+AER AK Q R + + + REE + S + + + A
Sbjct: 1412 QAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1468
Query: 215 PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSS----- 269
A R+ + R Q + G L +L R E A + + A +
Sbjct: 1469 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1528
Query: 270 -YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRSFSLGDLSHSP 327
ES R+ + ++R A +A A L L R ++ +
Sbjct: 1529 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1588
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 387
Q +E R AE + + K A L + +E + + + R A + + Q+
Sbjct: 1589 QVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEAERRAQ-QQAE 1646
Query: 388 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
A++ RE ERE +R + A +++ + + +A +Q++ E RRR A
Sbjct: 1647 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1706
Query: 448 ERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEGRERAEQIRRE 496
E Q + +RE AE+ + R ++L EQ L + E+G Q+ + E++ R
Sbjct: 1707 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1766
Query: 497 RAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---EGLRSSLEASL 553
+ + AA ++RQE + + K RA E LL + R + + R E + LEA
Sbjct: 1767 QREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1820
Query: 554 GRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 600
GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1821 GRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1866
Score = 77.4 bits (189), Expect = 4e-14
Identities = 153/655 (23%), Positives = 242/655 (36%), Gaps = 120/655 (18%)
Query: 69 RKAEVPCAA-----AEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRS------LEAC 117
R+AEV A+ AE R +Q L L+ EAE R+ LE
Sbjct: 1538 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1597
Query: 118 ARCAVKPVELLPRALAD----LVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERDRIM 173
R A ++ + A+ L R + VA L E EAERRA+ QQ AER R
Sbjct: 1598 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ-LRE--EAERRAQ-QQAEAERAREE 1653
Query: 174 REEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQ 233
E + + + A A + S + + A A R AR+ + A Q
Sbjct: 1654 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1713
Query: 234 PPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAG 293
A ++ + +++R A + + GE R+L A + A
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1773
Query: 294 S--------------------------ASSTTNAPGRPSALTLVPITGRSFSLGDLSHSP 327
+ A + + S L GR L + +
Sbjct: 1774 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1833
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLA-------RHQEELLLLEQRAAAHGQ 380
+ + RQ+ E R E +R +A + A + + E+ L E+ A
Sbjct: 1834 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1893
Query: 381 WELQRVHAKQRREREEREKQ------RALEQGRRAWAAQVEERRG--------------- 419
L A QRR EE+ Q L Q R+A +++E ++G
Sbjct: 1894 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1953
Query: 420 --------------------------------RRGREEREAARRRQRQYERSEERRRELA 447
R +E+ E RQRQ EERRR A
Sbjct: 1954 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2013
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
E + + + AE A R L++ + LK + E + RERAEQ E A++ A++
Sbjct: 2014 EER-VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ---ESARQLQLAQEA 2069
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQ------RQEREGL-RSSLEASLGRAQENY 560
+ +LQ E++ + A + + + L Q ++Q R E E R++ EA R Q
Sbjct: 2070 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2129
Query: 561 EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
E R++E +E+L ++SA E A++ A+A EK+R+E + R E
Sbjct: 2130 EAAQSRRQVEEAERL---KQSAEEQAQARAQAQ-AAAEKLRKEAEQEAARRAQAE 2180
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/565 (22%), Positives = 223/565 (39%), Gaps = 56/565 (9%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1735
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1736 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1786
Query: 165 CRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKAS 224
RAE + ++ K R + + A + A+ + A A R+
Sbjct: 1787 VRAEME-VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1845
Query: 225 PSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRA 284
+ A Q A K ++ +R + A E E LR L A
Sbjct: 1846 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-EDEA 1901
Query: 285 SARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA-- 342
R +A + R + L + G + + + + VE + ++A
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1961
Query: 343 ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE---- 396
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 1962 EKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2019
Query: 397 ---------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 2020 SLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR----- 2073
Query: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+ +
Sbjct: 2074 ----LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQ 2126
Query: 508 QEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLAIG 566
E + + +R++ AER + A Q + R Q Q E LR E R + E A+
Sbjct: 2127 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALR 2185
Query: 567 RKLERSEQLTRERRSALESARSTAR 591
+K ++ + ++ A ++ R A+
Sbjct: 2186 QKQAADAEMEKHKKFAEQTLRQKAQ 2210
Score = 66.2 bits (160), Expect = 8e-11
Identities = 118/500 (23%), Positives = 194/500 (38%), Gaps = 77/500 (15%)
Query: 155 EAER-RAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA 213
E ER +AK+++ R R+R +E R+L L+ AA A + + L
Sbjct: 2037 EVERLKAKVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2094
Query: 214 S------------PAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSS 261
+ AAR+A+ AR Q +++ R+ + L + E +
Sbjct: 2095 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2154
Query: 262 ESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVP 312
+ A +++ E RA A + ++ R A
Sbjct: 2155 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2214
Query: 313 ITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLL 371
+T L + H ++ +++++AE +R + L R Q EEL L
Sbjct: 2215 LTTLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKL 2270
Query: 372 EQRAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR 430
+ R A + + R QR +EE EK + QV E R +EAAR
Sbjct: 2271 KARIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAAR 2319
Query: 431 RRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERA 490
RQ LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A
Sbjct: 2320 LRQ------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELA 2366
Query: 491 EQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE 550
+ E+A+R K++ QL E + R A R RQ E R L
Sbjct: 2367 Q----EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLR 2415
Query: 551 -ASLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKV 600
A + RAQ E A IG KL R+E T+E+ + +++ + S H E++
Sbjct: 2416 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2475
Query: 601 REETN--TRSFDRMVREAQL 618
RE R +++ +EA+L
Sbjct: 2476 REAIAELEREKEKLQQEAKL 2495
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 323 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 382
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1364 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1408
Query: 383 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 440
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1409 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1463
Query: 441 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 476
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1464 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1523
Query: 477 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 530
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1524 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1583
Query: 531 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 573
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1584 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1642
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 625
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1643 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1694
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 328 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 380
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 2001 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2060
Query: 381 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 431
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2115
Query: 432 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 491
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2116 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2163
Query: 492 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 551
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2164 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2216
Query: 552 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 602
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2217 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2266
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 351 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 405
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2360 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2419
Query: 406 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 443
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2420 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2479
Query: 444 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 501
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2480 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2538
Query: 502 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 561
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2539 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2591
Query: 562 HLAIGRKLERSEQLTRERRSALE 584
+ RK E +QL ++RR E
Sbjct: 2592 --GVRRKQEELQQLEQQRRQQEE 2612
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 334 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 390
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2378 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2436
Query: 391 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 450
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2437 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496
Query: 451 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 499
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2497 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2555
Query: 500 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 554
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2556 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2614
Query: 555 RAQENYEHLAIGRKLERSEQLTRERRSAL 583
A+EN R E+ + L + R+AL
Sbjct: 2615 -AEENQ------RLREQLQLLEEQHRAAL 2636
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 365 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 424
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2531 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2588
Query: 425 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 471
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2589 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2648
Query: 472 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 518
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2649 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2708
Query: 519 LSRAERARHEALLQGRT 535
L+R E RH LQGR+
Sbjct: 2709 LARREDVRH--YLQGRS 2723
Score = 48.9 bits (115), Expect = 1e-05
Identities = 133/632 (21%), Positives = 225/632 (35%), Gaps = 91/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2121 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2179
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2180 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2239
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERDRIMREEKRR 179
A+ A RS M + L EAE RA + + + R ++EE +
Sbjct: 2240 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2299
Query: 180 LFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPA---------SPAPRAARKASPSPSSA 230
+ AA + AA A + A A A + A +
Sbjct: 2300 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2359
Query: 231 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 282
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2360 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2415
Query: 283 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 337
RA AR A G T + + + L Q + H +
Sbjct: 2416 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2475
Query: 338 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 391
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2476 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2531
Query: 392 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 451
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2532 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2584
Query: 452 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 511
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2585 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2624
Query: 512 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 571
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2625 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2681
Query: 572 SEQLTRERRSALESARSTARASFHVREKVREE 603
+++L + E + A+ V E R E
Sbjct: 2682 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2713
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 329 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 388
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1108 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1157
Query: 389 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 448
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1158 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1207
Query: 449 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 485
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1208 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1267
Query: 486 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 526
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1268 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1327
Query: 527 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 573
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1328 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1387
Query: 574 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 615
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1388 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1426
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 78.2 bits (191), Expect = 2e-14
Identities = 94/349 (26%), Positives = 135/349 (38%), Gaps = 39/349 (11%)
Query: 218 RAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRE 277
R +R+ + P SR+ R +H R S SY LRE
Sbjct: 477 RDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLRE 536
Query: 278 LRWPPRASARNSCPAGSASSTTN-----APGRPSALTLVPITGRSFSLGDL--SHSPQTA 330
R RN S S N + GR L P G S G SHS +
Sbjct: 537 ES--SRTEIRNESRNESRSEIRNDRMGRSRGRVPEL---PEKGSRGSRGSQIDSHSSNSN 591
Query: 331 QHVERIVRQVRAERGLRGVPERDRKIAALMLA---RHQEELLLLEQRAAAHGQWELQRVH 387
H R ER PERD + A + RH E + ++
Sbjct: 592 YHDSWETRSSYPERDR--YPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQG 649
Query: 388 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRREL 446
ER+ER ++R +++ V++RR R RE +RE R R+R+ ER ER RE
Sbjct: 650 RNDELERDERREERRVDR--------VDDRRDERARERDRERERDRERERERERERDRE- 700
Query: 447 AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQ 506
E++ L RERA RE +++E + R+R RER + R K+
Sbjct: 701 REKERELERERARERERE------------REKERDRERDRDRDHDRERERERERDREKE 748
Query: 507 RQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGR 555
R+ + +RE+ ER R + R R++ +ERE R + GR
Sbjct: 749 REREREERERERERERERERERERERERARERDKERERQRDWEDKDKGR 797
Score = 73.2 bits (178), Expect = 7e-13
Identities = 71/276 (25%), Positives = 126/276 (45%), Gaps = 42/276 (15%)
Query: 384 QRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE-----EREAARRRQRQYER 438
+R ++R EREK+R LE+ R + E+ R R+ +RE R R+R E+
Sbjct: 688 ERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREK 747
Query: 439 SEERRRELAERQGLLRRERAERAARE-----DRLRKLQQEQNLKQREEGLQEGRERAEQI 493
ER RE ER+ RER RE +R ++ +++++ + +++G + RE+ E+I
Sbjct: 748 EREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEI 807
Query: 494 RRER------AQRAARAKQRQEG-----QLQREKRELSRAERA---------RHEALLQ- 532
R +R +R ++ + R EG Q + +RE S A +H L Q
Sbjct: 808 REDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQV 867
Query: 533 GRTRQQR--------QEREGLRSSLEASLGRAQEN--YEHLAIGRKLERSEQLTRERRSA 582
R ++ R ++R+G + R + + YE + K+ S RE+
Sbjct: 868 VRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVS-SVDKQREQTEI 926
Query: 583 LESARSTARASFHVREKVREETNTRSFDRMVREAQL 618
LES+R A+ + ET+ R+ D ++A++
Sbjct: 927 LESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKI 962
Score = 68.6 bits (166), Expect = 2e-11
Identities = 58/203 (28%), Positives = 99/203 (48%), Gaps = 15/203 (7%)
Query: 343 ERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRA 402
ER R ERD++ ++ + RHQ LE R + + RV ++ ER+++R
Sbjct: 628 ERDRRDNRERDQRPSSPI--RHQGRNDELE-RDERREERRVDRVDDRRDERARERDRERE 684
Query: 403 LEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRRELAERQGLLRRERAERA 461
++ R + +R + RE ERE AR R+R+ E+ +R R +R RER ER
Sbjct: 685 RDRERERERERERDREREKERELERERAREREREREKERDRER---DRDRDHDRER-ERE 740
Query: 462 AREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSR 521
DR ++ ++E+ ++RE + RER + RERA+ + ++RQ ++K R
Sbjct: 741 RERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDR 800
Query: 522 AERARHEALLQGRTRQQRQEREG 544
E+ + R+ R R+G
Sbjct: 801 REK-------REEIREDRNPRDG 816
Score = 65.9 bits (159), Expect = 1e-10
Identities = 118/489 (24%), Positives = 174/489 (35%), Gaps = 53/489 (10%)
Query: 169 RDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPS 228
RD + EKR SPA + +S + SS S SS SP+PR RK +PSPS
Sbjct: 302 RDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRH-SPSPR--RKRTPSPS 358
Query: 229 SARTQPPPAG-SRTGRKSHSLDSLSRR----REGALSSESGASSSSYSGESLRELRWPPR 283
RT PP S + SHSL S R+ R + E G + +S + R R
Sbjct: 359 YQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQS-HDRRHERR 417
Query: 284 ASARNSCPAGSAS------STTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVE-RI 336
R S + R P GR D + T E R
Sbjct: 418 EDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGR-----DRRDARDTRDRRELRD 472
Query: 337 VRQVRAERGLRGVPE-----RDRKIAALMLARH------------QEELLLLEQRAAA-- 377
R +R R +R RD + + H +E+ E R+
Sbjct: 473 SRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRN 532
Query: 378 HGQWELQRVHAKQRREREEREKQRALEQGR-RAWAAQVEERRGRRGREEREAARRRQRQY 436
H + E R + E R + R GR R ++ E+ R R + + Y
Sbjct: 533 HLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNY 592
Query: 437 ERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRE 496
S E R ER R+ ++A R+ + RE + Q R +
Sbjct: 593 HDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRND 652
Query: 497 RAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRA 556
+R R ++R+ ++ R ERAR + R R++ +ERE R R
Sbjct: 653 ELERDERREERRVDRVDDR-----RDERARERDRERERDRERERERERERD-------RE 700
Query: 557 QENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREA 616
+E L R ER + +ER + R R RE+ RE+ R + RE
Sbjct: 701 REKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERER 760
Query: 617 QLHASLDRK 625
+ +R+
Sbjct: 761 ERERERERE 769
Score = 62.0 bits (149), Expect = 2e-09
Identities = 62/240 (25%), Positives = 103/240 (42%), Gaps = 28/240 (11%)
Query: 378 HGQWELQRVHAKQRR--EREEREKQRALEQGRRAWAAQVEERRGRRGREEREAA--RRRQ 433
H WE + + ++ R ER+ R++ R RR +RR R R++R ++ R +
Sbjct: 593 HDSWETRSSYPERDRYPERDNRDQARDSSFERRHGE---RDRRDNRERDQRPSSPIRHQG 649
Query: 434 RQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQI 493
R E + RRE R + R ERA DR R+ +E+ ++RE RE+ ++
Sbjct: 650 RNDELERDERRE-ERRVDRVDDRRDERARERDRERERDRERE-RERERERDREREKEREL 707
Query: 494 RRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASL 553
RERA+ R ++++ R+ R H+ R R++ +ER+ +
Sbjct: 708 ERERAREREREREKE--------RDRERDRDRDHD-----RERERERERDREKERERERE 754
Query: 554 GRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS------FHVREKVREETNTR 607
R +E R+ ER + RER E R RE++RE+ N R
Sbjct: 755 ERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPR 814
Score = 49.7 bits (117), Expect = 8e-06
Identities = 89/415 (21%), Positives = 158/415 (38%), Gaps = 50/415 (12%)
Query: 186 PAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKS 245
P A A A + P+ ++++ ++A+ ++ A + A+P+ ++ T A + RK
Sbjct: 1104 PPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTF---ANEDSHRKC 1160
Query: 246 HSL-------------DSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPA 292
H D+ R+ S S S+ S + LR P SA S
Sbjct: 1161 HRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDD 1220
Query: 293 GSASSTTNAPG---RPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGV 349
S G R +L ITG S D + ++ + R+ R
Sbjct: 1221 QSGRKRVLHSGSRDREKTKSL-EITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSS 1279
Query: 350 PERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRA 409
PE DR++ + + + L R +E R ++RR+ +RE R ++
Sbjct: 1280 PESDRQVHSRSGSFDSRDRLQERDR------YEHDRERERERRDTRQREWDRDADKD--- 1330
Query: 410 WAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRK 469
W R+ R R+R+ ER ++RR+L + L + ER DR R
Sbjct: 1331 WP------------RNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRT 1378
Query: 470 LQQEQ--NLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREK--RELSRAERA 525
+ Q ++K+ E L+ ER + A K+R + L + E +++ER
Sbjct: 1379 FESSQIESVKRCEAKLEGEHER--DLESTSRDSLALDKERMDKDLGSVQGFEETNKSERT 1436
Query: 526 RHEALLQGRTRQQRQEREGLRSSL-EASLGRAQENYEHLAIGRKLERSEQLTRER 579
E+L G + + L S E + + + + G +R +Q E+
Sbjct: 1437 --ESLEAGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEK 1489
>gi|224593756 hypothetical protein LOC164127 [Homo sapiens]
Length = 623
Score = 77.4 bits (189), Expect = 4e-14
Identities = 72/272 (26%), Positives = 130/272 (47%), Gaps = 4/272 (1%)
Query: 349 VPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRR 408
V +D++I AL+L R ++ + E + A WE + ++ + ERE++ L Q +
Sbjct: 252 VSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQE 311
Query: 409 AWAAQVEERRGRRGREEREAARRRQRQ-YERSEERRRELAERQGLLRRERAERAAREDRL 467
W + E+R+ + E+R R QR+ E R +E E Q R+E+ E+A +
Sbjct: 312 QW-QEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEH 370
Query: 468 RKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARH 527
RK Q + L+++E+ L+ RE+ + R A R + + Q++ ++ + + +
Sbjct: 371 RKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINY 430
Query: 528 EALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESAR 587
+A Q + E + SLE S R+QE ++ L R+ E E+ +E L+ AR
Sbjct: 431 QARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQ-LQQAR 489
Query: 588 STARASFHVREKVREETNTRSFDRMVREAQLH 619
A S R K+R+ D +R+A+ H
Sbjct: 490 WRAGESEEQR-KMRKRILVELADEKIRQARSH 520
Score = 52.0 bits (123), Expect = 2e-06
Identities = 67/273 (24%), Positives = 120/273 (43%), Gaps = 33/273 (12%)
Query: 354 RKIAALMLARHQEELL--LLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWA 411
RK + R QE++L L EQ + Q + + V A ++R E Q+ ++ +
Sbjct: 371 RKQCQVRRLREQEKMLRNLREQHSL---QLQRRLVEACRKRHLHAVEGQKKVQDTNLSSL 427
Query: 412 AQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQ 471
+ R+ + + RQ E+S +R +E+ QG LR+ER +R RE ++ +
Sbjct: 428 INYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEI--HQG-LRKER-QRELREKAQKEEE 483
Query: 472 QEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREK----RELSRAERARH 527
Q Q + R +E R+ ++I E A R + + R+K REL+ H
Sbjct: 484 QLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNH 543
Query: 528 EALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESAR 587
L ++++ EG++ AI +K +R + +++ + + +
Sbjct: 544 HILKLKAEKEEKCHIEGIKE----------------AIKKKEQRVQHISQGKDPNFQEFQ 587
Query: 588 STARASFHVREKVREETNTRSFDRMVREAQLHA 620
+AS R + R N+ S D+MV EAQL A
Sbjct: 588 KLPQAS---RREERAPPNS-SLDQMVLEAQLRA 616
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 77.0 bits (188), Expect = 5e-14
Identities = 68/255 (26%), Positives = 110/255 (43%), Gaps = 20/255 (7%)
Query: 356 IAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVE 415
I A+ + + +L+ E +L+ K+ +ER+E EK+R + R E
Sbjct: 264 INAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERER------E 317
Query: 416 ERRGRRGRE-EREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQ 474
R RR RE ERE R R+++ ER ER R+ + R +R DR R+ ++
Sbjct: 318 RERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDR 377
Query: 475 NLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGR 534
N K R ++ R+R + RER + R ++R +RE+ ER R + R
Sbjct: 378 N-KDRSRSREKSRDRERERERERERERERERER-----EREREREREREREREREKDKKR 431
Query: 535 TRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASF 594
R++ +E R LE L + Y+ +L+ E RER+ E + R
Sbjct: 432 DREEDEEDAYERRKLERKLREKEAAYQ-----ERLKNWE--IRERKKTREYEKEAEREEE 484
Query: 595 HVREKVREETNTRSF 609
RE +E + F
Sbjct: 485 RRREMAKEAKRLKEF 499
Score = 62.8 bits (151), Expect = 9e-10
Identities = 50/213 (23%), Positives = 97/213 (45%), Gaps = 15/213 (7%)
Query: 347 RGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQG 406
+G E++R+ + R + E +R + E +R +++ + ERE++R ++
Sbjct: 295 KGKKEKERQ--EIEKERRERERERERERERREREREREREREREKEKERERERERDRDRD 352
Query: 407 RRAWAAQVEERRGRRGRE---------EREAARRRQRQYERSEERRRELAERQGLLRRER 457
R + +R R R+ +R +R + R ER ER RE ER+ RER
Sbjct: 353 RTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERE-RERERERERER 411
Query: 458 AERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKR 517
RE + +++ + REE ++ ER + R+ R + AA ++ + +++ K+
Sbjct: 412 EREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKK 471
Query: 518 ELSRAERARHEALLQGRTRQQRQEREGLRSSLE 550
+ A E + R R+ +E + L+ LE
Sbjct: 472 TREYEKEAERE---EERRREMAKEAKRLKEFLE 501
Score = 60.8 bits (146), Expect = 4e-09
Identities = 74/302 (24%), Positives = 116/302 (38%), Gaps = 38/302 (12%)
Query: 337 VRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREE 396
+ + R ER ER+R+ R +E E+ + R + R E
Sbjct: 305 IEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRE 364
Query: 397 REKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRRE---------- 445
R++ R E+ + R R RE ERE R R+R+ ER ER RE
Sbjct: 365 RDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERERERE 424
Query: 446 ---------------LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERA 490
ER+ L R+ R + AA ++RL+ + + K RE ++ ER
Sbjct: 425 REKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTRE--YEKEAERE 482
Query: 491 EQIRRERAQRAARAKQ--------RQEGQLQREKRELSRAERARHEALLQGRTR-QQRQE 541
E+ RRE A+ A R K+ R + + R R E R R ++++E
Sbjct: 483 EERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEE 542
Query: 542 REGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVR 601
E +R L A G + E + ++ ER Q ++ E + RE+
Sbjct: 543 LEEIRQRLLAE-GHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPM 601
Query: 602 EE 603
EE
Sbjct: 602 EE 603
Score = 59.7 bits (143), Expect = 8e-09
Identities = 51/189 (26%), Positives = 84/189 (44%), Gaps = 12/189 (6%)
Query: 440 EERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE--EGLQEGRERAEQIRRER 497
EE +R+L R E + D +KL++E+ K++E E +E RER + RER
Sbjct: 270 EEDKRDLISR---------EISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERER 320
Query: 498 AQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEAS-LGRA 556
+R ++ +E + ++EK ER R + R R + +ER+ R +S +
Sbjct: 321 ERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKD 380
Query: 557 QENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREA 616
+ + R+ ER + RER E R R RE+ RE+ R + +A
Sbjct: 381 RSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDA 440
Query: 617 QLHASLDRK 625
L+RK
Sbjct: 441 YERRKLERK 449
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/206 (24%), Positives = 89/206 (43%), Gaps = 45/206 (21%)
Query: 413 QVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQ 472
++EE +G++ +E +E + R+ ER ER RE RER ER +R R+ ++
Sbjct: 290 KLEEEKGKKEKERQEIEKERR---ERERERERE---------RERREREREREREREREK 337
Query: 473 EQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQ 532
E+ ++RE R+R ++ R+R + R + R+ + + R SR +
Sbjct: 338 EKE-RERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREK--------- 387
Query: 533 GRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARA 592
R R++ +ERE R+ ER + RER E R R
Sbjct: 388 SRDRERERERE-----------------------RERERERERERERERERERERERERE 424
Query: 593 SFHVREKVREETNTRSFDRMVREAQL 618
+++ REE +++R E +L
Sbjct: 425 REKDKKRDREEDEEDAYERRKLERKL 450
Score = 55.5 bits (132), Expect = 1e-07
Identities = 53/210 (25%), Positives = 91/210 (43%), Gaps = 33/210 (15%)
Query: 363 RHQEELLLLEQRAAAHGQWELQRVHAK-QRREREEREK----QRALEQGRRAWAAQVEER 417
R +E E+ + E +R K ++R+REE E+ +R LE+ R A +ER
Sbjct: 401 REREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQER 460
Query: 418 RGRRGREEREAARRRQRQYERSEERRRELAERQGLLR----------------------- 454
ER+ R +++ ER EERRRE+A+ L+
Sbjct: 461 LKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQK 520
Query: 455 --RERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQ---RQE 509
R+R + ++R RK ++E+ + R+ L EG + + Q A R +Q +QE
Sbjct: 521 RLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQE 580
Query: 510 GQLQREKRELSRAERARHEALLQGRTRQQR 539
+ + E+ E E R E + + +Q+
Sbjct: 581 PESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
Score = 54.7 bits (130), Expect = 3e-07
Identities = 47/186 (25%), Positives = 82/186 (44%), Gaps = 12/186 (6%)
Query: 434 RQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQI 493
R+ + + ++L E +G +ER E +E R R+ ++E+ ++RE + RER +
Sbjct: 279 REISKFRDTHKKLEEEKGKKEKERQE-IEKERRERERERERERERREREREREREREREK 337
Query: 494 RRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRS-SLEAS 552
+ER +E + R++ +R R + R R++ +R RS S E S
Sbjct: 338 EKER---------ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKS 388
Query: 553 LGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREET-NTRSFDR 611
R +E R+ ER + RER E R + RE+ E+ R +R
Sbjct: 389 RDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLER 448
Query: 612 MVREAQ 617
+RE +
Sbjct: 449 KLREKE 454
Score = 34.7 bits (78), Expect = 0.27
Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 11/85 (12%)
Query: 351 ERDRKIAALMLARHQEELLLLEQRAAAHGQ----WELQRVHAKQRREREEREKQRALEQG 406
ERDRK R +EEL + QR A G ELQR+ + R R+ + KQ +
Sbjct: 533 ERDRK-------REKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEE 585
Query: 407 RRAWAAQVEERRGRRGREEREAARR 431
+ EE+R EE E ++
Sbjct: 586 EEEEKQEKEEKREEPMEEEEEPEQK 610
>gi|219803769 trichoplein [Homo sapiens]
Length = 498
Score = 74.3 bits (181), Expect = 3e-13
Identities = 89/332 (26%), Positives = 145/332 (43%), Gaps = 57/332 (17%)
Query: 316 RSFSLGDLSHSPQTA--------QHVERIVRQVRAERGLRGVPERDRKIAALM------L 361
R F + D+ S Q + + R+ E R + R K+ LM L
Sbjct: 39 RYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLL 98
Query: 362 ARHQEELLL---LEQRAAAHGQWELQRVHAKQRREREE--------------REKQRALE 404
AR EEL L L++R +L+ +QR+ E RE + L
Sbjct: 99 ARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLH 158
Query: 405 QGR--RAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAA 462
Q +W Q EE++ + E+E +R + +YER+ RRE ER + ER
Sbjct: 159 QKHVVNSWEMQKEEKKQQEATAEQEN-KRYENEYERA---RREALERM----KAEEERRQ 210
Query: 463 REDRLRK---LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKREL 519
ED+L+ LQQ + LK +E + ++ E + ++R + ++R++ + R+K EL
Sbjct: 211 LEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAEL 270
Query: 520 SRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-HLA-----------IGR 567
R R ++ A L RT+Q ++E E R L+A L + E+ HLA + +
Sbjct: 271 GRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQ 330
Query: 568 KLERSEQLTRERRSALES-ARSTARASFHVRE 598
+E QL R R + L+ R A+ + RE
Sbjct: 331 AIEEQLQLERAREAELQMLLREEAKEMWEKRE 362
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/256 (27%), Positives = 123/256 (48%), Gaps = 27/256 (10%)
Query: 339 QVRAERGLRGVPE-RDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 397
+++AE L+ + E + +++ A L + QE LL +QR WEL+R+ ++++ R
Sbjct: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLL--KQR------WELERLEEERKQMEAFR 265
Query: 398 EKQRALEQGRRAWAAQVEERRGRRGREEREAARR-RQRQYERSEERRR-ELAERQGLLRR 455
+K R + AQ+ RR ++ +EE EA RR Q E+ +E +R LA R+ ++
Sbjct: 266 QKAELGRFLRHQYNAQLS-RRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMAD 324
Query: 456 ERAERAAREDRL---RKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQL 512
+ A E++L R + E + REE + +R + RER+ R + G+
Sbjct: 325 VAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQ 384
Query: 513 QREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE---ASLGRAQENYEHLAIGRKL 569
Q+ + ++ + RA+ E+L + RE L +LE R +E E L RK
Sbjct: 385 QQIQEKIEQNRRAQEESL---------KHREQLIRNLEEVRELARREKEESEKLKSARKQ 435
Query: 570 ERSEQLTRERRSALES 585
E Q+ R A E+
Sbjct: 436 ELEAQVAERRLQAWEA 451
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/215 (26%), Positives = 98/215 (45%), Gaps = 30/215 (13%)
Query: 325 HSPQTAQHVERIVRQVRAERG-LRGVPERDRKIAALMLARHQ-------------EELLL 370
++ Q ++ ++I ++ A+R L+ + E++ + L LAR + EE L
Sbjct: 278 YNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337
Query: 371 LEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR 430
LE+ A Q L R AK+ E+ E E R R ++V R ++ +E+ E R
Sbjct: 338 LERAREAELQM-LLREEAKEMWEKREAEWARE-RSARDRLMSEVLTGRQQQIQEKIEQNR 395
Query: 431 RRQRQ-YERSEERRRELAERQGLLRRERAE----RAAREDRLRKLQQEQNLKQREEGLQE 485
R Q + + E+ R L E + L RRE+ E ++AR+ L E+ L+ E
Sbjct: 396 RAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWE----- 450
Query: 486 GRERAEQIRRERAQRAARAKQRQEGQLQREKRELS 520
A+Q E + A R +Q + LQ+E ++
Sbjct: 451 ----ADQQEEEEEEEARRVEQLSDALLQQEAETMA 481
Score = 37.0 bits (84), Expect = 0.055
Identities = 39/220 (17%), Positives = 98/220 (44%), Gaps = 19/220 (8%)
Query: 410 WAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRK 469
W +Q +R ++ +RE R ++Q+E++ R +++ + E + + + + +
Sbjct: 10 WCSQ--QRLNQQLARQREQEARLRQQWEQNSRYFR-MSDICSSKQAEWSSKTSYQRSMHA 66
Query: 470 LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR-------QEGQLQREKRELSRA 522
Q+E+ +++ L+ RE+ Q+ +E AR + QE +++ + +L A
Sbjct: 67 YQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSA 126
Query: 523 ERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSA 582
+ + + + + + ++ +E L + +H+ ++++ E+ +E +
Sbjct: 127 KEEQRKLIAEQLLYEHWKKNNPKLREMELDL-----HQKHVVNSWEMQKEEKKQQEATAE 181
Query: 583 LESAR---STARASFHVREKVREETNTRSF-DRMVREAQL 618
E+ R RA E+++ E R D++ EA L
Sbjct: 182 QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALL 221
Score = 35.8 bits (81), Expect = 0.12
Identities = 36/122 (29%), Positives = 55/122 (45%), Gaps = 19/122 (15%)
Query: 352 RDRKIAALMLARHQEELLLLEQRAAAHGQW---------ELQRVHAKQRREREEREKQRA 402
RDR ++ ++ R Q+ +EQ A + L+ V RRE+EE EK ++
Sbjct: 372 RDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKS 431
Query: 403 LEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAA 462
++ AQV ERR +A Q++ E EE RR LL++E AE A
Sbjct: 432 AR--KQELEAQVAERR-------LQAWEADQQEEEEEEEARRVEQLSDALLQQE-AETMA 481
Query: 463 RE 464
+
Sbjct: 482 EQ 483
>gi|14150056 trichoplein [Homo sapiens]
Length = 498
Score = 74.3 bits (181), Expect = 3e-13
Identities = 89/332 (26%), Positives = 145/332 (43%), Gaps = 57/332 (17%)
Query: 316 RSFSLGDLSHSPQTA--------QHVERIVRQVRAERGLRGVPERDRKIAALM------L 361
R F + D+ S Q + + R+ E R + R K+ LM L
Sbjct: 39 RYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLL 98
Query: 362 ARHQEELLL---LEQRAAAHGQWELQRVHAKQRREREE--------------REKQRALE 404
AR EEL L L++R +L+ +QR+ E RE + L
Sbjct: 99 ARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLH 158
Query: 405 QGR--RAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAA 462
Q +W Q EE++ + E+E +R + +YER+ RRE ER + ER
Sbjct: 159 QKHVVNSWEMQKEEKKQQEATAEQEN-KRYENEYERA---RREALERM----KAEEERRQ 210
Query: 463 REDRLRK---LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKREL 519
ED+L+ LQQ + LK +E + ++ E + ++R + ++R++ + R+K EL
Sbjct: 211 LEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAEL 270
Query: 520 SRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-HLA-----------IGR 567
R R ++ A L RT+Q ++E E R L+A L + E+ HLA + +
Sbjct: 271 GRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQ 330
Query: 568 KLERSEQLTRERRSALES-ARSTARASFHVRE 598
+E QL R R + L+ R A+ + RE
Sbjct: 331 AIEEQLQLERAREAELQMLLREEAKEMWEKRE 362
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/256 (27%), Positives = 123/256 (48%), Gaps = 27/256 (10%)
Query: 339 QVRAERGLRGVPE-RDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 397
+++AE L+ + E + +++ A L + QE LL +QR WEL+R+ ++++ R
Sbjct: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLL--KQR------WELERLEEERKQMEAFR 265
Query: 398 EKQRALEQGRRAWAAQVEERRGRRGREEREAARR-RQRQYERSEERRR-ELAERQGLLRR 455
+K R + AQ+ RR ++ +EE EA RR Q E+ +E +R LA R+ ++
Sbjct: 266 QKAELGRFLRHQYNAQLS-RRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMAD 324
Query: 456 ERAERAAREDRL---RKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQL 512
+ A E++L R + E + REE + +R + RER+ R + G+
Sbjct: 325 VAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQ 384
Query: 513 QREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE---ASLGRAQENYEHLAIGRKL 569
Q+ + ++ + RA+ E+L + RE L +LE R +E E L RK
Sbjct: 385 QQIQEKIEQNRRAQEESL---------KHREQLIRNLEEVRELARREKEESEKLKSARKQ 435
Query: 570 ERSEQLTRERRSALES 585
E Q+ R A E+
Sbjct: 436 ELEAQVAERRLQAWEA 451
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/215 (26%), Positives = 98/215 (45%), Gaps = 30/215 (13%)
Query: 325 HSPQTAQHVERIVRQVRAERG-LRGVPERDRKIAALMLARHQ-------------EELLL 370
++ Q ++ ++I ++ A+R L+ + E++ + L LAR + EE L
Sbjct: 278 YNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337
Query: 371 LEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR 430
LE+ A Q L R AK+ E+ E E R R ++V R ++ +E+ E R
Sbjct: 338 LERAREAELQM-LLREEAKEMWEKREAEWARE-RSARDRLMSEVLTGRQQQIQEKIEQNR 395
Query: 431 RRQRQ-YERSEERRRELAERQGLLRRERAE----RAAREDRLRKLQQEQNLKQREEGLQE 485
R Q + + E+ R L E + L RRE+ E ++AR+ L E+ L+ E
Sbjct: 396 RAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWE----- 450
Query: 486 GRERAEQIRRERAQRAARAKQRQEGQLQREKRELS 520
A+Q E + A R +Q + LQ+E ++
Sbjct: 451 ----ADQQEEEEEEEARRVEQLSDALLQQEAETMA 481
Score = 37.0 bits (84), Expect = 0.055
Identities = 39/220 (17%), Positives = 98/220 (44%), Gaps = 19/220 (8%)
Query: 410 WAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRK 469
W +Q +R ++ +RE R ++Q+E++ R +++ + E + + + + +
Sbjct: 10 WCSQ--QRLNQQLARQREQEARLRQQWEQNSRYFR-MSDICSSKQAEWSSKTSYQRSMHA 66
Query: 470 LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR-------QEGQLQREKRELSRA 522
Q+E+ +++ L+ RE+ Q+ +E AR + QE +++ + +L A
Sbjct: 67 YQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSA 126
Query: 523 ERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSA 582
+ + + + + + ++ +E L + +H+ ++++ E+ +E +
Sbjct: 127 KEEQRKLIAEQLLYEHWKKNNPKLREMELDL-----HQKHVVNSWEMQKEEKKQQEATAE 181
Query: 583 LESAR---STARASFHVREKVREETNTRSF-DRMVREAQL 618
E+ R RA E+++ E R D++ EA L
Sbjct: 182 QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALL 221
Score = 35.8 bits (81), Expect = 0.12
Identities = 36/122 (29%), Positives = 55/122 (45%), Gaps = 19/122 (15%)
Query: 352 RDRKIAALMLARHQEELLLLEQRAAAHGQW---------ELQRVHAKQRREREEREKQRA 402
RDR ++ ++ R Q+ +EQ A + L+ V RRE+EE EK ++
Sbjct: 372 RDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKS 431
Query: 403 LEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAA 462
++ AQV ERR +A Q++ E EE RR LL++E AE A
Sbjct: 432 AR--KQELEAQVAERR-------LQAWEADQQEEEEEEEARRVEQLSDALLQQE-AETMA 481
Query: 463 RE 464
+
Sbjct: 482 EQ 483
>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
[Homo sapiens]
Length = 213
Score = 72.8 bits (177), Expect = 9e-13
Identities = 53/194 (27%), Positives = 87/194 (44%), Gaps = 5/194 (2%)
Query: 389 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA- 447
++RR +RE+ RA E ++ + +R R ER+ R R++Q +R ER+RE
Sbjct: 21 RERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRERER 80
Query: 448 --ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 505
+RQ RER + + ++ Q K+RE RER +Q R ++ R
Sbjct: 81 DRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDRET 140
Query: 506 QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAI 565
R+ + +RE R + E + R R++++ERE R + E E
Sbjct: 141 DRERERQAERERETGRERKT--EDRHRERERERKRERERKRETKERERHTDMERERQRET 198
Query: 566 GRKLERSEQLTRER 579
RK +R + RER
Sbjct: 199 DRKRDRQRESERER 212
Score = 63.9 bits (154), Expect = 4e-10
Identities = 57/214 (26%), Positives = 92/214 (42%), Gaps = 13/214 (6%)
Query: 332 HVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQR 391
H E + ER ERDR + RH E +++ E R +++
Sbjct: 11 HTETETMDRQRERRRETDRERDRAKESKTEDRHSER----DRQRDRERNRERDRDREREK 66
Query: 392 REREEREKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRRELAERQ 450
+ E E+QR E+ R +R R R+ ERE R + ER +++ RE+ ER
Sbjct: 67 QTDREGERQRERERDRD------RQRETERERDKERETDRHTETDRERQKQKEREM-ERV 119
Query: 451 GLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRER-AEQIRRERAQRAARAKQRQE 509
RE+ + RE + + + +Q E + GRER E RER + R ++R+
Sbjct: 120 RDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKR 179
Query: 510 GQLQREKRELSRAERARHEALLQGRTRQQRQERE 543
+RE+ ER R + R R+ +ER+
Sbjct: 180 ETKERERHTDMERERQRETDRKRDRQRESERERD 213
Score = 62.8 bits (151), Expect = 9e-10
Identities = 53/207 (25%), Positives = 87/207 (42%), Gaps = 23/207 (11%)
Query: 422 GREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREE 481
GR RQ ER E RE R+RA+ + EDR + ++++ ++R
Sbjct: 7 GRHTHTETETMDRQRERRRETDRE---------RDRAKESKTEDRHSERDRQRD-RERNR 56
Query: 482 GLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQE 541
RER +Q RE ++ R + R + Q + E+ E RH + R +Q+ +E
Sbjct: 57 ERDRDREREKQTDREGERQRERERDR-DRQRETERERDKERETDRHTETDRERQKQKERE 115
Query: 542 REGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTAR---ASFHVRE 598
E +R +E + +GR+ + + RER E R T R RE
Sbjct: 116 MERVRD---------REREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRE 166
Query: 599 KVREETNTRSFDRMVREAQLHASLDRK 625
+ RE R R +E + H ++R+
Sbjct: 167 RERERKRERERKRETKERERHTDMERE 193
Score = 55.5 bits (132), Expect = 1e-07
Identities = 63/236 (26%), Positives = 96/236 (40%), Gaps = 40/236 (16%)
Query: 387 HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRREL 446
H E +R+++R E R +R E+R + R RQR ER+ ER R+
Sbjct: 9 HTHTETETMDRQRERRRETDRE------RDRAKESKTEDRHSERDRQRDRERNRERDRD- 61
Query: 447 AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRER--AQRAARA 504
RER ++ RE +QRE + R+R + RER + R
Sbjct: 62 --------REREKQTDREGE----------RQRER--ERDRDRQRETERERDKERETDRH 101
Query: 505 KQRQEGQLQREKRELSRA-ERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHL 563
+ + ++++RE+ R +R R + GR RQ +E + R R E
Sbjct: 102 TETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERE-------RQAERERET 154
Query: 564 AIGRKLE-RSEQLTRERRSALESARSTARASFHV-REKVREETNTRSFDRMVREAQ 617
RK E R + RER+ E R T H E+ R+ R DR RE++
Sbjct: 155 GRERKTEDRHRERERERKRERERKRETKERERHTDMERERQRETDRKRDRQ-RESE 209
Score = 30.8 bits (68), Expect = 3.9
Identities = 28/114 (24%), Positives = 43/114 (37%), Gaps = 11/114 (9%)
Query: 515 EKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQ 574
E + R E + + R R++ +RE R+ + R E R +R +
Sbjct: 2 ESKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSE--------RDRQRDRE 53
Query: 575 LTRERRSALESARSTARASFHVREKVREETNTRSFDR---MVREAQLHASLDRK 625
RER E + T R RE+ R+ R +R RE H DR+
Sbjct: 54 RNRERDRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRE 107
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 72.4 bits (176), Expect = 1e-12
Identities = 58/198 (29%), Positives = 100/198 (50%), Gaps = 13/198 (6%)
Query: 361 LARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGR 420
L R +L Q + + E+QR ++++ ++E E++R + R ++E R
Sbjct: 120 LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERL--ERERMERERLERERLE 177
Query: 421 RGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE 480
R R ERE + Q + ER E R+E ERQ R ER ER R++RL + +QE+ ++R
Sbjct: 178 RERLERERLEQEQLERERQERERQERLERQE--RLERQERLERQERLDRERQERQERERL 235
Query: 481 EGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ 540
E L+ RER E+ R+E+ +R++ + +RE+R S A A E L
Sbjct: 236 ERLE--RERQERERQEQL-------EREQLEWERERRISSAAAPASVETPLNSVLGDSSA 286
Query: 541 EREGLRSSLEASLGRAQE 558
GL+++ + + +Q+
Sbjct: 287 SEPGLQAASQPAETPSQQ 304
Score = 53.9 bits (128), Expect = 4e-07
Identities = 47/151 (31%), Positives = 75/151 (49%), Gaps = 20/151 (13%)
Query: 471 QQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEAL 530
Q+E +++R+ LQE ++R +++ RER +R ++R L+RE+ E R ER R E
Sbjct: 137 QEELEIQRRQ--LQE-QQRQKELERERLERERMERER----LERERLERERLERERLEQE 189
Query: 531 LQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTA 590
R RQ+R+ +E L E E L +LER E+L RER+ E R
Sbjct: 190 QLERERQERERQERL------------ERQERLERQERLERQERLDRERQERQERER-LE 236
Query: 591 RASFHVREKVREETNTRSFDRMVREAQLHAS 621
R +E+ R+E R RE ++ ++
Sbjct: 237 RLERERQERERQEQLEREQLEWERERRISSA 267
Score = 52.0 bits (123), Expect = 2e-06
Identities = 50/165 (30%), Positives = 78/165 (47%), Gaps = 18/165 (10%)
Query: 464 EDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR------QEGQLQREKR 517
E + R+LQ++Q R++ L+ R E++ RER +R ++R ++ QL+RE++
Sbjct: 141 EIQRRQLQEQQ----RQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
Query: 518 ELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGR-KLERSEQLT 576
E R ER + L+ + R +RQE R E + +E E L R + ER EQL
Sbjct: 197 ERERQERLERQERLERQERLERQE----RLDRERQERQERERLERLERERQERERQEQLE 252
Query: 577 RERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHAS 621
RE+ LE R +S V N+ D E L A+
Sbjct: 253 REQ---LEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAA 294
Score = 38.1 bits (87), Expect = 0.024
Identities = 35/117 (29%), Positives = 56/117 (47%), Gaps = 5/117 (4%)
Query: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 387
Q + +ER ++ ER R ER+R + E+ L +R Q L+R
Sbjct: 151 QRQKELER--ERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQE 208
Query: 388 AKQRREREEREKQRALEQGRRAWAAQVEE-RRGRRGREEREAARRRQRQYERSEERR 443
+R+ER ER+++ E+ R ++E R R+ RE +E R Q ++ER ERR
Sbjct: 209 RLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWER--ERR 263
Score = 33.9 bits (76), Expect = 0.46
Identities = 25/99 (25%), Positives = 43/99 (43%), Gaps = 14/99 (14%)
Query: 152 EAYEAERRAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAA-AASAPSAGSSSSCSSAS 210
E E ER+ + +Q + ER+++ E +RR+ + +PA+ + S+ S +AS
Sbjct: 236 ERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAAS 295
Query: 211 LPA-------------SPAPRAARKASPSPSSARTQPPP 236
PA +P P P+ +S PPP
Sbjct: 296 QPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPP 334
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.124 0.339
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,106,283
Number of Sequences: 37866
Number of extensions: 1257611
Number of successful extensions: 40552
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 760
Number of HSP's successfully gapped in prelim test: 1727
Number of HSP's that attempted gapping in prelim test: 14675
Number of HSP's gapped (non-prelim): 12136
length of query: 625
length of database: 18,247,518
effective HSP length: 108
effective length of query: 517
effective length of database: 14,157,990
effective search space: 7319680830
effective search space used: 7319680830
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.