Search of human proteins with 239754976

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239754976 PREDICTED: IQ motif and ankyrin repeat
domain-containing protein LOC642574 [Homo sapiens]
         (484 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239754976 PREDICTED: IQ motif and ankyrin repeat domain-conta...   962   0.0  
gi|239743649 PREDICTED: IQ motif and ankyrin repeat domain-conta...   903   0.0  
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        59   8e-09
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso...    59   1e-08
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof...    59   1e-08
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         57   5e-08
gi|56676397 ankyrin repeat domain 11 [Homo sapiens]                    57   5e-08
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         56   6e-08
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         56   6e-08
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         56   6e-08
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         56   6e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        54   2e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        54   2e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         54   2e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         54   2e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         54   2e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         54   2e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         54   2e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         54   2e-07
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        53   5e-07
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         53   5e-07
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         53   5e-07
gi|67906195 ankyrin repeat and sterile alpha motif domain contai...    53   5e-07
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho...    53   5e-07
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...    53   7e-07
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...    53   7e-07
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                    52   9e-07
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    52   1e-06
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           51   2e-06
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           51   2e-06

>gi|239754976 PREDICTED: IQ motif and ankyrin repeat
           domain-containing protein LOC642574 [Homo sapiens]
          Length = 484

 Score =  962 bits (2488), Expect = 0.0
 Identities = 484/484 (100%), Positives = 484/484 (100%)

Query: 1   MQEGPSAFREGCPAGDSTPSSPFLGAPELRARRGSQDPRRRPAEDRAARAIQGAFRQLRA 60
           MQEGPSAFREGCPAGDSTPSSPFLGAPELRARRGSQDPRRRPAEDRAARAIQGAFRQLRA
Sbjct: 1   MQEGPSAFREGCPAGDSTPSSPFLGAPELRARRGSQDPRRRPAEDRAARAIQGAFRQLRA 60

Query: 61  RRELARRREERREYLEQMETPQKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGN 120
           RRELARRREERREYLEQMETPQKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGN
Sbjct: 61  RRELARRREERREYLEQMETPQKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGN 120

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 180
           TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV
Sbjct: 121 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 180

Query: 181 YAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTL 240
           YAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTL
Sbjct: 181 YAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTL 240

Query: 241 KVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQ 300
           KVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQ
Sbjct: 241 KVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQ 300

Query: 301 EAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVID 360
           EAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVID
Sbjct: 301 EAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVID 360

Query: 361 PLGQAATFLRYQDTNYVDTVNPEPLRPERMWLALLGALRYGKPLVFDLREEDLFPVVQRQ 420
           PLGQAATFLRYQDTNYVDTVNPEPLRPERMWLALLGALRYGKPLVFDLREEDLFPVVQRQ
Sbjct: 361 PLGQAATFLRYQDTNYVDTVNPEPLRPERMWLALLGALRYGKPLVFDLREEDLFPVVQRQ 420

Query: 421 LEAVQERYLSLLRPTDGPEYSPTQFQEQRLEHFRLFFVTKVQWPPAEQLQVLLPVRVQLP 480
           LEAVQERYLSLLRPTDGPEYSPTQFQEQRLEHFRLFFVTKVQWPPAEQLQVLLPVRVQLP
Sbjct: 421 LEAVQERYLSLLRPTDGPEYSPTQFQEQRLEHFRLFFVTKVQWPPAEQLQVLLPVRVQLP 480

Query: 481 GTGL 484
           GTGL
Sbjct: 481 GTGL 484


>gi|239743649 PREDICTED: IQ motif and ankyrin repeat
           domain-containing protein LOC642574 [Homo sapiens]
          Length = 580

 Score =  903 bits (2333), Expect = 0.0
 Identities = 480/580 (82%), Positives = 480/580 (82%), Gaps = 96/580 (16%)

Query: 1   MQEGPSAFREGCPAGDSTPSSPFLGAPELRARRGSQDPRRR------------------- 41
           MQEGPSAFREGCPAGDSTPSSPFLGAPELRARRGSQDPRRR                   
Sbjct: 1   MQEGPSAFREGCPAGDSTPSSPFLGAPELRARRGSQDPRRRGAGEVPADLGPLRVPGSRA 60

Query: 42  ----------------------PAEDRAARAIQGAFRQLRARRELARRREERREYL---- 75
                                 PAEDRAARAIQGAFRQLRARRELARRREERREYL    
Sbjct: 61  ASSCGLCGREPRLGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQME 120

Query: 76  ----------------------EQMETPQ-----------------------------KE 84
                                 EQ E  Q                             KE
Sbjct: 121 TPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKE 180

Query: 85  VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS 144
           VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS
Sbjct: 181 VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS 240

Query: 145 PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW 204
           PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW
Sbjct: 241 PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW 300

Query: 205 DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS 264
           DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS
Sbjct: 301 DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS 360

Query: 265 RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 324
           RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE
Sbjct: 361 RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 420

Query: 325 EEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQDTNYVDTVNPEP 384
           EEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQDTNYVDTVNPEP
Sbjct: 421 EEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQDTNYVDTVNPEP 480

Query: 385 LRPERMWLALLGALRYGKPLVFDLREEDLFPVVQRQLEAVQERYLSLLRPTDGPEYSPTQ 444
           LRPE MWLALLGALRYGKPLVFDLREEDLFPVVQRQLEAVQERYLSLLRPTDGPEYSPTQ
Sbjct: 481 LRPETMWLALLGALRYGKPLVFDLREEDLFPVVQRQLEAVQERYLSLLRPTDGPEYSPTQ 540

Query: 445 FQEQRLEHFRLFFVTKVQWPPAEQLQVLLPVRVQLPGTGL 484
           FQEQRLEHFRLFFVTKVQWPPAEQLQVLLPVRVQLPGTGL
Sbjct: 541 FQEQRLEHFRLFFVTKVQWPPAEQLQVLLPVRVQLPGTGL 580


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 53/167 (31%), Positives = 73/167 (43%), Gaps = 5/167 (2%)

Query: 28  ELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRE--LARRREERREYLEQMETPQKEV 85
           E + +  S   RR  + DR  +A   A   LRA R   L +  +  R  ++     Q  +
Sbjct: 21  EQKEKEESNRKRRNRSRDRKKKA-DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGL 79

Query: 86  EQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASP 145
             L      GH +      L  +  + E     GNT L  AA  GQ   ++     GA+ 
Sbjct: 80  NGLHLASKEGHVKM--VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 137

Query: 146 NSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA 192
           N++   G TPLY AA   HL  V+ LL+ GA+  V  EDG TP  VA
Sbjct: 138 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 184



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 40/109 (36%), Positives = 51/109 (46%), Gaps = 2/109 (1%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GH E   A  L  + A   C    G TPL  AA  G+    +L  E  A PN+ G  G T
Sbjct: 547 GHVETVLA--LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 604

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRS 203
           PL+ A    +L  V++LL  G  P   A +G TP  +A+    V V RS
Sbjct: 605 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 653



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 30/73 (41%), Positives = 38/73 (52%)

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 180
           TPL  AA  G     ++  + GA PNS+   G TPL+ A    H+  +E+LLK GA    
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432

Query: 181 YAEDGSTPERVAS 193
             E G TP  VAS
Sbjct: 433 VTESGLTPLHVAS 445



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 30/82 (36%), Positives = 43/82 (52%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A+  G    ++   +  A  N+K   G +PL++AA  GH   V +LLK GA P
Sbjct: 734 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 793

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
              + DG+TP  +A     +SV
Sbjct: 794 NEVSSDGTTPLAIAKRLGYISV 815



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 34/99 (34%), Positives = 45/99 (45%), Gaps = 2/99 (2%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GH E   A+ L +  A    +     TPL  AA  G    ++L  E  A+PN     G T
Sbjct: 481 GHTEV--AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 538

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
           PL+ AA  GH+  V  LL+  A      + G TP  VA+
Sbjct: 539 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 577



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 9/110 (8%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A        ++L  + GAS ++    G TPL+ A+F GHL  V+ LL+ GA P
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463

Query: 179 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQ 228
            V      TP  +A+        R+    + + +LQN +A+   +A++ Q
Sbjct: 464 NVSNVKVETPLHMAA--------RAGHTEVAKYLLQN-KAKVNAKAKDDQ 504



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 35/125 (28%), Positives = 59/125 (47%), Gaps = 5/125 (4%)

Query: 96  HDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTP 155
           ++    A+ L  R A        G TPL  A+  G  + ++L  + GA   +K     TP
Sbjct: 249 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 308

Query: 156 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVLRSWDLSLTEA 211
           L+ AA  GH+   E+LL  GA  +   ++G +P  +A+    LD  V +L  +D  + + 
Sbjct: 309 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD-CVRLLLQYDAEIDDI 367

Query: 212 MLQNM 216
            L ++
Sbjct: 368 TLDHL 372



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 32/92 (34%), Positives = 39/92 (42%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           AR L +    A  E   G TPL  AA  G    + L     A+ N     G TPL+  A 
Sbjct: 651 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 710

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            GH+   +VL+K G         G TP  VAS
Sbjct: 711 EGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 4/103 (3%)

Query: 103 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 162
           + L +R A     +    TPL  AA  G     +   +  A  N+K     TPL+ AA  
Sbjct: 454 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 513

Query: 163 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVL 201
           GH   V++LL+  A+P +    G TP  +A+    ++TV+++L
Sbjct: 514 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 556



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 26/75 (34%), Positives = 35/75 (46%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A+  G    ++   + GASPN       TPL+ AA  GH    + LL+  A  
Sbjct: 437 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 496

Query: 179 RVYAEDGSTPERVAS 193
              A+D  TP   A+
Sbjct: 497 NAKAKDDQTPLHCAA 511



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 27/82 (32%), Positives = 39/82 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA   Q    +   + G S N++   G TPL+ AA  GH   V +LL   A+ 
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
            +  + G TP  + + +  V V
Sbjct: 695 NLGNKSGLTPLHLVAQEGHVPV 716



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 27/74 (36%), Positives = 35/74 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G+TPL  AA  G    +    E  AS       G TPL+ AA  G +   E+LL+  A P
Sbjct: 536 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 595

Query: 179 RVYAEDGSTPERVA 192
               ++G TP  VA
Sbjct: 596 NAAGKNGLTPLHVA 609



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 30/91 (32%), Positives = 42/91 (46%)

Query: 103 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 162
           R L  R A  E +     TPL  AA  G     ++  + GA   +K   G +P++ AA G
Sbjct: 289 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 348

Query: 163 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            HL  V +LL+  A+      D  TP  VA+
Sbjct: 349 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 379



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 38/126 (30%), Positives = 53/126 (42%), Gaps = 3/126 (2%)

Query: 77  QMETPQK-EVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAI 135
           Q+ET  K E+  L      GH    E   L    A  + +   G +P+  AA G     +
Sbjct: 297 QIETKTKDELTPLHCAARNGHVRISEI--LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 354

Query: 136 QLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLD 195
           +L  +  A  +       TPL+ AA  GH    +VLL  GA P   A +G TP  +A   
Sbjct: 355 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 414

Query: 196 TVVSVL 201
             V V+
Sbjct: 415 NHVRVM 420



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 20/53 (37%), Positives = 29/53 (54%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVL 171
           G +PL +AA  G    + L  + GASPN   + G TPL  A   G+++  +VL
Sbjct: 767 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 27/75 (36%), Positives = 34/75 (45%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA        QL    GAS N     G TPL+ A+  G++  V +LL  GA  
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 298

Query: 179 RVYAEDGSTPERVAS 193
               +D  TP   A+
Sbjct: 299 ETKTKDELTPLHCAA 313



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 27/92 (29%), Positives = 36/92 (39%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           A  L  R A        G TPL  A        ++L    G SP+S    G TPL+ AA 
Sbjct: 585 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 644

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
              +     LL+ G      +  G TP  +A+
Sbjct: 645 QNQVEVARSLLQYGGSANAESVQGVTPLHLAA 676



 Score = 29.6 bits (65), Expect = 6.4
 Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 2/86 (2%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           G DE    R L    A    +   G TPL  AA       ++   E GA+ N     G T
Sbjct: 122 GQDEV--VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 179

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRV 180
           PL  A   GH   V  L+  G   +V
Sbjct: 180 PLAVALQQGHENVVAHLINYGTKGKV 205



 Score = 29.3 bits (64), Expect = 8.4
 Identities = 17/50 (34%), Positives = 26/50 (52%)

Query: 144 SPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
           +P+     G TPL+ AA   +L   ++LL  GA      ++G TP  +AS
Sbjct: 231 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 280


>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
           isoform b [Homo sapiens]
          Length = 445

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 33/82 (40%), Positives = 46/82 (56%)

Query: 105 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 164
           L R+ A  EC+D +G TPL  AA  G+  ++ +    GA+ N +     TPL+ AA  GH
Sbjct: 92  LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH 151

Query: 165 LAAVEVLLKLGADPRVYAEDGS 186
              VE+LL  GADP +Y  + S
Sbjct: 152 TKCVELLLSSGADPDLYCNEDS 173



 Score = 36.2 bits (82), Expect = 0.068
 Identities = 21/59 (35%), Positives = 33/59 (55%)

Query: 135 IQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
           I+L    GA+   +  FG TPL+ AA  G L ++ +L+  GA+    A D +TP  +A+
Sbjct: 89  IKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAA 147



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 21/69 (30%), Positives = 29/69 (42%)

Query: 114 CEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLK 173
           C +     P+  AA  G    + L   L       G    +P+Y A FGGH   +E+LL+
Sbjct: 169 CNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLR 228

Query: 174 LGADPRVYA 182
            G  P   A
Sbjct: 229 NGYSPDAQA 237



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 20/59 (33%), Positives = 30/59 (50%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGAD 177
           G   L  AA+ G    +Q+  E GA PN+      TPL+ A   G +  + +LL+ GA+
Sbjct: 6   GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64



 Score = 33.1 bits (74), Expect = 0.58
 Identities = 24/74 (32%), Positives = 39/74 (52%), Gaps = 1/74 (1%)

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPN-SKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 179
           TPL  A   GQ   ++L  + GA+ N S    G   L++A+F  +   +++LL+ GA+  
Sbjct: 41  TPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 100

Query: 180 VYAEDGSTPERVAS 193
              + G TP  VA+
Sbjct: 101 CQDDFGITPLFVAA 114



 Score = 32.7 bits (73), Expect = 0.76
 Identities = 18/47 (38%), Positives = 27/47 (57%)

Query: 156 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR 202
           L+ AA  GH   V++LL+ GADP     + +TP  +A  +  + VLR
Sbjct: 10  LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLR 56


>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
           a [Homo sapiens]
          Length = 518

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 33/82 (40%), Positives = 46/82 (56%)

Query: 105 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 164
           L R+ A  EC+D +G TPL  AA  G+  ++ +    GA+ N +     TPL+ AA  GH
Sbjct: 165 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH 224

Query: 165 LAAVEVLLKLGADPRVYAEDGS 186
              VE+LL  GADP +Y  + S
Sbjct: 225 TKCVELLLSSGADPDLYCNEDS 246



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 3/103 (2%)

Query: 103 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPN---SKGAFGPTPLYRA 159
           R+L ++    +  D+ G  P+ EAA       +Q+     +S N    K   G   L+ A
Sbjct: 27  RKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLA 86

Query: 160 AFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR 202
           A  GH   V++LL+ GADP     + +TP  +A  +  + VLR
Sbjct: 87  ASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLR 129



 Score = 36.2 bits (82), Expect = 0.068
 Identities = 21/59 (35%), Positives = 33/59 (55%)

Query: 135 IQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
           I+L    GA+   +  FG TPL+ AA  G L ++ +L+  GA+    A D +TP  +A+
Sbjct: 162 IKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAA 220



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 21/69 (30%), Positives = 29/69 (42%)

Query: 114 CEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLK 173
           C +     P+  AA  G    + L   L       G    +P+Y A FGGH   +E+LL+
Sbjct: 242 CNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLR 301

Query: 174 LGADPRVYA 182
            G  P   A
Sbjct: 302 NGYSPDAQA 310



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 20/59 (33%), Positives = 30/59 (50%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGAD 177
           G   L  AA+ G    +Q+  E GA PN+      TPL+ A   G +  + +LL+ GA+
Sbjct: 79  GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 137



 Score = 33.1 bits (74), Expect = 0.58
 Identities = 24/74 (32%), Positives = 39/74 (52%), Gaps = 1/74 (1%)

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPN-SKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 179
           TPL  A   GQ   ++L  + GA+ N S    G   L++A+F  +   +++LL+ GA+  
Sbjct: 114 TPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 173

Query: 180 VYAEDGSTPERVAS 193
              + G TP  VA+
Sbjct: 174 CQDDFGITPLFVAA 187


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 42/110 (38%), Positives = 54/110 (49%), Gaps = 5/110 (4%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GH E      L +R A  +     GNT L  A+  GQ   +++    GA+ N++   G T
Sbjct: 85  GHVEV--VSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFT 142

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA---SLDTVVSVL 201
           PLY AA   HL  V+ LL  GA   +  EDG TP  VA     D VVS+L
Sbjct: 143 PLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 28/75 (37%), Positives = 39/75 (52%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA  G+     L  +  ASP++ G  G TPL+ AA   +     +LL  GA P
Sbjct: 565 GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624

Query: 179 RVYAEDGSTPERVAS 193
              A++G TP  +A+
Sbjct: 625 HAAAKNGYTPLHIAA 639



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 33/126 (26%), Positives = 52/126 (41%)

Query: 97  DEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPL 156
           D    A  L  + A  + +   G TPL      G    +    +  A  N+K   G TPL
Sbjct: 708 DRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPL 767

Query: 157 YRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNM 216
           ++AA  GH   + VLL+  A P     +G+T   +A     +SV+ +  +   E M    
Sbjct: 768 HQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTT 827

Query: 217 EAEQQR 222
             E+ +
Sbjct: 828 VTEKHK 833



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 32/96 (33%), Positives = 45/96 (46%)

Query: 98  EAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLY 157
           +A   R L +  A  E +     TPL  +A  G+   +Q   + GASPN+    G TPL+
Sbjct: 478 QAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLH 537

Query: 158 RAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            +A  GH      LL  GA   +  + G TP  VA+
Sbjct: 538 LSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAA 573



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 31/97 (31%), Positives = 48/97 (49%), Gaps = 1/97 (1%)

Query: 105 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 164
           LQ  V + +  + Y  T L  AA  G     ++  +  A+PN+K   G TPL+ A     
Sbjct: 354 LQHNVPVDDVTNDY-LTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNR 412

Query: 165 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 201
           +  +E+LLK GA  +   E G TP  VA+    V+++
Sbjct: 413 IKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 25/75 (33%), Positives = 35/75 (46%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TP+  AA  G    +      GASPN+    G T L+ AA  G    V  L++ GA  
Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 492

Query: 179 RVYAEDGSTPERVAS 193
              A+D  TP  +++
Sbjct: 493 EAKAKDDQTPLHISA 507



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 27/84 (32%), Positives = 39/84 (46%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A    +   ++L  + GAS  +    G TP++ AAF GH+  V  L+  GA P
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459

Query: 179 RVYAEDGSTPERVASLDTVVSVLR 202
                 G T   +A+      V+R
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVR 483



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 24/70 (34%), Positives = 32/70 (45%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G T L  AA  GQ   ++   + GA   +K     TPL+ +A  G    V+ LL+ GA P
Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP 525

Query: 179 RVYAEDGSTP 188
                 G TP
Sbjct: 526 NAATTSGYTP 535



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 28/92 (30%), Positives = 42/92 (45%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           A  L  R A  +       TPL  A+  G    ++L  + GA  ++K   G TPL+  A 
Sbjct: 251 ATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGAR 310

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            GH   VE+LL   A      ++G +P  +A+
Sbjct: 311 SGHEQVVEMLLDRAAPILSKTKNGLSPLHMAT 342



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 32/118 (27%), Positives = 47/118 (39%), Gaps = 16/118 (13%)

Query: 84  EVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGA 143
           EV  LL ++    D AG++                G TPL  AA         L  + GA
Sbjct: 579 EVANLLLQKSASPDAAGKS----------------GLTPLHVAAHYDNQKVALLLLDQGA 622

Query: 144 SPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 201
           SP++    G TPL+ AA    +     LL+ GAD       G     +A+ +  V ++
Sbjct: 623 SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMV 680



 Score = 36.6 bits (83), Expect = 0.052
 Identities = 29/96 (30%), Positives = 43/96 (44%)

Query: 98  EAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLY 157
           +A   ++L ++ A      + G TPL  +A  G         + GAS +     G TPL+
Sbjct: 511 KADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLH 570

Query: 158 RAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            AA  G L    +LL+  A P    + G TP  VA+
Sbjct: 571 VAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAA 606



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 23/75 (30%), Positives = 35/75 (46%)

Query: 99  AGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYR 158
           A   + L  R A  + +   G TPL   A  G    +++  +  A   SK   G +PL+ 
Sbjct: 281 ANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHM 340

Query: 159 AAFGGHLAAVEVLLK 173
           A  G HL  V++LL+
Sbjct: 341 ATQGDHLNCVQLLLQ 355



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 29/107 (27%), Positives = 45/107 (42%), Gaps = 7/107 (6%)

Query: 89  LTREGVG--HDEAGEAR-----RLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAEL 141
           +TR+G+   H  A E        L  R A     +  G TPL  AA   +    ++    
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQ 719

Query: 142 GASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTP 188
           GA  +++   G TPL+     G++  V  LL+  A      ++G TP
Sbjct: 720 GAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTP 766


>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
          Length = 2663

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 41/106 (38%), Positives = 59/106 (55%), Gaps = 5/106 (4%)

Query: 100 GEARRLQRRV---ALAECEDSYGNTPLSEAAAGGQ-PLAIQLRAELGASPNSKGAFGPTP 155
           G+ARR++  +   A    +D  G T L EA   G   +A QL A  GA  N+KG    TP
Sbjct: 179 GDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAA-GAEVNTKGLDDDTP 237

Query: 156 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 201
           L+ AA  GH   V++LL+ G +P+     G TP +VA+  T+V++L
Sbjct: 238 LHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLL 283



 Score = 29.3 bits (64), Expect = 8.4
 Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 7/114 (6%)

Query: 39  RRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQLLTREGVGHDE 98
           RRR +  R  R  +  F + + R  L +  E+R+E  E+     K V   L+ +     E
Sbjct: 888 RRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEK----HKSVPGYLSEKDKKRRE 943

Query: 99  AGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 152
           + EA R  R+ AL  C++        E A   +    +   E G    S G FG
Sbjct: 944 SAEAGR-DRKDALESCKERRDGRAKPEEAHREE--LKECGCESGFKDKSDGDFG 994


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 35/88 (39%), Positives = 45/88 (51%)

Query: 105 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 164
           L  +  + E     GNT L  AA  GQ   ++     GA+ N++   G TPLY AA   H
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 165 LAAVEVLLKLGADPRVYAEDGSTPERVA 192
           L  V+ LL+ GA+  V  EDG TP  VA
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVA 151



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 40/109 (36%), Positives = 51/109 (46%), Gaps = 2/109 (1%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GH E   A  L  + A   C    G TPL  AA  G+    +L  E  A PN+ G  G T
Sbjct: 514 GHVETVLA--LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRS 203
           PL+ A    +L  V++LL  G  P   A +G TP  +A+    V V RS
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 30/73 (41%), Positives = 38/73 (52%)

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 180
           TPL  AA  G     ++  + GA PNS+   G TPL+ A    H+  +E+LLK GA    
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 181 YAEDGSTPERVAS 193
             E G TP  VAS
Sbjct: 400 VTESGLTPLHVAS 412



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 30/82 (36%), Positives = 43/82 (52%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A+  G    ++   +  A  N+K   G +PL++AA  GH   V +LLK GA P
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
              + DG+TP  +A     +SV
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISV 782



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 34/99 (34%), Positives = 45/99 (45%), Gaps = 2/99 (2%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GH E   A+ L +  A    +     TPL  AA  G    ++L  E  A+PN     G T
Sbjct: 448 GHTEV--AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
           PL+ AA  GH+  V  LL+  A      + G TP  VA+
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 9/110 (8%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A        ++L  + GAS ++    G TPL+ A+F GHL  V+ LL+ GA P
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 179 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQ 228
            V      TP  +A+        R+    + + +LQN +A+   +A++ Q
Sbjct: 431 NVSNVKVETPLHMAA--------RAGHTEVAKYLLQN-KAKVNAKAKDDQ 471



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 35/125 (28%), Positives = 59/125 (47%), Gaps = 5/125 (4%)

Query: 96  HDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTP 155
           ++    A+ L  R A        G TPL  A+  G  + ++L  + GA   +K     TP
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275

Query: 156 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVLRSWDLSLTEA 211
           L+ AA  GH+   E+LL  GA  +   ++G +P  +A+    LD  V +L  +D  + + 
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD-CVRLLLQYDAEIDDI 334

Query: 212 MLQNM 216
            L ++
Sbjct: 335 TLDHL 339



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 32/92 (34%), Positives = 39/92 (42%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           AR L +    A  E   G TPL  AA  G    + L     A+ N     G TPL+  A 
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            GH+   +VL+K G         G TP  VAS
Sbjct: 678 EGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 4/103 (3%)

Query: 103 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 162
           + L +R A     +    TPL  AA  G     +   +  A  N+K     TPL+ AA  
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 163 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVL 201
           GH   V++LL+  A+P +    G TP  +A+    ++TV+++L
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 26/75 (34%), Positives = 35/75 (46%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A+  G    ++   + GASPN       TPL+ AA  GH    + LL+  A  
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 179 RVYAEDGSTPERVAS 193
              A+D  TP   A+
Sbjct: 464 NAKAKDDQTPLHCAA 478



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 27/82 (32%), Positives = 39/82 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA   Q    +   + G S N++   G TPL+ AA  GH   V +LL   A+ 
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
            +  + G TP  + + +  V V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPV 683



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 27/74 (36%), Positives = 35/74 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G+TPL  AA  G    +    E  AS       G TPL+ AA  G +   E+LL+  A P
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562

Query: 179 RVYAEDGSTPERVA 192
               ++G TP  VA
Sbjct: 563 NAAGKNGLTPLHVA 576



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 30/91 (32%), Positives = 42/91 (46%)

Query: 103 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 162
           R L  R A  E +     TPL  AA  G     ++  + GA   +K   G +P++ AA G
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315

Query: 163 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            HL  V +LL+  A+      D  TP  VA+
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 38/126 (30%), Positives = 53/126 (42%), Gaps = 3/126 (2%)

Query: 77  QMETPQK-EVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAI 135
           Q+ET  K E+  L      GH    E   L    A  + +   G +P+  AA G     +
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEI--LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321

Query: 136 QLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLD 195
           +L  +  A  +       TPL+ AA  GH    +VLL  GA P   A +G TP  +A   
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 381

Query: 196 TVVSVL 201
             V V+
Sbjct: 382 NHVRVM 387



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 20/53 (37%), Positives = 29/53 (54%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVL 171
           G +PL +AA  G    + L  + GASPN   + G TPL  A   G+++  +VL
Sbjct: 734 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 27/75 (36%), Positives = 34/75 (45%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA        QL    GAS N     G TPL+ A+  G++  V +LL  GA  
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265

Query: 179 RVYAEDGSTPERVAS 193
               +D  TP   A+
Sbjct: 266 ETKTKDELTPLHCAA 280



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 27/92 (29%), Positives = 36/92 (39%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           A  L  R A        G TPL  A        ++L    G SP+S    G TPL+ AA 
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
              +     LL+ G      +  G TP  +A+
Sbjct: 612 QNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643



 Score = 29.6 bits (65), Expect = 6.4
 Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 2/86 (2%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           G DE    R L    A    +   G TPL  AA       ++   E GA+ N     G T
Sbjct: 89  GQDEV--VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRV 180
           PL  A   GH   V  L+  G   +V
Sbjct: 147 PLAVALQQGHENVVAHLINYGTKGKV 172



 Score = 29.3 bits (64), Expect = 8.4
 Identities = 17/50 (34%), Positives = 26/50 (52%)

Query: 144 SPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
           +P+     G TPL+ AA   +L   ++LL  GA      ++G TP  +AS
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 35/88 (39%), Positives = 45/88 (51%)

Query: 105 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 164
           L  +  + E     GNT L  AA  GQ   ++     GA+ N++   G TPLY AA   H
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 165 LAAVEVLLKLGADPRVYAEDGSTPERVA 192
           L  V+ LL+ GA+  V  EDG TP  VA
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVA 151



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 40/109 (36%), Positives = 51/109 (46%), Gaps = 2/109 (1%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GH E   A  L  + A   C    G TPL  AA  G+    +L  E  A PN+ G  G T
Sbjct: 514 GHVETVLA--LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRS 203
           PL+ A    +L  V++LL  G  P   A +G TP  +A+    V V RS
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 30/73 (41%), Positives = 38/73 (52%)

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 180
           TPL  AA  G     ++  + GA PNS+   G TPL+ A    H+  +E+LLK GA    
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 181 YAEDGSTPERVAS 193
             E G TP  VAS
Sbjct: 400 VTESGLTPLHVAS 412



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 30/82 (36%), Positives = 43/82 (52%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A+  G    ++   +  A  N+K   G +PL++AA  GH   V +LLK GA P
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
              + DG+TP  +A     +SV
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISV 782



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 34/99 (34%), Positives = 45/99 (45%), Gaps = 2/99 (2%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GH E   A+ L +  A    +     TPL  AA  G    ++L  E  A+PN     G T
Sbjct: 448 GHTEV--AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
           PL+ AA  GH+  V  LL+  A      + G TP  VA+
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 9/110 (8%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A        ++L  + GAS ++    G TPL+ A+F GHL  V+ LL+ GA P
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 179 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQ 228
            V      TP  +A+        R+    + + +LQN +A+   +A++ Q
Sbjct: 431 NVSNVKVETPLHMAA--------RAGHTEVAKYLLQN-KAKVNAKAKDDQ 471



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 35/125 (28%), Positives = 59/125 (47%), Gaps = 5/125 (4%)

Query: 96  HDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTP 155
           ++    A+ L  R A        G TPL  A+  G  + ++L  + GA   +K     TP
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275

Query: 156 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVLRSWDLSLTEA 211
           L+ AA  GH+   E+LL  GA  +   ++G +P  +A+    LD  V +L  +D  + + 
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD-CVRLLLQYDAEIDDI 334

Query: 212 MLQNM 216
            L ++
Sbjct: 335 TLDHL 339



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 32/92 (34%), Positives = 39/92 (42%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           AR L +    A  E   G TPL  AA  G    + L     A+ N     G TPL+  A 
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            GH+   +VL+K G         G TP  VAS
Sbjct: 678 EGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 4/103 (3%)

Query: 103 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 162
           + L +R A     +    TPL  AA  G     +   +  A  N+K     TPL+ AA  
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 163 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVL 201
           GH   V++LL+  A+P +    G TP  +A+    ++TV+++L
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 26/75 (34%), Positives = 35/75 (46%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A+  G    ++   + GASPN       TPL+ AA  GH    + LL+  A  
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 179 RVYAEDGSTPERVAS 193
              A+D  TP   A+
Sbjct: 464 NAKAKDDQTPLHCAA 478



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 27/82 (32%), Positives = 39/82 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA   Q    +   + G S N++   G TPL+ AA  GH   V +LL   A+ 
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
            +  + G TP  + + +  V V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPV 683



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 27/74 (36%), Positives = 35/74 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G+TPL  AA  G    +    E  AS       G TPL+ AA  G +   E+LL+  A P
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562

Query: 179 RVYAEDGSTPERVA 192
               ++G TP  VA
Sbjct: 563 NAAGKNGLTPLHVA 576



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 30/91 (32%), Positives = 42/91 (46%)

Query: 103 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 162
           R L  R A  E +     TPL  AA  G     ++  + GA   +K   G +P++ AA G
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315

Query: 163 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            HL  V +LL+  A+      D  TP  VA+
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 38/126 (30%), Positives = 53/126 (42%), Gaps = 3/126 (2%)

Query: 77  QMETPQK-EVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAI 135
           Q+ET  K E+  L      GH    E   L    A  + +   G +P+  AA G     +
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEI--LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321

Query: 136 QLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLD 195
           +L  +  A  +       TPL+ AA  GH    +VLL  GA P   A +G TP  +A   
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 381

Query: 196 TVVSVL 201
             V V+
Sbjct: 382 NHVRVM 387



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 20/53 (37%), Positives = 29/53 (54%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVL 171
           G +PL +AA  G    + L  + GASPN   + G TPL  A   G+++  +VL
Sbjct: 734 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 27/75 (36%), Positives = 34/75 (45%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA        QL    GAS N     G TPL+ A+  G++  V +LL  GA  
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265

Query: 179 RVYAEDGSTPERVAS 193
               +D  TP   A+
Sbjct: 266 ETKTKDELTPLHCAA 280



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 27/92 (29%), Positives = 36/92 (39%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           A  L  R A        G TPL  A        ++L    G SP+S    G TPL+ AA 
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
              +     LL+ G      +  G TP  +A+
Sbjct: 612 QNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643



 Score = 29.6 bits (65), Expect = 6.4
 Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 2/86 (2%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           G DE    R L    A    +   G TPL  AA       ++   E GA+ N     G T
Sbjct: 89  GQDEV--VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRV 180
           PL  A   GH   V  L+  G   +V
Sbjct: 147 PLAVALQQGHENVVAHLINYGTKGKV 172



 Score = 29.3 bits (64), Expect = 8.4
 Identities = 17/50 (34%), Positives = 26/50 (52%)

Query: 144 SPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
           +P+     G TPL+ AA   +L   ++LL  GA      ++G TP  +AS
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 35/88 (39%), Positives = 45/88 (51%)

Query: 105 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 164
           L  +  + E     GNT L  AA  GQ   ++     GA+ N++   G TPLY AA   H
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 165 LAAVEVLLKLGADPRVYAEDGSTPERVA 192
           L  V+ LL+ GA+  V  EDG TP  VA
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVA 151



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 40/109 (36%), Positives = 51/109 (46%), Gaps = 2/109 (1%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GH E   A  L  + A   C    G TPL  AA  G+    +L  E  A PN+ G  G T
Sbjct: 514 GHVETVLA--LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRS 203
           PL+ A    +L  V++LL  G  P   A +G TP  +A+    V V RS
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 30/73 (41%), Positives = 38/73 (52%)

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 180
           TPL  AA  G     ++  + GA PNS+   G TPL+ A    H+  +E+LLK GA    
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 181 YAEDGSTPERVAS 193
             E G TP  VAS
Sbjct: 400 VTESGLTPLHVAS 412



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 30/82 (36%), Positives = 43/82 (52%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A+  G    ++   +  A  N+K   G +PL++AA  GH   V +LLK GA P
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
              + DG+TP  +A     +SV
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISV 782



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 34/99 (34%), Positives = 45/99 (45%), Gaps = 2/99 (2%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GH E   A+ L +  A    +     TPL  AA  G    ++L  E  A+PN     G T
Sbjct: 448 GHTEV--AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
           PL+ AA  GH+  V  LL+  A      + G TP  VA+
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 9/110 (8%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A        ++L  + GAS ++    G TPL+ A+F GHL  V+ LL+ GA P
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 179 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQ 228
            V      TP  +A+        R+    + + +LQN +A+   +A++ Q
Sbjct: 431 NVSNVKVETPLHMAA--------RAGHTEVAKYLLQN-KAKVNAKAKDDQ 471



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 35/125 (28%), Positives = 59/125 (47%), Gaps = 5/125 (4%)

Query: 96  HDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTP 155
           ++    A+ L  R A        G TPL  A+  G  + ++L  + GA   +K     TP
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275

Query: 156 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVLRSWDLSLTEA 211
           L+ AA  GH+   E+LL  GA  +   ++G +P  +A+    LD  V +L  +D  + + 
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD-CVRLLLQYDAEIDDI 334

Query: 212 MLQNM 216
            L ++
Sbjct: 335 TLDHL 339



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 32/92 (34%), Positives = 39/92 (42%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           AR L +    A  E   G TPL  AA  G    + L     A+ N     G TPL+  A 
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            GH+   +VL+K G         G TP  VAS
Sbjct: 678 EGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 4/103 (3%)

Query: 103 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 162
           + L +R A     +    TPL  AA  G     +   +  A  N+K     TPL+ AA  
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 163 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVL 201
           GH   V++LL+  A+P +    G TP  +A+    ++TV+++L
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 26/75 (34%), Positives = 35/75 (46%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A+  G    ++   + GASPN       TPL+ AA  GH    + LL+  A  
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 179 RVYAEDGSTPERVAS 193
              A+D  TP   A+
Sbjct: 464 NAKAKDDQTPLHCAA 478



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 27/82 (32%), Positives = 39/82 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA   Q    +   + G S N++   G TPL+ AA  GH   V +LL   A+ 
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
            +  + G TP  + + +  V V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPV 683



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 27/74 (36%), Positives = 35/74 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G+TPL  AA  G    +    E  AS       G TPL+ AA  G +   E+LL+  A P
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562

Query: 179 RVYAEDGSTPERVA 192
               ++G TP  VA
Sbjct: 563 NAAGKNGLTPLHVA 576



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 30/91 (32%), Positives = 42/91 (46%)

Query: 103 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 162
           R L  R A  E +     TPL  AA  G     ++  + GA   +K   G +P++ AA G
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315

Query: 163 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            HL  V +LL+  A+      D  TP  VA+
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 38/126 (30%), Positives = 53/126 (42%), Gaps = 3/126 (2%)

Query: 77  QMETPQK-EVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAI 135
           Q+ET  K E+  L      GH    E   L    A  + +   G +P+  AA G     +
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEI--LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321

Query: 136 QLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLD 195
           +L  +  A  +       TPL+ AA  GH    +VLL  GA P   A +G TP  +A   
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 381

Query: 196 TVVSVL 201
             V V+
Sbjct: 382 NHVRVM 387



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 20/53 (37%), Positives = 29/53 (54%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVL 171
           G +PL +AA  G    + L  + GASPN   + G TPL  A   G+++  +VL
Sbjct: 734 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 27/75 (36%), Positives = 34/75 (45%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA        QL    GAS N     G TPL+ A+  G++  V +LL  GA  
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265

Query: 179 RVYAEDGSTPERVAS 193
               +D  TP   A+
Sbjct: 266 ETKTKDELTPLHCAA 280



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 27/92 (29%), Positives = 36/92 (39%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           A  L  R A        G TPL  A        ++L    G SP+S    G TPL+ AA 
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
              +     LL+ G      +  G TP  +A+
Sbjct: 612 QNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643



 Score = 29.6 bits (65), Expect = 6.4
 Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 2/86 (2%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           G DE    R L    A    +   G TPL  AA       ++   E GA+ N     G T
Sbjct: 89  GQDEV--VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRV 180
           PL  A   GH   V  L+  G   +V
Sbjct: 147 PLAVALQQGHENVVAHLINYGTKGKV 172



 Score = 29.3 bits (64), Expect = 8.4
 Identities = 17/50 (34%), Positives = 26/50 (52%)

Query: 144 SPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
           +P+     G TPL+ AA   +L   ++LL  GA      ++G TP  +AS
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 35/88 (39%), Positives = 45/88 (51%)

Query: 105 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 164
           L  +  + E     GNT L  AA  GQ   ++     GA+ N++   G TPLY AA   H
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 165 LAAVEVLLKLGADPRVYAEDGSTPERVA 192
           L  V+ LL+ GA+  V  EDG TP  VA
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVA 151



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 40/109 (36%), Positives = 51/109 (46%), Gaps = 2/109 (1%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GH E   A  L  + A   C    G TPL  AA  G+    +L  E  A PN+ G  G T
Sbjct: 514 GHVETVLA--LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRS 203
           PL+ A    +L  V++LL  G  P   A +G TP  +A+    V V RS
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 30/73 (41%), Positives = 38/73 (52%)

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 180
           TPL  AA  G     ++  + GA PNS+   G TPL+ A    H+  +E+LLK GA    
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 181 YAEDGSTPERVAS 193
             E G TP  VAS
Sbjct: 400 VTESGLTPLHVAS 412



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 30/82 (36%), Positives = 43/82 (52%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A+  G    ++   +  A  N+K   G +PL++AA  GH   V +LLK GA P
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
              + DG+TP  +A     +SV
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISV 782



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 34/99 (34%), Positives = 45/99 (45%), Gaps = 2/99 (2%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GH E   A+ L +  A    +     TPL  AA  G    ++L  E  A+PN     G T
Sbjct: 448 GHTEV--AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
           PL+ AA  GH+  V  LL+  A      + G TP  VA+
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 9/110 (8%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A        ++L  + GAS ++    G TPL+ A+F GHL  V+ LL+ GA P
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 179 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQ 228
            V      TP  +A+        R+    + + +LQN +A+   +A++ Q
Sbjct: 431 NVSNVKVETPLHMAA--------RAGHTEVAKYLLQN-KAKVNAKAKDDQ 471



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 35/125 (28%), Positives = 59/125 (47%), Gaps = 5/125 (4%)

Query: 96  HDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTP 155
           ++    A+ L  R A        G TPL  A+  G  + ++L  + GA   +K     TP
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275

Query: 156 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVLRSWDLSLTEA 211
           L+ AA  GH+   E+LL  GA  +   ++G +P  +A+    LD  V +L  +D  + + 
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD-CVRLLLQYDAEIDDI 334

Query: 212 MLQNM 216
            L ++
Sbjct: 335 TLDHL 339



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 32/92 (34%), Positives = 39/92 (42%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           AR L +    A  E   G TPL  AA  G    + L     A+ N     G TPL+  A 
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            GH+   +VL+K G         G TP  VAS
Sbjct: 678 EGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 4/103 (3%)

Query: 103 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 162
           + L +R A     +    TPL  AA  G     +   +  A  N+K     TPL+ AA  
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 163 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVL 201
           GH   V++LL+  A+P +    G TP  +A+    ++TV+++L
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 26/75 (34%), Positives = 35/75 (46%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A+  G    ++   + GASPN       TPL+ AA  GH    + LL+  A  
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463

Query: 179 RVYAEDGSTPERVAS 193
              A+D  TP   A+
Sbjct: 464 NAKAKDDQTPLHCAA 478



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 27/82 (32%), Positives = 39/82 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA   Q    +   + G S N++   G TPL+ AA  GH   V +LL   A+ 
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
            +  + G TP  + + +  V V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPV 683



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 27/74 (36%), Positives = 35/74 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G+TPL  AA  G    +    E  AS       G TPL+ AA  G +   E+LL+  A P
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562

Query: 179 RVYAEDGSTPERVA 192
               ++G TP  VA
Sbjct: 563 NAAGKNGLTPLHVA 576



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 30/91 (32%), Positives = 42/91 (46%)

Query: 103 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 162
           R L  R A  E +     TPL  AA  G     ++  + GA   +K   G +P++ AA G
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315

Query: 163 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            HL  V +LL+  A+      D  TP  VA+
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 38/126 (30%), Positives = 53/126 (42%), Gaps = 3/126 (2%)

Query: 77  QMETPQK-EVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAI 135
           Q+ET  K E+  L      GH    E   L    A  + +   G +P+  AA G     +
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEI--LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321

Query: 136 QLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLD 195
           +L  +  A  +       TPL+ AA  GH    +VLL  GA P   A +G TP  +A   
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 381

Query: 196 TVVSVL 201
             V V+
Sbjct: 382 NHVRVM 387



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 20/53 (37%), Positives = 29/53 (54%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVL 171
           G +PL +AA  G    + L  + GASPN   + G TPL  A   G+++  +VL
Sbjct: 734 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 27/75 (36%), Positives = 34/75 (45%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA        QL    GAS N     G TPL+ A+  G++  V +LL  GA  
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265

Query: 179 RVYAEDGSTPERVAS 193
               +D  TP   A+
Sbjct: 266 ETKTKDELTPLHCAA 280



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 27/92 (29%), Positives = 36/92 (39%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           A  L  R A        G TPL  A        ++L    G SP+S    G TPL+ AA 
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
              +     LL+ G      +  G TP  +A+
Sbjct: 612 QNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643



 Score = 29.6 bits (65), Expect = 6.4
 Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 2/86 (2%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           G DE    R L    A    +   G TPL  AA       ++   E GA+ N     G T
Sbjct: 89  GQDEV--VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRV 180
           PL  A   GH   V  L+  G   +V
Sbjct: 147 PLAVALQQGHENVVAHLINYGTKGKV 172



 Score = 29.3 bits (64), Expect = 8.4
 Identities = 17/50 (34%), Positives = 26/50 (52%)

Query: 144 SPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
           +P+     G TPL+ AA   +L   ++LL  GA      ++G TP  +AS
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 68/285 (23%), Positives = 116/285 (40%), Gaps = 19/285 (6%)

Query: 57   QLRARRELARRREERREYLEQMETPQKEVEQLL------TREGVGHDEAGEARRLQRRVA 110
            Q R + E+ RR E   +  +Q  + Q+E++QL        +      EA E  RL+    
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453

Query: 111  LAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEV 170
            +         T      A G+  A++ RAE   +   +       L R          + 
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513

Query: 171  LLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQ----E 226
             ++L +  RV AE  +  E+  +L  +  +         E  L+  E E+ R+ Q     
Sbjct: 1514 EVELAS--RVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALET 1569

Query: 227  AQRHKEAEAE----RMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK 282
            AQR  EAE +        K  QL R  Q+ H  + Q   E  RR  +  + E R  ++ +
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAE 1628

Query: 283  LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 327
              L+  +    +  RLR +A++  +  ++A+ E  +Q +E E EA
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 68/312 (21%), Positives = 134/312 (42%), Gaps = 34/312 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            L+ +    +  RR AED A       F++ R   + A+ + +  E L Q+        +L
Sbjct: 1856 LKEKEAENERLRRLAEDEA-------FQRRRLEEQAAQHKADIEERLAQLRKASDS--EL 1906

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
              ++G+  D   + R+++  +   +           +AAAG   L ++L      + ++ 
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELGRIRSNAEDTL 1959

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASLDTVVSV---- 200
             +     L  AA    LAA E   +  A+ RV     AE+ +  +R A+L+ V  +    
Sbjct: 1960 RSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018

Query: 201  -----LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKE 255
                 LR      +   LQ  +   Q+R Q  ++      ++   ++QQ  +++Q    +
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078

Query: 256  LQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLE 315
            L +   E +RR +E  + E   +   +   Q+ +  E + +RL+Q A++  +A A A+  
Sbjct: 2079 L-RGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAA 2134

Query: 316  LREQTQEGEEEA 327
              +  +E E+EA
Sbjct: 2135 AEKLRKEAEQEA 2146



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 69/304 (22%), Positives = 124/304 (40%), Gaps = 36/304 (11%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQG----AFRQLRARRELARRREERREYLEQMETPQKE 84
            LRAR    + ++R A++ A R  +     + R+ +A  ELA R +   E   + +   + 
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537

Query: 85   VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS 144
            +E+L            +A   +RR+  AE E +       E A       +Q +    A 
Sbjct: 1538 LEELRL----------QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587

Query: 145  PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW 204
              ++       L R+    H+A  +  L+  A+ R  A+  +  ER    +     L  W
Sbjct: 1588 KTAQ-------LERSLQEEHVAVAQ--LREEAERR--AQQQAEAERAR--EEAERELERW 1634

Query: 205  DLSLTEAM---LQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYC 261
             L   EA+   LQ  E  QQ+   +A+  K+ E      + +    EQ    +EL +   
Sbjct: 1635 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1694

Query: 262  ELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQ 321
            E  R+++E    +    ++  + L+      A+ ++  Q+ Q  EE LA  + E    TQ
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEELARLQREAAAATQ 1748

Query: 322  EGEE 325
            + +E
Sbjct: 1749 KRQE 1752



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 70/306 (22%), Positives = 126/306 (41%), Gaps = 32/306 (10%)

Query: 39   RRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQ------METPQKEVEQLLTRE 92
            RR  AE++A R  + A ++L  +R+LA    ++R   EQ       ET Q E ++ L  E
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1734

Query: 93   GVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 152
                    E  RLQR  A A  +       L++  A    + + L ++  A   S+    
Sbjct: 1735 --------ELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1783

Query: 153  PTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAM 212
             +     A  G       L +  A  R  AE+     ++A  D       + +  L E +
Sbjct: 1784 KSKQRLEAEAGRFRE---LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKL 1839

Query: 213  LQNMEAEQQR-RAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHD 271
                EA + +  A+ A + KEAE ER+    +    ++++  ++  Q   ++  R+++  
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899

Query: 272  QCEWRCMDKTK----LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLEL------REQTQ 321
            +     +++ K     TL+  +  E ++  L+   +KA    A   LEL       E T 
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959

Query: 322  EGEEEA 327
              +E+A
Sbjct: 1960 RSKEQA 1965



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 91/416 (21%), Positives = 166/416 (39%), Gaps = 74/416 (17%)

Query: 24   LGAPELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQK 83
            L A   R     ++ RRR AE+R  ++       L A  E AR+R+   E +E+++   +
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVE 2019

Query: 84   EVEQLLTREGVGHDEAGEARRL-------QRRVALAECEDSYG----NTPLSEAAAGGQP 132
            E  +L  R      E   AR+L       Q+R+   E   ++        L +     Q 
Sbjct: 2020 EARRLRERA-----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074

Query: 133  LAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA 192
            +  QLR E  A+             RAA            +   + RV AE  +   R  
Sbjct: 2075 VLDQLRGEAEAA------------RRAA------------EEAEEARVQAEREAAQSR-R 2109

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 252
             ++    + +S +            AE+ R+  E +  + A+AE+  L+ +Q    + + 
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2169

Query: 253  HKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMA 312
            HK+  +       ++ +         + T L LQ +++T+ Q + L +E Q+    L   
Sbjct: 2170 HKKFAEQTLRQKAQVEQ---------ELTTLRLQ-LEETDHQKNLLDEELQR----LKAE 2215

Query: 313  RLELREQTQEGEEEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQ 372
              E   Q  + EEE   ++ Q+ EL       +  RI A+ R  L++        FL+ +
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEEL-----SKLKARIEAENR-ALILRDKDNTQRFLQ-E 2268

Query: 373  DTNYVDTVNPEPLRPERMWLALLGALRYGKPLVFDLREEDLF--PVVQRQLEAVQE 426
            +   +  V  E     R+ +A   A R  +    DL ++      +++ +++AVQE
Sbjct: 2269 EAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2321



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 72/329 (21%), Positives = 128/329 (38%), Gaps = 43/329 (13%)

Query: 40   RRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQLLTREGVGHDEA 99
            R+ AE  AAR  Q     LR ++      E+ +++ EQ    + +VEQ LT   +  +E 
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198

Query: 100  G--------EARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS------- 144
                     E +RL+     A  + S     L       + L+ +L+A + A        
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIEAENRALILR 2257

Query: 145  --PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR 202
               N++                 A + V  +  A  R  AE+    +R  +      +L+
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA----EKMLK 2313

Query: 203  SWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQ 258
                ++ EA     EAE    Q+  AQE  R  + + E+M    QQL  E Q   + L+ 
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM---AQQLAEETQGFQRTLEA 2370

Query: 259  AYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELRE 318
                     +E ++ + R  + ++   +A +D +    R R++A++  E L    L  +E
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIGEKLHRTELATQE 2426

Query: 319  ----------QTQEGEEEAPGLKCQVTEL 337
                      Q Q+ + +A  L+  + EL
Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAEL 2455



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 67/302 (22%), Positives = 130/302 (43%), Gaps = 38/302 (12%)

Query: 49   RAIQGAFRQLRARRELARRREE-RREYLEQMETPQKEVEQLLTREGVGHDEAGEARRLQR 107
            +A+Q A R L+A  EL ++++E  +E   +++  ++++ Q L  E  G     EA R ++
Sbjct: 2317 QAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375

Query: 108  RVALAECED-SYGNTPLSEAAAGGQPLAIQLRA---ELGA-------SPNSKGAFGPTPL 156
                AE E        +S A A  +  A + R    E+G        +   K     T  
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435

Query: 157  YRAAFGGHLAAV--EVLLKLGADP----------RVYAEDGSTPERVASLDTVVSVLRSW 204
             +     H A    E + +L  +           ++ +E+  T ++   L    ++ +S+
Sbjct: 2436 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2495

Query: 205  DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS 264
             LS  +++LQ     +Q +A+  Q  ++  A+   L+ +Q  R+QQQ  +E Q+    + 
Sbjct: 2496 -LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASME 2553

Query: 265  RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 324
                   + E           + ++  + ++ +L Q+ ++ EE LA     LREQ Q  E
Sbjct: 2554 EARRRQHEAE-----------EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602

Query: 325  EE 326
            E+
Sbjct: 2603 EQ 2604



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/132 (25%), Positives = 65/132 (49%), Gaps = 13/132 (9%)

Query: 209  TEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRIS 268
            T+   + +EAE+QR     Q    AEAER+ L+V +++R Q +  ++ Q+ + + +  I 
Sbjct: 2361 TQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAEEDAQR-FRKQAEEIG 2414

Query: 269  EHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAP 328
            E        + +T+L  Q        ++  RQ++    E L  A  EL  + ++ ++EA 
Sbjct: 2415 EK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467

Query: 329  GLKCQVTELHDV 340
             L+ +  E+  V
Sbjct: 2468 LLQLKSEEMQTV 2479



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 77/339 (22%), Positives = 127/339 (37%), Gaps = 58/339 (17%)

Query: 28   ELRARRGSQDPRRRPAED--RAARAIQGAFRQLRARR--ELARRREERREYLE------- 76
            +LRA+  +Q P      D  R A+ +    +Q    R  E+ R RE   + LE       
Sbjct: 1134 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1193

Query: 77   QMETPQKEVEQLLTREGVGHDEAG-------EARRLQRRVALAECEDSYGNTPLSEAAAG 129
            Q +  Q+E+EQL  +     + A        +ARR Q ++      DS     + E    
Sbjct: 1194 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQ 1250

Query: 130  GQPLAIQLRAELGASPNSKGAFGPTPL-----YRAAFGGHLAAVEVLLKLGADPRVYAED 184
             Q L  ++    G        F    +     Y      + A +E +      P+V +  
Sbjct: 1251 EQALLEEIERH-GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309

Query: 185  GSTPERVASLDT---VVSVLRSWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAER 237
             S  +    L T    ++ L S  +      L+ ME E    +Q+RA+E  R + AE E 
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEA 1367

Query: 238  MTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDR 297
               K +QL     Q   + ++   EL +R+ E                + ++  EA VD 
Sbjct: 1368 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE----------------EVVRREEAAVDA 1411

Query: 298  LRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTE 336
             +Q+    EE      L+   Q+ E E +A   + +  E
Sbjct: 1412 QQQKRSIQEE------LQQLRQSSEAEIQAKARQAEAAE 1444



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 68/322 (21%), Positives = 129/322 (40%), Gaps = 33/322 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            LRA     + +R+  E+  A          R +RE A   ++R+E   ++   + E+E L
Sbjct: 1718 LRAETEQGEQQRQLLEEELA----------RLQREAAAATQKRQELEAELAKVRAEMEVL 1767

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
            L  +    +E+       ++   AE         L+E AA  + LA + + +   +   +
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRF---RELAEEAARLRALAEEAKRQRQLA--EE 1822

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV-YAEDGSTPERVASLDTVVSVLRSWDLS 207
             A              LAA+    +L  +  +   E  +  ER+  L    +  R     
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR---R 1879

Query: 208  LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKEL----------- 256
            L E   Q+ +A+ + R  + ++  ++E ER    V+   R+++Q  +E+           
Sbjct: 1880 LEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938

Query: 257  -QQAYCELS-RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARL 314
              +A  EL   RI  + +   R  ++ +L     +   A+ +R R+EA++  +    A  
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998

Query: 315  ELREQTQEGEEEAPGLKCQVTE 336
            E   Q +   EE   LK +V E
Sbjct: 1999 EAARQRKAALEEVERLKAKVEE 2020



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 3/91 (3%)

Query: 26   APELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEV 85
            A +LR  +  Q  +      R   +++ A R+     E  RR++E    L+Q+E  +++ 
Sbjct: 2527 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQ 2583

Query: 86   EQLLTREGVGHDEAGEARRLQRRVALAECED 116
            E+LL  E     E  +    Q R ALA  E+
Sbjct: 2584 EELLAEENQRLREQLQLLEEQHRAALAHSEE 2614



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 239
            SL   V ++RSW L    A  + ++ E+QR+A  + + H +A              +R+ 
Sbjct: 898  SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 953

Query: 240  LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 298
             +     RE   C    QQ    L +   E  +C+ RC+ + K + LQ        V RL
Sbjct: 954  AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 1007

Query: 299  RQEAQKAEEALAMARLELREQTQEGEEEAPG 329
            R    K E A   A+    +Q  + E E  G
Sbjct: 1008 RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1037


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 68/285 (23%), Positives = 116/285 (40%), Gaps = 19/285 (6%)

Query: 57   QLRARRELARRREERREYLEQMETPQKEVEQLL------TREGVGHDEAGEARRLQRRVA 110
            Q R + E+ RR E   +  +Q  + Q+E++QL        +      EA E  RL+    
Sbjct: 1398 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1457

Query: 111  LAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEV 170
            +         T      A G+  A++ RAE   +   +       L R          + 
Sbjct: 1458 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1517

Query: 171  LLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQ----E 226
             ++L +  RV AE  +  E+  +L  +  +         E  L+  E E+ R+ Q     
Sbjct: 1518 EVELAS--RVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALET 1573

Query: 227  AQRHKEAEAE----RMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK 282
            AQR  EAE +        K  QL R  Q+ H  + Q   E  RR  +  + E R  ++ +
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAE 1632

Query: 283  LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 327
              L+  +    +  RLR +A++  +  ++A+ E  +Q +E E EA
Sbjct: 1633 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1677



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 68/312 (21%), Positives = 134/312 (42%), Gaps = 34/312 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            L+ +    +  RR AED A       F++ R   + A+ + +  E L Q+        +L
Sbjct: 1860 LKEKEAENERLRRLAEDEA-------FQRRRLEEQAAQHKADIEERLAQLRKASDS--EL 1910

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
              ++G+  D   + R+++  +   +           +AAAG   L ++L      + ++ 
Sbjct: 1911 ERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELGRIRSNAEDTL 1963

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASLDTVVSV---- 200
             +     L  AA    LAA E   +  A+ RV     AE+ +  +R A+L+ V  +    
Sbjct: 1964 RSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2022

Query: 201  -----LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKE 255
                 LR      +   LQ  +   Q+R Q  ++      ++   ++QQ  +++Q    +
Sbjct: 2023 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2082

Query: 256  LQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLE 315
            L +   E +RR +E  + E   +   +   Q+ +  E + +RL+Q A++  +A A A+  
Sbjct: 2083 L-RGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAA 2138

Query: 316  LREQTQEGEEEA 327
              +  +E E+EA
Sbjct: 2139 AEKLRKEAEQEA 2150



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 69/304 (22%), Positives = 124/304 (40%), Gaps = 36/304 (11%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQG----AFRQLRARRELARRREERREYLEQMETPQKE 84
            LRAR    + ++R A++ A R  +     + R+ +A  ELA R +   E   + +   + 
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1541

Query: 85   VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS 144
            +E+L            +A   +RR+  AE E +       E A       +Q +    A 
Sbjct: 1542 LEELRL----------QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1591

Query: 145  PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW 204
              ++       L R+    H+A  +  L+  A+ R  A+  +  ER    +     L  W
Sbjct: 1592 KTAQ-------LERSLQEEHVAVAQ--LREEAERR--AQQQAEAERAR--EEAERELERW 1638

Query: 205  DLSLTEAM---LQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYC 261
             L   EA+   LQ  E  QQ+   +A+  K+ E      + +    EQ    +EL +   
Sbjct: 1639 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1698

Query: 262  ELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQ 321
            E  R+++E    +    ++  + L+      A+ ++  Q+ Q  EE LA  + E    TQ
Sbjct: 1699 EKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEELARLQREAAAATQ 1752

Query: 322  EGEE 325
            + +E
Sbjct: 1753 KRQE 1756



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 70/306 (22%), Positives = 126/306 (41%), Gaps = 32/306 (10%)

Query: 39   RRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQ------METPQKEVEQLLTRE 92
            RR  AE++A R  + A ++L  +R+LA    ++R   EQ       ET Q E ++ L  E
Sbjct: 1679 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1738

Query: 93   GVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 152
                    E  RLQR  A A  +       L++  A    + + L ++  A   S+    
Sbjct: 1739 --------ELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1787

Query: 153  PTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAM 212
             +     A  G       L +  A  R  AE+     ++A  D       + +  L E +
Sbjct: 1788 KSKQRLEAEAGRFRE---LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKL 1843

Query: 213  LQNMEAEQQR-RAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHD 271
                EA + +  A+ A + KEAE ER+    +    ++++  ++  Q   ++  R+++  
Sbjct: 1844 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903

Query: 272  QCEWRCMDKTK----LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLEL------REQTQ 321
            +     +++ K     TL+  +  E ++  L+   +KA    A   LEL       E T 
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1963

Query: 322  EGEEEA 327
              +E+A
Sbjct: 1964 RSKEQA 1969



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 91/416 (21%), Positives = 166/416 (39%), Gaps = 74/416 (17%)

Query: 24   LGAPELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQK 83
            L A   R     ++ RRR AE+R  ++       L A  E AR+R+   E +E+++   +
Sbjct: 1971 LEAARQRQLAAEEERRRREAEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVE 2023

Query: 84   EVEQLLTREGVGHDEAGEARRL-------QRRVALAECEDSYG----NTPLSEAAAGGQP 132
            E  +L  R      E   AR+L       Q+R+   E   ++        L +     Q 
Sbjct: 2024 EARRLRERA-----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078

Query: 133  LAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA 192
            +  QLR E  A+             RAA            +   + RV AE  +   R  
Sbjct: 2079 VLDQLRGEAEAA------------RRAA------------EEAEEARVQAEREAAQSR-R 2113

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 252
             ++    + +S +            AE+ R+  E +  + A+AE+  L+ +Q    + + 
Sbjct: 2114 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2173

Query: 253  HKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMA 312
            HK+  +       ++ +         + T L LQ +++T+ Q + L +E Q+    L   
Sbjct: 2174 HKKFAEQTLRQKAQVEQ---------ELTTLRLQ-LEETDHQKNLLDEELQR----LKAE 2219

Query: 313  RLELREQTQEGEEEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQ 372
              E   Q  + EEE   ++ Q+ EL       +  RI A+ R  L++        FL+ +
Sbjct: 2220 ATEAARQRSQVEEELFSVRVQMEEL-----SKLKARIEAENR-ALILRDKDNTQRFLQ-E 2272

Query: 373  DTNYVDTVNPEPLRPERMWLALLGALRYGKPLVFDLREEDLF--PVVQRQLEAVQE 426
            +   +  V  E     R+ +A   A R  +    DL ++      +++ +++AVQE
Sbjct: 2273 EAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2325



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 72/329 (21%), Positives = 128/329 (38%), Gaps = 43/329 (13%)

Query: 40   RRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQLLTREGVGHDEA 99
            R+ AE  AAR  Q     LR ++      E+ +++ EQ    + +VEQ LT   +  +E 
Sbjct: 2143 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2202

Query: 100  G--------EARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS------- 144
                     E +RL+     A  + S     L       + L+ +L+A + A        
Sbjct: 2203 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIEAENRALILR 2261

Query: 145  --PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR 202
               N++                 A + V  +  A  R  AE+    +R  +      +L+
Sbjct: 2262 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA----EKMLK 2317

Query: 203  SWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQ 258
                ++ EA     EAE    Q+  AQE  R  + + E+M    QQL  E Q   + L+ 
Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM---AQQLAEETQGFQRTLEA 2374

Query: 259  AYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELRE 318
                     +E ++ + R  + ++   +A +D +    R R++A++  E L    L  +E
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIGEKLHRTELATQE 2430

Query: 319  ----------QTQEGEEEAPGLKCQVTEL 337
                      Q Q+ + +A  L+  + EL
Sbjct: 2431 KVTLVQTLEIQRQQSDHDAERLREAIAEL 2459



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 67/302 (22%), Positives = 130/302 (43%), Gaps = 38/302 (12%)

Query: 49   RAIQGAFRQLRARRELARRREE-RREYLEQMETPQKEVEQLLTREGVGHDEAGEARRLQR 107
            +A+Q A R L+A  EL ++++E  +E   +++  ++++ Q L  E  G     EA R ++
Sbjct: 2321 QAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2379

Query: 108  RVALAECED-SYGNTPLSEAAAGGQPLAIQLRA---ELGA-------SPNSKGAFGPTPL 156
                AE E        +S A A  +  A + R    E+G        +   K     T  
Sbjct: 2380 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2439

Query: 157  YRAAFGGHLAAV--EVLLKLGADP----------RVYAEDGSTPERVASLDTVVSVLRSW 204
             +     H A    E + +L  +           ++ +E+  T ++   L    ++ +S+
Sbjct: 2440 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2499

Query: 205  DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS 264
             LS  +++LQ     +Q +A+  Q  ++  A+   L+ +Q  R+QQQ  +E Q+    + 
Sbjct: 2500 -LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASME 2557

Query: 265  RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 324
                   + E           + ++  + ++ +L Q+ ++ EE LA     LREQ Q  E
Sbjct: 2558 EARRRQHEAE-----------EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2606

Query: 325  EE 326
            E+
Sbjct: 2607 EQ 2608



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/132 (25%), Positives = 65/132 (49%), Gaps = 13/132 (9%)

Query: 209  TEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRIS 268
            T+   + +EAE+QR     Q    AEAER+ L+V +++R Q +  ++ Q+ + + +  I 
Sbjct: 2365 TQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAEEDAQR-FRKQAEEIG 2418

Query: 269  EHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAP 328
            E        + +T+L  Q        ++  RQ++    E L  A  EL  + ++ ++EA 
Sbjct: 2419 EK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2471

Query: 329  GLKCQVTELHDV 340
             L+ +  E+  V
Sbjct: 2472 LLQLKSEEMQTV 2483



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 77/339 (22%), Positives = 127/339 (37%), Gaps = 58/339 (17%)

Query: 28   ELRARRGSQDPRRRPAED--RAARAIQGAFRQLRARR--ELARRREERREYLE------- 76
            +LRA+  +Q P      D  R A+ +    +Q    R  E+ R RE   + LE       
Sbjct: 1138 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1197

Query: 77   QMETPQKEVEQLLTREGVGHDEAG-------EARRLQRRVALAECEDSYGNTPLSEAAAG 129
            Q +  Q+E+EQL  +     + A        +ARR Q ++      DS     + E    
Sbjct: 1198 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQ 1254

Query: 130  GQPLAIQLRAELGASPNSKGAFGPTPL-----YRAAFGGHLAAVEVLLKLGADPRVYAED 184
             Q L  ++    G        F    +     Y      + A +E +      P+V +  
Sbjct: 1255 EQALLEEIERH-GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1313

Query: 185  GSTPERVASLDT---VVSVLRSWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAER 237
             S  +    L T    ++ L S  +      L+ ME E    +Q+RA+E  R + AE E 
Sbjct: 1314 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEA 1371

Query: 238  MTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDR 297
               K +QL     Q   + ++   EL +R+ E                + ++  EA VD 
Sbjct: 1372 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE----------------EVVRREEAAVDA 1415

Query: 298  LRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTE 336
             +Q+    EE      L+   Q+ E E +A   + +  E
Sbjct: 1416 QQQKRSIQEE------LQQLRQSSEAEIQAKARQAEAAE 1448



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 68/322 (21%), Positives = 129/322 (40%), Gaps = 33/322 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            LRA     + +R+  E+  A          R +RE A   ++R+E   ++   + E+E L
Sbjct: 1722 LRAETEQGEQQRQLLEEELA----------RLQREAAAATQKRQELEAELAKVRAEMEVL 1771

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
            L  +    +E+       ++   AE         L+E AA  + LA + + +   +   +
Sbjct: 1772 LASKARAEEESRSTSEKSKQRLEAEAGRF---RELAEEAARLRALAEEAKRQRQLA--EE 1826

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV-YAEDGSTPERVASLDTVVSVLRSWDLS 207
             A              LAA+    +L  +  +   E  +  ER+  L    +  R     
Sbjct: 1827 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR---R 1883

Query: 208  LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKEL----------- 256
            L E   Q+ +A+ + R  + ++  ++E ER    V+   R+++Q  +E+           
Sbjct: 1884 LEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1942

Query: 257  -QQAYCELS-RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARL 314
              +A  EL   RI  + +   R  ++ +L     +   A+ +R R+EA++  +    A  
Sbjct: 1943 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2002

Query: 315  ELREQTQEGEEEAPGLKCQVTE 336
            E   Q +   EE   LK +V E
Sbjct: 2003 EAARQRKAALEEVERLKAKVEE 2024



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 3/91 (3%)

Query: 26   APELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEV 85
            A +LR  +  Q  +      R   +++ A R+     E  RR++E    L+Q+E  +++ 
Sbjct: 2531 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQ 2587

Query: 86   EQLLTREGVGHDEAGEARRLQRRVALAECED 116
            E+LL  E     E  +    Q R ALA  E+
Sbjct: 2588 EELLAEENQRLREQLQLLEEQHRAALAHSEE 2618



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 239
            SL   V ++RSW L    A  + ++ E+QR+A  + + H +A              +R+ 
Sbjct: 902  SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 957

Query: 240  LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 298
             +     RE   C    QQ    L +   E  +C+ RC+ + K + LQ        V RL
Sbjct: 958  AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 1011

Query: 299  RQEAQKAEEALAMARLELREQTQEGEEEAPG 329
            R    K E A   A+    +Q  + E E  G
Sbjct: 1012 RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1041


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 68/285 (23%), Positives = 116/285 (40%), Gaps = 19/285 (6%)

Query: 57   QLRARRELARRREERREYLEQMETPQKEVEQLL------TREGVGHDEAGEARRLQRRVA 110
            Q R + E+ RR E   +  +Q  + Q+E++QL        +      EA E  RL+    
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453

Query: 111  LAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEV 170
            +         T      A G+  A++ RAE   +   +       L R          + 
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513

Query: 171  LLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQ----E 226
             ++L +  RV AE  +  E+  +L  +  +         E  L+  E E+ R+ Q     
Sbjct: 1514 EVELAS--RVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALET 1569

Query: 227  AQRHKEAEAE----RMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK 282
            AQR  EAE +        K  QL R  Q+ H  + Q   E  RR  +  + E R  ++ +
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAE 1628

Query: 283  LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 327
              L+  +    +  RLR +A++  +  ++A+ E  +Q +E E EA
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 68/312 (21%), Positives = 134/312 (42%), Gaps = 34/312 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            L+ +    +  RR AED A       F++ R   + A+ + +  E L Q+        +L
Sbjct: 1856 LKEKEAENERLRRLAEDEA-------FQRRRLEEQAAQHKADIEERLAQLRKASDS--EL 1906

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
              ++G+  D   + R+++  +   +           +AAAG   L ++L      + ++ 
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELGRIRSNAEDTL 1959

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASLDTVVSV---- 200
             +     L  AA    LAA E   +  A+ RV     AE+ +  +R A+L+ V  +    
Sbjct: 1960 RSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018

Query: 201  -----LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKE 255
                 LR      +   LQ  +   Q+R Q  ++      ++   ++QQ  +++Q    +
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078

Query: 256  LQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLE 315
            L +   E +RR +E  + E   +   +   Q+ +  E + +RL+Q A++  +A A A+  
Sbjct: 2079 L-RGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAA 2134

Query: 316  LREQTQEGEEEA 327
              +  +E E+EA
Sbjct: 2135 AEKLRKEAEQEA 2146



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 69/304 (22%), Positives = 124/304 (40%), Gaps = 36/304 (11%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQG----AFRQLRARRELARRREERREYLEQMETPQKE 84
            LRAR    + ++R A++ A R  +     + R+ +A  ELA R +   E   + +   + 
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537

Query: 85   VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS 144
            +E+L            +A   +RR+  AE E +       E A       +Q +    A 
Sbjct: 1538 LEELRL----------QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587

Query: 145  PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW 204
              ++       L R+    H+A  +  L+  A+ R  A+  +  ER    +     L  W
Sbjct: 1588 KTAQ-------LERSLQEEHVAVAQ--LREEAERR--AQQQAEAERAR--EEAERELERW 1634

Query: 205  DLSLTEAM---LQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYC 261
             L   EA+   LQ  E  QQ+   +A+  K+ E      + +    EQ    +EL +   
Sbjct: 1635 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1694

Query: 262  ELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQ 321
            E  R+++E    +    ++  + L+      A+ ++  Q+ Q  EE LA  + E    TQ
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEELARLQREAAAATQ 1748

Query: 322  EGEE 325
            + +E
Sbjct: 1749 KRQE 1752



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 70/306 (22%), Positives = 126/306 (41%), Gaps = 32/306 (10%)

Query: 39   RRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQ------METPQKEVEQLLTRE 92
            RR  AE++A R  + A ++L  +R+LA    ++R   EQ       ET Q E ++ L  E
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1734

Query: 93   GVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 152
                    E  RLQR  A A  +       L++  A    + + L ++  A   S+    
Sbjct: 1735 --------ELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1783

Query: 153  PTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAM 212
             +     A  G       L +  A  R  AE+     ++A  D       + +  L E +
Sbjct: 1784 KSKQRLEAEAGRFRE---LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKL 1839

Query: 213  LQNMEAEQQR-RAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHD 271
                EA + +  A+ A + KEAE ER+    +    ++++  ++  Q   ++  R+++  
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899

Query: 272  QCEWRCMDKTK----LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLEL------REQTQ 321
            +     +++ K     TL+  +  E ++  L+   +KA    A   LEL       E T 
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959

Query: 322  EGEEEA 327
              +E+A
Sbjct: 1960 RSKEQA 1965



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 91/416 (21%), Positives = 166/416 (39%), Gaps = 74/416 (17%)

Query: 24   LGAPELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQK 83
            L A   R     ++ RRR AE+R  ++       L A  E AR+R+   E +E+++   +
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVE 2019

Query: 84   EVEQLLTREGVGHDEAGEARRL-------QRRVALAECEDSYG----NTPLSEAAAGGQP 132
            E  +L  R      E   AR+L       Q+R+   E   ++        L +     Q 
Sbjct: 2020 EARRLRERA-----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074

Query: 133  LAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA 192
            +  QLR E  A+             RAA            +   + RV AE  +   R  
Sbjct: 2075 VLDQLRGEAEAA------------RRAA------------EEAEEARVQAEREAAQSR-R 2109

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 252
             ++    + +S +            AE+ R+  E +  + A+AE+  L+ +Q    + + 
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2169

Query: 253  HKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMA 312
            HK+  +       ++ +         + T L LQ +++T+ Q + L +E Q+    L   
Sbjct: 2170 HKKFAEQTLRQKAQVEQ---------ELTTLRLQ-LEETDHQKNLLDEELQR----LKAE 2215

Query: 313  RLELREQTQEGEEEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQ 372
              E   Q  + EEE   ++ Q+ EL       +  RI A+ R  L++        FL+ +
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEEL-----SKLKARIEAENR-ALILRDKDNTQRFLQ-E 2268

Query: 373  DTNYVDTVNPEPLRPERMWLALLGALRYGKPLVFDLREEDLF--PVVQRQLEAVQE 426
            +   +  V  E     R+ +A   A R  +    DL ++      +++ +++AVQE
Sbjct: 2269 EAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2321



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 72/329 (21%), Positives = 128/329 (38%), Gaps = 43/329 (13%)

Query: 40   RRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQLLTREGVGHDEA 99
            R+ AE  AAR  Q     LR ++      E+ +++ EQ    + +VEQ LT   +  +E 
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198

Query: 100  G--------EARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS------- 144
                     E +RL+     A  + S     L       + L+ +L+A + A        
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIEAENRALILR 2257

Query: 145  --PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR 202
               N++                 A + V  +  A  R  AE+    +R  +      +L+
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA----EKMLK 2313

Query: 203  SWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQ 258
                ++ EA     EAE    Q+  AQE  R  + + E+M    QQL  E Q   + L+ 
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM---AQQLAEETQGFQRTLEA 2370

Query: 259  AYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELRE 318
                     +E ++ + R  + ++   +A +D +    R R++A++  E L    L  +E
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIGEKLHRTELATQE 2426

Query: 319  ----------QTQEGEEEAPGLKCQVTEL 337
                      Q Q+ + +A  L+  + EL
Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAEL 2455



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 67/302 (22%), Positives = 130/302 (43%), Gaps = 38/302 (12%)

Query: 49   RAIQGAFRQLRARRELARRREE-RREYLEQMETPQKEVEQLLTREGVGHDEAGEARRLQR 107
            +A+Q A R L+A  EL ++++E  +E   +++  ++++ Q L  E  G     EA R ++
Sbjct: 2317 QAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375

Query: 108  RVALAECED-SYGNTPLSEAAAGGQPLAIQLRA---ELGA-------SPNSKGAFGPTPL 156
                AE E        +S A A  +  A + R    E+G        +   K     T  
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435

Query: 157  YRAAFGGHLAAV--EVLLKLGADP----------RVYAEDGSTPERVASLDTVVSVLRSW 204
             +     H A    E + +L  +           ++ +E+  T ++   L    ++ +S+
Sbjct: 2436 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2495

Query: 205  DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS 264
             LS  +++LQ     +Q +A+  Q  ++  A+   L+ +Q  R+QQQ  +E Q+    + 
Sbjct: 2496 -LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASME 2553

Query: 265  RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 324
                   + E           + ++  + ++ +L Q+ ++ EE LA     LREQ Q  E
Sbjct: 2554 EARRRQHEAE-----------EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602

Query: 325  EE 326
            E+
Sbjct: 2603 EQ 2604



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/132 (25%), Positives = 65/132 (49%), Gaps = 13/132 (9%)

Query: 209  TEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRIS 268
            T+   + +EAE+QR     Q    AEAER+ L+V +++R Q +  ++ Q+ + + +  I 
Sbjct: 2361 TQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAEEDAQR-FRKQAEEIG 2414

Query: 269  EHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAP 328
            E        + +T+L  Q        ++  RQ++    E L  A  EL  + ++ ++EA 
Sbjct: 2415 EK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467

Query: 329  GLKCQVTELHDV 340
             L+ +  E+  V
Sbjct: 2468 LLQLKSEEMQTV 2479



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 77/339 (22%), Positives = 127/339 (37%), Gaps = 58/339 (17%)

Query: 28   ELRARRGSQDPRRRPAED--RAARAIQGAFRQLRARR--ELARRREERREYLE------- 76
            +LRA+  +Q P      D  R A+ +    +Q    R  E+ R RE   + LE       
Sbjct: 1134 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1193

Query: 77   QMETPQKEVEQLLTREGVGHDEAG-------EARRLQRRVALAECEDSYGNTPLSEAAAG 129
            Q +  Q+E+EQL  +     + A        +ARR Q ++      DS     + E    
Sbjct: 1194 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQ 1250

Query: 130  GQPLAIQLRAELGASPNSKGAFGPTPL-----YRAAFGGHLAAVEVLLKLGADPRVYAED 184
             Q L  ++    G        F    +     Y      + A +E +      P+V +  
Sbjct: 1251 EQALLEEIERH-GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309

Query: 185  GSTPERVASLDT---VVSVLRSWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAER 237
             S  +    L T    ++ L S  +      L+ ME E    +Q+RA+E  R + AE E 
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEA 1367

Query: 238  MTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDR 297
               K +QL     Q   + ++   EL +R+ E                + ++  EA VD 
Sbjct: 1368 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE----------------EVVRREEAAVDA 1411

Query: 298  LRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTE 336
             +Q+    EE      L+   Q+ E E +A   + +  E
Sbjct: 1412 QQQKRSIQEE------LQQLRQSSEAEIQAKARQAEAAE 1444



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 68/322 (21%), Positives = 129/322 (40%), Gaps = 33/322 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            LRA     + +R+  E+  A          R +RE A   ++R+E   ++   + E+E L
Sbjct: 1718 LRAETEQGEQQRQLLEEELA----------RLQREAAAATQKRQELEAELAKVRAEMEVL 1767

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
            L  +    +E+       ++   AE         L+E AA  + LA + + +   +   +
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRF---RELAEEAARLRALAEEAKRQRQLA--EE 1822

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV-YAEDGSTPERVASLDTVVSVLRSWDLS 207
             A              LAA+    +L  +  +   E  +  ER+  L    +  R     
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR---R 1879

Query: 208  LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKEL----------- 256
            L E   Q+ +A+ + R  + ++  ++E ER    V+   R+++Q  +E+           
Sbjct: 1880 LEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938

Query: 257  -QQAYCELS-RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARL 314
              +A  EL   RI  + +   R  ++ +L     +   A+ +R R+EA++  +    A  
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998

Query: 315  ELREQTQEGEEEAPGLKCQVTE 336
            E   Q +   EE   LK +V E
Sbjct: 1999 EAARQRKAALEEVERLKAKVEE 2020



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 3/91 (3%)

Query: 26   APELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEV 85
            A +LR  +  Q  +      R   +++ A R+     E  RR++E    L+Q+E  +++ 
Sbjct: 2527 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQ 2583

Query: 86   EQLLTREGVGHDEAGEARRLQRRVALAECED 116
            E+LL  E     E  +    Q R ALA  E+
Sbjct: 2584 EELLAEENQRLREQLQLLEEQHRAALAHSEE 2614



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 239
            SL   V ++RSW L    A  + ++ E+QR+A  + + H +A              +R+ 
Sbjct: 898  SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 953

Query: 240  LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 298
             +     RE   C    QQ    L +   E  +C+ RC+ + K + LQ        V RL
Sbjct: 954  AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 1007

Query: 299  RQEAQKAEEALAMARLELREQTQEGEEEAPG 329
            R    K E A   A+    +Q  + E E  G
Sbjct: 1008 RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1037


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 68/285 (23%), Positives = 116/285 (40%), Gaps = 19/285 (6%)

Query: 57   QLRARRELARRREERREYLEQMETPQKEVEQLL------TREGVGHDEAGEARRLQRRVA 110
            Q R + E+ RR E   +  +Q  + Q+E++QL        +      EA E  RL+    
Sbjct: 1362 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1421

Query: 111  LAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEV 170
            +         T      A G+  A++ RAE   +   +       L R          + 
Sbjct: 1422 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1481

Query: 171  LLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQ----E 226
             ++L +  RV AE  +  E+  +L  +  +         E  L+  E E+ R+ Q     
Sbjct: 1482 EVELAS--RVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALET 1537

Query: 227  AQRHKEAEAE----RMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK 282
            AQR  EAE +        K  QL R  Q+ H  + Q   E  RR  +  + E R  ++ +
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAE 1596

Query: 283  LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 327
              L+  +    +  RLR +A++  +  ++A+ E  +Q +E E EA
Sbjct: 1597 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1641



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 68/312 (21%), Positives = 134/312 (42%), Gaps = 34/312 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            L+ +    +  RR AED A       F++ R   + A+ + +  E L Q+        +L
Sbjct: 1824 LKEKEAENERLRRLAEDEA-------FQRRRLEEQAAQHKADIEERLAQLRKASDS--EL 1874

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
              ++G+  D   + R+++  +   +           +AAAG   L ++L      + ++ 
Sbjct: 1875 ERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELGRIRSNAEDTL 1927

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASLDTVVSV---- 200
             +     L  AA    LAA E   +  A+ RV     AE+ +  +R A+L+ V  +    
Sbjct: 1928 RSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1986

Query: 201  -----LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKE 255
                 LR      +   LQ  +   Q+R Q  ++      ++   ++QQ  +++Q    +
Sbjct: 1987 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2046

Query: 256  LQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLE 315
            L +   E +RR +E  + E   +   +   Q+ +  E + +RL+Q A++  +A A A+  
Sbjct: 2047 L-RGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAA 2102

Query: 316  LREQTQEGEEEA 327
              +  +E E+EA
Sbjct: 2103 AEKLRKEAEQEA 2114



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 69/304 (22%), Positives = 124/304 (40%), Gaps = 36/304 (11%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQG----AFRQLRARRELARRREERREYLEQMETPQKE 84
            LRAR    + ++R A++ A R  +     + R+ +A  ELA R +   E   + +   + 
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1505

Query: 85   VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS 144
            +E+L            +A   +RR+  AE E +       E A       +Q +    A 
Sbjct: 1506 LEELRL----------QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1555

Query: 145  PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW 204
              ++       L R+    H+A  +  L+  A+ R  A+  +  ER    +     L  W
Sbjct: 1556 KTAQ-------LERSLQEEHVAVAQ--LREEAERR--AQQQAEAERAR--EEAERELERW 1602

Query: 205  DLSLTEAM---LQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYC 261
             L   EA+   LQ  E  QQ+   +A+  K+ E      + +    EQ    +EL +   
Sbjct: 1603 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1662

Query: 262  ELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQ 321
            E  R+++E    +    ++  + L+      A+ ++  Q+ Q  EE LA  + E    TQ
Sbjct: 1663 EKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEELARLQREAAAATQ 1716

Query: 322  EGEE 325
            + +E
Sbjct: 1717 KRQE 1720



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 70/306 (22%), Positives = 126/306 (41%), Gaps = 32/306 (10%)

Query: 39   RRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQ------METPQKEVEQLLTRE 92
            RR  AE++A R  + A ++L  +R+LA    ++R   EQ       ET Q E ++ L  E
Sbjct: 1643 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1702

Query: 93   GVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 152
                    E  RLQR  A A  +       L++  A    + + L ++  A   S+    
Sbjct: 1703 --------ELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1751

Query: 153  PTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAM 212
             +     A  G       L +  A  R  AE+     ++A  D       + +  L E +
Sbjct: 1752 KSKQRLEAEAGRFRE---LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKL 1807

Query: 213  LQNMEAEQQR-RAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHD 271
                EA + +  A+ A + KEAE ER+    +    ++++  ++  Q   ++  R+++  
Sbjct: 1808 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867

Query: 272  QCEWRCMDKTK----LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLEL------REQTQ 321
            +     +++ K     TL+  +  E ++  L+   +KA    A   LEL       E T 
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1927

Query: 322  EGEEEA 327
              +E+A
Sbjct: 1928 RSKEQA 1933



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 91/416 (21%), Positives = 166/416 (39%), Gaps = 74/416 (17%)

Query: 24   LGAPELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQK 83
            L A   R     ++ RRR AE+R  ++       L A  E AR+R+   E +E+++   +
Sbjct: 1935 LEAARQRQLAAEEERRRREAEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVE 1987

Query: 84   EVEQLLTREGVGHDEAGEARRL-------QRRVALAECEDSYG----NTPLSEAAAGGQP 132
            E  +L  R      E   AR+L       Q+R+   E   ++        L +     Q 
Sbjct: 1988 EARRLRERA-----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042

Query: 133  LAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA 192
            +  QLR E  A+             RAA            +   + RV AE  +   R  
Sbjct: 2043 VLDQLRGEAEAA------------RRAA------------EEAEEARVQAEREAAQSR-R 2077

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 252
             ++    + +S +            AE+ R+  E +  + A+AE+  L+ +Q    + + 
Sbjct: 2078 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2137

Query: 253  HKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMA 312
            HK+  +       ++ +         + T L LQ +++T+ Q + L +E Q+    L   
Sbjct: 2138 HKKFAEQTLRQKAQVEQ---------ELTTLRLQ-LEETDHQKNLLDEELQR----LKAE 2183

Query: 313  RLELREQTQEGEEEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQ 372
              E   Q  + EEE   ++ Q+ EL       +  RI A+ R  L++        FL+ +
Sbjct: 2184 ATEAARQRSQVEEELFSVRVQMEEL-----SKLKARIEAENR-ALILRDKDNTQRFLQ-E 2236

Query: 373  DTNYVDTVNPEPLRPERMWLALLGALRYGKPLVFDLREEDLF--PVVQRQLEAVQE 426
            +   +  V  E     R+ +A   A R  +    DL ++      +++ +++AVQE
Sbjct: 2237 EAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2289



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 72/329 (21%), Positives = 128/329 (38%), Gaps = 43/329 (13%)

Query: 40   RRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQLLTREGVGHDEA 99
            R+ AE  AAR  Q     LR ++      E+ +++ EQ    + +VEQ LT   +  +E 
Sbjct: 2107 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2166

Query: 100  G--------EARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS------- 144
                     E +RL+     A  + S     L       + L+ +L+A + A        
Sbjct: 2167 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIEAENRALILR 2225

Query: 145  --PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR 202
               N++                 A + V  +  A  R  AE+    +R  +      +L+
Sbjct: 2226 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA----EKMLK 2281

Query: 203  SWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQ 258
                ++ EA     EAE    Q+  AQE  R  + + E+M    QQL  E Q   + L+ 
Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM---AQQLAEETQGFQRTLEA 2338

Query: 259  AYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELRE 318
                     +E ++ + R  + ++   +A +D +    R R++A++  E L    L  +E
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIGEKLHRTELATQE 2394

Query: 319  ----------QTQEGEEEAPGLKCQVTEL 337
                      Q Q+ + +A  L+  + EL
Sbjct: 2395 KVTLVQTLEIQRQQSDHDAERLREAIAEL 2423



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 67/302 (22%), Positives = 130/302 (43%), Gaps = 38/302 (12%)

Query: 49   RAIQGAFRQLRARRELARRREE-RREYLEQMETPQKEVEQLLTREGVGHDEAGEARRLQR 107
            +A+Q A R L+A  EL ++++E  +E   +++  ++++ Q L  E  G     EA R ++
Sbjct: 2285 QAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2343

Query: 108  RVALAECED-SYGNTPLSEAAAGGQPLAIQLRA---ELGA-------SPNSKGAFGPTPL 156
                AE E        +S A A  +  A + R    E+G        +   K     T  
Sbjct: 2344 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2403

Query: 157  YRAAFGGHLAAV--EVLLKLGADP----------RVYAEDGSTPERVASLDTVVSVLRSW 204
             +     H A    E + +L  +           ++ +E+  T ++   L    ++ +S+
Sbjct: 2404 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2463

Query: 205  DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS 264
             LS  +++LQ     +Q +A+  Q  ++  A+   L+ +Q  R+QQQ  +E Q+    + 
Sbjct: 2464 -LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASME 2521

Query: 265  RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 324
                   + E           + ++  + ++ +L Q+ ++ EE LA     LREQ Q  E
Sbjct: 2522 EARRRQHEAE-----------EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2570

Query: 325  EE 326
            E+
Sbjct: 2571 EQ 2572



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/132 (25%), Positives = 65/132 (49%), Gaps = 13/132 (9%)

Query: 209  TEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRIS 268
            T+   + +EAE+QR     Q    AEAER+ L+V +++R Q +  ++ Q+ + + +  I 
Sbjct: 2329 TQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAEEDAQR-FRKQAEEIG 2382

Query: 269  EHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAP 328
            E        + +T+L  Q        ++  RQ++    E L  A  EL  + ++ ++EA 
Sbjct: 2383 EK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2435

Query: 329  GLKCQVTELHDV 340
             L+ +  E+  V
Sbjct: 2436 LLQLKSEEMQTV 2447



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 77/339 (22%), Positives = 127/339 (37%), Gaps = 58/339 (17%)

Query: 28   ELRARRGSQDPRRRPAED--RAARAIQGAFRQLRARR--ELARRREERREYLE------- 76
            +LRA+  +Q P      D  R A+ +    +Q    R  E+ R RE   + LE       
Sbjct: 1102 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1161

Query: 77   QMETPQKEVEQLLTREGVGHDEAG-------EARRLQRRVALAECEDSYGNTPLSEAAAG 129
            Q +  Q+E+EQL  +     + A        +ARR Q ++      DS     + E    
Sbjct: 1162 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQ 1218

Query: 130  GQPLAIQLRAELGASPNSKGAFGPTPL-----YRAAFGGHLAAVEVLLKLGADPRVYAED 184
             Q L  ++    G        F    +     Y      + A +E +      P+V +  
Sbjct: 1219 EQALLEEIERH-GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1277

Query: 185  GSTPERVASLDT---VVSVLRSWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAER 237
             S  +    L T    ++ L S  +      L+ ME E    +Q+RA+E  R + AE E 
Sbjct: 1278 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEA 1335

Query: 238  MTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDR 297
               K +QL     Q   + ++   EL +R+ E                + ++  EA VD 
Sbjct: 1336 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE----------------EVVRREEAAVDA 1379

Query: 298  LRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTE 336
             +Q+    EE      L+   Q+ E E +A   + +  E
Sbjct: 1380 QQQKRSIQEE------LQQLRQSSEAEIQAKARQAEAAE 1412



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 68/322 (21%), Positives = 129/322 (40%), Gaps = 33/322 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            LRA     + +R+  E+  A          R +RE A   ++R+E   ++   + E+E L
Sbjct: 1686 LRAETEQGEQQRQLLEEELA----------RLQREAAAATQKRQELEAELAKVRAEMEVL 1735

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
            L  +    +E+       ++   AE         L+E AA  + LA + + +   +   +
Sbjct: 1736 LASKARAEEESRSTSEKSKQRLEAEAGRF---RELAEEAARLRALAEEAKRQRQLA--EE 1790

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV-YAEDGSTPERVASLDTVVSVLRSWDLS 207
             A              LAA+    +L  +  +   E  +  ER+  L    +  R     
Sbjct: 1791 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR---R 1847

Query: 208  LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKEL----------- 256
            L E   Q+ +A+ + R  + ++  ++E ER    V+   R+++Q  +E+           
Sbjct: 1848 LEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1906

Query: 257  -QQAYCELS-RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARL 314
              +A  EL   RI  + +   R  ++ +L     +   A+ +R R+EA++  +    A  
Sbjct: 1907 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1966

Query: 315  ELREQTQEGEEEAPGLKCQVTE 336
            E   Q +   EE   LK +V E
Sbjct: 1967 EAARQRKAALEEVERLKAKVEE 1988



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 3/91 (3%)

Query: 26   APELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEV 85
            A +LR  +  Q  +      R   +++ A R+     E  RR++E    L+Q+E  +++ 
Sbjct: 2495 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQ 2551

Query: 86   EQLLTREGVGHDEAGEARRLQRRVALAECED 116
            E+LL  E     E  +    Q R ALA  E+
Sbjct: 2552 EELLAEENQRLREQLQLLEEQHRAALAHSEE 2582



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 239
            SL   V ++RSW L    A  + ++ E+QR+A  + + H +A              +R+ 
Sbjct: 866  SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 921

Query: 240  LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 298
             +     RE   C    QQ    L +   E  +C+ RC+ + K + LQ        V RL
Sbjct: 922  AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 975

Query: 299  RQEAQKAEEALAMARLELREQTQEGEEEAPG 329
            R    K E A   A+    +Q  + E E  G
Sbjct: 976  RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1005


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 68/285 (23%), Positives = 116/285 (40%), Gaps = 19/285 (6%)

Query: 57   QLRARRELARRREERREYLEQMETPQKEVEQLL------TREGVGHDEAGEARRLQRRVA 110
            Q R + E+ RR E   +  +Q  + Q+E++QL        +      EA E  RL+    
Sbjct: 1531 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1590

Query: 111  LAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEV 170
            +         T      A G+  A++ RAE   +   +       L R          + 
Sbjct: 1591 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1650

Query: 171  LLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQ----E 226
             ++L +  RV AE  +  E+  +L  +  +         E  L+  E E+ R+ Q     
Sbjct: 1651 EVELAS--RVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALET 1706

Query: 227  AQRHKEAEAE----RMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK 282
            AQR  EAE +        K  QL R  Q+ H  + Q   E  RR  +  + E R  ++ +
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAE 1765

Query: 283  LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 327
              L+  +    +  RLR +A++  +  ++A+ E  +Q +E E EA
Sbjct: 1766 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1810



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 68/312 (21%), Positives = 134/312 (42%), Gaps = 34/312 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            L+ +    +  RR AED A       F++ R   + A+ + +  E L Q+        +L
Sbjct: 1993 LKEKEAENERLRRLAEDEA-------FQRRRLEEQAAQHKADIEERLAQLRKASDS--EL 2043

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
              ++G+  D   + R+++  +   +           +AAAG   L ++L      + ++ 
Sbjct: 2044 ERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELGRIRSNAEDTL 2096

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASLDTVVSV---- 200
             +     L  AA    LAA E   +  A+ RV     AE+ +  +R A+L+ V  +    
Sbjct: 2097 RSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2155

Query: 201  -----LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKE 255
                 LR      +   LQ  +   Q+R Q  ++      ++   ++QQ  +++Q    +
Sbjct: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215

Query: 256  LQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLE 315
            L +   E +RR +E  + E   +   +   Q+ +  E + +RL+Q A++  +A A A+  
Sbjct: 2216 L-RGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAA 2271

Query: 316  LREQTQEGEEEA 327
              +  +E E+EA
Sbjct: 2272 AEKLRKEAEQEA 2283



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 69/304 (22%), Positives = 124/304 (40%), Gaps = 36/304 (11%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQG----AFRQLRARRELARRREERREYLEQMETPQKE 84
            LRAR    + ++R A++ A R  +     + R+ +A  ELA R +   E   + +   + 
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674

Query: 85   VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS 144
            +E+L            +A   +RR+  AE E +       E A       +Q +    A 
Sbjct: 1675 LEELRL----------QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1724

Query: 145  PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW 204
              ++       L R+    H+A  +  L+  A+ R  A+  +  ER    +     L  W
Sbjct: 1725 KTAQ-------LERSLQEEHVAVAQ--LREEAERR--AQQQAEAERAR--EEAERELERW 1771

Query: 205  DLSLTEAM---LQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYC 261
             L   EA+   LQ  E  QQ+   +A+  K+ E      + +    EQ    +EL +   
Sbjct: 1772 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1831

Query: 262  ELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQ 321
            E  R+++E    +    ++  + L+      A+ ++  Q+ Q  EE LA  + E    TQ
Sbjct: 1832 EKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEELARLQREAAAATQ 1885

Query: 322  EGEE 325
            + +E
Sbjct: 1886 KRQE 1889



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 70/306 (22%), Positives = 126/306 (41%), Gaps = 32/306 (10%)

Query: 39   RRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQ------METPQKEVEQLLTRE 92
            RR  AE++A R  + A ++L  +R+LA    ++R   EQ       ET Q E ++ L  E
Sbjct: 1812 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1871

Query: 93   GVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 152
                    E  RLQR  A A  +       L++  A    + + L ++  A   S+    
Sbjct: 1872 --------ELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1920

Query: 153  PTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAM 212
             +     A  G       L +  A  R  AE+     ++A  D       + +  L E +
Sbjct: 1921 KSKQRLEAEAGRFRE---LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKL 1976

Query: 213  LQNMEAEQQR-RAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHD 271
                EA + +  A+ A + KEAE ER+    +    ++++  ++  Q   ++  R+++  
Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036

Query: 272  QCEWRCMDKTK----LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLEL------REQTQ 321
            +     +++ K     TL+  +  E ++  L+   +KA    A   LEL       E T 
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 2096

Query: 322  EGEEEA 327
              +E+A
Sbjct: 2097 RSKEQA 2102



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 91/416 (21%), Positives = 166/416 (39%), Gaps = 74/416 (17%)

Query: 24   LGAPELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQK 83
            L A   R     ++ RRR AE+R  ++       L A  E AR+R+   E +E+++   +
Sbjct: 2104 LEAARQRQLAAEEERRRREAEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVE 2156

Query: 84   EVEQLLTREGVGHDEAGEARRL-------QRRVALAECEDSYG----NTPLSEAAAGGQP 132
            E  +L  R      E   AR+L       Q+R+   E   ++        L +     Q 
Sbjct: 2157 EARRLRERA-----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211

Query: 133  LAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA 192
            +  QLR E  A+             RAA            +   + RV AE  +   R  
Sbjct: 2212 VLDQLRGEAEAA------------RRAA------------EEAEEARVQAEREAAQSR-R 2246

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 252
             ++    + +S +            AE+ R+  E +  + A+AE+  L+ +Q    + + 
Sbjct: 2247 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2306

Query: 253  HKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMA 312
            HK+  +       ++ +         + T L LQ +++T+ Q + L +E Q+    L   
Sbjct: 2307 HKKFAEQTLRQKAQVEQ---------ELTTLRLQ-LEETDHQKNLLDEELQR----LKAE 2352

Query: 313  RLELREQTQEGEEEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQ 372
              E   Q  + EEE   ++ Q+ EL       +  RI A+ R  L++        FL+ +
Sbjct: 2353 ATEAARQRSQVEEELFSVRVQMEEL-----SKLKARIEAENR-ALILRDKDNTQRFLQ-E 2405

Query: 373  DTNYVDTVNPEPLRPERMWLALLGALRYGKPLVFDLREEDLF--PVVQRQLEAVQE 426
            +   +  V  E     R+ +A   A R  +    DL ++      +++ +++AVQE
Sbjct: 2406 EAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2458



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 72/329 (21%), Positives = 128/329 (38%), Gaps = 43/329 (13%)

Query: 40   RRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQLLTREGVGHDEA 99
            R+ AE  AAR  Q     LR ++      E+ +++ EQ    + +VEQ LT   +  +E 
Sbjct: 2276 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2335

Query: 100  G--------EARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS------- 144
                     E +RL+     A  + S     L       + L+ +L+A + A        
Sbjct: 2336 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIEAENRALILR 2394

Query: 145  --PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR 202
               N++                 A + V  +  A  R  AE+    +R  +      +L+
Sbjct: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA----EKMLK 2450

Query: 203  SWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQ 258
                ++ EA     EAE    Q+  AQE  R  + + E+M    QQL  E Q   + L+ 
Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM---AQQLAEETQGFQRTLEA 2507

Query: 259  AYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELRE 318
                     +E ++ + R  + ++   +A +D +    R R++A++  E L    L  +E
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIGEKLHRTELATQE 2563

Query: 319  ----------QTQEGEEEAPGLKCQVTEL 337
                      Q Q+ + +A  L+  + EL
Sbjct: 2564 KVTLVQTLEIQRQQSDHDAERLREAIAEL 2592



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 67/302 (22%), Positives = 130/302 (43%), Gaps = 38/302 (12%)

Query: 49   RAIQGAFRQLRARRELARRREE-RREYLEQMETPQKEVEQLLTREGVGHDEAGEARRLQR 107
            +A+Q A R L+A  EL ++++E  +E   +++  ++++ Q L  E  G     EA R ++
Sbjct: 2454 QAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2512

Query: 108  RVALAECED-SYGNTPLSEAAAGGQPLAIQLRA---ELGA-------SPNSKGAFGPTPL 156
                AE E        +S A A  +  A + R    E+G        +   K     T  
Sbjct: 2513 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2572

Query: 157  YRAAFGGHLAAV--EVLLKLGADP----------RVYAEDGSTPERVASLDTVVSVLRSW 204
             +     H A    E + +L  +           ++ +E+  T ++   L    ++ +S+
Sbjct: 2573 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2632

Query: 205  DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS 264
             LS  +++LQ     +Q +A+  Q  ++  A+   L+ +Q  R+QQQ  +E Q+    + 
Sbjct: 2633 -LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASME 2690

Query: 265  RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 324
                   + E           + ++  + ++ +L Q+ ++ EE LA     LREQ Q  E
Sbjct: 2691 EARRRQHEAE-----------EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2739

Query: 325  EE 326
            E+
Sbjct: 2740 EQ 2741



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/132 (25%), Positives = 65/132 (49%), Gaps = 13/132 (9%)

Query: 209  TEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRIS 268
            T+   + +EAE+QR     Q    AEAER+ L+V +++R Q +  ++ Q+ + + +  I 
Sbjct: 2498 TQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAEEDAQR-FRKQAEEIG 2551

Query: 269  EHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAP 328
            E        + +T+L  Q        ++  RQ++    E L  A  EL  + ++ ++EA 
Sbjct: 2552 EK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2604

Query: 329  GLKCQVTELHDV 340
             L+ +  E+  V
Sbjct: 2605 LLQLKSEEMQTV 2616



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 77/339 (22%), Positives = 127/339 (37%), Gaps = 58/339 (17%)

Query: 28   ELRARRGSQDPRRRPAED--RAARAIQGAFRQLRARR--ELARRREERREYLE------- 76
            +LRA+  +Q P      D  R A+ +    +Q    R  E+ R RE   + LE       
Sbjct: 1271 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1330

Query: 77   QMETPQKEVEQLLTREGVGHDEAG-------EARRLQRRVALAECEDSYGNTPLSEAAAG 129
            Q +  Q+E+EQL  +     + A        +ARR Q ++      DS     + E    
Sbjct: 1331 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQ 1387

Query: 130  GQPLAIQLRAELGASPNSKGAFGPTPL-----YRAAFGGHLAAVEVLLKLGADPRVYAED 184
             Q L  ++    G        F    +     Y      + A +E +      P+V +  
Sbjct: 1388 EQALLEEIERH-GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1446

Query: 185  GSTPERVASLDT---VVSVLRSWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAER 237
             S  +    L T    ++ L S  +      L+ ME E    +Q+RA+E  R + AE E 
Sbjct: 1447 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEA 1504

Query: 238  MTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDR 297
               K +QL     Q   + ++   EL +R+ E                + ++  EA VD 
Sbjct: 1505 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE----------------EVVRREEAAVDA 1548

Query: 298  LRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTE 336
             +Q+    EE      L+   Q+ E E +A   + +  E
Sbjct: 1549 QQQKRSIQEE------LQQLRQSSEAEIQAKARQAEAAE 1581



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 68/322 (21%), Positives = 129/322 (40%), Gaps = 33/322 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            LRA     + +R+  E+  A          R +RE A   ++R+E   ++   + E+E L
Sbjct: 1855 LRAETEQGEQQRQLLEEELA----------RLQREAAAATQKRQELEAELAKVRAEMEVL 1904

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
            L  +    +E+       ++   AE         L+E AA  + LA + + +   +   +
Sbjct: 1905 LASKARAEEESRSTSEKSKQRLEAEAGRF---RELAEEAARLRALAEEAKRQRQLA--EE 1959

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV-YAEDGSTPERVASLDTVVSVLRSWDLS 207
             A              LAA+    +L  +  +   E  +  ER+  L    +  R     
Sbjct: 1960 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR---R 2016

Query: 208  LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKEL----------- 256
            L E   Q+ +A+ + R  + ++  ++E ER    V+   R+++Q  +E+           
Sbjct: 2017 LEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 2075

Query: 257  -QQAYCELS-RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARL 314
              +A  EL   RI  + +   R  ++ +L     +   A+ +R R+EA++  +    A  
Sbjct: 2076 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2135

Query: 315  ELREQTQEGEEEAPGLKCQVTE 336
            E   Q +   EE   LK +V E
Sbjct: 2136 EAARQRKAALEEVERLKAKVEE 2157



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 3/91 (3%)

Query: 26   APELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEV 85
            A +LR  +  Q  +      R   +++ A R+     E  RR++E    L+Q+E  +++ 
Sbjct: 2664 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQ 2720

Query: 86   EQLLTREGVGHDEAGEARRLQRRVALAECED 116
            E+LL  E     E  +    Q R ALA  E+
Sbjct: 2721 EELLAEENQRLREQLQLLEEQHRAALAHSEE 2751



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 239
            SL   V ++RSW L    A  + ++ E+QR+A  + + H +A              +R+ 
Sbjct: 1035 SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 1090

Query: 240  LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 298
             +     RE   C    QQ    L +   E  +C+ RC+ + K + LQ        V RL
Sbjct: 1091 AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 1144

Query: 299  RQEAQKAEEALAMARLELREQTQEGEEEAPG 329
            R    K E A   A+    +Q  + E E  G
Sbjct: 1145 RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1174


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 68/285 (23%), Positives = 116/285 (40%), Gaps = 19/285 (6%)

Query: 57   QLRARRELARRREERREYLEQMETPQKEVEQLL------TREGVGHDEAGEARRLQRRVA 110
            Q R + E+ RR E   +  +Q  + Q+E++QL        +      EA E  RL+    
Sbjct: 1372 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1431

Query: 111  LAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEV 170
            +         T      A G+  A++ RAE   +   +       L R          + 
Sbjct: 1432 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1491

Query: 171  LLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQ----E 226
             ++L +  RV AE  +  E+  +L  +  +         E  L+  E E+ R+ Q     
Sbjct: 1492 EVELAS--RVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALET 1547

Query: 227  AQRHKEAEAE----RMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK 282
            AQR  EAE +        K  QL R  Q+ H  + Q   E  RR  +  + E R  ++ +
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAE 1606

Query: 283  LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 327
              L+  +    +  RLR +A++  +  ++A+ E  +Q +E E EA
Sbjct: 1607 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1651



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 68/312 (21%), Positives = 134/312 (42%), Gaps = 34/312 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            L+ +    +  RR AED A       F++ R   + A+ + +  E L Q+        +L
Sbjct: 1834 LKEKEAENERLRRLAEDEA-------FQRRRLEEQAAQHKADIEERLAQLRKASDS--EL 1884

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
              ++G+  D   + R+++  +   +           +AAAG   L ++L      + ++ 
Sbjct: 1885 ERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELGRIRSNAEDTL 1937

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASLDTVVSV---- 200
             +     L  AA    LAA E   +  A+ RV     AE+ +  +R A+L+ V  +    
Sbjct: 1938 RSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1996

Query: 201  -----LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKE 255
                 LR      +   LQ  +   Q+R Q  ++      ++   ++QQ  +++Q    +
Sbjct: 1997 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056

Query: 256  LQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLE 315
            L +   E +RR +E  + E   +   +   Q+ +  E + +RL+Q A++  +A A A+  
Sbjct: 2057 L-RGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAA 2112

Query: 316  LREQTQEGEEEA 327
              +  +E E+EA
Sbjct: 2113 AEKLRKEAEQEA 2124



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 69/304 (22%), Positives = 124/304 (40%), Gaps = 36/304 (11%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQG----AFRQLRARRELARRREERREYLEQMETPQKE 84
            LRAR    + ++R A++ A R  +     + R+ +A  ELA R +   E   + +   + 
Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1515

Query: 85   VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS 144
            +E+L            +A   +RR+  AE E +       E A       +Q +    A 
Sbjct: 1516 LEELRL----------QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1565

Query: 145  PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW 204
              ++       L R+    H+A  +  L+  A+ R  A+  +  ER    +     L  W
Sbjct: 1566 KTAQ-------LERSLQEEHVAVAQ--LREEAERR--AQQQAEAERAR--EEAERELERW 1612

Query: 205  DLSLTEAM---LQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYC 261
             L   EA+   LQ  E  QQ+   +A+  K+ E      + +    EQ    +EL +   
Sbjct: 1613 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1672

Query: 262  ELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQ 321
            E  R+++E    +    ++  + L+      A+ ++  Q+ Q  EE LA  + E    TQ
Sbjct: 1673 EKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEELARLQREAAAATQ 1726

Query: 322  EGEE 325
            + +E
Sbjct: 1727 KRQE 1730



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 70/306 (22%), Positives = 126/306 (41%), Gaps = 32/306 (10%)

Query: 39   RRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQ------METPQKEVEQLLTRE 92
            RR  AE++A R  + A ++L  +R+LA    ++R   EQ       ET Q E ++ L  E
Sbjct: 1653 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1712

Query: 93   GVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 152
                    E  RLQR  A A  +       L++  A    + + L ++  A   S+    
Sbjct: 1713 --------ELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1761

Query: 153  PTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAM 212
             +     A  G       L +  A  R  AE+     ++A  D       + +  L E +
Sbjct: 1762 KSKQRLEAEAGRFRE---LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKL 1817

Query: 213  LQNMEAEQQR-RAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHD 271
                EA + +  A+ A + KEAE ER+    +    ++++  ++  Q   ++  R+++  
Sbjct: 1818 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877

Query: 272  QCEWRCMDKTK----LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLEL------REQTQ 321
            +     +++ K     TL+  +  E ++  L+   +KA    A   LEL       E T 
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1937

Query: 322  EGEEEA 327
              +E+A
Sbjct: 1938 RSKEQA 1943



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 91/416 (21%), Positives = 166/416 (39%), Gaps = 74/416 (17%)

Query: 24   LGAPELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQK 83
            L A   R     ++ RRR AE+R  ++       L A  E AR+R+   E +E+++   +
Sbjct: 1945 LEAARQRQLAAEEERRRREAEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVE 1997

Query: 84   EVEQLLTREGVGHDEAGEARRL-------QRRVALAECEDSYG----NTPLSEAAAGGQP 132
            E  +L  R      E   AR+L       Q+R+   E   ++        L +     Q 
Sbjct: 1998 EARRLRERA-----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052

Query: 133  LAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA 192
            +  QLR E  A+             RAA            +   + RV AE  +   R  
Sbjct: 2053 VLDQLRGEAEAA------------RRAA------------EEAEEARVQAEREAAQSR-R 2087

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 252
             ++    + +S +            AE+ R+  E +  + A+AE+  L+ +Q    + + 
Sbjct: 2088 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2147

Query: 253  HKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMA 312
            HK+  +       ++ +         + T L LQ +++T+ Q + L +E Q+    L   
Sbjct: 2148 HKKFAEQTLRQKAQVEQ---------ELTTLRLQ-LEETDHQKNLLDEELQR----LKAE 2193

Query: 313  RLELREQTQEGEEEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQ 372
              E   Q  + EEE   ++ Q+ EL       +  RI A+ R  L++        FL+ +
Sbjct: 2194 ATEAARQRSQVEEELFSVRVQMEEL-----SKLKARIEAENR-ALILRDKDNTQRFLQ-E 2246

Query: 373  DTNYVDTVNPEPLRPERMWLALLGALRYGKPLVFDLREEDLF--PVVQRQLEAVQE 426
            +   +  V  E     R+ +A   A R  +    DL ++      +++ +++AVQE
Sbjct: 2247 EAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2299



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 72/329 (21%), Positives = 128/329 (38%), Gaps = 43/329 (13%)

Query: 40   RRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQLLTREGVGHDEA 99
            R+ AE  AAR  Q     LR ++      E+ +++ EQ    + +VEQ LT   +  +E 
Sbjct: 2117 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2176

Query: 100  G--------EARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS------- 144
                     E +RL+     A  + S     L       + L+ +L+A + A        
Sbjct: 2177 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIEAENRALILR 2235

Query: 145  --PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR 202
               N++                 A + V  +  A  R  AE+    +R  +      +L+
Sbjct: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA----EKMLK 2291

Query: 203  SWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQ 258
                ++ EA     EAE    Q+  AQE  R  + + E+M    QQL  E Q   + L+ 
Sbjct: 2292 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM---AQQLAEETQGFQRTLEA 2348

Query: 259  AYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELRE 318
                     +E ++ + R  + ++   +A +D +    R R++A++  E L    L  +E
Sbjct: 2349 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIGEKLHRTELATQE 2404

Query: 319  ----------QTQEGEEEAPGLKCQVTEL 337
                      Q Q+ + +A  L+  + EL
Sbjct: 2405 KVTLVQTLEIQRQQSDHDAERLREAIAEL 2433



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 67/302 (22%), Positives = 130/302 (43%), Gaps = 38/302 (12%)

Query: 49   RAIQGAFRQLRARRELARRREE-RREYLEQMETPQKEVEQLLTREGVGHDEAGEARRLQR 107
            +A+Q A R L+A  EL ++++E  +E   +++  ++++ Q L  E  G     EA R ++
Sbjct: 2295 QAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2353

Query: 108  RVALAECED-SYGNTPLSEAAAGGQPLAIQLRA---ELGA-------SPNSKGAFGPTPL 156
                AE E        +S A A  +  A + R    E+G        +   K     T  
Sbjct: 2354 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2413

Query: 157  YRAAFGGHLAAV--EVLLKLGADP----------RVYAEDGSTPERVASLDTVVSVLRSW 204
             +     H A    E + +L  +           ++ +E+  T ++   L    ++ +S+
Sbjct: 2414 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2473

Query: 205  DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS 264
             LS  +++LQ     +Q +A+  Q  ++  A+   L+ +Q  R+QQQ  +E Q+    + 
Sbjct: 2474 -LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASME 2531

Query: 265  RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 324
                   + E           + ++  + ++ +L Q+ ++ EE LA     LREQ Q  E
Sbjct: 2532 EARRRQHEAE-----------EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2580

Query: 325  EE 326
            E+
Sbjct: 2581 EQ 2582



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/132 (25%), Positives = 65/132 (49%), Gaps = 13/132 (9%)

Query: 209  TEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRIS 268
            T+   + +EAE+QR     Q    AEAER+ L+V +++R Q +  ++ Q+ + + +  I 
Sbjct: 2339 TQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAEEDAQR-FRKQAEEIG 2392

Query: 269  EHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAP 328
            E        + +T+L  Q        ++  RQ++    E L  A  EL  + ++ ++EA 
Sbjct: 2393 EK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2445

Query: 329  GLKCQVTELHDV 340
             L+ +  E+  V
Sbjct: 2446 LLQLKSEEMQTV 2457



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 77/339 (22%), Positives = 127/339 (37%), Gaps = 58/339 (17%)

Query: 28   ELRARRGSQDPRRRPAED--RAARAIQGAFRQLRARR--ELARRREERREYLE------- 76
            +LRA+  +Q P      D  R A+ +    +Q    R  E+ R RE   + LE       
Sbjct: 1112 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1171

Query: 77   QMETPQKEVEQLLTREGVGHDEAG-------EARRLQRRVALAECEDSYGNTPLSEAAAG 129
            Q +  Q+E+EQL  +     + A        +ARR Q ++      DS     + E    
Sbjct: 1172 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQ 1228

Query: 130  GQPLAIQLRAELGASPNSKGAFGPTPL-----YRAAFGGHLAAVEVLLKLGADPRVYAED 184
             Q L  ++    G        F    +     Y      + A +E +      P+V +  
Sbjct: 1229 EQALLEEIERH-GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1287

Query: 185  GSTPERVASLDT---VVSVLRSWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAER 237
             S  +    L T    ++ L S  +      L+ ME E    +Q+RA+E  R + AE E 
Sbjct: 1288 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEA 1345

Query: 238  MTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDR 297
               K +QL     Q   + ++   EL +R+ E                + ++  EA VD 
Sbjct: 1346 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE----------------EVVRREEAAVDA 1389

Query: 298  LRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTE 336
             +Q+    EE      L+   Q+ E E +A   + +  E
Sbjct: 1390 QQQKRSIQEE------LQQLRQSSEAEIQAKARQAEAAE 1422



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 68/322 (21%), Positives = 129/322 (40%), Gaps = 33/322 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            LRA     + +R+  E+  A          R +RE A   ++R+E   ++   + E+E L
Sbjct: 1696 LRAETEQGEQQRQLLEEELA----------RLQREAAAATQKRQELEAELAKVRAEMEVL 1745

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
            L  +    +E+       ++   AE         L+E AA  + LA + + +   +   +
Sbjct: 1746 LASKARAEEESRSTSEKSKQRLEAEAGRF---RELAEEAARLRALAEEAKRQRQLA--EE 1800

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV-YAEDGSTPERVASLDTVVSVLRSWDLS 207
             A              LAA+    +L  +  +   E  +  ER+  L    +  R     
Sbjct: 1801 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR---R 1857

Query: 208  LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKEL----------- 256
            L E   Q+ +A+ + R  + ++  ++E ER    V+   R+++Q  +E+           
Sbjct: 1858 LEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1916

Query: 257  -QQAYCELS-RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARL 314
              +A  EL   RI  + +   R  ++ +L     +   A+ +R R+EA++  +    A  
Sbjct: 1917 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1976

Query: 315  ELREQTQEGEEEAPGLKCQVTE 336
            E   Q +   EE   LK +V E
Sbjct: 1977 EAARQRKAALEEVERLKAKVEE 1998



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 3/91 (3%)

Query: 26   APELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEV 85
            A +LR  +  Q  +      R   +++ A R+     E  RR++E    L+Q+E  +++ 
Sbjct: 2505 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQ 2561

Query: 86   EQLLTREGVGHDEAGEARRLQRRVALAECED 116
            E+LL  E     E  +    Q R ALA  E+
Sbjct: 2562 EELLAEENQRLREQLQLLEEQHRAALAHSEE 2592



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 239
            SL   V ++RSW L    A  + ++ E+QR+A  + + H +A              +R+ 
Sbjct: 876  SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 931

Query: 240  LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 298
             +     RE   C    QQ    L +   E  +C+ RC+ + K + LQ        V RL
Sbjct: 932  AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 985

Query: 299  RQEAQKAEEALAMARLELREQTQEGEEEAPG 329
            R    K E A   A+    +Q  + E E  G
Sbjct: 986  RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1015


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 68/285 (23%), Positives = 116/285 (40%), Gaps = 19/285 (6%)

Query: 57   QLRARRELARRREERREYLEQMETPQKEVEQLL------TREGVGHDEAGEARRLQRRVA 110
            Q R + E+ RR E   +  +Q  + Q+E++QL        +      EA E  RL+    
Sbjct: 1380 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1439

Query: 111  LAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEV 170
            +         T      A G+  A++ RAE   +   +       L R          + 
Sbjct: 1440 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1499

Query: 171  LLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQ----E 226
             ++L +  RV AE  +  E+  +L  +  +         E  L+  E E+ R+ Q     
Sbjct: 1500 EVELAS--RVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALET 1555

Query: 227  AQRHKEAEAE----RMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK 282
            AQR  EAE +        K  QL R  Q+ H  + Q   E  RR  +  + E R  ++ +
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAE 1614

Query: 283  LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 327
              L+  +    +  RLR +A++  +  ++A+ E  +Q +E E EA
Sbjct: 1615 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1659



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 68/312 (21%), Positives = 134/312 (42%), Gaps = 34/312 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            L+ +    +  RR AED A       F++ R   + A+ + +  E L Q+        +L
Sbjct: 1842 LKEKEAENERLRRLAEDEA-------FQRRRLEEQAAQHKADIEERLAQLRKASDS--EL 1892

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
              ++G+  D   + R+++  +   +           +AAAG   L ++L      + ++ 
Sbjct: 1893 ERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELGRIRSNAEDTL 1945

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASLDTVVSV---- 200
             +     L  AA    LAA E   +  A+ RV     AE+ +  +R A+L+ V  +    
Sbjct: 1946 RSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2004

Query: 201  -----LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKE 255
                 LR      +   LQ  +   Q+R Q  ++      ++   ++QQ  +++Q    +
Sbjct: 2005 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2064

Query: 256  LQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLE 315
            L +   E +RR +E  + E   +   +   Q+ +  E + +RL+Q A++  +A A A+  
Sbjct: 2065 L-RGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAA 2120

Query: 316  LREQTQEGEEEA 327
              +  +E E+EA
Sbjct: 2121 AEKLRKEAEQEA 2132



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 69/304 (22%), Positives = 124/304 (40%), Gaps = 36/304 (11%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQG----AFRQLRARRELARRREERREYLEQMETPQKE 84
            LRAR    + ++R A++ A R  +     + R+ +A  ELA R +   E   + +   + 
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1523

Query: 85   VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS 144
            +E+L            +A   +RR+  AE E +       E A       +Q +    A 
Sbjct: 1524 LEELRL----------QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1573

Query: 145  PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW 204
              ++       L R+    H+A  +  L+  A+ R  A+  +  ER    +     L  W
Sbjct: 1574 KTAQ-------LERSLQEEHVAVAQ--LREEAERR--AQQQAEAERAR--EEAERELERW 1620

Query: 205  DLSLTEAM---LQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYC 261
             L   EA+   LQ  E  QQ+   +A+  K+ E      + +    EQ    +EL +   
Sbjct: 1621 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1680

Query: 262  ELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQ 321
            E  R+++E    +    ++  + L+      A+ ++  Q+ Q  EE LA  + E    TQ
Sbjct: 1681 EKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEELARLQREAAAATQ 1734

Query: 322  EGEE 325
            + +E
Sbjct: 1735 KRQE 1738



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 70/306 (22%), Positives = 126/306 (41%), Gaps = 32/306 (10%)

Query: 39   RRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQ------METPQKEVEQLLTRE 92
            RR  AE++A R  + A ++L  +R+LA    ++R   EQ       ET Q E ++ L  E
Sbjct: 1661 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1720

Query: 93   GVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 152
                    E  RLQR  A A  +       L++  A    + + L ++  A   S+    
Sbjct: 1721 --------ELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1769

Query: 153  PTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAM 212
             +     A  G       L +  A  R  AE+     ++A  D       + +  L E +
Sbjct: 1770 KSKQRLEAEAGRFRE---LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKL 1825

Query: 213  LQNMEAEQQR-RAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHD 271
                EA + +  A+ A + KEAE ER+    +    ++++  ++  Q   ++  R+++  
Sbjct: 1826 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1885

Query: 272  QCEWRCMDKTK----LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLEL------REQTQ 321
            +     +++ K     TL+  +  E ++  L+   +KA    A   LEL       E T 
Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1945

Query: 322  EGEEEA 327
              +E+A
Sbjct: 1946 RSKEQA 1951



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 91/416 (21%), Positives = 166/416 (39%), Gaps = 74/416 (17%)

Query: 24   LGAPELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQK 83
            L A   R     ++ RRR AE+R  ++       L A  E AR+R+   E +E+++   +
Sbjct: 1953 LEAARQRQLAAEEERRRREAEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVE 2005

Query: 84   EVEQLLTREGVGHDEAGEARRL-------QRRVALAECEDSYG----NTPLSEAAAGGQP 132
            E  +L  R      E   AR+L       Q+R+   E   ++        L +     Q 
Sbjct: 2006 EARRLRERA-----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2060

Query: 133  LAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA 192
            +  QLR E  A+             RAA            +   + RV AE  +   R  
Sbjct: 2061 VLDQLRGEAEAA------------RRAA------------EEAEEARVQAEREAAQSR-R 2095

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 252
             ++    + +S +            AE+ R+  E +  + A+AE+  L+ +Q    + + 
Sbjct: 2096 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2155

Query: 253  HKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMA 312
            HK+  +       ++ +         + T L LQ +++T+ Q + L +E Q+    L   
Sbjct: 2156 HKKFAEQTLRQKAQVEQ---------ELTTLRLQ-LEETDHQKNLLDEELQR----LKAE 2201

Query: 313  RLELREQTQEGEEEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQ 372
              E   Q  + EEE   ++ Q+ EL       +  RI A+ R  L++        FL+ +
Sbjct: 2202 ATEAARQRSQVEEELFSVRVQMEEL-----SKLKARIEAENR-ALILRDKDNTQRFLQ-E 2254

Query: 373  DTNYVDTVNPEPLRPERMWLALLGALRYGKPLVFDLREEDLF--PVVQRQLEAVQE 426
            +   +  V  E     R+ +A   A R  +    DL ++      +++ +++AVQE
Sbjct: 2255 EAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2307



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 72/329 (21%), Positives = 128/329 (38%), Gaps = 43/329 (13%)

Query: 40   RRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQLLTREGVGHDEA 99
            R+ AE  AAR  Q     LR ++      E+ +++ EQ    + +VEQ LT   +  +E 
Sbjct: 2125 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2184

Query: 100  G--------EARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS------- 144
                     E +RL+     A  + S     L       + L+ +L+A + A        
Sbjct: 2185 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIEAENRALILR 2243

Query: 145  --PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR 202
               N++                 A + V  +  A  R  AE+    +R  +      +L+
Sbjct: 2244 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA----EKMLK 2299

Query: 203  SWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQ 258
                ++ EA     EAE    Q+  AQE  R  + + E+M    QQL  E Q   + L+ 
Sbjct: 2300 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM---AQQLAEETQGFQRTLEA 2356

Query: 259  AYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELRE 318
                     +E ++ + R  + ++   +A +D +    R R++A++  E L    L  +E
Sbjct: 2357 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIGEKLHRTELATQE 2412

Query: 319  ----------QTQEGEEEAPGLKCQVTEL 337
                      Q Q+ + +A  L+  + EL
Sbjct: 2413 KVTLVQTLEIQRQQSDHDAERLREAIAEL 2441



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 67/302 (22%), Positives = 130/302 (43%), Gaps = 38/302 (12%)

Query: 49   RAIQGAFRQLRARRELARRREE-RREYLEQMETPQKEVEQLLTREGVGHDEAGEARRLQR 107
            +A+Q A R L+A  EL ++++E  +E   +++  ++++ Q L  E  G     EA R ++
Sbjct: 2303 QAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2361

Query: 108  RVALAECED-SYGNTPLSEAAAGGQPLAIQLRA---ELGA-------SPNSKGAFGPTPL 156
                AE E        +S A A  +  A + R    E+G        +   K     T  
Sbjct: 2362 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2421

Query: 157  YRAAFGGHLAAV--EVLLKLGADP----------RVYAEDGSTPERVASLDTVVSVLRSW 204
             +     H A    E + +L  +           ++ +E+  T ++   L    ++ +S+
Sbjct: 2422 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2481

Query: 205  DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS 264
             LS  +++LQ     +Q +A+  Q  ++  A+   L+ +Q  R+QQQ  +E Q+    + 
Sbjct: 2482 -LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASME 2539

Query: 265  RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 324
                   + E           + ++  + ++ +L Q+ ++ EE LA     LREQ Q  E
Sbjct: 2540 EARRRQHEAE-----------EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2588

Query: 325  EE 326
            E+
Sbjct: 2589 EQ 2590



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/132 (25%), Positives = 65/132 (49%), Gaps = 13/132 (9%)

Query: 209  TEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRIS 268
            T+   + +EAE+QR     Q    AEAER+ L+V +++R Q +  ++ Q+ + + +  I 
Sbjct: 2347 TQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAEEDAQR-FRKQAEEIG 2400

Query: 269  EHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAP 328
            E        + +T+L  Q        ++  RQ++    E L  A  EL  + ++ ++EA 
Sbjct: 2401 EK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2453

Query: 329  GLKCQVTELHDV 340
             L+ +  E+  V
Sbjct: 2454 LLQLKSEEMQTV 2465



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 77/339 (22%), Positives = 127/339 (37%), Gaps = 58/339 (17%)

Query: 28   ELRARRGSQDPRRRPAED--RAARAIQGAFRQLRARR--ELARRREERREYLE------- 76
            +LRA+  +Q P      D  R A+ +    +Q    R  E+ R RE   + LE       
Sbjct: 1120 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1179

Query: 77   QMETPQKEVEQLLTREGVGHDEAG-------EARRLQRRVALAECEDSYGNTPLSEAAAG 129
            Q +  Q+E+EQL  +     + A        +ARR Q ++      DS     + E    
Sbjct: 1180 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQ 1236

Query: 130  GQPLAIQLRAELGASPNSKGAFGPTPL-----YRAAFGGHLAAVEVLLKLGADPRVYAED 184
             Q L  ++    G        F    +     Y      + A +E +      P+V +  
Sbjct: 1237 EQALLEEIERH-GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1295

Query: 185  GSTPERVASLDT---VVSVLRSWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAER 237
             S  +    L T    ++ L S  +      L+ ME E    +Q+RA+E  R + AE E 
Sbjct: 1296 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEA 1353

Query: 238  MTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDR 297
               K +QL     Q   + ++   EL +R+ E                + ++  EA VD 
Sbjct: 1354 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE----------------EVVRREEAAVDA 1397

Query: 298  LRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTE 336
             +Q+    EE      L+   Q+ E E +A   + +  E
Sbjct: 1398 QQQKRSIQEE------LQQLRQSSEAEIQAKARQAEAAE 1430



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 68/322 (21%), Positives = 129/322 (40%), Gaps = 33/322 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            LRA     + +R+  E+  A          R +RE A   ++R+E   ++   + E+E L
Sbjct: 1704 LRAETEQGEQQRQLLEEELA----------RLQREAAAATQKRQELEAELAKVRAEMEVL 1753

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
            L  +    +E+       ++   AE         L+E AA  + LA + + +   +   +
Sbjct: 1754 LASKARAEEESRSTSEKSKQRLEAEAGRF---RELAEEAARLRALAEEAKRQRQLA--EE 1808

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV-YAEDGSTPERVASLDTVVSVLRSWDLS 207
             A              LAA+    +L  +  +   E  +  ER+  L    +  R     
Sbjct: 1809 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR---R 1865

Query: 208  LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKEL----------- 256
            L E   Q+ +A+ + R  + ++  ++E ER    V+   R+++Q  +E+           
Sbjct: 1866 LEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1924

Query: 257  -QQAYCELS-RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARL 314
              +A  EL   RI  + +   R  ++ +L     +   A+ +R R+EA++  +    A  
Sbjct: 1925 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1984

Query: 315  ELREQTQEGEEEAPGLKCQVTE 336
            E   Q +   EE   LK +V E
Sbjct: 1985 EAARQRKAALEEVERLKAKVEE 2006



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 3/91 (3%)

Query: 26   APELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEV 85
            A +LR  +  Q  +      R   +++ A R+     E  RR++E    L+Q+E  +++ 
Sbjct: 2513 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQ 2569

Query: 86   EQLLTREGVGHDEAGEARRLQRRVALAECED 116
            E+LL  E     E  +    Q R ALA  E+
Sbjct: 2570 EELLAEENQRLREQLQLLEEQHRAALAHSEE 2600



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 239
            SL   V ++RSW L    A  + ++ E+QR+A  + + H +A              +R+ 
Sbjct: 884  SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 939

Query: 240  LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 298
             +     RE   C    QQ    L +   E  +C+ RC+ + K + LQ        V RL
Sbjct: 940  AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 993

Query: 299  RQEAQKAEEALAMARLELREQTQEGEEEAPG 329
            R    K E A   A+    +Q  + E E  G
Sbjct: 994  RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1023


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 68/285 (23%), Positives = 116/285 (40%), Gaps = 19/285 (6%)

Query: 57   QLRARRELARRREERREYLEQMETPQKEVEQLL------TREGVGHDEAGEARRLQRRVA 110
            Q R + E+ RR E   +  +Q  + Q+E++QL        +      EA E  RL+    
Sbjct: 1421 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1480

Query: 111  LAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEV 170
            +         T      A G+  A++ RAE   +   +       L R          + 
Sbjct: 1481 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1540

Query: 171  LLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQ----E 226
             ++L +  RV AE  +  E+  +L  +  +         E  L+  E E+ R+ Q     
Sbjct: 1541 EVELAS--RVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALET 1596

Query: 227  AQRHKEAEAE----RMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK 282
            AQR  EAE +        K  QL R  Q+ H  + Q   E  RR  +  + E R  ++ +
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAE 1655

Query: 283  LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 327
              L+  +    +  RLR +A++  +  ++A+ E  +Q +E E EA
Sbjct: 1656 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1700



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 68/312 (21%), Positives = 134/312 (42%), Gaps = 34/312 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            L+ +    +  RR AED A       F++ R   + A+ + +  E L Q+        +L
Sbjct: 1883 LKEKEAENERLRRLAEDEA-------FQRRRLEEQAAQHKADIEERLAQLRKASDS--EL 1933

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
              ++G+  D   + R+++  +   +           +AAAG   L ++L      + ++ 
Sbjct: 1934 ERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELGRIRSNAEDTL 1986

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASLDTVVSV---- 200
             +     L  AA    LAA E   +  A+ RV     AE+ +  +R A+L+ V  +    
Sbjct: 1987 RSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2045

Query: 201  -----LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKE 255
                 LR      +   LQ  +   Q+R Q  ++      ++   ++QQ  +++Q    +
Sbjct: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2105

Query: 256  LQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLE 315
            L +   E +RR +E  + E   +   +   Q+ +  E + +RL+Q A++  +A A A+  
Sbjct: 2106 L-RGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAA 2161

Query: 316  LREQTQEGEEEA 327
              +  +E E+EA
Sbjct: 2162 AEKLRKEAEQEA 2173



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 69/304 (22%), Positives = 124/304 (40%), Gaps = 36/304 (11%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQG----AFRQLRARRELARRREERREYLEQMETPQKE 84
            LRAR    + ++R A++ A R  +     + R+ +A  ELA R +   E   + +   + 
Sbjct: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1564

Query: 85   VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS 144
            +E+L            +A   +RR+  AE E +       E A       +Q +    A 
Sbjct: 1565 LEELRL----------QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1614

Query: 145  PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW 204
              ++       L R+    H+A  +  L+  A+ R  A+  +  ER    +     L  W
Sbjct: 1615 KTAQ-------LERSLQEEHVAVAQ--LREEAERR--AQQQAEAERAR--EEAERELERW 1661

Query: 205  DLSLTEAM---LQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYC 261
             L   EA+   LQ  E  QQ+   +A+  K+ E      + +    EQ    +EL +   
Sbjct: 1662 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1721

Query: 262  ELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQ 321
            E  R+++E    +    ++  + L+      A+ ++  Q+ Q  EE LA  + E    TQ
Sbjct: 1722 EKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEELARLQREAAAATQ 1775

Query: 322  EGEE 325
            + +E
Sbjct: 1776 KRQE 1779



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 70/306 (22%), Positives = 126/306 (41%), Gaps = 32/306 (10%)

Query: 39   RRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQ------METPQKEVEQLLTRE 92
            RR  AE++A R  + A ++L  +R+LA    ++R   EQ       ET Q E ++ L  E
Sbjct: 1702 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1761

Query: 93   GVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 152
                    E  RLQR  A A  +       L++  A    + + L ++  A   S+    
Sbjct: 1762 --------ELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1810

Query: 153  PTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAM 212
             +     A  G       L +  A  R  AE+     ++A  D       + +  L E +
Sbjct: 1811 KSKQRLEAEAGRFRE---LAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKL 1866

Query: 213  LQNMEAEQQR-RAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHD 271
                EA + +  A+ A + KEAE ER+    +    ++++  ++  Q   ++  R+++  
Sbjct: 1867 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1926

Query: 272  QCEWRCMDKTK----LTLQAIKDTEAQVDRLRQEAQKAEEALAMARLEL------REQTQ 321
            +     +++ K     TL+  +  E ++  L+   +KA    A   LEL       E T 
Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1986

Query: 322  EGEEEA 327
              +E+A
Sbjct: 1987 RSKEQA 1992



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 91/416 (21%), Positives = 166/416 (39%), Gaps = 74/416 (17%)

Query: 24   LGAPELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQK 83
            L A   R     ++ RRR AE+R  ++       L A  E AR+R+   E +E+++   +
Sbjct: 1994 LEAARQRQLAAEEERRRREAEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVE 2046

Query: 84   EVEQLLTREGVGHDEAGEARRL-------QRRVALAECEDSYG----NTPLSEAAAGGQP 132
            E  +L  R      E   AR+L       Q+R+   E   ++        L +     Q 
Sbjct: 2047 EARRLRERA-----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2101

Query: 133  LAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA 192
            +  QLR E  A+             RAA            +   + RV AE  +   R  
Sbjct: 2102 VLDQLRGEAEAA------------RRAA------------EEAEEARVQAEREAAQSR-R 2136

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 252
             ++    + +S +            AE+ R+  E +  + A+AE+  L+ +Q    + + 
Sbjct: 2137 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2196

Query: 253  HKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMA 312
            HK+  +       ++ +         + T L LQ +++T+ Q + L +E Q+    L   
Sbjct: 2197 HKKFAEQTLRQKAQVEQ---------ELTTLRLQ-LEETDHQKNLLDEELQR----LKAE 2242

Query: 313  RLELREQTQEGEEEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQ 372
              E   Q  + EEE   ++ Q+ EL       +  RI A+ R  L++        FL+ +
Sbjct: 2243 ATEAARQRSQVEEELFSVRVQMEEL-----SKLKARIEAENR-ALILRDKDNTQRFLQ-E 2295

Query: 373  DTNYVDTVNPEPLRPERMWLALLGALRYGKPLVFDLREEDLF--PVVQRQLEAVQE 426
            +   +  V  E     R+ +A   A R  +    DL ++      +++ +++AVQE
Sbjct: 2296 EAEKMKQVAEE---AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2348



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 72/329 (21%), Positives = 128/329 (38%), Gaps = 43/329 (13%)

Query: 40   RRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQLLTREGVGHDEA 99
            R+ AE  AAR  Q     LR ++      E+ +++ EQ    + +VEQ LT   +  +E 
Sbjct: 2166 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2225

Query: 100  G--------EARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS------- 144
                     E +RL+     A  + S     L       + L+ +L+A + A        
Sbjct: 2226 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIEAENRALILR 2284

Query: 145  --PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR 202
               N++                 A + V  +  A  R  AE+    +R  +      +L+
Sbjct: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA----EKMLK 2340

Query: 203  SWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQ 258
                ++ EA     EAE    Q+  AQE  R  + + E+M    QQL  E Q   + L+ 
Sbjct: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM---AQQLAEETQGFQRTLEA 2397

Query: 259  AYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELRE 318
                     +E ++ + R  + ++   +A +D +    R R++A++  E L    L  +E
Sbjct: 2398 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIGEKLHRTELATQE 2453

Query: 319  ----------QTQEGEEEAPGLKCQVTEL 337
                      Q Q+ + +A  L+  + EL
Sbjct: 2454 KVTLVQTLEIQRQQSDHDAERLREAIAEL 2482



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 67/302 (22%), Positives = 130/302 (43%), Gaps = 38/302 (12%)

Query: 49   RAIQGAFRQLRARRELARRREE-RREYLEQMETPQKEVEQLLTREGVGHDEAGEARRLQR 107
            +A+Q A R L+A  EL ++++E  +E   +++  ++++ Q L  E  G     EA R ++
Sbjct: 2344 QAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2402

Query: 108  RVALAECED-SYGNTPLSEAAAGGQPLAIQLRA---ELGA-------SPNSKGAFGPTPL 156
                AE E        +S A A  +  A + R    E+G        +   K     T  
Sbjct: 2403 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2462

Query: 157  YRAAFGGHLAAV--EVLLKLGADP----------RVYAEDGSTPERVASLDTVVSVLRSW 204
             +     H A    E + +L  +           ++ +E+  T ++   L    ++ +S+
Sbjct: 2463 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2522

Query: 205  DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS 264
             LS  +++LQ     +Q +A+  Q  ++  A+   L+ +Q  R+QQQ  +E Q+    + 
Sbjct: 2523 -LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASME 2580

Query: 265  RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 324
                   + E           + ++  + ++ +L Q+ ++ EE LA     LREQ Q  E
Sbjct: 2581 EARRRQHEAE-----------EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2629

Query: 325  EE 326
            E+
Sbjct: 2630 EQ 2631



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/132 (25%), Positives = 65/132 (49%), Gaps = 13/132 (9%)

Query: 209  TEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRIS 268
            T+   + +EAE+QR     Q    AEAER+ L+V +++R Q +  ++ Q+ + + +  I 
Sbjct: 2388 TQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAEEDAQR-FRKQAEEIG 2441

Query: 269  EHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAP 328
            E        + +T+L  Q        ++  RQ++    E L  A  EL  + ++ ++EA 
Sbjct: 2442 EK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2494

Query: 329  GLKCQVTELHDV 340
             L+ +  E+  V
Sbjct: 2495 LLQLKSEEMQTV 2506



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 77/339 (22%), Positives = 127/339 (37%), Gaps = 58/339 (17%)

Query: 28   ELRARRGSQDPRRRPAED--RAARAIQGAFRQLRARR--ELARRREERREYLE------- 76
            +LRA+  +Q P      D  R A+ +    +Q    R  E+ R RE   + LE       
Sbjct: 1161 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1220

Query: 77   QMETPQKEVEQLLTREGVGHDEAG-------EARRLQRRVALAECEDSYGNTPLSEAAAG 129
            Q +  Q+E+EQL  +     + A        +ARR Q ++      DS     + E    
Sbjct: 1221 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQ 1277

Query: 130  GQPLAIQLRAELGASPNSKGAFGPTPL-----YRAAFGGHLAAVEVLLKLGADPRVYAED 184
             Q L  ++    G        F    +     Y      + A +E +      P+V +  
Sbjct: 1278 EQALLEEIERH-GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1336

Query: 185  GSTPERVASLDT---VVSVLRSWDLSLTEAMLQNMEAE----QQRRAQEAQRHKEAEAER 237
             S  +    L T    ++ L S  +      L+ ME E    +Q+RA+E  R + AE E 
Sbjct: 1337 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEA 1394

Query: 238  MTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDR 297
               K +QL     Q   + ++   EL +R+ E                + ++  EA VD 
Sbjct: 1395 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE----------------EVVRREEAAVDA 1438

Query: 298  LRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTE 336
             +Q+    EE      L+   Q+ E E +A   + +  E
Sbjct: 1439 QQQKRSIQEE------LQQLRQSSEAEIQAKARQAEAAE 1471



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 68/322 (21%), Positives = 129/322 (40%), Gaps = 33/322 (10%)

Query: 29   LRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQL 88
            LRA     + +R+  E+  A          R +RE A   ++R+E   ++   + E+E L
Sbjct: 1745 LRAETEQGEQQRQLLEEELA----------RLQREAAAATQKRQELEAELAKVRAEMEVL 1794

Query: 89   LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSK 148
            L  +    +E+       ++   AE         L+E AA  + LA + + +   +   +
Sbjct: 1795 LASKARAEEESRSTSEKSKQRLEAEAGRF---RELAEEAARLRALAEEAKRQRQLA--EE 1849

Query: 149  GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV-YAEDGSTPERVASLDTVVSVLRSWDLS 207
             A              LAA+    +L  +  +   E  +  ER+  L    +  R     
Sbjct: 1850 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR---R 1906

Query: 208  LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKEL----------- 256
            L E   Q+ +A+ + R  + ++  ++E ER    V+   R+++Q  +E+           
Sbjct: 1907 LEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1965

Query: 257  -QQAYCELS-RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARL 314
              +A  EL   RI  + +   R  ++ +L     +   A+ +R R+EA++  +    A  
Sbjct: 1966 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2025

Query: 315  ELREQTQEGEEEAPGLKCQVTE 336
            E   Q +   EE   LK +V E
Sbjct: 2026 EAARQRKAALEEVERLKAKVEE 2047



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 3/91 (3%)

Query: 26   APELRARRGSQDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEV 85
            A +LR  +  Q  +      R   +++ A R+     E  RR++E    L+Q+E  +++ 
Sbjct: 2554 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLEQQRRQQ 2610

Query: 86   EQLLTREGVGHDEAGEARRLQRRVALAECED 116
            E+LL  E     E  +    Q R ALA  E+
Sbjct: 2611 EELLAEENQRLREQLQLLEEQHRAALAHSEE 2641



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)

Query: 193  SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 239
            SL   V ++RSW L    A  + ++ E+QR+A  + + H +A              +R+ 
Sbjct: 925  SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 980

Query: 240  LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 298
             +     RE   C    QQ    L +   E  +C+ RC+ + K + LQ        V RL
Sbjct: 981  AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 1034

Query: 299  RQEAQKAEEALAMARLELREQTQEGEEEAPG 329
            R    K E A   A+    +Q  + E E  G
Sbjct: 1035 RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1064


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 35/98 (35%), Positives = 50/98 (51%), Gaps = 2/98 (2%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GH   G  + L  R +  +     GNT L  A+  GQ   +++  + GA+ N++   G T
Sbjct: 54  GH--VGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFT 111

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA 192
           PLY AA   H+  V+ LL+ GA+     EDG TP  VA
Sbjct: 112 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 149



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 33/105 (31%), Positives = 49/105 (46%)

Query: 97  DEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPL 156
           D+   A  L +  A  +     G TPL  A   G    +    + GA+ N+K   G TPL
Sbjct: 685 DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 744

Query: 157 YRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 201
           ++AA  GH   + VLL+ GA P     +G+T   +A     +SV+
Sbjct: 745 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 789



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 32/92 (34%), Positives = 43/92 (46%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           A+ L +R A A+     G TPL  AA         L  E GASP++    G TPL+ AA 
Sbjct: 558 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 617

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
              +     LL  GA+  +  + G TP  +AS
Sbjct: 618 KNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 649



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 39/123 (31%), Positives = 58/123 (47%), Gaps = 2/123 (1%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A    +   ++L  + GAS  +    G TP++ AAF GHL  V +LL+ GA P
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436

Query: 179 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERM 238
            V    G T   +A+    V V+R   L    A++     E+Q     A R  + E  ++
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRC--LLRNGALVDARAREEQTPLHIASRLGKTEIVQL 494

Query: 239 TLK 241
            L+
Sbjct: 495 LLQ 497



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 30/92 (32%), Positives = 45/92 (48%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           A  L  R A  +     G TPL  A+  G    ++L  + G   ++K   G TPL+ AA 
Sbjct: 228 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 287

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            GH   VE+LL+ GA      ++G +P  +A+
Sbjct: 288 SGHDQVVELLLERGAPLLARTKNGLSPLHMAA 319



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 30/91 (32%), Positives = 44/91 (48%)

Query: 103 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 162
           R L R  AL +       TPL  A+  G+   +QL  +  A P++    G TPL+ +A  
Sbjct: 460 RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE 519

Query: 163 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
           G +    VLL+ GA   +  + G TP  VA+
Sbjct: 520 GQVDVASVLLEAGAAHSLATKKGFTPLHVAA 550



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 27/75 (36%), Positives = 39/75 (52%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA  G     +L  +  A+ +S G  G TPL+ AA   +     +LL+ GA P
Sbjct: 542 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 601

Query: 179 RVYAEDGSTPERVAS 193
              A++G TP  +A+
Sbjct: 602 HATAKNGYTPLHIAA 616



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 25/73 (34%), Positives = 37/73 (50%)

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 180
           T L  AA  G     +L  +  A+PN++   G TPL+ A     +  +E+L+K GA  + 
Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 405

Query: 181 YAEDGSTPERVAS 193
             E G TP  VA+
Sbjct: 406 ITESGLTPIHVAA 418



 Score = 37.0 bits (84), Expect = 0.040
 Identities = 27/82 (32%), Positives = 37/82 (45%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA   Q          GA  N     G TPL+ A+  GH   V +LL  GA+ 
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
            +  + G T   +A+ +  V+V
Sbjct: 668 HMSTKSGLTSLHLAAQEDKVNV 689



 Score = 36.2 bits (82), Expect = 0.068
 Identities = 25/84 (29%), Positives = 42/84 (50%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G   L  AA  G    +Q     G+S +S    G T L+ A+  G    V+VL+K GA+ 
Sbjct: 43  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 102

Query: 179 RVYAEDGSTPERVASLDTVVSVLR 202
              +++G TP  +A+ +  + V++
Sbjct: 103 NAQSQNGFTPLYMAAQENHIDVVK 126



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 37/129 (28%), Positives = 54/129 (41%), Gaps = 16/129 (12%)

Query: 65  ARRREERREYLEQMETPQKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLS 124
           AR REE+          + E+ QLL +  + H +A                   G TPL 
Sbjct: 471 ARAREEQTPLHIASRLGKTEIVQLLLQH-MAHPDAATTN---------------GYTPLH 514

Query: 125 EAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAED 184
            +A  GQ     +  E GA+ +     G TPL+ AA  G L   ++LL+  A      ++
Sbjct: 515 ISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 574

Query: 185 GSTPERVAS 193
           G TP  VA+
Sbjct: 575 GLTPLHVAA 583



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 21/55 (38%), Positives = 30/55 (54%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLK 173
           G TPL  AA  G    ++L  E GA   ++   G +PL+ AA G H+  V+ LL+
Sbjct: 278 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 332



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 24/82 (29%), Positives = 39/82 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G T L  AA  GQ   ++     GA  +++     TPL+ A+  G    V++LL+  A P
Sbjct: 443 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 502

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
                +G TP  +++ +  V V
Sbjct: 503 DAATTNGYTPLHISAREGQVDV 524



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 15/117 (12%)

Query: 105 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 164
           L ++ A    +   G TPL +AA  G    I +  + GA PN+  A G T L  A   G+
Sbjct: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785

Query: 165 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQ 221
           ++ V+ L       +V  E+ +T        T  ++     L++ E M + ++   +
Sbjct: 786 ISVVDTL-------KVVTEEVTT--------TTTTITEKHKLNVPETMTEVLDVSDE 827



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 29/86 (33%), Positives = 38/86 (44%), Gaps = 3/86 (3%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA  G      L    GA+ +     G TPL+ A+  G+   V++LL  G   
Sbjct: 212 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 271

Query: 179 RVYAEDGSTPERVASL---DTVVSVL 201
                DG TP   A+    D VV +L
Sbjct: 272 DAKTRDGLTPLHCAARSGHDQVVELL 297



 Score = 33.1 bits (74), Expect = 0.58
 Identities = 24/74 (32%), Positives = 35/74 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A+  G    + L  + GA+ +     G T L+ AA    +   ++L K GAD 
Sbjct: 641 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 700

Query: 179 RVYAEDGSTPERVA 192
             + + G TP  VA
Sbjct: 701 DAHTKLGYTPLIVA 714



 Score = 32.3 bits (72), Expect = 0.99
 Identities = 30/107 (28%), Positives = 44/107 (41%), Gaps = 2/107 (1%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GHD+  E   L  R A        G +PL  AA G     ++   +  A  +       T
Sbjct: 289 GHDQVVEL--LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLT 346

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 201
            L+ AA  GH    ++LL   A+P   A +G TP  +A     + V+
Sbjct: 347 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 393



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 22/70 (31%), Positives = 32/70 (45%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G T L  AA   +     +  + GA  ++    G TPL  A   G++  V  LLK GA+ 
Sbjct: 674 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 733

Query: 179 RVYAEDGSTP 188
               ++G TP
Sbjct: 734 NAKTKNGYTP 743


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 35/98 (35%), Positives = 50/98 (51%), Gaps = 2/98 (2%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GH   G  + L  R +  +     GNT L  A+  GQ   +++  + GA+ N++   G T
Sbjct: 75  GH--VGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFT 132

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA 192
           PLY AA   H+  V+ LL+ GA+     EDG TP  VA
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 33/105 (31%), Positives = 49/105 (46%)

Query: 97  DEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPL 156
           D+   A  L +  A  +     G TPL  A   G    +    + GA+ N+K   G TPL
Sbjct: 706 DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 765

Query: 157 YRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 201
           ++AA  GH   + VLL+ GA P     +G+T   +A     +SV+
Sbjct: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 32/92 (34%), Positives = 43/92 (46%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           A+ L +R A A+     G TPL  AA         L  E GASP++    G TPL+ AA 
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
              +     LL  GA+  +  + G TP  +AS
Sbjct: 639 KNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 670



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 39/123 (31%), Positives = 58/123 (47%), Gaps = 2/123 (1%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A    +   ++L  + GAS  +    G TP++ AAF GHL  V +LL+ GA P
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457

Query: 179 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERM 238
            V    G T   +A+    V V+R   L    A++     E+Q     A R  + E  ++
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRC--LLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515

Query: 239 TLK 241
            L+
Sbjct: 516 LLQ 518



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 30/92 (32%), Positives = 45/92 (48%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           A  L  R A  +     G TPL  A+  G    ++L  + G   ++K   G TPL+ AA 
Sbjct: 249 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 308

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            GH   VE+LL+ GA      ++G +P  +A+
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAA 340



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 30/91 (32%), Positives = 44/91 (48%)

Query: 103 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 162
           R L R  AL +       TPL  A+  G+   +QL  +  A P++    G TPL+ +A  
Sbjct: 481 RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE 540

Query: 163 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
           G +    VLL+ GA   +  + G TP  VA+
Sbjct: 541 GQVDVASVLLEAGAAHSLATKKGFTPLHVAA 571



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 27/75 (36%), Positives = 39/75 (52%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA  G     +L  +  A+ +S G  G TPL+ AA   +     +LL+ GA P
Sbjct: 563 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622

Query: 179 RVYAEDGSTPERVAS 193
              A++G TP  +A+
Sbjct: 623 HATAKNGYTPLHIAA 637



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 25/73 (34%), Positives = 37/73 (50%)

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 180
           T L  AA  G     +L  +  A+PN++   G TPL+ A     +  +E+L+K GA  + 
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426

Query: 181 YAEDGSTPERVAS 193
             E G TP  VA+
Sbjct: 427 ITESGLTPIHVAA 439



 Score = 37.0 bits (84), Expect = 0.040
 Identities = 27/82 (32%), Positives = 37/82 (45%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA   Q          GA  N     G TPL+ A+  GH   V +LL  GA+ 
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
            +  + G T   +A+ +  V+V
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNV 710



 Score = 36.2 bits (82), Expect = 0.068
 Identities = 25/84 (29%), Positives = 42/84 (50%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G   L  AA  G    +Q     G+S +S    G T L+ A+  G    V+VL+K GA+ 
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123

Query: 179 RVYAEDGSTPERVASLDTVVSVLR 202
              +++G TP  +A+ +  + V++
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVK 147



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 37/129 (28%), Positives = 54/129 (41%), Gaps = 16/129 (12%)

Query: 65  ARRREERREYLEQMETPQKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLS 124
           AR REE+          + E+ QLL +  + H +A                   G TPL 
Sbjct: 492 ARAREEQTPLHIASRLGKTEIVQLLLQH-MAHPDAATTN---------------GYTPLH 535

Query: 125 EAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAED 184
            +A  GQ     +  E GA+ +     G TPL+ AA  G L   ++LL+  A      ++
Sbjct: 536 ISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 595

Query: 185 GSTPERVAS 193
           G TP  VA+
Sbjct: 596 GLTPLHVAA 604



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 21/55 (38%), Positives = 30/55 (54%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLK 173
           G TPL  AA  G    ++L  E GA   ++   G +PL+ AA G H+  V+ LL+
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 353



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 24/82 (29%), Positives = 39/82 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G T L  AA  GQ   ++     GA  +++     TPL+ A+  G    V++LL+  A P
Sbjct: 464 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 523

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
                +G TP  +++ +  V V
Sbjct: 524 DAATTNGYTPLHISAREGQVDV 545



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 15/117 (12%)

Query: 105 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 164
           L ++ A    +   G TPL +AA  G    I +  + GA PN+  A G T L  A   G+
Sbjct: 747 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806

Query: 165 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQ 221
           ++ V+ L       +V  E+ +T        T  ++     L++ E M + ++   +
Sbjct: 807 ISVVDTL-------KVVTEEVTT--------TTTTITEKHKLNVPETMTEVLDVSDE 848



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 29/86 (33%), Positives = 38/86 (44%), Gaps = 3/86 (3%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA  G      L    GA+ +     G TPL+ A+  G+   V++LL  G   
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292

Query: 179 RVYAEDGSTPERVASL---DTVVSVL 201
                DG TP   A+    D VV +L
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELL 318



 Score = 33.1 bits (74), Expect = 0.58
 Identities = 24/74 (32%), Positives = 35/74 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A+  G    + L  + GA+ +     G T L+ AA    +   ++L K GAD 
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721

Query: 179 RVYAEDGSTPERVA 192
             + + G TP  VA
Sbjct: 722 DAHTKLGYTPLIVA 735



 Score = 32.3 bits (72), Expect = 0.99
 Identities = 30/107 (28%), Positives = 44/107 (41%), Gaps = 2/107 (1%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GHD+  E   L  R A        G +PL  AA G     ++   +  A  +       T
Sbjct: 310 GHDQVVEL--LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLT 367

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 201
            L+ AA  GH    ++LL   A+P   A +G TP  +A     + V+
Sbjct: 368 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 414



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 22/70 (31%), Positives = 32/70 (45%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G T L  AA   +     +  + GA  ++    G TPL  A   G++  V  LLK GA+ 
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754

Query: 179 RVYAEDGSTP 188
               ++G TP
Sbjct: 755 NAKTKNGYTP 764


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 35/98 (35%), Positives = 50/98 (51%), Gaps = 2/98 (2%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GH   G  + L  R +  +     GNT L  A+  GQ   +++  + GA+ N++   G T
Sbjct: 75  GH--VGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFT 132

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA 192
           PLY AA   H+  V+ LL+ GA+     EDG TP  VA
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 33/105 (31%), Positives = 49/105 (46%)

Query: 97  DEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPL 156
           D+   A  L +  A  +     G TPL  A   G    +    + GA+ N+K   G TPL
Sbjct: 706 DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 765

Query: 157 YRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 201
           ++AA  GH   + VLL+ GA P     +G+T   +A     +SV+
Sbjct: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 32/92 (34%), Positives = 43/92 (46%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           A+ L +R A A+     G TPL  AA         L  E GASP++    G TPL+ AA 
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
              +     LL  GA+  +  + G TP  +AS
Sbjct: 639 KNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 670



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 39/123 (31%), Positives = 58/123 (47%), Gaps = 2/123 (1%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A    +   ++L  + GAS  +    G TP++ AAF GHL  V +LL+ GA P
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457

Query: 179 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERM 238
            V    G T   +A+    V V+R   L    A++     E+Q     A R  + E  ++
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRC--LLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515

Query: 239 TLK 241
            L+
Sbjct: 516 LLQ 518



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 30/92 (32%), Positives = 45/92 (48%)

Query: 102 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 161
           A  L  R A  +     G TPL  A+  G    ++L  + G   ++K   G TPL+ AA 
Sbjct: 249 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 308

Query: 162 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
            GH   VE+LL+ GA      ++G +P  +A+
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAA 340



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 30/91 (32%), Positives = 44/91 (48%)

Query: 103 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 162
           R L R  AL +       TPL  A+  G+   +QL  +  A P++    G TPL+ +A  
Sbjct: 481 RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE 540

Query: 163 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS 193
           G +    VLL+ GA   +  + G TP  VA+
Sbjct: 541 GQVDVASVLLEAGAAHSLATKKGFTPLHVAA 571



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 27/75 (36%), Positives = 39/75 (52%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA  G     +L  +  A+ +S G  G TPL+ AA   +     +LL+ GA P
Sbjct: 563 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622

Query: 179 RVYAEDGSTPERVAS 193
              A++G TP  +A+
Sbjct: 623 HATAKNGYTPLHIAA 637



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 25/73 (34%), Positives = 37/73 (50%)

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 180
           T L  AA  G     +L  +  A+PN++   G TPL+ A     +  +E+L+K GA  + 
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426

Query: 181 YAEDGSTPERVAS 193
             E G TP  VA+
Sbjct: 427 ITESGLTPIHVAA 439



 Score = 37.0 bits (84), Expect = 0.040
 Identities = 27/82 (32%), Positives = 37/82 (45%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA   Q          GA  N     G TPL+ A+  GH   V +LL  GA+ 
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
            +  + G T   +A+ +  V+V
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNV 710



 Score = 36.2 bits (82), Expect = 0.068
 Identities = 25/84 (29%), Positives = 42/84 (50%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G   L  AA  G    +Q     G+S +S    G T L+ A+  G    V+VL+K GA+ 
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123

Query: 179 RVYAEDGSTPERVASLDTVVSVLR 202
              +++G TP  +A+ +  + V++
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVK 147



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 37/129 (28%), Positives = 54/129 (41%), Gaps = 16/129 (12%)

Query: 65  ARRREERREYLEQMETPQKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLS 124
           AR REE+          + E+ QLL +  + H +A                   G TPL 
Sbjct: 492 ARAREEQTPLHIASRLGKTEIVQLLLQH-MAHPDAATTN---------------GYTPLH 535

Query: 125 EAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAED 184
            +A  GQ     +  E GA+ +     G TPL+ AA  G L   ++LL+  A      ++
Sbjct: 536 ISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 595

Query: 185 GSTPERVAS 193
           G TP  VA+
Sbjct: 596 GLTPLHVAA 604



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 21/55 (38%), Positives = 30/55 (54%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLK 173
           G TPL  AA  G    ++L  E GA   ++   G +PL+ AA G H+  V+ LL+
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 353



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 24/82 (29%), Positives = 39/82 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G T L  AA  GQ   ++     GA  +++     TPL+ A+  G    V++LL+  A P
Sbjct: 464 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 523

Query: 179 RVYAEDGSTPERVASLDTVVSV 200
                +G TP  +++ +  V V
Sbjct: 524 DAATTNGYTPLHISAREGQVDV 545



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 15/117 (12%)

Query: 105 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 164
           L ++ A    +   G TPL +AA  G    I +  + GA PN+  A G T L  A   G+
Sbjct: 747 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806

Query: 165 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQ 221
           ++ V+ L       +V  E+ +T        T  ++     L++ E M + ++   +
Sbjct: 807 ISVVDTL-------KVVTEEVTT--------TTTTITEKHKLNVPETMTEVLDVSDE 848



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 29/86 (33%), Positives = 38/86 (44%), Gaps = 3/86 (3%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  AA  G      L    GA+ +     G TPL+ A+  G+   V++LL  G   
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292

Query: 179 RVYAEDGSTPERVASL---DTVVSVL 201
                DG TP   A+    D VV +L
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELL 318



 Score = 33.1 bits (74), Expect = 0.58
 Identities = 24/74 (32%), Positives = 35/74 (47%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL  A+  G    + L  + GA+ +     G T L+ AA    +   ++L K GAD 
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721

Query: 179 RVYAEDGSTPERVA 192
             + + G TP  VA
Sbjct: 722 DAHTKLGYTPLIVA 735



 Score = 32.3 bits (72), Expect = 0.99
 Identities = 30/107 (28%), Positives = 44/107 (41%), Gaps = 2/107 (1%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GHD+  E   L  R A        G +PL  AA G     ++   +  A  +       T
Sbjct: 310 GHDQVVEL--LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLT 367

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 201
            L+ AA  GH    ++LL   A+P   A +G TP  +A     + V+
Sbjct: 368 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 414



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 22/70 (31%), Positives = 32/70 (45%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G T L  AA   +     +  + GA  ++    G TPL  A   G++  V  LLK GA+ 
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754

Query: 179 RVYAEDGSTP 188
               ++G TP
Sbjct: 755 NAKTKNGYTP 764


>gi|67906195 ankyrin repeat and sterile alpha motif domain
           containing 6 [Homo sapiens]
          Length = 871

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 42/130 (32%), Positives = 57/130 (43%), Gaps = 5/130 (3%)

Query: 69  EERREYLEQ--METPQKEVEQLLTREGVGHDEAGEARRLQRRVAL---AECEDSYGNTPL 123
           E  R  LE    E  ++  E     E  G + AG        V      +C D  GNT L
Sbjct: 23  ETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVDCSDEAGNTAL 82

Query: 124 SEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAE 183
             AAAGG    ++     GAS NS+  +G + L +AA  GH++   +LL  GAD      
Sbjct: 83  QFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNR 142

Query: 184 DGSTPERVAS 193
            G++   VAS
Sbjct: 143 LGASVLTVAS 152



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 10/123 (8%)

Query: 73  EYLEQMETPQKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSY-------GNTPLSE 125
           +YL+ + T + + ++   R  + H  A +    Q    +A+ + S+       G TPL  
Sbjct: 275 DYLDPLTTVRPKTDEEKRRPDIFH--ALKMGNFQLVKEIADEDPSHVNLVNGDGATPLML 332

Query: 126 AAAGGQPLAIQLRAELGASPNSK-GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAED 184
           AA  GQ   +QL  E  A  + +    G T L +A + G+   V+ LL  GAD  + A++
Sbjct: 333 AAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKN 392

Query: 185 GST 187
           G T
Sbjct: 393 GYT 395



 Score = 33.5 bits (75), Expect = 0.44
 Identities = 21/59 (35%), Positives = 28/59 (47%), Gaps = 1/59 (1%)

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPNSKG-AFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           T L  A   G    ++L  E GA PN      G +PL  AA  G L   + L++ GA+P
Sbjct: 193 TALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANP 251


>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
           sapiens]
          Length = 587

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 32/84 (38%), Positives = 44/84 (52%)

Query: 110 ALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVE 169
           A  E +++YG TPL  AA  GQ  A++  A+ GA  N++ +   + LY A    H   VE
Sbjct: 214 AKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVE 273

Query: 170 VLLKLGADPRVYAEDGSTPERVAS 193
            LL  GAD     +DG  P  +AS
Sbjct: 274 FLLSQGADANKTNKDGLLPLHIAS 297



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 26/69 (37%), Positives = 35/69 (50%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G T L E+ +      +Q+    GA   SK A+G TPL+ AA  G L A+  L K GAD 
Sbjct: 190 GWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADI 249

Query: 179 RVYAEDGST 187
              A D ++
Sbjct: 250 NTQASDNAS 258



 Score = 29.6 bits (65), Expect = 6.4
 Identities = 35/152 (23%), Positives = 63/152 (41%), Gaps = 19/152 (12%)

Query: 122 PLSEAAAGGQPLAIQLRAELG---ASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           PL +A   G   A++   + G   A PN +G     PL+ AA+ G +  ++VL +     
Sbjct: 60  PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWL---PLHEAAYYGQVGCLKVLQR----- 111

Query: 179 RVYAEDGSTPERVASLDTVV--SVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAE-- 234
              A  G+  +R    +T V  +  R     L   +    E +   +++E   +K  E  
Sbjct: 112 ---AYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERK 168

Query: 235 -AERMTLKVQQLTREQQQCHKELQQAYCELSR 265
            AE + + VQ       +C++     +  +SR
Sbjct: 169 NAEAVKILVQHNADTNHRCNRGWTALHESVSR 200



 Score = 29.3 bits (64), Expect = 8.4
 Identities = 22/71 (30%), Positives = 34/71 (47%), Gaps = 1/71 (1%)

Query: 119 GNTPLSEAAAGGQPLAIQ-LRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGAD 177
           G  PL EAA  GQ   ++ L+     + + +     T +Y A   GHL  +  LL+ GA+
Sbjct: 90  GWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAE 149

Query: 178 PRVYAEDGSTP 188
           P +  +   TP
Sbjct: 150 PDISNKSRETP 160


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 38/94 (40%), Positives = 46/94 (48%), Gaps = 3/94 (3%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGP- 153
           GH +  +   L +  A  E E   G TPL +AA  G    +Q     GA+ N   A    
Sbjct: 608 GHTDVADV--LLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDH 665

Query: 154 TPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGST 187
           T L  A  GGHLA VE+LL  GADP    +DGST
Sbjct: 666 TVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 28/68 (41%), Positives = 36/68 (52%)

Query: 116  DSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLG 175
            +S  +T L+ A AGG    +Q   E GAS   +   G TPL  AA  GH+  VE+LL  G
Sbjct: 1080 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139

Query: 176  ADPRVYAE 183
            AD    +E
Sbjct: 1140 ADIEAQSE 1147



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 27/59 (45%), Positives = 36/59 (61%), Gaps = 2/59 (3%)

Query: 121  TPLSEAAAGGQPLAIQLRAELGASPNSK--GAFGPTPLYRAAFGGHLAAVEVLLKLGAD 177
            TPLS AA+GG    I++    GA  NS+     G +PL  AA  GH AAV++LL +G+D
Sbjct: 1185 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSD 1243



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 30/82 (36%), Positives = 41/82 (50%)

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 180
           TPL  AA GG    ++L     A  N++ + G T L  A  GG++  V+VLL+ GA    
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 181 YAEDGSTPERVASLDTVVSVLR 202
           + E+G TP   A     V V R
Sbjct: 363 HNENGHTPLMEAGSAGHVEVAR 384



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 37/111 (33%), Positives = 49/111 (44%), Gaps = 4/111 (3%)

Query: 110 ALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNS-KGAFGPTPLYRAAFGGHLAAV 168
           A  E  +  G+TPL EA + G     +L  E GA  N+    F  + L  A + GHL  V
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMV 417

Query: 169 EVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAE 219
             LL+ GAD     ++  T    A +D  V V R   L L      NM A+
Sbjct: 418 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR---LLLDSGAQVNMPAD 465



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 2/101 (1%)

Query: 84  EVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGA 143
           ++  L+     GH +    + L    A    + S GNT L+ A AGG    +++  E GA
Sbjct: 301 DITPLMAAANGGHVKI--VKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGA 358

Query: 144 SPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAED 184
           S       G TPL  A   GH+    +LL+ GA    ++ +
Sbjct: 359 SIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE 399



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 25/78 (32%), Positives = 45/78 (57%), Gaps = 2/78 (2%)

Query: 120  NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGAD-- 177
            +TPLS A +GG+   ++L    GA+   +     TPL  AA GG++  +++LL  GA+  
Sbjct: 1151 DTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1210

Query: 178  PRVYAEDGSTPERVASLD 195
             R  ++ G +P  +A+++
Sbjct: 1211 SRTGSKLGISPLMLAAMN 1228



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 26/69 (37%), Positives = 35/69 (50%)

Query: 120 NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 179
           +TPL EAA  G    ++     GA+ ++  A G T L  A   GH    +VLL+ GAD  
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624

Query: 180 VYAEDGSTP 188
             +E G TP
Sbjct: 625 HESEGGRTP 633



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 51/191 (26%), Positives = 87/191 (45%), Gaps = 19/191 (9%)

Query: 108  RVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAA 167
            R A  +  +  GNTPL  AA GG    +QL  + GA  ++      TPL  A   GH+  
Sbjct: 1342 RGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKV 1401

Query: 168  VEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA 227
            V  L+K   +   +  D      +A++ T   +L+   L + E+++Q     + R+A EA
Sbjct: 1402 VRYLVK---EVNQFPSDSECMRYIATI-TDKEMLKKCHLCM-ESIVQ----AKDRQAAEA 1452

Query: 228  QRHKEAEAERMTL-KVQQLTRE-----QQQCHKELQQAYCELSRRISEHDQCEWRCMDKT 281
             ++     E + L K+++ +R      +++  KE ++   E  RR  E    E    +K 
Sbjct: 1453 NKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLE----EIEAKNKE 1508

Query: 282  KLTLQAIKDTE 292
               LQA ++ E
Sbjct: 1509 NFELQAAQEKE 1519



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 49/207 (23%), Positives = 93/207 (44%), Gaps = 33/207 (15%)

Query: 120  NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 179
            +T L+ AA  G     +L    GA  + +   G TPL+ AA GGHL  V++L++ GAD  
Sbjct: 1321 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD-- 1378

Query: 180  VYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMT 239
            V A D         +  +++  R   + +   +++  E  Q     E  R+     ++  
Sbjct: 1379 VDAADN------RKITPLMAAFRKGHVKVVRYLVK--EVNQFPSDSECMRYIATITDKEM 1430

Query: 240  LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLR 299
            LK         +CH  ++       R+ +E ++          + L+     E  +++LR
Sbjct: 1431 LK---------KCHLCMESIVQAKDRQAAEANK-------NASILLE-----ELDLEKLR 1469

Query: 300  QEAQKAEEALAMARLELREQTQEGEEE 326
            +E+++   ALA  R + +E+ ++ +EE
Sbjct: 1470 EESRRL--ALAAKREKRKEKRRKKKEE 1494



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 34/102 (33%), Positives = 44/102 (43%), Gaps = 2/102 (1%)

Query: 77  QMETPQKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQ 136
           Q+  P    E  LT    G      A  ++R  +L E  D  G TPL EAA  G    + 
Sbjct: 459 QVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDE-GYTPLMEAAREGHEEMVA 517

Query: 137 LRAELGASPNSK-GAFGPTPLYRAAFGGHLAAVEVLLKLGAD 177
           L    GA+ N++      T L  A  GG L   + L+K GAD
Sbjct: 518 LLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD 559



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 33/109 (30%), Positives = 49/109 (44%), Gaps = 3/109 (2%)

Query: 95   GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGA-FGP 153
            GH+E    + L  R A  E  D  G TPL  AA  G    +++  + GA   ++      
Sbjct: 1094 GHEEL--VQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD 1151

Query: 154  TPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR 202
            TPL  A  GG    VE+LL  GA+         TP  +A+    V++++
Sbjct: 1152 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1200



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 59/276 (21%), Positives = 109/276 (39%), Gaps = 52/276 (18%)

Query: 120 NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLL------- 172
           +T LS A AGG    ++L    GA P  +   G T L  AA GGH + V  LL       
Sbjct: 665 HTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLL 724

Query: 173 ---------------KLGADPRVYA----------EDGSTPERVASLDTVVSVLRSWDLS 207
                           L   PRV            E    P  VA+   + +   S   S
Sbjct: 725 SAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQKS 784

Query: 208 LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQ---AYCE-- 262
            +     + + +     Q  +   E EA+    +++Q  +E  + + +LQ    A+ +  
Sbjct: 785 SSHLPANSQDVQGYITNQSPESIVE-EAQGKLTELEQRIKEAIEKNAQLQSLELAHADQL 843

Query: 263 LSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVD-RLRQEAQKAEEALAMARLELREQTQ 321
              +I E ++     + K +  L+ ++  E ++  + +Q+ +K    +   R++L++Q Q
Sbjct: 844 TKEKIEELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQQ 903

Query: 322 E-------------GEEEAPGLKCQVTELHDVLMKD 344
           +             GE+ + G   ++ ++  VL+KD
Sbjct: 904 QSCQHLGLLTPVGVGEQLSEGDYARLQQVDPVLLKD 939



 Score = 36.6 bits (83), Expect = 0.052
 Identities = 27/69 (39%), Positives = 33/69 (47%), Gaps = 1/69 (1%)

Query: 116 DSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLG 175
           DS+  +PL+ AA GG      L  E GAS       G TPL  AA  GH   V +LL  G
Sbjct: 465 DSF-ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQG 523

Query: 176 ADPRVYAED 184
           A+     E+
Sbjct: 524 ANINAQTEE 532



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 22/69 (31%), Positives = 32/69 (46%)

Query: 120 NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 179
           +T L EA   G     +L  + GA  N       +PL  AA GGH+    +L++ GA   
Sbjct: 435 HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLE 494

Query: 180 VYAEDGSTP 188
              ++G TP
Sbjct: 495 EVNDEGYTP 503



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 7/81 (8%)

Query: 120  NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 179
            NT L+ A   G+   + L  +  A+   +   G TPL  AA GG+     VLL  GAD  
Sbjct: 1253 NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV- 1311

Query: 180  VYAEDGSTPERVASLDTVVSV 200
                  + P   +S DT +++
Sbjct: 1312 ------NAPPVPSSRDTALTI 1326


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
           sapiens]
          Length = 2352

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 38/94 (40%), Positives = 46/94 (48%), Gaps = 3/94 (3%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGP- 153
           GH +  +   L +  A  E E   G TPL +AA  G    +Q     GA+ N   A    
Sbjct: 608 GHTDVADV--LLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDH 665

Query: 154 TPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGST 187
           T L  A  GGHLA VE+LL  GADP    +DGST
Sbjct: 666 TVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 28/68 (41%), Positives = 36/68 (52%)

Query: 116 DSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLG 175
           +S  +T L+ A AGG    +Q   E GAS   +   G TPL  AA  GH+  VE+LL  G
Sbjct: 829 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 888

Query: 176 ADPRVYAE 183
           AD    +E
Sbjct: 889 ADIEAQSE 896



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 27/59 (45%), Positives = 36/59 (61%), Gaps = 2/59 (3%)

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPNSK--GAFGPTPLYRAAFGGHLAAVEVLLKLGAD 177
           TPLS AA+GG    I++    GA  NS+     G +PL  AA  GH AAV++LL +G+D
Sbjct: 934 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSD 992



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 30/82 (36%), Positives = 41/82 (50%)

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 180
           TPL  AA GG    ++L     A  N++ + G T L  A  GG++  V+VLL+ GA    
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 181 YAEDGSTPERVASLDTVVSVLR 202
           + E+G TP   A     V V R
Sbjct: 363 HNENGHTPLMEAGSAGHVEVAR 384



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 37/111 (33%), Positives = 49/111 (44%), Gaps = 4/111 (3%)

Query: 110 ALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNS-KGAFGPTPLYRAAFGGHLAAV 168
           A  E  +  G+TPL EA + G     +L  E GA  N+    F  + L  A + GHL  V
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMV 417

Query: 169 EVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAE 219
             LL+ GAD     ++  T    A +D  V V R   L L      NM A+
Sbjct: 418 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR---LLLDSGAQVNMPAD 465



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 2/101 (1%)

Query: 84  EVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGA 143
           ++  L+     GH +    + L    A    + S GNT L+ A AGG    +++  E GA
Sbjct: 301 DITPLMAAANGGHVKI--VKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGA 358

Query: 144 SPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAED 184
           S       G TPL  A   GH+    +LL+ GA    ++ +
Sbjct: 359 SIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE 399



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 25/78 (32%), Positives = 45/78 (57%), Gaps = 2/78 (2%)

Query: 120 NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGAD-- 177
           +TPLS A +GG+   ++L    GA+   +     TPL  AA GG++  +++LL  GA+  
Sbjct: 900 DTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 959

Query: 178 PRVYAEDGSTPERVASLD 195
            R  ++ G +P  +A+++
Sbjct: 960 SRTGSKLGISPLMLAAMN 977



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 26/69 (37%), Positives = 35/69 (50%)

Query: 120 NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 179
           +TPL EAA  G    ++     GA+ ++  A G T L  A   GH    +VLL+ GAD  
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624

Query: 180 VYAEDGSTP 188
             +E G TP
Sbjct: 625 HESEGGRTP 633



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 51/191 (26%), Positives = 87/191 (45%), Gaps = 19/191 (9%)

Query: 108  RVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAA 167
            R A  +  +  GNTPL  AA GG    +QL  + GA  ++      TPL  A   GH+  
Sbjct: 1091 RGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKV 1150

Query: 168  VEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA 227
            V  L+K   +   +  D      +A++ T   +L+   L + E+++Q     + R+A EA
Sbjct: 1151 VRYLVK---EVNQFPSDSECMRYIATI-TDKEMLKKCHLCM-ESIVQ----AKDRQAAEA 1201

Query: 228  QRHKEAEAERMTL-KVQQLTRE-----QQQCHKELQQAYCELSRRISEHDQCEWRCMDKT 281
             ++     E + L K+++ +R      +++  KE ++   E  RR  E    E    +K 
Sbjct: 1202 NKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLE----EIEAKNKE 1257

Query: 282  KLTLQAIKDTE 292
               LQA ++ E
Sbjct: 1258 NFELQAAQEKE 1268



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 49/207 (23%), Positives = 93/207 (44%), Gaps = 33/207 (15%)

Query: 120  NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 179
            +T L+ AA  G     +L    GA  + +   G TPL+ AA GGHL  V++L++ GAD  
Sbjct: 1070 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD-- 1127

Query: 180  VYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMT 239
            V A D         +  +++  R   + +   +++  E  Q     E  R+     ++  
Sbjct: 1128 VDAADN------RKITPLMAAFRKGHVKVVRYLVK--EVNQFPSDSECMRYIATITDKEM 1179

Query: 240  LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLR 299
            LK         +CH  ++       R+ +E ++          + L+     E  +++LR
Sbjct: 1180 LK---------KCHLCMESIVQAKDRQAAEANK-------NASILLE-----ELDLEKLR 1218

Query: 300  QEAQKAEEALAMARLELREQTQEGEEE 326
            +E+++   ALA  R + +E+ ++ +EE
Sbjct: 1219 EESRRL--ALAAKREKRKEKRRKKKEE 1243



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 34/102 (33%), Positives = 44/102 (43%), Gaps = 2/102 (1%)

Query: 77  QMETPQKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQ 136
           Q+  P    E  LT    G      A  ++R  +L E  D  G TPL EAA  G    + 
Sbjct: 459 QVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDE-GYTPLMEAAREGHEEMVA 517

Query: 137 LRAELGASPNSK-GAFGPTPLYRAAFGGHLAAVEVLLKLGAD 177
           L    GA+ N++      T L  A  GG L   + L+K GAD
Sbjct: 518 LLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD 559



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 33/109 (30%), Positives = 49/109 (44%), Gaps = 3/109 (2%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGA-FGP 153
           GH+E    + L  R A  E  D  G TPL  AA  G    +++  + GA   ++      
Sbjct: 843 GHEEL--VQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD 900

Query: 154 TPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR 202
           TPL  A  GG    VE+LL  GA+         TP  +A+    V++++
Sbjct: 901 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949



 Score = 36.6 bits (83), Expect = 0.052
 Identities = 27/69 (39%), Positives = 33/69 (47%), Gaps = 1/69 (1%)

Query: 116 DSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLG 175
           DS+  +PL+ AA GG      L  E GAS       G TPL  AA  GH   V +LL  G
Sbjct: 465 DSF-ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQG 523

Query: 176 ADPRVYAED 184
           A+     E+
Sbjct: 524 ANINAQTEE 532



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 22/69 (31%), Positives = 32/69 (46%)

Query: 120 NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 179
           +T L EA   G     +L  + GA  N       +PL  AA GGH+    +L++ GA   
Sbjct: 435 HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLE 494

Query: 180 VYAEDGSTP 188
              ++G TP
Sbjct: 495 EVNDEGYTP 503



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 22/53 (41%), Positives = 27/53 (50%)

Query: 120 NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLL 172
           +T LS A AGG    ++L    GA P  +   G T L  AA GGH + V  LL
Sbjct: 665 HTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 7/81 (8%)

Query: 120  NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 179
            NT L+ A   G+   + L  +  A+   +   G TPL  AA GG+     VLL  GAD  
Sbjct: 1002 NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV- 1060

Query: 180  VYAEDGSTPERVASLDTVVSV 200
                  + P   +S DT +++
Sbjct: 1061 ------NAPPVPSSRDTALTI 1075


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 31/80 (38%), Positives = 45/80 (56%), Gaps = 1/80 (1%)

Query: 116 DSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLA-AVEVLLKL 174
           ++YGNTPL  A   GQ + +    + GA  N K   G TPL+ AA   H A  +E+L+  
Sbjct: 236 NAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGN 295

Query: 175 GADPRVYAEDGSTPERVASL 194
           GAD  + ++DG TP  + +L
Sbjct: 296 GADVNMKSKDGKTPLHMTAL 315



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 33/103 (32%), Positives = 45/103 (43%), Gaps = 2/103 (1%)

Query: 94  VGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGP 153
           +GH E    + L    A   C+D    TPL  AA+ G    ++   +LG   N   A+G 
Sbjct: 183 MGHIEV--VKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGN 240

Query: 154 TPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDT 196
           TPL+ A + G    V  L+  GA      E G TP   A+  T
Sbjct: 241 TPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAAST 283



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 28/82 (34%), Positives = 36/82 (43%)

Query: 96  HDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTP 155
           H     ++ + +  A+ +CED  GNTPL  AA  G  L I      GA    +G  G  P
Sbjct: 316 HGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFP 375

Query: 156 LYRAAFGGHLAAVEVLLKLGAD 177
           L+ AA  G       LL  G D
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFD 397



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 33/107 (30%), Positives = 50/107 (46%)

Query: 92  EGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAF 151
           + + + +  E R L  +      +D+   TPL  AA  G    I+L    GA  N+K + 
Sbjct: 14  QAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSK 73

Query: 152 GPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVV 198
             TPL+RA       AV+VLLK  AD     ++  TP  +A+ +  V
Sbjct: 74  WLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAV 120



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 28/78 (35%), Positives = 36/78 (46%)

Query: 116 DSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLG 175
           D +G T L  AAAGG    + L    GA  N K  FG +PL+ AA   +   +  L+  G
Sbjct: 402 DDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSG 461

Query: 176 ADPRVYAEDGSTPERVAS 193
           A      E G TP   A+
Sbjct: 462 ASVNDLDERGCTPLHYAA 479



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 26/89 (29%), Positives = 42/89 (47%)

Query: 113 ECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLL 172
           + +D  G TPL  +   G    +      GA+ ++K  +G T L+R A  GH   V+ LL
Sbjct: 647 DIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALL 706

Query: 173 KLGADPRVYAEDGSTPERVASLDTVVSVL 201
           + GA   +    G TP  +++    + VL
Sbjct: 707 QHGAKCLLRDSRGRTPIHLSAACGHIGVL 735



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 1/85 (1%)

Query: 110 ALAECEDSYGNTPLSEAAAGGQ-PLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAV 168
           A+   ++  G TPL  AAA     L ++L    GA  N K   G TPL+  A  G  +  
Sbjct: 263 AIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRS 322

Query: 169 EVLLKLGADPRVYAEDGSTPERVAS 193
           + +++ GA      ++G+TP  +A+
Sbjct: 323 QTIIQSGAVIDCEDKNGNTPLHIAA 347



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 6/83 (7%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQ----PLAIQLRAELGASPNSKGA 150
           GH+E  +A  L +  A     DS G TP+  +AA G        +Q  A + A+P +   
Sbjct: 697 GHEECVDA--LLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADN 754

Query: 151 FGPTPLYRAAFGGHLAAVEVLLK 173
            G T L+ A + GH   VE+LL+
Sbjct: 755 HGYTALHWACYNGHETCVELLLE 777



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 24/87 (27%), Positives = 42/87 (48%)

Query: 116 DSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLG 175
           D  G T L  AA  G    ++L    GA+ N+        ++ AA+ GH+  V++L+  G
Sbjct: 137 DRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHG 196

Query: 176 ADPRVYAEDGSTPERVASLDTVVSVLR 202
           A+     +   TP   A+   ++SV++
Sbjct: 197 AEVTCKDKKSYTPLHAAASSGMISVVK 223



 Score = 37.0 bits (84), Expect = 0.040
 Identities = 26/77 (33%), Positives = 34/77 (44%), Gaps = 1/77 (1%)

Query: 110 ALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVE 169
           ++    DS G TPL  AA       +QL     A  NS  + G TPL  AA  G    VE
Sbjct: 814 SIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVE 873

Query: 170 VLLKLGADPRVYAEDGS 186
           +L+   A   +  +D S
Sbjct: 874 MLVS-SASAELTLQDNS 889



 Score = 36.2 bits (82), Expect = 0.068
 Identities = 35/110 (31%), Positives = 45/110 (40%), Gaps = 5/110 (4%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           GH E    + L  R A     D      +  AA  G    ++L    GA    K     T
Sbjct: 151 GHGEM--VKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYT 208

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA---SLDTVVSVL 201
           PL+ AA  G ++ V+ LL LG D       G+TP  VA     D VV+ L
Sbjct: 209 PLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNEL 258



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 21/66 (31%), Positives = 36/66 (54%)

Query: 111 LAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEV 170
           L++ ++    +PL  AA  G   A+++  +     + + + G TPL  AAF GH+  V+V
Sbjct: 542 LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 601

Query: 171 LLKLGA 176
           L+  GA
Sbjct: 602 LINQGA 607



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 25/76 (32%), Positives = 34/76 (44%)

Query: 119 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 178
           G TPL   A  G+    Q   + GA  + +   G TPL+ AA  GH   +  L+  GAD 
Sbjct: 306 GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADT 365

Query: 179 RVYAEDGSTPERVASL 194
                 G  P  +A+L
Sbjct: 366 AKRGIHGMFPLHLAAL 381



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 24/73 (32%), Positives = 32/73 (43%)

Query: 105 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 164
           L +  A     D    TPL  AAA       +    L ++ N     G T L+ AAF GH
Sbjct: 93  LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGH 152

Query: 165 LAAVEVLLKLGAD 177
              V++LL  GA+
Sbjct: 153 GEMVKLLLSRGAN 165



 Score = 32.7 bits (73), Expect = 0.76
 Identities = 19/72 (26%), Positives = 33/72 (45%)

Query: 105 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 164
           L  + A  + +D +G T L   A  G    +    + GA    + + G TP++ +A  GH
Sbjct: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGH 731

Query: 165 LAAVEVLLKLGA 176
           +  +  LL+  A
Sbjct: 732 IGVLGALLQSAA 743



 Score = 32.7 bits (73), Expect = 0.76
 Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 5/74 (6%)

Query: 141 LGAS-PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LD 195
           LGAS  N+  + G TPL+ AAF  H+  +++LL   A        G TP  +A+     +
Sbjct: 811 LGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTN 870

Query: 196 TVVSVLRSWDLSLT 209
           TV  ++ S    LT
Sbjct: 871 TVEMLVSSASAELT 884



 Score = 30.8 bits (68), Expect = 2.9
 Identities = 34/116 (29%), Positives = 53/116 (45%), Gaps = 12/116 (10%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKG-AFGP 153
           GH +A E   L + +   +  +S G TPL  AA  G    + +    GAS   K      
Sbjct: 561 GHHQALEV--LVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKR 618

Query: 154 TPLYRAAFGGHLAAVEVLLKLGADPR----VYAEDGSTPERVASL----DTVVSVL 201
           TP++ AA  GH   + +L+   A+P+    +   +G TP  ++ L    D V S+L
Sbjct: 619 TPIHAAATNGHSECLRLLIG-NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 673



 Score = 30.4 bits (67), Expect = 3.8
 Identities = 23/78 (29%), Positives = 34/78 (43%)

Query: 110 ALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVE 169
           A    +DS   TPL  A A     A+Q+  +  A  N++     TPL+ AA    +   E
Sbjct: 65  ARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAE 124

Query: 170 VLLKLGADPRVYAEDGST 187
            L+ L ++  V    G T
Sbjct: 125 ALVPLLSNVNVSDRAGRT 142



 Score = 29.6 bits (65), Expect = 6.4
 Identities = 30/98 (30%), Positives = 41/98 (41%), Gaps = 7/98 (7%)

Query: 98  EAGEARRLQRRVALAECE----DSYGNTPLSEAAAGGQPLAIQLRAELGASPN---SKGA 150
           E G+   ++  V+ A  E    D+  NT L  A + G   +  L  E     N   +  A
Sbjct: 865 ENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNA 924

Query: 151 FGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTP 188
              TPL+ AA  G    V+ LL  GA      E+G TP
Sbjct: 925 ALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 46/152 (30%), Positives = 71/152 (46%), Gaps = 20/152 (13%)

Query: 47  AARAIQGAFRQLRARRELARRREERREYLEQMETPQKEVEQLLTREGVG------HDEAG 100
           AA A++ A R+L    E  R  +  R  ++++ TP+K    + +R+  G      H  AG
Sbjct: 17  AAEAVEPAARELF---EACRNGDVER--VKRLVTPEK----VNSRDTAGRKSTPLHFAAG 67

Query: 101 EARR-----LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTP 155
             R+     L +  A  +  D  G  PL  A + G    + L    GA PN++  +  TP
Sbjct: 68  FGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTP 127

Query: 156 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGST 187
           L+ AA  G +    VLL+ GA+P +   DG T
Sbjct: 128 LHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRT 159



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 33/107 (30%), Positives = 49/107 (45%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           G++    A  L +  A    +D  G  PL  AA+ G      L  +  A  N+   +  T
Sbjct: 688 GYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFT 747

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 201
           PL+ AA  G      +LL  GADP +  ++G TP  + S D V ++L
Sbjct: 748 PLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 36/118 (30%), Positives = 53/118 (44%), Gaps = 1/118 (0%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           G++       L +  A    +D  G  PL  A + G     +L  + GA  N    +  T
Sbjct: 535 GYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFT 594

Query: 155 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTP-ERVASLDTVVSVLRSWDLSLTEA 211
           PL+ AA  G     ++LL+ GADP     DG+TP + V   DT +  L   D +L +A
Sbjct: 595 PLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDA 652



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 28/98 (28%), Positives = 46/98 (46%)

Query: 121 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 180
           TPL  A+       +++  +  A  N+    G T L+RAA+ GHL    +LL  G DP +
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461

Query: 181 YAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEA 218
            +  G T  ++ + +    +     L  +EA  Q +EA
Sbjct: 462 ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEA 499



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 31/105 (29%), Positives = 49/105 (46%), Gaps = 4/105 (3%)

Query: 100 GEARRLQRRVA--LAECEDSYG--NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTP 155
           G+  R++R V        D+ G  +TPL  AA  G+   ++   + GA+  ++   G  P
Sbjct: 35  GDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIP 94

Query: 156 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSV 200
           L+ A   GH   V +LL+ GADP        TP   A++   + V
Sbjct: 95  LHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDV 139



 Score = 36.6 bits (83), Expect = 0.052
 Identities = 33/115 (28%), Positives = 54/115 (46%), Gaps = 17/115 (14%)

Query: 78  METPQKEVEQLLTREGV--GHDEA----------GEARRLQR--RVALAECEDSYG--NT 121
           ++   + V+QLL +EG+  G+ EA          G+   +++   V    C D  G  +T
Sbjct: 470 LQMGNENVQQLL-QEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQST 528

Query: 122 PLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGA 176
           PL  AA   +   ++   + GA  ++K   G  PL+ A   GH    E+L+K GA
Sbjct: 529 PLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGA 583



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 28/97 (28%), Positives = 43/97 (44%), Gaps = 1/97 (1%)

Query: 80  TPQKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRA 139
           T + + ++LL     G++E   A      V      D   +TPL  AA   +   +QL  
Sbjct: 173 TGEYKKDELLESARSGNEEKMMALLTPLNVN-CHASDGRKSTPLHLAAGYNRVKIVQLLL 231

Query: 140 ELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGA 176
           + GA  ++K      PL+ A   GH    E+L+K GA
Sbjct: 232 QHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGA 268



 Score = 33.1 bits (74), Expect = 0.58
 Identities = 23/84 (27%), Positives = 36/84 (42%)

Query: 95  GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 154
           G++     + L +  A    +D     PL  A + G     +L  + GA  N+   +  T
Sbjct: 220 GYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFT 279

Query: 155 PLYRAAFGGHLAAVEVLLKLGADP 178
           PL+ AA    +    +LL  GADP
Sbjct: 280 PLHEAASKNRVEVCSLLLSYGADP 303


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 89/374 (23%), Positives = 151/374 (40%), Gaps = 39/374 (10%)

Query: 28   ELRARRGS----------QDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQ 77
            ELR R G           Q  R + A ++   A++    +LRA  EL+  +  R+E  ++
Sbjct: 1221 ELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA--ELSSLQTARQEGEQR 1278

Query: 78   METPQKEVEQLLTREGVGHDEAGEA-RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQ 136
                + +++++  R G G     EA  +LQR  A AE E+  G   L+EA +    L+ +
Sbjct: 1279 RRRLELQLQEVQGRAGDGERARAEAAEKLQR--AQAELENVSG--ALNEAESKTIRLSKE 1334

Query: 137  LRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDT 196
            L +      +++         + A G  + A+E     G   ++  E  +       L T
Sbjct: 1335 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAA-GLREQLEEEAAARERAGRELQT 1393

Query: 197  VVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTR---EQQQCH 253
              + L  W         Q  EA      +EA+R    EAE +T ++ + T      ++  
Sbjct: 1394 AQAQLSEW------RRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR 1447

Query: 254  KELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAE------E 307
            + LQQ   + +  + +  Q       K +   Q + + +A V R  +E ++AE      E
Sbjct: 1448 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1507

Query: 308  ALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMK---DVGNRIRADGRWPLVIDPLGQ 364
            A A++     E+ QE  EE       +    + L+    DVG  +    R   V +   Q
Sbjct: 1508 ARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAE---Q 1564

Query: 365  AATFLRYQDTNYVD 378
            AA  LR Q T   D
Sbjct: 1565 AANDLRAQVTELED 1578



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 88/368 (23%), Positives = 135/368 (36%), Gaps = 56/368 (15%)

Query: 9    REGCPAGDSTPSSPFLGAPELRARRGSQDPRRRPAEDRAARA------IQG-AFRQLRAR 61
            R G  A + T  +      ELRA   S    R+  E R  R       +QG A    RAR
Sbjct: 1241 RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERAR 1300

Query: 62   RELARRREERREYLEQMETPQKEVE--------QLLTREGVGHD-------EAGEARRLQ 106
             E A + +  +  LE +     E E        +L + E   HD       E      L 
Sbjct: 1301 AEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALG 1360

Query: 107  RRVALAECEDSYGNTPLSEAAAGGQPLAIQLRA--------------ELGASPNSKGAFG 152
             RV   E E +     L E AA  +    +L+               E GA    + A  
Sbjct: 1361 SRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARR 1420

Query: 153  PTPLYRAAFGGHLAA-VEVLLKLGADPRVYAE--DGST---PERVASLDTVVSVLRSWDL 206
                   A    LA   E + +L    R   +  D +T    ++   + T+    R +D 
Sbjct: 1421 RAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQ 1480

Query: 207  SLTEAMLQNMEAEQQRRAQEAQ-RHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSR 265
             L E     + A ++R   EA+ R +EA A  +T  +++    +++  ++ +    EL  
Sbjct: 1481 LLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEA 1540

Query: 266  RISEHD-------QCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELRE 318
             +S  D       + E  C    ++  QA  D  AQV  L  E   AE+  A  RLE+  
Sbjct: 1541 LLSSKDDVGKSVHELERAC----RVAEQAANDLRAQVTELEDELTAAED--AKLRLEVTV 1594

Query: 319  QTQEGEEE 326
            Q  + + E
Sbjct: 1595 QALKTQHE 1602



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 48/193 (24%), Positives = 90/193 (46%), Gaps = 33/193 (17%)

Query: 173  KLGADPRVYAEDGSTPERVAS----LDTVVSVLRSWDLSLTEAMLQNMEAEQQR---RAQ 225
            +L A+  + AE   T  R+A+    L+ VVS L +  +   E   + M+ E++R     Q
Sbjct: 920  QLRAEAELCAEAEETRGRLAARKQELELVVSELEA-RVGEEEECSRQMQTEKKRLQQHIQ 978

Query: 226  EAQRHKEAE-AERMTLKVQQLTREQQQC-------------------HKELQQAYCELSR 265
            E + H EAE   R  L+++++T E +                      K L+    E S 
Sbjct: 979  ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1038

Query: 266  RISEHDQCEWRCMDKTKLTLQA----IKDTEAQVDRLRQEAQKAEEALAMARLELREQTQ 321
            + +E ++ + + ++K +L  +A    ++D   + ++ RQE +K +  L     EL+EQ  
Sbjct: 1039 QAAEEEE-KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMV 1097

Query: 322  EGEEEAPGLKCQV 334
            E ++ A  L+ Q+
Sbjct: 1098 EQQQRAEELRAQL 1110



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 80/317 (25%), Positives = 124/317 (39%), Gaps = 39/317 (12%)

Query: 28   ELRARRGSQDPRRRPAED--RAARAIQGAFRQLRAR-RELARRREERREYLEQMETPQKE 84
            EL A   S+D   +   +  RA R  + A   LRA+  EL        +   ++E   + 
Sbjct: 1537 ELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQA 1596

Query: 85   VEQLLTREGVGHDEAGEARR--LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELG 142
            ++    R+  G DEAGE RR  L +++  AE E        + A A  + L  +L  EL 
Sbjct: 1597 LKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELE-ELK 1655

Query: 143  ASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP----RVYAEDGSTPERVASLDTVV 198
            A   S G             G   AV+ L K+ A      R   E  ++ E + S +   
Sbjct: 1656 AQMASAGQ------------GKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNR-E 1702

Query: 199  SVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERM---TLKVQQLTREQQQCHKE 255
            S  R   L      LQ   A   R  ++AQ+ ++  A+ +    L    +  E++Q    
Sbjct: 1703 SEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGR 1762

Query: 256  LQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLE 315
            L Q   EL    S  +       D+ +  L  ++    ++   R  + KAE      R +
Sbjct: 1763 LGQLEEELEEEQSNSELLN----DRYRKLLLQVESLTTELSAERSFSAKAES----GRQQ 1814

Query: 316  LREQTQE-----GEEEA 327
            L  Q QE     GEE+A
Sbjct: 1815 LERQIQELRGRLGEEDA 1831



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 14/115 (12%)

Query: 210  EAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISE 269
            +  +  +E E+ R A++ +   E  AE    + +   R+Q     EL+    EL  R+ E
Sbjct: 904  QGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQ-----ELELVVSELEARVGE 958

Query: 270  HDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 324
             ++C  +   + K   Q I++ EA ++        AEE  A  +L+L + T E +
Sbjct: 959  EEECSRQMQTEKKRLQQHIQELEAHLE--------AEEG-ARQKLQLEKVTTEAK 1004



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 72/355 (20%), Positives = 139/355 (39%), Gaps = 56/355 (15%)

Query: 26   APELRARRGSQDPRR--RPAEDRAARAIQGAFRQLRARRELARR-REERREYLEQMETPQ 82
            A +LR     +D  R  R     A + ++G   +L+A+   A + +EE  + L +M+   
Sbjct: 1620 AKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQM 1679

Query: 83   KEVEQLLTREGVGHDEA-GEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAEL 141
            KE+ + +       +E   + R  ++R+   E E                   ++L+ EL
Sbjct: 1680 KELWREVEETRTSREEIFSQNRESEKRLKGLEAE------------------VLRLQEEL 1721

Query: 142  GASPNSK--GAFGPTPLYRAAFGGHLAAVEVLL-------KLGADPRVYAEDGSTPE--- 189
             AS  ++         +      G+L+   +L        +LG       E+ S  E   
Sbjct: 1722 AASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLN 1781

Query: 190  --------RVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQ-------RHK--- 231
                    +V SL T +S  RS+         Q     Q+ R +  +       RHK   
Sbjct: 1782 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTI 1841

Query: 232  ---EAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAI 288
               E++  +   +++Q TRE+    K +++A   L   + + ++ E R  D+ +  L+  
Sbjct: 1842 AALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEE-ERRVADQLRDQLEKG 1900

Query: 289  KDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMK 343
                 Q+ R  +EA++        R  L+ + ++  E A  +  +VT L + L +
Sbjct: 1901 NLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1955



 Score = 30.8 bits (68), Expect = 2.9
 Identities = 64/278 (23%), Positives = 97/278 (34%), Gaps = 61/278 (21%)

Query: 65   ARRREERREYLEQM----ETPQKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGN 120
            A   EE+ + L ++    E    ++E  L +E  G  E     +L+RR+     E     
Sbjct: 1040 AAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL---EKLKRRLDGESSE----- 1091

Query: 121  TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 180
              L E     Q  A +LRA+LG       A                         A  R 
Sbjct: 1092 --LQEQMVEQQQRAEELRAQLGRKEEELQA-------------------------ALARA 1124

Query: 181  YAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTL 240
              E G+  + + SL    + L      L    +   +AE+QRR       +E EA R  L
Sbjct: 1125 EDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR----DLGEELEALRGEL 1180

Query: 241  K-VQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLR 299
            +     T  QQ+   + +Q   EL + + E  +                   EA V  LR
Sbjct: 1181 EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIH-----------------EAAVQELR 1223

Query: 300  QEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTEL 337
            Q   +A   LA    + R      E+    L+ +V+EL
Sbjct: 1224 QRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1261


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 89/374 (23%), Positives = 151/374 (40%), Gaps = 39/374 (10%)

Query: 28   ELRARRGS----------QDPRRRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQ 77
            ELR R G           Q  R + A ++   A++    +LRA  EL+  +  R+E  ++
Sbjct: 1213 ELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA--ELSSLQTARQEGEQR 1270

Query: 78   METPQKEVEQLLTREGVGHDEAGEA-RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQ 136
                + +++++  R G G     EA  +LQR  A AE E+  G   L+EA +    L+ +
Sbjct: 1271 RRRLELQLQEVQGRAGDGERARAEAAEKLQR--AQAELENVSG--ALNEAESKTIRLSKE 1326

Query: 137  LRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDT 196
            L +      +++         + A G  + A+E     G   ++  E  +       L T
Sbjct: 1327 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAA-GLREQLEEEAAARERAGRELQT 1385

Query: 197  VVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTR---EQQQCH 253
              + L  W         Q  EA      +EA+R    EAE +T ++ + T      ++  
Sbjct: 1386 AQAQLSEW------RRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR 1439

Query: 254  KELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAE------E 307
            + LQQ   + +  + +  Q       K +   Q + + +A V R  +E ++AE      E
Sbjct: 1440 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1499

Query: 308  ALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMK---DVGNRIRADGRWPLVIDPLGQ 364
            A A++     E+ QE  EE       +    + L+    DVG  +    R   V +   Q
Sbjct: 1500 ARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAE---Q 1556

Query: 365  AATFLRYQDTNYVD 378
            AA  LR Q T   D
Sbjct: 1557 AANDLRAQVTELED 1570



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 88/368 (23%), Positives = 135/368 (36%), Gaps = 56/368 (15%)

Query: 9    REGCPAGDSTPSSPFLGAPELRARRGSQDPRRRPAEDRAARA------IQG-AFRQLRAR 61
            R G  A + T  +      ELRA   S    R+  E R  R       +QG A    RAR
Sbjct: 1233 RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERAR 1292

Query: 62   RELARRREERREYLEQMETPQKEVE--------QLLTREGVGHD-------EAGEARRLQ 106
             E A + +  +  LE +     E E        +L + E   HD       E      L 
Sbjct: 1293 AEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALG 1352

Query: 107  RRVALAECEDSYGNTPLSEAAAGGQPLAIQLRA--------------ELGASPNSKGAFG 152
             RV   E E +     L E AA  +    +L+               E GA    + A  
Sbjct: 1353 SRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARR 1412

Query: 153  PTPLYRAAFGGHLAA-VEVLLKLGADPRVYAE--DGST---PERVASLDTVVSVLRSWDL 206
                   A    LA   E + +L    R   +  D +T    ++   + T+    R +D 
Sbjct: 1413 RAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQ 1472

Query: 207  SLTEAMLQNMEAEQQRRAQEAQ-RHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSR 265
             L E     + A ++R   EA+ R +EA A  +T  +++    +++  ++ +    EL  
Sbjct: 1473 LLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEA 1532

Query: 266  RISEHD-------QCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELRE 318
             +S  D       + E  C    ++  QA  D  AQV  L  E   AE+  A  RLE+  
Sbjct: 1533 LLSSKDDVGKSVHELERAC----RVAEQAANDLRAQVTELEDELTAAED--AKLRLEVTV 1586

Query: 319  QTQEGEEE 326
            Q  + + E
Sbjct: 1587 QALKTQHE 1594



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 48/193 (24%), Positives = 90/193 (46%), Gaps = 33/193 (17%)

Query: 173  KLGADPRVYAEDGSTPERVAS----LDTVVSVLRSWDLSLTEAMLQNMEAEQQR---RAQ 225
            +L A+  + AE   T  R+A+    L+ VVS L +  +   E   + M+ E++R     Q
Sbjct: 912  QLRAEAELCAEAEETRGRLAARKQELELVVSELEA-RVGEEEECSRQMQTEKKRLQQHIQ 970

Query: 226  EAQRHKEAE-AERMTLKVQQLTREQQQC-------------------HKELQQAYCELSR 265
            E + H EAE   R  L+++++T E +                      K L+    E S 
Sbjct: 971  ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1030

Query: 266  RISEHDQCEWRCMDKTKLTLQA----IKDTEAQVDRLRQEAQKAEEALAMARLELREQTQ 321
            + +E ++ + + ++K +L  +A    ++D   + ++ RQE +K +  L     EL+EQ  
Sbjct: 1031 QAAEEEE-KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMV 1089

Query: 322  EGEEEAPGLKCQV 334
            E ++ A  L+ Q+
Sbjct: 1090 EQQQRAEELRAQL 1102



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 80/317 (25%), Positives = 124/317 (39%), Gaps = 39/317 (12%)

Query: 28   ELRARRGSQDPRRRPAED--RAARAIQGAFRQLRAR-RELARRREERREYLEQMETPQKE 84
            EL A   S+D   +   +  RA R  + A   LRA+  EL        +   ++E   + 
Sbjct: 1529 ELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQA 1588

Query: 85   VEQLLTREGVGHDEAGEARR--LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELG 142
            ++    R+  G DEAGE RR  L +++  AE E        + A A  + L  +L  EL 
Sbjct: 1589 LKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELE-ELK 1647

Query: 143  ASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP----RVYAEDGSTPERVASLDTVV 198
            A   S G             G   AV+ L K+ A      R   E  ++ E + S +   
Sbjct: 1648 AQMASAGQ------------GKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNR-E 1694

Query: 199  SVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERM---TLKVQQLTREQQQCHKE 255
            S  R   L      LQ   A   R  ++AQ+ ++  A+ +    L    +  E++Q    
Sbjct: 1695 SEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGR 1754

Query: 256  LQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLE 315
            L Q   EL    S  +       D+ +  L  ++    ++   R  + KAE      R +
Sbjct: 1755 LGQLEEELEEEQSNSELLN----DRYRKLLLQVESLTTELSAERSFSAKAES----GRQQ 1806

Query: 316  LREQTQE-----GEEEA 327
            L  Q QE     GEE+A
Sbjct: 1807 LERQIQELRGRLGEEDA 1823



 Score = 35.8 bits (81), Expect = 0.089
 Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 14/115 (12%)

Query: 210 EAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISE 269
           +  +  +E E+ R A++ +   E  AE    + +   R+Q     EL+    EL  R+ E
Sbjct: 896 QGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQ-----ELELVVSELEARVGE 950

Query: 270 HDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 324
            ++C  +   + K   Q I++ EA ++        AEE  A  +L+L + T E +
Sbjct: 951 EEECSRQMQTEKKRLQQHIQELEAHLE--------AEEG-ARQKLQLEKVTTEAK 996



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 72/355 (20%), Positives = 139/355 (39%), Gaps = 56/355 (15%)

Query: 26   APELRARRGSQDPRR--RPAEDRAARAIQGAFRQLRARRELARR-REERREYLEQMETPQ 82
            A +LR     +D  R  R     A + ++G   +L+A+   A + +EE  + L +M+   
Sbjct: 1612 AKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQM 1671

Query: 83   KEVEQLLTREGVGHDEA-GEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAEL 141
            KE+ + +       +E   + R  ++R+   E E                   ++L+ EL
Sbjct: 1672 KELWREVEETRTSREEIFSQNRESEKRLKGLEAE------------------VLRLQEEL 1713

Query: 142  GASPNSK--GAFGPTPLYRAAFGGHLAAVEVLL-------KLGADPRVYAEDGSTPE--- 189
             AS  ++         +      G+L+   +L        +LG       E+ S  E   
Sbjct: 1714 AASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLN 1773

Query: 190  --------RVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQ-------RHK--- 231
                    +V SL T +S  RS+         Q     Q+ R +  +       RHK   
Sbjct: 1774 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTI 1833

Query: 232  ---EAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAI 288
               E++  +   +++Q TRE+    K +++A   L   + + ++ E R  D+ +  L+  
Sbjct: 1834 AALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEE-ERRVADQLRDQLEKG 1892

Query: 289  KDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMK 343
                 Q+ R  +EA++        R  L+ + ++  E A  +  +VT L + L +
Sbjct: 1893 NLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1947



 Score = 30.8 bits (68), Expect = 2.9
 Identities = 64/278 (23%), Positives = 97/278 (34%), Gaps = 61/278 (21%)

Query: 65   ARRREERREYLEQM----ETPQKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGN 120
            A   EE+ + L ++    E    ++E  L +E  G  E     +L+RR+     E     
Sbjct: 1032 AAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL---EKLKRRLDGESSE----- 1083

Query: 121  TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 180
              L E     Q  A +LRA+LG       A                         A  R 
Sbjct: 1084 --LQEQMVEQQQRAEELRAQLGRKEEELQA-------------------------ALARA 1116

Query: 181  YAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTL 240
              E G+  + + SL    + L      L    +   +AE+QRR       +E EA R  L
Sbjct: 1117 EDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR----DLGEELEALRGEL 1172

Query: 241  K-VQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLR 299
            +     T  QQ+   + +Q   EL + + E  +                   EA V  LR
Sbjct: 1173 EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIH-----------------EAAVQELR 1215

Query: 300  QEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTEL 337
            Q   +A   LA    + R      E+    L+ +V+EL
Sbjct: 1216 QRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1253


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,261,662
Number of Sequences: 37866
Number of extensions: 935534
Number of successful extensions: 9702
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 363
Number of HSP's successfully gapped in prelim test: 552
Number of HSP's that attempted gapping in prelim test: 5465
Number of HSP's gapped (non-prelim): 3771
length of query: 484
length of database: 18,247,518
effective HSP length: 106
effective length of query: 378
effective length of database: 14,233,722
effective search space: 5380346916
effective search space used: 5380346916
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.