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Search of human proteins with 239754321
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239754321 PREDICTED: similar to ankyrin repeat domain 2
[Homo sapiens]
(245 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239754321 PREDICTED: similar to ankyrin repeat domain 2 [Homo... 508 e-144
gi|241896857 hypothetical protein LOC100287718 [Homo sapiens] 459 e-129
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 80 1e-15
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 79 4e-15
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 77 1e-14
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 76 3e-14
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 71 1e-12
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 71 1e-12
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 71 1e-12
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 71 1e-12
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 71 1e-12
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 69 5e-12
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 69 5e-12
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 69 5e-12
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 68 8e-12
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens] 65 5e-11
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 63 3e-10
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun... 62 5e-10
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit... 62 5e-10
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 62 5e-10
gi|20270347 ankyrin repeat domain 54 [Homo sapiens] 61 8e-10
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso... 60 1e-09
gi|30089994 ankyrin repeat and SOCS box-containing protein 7 iso... 60 1e-09
gi|34304383 Usher syndrome 1G protein [Homo sapiens] 60 1e-09
gi|10863929 ribonuclease L [Homo sapiens] 60 2e-09
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 60 2e-09
gi|103471993 huntingtin interacting protein 14 [Homo sapiens] 60 2e-09
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 60 2e-09
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 59 3e-09
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 59 5e-09
>gi|239754321 PREDICTED: similar to ankyrin repeat domain 2 [Homo
sapiens]
Length = 245
Score = 508 bits (1308), Expect = e-144
Identities = 245/245 (100%), Positives = 245/245 (100%)
Query: 1 MVRTACQHRAPQISHKTGCSHISMHSPGGLTTTKMAGPLPRVSDSLFSAMELAKMSDMTK 60
MVRTACQHRAPQISHKTGCSHISMHSPGGLTTTKMAGPLPRVSDSLFSAMELAKMSDMTK
Sbjct: 1 MVRTACQHRAPQISHKTGCSHISMHSPGGLTTTKMAGPLPRVSDSLFSAMELAKMSDMTK 60
Query: 61 LHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPC 120
LHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPC
Sbjct: 61 LHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPC 120
Query: 121 LVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEK 180
LVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEK
Sbjct: 121 LVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEK 180
Query: 181 AEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMNKKNKKSRGPTRPSNT 240
AEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMNKKNKKSRGPTRPSNT
Sbjct: 181 AEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMNKKNKKSRGPTRPSNT 240
Query: 241 KGRRV 245
KGRRV
Sbjct: 241 KGRRV 245
>gi|241896857 hypothetical protein LOC100287718 [Homo sapiens]
Length = 222
Score = 459 bits (1181), Expect = e-129
Identities = 222/222 (100%), Positives = 222/222 (100%)
Query: 24 MHSPGGLTTTKMAGPLPRVSDSLFSAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCD 83
MHSPGGLTTTKMAGPLPRVSDSLFSAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCD
Sbjct: 1 MHSPGGLTTTKMAGPLPRVSDSLFSAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCD 60
Query: 84 PNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILK 143
PNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILK
Sbjct: 61 PNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILK 120
Query: 144 TLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKGLPLDERD 203
TLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKGLPLDERD
Sbjct: 121 TLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKGLPLDERD 180
Query: 204 EDWDAKKRELELSLPSLNQNMNKKNKKSRGPTRPSNTKGRRV 245
EDWDAKKRELELSLPSLNQNMNKKNKKSRGPTRPSNTKGRRV
Sbjct: 181 EDWDAKKRELELSLPSLNQNMNKKNKKSRGPTRPSNTKGRRV 222
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 80.5 bits (197), Expect = 1e-15
Identities = 48/130 (36%), Positives = 65/130 (50%), Gaps = 3/130 (2%)
Query: 46 LFSAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQ 105
L S++ ++ T LH A G +V +L KG N D DR LHWAA G
Sbjct: 104 LLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGA---NINAFDKKDRRALHWAAYMGH 160
Query: 106 MEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRI 165
++V+ LLI +GA G+TP H AA G +N++K L L ID + +G+T I
Sbjct: 161 LDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHI 220
Query: 166 AQIYGQKACV 175
A GQ A V
Sbjct: 221 ACYNGQDAVV 230
Score = 50.8 bits (120), Expect = 1e-06
Identities = 35/114 (30%), Positives = 57/114 (50%), Gaps = 4/114 (3%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A + G ++VK +L G+ +++ T LH A GQ V+ LI+YGA
Sbjct: 183 TPLHAAASNGQINVVKHLLNLGV---EIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
Query: 119 PCLVTSVGWTPAHFAAEAGHLNI-LKTLHALHAAIDAPDFFGDTPKRIAQIYGQ 171
+ G+TP HFAA + H + L+ L A ++ G +P + ++G+
Sbjct: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGR 293
Score = 47.4 bits (111), Expect = 1e-05
Identities = 33/101 (32%), Positives = 45/101 (44%), Gaps = 5/101 (4%)
Query: 94 RTPLHWAAIKGQMEVIRLLIEYGARPCLVT---SVGWTPAHFAAEAGHLNILKTLHALHA 150
RTPLH + I G +RLL+E P V + G TP A GH++ + L A
Sbjct: 610 RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEA 669
Query: 151 AIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPE--CQDHR 189
+D D G T + G + CV L + E C+D R
Sbjct: 670 NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSR 710
Score = 47.0 bits (110), Expect = 2e-05
Identities = 43/156 (27%), Positives = 59/156 (37%), Gaps = 35/156 (22%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A A+ +L ++L D N + D ++PLH A+ G+ + LI+ G
Sbjct: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKD--GKSPLHMTAVHGRFTRSQTLIQNGGE 306
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHA---------------LHAA------------ 151
V G TP H AA GH ++ TL LH A
Sbjct: 307 IDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKL 366
Query: 152 ------IDAPDFFGDTPKRIAQIYGQKACVAFLEKA 181
ID PD FG T A G C+ L+ +
Sbjct: 367 LSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSS 402
Score = 45.4 bits (106), Expect = 4e-05
Identities = 41/135 (30%), Positives = 56/135 (41%), Gaps = 10/135 (7%)
Query: 49 AMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEV 108
A+++ T L AVA G V +L+K + N VD T LH + G E
Sbjct: 637 AVDVKDAKGQTPLMLAVAYGHIDAVSLLLEK---EANVDTVDILGCTALHRGIMTGHEEC 693
Query: 109 IRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFF-----GDTPK 163
+++L+E S G TP H+AA GH L L L A+ D G TP
Sbjct: 694 VQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSEL--LQMALSEEDCCFKDNQGYTPL 751
Query: 164 RIAQIYGQKACVAFL 178
A G + C+ L
Sbjct: 752 HWACYNGNENCIEVL 766
Score = 45.1 bits (105), Expect = 6e-05
Identities = 36/124 (29%), Positives = 51/124 (41%), Gaps = 7/124 (5%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A A G + + ++L+ L + + D TPLHWA G I +L+E +
Sbjct: 713 TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE---Q 769
Query: 119 PCLVTSVG--WTPAHFAAEAGHLNILKTLHAL--HAAIDAPDFFGDTPKRIAQIYGQKAC 174
C +G +TP H A H N L + + D G TP R A C
Sbjct: 770 KCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVEC 829
Query: 175 VAFL 178
+ L
Sbjct: 830 LQLL 833
Score = 44.3 bits (103), Expect = 1e-04
Identities = 35/107 (32%), Positives = 48/107 (44%), Gaps = 9/107 (8%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWND---RTPLHWAAIKGQMEVIRLLIE 114
M LH A +K+L G ++D D RT LH AA G +E I+LL
Sbjct: 348 MFPLHLAALNAHSDCCRKLLSSGF------EIDTPDKFGRTCLHAAAAGGNVECIKLLQS 401
Query: 115 YGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDT 161
GA G TP H+AA H + ++TL A ++ D +G T
Sbjct: 402 SGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRT 448
Score = 42.0 bits (97), Expect = 5e-04
Identities = 28/78 (35%), Positives = 38/78 (48%)
Query: 89 VDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHAL 148
+D RTPLH AA G E+I LLI GAR ++ TP H A + ++ L
Sbjct: 12 LDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKH 71
Query: 149 HAAIDAPDFFGDTPKRIA 166
A ++A D TP +A
Sbjct: 72 SADVNARDKNWQTPLHVA 89
Score = 37.7 bits (86), Expect = 0.009
Identities = 25/76 (32%), Positives = 33/76 (43%), Gaps = 3/76 (3%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A A G+ +K + G ++ D RTPLH+AA I L+ GA
Sbjct: 382 TCLHAAAAGGNVECIKLLQSSGA---DFHKKDKCGRTPLHYAAANCHFHCIETLVTTGAN 438
Query: 119 PCLVTSVGWTPAHFAA 134
G T H+AA
Sbjct: 439 VNETDDWGRTALHYAA 454
Score = 35.8 bits (81), Expect = 0.035
Identities = 29/97 (29%), Positives = 45/97 (46%), Gaps = 2/97 (2%)
Query: 90 DWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTL-HAL 148
D RTPL AA +E ++LL+ + A V + G T AAE G + L ++
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 149 HAAIDAPDFFGDTPKRIAQIYGQKAC-VAFLEKAEPE 184
A + D +TP +A G + C + L+K + E
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDE 907
Score = 33.5 bits (75), Expect = 0.17
Identities = 29/98 (29%), Positives = 38/98 (38%), Gaps = 2/98 (2%)
Query: 83 DPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWT--PAHFAAEAGHLN 140
D N D +H+AA G + + LL+E + G T P H AA GH
Sbjct: 497 DANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQ 556
Query: 141 ILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
L+ L +D D G T +A G CV L
Sbjct: 557 ALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 79.0 bits (193), Expect = 4e-15
Identities = 43/130 (33%), Positives = 69/130 (53%), Gaps = 3/130 (2%)
Query: 46 LFSAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQ 105
L S + ++ + T LH A +G +VK +L +G N D DR +HWAA G
Sbjct: 129 LLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGA---NINAFDKKDRRAIHWAAYMGH 185
Query: 106 MEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRI 165
+EV++LL+ +GA +TP H AA +G ++++K L L ++ P+ +G+TP +
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
Query: 166 AQIYGQKACV 175
A GQ V
Sbjct: 246 ACYNGQDVVV 255
Score = 57.0 bits (136), Expect = 1e-08
Identities = 44/139 (31%), Positives = 64/139 (46%), Gaps = 7/139 (5%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQME 107
+A+++ + T L +V G V +L KG N D RT LH A+ G E
Sbjct: 644 NAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA---NVDAKDKWGRTALHRGAVTGHEE 700
Query: 108 VIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDA----PDFFGDTPK 163
+ L+++GA+ L S G TP H +A GH+ +L L A++DA D G T
Sbjct: 701 CVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTAL 760
Query: 164 RIAQIYGQKACVAFLEKAE 182
A G + CV L + E
Sbjct: 761 HWACYNGHETCVELLLEQE 779
Score = 51.2 bits (121), Expect = 8e-07
Identities = 42/117 (35%), Positives = 56/117 (47%), Gaps = 3/117 (2%)
Query: 50 MELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVI 109
M K+ D L QA+ GD V+ ++ K D N++D + RTPLH AA G E+I
Sbjct: 1 MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKE-DVNFQDNE--KRTPLHAAAYLGDAEII 57
Query: 110 RLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
LLI GAR S TP H A + ++ L A ++A D TP IA
Sbjct: 58 ELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIA 114
Score = 51.2 bits (121), Expect = 8e-07
Identities = 53/151 (35%), Positives = 67/151 (44%), Gaps = 37/151 (24%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A ++G S+VK +L G+ D N + N TPLH A GQ V+ LI+ GA
Sbjct: 208 TPLHAAASSGMISVVKYLLDLGV-DMNEPNAYGN--TPLHVACYNGQDVVVNELIDCGAI 264
Query: 119 PCLVTSVGWTPAHFAAEAGH----LNIL--------------KT-LH--ALH-------- 149
G+TP HFAA + H L +L KT LH ALH
Sbjct: 265 VNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQT 324
Query: 150 -----AAIDAPDFFGDTPKRIAQIYGQKACV 175
A ID D G+TP IA YG + +
Sbjct: 325 IIQSGAVIDCEDKNGNTPLHIAARYGHELLI 355
Score = 47.8 bits (112), Expect = 9e-06
Identities = 40/123 (32%), Positives = 51/123 (41%), Gaps = 9/123 (7%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGL---CDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEY 115
T LH G +S + I++ G C+ D N TPLH AA G +I LI
Sbjct: 308 TPLHMTALHGRFSRSQTIIQSGAVIDCE------DKNGNTPLHIAARYGHELLINTLITS 361
Query: 116 GARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACV 175
GA G P H AA +G + + L + ID PD FG T A G C+
Sbjct: 362 GADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECL 421
Query: 176 AFL 178
L
Sbjct: 422 NLL 424
Score = 46.2 bits (108), Expect = 3e-05
Identities = 40/152 (26%), Positives = 59/152 (38%), Gaps = 32/152 (21%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWND------------------------ 93
+T LH+AVA+ V+ +LK D N +D +W
Sbjct: 75 LTPLHRAVASCSEEAVQVLLKHS-ADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNV 133
Query: 94 -------RTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLH 146
RT LH AA G E+++LL+ GA H+AA GH+ ++K L
Sbjct: 134 NVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLV 193
Query: 147 ALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
+ A + D TP A G + V +L
Sbjct: 194 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYL 225
Score = 46.2 bits (108), Expect = 3e-05
Identities = 38/122 (31%), Positives = 59/122 (48%), Gaps = 7/122 (5%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
++ LH A G + ++ +L + L D + ++ + RTPL AA KG +E + +LI GA
Sbjct: 551 ISPLHLAAYHGHHQALE-VLVQSLLDLDVRNS--SGRTPLDLAAFKGHVECVDVLINQGA 607
Query: 118 RPCLVTSV-GWTPAHFAAEAGHLNILKTL---HALHAAIDAPDFFGDTPKRIAQIYGQKA 173
+ + TP H AA GH L+ L A+D D G TP ++ + G
Sbjct: 608 SILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTD 667
Query: 174 CV 175
CV
Sbjct: 668 CV 669
Score = 44.3 bits (103), Expect = 1e-04
Identities = 42/135 (31%), Positives = 63/135 (46%), Gaps = 9/135 (6%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIE-YGA 117
T LH A G + V+ +L++ + ++ + N +PLH A I +LI+ GA
Sbjct: 758 TALHWACYNGHETCVELLLEQEV----FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGA 813
Query: 118 RPCLVT-SVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVA 176
T S G TP H AA H+ L+ L + +A +++ D G TP +A GQ V
Sbjct: 814 SIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVE 873
Query: 177 FL---EKAEPECQDH 188
L AE QD+
Sbjct: 874 MLVSSASAELTLQDN 888
Score = 42.4 bits (98), Expect = 4e-04
Identities = 36/112 (32%), Positives = 49/112 (43%), Gaps = 9/112 (8%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWND---RTPLHWAAIKGQMEVIRLLIE 114
M LH A +G +K+L G D+D D RT LH AA G +E + LL+
Sbjct: 373 MFPLHLAALSGFSDCCRKLLSSGF------DIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426
Query: 115 YGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
GA G +P H+AA + L L A+++ D G TP A
Sbjct: 427 TGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478
Score = 42.4 bits (98), Expect = 4e-04
Identities = 31/96 (32%), Positives = 44/96 (45%), Gaps = 5/96 (5%)
Query: 94 RTPLHWAAIKGQMEVIRLLIEYGARPCLVTSV----GWTPAHFAAEAGHLNILKTLHALH 149
RTP+H AA G E +RLLI A P + G TP + GH + + +L
Sbjct: 618 RTPIHAAATNGHSECLRLLIG-NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKG 676
Query: 150 AAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPEC 185
A +DA D +G T + G + CV L + +C
Sbjct: 677 ANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKC 712
Score = 39.3 bits (90), Expect = 0.003
Identities = 31/110 (28%), Positives = 47/110 (42%), Gaps = 3/110 (2%)
Query: 57 DMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYG 116
D +H A G +VK ++ G + KD TPLH AA G + V++ L++ G
Sbjct: 173 DRRAIHWAAYMGHIEVVKLLVSHG-AEVTCKDK--KSYTPLHAAASSGMISVVKYLLDLG 229
Query: 117 ARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
+ G TP H A G ++ L A ++ + G TP A
Sbjct: 230 VDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFA 279
Score = 38.1 bits (87), Expect = 0.007
Identities = 36/126 (28%), Positives = 52/126 (41%), Gaps = 4/126 (3%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A A G+ + +L G D N KD R+PLH+AA + + L+ GA
Sbjct: 407 TCLHAAAAGGNLECLNLLLNTG-ADFNKKDKF--GRSPLHYAAANCNYQCLFALVGSGAS 463
Query: 119 PCLVTSVGWTPAHFAAEAG-HLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAF 177
+ G TP H+AA + L+ L A D G + YG + C+
Sbjct: 464 VNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQL 523
Query: 178 LEKAEP 183
+ P
Sbjct: 524 IASETP 529
Score = 35.0 bits (79), Expect = 0.059
Identities = 35/115 (30%), Positives = 53/115 (46%), Gaps = 7/115 (6%)
Query: 17 TGCSHISMHSPGGLTTTKMAGPLPRVSDSLFSAMELAKMSDMTKLHQAVAAGDYSLVKKI 76
TG + + M + G T T + + S + + L S T LH A + G + I
Sbjct: 855 TGKTPLMMAAENGQTNT-----VEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLI 909
Query: 77 LKKGLCDPNYKDV-DWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPA 130
L+K + D N + + +TPLH AA G V++ L+ GA V G+TPA
Sbjct: 910 LEK-ITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPA 963
Score = 29.6 bits (65), Expect = 2.5
Identities = 29/107 (27%), Positives = 44/107 (41%), Gaps = 5/107 (4%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T L A G + V+ ++ + +D N T LH A KG L++E
Sbjct: 858 TPLMMAAENGQTNTVEMLVSSASAELTLQDNSKN--TALHLACSKGHETSALLILEKITD 915
Query: 119 PCLVTSVG---WTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTP 162
L+ + TP H AA G +++ L A++ A D G TP
Sbjct: 916 RNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
Score = 29.3 bits (64), Expect = 3.3
Identities = 30/132 (22%), Positives = 49/132 (37%), Gaps = 14/132 (10%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A + + L + +P +D + +H++A G ++L+
Sbjct: 473 TPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNA--VHYSAAYGHRLCLQLIASETPL 530
Query: 119 PCLVTSVGW------------TPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
L+ + G +P H AA GH L+ L +D + G TP +A
Sbjct: 531 DVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLA 590
Query: 167 QIYGQKACVAFL 178
G CV L
Sbjct: 591 AFKGHVECVDVL 602
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 77.4 bits (189), Expect = 1e-14
Identities = 49/136 (36%), Positives = 69/136 (50%), Gaps = 3/136 (2%)
Query: 46 LFSAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQ 105
L S++ +A S + LH AV +G V +L KG + D +R PLHWAA G
Sbjct: 129 LLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGA---SLNVCDKKERQPLHWAAFLGH 185
Query: 106 MEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRI 165
+EV++LL+ GA G+ H AA +G + ++K L + A ID P+ FG+T I
Sbjct: 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245
Query: 166 AQIYGQKACVAFLEKA 181
A GQ A L A
Sbjct: 246 ACYLGQDAVAIELVNA 261
Score = 52.4 bits (124), Expect = 4e-07
Identities = 38/129 (29%), Positives = 60/129 (46%), Gaps = 3/129 (2%)
Query: 50 MELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVI 109
M + ++D L QA+ + D V+ +L + N +D RTPLH AA G + ++
Sbjct: 1 MGILSITDQPPLVQAIFSRDVEEVRSLLSQ---KENINVLDQERRTPLHAAAYVGDVPIL 57
Query: 110 RLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIY 169
+LL+ GA ++ TP H AA + + +L L A A ++A D TP +A
Sbjct: 58 QLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAAN 117
Query: 170 GQKACVAFL 178
C L
Sbjct: 118 RATKCAEAL 126
Score = 49.3 bits (116), Expect = 3e-06
Identities = 34/116 (29%), Positives = 53/116 (45%), Gaps = 2/116 (1%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A + + +L ++L D NY+ + ++PLH AAI G+ ++LI+ G+
Sbjct: 274 TPLHVAAVSTNGALCLELLVNNGADVNYQSKE--GKSPLHMAAIHGRFTRSQILIQNGSE 331
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKAC 174
G TP H AA GH ++ TL A P +A ++G C
Sbjct: 332 IDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDC 387
Score = 48.5 bits (114), Expect = 5e-06
Identities = 43/155 (27%), Positives = 66/155 (42%), Gaps = 35/155 (22%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLC-DPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYG- 116
T +H A A G ++++ +L+ L DP VD++ +P+HWA+ G + + LL+E+
Sbjct: 756 TPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSP 815
Query: 117 -----ARP-----CLV-----------------------TSVGWTPAHFAAEAGHLNILK 143
P C V + G TP H AA A +++ L+
Sbjct: 816 FSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLR 875
Query: 144 TLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
L A ++A D G T A GQ A V FL
Sbjct: 876 MLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910
Score = 44.7 bits (104), Expect = 7e-05
Identities = 37/123 (30%), Positives = 56/123 (45%), Gaps = 8/123 (6%)
Query: 59 TKLHQAVAAGDYSLVKKILKKG--LCDPNYKDVDWNDRTPLHWAAIKGQMEV-IRLLIEY 115
T LH A G ++ +++ G + PN K TPLH AA+ + + LL+
Sbjct: 241 TALHIACYLGQDAVAIELVNAGANVNQPNDKGF-----TPLHVAAVSTNGALCLELLVNN 295
Query: 116 GARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACV 175
GA + G +P H AA G + L + ID D FG+TP +A YG + +
Sbjct: 296 GADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLI 355
Query: 176 AFL 178
+ L
Sbjct: 356 STL 358
Score = 43.5 bits (101), Expect = 2e-04
Identities = 45/163 (27%), Positives = 61/163 (37%), Gaps = 21/163 (12%)
Query: 57 DMTKLHQAVAAGDYSLVKKILKKG--------LCDPNYKDVDWNDRTP-------LHWAA 101
DM LH AV G +K+L G L + + ++ TP LH AA
Sbjct: 372 DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAA 431
Query: 102 IKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDT 161
G +E + LL+ GA G TP H+AA G TL A ++ D G +
Sbjct: 432 SGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCS 491
Query: 162 PKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKGLPLDERDE 204
P A A +AEP A + + L R E
Sbjct: 492 PLHYA------AASDTYRRAEPHTPSSHDAEEDEPLKESRRKE 528
Score = 43.1 bits (100), Expect = 2e-04
Identities = 31/98 (31%), Positives = 43/98 (43%)
Query: 90 DWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALH 149
D + R+ LH A G +E + LL+ GA + P H+AA GHL +LK L A
Sbjct: 137 DRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARG 196
Query: 150 AAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPECQD 187
A + D G A GQ V +L + E +
Sbjct: 197 ADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDE 234
Score = 43.1 bits (100), Expect = 2e-04
Identities = 37/134 (27%), Positives = 56/134 (41%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQME 107
SA+ + T LH A A+G + ++ G +D +TPL A + G ++
Sbjct: 643 SALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVD 702
Query: 108 VIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQ 167
+ LL+E G+ G T H A G + L L A + DF G TP +A
Sbjct: 703 CVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLAS 762
Query: 168 IYGQKACVAFLEKA 181
G A + L +A
Sbjct: 763 ACGHTAVLRTLLQA 776
Score = 41.6 bits (96), Expect = 6e-04
Identities = 30/98 (30%), Positives = 45/98 (45%), Gaps = 4/98 (4%)
Query: 83 DPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIE--YGARPCLVTSVGWTPAHFAAEAGHLN 140
DP+ +D T +H+AA G + + LL+E + + +++ +P H AA GH
Sbjct: 542 DPSLRDRQ--GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCE 599
Query: 141 ILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
LKTL +D D G T +A G CV L
Sbjct: 600 ALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVL 637
Score = 41.2 bits (95), Expect = 8e-04
Identities = 36/118 (30%), Positives = 52/118 (44%), Gaps = 6/118 (5%)
Query: 45 SLFSAMELAKMSDM---TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAA 101
SL S E + D T LH A GD +++ +L G + N KD W TPLH AA
Sbjct: 26 SLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSG-ANVNAKDTLW--LTPLHRAA 82
Query: 102 IKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFG 159
+V+ LL+ + A + TP H AA + L L ++++ D G
Sbjct: 83 ASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSG 140
Score = 32.3 bits (72), Expect = 0.39
Identities = 29/107 (27%), Positives = 46/107 (42%), Gaps = 5/107 (4%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T L A G + V+ +L +G D +D N T LH A KG + +++
Sbjct: 893 TALMTAAENGQTAAVEFLLYRGKADLTV--LDENKNTALHLACSKGHEKCALMILAETQD 950
Query: 119 PCLVTSVGWT---PAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTP 162
L+ + P H AA G ++++ L + A + A D G TP
Sbjct: 951 LGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
Score = 30.8 bits (68), Expect = 1.1
Identities = 28/115 (24%), Positives = 40/115 (34%), Gaps = 31/115 (26%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAI---------------- 102
T LH A A G Y ++ G + D +PLH+AA
Sbjct: 458 TPLHYAAANGSYQCAVTLVTAGA---GVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHD 514
Query: 103 ------------KGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTL 145
K + L++ GA P L G+T H+AA G+ L+ L
Sbjct: 515 AEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELL 569
Score = 30.4 bits (67), Expect = 1.5
Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 4/122 (3%)
Query: 59 TKLHQAVAAGDYSLVKKILKK-GLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
T LH AV S + +L G N +D RTPLH AA + +R+L+++ A
Sbjct: 825 TPLHCAVINNQDSTTEMLLGALGAKIVNSRDA--KGRTPLHAAAFADNVSGLRMLLQHQA 882
Query: 118 RPCLVTSVGWTPAHFAAEAGHLNILK-TLHALHAAIDAPDFFGDTPKRIAQIYGQKACVA 176
G T AAE G ++ L+ A + D +T +A G + C
Sbjct: 883 EVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCAL 942
Query: 177 FL 178
+
Sbjct: 943 MI 944
Score = 29.6 bits (65), Expect = 2.5
Identities = 15/35 (42%), Positives = 19/35 (54%)
Query: 96 PLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPA 130
PLH AA G V++ L+ +GA V G TPA
Sbjct: 964 PLHIAARNGLASVVQALLSHGATVLAVDEEGHTPA 998
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 75.9 bits (185), Expect = 3e-14
Identities = 69/229 (30%), Positives = 105/229 (45%), Gaps = 22/229 (9%)
Query: 23 SMHSPGGLTTTKMAGPLPRVS-----DSLFSAMELAKMSDMTKLHQAVAAGDYSLVKKIL 77
++H G T +A VS S + ++ + + T LH AV G ++ +L
Sbjct: 488 NLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL 547
Query: 78 KKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAG 137
K G +D + PLH AA +G+ + ++L+ YGA L T GWTP H AA G
Sbjct: 548 KSGAVPDA---LDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKG 604
Query: 138 HLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKG- 196
HL I+ L HA + A TP +A +G++A V+ L +C AA+Q G
Sbjct: 605 HLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL----LQCGADPNAAEQSGW 660
Query: 197 LPLDERDEDWDAKKRELELSLPSL---NQNMNKKNKKSRGPTRPSNTKG 242
PL A +R LS+ +L + N++ +NK P + KG
Sbjct: 661 TPLHL------AVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKG 703
Score = 63.9 bits (154), Expect = 1e-10
Identities = 45/126 (35%), Positives = 63/126 (50%), Gaps = 5/126 (3%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVD-WNDRTPLHWAAIKGQMEVIRLLIEYGA 117
T LH A G+ ++V +L+ G DPN + W TPLH A + + L+E+ A
Sbjct: 628 TPLHLAARHGEEAVVSALLQCG-ADPNAAEQSGW---TPLHLAVQRSTFLSVINLLEHHA 683
Query: 118 RPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAF 177
VGWTPAH AA G+ ILK L A +D D TP ++A ++ ++F
Sbjct: 684 NVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSF 743
Query: 178 LEKAEP 183
LE EP
Sbjct: 744 LEGKEP 749
Score = 57.4 bits (137), Expect = 1e-08
Identities = 49/146 (33%), Positives = 65/146 (44%), Gaps = 12/146 (8%)
Query: 61 LHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPC 120
LH A GD + +L G C + W TPLH AA V RLL+ A P
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGW---TPLHLAAQNNFENVARLLVSRQADPN 488
Query: 121 LVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEK 180
L + G TP H AA GH++++K L + A +DA TP +A G+ + L K
Sbjct: 489 LHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548
Query: 181 --AEPECQD-------HRCAAQQKGL 197
A P+ D H AA+ K L
Sbjct: 549 SGAVPDALDQSGYGPLHTAAARGKYL 574
Score = 52.0 bits (123), Expect = 5e-07
Identities = 35/109 (32%), Positives = 50/109 (45%), Gaps = 5/109 (4%)
Query: 89 VDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHAL 148
VD + PLH+AA G RLL+++GA GWTP H AA+ N+ + L +
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
Query: 149 HAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKGL 197
A + + G TP +A +G + V L E AQQ+ L
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELD-----AQQRNL 527
Score = 46.6 bits (109), Expect = 2e-05
Identities = 38/112 (33%), Positives = 51/112 (45%), Gaps = 9/112 (8%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDR---TPLHWAAIKGQMEVIRLLIE 114
+T LH VA G V+ +L + DVD TPL AA Q ++ LL+
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEV------DVDCQTASGYTPLLIAAQDQQPDLCALLLA 416
Query: 115 YGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
+GA V GW P HFAA+ G + L A +DA + G TP +A
Sbjct: 417 HGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLA 468
Score = 44.7 bits (104), Expect = 7e-05
Identities = 37/148 (25%), Positives = 62/148 (41%), Gaps = 10/148 (6%)
Query: 12 QISHKTGCSHISMHSPGGLTTTKMAGPLPRVSDSLFSAM-------ELAKMSDMTKLHQA 64
+I H SH +M + G + T + +++ SA+ A+ S T LH A
Sbjct: 607 EIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLA 666
Query: 65 VAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTS 124
V + V +L+ V W TP H AA+KG ++++L+E GA+ +
Sbjct: 667 VQRSTFLSVINLLEHHANVHARNKVGW---TPAHLAALKGNTAILKVLVEAGAQLDVQDG 723
Query: 125 VGWTPAHFAAEAGHLNILKTLHALHAAI 152
V TP A + I+ L ++
Sbjct: 724 VSCTPLQLALRSRKQGIMSFLEGKEPSV 751
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 70.9 bits (172), Expect = 1e-12
Identities = 63/195 (32%), Positives = 91/195 (46%), Gaps = 15/195 (7%)
Query: 9 RAPQISHKTGCSHISMHSPGGLTTTKMA---GPLPRVSDSLF--SAMELAKMSDMTKLHQ 63
R ++ KTG S I + GLT +A G LP V + L ++ ++ + T LH
Sbjct: 418 RVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 476
Query: 64 AVAAGDYSLVKKILK-KGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLV 122
A AG + K +L+ K + KD D+TPLH AA G +++LL+E A P L
Sbjct: 477 AARAGHTEVAKYLLQNKAKVNAKAKD----DQTPLHCAARIGHTNMVKLLLENNANPNLA 532
Query: 123 TSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAE 182
T+ G TP H AA GH+ + L A+ G TP +A YG+ L + +
Sbjct: 533 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 592
Query: 183 PECQDHRCAAQQKGL 197
H AA + GL
Sbjct: 593 A----HPNAAGKNGL 603
Score = 60.8 bits (146), Expect = 1e-09
Identities = 47/147 (31%), Positives = 69/147 (46%), Gaps = 11/147 (7%)
Query: 55 MSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIE 114
+ +T LH A G + + K +L KG PN + + N TPLH A K + V+ LL++
Sbjct: 369 LDHLTPLHVAAHCGHHRVAKVLLDKG-AKPNSRAL--NGFTPLHIACKKNHVRVMELLLK 425
Query: 115 YGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKAC 174
GA VT G TP H A+ GHL I+K L A+ + + +TP +A G
Sbjct: 426 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 485
Query: 175 VAFL--------EKAEPECQDHRCAAQ 193
+L KA+ + CAA+
Sbjct: 486 AKYLLQNKAKVNAKAKDDQTPLHCAAR 512
Score = 57.8 bits (138), Expect = 9e-09
Identities = 38/110 (34%), Positives = 56/110 (50%), Gaps = 3/110 (2%)
Query: 53 AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLL 112
A + +T LH AV + +VK +L +G + WN TPLH AA + Q+EV R L
Sbjct: 598 AGKNGLTPLHVAVHHNNLDIVKLLLPRG---GSPHSPAWNGYTPLHIAAKQNQVEVARSL 654
Query: 113 IEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTP 162
++YG + G TP H AA+ GH ++ L + A + + G TP
Sbjct: 655 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 704
Score = 57.4 bits (137), Expect = 1e-08
Identities = 43/145 (29%), Positives = 68/145 (46%), Gaps = 5/145 (3%)
Query: 36 AGPLPRVSDSLFSAMEL--AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWND 93
+G L + D L + +++ + + LH A G +V ++L K + +
Sbjct: 55 SGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII---LETTTKKG 111
Query: 94 RTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
T LH AA+ GQ EV+R L+ YGA + G+TP + AA+ HL ++K L A +
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 171
Query: 154 APDFFGDTPKRIAQIYGQKACVAFL 178
G TP +A G + VA L
Sbjct: 172 VATEDGFTPLAVALQQGHENVVAHL 196
Score = 56.6 bits (135), Expect = 2e-08
Identities = 37/133 (27%), Positives = 64/133 (48%), Gaps = 6/133 (4%)
Query: 41 RVSDSLF---SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPL 97
R+S+ L + ++ + ++ +H A V+ +L+ D D+ + TPL
Sbjct: 319 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY---DAEIDDITLDHLTPL 375
Query: 98 HWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDF 157
H AA G V ++L++ GA+P G+TP H A + H+ +++ L A+IDA
Sbjct: 376 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 435
Query: 158 FGDTPKRIAQIYG 170
G TP +A G
Sbjct: 436 SGLTPLHVASFMG 448
Score = 53.5 bits (127), Expect = 2e-07
Identities = 37/110 (33%), Positives = 55/110 (50%), Gaps = 3/110 (2%)
Query: 57 DMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYG 116
D T LH A G ++VK +L+ +PN + TPLH AA +G +E + L+E
Sbjct: 503 DQTPLHCAARIGHTNMVKLLLENN-ANPNLATTAGH--TPLHIAAREGHVETVLALLEKE 559
Query: 117 ARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
A +T G+TP H AA+ G + + + L A +A G TP +A
Sbjct: 560 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 609
Score = 52.0 bits (123), Expect = 5e-07
Identities = 35/120 (29%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGL-CDPNYKDVDWNDRTPLHWAAIKGQM 106
+++ + +T LH A G+ +V+ +L +G + KD + TPLH AA G +
Sbjct: 263 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD----ELTPLHCAARNGHV 318
Query: 107 EVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
+ +L+++GA T G +P H AA+ HL+ ++ L A ID TP +A
Sbjct: 319 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 378
Score = 51.2 bits (121), Expect = 8e-07
Identities = 37/123 (30%), Positives = 57/123 (46%), Gaps = 3/123 (2%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
+T LH A G +V +L K N + + TPLH A +G + V +LI++G
Sbjct: 669 VTPLHLAAQEGHAEMVALLLSK---QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 725
Query: 118 RPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAF 177
T +G+TP H A+ G++ ++K L A ++A G +P A G V
Sbjct: 726 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 785
Query: 178 LEK 180
L K
Sbjct: 786 LLK 788
Score = 50.4 bits (119), Expect = 1e-06
Identities = 36/122 (29%), Positives = 59/122 (48%), Gaps = 9/122 (7%)
Query: 52 LAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDR---TPLHWAAIKGQMEV 108
L S +T LH G + ++K G+ VD R TPLH A+ G +++
Sbjct: 696 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVM------VDATTRMGYTPLHVASHYGNIKL 749
Query: 109 IRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQI 168
++ L+++ A T +G++P H AA+ GH +I+ L A+ + G TP IA+
Sbjct: 750 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 809
Query: 169 YG 170
G
Sbjct: 810 LG 811
Score = 50.1 bits (118), Expect = 2e-06
Identities = 33/120 (27%), Positives = 54/120 (45%), Gaps = 3/120 (2%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A G + + +L++ D + N TPLH A +++++LL+ G
Sbjct: 571 TPLHVAAKYGKVRVAELLLER---DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 627
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
P G+TP H AA+ + + ++L + +A G TP +A G VA L
Sbjct: 628 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 687
Score = 48.9 bits (115), Expect = 4e-06
Identities = 39/137 (28%), Positives = 63/137 (45%), Gaps = 3/137 (2%)
Query: 51 ELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIR 110
++ + T LH A + ++ + +L +G + N TPLH A+ +G + ++R
Sbjct: 233 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGA---SVNFTPQNGITPLHIASRRGNVIMVR 289
Query: 111 LLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYG 170
LL++ GA+ T TP H AA GH+ I + L A I A G +P +A
Sbjct: 290 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 349
Query: 171 QKACVAFLEKAEPECQD 187
CV L + + E D
Sbjct: 350 HLDCVRLLLQYDAEIDD 366
Score = 44.7 bits (104), Expect = 7e-05
Identities = 31/92 (33%), Positives = 46/92 (50%), Gaps = 13/92 (14%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRT-----PLHWAAIKGQMEVIRLLI 113
T LH A G+ LVK +L+ D N +T PLH AA +G +++ LL+
Sbjct: 736 TPLHVASHYGNIKLVKFLLQH--------QADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 787
Query: 114 EYGARPCLVTSVGWTPAHFAAEAGHLNILKTL 145
+ GA P V+S G TP A G++++ L
Sbjct: 788 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 38.5 bits (88), Expect = 0.005
Identities = 30/113 (26%), Positives = 47/113 (41%), Gaps = 8/113 (7%)
Query: 97 LHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPD 156
LH AA +L++ P +++ G+TP H AA +LN+ + L A+++
Sbjct: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 269
Query: 157 FFGDTPKRIAQIYGQKACVAFL--------EKAEPECQDHRCAAQQKGLPLDE 201
G TP IA G V L K + E CAA+ + + E
Sbjct: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 322
Score = 35.8 bits (81), Expect = 0.035
Identities = 26/85 (30%), Positives = 38/85 (44%), Gaps = 3/85 (3%)
Query: 61 LHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPC 120
LH A D +L+ DPN + TPLH AA + V +LL+ GA
Sbjct: 210 LHIAARNDDTRTAAVLLQN---DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 266
Query: 121 LVTSVGWTPAHFAAEAGHLNILKTL 145
G TP H A+ G++ +++ L
Sbjct: 267 FTPQNGITPLHIASRRGNVIMVRLL 291
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 70.9 bits (172), Expect = 1e-12
Identities = 63/195 (32%), Positives = 91/195 (46%), Gaps = 15/195 (7%)
Query: 9 RAPQISHKTGCSHISMHSPGGLTTTKMA---GPLPRVSDSLF--SAMELAKMSDMTKLHQ 63
R ++ KTG S I + GLT +A G LP V + L ++ ++ + T LH
Sbjct: 385 RVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 64 AVAAGDYSLVKKILK-KGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLV 122
A AG + K +L+ K + KD D+TPLH AA G +++LL+E A P L
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKD----DQTPLHCAARIGHTNMVKLLLENNANPNLA 499
Query: 123 TSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAE 182
T+ G TP H AA GH+ + L A+ G TP +A YG+ L + +
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 183 PECQDHRCAAQQKGL 197
H AA + GL
Sbjct: 560 A----HPNAAGKNGL 570
Score = 60.8 bits (146), Expect = 1e-09
Identities = 47/147 (31%), Positives = 69/147 (46%), Gaps = 11/147 (7%)
Query: 55 MSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIE 114
+ +T LH A G + + K +L KG PN + + N TPLH A K + V+ LL++
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKG-AKPNSRAL--NGFTPLHIACKKNHVRVMELLLK 392
Query: 115 YGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKAC 174
GA VT G TP H A+ GHL I+K L A+ + + +TP +A G
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452
Query: 175 VAFL--------EKAEPECQDHRCAAQ 193
+L KA+ + CAA+
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Score = 57.8 bits (138), Expect = 9e-09
Identities = 38/110 (34%), Positives = 56/110 (50%), Gaps = 3/110 (2%)
Query: 53 AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLL 112
A + +T LH AV + +VK +L +G + WN TPLH AA + Q+EV R L
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRG---GSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 113 IEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTP 162
++YG + G TP H AA+ GH ++ L + A + + G TP
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 671
Score = 57.4 bits (137), Expect = 1e-08
Identities = 43/145 (29%), Positives = 68/145 (46%), Gaps = 5/145 (3%)
Query: 36 AGPLPRVSDSLFSAMEL--AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWND 93
+G L + D L + +++ + + LH A G +V ++L K + +
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII---LETTTKKG 78
Query: 94 RTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
T LH AA+ GQ EV+R L+ YGA + G+TP + AA+ HL ++K L A +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 154 APDFFGDTPKRIAQIYGQKACVAFL 178
G TP +A G + VA L
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHL 163
Score = 56.6 bits (135), Expect = 2e-08
Identities = 37/133 (27%), Positives = 64/133 (48%), Gaps = 6/133 (4%)
Query: 41 RVSDSLF---SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPL 97
R+S+ L + ++ + ++ +H A V+ +L+ D D+ + TPL
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY---DAEIDDITLDHLTPL 342
Query: 98 HWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDF 157
H AA G V ++L++ GA+P G+TP H A + H+ +++ L A+IDA
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402
Query: 158 FGDTPKRIAQIYG 170
G TP +A G
Sbjct: 403 SGLTPLHVASFMG 415
Score = 53.5 bits (127), Expect = 2e-07
Identities = 37/110 (33%), Positives = 55/110 (50%), Gaps = 3/110 (2%)
Query: 57 DMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYG 116
D T LH A G ++VK +L+ +PN + TPLH AA +G +E + L+E
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENN-ANPNLATTAGH--TPLHIAAREGHVETVLALLEKE 526
Query: 117 ARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
A +T G+TP H AA+ G + + + L A +A G TP +A
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 52.0 bits (123), Expect = 5e-07
Identities = 35/120 (29%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGL-CDPNYKDVDWNDRTPLHWAAIKGQM 106
+++ + +T LH A G+ +V+ +L +G + KD + TPLH AA G +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD----ELTPLHCAARNGHV 285
Query: 107 EVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
+ +L+++GA T G +P H AA+ HL+ ++ L A ID TP +A
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Score = 51.2 bits (121), Expect = 8e-07
Identities = 37/123 (30%), Positives = 57/123 (46%), Gaps = 3/123 (2%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
+T LH A G +V +L K N + + TPLH A +G + V +LI++G
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSK---QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Query: 118 RPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAF 177
T +G+TP H A+ G++ ++K L A ++A G +P A G V
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 178 LEK 180
L K
Sbjct: 753 LLK 755
Score = 50.4 bits (119), Expect = 1e-06
Identities = 36/122 (29%), Positives = 59/122 (48%), Gaps = 9/122 (7%)
Query: 52 LAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDR---TPLHWAAIKGQMEV 108
L S +T LH G + ++K G+ VD R TPLH A+ G +++
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVM------VDATTRMGYTPLHVASHYGNIKL 716
Query: 109 IRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQI 168
++ L+++ A T +G++P H AA+ GH +I+ L A+ + G TP IA+
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776
Query: 169 YG 170
G
Sbjct: 777 LG 778
Score = 50.1 bits (118), Expect = 2e-06
Identities = 33/120 (27%), Positives = 54/120 (45%), Gaps = 3/120 (2%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A G + + +L++ D + N TPLH A +++++LL+ G
Sbjct: 538 TPLHVAAKYGKVRVAELLLER---DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
P G+TP H AA+ + + ++L + +A G TP +A G VA L
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 48.9 bits (115), Expect = 4e-06
Identities = 39/137 (28%), Positives = 63/137 (45%), Gaps = 3/137 (2%)
Query: 51 ELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIR 110
++ + T LH A + ++ + +L +G + N TPLH A+ +G + ++R
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGA---SVNFTPQNGITPLHIASRRGNVIMVR 256
Query: 111 LLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYG 170
LL++ GA+ T TP H AA GH+ I + L A I A G +P +A
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 171 QKACVAFLEKAEPECQD 187
CV L + + E D
Sbjct: 317 HLDCVRLLLQYDAEIDD 333
Score = 44.7 bits (104), Expect = 7e-05
Identities = 31/92 (33%), Positives = 46/92 (50%), Gaps = 13/92 (14%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRT-----PLHWAAIKGQMEVIRLLI 113
T LH A G+ LVK +L+ D N +T PLH AA +G +++ LL+
Sbjct: 703 TPLHVASHYGNIKLVKFLLQH--------QADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 114 EYGARPCLVTSVGWTPAHFAAEAGHLNILKTL 145
+ GA P V+S G TP A G++++ L
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 38.5 bits (88), Expect = 0.005
Identities = 30/113 (26%), Positives = 47/113 (41%), Gaps = 8/113 (7%)
Query: 97 LHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPD 156
LH AA +L++ P +++ G+TP H AA +LN+ + L A+++
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 157 FFGDTPKRIAQIYGQKACVAFL--------EKAEPECQDHRCAAQQKGLPLDE 201
G TP IA G V L K + E CAA+ + + E
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Score = 35.8 bits (81), Expect = 0.035
Identities = 26/85 (30%), Positives = 38/85 (44%), Gaps = 3/85 (3%)
Query: 61 LHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPC 120
LH A D +L+ DPN + TPLH AA + V +LL+ GA
Sbjct: 177 LHIAARNDDTRTAAVLLQN---DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 121 LVTSVGWTPAHFAAEAGHLNILKTL 145
G TP H A+ G++ +++ L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLL 258
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 70.9 bits (172), Expect = 1e-12
Identities = 63/195 (32%), Positives = 91/195 (46%), Gaps = 15/195 (7%)
Query: 9 RAPQISHKTGCSHISMHSPGGLTTTKMA---GPLPRVSDSLF--SAMELAKMSDMTKLHQ 63
R ++ KTG S I + GLT +A G LP V + L ++ ++ + T LH
Sbjct: 385 RVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 64 AVAAGDYSLVKKILK-KGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLV 122
A AG + K +L+ K + KD D+TPLH AA G +++LL+E A P L
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKD----DQTPLHCAARIGHTNMVKLLLENNANPNLA 499
Query: 123 TSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAE 182
T+ G TP H AA GH+ + L A+ G TP +A YG+ L + +
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 183 PECQDHRCAAQQKGL 197
H AA + GL
Sbjct: 560 A----HPNAAGKNGL 570
Score = 60.8 bits (146), Expect = 1e-09
Identities = 47/147 (31%), Positives = 69/147 (46%), Gaps = 11/147 (7%)
Query: 55 MSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIE 114
+ +T LH A G + + K +L KG PN + + N TPLH A K + V+ LL++
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKG-AKPNSRAL--NGFTPLHIACKKNHVRVMELLLK 392
Query: 115 YGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKAC 174
GA VT G TP H A+ GHL I+K L A+ + + +TP +A G
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452
Query: 175 VAFL--------EKAEPECQDHRCAAQ 193
+L KA+ + CAA+
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Score = 57.8 bits (138), Expect = 9e-09
Identities = 38/110 (34%), Positives = 56/110 (50%), Gaps = 3/110 (2%)
Query: 53 AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLL 112
A + +T LH AV + +VK +L +G + WN TPLH AA + Q+EV R L
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRG---GSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 113 IEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTP 162
++YG + G TP H AA+ GH ++ L + A + + G TP
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 671
Score = 57.4 bits (137), Expect = 1e-08
Identities = 43/145 (29%), Positives = 68/145 (46%), Gaps = 5/145 (3%)
Query: 36 AGPLPRVSDSLFSAMEL--AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWND 93
+G L + D L + +++ + + LH A G +V ++L K + +
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII---LETTTKKG 78
Query: 94 RTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
T LH AA+ GQ EV+R L+ YGA + G+TP + AA+ HL ++K L A +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 154 APDFFGDTPKRIAQIYGQKACVAFL 178
G TP +A G + VA L
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHL 163
Score = 56.6 bits (135), Expect = 2e-08
Identities = 37/133 (27%), Positives = 64/133 (48%), Gaps = 6/133 (4%)
Query: 41 RVSDSLF---SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPL 97
R+S+ L + ++ + ++ +H A V+ +L+ D D+ + TPL
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY---DAEIDDITLDHLTPL 342
Query: 98 HWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDF 157
H AA G V ++L++ GA+P G+TP H A + H+ +++ L A+IDA
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402
Query: 158 FGDTPKRIAQIYG 170
G TP +A G
Sbjct: 403 SGLTPLHVASFMG 415
Score = 53.5 bits (127), Expect = 2e-07
Identities = 37/110 (33%), Positives = 55/110 (50%), Gaps = 3/110 (2%)
Query: 57 DMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYG 116
D T LH A G ++VK +L+ +PN + TPLH AA +G +E + L+E
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENN-ANPNLATTAGH--TPLHIAAREGHVETVLALLEKE 526
Query: 117 ARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
A +T G+TP H AA+ G + + + L A +A G TP +A
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 52.0 bits (123), Expect = 5e-07
Identities = 35/120 (29%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGL-CDPNYKDVDWNDRTPLHWAAIKGQM 106
+++ + +T LH A G+ +V+ +L +G + KD + TPLH AA G +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD----ELTPLHCAARNGHV 285
Query: 107 EVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
+ +L+++GA T G +P H AA+ HL+ ++ L A ID TP +A
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Score = 51.2 bits (121), Expect = 8e-07
Identities = 37/123 (30%), Positives = 57/123 (46%), Gaps = 3/123 (2%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
+T LH A G +V +L K N + + TPLH A +G + V +LI++G
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSK---QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Query: 118 RPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAF 177
T +G+TP H A+ G++ ++K L A ++A G +P A G V
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 178 LEK 180
L K
Sbjct: 753 LLK 755
Score = 50.4 bits (119), Expect = 1e-06
Identities = 36/122 (29%), Positives = 59/122 (48%), Gaps = 9/122 (7%)
Query: 52 LAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDR---TPLHWAAIKGQMEV 108
L S +T LH G + ++K G+ VD R TPLH A+ G +++
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVM------VDATTRMGYTPLHVASHYGNIKL 716
Query: 109 IRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQI 168
++ L+++ A T +G++P H AA+ GH +I+ L A+ + G TP IA+
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776
Query: 169 YG 170
G
Sbjct: 777 LG 778
Score = 50.1 bits (118), Expect = 2e-06
Identities = 33/120 (27%), Positives = 54/120 (45%), Gaps = 3/120 (2%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A G + + +L++ D + N TPLH A +++++LL+ G
Sbjct: 538 TPLHVAAKYGKVRVAELLLER---DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
P G+TP H AA+ + + ++L + +A G TP +A G VA L
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 48.9 bits (115), Expect = 4e-06
Identities = 39/137 (28%), Positives = 63/137 (45%), Gaps = 3/137 (2%)
Query: 51 ELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIR 110
++ + T LH A + ++ + +L +G + N TPLH A+ +G + ++R
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGA---SVNFTPQNGITPLHIASRRGNVIMVR 256
Query: 111 LLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYG 170
LL++ GA+ T TP H AA GH+ I + L A I A G +P +A
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 171 QKACVAFLEKAEPECQD 187
CV L + + E D
Sbjct: 317 HLDCVRLLLQYDAEIDD 333
Score = 44.7 bits (104), Expect = 7e-05
Identities = 31/92 (33%), Positives = 46/92 (50%), Gaps = 13/92 (14%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRT-----PLHWAAIKGQMEVIRLLI 113
T LH A G+ LVK +L+ D N +T PLH AA +G +++ LL+
Sbjct: 703 TPLHVASHYGNIKLVKFLLQH--------QADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 114 EYGARPCLVTSVGWTPAHFAAEAGHLNILKTL 145
+ GA P V+S G TP A G++++ L
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 38.5 bits (88), Expect = 0.005
Identities = 30/113 (26%), Positives = 47/113 (41%), Gaps = 8/113 (7%)
Query: 97 LHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPD 156
LH AA +L++ P +++ G+TP H AA +LN+ + L A+++
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 157 FFGDTPKRIAQIYGQKACVAFL--------EKAEPECQDHRCAAQQKGLPLDE 201
G TP IA G V L K + E CAA+ + + E
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Score = 35.8 bits (81), Expect = 0.035
Identities = 26/85 (30%), Positives = 38/85 (44%), Gaps = 3/85 (3%)
Query: 61 LHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPC 120
LH A D +L+ DPN + TPLH AA + V +LL+ GA
Sbjct: 177 LHIAARNDDTRTAAVLLQN---DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 121 LVTSVGWTPAHFAAEAGHLNILKTL 145
G TP H A+ G++ +++ L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLL 258
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 70.9 bits (172), Expect = 1e-12
Identities = 63/195 (32%), Positives = 91/195 (46%), Gaps = 15/195 (7%)
Query: 9 RAPQISHKTGCSHISMHSPGGLTTTKMA---GPLPRVSDSLF--SAMELAKMSDMTKLHQ 63
R ++ KTG S I + GLT +A G LP V + L ++ ++ + T LH
Sbjct: 385 RVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 64 AVAAGDYSLVKKILK-KGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLV 122
A AG + K +L+ K + KD D+TPLH AA G +++LL+E A P L
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKD----DQTPLHCAARIGHTNMVKLLLENNANPNLA 499
Query: 123 TSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAE 182
T+ G TP H AA GH+ + L A+ G TP +A YG+ L + +
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 183 PECQDHRCAAQQKGL 197
H AA + GL
Sbjct: 560 A----HPNAAGKNGL 570
Score = 60.8 bits (146), Expect = 1e-09
Identities = 47/147 (31%), Positives = 69/147 (46%), Gaps = 11/147 (7%)
Query: 55 MSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIE 114
+ +T LH A G + + K +L KG PN + + N TPLH A K + V+ LL++
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKG-AKPNSRAL--NGFTPLHIACKKNHVRVMELLLK 392
Query: 115 YGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKAC 174
GA VT G TP H A+ GHL I+K L A+ + + +TP +A G
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452
Query: 175 VAFL--------EKAEPECQDHRCAAQ 193
+L KA+ + CAA+
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Score = 57.8 bits (138), Expect = 9e-09
Identities = 38/110 (34%), Positives = 56/110 (50%), Gaps = 3/110 (2%)
Query: 53 AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLL 112
A + +T LH AV + +VK +L +G + WN TPLH AA + Q+EV R L
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRG---GSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 113 IEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTP 162
++YG + G TP H AA+ GH ++ L + A + + G TP
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 671
Score = 57.4 bits (137), Expect = 1e-08
Identities = 43/145 (29%), Positives = 68/145 (46%), Gaps = 5/145 (3%)
Query: 36 AGPLPRVSDSLFSAMEL--AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWND 93
+G L + D L + +++ + + LH A G +V ++L K + +
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII---LETTTKKG 78
Query: 94 RTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
T LH AA+ GQ EV+R L+ YGA + G+TP + AA+ HL ++K L A +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 154 APDFFGDTPKRIAQIYGQKACVAFL 178
G TP +A G + VA L
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHL 163
Score = 56.6 bits (135), Expect = 2e-08
Identities = 37/133 (27%), Positives = 64/133 (48%), Gaps = 6/133 (4%)
Query: 41 RVSDSLF---SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPL 97
R+S+ L + ++ + ++ +H A V+ +L+ D D+ + TPL
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY---DAEIDDITLDHLTPL 342
Query: 98 HWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDF 157
H AA G V ++L++ GA+P G+TP H A + H+ +++ L A+IDA
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402
Query: 158 FGDTPKRIAQIYG 170
G TP +A G
Sbjct: 403 SGLTPLHVASFMG 415
Score = 53.5 bits (127), Expect = 2e-07
Identities = 37/110 (33%), Positives = 55/110 (50%), Gaps = 3/110 (2%)
Query: 57 DMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYG 116
D T LH A G ++VK +L+ +PN + TPLH AA +G +E + L+E
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENN-ANPNLATTAGH--TPLHIAAREGHVETVLALLEKE 526
Query: 117 ARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
A +T G+TP H AA+ G + + + L A +A G TP +A
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 52.0 bits (123), Expect = 5e-07
Identities = 35/120 (29%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGL-CDPNYKDVDWNDRTPLHWAAIKGQM 106
+++ + +T LH A G+ +V+ +L +G + KD + TPLH AA G +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD----ELTPLHCAARNGHV 285
Query: 107 EVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
+ +L+++GA T G +P H AA+ HL+ ++ L A ID TP +A
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Score = 51.2 bits (121), Expect = 8e-07
Identities = 37/123 (30%), Positives = 57/123 (46%), Gaps = 3/123 (2%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
+T LH A G +V +L K N + + TPLH A +G + V +LI++G
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSK---QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Query: 118 RPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAF 177
T +G+TP H A+ G++ ++K L A ++A G +P A G V
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 178 LEK 180
L K
Sbjct: 753 LLK 755
Score = 50.4 bits (119), Expect = 1e-06
Identities = 36/122 (29%), Positives = 59/122 (48%), Gaps = 9/122 (7%)
Query: 52 LAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDR---TPLHWAAIKGQMEV 108
L S +T LH G + ++K G+ VD R TPLH A+ G +++
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVM------VDATTRMGYTPLHVASHYGNIKL 716
Query: 109 IRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQI 168
++ L+++ A T +G++P H AA+ GH +I+ L A+ + G TP IA+
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776
Query: 169 YG 170
G
Sbjct: 777 LG 778
Score = 50.1 bits (118), Expect = 2e-06
Identities = 33/120 (27%), Positives = 54/120 (45%), Gaps = 3/120 (2%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A G + + +L++ D + N TPLH A +++++LL+ G
Sbjct: 538 TPLHVAAKYGKVRVAELLLER---DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
P G+TP H AA+ + + ++L + +A G TP +A G VA L
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 48.9 bits (115), Expect = 4e-06
Identities = 39/137 (28%), Positives = 63/137 (45%), Gaps = 3/137 (2%)
Query: 51 ELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIR 110
++ + T LH A + ++ + +L +G + N TPLH A+ +G + ++R
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGA---SVNFTPQNGITPLHIASRRGNVIMVR 256
Query: 111 LLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYG 170
LL++ GA+ T TP H AA GH+ I + L A I A G +P +A
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 171 QKACVAFLEKAEPECQD 187
CV L + + E D
Sbjct: 317 HLDCVRLLLQYDAEIDD 333
Score = 44.7 bits (104), Expect = 7e-05
Identities = 31/92 (33%), Positives = 46/92 (50%), Gaps = 13/92 (14%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRT-----PLHWAAIKGQMEVIRLLI 113
T LH A G+ LVK +L+ D N +T PLH AA +G +++ LL+
Sbjct: 703 TPLHVASHYGNIKLVKFLLQH--------QADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 114 EYGARPCLVTSVGWTPAHFAAEAGHLNILKTL 145
+ GA P V+S G TP A G++++ L
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 38.5 bits (88), Expect = 0.005
Identities = 30/113 (26%), Positives = 47/113 (41%), Gaps = 8/113 (7%)
Query: 97 LHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPD 156
LH AA +L++ P +++ G+TP H AA +LN+ + L A+++
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 157 FFGDTPKRIAQIYGQKACVAFL--------EKAEPECQDHRCAAQQKGLPLDE 201
G TP IA G V L K + E CAA+ + + E
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Score = 35.8 bits (81), Expect = 0.035
Identities = 26/85 (30%), Positives = 38/85 (44%), Gaps = 3/85 (3%)
Query: 61 LHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPC 120
LH A D +L+ DPN + TPLH AA + V +LL+ GA
Sbjct: 177 LHIAARNDDTRTAAVLLQN---DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 121 LVTSVGWTPAHFAAEAGHLNILKTL 145
G TP H A+ G++ +++ L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLL 258
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 70.9 bits (172), Expect = 1e-12
Identities = 63/195 (32%), Positives = 91/195 (46%), Gaps = 15/195 (7%)
Query: 9 RAPQISHKTGCSHISMHSPGGLTTTKMA---GPLPRVSDSLF--SAMELAKMSDMTKLHQ 63
R ++ KTG S I + GLT +A G LP V + L ++ ++ + T LH
Sbjct: 385 RVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 64 AVAAGDYSLVKKILK-KGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLV 122
A AG + K +L+ K + KD D+TPLH AA G +++LL+E A P L
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKD----DQTPLHCAARIGHTNMVKLLLENNANPNLA 499
Query: 123 TSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAE 182
T+ G TP H AA GH+ + L A+ G TP +A YG+ L + +
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 183 PECQDHRCAAQQKGL 197
H AA + GL
Sbjct: 560 A----HPNAAGKNGL 570
Score = 60.8 bits (146), Expect = 1e-09
Identities = 47/147 (31%), Positives = 69/147 (46%), Gaps = 11/147 (7%)
Query: 55 MSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIE 114
+ +T LH A G + + K +L KG PN + + N TPLH A K + V+ LL++
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKG-AKPNSRAL--NGFTPLHIACKKNHVRVMELLLK 392
Query: 115 YGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKAC 174
GA VT G TP H A+ GHL I+K L A+ + + +TP +A G
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452
Query: 175 VAFL--------EKAEPECQDHRCAAQ 193
+L KA+ + CAA+
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Score = 57.8 bits (138), Expect = 9e-09
Identities = 38/110 (34%), Positives = 56/110 (50%), Gaps = 3/110 (2%)
Query: 53 AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLL 112
A + +T LH AV + +VK +L +G + WN TPLH AA + Q+EV R L
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRG---GSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 113 IEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTP 162
++YG + G TP H AA+ GH ++ L + A + + G TP
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 671
Score = 57.4 bits (137), Expect = 1e-08
Identities = 43/145 (29%), Positives = 68/145 (46%), Gaps = 5/145 (3%)
Query: 36 AGPLPRVSDSLFSAMEL--AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWND 93
+G L + D L + +++ + + LH A G +V ++L K + +
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII---LETTTKKG 78
Query: 94 RTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
T LH AA+ GQ EV+R L+ YGA + G+TP + AA+ HL ++K L A +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 154 APDFFGDTPKRIAQIYGQKACVAFL 178
G TP +A G + VA L
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHL 163
Score = 56.6 bits (135), Expect = 2e-08
Identities = 37/133 (27%), Positives = 64/133 (48%), Gaps = 6/133 (4%)
Query: 41 RVSDSLF---SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPL 97
R+S+ L + ++ + ++ +H A V+ +L+ D D+ + TPL
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY---DAEIDDITLDHLTPL 342
Query: 98 HWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDF 157
H AA G V ++L++ GA+P G+TP H A + H+ +++ L A+IDA
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402
Query: 158 FGDTPKRIAQIYG 170
G TP +A G
Sbjct: 403 SGLTPLHVASFMG 415
Score = 53.5 bits (127), Expect = 2e-07
Identities = 37/110 (33%), Positives = 55/110 (50%), Gaps = 3/110 (2%)
Query: 57 DMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYG 116
D T LH A G ++VK +L+ +PN + TPLH AA +G +E + L+E
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENN-ANPNLATTAGH--TPLHIAAREGHVETVLALLEKE 526
Query: 117 ARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
A +T G+TP H AA+ G + + + L A +A G TP +A
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 52.0 bits (123), Expect = 5e-07
Identities = 35/120 (29%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGL-CDPNYKDVDWNDRTPLHWAAIKGQM 106
+++ + +T LH A G+ +V+ +L +G + KD + TPLH AA G +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD----ELTPLHCAARNGHV 285
Query: 107 EVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
+ +L+++GA T G +P H AA+ HL+ ++ L A ID TP +A
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Score = 51.2 bits (121), Expect = 8e-07
Identities = 37/123 (30%), Positives = 57/123 (46%), Gaps = 3/123 (2%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
+T LH A G +V +L K N + + TPLH A +G + V +LI++G
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSK---QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Query: 118 RPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAF 177
T +G+TP H A+ G++ ++K L A ++A G +P A G V
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 178 LEK 180
L K
Sbjct: 753 LLK 755
Score = 50.4 bits (119), Expect = 1e-06
Identities = 36/122 (29%), Positives = 59/122 (48%), Gaps = 9/122 (7%)
Query: 52 LAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDR---TPLHWAAIKGQMEV 108
L S +T LH G + ++K G+ VD R TPLH A+ G +++
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVM------VDATTRMGYTPLHVASHYGNIKL 716
Query: 109 IRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQI 168
++ L+++ A T +G++P H AA+ GH +I+ L A+ + G TP IA+
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776
Query: 169 YG 170
G
Sbjct: 777 LG 778
Score = 50.1 bits (118), Expect = 2e-06
Identities = 33/120 (27%), Positives = 54/120 (45%), Gaps = 3/120 (2%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A G + + +L++ D + N TPLH A +++++LL+ G
Sbjct: 538 TPLHVAAKYGKVRVAELLLER---DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
P G+TP H AA+ + + ++L + +A G TP +A G VA L
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 48.9 bits (115), Expect = 4e-06
Identities = 39/137 (28%), Positives = 63/137 (45%), Gaps = 3/137 (2%)
Query: 51 ELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIR 110
++ + T LH A + ++ + +L +G + N TPLH A+ +G + ++R
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGA---SVNFTPQNGITPLHIASRRGNVIMVR 256
Query: 111 LLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYG 170
LL++ GA+ T TP H AA GH+ I + L A I A G +P +A
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 171 QKACVAFLEKAEPECQD 187
CV L + + E D
Sbjct: 317 HLDCVRLLLQYDAEIDD 333
Score = 44.7 bits (104), Expect = 7e-05
Identities = 31/92 (33%), Positives = 46/92 (50%), Gaps = 13/92 (14%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRT-----PLHWAAIKGQMEVIRLLI 113
T LH A G+ LVK +L+ D N +T PLH AA +G +++ LL+
Sbjct: 703 TPLHVASHYGNIKLVKFLLQH--------QADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 114 EYGARPCLVTSVGWTPAHFAAEAGHLNILKTL 145
+ GA P V+S G TP A G++++ L
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 38.5 bits (88), Expect = 0.005
Identities = 30/113 (26%), Positives = 47/113 (41%), Gaps = 8/113 (7%)
Query: 97 LHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPD 156
LH AA +L++ P +++ G+TP H AA +LN+ + L A+++
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 157 FFGDTPKRIAQIYGQKACVAFL--------EKAEPECQDHRCAAQQKGLPLDE 201
G TP IA G V L K + E CAA+ + + E
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Score = 35.8 bits (81), Expect = 0.035
Identities = 26/85 (30%), Positives = 38/85 (44%), Gaps = 3/85 (3%)
Query: 61 LHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPC 120
LH A D +L+ DPN + TPLH AA + V +LL+ GA
Sbjct: 177 LHIAARNDDTRTAAVLLQN---DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 121 LVTSVGWTPAHFAAEAGHLNILKTL 145
G TP H A+ G++ +++ L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLL 258
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 68.6 bits (166), Expect = 5e-12
Identities = 46/121 (38%), Positives = 64/121 (52%), Gaps = 3/121 (2%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
+T LH A G Y + K +L K +PN + + N TPLH A K +++V+ LL++YGA
Sbjct: 345 LTALHVAAHCGHYRVTKLLLDKR-ANPNARAL--NGFTPLHIACKKNRIKVMELLVKYGA 401
Query: 118 RPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAF 177
+T G TP H AA GHLNI+ L A+ D + G+T +A GQ V
Sbjct: 402 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 461
Query: 178 L 178
L
Sbjct: 462 L 462
Score = 67.0 bits (162), Expect = 1e-11
Identities = 58/181 (32%), Positives = 85/181 (46%), Gaps = 15/181 (8%)
Query: 57 DMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYG 116
+ T LH A G +V+ +L+ + P+ N TPLH +A +GQ++V +L+E G
Sbjct: 476 EQTPLHIASRLGKTEIVQLLLQH-MAHPDAATT--NGYTPLHISAREGQVDVASVLLEAG 532
Query: 117 ARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIY-GQKACV 175
A L T G+TP H AA+ G L++ K L AA D+ G TP +A Y QK +
Sbjct: 533 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 592
Query: 176 AFLEK-AEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMNKKNKKSRGP 234
LEK A P A+ PL AKK +++++ LN +G
Sbjct: 593 LLLEKGASP-----HATAKNGYTPLHIA-----AKKNQMQIASTLLNYGAETNIVTKQGV 642
Query: 235 T 235
T
Sbjct: 643 T 643
Score = 57.8 bits (138), Expect = 9e-09
Identities = 41/145 (28%), Positives = 69/145 (47%), Gaps = 5/145 (3%)
Query: 36 AGPLPRVSDSLFSAMEL--AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWND 93
AG L +V + L +++ + + LH A G LV+++L +G +
Sbjct: 20 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG---SSVDSATKKG 76
Query: 94 RTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
T LH A++ GQ EV+++L++ GA + G+TP + AA+ H++++K L A
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136
Query: 154 APDFFGDTPKRIAQIYGQKACVAFL 178
G TP +A G VA L
Sbjct: 137 TATEDGFTPLAVALQQGHNQAVAIL 161
Score = 55.1 bits (131), Expect = 6e-08
Identities = 34/98 (34%), Positives = 52/98 (53%), Gaps = 3/98 (3%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQME 107
+A + A + +T LH A + + +L+KG P+ N TPLH AA K QM+
Sbjct: 566 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG-ASPHATAK--NGYTPLHIAAKKNQMQ 622
Query: 108 VIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTL 145
+ L+ YGA +VT G TP H A++ GH +++ L
Sbjct: 623 IASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 660
Score = 54.3 bits (129), Expect = 9e-08
Identities = 36/107 (33%), Positives = 55/107 (51%), Gaps = 5/107 (4%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKG-LCDPNYKDVDWNDRTPLHWAAIKGQM 106
+A++ + +T LH A G+ ++VK +L +G D +D TPLH AA G
Sbjct: 236 AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD----GLTPLHCAARSGHD 291
Query: 107 EVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
+V+ LL+E GA T G +P H AA+ H+ +K L A +D
Sbjct: 292 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338
Score = 53.5 bits (127), Expect = 2e-07
Identities = 43/132 (32%), Positives = 55/132 (41%), Gaps = 5/132 (3%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKIL-KKGLCDPNYKDVDWNDRTPLHWAAIKGQM 106
+A LA T LH A G + K +L ++ D K N TPLH AA
Sbjct: 533 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK----NGLTPLHVAAHYDNQ 588
Query: 107 EVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
+V LL+E GA P G+TP H AA+ + I TL A + G TP +A
Sbjct: 589 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 648
Query: 167 QIYGQKACVAFL 178
G V L
Sbjct: 649 SQEGHTDMVTLL 660
Score = 53.1 bits (126), Expect = 2e-07
Identities = 35/124 (28%), Positives = 59/124 (47%), Gaps = 3/124 (2%)
Query: 55 MSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIE 114
++ T LH A +++ ++K G + + + + TP+H AA G + ++ LL++
Sbjct: 375 LNGFTPLHIACKKNRIKVMELLVKYGA---SIQAITESGLTPIHVAAFMGHLNIVLLLLQ 431
Query: 115 YGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKAC 174
GA P + G T H AA AG + +++ L A +DA TP IA G+
Sbjct: 432 NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI 491
Query: 175 VAFL 178
V L
Sbjct: 492 VQLL 495
Score = 50.8 bits (120), Expect = 1e-06
Identities = 38/131 (29%), Positives = 63/131 (48%), Gaps = 8/131 (6%)
Query: 20 SHISMHSPGGLTTTKMAGPLPRVSDSLFSAMELAKMSDMTKLHQ-----AVAAGDYSLVK 74
++I M + GLT+ +A +V+ + A TKL A G+ +V
Sbjct: 665 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 724
Query: 75 KILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAA 134
+LK+G N N TPLH AA +G +I +L+++GA+P T+ G T A
Sbjct: 725 FLLKQGA---NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 781
Query: 135 EAGHLNILKTL 145
G+++++ TL
Sbjct: 782 RLGYISVVDTL 792
Score = 49.3 bits (116), Expect = 3e-06
Identities = 39/122 (31%), Positives = 54/122 (44%), Gaps = 3/122 (2%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A + +L G + N V TPLH A+ +G +++ LL++ GA
Sbjct: 610 TPLHIAAKKNQMQIASTLLNYG-AETNI--VTKQGVTPLHLASQEGHTDMVTLLLDKGAN 666
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
+ T G T H AA+ +N+ L A DA G TP +A YG V FL
Sbjct: 667 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 726
Query: 179 EK 180
K
Sbjct: 727 LK 728
Score = 48.9 bits (115), Expect = 4e-06
Identities = 38/126 (30%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 56 SDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDR---TPLHWAAIKGQMEVIRLL 112
S T LH A G+ ++ +L +G VD+ R TPLH A+ +G +++LL
Sbjct: 211 SGFTPLHIAAHYGNVNVATLLLNRGAA------VDFTARNGITPLHVASKRGNTNMVKLL 264
Query: 113 IEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQK 172
++ G + T G TP H AA +GH +++ L A + A G +P +A
Sbjct: 265 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 324
Query: 173 ACVAFL 178
CV L
Sbjct: 325 ECVKHL 330
Score = 46.6 bits (109), Expect = 2e-05
Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 3/135 (2%)
Query: 50 MELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVI 109
+ ++ S +T LH A ++ + K G + + + TPL A G ++++
Sbjct: 667 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY---TPLIVACHYGNVKMV 723
Query: 110 RLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIY 169
L++ GA T G+TP H AA+ GH +I+ L A +A G+T IA+
Sbjct: 724 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRL 783
Query: 170 GQKACVAFLEKAEPE 184
G + V L+ E
Sbjct: 784 GYISVVDTLKVVTEE 798
Score = 45.1 bits (105), Expect = 6e-05
Identities = 33/90 (36%), Positives = 41/90 (45%), Gaps = 1/90 (1%)
Query: 95 TPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDA 154
TPLH AA G + V LL+ GA G TP H A++ G+ N++K L IDA
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273
Query: 155 PDFFGDTPKRIAQIYGQKACV-AFLEKAEP 183
G TP A G V LE+ P
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAP 303
Score = 45.1 bits (105), Expect = 6e-05
Identities = 37/122 (30%), Positives = 53/122 (43%), Gaps = 5/122 (4%)
Query: 58 MTKLHQAVAAGDYSLVKKILK-KGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYG 116
++ LH A VK +L+ K D DV + T LH AA G V +LL++
Sbjct: 312 LSPLHMAAQGDHVECVKHLLQHKAPVD----DVTLDYLTALHVAAHCGHYRVTKLLLDKR 367
Query: 117 ARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVA 176
A P G+TP H A + + +++ L A+I A G TP +A G V
Sbjct: 368 ANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 427
Query: 177 FL 178
L
Sbjct: 428 LL 429
Score = 33.1 bits (74), Expect = 0.23
Identities = 20/56 (35%), Positives = 26/56 (46%)
Query: 123 TSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
T G+TP H AA G++N+ L AA+D G TP +A G V L
Sbjct: 209 TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 264
Score = 32.0 bits (71), Expect = 0.50
Identities = 17/55 (30%), Positives = 28/55 (50%)
Query: 126 GWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEK 180
G H AA+ GH+ +++ L +++D+ G+T IA + GQ V L K
Sbjct: 43 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVK 97
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 68.6 bits (166), Expect = 5e-12
Identities = 46/121 (38%), Positives = 64/121 (52%), Gaps = 3/121 (2%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
+T LH A G Y + K +L K +PN + + N TPLH A K +++V+ LL++YGA
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKR-ANPNARAL--NGFTPLHIACKKNRIKVMELLVKYGA 422
Query: 118 RPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAF 177
+T G TP H AA GHLNI+ L A+ D + G+T +A GQ V
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
Query: 178 L 178
L
Sbjct: 483 L 483
Score = 67.0 bits (162), Expect = 1e-11
Identities = 58/181 (32%), Positives = 85/181 (46%), Gaps = 15/181 (8%)
Query: 57 DMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYG 116
+ T LH A G +V+ +L+ + P+ N TPLH +A +GQ++V +L+E G
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQH-MAHPDAATT--NGYTPLHISAREGQVDVASVLLEAG 553
Query: 117 ARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIY-GQKACV 175
A L T G+TP H AA+ G L++ K L AA D+ G TP +A Y QK +
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 613
Query: 176 AFLEK-AEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMNKKNKKSRGP 234
LEK A P A+ PL AKK +++++ LN +G
Sbjct: 614 LLLEKGASP-----HATAKNGYTPLHIA-----AKKNQMQIASTLLNYGAETNIVTKQGV 663
Query: 235 T 235
T
Sbjct: 664 T 664
Score = 57.8 bits (138), Expect = 9e-09
Identities = 41/145 (28%), Positives = 69/145 (47%), Gaps = 5/145 (3%)
Query: 36 AGPLPRVSDSLFSAMEL--AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWND 93
AG L +V + L +++ + + LH A G LV+++L +G +
Sbjct: 41 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG---SSVDSATKKG 97
Query: 94 RTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
T LH A++ GQ EV+++L++ GA + G+TP + AA+ H++++K L A
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 154 APDFFGDTPKRIAQIYGQKACVAFL 178
G TP +A G VA L
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAIL 182
Score = 55.1 bits (131), Expect = 6e-08
Identities = 34/98 (34%), Positives = 52/98 (53%), Gaps = 3/98 (3%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQME 107
+A + A + +T LH A + + +L+KG P+ N TPLH AA K QM+
Sbjct: 587 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG-ASPHATAK--NGYTPLHIAAKKNQMQ 643
Query: 108 VIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTL 145
+ L+ YGA +VT G TP H A++ GH +++ L
Sbjct: 644 IASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 54.3 bits (129), Expect = 9e-08
Identities = 36/107 (33%), Positives = 55/107 (51%), Gaps = 5/107 (4%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKG-LCDPNYKDVDWNDRTPLHWAAIKGQM 106
+A++ + +T LH A G+ ++VK +L +G D +D TPLH AA G
Sbjct: 257 AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD----GLTPLHCAARSGHD 312
Query: 107 EVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
+V+ LL+E GA T G +P H AA+ H+ +K L A +D
Sbjct: 313 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Score = 53.5 bits (127), Expect = 2e-07
Identities = 43/132 (32%), Positives = 55/132 (41%), Gaps = 5/132 (3%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKIL-KKGLCDPNYKDVDWNDRTPLHWAAIKGQM 106
+A LA T LH A G + K +L ++ D K N TPLH AA
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK----NGLTPLHVAAHYDNQ 609
Query: 107 EVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
+V LL+E GA P G+TP H AA+ + I TL A + G TP +A
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669
Query: 167 QIYGQKACVAFL 178
G V L
Sbjct: 670 SQEGHTDMVTLL 681
Score = 53.1 bits (126), Expect = 2e-07
Identities = 35/124 (28%), Positives = 59/124 (47%), Gaps = 3/124 (2%)
Query: 55 MSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIE 114
++ T LH A +++ ++K G + + + + TP+H AA G + ++ LL++
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGA---SIQAITESGLTPIHVAAFMGHLNIVLLLLQ 452
Query: 115 YGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKAC 174
GA P + G T H AA AG + +++ L A +DA TP IA G+
Sbjct: 453 NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI 512
Query: 175 VAFL 178
V L
Sbjct: 513 VQLL 516
Score = 50.8 bits (120), Expect = 1e-06
Identities = 38/131 (29%), Positives = 63/131 (48%), Gaps = 8/131 (6%)
Query: 20 SHISMHSPGGLTTTKMAGPLPRVSDSLFSAMELAKMSDMTKLHQ-----AVAAGDYSLVK 74
++I M + GLT+ +A +V+ + A TKL A G+ +V
Sbjct: 686 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 745
Query: 75 KILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAA 134
+LK+G N N TPLH AA +G +I +L+++GA+P T+ G T A
Sbjct: 746 FLLKQGA---NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Query: 135 EAGHLNILKTL 145
G+++++ TL
Sbjct: 803 RLGYISVVDTL 813
Score = 49.3 bits (116), Expect = 3e-06
Identities = 39/122 (31%), Positives = 54/122 (44%), Gaps = 3/122 (2%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A + +L G + N V TPLH A+ +G +++ LL++ GA
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYG-AETNI--VTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
+ T G T H AA+ +N+ L A DA G TP +A YG V FL
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 179 EK 180
K
Sbjct: 748 LK 749
Score = 48.9 bits (115), Expect = 4e-06
Identities = 38/126 (30%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 56 SDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDR---TPLHWAAIKGQMEVIRLL 112
S T LH A G+ ++ +L +G VD+ R TPLH A+ +G +++LL
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAA------VDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 113 IEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQK 172
++ G + T G TP H AA +GH +++ L A + A G +P +A
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345
Query: 173 ACVAFL 178
CV L
Sbjct: 346 ECVKHL 351
Score = 46.6 bits (109), Expect = 2e-05
Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 3/135 (2%)
Query: 50 MELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVI 109
+ ++ S +T LH A ++ + K G + + + TPL A G ++++
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY---TPLIVACHYGNVKMV 744
Query: 110 RLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIY 169
L++ GA T G+TP H AA+ GH +I+ L A +A G+T IA+
Sbjct: 745 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRL 804
Query: 170 GQKACVAFLEKAEPE 184
G + V L+ E
Sbjct: 805 GYISVVDTLKVVTEE 819
Score = 45.1 bits (105), Expect = 6e-05
Identities = 33/90 (36%), Positives = 41/90 (45%), Gaps = 1/90 (1%)
Query: 95 TPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDA 154
TPLH AA G + V LL+ GA G TP H A++ G+ N++K L IDA
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 155 PDFFGDTPKRIAQIYGQKACV-AFLEKAEP 183
G TP A G V LE+ P
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Score = 45.1 bits (105), Expect = 6e-05
Identities = 37/122 (30%), Positives = 53/122 (43%), Gaps = 5/122 (4%)
Query: 58 MTKLHQAVAAGDYSLVKKILK-KGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYG 116
++ LH A VK +L+ K D DV + T LH AA G V +LL++
Sbjct: 333 LSPLHMAAQGDHVECVKHLLQHKAPVD----DVTLDYLTALHVAAHCGHYRVTKLLLDKR 388
Query: 117 ARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVA 176
A P G+TP H A + + +++ L A+I A G TP +A G V
Sbjct: 389 ANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 448
Query: 177 FL 178
L
Sbjct: 449 LL 450
Score = 33.1 bits (74), Expect = 0.23
Identities = 20/56 (35%), Positives = 26/56 (46%)
Query: 123 TSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
T G+TP H AA G++N+ L AA+D G TP +A G V L
Sbjct: 230 TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Score = 32.0 bits (71), Expect = 0.50
Identities = 17/55 (30%), Positives = 28/55 (50%)
Query: 126 GWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEK 180
G H AA+ GH+ +++ L +++D+ G+T IA + GQ V L K
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVK 118
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 68.6 bits (166), Expect = 5e-12
Identities = 46/121 (38%), Positives = 64/121 (52%), Gaps = 3/121 (2%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
+T LH A G Y + K +L K +PN + + N TPLH A K +++V+ LL++YGA
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKR-ANPNARAL--NGFTPLHIACKKNRIKVMELLVKYGA 422
Query: 118 RPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAF 177
+T G TP H AA GHLNI+ L A+ D + G+T +A GQ V
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
Query: 178 L 178
L
Sbjct: 483 L 483
Score = 67.0 bits (162), Expect = 1e-11
Identities = 58/181 (32%), Positives = 85/181 (46%), Gaps = 15/181 (8%)
Query: 57 DMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYG 116
+ T LH A G +V+ +L+ + P+ N TPLH +A +GQ++V +L+E G
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQH-MAHPDAATT--NGYTPLHISAREGQVDVASVLLEAG 553
Query: 117 ARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIY-GQKACV 175
A L T G+TP H AA+ G L++ K L AA D+ G TP +A Y QK +
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 613
Query: 176 AFLEK-AEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMNKKNKKSRGP 234
LEK A P A+ PL AKK +++++ LN +G
Sbjct: 614 LLLEKGASP-----HATAKNGYTPLHIA-----AKKNQMQIASTLLNYGAETNIVTKQGV 663
Query: 235 T 235
T
Sbjct: 664 T 664
Score = 57.8 bits (138), Expect = 9e-09
Identities = 41/145 (28%), Positives = 69/145 (47%), Gaps = 5/145 (3%)
Query: 36 AGPLPRVSDSLFSAMEL--AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWND 93
AG L +V + L +++ + + LH A G LV+++L +G +
Sbjct: 41 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG---SSVDSATKKG 97
Query: 94 RTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
T LH A++ GQ EV+++L++ GA + G+TP + AA+ H++++K L A
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 154 APDFFGDTPKRIAQIYGQKACVAFL 178
G TP +A G VA L
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAIL 182
Score = 55.1 bits (131), Expect = 6e-08
Identities = 34/98 (34%), Positives = 52/98 (53%), Gaps = 3/98 (3%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQME 107
+A + A + +T LH A + + +L+KG P+ N TPLH AA K QM+
Sbjct: 587 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG-ASPHATAK--NGYTPLHIAAKKNQMQ 643
Query: 108 VIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTL 145
+ L+ YGA +VT G TP H A++ GH +++ L
Sbjct: 644 IASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 54.3 bits (129), Expect = 9e-08
Identities = 36/107 (33%), Positives = 55/107 (51%), Gaps = 5/107 (4%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKG-LCDPNYKDVDWNDRTPLHWAAIKGQM 106
+A++ + +T LH A G+ ++VK +L +G D +D TPLH AA G
Sbjct: 257 AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD----GLTPLHCAARSGHD 312
Query: 107 EVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
+V+ LL+E GA T G +P H AA+ H+ +K L A +D
Sbjct: 313 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Score = 53.5 bits (127), Expect = 2e-07
Identities = 43/132 (32%), Positives = 55/132 (41%), Gaps = 5/132 (3%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKIL-KKGLCDPNYKDVDWNDRTPLHWAAIKGQM 106
+A LA T LH A G + K +L ++ D K N TPLH AA
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK----NGLTPLHVAAHYDNQ 609
Query: 107 EVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
+V LL+E GA P G+TP H AA+ + I TL A + G TP +A
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669
Query: 167 QIYGQKACVAFL 178
G V L
Sbjct: 670 SQEGHTDMVTLL 681
Score = 53.1 bits (126), Expect = 2e-07
Identities = 35/124 (28%), Positives = 59/124 (47%), Gaps = 3/124 (2%)
Query: 55 MSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIE 114
++ T LH A +++ ++K G + + + + TP+H AA G + ++ LL++
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGA---SIQAITESGLTPIHVAAFMGHLNIVLLLLQ 452
Query: 115 YGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKAC 174
GA P + G T H AA AG + +++ L A +DA TP IA G+
Sbjct: 453 NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI 512
Query: 175 VAFL 178
V L
Sbjct: 513 VQLL 516
Score = 50.8 bits (120), Expect = 1e-06
Identities = 38/131 (29%), Positives = 63/131 (48%), Gaps = 8/131 (6%)
Query: 20 SHISMHSPGGLTTTKMAGPLPRVSDSLFSAMELAKMSDMTKLHQ-----AVAAGDYSLVK 74
++I M + GLT+ +A +V+ + A TKL A G+ +V
Sbjct: 686 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 745
Query: 75 KILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAA 134
+LK+G N N TPLH AA +G +I +L+++GA+P T+ G T A
Sbjct: 746 FLLKQGA---NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Query: 135 EAGHLNILKTL 145
G+++++ TL
Sbjct: 803 RLGYISVVDTL 813
Score = 49.3 bits (116), Expect = 3e-06
Identities = 39/122 (31%), Positives = 54/122 (44%), Gaps = 3/122 (2%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A + +L G + N V TPLH A+ +G +++ LL++ GA
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYG-AETNI--VTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
+ T G T H AA+ +N+ L A DA G TP +A YG V FL
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 179 EK 180
K
Sbjct: 748 LK 749
Score = 48.9 bits (115), Expect = 4e-06
Identities = 38/126 (30%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 56 SDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDR---TPLHWAAIKGQMEVIRLL 112
S T LH A G+ ++ +L +G VD+ R TPLH A+ +G +++LL
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAA------VDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 113 IEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQK 172
++ G + T G TP H AA +GH +++ L A + A G +P +A
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345
Query: 173 ACVAFL 178
CV L
Sbjct: 346 ECVKHL 351
Score = 46.6 bits (109), Expect = 2e-05
Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 3/135 (2%)
Query: 50 MELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVI 109
+ ++ S +T LH A ++ + K G + + + TPL A G ++++
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY---TPLIVACHYGNVKMV 744
Query: 110 RLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIY 169
L++ GA T G+TP H AA+ GH +I+ L A +A G+T IA+
Sbjct: 745 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRL 804
Query: 170 GQKACVAFLEKAEPE 184
G + V L+ E
Sbjct: 805 GYISVVDTLKVVTEE 819
Score = 45.1 bits (105), Expect = 6e-05
Identities = 33/90 (36%), Positives = 41/90 (45%), Gaps = 1/90 (1%)
Query: 95 TPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDA 154
TPLH AA G + V LL+ GA G TP H A++ G+ N++K L IDA
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 155 PDFFGDTPKRIAQIYGQKACV-AFLEKAEP 183
G TP A G V LE+ P
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Score = 45.1 bits (105), Expect = 6e-05
Identities = 37/122 (30%), Positives = 53/122 (43%), Gaps = 5/122 (4%)
Query: 58 MTKLHQAVAAGDYSLVKKILK-KGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYG 116
++ LH A VK +L+ K D DV + T LH AA G V +LL++
Sbjct: 333 LSPLHMAAQGDHVECVKHLLQHKAPVD----DVTLDYLTALHVAAHCGHYRVTKLLLDKR 388
Query: 117 ARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVA 176
A P G+TP H A + + +++ L A+I A G TP +A G V
Sbjct: 389 ANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 448
Query: 177 FL 178
L
Sbjct: 449 LL 450
Score = 33.1 bits (74), Expect = 0.23
Identities = 20/56 (35%), Positives = 26/56 (46%)
Query: 123 TSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
T G+TP H AA G++N+ L AA+D G TP +A G V L
Sbjct: 230 TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Score = 32.0 bits (71), Expect = 0.50
Identities = 17/55 (30%), Positives = 28/55 (50%)
Query: 126 GWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEK 180
G H AA+ GH+ +++ L +++D+ G+T IA + GQ V L K
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVK 118
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 67.8 bits (164), Expect = 8e-12
Identities = 45/121 (37%), Positives = 65/121 (53%), Gaps = 3/121 (2%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
+T LH A G Y + K +L K +PN K + N TPLH A K +++V+ LL+++GA
Sbjct: 368 LTALHVAAHCGHYKVAKVLLDKK-ANPNAKAL--NGFTPLHIACKKNRIKVMELLLKHGA 424
Query: 118 RPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAF 177
VT G TP H AA GH+NI+ L A+ + + G+T +A GQ V +
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
Query: 178 L 178
L
Sbjct: 485 L 485
Score = 62.8 bits (151), Expect = 3e-10
Identities = 42/132 (31%), Positives = 66/132 (50%), Gaps = 4/132 (3%)
Query: 50 MELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVI 109
+E D T LH + G +V+++L++G PN + TPLH +A +G +V
Sbjct: 492 VEAKAKDDQTPLHISARLGKADIVQQLLQQG-ASPNAATT--SGYTPLHLSAREGHEDVA 548
Query: 110 RLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIY 169
L+++GA + T G+TP H AA+ G L + L A+ DA G TP +A Y
Sbjct: 549 AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHY 608
Query: 170 -GQKACVAFLEK 180
QK + L++
Sbjct: 609 DNQKVALLLLDQ 620
Score = 61.2 bits (147), Expect = 8e-10
Identities = 36/114 (31%), Positives = 61/114 (53%), Gaps = 5/114 (4%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGL-CDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
T LH A +G +V+ +++ G + KD D+TPLH +A G+ ++++ L++ GA
Sbjct: 468 TALHMAARSGQAEVVRYLVQDGAQVEAKAKD----DQTPLHISARLGKADIVQQLLQQGA 523
Query: 118 RPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQ 171
P T+ G+TP H +A GH ++ L A++ G TP +A YG+
Sbjct: 524 SPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGK 577
Score = 56.2 bits (134), Expect = 2e-08
Identities = 39/131 (29%), Positives = 64/131 (48%), Gaps = 3/131 (2%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQME 107
++++ S +T +H A G ++V +++ G PN +V T LH AA GQ E
Sbjct: 424 ASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG-ASPNTTNV--RGETALHMAARSGQAE 480
Query: 108 VIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQ 167
V+R L++ GA+ TP H +A G +I++ L A+ +A G TP ++
Sbjct: 481 VVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSA 540
Query: 168 IYGQKACVAFL 178
G + AFL
Sbjct: 541 REGHEDVAAFL 551
Score = 55.5 bits (132), Expect = 4e-08
Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 3/116 (2%)
Query: 51 ELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIR 110
+ A S +T LH A + + +L +G P+ N TPLH AA K QM++
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQG-ASPHAAAK--NGYTPLHIAAKKNQMDIAT 648
Query: 111 LLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
L+EYGA VT G H AA+ GH++++ L +A ++ + G TP +A
Sbjct: 649 TLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLA 704
Score = 54.3 bits (129), Expect = 9e-08
Identities = 39/145 (26%), Positives = 68/145 (46%), Gaps = 5/145 (3%)
Query: 36 AGPLPRVSDSLFSAMEL--AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWND 93
AG L + D + + +++ + + LH A G +V ++L++ + N
Sbjct: 51 AGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR---EANVDAATKKG 107
Query: 94 RTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
T LH A++ GQ EV+++L+ GA + G+TP + AA+ HL ++K L A+
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
Query: 154 APDFFGDTPKRIAQIYGQKACVAFL 178
G TP +A G V+ L
Sbjct: 168 LATEDGFTPLAVALQQGHDQVVSLL 192
Score = 52.0 bits (123), Expect = 5e-07
Identities = 32/107 (29%), Positives = 54/107 (50%), Gaps = 5/107 (4%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGL-CDPNYKDVDWNDRTPLHWAAIKGQM 106
+A++ +D+T LH A G+ ++VK +L +G D +D TPLH A G
Sbjct: 259 AAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD----GLTPLHCGARSGHE 314
Query: 107 EVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
+V+ +L++ A T G +P H A + HLN ++ L + +D
Sbjct: 315 QVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD 361
Score = 49.7 bits (117), Expect = 2e-06
Identities = 38/131 (29%), Positives = 61/131 (46%), Gaps = 9/131 (6%)
Query: 51 ELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDW---NDRTPLHWAAIKGQME 107
++ S T LH A G+ ++ +L + VD+ ND TPLH A+ +G
Sbjct: 229 DVESKSGFTPLHIAAHYGNINVATLLLNRAAA------VDFTARNDITPLHVASKRGNAN 282
Query: 108 VIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQ 167
+++LL++ GA+ T G TP H A +GH +++ L A I + G +P +A
Sbjct: 283 MVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMAT 342
Query: 168 IYGQKACVAFL 178
CV L
Sbjct: 343 QGDHLNCVQLL 353
Score = 47.8 bits (112), Expect = 9e-06
Identities = 33/130 (25%), Positives = 63/130 (48%), Gaps = 3/130 (2%)
Query: 50 MELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVI 109
+ L+ S +T LH A ++ + ++ +G + + TPLH G ++++
Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY---TPLHVGCHYGNIKIV 746
Query: 110 RLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIY 169
L+++ A+ T G+TP H AA+ GH +I+ L +A+ + G+T IA+
Sbjct: 747 NFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRL 806
Query: 170 GQKACVAFLE 179
G + V L+
Sbjct: 807 GYISVVDTLK 816
Score = 47.4 bits (111), Expect = 1e-05
Identities = 37/126 (29%), Positives = 54/126 (42%), Gaps = 3/126 (2%)
Query: 53 AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLL 112
A + T LH A + +L+ G D N V +H AA +G ++++ LL
Sbjct: 627 AAKNGYTPLHIAAKKNQMDIATTLLEYG-ADANA--VTRQGIASVHLAAQEGHVDMVSLL 683
Query: 113 IEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQK 172
+ A L G TP H AA+ +N+ + L A +DA G TP + YG
Sbjct: 684 LGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNI 743
Query: 173 ACVAFL 178
V FL
Sbjct: 744 KIVNFL 749
Score = 42.4 bits (98), Expect = 4e-04
Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 3/121 (2%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
++ LH A + V+ +L+ + DV + T LH AA G +V ++L++ A
Sbjct: 335 LSPLHMATQGDHLNCVQLLLQHNV---PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391
Query: 118 RPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAF 177
P G+TP H A + + +++ L A+I A G TP +A G V+
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQ 451
Query: 178 L 178
L
Sbjct: 452 L 452
Score = 39.7 bits (91), Expect = 0.002
Identities = 43/168 (25%), Positives = 65/168 (38%), Gaps = 14/168 (8%)
Query: 17 TGCSHISMHSPGGLTTTKMAGPLPRVSDSLF-----SAMELAKMSDMTKLHQAVAAGDYS 71
T ++++ S G T MA + F ++ LA T L A+ G
Sbjct: 128 TNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQ 187
Query: 72 LVKKILKKGLCDPNYKDVDWNDRTP-LHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPA 130
+V +L+ D R P LH AA K + LL++ + + G+TP
Sbjct: 188 VVSLLLEN--------DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPL 239
Query: 131 HFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
H AA G++N+ L AA+D TP +A G V L
Sbjct: 240 HIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLL 287
Score = 39.7 bits (91), Expect = 0.002
Identities = 35/114 (30%), Positives = 46/114 (40%), Gaps = 3/114 (2%)
Query: 53 AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLL 112
A S T LH + G + +L G + TPLH AA G++EV LL
Sbjct: 528 ATTSGYTPLHLSAREGHEDVAAFLLDHGA---SLSITTKKGFTPLHVAAKYGKLEVANLL 584
Query: 113 IEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
++ A P G TP H AA + + L A+ A G TP IA
Sbjct: 585 LQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638
Score = 33.5 bits (75), Expect = 0.17
Identities = 23/79 (29%), Positives = 34/79 (43%)
Query: 100 AAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFG 159
AA G +E I+ G + G H A++ GH+ ++ L A +DA G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 160 DTPKRIAQIYGQKACVAFL 178
+T IA + GQ V L
Sbjct: 108 NTALHIASLAGQAEVVKVL 126
>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
Length = 777
Score = 65.1 bits (157), Expect = 5e-11
Identities = 58/181 (32%), Positives = 85/181 (46%), Gaps = 18/181 (9%)
Query: 26 SPGGLTTTKMAGPLPRVSDSLFSAMELAKMS------DMTKLHQAVAAGDYSLVKKILKK 79
SPG +T + RV S + L M+ T LH A GD V+ +L+
Sbjct: 391 SPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQN 450
Query: 80 GLCDPNYKD-VDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGW---TPAHFAAE 135
G DPN KD W TPLH A G ++V+ LL+++ A LV + G+ +P H AA+
Sbjct: 451 G-SDPNVKDHAGW---TPLHEACNHGHLKVVELLLQHKA---LVNTTGYQNDSPLHDAAK 503
Query: 136 AGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQK 195
GH++I+K L + A+ +A + FG P K+ + EK E H C+
Sbjct: 504 NGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASH-CSVMNT 562
Query: 196 G 196
G
Sbjct: 563 G 563
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 62.8 bits (151), Expect = 3e-10
Identities = 52/175 (29%), Positives = 84/175 (48%), Gaps = 7/175 (4%)
Query: 43 SDSLFSAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAI 102
+DS + +++ LH A + G + +V+ +L+ G DPN ++ + TPL A
Sbjct: 65 ADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAG-ADPNATTLE--ETTPLFLAVE 121
Query: 103 KGQMEVIRLLIEYGARPCLVTSV-GWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDT 161
GQ++V+RLL+++GA S+ GW H A+ + I+K L A + D FG T
Sbjct: 122 NGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGIT 181
Query: 162 PKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELS 216
P +A YG+ ++ L + C A K PL ++ K EL LS
Sbjct: 182 PLFVAAQYGKLESLSILISSGANV---NCQALDKATPLFIAAQEGHTKCVELLLS 233
Score = 37.7 bits (86), Expect = 0.009
Identities = 33/114 (28%), Positives = 51/114 (44%), Gaps = 12/114 (10%)
Query: 64 AVAAGDYSLVKKILKKGLCDPNYKDVDWNDRT---PLHWAAIKGQMEVIRLLIEYGARPC 120
A G+ +++K+LKKG + VD D P+H AA +E +++LI +
Sbjct: 17 AAREGNVKVLRKLLKKG------RSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSEN 70
Query: 121 LV---TSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQ 171
+ T G+ H AA GH I++ L A +A TP +A GQ
Sbjct: 71 YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQ 124
Score = 31.2 bits (69), Expect = 0.86
Identities = 25/87 (28%), Positives = 39/87 (44%), Gaps = 1/87 (1%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T L A G V+ +L G DP+ + + + P+H AA G +++ LLI R
Sbjct: 214 TPLFIAAQEGHTKCVELLLSSG-ADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNR 272
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTL 145
C +P + A GH + L+ L
Sbjct: 273 ACDTGLNKVSPVYSAVFGGHEDCLEIL 299
>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 62.0 bits (149), Expect = 5e-10
Identities = 41/114 (35%), Positives = 59/114 (51%), Gaps = 3/114 (2%)
Query: 54 KMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLI 113
K D A ++GD V K+L +G D NY +VD T LH A I +++++ L+
Sbjct: 37 KFDDGAVFLAACSSGDTDEVLKLLHRG-ADINYANVD--GLTALHQACIDDNVDMVKFLV 93
Query: 114 EYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQ 167
E GA + GW P H AA G+L+I + L A + A + GDTP IA+
Sbjct: 94 ENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 147
Score = 43.9 bits (102), Expect = 1e-04
Identities = 50/162 (30%), Positives = 75/162 (46%), Gaps = 10/162 (6%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVD-WNDRTPLHWAAIKGQMEVIRLLIEYGA 117
T LH A A G Y+ V K+L + D N KD D W TPLH AA G+ E R+L++
Sbjct: 201 TALHVAAAKG-YTEVLKLLIQAGYDVNIKDYDGW---TPLHAAAHWGKEEACRILVDNLC 256
Query: 118 RPCLVTSVGWTPAHFAAE--AGHLNIL-KTLHALHAAIDAPDFFGDTPKRIAQIYGQKAC 174
+V VG T A E G+L L K + LH+ + D + A + ++
Sbjct: 257 DMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHS--EKRDKKSPLIESTANMDNNQSQ 314
Query: 175 VAFLEKAEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELS 216
F K + + A++ + L ++ DE+ + KK E S
Sbjct: 315 KTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCS 356
Score = 41.2 bits (95), Expect = 8e-04
Identities = 29/91 (31%), Positives = 41/91 (45%), Gaps = 3/91 (3%)
Query: 53 AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLL 112
A + +T LHQA + +VK +++ G N D PLH AA G +++ L
Sbjct: 69 ANVDGLTALHQACIDDNVDMVKFLVENGA---NINQPDNEGWIPLHAAASCGYLDIAEFL 125
Query: 113 IEYGARPCLVTSVGWTPAHFAAEAGHLNILK 143
I GA V S G TP A E +L+
Sbjct: 126 IGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ 156
Score = 40.0 bits (92), Expect = 0.002
Identities = 38/138 (27%), Positives = 62/138 (44%), Gaps = 18/138 (13%)
Query: 95 TPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDA 154
T LH AA KG EV++LLI+ G + GWTP H AA G + L ++
Sbjct: 201 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 260
Query: 155 PDFFGDTPKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKGLPLDERDEDWDAKKRELE 214
+ G T +A + + +LE+ + +Q L ++RD KK L
Sbjct: 261 VNKVGQTAFDVA----DEDILGYLEELQ---------KKQNLLHSEKRD-----KKSPLI 302
Query: 215 LSLPSLNQNMNKKNKKSR 232
S +++ N ++K K++
Sbjct: 303 ESTANMDNNQSQKTFKNK 320
Score = 28.9 bits (63), Expect = 4.3
Identities = 30/107 (28%), Positives = 45/107 (42%), Gaps = 7/107 (6%)
Query: 126 GWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYG-QKACVAFLEKAEPE 184
G T H AA G+ +LK L ++ D+ G TP A +G ++AC ++
Sbjct: 199 GGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNL--- 255
Query: 185 CQDHRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMNKKNKKS 231
C D + D DED EL+ L+ K++KKS
Sbjct: 256 C-DMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHS--EKRDKKS 299
>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 62.0 bits (149), Expect = 5e-10
Identities = 41/114 (35%), Positives = 59/114 (51%), Gaps = 3/114 (2%)
Query: 54 KMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLI 113
K D A ++GD V K+L +G D NY +VD T LH A I +++++ L+
Sbjct: 37 KFDDGAVFLAACSSGDTDEVLKLLHRG-ADINYANVD--GLTALHQACIDDNVDMVKFLV 93
Query: 114 EYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQ 167
E GA + GW P H AA G+L+I + L A + A + GDTP IA+
Sbjct: 94 ENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 147
Score = 43.9 bits (102), Expect = 1e-04
Identities = 50/162 (30%), Positives = 75/162 (46%), Gaps = 10/162 (6%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVD-WNDRTPLHWAAIKGQMEVIRLLIEYGA 117
T LH A A G Y+ V K+L + D N KD D W TPLH AA G+ E R+L++
Sbjct: 201 TALHVAAAKG-YTEVLKLLIQAGYDVNIKDYDGW---TPLHAAAHWGKEEACRILVDNLC 256
Query: 118 RPCLVTSVGWTPAHFAAE--AGHLNIL-KTLHALHAAIDAPDFFGDTPKRIAQIYGQKAC 174
+V VG T A E G+L L K + LH+ + D + A + ++
Sbjct: 257 DMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHS--EKRDKKSPLIESTANMDNNQSQ 314
Query: 175 VAFLEKAEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELS 216
F K + + A++ + L ++ DE+ + KK E S
Sbjct: 315 KTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCS 356
Score = 41.2 bits (95), Expect = 8e-04
Identities = 29/91 (31%), Positives = 41/91 (45%), Gaps = 3/91 (3%)
Query: 53 AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLL 112
A + +T LHQA + +VK +++ G N D PLH AA G +++ L
Sbjct: 69 ANVDGLTALHQACIDDNVDMVKFLVENGA---NINQPDNEGWIPLHAAASCGYLDIAEFL 125
Query: 113 IEYGARPCLVTSVGWTPAHFAAEAGHLNILK 143
I GA V S G TP A E +L+
Sbjct: 126 IGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ 156
Score = 40.0 bits (92), Expect = 0.002
Identities = 38/138 (27%), Positives = 62/138 (44%), Gaps = 18/138 (13%)
Query: 95 TPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDA 154
T LH AA KG EV++LLI+ G + GWTP H AA G + L ++
Sbjct: 201 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 260
Query: 155 PDFFGDTPKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKGLPLDERDEDWDAKKRELE 214
+ G T +A + + +LE+ + +Q L ++RD KK L
Sbjct: 261 VNKVGQTAFDVA----DEDILGYLEELQ---------KKQNLLHSEKRD-----KKSPLI 302
Query: 215 LSLPSLNQNMNKKNKKSR 232
S +++ N ++K K++
Sbjct: 303 ESTANMDNNQSQKTFKNK 320
Score = 28.9 bits (63), Expect = 4.3
Identities = 30/107 (28%), Positives = 45/107 (42%), Gaps = 7/107 (6%)
Query: 126 GWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYG-QKACVAFLEKAEPE 184
G T H AA G+ +LK L ++ D+ G TP A +G ++AC ++
Sbjct: 199 GGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNL--- 255
Query: 185 CQDHRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMNKKNKKS 231
C D + D DED EL+ L+ K++KKS
Sbjct: 256 C-DMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHS--EKRDKKS 299
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 62.0 bits (149), Expect = 5e-10
Identities = 38/109 (34%), Positives = 56/109 (51%), Gaps = 4/109 (3%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A GD S + +L+K + + +VD+ RTP+H A GQ ++R+L+ G
Sbjct: 506 TALHFAAQNGDESSTRLLLEK---NASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVD 562
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTL-HALHAAIDAPDFFGDTPKRIA 166
L W P H+AA GHL I+K L +++A G TP +A
Sbjct: 563 VSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 611
Score = 51.2 bits (121), Expect = 8e-07
Identities = 40/129 (31%), Positives = 59/129 (45%), Gaps = 3/129 (2%)
Query: 50 MELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVI 109
++LA S + LH AV AG K +L +PN + TPLH A + V+
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNN-ANPNLSNR--RGSTPLHMAVERRVRGVV 487
Query: 110 RLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIY 169
LL+ WT HFAA+ G + + L +A+++ DF G TP +A +
Sbjct: 488 ELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQH 547
Query: 170 GQKACVAFL 178
GQ+ V L
Sbjct: 548 GQENIVRIL 556
Score = 51.2 bits (121), Expect = 8e-07
Identities = 46/155 (29%), Positives = 63/155 (40%), Gaps = 9/155 (5%)
Query: 28 GGLTTTKMAGPLPRVSDSLFSAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYK 87
G L K+ P VS + + T LH A G Y + + ++ LC +
Sbjct: 581 GHLPIVKLLAKQPGVS------VNAQTLDGRTPLHLAAQRGHYRVARILID--LCS-DVN 631
Query: 88 DVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHA 147
+TPLH AA G RLL+ GA +TS G+T H AA GHL +K L
Sbjct: 632 VCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVE 691
Query: 148 LHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAE 182
A + A T +A +G V L A+
Sbjct: 692 EKADVLARGPLNQTALHLAAAHGHSEVVEELVSAD 726
>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
Length = 300
Score = 61.2 bits (147), Expect = 8e-10
Identities = 40/128 (31%), Positives = 67/128 (52%), Gaps = 8/128 (6%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
+ +L + A D V+++L+ G DP D RT LH+A+ G ++++LL+++GA
Sbjct: 111 LKRLRDSANANDVETVQQLLEDG-ADPCAADD--KGRTALHFASCNGNDQIVQLLLDHGA 167
Query: 118 RPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAF 177
P +G TP H AA H+ ++ TL A +DA D G TP +A K+ +
Sbjct: 168 DPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA-----KSKLNI 222
Query: 178 LEKAEPEC 185
L++ +C
Sbjct: 223 LQEGHAQC 230
>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
isoform 2 [Homo sapiens]
Length = 318
Score = 60.5 bits (145), Expect = 1e-09
Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 5/123 (4%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH + A G V+ L+ G DP KD+ T LH+AA+ G+ + RL++E R
Sbjct: 49 TLLHFSAARGKERCVRVFLEHG-ADPTVKDLI-GGFTALHYAAMHGRARIARLMLESEYR 106
Query: 119 PCLVTSV---GWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACV 175
++ + GWTP H AA G + ++ L A +D G TP ++A I + +CV
Sbjct: 107 SDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCV 166
Query: 176 AFL 178
L
Sbjct: 167 KIL 169
Score = 59.3 bits (142), Expect = 3e-09
Identities = 42/135 (31%), Positives = 72/135 (53%), Gaps = 7/135 (5%)
Query: 54 KMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLI 113
++ + ++ AVAAGD V+K+L++G PN +D N T LH++A +G+ +R+ +
Sbjct: 11 ELQEELQIQAAVAAGDVHTVRKMLEQGY-SPNGRDA--NGWTLLHFSAARGKERCVRVFL 67
Query: 114 EYGARPCLVTSV-GWTPAHFAAEAGHLNILKTL---HALHAAIDAPDFFGDTPKRIAQIY 169
E+GA P + + G+T H+AA G I + + I+A G TP +A Y
Sbjct: 68 EHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHY 127
Query: 170 GQKACVAFLEKAEPE 184
G+ + V L + + E
Sbjct: 128 GRDSFVRLLLEFKAE 142
Score = 33.9 bits (76), Expect = 0.13
Identities = 28/100 (28%), Positives = 43/100 (43%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A G + + +L+ + TPLH AA G+ +RLL+E+ A
Sbjct: 83 TALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAE 142
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFF 158
++ G TP A + +K L +A ID + F
Sbjct: 143 VDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF 182
Score = 31.2 bits (69), Expect = 0.86
Identities = 21/69 (30%), Positives = 35/69 (50%), Gaps = 2/69 (2%)
Query: 61 LHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPC 120
L AV ++S + L++G D N ++ + +TPLH +A++ + R+L YGA
Sbjct: 184 LRYAVIKSNHSYCRMFLQRG-ADTNLGRLE-DGQTPLHLSALRDDVLCARMLYNYGADTN 241
Query: 121 LVTSVGWTP 129
G TP
Sbjct: 242 TRNYEGQTP 250
>gi|30089994 ankyrin repeat and SOCS box-containing protein 7
isoform 1 [Homo sapiens]
Length = 274
Score = 60.5 bits (145), Expect = 1e-09
Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 5/123 (4%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH + A G V+ L+ G DP KD+ T LH+AA+ G+ + RL++E R
Sbjct: 49 TLLHFSAARGKERCVRVFLEHG-ADPTVKDLI-GGFTALHYAAMHGRARIARLMLESEYR 106
Query: 119 PCLVTSV---GWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACV 175
++ + GWTP H AA G + ++ L A +D G TP ++A I + +CV
Sbjct: 107 SDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCV 166
Query: 176 AFL 178
L
Sbjct: 167 KIL 169
Score = 59.3 bits (142), Expect = 3e-09
Identities = 42/135 (31%), Positives = 72/135 (53%), Gaps = 7/135 (5%)
Query: 54 KMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLI 113
++ + ++ AVAAGD V+K+L++G PN +D N T LH++A +G+ +R+ +
Sbjct: 11 ELQEELQIQAAVAAGDVHTVRKMLEQGY-SPNGRDA--NGWTLLHFSAARGKERCVRVFL 67
Query: 114 EYGARPCLVTSV-GWTPAHFAAEAGHLNILKTL---HALHAAIDAPDFFGDTPKRIAQIY 169
E+GA P + + G+T H+AA G I + + I+A G TP +A Y
Sbjct: 68 EHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHY 127
Query: 170 GQKACVAFLEKAEPE 184
G+ + V L + + E
Sbjct: 128 GRDSFVRLLLEFKAE 142
Score = 33.9 bits (76), Expect = 0.13
Identities = 28/100 (28%), Positives = 43/100 (43%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A G + + +L+ + TPLH AA G+ +RLL+E+ A
Sbjct: 83 TALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAE 142
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFF 158
++ G TP A + +K L +A ID + F
Sbjct: 143 VDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF 182
Score = 31.2 bits (69), Expect = 0.86
Identities = 21/69 (30%), Positives = 35/69 (50%), Gaps = 2/69 (2%)
Query: 61 LHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPC 120
L AV ++S + L++G D N ++ + +TPLH +A++ + R+L YGA
Sbjct: 184 LRYAVIKSNHSYCRMFLQRG-ADTNLGRLE-DGQTPLHLSALRDDVLCARMLYNYGADTN 241
Query: 121 LVTSVGWTP 129
G TP
Sbjct: 242 TRNYEGQTP 250
>gi|34304383 Usher syndrome 1G protein [Homo sapiens]
Length = 461
Score = 60.5 bits (145), Expect = 1e-09
Identities = 41/118 (34%), Positives = 56/118 (47%), Gaps = 5/118 (4%)
Query: 62 HQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCL 121
H+A G L+K+ +K L P D + TP WAA G +E +RL++ G P
Sbjct: 6 HRAARDGYLELLKEATRKELNAP-----DEDGMTPTLWAAYHGNLESLRLIVSRGGDPDK 60
Query: 122 VTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLE 179
G TP H AA GHL+ L L + A I D TP +A + G CV +L+
Sbjct: 61 CDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLD 118
Score = 40.8 bits (94), Expect = 0.001
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 3/93 (3%)
Query: 58 MTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
MT A G+ ++ I+ +G DP+ D+ W + TPLH AA G + + L+ +GA
Sbjct: 33 MTPTLWAAYHGNLESLRLIVSRG-GDPDKCDI-WGN-TPLHLAASNGHLHCLSFLVSFGA 89
Query: 118 RPCLVTSVGWTPAHFAAEAGHLNILKTLHALHA 150
+ + TP AA GH+ ++ L ++ A
Sbjct: 90 NIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAA 122
Score = 29.3 bits (64), Expect = 3.3
Identities = 20/60 (33%), Positives = 29/60 (48%), Gaps = 3/60 (5%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A + G + ++ G N +D + TPL AA+KG ME +R L A+
Sbjct: 67 TPLHLAASNGHLHCLSFLVSFGA---NIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
>gi|10863929 ribonuclease L [Homo sapiens]
Length = 741
Score = 60.1 bits (144), Expect = 2e-09
Identities = 42/128 (32%), Positives = 68/128 (53%), Gaps = 2/128 (1%)
Query: 53 AKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLL 112
A + D L +AV D LV+++L+ G + N+++ + TPLH A + +++ LL
Sbjct: 21 AAVEDNHLLIKAVQNEDVDLVQQLLEGG-ANVNFQEEE-GGWTPLHNAVQMSREDIVELL 78
Query: 113 IEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQK 172
+ +GA P L G TP AA AG + +LK + A ++ DF+G T A +YG+
Sbjct: 79 LRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKV 138
Query: 173 ACVAFLEK 180
+ FL K
Sbjct: 139 KALKFLYK 146
Score = 35.4 bits (80), Expect = 0.045
Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 3/95 (3%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH AV +V+ +L+ G DP + N TP AAI G +++++L + GA
Sbjct: 61 TPLHNAVQMSREDIVELLLRHG-ADPVLRKK--NGATPFILAAIAGSVKLLKLFLSKGAD 117
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
G+T AA G + LK L+ A ++
Sbjct: 118 VNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVN 152
Score = 35.4 bits (80), Expect = 0.045
Identities = 34/119 (28%), Positives = 52/119 (43%), Gaps = 14/119 (11%)
Query: 52 LAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRL 111
L K + T A AG L+K L KG + + D+ T AA+ G+++ ++
Sbjct: 87 LRKKNGATPFILAAIAGSVKLLKLFLSKGA---DVNECDFYGFTAFMEAAVYGKVKALKF 143
Query: 112 LIEYGARPCL----------VTSVGWTPAHFAAEAGHLNILK-TLHALHAAIDAPDFFG 159
L + GA L + G T AAE GH+ +LK L + A ++A D G
Sbjct: 144 LYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMG 202
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 60.1 bits (144), Expect = 2e-09
Identities = 42/142 (29%), Positives = 68/142 (47%), Gaps = 5/142 (3%)
Query: 48 SAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQME 107
+A++ T L A A G+ +V+ +L +GL + + D W TPLH AA +G
Sbjct: 805 AAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGW---TPLHMAAFEGHRL 861
Query: 108 VIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQ 167
+ LIE GAR + + G P A++ GH + ++ L + ID + G R+A
Sbjct: 862 ICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAA 921
Query: 168 IYGQKACV--AFLEKAEPECQD 187
+ G + V F A+ C+D
Sbjct: 922 LEGHRDIVELLFSHGADVNCKD 943
Score = 50.1 bits (118), Expect = 2e-06
Identities = 39/120 (32%), Positives = 52/120 (43%), Gaps = 3/120 (2%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T L A + G S+V +L G +D RT L A+ +G +EV+R L++ G
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAA---VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLD 839
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
GWTP H AA GH I + L A + D G P +A G CV L
Sbjct: 840 ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 899
Score = 50.1 bits (118), Expect = 2e-06
Identities = 39/131 (29%), Positives = 64/131 (48%), Gaps = 3/131 (2%)
Query: 50 MELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVI 109
+E + T LH + G +V+ ++ D N D + R+ L AA +G ++V+
Sbjct: 972 VEASDAEGRTALHVSCWQGHMEMVQVLIAYH-ADVNAADNE--KRSALQSAAWQGHVKVV 1028
Query: 110 RLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIY 169
+LLIE+GA + G T AA+ GH+++++ L A + D FG T R+A
Sbjct: 1029 QLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKN 1088
Query: 170 GQKACVAFLEK 180
G + LEK
Sbjct: 1089 GHSQIIKLLEK 1099
Score = 47.8 bits (112), Expect = 9e-06
Identities = 39/114 (34%), Positives = 56/114 (49%), Gaps = 9/114 (7%)
Query: 68 GDYSLVKKILKKGLCDPNYKDVDWNDR---TPLHWAAIKGQMEVIRLLIEYGARPCLVTS 124
G S+V ++ +G +VD D+ TPL AA +G ++V+ LL+E GA +
Sbjct: 726 GHASVVSLLIDRGA------EVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDN 779
Query: 125 VGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
G TP AA GH +++ TL AA+D+ D G T IA G V L
Sbjct: 780 NGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
Score = 46.2 bits (108), Expect = 3e-05
Identities = 41/122 (33%), Positives = 56/122 (45%), Gaps = 8/122 (6%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAI-----KGQMEVIRLLI 113
T L A G +V+ +L G + N++DVD RT L AA+ KG V+ LLI
Sbjct: 679 TALIAAAYMGHREIVEHLLDHG-AEVNHEDVD--GRTALSVAALCVPASKGHASVVSLLI 735
Query: 114 EYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKA 173
+ GA G TP AA GH++++ L A +D D G TP A G +
Sbjct: 736 DRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHAS 795
Query: 174 CV 175
V
Sbjct: 796 VV 797
Score = 42.0 bits (97), Expect = 5e-04
Identities = 34/100 (34%), Positives = 46/100 (46%), Gaps = 2/100 (2%)
Query: 90 DWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALH 149
D N RT L AA G ++V+ LL+ GA + + G TP AA GH ++ L
Sbjct: 542 DSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCG 601
Query: 150 AAIDAPDFFGDTPKRIAQIYGQKACVAFLEKA--EPECQD 187
A I+ D G T R A G V+ L A + +C D
Sbjct: 602 ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCAD 641
Score = 41.6 bits (96), Expect = 6e-04
Identities = 40/145 (27%), Positives = 58/145 (40%), Gaps = 10/145 (6%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T L A +G +V ++ +G + + D + TPL AA +G +V+ LI GA
Sbjct: 547 TLLANAAYSGSLDVVNLLVSRGA---DLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGAN 603
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACV--- 175
GWT AA GH ++ L +D D T R A G + V
Sbjct: 604 INHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNL 663
Query: 176 ----AFLEKAEPECQDHRCAAQQKG 196
A + KA+ E + AA G
Sbjct: 664 LQHGAEVNKADNEGRTALIAAAYMG 688
Score = 41.2 bits (95), Expect = 8e-04
Identities = 28/96 (29%), Positives = 45/96 (46%), Gaps = 3/96 (3%)
Query: 61 LHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPC 120
L A G +V+ + G D N KD D R L+ A++ Q+ + +E GA
Sbjct: 917 LRVAALEGHRDIVELLFSHG-ADVNCKDAD--GRPTLYILALENQLTMAEYFLENGANVE 973
Query: 121 LVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPD 156
+ G T H + GH+ +++ L A HA ++A D
Sbjct: 974 ASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAAD 1009
Score = 37.4 bits (85), Expect = 0.012
Identities = 21/57 (36%), Positives = 32/57 (56%)
Query: 95 TPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAA 151
T L AA +G ++V+++L+E+GA P G T AA+ GH I+K L A+
Sbjct: 1047 TALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103
Score = 34.3 bits (77), Expect = 0.10
Identities = 30/110 (27%), Positives = 47/110 (42%), Gaps = 3/110 (2%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T L A G +V +L G+ D + RT L AA G +++ L+++GA
Sbjct: 613 TALRSAAWGGHTEVVSALLYAGV---KVDCADADSRTALRAAAWGGHEDIVLNLLQHGAE 669
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQI 168
+ G T AA GH I++ L A ++ D G T +A +
Sbjct: 670 VNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAAL 719
Score = 31.6 bits (70), Expect = 0.66
Identities = 33/129 (25%), Positives = 48/129 (37%), Gaps = 3/129 (2%)
Query: 50 MELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVI 109
+E+ T L A G +V ++ C N D + T L AA G EV+
Sbjct: 571 LEIEDAHGHTPLTLAARQGHTKVVNCLIG---CGANINHTDQDGWTALRSAAWGGHTEVV 627
Query: 110 RLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIY 169
L+ G + + T AA GH +I+ L A ++ D G T A
Sbjct: 628 SALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYM 687
Query: 170 GQKACVAFL 178
G + V L
Sbjct: 688 GHREIVEHL 696
>gi|103471993 huntingtin interacting protein 14 [Homo sapiens]
Length = 632
Score = 59.7 bits (143), Expect = 2e-09
Identities = 43/146 (29%), Positives = 70/146 (47%), Gaps = 6/146 (4%)
Query: 20 SHISMHSPGGLTTTKMAGPLPRVSDSLFSAMELAK--MSDMTKLHQAVAAGDYSLVKKIL 77
+HI +S + G R + + + ++ + ++T LH A LVK +
Sbjct: 51 THIDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYI 110
Query: 78 KKG-LCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEA 136
KG + D D++ TPLHWA +G + ++ L++YGA P L+ G + H AA+
Sbjct: 111 SKGAIVDQLGGDLN---STPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQF 167
Query: 137 GHLNILKTLHALHAAIDAPDFFGDTP 162
GH +I+ L A +D D G TP
Sbjct: 168 GHTSIVAYLIAKGQDVDMMDQNGMTP 193
Score = 43.9 bits (102), Expect = 1e-04
Identities = 33/120 (27%), Positives = 59/120 (49%), Gaps = 10/120 (8%)
Query: 63 QAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLV 122
+A G Y +++++ G + + D + T LHWAAI ++++++ I GA +V
Sbjct: 63 KATQYGIYERCRELVEAGY---DVRQPDKENVTLLHWAAINNRIDLVKYYISKGA---IV 116
Query: 123 TSVGW----TPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
+G TP H+A GHL+++ L A D G + +A +G + VA+L
Sbjct: 117 DQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYL 176
Score = 36.6 bits (83), Expect = 0.020
Identities = 32/112 (28%), Positives = 53/112 (47%), Gaps = 11/112 (9%)
Query: 61 LHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDR---TPLHWAAIKGQ-MEVIRLLIEYG 116
+H A G S+V ++ KG +DVD D+ TPL WAA + ++ RLL+ +
Sbjct: 161 IHLAAQFGHTSIVAYLIAKG------QDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFN 214
Query: 117 ARPCLVTSVGWTPA-HFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQ 167
L A H+A AG+ ++ L A +DA + G++ +A+
Sbjct: 215 VSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAK 266
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 59.7 bits (143), Expect = 2e-09
Identities = 40/127 (31%), Positives = 59/127 (46%), Gaps = 3/127 (2%)
Query: 52 LAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRL 111
L + + T L A G +V+++LK C N + D T L WA KG+ +V+ L
Sbjct: 66 LEDLDNWTALISASKEGHVHIVEELLK---CGVNLEHRDMGGWTALMWACYKGRTDVVEL 122
Query: 112 LIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQ 171
L+ +GA P + P +AA GH +I+ L A ++ D +G TP A G
Sbjct: 123 LLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGH 182
Query: 172 KACVAFL 178
CV L
Sbjct: 183 LECVKHL 189
Score = 47.0 bits (110), Expect = 2e-05
Identities = 38/129 (29%), Positives = 63/129 (48%), Gaps = 10/129 (7%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVD---WNDRTPLHWAAIKGQMEVIRLLIEY 115
T L AV G +V+ +L+K Y D+D +++T L+WA KG ++R +++
Sbjct: 271 TVLIGAVRGGHVEIVRALLQK------YADIDIRGQDNKTALYWAVEKGNATMVRDILQC 324
Query: 116 GARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACV 175
+ T G TP A + ++ +++ L A + A D GDTP IA I G+ +
Sbjct: 325 NPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA-IRGRSRKL 383
Query: 176 AFLEKAEPE 184
A L P+
Sbjct: 384 AELLLRNPK 392
Score = 45.4 bits (106), Expect = 4e-05
Identities = 32/104 (30%), Positives = 48/104 (46%), Gaps = 3/104 (2%)
Query: 50 MELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVI 109
+E M T L A G +V+ +L G N P+ WAA +G +++
Sbjct: 97 LEHRDMGGWTALMWACYKGRTDVVELLLSHGA---NPSVTGLYSVYPIIWAAGRGHADIV 153
Query: 110 RLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
LL++ GA+ G TP +AA GHL +K L A+ A +D
Sbjct: 154 HLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD 197
Score = 40.8 bits (94), Expect = 0.001
Identities = 31/98 (31%), Positives = 48/98 (48%), Gaps = 3/98 (3%)
Query: 56 SDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEY 115
+ MT L AV G VK+ILK+ +PN D + T L A+ +G E+++ L++
Sbjct: 202 NSMTALIVAVKGGYTQSVKEILKR---NPNVNLTDKDGNTALMIASKEGHTEIVQDLLDA 258
Query: 116 GARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
G + G T A GH+ I++ L +A ID
Sbjct: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADID 296
Score = 38.9 bits (89), Expect = 0.004
Identities = 30/95 (31%), Positives = 47/95 (49%), Gaps = 3/95 (3%)
Query: 87 KDVDWND---RTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILK 143
KDVD + +TPL AA +G +E+++ LI+ GA L WT A++ GH++I++
Sbjct: 29 KDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVE 88
Query: 144 TLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
L ++ D G T A G+ V L
Sbjct: 89 ELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELL 123
Score = 30.8 bits (68), Expect = 1.1
Identities = 33/134 (24%), Positives = 48/134 (35%), Gaps = 42/134 (31%)
Query: 64 AVAAGDYSLVKKILKKGL---CDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA--- 117
A G +V +L+ G C Y TPL WAA KG +E ++ L+ GA
Sbjct: 144 AAGRGHADIVHLLLQNGAKVNCSDKY------GTTPLVWAARKGHLECVKHLLAMGADVD 197
Query: 118 ------RPCLVTSV------------------------GWTPAHFAAEAGHLNILKTLHA 147
L+ +V G T A++ GH I++ L
Sbjct: 198 QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLD 257
Query: 148 LHAAIDAPDFFGDT 161
++ PD GDT
Sbjct: 258 AGTYVNIPDRSGDT 271
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 59.3 bits (142), Expect = 3e-09
Identities = 55/195 (28%), Positives = 83/195 (42%), Gaps = 19/195 (9%)
Query: 11 PQISHKTGCSHISMHSPGGLTTTKMAG---PLPRVS--------DSLFSAMELAKMSDMT 59
P +S + H P G T AG P P +S +S A++ K +
Sbjct: 677 PPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLR 736
Query: 60 ----KLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEY 115
+L+ + G+ V +L G+ DPN+K N R+PLH AA G +++ +L++
Sbjct: 737 FHPKQLYFSARQGELQKVLLMLVDGI-DPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQA 795
Query: 116 GARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACV 175
GA + TP AAE HL +K L A +D D G T +A G V
Sbjct: 796 GANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVV 855
Query: 176 AFL---EKAEPECQD 187
+L + + CQD
Sbjct: 856 QYLLSNGQMDVNCQD 870
Score = 41.6 bits (96), Expect = 6e-04
Identities = 33/100 (33%), Positives = 47/100 (47%), Gaps = 6/100 (6%)
Query: 59 TKLHQAVAAGDYSLVKKILKKG-LCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGA 117
T L +A VK ++K G L DP D T LH AA KG EV++ L+ G
Sbjct: 808 TPLMEAAENNHLEAVKYLIKAGALVDPK----DAEGSTCLHLAAKKGHYEVVQYLLSNGQ 863
Query: 118 RPC-LVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPD 156
GWTP +A E H++++K L + + I+ D
Sbjct: 864 MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRD 903
Score = 37.7 bits (86), Expect = 0.009
Identities = 30/110 (27%), Positives = 49/110 (44%), Gaps = 3/110 (2%)
Query: 72 LVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAH 131
LVK +L KG D N +D + N LHWAA G +++ +L+ V G +P H
Sbjct: 888 LVKLLLSKG-SDINIRDNEEN--ICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLH 944
Query: 132 FAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKA 181
AA + + + + + + G+TP + A + Q + KA
Sbjct: 945 IAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKA 994
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 58.5 bits (140), Expect = 5e-09
Identities = 48/157 (30%), Positives = 71/157 (45%), Gaps = 8/157 (5%)
Query: 36 AGPLPRVSDSLFSAMELAKMSDM---TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWN 92
+G L + +S+ + LA +D T LH A +AG +V+ +L+ G+ + D W+
Sbjct: 16 SGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWS 75
Query: 93 DRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAI 152
PLH AA G+ E+++ L+ GA+ V G TP H+AA I L A
Sbjct: 76 ---PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132
Query: 153 DAPDFFGDTPKRIAQIYGQKACVAFL--EKAEPECQD 187
DA D + T A G + L KA QD
Sbjct: 133 DAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQD 169
Score = 57.0 bits (136), Expect = 1e-08
Identities = 35/101 (34%), Positives = 49/101 (48%), Gaps = 2/101 (1%)
Query: 90 DWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALH 149
D + RT LHWA G E++ L++ G GW+P H AA AG I+K L
Sbjct: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
Query: 150 AAIDAPDFFGDTPKRIAQIYGQ-KACVAFLE-KAEPECQDH 188
A ++A + G TP A + + V LE A P+ +DH
Sbjct: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDH 137
Score = 56.2 bits (134), Expect = 2e-08
Identities = 38/106 (35%), Positives = 54/106 (50%), Gaps = 3/106 (2%)
Query: 61 LHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPC 120
LH A +AG +VK +L KG V+ N TPLH+AA K + E+ +L+E GA P
Sbjct: 77 LHIAASAGRDEIVKALLGKGA---QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
Query: 121 LVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIA 166
T H AA G+L ++ L A+ + D G+TP +A
Sbjct: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179
Score = 43.9 bits (102), Expect = 1e-04
Identities = 31/109 (28%), Positives = 55/109 (50%), Gaps = 3/109 (2%)
Query: 59 TKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGAR 118
T LH A + + + +L+ G +P+ KD + T +H AA KG +++I +L+ Y A
Sbjct: 108 TPLHYAASKNRHEIAVMLLEGG-ANPDAKD--HYEATAMHRAAAKGNLKMIHILLYYKAS 164
Query: 119 PCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAIDAPDFFGDTPKRIAQ 167
+ + G TP H A + + K L + A+I + TP ++A+
Sbjct: 165 TNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,100,492
Number of Sequences: 37866
Number of extensions: 438716
Number of successful extensions: 3036
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 297
Number of HSP's successfully gapped in prelim test: 65
Number of HSP's that attempted gapping in prelim test: 1256
Number of HSP's gapped (non-prelim): 1242
length of query: 245
length of database: 18,247,518
effective HSP length: 100
effective length of query: 145
effective length of database: 14,460,918
effective search space: 2096833110
effective search space used: 2096833110
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.