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Search of human proteins with 239750672
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239750672 PREDICTED: hypothetical protein [Homo sapiens]
(627 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239750672 PREDICTED: hypothetical protein [Homo sapiens] 1204 0.0
gi|239744982 PREDICTED: hypothetical protein [Homo sapiens] 1204 0.0
gi|239756174 PREDICTED: hypothetical protein [Homo sapiens] 1194 0.0
gi|148746195 trichohyalin [Homo sapiens] 101 2e-21
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 91 4e-18
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 90 7e-18
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 89 2e-17
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 89 2e-17
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 87 5e-17
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 86 8e-17
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 86 8e-17
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 86 8e-17
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 86 8e-17
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] 81 3e-15
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 80 4e-15
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 80 4e-15
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 80 4e-15
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 80 4e-15
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 80 4e-15
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 80 4e-15
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 80 4e-15
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 80 4e-15
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 80 4e-15
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 78 2e-14
gi|224593756 hypothetical protein LOC164127 [Homo sapiens] 77 4e-14
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 77 5e-14
gi|219803769 trichoplein [Homo sapiens] 74 3e-13
gi|14150056 trichoplein [Homo sapiens] 74 3e-13
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti... 73 9e-13
gi|56549694 enabled homolog isoform a [Homo sapiens] 72 1e-12
>gi|239750672 PREDICTED: hypothetical protein [Homo sapiens]
Length = 627
Score = 1204 bits (3114), Expect = 0.0
Identities = 627/627 (100%), Positives = 627/627 (100%)
Query: 1 MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60
MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS
Sbjct: 1 MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60
Query: 61 ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120
ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC
Sbjct: 61 ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120
Query: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL 180
AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL
Sbjct: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL 180
Query: 181 FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 240
FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG
Sbjct: 181 FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 240
Query: 241 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 300
SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST
Sbjct: 241 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 300
Query: 301 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 360
TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA
Sbjct: 301 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 360
Query: 361 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 420
LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR
Sbjct: 361 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 420
Query: 421 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 480
GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ
Sbjct: 421 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 480
Query: 481 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540
REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ
Sbjct: 481 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540
Query: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 600
RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE
Sbjct: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 600
Query: 601 KVREETNTRSFDRMVREAQLHASLDRK 627
KVREETNTRSFDRMVREAQLHASLDRK
Sbjct: 601 KVREETNTRSFDRMVREAQLHASLDRK 627
>gi|239744982 PREDICTED: hypothetical protein [Homo sapiens]
Length = 627
Score = 1204 bits (3114), Expect = 0.0
Identities = 627/627 (100%), Positives = 627/627 (100%)
Query: 1 MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60
MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS
Sbjct: 1 MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60
Query: 61 ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120
ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC
Sbjct: 61 ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120
Query: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL 180
AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL
Sbjct: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL 180
Query: 181 FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 240
FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG
Sbjct: 181 FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 240
Query: 241 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 300
SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST
Sbjct: 241 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 300
Query: 301 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 360
TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA
Sbjct: 301 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 360
Query: 361 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 420
LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR
Sbjct: 361 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 420
Query: 421 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 480
GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ
Sbjct: 421 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 480
Query: 481 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540
REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ
Sbjct: 481 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540
Query: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 600
RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE
Sbjct: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 600
Query: 601 KVREETNTRSFDRMVREAQLHASLDRK 627
KVREETNTRSFDRMVREAQLHASLDRK
Sbjct: 601 KVREETNTRSFDRMVREAQLHASLDRK 627
>gi|239756174 PREDICTED: hypothetical protein [Homo sapiens]
Length = 625
Score = 1194 bits (3090), Expect = 0.0
Identities = 624/627 (99%), Positives = 625/627 (99%), Gaps = 2/627 (0%)
Query: 1 MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60
MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS
Sbjct: 1 MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60
Query: 61 ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120
ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC
Sbjct: 61 ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120
Query: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL 180
AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAER+RIMREEKRRL
Sbjct: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERDRIMREEKRRL 180
Query: 181 FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 240
FTPLSPAAAAAAAAA SAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG
Sbjct: 181 FTPLSPAAAAAAAAA--SAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 238
Query: 241 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 300
SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST
Sbjct: 239 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 298
Query: 301 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 360
TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA
Sbjct: 299 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 358
Query: 361 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 420
LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR
Sbjct: 359 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 418
Query: 421 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 480
GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ
Sbjct: 419 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 478
Query: 481 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540
REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ
Sbjct: 479 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 538
Query: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 600
RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE
Sbjct: 539 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 598
Query: 601 KVREETNTRSFDRMVREAQLHASLDRK 627
KVREETNTRSFDRMVREAQLHASLDRK
Sbjct: 599 KVREETNTRSFDRMVREAQLHASLDRK 625
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 101 bits (251), Expect = 2e-21
Identities = 83/266 (31%), Positives = 134/266 (50%), Gaps = 21/266 (7%)
Query: 353 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRR-A 411
ER R+ L +E L EQ+ + ELQR EEREK+R EQ R+
Sbjct: 881 ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQR---------EEREKRRRQEQERQYR 931
Query: 412 WAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRK 471
Q+++ + REERE RR++R ER + ++L +++ L E E+ R++R +K
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQER--ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989
Query: 472 LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEA 531
++E+ L+Q EE L RE E+ RR+ +R + R++ +LQ+E+ +L R ER +
Sbjct: 990 YREEEELQQEEEQLL--REEREKRRRQEWER----QYRKKDELQQEEEQLLREEREKRR- 1042
Query: 532 LLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARST 591
LQ R RQ R+E E L+ E LG +E + R+ + E+L +E L
Sbjct: 1043 -LQERERQYREEEE-LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100
Query: 592 ARASFHVREKVREETNTRSFDRMVRE 617
R R+ EE + ++++RE
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLRE 1126
Score = 99.8 bits (247), Expect = 7e-21
Identities = 85/283 (30%), Positives = 136/283 (48%), Gaps = 29/283 (10%)
Query: 343 RAERGLRGVPERDRKIAAL-MLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREK 401
R ERG + +RDRK L + +EE L Q + E Q+V +Q +ER+ E
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVR-RQEQERKFMED 1600
Query: 402 QRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAE 461
++ L R+ Q+ + R R+ RE+ + + R+ Q +ER R+ E + LRR+ E
Sbjct: 1601 EQQLR--RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE 1658
Query: 462 RAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKREL 521
+ R DR RK ++E+ L LQEG E +Q+RR+ R R +++Q + +RE++ L
Sbjct: 1659 QQLRHDRDRKFREEEQL------LQEGEE--QQLRRQERDRKFREEEQQLRRQERERKFL 1710
Query: 522 SRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRER 581
++ R + L ++ +E E LR E R QE Y RK+ EQL R
Sbjct: 1711 QEEQQLRRQEL-----ERKFREEEQLRQETEQEQLRRQERY------RKILEEEQL-RPE 1758
Query: 582 RSALESARSTARASFHVREKVREE-----TNTRSFDRMVREAQ 619
R + R F E++R+E ++ DR RE +
Sbjct: 1759 REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEE 1801
Score = 98.6 bits (244), Expect = 2e-20
Identities = 91/323 (28%), Positives = 150/323 (46%), Gaps = 40/323 (12%)
Query: 325 LSHSPQTAQHVERIVR-QVRAERGLRGVPERDRKIAALMLARHQE-ELLLLEQRAAAHGQ 382
LS P + ER +R + R +R R +PE + K R +E EL LE+ +
Sbjct: 784 LSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRR 843
Query: 383 WELQRVHAKQRREREEREKQRALEQGR-RAWAAQVEERRGRRG----------------- 424
Q++ ++ +E++E++R+ EQ R + W Q+EE R RR
Sbjct: 844 ERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903
Query: 425 ---REEREAARRRQRQYERSEERRRELAERQGL------LRRERAERAAREDRLRKLQQE 475
+EE E +R +R+ R +E+ R+ E + L L RE E+ R++R R+ +++
Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963
Query: 476 QNLKQREEGLQ-EGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQ 534
+ L+Q+EE L E E+ + RE+ R Q++E QL RE+RE +R R E Q
Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE----KRRRQEWERQ 1019
Query: 535 GRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARA 594
R + + Q+ E E R QE R+ E+L +E L R T R
Sbjct: 1020 YRKKDELQQEEEQLLREEREKRRLQERE------RQYREEEELQQEEEQLLGEERETRRR 1073
Query: 595 SFHVREKVREETNTRSFDRMVRE 617
R+ +EE + ++++RE
Sbjct: 1074 QELERQYRKEEELQQEEEQLLRE 1096
Score = 96.7 bits (239), Expect = 6e-20
Identities = 87/297 (29%), Positives = 145/297 (48%), Gaps = 19/297 (6%)
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLE---QRAAAHGQWELQRVHAKQ-RRE 395
R+ R +R + E++ + +L + +E+L E QR + +L+++ ++ RRE
Sbjct: 230 RRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289
Query: 396 REEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEER-RRELAERQGL 454
R+E E+Q+ + + + EE R + E RE RR++Q ER E++ RRE ER+
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQ 349
Query: 455 LRRERAERAAREDRLRKLQQEQNLKQ---REEGLQEGRE--RAEQIRRE----RAQRAAR 505
R E RE +LR+ Q+E+ +Q RE+ L+ ++ R +Q+RRE R Q+ R
Sbjct: 350 QLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 409
Query: 506 AKQ-RQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEH 564
+Q R+E QL+RE++ E RHE + R+QR +RE + L R +E H
Sbjct: 410 EQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE--QEERRDWLKREEETERH 467
Query: 565 LAIGRKLERSEQLTRERRSALESARSTARASFHVR--EKVREETNTRSFDRMVREAQ 619
RK + ERR R R +++R E R R+ R+ +
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEE 524
Score = 96.7 bits (239), Expect = 6e-20
Identities = 91/322 (28%), Positives = 148/322 (45%), Gaps = 28/322 (8%)
Query: 318 RSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRA 377
R F +L H Q + +E R R ER + + E + L +++L R
Sbjct: 1360 RKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ----LRCQEREQQLRQDRDRK 1415
Query: 378 AAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAA--QVEERRGRRGREEREAARRRQ 435
+ +L R + R+ REE ++ R E+ R+ Q+ + R R+ REE + + R+
Sbjct: 1416 FREEEQQLSR-QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQERE 1474
Query: 436 RQYERSEERRRELAERQGLLRRERAERAAREDRLRK-------LQQEQNL---KQREEGL 485
Q +ER R+ E + LRR+ +R RE LR L++EQ L +++ + L
Sbjct: 1475 EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFL 1534
Query: 486 QEGRERAEQIRRERAQRAARAKQRQEGQL--QREKRELSRAERARHEALLQGRTRQQRQE 543
QE ++ Q R ++ ++ K R+E QL +RE+++LSR ER R L + + R+Q QE
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQE 1594
Query: 544 REGLRSSLEASLGRAQENYEHL--AIGRKLERSEQLTRERRS----ALESARSTARASFH 597
R+ + + R QE + L RK EQL +ER E R
Sbjct: 1595 RKFMEDEQQL---RRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQ 1651
Query: 598 VREKVREETNTRSFDRMVREAQ 619
+R + RE+ DR RE +
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEE 1673
Score = 94.4 bits (233), Expect = 3e-19
Identities = 81/301 (26%), Positives = 136/301 (45%), Gaps = 23/301 (7%)
Query: 345 ERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQW-----ELQRVHAKQRREREER 399
+R L+ E+ RK+ L R ++E +QR Q E +R ++RRE++ER
Sbjct: 268 QRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER 327
Query: 400 EKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRE- 458
+Q+ + ++ Q E R + RE+ E R +Q + E+ EERR + R+ LRRE
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387
Query: 459 ---------RAERAAREDRLRKLQQ---EQNLKQREEGLQEGRERAEQIRRERAQRAARA 506
R ++ RE +LR+ QQ EQ L++ ++ +E E + + E+ +R R
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447
Query: 507 KQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLA 566
K+ QE + KRE ER E Q R Q +ER LE R Q+
Sbjct: 448 KREQEERRDWLKRE-EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERRE-- 504
Query: 567 IGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDR 626
++L R ++ RE+R + + +++R E R + RE + +R
Sbjct: 505 --QQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562
Query: 627 K 627
+
Sbjct: 563 R 563
Score = 90.5 bits (223), Expect = 4e-18
Identities = 82/286 (28%), Positives = 142/286 (49%), Gaps = 21/286 (7%)
Query: 343 RAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRER------ 396
R ER R E++R+ + +EE LL E+R Q E +R + K ++ +
Sbjct: 915 REEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ-ERERQYRKDKKLQQKEEQL 973
Query: 397 --EEREKQRALEQGRR-AWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
EE EK+R E+ ++ ++++ + REERE +RR++++ER ++ EL + +
Sbjct: 974 LGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE--KRRRQEWERQYRKKDELQQEEE 1031
Query: 454 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
L RE E+ ++R R+ ++E+ L+Q EE L G ER E RR+ +R + R+E +
Sbjct: 1032 QLLREEREKRRLQERERQYREEEELQQEEEQLL-GEER-ETRRRQELER----QYRKEEE 1085
Query: 514 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
LQ+E+ +L R E + Q R RQ R+E E L+ E L +E + R+
Sbjct: 1086 LQQEEEQLLREEPEKRRR--QERERQCREEEE-LQQEEEQLLREEREKRRRQELERQYRE 1142
Query: 574 SEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQ 619
E++ +E L R R+ EE + ++++RE Q
Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188
Score = 90.1 bits (222), Expect = 5e-18
Identities = 78/306 (25%), Positives = 140/306 (45%), Gaps = 26/306 (8%)
Query: 336 ERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRE 395
E +++ R E R RDR++ R +++ ++R A G+ + ++ ++R+
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQE-QERELAEGEEQSEKQERLEQRD 165
Query: 396 REERE----KQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAER 451
R+ R+ +QR Q R A+ E+ + +G E E Q + E RR+ E
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE 225
Query: 452 QGLLRRERAERAAREDRLR--------------KLQQEQNLKQREEGLQEGRERAEQIRR 497
+ RRER +R +E+ + KLQ+E+ +QRE LQE E+ ++ R
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE--LQEEEEQLRKLER 283
Query: 498 ERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGR 557
+ +R + +++Q+ +L+RE++ + E R E Q R+Q++ RE E L R
Sbjct: 284 QELRRERQEEEQQQQRLRREQQLRRKQEEERREQ--QEERREQQERREQQEERREQQLRR 341
Query: 558 AQENYEHLAIGRKLE---RSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRM 614
QE + R+ E R +QL RE+ + +++R E R ++
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL 401
Query: 615 VREAQL 620
RE QL
Sbjct: 402 RREQQL 407
Score = 90.1 bits (222), Expect = 5e-18
Identities = 86/300 (28%), Positives = 140/300 (46%), Gaps = 26/300 (8%)
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELL-LLEQRAAAHGQWELQRVHAKQRREREE 398
RQ+ E G R +R + L Q E LEQR EL R QR+E +E
Sbjct: 127 RQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWR----QRQEWQE 182
Query: 399 REKQRALEQ------GRRAWAAQVEERRGRR--------GREEREAARRRQRQYERSEER 444
RE++RA E+ G EE+ RR GREE++ RR ++ EE
Sbjct: 183 REERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEE 242
Query: 445 RRELAERQGLLRRERAERAARE-DRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRA 503
+E +R+ +LR+E + E R R+LQ+E+ ++ E + RER E+ ++++ R
Sbjct: 243 EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR 302
Query: 504 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQE--- 560
+ +R++ + +RE++E R ++ R E + R +Q R+E+E R E L R QE
Sbjct: 303 EQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR---EQQLRREQEEER 359
Query: 561 NYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQL 620
+ L ++ ER EQ R + + +++R E R ++ RE QL
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419
Score = 90.1 bits (222), Expect = 5e-18
Identities = 84/284 (29%), Positives = 139/284 (48%), Gaps = 36/284 (12%)
Query: 340 RQVRAERGLRGVPERDR-------KIAALMLARHQEEL---LLLEQRAAAHGQ----WEL 385
+Q+R E+ LR E +R + L R QEE L E+ H Q +L
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476
Query: 386 QRVHAKQRRER----EEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERS 441
+R ++RRER EE E++ E+ + + EERR +R + + E R +QR
Sbjct: 477 KRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ 536
Query: 442 EERRRELAERQGLLRRE---RAERAAREDRLRKLQQE---QNLKQREEGLQ-----EGRE 490
+ RR + R+ LL+RE R E+ RE RL++ Q+E Q LK+ EE Q E E
Sbjct: 537 QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE 596
Query: 491 RAEQ-IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRS 549
R EQ ++RE +R + ++R+E +L+RE+ E R + LL+ +++R++++ R
Sbjct: 597 RLEQRLKREEVERLEQ-EERREQRLKREE-----PEEERRQQLLKSEEQEERRQQQLRRE 650
Query: 550 SLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTAR 593
E R + E + ++L+R + R + E + AR
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694
Score = 89.7 bits (221), Expect = 7e-18
Identities = 86/293 (29%), Positives = 147/293 (50%), Gaps = 34/293 (11%)
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRE---- 395
+Q+R E+ LR R++++ R +++L +Q + ++ H ++RRE
Sbjct: 393 QQLRREQQLR----REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLK 448
Query: 396 REEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLL 455
RE+ E++ L++ + E R+ + R++ E R R + E EERR + R+ L
Sbjct: 449 REQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLE-EEERREQQERREQQL 507
Query: 456 RRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAAR-AKQRQEGQL 514
RRE+ ER RE RL++ ++E+ L+QR Q Q+RRE+ +R + K+ +E +L
Sbjct: 508 RREQEER--REQRLKRQEEEERLQQRLRSEQ-------QLRREQEERREQLLKREEEKRL 558
Query: 515 QREKRE--LSRAERARHEALL--QGRTRQQRQEREGLRSSLEASLGRAQENYEHL----A 566
++E+RE L R + R + LL + RQQR +RE LE L R E E L
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEERRQQRLKRE-QEERLEQRLKR--EEVERLEQEER 615
Query: 567 IGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQ 619
++L+R E R+ L+S R ++++R E R R+ RE +
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERR----QQQLRREQQERREQRLKREEE 664
Score = 88.2 bits (217), Expect = 2e-17
Identities = 72/236 (30%), Positives = 122/236 (51%), Gaps = 22/236 (9%)
Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
+QRRER++R Q E+ + W + R + + +E +RQR+ + EE+ R+L
Sbjct: 228 QQRRERQDRVFQ---EEEEKEWRKRETVLR-KEEEKLQEEEPQRQRELQEEEEQLRKLER 283
Query: 451 RQGLLRRERAE------RAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAA 504
++ LRRER E R RE +LR+ Q+E+ +Q+EE ++ R +Q R Q
Sbjct: 284 QE--LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR 341
Query: 505 RAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEH 564
++R+E QL+RE+ E R ++ R E + R +Q R+E++ R E L R Q+
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR---EQQLRREQQ---- 394
Query: 565 LAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQL 620
L ++L R +QL RE++ E R +R + EE + + ++ RE +L
Sbjct: 395 LRREQQLRREQQLRREQQLRRE---QQLRREQQLRREQEEERHEQKHEQERREQRL 447
Score = 87.8 bits (216), Expect = 3e-17
Identities = 88/307 (28%), Positives = 143/307 (46%), Gaps = 39/307 (12%)
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
+Q+R E+ LR R++++ R +++L ++ + E +R + +RE+EER
Sbjct: 399 QQLRREQQLR----REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEER 454
Query: 400 -------EKQRALEQGRRAWAAQVEERRGRRGR-------EEREAARRRQRQYERSEERR 445
E+ EQ RR + ++ RR R E RE RR++Q R +E R
Sbjct: 455 RDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER 514
Query: 446 RELAERQGLLRRERAERAAR----EDRLRKLQQ---EQNLKQREEGLQEGRERAEQIRRE 498
RE Q L R+E ER + E +LR+ Q+ EQ LK+ EE E R ++++RE
Sbjct: 515 RE----QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570
Query: 499 RAQR----AARAKQRQEGQLQREKREL--SRAERARHEALLQGRTRQQRQEREGLRSSLE 552
+ +R R ++R++ +L+RE+ E R +R E L Q R+QR +RE
Sbjct: 571 QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERR 630
Query: 553 ASLGRAQENYEHLAIGRKLERSEQLTRERR--SALESARSTARASFHVREKVREETNTRS 610
L +++E E ++L R +Q RE+R E R R E+ RE+
Sbjct: 631 QQLLKSEEQEERRQ--QQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE 688
Query: 611 FDRMVRE 617
RE
Sbjct: 689 EQEQARE 695
Score = 87.4 bits (215), Expect = 4e-17
Identities = 88/315 (27%), Positives = 147/315 (46%), Gaps = 35/315 (11%)
Query: 333 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQ 392
Q R ++ R E+ LR E R+ L R QEE E+R + +L+R ++
Sbjct: 324 QQERREQQEERREQQLRREQEERRE---QQLRREQEE----ERR-----EQQLRREQEEE 371
Query: 393 RREREEREKQ--RALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
RRE++ R +Q R +Q RR + E++ R + RE RR++Q R ++ RRE E
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE 431
Query: 451 RQGLLRRERAERAAREDRLRKLQQEQN--LKQREEGLQEGRER--------AEQIRRER- 499
+ ++ E+ RE RL++ Q+E+ LK+ EE + +ER E+ RRER
Sbjct: 432 ER---HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Query: 500 ----AQRAARAKQRQEGQLQREKREL--SRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
+ ++R+E QL+RE+ E R +R E LQ R R ++Q R E
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 554 SLGRAQE-NYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFD 612
L R +E E ++L+R ++ R++ E R R E++ + +
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608
Query: 613 RMVREAQLHASLDRK 627
R+ +E + L R+
Sbjct: 609 RLEQEERREQRLKRE 623
Score = 87.4 bits (215), Expect = 4e-17
Identities = 92/309 (29%), Positives = 154/309 (49%), Gaps = 37/309 (11%)
Query: 333 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAK- 391
Q E+++R+ R +R L+ ER+R+ + +EE LL E+R Q EL+R + K
Sbjct: 1028 QEEEQLLREEREKRRLQ---ERERQYREEEELQQEEEQLLGEERETRRRQ-ELERQYRKE 1083
Query: 392 ---QRRE----REEREKQRALEQGRRA-WAAQVEERRGRRGREEREAARRRQRQYERSEE 443
Q+ E REE EK+R E+ R+ ++++ + REERE +RR+++ ER
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE--KRRRQELERQYR 1141
Query: 444 RRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRA 503
E+ + + L RE E+ R++ R+ ++E+ L+Q EE L RE E+ R+ER +
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL--REEQEKRRQERER-- 1197
Query: 504 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQERE-GLRSSLEASLGRAQENY 562
+ R+E +LQR+KR+ +R R E Q E+E +R + GR E +
Sbjct: 1198 ---QYREEEELQRQKRK----QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQF 1250
Query: 563 EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSF---DRMVREAQ 619
R+LE S+ R+ + L+ + +E+ R + R F +++ RE Q
Sbjct: 1251 ------RQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Query: 620 LHAS-LDRK 627
A DRK
Sbjct: 1305 KEAKRRDRK 1313
Score = 86.3 bits (212), Expect = 8e-17
Identities = 84/305 (27%), Positives = 139/305 (45%), Gaps = 26/305 (8%)
Query: 330 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 389
Q Q E+++R+ R +R + ER+R+ + +EE LL E+ Q ++
Sbjct: 935 QLQQEEEQLLREEREKRRRQ---ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 390 AKQRRE-------REEREKQRALE---QGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
++ + REEREK+R E Q R+ Q EE + R E+ + R+RQY
Sbjct: 992 EEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYR 1051
Query: 440 RSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRER 499
EE ++E + LL ER R R++ R+ ++E+ L+Q EE L RE E+ RR+
Sbjct: 1052 EEEELQQE---EEQLLGEERETRR-RQELERQYRKEEELQQEEEQLL--REEPEKRRRQE 1105
Query: 500 AQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQ 559
+R R +E +LQ+E+ +L R ER + Q RQ R+E E ++ E L
Sbjct: 1106 RERQCR----EEEELQQEEEQLLREEREKRRR--QELERQYREEEE-VQQEEEQLLREEP 1158
Query: 560 ENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQ 619
E + R+ E+L +E L + R + + EE + + R+
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218
Query: 620 LHASL 624
+ L
Sbjct: 1219 QRSDL 1223
Score = 81.6 bits (200), Expect = 2e-15
Identities = 78/300 (26%), Positives = 141/300 (47%), Gaps = 32/300 (10%)
Query: 333 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQ 392
Q ER +Q+R E+ LR R++++ R +++L +Q Q++ +Q
Sbjct: 368 QEEERREQQLRREQQLR----REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 423
Query: 393 --RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
RRE+EE ++ EQ RR E+R +R +EER +R+ + ER E+ RR
Sbjct: 424 QLRREQEEERHEQKHEQERR-------EQRLKREQEERRDWLKREEETERHEQERR---- 472
Query: 451 RQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRE--RAEQIRRERAQRAARAKQ 508
+Q L R + ER R +L + ++ + ++RE+ L+ +E R ++++R+ + + +
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL 532
Query: 509 RQEGQLQREKREL-SRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAI 567
R E QL+RE+ E + + E L+ R+QR +RE +E + L
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE------------QEERRDQLLK 580
Query: 568 GRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
+ R ++L RE+ LE +E+ RE+ R R QL S +++
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640
Score = 81.6 bits (200), Expect = 2e-15
Identities = 80/302 (26%), Positives = 142/302 (47%), Gaps = 39/302 (12%)
Query: 340 RQVRAERGLRGV-PERDRKIAA---LMLARHQEELLLLEQ-RAAAHGQWELQRVHAKQR- 393
+Q+R + G + + ERDRK L+ R +++L E+ R + +L+R +Q+
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661
Query: 394 ---REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE----------- 439
R+R+ RE+++ L++G + E R R+ REE + RR++R+ +
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQE--RDRKFREEEQQLRRQERERKFLQEEQQLRRQ 1719
Query: 440 ------RSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
R EE+ R+ E++ L R+ER + E++LR ++EQ L+++E + E E
Sbjct: 1720 ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREE--E 1777
Query: 494 QIRRERAQRAARAKQ-----RQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLR 548
Q+R+ER ++ R+++ R+E QL++E+ E + R + Q +E+E
Sbjct: 1778 QLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQE--- 1834
Query: 549 SSLEASLGRAQENYEHLAIGRKLERSEQ-LTRERRSALESARSTARASFHVREKVREETN 607
L R E A K R EQ L +E R H+R + +EE
Sbjct: 1835 QRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894
Query: 608 TR 609
R
Sbjct: 1895 HR 1896
Score = 79.7 bits (195), Expect = 7e-15
Identities = 78/312 (25%), Positives = 139/312 (44%), Gaps = 30/312 (9%)
Query: 328 SPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQR 387
S Q QH+ ++ E+ R +RDR +E+L EQ+ A + Q
Sbjct: 1263 SQQDLQHLLGEQQERDREQERRRWQQRDRHFP------EEEQLEREEQKEAKRRDRKSQE 1316
Query: 388 VHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
R EREE+ +++ ++ R EE + + REE+ R+ + + R EE R +
Sbjct: 1317 EKQLLREEREEKRRRQETDRKFR------EEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370
Query: 448 LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRER-----AEQIRRERAQR 502
R+ L +R R RE + K +Q+ ++RE+ L++ R+R +Q+ R+ R
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430
Query: 503 AARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENY 562
R +++Q + +RE++ L ++ R E R R+ R+E + L+ E L R + +
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQE-----RHRKFREEEQLLQEREEQQLHRQERDR 1485
Query: 563 EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSF-------DRMV 615
+ L ++L R E+ + R L S + R +++ + R F R
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRS-QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544
Query: 616 REAQLHASLDRK 627
R Q DRK
Sbjct: 1545 RGQQRRQDRDRK 1556
Score = 77.8 bits (190), Expect = 3e-14
Identities = 83/325 (25%), Positives = 144/325 (44%), Gaps = 65/325 (20%)
Query: 351 VPERDRKIAALMLARHQEELLLLEQRAAAHGQW-ELQRVHAKQRREREERE------KQR 403
V R RK + QEE +R + QW E +R H +Q+ E + R+ +
Sbjct: 719 VYSRPRKQEGQRRRQEQEEK---RRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEE 775
Query: 404 ALEQGRRAWAAQ--VEERRGRRGREEREAARRRQR---QYERSEERRRELAERQGLLR-R 457
E+GR+ +A+ + E+R R+ R E E +R QR + E E+RRR+ ER+ L+
Sbjct: 776 KSERGRQRLSARPPLREQRERQLRAE-ERQQREQRFLPEEEEKEQRRRQRREREKELQFL 834
Query: 458 ERAERAAREDRLRKLQQEQN---------------------------------------- 477
E E+ R +R ++LQ+E++
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA 894
Query: 478 ----LKQREEGLQEGRERAEQIRRERAQRAARAKQ-RQEGQLQREKRELSRAERARHEAL 532
L++ ++ LQE E ++ RE+ +R + +Q R+E QLQ+E+ +L R ER +
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR- 953
Query: 533 LQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTA 592
Q R RQ R++++ L+ E LG E +K E+L +E L R
Sbjct: 954 -QERERQYRKDKK-LQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 593 RASFHVREKVREETNTRSFDRMVRE 617
R R+ +++ + ++++RE
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLRE 1036
Score = 77.8 bits (190), Expect = 3e-14
Identities = 82/326 (25%), Positives = 147/326 (45%), Gaps = 34/326 (10%)
Query: 324 DLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQW 383
D + Q + ER +++ A LR +R+R++ A EE EQR +
Sbjct: 766 DFTWQWQAEEKSERGRQRLSARPPLR--EQRERQLRA-------EERQQREQRFLPEEEE 816
Query: 384 ELQRVHAKQRREREER----EKQRALEQGRRAWAAQVEE------RRGRRGREEREAARR 433
+ QR +QRRERE+ E++ L++ RA Q EE + RR +E+R +
Sbjct: 817 KEQR--RRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874
Query: 434 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
R + E + RR L + L + R E+ ++ +LQ+E+ K+R + + E
Sbjct: 875 RWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE 934
Query: 494 QIRRE-----RAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ----ER 544
Q+++E R +R R +Q +E Q +++K+ + E+ E + R RQ+R+ E
Sbjct: 935 QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE-PEKRRRQEREKKYREE 993
Query: 545 EGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
E L+ E L +E R+ + ++L +E L R R R+ E
Sbjct: 994 EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE 1053
Query: 605 ETNTRSFDRMV---REAQLHASLDRK 627
E + ++++ RE + L+R+
Sbjct: 1054 EELQQEEEQLLGEERETRRRQELERQ 1079
Score = 77.4 bits (189), Expect = 4e-14
Identities = 76/262 (29%), Positives = 121/262 (46%), Gaps = 23/262 (8%)
Query: 374 EQRAAAHGQWEL--QRVHAKQRREREEREKQRALEQG-RRAWAAQVEERRGRRGREEREA 430
E+RA G+ L R + +R E R++Q E G RR Q +ER G E+ E
Sbjct: 98 EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE- 156
Query: 431 ARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLR--------KLQQEQNLKQRE 482
+++R +R +RR E RQ +ER ER A E++L+ + E+ L++RE
Sbjct: 157 --KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 483 --EGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540
E ++GRE +Q RRER R + ++ +E R++ + R E + + R R+
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKE---WRKRETVLRKEEEKLQEEEPQRQREL 271
Query: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 600
++E E LR L R ++ E ++L R +QL R++ + R RE
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQ--QRLRREQQLRRKQEEERREQQEERREQQERRE 329
Query: 601 --KVREETNTRSFDRMVREAQL 620
+ R E R RE QL
Sbjct: 330 QQEERREQQLRREQEERREQQL 351
Score = 77.0 bits (188), Expect = 5e-14
Identities = 77/265 (29%), Positives = 123/265 (46%), Gaps = 25/265 (9%)
Query: 325 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
L +T +H Q R ++ L+ E +R+ L L + + + E
Sbjct: 458 LKREEETERH-----EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE 512
Query: 385 LQRVHAKQRREREEREKQR--ALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
+R +R+E EER +QR + +Q RR + E+ R + E RR QR E
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE 572
Query: 443 ERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQR 502
ERR +L +R+ R++R +R +E+RL EQ LK+ E E ER EQ R +R
Sbjct: 573 ERRDQLLKREEERRQQRLKR-EQEERL-----EQRLKREEVERLEQEERREQ----RLKR 622
Query: 503 AARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENY 562
++R++ L+ E++E R ++ R E Q R+QR +RE LE L R
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRRE---QQERREQRLKREEEEERLEQRLKR----- 674
Query: 563 EHLAIGRKLERSEQLTRERRSALES 587
EH R+ E +E+ + R ++S
Sbjct: 675 EHEEERREQELAEEEQEQARERIKS 699
Score = 75.5 bits (184), Expect = 1e-13
Identities = 90/344 (26%), Positives = 147/344 (42%), Gaps = 61/344 (17%)
Query: 333 QHVERIVRQVRAERGL-RGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAK 391
+ VER+ ++ R E+ L R PE +R+ L+ + QEE + R + E QR+ +
Sbjct: 605 EEVERLEQEERREQRLKREEPEEERR-QQLLKSEEQEERRQQQLRREQQERRE-QRLKRE 662
Query: 392 QRREREEREKQRALEQGRRAWAAQVEERRGRRGRE-----------EREAARRRQRQYER 440
+ ER E+ +R E+ RR EE+ R R E EA R+ + Y R
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR 722
Query: 441 ---SEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLK-------QREEGLQEGRE 490
E +RR + + RRE + E+R + QQE+ + Q EE + GR+
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782
Query: 491 R--AEQIRRERAQRAARAKQRQEGQL-------QREKRELSRAERARH------EALLQG 535
R A RE+ +R RA++RQ+ + ++E+R R ER + E LQ
Sbjct: 783 RLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR 842
Query: 536 RTRQQR--QEREGLRSSLEASLGRAQEN-------------------YEHLAIGRKLERS 574
R R Q+ +E +GL+ E + Q Y A+ +L +
Sbjct: 843 RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE 902
Query: 575 EQLTRERRSALE-SARSTARASFHVREKVREETNTRSFDRMVRE 617
+QL +E L+ R R R+ EE + ++++RE
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE 946
Score = 74.7 bits (182), Expect = 2e-13
Identities = 86/313 (27%), Positives = 137/313 (43%), Gaps = 33/313 (10%)
Query: 336 ERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQW---------ELQ 386
ER +Q R E+ LR E R+ + QEE L+QR + Q +L
Sbjct: 495 ERREQQERREQQLRREQEERRE----QRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Query: 387 RVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRR 446
+ ++R E+E RE++ EQ R E R+ R +RE R +++ +R E R
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610
Query: 447 ELAE-RQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAAR 505
E E R+ L+RE E R+ L+ +QE+ +++++ +E +ER EQ R +R + R
Sbjct: 611 EQEERREQRLKREEPEEERRQQLLKSEEQEE--RRQQQLRREQQERREQ-RLKREEEEER 667
Query: 506 AKQRQEGQLQREKRELSRAERARHEALLQGRTR-----QQRQEREGLRSSLEASLGRAQE 560
+QR + + + E+RE AE + +A + ++R Q + R S S R QE
Sbjct: 668 LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727
Query: 561 ----NYEHLAIGRKLERSEQLTRERRSALESARSTARASF-------HVREKVREETNTR 609
E R+ E Q E R+ + R F E+ R+ + R
Sbjct: 728 GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR 787
Query: 610 SFDRMVREAQLHA 622
R RE QL A
Sbjct: 788 PPLREQRERQLRA 800
Score = 70.9 bits (172), Expect = 3e-12
Identities = 91/346 (26%), Positives = 153/346 (44%), Gaps = 64/346 (18%)
Query: 330 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQ---RAAAHGQW--- 383
+ Q E+++R+ +R + + + R+ L + +E+LL EQ R Q+
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQ--QEEEQLLREEQEKRRQERERQYREE 1202
Query: 384 -ELQRVHAKQR-REREER---------EKQRAL------------EQGRRAWAAQVEERR 420
ELQR KQR R+ ++R EK+ A+ EQ R+ +Q+ +R+
Sbjct: 1203 EELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ 1262
Query: 421 ---------GRRGREEREAARRR----------QRQYERSEE-----RRRELAERQGLLR 456
G + +RE RRR + Q ER E+ R R+ E + LLR
Sbjct: 1263 SQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLR 1322
Query: 457 RERAERAAREDRLRKL-QQEQNLKQREEGLQEGRERAEQIRRE--RAQRAARAKQRQEGQ 513
ER E+ R++ RK ++EQ L++REE +ER + R E R Q R +E +
Sbjct: 1323 EEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQR 1382
Query: 514 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
L+R++RE + + + Q R +Q RQ+R+ E L R + + + +++ R
Sbjct: 1383 LRRQERE-RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441
Query: 574 SEQLTRERRSALE--SARSTARASFHVREKVREETNTRSFDRMVRE 617
E RER+ E R F E++ +E + R R+
Sbjct: 1442 QE---RERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERD 1484
Score = 69.3 bits (168), Expect = 1e-11
Identities = 78/266 (29%), Positives = 123/266 (46%), Gaps = 30/266 (11%)
Query: 325 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA--LMLARHQEELLLLEQRAAAHGQ 382
L H E + Q E+ LR ERDRK L R + E L++ Q
Sbjct: 1661 LRHDRDRKFREEEQLLQEGEEQQLRR-QERDRKFREEEQQLRRQERERKFLQEEQQLRRQ 1719
Query: 383 WELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
EL+R ++ + R+E E+++ Q R + +EE + R REE++ R+ + + R E
Sbjct: 1720 -ELERKFREEEQLRQETEQEQLRRQER--YRKILEEEQLRPEREEQQLRRQERDRKFREE 1776
Query: 443 ERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQR---------EEGLQ----EGR 489
E+ R+ E Q L +E + E++LR+ ++EQ L+ + EE LQ E R
Sbjct: 1777 EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQR 1836
Query: 490 ---ERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREG 546
ER Q R E +R+E +L +E+ + R ER R L + R+Q++E +
Sbjct: 1837 LRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERER--KLREEHIRRQQKEEQR 1894
Query: 547 LRSSLEASLGRAQENYEHLAIGRKLE 572
R E ++QE H GR LE
Sbjct: 1895 HRQVGEI---KSQEGKGH---GRLLE 1914
Score = 61.2 bits (147), Expect = 3e-09
Identities = 67/245 (27%), Positives = 100/245 (40%), Gaps = 40/245 (16%)
Query: 417 EERRGR-RGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAR---------- 465
EE+R R G+E RR++ R E R R+L E G RR++ + R
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 466 -----EDRLRKLQQEQNLKQREEGLQEGRERAEQIR------------------RERAQR 502
E R R+ + E+ +QR+E + RAE+ + R R
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELL 216
Query: 503 AARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENY 562
R K R+E Q QR +R+ R + E + R R+E E L+ QE
Sbjct: 217 ELRRKGREEKQQQRRERQ-DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275
Query: 563 EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHA 622
E L RKLER E L RER+ E + R +R K EE + +R ++ +
Sbjct: 276 EQL---RKLERQE-LRRERQEE-EQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330
Query: 623 SLDRK 627
+R+
Sbjct: 331 QEERR 335
Score = 49.7 bits (117), Expect = 8e-06
Identities = 50/190 (26%), Positives = 84/190 (44%), Gaps = 17/190 (8%)
Query: 448 LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
L + GL +RA +E L+ +QE++ ++ E ++ E Q RR++ Q R
Sbjct: 89 LGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQEREL 148
Query: 508 QRQEGQLQREKRELSRAERARHEALLQGRTR-QQRQEREGLRSSLEASLGRAQENY---- 562
E Q ++++R R + R E L + R Q+R+ER L++ G E +
Sbjct: 149 AEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEE 208
Query: 563 -----EHLAIGRK-LERSEQLTRERRSAL---ESARSTARASFHVR---EKVREETNTRS 610
E L + RK E +Q RER+ + E + + +R EK++EE R
Sbjct: 209 QLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268
Query: 611 FDRMVREAQL 620
+ E QL
Sbjct: 269 RELQEEEEQL 278
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 90.5 bits (223), Expect = 4e-18
Identities = 68/211 (32%), Positives = 120/211 (56%), Gaps = 26/211 (12%)
Query: 381 GQWELQRVHAKQRRERE----EREKQRALEQGRRAWAAQVEERRGRRGREEREAA-RRRQ 435
G+ E + K+RRERE EREK+R E+G++ E++G R +EERE RRR+
Sbjct: 51 GKKERESERKKERREREKRKREREKERKRERGKK-------EKKGERKKEERERKKRRRE 103
Query: 436 RQY---ERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERA 492
++ E E+R+++ + +G +E ER +E+R R+ ++E+ K+ E ++ RER
Sbjct: 104 KENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER--EKERERK 161
Query: 493 EQIRRERAQRAARAKQRQEGQ-LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSL 551
E+ +RER Q + ++R+E + +R+KRE +R ER + R R++R+ER+ R
Sbjct: 162 ERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKE------RERKERRERKKERKKK 215
Query: 552 EASLGRAQENYEHLAIGRKLERSEQLTRERR 582
E Q++ + R+ ER ++ +ER+
Sbjct: 216 EERKKERQKDRQ--TNWREKERGKRERKERK 244
Score = 78.2 bits (191), Expect = 2e-14
Identities = 57/210 (27%), Positives = 112/210 (53%), Gaps = 10/210 (4%)
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
R+ E G ER+ + R + + ++R G+ E + K+ RER++R
Sbjct: 41 REREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKR 100
Query: 400 EKQRALEQGRRAWAAQVEER--RGRRGREEREAARRRQRQYERSEERRRELAERQGLLRR 457
+++ ++G + +E+ RGR +E +E R+ +R+ E +ER R+ ER+ R
Sbjct: 101 RREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREK--ER 158
Query: 458 ERAERAAREDR-LRKLQQEQNLKQREEGLQEGRERAEQIR-RERAQRAARAKQRQEGQLQ 515
ER ER RE + + + ++E+ K+R+E + R R E+ + RER +R R K+R++ + +
Sbjct: 159 ERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEER 218
Query: 516 REKRELSRAERARHEALLQGRTRQQRQERE 545
+++R+ R R + R +++R+ER+
Sbjct: 219 KKERQKDRQTNWREKE----RGKRERKERK 244
Score = 77.4 bits (189), Expect = 4e-14
Identities = 68/259 (26%), Positives = 125/259 (48%), Gaps = 38/259 (14%)
Query: 373 LEQRAAAHGQWELQRVHAKQRR--------EREEREKQRALEQGRRAWAAQVEERRG-RR 423
+ RAA ELQ V + E RE++R +E + + ER+ RR
Sbjct: 5 ISSRAAVKLNTELQMVSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERR 64
Query: 424 GREEREAARRRQRQYERSE-----ERRRELAERQGLLRRERAERAAREDRLRKLQQEQNL 478
RE+R+ R ++R+ ER + ER++E ER ++ R E+ +E ++ ++++
Sbjct: 65 EREKRKREREKERKRERGKKEKKGERKKEERER----KKRRREKENKEGEEKEKRKKKEK 120
Query: 479 KQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTR 538
K+R +EG+ER + R+R +R R ++++E + +RE++E + ER + + R
Sbjct: 121 KERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKE 180
Query: 539 QQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHV 598
++R+ER+ + + N + RK ER + RER+ + +
Sbjct: 181 KERKERK-----------KRERNRKE----RKKERERKERRERKKERKKKEERKKE---- 221
Query: 599 REKVREETNTRSFDRMVRE 617
R+K R +TN R +R RE
Sbjct: 222 RQKDR-QTNWREKERGKRE 239
Score = 72.8 bits (177), Expect = 9e-13
Identities = 43/141 (30%), Positives = 81/141 (57%), Gaps = 5/141 (3%)
Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERR-RELA 449
K+ E+E+R+K+ E+GR + + ER+ R REER+ R++ + E+ ER+ R+
Sbjct: 107 KEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKR 166
Query: 450 ERQ--GLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
ER+ G ER E+ +E + R+ +++ K+RE +E RER ++ +++ ++ R K
Sbjct: 167 ERKQVGEKEEERKEKERKERKKRERNRKERKKERER--KERRERKKERKKKEERKKERQK 224
Query: 508 QRQEGQLQREKRELSRAERAR 528
RQ ++E+ + R ER +
Sbjct: 225 DRQTNWREKERGKRERKERKK 245
Score = 39.3 bits (90), Expect = 0.011
Identities = 30/141 (21%), Positives = 60/141 (42%), Gaps = 8/141 (5%)
Query: 487 EGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREG 546
E RER +I + + R +R++ + +REKR+ R + + E + ++E++G
Sbjct: 37 EIREREREIETRKEGKKERESERKKERREREKRKREREKERKRE--------RGKKEKKG 88
Query: 547 LRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREET 606
R E + + E+ K +R ++ +ER + + R RE+ +E
Sbjct: 89 ERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERE 148
Query: 607 NTRSFDRMVREAQLHASLDRK 627
+ RE + +RK
Sbjct: 149 RKKEEREKERERKERKKRERK 169
Score = 30.4 bits (67), Expect = 5.1
Identities = 29/138 (21%), Positives = 56/138 (40%), Gaps = 19/138 (13%)
Query: 317 GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQR 376
GR+ G + + ER R+ + E + ++RK +EE ++R
Sbjct: 124 GRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKER 183
Query: 377 AAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQR 436
+ ++ K+R +E RE+ ++ R+ +EER+ R++ R
Sbjct: 184 KERKKRERNRKERKKERERKERRER-----------------KKERKKKEERKKERQKDR 226
Query: 437 Q--YERSEERRRELAERQ 452
Q + E +RE ER+
Sbjct: 227 QTNWREKERGKRERKERK 244
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 89.7 bits (221), Expect = 7e-18
Identities = 99/373 (26%), Positives = 153/373 (41%), Gaps = 70/373 (18%)
Query: 157 ERRAKLQQCRAERERIMREE--KRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL- 213
E++ K ++ E+ + RE K+R P SP A +A+ A+ +P + + S S S
Sbjct: 416 EKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWH 475
Query: 214 -PASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSY 272
PASP P SP T PP S G + S RR+E A S S A
Sbjct: 476 RPASPCP--------SPGPGHTLPPKPPSPRGTTA-SPKGRVRRKEEAKESPSAAGPEDK 526
Query: 273 SGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTA 332
S R A+ + P+ + S T P + P + P T
Sbjct: 527 SQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTP 586
Query: 333 ----------QHVERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHG 381
+ R++ + R + R R E++R++ A R +EE L E A A
Sbjct: 587 SKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAER 646
Query: 382 QWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERS 441
+ E A++R E+E REK +A E+E R Q+Q E +
Sbjct: 647 EAE-----ARRREEQEAREKAQA----------------------EQEEQERLQKQKEEA 679
Query: 442 EERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQI-RRERA 500
E R RE AERQ +L++E++ +Q+E+ QE R+R E+I +R R
Sbjct: 680 EARSREEAERQ------------------RLEREKHFQQQEQERQERRKRLEEIMKRTRK 721
Query: 501 QRAARAKQRQEGQ 513
+ KQ+Q+ +
Sbjct: 722 SEVSETKQKQDSK 734
Score = 69.7 bits (169), Expect = 8e-12
Identities = 100/390 (25%), Positives = 158/390 (40%), Gaps = 45/390 (11%)
Query: 182 TPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAGS 241
+PL+P + + A A G ++ SPAP R+ SP + +
Sbjct: 368 SPLTPCSVTRSVHRCAPAGERGERRKPNAGG---SPAP-VRRRPEASPVQKKEKKDKERE 423
Query: 242 RTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTT 301
KS S ++ +L + A S+ + L P++ AR S P S++
Sbjct: 424 NEKEKSALARERSLKKRQSLPASPRARLSASTASELS-----PKSKARPSSP----STSW 474
Query: 302 NAPGRPSALTLVPITGRSFSLGDLSHSPQ--TAQHVERIVRQVRAERGLRGVPERDRKIA 359
+ P P P G +L SP+ TA R+ R+ A+ D K
Sbjct: 475 HRPASPC-----PSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPED-KSQ 528
Query: 360 ALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEER 419
+ A +++E A + K++ E A+ A A V
Sbjct: 529 SKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAET-PTDAAVLTSPPAPAPPVTPS 587
Query: 420 RGRRGREEREAA--------RRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRK 471
+ G +RE A R+ + Q ER E+ RR AER +R R E+ ARE R
Sbjct: 588 KPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERD---KRMREEQLAREAEARA 644
Query: 472 LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEA 531
++E ++REE QE RE+A Q +E +R + K+ E + RE+ E R ER +H
Sbjct: 645 -EREAEARRREE--QEAREKA-QAEQEEQERLQKQKEEAEAR-SREEAERQRLEREKH-- 697
Query: 532 LLQGRTRQQRQEREGLRSSLEASLGRAQEN 561
+QQ QER+ R LE + R +++
Sbjct: 698 -----FQQQEQERQERRKRLEEIMKRTRKS 722
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/131 (26%), Positives = 64/131 (48%), Gaps = 2/131 (1%)
Query: 478 LKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRT 537
L ++ +E RER EQ RR +A+R R ++ Q + + E R R E + +
Sbjct: 603 LAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKA 662
Query: 538 RQQRQEREGLRSSLEASLGRAQENYEHLAIGRK--LERSEQLTRERRSALESARSTARAS 595
+ +++E+E L+ E + R++E E + R+ ++ EQ +ERR LE R S
Sbjct: 663 QAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKS 722
Query: 596 FHVREKVREET 606
K ++++
Sbjct: 723 EVSETKQKQDS 733
Score = 43.1 bits (100), Expect = 8e-04
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 6/97 (6%)
Query: 425 REEREAARRRQRQYERSEERRRELAERQGL-LRRERAERAAREDRLRKLQQEQNLKQREE 483
+E ++A R + ER EER + LA ++ + L +E +A RE +L QE+ + E+
Sbjct: 130 QEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQL----QERRRRLEEQ 185
Query: 484 GLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRE 520
L+ + RA R+R Q+ + K+R E +QR ++
Sbjct: 186 RLKAEQRRAALEERQR-QKLEKNKERYEAAIQRSVKK 221
Score = 40.8 bits (94), Expect = 0.004
Identities = 34/121 (28%), Positives = 59/121 (48%), Gaps = 15/121 (12%)
Query: 441 SEERRRELAERQGLLRRERAERA---AREDRLRKLQQEQNLKQREEGLQEGRERAEQIRR 497
+++ ++ ER L + R ERA A + + ++E+ RE+ LQE R R E+ R
Sbjct: 128 TKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187
Query: 498 ERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ----RQEREGLRSSLEA 553
+ QR A ++RQ +L++ K R+EA +Q ++ RQ+R +L
Sbjct: 188 KAEQRRAALEERQRQKLEKNKE--------RYEAAIQRSVKKTWAEIRQQRWSWAGALHH 239
Query: 554 S 554
S
Sbjct: 240 S 240
Score = 38.5 bits (88), Expect = 0.019
Identities = 23/74 (31%), Positives = 37/74 (50%), Gaps = 2/74 (2%)
Query: 389 HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRREL 448
H + REER K A ++ W + E+ + R ++ +E RR + Q ++E+RR L
Sbjct: 139 HKLAKERREERAKYLAAKKA--VWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAAL 196
Query: 449 AERQGLLRRERAER 462
ERQ + ER
Sbjct: 197 EERQRQKLEKNKER 210
Score = 35.0 bits (79), Expect = 0.21
Identities = 53/230 (23%), Positives = 89/230 (38%), Gaps = 23/230 (10%)
Query: 211 ASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSS 270
A P + R + PSP + PPP S + D+ + S +
Sbjct: 11 AGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPP-DTPPAMKNATSSKQLPLEPE 69
Query: 271 SYSGESLRELRWPPRASARNSCPAGSASSTTNAP-------GRPSALTLVPITGRSFSLG 323
S SG+ P A + P+ A S P RP + P S +
Sbjct: 70 SPSGQV-----GPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQP----SPTAV 120
Query: 324 DLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA---LMLARHQEELLLLE-QRAAA 379
S SP T Q V++ + + + R ER + +AA + L + ++ L E Q
Sbjct: 121 PASDSPPTKQEVKKAGERHKLAKERR--EERAKYLAAKKAVWLEKEEKAKALREKQLQER 178
Query: 380 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREERE 429
+ E QR+ A+QRR E +++ LE+ + + A ++ + E R+
Sbjct: 179 RRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQ 228
Score = 32.7 bits (73), Expect = 1.0
Identities = 63/274 (22%), Positives = 98/274 (35%), Gaps = 41/274 (14%)
Query: 39 EAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDC 98
E+ ++ P+ + + AS+ SA+ A P + P ++EQ P
Sbjct: 516 ESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPA---------- 565
Query: 99 PEAEGSRYVLTSPRSLEACARCAVKPV------ELLPRALADLVREAPGRSMRVATGLYE 152
E VLTSP + A KP+ E R LA+ R+A R R E
Sbjct: 566 -ETPTDAAVLTSPPA-PAPPVTPSKPMAGTTDREEATRLLAEKRRQA--REQR------E 615
Query: 153 AYEAERRAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSAS 212
E ERR + AER++ MREE+ A A A A A + +
Sbjct: 616 REEQERRLQ-----AERDKRMREEQ---------LAREAEARAEREAEARRREEQEAREK 661
Query: 213 LPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSY 272
A + + + AR++ R R+ H R+E E +
Sbjct: 662 AQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRK 721
Query: 273 SGES-LRELRWPPRASARNSCPAGSASSTTNAPG 305
S S ++ + A+A S P + +PG
Sbjct: 722 SEVSETKQKQDSKEANANGSSPEPVKAVEARSPG 755
Score = 30.4 bits (67), Expect = 5.1
Identities = 32/112 (28%), Positives = 55/112 (49%), Gaps = 12/112 (10%)
Query: 401 KQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERA 460
KQ + G R A+ ERR R + ++ + EE+ + L E+Q RR R
Sbjct: 129 KQEVKKAGERHKLAK--ERREERAKY----LAAKKAVWLEKEEKAKALREKQLQERRRRL 182
Query: 461 ERAAREDRLRKLQQEQNLKQRE-EGLQEGRERAE-QIRRERAQRAARAKQRQ 510
E E RL+ Q+ L++R+ + L++ +ER E I+R + A +Q++
Sbjct: 183 E----EQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 88.6 bits (218), Expect = 2e-17
Identities = 70/274 (25%), Positives = 123/274 (44%), Gaps = 10/274 (3%)
Query: 333 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQ 392
+H ER R+ ER ER R+ R ++ E+ A + +R +
Sbjct: 204 RHSER-GRERERERETETETERKRQTDR---ERDRQRKTEREREKQAERERASERETERD 259
Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
+ ER++ R ++ ++ Q + +R RR +RE R+R+RQ ER ER R +
Sbjct: 260 KERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRER 319
Query: 453 GLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEG 512
R ER +R R+ ++E+ K++ E RER Q RE ++A R ++R+
Sbjct: 320 ERERERERERQRETERDREKERERKRKRQTE---MDRERNRQTGREGRRQAERERERERE 376
Query: 513 QLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSS---LEASLGRAQENYEHLAIGR 569
+ ++ RE ER R + R RQ ++R+G R + E R E R
Sbjct: 377 RDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGRER 436
Query: 570 KLERSEQLTRERRSALESARSTARASFHVREKVR 603
+ ++ + RER++ ++ R R++ +V R
Sbjct: 437 EKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPR 470
Score = 87.4 bits (215), Expect = 4e-17
Identities = 72/264 (27%), Positives = 118/264 (44%), Gaps = 35/264 (13%)
Query: 380 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQY 438
H + + R ++R+ ER++QR E+ R+ + ER G RGR+ + + R R+RQ
Sbjct: 94 HRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQR 153
Query: 439 ERSEERRREL-AERQGLLRRERAE-------RAAREDRLRKLQQEQNLKQR--EEGLQEG 488
+ +ER R+ ERQ R R + R R +R R+ ++E + R E G +
Sbjct: 154 DAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERE 213
Query: 489 RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLR 548
RER + ER ++ R + RQ + +RE+ + + ERA + + R++ ++R+ R
Sbjct: 214 RERETETETERKRQTDRERDRQR-KTEREREKQAERERASERETERDKERERERDRDRDR 272
Query: 549 SSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNT 608
R+ ER Q R+R+ E R T R RE+ RE
Sbjct: 273 DR------------------RQKERERQTDRKRQRRTERDRETERKRERQRERERERERN 314
Query: 609 RSFDR-----MVREAQLHASLDRK 627
R +R RE Q DR+
Sbjct: 315 RKRERERERERERERQRETERDRE 338
Score = 86.3 bits (212), Expect = 8e-17
Identities = 64/246 (26%), Positives = 116/246 (47%), Gaps = 22/246 (8%)
Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
++R ++ERE++R Q R + + +R RR ++R R R R+ +R E+ RE
Sbjct: 54 RERNRQKERERRREKRQTER----ETDRKRERRREKDRHRKRDRHRERQRDREKERERQT 109
Query: 451 RQGLLRRERAERAAREDRLRKLQQE-QNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 509
+ R+ ER +++R R+ ++E + + R+ Q RER +ER ++ R +QR
Sbjct: 110 DRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQR 169
Query: 510 QEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHL---- 565
Q + ++++RE + + R E R++++E+E + GR +E
Sbjct: 170 QTERNRQKEREREKNRQERRE-------RERQREKENKTEDRHSERGRERERERETETET 222
Query: 566 ----AIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLH 621
R+ +R + RER E R++ R + R+K RE R DR R+ +
Sbjct: 223 ERKRQTDRERDRQRKTEREREKQAERERASERET--ERDKERERERDRDRDRDRRQKERE 280
Query: 622 ASLDRK 627
DRK
Sbjct: 281 RQTDRK 286
Score = 84.0 bits (206), Expect = 4e-16
Identities = 81/307 (26%), Positives = 134/307 (43%), Gaps = 26/307 (8%)
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
R+ +R R +R RK RH+E E+ E R K+R ++ER
Sbjct: 73 RETDRKRERRREKDRHRK-----RDRHRERQRDREKERERQTDRERDRQREKERNRQKER 127
Query: 400 EKQ--RALEQGRRAWAAQVEERRGRRGRE---EREAARRRQRQYERSEERRRELAE-RQG 453
E++ R E+GR ER +R E ER+ R RQRQ ER+ ++ RE + RQ
Sbjct: 128 ERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQE 187
Query: 454 LLRRER------------AERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQ 501
RER +ER +R R+ + E K++ + ++ + + E+ R ++A+
Sbjct: 188 RRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAE 247
Query: 502 RAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQEN 561
R +++ E +RE+ +R R + + +T ++RQ R E R +E
Sbjct: 248 RERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRER 307
Query: 562 YEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMV-REAQL 620
RK ER + RER E+ R R R++ R+ R +R RE +
Sbjct: 308 ERERERNRKRERERERERERERQRETERD--REKERERKRKRQTEMDRERNRQTGREGRR 365
Query: 621 HASLDRK 627
A +R+
Sbjct: 366 QAERERE 372
Score = 83.6 bits (205), Expect = 5e-16
Identities = 79/297 (26%), Positives = 124/297 (41%), Gaps = 25/297 (8%)
Query: 345 ERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRA 404
+R G ER+R+ A + +E E++ + +R K R+ER ERE+QR
Sbjct: 140 DRQTDGQRERERQRDA---EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQRE 196
Query: 405 LEQGRRAWAAQVEERRGRRGRE-------EREAARRRQ----RQYERSEERRRE-LAERQ 452
E + E+R RGRE E E R+RQ R +R ER RE AER+
Sbjct: 197 KEN-------KTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERE 249
Query: 453 GLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEG 512
RE ER +R R ++++ +Q+E Q R+R + R+R R +QR+
Sbjct: 250 RASERE-TERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERE 308
Query: 513 QLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLE 572
+ + R+ R E Q T + R++ + + + R + R+ E
Sbjct: 309 RERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAE 368
Query: 573 RSEQLTRER-RSALESARSTARASFHVREKVREETNTRSFD-RMVREAQLHASLDRK 627
R + RER R + R R+K RE + D + E Q DR+
Sbjct: 369 RERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRE 425
Score = 80.9 bits (198), Expect = 3e-15
Identities = 82/293 (27%), Positives = 125/293 (42%), Gaps = 22/293 (7%)
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
RQ R ER ER R+ RH E E+ + E +R ++R + +
Sbjct: 185 RQERRER------ERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKT 238
Query: 400 EKQRALEQGRRAWAAQVEERRGRRGREEREAARRR-QRQYERSEERRRELAERQGLLRRE 458
E++R +Q R A++ E R + ER+ R R +RQ ER + R +RQ R+
Sbjct: 239 ERERE-KQAERERASERETERDKERERERDRDRDRDRRQKERERQTDR---KRQRRTERD 294
Query: 459 R-AERAAREDRLRKLQQEQNLK-QREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQR 516
R ER R R+ ++E+N K +RE + RER + R+R + R ++RQ +
Sbjct: 295 RETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRE 354
Query: 517 EKRELSR-----AERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKL 571
R+ R AER R + R RQ +ERE + R +E R
Sbjct: 355 RNRQTGREGRRQAERERERE--RERDRQSARERE--ERERDRDRDRQKERERQTEKDRDG 410
Query: 572 ERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASL 624
+R + RER ES R R ++K RE R DR + ++L
Sbjct: 411 QRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTL 463
Score = 53.9 bits (128), Expect = 4e-07
Identities = 43/177 (24%), Positives = 82/177 (46%), Gaps = 8/177 (4%)
Query: 438 YERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRR 497
+ R +E R+GL + + +R R+ ++E+ ++R+ + R+R + +
Sbjct: 26 FSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREK 85
Query: 498 ERAQRAARAKQRQEGQLQREKRELSR-AERARHEALLQGRTRQQRQEREGLRSSLEASLG 556
+R ++ R ++RQ + + +R+ R +R R + + + R++ EREG R + G
Sbjct: 86 DRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDG 145
Query: 557 RAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDR 613
+ + + A + ER Q RER+ E R R REK R+E R R
Sbjct: 146 QRERERQRDA---EKERERQTDRERQRQTERNRQKERE----REKNRQERRERERQR 195
Score = 47.0 bits (110), Expect = 5e-05
Identities = 52/175 (29%), Positives = 77/175 (44%), Gaps = 11/175 (6%)
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQR-REREE 398
RQ ER ER RK M R + E R A + E +R +Q REREE
Sbjct: 329 RQRETERDREKERERKRKRQTEM-DRERNRQTGREGRRQAERERERERERDRQSAREREE 387
Query: 399 REKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRRELA-ERQGLLR 456
RE+ R ++ + ER+ + R+ +RE ++R+R+ +R ER RE ER+
Sbjct: 388 RERDRDRDRQKE------RERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKG 441
Query: 457 RERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQE 511
RER +R + DR Q++++ + R Q R R R K E
Sbjct: 442 RER-DRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPE 495
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 88.6 bits (218), Expect = 2e-17
Identities = 124/514 (24%), Positives = 212/514 (41%), Gaps = 64/514 (12%)
Query: 104 SRYVLTSPRSLEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQ 163
S VL SL A V+ R LA E P S R+ Y ER ++
Sbjct: 314 SPQVLAQKYSLVAKQESVVRRAS---RRLAKKTAEEPAASGRIICHSY----LERLLNVE 366
Query: 164 QCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAAR 223
+++ E+K P A AAA P ++S P + A
Sbjct: 367 V----PQKVGSEQKE------PPEEAEPVAAAEPEVPENNGNNSW-----PHNDTEIANS 411
Query: 224 KASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLR---EL 280
+P P+++ + P AG + K+ D + A S + S E E
Sbjct: 412 TPNPKPAASSPETPSAGQQEA-KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEE 470
Query: 281 RWPPRASARNS-CPAGSASSTTNA---PGRPSALTLVPITG-----RSFSLGD----LSH 327
PPR+ +S CPA + + + + P + +SF + +
Sbjct: 471 LQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDP 530
Query: 328 SPQTAQHVERIVRQVRAERGLRGVPERD--RKIAALMLARHQEELLLLEQRAAAHGQWEL 385
+ Q +E + R+ AE+ R E D R++ + L R + +L+ R E
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
Query: 386 QRVHAKQR------REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
++ +Q+ + + +E++ A E+ ++ AA+ E R ++E EA R R Q E
Sbjct: 591 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 650
Query: 440 RSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRE--RAEQIRR 497
E R +EL +++ +ER +AA RL + Q+EQ +++E QE RE R EQ RR
Sbjct: 651 EEERRHQELLQKKKEEEQERLRKAAEAKRLAE-QREQERREQERREQERREQERREQERR 709
Query: 498 ERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGR 557
E+ ++ A ++R+E + + +REL E+A R ++E L+ LE +
Sbjct: 710 EQERQLAEQERRREQERLQAERELQEREKA------------LRLQKEQLQRELEEK--K 755
Query: 558 AQENYEHLAIGRKLERSEQLTRERRSALESARST 591
+E + LA + E E+ +E A ++ T
Sbjct: 756 KKEEQQRLAERQLQEEQEKKAKEAAGASKALNVT 789
Score = 73.9 bits (180), Expect = 4e-13
Identities = 68/246 (27%), Positives = 121/246 (49%), Gaps = 29/246 (11%)
Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
R + +E+E+QR R+ A Q+ RR + E + RR + + EER R++
Sbjct: 527 RMDPKEKERQRLENLRRKEEAEQL-----RRQKVEEDKRRRLEEVKLKREERLRKV---- 577
Query: 453 GLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEG 512
L RER E+ E +K Q EQ Q +E ++ +E E++ E+A++ A AK+ +E
Sbjct: 578 -LQARERVEQMKEE---KKKQIEQKFAQIDEKTEKAKE--ERLAEEKAKKKAAAKKMEEV 631
Query: 513 QLQREKRELSRA--------ERARHEALLQGRTRQQRQEREGLRSSLEAS-LGRAQENYE 563
+ +R++ E +R E RH+ LLQ +++ +E+E LR + EA L +E
Sbjct: 632 EARRKQEEEARRLRWLQQEEEERRHQELLQ---KKKEEEQERLRKAAEAKRLAEQREQER 688
Query: 564 HLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVR--EAQLH 621
R+ ER EQ RE+ + + + +E+++ E + ++ +R + QL
Sbjct: 689 REQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQ 748
Query: 622 ASLDRK 627
L+ K
Sbjct: 749 RELEEK 754
Score = 73.9 bits (180), Expect = 4e-13
Identities = 65/261 (24%), Positives = 121/261 (46%), Gaps = 47/261 (18%)
Query: 384 ELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARR-RQRQYERSE 442
E QR+ +R+E E+ +++ +E+ +R +V+ +R R R+ +A R Q + E+ +
Sbjct: 534 ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKK 593
Query: 443 ERRRELAERQGLLRRERAERAARED------------------------RLRKLQQEQNL 478
+ ++ A+ + + ER A E RLR LQQE+
Sbjct: 594 QIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE 653
Query: 479 KQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTR 538
++ +E LQ+ +E ++ R+ A+ A+QR++ + ++E+RE R E+ R E Q R
Sbjct: 654 RRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE---QERRE 710
Query: 539 QQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHV 598
Q+RQ E R + E L R+L+ E+ R ++ L+ +
Sbjct: 711 QERQLAEQER----------RREQERLQAERELQEREKALRLQKEQLQR---------EL 751
Query: 599 REKVREETNTRSFDRMVREAQ 619
EK ++E R +R ++E Q
Sbjct: 752 EEKKKKEEQQRLAERQLQEEQ 772
Score = 45.4 bits (106), Expect = 2e-04
Identities = 94/478 (19%), Positives = 176/478 (36%), Gaps = 46/478 (9%)
Query: 167 AERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLP-ASPAPRAARKA 225
++ E ++ K R+ ++ ++ A G+ S S + SP PR +
Sbjct: 214 SDEESTPKKSKARILESIT-VSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAF 272
Query: 226 SPSPSSARTQPP--------PAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESL 277
SP R P P GSRT +S ++ + S + A S +
Sbjct: 273 PDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIA---PSSPSPQVLAQKYSLVAKQE 329
Query: 278 RELRWPPRASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVER 337
+R R A+ + +AS L V + + S + P+ A+ V
Sbjct: 330 SVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGS--EQKEPPEEAEPVAA 387
Query: 338 IVRQVRAERGLRGVPERDRKIAALML----ARHQEELLLLEQRAAAHGQWELQRVHAKQ- 392
+V G P D +IA A E Q+ A Q + R +
Sbjct: 388 AEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSA 447
Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR--RRQRQYERSEERRRELAE 450
RR+R ++ L++ + +++ R + A++ R R + + +R
Sbjct: 448 RRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRN----- 502
Query: 451 RQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRR-ERAQRAARAKQR 509
Q L+ A R+ + +++ N R + ++ R+R E +RR E A++ R K
Sbjct: 503 -QMLMTPTSAPRSVMKSFIKR-----NTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVE 556
Query: 510 QEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGR 569
++ + + E+ +L R ER R + R Q ++E+ + Q + I
Sbjct: 557 EDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK------------KKQIEQKFAQIDE 604
Query: 570 KLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
K E++++ A + A + R K EE + + E + H L +K
Sbjct: 605 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 662
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 87.0 bits (214), Expect = 5e-17
Identities = 125/518 (24%), Positives = 212/518 (40%), Gaps = 68/518 (13%)
Query: 104 SRYVLTSPRSLEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQ 163
S VL SL A V+ R LA E P S R+ Y ER ++
Sbjct: 314 SPQVLAQKYSLVAKQESVVRRAS---RRLAKKTAEEPAASGRIICHSY----LERLLNVE 366
Query: 164 QCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAAR 223
+++ E+K P A AAA P ++S P + A
Sbjct: 367 V----PQKVGSEQKE------PPEEAEPVAAAEPEVPENNGNNSW-----PHNDTEIANS 411
Query: 224 KASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLR---EL 280
+P P+++ + P AG + K+ D + A S + S E E
Sbjct: 412 TPNPKPAASSPETPSAGQQEA-KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEE 470
Query: 281 RWPPRASARNS-CPAGSASSTTNA---PGRPSALTLVPITG-----RSFSLGDL------ 325
PPR+ +S CPA + + + + P + +SF +
Sbjct: 471 LQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDP 530
Query: 326 --SHSPQTAQHVERIVRQVRAERGLRGVPERD--RKIAALMLARHQEELLLLEQRAAAHG 381
S + Q +E + R+ AE+ R E D R++ + L R + +L+ R
Sbjct: 531 KCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQ 590
Query: 382 QWELQRVHAKQR------REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQ 435
E ++ +Q+ + + +E++ A E+ ++ AA+ E R ++E EA R R
Sbjct: 591 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 650
Query: 436 RQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRE--RAE 493
Q E E R +EL +++ +ER +AA RL + Q+EQ +++E QE RE R E
Sbjct: 651 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAE-QREQERREQERREQERREQERRE 709
Query: 494 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
Q RRE+ ++ A ++R+E + + +REL E+A R ++E L+ LE
Sbjct: 710 QERREQERQLAEQERRREQERLQAERELQEREKA------------LRLQKEQLQRELEE 757
Query: 554 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARST 591
+ +E + LA + E E+ +E A ++ T
Sbjct: 758 K--KKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVT 793
Score = 73.9 bits (180), Expect = 4e-13
Identities = 65/261 (24%), Positives = 121/261 (46%), Gaps = 47/261 (18%)
Query: 384 ELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARR-RQRQYERSE 442
E QR+ +R+E E+ +++ +E+ +R +V+ +R R R+ +A R Q + E+ +
Sbjct: 538 ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKK 597
Query: 443 ERRRELAERQGLLRRERAERAARED------------------------RLRKLQQEQNL 478
+ ++ A+ + + ER A E RLR LQQE+
Sbjct: 598 QIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE 657
Query: 479 KQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTR 538
++ +E LQ+ +E ++ R+ A+ A+QR++ + ++E+RE R E+ R E Q R
Sbjct: 658 RRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE---QERRE 714
Query: 539 QQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHV 598
Q+RQ E R + E L R+L+ E+ R ++ L+ +
Sbjct: 715 QERQLAEQER----------RREQERLQAERELQEREKALRLQKEQLQR---------EL 755
Query: 599 REKVREETNTRSFDRMVREAQ 619
EK ++E R +R ++E Q
Sbjct: 756 EEKKKKEEQQRLAERQLQEEQ 776
Score = 72.0 bits (175), Expect = 2e-12
Identities = 67/241 (27%), Positives = 118/241 (48%), Gaps = 29/241 (12%)
Query: 398 EREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRR 457
E+E+QR R+ A Q+ RR + E + RR + + EER R++ L R
Sbjct: 536 EKERQRLENLRRKEEAEQL-----RRQKVEEDKRRRLEEVKLKREERLRKV-----LQAR 585
Query: 458 ERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQRE 517
ER E+ E +K Q EQ Q +E ++ +E E++ E+A++ A AK+ +E + +R+
Sbjct: 586 ERVEQMKEE---KKKQIEQKFAQIDEKTEKAKE--ERLAEEKAKKKAAAKKMEEVEARRK 640
Query: 518 KRELSRA--------ERARHEALLQGRTRQQRQEREGLRSSLEAS-LGRAQENYEHLAIG 568
+ E +R E RH+ LLQ +++ +E+E LR + EA L +E
Sbjct: 641 QEEEARRLRWLQQEEEERRHQELLQ---KKKEEEQERLRKAAEAKRLAEQREQERREQER 697
Query: 569 RKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVR--EAQLHASLDR 626
R+ ER EQ RE+ + + + +E+++ E + ++ +R + QL L+
Sbjct: 698 REQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 757
Query: 627 K 627
K
Sbjct: 758 K 758
Score = 42.7 bits (99), Expect = 0.001
Identities = 93/478 (19%), Positives = 172/478 (35%), Gaps = 42/478 (8%)
Query: 167 AERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLP-ASPAPRAARKA 225
++ E ++ K R+ ++ ++ A G+ S S + SP PR +
Sbjct: 214 SDEESTPKKSKARILESIT-VSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAF 272
Query: 226 SPSPSSARTQPP--------PAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESL 277
SP R P P GSRT +S ++ + S + A S +
Sbjct: 273 PDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIA---PSSPSPQVLAQKYSLVAKQE 329
Query: 278 RELRWPPRASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVER 337
+R R A+ + +AS L V + + S + P+ A+ V
Sbjct: 330 SVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGS--EQKEPPEEAEPVAA 387
Query: 338 IVRQVRAERGLRGVPERDRKIAALML----ARHQEELLLLEQRAAAHGQWELQRVHAKQ- 392
+V G P D +IA A E Q+ A Q + R +
Sbjct: 388 AEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSA 447
Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR--RRQRQYERSEERRRELAE 450
RR+R ++ L++ + +++ R + A++ R R + + +R + L
Sbjct: 448 RRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMT 507
Query: 451 RQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRR-ERAQRAARAKQR 509
R R LR + + +++ R+R E +RR E A++ R K
Sbjct: 508 PTSAPRSVMKSFIKRNTPLR-------MDPKCSFVEKERQRLENLRRKEEAEQLRRQKVE 560
Query: 510 QEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGR 569
++ + + E+ +L R ER R + R Q ++E+ + Q + I
Sbjct: 561 EDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK------------KKQIEQKFAQIDE 608
Query: 570 KLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
K E++++ A + A + R K EE + + E + H L +K
Sbjct: 609 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 666
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 86.3 bits (212), Expect = 8e-17
Identities = 78/244 (31%), Positives = 119/244 (48%), Gaps = 31/244 (12%)
Query: 368 EELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRAL-EQGRRAWAAQVEERRGRRGRE 426
E+L LE+ AA + E + + +RE EER++Q L Q Q EE R RR E
Sbjct: 718 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 777
Query: 427 E-----REAARRRQRQYERSEERRRELAERQGL---------LRRERAERAAREDRLRKL 472
E +E A RRQR+ E + R+RE ERQ RRE ER +E+ LRK
Sbjct: 778 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 837
Query: 473 QQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQRE-----KRELSRAERA 527
++E REE +E + R E+ R + AAR + +E + ++E ++EL R +
Sbjct: 838 EEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 895
Query: 528 RHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-------HLAIGRKL--ERSEQLT 578
+ EAL + + +QQ+Q+ ++ ++ G+ LA +KL ER QL
Sbjct: 896 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 955
Query: 579 RERR 582
E+R
Sbjct: 956 EEQR 959
Score = 74.3 bits (181), Expect = 3e-13
Identities = 77/280 (27%), Positives = 127/280 (45%), Gaps = 20/280 (7%)
Query: 333 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQE-ELLLLEQRAAAHGQWELQRVHA- 390
Q E + RQ ER R E R+ L R +E E+ L QR Q + + +
Sbjct: 758 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 817
Query: 391 -KQRREREEREKQRAL----EQGRRAWAAQVEERRGR----RGREEREAARRRQRQYERS 441
++RRE EER KQ L E+ WA + EE + R R R E EAAR R +E
Sbjct: 818 EERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR---HEEE 874
Query: 442 EERRREL-AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERA 500
E +R+EL +RQ L R+R ++ RL++ QQ+Q L Q + L +Q
Sbjct: 875 ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK--LPSSSTWGQQSNTTAC 932
Query: 501 QRAARAKQRQEGQLQREK-RELSRAERARHEALLQGRTRQQRQEREGLR--SSLEASLGR 557
Q A + +L+ E+ R+L +R + L++ +QQ+Q+++ L ++ G
Sbjct: 933 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 992
Query: 558 AQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 597
+ E + + +Q +++ AR+ ++ H
Sbjct: 993 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1032
Score = 72.4 bits (176), Expect = 1e-12
Identities = 69/249 (27%), Positives = 120/249 (48%), Gaps = 25/249 (10%)
Query: 390 AKQRREREEREKQRALEQGR-----RAWAAQVEERRGRRGREEREAARRRQRQYERSEER 444
A ++ ++ E+ K LEQ R RA + E +R R ++E RRQ++ ER
Sbjct: 716 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 775
Query: 445 RRELAER--QGLLRRER----AERAAREDRLRKLQQE--QNLKQREEGLQEGRERAEQIR 496
ELA R + LRR+R A R RE+ R+ Q+E + L++R +E R++ E +R
Sbjct: 776 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 835
Query: 497 RERAQRAARAKQRQEGQLQREKREL---SRAERARHEALLQGRTRQQRQEREGL---RSS 550
++ + A A++ +E Q + E+ L A R RHE + R + Q ++ L R
Sbjct: 836 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 895
Query: 551 LEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRS 610
+ +L R Q+ + + +++ T ++S + +S A S +K+ EE
Sbjct: 896 QQEALRRLQQQQQQQQLA-QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER---- 950
Query: 611 FDRMVREAQ 619
+R +RE Q
Sbjct: 951 -ERQLREEQ 958
Score = 44.3 bits (103), Expect = 3e-04
Identities = 50/235 (21%), Positives = 108/235 (45%), Gaps = 11/235 (4%)
Query: 330 QTAQHVERIVRQVRAERGLRGVPE--RDRKIAALMLARHQEELLLLEQRAAAHGQWELQR 387
Q + + R+ + R E R E R ++ A AR +EE + + E R
Sbjct: 809 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 868
Query: 388 V-HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYER-SEERR 445
+ H ++ R+R+E E QR E R+ Q RR ++ +++++ A+ + ++
Sbjct: 869 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 928
Query: 446 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE--EGLQEGRERAEQIRRERAQRA 503
+ Q L ++ E+R R+L++EQ +QRE + LQ+ +++ +Q +
Sbjct: 929 TTACQSQATLSLAEIQK-LEEERERQLREEQRRQQRELMKALQQQQQQQQQ-KLSGWGNV 986
Query: 504 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRA 558
++ + L+ ++ E + ++ + + Q + +Q + R S+L S+G +
Sbjct: 987 SKPSGTTKSLLEIQQEEARQMQKQQQQ---QQQHQQPNRARNNTHSNLHTSIGNS 1038
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 86.3 bits (212), Expect = 8e-17
Identities = 78/244 (31%), Positives = 119/244 (48%), Gaps = 31/244 (12%)
Query: 368 EELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRAL-EQGRRAWAAQVEERRGRRGRE 426
E+L LE+ AA + E + + +RE EER++Q L Q Q EE R RR E
Sbjct: 745 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 804
Query: 427 E-----REAARRRQRQYERSEERRRELAERQGL---------LRRERAERAAREDRLRKL 472
E +E A RRQR+ E + R+RE ERQ RRE ER +E+ LRK
Sbjct: 805 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 864
Query: 473 QQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQRE-----KRELSRAERA 527
++E REE +E + R E+ R + AAR + +E + ++E ++EL R +
Sbjct: 865 EEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 922
Query: 528 RHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-------HLAIGRKL--ERSEQLT 578
+ EAL + + +QQ+Q+ ++ ++ G+ LA +KL ER QL
Sbjct: 923 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 982
Query: 579 RERR 582
E+R
Sbjct: 983 EEQR 986
Score = 74.3 bits (181), Expect = 3e-13
Identities = 77/280 (27%), Positives = 127/280 (45%), Gaps = 20/280 (7%)
Query: 333 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQE-ELLLLEQRAAAHGQWELQRVHA- 390
Q E + RQ ER R E R+ L R +E E+ L QR Q + + +
Sbjct: 785 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 844
Query: 391 -KQRREREEREKQRAL----EQGRRAWAAQVEERRGR----RGREEREAARRRQRQYERS 441
++RRE EER KQ L E+ WA + EE + R R R E EAAR R +E
Sbjct: 845 EERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR---HEEE 901
Query: 442 EERRREL-AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERA 500
E +R+EL +RQ L R+R ++ RL++ QQ+Q L Q + L +Q
Sbjct: 902 ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK--LPSSSTWGQQSNTTAC 959
Query: 501 QRAARAKQRQEGQLQREK-RELSRAERARHEALLQGRTRQQRQEREGLR--SSLEASLGR 557
Q A + +L+ E+ R+L +R + L++ +QQ+Q+++ L ++ G
Sbjct: 960 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 1019
Query: 558 AQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 597
+ E + + +Q +++ AR+ ++ H
Sbjct: 1020 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1059
Score = 72.4 bits (176), Expect = 1e-12
Identities = 69/249 (27%), Positives = 120/249 (48%), Gaps = 25/249 (10%)
Query: 390 AKQRREREEREKQRALEQGR-----RAWAAQVEERRGRRGREEREAARRRQRQYERSEER 444
A ++ ++ E+ K LEQ R RA + E +R R ++E RRQ++ ER
Sbjct: 743 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 802
Query: 445 RRELAER--QGLLRRER----AERAAREDRLRKLQQE--QNLKQREEGLQEGRERAEQIR 496
ELA R + LRR+R A R RE+ R+ Q+E + L++R +E R++ E +R
Sbjct: 803 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 862
Query: 497 RERAQRAARAKQRQEGQLQREKREL---SRAERARHEALLQGRTRQQRQEREGL---RSS 550
++ + A A++ +E Q + E+ L A R RHE + R + Q ++ L R
Sbjct: 863 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 922
Query: 551 LEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRS 610
+ +L R Q+ + + +++ T ++S + +S A S +K+ EE
Sbjct: 923 QQEALRRLQQQQQQQQLA-QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER---- 977
Query: 611 FDRMVREAQ 619
+R +RE Q
Sbjct: 978 -ERQLREEQ 985
Score = 44.3 bits (103), Expect = 3e-04
Identities = 50/235 (21%), Positives = 108/235 (45%), Gaps = 11/235 (4%)
Query: 330 QTAQHVERIVRQVRAERGLRGVPE--RDRKIAALMLARHQEELLLLEQRAAAHGQWELQR 387
Q + + R+ + R E R E R ++ A AR +EE + + E R
Sbjct: 836 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 895
Query: 388 V-HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYER-SEERR 445
+ H ++ R+R+E E QR E R+ Q RR ++ +++++ A+ + ++
Sbjct: 896 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 955
Query: 446 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE--EGLQEGRERAEQIRRERAQRA 503
+ Q L ++ E+R R+L++EQ +QRE + LQ+ +++ +Q +
Sbjct: 956 TTACQSQATLSLAEIQK-LEEERERQLREEQRRQQRELMKALQQQQQQQQQ-KLSGWGNV 1013
Query: 504 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRA 558
++ + L+ ++ E + ++ + + Q + +Q + R S+L S+G +
Sbjct: 1014 SKPSGTTKSLLEIQQEEARQMQKQQQQ---QQQHQQPNRARNNTHSNLHTSIGNS 1065
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 86.3 bits (212), Expect = 8e-17
Identities = 78/244 (31%), Positives = 119/244 (48%), Gaps = 31/244 (12%)
Query: 368 EELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRAL-EQGRRAWAAQVEERRGRRGRE 426
E+L LE+ AA + E + + +RE EER++Q L Q Q EE R RR E
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 783
Query: 427 E-----REAARRRQRQYERSEERRRELAERQGL---------LRRERAERAAREDRLRKL 472
E +E A RRQR+ E + R+RE ERQ RRE ER +E+ LRK
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 843
Query: 473 QQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQRE-----KRELSRAERA 527
++E REE +E + R E+ R + AAR + +E + ++E ++EL R +
Sbjct: 844 EEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901
Query: 528 RHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-------HLAIGRKL--ERSEQLT 578
+ EAL + + +QQ+Q+ ++ ++ G+ LA +KL ER QL
Sbjct: 902 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 961
Query: 579 RERR 582
E+R
Sbjct: 962 EEQR 965
Score = 74.3 bits (181), Expect = 3e-13
Identities = 77/280 (27%), Positives = 127/280 (45%), Gaps = 20/280 (7%)
Query: 333 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQE-ELLLLEQRAAAHGQWELQRVHA- 390
Q E + RQ ER R E R+ L R +E E+ L QR Q + + +
Sbjct: 764 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 823
Query: 391 -KQRREREEREKQRAL----EQGRRAWAAQVEERRGR----RGREEREAARRRQRQYERS 441
++RRE EER KQ L E+ WA + EE + R R R E EAAR R +E
Sbjct: 824 EERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR---HEEE 880
Query: 442 EERRREL-AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERA 500
E +R+EL +RQ L R+R ++ RL++ QQ+Q L Q + L +Q
Sbjct: 881 ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK--LPSSSTWGQQSNTTAC 938
Query: 501 QRAARAKQRQEGQLQREK-RELSRAERARHEALLQGRTRQQRQEREGLR--SSLEASLGR 557
Q A + +L+ E+ R+L +R + L++ +QQ+Q+++ L ++ G
Sbjct: 939 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 998
Query: 558 AQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 597
+ E + + +Q +++ AR+ ++ H
Sbjct: 999 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1038
Score = 72.4 bits (176), Expect = 1e-12
Identities = 69/249 (27%), Positives = 120/249 (48%), Gaps = 25/249 (10%)
Query: 390 AKQRREREEREKQRALEQGR-----RAWAAQVEERRGRRGREEREAARRRQRQYERSEER 444
A ++ ++ E+ K LEQ R RA + E +R R ++E RRQ++ ER
Sbjct: 722 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 781
Query: 445 RRELAER--QGLLRRER----AERAAREDRLRKLQQE--QNLKQREEGLQEGRERAEQIR 496
ELA R + LRR+R A R RE+ R+ Q+E + L++R +E R++ E +R
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 841
Query: 497 RERAQRAARAKQRQEGQLQREKREL---SRAERARHEALLQGRTRQQRQEREGL---RSS 550
++ + A A++ +E Q + E+ L A R RHE + R + Q ++ L R
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901
Query: 551 LEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRS 610
+ +L R Q+ + + +++ T ++S + +S A S +K+ EE
Sbjct: 902 QQEALRRLQQQQQQQQLA-QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER---- 956
Query: 611 FDRMVREAQ 619
+R +RE Q
Sbjct: 957 -ERQLREEQ 964
Score = 44.3 bits (103), Expect = 3e-04
Identities = 50/235 (21%), Positives = 108/235 (45%), Gaps = 11/235 (4%)
Query: 330 QTAQHVERIVRQVRAERGLRGVPE--RDRKIAALMLARHQEELLLLEQRAAAHGQWELQR 387
Q + + R+ + R E R E R ++ A AR +EE + + E R
Sbjct: 815 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 874
Query: 388 V-HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYER-SEERR 445
+ H ++ R+R+E E QR E R+ Q RR ++ +++++ A+ + ++
Sbjct: 875 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 934
Query: 446 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE--EGLQEGRERAEQIRRERAQRA 503
+ Q L ++ E+R R+L++EQ +QRE + LQ+ +++ +Q +
Sbjct: 935 TTACQSQATLSLAEIQK-LEEERERQLREEQRRQQRELMKALQQQQQQQQQ-KLSGWGNV 992
Query: 504 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRA 558
++ + L+ ++ E + ++ + + Q + +Q + R S+L S+G +
Sbjct: 993 SKPSGTTKSLLEIQQEEARQMQKQQQQ---QQQHQQPNRARNNTHSNLHTSIGNS 1044
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 86.3 bits (212), Expect = 8e-17
Identities = 78/244 (31%), Positives = 119/244 (48%), Gaps = 31/244 (12%)
Query: 368 EELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRAL-EQGRRAWAAQVEERRGRRGRE 426
E+L LE+ AA + E + + +RE EER++Q L Q Q EE R RR E
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 783
Query: 427 E-----REAARRRQRQYERSEERRRELAERQGL---------LRRERAERAAREDRLRKL 472
E +E A RRQR+ E + R+RE ERQ RRE ER +E+ LRK
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 843
Query: 473 QQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQRE-----KRELSRAERA 527
++E REE +E + R E+ R + AAR + +E + ++E ++EL R +
Sbjct: 844 EEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901
Query: 528 RHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-------HLAIGRKL--ERSEQLT 578
+ EAL + + +QQ+Q+ ++ ++ G+ LA +KL ER QL
Sbjct: 902 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 961
Query: 579 RERR 582
E+R
Sbjct: 962 EEQR 965
Score = 74.3 bits (181), Expect = 3e-13
Identities = 77/280 (27%), Positives = 127/280 (45%), Gaps = 20/280 (7%)
Query: 333 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQE-ELLLLEQRAAAHGQWELQRVHA- 390
Q E + RQ ER R E R+ L R +E E+ L QR Q + + +
Sbjct: 764 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 823
Query: 391 -KQRREREEREKQRAL----EQGRRAWAAQVEERRGR----RGREEREAARRRQRQYERS 441
++RRE EER KQ L E+ WA + EE + R R R E EAAR R +E
Sbjct: 824 EERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR---HEEE 880
Query: 442 EERRREL-AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERA 500
E +R+EL +RQ L R+R ++ RL++ QQ+Q L Q + L +Q
Sbjct: 881 ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK--LPSSSTWGQQSNTTAC 938
Query: 501 QRAARAKQRQEGQLQREK-RELSRAERARHEALLQGRTRQQRQEREGLR--SSLEASLGR 557
Q A + +L+ E+ R+L +R + L++ +QQ+Q+++ L ++ G
Sbjct: 939 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 998
Query: 558 AQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 597
+ E + + +Q +++ AR+ ++ H
Sbjct: 999 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1038
Score = 72.4 bits (176), Expect = 1e-12
Identities = 69/249 (27%), Positives = 120/249 (48%), Gaps = 25/249 (10%)
Query: 390 AKQRREREEREKQRALEQGR-----RAWAAQVEERRGRRGREEREAARRRQRQYERSEER 444
A ++ ++ E+ K LEQ R RA + E +R R ++E RRQ++ ER
Sbjct: 722 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 781
Query: 445 RRELAER--QGLLRRER----AERAAREDRLRKLQQE--QNLKQREEGLQEGRERAEQIR 496
ELA R + LRR+R A R RE+ R+ Q+E + L++R +E R++ E +R
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 841
Query: 497 RERAQRAARAKQRQEGQLQREKREL---SRAERARHEALLQGRTRQQRQEREGL---RSS 550
++ + A A++ +E Q + E+ L A R RHE + R + Q ++ L R
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901
Query: 551 LEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRS 610
+ +L R Q+ + + +++ T ++S + +S A S +K+ EE
Sbjct: 902 QQEALRRLQQQQQQQQLA-QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER---- 956
Query: 611 FDRMVREAQ 619
+R +RE Q
Sbjct: 957 -ERQLREEQ 964
Score = 44.3 bits (103), Expect = 3e-04
Identities = 50/235 (21%), Positives = 108/235 (45%), Gaps = 11/235 (4%)
Query: 330 QTAQHVERIVRQVRAERGLRGVPE--RDRKIAALMLARHQEELLLLEQRAAAHGQWELQR 387
Q + + R+ + R E R E R ++ A AR +EE + + E R
Sbjct: 815 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 874
Query: 388 V-HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYER-SEERR 445
+ H ++ R+R+E E QR E R+ Q RR ++ +++++ A+ + ++
Sbjct: 875 LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 934
Query: 446 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE--EGLQEGRERAEQIRRERAQRA 503
+ Q L ++ E+R R+L++EQ +QRE + LQ+ +++ +Q +
Sbjct: 935 TTACQSQATLSLAEIQK-LEEERERQLREEQRRQQRELMKALQQQQQQQQQ-KLSGWGNV 992
Query: 504 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRA 558
++ + L+ ++ E + ++ + + Q + +Q + R S+L S+G +
Sbjct: 993 SKPSGTTKSLLEIQQEEARQMQKQQQQ---QQQHQQPNRARNNTHSNLHTSIGNS 1044
>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
Length = 202
Score = 80.9 bits (198), Expect = 3e-15
Identities = 55/178 (30%), Positives = 93/178 (52%), Gaps = 5/178 (2%)
Query: 384 ELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEE 443
E +R ++R + ERE + R Q + + R ++ER+ R+R+R+ ER E
Sbjct: 18 ERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQRQRERETERETE 77
Query: 444 RRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRA 503
R+RE ++ R+ ER DR RK + ++N RE + GRER +Q RER +
Sbjct: 78 RQRERQRQRERKRQTDRERDKDRDRERKRETDRN---RERNRKGGRERDKQTERERDRER 134
Query: 504 ARAKQRQ-EGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQE 560
R +QR+ E Q QRE++ + ER R A + R +++++ER+ R + R ++
Sbjct: 135 ERQRQRERERQRQRERKRETDRERQRW-AEREERKKERKKERKKERKEKKKEEKRRED 191
Score = 72.8 bits (177), Expect = 9e-13
Identities = 61/208 (29%), Positives = 99/208 (47%), Gaps = 18/208 (8%)
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
R+ +RG ERDR+ R +E E R H Q + R +Q +ER
Sbjct: 7 RKRETDRGKETERERDRQ-------RERENQTERENR---HRQRDRHRERDRQTDREKER 56
Query: 400 EKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRRELAERQGLLRRE 458
E+Q+ E+ R+ + ER R RE +R+ R+RQ ER ++R RE +R+ RE
Sbjct: 57 ERQK--ERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRE-RKRETDRNRE 113
Query: 459 RAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREK 518
R + RE + +Q + + RE Q RER Q +RER + R +QR + +R+K
Sbjct: 114 RNRKGGRE----RDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKK 169
Query: 519 RELSRAERARHEALLQGRTRQQRQEREG 546
++ R E + + R+ ++ + G
Sbjct: 170 ERKKERKKERKEKKKEEKRREDKKRKWG 197
Score = 70.5 bits (171), Expect = 4e-12
Identities = 53/192 (27%), Positives = 87/192 (45%), Gaps = 6/192 (3%)
Query: 392 QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAER 451
+R+ +RE R E R + ER + RE R R R R+ +R +R + ER
Sbjct: 2 ERQRERKRETDRGKETERE--RDRQRERENQTERENRHRQRDRHRERDRQTDREK---ER 56
Query: 452 QGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR-Q 510
+ R+R + RE +Q + +QRE Q RER + RER + R ++R +
Sbjct: 57 ERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNR 116
Query: 511 EGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRK 570
+G +R+K+ +R R + R RQ+++ER+ +E + RK
Sbjct: 117 KGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERK 176
Query: 571 LERSEQLTRERR 582
ER E+ E+R
Sbjct: 177 KERKEKKKEEKR 188
Score = 59.3 bits (142), Expect = 1e-08
Identities = 51/195 (26%), Positives = 83/195 (42%), Gaps = 9/195 (4%)
Query: 416 VEERRGRRGREEREAARRRQRQYERSEERR--RELAERQGLLRRERAERAAREDRLRKLQ 473
+E +R R+ +R R+R +R E + RE RQ RER + RE + +
Sbjct: 1 MERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQK 60
Query: 474 QEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALL 533
+ +QRE + ER + +R+R ++ ++R + + + KRE +R R
Sbjct: 61 ERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRE---TDRNRERNRK 117
Query: 534 QGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQL---TRERRSALESARS 590
GR R ++ ERE R E R +E R+ +R Q ER+ + R
Sbjct: 118 GGRERDKQTERERDRER-ERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERK 176
Query: 591 TARASFHVREKVREE 605
R EK RE+
Sbjct: 177 KERKEKKKEEKRRED 191
Score = 53.5 bits (127), Expect = 6e-07
Identities = 53/178 (29%), Positives = 75/178 (42%), Gaps = 24/178 (13%)
Query: 434 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
RQR+ +R +R +E ER+ +RER + RE+R R+ + RER
Sbjct: 3 RQRERKRETDRGKE-TERERDRQRERENQTERENRHRQRDRH-------------RERDR 48
Query: 494 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
Q RE+ + + + RQ QRE+ ER R + R RQ +ER+ R
Sbjct: 49 QTDREKERERQKERDRQR---QRERETERETERQRERQRQRERKRQTDRERDKDRDR--- 102
Query: 554 SLGRAQENYEHLAIGRK--LERSEQLTRERRSALESARSTARASFHVREKVREETNTR 609
R +E + RK ER +Q RER E R R RE+ RE R
Sbjct: 103 --ERKRETDRNRERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRER 158
Score = 44.3 bits (103), Expect = 3e-04
Identities = 46/178 (25%), Positives = 75/178 (42%), Gaps = 36/178 (20%)
Query: 330 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 389
Q +H ER RQ E+ ERDR+ R +E E Q E QR
Sbjct: 39 QRDRHRERD-RQTDREKERERQKERDRQ-------RQRER----ETERETERQRERQRQR 86
Query: 390 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE-------------------EREA 430
++R+ ER+K R E+ R + R+G R R+ ER+
Sbjct: 87 ERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTERERDRERERQRQRERERQR 146
Query: 431 ARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG 488
R R+R+ +R +R E ER+ ++ER +++R K ++E+ + ++ EG
Sbjct: 147 QRERKRETDRERQRWAEREERKKERKKER-----KKERKEKKKEEKRREDKKRKWGEG 199
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 80.5 bits (197), Expect = 4e-15
Identities = 57/237 (24%), Positives = 119/237 (50%), Gaps = 24/237 (10%)
Query: 373 LEQRAAAHGQWELQRV------------HAKQRREREEREKQRALEQGRRAWAAQVEERR 420
+ RAA ELQ V +++++ER EREK++ + R +E++
Sbjct: 5 ISSRAAVKLNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKK 64
Query: 421 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 480
R+ RE + R++++ E+ + RRE R+ +++ ER R R RK ++E+ K+
Sbjct: 65 KRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKER--KE 122
Query: 481 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540
RE ++ RER + RR++ +R R ++++ G+ +R++++ + ER + + R R++
Sbjct: 123 RERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKK----RERNRKE 178
Query: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 597
R++ + E R +E +K ER + +R++ + R ++F+
Sbjct: 179 RKKERERKERRERKKERKKER------RKKKERKKDRKTDRQTDSQVFRPLRESAFN 229
Score = 79.3 bits (194), Expect = 1e-14
Identities = 51/198 (25%), Positives = 104/198 (52%), Gaps = 9/198 (4%)
Query: 418 ERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQN 477
+R R +E RE R +R+ ER +ER+RE +++ R++R ER +R RK +++Q
Sbjct: 31 QRESERKKERRE---REKRKREREKERKRERGKKEKKKRKKR-ERGKERERKRKEREKQR 86
Query: 478 LKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRT 537
++RE+ + + + E+ +RER QR R +++++ + +RE+ R ER R + + R
Sbjct: 87 KERREK--ERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRR 144
Query: 538 RQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 597
+++++E+E + + + +E + RK + E+ +ERR + + R
Sbjct: 145 KERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKK-- 202
Query: 598 VREKVREETNTRSFDRMV 615
+E+ ++ R D V
Sbjct: 203 -KERKKDRKTDRQTDSQV 219
Score = 59.3 bits (142), Expect = 1e-08
Identities = 44/193 (22%), Positives = 88/193 (45%), Gaps = 13/193 (6%)
Query: 439 ERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRE 498
+R ER++E RRER +R ++ RK ++ + K++ + + G+ER E+ R+E
Sbjct: 31 QRESERKKE--------RREREKRKREREKERKRERGKKEKKKRKKRERGKER-ERKRKE 81
Query: 499 RAQRAARAKQRQEGQLQREKRELSRAERARHEAL----LQGRTRQQRQEREGLRSSLEAS 554
R ++ ++++ + ++EK++ R +R R E + R R+ +Q RE R
Sbjct: 82 REKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKK 141
Query: 555 LGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRM 614
R + E R+ +R ++ ER E R + +E+ + + R
Sbjct: 142 KRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRK 201
Query: 615 VREAQLHASLDRK 627
+E + DR+
Sbjct: 202 KKERKKDRKTDRQ 214
Score = 51.2 bits (121), Expect = 3e-06
Identities = 42/186 (22%), Positives = 95/186 (51%), Gaps = 17/186 (9%)
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
++ + ERG + +R ++ R ++E +QR + +R K++RER++R
Sbjct: 52 KERKRERGKKEKKKRKKRERGKERERKRKERE--KQRKERREKERRKRKKEKKKRERKQR 109
Query: 400 ----EKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLL 455
K++ + R Q ER+ ++ R+++ R++ + ER+R+
Sbjct: 110 GRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRK-------- 161
Query: 456 RRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQ-EGQL 514
+R++ ER + +R RK ++++ ++R+E + +ER ++ R+++ ++ R RQ + Q+
Sbjct: 162 KRKKEEREKKRERNRKERKKE--RERKERRERKKERKKERRKKKERKKDRKTDRQTDSQV 219
Query: 515 QREKRE 520
R RE
Sbjct: 220 FRPLRE 225
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 80.5 bits (197), Expect = 4e-15
Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)
Query: 155 EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
+AER AK Q R + E + REE KR + L ++ A A A A +
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1442
Query: 207 SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
A R+ + R Q + G L +L R E A + +
Sbjct: 1443 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 267 ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
A + ES R+ + ++R A +A A L L R
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1551
Query: 320 FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
++ + Q +E R AE + + K A L + +E + + + R A
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1610
Query: 380 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
+ + Q+ A++ RE ERE +R + A +++ + + +A +Q++
Sbjct: 1611 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669
Query: 440 RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
E RRR AE Q + +RE AE+ + R ++L EQ L + E+G Q+
Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1729
Query: 489 RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
+ E++ R + + AA ++RQE + + K RA E LL + R + + R E
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1783
Query: 546 GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
+ LEA GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1759
Query: 165 CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
RAE E ++ + R + + + A + A+ + A A R+
Sbjct: 1760 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816
Query: 225 ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
+ A Q A K ++ +R + A E E LR L
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 1872
Query: 285 RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
A R +A + R + L + G + + + + VE + ++A
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1932
Query: 345 --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 1933 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1990
Query: 399 -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2046
Query: 448 LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+
Sbjct: 2047 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2097
Query: 508 QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
+ E + + +R++ AER + A Q + R Q Q E LR E R + E A
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2156
Query: 567 IGRKLERSEQLTRERRSALESARSTAR 593
+ +K ++ + ++ A ++ R A+
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2183
Score = 70.5 bits (171), Expect = 4e-12
Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)
Query: 155 EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
E ER +AK+++ R RER +E R+L A A A A + +L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 214 PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
+ AAR+A+ AR Q +++ R+ + L + E + +
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129
Query: 266 GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
A +++ E RA A + ++ R A +T
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189
Query: 317 GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
L + H ++ +++++AE +R + L R Q EEL L+
Sbjct: 2190 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 376 RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
R A + + R QR +EE EK + QV E R +EAAR R
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2294
Query: 435 QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
Q LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A+
Sbjct: 2295 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2340
Query: 495 IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
E+A+R K++ QL E + R A R RQ E R L A
Sbjct: 2341 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2390
Query: 554 SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
+ RAQ E A IG KL R+E T+E+ + +++ + S H E++RE
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 605 ETN--TRSFDRMVREAQL 620
R +++ +EA+L
Sbjct: 2451 AIAELEREKEKLQQEAKL 2468
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 325 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1337 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1381
Query: 385 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1382 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 443 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496
Query: 479 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556
Query: 533 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1557 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 330 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033
Query: 383 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2088
Query: 434 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2089 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2136
Query: 494 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2189
Query: 554 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2190 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 353 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392
Query: 408 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2393 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452
Query: 446 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2511
Query: 504 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2512 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Query: 564 HLAIGRKLERSEQLTRERRSALE 586
+ RK E +QL ++RR E
Sbjct: 2565 --GVRRKQEELQQLEQQRRQQEE 2585
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 336 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2351 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2409
Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 453 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2470 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2528
Query: 502 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2529 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2587
Query: 557 RAQENYEHLAIGRKLERSEQLTRERRSAL 585
A+EN R E+ + L + R+AL
Sbjct: 2588 -AEENQ------RLREQLQLLEEQHRAAL 2609
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 367 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2561
Query: 427 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621
Query: 474 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2622 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2681
Query: 521 LSRAERARHEALLQGRT 537
L+R E RH LQGR+
Sbjct: 2682 LARREDVRH--YLQGRS 2696
Score = 49.7 bits (117), Expect = 8e-06
Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2152
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2212
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
A+ A RS M + L EAE RA + + + +R ++EE +
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272
Query: 180 LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
+ AA + AA A+ + + A A + A +
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 233 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2388
Query: 285 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
RA AR A G T + + + L Q + H +
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2449 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2504
Query: 394 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2557
Query: 454 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2558 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2597
Query: 514 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2598 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2654
Query: 574 SEQLTRERRSALESARSTARASFHVREKVREE 605
+++L + E + A+ V E R E
Sbjct: 2655 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2686
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 331 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1081 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1130
Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1131 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1180
Query: 451 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240
Query: 488 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1300
Query: 529 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1360
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1361 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1399
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 80.5 bits (197), Expect = 4e-15
Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)
Query: 155 EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
+AER AK Q R + E + REE KR + L ++ A A A A +
Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1446
Query: 207 SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
A R+ + R Q + G L +L R E A + +
Sbjct: 1447 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1495
Query: 267 ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
A + ES R+ + ++R A +A A L L R
Sbjct: 1496 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1555
Query: 320 FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
++ + Q +E R AE + + K A L + +E + + + R A
Sbjct: 1556 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1614
Query: 380 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
+ + Q+ A++ RE ERE +R + A +++ + + +A +Q++
Sbjct: 1615 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1673
Query: 440 RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
E RRR AE Q + +RE AE+ + R ++L EQ L + E+G Q+
Sbjct: 1674 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1733
Query: 489 RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
+ E++ R + + AA ++RQE + + K RA E LL + R + + R E
Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1787
Query: 546 GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
+ LEA GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1843
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1712
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1713 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1763
Query: 165 CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
RAE E ++ + R + + + A + A+ + A A R+
Sbjct: 1764 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1820
Query: 225 ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
+ A Q A K ++ +R + A E E LR L
Sbjct: 1821 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 1876
Query: 285 RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
A R +A + R + L + G + + + + VE + ++A
Sbjct: 1877 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1936
Query: 345 --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 1937 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1994
Query: 399 -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 1995 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2050
Query: 448 LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+
Sbjct: 2051 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2101
Query: 508 QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
+ E + + +R++ AER + A Q + R Q Q E LR E R + E A
Sbjct: 2102 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2160
Query: 567 IGRKLERSEQLTRERRSALESARSTAR 593
+ +K ++ + ++ A ++ R A+
Sbjct: 2161 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2187
Score = 70.5 bits (171), Expect = 4e-12
Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)
Query: 155 EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
E ER +AK+++ R RER +E R+L A A A A + +L
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2073
Query: 214 PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
+ AAR+A+ AR Q +++ R+ + L + E + +
Sbjct: 2074 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2133
Query: 266 GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
A +++ E RA A + ++ R A +T
Sbjct: 2134 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2193
Query: 317 GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
L + H ++ +++++AE +R + L R Q EEL L+
Sbjct: 2194 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2249
Query: 376 RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
R A + + R QR +EE EK + QV E R +EAAR R
Sbjct: 2250 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2298
Query: 435 QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
Q LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A+
Sbjct: 2299 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2344
Query: 495 IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
E+A+R K++ QL E + R A R RQ E R L A
Sbjct: 2345 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2394
Query: 554 SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
+ RAQ E A IG KL R+E T+E+ + +++ + S H E++RE
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454
Query: 605 ETN--TRSFDRMVREAQL 620
R +++ +EA+L
Sbjct: 2455 AIAELEREKEKLQQEAKL 2472
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 325 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1341 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1385
Query: 385 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1386 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1440
Query: 443 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1441 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1500
Query: 479 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1501 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1560
Query: 533 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1561 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1619
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1620 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1671
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 330 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 1978 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2037
Query: 383 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2092
Query: 434 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2093 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2140
Query: 494 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2141 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2193
Query: 554 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2194 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 353 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2396
Query: 408 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2397 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2456
Query: 446 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2457 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2515
Query: 504 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2516 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2568
Query: 564 HLAIGRKLERSEQLTRERRSALE 586
+ RK E +QL ++RR E
Sbjct: 2569 --GVRRKQEELQQLEQQRRQQEE 2589
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 336 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2355 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2413
Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2414 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2473
Query: 453 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2474 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2532
Query: 502 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2533 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2591
Query: 557 RAQENYEHLAIGRKLERSEQLTRERRSAL 585
A+EN R E+ + L + R+AL
Sbjct: 2592 -AEENQ------RLREQLQLLEEQHRAAL 2613
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 367 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2508 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2565
Query: 427 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2566 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2625
Query: 474 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2626 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2685
Query: 521 LSRAERARHEALLQGRT 537
L+R E RH LQGR+
Sbjct: 2686 LARREDVRH--YLQGRS 2700
Score = 49.7 bits (117), Expect = 8e-06
Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2098 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2156
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2157 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2216
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
A+ A RS M + L EAE RA + + + +R ++EE +
Sbjct: 2217 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2276
Query: 180 LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
+ AA + AA A+ + + A A + A +
Sbjct: 2277 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2336
Query: 233 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2392
Query: 285 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
RA AR A G T + + + L Q + H +
Sbjct: 2393 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2452
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2453 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2508
Query: 394 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2509 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2561
Query: 454 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2562 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2601
Query: 514 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2602 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2658
Query: 574 SEQLTRERRSALESARSTARASFHVREKVREE 605
+++L + E + A+ V E R E
Sbjct: 2659 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2690
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 331 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1085 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1134
Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1135 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1184
Query: 451 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1185 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1244
Query: 488 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1245 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1304
Query: 529 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1305 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1364
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1365 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1403
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 80.5 bits (197), Expect = 4e-15
Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)
Query: 155 EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
+AER AK Q R + E + REE KR + L ++ A A A A +
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1442
Query: 207 SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
A R+ + R Q + G L +L R E A + +
Sbjct: 1443 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 267 ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
A + ES R+ + ++R A +A A L L R
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1551
Query: 320 FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
++ + Q +E R AE + + K A L + +E + + + R A
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1610
Query: 380 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
+ + Q+ A++ RE ERE +R + A +++ + + +A +Q++
Sbjct: 1611 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669
Query: 440 RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
E RRR AE Q + +RE AE+ + R ++L EQ L + E+G Q+
Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1729
Query: 489 RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
+ E++ R + + AA ++RQE + + K RA E LL + R + + R E
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1783
Query: 546 GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
+ LEA GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1759
Query: 165 CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
RAE E ++ + R + + + A + A+ + A A R+
Sbjct: 1760 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816
Query: 225 ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
+ A Q A K ++ +R + A E E LR L
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 1872
Query: 285 RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
A R +A + R + L + G + + + + VE + ++A
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1932
Query: 345 --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 1933 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1990
Query: 399 -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2046
Query: 448 LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+
Sbjct: 2047 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2097
Query: 508 QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
+ E + + +R++ AER + A Q + R Q Q E LR E R + E A
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2156
Query: 567 IGRKLERSEQLTRERRSALESARSTAR 593
+ +K ++ + ++ A ++ R A+
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2183
Score = 70.5 bits (171), Expect = 4e-12
Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)
Query: 155 EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
E ER +AK+++ R RER +E R+L A A A A + +L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 214 PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
+ AAR+A+ AR Q +++ R+ + L + E + +
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129
Query: 266 GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
A +++ E RA A + ++ R A +T
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189
Query: 317 GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
L + H ++ +++++AE +R + L R Q EEL L+
Sbjct: 2190 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 376 RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
R A + + R QR +EE EK + QV E R +EAAR R
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2294
Query: 435 QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
Q LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A+
Sbjct: 2295 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2340
Query: 495 IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
E+A+R K++ QL E + R A R RQ E R L A
Sbjct: 2341 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2390
Query: 554 SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
+ RAQ E A IG KL R+E T+E+ + +++ + S H E++RE
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 605 ETN--TRSFDRMVREAQL 620
R +++ +EA+L
Sbjct: 2451 AIAELEREKEKLQQEAKL 2468
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 325 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1337 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1381
Query: 385 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1382 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 443 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496
Query: 479 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556
Query: 533 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1557 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 330 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033
Query: 383 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2088
Query: 434 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2089 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2136
Query: 494 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2189
Query: 554 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2190 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 353 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392
Query: 408 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2393 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452
Query: 446 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2511
Query: 504 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2512 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Query: 564 HLAIGRKLERSEQLTRERRSALE 586
+ RK E +QL ++RR E
Sbjct: 2565 --GVRRKQEELQQLEQQRRQQEE 2585
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 336 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2351 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2409
Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 453 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2470 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2528
Query: 502 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2529 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2587
Query: 557 RAQENYEHLAIGRKLERSEQLTRERRSAL 585
A+EN R E+ + L + R+AL
Sbjct: 2588 -AEENQ------RLREQLQLLEEQHRAAL 2609
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 367 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2561
Query: 427 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621
Query: 474 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2622 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2681
Query: 521 LSRAERARHEALLQGRT 537
L+R E RH LQGR+
Sbjct: 2682 LARREDVRH--YLQGRS 2696
Score = 49.7 bits (117), Expect = 8e-06
Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2152
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2212
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
A+ A RS M + L EAE RA + + + +R ++EE +
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272
Query: 180 LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
+ AA + AA A+ + + A A + A +
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 233 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2388
Query: 285 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
RA AR A G T + + + L Q + H +
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2449 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2504
Query: 394 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2557
Query: 454 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2558 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2597
Query: 514 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2598 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2654
Query: 574 SEQLTRERRSALESARSTARASFHVREKVREE 605
+++L + E + A+ V E R E
Sbjct: 2655 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2686
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 331 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1081 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1130
Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1131 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1180
Query: 451 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240
Query: 488 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1300
Query: 529 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1360
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1361 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1399
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 80.5 bits (197), Expect = 4e-15
Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)
Query: 155 EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
+AER AK Q R + E + REE KR + L ++ A A A A +
Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1410
Query: 207 SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
A R+ + R Q + G L +L R E A + +
Sbjct: 1411 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1459
Query: 267 ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
A + ES R+ + ++R A +A A L L R
Sbjct: 1460 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1519
Query: 320 FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
++ + Q +E R AE + + K A L + +E + + + R A
Sbjct: 1520 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1578
Query: 380 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
+ + Q+ A++ RE ERE +R + A +++ + + +A +Q++
Sbjct: 1579 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1637
Query: 440 RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
E RRR AE Q + +RE AE+ + R ++L EQ L + E+G Q+
Sbjct: 1638 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1697
Query: 489 RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
+ E++ R + + AA ++RQE + + K RA E LL + R + + R E
Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1751
Query: 546 GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
+ LEA GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1807
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1676
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1677 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1727
Query: 165 CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
RAE E ++ + R + + + A + A+ + A A R+
Sbjct: 1728 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1784
Query: 225 ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
+ A Q A K ++ +R + A E E LR L
Sbjct: 1785 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 1840
Query: 285 RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
A R +A + R + L + G + + + + VE + ++A
Sbjct: 1841 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1900
Query: 345 --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 1901 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1958
Query: 399 -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 1959 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2014
Query: 448 LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+
Sbjct: 2015 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2065
Query: 508 QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
+ E + + +R++ AER + A Q + R Q Q E LR E R + E A
Sbjct: 2066 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2124
Query: 567 IGRKLERSEQLTRERRSALESARSTAR 593
+ +K ++ + ++ A ++ R A+
Sbjct: 2125 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2151
Score = 70.5 bits (171), Expect = 4e-12
Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)
Query: 155 EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
E ER +AK+++ R RER +E R+L A A A A + +L
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2037
Query: 214 PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
+ AAR+A+ AR Q +++ R+ + L + E + +
Sbjct: 2038 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2097
Query: 266 GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
A +++ E RA A + ++ R A +T
Sbjct: 2098 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2157
Query: 317 GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
L + H ++ +++++AE +R + L R Q EEL L+
Sbjct: 2158 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2213
Query: 376 RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
R A + + R QR +EE EK + QV E R +EAAR R
Sbjct: 2214 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2262
Query: 435 QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
Q LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A+
Sbjct: 2263 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2308
Query: 495 IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
E+A+R K++ QL E + R A R RQ E R L A
Sbjct: 2309 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2358
Query: 554 SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
+ RAQ E A IG KL R+E T+E+ + +++ + S H E++RE
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418
Query: 605 ETN--TRSFDRMVREAQL 620
R +++ +EA+L
Sbjct: 2419 AIAELEREKEKLQQEAKL 2436
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 325 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1305 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1349
Query: 385 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1350 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1404
Query: 443 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1405 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1464
Query: 479 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1465 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1524
Query: 533 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1525 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1583
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1584 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1635
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 330 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 1942 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2001
Query: 383 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2002 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2056
Query: 434 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2057 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2104
Query: 494 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2105 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2157
Query: 554 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2158 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 353 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2360
Query: 408 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2361 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2420
Query: 446 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2421 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2479
Query: 504 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2480 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2532
Query: 564 HLAIGRKLERSEQLTRERRSALE 586
+ RK E +QL ++RR E
Sbjct: 2533 --GVRRKQEELQQLEQQRRQQEE 2553
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 336 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2319 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2377
Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2378 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2437
Query: 453 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2438 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2496
Query: 502 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2497 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2555
Query: 557 RAQENYEHLAIGRKLERSEQLTRERRSAL 585
A+EN R E+ + L + R+AL
Sbjct: 2556 -AEENQ------RLREQLQLLEEQHRAAL 2577
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 367 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2472 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2529
Query: 427 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2530 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2589
Query: 474 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2590 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2649
Query: 521 LSRAERARHEALLQGRT 537
L+R E RH LQGR+
Sbjct: 2650 LARREDVRH--YLQGRS 2664
Score = 49.7 bits (117), Expect = 8e-06
Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2062 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2120
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2121 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2180
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
A+ A RS M + L EAE RA + + + +R ++EE +
Sbjct: 2181 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2240
Query: 180 LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
+ AA + AA A+ + + A A + A +
Sbjct: 2241 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2300
Query: 233 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2356
Query: 285 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
RA AR A G T + + + L Q + H +
Sbjct: 2357 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2416
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2417 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2472
Query: 394 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2473 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2525
Query: 454 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2526 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2565
Query: 514 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2566 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2622
Query: 574 SEQLTRERRSALESARSTARASFHVREKVREE 605
+++L + E + A+ V E R E
Sbjct: 2623 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2654
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 331 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1049 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1098
Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1099 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1148
Query: 451 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1149 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1208
Query: 488 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1209 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1268
Query: 529 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1269 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1328
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1329 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1367
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 80.5 bits (197), Expect = 4e-15
Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)
Query: 155 EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
+AER AK Q R + E + REE KR + L ++ A A A A +
Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1579
Query: 207 SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
A R+ + R Q + G L +L R E A + +
Sbjct: 1580 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628
Query: 267 ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
A + ES R+ + ++R A +A A L L R
Sbjct: 1629 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1688
Query: 320 FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
++ + Q +E R AE + + K A L + +E + + + R A
Sbjct: 1689 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1747
Query: 380 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
+ + Q+ A++ RE ERE +R + A +++ + + +A +Q++
Sbjct: 1748 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1806
Query: 440 RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
E RRR AE Q + +RE AE+ + R ++L EQ L + E+G Q+
Sbjct: 1807 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1866
Query: 489 RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
+ E++ R + + AA ++RQE + + K RA E LL + R + + R E
Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1920
Query: 546 GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
+ LEA GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1845
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1846 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1896
Query: 165 CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
RAE E ++ + R + + + A + A+ + A A R+
Sbjct: 1897 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1953
Query: 225 ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
+ A Q A K ++ +R + A E E LR L
Sbjct: 1954 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 2009
Query: 285 RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
A R +A + R + L + G + + + + VE + ++A
Sbjct: 2010 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 2069
Query: 345 --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 2070 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 2127
Query: 399 -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 2128 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2183
Query: 448 LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+
Sbjct: 2184 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2234
Query: 508 QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
+ E + + +R++ AER + A Q + R Q Q E LR E R + E A
Sbjct: 2235 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2293
Query: 567 IGRKLERSEQLTRERRSALESARSTAR 593
+ +K ++ + ++ A ++ R A+
Sbjct: 2294 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2320
Score = 70.5 bits (171), Expect = 4e-12
Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)
Query: 155 EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
E ER +AK+++ R RER +E R+L A A A A + +L
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2206
Query: 214 PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
+ AAR+A+ AR Q +++ R+ + L + E + +
Sbjct: 2207 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2266
Query: 266 GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
A +++ E RA A + ++ R A +T
Sbjct: 2267 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2326
Query: 317 GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
L + H ++ +++++AE +R + L R Q EEL L+
Sbjct: 2327 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2382
Query: 376 RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
R A + + R QR +EE EK + QV E R +EAAR R
Sbjct: 2383 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2431
Query: 435 QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
Q LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A+
Sbjct: 2432 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2477
Query: 495 IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
E+A+R K++ QL E + R A R RQ E R L A
Sbjct: 2478 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2527
Query: 554 SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
+ RAQ E A IG KL R+E T+E+ + +++ + S H E++RE
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587
Query: 605 ETN--TRSFDRMVREAQL 620
R +++ +EA+L
Sbjct: 2588 AIAELEREKEKLQQEAKL 2605
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 325 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1474 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1518
Query: 385 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1519 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1573
Query: 443 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1574 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1633
Query: 479 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1634 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1693
Query: 533 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1694 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1752
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1753 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1804
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 330 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 2111 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2170
Query: 383 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2225
Query: 434 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2226 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2273
Query: 494 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2274 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2326
Query: 554 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2327 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 353 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2529
Query: 408 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2530 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2589
Query: 446 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2590 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2648
Query: 504 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2649 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2701
Query: 564 HLAIGRKLERSEQLTRERRSALE 586
+ RK E +QL ++RR E
Sbjct: 2702 --GVRRKQEELQQLEQQRRQQEE 2722
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 336 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2488 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2546
Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2547 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606
Query: 453 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2607 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2665
Query: 502 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2666 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2724
Query: 557 RAQENYEHLAIGRKLERSEQLTRERRSAL 585
A+EN R E+ + L + R+AL
Sbjct: 2725 -AEENQ------RLREQLQLLEEQHRAAL 2746
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 367 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2641 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2698
Query: 427 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2699 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2758
Query: 474 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2759 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2818
Query: 521 LSRAERARHEALLQGRT 537
L+R E RH LQGR+
Sbjct: 2819 LARREDVRH--YLQGRS 2833
Score = 49.7 bits (117), Expect = 8e-06
Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2231 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2289
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2290 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2349
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
A+ A RS M + L EAE RA + + + +R ++EE +
Sbjct: 2350 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2409
Query: 180 LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
+ AA + AA A+ + + A A + A +
Sbjct: 2410 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2469
Query: 233 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2525
Query: 285 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
RA AR A G T + + + L Q + H +
Sbjct: 2526 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2585
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2586 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2641
Query: 394 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2642 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2694
Query: 454 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2695 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2734
Query: 514 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2735 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2791
Query: 574 SEQLTRERRSALESARSTARASFHVREKVREE 605
+++L + E + A+ V E R E
Sbjct: 2792 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2823
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 331 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1218 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1267
Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1268 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1317
Query: 451 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1318 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1377
Query: 488 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1378 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1437
Query: 529 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1438 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1497
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1498 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1536
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 80.5 bits (197), Expect = 4e-15
Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)
Query: 155 EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
+AER AK Q R + E + REE KR + L ++ A A A A +
Sbjct: 1363 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1420
Query: 207 SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
A R+ + R Q + G L +L R E A + +
Sbjct: 1421 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469
Query: 267 ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
A + ES R+ + ++R A +A A L L R
Sbjct: 1470 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1529
Query: 320 FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
++ + Q +E R AE + + K A L + +E + + + R A
Sbjct: 1530 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1588
Query: 380 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
+ + Q+ A++ RE ERE +R + A +++ + + +A +Q++
Sbjct: 1589 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1647
Query: 440 RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
E RRR AE Q + +RE AE+ + R ++L EQ L + E+G Q+
Sbjct: 1648 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1707
Query: 489 RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
+ E++ R + + AA ++RQE + + K RA E LL + R + + R E
Sbjct: 1708 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1761
Query: 546 GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
+ LEA GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1817
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1686
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1687 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1737
Query: 165 CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
RAE E ++ + R + + + A + A+ + A A R+
Sbjct: 1738 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1794
Query: 225 ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
+ A Q A K ++ +R + A E E LR L
Sbjct: 1795 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 1850
Query: 285 RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
A R +A + R + L + G + + + + VE + ++A
Sbjct: 1851 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1910
Query: 345 --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 1911 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1968
Query: 399 -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 1969 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2024
Query: 448 LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+
Sbjct: 2025 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2075
Query: 508 QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
+ E + + +R++ AER + A Q + R Q Q E LR E R + E A
Sbjct: 2076 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2134
Query: 567 IGRKLERSEQLTRERRSALESARSTAR 593
+ +K ++ + ++ A ++ R A+
Sbjct: 2135 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2161
Score = 70.5 bits (171), Expect = 4e-12
Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)
Query: 155 EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
E ER +AK+++ R RER +E R+L A A A A + +L
Sbjct: 1988 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2047
Query: 214 PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
+ AAR+A+ AR Q +++ R+ + L + E + +
Sbjct: 2048 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2107
Query: 266 GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
A +++ E RA A + ++ R A +T
Sbjct: 2108 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2167
Query: 317 GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
L + H ++ +++++AE +R + L R Q EEL L+
Sbjct: 2168 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2223
Query: 376 RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
R A + + R QR +EE EK + QV E R +EAAR R
Sbjct: 2224 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2272
Query: 435 QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
Q LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A+
Sbjct: 2273 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2318
Query: 495 IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
E+A+R K++ QL E + R A R RQ E R L A
Sbjct: 2319 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2368
Query: 554 SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
+ RAQ E A IG KL R+E T+E+ + +++ + S H E++RE
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428
Query: 605 ETN--TRSFDRMVREAQL 620
R +++ +EA+L
Sbjct: 2429 AIAELEREKEKLQQEAKL 2446
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 325 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1315 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1359
Query: 385 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1360 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1414
Query: 443 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1415 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1474
Query: 479 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1475 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1534
Query: 533 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1535 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1593
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1594 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1645
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 330 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 1952 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2011
Query: 383 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2066
Query: 434 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2067 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2114
Query: 494 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2115 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2167
Query: 554 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2168 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 353 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2311 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2370
Query: 408 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2371 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2430
Query: 446 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2431 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2489
Query: 504 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2490 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2542
Query: 564 HLAIGRKLERSEQLTRERRSALE 586
+ RK E +QL ++RR E
Sbjct: 2543 --GVRRKQEELQQLEQQRRQQEE 2563
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 336 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2329 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2387
Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2388 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447
Query: 453 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2448 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2506
Query: 502 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2507 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2565
Query: 557 RAQENYEHLAIGRKLERSEQLTRERRSAL 585
A+EN R E+ + L + R+AL
Sbjct: 2566 -AEENQ------RLREQLQLLEEQHRAAL 2587
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 367 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2482 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2539
Query: 427 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2540 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2599
Query: 474 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2600 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2659
Query: 521 LSRAERARHEALLQGRT 537
L+R E RH LQGR+
Sbjct: 2660 LARREDVRH--YLQGRS 2674
Score = 49.7 bits (117), Expect = 8e-06
Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2072 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2130
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2131 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2190
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
A+ A RS M + L EAE RA + + + +R ++EE +
Sbjct: 2191 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2250
Query: 180 LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
+ AA + AA A+ + + A A + A +
Sbjct: 2251 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2310
Query: 233 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2311 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2366
Query: 285 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
RA AR A G T + + + L Q + H +
Sbjct: 2367 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2426
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2427 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2482
Query: 394 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2483 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2535
Query: 454 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2536 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2575
Query: 514 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2576 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2632
Query: 574 SEQLTRERRSALESARSTARASFHVREKVREE 605
+++L + E + A+ V E R E
Sbjct: 2633 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2664
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 331 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1059 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1108
Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1109 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1158
Query: 451 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1159 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1218
Query: 488 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1219 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1278
Query: 529 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1279 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1338
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1339 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1377
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 80.5 bits (197), Expect = 4e-15
Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)
Query: 155 EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
+AER AK Q R + E + REE KR + L ++ A A A A +
Sbjct: 1371 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1428
Query: 207 SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
A R+ + R Q + G L +L R E A + +
Sbjct: 1429 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1477
Query: 267 ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
A + ES R+ + ++R A +A A L L R
Sbjct: 1478 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1537
Query: 320 FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
++ + Q +E R AE + + K A L + +E + + + R A
Sbjct: 1538 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1596
Query: 380 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
+ + Q+ A++ RE ERE +R + A +++ + + +A +Q++
Sbjct: 1597 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1655
Query: 440 RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
E RRR AE Q + +RE AE+ + R ++L EQ L + E+G Q+
Sbjct: 1656 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1715
Query: 489 RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
+ E++ R + + AA ++RQE + + K RA E LL + R + + R E
Sbjct: 1716 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1769
Query: 546 GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
+ LEA GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1825
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1694
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1695 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1745
Query: 165 CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
RAE E ++ + R + + + A + A+ + A A R+
Sbjct: 1746 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1802
Query: 225 ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
+ A Q A K ++ +R + A E E LR L
Sbjct: 1803 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 1858
Query: 285 RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
A R +A + R + L + G + + + + VE + ++A
Sbjct: 1859 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1918
Query: 345 --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 1919 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1976
Query: 399 -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 1977 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2032
Query: 448 LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+
Sbjct: 2033 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2083
Query: 508 QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
+ E + + +R++ AER + A Q + R Q Q E LR E R + E A
Sbjct: 2084 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2142
Query: 567 IGRKLERSEQLTRERRSALESARSTAR 593
+ +K ++ + ++ A ++ R A+
Sbjct: 2143 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2169
Score = 70.5 bits (171), Expect = 4e-12
Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)
Query: 155 EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
E ER +AK+++ R RER +E R+L A A A A + +L
Sbjct: 1996 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2055
Query: 214 PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
+ AAR+A+ AR Q +++ R+ + L + E + +
Sbjct: 2056 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2115
Query: 266 GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
A +++ E RA A + ++ R A +T
Sbjct: 2116 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2175
Query: 317 GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
L + H ++ +++++AE +R + L R Q EEL L+
Sbjct: 2176 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2231
Query: 376 RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
R A + + R QR +EE EK + QV E R +EAAR R
Sbjct: 2232 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2280
Query: 435 QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
Q LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A+
Sbjct: 2281 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2326
Query: 495 IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
E+A+R K++ QL E + R A R RQ E R L A
Sbjct: 2327 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2376
Query: 554 SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
+ RAQ E A IG KL R+E T+E+ + +++ + S H E++RE
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436
Query: 605 ETN--TRSFDRMVREAQL 620
R +++ +EA+L
Sbjct: 2437 AIAELEREKEKLQQEAKL 2454
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 325 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1323 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1367
Query: 385 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1368 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1422
Query: 443 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1423 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1482
Query: 479 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1483 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1542
Query: 533 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1543 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1601
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1602 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1653
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 330 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 1960 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2019
Query: 383 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2020 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2074
Query: 434 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2075 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2122
Query: 494 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2123 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2175
Query: 554 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2176 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2225
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 353 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2319 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2378
Query: 408 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2379 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2438
Query: 446 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2439 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2497
Query: 504 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2498 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2550
Query: 564 HLAIGRKLERSEQLTRERRSALE 586
+ RK E +QL ++RR E
Sbjct: 2551 --GVRRKQEELQQLEQQRRQQEE 2571
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 336 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2337 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2395
Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2396 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2455
Query: 453 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2456 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2514
Query: 502 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2515 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2573
Query: 557 RAQENYEHLAIGRKLERSEQLTRERRSAL 585
A+EN R E+ + L + R+AL
Sbjct: 2574 -AEENQ------RLREQLQLLEEQHRAAL 2595
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 367 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2490 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2547
Query: 427 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2548 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2607
Query: 474 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2608 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2667
Query: 521 LSRAERARHEALLQGRT 537
L+R E RH LQGR+
Sbjct: 2668 LARREDVRH--YLQGRS 2682
Score = 49.7 bits (117), Expect = 8e-06
Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2080 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2138
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2139 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2198
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
A+ A RS M + L EAE RA + + + +R ++EE +
Sbjct: 2199 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2258
Query: 180 LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
+ AA + AA A+ + + A A + A +
Sbjct: 2259 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2318
Query: 233 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2319 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2374
Query: 285 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
RA AR A G T + + + L Q + H +
Sbjct: 2375 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2434
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2435 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2490
Query: 394 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2491 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2543
Query: 454 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2544 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2583
Query: 514 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2584 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2640
Query: 574 SEQLTRERRSALESARSTARASFHVREKVREE 605
+++L + E + A+ V E R E
Sbjct: 2641 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2672
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 331 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1067 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1116
Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1117 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1166
Query: 451 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1167 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1226
Query: 488 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1227 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1286
Query: 529 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1287 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1346
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1347 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1385
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 80.5 bits (197), Expect = 4e-15
Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)
Query: 155 EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
+AER AK Q R + E + REE KR + L ++ A A A A +
Sbjct: 1412 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1469
Query: 207 SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
A R+ + R Q + G L +L R E A + +
Sbjct: 1470 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1518
Query: 267 ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
A + ES R+ + ++R A +A A L L R
Sbjct: 1519 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1578
Query: 320 FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
++ + Q +E R AE + + K A L + +E + + + R A
Sbjct: 1579 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1637
Query: 380 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
+ + Q+ A++ RE ERE +R + A +++ + + +A +Q++
Sbjct: 1638 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1696
Query: 440 RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
E RRR AE Q + +RE AE+ + R ++L EQ L + E+G Q+
Sbjct: 1697 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1756
Query: 489 RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
+ E++ R + + AA ++RQE + + K RA E LL + R + + R E
Sbjct: 1757 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1810
Query: 546 GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
+ LEA GR +E E A R L +E+ R+R+ A E +AR A A + EK+
Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1866
Score = 75.1 bits (183), Expect = 2e-13
Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)
Query: 53 EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
E A S + + A +K E A G+ E+ + +L + + AEG+
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1735
Query: 109 TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
+ L A + +LL LA L REA + + E A+L +
Sbjct: 1736 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1786
Query: 165 CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
RAE E ++ + R + + + A + A+ + A A R+
Sbjct: 1787 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1843
Query: 225 ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
+ A Q A K ++ +R + A E E LR L
Sbjct: 1844 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 1899
Query: 285 RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
A R +A + R + L + G + + + + VE + ++A
Sbjct: 1900 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1959
Query: 345 --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
E+ G E + ++ + + E+ L +++A A Q +L ++RRE EE
Sbjct: 1960 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 2017
Query: 399 -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
R+++ ALE+ R A+VEE R R R E+E+AR+ Q E +++R
Sbjct: 2018 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2073
Query: 448 LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
L E+A A + + ++LQ Q L+Q + L + R AE RR A+ A A+
Sbjct: 2074 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2124
Query: 508 QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
+ E + + +R++ AER + A Q + R Q Q E LR E R + E A
Sbjct: 2125 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2183
Query: 567 IGRKLERSEQLTRERRSALESARSTAR 593
+ +K ++ + ++ A ++ R A+
Sbjct: 2184 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2210
Score = 70.5 bits (171), Expect = 4e-12
Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)
Query: 155 EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
E ER +AK+++ R RER +E R+L A A A A + +L
Sbjct: 2037 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2096
Query: 214 PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
+ AAR+A+ AR Q +++ R+ + L + E + +
Sbjct: 2097 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2156
Query: 266 GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
A +++ E RA A + ++ R A +T
Sbjct: 2157 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2216
Query: 317 GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
L + H ++ +++++AE +R + L R Q EEL L+
Sbjct: 2217 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2272
Query: 376 RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
R A + + R QR +EE EK + QV E R +EAAR R
Sbjct: 2273 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2321
Query: 435 QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
Q LAE +R AE+ +E +++ +Q+ LK E LQ+ +E A+
Sbjct: 2322 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2367
Query: 495 IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
E+A+R K++ QL E + R A R RQ E R L A
Sbjct: 2368 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2417
Query: 554 SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
+ RAQ E A IG KL R+E T+E+ + +++ + S H E++RE
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477
Query: 605 ETN--TRSFDRMVREAQL 620
R +++ +EA+L
Sbjct: 2478 AIAELEREKEKLQQEAKL 2495
Score = 63.5 bits (153), Expect = 5e-10
Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)
Query: 325 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
+S + + + ER+ Q RAE ER+R LA + L Q A AH Q
Sbjct: 1364 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1408
Query: 385 LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
AK + ERE +E Q+ +++ RR AA +++ R +EE + R+ +++
Sbjct: 1409 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1463
Query: 443 ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
R+ E AER L L+ E ER A E +K Q ++
Sbjct: 1464 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1523
Query: 479 KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
++ +Q+ +R Q E A R AAR KQR L+ + + AER +A
Sbjct: 1524 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1583
Query: 533 LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
++ R RQ + E + S EA L + ++ EH+A+ + E R++
Sbjct: 1584 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1642
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
Q R+ E+ R R E +R + AQ A ++
Sbjct: 1643 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1694
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)
Query: 330 QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
Q A ER R+ R ++ L E R RK A + R + EE L +RA
Sbjct: 2001 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2060
Query: 383 WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
+LQ A++R + EE+ +K++ L+Q + + +++ RG E EAARR
Sbjct: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2115
Query: 434 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
E +EE R + AER+ R + E A R +Q+ +++ + + + AE
Sbjct: 2116 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2163
Query: 494 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
++R+E Q AAR Q ++ L+ +++ + AE +H+ + RQ+ Q + L
Sbjct: 2164 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2216
Query: 554 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
+L E +H +K E+L R + A E+AR ++ F VR ++ E
Sbjct: 2217 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2266
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)
Query: 353 ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
++ +++A R QE+ + Q+ A Q + + A+++R+ E ER K R E
Sbjct: 2360 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2419
Query: 408 GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
R A+ + +R R+ EE R QRQ ER E
Sbjct: 2420 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2479
Query: 446 RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
EL + L++E + + ++ +QQEQ L Q + LQ+ E+ ++RER
Sbjct: 2480 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2538
Query: 504 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
+AK Q Q E+++A++ R E Q + +Q QER+ L +S+E + R E E
Sbjct: 2539 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2591
Query: 564 HLAIGRKLERSEQLTRERRSALE 586
+ RK E +QL ++RR E
Sbjct: 2592 --GVRRKQEELQQLEQQRRQQEE 2612
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)
Query: 336 ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
E++ +Q+ E +G + E +R+ M A + L + + RA A + + QR KQ
Sbjct: 2378 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2436
Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
E E+ + L + Q E + ++ + E R + ER +E+ ++ A+
Sbjct: 2437 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496
Query: 453 GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
L + E + +E L++ Q ++ +L QRE +++ + + EQ+ ++ +AQ
Sbjct: 2497 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2555
Query: 502 RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
+ +QRQ+ Q+++E++ L A R +HEA R +Q+ Q+ E R E L
Sbjct: 2556 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2614
Query: 557 RAQENYEHLAIGRKLERSEQLTRERRSAL 585
A+EN R E+ + L + R+AL
Sbjct: 2615 -AEENQ------RLREQLQLLEEQHRAAL 2636
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)
Query: 367 QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
Q E + +++A ++ + A+Q RE ++R+ Q+ +EQ R+ A +EE R RR E
Sbjct: 2531 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2588
Query: 427 EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
E RR+Q + ++ E++RR+ LAE LR E RAA E ++
Sbjct: 2589 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2648
Query: 474 QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
+ L + L AE R+ AQR A +LQR + E
Sbjct: 2649 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2708
Query: 521 LSRAERARHEALLQGRT 537
L+R E RH LQGR+
Sbjct: 2709 LARREDVRH--YLQGRS 2723
Score = 49.7 bits (117), Expect = 8e-06
Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)
Query: 24 EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
EE + AE + V Q A+E A + A A A+A RK E AA +
Sbjct: 2121 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2179
Query: 84 EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
EQ+ L + + + A+ + + T LE E L R
Sbjct: 2180 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2239
Query: 132 LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
A+ A RS M + L EAE RA + + + +R ++EE +
Sbjct: 2240 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2299
Query: 180 LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
+ AA + AA A+ + + A A + A +
Sbjct: 2300 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2359
Query: 233 RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
+ Q A + R + ++++ L+ E+ + E R+L
Sbjct: 2360 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2415
Query: 285 -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
RA AR A G T + + + L Q + H +
Sbjct: 2416 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2475
Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
R+ AE L E+ ++ A L+ + +E E LL E +A Q L + +
Sbjct: 2476 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2531
Query: 394 REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
RER +++ LEQ + A+ ++ R + R++++ + RQR EE RR
Sbjct: 2532 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2584
Query: 454 LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
R+ + E+ +++++E LQ+ EQ RR++ + A QR Q
Sbjct: 2585 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2624
Query: 514 LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
LQ E RA A E + + + G R +L+ A+ + + RK+
Sbjct: 2625 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2681
Query: 574 SEQLTRERRSALESARSTARASFHVREKVREE 605
+++L + E + A+ V E R E
Sbjct: 2682 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2713
Score = 38.5 bits (88), Expect = 0.019
Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)
Query: 331 TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
+A ++E++ RG +G E +L H+E+L E +A EL+ A
Sbjct: 1108 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1157
Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
++ R + E Q+ R +E RG + ER +QR ER E R
Sbjct: 1158 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1207
Query: 451 RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
LL R +A A + R R+L+Q Q+ ++R+E +Q +
Sbjct: 1208 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1267
Query: 488 GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
+ EQ+R+E+A QR A+ A + E QL K +L
Sbjct: 1268 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1327
Query: 529 HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
+ +Q + QE LR+ + R E E LA ++ E E
Sbjct: 1328 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1387
Query: 576 QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
+L E +ALE R A A H + K + E + + ++E
Sbjct: 1388 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1426
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 78.2 bits (191), Expect = 2e-14
Identities = 94/349 (26%), Positives = 135/349 (38%), Gaps = 39/349 (11%)
Query: 220 RAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRE 279
R +R+ + P SR+ R +H R S SY LRE
Sbjct: 477 RDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLRE 536
Query: 280 LRWPPRASARNSCPAGSASSTTN-----APGRPSALTLVPITGRSFSLGDL--SHSPQTA 332
R RN S S N + GR L P G S G SHS +
Sbjct: 537 ES--SRTEIRNESRNESRSEIRNDRMGRSRGRVPEL---PEKGSRGSRGSQIDSHSSNSN 591
Query: 333 QHVERIVRQVRAERGLRGVPERDRKIAALMLA---RHQEELLLLEQRAAAHGQWELQRVH 389
H R ER PERD + A + RH E + ++
Sbjct: 592 YHDSWETRSSYPERDR--YPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQG 649
Query: 390 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRREL 448
ER+ER ++R +++ V++RR R RE +RE R R+R+ ER ER RE
Sbjct: 650 RNDELERDERREERRVDR--------VDDRRDERARERDRERERDRERERERERERDRE- 700
Query: 449 AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQ 508
E++ L RERA RE +++E + R+R RER + R K+
Sbjct: 701 REKERELERERARERERE------------REKERDRERDRDRDHDRERERERERDREKE 748
Query: 509 RQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGR 557
R+ + +RE+ ER R + R R++ +ERE R + GR
Sbjct: 749 REREREERERERERERERERERERERERARERDKERERQRDWEDKDKGR 797
Score = 73.2 bits (178), Expect = 7e-13
Identities = 71/276 (25%), Positives = 126/276 (45%), Gaps = 42/276 (15%)
Query: 386 QRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE-----EREAARRRQRQYER 440
+R ++R EREK+R LE+ R + E+ R R+ +RE R R+R E+
Sbjct: 688 ERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREK 747
Query: 441 SEERRRELAERQGLLRRERAERAARE-----DRLRKLQQEQNLKQREEGLQEGRERAEQI 495
ER RE ER+ RER RE +R ++ +++++ + +++G + RE+ E+I
Sbjct: 748 EREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEI 807
Query: 496 RRER------AQRAARAKQRQEG-----QLQREKRELSRAERA---------RHEALLQ- 534
R +R +R ++ + R EG Q + +RE S A +H L Q
Sbjct: 808 REDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQV 867
Query: 535 GRTRQQR--------QEREGLRSSLEASLGRAQEN--YEHLAIGRKLERSEQLTRERRSA 584
R ++ R ++R+G + R + + YE + K+ S RE+
Sbjct: 868 VRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVS-SVDKQREQTEI 926
Query: 585 LESARSTARASFHVREKVREETNTRSFDRMVREAQL 620
LES+R A+ + ET+ R+ D ++A++
Sbjct: 927 LESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKI 962
Score = 68.6 bits (166), Expect = 2e-11
Identities = 59/206 (28%), Positives = 95/206 (46%), Gaps = 21/206 (10%)
Query: 345 ERGLRGVPERDRKIAALMLARHQ---EELLLLEQRAAAHGQWELQRV-HAKQRREREERE 400
ER R ERD++ ++ + RHQ +EL E+R E +RV RR+ RE
Sbjct: 628 ERDRRDNRERDQRPSSPI--RHQGRNDELERDERR-------EERRVDRVDDRRDERARE 678
Query: 401 KQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERA 460
+ R E+ R + E R R +ERE R R R+ ER E+ R+ +
Sbjct: 679 RDRERERDRER-ERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRER 737
Query: 461 ERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRE 520
ER DR ++ ++E+ ++RE + RER + RERA+ + ++RQ ++K
Sbjct: 738 ERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGR 797
Query: 521 LSRAERARHEALLQGRTRQQRQEREG 546
R E+ + R+ R R+G
Sbjct: 798 DDRREK-------REEIREDRNPRDG 816
Score = 63.9 bits (154), Expect = 4e-10
Identities = 115/492 (23%), Positives = 175/492 (35%), Gaps = 53/492 (10%)
Query: 168 ERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASP 227
+R R ++ + P S + A + +S + SS S SS SP+PR RK +P
Sbjct: 299 DRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRH-SPSPR--RKRTP 355
Query: 228 SPSSARTQPPPAG-SRTGRKSHSLDSLSRR----REGALSSESGASSSSYSGESLRELRW 282
SPS RT PP S + SHSL S R+ R + E G + +S + R
Sbjct: 356 SPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQS-HDRRH 414
Query: 283 PPRASARNSCPAGSAS------STTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVE 336
R R S + R P GR D + T E
Sbjct: 415 ERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGR-----DRRDARDTRDRRE 469
Query: 337 -RIVRQVRAERGLRGVPE-----RDRKIAALMLARH------------QEELLLLEQRAA 378
R R +R R +R RD + + H +E+ E R+
Sbjct: 470 LRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSY 529
Query: 379 A--HGQWELQRVHAKQRREREEREKQRALEQGR-RAWAAQVEERRGRRGREEREAARRRQ 435
H + E R + E R + R GR R ++ E+ R R + +
Sbjct: 530 GRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSN 589
Query: 436 RQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQI 495
Y S E R ER R+ ++A R+ + RE + Q
Sbjct: 590 SNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQG 649
Query: 496 RRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASL 555
R + +R R ++R+ ++ R ERAR + R R++ +ERE R
Sbjct: 650 RNDELERDERREERRVDRVDDR-----RDERARERDRERERDRERERERERERD------ 698
Query: 556 GRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMV 615
R +E L R ER + +ER + R R RE+ RE+ R +
Sbjct: 699 -REREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERE 757
Query: 616 REAQLHASLDRK 627
RE + +R+
Sbjct: 758 RERERERERERE 769
Score = 62.0 bits (149), Expect = 2e-09
Identities = 62/240 (25%), Positives = 103/240 (42%), Gaps = 28/240 (11%)
Query: 380 HGQWELQRVHAKQRR--EREEREKQRALEQGRRAWAAQVEERRGRRGREEREAA--RRRQ 435
H WE + + ++ R ER+ R++ R RR +RR R R++R ++ R +
Sbjct: 593 HDSWETRSSYPERDRYPERDNRDQARDSSFERRHGE---RDRRDNRERDQRPSSPIRHQG 649
Query: 436 RQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQI 495
R E + RRE R + R ERA DR R+ +E+ ++RE RE+ ++
Sbjct: 650 RNDELERDERRE-ERRVDRVDDRRDERARERDRERERDRERE-RERERERDREREKEREL 707
Query: 496 RRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASL 555
RERA+ R ++++ R+ R H+ R R++ +ER+ +
Sbjct: 708 ERERAREREREREKE--------RDRERDRDRDHD-----RERERERERDREKERERERE 754
Query: 556 GRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS------FHVREKVREETNTR 609
R +E R+ ER + RER E R RE++RE+ N R
Sbjct: 755 ERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPR 814
Score = 49.7 bits (117), Expect = 8e-06
Identities = 90/419 (21%), Positives = 159/419 (37%), Gaps = 50/419 (11%)
Query: 184 LSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRT 243
L P A A A + P+ ++++ ++A+ ++ A + A+P+ ++ T A +
Sbjct: 1100 LLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTF---ANEDS 1156
Query: 244 GRKSHSL-------------DSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARN 290
RK H D+ R+ S S S+ S + LR P SA
Sbjct: 1157 HRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHR 1216
Query: 291 SCPAGSASSTTNAPG---RPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERG 347
S S G R +L ITG S D + ++ + R+
Sbjct: 1217 SGDDQSGRKRVLHSGSRDREKTKSL-EITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSS 1275
Query: 348 LRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQ 407
R PE DR++ + + + L R +E R ++RR+ +RE R ++
Sbjct: 1276 RRSSPESDRQVHSRSGSFDSRDRLQERDR------YEHDRERERERRDTRQREWDRDADK 1329
Query: 408 GRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAARED 467
W R+ R R+R+ ER ++RR+L + L + ER D
Sbjct: 1330 D---WP------------RNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRD 1374
Query: 468 RLRKLQQEQ--NLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREK--RELSR 523
R R + Q ++K+ E L+ ER + A K+R + L + E ++
Sbjct: 1375 RDRTFESSQIESVKRCEAKLEGEHER--DLESTSRDSLALDKERMDKDLGSVQGFEETNK 1432
Query: 524 AERARHEALLQGRTRQQRQEREGLRSSL-EASLGRAQENYEHLAIGRKLERSEQLTRER 581
+ER E+L G + + L S E + + + + G +R +Q E+
Sbjct: 1433 SERT--ESLEAGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEK 1489
>gi|224593756 hypothetical protein LOC164127 [Homo sapiens]
Length = 623
Score = 77.4 bits (189), Expect = 4e-14
Identities = 72/272 (26%), Positives = 130/272 (47%), Gaps = 4/272 (1%)
Query: 351 VPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRR 410
V +D++I AL+L R ++ + E + A WE + ++ + ERE++ L Q +
Sbjct: 252 VSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQE 311
Query: 411 AWAAQVEERRGRRGREEREAARRRQRQ-YERSEERRRELAERQGLLRRERAERAAREDRL 469
W + E+R+ + E+R R QR+ E R +E E Q R+E+ E+A +
Sbjct: 312 QW-QEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEH 370
Query: 470 RKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARH 529
RK Q + L+++E+ L+ RE+ + R A R + + Q++ ++ + + +
Sbjct: 371 RKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINY 430
Query: 530 EALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESAR 589
+A Q + E + SLE S R+QE ++ L R+ E E+ +E L+ AR
Sbjct: 431 QARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQ-LQQAR 489
Query: 590 STARASFHVREKVREETNTRSFDRMVREAQLH 621
A S R K+R+ D +R+A+ H
Sbjct: 490 WRAGESEEQR-KMRKRILVELADEKIRQARSH 520
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 77.0 bits (188), Expect = 5e-14
Identities = 68/255 (26%), Positives = 110/255 (43%), Gaps = 20/255 (7%)
Query: 358 IAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVE 417
I A+ + + +L+ E +L+ K+ +ER+E EK+R + R E
Sbjct: 264 INAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERER------E 317
Query: 418 ERRGRRGRE-EREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQ 476
R RR RE ERE R R+++ ER ER R+ + R +R DR R+ ++
Sbjct: 318 RERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDR 377
Query: 477 NLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGR 536
N K R ++ R+R + RER + R ++R +RE+ ER R + R
Sbjct: 378 N-KDRSRSREKSRDRERERERERERERERERER-----EREREREREREREREREKDKKR 431
Query: 537 TRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASF 596
R++ +E R LE L + Y+ +L+ E RER+ E + R
Sbjct: 432 DREEDEEDAYERRKLERKLREKEAAYQ-----ERLKNWE--IRERKKTREYEKEAEREEE 484
Query: 597 HVREKVREETNTRSF 611
RE +E + F
Sbjct: 485 RRREMAKEAKRLKEF 499
Score = 62.8 bits (151), Expect = 9e-10
Identities = 50/213 (23%), Positives = 97/213 (45%), Gaps = 15/213 (7%)
Query: 349 RGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQG 408
+G E++R+ + R + E +R + E +R +++ + ERE++R ++
Sbjct: 295 KGKKEKERQ--EIEKERRERERERERERERREREREREREREREKEKERERERERDRDRD 352
Query: 409 RRAWAAQVEERRGRRGRE---------EREAARRRQRQYERSEERRRELAERQGLLRRER 459
R + +R R R+ +R +R + R ER ER RE ER+ RER
Sbjct: 353 RTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERE-RERERERERER 411
Query: 460 AERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKR 519
RE + +++ + REE ++ ER + R+ R + AA ++ + +++ K+
Sbjct: 412 EREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKK 471
Query: 520 ELSRAERARHEALLQGRTRQQRQEREGLRSSLE 552
+ A E + R R+ +E + L+ LE
Sbjct: 472 TREYEKEAERE---EERRREMAKEAKRLKEFLE 501
Score = 60.8 bits (146), Expect = 4e-09
Identities = 74/302 (24%), Positives = 116/302 (38%), Gaps = 38/302 (12%)
Query: 339 VRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREE 398
+ + R ER ER+R+ R +E E+ + R + R E
Sbjct: 305 IEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRE 364
Query: 399 REKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRRE---------- 447
R++ R E+ + R R RE ERE R R+R+ ER ER RE
Sbjct: 365 RDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERERERE 424
Query: 448 ---------------LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERA 492
ER+ L R+ R + AA ++RL+ + + K RE ++ ER
Sbjct: 425 REKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTRE--YEKEAERE 482
Query: 493 EQIRRERAQRAARAKQ--------RQEGQLQREKRELSRAERARHEALLQGRTR-QQRQE 543
E+ RRE A+ A R K+ R + + R R E R R ++++E
Sbjct: 483 EERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEE 542
Query: 544 REGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVR 603
E +R L A G + E + ++ ER Q ++ E + RE+
Sbjct: 543 LEEIRQRLLAE-GHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPM 601
Query: 604 EE 605
EE
Sbjct: 602 EE 603
Score = 59.7 bits (143), Expect = 8e-09
Identities = 51/189 (26%), Positives = 84/189 (44%), Gaps = 12/189 (6%)
Query: 442 EERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE--EGLQEGRERAEQIRRER 499
EE +R+L R E + D +KL++E+ K++E E +E RER + RER
Sbjct: 270 EEDKRDLISR---------EISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERER 320
Query: 500 AQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEAS-LGRA 558
+R ++ +E + ++EK ER R + R R + +ER+ R +S +
Sbjct: 321 ERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKD 380
Query: 559 QENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREA 618
+ + R+ ER + RER E R R RE+ RE+ R + +A
Sbjct: 381 RSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDA 440
Query: 619 QLHASLDRK 627
L+RK
Sbjct: 441 YERRKLERK 449
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/206 (24%), Positives = 89/206 (43%), Gaps = 45/206 (21%)
Query: 415 QVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQ 474
++EE +G++ +E +E + R+ ER ER RE RER ER +R R+ ++
Sbjct: 290 KLEEEKGKKEKERQEIEKERR---ERERERERE---------RERREREREREREREREK 337
Query: 475 EQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQ 534
E+ ++RE R+R ++ R+R + R + R+ + + R SR +
Sbjct: 338 EKE-RERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREK--------- 387
Query: 535 GRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARA 594
R R++ +ERE R+ ER + RER E R R
Sbjct: 388 SRDRERERERE-----------------------RERERERERERERERERERERERERE 424
Query: 595 SFHVREKVREETNTRSFDRMVREAQL 620
+++ REE +++R E +L
Sbjct: 425 REKDKKRDREEDEEDAYERRKLERKL 450
Score = 55.5 bits (132), Expect = 1e-07
Identities = 53/210 (25%), Positives = 91/210 (43%), Gaps = 33/210 (15%)
Query: 365 RHQEELLLLEQRAAAHGQWELQRVHAK-QRREREEREK----QRALEQGRRAWAAQVEER 419
R +E E+ + E +R K ++R+REE E+ +R LE+ R A +ER
Sbjct: 401 REREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQER 460
Query: 420 RGRRGREEREAARRRQRQYERSEERRRELAERQGLLR----------------------- 456
ER+ R +++ ER EERRRE+A+ L+
Sbjct: 461 LKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQK 520
Query: 457 --RERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQ---RQE 511
R+R + ++R RK ++E+ + R+ L EG + + Q A R +Q +QE
Sbjct: 521 RLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQE 580
Query: 512 GQLQREKRELSRAERARHEALLQGRTRQQR 541
+ + E+ E E R E + + +Q+
Sbjct: 581 PESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
Score = 54.7 bits (130), Expect = 3e-07
Identities = 47/186 (25%), Positives = 82/186 (44%), Gaps = 12/186 (6%)
Query: 436 RQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQI 495
R+ + + ++L E +G +ER E +E R R+ ++E+ ++RE + RER +
Sbjct: 279 REISKFRDTHKKLEEEKGKKEKERQE-IEKERRERERERERERERREREREREREREREK 337
Query: 496 RRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRS-SLEAS 554
+ER +E + R++ +R R + R R++ +R RS S E S
Sbjct: 338 EKER---------ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKS 388
Query: 555 LGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREET-NTRSFDR 613
R +E R+ ER + RER E R + RE+ E+ R +R
Sbjct: 389 RDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLER 448
Query: 614 MVREAQ 619
+RE +
Sbjct: 449 KLREKE 454
Score = 34.7 bits (78), Expect = 0.27
Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 11/85 (12%)
Query: 353 ERDRKIAALMLARHQEELLLLEQRAAAHGQ----WELQRVHAKQRREREEREKQRALEQG 408
ERDRK R +EEL + QR A G ELQR+ + R R+ + KQ +
Sbjct: 533 ERDRK-------REKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEE 585
Query: 409 RRAWAAQVEERRGRRGREEREAARR 433
+ EE+R EE E ++
Sbjct: 586 EEEEKQEKEEKREEPMEEEEEPEQK 610
>gi|219803769 trichoplein [Homo sapiens]
Length = 498
Score = 74.3 bits (181), Expect = 3e-13
Identities = 89/332 (26%), Positives = 145/332 (43%), Gaps = 57/332 (17%)
Query: 318 RSFSLGDLSHSPQTA--------QHVERIVRQVRAERGLRGVPERDRKIAALM------L 363
R F + D+ S Q + + R+ E R + R K+ LM L
Sbjct: 39 RYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLL 98
Query: 364 ARHQEELLL---LEQRAAAHGQWELQRVHAKQRREREE--------------REKQRALE 406
AR EEL L L++R +L+ +QR+ E RE + L
Sbjct: 99 ARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLH 158
Query: 407 QGR--RAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAA 464
Q +W Q EE++ + E+E +R + +YER+ RRE ER + ER
Sbjct: 159 QKHVVNSWEMQKEEKKQQEATAEQEN-KRYENEYERA---RREALERM----KAEEERRQ 210
Query: 465 REDRLRK---LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKREL 521
ED+L+ LQQ + LK +E + ++ E + ++R + ++R++ + R+K EL
Sbjct: 211 LEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAEL 270
Query: 522 SRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-HLA-----------IGR 569
R R ++ A L RT+Q ++E E R L+A L + E+ HLA + +
Sbjct: 271 GRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQ 330
Query: 570 KLERSEQLTRERRSALES-ARSTARASFHVRE 600
+E QL R R + L+ R A+ + RE
Sbjct: 331 AIEEQLQLERAREAELQMLLREEAKEMWEKRE 362
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/256 (27%), Positives = 123/256 (48%), Gaps = 27/256 (10%)
Query: 341 QVRAERGLRGVPE-RDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
+++AE L+ + E + +++ A L + QE LL +QR WEL+R+ ++++ R
Sbjct: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLL--KQR------WELERLEEERKQMEAFR 265
Query: 400 EKQRALEQGRRAWAAQVEERRGRRGREEREAARR-RQRQYERSEERRR-ELAERQGLLRR 457
+K R + AQ+ RR ++ +EE EA RR Q E+ +E +R LA R+ ++
Sbjct: 266 QKAELGRFLRHQYNAQLS-RRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMAD 324
Query: 458 ERAERAAREDRL---RKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQL 514
+ A E++L R + E + REE + +R + RER+ R + G+
Sbjct: 325 VAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQ 384
Query: 515 QREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE---ASLGRAQENYEHLAIGRKL 571
Q+ + ++ + RA+ E+L + RE L +LE R +E E L RK
Sbjct: 385 QQIQEKIEQNRRAQEESL---------KHREQLIRNLEEVRELARREKEESEKLKSARKQ 435
Query: 572 ERSEQLTRERRSALES 587
E Q+ R A E+
Sbjct: 436 ELEAQVAERRLQAWEA 451
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/215 (26%), Positives = 98/215 (45%), Gaps = 30/215 (13%)
Query: 327 HSPQTAQHVERIVRQVRAERG-LRGVPERDRKIAALMLARHQ-------------EELLL 372
++ Q ++ ++I ++ A+R L+ + E++ + L LAR + EE L
Sbjct: 278 YNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337
Query: 373 LEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR 432
LE+ A Q L R AK+ E+ E E R R ++V R ++ +E+ E R
Sbjct: 338 LERAREAELQM-LLREEAKEMWEKREAEWARE-RSARDRLMSEVLTGRQQQIQEKIEQNR 395
Query: 433 RRQRQ-YERSEERRRELAERQGLLRRERAE----RAAREDRLRKLQQEQNLKQREEGLQE 487
R Q + + E+ R L E + L RRE+ E ++AR+ L E+ L+ E
Sbjct: 396 RAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWE----- 450
Query: 488 GRERAEQIRRERAQRAARAKQRQEGQLQREKRELS 522
A+Q E + A R +Q + LQ+E ++
Sbjct: 451 ----ADQQEEEEEEEARRVEQLSDALLQQEAETMA 481
Score = 37.0 bits (84), Expect = 0.055
Identities = 39/220 (17%), Positives = 98/220 (44%), Gaps = 19/220 (8%)
Query: 412 WAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRK 471
W +Q +R ++ +RE R ++Q+E++ R +++ + E + + + + +
Sbjct: 10 WCSQ--QRLNQQLARQREQEARLRQQWEQNSRYFR-MSDICSSKQAEWSSKTSYQRSMHA 66
Query: 472 LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR-------QEGQLQREKRELSRA 524
Q+E+ +++ L+ RE+ Q+ +E AR + QE +++ + +L A
Sbjct: 67 YQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSA 126
Query: 525 ERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSA 584
+ + + + + + ++ +E L + +H+ ++++ E+ +E +
Sbjct: 127 KEEQRKLIAEQLLYEHWKKNNPKLREMELDL-----HQKHVVNSWEMQKEEKKQQEATAE 181
Query: 585 LESAR---STARASFHVREKVREETNTRSF-DRMVREAQL 620
E+ R RA E+++ E R D++ EA L
Sbjct: 182 QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALL 221
Score = 35.8 bits (81), Expect = 0.12
Identities = 36/122 (29%), Positives = 55/122 (45%), Gaps = 19/122 (15%)
Query: 354 RDRKIAALMLARHQEELLLLEQRAAAHGQW---------ELQRVHAKQRREREEREKQRA 404
RDR ++ ++ R Q+ +EQ A + L+ V RRE+EE EK ++
Sbjct: 372 RDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKS 431
Query: 405 LEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAA 464
++ AQV ERR +A Q++ E EE RR LL++E AE A
Sbjct: 432 AR--KQELEAQVAERR-------LQAWEADQQEEEEEEEARRVEQLSDALLQQE-AETMA 481
Query: 465 RE 466
+
Sbjct: 482 EQ 483
>gi|14150056 trichoplein [Homo sapiens]
Length = 498
Score = 74.3 bits (181), Expect = 3e-13
Identities = 89/332 (26%), Positives = 145/332 (43%), Gaps = 57/332 (17%)
Query: 318 RSFSLGDLSHSPQTA--------QHVERIVRQVRAERGLRGVPERDRKIAALM------L 363
R F + D+ S Q + + R+ E R + R K+ LM L
Sbjct: 39 RYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLL 98
Query: 364 ARHQEELLL---LEQRAAAHGQWELQRVHAKQRREREE--------------REKQRALE 406
AR EEL L L++R +L+ +QR+ E RE + L
Sbjct: 99 ARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLH 158
Query: 407 QGR--RAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAA 464
Q +W Q EE++ + E+E +R + +YER+ RRE ER + ER
Sbjct: 159 QKHVVNSWEMQKEEKKQQEATAEQEN-KRYENEYERA---RREALERM----KAEEERRQ 210
Query: 465 REDRLRK---LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKREL 521
ED+L+ LQQ + LK +E + ++ E + ++R + ++R++ + R+K EL
Sbjct: 211 LEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAEL 270
Query: 522 SRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-HLA-----------IGR 569
R R ++ A L RT+Q ++E E R L+A L + E+ HLA + +
Sbjct: 271 GRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQ 330
Query: 570 KLERSEQLTRERRSALES-ARSTARASFHVRE 600
+E QL R R + L+ R A+ + RE
Sbjct: 331 AIEEQLQLERAREAELQMLLREEAKEMWEKRE 362
Score = 61.2 bits (147), Expect = 3e-09
Identities = 71/256 (27%), Positives = 123/256 (48%), Gaps = 27/256 (10%)
Query: 341 QVRAERGLRGVPE-RDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
+++AE L+ + E + +++ A L + QE LL +QR WEL+R+ ++++ R
Sbjct: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLL--KQR------WELERLEEERKQMEAFR 265
Query: 400 EKQRALEQGRRAWAAQVEERRGRRGREEREAARR-RQRQYERSEERRR-ELAERQGLLRR 457
+K R + AQ+ RR ++ +EE EA RR Q E+ +E +R LA R+ ++
Sbjct: 266 QKAELGRFLRHQYNAQLS-RRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMAD 324
Query: 458 ERAERAAREDRL---RKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQL 514
+ A E++L R + E + REE + +R + RER+ R + G+
Sbjct: 325 VAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQ 384
Query: 515 QREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE---ASLGRAQENYEHLAIGRKL 571
Q+ + ++ + RA+ E+L + RE L +LE R +E E L RK
Sbjct: 385 QQIQEKIEQNRRAQEESL---------KHREQLIRNLEEVRELARREKEESEKLKSARKQ 435
Query: 572 ERSEQLTRERRSALES 587
E Q+ R A E+
Sbjct: 436 ELEAQVAERRLQAWEA 451
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/215 (26%), Positives = 98/215 (45%), Gaps = 30/215 (13%)
Query: 327 HSPQTAQHVERIVRQVRAERG-LRGVPERDRKIAALMLARHQ-------------EELLL 372
++ Q ++ ++I ++ A+R L+ + E++ + L LAR + EE L
Sbjct: 278 YNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337
Query: 373 LEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR 432
LE+ A Q L R AK+ E+ E E R R ++V R ++ +E+ E R
Sbjct: 338 LERAREAELQM-LLREEAKEMWEKREAEWARE-RSARDRLMSEVLTGRQQQIQEKIEQNR 395
Query: 433 RRQRQ-YERSEERRRELAERQGLLRRERAE----RAAREDRLRKLQQEQNLKQREEGLQE 487
R Q + + E+ R L E + L RRE+ E ++AR+ L E+ L+ E
Sbjct: 396 RAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWE----- 450
Query: 488 GRERAEQIRRERAQRAARAKQRQEGQLQREKRELS 522
A+Q E + A R +Q + LQ+E ++
Sbjct: 451 ----ADQQEEEEEEEARRVEQLSDALLQQEAETMA 481
Score = 37.0 bits (84), Expect = 0.055
Identities = 39/220 (17%), Positives = 98/220 (44%), Gaps = 19/220 (8%)
Query: 412 WAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRK 471
W +Q +R ++ +RE R ++Q+E++ R +++ + E + + + + +
Sbjct: 10 WCSQ--QRLNQQLARQREQEARLRQQWEQNSRYFR-MSDICSSKQAEWSSKTSYQRSMHA 66
Query: 472 LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR-------QEGQLQREKRELSRA 524
Q+E+ +++ L+ RE+ Q+ +E AR + QE +++ + +L A
Sbjct: 67 YQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSA 126
Query: 525 ERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSA 584
+ + + + + + ++ +E L + +H+ ++++ E+ +E +
Sbjct: 127 KEEQRKLIAEQLLYEHWKKNNPKLREMELDL-----HQKHVVNSWEMQKEEKKQQEATAE 181
Query: 585 LESAR---STARASFHVREKVREETNTRSF-DRMVREAQL 620
E+ R RA E+++ E R D++ EA L
Sbjct: 182 QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALL 221
Score = 35.8 bits (81), Expect = 0.12
Identities = 36/122 (29%), Positives = 55/122 (45%), Gaps = 19/122 (15%)
Query: 354 RDRKIAALMLARHQEELLLLEQRAAAHGQW---------ELQRVHAKQRREREEREKQRA 404
RDR ++ ++ R Q+ +EQ A + L+ V RRE+EE EK ++
Sbjct: 372 RDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKS 431
Query: 405 LEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAA 464
++ AQV ERR +A Q++ E EE RR LL++E AE A
Sbjct: 432 AR--KQELEAQVAERR-------LQAWEADQQEEEEEEEARRVEQLSDALLQQE-AETMA 481
Query: 465 RE 466
+
Sbjct: 482 EQ 483
>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
[Homo sapiens]
Length = 213
Score = 72.8 bits (177), Expect = 9e-13
Identities = 53/194 (27%), Positives = 87/194 (44%), Gaps = 5/194 (2%)
Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA- 449
++RR +RE+ RA E ++ + +R R ER+ R R++Q +R ER+RE
Sbjct: 21 RERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRERER 80
Query: 450 --ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
+RQ RER + + ++ Q K+RE RER +Q R ++ R
Sbjct: 81 DRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDRET 140
Query: 508 QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAI 567
R+ + +RE R + E + R R++++ERE R + E E
Sbjct: 141 DRERERQAERERETGRERKT--EDRHRERERERKRERERKRETKERERHTDMERERQRET 198
Query: 568 GRKLERSEQLTRER 581
RK +R + RER
Sbjct: 199 DRKRDRQRESERER 212
Score = 63.9 bits (154), Expect = 4e-10
Identities = 57/214 (26%), Positives = 92/214 (42%), Gaps = 13/214 (6%)
Query: 334 HVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQR 393
H E + ER ERDR + RH E +++ E R +++
Sbjct: 11 HTETETMDRQRERRRETDRERDRAKESKTEDRHSER----DRQRDRERNRERDRDREREK 66
Query: 394 REREEREKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRRELAERQ 452
+ E E+QR E+ R +R R R+ ERE R + ER +++ RE+ ER
Sbjct: 67 QTDREGERQRERERDRD------RQRETERERDKERETDRHTETDRERQKQKEREM-ERV 119
Query: 453 GLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRER-AEQIRRERAQRAARAKQRQE 511
RE+ + RE + + + +Q E + GRER E RER + R ++R+
Sbjct: 120 RDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKR 179
Query: 512 GQLQREKRELSRAERARHEALLQGRTRQQRQERE 545
+RE+ ER R + R R+ +ER+
Sbjct: 180 ETKERERHTDMERERQRETDRKRDRQRESERERD 213
Score = 62.8 bits (151), Expect = 9e-10
Identities = 53/207 (25%), Positives = 87/207 (42%), Gaps = 23/207 (11%)
Query: 424 GREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREE 483
GR RQ ER E RE R+RA+ + EDR + ++++ ++R
Sbjct: 7 GRHTHTETETMDRQRERRRETDRE---------RDRAKESKTEDRHSERDRQRD-RERNR 56
Query: 484 GLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQE 543
RER +Q RE ++ R + R + Q + E+ E RH + R +Q+ +E
Sbjct: 57 ERDRDREREKQTDREGERQRERERDR-DRQRETERERDKERETDRHTETDRERQKQKERE 115
Query: 544 REGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTAR---ASFHVRE 600
E +R +E + +GR+ + + RER E R T R RE
Sbjct: 116 MERVRD---------REREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRE 166
Query: 601 KVREETNTRSFDRMVREAQLHASLDRK 627
+ RE R R +E + H ++R+
Sbjct: 167 RERERKRERERKRETKERERHTDMERE 193
Score = 55.5 bits (132), Expect = 1e-07
Identities = 63/236 (26%), Positives = 96/236 (40%), Gaps = 40/236 (16%)
Query: 389 HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRREL 448
H E +R+++R E R +R E+R + R RQR ER+ ER R+
Sbjct: 9 HTHTETETMDRQRERRRETDRE------RDRAKESKTEDRHSERDRQRDRERNRERDRD- 61
Query: 449 AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRER--AQRAARA 506
RER ++ RE +QRE + R+R + RER + R
Sbjct: 62 --------REREKQTDREGE----------RQRER--ERDRDRQRETERERDKERETDRH 101
Query: 507 KQRQEGQLQREKRELSRA-ERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHL 565
+ + ++++RE+ R +R R + GR RQ +E + R R E
Sbjct: 102 TETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERE-------RQAERERET 154
Query: 566 AIGRKLE-RSEQLTRERRSALESARSTARASFHV-REKVREETNTRSFDRMVREAQ 619
RK E R + RER+ E R T H E+ R+ R DR RE++
Sbjct: 155 GRERKTEDRHRERERERKRERERKRETKERERHTDMERERQRETDRKRDRQ-RESE 209
Score = 30.8 bits (68), Expect = 3.9
Identities = 28/114 (24%), Positives = 43/114 (37%), Gaps = 11/114 (9%)
Query: 517 EKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQ 576
E + R E + + R R++ +RE R+ + R E R +R +
Sbjct: 2 ESKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSE--------RDRQRDRE 53
Query: 577 LTRERRSALESARSTARASFHVREKVREETNTRSFDR---MVREAQLHASLDRK 627
RER E + T R RE+ R+ R +R RE H DR+
Sbjct: 54 RNRERDRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRE 107
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 72.4 bits (176), Expect = 1e-12
Identities = 58/198 (29%), Positives = 100/198 (50%), Gaps = 13/198 (6%)
Query: 363 LARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGR 422
L R +L Q + + E+QR ++++ ++E E++R + R ++E R
Sbjct: 120 LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERL--ERERMERERLERERLE 177
Query: 423 RGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE 482
R R ERE + Q + ER E R+E ERQ R ER ER R++RL + +QE+ ++R
Sbjct: 178 RERLERERLEQEQLERERQERERQERLERQE--RLERQERLERQERLDRERQERQERERL 235
Query: 483 EGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ 542
E L+ RER E+ R+E+ +R++ + +RE+R S A A E L
Sbjct: 236 ERLE--RERQERERQEQL-------EREQLEWERERRISSAAAPASVETPLNSVLGDSSA 286
Query: 543 EREGLRSSLEASLGRAQE 560
GL+++ + + +Q+
Sbjct: 287 SEPGLQAASQPAETPSQQ 304
Score = 53.9 bits (128), Expect = 4e-07
Identities = 47/151 (31%), Positives = 75/151 (49%), Gaps = 20/151 (13%)
Query: 473 QQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEAL 532
Q+E +++R+ LQE ++R +++ RER +R ++R L+RE+ E R ER R E
Sbjct: 137 QEELEIQRRQ--LQE-QQRQKELERERLERERMERER----LERERLERERLERERLEQE 189
Query: 533 LQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTA 592
R RQ+R+ +E L E E L +LER E+L RER+ E R
Sbjct: 190 QLERERQERERQERL------------ERQERLERQERLERQERLDRERQERQERER-LE 236
Query: 593 RASFHVREKVREETNTRSFDRMVREAQLHAS 623
R +E+ R+E R RE ++ ++
Sbjct: 237 RLERERQERERQEQLEREQLEWERERRISSA 267
Score = 52.0 bits (123), Expect = 2e-06
Identities = 50/165 (30%), Positives = 78/165 (47%), Gaps = 18/165 (10%)
Query: 466 EDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR------QEGQLQREKR 519
E + R+LQ++Q R++ L+ R E++ RER +R ++R ++ QL+RE++
Sbjct: 141 EIQRRQLQEQQ----RQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
Query: 520 ELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGR-KLERSEQLT 578
E R ER + L+ + R +RQE R E + +E E L R + ER EQL
Sbjct: 197 ERERQERLERQERLERQERLERQE----RLDRERQERQERERLERLERERQERERQEQLE 252
Query: 579 RERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHAS 623
RE+ LE R +S V N+ D E L A+
Sbjct: 253 REQ---LEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAA 294
Score = 38.1 bits (87), Expect = 0.025
Identities = 35/117 (29%), Positives = 56/117 (47%), Gaps = 5/117 (4%)
Query: 330 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 389
Q + +ER ++ ER R ER+R + E+ L +R Q L+R
Sbjct: 151 QRQKELER--ERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQE 208
Query: 390 AKQRREREEREKQRALEQGRRAWAAQVEE-RRGRRGREEREAARRRQRQYERSEERR 445
+R+ER ER+++ E+ R ++E R R+ RE +E R Q ++ER ERR
Sbjct: 209 RLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWER--ERR 263
Score = 35.8 bits (81), Expect = 0.12
Identities = 32/117 (27%), Positives = 47/117 (40%), Gaps = 20/117 (17%)
Query: 142 RSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAP- 200
R R+ E E ER +L++ R ERER + E+ +L ++AAA A+ P
Sbjct: 218 RQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPL 277
Query: 201 ------SAGSSSSCSSASLPA-------------SPAPRAARKASPSPSSARTQPPP 238
S+ S +AS PA +P P P+ +S PPP
Sbjct: 278 NSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPP 334
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.124 0.338
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,159,584
Number of Sequences: 37866
Number of extensions: 1260449
Number of successful extensions: 42410
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 831
Number of HSP's successfully gapped in prelim test: 1725
Number of HSP's that attempted gapping in prelim test: 15116
Number of HSP's gapped (non-prelim): 12851
length of query: 627
length of database: 18,247,518
effective HSP length: 108
effective length of query: 519
effective length of database: 14,157,990
effective search space: 7347996810
effective search space used: 7347996810
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.