Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 117968353
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|117968353 NUF2, NDC80 kinetochore complex component [Homo
sapiens]
(464 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|117968420 NUF2, NDC80 kinetochore complex component [Homo sap... 910 0.0
gi|117968353 NUF2, NDC80 kinetochore complex component [Homo sap... 910 0.0
gi|71061468 centromere protein E [Homo sapiens] 67 4e-11
gi|55770834 centromere protein F [Homo sapiens] 67 4e-11
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 65 2e-10
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 64 2e-10
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 64 2e-10
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 64 2e-10
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 64 4e-10
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 64 4e-10
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 63 6e-10
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 63 6e-10
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 62 8e-10
gi|38044112 restin isoform b [Homo sapiens] 61 2e-09
gi|4506751 restin isoform a [Homo sapiens] 61 2e-09
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 61 2e-09
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 61 2e-09
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 61 2e-09
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 60 3e-09
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 60 4e-09
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 60 4e-09
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 60 4e-09
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 60 4e-09
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 60 4e-09
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 60 4e-09
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 60 4e-09
gi|58530840 desmoplakin isoform I [Homo sapiens] 60 5e-09
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 60 5e-09
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 60 5e-09
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 59 7e-09
>gi|117968420 NUF2, NDC80 kinetochore complex component [Homo
sapiens]
Length = 464
Score = 910 bits (2353), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 1 METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIR 60
METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIR
Sbjct: 1 METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIR 60
Query: 61 LEHFYMMPVNSEVMYPHLMEGFLPFSNLVTHLDSFLPICRVNDFETADILCPKAKRTSRF 120
LEHFYMMPVNSEVMYPHLMEGFLPFSNLVTHLDSFLPICRVNDFETADILCPKAKRTSRF
Sbjct: 61 LEHFYMMPVNSEVMYPHLMEGFLPFSNLVTHLDSFLPICRVNDFETADILCPKAKRTSRF 120
Query: 121 LSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF 180
LSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF
Sbjct: 121 LSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF 180
Query: 181 KQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESL 240
KQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESL
Sbjct: 181 KQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESL 240
Query: 241 KTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKI 300
KTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKI
Sbjct: 241 KTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKI 300
Query: 301 QDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKIN 360
QDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKIN
Sbjct: 301 QDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKIN 360
Query: 361 KKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQ 420
KKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQ
Sbjct: 361 KKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQ 420
Query: 421 EIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMST 464
EIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMST
Sbjct: 421 EIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMST 464
>gi|117968353 NUF2, NDC80 kinetochore complex component [Homo
sapiens]
Length = 464
Score = 910 bits (2353), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 1 METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIR 60
METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIR
Sbjct: 1 METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIR 60
Query: 61 LEHFYMMPVNSEVMYPHLMEGFLPFSNLVTHLDSFLPICRVNDFETADILCPKAKRTSRF 120
LEHFYMMPVNSEVMYPHLMEGFLPFSNLVTHLDSFLPICRVNDFETADILCPKAKRTSRF
Sbjct: 61 LEHFYMMPVNSEVMYPHLMEGFLPFSNLVTHLDSFLPICRVNDFETADILCPKAKRTSRF 120
Query: 121 LSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF 180
LSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF
Sbjct: 121 LSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF 180
Query: 181 KQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESL 240
KQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESL
Sbjct: 181 KQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESL 240
Query: 241 KTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKI 300
KTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKI
Sbjct: 241 KTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKI 300
Query: 301 QDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKIN 360
QDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKIN
Sbjct: 301 QDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKIN 360
Query: 361 KKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQ 420
KKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQ
Sbjct: 361 KKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQ 420
Query: 421 EIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMST 464
EIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMST
Sbjct: 421 EIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMST 464
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 66.6 bits (161), Expect = 4e-11
Identities = 92/402 (22%), Positives = 171/402 (42%), Gaps = 76/402 (18%)
Query: 128 IHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGI 187
+H E ET EF Q DK Q L A + + L + D+ +E+Q + L
Sbjct: 995 LHMEENTGETKDEFQ-QKMVGIDKKQDLEAKNTQTLTA-DVKDNEIIEQQRKIFSLIQEK 1052
Query: 188 QELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKT----- 242
ELQQ L +K ++ + K NI + EL+L LK+ QE +
Sbjct: 1053 NELQQMLESVIAEK----EQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHA 1108
Query: 243 ------------KIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDC---LP 287
++ + EKLK +++++ Q+L N ++E+ E + + + L
Sbjct: 1109 IKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELK 1168
Query: 288 SCQLEVQLYQKK----IQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKR 343
+ +L ++ + + Q L++N E++ SI KE L++ +S E+E L+ +
Sbjct: 1169 NKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEA 1228
Query: 344 LMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDC-------------NKVQEKRGAVYE- 389
+ KE+L A + + E + + +R+V E K+QE+ ++E
Sbjct: 1229 TGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEE 1288
Query: 390 --------RVTTINQEIQKIKLGIQQ--LKDAA-----EREKLKSQEIFL---------- 424
V+ + + +++L +Q KD+ E E+L+ E F
Sbjct: 1289 QELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLT 1348
Query: 425 ----NLKT---ALEKYHDGIEKAAEDSYAKIDEKTAELKRKM 459
NLKT ALE HD +++ ++ AKI E ++ ++ +
Sbjct: 1349 KERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSL 1390
Score = 66.2 bits (160), Expect = 6e-11
Identities = 83/369 (22%), Positives = 156/369 (42%), Gaps = 48/369 (13%)
Query: 126 NFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVP--VEEQEEFKQ- 182
N +EA + + + + K+Q+ + +++L E+ + V E E+FK
Sbjct: 1353 NLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPK 1412
Query: 183 -------------LSDGIQELQQSLNQ------DFHQKTIVLQEGNSQKKSNISE-KTKR 222
LS +QE + D + VLQ + Q K NI E K
Sbjct: 1413 DSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH 1472
Query: 223 LN---ELKLSVVSLKEIQESLKTKIVDSPEK---LKNYKEKMKDTVQKLKNARQEVVEKY 276
L ELK++ LKE +E++ V+ EK + +++++ KL+N QE+ EK
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKE 1532
Query: 277 EIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKT 336
E + ++ Q+K+ +L +E K + IES EL
Sbjct: 1533 EQFNIK---------QISEVQEKVNELKQFKEHR----KAKDSALQSIESKMLELTNRLQ 1579
Query: 337 EENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQ 396
E ++MI +KE++ Q + + + +K+ + ++ + QEK + ++T +N
Sbjct: 1580 ESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKE-YQFLKMTAVN- 1637
Query: 397 EIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAKID----EKT 452
E Q+ I+ LK+ E +KL + I + H+ +E+ + + D E+T
Sbjct: 1638 ETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEET 1697
Query: 453 AELKRKMFK 461
+++R K
Sbjct: 1698 LKVERDQLK 1706
Score = 64.3 bits (155), Expect = 2e-10
Identities = 78/338 (23%), Positives = 149/338 (44%), Gaps = 38/338 (11%)
Query: 155 LNAAHQEALMKLERLDSVPVEEQE---EFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQ 211
L A E K + L E QE E +QL + ++ +L +KT++ ++ Q
Sbjct: 861 LGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEK-LQQ 919
Query: 212 KKSNISEKTKRLNELKLSVVSLKEIQESLKTKI-------VDSPEKLKNYKEKMK---DT 261
+ T+ ++LK SL+ ++ LK+ I +D+ E+L+N E +K +T
Sbjct: 920 TLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQET 979
Query: 262 VQKLKNARQEVVE------------KYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDN--- 306
+ LK+ E V K E V LE + Q D+ DN
Sbjct: 980 INTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039
Query: 307 --REKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHE 364
+ K+ S+++E L+ +ES +E ++LKT+ + I +E+L ++ K+ E
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQE 1099
Query: 365 DVKQYKRTVIE---DCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQE 421
V Q K I+ + ++ ++ V E++ +Q++Q+ + + +++ + K E
Sbjct: 1100 IVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINE 1159
Query: 422 IFLNLKTALEKYH---DGIEKAAEDSYAKIDEKTAELK 456
I NLK L+ + +E + K++E E+K
Sbjct: 1160 I-ENLKNELKNKELTLEHMETERLELAQKLNENYEEVK 1196
Score = 60.8 bits (146), Expect = 2e-09
Identities = 86/375 (22%), Positives = 161/375 (42%), Gaps = 76/375 (20%)
Query: 131 REACRETYMEFLWQYKSSADKMQQ---LNAAH--QEALMKLERL-----------DSVPV 174
R+ +E E + + K S +K Q + A + QE + ++E L +++
Sbjct: 1606 RDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIET 1665
Query: 175 EEQEEFKQLSDGIQELQQSLNQ--DFHQKTIVLQEGNSQKKSNISEKTKR----LNELKL 228
E + L + ++E++ + D L+ Q K N+ E R ELK+
Sbjct: 1666 ENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKI 1725
Query: 229 SVVSLKEIQES---LKTKIVDSPEKLKNYKEKMKDTVQKLK-----------------NA 268
+ LKE QE+ L+ + + ++ N ++ ++ + LK
Sbjct: 1726 VHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKE 1785
Query: 269 RQEVVEKYE-IYGDSVDCLPSCQLEVQ----LYQKKIQDLSDNREKLASILKESLNLEDQ 323
+QE ++K I + D L + Q +++ Q+KIQ+L N +L ++ K+ + +
Sbjct: 1786 QQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKK 1845
Query: 324 IESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEK 383
+ E K++K + + +L I E L AQ K HE++++ K + E N
Sbjct: 1846 VSEMEQLKKQIKDQSLTLSKLEI---ENLNLAQ----KLHENLEEMKSVMKERDN----- 1893
Query: 384 RGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTA--LEKYH-DGIEKA 440
+ + + +KL QLK++ + K + EI LKTA L K H + ++K
Sbjct: 1894 ----------LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKL 1943
Query: 441 AEDSYAKIDEKTAEL 455
E KI EKT ++
Sbjct: 1944 RE----KISEKTIQI 1954
Score = 60.5 bits (145), Expect = 3e-09
Identities = 81/335 (24%), Positives = 146/335 (43%), Gaps = 35/335 (10%)
Query: 153 QQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQK 212
+QL A + + K++ + EEQ KQ+S+ +QE L Q F +
Sbjct: 1512 KQLEAINDKLQNKIQEI--YEKEEQFNIKQISE-VQEKVNELKQ-FKEHRKAKDSALQSI 1567
Query: 213 KSNISEKTKRLNELKLSV-VSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQE 271
+S + E T RL E + + + +KE +E + + E+ KE K+ V K+K ++++
Sbjct: 1568 ESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIER-DQLKENTKEIVAKMKESQEK 1626
Query: 272 VVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLS-DNRE----KLASILKESLNLEDQIES 326
+ ++ + C++E Q + Q L+ +N E +L IL E+L +++ S
Sbjct: 1627 EYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENL---EEMRS 1683
Query: 327 DESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGA 386
E L++ E + K KE L + +K E++K + E + + RG
Sbjct: 1684 VTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGI 1743
Query: 387 VYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQE----IFLNLKTALEKYH-------- 434
V E+ EI ++ ++ DA + + LK QE ++LK E
Sbjct: 1744 VSEKTN----EISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSE 1799
Query: 435 -----DGIEKAAEDSYAKIDEKTAELKRKMFKMST 464
++K E+S AK+ EK ELK ++ T
Sbjct: 1800 KTDKLSNMQKDLENSNAKLQEKIQELKANEHQLIT 1834
Score = 50.8 bits (120), Expect = 3e-06
Identities = 69/329 (20%), Positives = 150/329 (45%), Gaps = 39/329 (11%)
Query: 150 DKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSL------NQDFHQKTI 203
+K+Q+L A ++ L+ L++ + ++ E +QL I++ +L N + QK
Sbjct: 1820 EKIQELKA-NEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQK-- 1876
Query: 204 VLQEGNSQKKSNISEKT--KRLNE-LKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKD 260
L E + KS + E+ +R+ E LKL LKE + K + ++ ++LK + K+
Sbjct: 1877 -LHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKE 1935
Query: 261 TVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNL 320
+ + R+++ EK D L + E+ QKKIQ+L +L + KE +N+
Sbjct: 1936 HKETVDKLREKISEKTIQISDIQKDLDKSKDEL---QKKIQELQKKELQLLRV-KEDVNM 1991
Query: 321 EDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKK-HEDVKQYK--------- 370
+ ++ +LKK +N + + + F++ KK HE +++ +
Sbjct: 1992 SHKKINEMEQLKKQFEAQN-------LSMQSVRMDNFQLTKKLHESLEEIRIVAKERDEL 2044
Query: 371 RTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTAL 430
R + E +++ A + +++ ++K + L D + +E +K L
Sbjct: 2045 RRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELL 2104
Query: 431 EKYHDGIEKAAEDSYAKIDEKTAELKRKM 459
++Y + +D Y ++ + +L++++
Sbjct: 2105 KRYSE-----MDDHYECLNRLSLDLEKEI 2128
Score = 49.7 bits (117), Expect = 6e-06
Identities = 72/347 (20%), Positives = 144/347 (41%), Gaps = 54/347 (15%)
Query: 145 YKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIV 204
YKS+ + Q H + K + + +E LS Q+ SL
Sbjct: 812 YKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLG--------A 863
Query: 205 LQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQK 264
L+ S K + EKT+ + E + LKE E+ + + + EK++ T+++
Sbjct: 864 LKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEE 923
Query: 265 LKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDL----SDNREKLASILKESLNL 320
+K QE D S Q+E + I D D +E+L + L+
Sbjct: 924 VKTLTQE-------KDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQH 976
Query: 321 EDQIESDESEL-----KKLKTEENS------FKRLMI---------VKKEKLATAQFKIN 360
++ I + +S++ + L EEN+ F++ M+ K + TA K N
Sbjct: 977 QETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDN 1036
Query: 361 KKHEDVKQYKR--TVIEDCNKVQEKRGAVYERVTTINQEIQ-KIKLGIQQLKDAAEREKL 417
E ++Q ++ ++I++ N++Q+ + E V ++++ +K I+ + E +L
Sbjct: 1037 ---EIIEQQRKIFSLIQEKNELQQ----MLESVIAEKEQLKTDLKENIEMTIENQEELRL 1089
Query: 418 KSQEIFLNLKTALEKYHDGIEKAAE-----DSYAKIDEKTAELKRKM 459
E+ + ++ + I+K E D A+++EK E +++
Sbjct: 1090 LGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQL 1136
Score = 44.7 bits (104), Expect = 2e-04
Identities = 56/290 (19%), Positives = 128/290 (44%), Gaps = 37/290 (12%)
Query: 150 DKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGN 209
+K + N A +E ++ L L S+P E + K++ D +EL ++
Sbjct: 730 NKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELH------------IITSEK 777
Query: 210 SQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYK-------EKMKDTV 262
+ S + K R+ L + K+ + ++ + ++ +N+K +K K +
Sbjct: 778 DKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVL 837
Query: 263 QKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLED 322
++ + QE+V + L + + E+ K Q+L + ++ L E L++
Sbjct: 838 EENERMNQEIVNLSKEAQKFDSSLGALKTELSY---KTQELQEKTREVQERLNEMEQLKE 894
Query: 323 QIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQE 382
Q+E+ +S L+ ++ E K L+ K ++ + ++ +D+KQ + ++ + ++++
Sbjct: 895 QLENRDSTLQTVERE----KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKS 950
Query: 383 KRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEK 432
+ T+N I +QL++A E K + QE LK+ + +
Sbjct: 951 ------DIHDTVNMNIDT----QEQLRNALESLK-QHQETINTLKSKISE 989
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 66.6 bits (161), Expect = 4e-11
Identities = 75/319 (23%), Positives = 149/319 (46%), Gaps = 40/319 (12%)
Query: 147 SSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQ 206
S D ++ L ++++ +LE + E+ +++ ELQ+ +++ QKT LQ
Sbjct: 2578 SLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHE-MAQKTAELQ 2636
Query: 207 EGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLK 266
E S EK + EL+L + +K ++ LK +++ E K+ KD V+K
Sbjct: 2637 EELS------GEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEG 2690
Query: 267 NARQEVVEKYEI---------YGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKES 317
R+E+ E Y++ +D ++E+Q Y++K L+ E L+S +
Sbjct: 2691 KVREEIAE-YQLRLHEAEKKHQALLLDTNKQYEVEIQTYREK---LTSKEECLSS---QK 2743
Query: 318 LNLEDQIESDESEL-KKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIED 376
L + D ++S + EL LK + L K + L ++ K++E + + +I+
Sbjct: 2744 LEI-DLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVN-QLKKENERAQGKMKLLIKS 2801
Query: 377 CNKVQEKRGAVYERVTTINQEIQKIKLG-------------IQQLKDAAEREKLKSQEIF 423
C +++E++ + + ++ + +K K G I++LK+ E EK K + +
Sbjct: 2802 CKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLE-EKTKEADEY 2860
Query: 424 LNLKTALEKYHDGIEKAAE 442
L+ +L H+ +EKA E
Sbjct: 2861 LDKYCSLLISHEKLEKAKE 2879
Score = 55.8 bits (133), Expect = 8e-08
Identities = 64/288 (22%), Positives = 125/288 (43%), Gaps = 35/288 (12%)
Query: 147 SSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQ 206
SS + QL A +QE K+ L+ ++E K + QELQ L +
Sbjct: 275 SSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEK---------- 324
Query: 207 EGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLK 266
K + EK K LN+ + +V + TK +KLK E + Q +
Sbjct: 325 -----AKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAE 379
Query: 267 NAR----QEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLED 322
+AR Q++ EK + + + + + + +Q Q+ + +L L+++ N+ +
Sbjct: 380 SARCSLEQKIKEKEKEFQEEL------SRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433
Query: 323 QIESDESELKKLKTE-ENS---FKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCN 378
++++ +L +K + EN+ FK+ + ++ +Q K N+ +++ K+ + N
Sbjct: 434 VLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKK----ENN 489
Query: 379 KVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLK--SQEIFL 424
++ V + E++ IK + Q ++ AE K K SQE L
Sbjct: 490 LLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML 537
Score = 53.1 bits (126), Expect = 5e-07
Identities = 64/318 (20%), Positives = 137/318 (43%), Gaps = 25/318 (7%)
Query: 149 ADKMQQLNAAHQEALMKLERLDSVPVE-----EQEEFKQLSDGIQELQQSLNQDFHQKTI 203
++K++ + HQE L ++E + + + ++ + + D + ++ S + F
Sbjct: 1843 SEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVEN 1902
Query: 204 VLQEGNSQKKSNISEKT---KRLNELKLSVVSLKEIQESLKTKIVDSPEKL------KNY 254
L S+K S E L ++ + L++ E+ + IV E+L +N
Sbjct: 1903 ELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQ 1962
Query: 255 KEKMKDTVQKLKNARQEVVEKY-----EIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREK 309
DT+ K A ++ EK E+ +CL Q+ ++K + L
Sbjct: 1963 LRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSD 2022
Query: 310 LASILKESLNLEDQIES---DESELKKLKTE-ENSFKRLMIVKKEKLATAQFKINKKHED 365
++ +LK+ +L+++++S D L K E EN +L +KE L + + +
Sbjct: 2023 VSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLN-KEKELLVKESESLQARLSE 2081
Query: 366 VKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLN 425
K V + ++G R+++ +E+ +++ GI++L+ E ++ K I
Sbjct: 2082 SDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEK 2141
Query: 426 LKTALEKYHDGIEKAAED 443
LK E+ +D ++ E+
Sbjct: 2142 LKER-ERENDSLKDKVEN 2158
Score = 46.2 bits (108), Expect = 6e-05
Identities = 60/321 (18%), Positives = 130/321 (40%), Gaps = 47/321 (14%)
Query: 140 EFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQ-------LSDGIQELQQ 192
EF + S+ +++ QL ++ +++E + + E+ K+ L D ++ L++
Sbjct: 2102 EFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLER 2161
Query: 193 SLNQDFHQKTIVLQEGNSQK------KSNISEKTKRLNELKLSVVSLKEIQESLKTKIVD 246
L + +V+ + + K K+ I E + L +L +V+L+ +E+L +I +
Sbjct: 2162 ELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQE 2221
Query: 247 SPEKLKNY---------------------KEKMKDTVQKLKNARQEVVEKYEIYGDSVDC 285
+L KE+ K V+ L+N +E+ E +
Sbjct: 2222 KQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEI 2281
Query: 286 LPSCQLEVQLYQKKIQDLSDNREKLASIL----KESLNLEDQIESDESELKKLKTEENSF 341
+ + + + ++ L ++ EKL + L K+ L + Q++ E LK +
Sbjct: 2282 MKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENL 2341
Query: 342 KRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKI 401
+R + + + A + +V+ K + Q RG + V TI E + +
Sbjct: 2342 ERELEIARTNQEHAALEAENSKGEVETLKAKIE---GMTQSLRGLELD-VVTIRSEKENL 2397
Query: 402 KLGIQQLKDAAEREKLKSQEI 422
+Q+ E+E++ EI
Sbjct: 2398 TNELQK-----EQERISELEI 2413
Score = 45.8 bits (107), Expect = 8e-05
Identities = 66/320 (20%), Positives = 130/320 (40%), Gaps = 63/320 (19%)
Query: 167 ERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNEL 226
E L + +EQE +L + I +++ Q+ Q+ + ++E +S + + K LNE
Sbjct: 2395 ENLTNELQKEQERISEL-EIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNE- 2452
Query: 227 KLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCL 286
V +L QE+ K K + L + E ++ +L E Y + SV+ L
Sbjct: 2453 --RVAALHNDQEACKAK----EQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGL 2506
Query: 287 PSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKL----------KT 336
IQ++ D ++KL +E L++QI+ E + KL K
Sbjct: 2507 -------------IQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKE 2553
Query: 337 EENSFKRLMIVKKEKLATAQFK-----------------INKKHEDVKQYKRTVIEDCNK 379
+ + L + ++K+ Q K + + E K K + +E NK
Sbjct: 2554 QNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613
Query: 380 VQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDGIEK 439
+ K T + +E+ ++ +L++ EK + L+ LE+ K
Sbjct: 2614 MTAKE-------TELQREMHEMAQKTAELQEELSGEK---NRLAGELQLLLEEI-----K 2658
Query: 440 AAEDSYAKIDEKTAELKRKM 459
+++D ++ + +ELK+ +
Sbjct: 2659 SSKDQLKELTLENSELKKSL 2678
Score = 43.9 bits (102), Expect = 3e-04
Identities = 75/305 (24%), Positives = 135/305 (44%), Gaps = 38/305 (12%)
Query: 155 LNAAHQEALMKLERLDSVPVEEQEEFKQLSDG--------IQELQQSLN--QDFHQKTIV 204
LN + K E + E ++ +LSD +Q +++ N +D QK
Sbjct: 986 LNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKA 1045
Query: 205 LQEGNSQKKSNISEKT----KRLNEL-KLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMK 259
QE NS+ + ++E T R NEL +L KE QE L TK+ + E+ +N +++
Sbjct: 1046 AQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFL-TKLAFAEERNQNLMLELE 1104
Query: 260 DTVQKLKN--ARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILK-- 315
Q L++ + K E G + + + + E QK++ DL E+L ++K
Sbjct: 1105 TVQQALRSEMTDNQNNSKSEAGGLKQEIM-TLKEEQNKMQKEVNDLLQENEQLMKVMKTK 1163
Query: 316 -ESLNLEDQIESDESELKKLKTEEN--SFKRLMIVKKEKLATAQFKIN-KKHEDVKQYKR 371
E NLE E + +K+ ++E N +FK M ++ ++++ + + E + + K
Sbjct: 1164 HECQNLES--EPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKE 1221
Query: 372 TVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALE 431
+++ K +E + + TI +++ L Q + E LK EI A E
Sbjct: 1222 LKLQESEKEKE---CLQHELQTIRGDLETSNL---QDMQSQEISGLKDCEI-----DAEE 1270
Query: 432 KYHDG 436
KY G
Sbjct: 1271 KYISG 1275
Score = 43.9 bits (102), Expect = 3e-04
Identities = 62/322 (19%), Positives = 139/322 (43%), Gaps = 42/322 (13%)
Query: 144 QYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTI 203
+ K + +Q L++ E L L +++ + LS EL+ + Q +K +
Sbjct: 2008 EVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKEL 2067
Query: 204 VLQEGNS---------QKKSNIS-----------EKTKRLNELKLSVVSLKEIQESLKTK 243
+++E S +K N+S E RL+ + V L+ E L+ +
Sbjct: 2068 LVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVR 2127
Query: 244 IVDSPEKLKNYKEKMKDTVQ-------KLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLY 296
I +K + EK+K+ + K++N +E+ E + + + EV+
Sbjct: 2128 IEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETL 2187
Query: 297 QKKIQDLSDNRE----KLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKL 352
+ +I++++ + + L ++ E NL QI+ + +L +L +SFK L+ K++
Sbjct: 2188 KTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQ-- 2245
Query: 353 ATAQFKINKKHEDVKQYKRTVIEDCNKV-------QEKRGAVYERVTTINQEIQKIKLGI 405
A+ +I ++ + + + +++ N+ QE A + + +E +++ I
Sbjct: 2246 --AEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSI 2303
Query: 406 QQLKDAAEREKLKSQEIFLNLK 427
++L+ E ++ K + LK
Sbjct: 2304 EKLRARLEADEKKQLCVLQQLK 2325
Score = 43.1 bits (100), Expect = 5e-04
Identities = 66/324 (20%), Positives = 128/324 (39%), Gaps = 69/324 (21%)
Query: 145 YKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIV 204
+++S K +L + +E + L S ++ E L ++ ++Q LNQ + +
Sbjct: 467 FQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEM 526
Query: 205 LQEGNSQK--------KSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKE 256
+ SQ+ K N E + L +LKL+V L E
Sbjct: 527 KAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADL----------------------E 564
Query: 257 KMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKE 316
K +D Q L R+ +E+ +KL+ KE
Sbjct: 565 KQRDCSQDLLKKREHHIEQL------------------------------NDKLSKTEKE 594
Query: 317 SLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIED 376
S L +E + E ++LK E+ F + EKL T + ++ Q K +E
Sbjct: 595 SKALLSALELKKKEYEELKEEKTLFS-CWKSENEKLLTQM----ESEKENLQSKINHLET 649
Query: 377 CNKVQEKRGAVY-ERVTTINQEIQKIKLGIQQLKDAAERE--KLKSQEI-FLNLKTALEK 432
C K Q+ + Y ERV T+ + + + + I+ L + + + ++++Q++ ++ L+ E
Sbjct: 650 CLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEF 709
Query: 433 YHDGIEKAAEDSYAKIDEKTAELK 456
+K E+ K + T +++
Sbjct: 710 SDQKHQKEIENMCLKTSQLTGQVE 733
Score = 42.7 bits (99), Expect = 7e-04
Identities = 66/318 (20%), Positives = 128/318 (40%), Gaps = 23/318 (7%)
Query: 128 IHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGI 187
I+ E C +T +Y ++++ L + +++ L +V + E +
Sbjct: 644 INHLETCLKTQQIKSHEYN---ERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAY 700
Query: 188 QELQQS--LNQDFHQKTIV-LQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKI 244
ELQQ + HQK I + SQ + + +L L ++ + L +
Sbjct: 701 MELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEY 760
Query: 245 VDSPEKLKNYKEKM---KDTVQKLKNARQEVVEKYE---IYGDSVDCLPS----CQLEVQ 294
+ LK+ + +D + L Q+ + I G+ +PS C+LE
Sbjct: 761 ESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQ-GSMPSERSECRLEAD 819
Query: 295 LYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLK--TEENSFKRLMIVKKEKL 352
K L + + L L+ + ++ EL ++K EEN K + +
Sbjct: 820 QSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVA 879
Query: 353 ATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVY---ERVTTINQEIQKIKLGIQQLK 409
T+Q +I+K ED ++ V E + ++ K + ++V T EIQ++K L+
Sbjct: 880 ETSQ-RISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLE 938
Query: 410 DAAEREKLKSQEIFLNLK 427
D+ + +L S+ + L K
Sbjct: 939 DSLKELQLLSETLSLEKK 956
Score = 39.3 bits (90), Expect = 0.008
Identities = 52/273 (19%), Positives = 111/273 (40%), Gaps = 49/273 (17%)
Query: 205 LQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESL----------KTKIVDSPEKLKNY 254
L+ S K S I + R++ L+ S+ S K++ L K +I ++ K +
Sbjct: 816 LEADQSPKNSAILQN--RVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM 873
Query: 255 KEK-MKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLY-------QKKIQDLSDN 306
+ + +T Q++ +++ + +++ L + + E+QL Q +IQ+L +
Sbjct: 874 HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKS 933
Query: 307 REKLASILK------ESLNLE---------------DQIESDESELKKLKTEENSFKRLM 345
L LK E+L+LE +++ + LK++ N K +
Sbjct: 934 NHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNL 993
Query: 346 IVKKEKLAT----AQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKI 401
I K E A + I++ + KQ K +++ C + + ++ ++ K+
Sbjct: 994 IQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKL 1053
Query: 402 KLGIQQLKDAAEREKLKSQEIFLNLKTALEKYH 434
+ + + E K + ++ LK A K H
Sbjct: 1054 ECLLNECTSLCENRKNELEQ----LKEAFAKEH 1082
Score = 33.9 bits (76), Expect = 0.32
Identities = 34/169 (20%), Positives = 75/169 (44%), Gaps = 9/169 (5%)
Query: 216 ISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNAR-QEVVE 274
I E +L++LK + +SL+ + +K++N EK + T K +N R E+ E
Sbjct: 20 IQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVEN--EKTEGTNLKRENQRLMEICE 77
Query: 275 KYEIYGDSVDCLPSCQLEVQLYQKKIQD--LSDNREKLASILKESLNLEDQIESDESELK 332
E + S +L+V+ Q Q+ L+ ++++ + +E + ++E + +
Sbjct: 78 SLEKTKQKI----SHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQ 133
Query: 333 KLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQ 381
N + L +Q+ K+ED+K+ +E+ +++
Sbjct: 134 SADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLE 182
Score = 32.0 bits (71), Expect = 1.2
Identities = 40/181 (22%), Positives = 75/181 (41%), Gaps = 24/181 (13%)
Query: 206 QEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKL 265
Q N+ + ++ +LNEL+ L+ + L T++ DS + KM + V KL
Sbjct: 1283 QNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKL 1342
Query: 266 KNARQEVVEKYEI-YGDSVDCLPSCQLEVQ----------------------LYQKKIQ- 301
N + + + + +G+ V+ +P + Q L K++Q
Sbjct: 1343 LNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQM 1402
Query: 302 DLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINK 361
++ +EK S+ E L DQ S++ +L+T +S K +V L Q + K
Sbjct: 1403 HFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVK 1462
Query: 362 K 362
+
Sbjct: 1463 E 1463
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 64.7 bits (156), Expect = 2e-10
Identities = 75/347 (21%), Positives = 149/347 (42%), Gaps = 29/347 (8%)
Query: 134 CRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF-KQLSDG---IQE 189
C+ET Q + + L E L +LE++ + + E+ + QL D I++
Sbjct: 298 CKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQ 357
Query: 190 LQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPE 249
L+Q + + E K+ I++ R+ ++ L+E +E + + E
Sbjct: 358 LEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELE 417
Query: 250 KLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDL--SDNR 307
K + +K ++ +KLK E ++ E S + S Q E+ ++++ D+ +
Sbjct: 418 KALSTAQKTEEARRKLKAEMDEQIKTIE--KTSEEERISLQQELSRVKQEVVDVMKKSSE 475
Query: 308 EKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVK 367
E++A + K L+ ++ ++ KKL+T E F+ M V EK + KI+++ E +
Sbjct: 476 EQIAKLQK--LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQE 533
Query: 368 ---------QYKRTVIEDCNKVQE-------KRGAVYERVTTINQEIQKIKLGIQQLKDA 411
Q K + E NK+++ R + E +++ + +Q+ K + L
Sbjct: 534 SLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVH 593
Query: 412 AEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRK 458
E EK K + + +EK+ +E A EK LK++
Sbjct: 594 LEAEKNKHNK---EITVMVEKHKTELESLKHQQDALWTEKLQVLKQQ 637
Score = 64.7 bits (156), Expect = 2e-10
Identities = 75/341 (21%), Positives = 155/341 (45%), Gaps = 32/341 (9%)
Query: 144 QYKSSADKMQQLNAAHQEAL----MKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFH 199
Q K++ L ++ L + E+ + VE++ Q+ +G ++ + L Q
Sbjct: 873 QNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLS 932
Query: 200 QKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMK 259
K + N + ++ + K++ ++K KE+QE+LK K++D KLK E
Sbjct: 933 AKEDSIHILNEEYETKFKNQEKKMEKVKQKA---KEMQETLKKKLLDQEAKLKKELENTA 989
Query: 260 -DTVQKLKNARQEVVEKYEI----YGDSVDCLPSCQLE-----VQLYQKKIQDLSDNREK 309
+ QK K +++E + D+V L + Q E +++++++ D+ EK
Sbjct: 990 LELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEK 1049
Query: 310 LASILKESLN--LEDQIESDESELKKLK-------TEENSFKRLMIVKKEKLATAQFKIN 360
+ E L E Q++ E E+ +LK E+ + + KE+ +N
Sbjct: 1050 KLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLN 1109
Query: 361 KKHEDVKQYKRTVIEDCNKVQEKRGAVYERV-TTINQEIQK---IKLGIQQLKDAAEREK 416
+ E +KQ K + + + K A E++ +N+ +++ ++ + +LK AE +K
Sbjct: 1110 ELQEQLKQ-KSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK 1168
Query: 417 LKSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKR 457
K E+ LKT E++ ++ + E S +++K+ E K+
Sbjct: 1169 RKVSELTSKLKTTDEEF-QSLKSSHEKSNKSLEDKSLEFKK 1208
Score = 52.8 bits (125), Expect = 7e-07
Identities = 65/349 (18%), Positives = 159/349 (45%), Gaps = 33/349 (9%)
Query: 144 QYKSSADKMQQLNAAHQEALMK---------LERLDSVPVEE----QEEFKQLSDGIQEL 190
QY++ +K+++ +E L+K +E ++ +E+ Q E + LS + E+
Sbjct: 637 QYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEV 696
Query: 191 QQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNE--------LKLSVVSLKEIQESLKT 242
++ ++ + +++ + + K+ ++ ++ N +K VS++ +++LK
Sbjct: 697 LKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKD 756
Query: 243 KIVDSPEKLKNYKEKMKDTVQKLKNARQEVVE---KYEIYGDSVDCLPSCQLEVQLYQKK 299
+I LK + +K+ ++N ++ + + +D S Q K
Sbjct: 757 QINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKA 816
Query: 300 IQD-LSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFK 358
++ L+ ++KL + E + L Q+ E++ K + TE ++ K + ++L +
Sbjct: 817 YEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSE 876
Query: 359 INKKHEDVKQYKRTVIEDCNKVQEKRGAVY---ERVTTINQEIQKIKLGIQQLKDAAERE 415
+ +K + + Q + +ED NK QE+ + E + +E QK ++ I K +A+ +
Sbjct: 877 MEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKED 936
Query: 416 KL-----KSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKM 459
+ + + F N + +EK ++ E K+ ++ A+LK+++
Sbjct: 937 SIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKEL 985
Score = 52.8 bits (125), Expect = 7e-07
Identities = 90/476 (18%), Positives = 197/476 (41%), Gaps = 94/476 (19%)
Query: 62 EHFYMMPVNSEVMYPHLMEGFLPFSNLVTHLDSFLPIC-----RVNDFETADILCPKAKR 116
E F + + E L + L F L L L IC + + +T +++ + +
Sbjct: 1183 EEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSK 1242
Query: 117 TSRFLSGIINFIHFREACRE-------TYMEFLWQYKSSADKMQQLNAAHQEALMKLERL 169
T+ LS I + H +E T E Q + ++ LN + Q+A +LE
Sbjct: 1243 TNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLE-- 1300
Query: 170 DSVPVEEQEEFKQLSDGIQEL---QQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNEL 226
E++ + K + I+ L +++L ++ + Q+ S+K+S I++ K L+E
Sbjct: 1301 -----EKENQIKSMKADIESLVTEKEALQKEGGNQ----QQAASEKESCITQLKKELSEN 1351
Query: 227 KLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTV-------------QKLKNARQEVV 273
+V +KE + K +I ++L + ++++++ ++ + E++
Sbjct: 1352 INAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELL 1411
Query: 274 EKYEIYGDSVDCL----------------------PSCQLEVQLYQKKIQDL-------- 303
++ + VD L Q +Q +++L
Sbjct: 1412 DQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471
Query: 304 --SDNREKLASILKESLN--------LEDQIESDESELKK----LKTEENSFKRLMIVKK 349
+ +++ ++LKE L+ L+ ++E D+S+++K L+TE S ++ +
Sbjct: 1472 KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELE 1531
Query: 350 EKLATAQFKINKKHEDVKQYK-------RTVIEDCNKVQEKRGAVYERVTTINQEIQKIK 402
+ + +I +E +K Y + +++ QE RV ++I ++
Sbjct: 1532 DHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLE 1591
Query: 403 LGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRK 458
+ +K E +K + + + L++K+ E+ ++ +S AK+ AELKRK
Sbjct: 1592 NQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKL----AELKRK 1643
Score = 50.4 bits (119), Expect = 3e-06
Identities = 66/323 (20%), Positives = 137/323 (42%), Gaps = 54/323 (16%)
Query: 152 MQQLNAAHQEALMKLERLDSVPVEEQE----EFKQLSDGIQELQQSLNQDFHQKTIVLQE 207
+Q+ Q K++ LDS V ++E E ++L+ ++LQ D K L E
Sbjct: 1842 LQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLE 1901
Query: 208 GNSQKKSN--------ISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMK 259
N+++KS +S + N+L+ + + ++ L +IV + L+ +++ +
Sbjct: 1902 ENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ 1961
Query: 260 DTVQKLKNAR-QEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESL 318
++ LK QE EK + + ++ + L+ QL ++ L+ ++L +KE++
Sbjct: 1962 QELEILKKEYDQEREEKIKQEQEDLELKHNSTLK-QLMREFNTQLAQKEQELEMTIKETI 2020
Query: 319 NLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKR------- 371
N ++E++ E + +T + ++KK I +K +D+K+ +
Sbjct: 2021 NKAQEVEAELLESHQEETNQ-------LLKK---------IAEKDDDLKRTAKRYEEILD 2064
Query: 372 --------------TVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKL 417
T +E+ K +++ E N I +++ + Q KL
Sbjct: 2065 AREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKL 2124
Query: 418 KSQEI---FLNLKTALEKYHDGI 437
K QE NL+ L+KY +
Sbjct: 2125 KEQEFREQIHNLEDRLKKYEKNV 2147
Score = 49.7 bits (117), Expect = 6e-06
Identities = 74/328 (22%), Positives = 147/328 (44%), Gaps = 33/328 (10%)
Query: 154 QLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEG---NS 210
++ +QE L+KLE ++ E+Q L + ++E + + Q V +EG N
Sbjct: 1768 EMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQH--VEKEGGKNNI 1825
Query: 211 QKKSNI----SEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLK 266
Q K N+ + K L E +L+ L++ + L + +V E + E++ +KL+
Sbjct: 1826 QAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQ 1885
Query: 267 -----NARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLE 321
+ R + E E ++ + S ++ +L +D KLA +E L
Sbjct: 1886 ALQQMDGRNKPTELLE--ENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLG 1943
Query: 322 DQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQ 381
+I + +L+ L+ E + L I+KKE + KI ++ ED++ + ++ +
Sbjct: 1944 KEIVRLQKDLRMLRKEHQ--QELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMR-- 1999
Query: 382 EKRGAVYERVTTINQEIQKIKLGIQQLKDAA---EREKLKSQEIFLN--LKTALEKYHDG 436
E T + Q+ Q++++ I++ + A E E L+S + N LK EK D
Sbjct: 2000 -------EFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEK-DDD 2051
Query: 437 IEKAAEDSYAKIDEKTAELKRKMFKMST 464
+++ A+ +D + E+ K+ + T
Sbjct: 2052 LKRTAKRYEEILDAREEEMTAKVRDLQT 2079
Score = 47.0 bits (110), Expect = 4e-05
Identities = 44/214 (20%), Positives = 93/214 (43%), Gaps = 29/214 (13%)
Query: 153 QQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQK 212
QQ + H+E + KL+ + E+ K+ +K + L+
Sbjct: 1553 QQKDIEHKELVQKLQHFQELGEEKDNRVKEA---------------EEKILTLENQVYSM 1597
Query: 213 KSNISEKTKRLNELKLSVVSLKEIQESLKTKI-VDSPEKLKNYKEKMKDTVQKL-KNARQ 270
K+ + K K L + LSV S +E ++L+ ++ +S KL K K + + + K
Sbjct: 1598 KAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLS 1657
Query: 271 EVVEKYEIYGDSVDC--------LPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLED 322
++ EK E Y + L + EV + ++K++ + ++ + + + + N+
Sbjct: 1658 QMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAA 1717
Query: 323 QIESDESE----LKKLKTEENSFKRLMIVKKEKL 352
E +E++ ++K E+ S + + +KEKL
Sbjct: 1718 YTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKL 1751
Score = 45.8 bits (107), Expect = 8e-05
Identities = 60/292 (20%), Positives = 121/292 (41%), Gaps = 42/292 (14%)
Query: 160 QEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDF--HQKTIV-LQEGNSQKKSNI 216
Q+ K++ L + E+ S+ E ++ F HQ T+ LQ K
Sbjct: 1415 QDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEA 1474
Query: 217 SEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNAR------- 269
EK +++N LK + + + LK ++ D K++ KE +T K + AR
Sbjct: 1475 YEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEK-KESNLETELKSQTARIMELEDH 1533
Query: 270 --------QEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLE 321
+ + E + Y D ++ + +++ + DNR K A ++ L LE
Sbjct: 1534 ITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAE--EKILTLE 1591
Query: 322 DQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYK-RTVIEDCNKV 380
+Q+ S ++EL+ KK++L + K E++K + R E K+
Sbjct: 1592 NQVYSMKAELE--------------TKKKELEHVNLSVKSKEEELKALEDRLESESAAKL 1637
Query: 381 QEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEK 432
E + +++ I +++ + Q+++ E+ K ++ L T L++
Sbjct: 1638 AELKRKAEQKIAAIKKQL------LSQMEEKEEQYKKGTESHLSELNTKLQE 1683
Score = 43.5 bits (101), Expect = 4e-04
Identities = 70/375 (18%), Positives = 165/375 (44%), Gaps = 55/375 (14%)
Query: 133 ACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQ---- 188
A ++ E+L K S +K QQ + A +E ++ + + + + + +Q ++ +
Sbjct: 514 ALEKSQSEYL---KISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRIL 570
Query: 189 ----ELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKI 244
L++SL ++ +Q + ++K + E T + + K + SLK Q++L T+
Sbjct: 571 ELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEK 630
Query: 245 VD--------SPEKLKNYKEKMKDTVQK---------LKNARQEVVEKYEIYGDSVDCLP 287
+ EKL+ E+ K+T+ K ++ ++ +EK ++ ++ L
Sbjct: 631 LQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLS 690
Query: 288 SCQLEVQLYQKKIQD----LSDNREKLASILK--------------ESLNLEDQIESDES 329
S EV + K+++ L D +K+ L+ +S+ E ++ +
Sbjct: 691 SELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRT 750
Query: 330 ELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKV---QEKRGA 386
E K LK + N + L+ + + L Q + D+K+ + + + K+ Q + A
Sbjct: 751 E-KALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSA 809
Query: 387 VYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQ--EIFLNLKTALEKYHDGIEKAAEDS 444
+E+ +++ +++ + L+ ER L Q E+ K + D + +D
Sbjct: 810 THEQTKAYEEQLAQLQQKLLDLE--TERILLTKQVAEVEAQKKDVCTEL-DAHKIQVQDL 866
Query: 445 YAKIDEKTAELKRKM 459
+++++ +E+++K+
Sbjct: 867 MQQLEKQNSEMEQKV 881
Score = 42.0 bits (97), Expect = 0.001
Identities = 57/309 (18%), Positives = 128/309 (41%), Gaps = 33/309 (10%)
Query: 136 ETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLN 195
E E W + + LN ++ K ++S+ +E + L +L +SL
Sbjct: 1089 EMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLK 1148
Query: 196 QD--FHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKN 253
++ ++ + L+ + K +SE T +L SLK E + D + K
Sbjct: 1149 ENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKK 1208
Query: 254 YKEKM--------KDTVQKLKNARQEVVEKYEIYGDSV-DCLPSCQLEVQLYQK----KI 300
E++ K T L+ E++ +++ + CQ ++ K
Sbjct: 1209 LSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKT 1268
Query: 301 QDLSDNREKLASILKE--SLNLE-----DQIESDESELKKLKTEENSFKRLMIVKKEKL- 352
+S+ +L + +E +LN+ Q+E E+++K +K + S ++ +KE L
Sbjct: 1269 CTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIES----LVTEKEALQ 1324
Query: 353 ---ATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYER---VTTINQEIQKIKLGIQ 406
Q ++K + Q K+ + E+ N V + + E+ ++++++++ + + +Q
Sbjct: 1325 KEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQ 1384
Query: 407 QLKDAAERE 415
+E+E
Sbjct: 1385 NSISLSEKE 1393
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 64.3 bits (155), Expect = 2e-10
Identities = 87/362 (24%), Positives = 166/362 (45%), Gaps = 52/362 (14%)
Query: 146 KSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVL 205
+ +A K+ ++ +Q K+E L++ V+E++ + + ++L + Q +KTI
Sbjct: 487 EGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ--LEKTIET 544
Query: 206 QEGNSQKKSNISE-KTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQK 264
NS+++ I E + + LN+ S+ +I + K ++ K+ + E +K+T K
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH--ESIKETSSK 602
Query: 265 L------KNARQEVVEKYEIYGDSVDCLPS----CQLEVQLYQKKIQDLSDNREKLASI- 313
L K ++ +E Y+ G+ + L + + E +L QKKI +L EK+ ++
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 314 ------------LKESL----NLEDQIESDESELKKLKTEENSFKR-LMIVKKEKLATAQ 356
LK++L NL Q+ES E E +L E +R + +K + AQ
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ 722
Query: 357 FKI-NKKHEDVKQYKRTVIEDCN---KVQEKRGAVYERVTTINQEIQKI----KLGIQQL 408
++ NK+ E K+ + +E K E+ Y+ + NQ +QK IQQL
Sbjct: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 409 KDAAEREKLKSQEIFLNLK---------TALEKYHDGIEKAAEDSYAKIDEKTAELKRKM 459
+ + ++++Q + NL+ LEK + +E+ E S + D+K E + K
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ--ETSQLEKDKKQLEKENKR 840
Query: 460 FK 461
+
Sbjct: 841 LR 842
Score = 53.9 bits (128), Expect = 3e-07
Identities = 54/281 (19%), Positives = 138/281 (49%), Gaps = 28/281 (9%)
Query: 132 EACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQ 191
E+ +E + L K+S K ++L ++Q ++ +RL ++ +QL +Q+L+
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790
Query: 192 ---QSLNQDFHQKTI------VLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKT 242
Q+L ++ + I L++ N + S+ K +L+ L++ E T
Sbjct: 791 MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850
Query: 243 KIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLY------ 296
+ ++ K+ N +++ K +++ ++ V E+ ++ + + ++++
Sbjct: 851 TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED 910
Query: 297 ----QKKIQDLSDNREKLASIL-KESLN----LEDQIESDESELKKLKTE-ENSFKRLMI 346
+ K Q ++++ EKL L K LN L D+ +D+S K L+++ E++ K+ +
Sbjct: 911 LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLE 970
Query: 347 VKKEKLATAQFKINKK---HEDVKQYKRTVIEDCNKVQEKR 384
+K+EK+A + ++ + ++ ++Q +TV ++ +++++
Sbjct: 971 IKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1011
Score = 52.0 bits (123), Expect = 1e-06
Identities = 75/364 (20%), Positives = 149/364 (40%), Gaps = 74/364 (20%)
Query: 146 KSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQ----QSLNQDFHQK 201
++ +DK+ +L + + KL ++ ++++ ++L + L+ QS+++ H
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430
Query: 202 TIVLQEGNSQKKSNISEKT--KRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMK 259
+ Q + + S +K+ +NEL S + E++ TK V+ + E
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA 490
Query: 260 DTVQKLKNARQEVVEKYEIYGDSV----DCLPSCQ-------LEVQLYQKKIQDLSDNRE 308
+ K++ Q + +K EI + + L +CQ E +K I+ L +N E
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE 550
Query: 309 KLASIL------------------------------KESLNLEDQIESDESELKKLKTEE 338
+ IL KE+ L + I+ S+L K++ E+
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEK 610
Query: 339 NSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEI 398
K+ + KEK A+ N+ H +E N++ +K ++T +
Sbjct: 611 RQIKKELEHYKEKGERAEELENELHH---------LEKENELLQK------KITNLKITC 655
Query: 399 QKIKLGIQQLKDAAEREK---LKSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAEL 455
+KI+ ++Q ERE K+ + F NL LE + E +++DE+ EL
Sbjct: 656 EKIE-ALEQENSELERENRKLKKTLDSFKNLTFQLE--------SLEKENSQLDEENLEL 706
Query: 456 KRKM 459
+R +
Sbjct: 707 RRNV 710
Score = 41.2 bits (95), Expect = 0.002
Identities = 58/327 (17%), Positives = 139/327 (42%), Gaps = 30/327 (9%)
Query: 146 KSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQS---------LNQ 196
K+ +++ N Q ++ L+R +V ++EQ Q + +++ S +NQ
Sbjct: 1066 KTQLKQLETQNNNLQAQILALQR-QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ 1124
Query: 197 DFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKE 256
+ + ++ Q + ++ ++ + L L S++ E E L + E L +
Sbjct: 1125 N--AQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHG 1182
Query: 257 KMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKE 316
+K + L+ +++ ++Y L + +++ Q+K+ + N E +A+ K+
Sbjct: 1183 TLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKK 1242
Query: 317 SLNLEDQIESDESELKK----LKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRT 372
D++ S+L K L+T+ + K L+ K + + + +K E +Q T
Sbjct: 1243 LCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT 1302
Query: 373 ---VIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIF------ 423
+ C + + +G + E + +IQ + L + L + + ++S+++F
Sbjct: 1303 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE----QNMESKDLFHVEQRQ 1358
Query: 424 -LNLKTALEKYHDGIEKAAEDSYAKID 449
++ L + + +E+ D Y D
Sbjct: 1359 YIDKLNELRRQKEKLEEKIMDQYKFYD 1385
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 64.3 bits (155), Expect = 2e-10
Identities = 87/362 (24%), Positives = 166/362 (45%), Gaps = 52/362 (14%)
Query: 146 KSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVL 205
+ +A K+ ++ +Q K+E L++ V+E++ + + ++L + Q +KTI
Sbjct: 487 EGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ--LEKTIET 544
Query: 206 QEGNSQKKSNISE-KTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQK 264
NS+++ I E + + LN+ S+ +I + K ++ K+ + E +K+T K
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH--ESIKETSSK 602
Query: 265 L------KNARQEVVEKYEIYGDSVDCLPS----CQLEVQLYQKKIQDLSDNREKLASI- 313
L K ++ +E Y+ G+ + L + + E +L QKKI +L EK+ ++
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 314 ------------LKESL----NLEDQIESDESELKKLKTEENSFKR-LMIVKKEKLATAQ 356
LK++L NL Q+ES E E +L E +R + +K + AQ
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ 722
Query: 357 FKI-NKKHEDVKQYKRTVIEDCN---KVQEKRGAVYERVTTINQEIQKI----KLGIQQL 408
++ NK+ E K+ + +E K E+ Y+ + NQ +QK IQQL
Sbjct: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 409 KDAAEREKLKSQEIFLNLK---------TALEKYHDGIEKAAEDSYAKIDEKTAELKRKM 459
+ + ++++Q + NL+ LEK + +E+ E S + D+K E + K
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ--ETSQLEKDKKQLEKENKR 840
Query: 460 FK 461
+
Sbjct: 841 LR 842
Score = 52.0 bits (123), Expect = 1e-06
Identities = 75/364 (20%), Positives = 149/364 (40%), Gaps = 74/364 (20%)
Query: 146 KSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQ----QSLNQDFHQK 201
++ +DK+ +L + + KL ++ ++++ ++L + L+ QS+++ H
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430
Query: 202 TIVLQEGNSQKKSNISEKT--KRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMK 259
+ Q + + S +K+ +NEL S + E++ TK V+ + E
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA 490
Query: 260 DTVQKLKNARQEVVEKYEIYGDSV----DCLPSCQ-------LEVQLYQKKIQDLSDNRE 308
+ K++ Q + +K EI + + L +CQ E +K I+ L +N E
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE 550
Query: 309 KLASIL------------------------------KESLNLEDQIESDESELKKLKTEE 338
+ IL KE+ L + I+ S+L K++ E+
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEK 610
Query: 339 NSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEI 398
K+ + KEK A+ N+ H +E N++ +K ++T +
Sbjct: 611 RQIKKELEHYKEKGERAEELENELHH---------LEKENELLQK------KITNLKITC 655
Query: 399 QKIKLGIQQLKDAAEREK---LKSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAEL 455
+KI+ ++Q ERE K+ + F NL LE + E +++DE+ EL
Sbjct: 656 EKIE-ALEQENSELERENRKLKKTLDSFKNLTFQLE--------SLEKENSQLDEENLEL 706
Query: 456 KRKM 459
+R +
Sbjct: 707 RRNV 710
Score = 50.1 bits (118), Expect = 4e-06
Identities = 52/281 (18%), Positives = 134/281 (47%), Gaps = 29/281 (10%)
Query: 132 EACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQ 191
E+ +E + L K+S K ++L ++Q ++ +RL ++ +QL +Q+L+
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790
Query: 192 ---QSLNQDFHQKTI------VLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKT 242
Q+L ++ + I L++ N + S+ K +L+ L++ E T
Sbjct: 791 MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850
Query: 243 KIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLY------ 296
+ ++ K+ N +++ K +++ ++ V E+ ++ + + ++++
Sbjct: 851 TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED 910
Query: 297 ----QKKIQDLSDNREKLASIL------KESLNLEDQIESDESELKKLKTEENSFKRLMI 346
+ K Q ++++ EKL L KE L ++Q D +L + K E++ K+ +
Sbjct: 911 LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL-ESTLKKSLE 969
Query: 347 VKKEKLATAQFKINKK---HEDVKQYKRTVIEDCNKVQEKR 384
+K+EK+A + ++ + ++ ++Q +TV ++ +++++
Sbjct: 970 IKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1010
Score = 42.0 bits (97), Expect = 0.001
Identities = 51/311 (16%), Positives = 144/311 (46%), Gaps = 32/311 (10%)
Query: 151 KMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNS 210
K QQ+N ++ +LE++ + + D + L+ L + + +E +
Sbjct: 917 KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIA 976
Query: 211 QKKSNISEKTKRLNELKLSVVSLKEIQESLKTK------IVDSPE---KLKNYKEKMKDT 261
++ + E T +L+ + ++K+ E+LK + + SP + ++ + ++T
Sbjct: 977 ALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQET 1036
Query: 262 VQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLE 321
++L + ++E ++ L+ QL Q + Q+ ++ + ++ ++ +++++L+
Sbjct: 1037 TRELLKVKDRLIEVER--NNATLQAEKQALKTQLKQLETQN-NNLQAQILALQRQTVSLQ 1093
Query: 322 DQIESDESELKKLKTEENSF----------KRLMIVKKEKLATAQFKINKKHEDVKQYKR 371
+Q + +++ KL+ E ++ +++++ L + K+ ED+K
Sbjct: 1094 EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD 1153
Query: 372 TVIEDCNKVQ---EKRGAVYERVT----TINQEIQKIKLGIQQLKDAAE---REKLKSQE 421
++I+D K++ E++ + YE + T+ + +++ + L+D ++K + ++
Sbjct: 1154 SLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED 1213
Query: 422 IFLNLKTALEK 432
+ LK EK
Sbjct: 1214 LEKMLKVEQEK 1224
Score = 41.2 bits (95), Expect = 0.002
Identities = 58/327 (17%), Positives = 139/327 (42%), Gaps = 30/327 (9%)
Query: 146 KSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQS---------LNQ 196
K+ +++ N Q ++ L+R +V ++EQ Q + +++ S +NQ
Sbjct: 1065 KTQLKQLETQNNNLQAQILALQR-QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ 1123
Query: 197 DFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKE 256
+ + ++ Q + ++ ++ + L L S++ E E L + E L +
Sbjct: 1124 N--AQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHG 1181
Query: 257 KMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKE 316
+K + L+ +++ ++Y L + +++ Q+K+ + N E +A+ K+
Sbjct: 1182 TLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKK 1241
Query: 317 SLNLEDQIESDESELKK----LKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRT 372
D++ S+L K L+T+ + K L+ K + + + +K E +Q T
Sbjct: 1242 LCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT 1301
Query: 373 ---VIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIF------ 423
+ C + + +G + E + +IQ + L + L + + ++S+++F
Sbjct: 1302 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE----QNMESKDLFHVEQRQ 1357
Query: 424 -LNLKTALEKYHDGIEKAAEDSYAKID 449
++ L + + +E+ D Y D
Sbjct: 1358 YIDKLNELRRQKEKLEEKIMDQYKFYD 1384
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 64.3 bits (155), Expect = 2e-10
Identities = 61/300 (20%), Positives = 133/300 (44%), Gaps = 43/300 (14%)
Query: 179 EFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQE 238
E K L + I++L++ + + H + L+E N+ ++ + + +++ + + +L++ +E
Sbjct: 488 EIKNLKEEIEKLRKQVTESSHLEQ-QLEEANAVRQE-LDDAFRQIKAYEKQIKTLQQERE 545
Query: 239 SLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQK 298
L ++V + E+LKN +++KD + K A QE +E +
Sbjct: 546 DLNKELVQASERLKNQSKELKDAHCQRKLAMQEFME---------------------INE 584
Query: 299 KIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFK 358
++ +L ++KLA +++ D + L++ K+ + V E LA K
Sbjct: 585 RLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASK 644
Query: 359 INKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTI--NQEIQKIKLGIQQLKDAAEREK 416
K E + Y + + + +++K+ + V +I QEI K+K +++ E E
Sbjct: 645 DRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEEL 704
Query: 417 LKSQEIFLN-LKTALEKYHDG-----------------IEKAAEDSYAKIDEKTAELKRK 458
K + I N +K ++ HD +EK +S ++ +E +E K++
Sbjct: 705 SKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQ 764
Score = 30.8 bits (68), Expect = 2.7
Identities = 17/53 (32%), Positives = 29/53 (54%)
Query: 189 ELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLK 241
ELQ +L+ + K + +E N K SNI + K + K ++ L EI++ +K
Sbjct: 881 ELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIK 933
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 63.5 bits (153), Expect = 4e-10
Identities = 57/301 (18%), Positives = 151/301 (50%), Gaps = 22/301 (7%)
Query: 171 SVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSV 230
SV EE ++ KQ +D +++ +L +D KT+++++ + +++ +S KT LN+ +L
Sbjct: 1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERA-LSRKTDELNK-QLKD 1061
Query: 231 VSLKEIQ-ESLKTKIVDSPEK-------LKNYKEKMKDTVQKLKNARQEVVEKYEIYGDS 282
+S K + +++K K+V+ K ++N +K +++++ ++ + E +
Sbjct: 1062 LSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEE 1121
Query: 283 VDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELK-KLKTEENSF 341
+ + C + Q K+ L +N++ + L E L +++ E + +K L+ +E
Sbjct: 1122 LKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEES 1181
Query: 342 KRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKI 401
+ K E+++ Q ++ + +K+ + + D +K + + + +++++N+++ +
Sbjct: 1182 QN----KMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANL 1237
Query: 402 KLGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEK---TAELKRK 458
+++ + E L +++ ++ K E H IE+ +D + D+ EL+R+
Sbjct: 1238 NRKYEEVCE----EVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRR 1293
Query: 459 M 459
+
Sbjct: 1294 I 1294
Score = 60.8 bits (146), Expect = 2e-09
Identities = 74/340 (21%), Positives = 154/340 (45%), Gaps = 49/340 (14%)
Query: 154 QLNAAHQEALMKLERLDSVPVEEQ--EEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQ 211
Q AH+ A K L+ V+E E+ KQL D ++++Q+ + + K +Q
Sbjct: 451 QNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYES-EGKVKQMQTHFLA 509
Query: 212 KKSNISEKTKRLN-----ELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLK 266
K +++ + N ELK + LK E ++ KL+N ++ + V++ K
Sbjct: 510 LKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEV----GKLRNQIKQNEMIVEEFK 565
Query: 267 NARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESL------NL 320
+++E+ + L C++E + +K+ ++ ++L++ L S+ N+
Sbjct: 566 RDEGKLIEENKRLQKE---LSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENM 622
Query: 321 EDQIESDESELKKLKTE-----ENSFKRLMIVKKE----KLATAQFKINKKHEDVKQYKR 371
+ + ++ +E K E E S + +K+E K AQ ++HE VK
Sbjct: 623 KSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVK---- 678
Query: 372 TVIEDCNKVQEKRGAVYERVT-------TINQEIQKIKLGIQQLKDAAEREKLKSQEIFL 424
+++++K G + +++T T+ +EI+K+ L + LK+ A ++ + ++
Sbjct: 679 ------SRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYV 732
Query: 425 NLKTA--LEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKM 462
LK + ++K HD I + +K E K +M K+
Sbjct: 733 PLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKL 772
Score = 52.0 bits (123), Expect = 1e-06
Identities = 76/343 (22%), Positives = 153/343 (44%), Gaps = 45/343 (13%)
Query: 146 KSSADKMQQLNAAHQEA--LMKLERLDSVPVEEQEEFKQ-LSDGIQELQQSLN------Q 196
K + ++++A E L K+ VPV+ EE K L+D + + + L +
Sbjct: 819 KKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFE 878
Query: 197 DFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKT------KIVDS-PE 249
D +Q+ + +++ N K N+ E T+ N++K +SL E + + + K+ DS E
Sbjct: 879 DINQEFVKIKDKNEILKRNL-ENTQ--NQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAE 935
Query: 250 KLKNYKEKMKDTVQ---KLKNARQE---VVEKYEIYGDSVDCLPSCQLEVQLYQKKIQD- 302
L NY++ ++ V ++K ++E + E ++ + C+ + + +K+++D
Sbjct: 936 ILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQ 995
Query: 303 LSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKK 362
LS+ +K + E E+KK K E + K+ + ++ L I K
Sbjct: 996 LSEQTQKYSV--------------SEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKS 1041
Query: 363 HEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEI 422
HE + R ++ NK + Y V + +++ + + Q + A + L+ Q +
Sbjct: 1042 HEMERALSRKT-DELNKQLKDLSQKYTEVKNVKEKLVE-ENAKQTSEILAVQNLLQKQHV 1099
Query: 423 FLNLKTALEKYHDG-IEKAAED--SYAKIDEKTAELKRKMFKM 462
L AL+K +G IE E+ S + EK + K+ ++
Sbjct: 1100 PLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQL 1142
Score = 44.3 bits (103), Expect = 2e-04
Identities = 70/292 (23%), Positives = 129/292 (44%), Gaps = 54/292 (18%)
Query: 199 HQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKM 258
H+K I+ KSNI E K+L+E LK K + EK+ +
Sbjct: 796 HEKEIIAL------KSNIVELKKQLSE--------------LKKKCGEDQEKIHALTSEN 835
Query: 259 KDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLA---SILK 315
+ + + N V E+ D L E+ +KK +D++ K+ ILK
Sbjct: 836 TNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILK 895
Query: 316 ESL-NLEDQIESDESEL----KKLKTEENSFKRLMIVKKEKLAT---AQFKINKKHEDVK 367
+L N ++QI+++ L K+ + S +++ E LA Q +I H ++K
Sbjct: 896 RNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIK 955
Query: 368 QYKRTV--IEDCNKV------------QEKRGAVYERVTTINQEIQKIKLGIQQL-KDAA 412
K+ + I++C KV ++ + E ++++ QK + +++ K+
Sbjct: 956 AQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQ 1015
Query: 413 EREKLKSQEIF-----LNLKTAL-EKYHDGIEKAAEDSYAKIDEKTAELKRK 458
E +KLK +EIF L KT L EK H+ +E+A +++++ +L +K
Sbjct: 1016 ENDKLK-KEIFTLQKDLRDKTVLIEKSHE-MERALSRKTDELNKQLKDLSQK 1065
Score = 37.4 bits (85), Expect = 0.029
Identities = 56/284 (19%), Positives = 121/284 (42%), Gaps = 40/284 (14%)
Query: 189 ELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRL---NELKLSVVSLKEIQESLKTKIV 245
EL + + I+ +E + + S K RL NEL V K + +
Sbjct: 414 ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKE 473
Query: 246 DSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSD 305
DS E++K ++ +KD +++ + +V + + + L + + +
Sbjct: 474 DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHF-------------LALKEHLTSEAAS 520
Query: 306 NREKLASILKESL-NLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKIN--KK 362
+L LK+ L +L+ + E +E+ KL+ + +K+ ++ +FK + K
Sbjct: 521 GNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQ---------IKQNEMIVEEFKRDEGKL 571
Query: 363 HEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLK---S 419
E+ K+ ++ + C +EK+G +VT + + +++ + A + E +K S
Sbjct: 572 IEENKRLQKE-LSMCEMEREKKG---RKVTEMEGQAKELSAKLALSIPAEKFENMKSSLS 627
Query: 420 QEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMS 463
E+ K +E +E+ E S ++I + EL+ K++
Sbjct: 628 NEVNEKAKKLVE-----MEREHEKSLSEIRQLKRELENVKAKLA 666
Score = 37.4 bits (85), Expect = 0.029
Identities = 54/280 (19%), Positives = 120/280 (42%), Gaps = 35/280 (12%)
Query: 144 QYKSSADKMQQLNAAHQEALMKLERL---DSVPVEEQEEFKQLSDG-IQELQQSLNQDFH 199
+ K+ +K+ + NA ++ ++ L VP+E+ E K+ +G I+ L++ L
Sbjct: 1068 EVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKS--- 1124
Query: 200 QKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKE---IQESLKTKIVDSPEKLKNYKE 256
+Q +++ +++ + L K S V L E I+E+ + ++ L+ +E
Sbjct: 1125 -----MQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEE 1179
Query: 257 KMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKE 316
+ ++ ++++ + EV + Q +L +++ DLS + +
Sbjct: 1180 ESQNKMEEVSKLQSEVQN-------------TKQALKKLETREVVDLSKYKATKS----- 1221
Query: 317 SLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIED 376
+LE QI S +L L + ++ K+K +A+ + H ++Q + E
Sbjct: 1222 --DLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKER 1279
Query: 377 CNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREK 416
C+K + R+ ++I+ I +L + ER K
Sbjct: 1280 CDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLK 1319
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 63.5 bits (153), Expect = 4e-10
Identities = 57/301 (18%), Positives = 151/301 (50%), Gaps = 22/301 (7%)
Query: 171 SVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSV 230
SV EE ++ KQ +D +++ +L +D KT+++++ + +++ +S KT LN+ +L
Sbjct: 1017 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERA-LSRKTDELNK-QLKD 1074
Query: 231 VSLKEIQ-ESLKTKIVDSPEK-------LKNYKEKMKDTVQKLKNARQEVVEKYEIYGDS 282
+S K + +++K K+V+ K ++N +K +++++ ++ + E +
Sbjct: 1075 LSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEE 1134
Query: 283 VDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELK-KLKTEENSF 341
+ + C + Q K+ L +N++ + L E L +++ E + +K L+ +E
Sbjct: 1135 LKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEES 1194
Query: 342 KRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKI 401
+ K E+++ Q ++ + +K+ + + D +K + + + +++++N+++ +
Sbjct: 1195 QN----KMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANL 1250
Query: 402 KLGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEK---TAELKRK 458
+++ + E L +++ ++ K E H IE+ +D + D+ EL+R+
Sbjct: 1251 NRKYEEVCE----EVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRR 1306
Query: 459 M 459
+
Sbjct: 1307 I 1307
Score = 60.8 bits (146), Expect = 2e-09
Identities = 74/340 (21%), Positives = 154/340 (45%), Gaps = 49/340 (14%)
Query: 154 QLNAAHQEALMKLERLDSVPVEEQ--EEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQ 211
Q AH+ A K L+ V+E E+ KQL D ++++Q+ + + K +Q
Sbjct: 464 QNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYES-EGKVKQMQTHFLA 522
Query: 212 KKSNISEKTKRLN-----ELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLK 266
K +++ + N ELK + LK E ++ KL+N ++ + V++ K
Sbjct: 523 LKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEV----GKLRNQIKQNEMIVEEFK 578
Query: 267 NARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESL------NL 320
+++E+ + L C++E + +K+ ++ ++L++ L S+ N+
Sbjct: 579 RDEGKLIEENKRLQKE---LSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENM 635
Query: 321 EDQIESDESELKKLKTE-----ENSFKRLMIVKKE----KLATAQFKINKKHEDVKQYKR 371
+ + ++ +E K E E S + +K+E K AQ ++HE VK
Sbjct: 636 KSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVK---- 691
Query: 372 TVIEDCNKVQEKRGAVYERVT-------TINQEIQKIKLGIQQLKDAAEREKLKSQEIFL 424
+++++K G + +++T T+ +EI+K+ L + LK+ A ++ + ++
Sbjct: 692 ------SRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYV 745
Query: 425 NLKTA--LEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKM 462
LK + ++K HD I + +K E K +M K+
Sbjct: 746 PLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKL 785
Score = 52.0 bits (123), Expect = 1e-06
Identities = 76/343 (22%), Positives = 153/343 (44%), Gaps = 45/343 (13%)
Query: 146 KSSADKMQQLNAAHQEA--LMKLERLDSVPVEEQEEFKQ-LSDGIQELQQSLN------Q 196
K + ++++A E L K+ VPV+ EE K L+D + + + L +
Sbjct: 832 KKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFE 891
Query: 197 DFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKT------KIVDS-PE 249
D +Q+ + +++ N K N+ E T+ N++K +SL E + + + K+ DS E
Sbjct: 892 DINQEFVKIKDKNEILKRNL-ENTQ--NQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAE 948
Query: 250 KLKNYKEKMKDTVQ---KLKNARQE---VVEKYEIYGDSVDCLPSCQLEVQLYQKKIQD- 302
L NY++ ++ V ++K ++E + E ++ + C+ + + +K+++D
Sbjct: 949 ILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQ 1008
Query: 303 LSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKK 362
LS+ +K + E E+KK K E + K+ + ++ L I K
Sbjct: 1009 LSEQTQKYSV--------------SEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKS 1054
Query: 363 HEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEI 422
HE + R ++ NK + Y V + +++ + + Q + A + L+ Q +
Sbjct: 1055 HEMERALSRKT-DELNKQLKDLSQKYTEVKNVKEKLVE-ENAKQTSEILAVQNLLQKQHV 1112
Query: 423 FLNLKTALEKYHDG-IEKAAED--SYAKIDEKTAELKRKMFKM 462
L AL+K +G IE E+ S + EK + K+ ++
Sbjct: 1113 PLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQL 1155
Score = 44.3 bits (103), Expect = 2e-04
Identities = 70/292 (23%), Positives = 129/292 (44%), Gaps = 54/292 (18%)
Query: 199 HQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKM 258
H+K I+ KSNI E K+L+E LK K + EK+ +
Sbjct: 809 HEKEIIAL------KSNIVELKKQLSE--------------LKKKCGEDQEKIHALTSEN 848
Query: 259 KDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLA---SILK 315
+ + + N V E+ D L E+ +KK +D++ K+ ILK
Sbjct: 849 TNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILK 908
Query: 316 ESL-NLEDQIESDESEL----KKLKTEENSFKRLMIVKKEKLAT---AQFKINKKHEDVK 367
+L N ++QI+++ L K+ + S +++ E LA Q +I H ++K
Sbjct: 909 RNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIK 968
Query: 368 QYKRTV--IEDCNKV------------QEKRGAVYERVTTINQEIQKIKLGIQQL-KDAA 412
K+ + I++C KV ++ + E ++++ QK + +++ K+
Sbjct: 969 AQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQ 1028
Query: 413 EREKLKSQEIF-----LNLKTAL-EKYHDGIEKAAEDSYAKIDEKTAELKRK 458
E +KLK +EIF L KT L EK H+ +E+A +++++ +L +K
Sbjct: 1029 ENDKLK-KEIFTLQKDLRDKTVLIEKSHE-MERALSRKTDELNKQLKDLSQK 1078
Score = 37.4 bits (85), Expect = 0.029
Identities = 56/284 (19%), Positives = 121/284 (42%), Gaps = 40/284 (14%)
Query: 189 ELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRL---NELKLSVVSLKEIQESLKTKIV 245
EL + + I+ +E + + S K RL NEL V K + +
Sbjct: 427 ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKE 486
Query: 246 DSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSD 305
DS E++K ++ +KD +++ + +V + + + L + + +
Sbjct: 487 DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHF-------------LALKEHLTSEAAS 533
Query: 306 NREKLASILKESL-NLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKIN--KK 362
+L LK+ L +L+ + E +E+ KL+ + +K+ ++ +FK + K
Sbjct: 534 GNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQ---------IKQNEMIVEEFKRDEGKL 584
Query: 363 HEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLK---S 419
E+ K+ ++ + C +EK+G +VT + + +++ + A + E +K S
Sbjct: 585 IEENKRLQKE-LSMCEMEREKKG---RKVTEMEGQAKELSAKLALSIPAEKFENMKSSLS 640
Query: 420 QEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMS 463
E+ K +E +E+ E S ++I + EL+ K++
Sbjct: 641 NEVNEKAKKLVE-----MEREHEKSLSEIRQLKRELENVKAKLA 679
Score = 37.4 bits (85), Expect = 0.029
Identities = 54/280 (19%), Positives = 120/280 (42%), Gaps = 35/280 (12%)
Query: 144 QYKSSADKMQQLNAAHQEALMKLERL---DSVPVEEQEEFKQLSDG-IQELQQSLNQDFH 199
+ K+ +K+ + NA ++ ++ L VP+E+ E K+ +G I+ L++ L
Sbjct: 1081 EVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKS--- 1137
Query: 200 QKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKE---IQESLKTKIVDSPEKLKNYKE 256
+Q +++ +++ + L K S V L E I+E+ + ++ L+ +E
Sbjct: 1138 -----MQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEE 1192
Query: 257 KMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKE 316
+ ++ ++++ + EV + Q +L +++ DLS + +
Sbjct: 1193 ESQNKMEEVSKLQSEVQN-------------TKQALKKLETREVVDLSKYKATKS----- 1234
Query: 317 SLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIED 376
+LE QI S +L L + ++ K+K +A+ + H ++Q + E
Sbjct: 1235 --DLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKER 1292
Query: 377 CNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREK 416
C+K + R+ ++I+ I +L + ER K
Sbjct: 1293 CDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLK 1332
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 62.8 bits (151), Expect = 6e-10
Identities = 50/260 (19%), Positives = 125/260 (48%), Gaps = 10/260 (3%)
Query: 167 ERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNEL 226
+ L SV + Q + ++ EL LNQ +K +E +++ + E+ ++ E
Sbjct: 269 KELQSVSAKLQAQVEE-----NELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQ 323
Query: 227 KLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCL 286
+ + +E + KI + +K+ +EK+++ +K++ +++ + E + + +
Sbjct: 324 EEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKI 383
Query: 287 PSCQLEVQLYQKKIQDLSDNR-EKLASILKESLNLEDQIESDESELKKLKTEENSFKRLM 345
+ E+ ++KI++ + R EK+ K+ +++I E E+ + + + + +M
Sbjct: 384 QEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMM 443
Query: 346 IVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQE----IQKI 401
++EKL + K+ ++ E +++ + + K+QE+ + + + QE Q+
Sbjct: 444 QDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEE 503
Query: 402 KLGIQQLKDAAEREKLKSQE 421
K+ Q+ K + EK++ QE
Sbjct: 504 KMWRQEEKMWEQEEKMQEQE 523
Score = 50.1 bits (118), Expect = 4e-06
Identities = 59/286 (20%), Positives = 131/286 (45%), Gaps = 39/286 (13%)
Query: 146 KSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVL 205
+ DKM + +E K+ + ++E+ ++ + IQE ++ + + ++ I
Sbjct: 342 REQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQ--EEKIRE 399
Query: 206 QEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKL 265
QE Q+K EK R + K+ +E +E + + EK++ +E M+D +KL
Sbjct: 400 QEEKRQEKMWRQEKKMREQDEKI-----REQEEEMWRQ----EEKIRELEEMMQDQEEKL 450
Query: 266 KNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIE 325
+ +++ E+ E + + ++Q ++KIQ+ + + +LK+ + +Q E
Sbjct: 451 REVEEKMQEEEEKMQEQEE-------KIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEE 503
Query: 326 SDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRG 385
K + EE +++ +EK+ + K+ ++ E +++ + + + K+QE+
Sbjct: 504 ------KMWRQEEKMWEQ-----EEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEV 552
Query: 386 AVYERVTTINQEIQKIKL--------GIQQLKDAAE--REKLKSQE 421
+ E + + QK +L G Q+L + +LKSQE
Sbjct: 553 RLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQE 598
Score = 45.4 bits (106), Expect = 1e-04
Identities = 46/266 (17%), Positives = 126/266 (47%), Gaps = 25/266 (9%)
Query: 153 QQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQK 212
Q+L QE K+ R + E++E+ ++ D + ++ + + +K +E ++
Sbjct: 316 QELKIREQEE--KMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQ-EEKIREQEEKMWRQ 372
Query: 213 KSNISEKTKRLNELKLSV----VSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268
+ I E+ +++ E + + ++E +E + K+ +K++ EK+++ +++
Sbjct: 373 EEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQ 432
Query: 269 RQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDE 328
+++ E E+ D + L + ++Q ++K+Q+ + I ++ +++Q E
Sbjct: 433 EEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEK------IQRQEEKIQEQEEKTW 486
Query: 329 SELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVY 388
+ K LK ++EK+ + K+ ++ E + + + + E K+Q + +
Sbjct: 487 RQEKLLK------------QEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMR 534
Query: 389 ERVTTINQEIQKIKLGIQQLKDAAER 414
E+ + Q+ +K++ +L++ ER
Sbjct: 535 EQEVRLWQQEEKMQEQEVRLQELEER 560
Score = 40.4 bits (93), Expect = 0.003
Identities = 39/218 (17%), Positives = 99/218 (45%), Gaps = 20/218 (9%)
Query: 136 ETYMEFLWQYKSSADKMQQLNAAHQEALM----KLERLDSVPVEEQEEFKQLSDGIQELQ 191
E E +W+ + + + +E + K+ L+ + +++E+ +++ + +QE +
Sbjct: 402 EKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEE 461
Query: 192 QSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKL 251
+ + + ++ I QE Q++ EKT R +L + E +E K+ EK+
Sbjct: 462 EKMQEQ--EEKIQRQEEKIQEQE---EKTWRQEKLLKQEEKIWEQEE----KMWRQEEKM 512
Query: 252 KNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLA 311
+EKM++ +K++ +++ E+ + + ++ +Q ++++ L E L
Sbjct: 513 WEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLG 572
Query: 312 SILKES-------LNLEDQIESDESELKKLKTEENSFK 342
+ES L Q+E E + L+ +++ ++
Sbjct: 573 GAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYR 610
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 62.8 bits (151), Expect = 6e-10
Identities = 50/260 (19%), Positives = 125/260 (48%), Gaps = 10/260 (3%)
Query: 167 ERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNEL 226
+ L SV + Q + ++ EL LNQ +K +E +++ + E+ ++ E
Sbjct: 269 KELQSVSAKLQAQVEE-----NELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQ 323
Query: 227 KLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCL 286
+ + +E + KI + +K+ +EK+++ +K++ +++ + E + + +
Sbjct: 324 EEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKI 383
Query: 287 PSCQLEVQLYQKKIQDLSDNR-EKLASILKESLNLEDQIESDESELKKLKTEENSFKRLM 345
+ E+ ++KI++ + R EK+ K+ +++I E E+ + + + + +M
Sbjct: 384 QEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMM 443
Query: 346 IVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQE----IQKI 401
++EKL + K+ ++ E +++ + + K+QE+ + + + QE Q+
Sbjct: 444 QDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEE 503
Query: 402 KLGIQQLKDAAEREKLKSQE 421
K+ Q+ K + EK++ QE
Sbjct: 504 KMWRQEEKMWEQEEKMQEQE 523
Score = 50.1 bits (118), Expect = 4e-06
Identities = 59/286 (20%), Positives = 131/286 (45%), Gaps = 39/286 (13%)
Query: 146 KSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVL 205
+ DKM + +E K+ + ++E+ ++ + IQE ++ + + ++ I
Sbjct: 342 REQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQ--EEKIRE 399
Query: 206 QEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKL 265
QE Q+K EK R + K+ +E +E + + EK++ +E M+D +KL
Sbjct: 400 QEEKRQEKMWRQEKKMREQDEKI-----REQEEEMWRQ----EEKIRELEEMMQDQEEKL 450
Query: 266 KNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIE 325
+ +++ E+ E + + ++Q ++KIQ+ + + +LK+ + +Q E
Sbjct: 451 REVEEKMQEEEEKMQEQEE-------KIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEE 503
Query: 326 SDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRG 385
K + EE +++ +EK+ + K+ ++ E +++ + + + K+QE+
Sbjct: 504 ------KMWRQEEKMWEQ-----EEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEV 552
Query: 386 AVYERVTTINQEIQKIKL--------GIQQLKDAAE--REKLKSQE 421
+ E + + QK +L G Q+L + +LKSQE
Sbjct: 553 RLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQE 598
Score = 45.4 bits (106), Expect = 1e-04
Identities = 46/266 (17%), Positives = 126/266 (47%), Gaps = 25/266 (9%)
Query: 153 QQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQK 212
Q+L QE K+ R + E++E+ ++ D + ++ + + +K +E ++
Sbjct: 316 QELKIREQEE--KMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQ-EEKIREQEEKMWRQ 372
Query: 213 KSNISEKTKRLNELKLSV----VSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268
+ I E+ +++ E + + ++E +E + K+ +K++ EK+++ +++
Sbjct: 373 EEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQ 432
Query: 269 RQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDE 328
+++ E E+ D + L + ++Q ++K+Q+ + I ++ +++Q E
Sbjct: 433 EEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEK------IQRQEEKIQEQEEKTW 486
Query: 329 SELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVY 388
+ K LK ++EK+ + K+ ++ E + + + + E K+Q + +
Sbjct: 487 RQEKLLK------------QEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMR 534
Query: 389 ERVTTINQEIQKIKLGIQQLKDAAER 414
E+ + Q+ +K++ +L++ ER
Sbjct: 535 EQEVRLWQQEEKMQEQEVRLQELEER 560
Score = 40.4 bits (93), Expect = 0.003
Identities = 39/218 (17%), Positives = 99/218 (45%), Gaps = 20/218 (9%)
Query: 136 ETYMEFLWQYKSSADKMQQLNAAHQEALM----KLERLDSVPVEEQEEFKQLSDGIQELQ 191
E E +W+ + + + +E + K+ L+ + +++E+ +++ + +QE +
Sbjct: 402 EKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEE 461
Query: 192 QSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKL 251
+ + + ++ I QE Q++ EKT R +L + E +E K+ EK+
Sbjct: 462 EKMQEQ--EEKIQRQEEKIQEQE---EKTWRQEKLLKQEEKIWEQEE----KMWRQEEKM 512
Query: 252 KNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLA 311
+EKM++ +K++ +++ E+ + + ++ +Q ++++ L E L
Sbjct: 513 WEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLG 572
Query: 312 SILKES-------LNLEDQIESDESELKKLKTEENSFK 342
+ES L Q+E E + L+ +++ ++
Sbjct: 573 GAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYR 610
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 62.4 bits (150), Expect = 8e-10
Identities = 64/310 (20%), Positives = 148/310 (47%), Gaps = 36/310 (11%)
Query: 145 YKSSADKMQQLNAAHQEALMKLERL---------DSVPVEEQEEF--KQLSDGIQELQQS 193
+K A +M+Q N +EA + E + +S+ + +++E K+L D +EL+++
Sbjct: 287 HKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKN 346
Query: 194 LNQ--DFHQKTIVLQEGNSQKKSNISEKTKRLNELKLS----VVSLKEIQESLKTKIVDS 247
N+ Q+ L + K+ + + +++LK V+ +K Q LK ++
Sbjct: 347 TNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEM--- 403
Query: 248 PEKLKNYKEKMKDTVQKLKNARQEV-------VEKYEIYGDSVDCLPSCQLEVQL----- 295
+ K K+K+K+T KL A++E + + Y +S + + S +L+ +L
Sbjct: 404 -DSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEE-IKSNELDAKLRVTKG 461
Query: 296 -YQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLAT 354
+K++Q+ SD E + +KE +L+ + EL+ L+T+ + + +++L+
Sbjct: 462 ELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSK 521
Query: 355 AQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAER 414
+ IN++ ++ Q ++ +++QE+ + + + +E++ + I L+ E
Sbjct: 522 YKEIINRQKAEI-QNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEG 580
Query: 415 EKLKSQEIFL 424
+ + E+ L
Sbjct: 581 SRKRESELLL 590
Score = 50.8 bits (120), Expect = 3e-06
Identities = 66/316 (20%), Positives = 138/316 (43%), Gaps = 43/316 (13%)
Query: 160 QEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEK 219
Q+ ++ E + ++E ++ ++L I + +L ++ ++T E Q + I +
Sbjct: 199 QDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRT----ETEKQHMNTIKQL 254
Query: 220 TKRLNELKLSVVSLKEIQESLKTKIVDSPEKL-KNYKEKMKDTVQKLKNARQE---VVEK 275
R+ EL V + ++ + ++ ++L K ++M+ +K + ARQE +V K
Sbjct: 255 ESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMK 314
Query: 276 YEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLK 335
Y + G+ K+ DL +E L L+++ ++E + +++K+L
Sbjct: 315 Y-VRGE----------------KESLDLRKEKETLEKKLRDA---NKELEKNTNKIKQLS 354
Query: 336 TEENSFKRLMIVKKEKLATAQFKINKKHEDVKQY----------KRTVIEDCNKVQEKRG 385
E+ +L K+ + +I+K ED+ + + ++ + ++K
Sbjct: 355 QEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLK 414
Query: 386 AVYERVTTINQEIQKIKLGIQ-QLKDAAEREKLKSQEIFLNL---KTALEKYHDGIEKAA 441
++T +E +I+ Q +K E E++KS E+ L K LEK
Sbjct: 415 ETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQL 474
Query: 442 EDSYAKIDEKTAELKR 457
E +AKI E +LKR
Sbjct: 475 EMHHAKIKE-LEDLKR 489
Score = 41.2 bits (95), Expect = 0.002
Identities = 65/327 (19%), Positives = 142/327 (43%), Gaps = 53/327 (16%)
Query: 146 KSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVL 205
K + +K++ +H+E KL+ + + +EE Q+ Q++ ++ + K+ L
Sbjct: 393 KWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNEL 452
Query: 206 Q----------EGNSQKKSNISE----KTKRLNELKLSVVSLKEIQESLKTKI------- 244
E Q+KS+ E K K L +LK + + +L+TK+
Sbjct: 453 DAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDER 512
Query: 245 VDSPEKLKNYKE----------------KMKDTVQK-LKNARQEVVEKYEIYGDSVDCLP 287
+ + ++L YKE K D +Q+ L+ +QE+ E +
Sbjct: 513 LRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLIN 572
Query: 288 SCQLEVQLYQKKIQDLSDNREKLAS----ILKESLNLE---DQIESDESELKKL-----K 335
Q +++ +K+ +L E+L S + ES +L+ D++ ES+L+ +
Sbjct: 573 DLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQ 632
Query: 336 TEENSFKRLMI---VKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVT 392
T N RL+ ++KE++ T Q ++ + +VK V E +++ +R +
Sbjct: 633 TNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIK 692
Query: 393 TINQEIQKIKLGIQQLKDAAEREKLKS 419
+ +++Q+ + + Q++ + +++ S
Sbjct: 693 DLTKQLQQARRKLDQVESGSYDKEVSS 719
Score = 40.8 bits (94), Expect = 0.003
Identities = 51/203 (25%), Positives = 99/203 (48%), Gaps = 19/203 (9%)
Query: 142 LWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFH-- 199
L +YK ++ + A Q L K++ D + E+ + KQ + ++E +SLN +
Sbjct: 519 LSKYKEIINRQK---AEIQNLLDKVKTADQLQ-EQLQRGKQEIENLKEEVESLNSLINDL 574
Query: 200 QKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMK 259
QK I EG+ +++S + T+RL + S +S K+ S +L++ E+MK
Sbjct: 575 QKDI---EGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMK 631
Query: 260 DTVQKLKN--ARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSD----NREKLASI 313
T L++ ++E + K E+ + L Q EV+ ++++L D R K AS
Sbjct: 632 QTNINLESRLLKEEELRKEEVQTLQAE-LACRQTEVKALSTQVEELKDELVTQRRKHASS 690
Query: 314 LKESLNLEDQIESDESELKKLKT 336
+K+ L Q++ +L ++++
Sbjct: 691 IKD---LTKQLQQARRKLDQVES 710
Score = 38.1 bits (87), Expect = 0.017
Identities = 51/263 (19%), Positives = 112/263 (42%), Gaps = 30/263 (11%)
Query: 215 NISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVE 274
N ++ + NE + V +I L++ K Y E DT + ++ +
Sbjct: 100 NFAKHISKTNETEQKVT---QILVELRSSTFPESANEKTYSESPYDT-----DCTKKFIS 151
Query: 275 KYEIYGDSVDCLPSCQLEV---QLYQKKIQDLSDNREKLASILKESLNLEDQIESDESEL 331
K + S D L + E+ + + ++ + N+ + A +L E ++D+ E +
Sbjct: 152 KIKSVSASEDLLEEIESELLSTEFAEHRVPN-GMNKGEHALVLFEKC-VQDKYLQQEHII 209
Query: 332 KKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTV------IEDCNK-VQEKR 384
KKL E + L + + + ++ K+ E KQ+ T+ IE+ NK V+ R
Sbjct: 210 KKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASR 269
Query: 385 GAVYERVTTINQEIQKIKLGIQQLKDAAER--EKLKSQEIFLNLKTA--------LEKYH 434
+ + T +Q++ + Q + A + E+ + ++ + +K L K
Sbjct: 270 DQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEK 329
Query: 435 DGIEKAAEDSYAKIDEKTAELKR 457
+ +EK D+ ++++ T ++K+
Sbjct: 330 ETLEKKLRDANKELEKNTNKIKQ 352
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 61.2 bits (147), Expect = 2e-09
Identities = 68/336 (20%), Positives = 155/336 (46%), Gaps = 35/336 (10%)
Query: 151 KMQQLNAAHQEALMKLERLDSVPV-EEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGN 209
K++ A+HQ+A+ +L+ S + E EF +L I++++ D+ + LQ
Sbjct: 580 KLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRL----DYQHEIENLQNQQ 635
Query: 210 SQKKSNISEKTKRLNELKLSVVSLKEIQ-ESLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268
+++ +++ + L + V+ KE E++++K+ + ++ + +M+DT+ KL+ A
Sbjct: 636 DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQ---HLVEMEDTLNKLQEA 692
Query: 269 RQEVVEKYEIYG---DSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIE 325
+V E + + + + +++ ++K+ DL R+ + E L Q+E
Sbjct: 693 EIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE 752
Query: 326 SDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHE---DVKQYKRTVIEDCNKVQE 382
+ E ++K L+ E+N+ +L + K+ E +V Q K T+ ++ ++E
Sbjct: 753 AAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE 812
Query: 383 KRGAVYERVTTINQEIQK--------------IKLGIQQLK------DAAEREKLKSQEI 422
K E ++ + +Q+ + +++L+ +A REK + +E
Sbjct: 813 KFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQ 872
Query: 423 FLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRK 458
+ K LE I K + D+ +++ + EL+ K
Sbjct: 873 LIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK 908
Score = 55.1 bits (131), Expect = 1e-07
Identities = 92/443 (20%), Positives = 186/443 (41%), Gaps = 77/443 (17%)
Query: 72 EVMYPHLMEGFLPFSNLVTHLDSFLPICRVNDFETADILCPKAKRTSRFLSGIINFIHFR 131
E+ +L E S + L+ L I + E ++ +A R + +N +H +
Sbjct: 783 ELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASE----EAVSVQRSMQETVNKLHQK 838
Query: 132 EA-----------CRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF 180
E RE + +++ ++ +QL A ++ + + + + +
Sbjct: 839 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL 898
Query: 181 KQLSD-------GIQELQQSL-----NQDFHQKTI----VLQEGNSQKKSNISEKTKRLN 224
+++D ++ELQ L N F QK+I V E + Q+ + E+ K+
Sbjct: 899 TKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL 958
Query: 225 ELKLSVVSLK------EIQE----------SLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268
E KLS + K + QE KTK E L+N ++ + DT KLK A
Sbjct: 959 ERKLSDLEKKMETSHNQCQELKARYERATSETKTK---HEEILQNLQKTLLDTEDKLKGA 1015
Query: 269 RQE------VVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLED 322
R+E +E+ D + + +Q+ ++ ++ ++ L + + L++
Sbjct: 1016 REENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQN 1075
Query: 323 QIES-DESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQ 381
++++ E+ LK ++ E N K L+ V+ +K+ + K+ E +KQ + + +Q
Sbjct: 1076 ELDTLKENNLKNVE-ELNKSKELLTVENQKME----EFRKEIETLKQAAAQKSQQLSALQ 1130
Query: 382 EKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKY-------H 434
E+ + E + E+ Q+L++ ER L +Q L +K K+
Sbjct: 1131 EENVKLAEELGRSRDEV----TSHQKLEE--ERSVLNNQ--LLEMKKRESKFIKDADEEK 1182
Query: 435 DGIEKAAEDSYAKIDEKTAELKR 457
++K+ + A + EK AEL++
Sbjct: 1183 ASLQKSISITSALLTEKDAELEK 1205
Score = 50.8 bits (120), Expect = 3e-06
Identities = 67/355 (18%), Positives = 157/355 (44%), Gaps = 31/355 (8%)
Query: 132 EACRETYMEFLWQYKSSADKMQ-QLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQEL 190
EA R M+ + + ++S + ++ +L+ A + L+++E D++ ++ E K ++EL
Sbjct: 647 EALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME--DTLNKLQEAEIK-----VKEL 699
Query: 191 QQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEK 250
+ L +++T V+ SQ K+ EK L+ L+ + K + L+ ++ + ++
Sbjct: 700 EV-LQAKCNEQTKVIDNFTSQLKAT-EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQ 757
Query: 251 LKNYK-------EKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDL 303
+K+ + K ++L+ ++ E + + + E+Q+ ++K +
Sbjct: 758 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 817
Query: 304 SDNREKLASILKESLNL----EDQIESDESELKKLKT----------EENSFKRLMIVKK 349
S+ + ++E++N E+Q S+L+KL+ E++ + +I K
Sbjct: 818 SEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAK 877
Query: 350 EKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLK 409
EKL +I K D + ++ + + ++T N+ ++ I+ +
Sbjct: 878 EKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMT 937
Query: 410 DAAEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMST 464
AE+ + ++ + K LE+ +EK E S+ + E A +R + T
Sbjct: 938 VKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT 992
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 61.2 bits (147), Expect = 2e-09
Identities = 68/336 (20%), Positives = 155/336 (46%), Gaps = 35/336 (10%)
Query: 151 KMQQLNAAHQEALMKLERLDSVPV-EEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGN 209
K++ A+HQ+A+ +L+ S + E EF +L I++++ D+ + LQ
Sbjct: 615 KLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRL----DYQHEIENLQNQQ 670
Query: 210 SQKKSNISEKTKRLNELKLSVVSLKEIQ-ESLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268
+++ +++ + L + V+ KE E++++K+ + ++ + +M+DT+ KL+ A
Sbjct: 671 DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQ---HLVEMEDTLNKLQEA 727
Query: 269 RQEVVEKYEIYG---DSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIE 325
+V E + + + + +++ ++K+ DL R+ + E L Q+E
Sbjct: 728 EIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE 787
Query: 326 SDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHE---DVKQYKRTVIEDCNKVQE 382
+ E ++K L+ E+N+ +L + K+ E +V Q K T+ ++ ++E
Sbjct: 788 AAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE 847
Query: 383 KRGAVYERVTTINQEIQK--------------IKLGIQQLK------DAAEREKLKSQEI 422
K E ++ + +Q+ + +++L+ +A REK + +E
Sbjct: 848 KFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQ 907
Query: 423 FLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRK 458
+ K LE I K + D+ +++ + EL+ K
Sbjct: 908 LIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK 943
Score = 55.1 bits (131), Expect = 1e-07
Identities = 92/443 (20%), Positives = 186/443 (41%), Gaps = 77/443 (17%)
Query: 72 EVMYPHLMEGFLPFSNLVTHLDSFLPICRVNDFETADILCPKAKRTSRFLSGIINFIHFR 131
E+ +L E S + L+ L I + E ++ +A R + +N +H +
Sbjct: 818 ELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASE----EAVSVQRSMQETVNKLHQK 873
Query: 132 EA-----------CRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF 180
E RE + +++ ++ +QL A ++ + + + + +
Sbjct: 874 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL 933
Query: 181 KQLSD-------GIQELQQSL-----NQDFHQKTI----VLQEGNSQKKSNISEKTKRLN 224
+++D ++ELQ L N F QK+I V E + Q+ + E+ K+
Sbjct: 934 TKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL 993
Query: 225 ELKLSVVSLK------EIQE----------SLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268
E KLS + K + QE KTK E L+N ++ + DT KLK A
Sbjct: 994 ERKLSDLEKKMETSHNQCQELKARYERATSETKTK---HEEILQNLQKTLLDTEDKLKGA 1050
Query: 269 RQE------VVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLED 322
R+E +E+ D + + +Q+ ++ ++ ++ L + + L++
Sbjct: 1051 REENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQN 1110
Query: 323 QIES-DESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQ 381
++++ E+ LK ++ E N K L+ V+ +K+ + K+ E +KQ + + +Q
Sbjct: 1111 ELDTLKENNLKNVE-ELNKSKELLTVENQKME----EFRKEIETLKQAAAQKSQQLSALQ 1165
Query: 382 EKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKY-------H 434
E+ + E + E+ Q+L++ ER L +Q L +K K+
Sbjct: 1166 EENVKLAEELGRSRDEV----TSHQKLEE--ERSVLNNQ--LLEMKKRESKFIKDADEEK 1217
Query: 435 DGIEKAAEDSYAKIDEKTAELKR 457
++K+ + A + EK AEL++
Sbjct: 1218 ASLQKSISITSALLTEKDAELEK 1240
Score = 50.8 bits (120), Expect = 3e-06
Identities = 67/355 (18%), Positives = 157/355 (44%), Gaps = 31/355 (8%)
Query: 132 EACRETYMEFLWQYKSSADKMQ-QLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQEL 190
EA R M+ + + ++S + ++ +L+ A + L+++E D++ ++ E K ++EL
Sbjct: 682 EALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME--DTLNKLQEAEIK-----VKEL 734
Query: 191 QQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEK 250
+ L +++T V+ SQ K+ EK L+ L+ + K + L+ ++ + ++
Sbjct: 735 EV-LQAKCNEQTKVIDNFTSQLKAT-EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQ 792
Query: 251 LKNYK-------EKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDL 303
+K+ + K ++L+ ++ E + + + E+Q+ ++K +
Sbjct: 793 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 852
Query: 304 SDNREKLASILKESLNL----EDQIESDESELKKLKT----------EENSFKRLMIVKK 349
S+ + ++E++N E+Q S+L+KL+ E++ + +I K
Sbjct: 853 SEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAK 912
Query: 350 EKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLK 409
EKL +I K D + ++ + + ++T N+ ++ I+ +
Sbjct: 913 EKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMT 972
Query: 410 DAAEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMST 464
AE+ + ++ + K LE+ +EK E S+ + E A +R + T
Sbjct: 973 VKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT 1027
Score = 37.0 bits (84), Expect = 0.038
Identities = 73/355 (20%), Positives = 145/355 (40%), Gaps = 46/355 (12%)
Query: 132 EACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQ 191
EA +E L Q + K++ L +E E + +E Q + + I+EL+
Sbjct: 418 EAADREKVELLNQLEEEKRKVEDLQFRVEE-----ESITKGDLETQTKLEHAR--IKELE 470
Query: 192 QSLNQDFHQKTIVLQEGNSQKKSNISEKTKRL---NELKLSVVSLKEIQESLKT-KIVDS 247
QSL + + + +E + + +SEK++ + +L L V + E++ L++ K
Sbjct: 471 QSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGD 530
Query: 248 PEKLKNYKEKMKDTVQKLKNAR----QEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDL 303
+ + +++ +KL+ R +E+ E +G + + Q E++ + L
Sbjct: 531 VDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREE---THQKEIKALYTATEKL 587
Query: 304 SDNREKLASILKES------------LNLEDQIESDESELKKLKTEENSFKRLMIVKKEK 351
S E L S L+ + LE I S + +++LK SF + + + +
Sbjct: 588 SKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKV---SFSKGLGTETAE 644
Query: 352 LATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKI-------KLG 404
A + +I K D Y+ + N+ +R A + + + ++ K+
Sbjct: 645 FAELKTQIEKMRLD---YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEA 701
Query: 405 IQQLKDAAEREKLKSQEIFLNLKTALE---KYHDGIEKAAEDSYAKIDEKTAELK 456
I+ D AE + L E LN E K + ++ + ID T++LK
Sbjct: 702 IRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLK 756
>gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
Length = 718
Score = 61.2 bits (147), Expect = 2e-09
Identities = 57/308 (18%), Positives = 140/308 (45%), Gaps = 16/308 (5%)
Query: 133 ACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQ 192
A + Y++ Q K + +++ + +A +E + LD QEE L Q L +
Sbjct: 166 AGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLME 225
Query: 193 SLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLK 252
LNQ +++ NS + +L +L+ L+ ++ + + + +++
Sbjct: 226 RLNQSDS-----IEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEIS 280
Query: 253 NYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLAS 312
+++ D + L + Q + ++ ++ S D + + +V+ Y+KK++DL D R ++
Sbjct: 281 ELRQQ-NDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKL 339
Query: 313 ILKESLNLEDQIESDESELKK---LKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQY 369
+ +++ S E EL+K +++ ++KR ++ + +L+ K +K + K+
Sbjct: 340 LEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRL 399
Query: 370 KRTV---IEDCNKVQEKRGAVYERVTTIN----QEIQKIKLGIQQLKDAAEREKLKSQEI 422
K V ++ ++++ +R ++ E + + QE Q G+ L + L ++ +
Sbjct: 400 KEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIV 459
Query: 423 FLNLKTAL 430
++ L
Sbjct: 460 TPEIREKL 467
Score = 47.4 bits (111), Expect = 3e-05
Identities = 68/330 (20%), Positives = 148/330 (44%), Gaps = 34/330 (10%)
Query: 146 KSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQ---SLNQDFHQKT 202
+ S+DK+ +L + KLE L + + + K L + Q SL ++ +
Sbjct: 307 RHSSDKVSKLEGQVESYKKKLEDLGDL----RRQVKLLEEKNTMYMQNTVSLEEELRKAN 362
Query: 203 IVLQEGNSQKK------SNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKE 256
+ + K+ + +SE++K+ ++L LKE +SL+ + ++L+ ++
Sbjct: 363 AARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKE----KDRLRTERD 418
Query: 257 KMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKE 316
+K+T+++L+ + ++ ++ + L S + L + + + REKL + E
Sbjct: 419 SLKETIEELRCVQ---AQEGQLTTQGLMPLGSQESSDSLAAEIVTP--EIREKLIRLQHE 473
Query: 317 SLNLEDQIESDESE----LKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVK---QY 369
+ L+ E ++E L+ L + N K + + + ++ + E+++ Q
Sbjct: 474 NKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQD 533
Query: 370 KRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTA 429
+ + ED +++K E++ N E+QK + I+ L+ LK +E L+ A
Sbjct: 534 QGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEE----LQEA 589
Query: 430 LEKYHDGIEKAAEDSYAKIDEKTAELKRKM 459
L K + + K E+ Y K EK + R +
Sbjct: 590 LRKKEEEM-KQMEERYKKYLEKAKSVIRTL 618
Score = 34.3 bits (77), Expect = 0.25
Identities = 48/222 (21%), Positives = 104/222 (46%), Gaps = 30/222 (13%)
Query: 172 VPVEEQEEFKQLSDGI--QELQQSLNQDFHQKTIVL--QEGNSQKK-----SNISEKTKR 222
+P+ QE L+ I E+++ L + H+ ++ QEG+ +K S + + R
Sbjct: 443 MPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLR 502
Query: 223 LNEL----KLSVVSLKEIQ---ESLKTKIVDSPEKLKN---YKEKMKDTVQKLKNARQEV 272
NEL +L L E+Q E L+ + D K ++ K+K+++ ++KL A E+
Sbjct: 503 KNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNEL 562
Query: 273 VEKYEIYGDSVDCLPSCQLEVQLYQ----KKIQDLSDNREKLASILKESLNLEDQIESDE 328
+K I D + L+++ Q KK +++ E+ L+++ ++ ++ +
Sbjct: 563 QKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQ 622
Query: 329 S-----ELKKLKTEENSFKRLM--IVKKEKLATAQFKINKKH 363
+ E++ LK + RL + K+ + +Q ++ +K+
Sbjct: 623 NQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKY 664
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 60.8 bits (146), Expect = 2e-09
Identities = 77/332 (23%), Positives = 158/332 (47%), Gaps = 51/332 (15%)
Query: 152 MQQLNAAHQEALMKLER-LDSVPVEEQEEFKQLSDGIQELQQSLNQ-------DFHQKTI 203
++Q N A ++ L K+ + LD ++ + E IQ+L+Q L HQ
Sbjct: 2051 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110
Query: 204 VLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQ 263
V Q N ++ EKT + +EL LS +E L+ I + E++ EK++ V+
Sbjct: 2111 VEQLAN-----HLKEKTDKCSELLLS-------KEQLQRDIQERNEEI----EKLEFRVR 2154
Query: 264 KLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQ 323
+L+ A +VE + +G +V+ P LEVQL ++ D D +EK E NLE+Q
Sbjct: 2155 ELEQAL--LVEDRKHFG-AVEAKPELSLEVQLQAER--DAIDRKEK------EITNLEEQ 2203
Query: 324 IESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKH----EDVKQYKRTVIE-DCN 378
+E EL+ E + ++K++ T ++ +++ +D+++ + E D
Sbjct: 2204 LEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAM 2263
Query: 379 KVQEKR-------GAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQ-EIFLNLKTAL 430
Q++ + E+ I+Q +++ QQLK + + ++ + E+ +L+T +
Sbjct: 2264 STQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQI 2323
Query: 431 E---KYHDGIEKAAEDSYAKIDEKTAELKRKM 459
E + +++ E+ +++E +L++++
Sbjct: 2324 ECLMSDQECVKRNREEEIEQLNEVIEKLQQEL 2355
Score = 57.0 bits (136), Expect = 4e-08
Identities = 80/320 (25%), Positives = 149/320 (46%), Gaps = 43/320 (13%)
Query: 154 QLNAAHQEALMKLERLDSVPVEEQEEFKQLSD--GIQELQQ--SLNQDFHQKTIVLQEGN 209
QL +H+E L KL+ + + +E + ++L D GI QQ L + QK +Q
Sbjct: 628 QLLFSHEEELSKLK--EDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF-- 683
Query: 210 SQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNAR 269
+K N+ K N+L L + LK++Q+SL K + ++ + ++++ R
Sbjct: 684 --EKDNLITKQ---NQLILEISKLKDLQQSLVNS------KSEEMTLQINELQKEIEILR 732
Query: 270 QEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDL-SDNREKLASILKESLNLEDQIESDE 328
QE EK G + QL+ +L +K++++ +D +EK A + E+ L+D+ ++ E
Sbjct: 733 QEEKEK----GTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE 788
Query: 329 SELKKLKTEENSFKRLM----IVKKEKLATAQFKIN---KKHEDVKQYKRTVIEDCNKVQ 381
LK + T + +RL+ I K K + + +I +++ED+KQ + E+ K +
Sbjct: 789 DMLK-IHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQR 847
Query: 382 EKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQ-EIFLNLKTALEKYHDGIEKA 440
+ QE+Q+ + ++KD E K K + E LK E+ H
Sbjct: 848 NTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELH------ 901
Query: 441 AEDSYAKIDEKTAELKRKMF 460
+I+ T ++K +F
Sbjct: 902 ----LQRINPTTVKMKSSVF 917
Score = 53.9 bits (128), Expect = 3e-07
Identities = 62/318 (19%), Positives = 143/318 (44%), Gaps = 45/318 (14%)
Query: 147 SSADKMQ--QLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQE------------LQQ 192
++AD +Q Q HQ+ L + + L +++E+F +QE ++
Sbjct: 259 TAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVEN 318
Query: 193 SLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLK 252
S ++ +K +++E N++ I E+ K+ ELK + + ++ L+ +IV +++K
Sbjct: 319 SNKEEIQEKETIIEELNTK----IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIK 374
Query: 253 NYKEKMKDTVQKLKNARQEV------VEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDN 306
N K ++ ++ QK + + +E+ VE+ + Q E + Q+ Q+
Sbjct: 375 NMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHK-----DSQFETDIVQRMEQETQRK 429
Query: 307 REKLASILKESLN------LEDQIESDESELKKLKTE-----ENSFKRL--MIVKKEKLA 353
E+L + L E ++ I ++++++KT EN+ + + V ++++
Sbjct: 430 LEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK 489
Query: 354 TAQFKINK---KHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKD 410
IN+ K +D K + E+ + E++ A+ ++ + +E+ + IQ+ +
Sbjct: 490 LMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ 549
Query: 411 AAEREKLKSQEIFLNLKT 428
++ K E +L T
Sbjct: 550 TIAEQESKLNEAHKSLST 567
Score = 48.9 bits (115), Expect = 1e-05
Identities = 64/315 (20%), Positives = 136/315 (43%), Gaps = 24/315 (7%)
Query: 132 EACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERL-------DSVPVEEQEE-FKQL 183
E ++ +M+ Q K S ++Q+L ++ +E+L D++ ++Q F +
Sbjct: 2216 EEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKF 2275
Query: 184 SDGIQELQQSLNQDFHQKTIVLQEGNSQKKSN-ISEKTKRLNELKLSVVSLKEIQESLKT 242
+ IQE + ++Q Q T + Q+ + I EK + + +L+ + L QE +K
Sbjct: 2276 AQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKR 2335
Query: 243 KIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQK---- 298
+ E+L EK++ Q+L N Q+ + D L QL+V + +K
Sbjct: 2336 NREEEIEQLNEVIEKLQ---QELANIGQKTSMNAHSLSEEADSLKH-QLDVVIAEKLALE 2391
Query: 299 -KIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQF 357
+++ ++ + ++LKE+ +Q+ EL LK E S +++ + + + A
Sbjct: 2392 QQVETANEEMTFMKNVLKETNFKMNQL---TQELFSLKRERESVEKIQSIPENSVNVA-- 2446
Query: 358 KINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKL 417
I+ +D + + + ED K E + I ++ + QL+ + L
Sbjct: 2447 -IDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDL 2505
Query: 418 KSQEIFLNLKTALEK 432
+ + + +K E+
Sbjct: 2506 ELTQCYKQIKDMQEQ 2520
Score = 46.6 bits (109), Expect = 5e-05
Identities = 58/286 (20%), Positives = 126/286 (44%), Gaps = 52/286 (18%)
Query: 213 KSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDT----VQKLKNA 268
+S ++ K + EL +E++E T + ++L+ ++ +K Q N
Sbjct: 161 ESELAGKQHEIEELN------RELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANL 214
Query: 269 RQEVVEKYEIYGDSVDCLPSCQ-LEVQLYQKKIQDL------SDNREKLASILKESLNLE 321
+Q EK E + ++ Q L++Q Q + + S L ++ L +
Sbjct: 215 QQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274
Query: 322 DQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVK----QYKRTVIEDC 377
Q+E + L+ + ++ F + +EK+ + + +KK E+ Q K T+IE+
Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334
Query: 378 NK--VQEKR----------------GAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKS 419
N ++E++ G + E++ NQEI+ +KL +L ++ ++E+ S
Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKL---ELTNSKQKERQSS 391
Query: 420 QEI--FLNLKTALEKYH--------DGIEKAAEDSYAKIDEKTAEL 455
+EI + L+K + D +++ +++ K+++ AEL
Sbjct: 392 EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
Score = 45.1 bits (105), Expect = 1e-04
Identities = 70/320 (21%), Positives = 149/320 (46%), Gaps = 39/320 (12%)
Query: 151 KMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNS 210
+M+++ H+ + R S +++ K ++ I EL I LQ+ NS
Sbjct: 459 QMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN-----------IKLQDTNS 507
Query: 211 QKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQ 270
QK+ + E+ + E K + L+ E L ++ S E+++ ++ + + KL A +
Sbjct: 508 QKEK-LKEELGLILEEKCA---LQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHK 563
Query: 271 EVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQI-ESDES 329
+ ++ + V S + +L K ++++ + KL + KE + D++ ES E+
Sbjct: 564 SLSTVEDLKAEIVSASESRK---ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA 620
Query: 330 ELKKLKTEENSFKRLMIVKKEKLATAQFKINKKH----EDVK-----QYKRTVIEDCNKV 380
EL++L+T+ L+ +E+L+ + + +H E +K YK+ + N++
Sbjct: 621 ELERLRTQ------LLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEM 674
Query: 381 QEKRGAV-YERVTTINQEIQKIKLGIQQLKDAAER-EKLKSQEIFLNLKTALEKYHDGIE 438
+K + +E+ I ++ Q I L I +LKD + KS+E+ L + ++ I
Sbjct: 675 SQKIETMQFEKDNLITKQNQLI-LEISKLKDLQQSLVNSKSEEMTLQINELQKEIE--IL 731
Query: 439 KAAEDSYAKIDEKTAELKRK 458
+ E ++++ EL+ K
Sbjct: 732 RQEEKEKGTLEQEVQELQLK 751
Score = 43.1 bits (100), Expect = 5e-04
Identities = 69/310 (22%), Positives = 146/310 (47%), Gaps = 35/310 (11%)
Query: 149 ADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEG 208
AD+ QE ++RL+ + ++L Q++Q+ QK + E
Sbjct: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
Query: 209 NSQKKSNISEKTKRLNELKLSVVSLKE-----IQESLKTKIVDSPEKLKNYKEKMKDTVQ 263
++ + E T++L + KL V E +Q+ +K +D E++ + E ++
Sbjct: 1988 GPVEQQLLQE-TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNT 2046
Query: 264 KLKNARQE------VVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKES 317
+L + RQ+ +EK + D + + E ++Q++IQ L + + S
Sbjct: 2047 ELMDLRQQNQALEKQLEKMRKFLD--EQAIDREHERDVFQQEIQKLEQQLKVVPRFQPIS 2104
Query: 318 LNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVK--QYKRTVIE 375
+ ++E + LK+ KT++ S +++ KE+L Q I +++E+++ +++ +E
Sbjct: 2105 EHQTREVEQLANHLKE-KTDKCS---ELLLSKEQL---QRDIQERNEEIEKLEFRVRELE 2157
Query: 376 DCNKVQEKR--GAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKY 433
V++++ GAV E ++ E+Q +Q +DA +R K +EI NL+ LE++
Sbjct: 2158 QALLVEDRKHFGAV-EAKPELSLEVQ-----LQAERDAIDR---KEKEI-TNLEEQLEQF 2207
Query: 434 HDGIEKAAED 443
+ +E E+
Sbjct: 2208 REELENKNEE 2217
Score = 42.7 bits (99), Expect = 7e-04
Identities = 75/348 (21%), Positives = 148/348 (42%), Gaps = 65/348 (18%)
Query: 151 KMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNS 210
++Q+ +Q A+ L++ D + L IQ L +N +K + +E S
Sbjct: 3059 RIQEQGVEYQAAMECLQKADR---------RSLLSEIQALHAQMNG---RKITLKREQES 3106
Query: 211 QKKS------NISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQK 264
+K S NI +K ++ E+++ + S+K+ + + E+L + K + + +
Sbjct: 3107 EKPSQELLEYNIQQKQSQMLEMQVELSSMKD-------RATELQEQLSSEKMVVAELKSE 3159
Query: 265 LKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSD--------NREKLASILKE 316
L + E+ + + L + +LEV+ ++ L+D +RE ++ KE
Sbjct: 3160 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKE 3219
Query: 317 SLNLEDQIESDESELKKLKTEENSFKR-------LMIVKKEKLATAQFKINKK------- 362
L E D+ EL+ LK S K+ L+ +K+ L +Q KI +
Sbjct: 3220 KAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQ 3279
Query: 363 --HEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAE-REKLKS 419
E + + V+ + KV+ + E +T+++E +++ +Q + R L S
Sbjct: 3280 LSEEQGRNLELQVLLESEKVR-----IREMSSTLDRE-RELHAQLQSSDGTGQSRPPLPS 3333
Query: 420 QEIFLNLKTALEKYHDGI-EKAAEDSYAKID--------EKTAELKRK 458
+++ L+ LE+ H I E E K+D EK ++ RK
Sbjct: 3334 EDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRK 3381
Score = 39.7 bits (91), Expect = 0.006
Identities = 69/328 (21%), Positives = 139/328 (42%), Gaps = 53/328 (16%)
Query: 150 DKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGN 209
+K ++ QE L RL + E+Q+ IQE ++ L++ QK + E
Sbjct: 1940 EKTDIIDRLEQELLCASNRLQELEAEQQQ--------IQEERELLSR---QKEAMKAEAG 1988
Query: 210 SQKKSNISEKTKRLNELKLSVVSLKE-----IQESLKTKIVDSPEKLKNYKEKMKDTVQK 264
++ + E K + E KL V E +Q+ +K +D E++ + E ++ +
Sbjct: 1989 PVEQQLLQETEKLMKE-KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTE 2047
Query: 265 LKNARQE------VVEKYEIYGD--SVDCLPSCQLEVQLYQK---------KIQDLSDNR 307
L + RQ+ +EK + D ++D + Q QK + Q +S+++
Sbjct: 2048 LMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQ 2107
Query: 308 ----EKLASILKESLN-----------LEDQIESDESELKKLKTEENSFKRLMIVKKEK- 351
E+LA+ LKE + L+ I+ E++KL+ ++ ++V+ K
Sbjct: 2108 TREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKH 2167
Query: 352 LATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDA 411
+ K E Q +R I+ + +++ + E++ +E++ +QQL
Sbjct: 2168 FGAVEAKPELSLEVQLQAERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQ 2224
Query: 412 AEREKLKSQEIFLNLKTALEKYHDGIEK 439
E +K +S L+ + + D +EK
Sbjct: 2225 LEIQKKESTTRLQELEQENKLFKDDMEK 2252
Score = 33.9 bits (76), Expect = 0.32
Identities = 54/334 (16%), Positives = 144/334 (43%), Gaps = 30/334 (8%)
Query: 144 QYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQ----------- 192
Q +++ ++M + +E K+ +L +E K+ + ++++Q
Sbjct: 2393 QVETANEEMTFMKNVLKETNFKMNQL----TQELFSLKRERESVEKIQSIPENSVNVAID 2448
Query: 193 SLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLK----EIQESLKTKIVDSP 248
L++D + +VL E + N + K S+++L+ +++ ++ K ++
Sbjct: 2449 HLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELT 2508
Query: 249 EKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNR- 307
+ K K+ + + + ++++V +I + V Q++++ Q+ + DN+
Sbjct: 2509 QCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2568
Query: 308 ----EKLASILKESLNLEDQIESDESEL----KKLKTEENSFKRLMIVKKEKLATAQFKI 359
+ +I + ED++ SD S L +L+++ +I++KE++ A+ +
Sbjct: 2569 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2628
Query: 360 NKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKS 419
+K + + + ++ + + K +EK + + + ++ ++ E E L++
Sbjct: 2629 LEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRA 2688
Query: 420 QEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTA 453
+ + K L Y + EK E+ K T+
Sbjct: 2689 ESV--ATKAELASYKEKAEKLQEELLVKETNMTS 2720
Score = 30.8 bits (68), Expect = 2.7
Identities = 65/326 (19%), Positives = 140/326 (42%), Gaps = 44/326 (13%)
Query: 150 DKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEG- 208
D Q+L +QE E L + + E ++ + +QE + LN+ Q++ + E
Sbjct: 1589 DMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENL 1648
Query: 209 NSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268
S+++ + E+ + L +L L+ +E L ++ +S + +N E +
Sbjct: 1649 VSERERVLLEELEALKQLSLAG------REKLCCELRNSSTQTQNGNENQGE-------V 1695
Query: 269 RQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNR--EKLASILKESLNLEDQIES 326
++ ++ E+ D P E+ ++ ++NR + L ++K + +E+ I
Sbjct: 1696 EEQTFKEKELDRKPEDVPP----EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
Query: 327 DESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKH-----EDVKQYK-----RTVIED 376
+ ++ S L I + E A+ + ++++H E + Y R I
Sbjct: 1752 HVLGILDRSSKSQSSASL-IWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINM 1810
Query: 377 CNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDG 436
+KV E+ + +R+ ++ G + E E+L I L+ A+EK +
Sbjct: 1811 WSKVTEEGTELSQRL---------VRSGFAGTEIDPENEEL-MLNISSRLQAAVEKLLEA 1860
Query: 437 I-EKAAEDSYAKIDEKTAELKRKMFK 461
I E +++ +AK+ + EL R+ F+
Sbjct: 1861 ISETSSQLEHAKVTQ--TELMRESFR 1884
Score = 30.4 bits (67), Expect = 3.6
Identities = 47/254 (18%), Positives = 112/254 (44%), Gaps = 35/254 (13%)
Query: 175 EEQEEFKQLSDGIQELQQSLNQ---DFHQKTIVLQEGNSQKKSN---ISEKTKRLNELKL 228
E QEE+ L +L+ S N+ ++ K L E ++ N + K+ +E K
Sbjct: 863 ELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKT 922
Query: 229 SVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPS 288
V E+ E ++ + EKL+ K + + Q+L + +++ +K+
Sbjct: 923 FVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG----------- 971
Query: 289 CQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESE-LKKLKTEENSFKRLMIV 347
E+ ++++ L +E+++ +E LE I + +E ++ T+ +S ++
Sbjct: 972 ---EISFLNEEVKSLKQEKEQVSLRCRE---LEIIINHNRAENVQSCDTQVSSLLDGVVT 1025
Query: 348 KKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQ 407
+ A+ ++K ++ + + ++ED KV +E + T+ +E ++ +L +
Sbjct: 1026 MTSR--GAEGSVSKVNKSFGEESKIMVED--KVS------FENM-TVGEESKQEQLILDH 1074
Query: 408 LKDAAEREKLKSQE 421
L + L++ +
Sbjct: 1075 LPSVTKESSLRATQ 1088
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 60.8 bits (146), Expect = 2e-09
Identities = 65/326 (19%), Positives = 160/326 (49%), Gaps = 12/326 (3%)
Query: 139 MEFLWQYKSS--ADKMQQLNA--AHQEALMKLERLDSVPVEEQ-EEFKQLSDGIQELQQS 193
+E +++K+S + + +++NA A+QE+ + RL V + ++ EE ++ + +Q+ ++
Sbjct: 299 LEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEE 358
Query: 194 LNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKN 253
L Q+ K + GNS + + KR+ E++ + + + + ++ ++ ++
Sbjct: 359 L-QELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCR-ELRKKLQEEEH 416
Query: 254 YKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASI 313
+ ++++ V+KL+ E+ + E + S L ++ + +DL + E + S
Sbjct: 417 HSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSR 476
Query: 314 LKESLNLEDQIESDESELKKLKTEENSFKRLMIVKK----EKLATAQFKINKKHEDVKQY 369
+KE E ++E E LK T+ SF +++ ++ EK+ + K++ +++ K
Sbjct: 477 VKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVE 536
Query: 370 KRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTA 429
+ V++ K+ E+ + + + + +++ + +L + E+ KS E+ ++
Sbjct: 537 QGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSV-DL 595
Query: 430 LEKYHDGIEKAAEDSYAKIDEKTAEL 455
L+K DGIE+ + K +EL
Sbjct: 596 LKKRLDGIEEVEREITRGRSRKGSEL 621
Score = 50.4 bits (119), Expect = 3e-06
Identities = 62/316 (19%), Positives = 131/316 (41%), Gaps = 40/316 (12%)
Query: 145 YKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIV 204
Y+ +++ H+ + +LE + ++ SD L L Q+ + +
Sbjct: 162 YRRMLEQLLLAEKCHRRTVYELEN----EKHKHTDYMNKSDDFTNL---LEQERERLKKL 214
Query: 205 LQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESL--------------KTKIVDSPEK 250
L++ + + E KRLN+L+ +V LK L K+ D +K
Sbjct: 215 LEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQK 274
Query: 251 LKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKL 310
L+ +EK+K K K RQ++++ VD Q +++ L++
Sbjct: 275 LREEEEKLKAITSKSKEDRQKLLKL------EVDFEHKASRFSQEHEEMNAKLANQESHN 328
Query: 311 ASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYK 370
+ + + L +IE E K L+ E + L ++K+A + + +V+ +
Sbjct: 329 RQLRLKLVGLTQRIEELEETNKNLQKAEEELQEL----RDKIAKGECGNSSLMAEVENLR 384
Query: 371 RTVI------EDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQL-KDAAEREKLKSQEIF 423
+ V+ E+ K + + + +++ ++++L +++L K +E EKL +E F
Sbjct: 385 KRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKL--EEAF 442
Query: 424 LNLKTALEKYHDGIEK 439
K+ + H +EK
Sbjct: 443 SKSKSECTQLHLNLEK 458
Score = 50.4 bits (119), Expect = 3e-06
Identities = 64/364 (17%), Positives = 154/364 (42%), Gaps = 26/364 (7%)
Query: 114 AKRTSRFLSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVP 173
AKR ++ ++ F + + Q + K+Q L +E KL+ + S
Sbjct: 230 AKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKS 289
Query: 174 VEEQEEFKQLSDGIQELQQSLNQDFHQKTIVL---QEGNSQKKSNISEKTKRLNELKLSV 230
E++++ +L + +Q+ + L + N Q + + T+R+ EL+ +
Sbjct: 290 KEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETN 349
Query: 231 VSLKEIQESLK-------------TKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYE 277
+L++ +E L+ + ++ E L+ +M+ +++ + E +
Sbjct: 350 KNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRK 409
Query: 278 IYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTE 337
+ +LEV+ QK++ +L E + E L +E +++ K L E
Sbjct: 410 KLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNE 469
Query: 338 ENSFK---RLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTI 394
K + + + +L A+ + +K + ++++ + EK +V +
Sbjct: 470 LEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGL 529
Query: 395 NQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAKI---DEK 451
N+ K++ G ++ D E+ +S+++ L LK+ +E+ + + ++ K+ +EK
Sbjct: 530 NKNF-KVEQG--KVMDVTEKLIEESKKL-LKLKSEMEEKVYNLTRERDELIGKLKSEEEK 585
Query: 452 TAEL 455
++EL
Sbjct: 586 SSEL 589
Score = 42.0 bits (97), Expect = 0.001
Identities = 50/242 (20%), Positives = 105/242 (43%), Gaps = 26/242 (10%)
Query: 150 DKMQQLNAAHQEALMKLERLDSVPVE---EQEEFKQLSDGIQELQQSLNQDFHQK--TIV 204
+K+ L E + KL+ + E + K+ DGI+E+++ + + +K +
Sbjct: 563 EKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELT 622
Query: 205 LQEGNSQKKSN--ISEKTKRLNELKL---SVVSLKEIQESLKTKIVDSPEKLKNYKEKMK 259
E N K+ I KRL +L++ ++ ++ + L+ K +K ++++
Sbjct: 623 CPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLE 682
Query: 260 DTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLN 319
+ ++ A+ + +EK E+ + +LE + K +DL + L + E +N
Sbjct: 683 EIKHQI--AKNKAIEKGEVVSQEAELRHRFRLE----EAKSRDLKAEVQALKEKIHELMN 736
Query: 320 LED---QIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIED 376
ED Q++ D S L++ EE + K + + + K+ E K+Y R +
Sbjct: 737 KEDQLSQLQVDYSVLQQRFMEEEN-------KNKNMGQEVLNLTKELELSKRYSRALRPS 789
Query: 377 CN 378
N
Sbjct: 790 VN 791
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 60.5 bits (145), Expect = 3e-09
Identities = 62/317 (19%), Positives = 145/317 (45%), Gaps = 16/317 (5%)
Query: 149 ADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEG 208
A+K+Q+ + A + L+ + V+ Q+E KQL +QEL+ + +D Q T++ E
Sbjct: 1105 AEKLQKEQKIKEHATT-VNELEELQVQLQKEKKQLQKTMQELEL-VKKDAQQTTLMNMEI 1162
Query: 209 NSQKK------SNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTV 262
++ ++ K ++ +L+ + K+ QE+L+ +I ++ Y+EK
Sbjct: 1163 ADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIK 1222
Query: 263 QKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLED 322
Q L ++E+ + + D + S + E++ Q++++ + +LA I E + +
Sbjct: 1223 QLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVY---KIQLAEITSEKHKIHE 1279
Query: 323 QIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQE 382
+++ + ++ +++++ + +E+ A+ + + + YK + + K Q+
Sbjct: 1280 HLKTSAEQHQRTL---SAYQQRVTALQEECRAAKAEQATVTSEFESYK-VRVHNVLKQQK 1335
Query: 383 KRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDGIEKAAE 442
+ QE + +++ I QLK + + Q L+T L+ HD + +
Sbjct: 1336 NKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQT-LQSEHDTLLERHN 1394
Query: 443 DSYAKIDEKTAELKRKM 459
+ K AEL+ K+
Sbjct: 1395 KMLQETVSKEAELREKL 1411
Score = 49.7 bits (117), Expect = 6e-06
Identities = 59/294 (20%), Positives = 135/294 (45%), Gaps = 31/294 (10%)
Query: 140 EFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQE-----EFKQLSDGIQELQQS- 193
+F + + ++Q L HQ+ + +L E+++ E + L + + LQQ
Sbjct: 414 QFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEK 473
Query: 194 ----LNQDFHQKTI-VLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSP 248
LN + ++ + +LQ + IS++ + + + + S V E+Q+ L+T +
Sbjct: 474 QEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVH--ELQQKLRTAFTE-- 529
Query: 249 EKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNRE 308
K+ + +TV +L+ ++++ + E+ + + + + Q + +Y + LS
Sbjct: 530 ------KDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVY---LLSLSQRDT 580
Query: 309 KLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQ 368
L + + +L ++ + ++LK E ++F + K E+ ++ KK E Q
Sbjct: 581 MLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHK----KCEREERLILELGKKVEQTIQ 636
Query: 369 YKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEI 422
Y + + KV E G + E + +Q QK++ + Q+K +E +++ S E+
Sbjct: 637 YNSELEQ---KVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEV 687
Score = 48.1 bits (113), Expect = 2e-05
Identities = 65/306 (21%), Positives = 131/306 (42%), Gaps = 43/306 (14%)
Query: 152 MQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQ 211
+Q+ + E ++E L S PV E D I+ L + L+ +K Q+ S
Sbjct: 41 IQKAKSRCTELEKEIEELRSKPVTEGT-----GDIIKALTERLDALLLEKAETEQQCLSL 95
Query: 212 KKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQE 271
KK NI K +E+++S+ TK+ D+ ++L+ ++ LKN
Sbjct: 96 KKENIKMK--------------QEVEDSV-TKMGDAHKELEQSHINYVKEIENLKNELMA 140
Query: 272 VVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESEL 331
V KY D + QK++++ + + +L+ LK N ED ++ + E+
Sbjct: 141 VRSKYS--EDKANL-----------QKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEI 187
Query: 332 KKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERV 391
+K++ ++++ ++K+ AT ++K E V Q + + + Q+ ++ E +
Sbjct: 188 EKIR--PGFEEQILYLQKQLDATT----DEKKETVTQLQNIIEANSQHYQKNINSLQEEL 241
Query: 392 TTI----NQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAK 447
+ +E++++ I+ E E K E+ NL E I+K E
Sbjct: 242 LQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELEN 301
Query: 448 IDEKTA 453
+ + T+
Sbjct: 302 LRKATS 307
Score = 43.5 bits (101), Expect = 4e-04
Identities = 60/301 (19%), Positives = 129/301 (42%), Gaps = 21/301 (6%)
Query: 173 PVEEQEEFKQ-------LSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNE 225
P+ EQ+E + L D + + S+ D L+E + EK +++N+
Sbjct: 911 PLLEQKELRDRRAELILLKDSLAK-SPSVKNDPLSSVKELEEKIENLEKECKEKEEKINK 969
Query: 226 LKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDC 285
+KL V K+ +S + + E+L E ++ +L + +++++ E Y + +
Sbjct: 970 IKLVAVKAKKELDSSRKETQTVKEEL----ESLRSEKDQLSASMRDLIQGAESYKNLLLE 1025
Query: 286 LPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLM 345
++ + +++ + E L L+ S + I SD +L S +L+
Sbjct: 1026 YEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLL 1085
Query: 346 IVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGI 405
V+ ++ A+ ++K+ E K K K++E V E + + ++QK K +
Sbjct: 1086 EVQILEVQRAKAMVDKELEAEKLQKE------QKIKEHATTVNE-LEELQVQLQKEKKQL 1138
Query: 406 QQLKDAAEREKLKSQE-IFLNLKTA-LEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMS 463
Q+ E K +Q+ +N++ A E+ + + + KI++ E+K + K
Sbjct: 1139 QKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQE 1198
Query: 464 T 464
T
Sbjct: 1199 T 1199
Score = 43.1 bits (100), Expect = 5e-04
Identities = 66/326 (20%), Positives = 141/326 (43%), Gaps = 50/326 (15%)
Query: 144 QYKSSADKMQQ-LNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKT 202
Q S ++QQ L A E LE ++ + E ++ Q + + EL+ ++
Sbjct: 511 QQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQ-QELVPELENTIKN------ 563
Query: 203 IVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTV 262
LQE N ++S++ L EL+ + SL E ++ K+ +S E++ N+ +K +
Sbjct: 564 --LQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREE 621
Query: 263 QKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQL------YQKKIQDLSDNREKLASILKE 316
+ + ++V + + + +LE ++ ++ +++ N +KL ++ +
Sbjct: 622 RLILELGKKVEQTIQY---------NSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQ 672
Query: 317 SLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVI-- 374
L + E +E+K L E N KL++ + ++++ E K VI
Sbjct: 673 MKVLSEDKEVLSAEVKSLYEENN-----------KLSSEKKQLSRDLEVFLSQKEDVILK 721
Query: 375 EDCNKVQEKRGAVYERVTTI-----NQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTA 429
E ++++K + E + N+++QK+ + Q E S++ +
Sbjct: 722 EHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSED-------S 774
Query: 430 LEKYHDGIEKAAEDSYAKIDEKTAEL 455
EK + +A +S AKI+E+ L
Sbjct: 775 EEKDVVNVLQAVGESLAKINEEKCNL 800
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 60.1 bits (144), Expect = 4e-09
Identities = 66/321 (20%), Positives = 140/321 (43%), Gaps = 20/321 (6%)
Query: 142 LWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQS--LNQDFH 199
L +YK ++Q + + KLE DS+ V+ +E +Q+LQQ LN D
Sbjct: 711 LKEYKEKYLSLEQKTEELEGQIKKLEA-DSLEVKASKE-----QALQDLQQQRQLNTDLE 764
Query: 200 QKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMK 259
+ L + +K +S +L + E ES+K K+ E+ + K+ +
Sbjct: 765 LRATELSKQLEMEKEIVSST-------RLDLQKKSEALESIKQKLTKQEEEKQILKQDFE 817
Query: 260 DTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLN 319
Q+ K +E+ + + +V L ++E + ++ + D K++ LK S +
Sbjct: 818 TLSQETKIQHEELNNRIQT---TVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKS 874
Query: 320 -LEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCN 378
E + + ++ + L+ K + V+ E Q ++ K E K+ + + N
Sbjct: 875 EFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELN 934
Query: 379 KVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDGIE 438
+QE+ + +E Q+++ I +LK ++E++K + + + LK A+ + + +E
Sbjct: 935 SMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTE-LE 993
Query: 439 KAAEDSYAKIDEKTAELKRKM 459
+ + ++ A K K+
Sbjct: 994 NKLQQQLTQAAQELAAEKEKI 1014
Score = 53.5 bits (127), Expect = 4e-07
Identities = 70/368 (19%), Positives = 157/368 (42%), Gaps = 53/368 (14%)
Query: 138 YMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSD------------ 185
Y++ L + KSS +++ Q N E L+K E+ D +EE+ + +S
Sbjct: 286 YVQELQKLKSSVNELTQKNQTLTENLLKKEQ-DYTKLEEKHNEESVSKKNIQATLHQKDL 344
Query: 186 GIQELQQSLNQD------FHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQES 239
Q+LQ L+ H + E + K +SE + LK L++ +E
Sbjct: 345 DCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE 404
Query: 240 LKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYG----DSVDCLPSCQLEVQL 295
+ + ++ K+ +T ++L A + E+ ++ D + QL++
Sbjct: 405 KEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSR 464
Query: 296 YQKKIQDLSDNREKLASIL-KESLNLEDQIESDESELKKLKTEENSFKRLMIV---KKEK 351
++++++ N +L L K ++Q +S KL+ +N ++++ K +K
Sbjct: 465 LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK 524
Query: 352 LATAQFKINKKHEDVKQYKRTVIED--------------CNKVQEKRGAVYERVTTINQE 397
+ + + K E++ ++ ED N++QEK + E+VT + ++
Sbjct: 525 IQNLEALLQKSKENISLLEKE-REDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK 583
Query: 398 I----QKIKLGIQQLKDAAEREKL---KSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDE 450
+ + K + L D + +K +Q+ L+L+T++ + + + ++ E K+ +
Sbjct: 584 LKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKE----KVSQ 639
Query: 451 KTAELKRK 458
++K K
Sbjct: 640 LDIQIKAK 647
Score = 53.5 bits (127), Expect = 4e-07
Identities = 62/334 (18%), Positives = 137/334 (41%), Gaps = 38/334 (11%)
Query: 154 QLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKK 213
++N H + L +L +E+ + S+ + + +Q + D K L+E +K
Sbjct: 415 EINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQV-ADLQLKLSRLEEQLKEKV 473
Query: 214 SNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKN------ 267
+N +E +L++ K + +Q+S K+ ++ L+ ++ D QK++N
Sbjct: 474 TNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQ 533
Query: 268 -----------ARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKE 316
R+++ K + L Q + Q+++ L++ + + K+
Sbjct: 534 KSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQ 593
Query: 317 SL-NLEDQIESDESELK-------KLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQ 368
+ NL DQ++ ++ L+ L+T N + KEK++ +I K E +
Sbjct: 594 AQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS 653
Query: 369 YKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKT 428
+ +Q + QE+ KI + Q+ + QE L++
Sbjct: 654 AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ----DKQEHCSQLES 709
Query: 429 ALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKM 462
L++Y ++ Y +++KT EL+ ++ K+
Sbjct: 710 HLKEY--------KEKYLSLEQKTEELEGQIKKL 735
Score = 52.4 bits (124), Expect = 9e-07
Identities = 55/290 (18%), Positives = 134/290 (46%), Gaps = 14/290 (4%)
Query: 169 LDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIV-LQEGNSQKKSNISEKTKRLNELK 227
+D++ +E + E ++L D ++LQ + TI L+ ++ ++ + L +LK
Sbjct: 237 MDNMTLERERESEKLKDECKKLQSQYASS--EATISQLRSELAKGPQEVAVYVQELQKLK 294
Query: 228 LSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLP 287
SV L + ++L ++ + +EK + KN + + +K +DC
Sbjct: 295 SSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQK------DLDCQ- 347
Query: 288 SCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIV 347
QL+ +L + L +L+ + + L++++ E++ + LK E ++
Sbjct: 348 --QLQSRLSASETS-LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE 404
Query: 348 KKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQ 407
K++ Q +IN+ H + + +R + E +++E+R E++ Q++ ++L + +
Sbjct: 405 KEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSR 464
Query: 408 LKDAAEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKR 457
L++ + + S E+ L ++ H + + + AK+ E +L++
Sbjct: 465 LEEQLKEKVTNSTELQHQLDKT-KQQHQEQQALQQSTTAKLREAQNDLEQ 513
Score = 51.6 bits (122), Expect = 1e-06
Identities = 65/340 (19%), Positives = 156/340 (45%), Gaps = 25/340 (7%)
Query: 144 QYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQ-KT 202
Q++ +++Q Q+ M+ E L + +++ ++SD ++ + ++ + K
Sbjct: 826 QHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKA 885
Query: 203 IVL------QEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKL----- 251
+L +E Q + + K ELK S+ KE LK ++ E+L
Sbjct: 886 AILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQN 945
Query: 252 ---KNYKEK--MKDTVQKLKNARQEVVEKYE-IYGD-SVDCLPSCQLEVQLYQKKIQDLS 304
+N KE+ ++ + +LK + ++ ++ E + G+ + L +LE +L Q+ L+
Sbjct: 946 TLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ----LT 1001
Query: 305 DNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHE 364
++LA+ ++ L++ E + K+L+++ + ++ ++ L + + K++ E
Sbjct: 1002 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061
Query: 365 DVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFL 424
D+ + + +QE + A ++ Q+++ + L+D + + LK +E+ +
Sbjct: 1062 DLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL-V 1120
Query: 425 NLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMST 464
N K+ L + + I+ E K++E+ K + K T
Sbjct: 1121 NEKSKLAEIEE-IKCRQEKEITKLNEELKSHKLESIKEIT 1159
Score = 49.3 bits (116), Expect = 7e-06
Identities = 70/334 (20%), Positives = 147/334 (44%), Gaps = 35/334 (10%)
Query: 145 YKSSADKMQQLNAAH--QEALMKLERLDSVPVEEQEEFKQ--LSDGIQEL--QQSLNQDF 198
Y+ S + +QL + +E+ + R D VEE+ Q L ++ Q L Q+
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
Query: 199 HQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQ-ESLKTKIVDSPEKLKNYKEK 257
L++ +++K+ + E+ K L +++ SLKE + + K+K+ + E +++
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEK-SLKEKELVNEKSKLAEIEEIKCRQEKE 1139
Query: 258 MKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKES 317
+ ++LK+ + E +++ D+ L +LE+Q ++ + ++ ILK+
Sbjct: 1140 ITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQ 1199
Query: 318 LNLEDQ--------------IESDESELKKLKTEENSFKRLM----------IVKKEKLA 353
+ E++ E E E+ K EEN K M VKKE +
Sbjct: 1200 VKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQS 1259
Query: 354 TAQ--FKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDA 411
+ + ++ K+ +D++ + Q++R A+ ER EI+K++ + +L+
Sbjct: 1260 SQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRK 1319
Query: 412 AEREKLKSQEIFLNLKTALEKYHDGI-EKAAEDS 444
+ QE+ ++ K+ + K AED+
Sbjct: 1320 LDNTTAAVQELGRENQSLQIKHTQALNRKWAEDN 1353
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 60.1 bits (144), Expect = 4e-09
Identities = 54/277 (19%), Positives = 130/277 (46%), Gaps = 39/277 (14%)
Query: 153 QQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQK 212
+ ++ A E LM+L + E D + E++ ++ ++ T + Q ++QK
Sbjct: 677 EYIHKAEHEKLMQLTNVSRAKAE---------DALSEMKSQYSKVLNELTQLKQLVDAQK 727
Query: 213 KSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEV 272
++++S + ++ +L+T + EK+ N KE + ++ +++
Sbjct: 728 ENSVS------------ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQL 775
Query: 273 VEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESD----E 328
+E+ D++ + Y+K L LAS LKES+ ++++ S+
Sbjct: 776 LEEKAAMTDAM-------VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIR 828
Query: 329 SELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVY 388
SE+ ++K E+ + + L+ K++++ K + E++ + KR E +K++E +
Sbjct: 829 SEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKR-YAESSSKLEEDKD--- 884
Query: 389 ERVTTINQEIQKIK---LGIQQLKDAAEREKLKSQEI 422
+++ +++E+ K+K + QL + K +SQ++
Sbjct: 885 KKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL 921
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/310 (22%), Positives = 126/310 (40%), Gaps = 39/310 (12%)
Query: 148 SADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIV--L 205
S K +L E++ + V E EE L Q+LQ +L + K V L
Sbjct: 504 SVQKQMKLGLVSPESMDNYSHFHELRVTE-EEINVLK---QDLQNALEESERNKEKVREL 559
Query: 206 QEG--NSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTV- 262
+E +K + I + E+K S S+ E K + + ++ + K+KDT+
Sbjct: 560 EEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLK 619
Query: 263 -QKLKNARQEVVEKYEIYGDSVDCLPSCQLEV-QLYQKKIQDLSDNR------------- 307
Q + A E + E +D L E+ QLY++ +L D R
Sbjct: 620 SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 679
Query: 308 -----EKLASILKES-LNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINK 361
EKL + S ED + +S+ K+ E K+L+ +KE +
Sbjct: 680 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI-----T 734
Query: 362 KHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQE 421
+H V RT ++ ++EK + E + + E+ K++ + + K AA + + +
Sbjct: 735 EHLQVITTLRTAAKE---MEEKISNLKEHLASKEVEVAKLEKQLLEEK-AAMTDAMVPRS 790
Query: 422 IFLNLKTALE 431
+ L+++LE
Sbjct: 791 SYEKLQSSLE 800
Score = 35.8 bits (81), Expect = 0.085
Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 30/164 (18%)
Query: 146 KSSADKMQQ--------LNAAHQEALMKLERLDSVPVEEQEEFKQLS---DGIQELQQSL 194
+SS +K+Q L + +E++ + E++ S V+ + E Q+ + IQ L +S
Sbjct: 789 RSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSK 848
Query: 195 NQDFHQKTIVLQEGN---------SQKKSNISE-KTKRLNELKLSVVSLKEIQESLKTKI 244
Q+ ++ Q+ ++ S + E K K++NE+ V LKE SL
Sbjct: 849 EQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 908
Query: 245 VDSP---------EKLKNYKEKMKDTVQKLKNARQEVVEKYEIY 279
+ E L+ +++++ + + K QEV+ Y ++
Sbjct: 909 YSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMH 952
Score = 35.4 bits (80), Expect = 0.11
Identities = 58/291 (19%), Positives = 119/291 (40%), Gaps = 51/291 (17%)
Query: 214 SNISEKTKRLNELKLSVVSLKEI-----QESLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268
S+I E RL++ SL +I Q+ L + + L + ++++D +Q
Sbjct: 320 SSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPK 379
Query: 269 RQEVVEKYEIY-------GDSV---------DCLPSCQLEVQLYQKKIQDLSDNREKLAS 312
E ++ Y G S+ D S + + K D ++L
Sbjct: 380 EAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQE 439
Query: 313 ILKESLNLEDQIESDESELKKLKTEENSFK-RLMIVKKEKLATAQFKINKKHEDVKQYKR 371
IL++ L+ ++ES E+E K+L+ E S + L+ + +++ +++K ++ +
Sbjct: 440 ILQD---LQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYE 496
Query: 372 TVIEDCNKVQE--KRGAV----------YERVTTINQEIQKIKLGIQQLKDAAEREKLKS 419
+++ VQ+ K G V + + +EI +K +Q + +ER K K
Sbjct: 497 EAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKV 556
Query: 420 QEIFLNL---------KTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFK 461
+E+ L K +E+Y + + SY + E + K +F+
Sbjct: 557 RELEEKLVEREKGTVIKPPVEEYEE-----MKSSYCSVIENMNKEKAFLFE 602
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 60.1 bits (144), Expect = 4e-09
Identities = 54/277 (19%), Positives = 130/277 (46%), Gaps = 39/277 (14%)
Query: 153 QQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQK 212
+ ++ A E LM+L + E D + E++ ++ ++ T + Q ++QK
Sbjct: 666 EYIHKAEHEKLMQLTNVSRAKAE---------DALSEMKSQYSKVLNELTQLKQLVDAQK 716
Query: 213 KSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEV 272
++++S + ++ +L+T + EK+ N KE + ++ +++
Sbjct: 717 ENSVS------------ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQL 764
Query: 273 VEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESD----E 328
+E+ D++ + Y+K L LAS LKES+ ++++ S+
Sbjct: 765 LEEKAAMTDAM-------VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIR 817
Query: 329 SELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVY 388
SE+ ++K E+ + + L+ K++++ K + E++ + KR E +K++E +
Sbjct: 818 SEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKR-YAESSSKLEEDKD--- 873
Query: 389 ERVTTINQEIQKIK---LGIQQLKDAAEREKLKSQEI 422
+++ +++E+ K+K + QL + K +SQ++
Sbjct: 874 KKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL 910
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/310 (22%), Positives = 126/310 (40%), Gaps = 39/310 (12%)
Query: 148 SADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIV--L 205
S K +L E++ + V E EE L Q+LQ +L + K V L
Sbjct: 493 SVQKQMKLGLVSPESMDNYSHFHELRVTE-EEINVLK---QDLQNALEESERNKEKVREL 548
Query: 206 QEG--NSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTV- 262
+E +K + I + E+K S S+ E K + + ++ + K+KDT+
Sbjct: 549 EEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLK 608
Query: 263 -QKLKNARQEVVEKYEIYGDSVDCLPSCQLEV-QLYQKKIQDLSDNR------------- 307
Q + A E + E +D L E+ QLY++ +L D R
Sbjct: 609 SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 668
Query: 308 -----EKLASILKES-LNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINK 361
EKL + S ED + +S+ K+ E K+L+ +KE +
Sbjct: 669 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI-----T 723
Query: 362 KHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQE 421
+H V RT ++ ++EK + E + + E+ K++ + + K AA + + +
Sbjct: 724 EHLQVITTLRTAAKE---MEEKISNLKEHLASKEVEVAKLEKQLLEEK-AAMTDAMVPRS 779
Query: 422 IFLNLKTALE 431
+ L+++LE
Sbjct: 780 SYEKLQSSLE 789
Score = 35.8 bits (81), Expect = 0.085
Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 30/164 (18%)
Query: 146 KSSADKMQQ--------LNAAHQEALMKLERLDSVPVEEQEEFKQLS---DGIQELQQSL 194
+SS +K+Q L + +E++ + E++ S V+ + E Q+ + IQ L +S
Sbjct: 778 RSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSK 837
Query: 195 NQDFHQKTIVLQEGN---------SQKKSNISE-KTKRLNELKLSVVSLKEIQESLKTKI 244
Q+ ++ Q+ ++ S + E K K++NE+ V LKE SL
Sbjct: 838 EQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 897
Query: 245 VDSP---------EKLKNYKEKMKDTVQKLKNARQEVVEKYEIY 279
+ E L+ +++++ + + K QEV+ Y ++
Sbjct: 898 YSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMH 941
Score = 35.4 bits (80), Expect = 0.11
Identities = 58/291 (19%), Positives = 119/291 (40%), Gaps = 51/291 (17%)
Query: 214 SNISEKTKRLNELKLSVVSLKEI-----QESLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268
S+I E RL++ SL +I Q+ L + + L + ++++D +Q
Sbjct: 309 SSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPK 368
Query: 269 RQEVVEKYEIY-------GDSV---------DCLPSCQLEVQLYQKKIQDLSDNREKLAS 312
E ++ Y G S+ D S + + K D ++L
Sbjct: 369 EAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQE 428
Query: 313 ILKESLNLEDQIESDESELKKLKTEENSFK-RLMIVKKEKLATAQFKINKKHEDVKQYKR 371
IL++ L+ ++ES E+E K+L+ E S + L+ + +++ +++K ++ +
Sbjct: 429 ILQD---LQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYE 485
Query: 372 TVIEDCNKVQE--KRGAV----------YERVTTINQEIQKIKLGIQQLKDAAEREKLKS 419
+++ VQ+ K G V + + +EI +K +Q + +ER K K
Sbjct: 486 EAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKV 545
Query: 420 QEIFLNL---------KTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFK 461
+E+ L K +E+Y + + SY + E + K +F+
Sbjct: 546 RELEEKLVEREKGTVIKPPVEEYEE-----MKSSYCSVIENMNKEKAFLFE 591
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 60.1 bits (144), Expect = 4e-09
Identities = 54/277 (19%), Positives = 130/277 (46%), Gaps = 39/277 (14%)
Query: 153 QQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQK 212
+ ++ A E LM+L + E D + E++ ++ ++ T + Q ++QK
Sbjct: 645 EYIHKAEHEKLMQLTNVSRAKAE---------DALSEMKSQYSKVLNELTQLKQLVDAQK 695
Query: 213 KSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEV 272
++++S + ++ +L+T + EK+ N KE + ++ +++
Sbjct: 696 ENSVS------------ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQL 743
Query: 273 VEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESD----E 328
+E+ D++ + Y+K L LAS LKES+ ++++ S+
Sbjct: 744 LEEKAAMTDAM-------VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIR 796
Query: 329 SELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVY 388
SE+ ++K E+ + + L+ K++++ K + E++ + KR E +K++E +
Sbjct: 797 SEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKR-YAESSSKLEEDKD--- 852
Query: 389 ERVTTINQEIQKIK---LGIQQLKDAAEREKLKSQEI 422
+++ +++E+ K+K + QL + K +SQ++
Sbjct: 853 KKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL 889
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/310 (22%), Positives = 126/310 (40%), Gaps = 39/310 (12%)
Query: 148 SADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIV--L 205
S K +L E++ + V E EE L Q+LQ +L + K V L
Sbjct: 472 SVQKQMKLGLVSPESMDNYSHFHELRVTE-EEINVLK---QDLQNALEESERNKEKVREL 527
Query: 206 QEG--NSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTV- 262
+E +K + I + E+K S S+ E K + + ++ + K+KDT+
Sbjct: 528 EEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLK 587
Query: 263 -QKLKNARQEVVEKYEIYGDSVDCLPSCQLEV-QLYQKKIQDLSDNR------------- 307
Q + A E + E +D L E+ QLY++ +L D R
Sbjct: 588 SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 647
Query: 308 -----EKLASILKES-LNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINK 361
EKL + S ED + +S+ K+ E K+L+ +KE +
Sbjct: 648 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI-----T 702
Query: 362 KHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQE 421
+H V RT ++ ++EK + E + + E+ K++ + + K AA + + +
Sbjct: 703 EHLQVITTLRTAAKE---MEEKISNLKEHLASKEVEVAKLEKQLLEEK-AAMTDAMVPRS 758
Query: 422 IFLNLKTALE 431
+ L+++LE
Sbjct: 759 SYEKLQSSLE 768
Score = 35.8 bits (81), Expect = 0.085
Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 30/164 (18%)
Query: 146 KSSADKMQQ--------LNAAHQEALMKLERLDSVPVEEQEEFKQLS---DGIQELQQSL 194
+SS +K+Q L + +E++ + E++ S V+ + E Q+ + IQ L +S
Sbjct: 757 RSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSK 816
Query: 195 NQDFHQKTIVLQEGN---------SQKKSNISE-KTKRLNELKLSVVSLKEIQESLKTKI 244
Q+ ++ Q+ ++ S + E K K++NE+ V LKE SL
Sbjct: 817 EQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 876
Query: 245 VDSP---------EKLKNYKEKMKDTVQKLKNARQEVVEKYEIY 279
+ E L+ +++++ + + K QEV+ Y ++
Sbjct: 877 YSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMH 920
Score = 35.4 bits (80), Expect = 0.11
Identities = 58/291 (19%), Positives = 119/291 (40%), Gaps = 51/291 (17%)
Query: 214 SNISEKTKRLNELKLSVVSLKEI-----QESLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268
S+I E RL++ SL +I Q+ L + + L + ++++D +Q
Sbjct: 288 SSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPK 347
Query: 269 RQEVVEKYEIY-------GDSV---------DCLPSCQLEVQLYQKKIQDLSDNREKLAS 312
E ++ Y G S+ D S + + K D ++L
Sbjct: 348 EAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQE 407
Query: 313 ILKESLNLEDQIESDESELKKLKTEENSFK-RLMIVKKEKLATAQFKINKKHEDVKQYKR 371
IL++ L+ ++ES E+E K+L+ E S + L+ + +++ +++K ++ +
Sbjct: 408 ILQD---LQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYE 464
Query: 372 TVIEDCNKVQE--KRGAV----------YERVTTINQEIQKIKLGIQQLKDAAEREKLKS 419
+++ VQ+ K G V + + +EI +K +Q + +ER K K
Sbjct: 465 EAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKV 524
Query: 420 QEIFLNL---------KTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFK 461
+E+ L K +E+Y + + SY + E + K +F+
Sbjct: 525 RELEEKLVEREKGTVIKPPVEEYEE-----MKSSYCSVIENMNKEKAFLFE 570
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 60.1 bits (144), Expect = 4e-09
Identities = 54/277 (19%), Positives = 130/277 (46%), Gaps = 39/277 (14%)
Query: 153 QQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQK 212
+ ++ A E LM+L + E D + E++ ++ ++ T + Q ++QK
Sbjct: 674 EYIHKAEHEKLMQLTNVSRAKAE---------DALSEMKSQYSKVLNELTQLKQLVDAQK 724
Query: 213 KSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEV 272
++++S + ++ +L+T + EK+ N KE + ++ +++
Sbjct: 725 ENSVS------------ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQL 772
Query: 273 VEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESD----E 328
+E+ D++ + Y+K L LAS LKES+ ++++ S+
Sbjct: 773 LEEKAAMTDAM-------VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIR 825
Query: 329 SELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVY 388
SE+ ++K E+ + + L+ K++++ K + E++ + KR E +K++E +
Sbjct: 826 SEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKR-YAESSSKLEEDKD--- 881
Query: 389 ERVTTINQEIQKIK---LGIQQLKDAAEREKLKSQEI 422
+++ +++E+ K+K + QL + K +SQ++
Sbjct: 882 KKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL 918
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/310 (22%), Positives = 126/310 (40%), Gaps = 39/310 (12%)
Query: 148 SADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIV--L 205
S K +L E++ + V E EE L Q+LQ +L + K V L
Sbjct: 501 SVQKQMKLGLVSPESMDNYSHFHELRVTE-EEINVLK---QDLQNALEESERNKEKVREL 556
Query: 206 QEG--NSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTV- 262
+E +K + I + E+K S S+ E K + + ++ + K+KDT+
Sbjct: 557 EEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLK 616
Query: 263 -QKLKNARQEVVEKYEIYGDSVDCLPSCQLEV-QLYQKKIQDLSDNR------------- 307
Q + A E + E +D L E+ QLY++ +L D R
Sbjct: 617 SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 676
Query: 308 -----EKLASILKES-LNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINK 361
EKL + S ED + +S+ K+ E K+L+ +KE +
Sbjct: 677 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI-----T 731
Query: 362 KHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQE 421
+H V RT ++ ++EK + E + + E+ K++ + + K AA + + +
Sbjct: 732 EHLQVITTLRTAAKE---MEEKISNLKEHLASKEVEVAKLEKQLLEEK-AAMTDAMVPRS 787
Query: 422 IFLNLKTALE 431
+ L+++LE
Sbjct: 788 SYEKLQSSLE 797
Score = 35.8 bits (81), Expect = 0.085
Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 30/164 (18%)
Query: 146 KSSADKMQQ--------LNAAHQEALMKLERLDSVPVEEQEEFKQLS---DGIQELQQSL 194
+SS +K+Q L + +E++ + E++ S V+ + E Q+ + IQ L +S
Sbjct: 786 RSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSK 845
Query: 195 NQDFHQKTIVLQEGN---------SQKKSNISE-KTKRLNELKLSVVSLKEIQESLKTKI 244
Q+ ++ Q+ ++ S + E K K++NE+ V LKE SL
Sbjct: 846 EQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 905
Query: 245 VDSP---------EKLKNYKEKMKDTVQKLKNARQEVVEKYEIY 279
+ E L+ +++++ + + K QEV+ Y ++
Sbjct: 906 YSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMH 949
Score = 35.4 bits (80), Expect = 0.11
Identities = 58/291 (19%), Positives = 119/291 (40%), Gaps = 51/291 (17%)
Query: 214 SNISEKTKRLNELKLSVVSLKEI-----QESLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268
S+I E RL++ SL +I Q+ L + + L + ++++D +Q
Sbjct: 317 SSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPK 376
Query: 269 RQEVVEKYEIY-------GDSV---------DCLPSCQLEVQLYQKKIQDLSDNREKLAS 312
E ++ Y G S+ D S + + K D ++L
Sbjct: 377 EAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQE 436
Query: 313 ILKESLNLEDQIESDESELKKLKTEENSFK-RLMIVKKEKLATAQFKINKKHEDVKQYKR 371
IL++ L+ ++ES E+E K+L+ E S + L+ + +++ +++K ++ +
Sbjct: 437 ILQD---LQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYE 493
Query: 372 TVIEDCNKVQE--KRGAV----------YERVTTINQEIQKIKLGIQQLKDAAEREKLKS 419
+++ VQ+ K G V + + +EI +K +Q + +ER K K
Sbjct: 494 EAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKV 553
Query: 420 QEIFLNL---------KTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFK 461
+E+ L K +E+Y + + SY + E + K +F+
Sbjct: 554 RELEEKLVEREKGTVIKPPVEEYEE-----MKSSYCSVIENMNKEKAFLFE 599
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 60.1 bits (144), Expect = 4e-09
Identities = 54/277 (19%), Positives = 130/277 (46%), Gaps = 39/277 (14%)
Query: 153 QQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQK 212
+ ++ A E LM+L + E D + E++ ++ ++ T + Q ++QK
Sbjct: 674 EYIHKAEHEKLMQLTNVSRAKAE---------DALSEMKSQYSKVLNELTQLKQLVDAQK 724
Query: 213 KSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEV 272
++++S + ++ +L+T + EK+ N KE + ++ +++
Sbjct: 725 ENSVS------------ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQL 772
Query: 273 VEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESD----E 328
+E+ D++ + Y+K L LAS LKES+ ++++ S+
Sbjct: 773 LEEKAAMTDAM-------VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIR 825
Query: 329 SELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVY 388
SE+ ++K E+ + + L+ K++++ K + E++ + KR E +K++E +
Sbjct: 826 SEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKR-YAESSSKLEEDKD--- 881
Query: 389 ERVTTINQEIQKIK---LGIQQLKDAAEREKLKSQEI 422
+++ +++E+ K+K + QL + K +SQ++
Sbjct: 882 KKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL 918
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/310 (22%), Positives = 126/310 (40%), Gaps = 39/310 (12%)
Query: 148 SADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIV--L 205
S K +L E++ + V E EE L Q+LQ +L + K V L
Sbjct: 501 SVQKQMKLGLVSPESMDNYSHFHELRVTE-EEINVLK---QDLQNALEESERNKEKVREL 556
Query: 206 QEG--NSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTV- 262
+E +K + I + E+K S S+ E K + + ++ + K+KDT+
Sbjct: 557 EEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLK 616
Query: 263 -QKLKNARQEVVEKYEIYGDSVDCLPSCQLEV-QLYQKKIQDLSDNR------------- 307
Q + A E + E +D L E+ QLY++ +L D R
Sbjct: 617 SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 676
Query: 308 -----EKLASILKES-LNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINK 361
EKL + S ED + +S+ K+ E K+L+ +KE +
Sbjct: 677 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI-----T 731
Query: 362 KHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQE 421
+H V RT ++ ++EK + E + + E+ K++ + + K AA + + +
Sbjct: 732 EHLQVITTLRTAAKE---MEEKISNLKEHLASKEVEVAKLEKQLLEEK-AAMTDAMVPRS 787
Query: 422 IFLNLKTALE 431
+ L+++LE
Sbjct: 788 SYEKLQSSLE 797
Score = 35.8 bits (81), Expect = 0.085
Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 30/164 (18%)
Query: 146 KSSADKMQQ--------LNAAHQEALMKLERLDSVPVEEQEEFKQLS---DGIQELQQSL 194
+SS +K+Q L + +E++ + E++ S V+ + E Q+ + IQ L +S
Sbjct: 786 RSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSK 845
Query: 195 NQDFHQKTIVLQEGN---------SQKKSNISE-KTKRLNELKLSVVSLKEIQESLKTKI 244
Q+ ++ Q+ ++ S + E K K++NE+ V LKE SL
Sbjct: 846 EQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 905
Query: 245 VDSP---------EKLKNYKEKMKDTVQKLKNARQEVVEKYEIY 279
+ E L+ +++++ + + K QEV+ Y ++
Sbjct: 906 YSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMH 949
Score = 35.4 bits (80), Expect = 0.11
Identities = 58/291 (19%), Positives = 119/291 (40%), Gaps = 51/291 (17%)
Query: 214 SNISEKTKRLNELKLSVVSLKEI-----QESLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268
S+I E RL++ SL +I Q+ L + + L + ++++D +Q
Sbjct: 317 SSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPK 376
Query: 269 RQEVVEKYEIY-------GDSV---------DCLPSCQLEVQLYQKKIQDLSDNREKLAS 312
E ++ Y G S+ D S + + K D ++L
Sbjct: 377 EAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQE 436
Query: 313 ILKESLNLEDQIESDESELKKLKTEENSFK-RLMIVKKEKLATAQFKINKKHEDVKQYKR 371
IL++ L+ ++ES E+E K+L+ E S + L+ + +++ +++K ++ +
Sbjct: 437 ILQD---LQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYE 493
Query: 372 TVIEDCNKVQE--KRGAV----------YERVTTINQEIQKIKLGIQQLKDAAEREKLKS 419
+++ VQ+ K G V + + +EI +K +Q + +ER K K
Sbjct: 494 EAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKV 553
Query: 420 QEIFLNL---------KTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFK 461
+E+ L K +E+Y + + SY + E + K +F+
Sbjct: 554 RELEEKLVEREKGTVIKPPVEEYEE-----MKSSYCSVIENMNKEKAFLFE 599
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 60.1 bits (144), Expect = 4e-09
Identities = 54/277 (19%), Positives = 130/277 (46%), Gaps = 39/277 (14%)
Query: 153 QQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQK 212
+ ++ A E LM+L + E D + E++ ++ ++ T + Q ++QK
Sbjct: 674 EYIHKAEHEKLMQLTNVSRAKAE---------DALSEMKSQYSKVLNELTQLKQLVDAQK 724
Query: 213 KSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEV 272
++++S + ++ +L+T + EK+ N KE + ++ +++
Sbjct: 725 ENSVS------------ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQL 772
Query: 273 VEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESD----E 328
+E+ D++ + Y+K L LAS LKES+ ++++ S+
Sbjct: 773 LEEKAAMTDAM-------VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIR 825
Query: 329 SELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVY 388
SE+ ++K E+ + + L+ K++++ K + E++ + KR E +K++E +
Sbjct: 826 SEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKR-YAESSSKLEEDKD--- 881
Query: 389 ERVTTINQEIQKIK---LGIQQLKDAAEREKLKSQEI 422
+++ +++E+ K+K + QL + K +SQ++
Sbjct: 882 KKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL 918
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/310 (22%), Positives = 126/310 (40%), Gaps = 39/310 (12%)
Query: 148 SADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIV--L 205
S K +L E++ + V E EE L Q+LQ +L + K V L
Sbjct: 501 SVQKQMKLGLVSPESMDNYSHFHELRVTE-EEINVLK---QDLQNALEESERNKEKVREL 556
Query: 206 QEG--NSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTV- 262
+E +K + I + E+K S S+ E K + + ++ + K+KDT+
Sbjct: 557 EEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLK 616
Query: 263 -QKLKNARQEVVEKYEIYGDSVDCLPSCQLEV-QLYQKKIQDLSDNR------------- 307
Q + A E + E +D L E+ QLY++ +L D R
Sbjct: 617 SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 676
Query: 308 -----EKLASILKES-LNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINK 361
EKL + S ED + +S+ K+ E K+L+ +KE +
Sbjct: 677 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI-----T 731
Query: 362 KHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQE 421
+H V RT ++ ++EK + E + + E+ K++ + + K AA + + +
Sbjct: 732 EHLQVITTLRTAAKE---MEEKISNLKEHLASKEVEVAKLEKQLLEEK-AAMTDAMVPRS 787
Query: 422 IFLNLKTALE 431
+ L+++LE
Sbjct: 788 SYEKLQSSLE 797
Score = 35.8 bits (81), Expect = 0.085
Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 30/164 (18%)
Query: 146 KSSADKMQQ--------LNAAHQEALMKLERLDSVPVEEQEEFKQLS---DGIQELQQSL 194
+SS +K+Q L + +E++ + E++ S V+ + E Q+ + IQ L +S
Sbjct: 786 RSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSK 845
Query: 195 NQDFHQKTIVLQEGN---------SQKKSNISE-KTKRLNELKLSVVSLKEIQESLKTKI 244
Q+ ++ Q+ ++ S + E K K++NE+ V LKE SL
Sbjct: 846 EQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS 905
Query: 245 VDSP---------EKLKNYKEKMKDTVQKLKNARQEVVEKYEIY 279
+ E L+ +++++ + + K QEV+ Y ++
Sbjct: 906 YSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMH 949
Score = 35.4 bits (80), Expect = 0.11
Identities = 58/291 (19%), Positives = 119/291 (40%), Gaps = 51/291 (17%)
Query: 214 SNISEKTKRLNELKLSVVSLKEI-----QESLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268
S+I E RL++ SL +I Q+ L + + L + ++++D +Q
Sbjct: 317 SSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPK 376
Query: 269 RQEVVEKYEIY-------GDSV---------DCLPSCQLEVQLYQKKIQDLSDNREKLAS 312
E ++ Y G S+ D S + + K D ++L
Sbjct: 377 EAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQE 436
Query: 313 ILKESLNLEDQIESDESELKKLKTEENSFK-RLMIVKKEKLATAQFKINKKHEDVKQYKR 371
IL++ L+ ++ES E+E K+L+ E S + L+ + +++ +++K ++ +
Sbjct: 437 ILQD---LQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYE 493
Query: 372 TVIEDCNKVQE--KRGAV----------YERVTTINQEIQKIKLGIQQLKDAAEREKLKS 419
+++ VQ+ K G V + + +EI +K +Q + +ER K K
Sbjct: 494 EAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKV 553
Query: 420 QEIFLNL---------KTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFK 461
+E+ L K +E+Y + + SY + E + K +F+
Sbjct: 554 RELEEKLVEREKGTVIKPPVEEYEE-----MKSSYCSVIENMNKEKAFLFE 599
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 59.7 bits (143), Expect = 5e-09
Identities = 67/309 (21%), Positives = 147/309 (47%), Gaps = 34/309 (11%)
Query: 177 QEEFKQLSDGIQELQQSLNQDFHQ-KTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKE 235
QEE ++LS ++ L++ L Q+ K L+ + QK I +K++ LNE K+ + L+
Sbjct: 1651 QEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKA--IEDKSRSLNESKIEIERLQS 1708
Query: 236 IQESLKTKIVDSPEKLKNYKEKMKD--------------TVQKLKNARQ----EVVEKYE 277
+ E+L + + E+L+N + + D T+ +L++ Q +E
Sbjct: 1709 LTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQG 1768
Query: 278 IYGDSVDCLPSCQLEVQLYQKKIQDLS----DNREKLASILKESLNLEDQI---ESDESE 330
+ D + + E++ +QK+ + S +++ + +++E +L +I E D++
Sbjct: 1769 LINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKAR 1828
Query: 331 LKKLKTEENSFKRLMIVK---KEKLATAQFKI-NKKHEDVKQYKRTVIEDCNKVQEKRGA 386
L++L+ E N K + + K++L + +I N ++ QY R E K++ +R
Sbjct: 1829 LQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKE-EAIRKIESEREK 1887
Query: 387 VYERVTTINQEIQKIKLGIQQLKDAAERE-KLKSQEIFLNLKTALEKYHDGIEKAAEDSY 445
++ EI++++ I+++++ R+ + ++E L+T +Y I+K + Y
Sbjct: 1888 SEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPY 1947
Query: 446 AKIDEKTAE 454
E E
Sbjct: 1948 GSHRETQTE 1956
Score = 50.8 bits (120), Expect = 3e-06
Identities = 83/403 (20%), Positives = 165/403 (40%), Gaps = 92/403 (22%)
Query: 146 KSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQ----------SLN 195
+ +A Q L A + K + ++ + E QEE K+ + EL + SL
Sbjct: 1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLK 1363
Query: 196 QDF-----------HQKTIVLQEGNS----------QKKSNISEKTKRL-NELKLSVVSL 233
F HQ T+ +E S ++ ++SE+ KRL N L + +L
Sbjct: 1364 NQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENL 1423
Query: 234 KEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKY-EIYGDSVDCLPSCQLE 292
+ ++E ++ + E + K++++ ++++ R E +Y + D+ + E
Sbjct: 1424 RRVEEDIQQQKATGSE-VSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKE 1482
Query: 293 V----QLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMI-- 346
+ QL K+ D ++ A + + +L+ S + KLK +E RL I
Sbjct: 1483 IERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDY 1542
Query: 347 --VKKEK-------------LATAQFKINKKHEDVKQYKRTVIEDC---NKVQEK----R 384
V +E+ L Q + K E++ + KRT ED K++E+ R
Sbjct: 1543 ERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMR 1602
Query: 385 GAVYE---RVTTINQEIQKIKL-------GIQQLKDAAE---REKLKSQEIFLNLKTALE 431
++ E ++T + Q++++ + ++Q +D + REK ++QE L + +E
Sbjct: 1603 RSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVE 1662
Query: 432 KY-----------------HDGIEKAAEDSYAKIDEKTAELKR 457
++ +KA ED ++E E++R
Sbjct: 1663 ALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIER 1705
Score = 36.2 bits (82), Expect = 0.065
Identities = 58/324 (17%), Positives = 129/324 (39%), Gaps = 28/324 (8%)
Query: 146 KSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVL 205
KS+ + + +E K+ RL +E+ K + D + + +Q L
Sbjct: 1091 KSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQ--------L 1142
Query: 206 QEGNSQKKSNIS----EKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDT 261
Q+ +K N+ E K + E + + L+ + + T+ + +L + +
Sbjct: 1143 QKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEE 1202
Query: 262 VQKLKNARQEVVEKY-----EIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKE 316
+ L+N + + EI D + + ++ ++ +DL D +L + +
Sbjct: 1203 MSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQ 1262
Query: 317 SLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIED 376
+ + E + + K +E K+ + ++ +++ + + N +H+ + I+D
Sbjct: 1263 ATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQD 1322
Query: 377 CNKVQEKRGAVYE----RVTTINQEIQKIKLGIQQLKDAAEREKLKSQ-EIFLNL-KTAL 430
NK E+ A ++ R E+ K++ + E LK+Q E +N+ KT +
Sbjct: 1323 KNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDE-----EIISLKNQFETEINITKTTI 1377
Query: 431 EKYHDGIEKAAEDSYAKIDEKTAE 454
+ E+ A+ID T E
Sbjct: 1378 HQLTMQKEEDTSGYRAQIDNLTRE 1401
Score = 35.8 bits (81), Expect = 0.085
Identities = 51/253 (20%), Positives = 105/253 (41%), Gaps = 26/253 (10%)
Query: 197 DFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESL------------KTKI 244
D H + I L + +SE K L +LKL ++ ++E L K K
Sbjct: 998 DVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKF 1057
Query: 245 VDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSV-DCLPSCQLEVQLYQKKIQDL 303
+D + L+ Y+ + KL + +E+ + E+ G S L C +++ +KI L
Sbjct: 1058 LD--QNLQKYQAECSQFKAKLASL-EELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
Query: 304 SDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKH 363
+ E K + DQ ++D +L+K + E ++ EK I +K
Sbjct: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEK------AIKEKE 1168
Query: 364 EDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEI----QKIKLGIQQLKDAAEREKLKS 419
++++ + + E+ + +E + + N+E+ K + I K + ++
Sbjct: 1169 YEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQK 1228
Query: 420 QEIFLNLKTALEK 432
++ NL+ L++
Sbjct: 1229 EDDSKNLRNQLDR 1241
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 59.7 bits (143), Expect = 5e-09
Identities = 60/318 (18%), Positives = 150/318 (47%), Gaps = 28/318 (8%)
Query: 140 EFLWQYKSSADKMQQLNAAHQEALMKLERL--DSVPVEEQEEFKQLSDGIQELQQSLNQD 197
E +W+ + + +++ +E + +LE + + EQEE +Q + I+E Q Q+
Sbjct: 417 EMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE--QEKRQE 474
Query: 198 FHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKI----------VDS 247
K +E +++ I E+ +++ + + ++I+E K + +
Sbjct: 475 QEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE 534
Query: 248 PEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQD----L 303
E++ KEK+ + +K++ +++ + E D + + + +V ++KI++ +
Sbjct: 535 QEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKI 594
Query: 304 SDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKH 363
+ EK+ +E + E + + E E K + EE M ++EK+ + KI ++
Sbjct: 595 REQEEKIRE--QEEMTQEQEEKMGEQEEKMCEQEEK-----MQEQEEKMRRQEEKIREQE 647
Query: 364 EDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIF 423
+ +++ + + E +QE+ ++E+ + + Q+ K+ Q+ K + EK+ QE+
Sbjct: 648 KKIREQEEKIREQEEMMQEQEEKMWEQEEKMCE--QEEKMQEQEEKMRRQEEKMWEQEVR 705
Query: 424 L-NLKTALEKYHDGIEKA 440
L + ++++ + +E A
Sbjct: 706 LRQQEEKMQEHQEHLEAA 723
Score = 57.4 bits (137), Expect = 3e-08
Identities = 58/325 (17%), Positives = 147/325 (45%), Gaps = 47/325 (14%)
Query: 140 EFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFH 199
E +W+ + + +++ +E K+ R + + E++E+ ++L + + E
Sbjct: 403 EMMWEKEEKMRRQEEMMWEKEE---KMRRQEEMMWEKEEKIRELEEKMHE---------- 449
Query: 200 QKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMK 259
Q+ I QE Q++ I E+ KR + + K+ EK++ +EK++
Sbjct: 450 QEKIREQEEKRQEEEKIREQEKRQEQ---------------EAKMWRQEEKIREQEEKIR 494
Query: 260 DTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLN 319
+ +K+ +++ E+ +I + Q E+ ++KI++ + I ++
Sbjct: 495 EQEEKMWRQEEKIHEQEKIREEEKR---QEQEEMWRQEEKIREQEE-------IWRQKEK 544
Query: 320 LEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNK 379
+ +Q E + +K+ +E M ++EK+ + K+ ++ E +++ + + E K
Sbjct: 545 IHEQEEKIRKQEEKMWRQEEK----MHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEK 600
Query: 380 VQEKRGAVYERVTTINQEIQKI-----KLGIQQLKDAAEREKLKSQEIFLNLKTALEKYH 434
++E+ E+ + ++ +K+ K+ Q+ K + EK++ QE + + +
Sbjct: 601 IREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 660
Query: 435 DGIEKAAEDSYAKIDEKTAELKRKM 459
+ + + E+ + +EK E + KM
Sbjct: 661 EEMMQEQEEKMWEQEEKMCEQEEKM 685
Score = 55.8 bits (133), Expect = 8e-08
Identities = 59/318 (18%), Positives = 144/318 (45%), Gaps = 21/318 (6%)
Query: 153 QQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQK 212
QQL A EA + L SV + Q + ++ EL LNQ +K +E +
Sbjct: 322 QQLQA---EADHLGKELQSVSAKLQAQVEE-----NELWNRLNQQQEEKMWRQEEKIQEW 373
Query: 213 KSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEV 272
+ I E+ +++ E + + +E + + + EK++ +E M + +K++ + +
Sbjct: 374 EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM 433
Query: 273 VEKYEIYGDSVDCLPSC-----QLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESD 327
EK E + + + Q E + ++KI++ +E+ A + ++ + +Q E
Sbjct: 434 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 493
Query: 328 ESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQY------KRTVIEDCNKVQ 381
+ +K+ +E +++E+ Q ++ ++ E +++ K + E K++
Sbjct: 494 REQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIR 553
Query: 382 EKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDGIEKAA 441
++ ++ + ++ + +KI+ Q+ K + EK++ QE + + + + + +
Sbjct: 554 KQEEKMWRQEEKMHDQEEKIRE--QEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQ 611
Query: 442 EDSYAKIDEKTAELKRKM 459
E+ + +EK E + KM
Sbjct: 612 EEKMGEQEEKMCEQEEKM 629
Score = 53.9 bits (128), Expect = 3e-07
Identities = 72/338 (21%), Positives = 154/338 (45%), Gaps = 33/338 (9%)
Query: 142 LWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQEL-----QQSLNQ 196
L++ + +++++ NA QE KL+ ++S E Q K+L ++ QQ L
Sbjct: 270 LYRNTITDEELKEKNAKLQE---KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA 326
Query: 197 DFHQKTIVLQEGNSQKKSNISEKT--KRLNELKLSVVSLKE--IQESLKTKIVDSPEKLK 252
+ LQ +++ ++ + E RLN+ + + +E IQE + KI + EK++
Sbjct: 327 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE-WEEKIQEQEEKIR 385
Query: 253 NYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLAS 312
+EK+++ +K++ + + EK E + + + +++ ++ + + + +L
Sbjct: 386 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 445
Query: 313 ILKESLNLEDQIESDESELKKLKTEENSFKRL-MIVKKEKLATAQFKINKKHEDVKQYKR 371
+ E + +Q E + E K + E+ + M ++EK+ + KI ++ E + + +
Sbjct: 446 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEE 505
Query: 372 TVIEDCNKVQEKRGAVYERVTTINQEI--------QKIKLGIQQLKDAAEREKLKSQEIF 423
+ E +E++ E + ++I QK K+ Q+ K + EK+ QE
Sbjct: 506 KIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQE-- 563
Query: 424 LNLKTALEKYHDGIEK--AAEDSYAKIDEKTAELKRKM 459
EK HD EK E+ + +EK E + K+
Sbjct: 564 -------EKMHDQEEKIREQEEKVWRQEEKIREQEEKI 594
Score = 39.7 bits (91), Expect = 0.006
Identities = 29/158 (18%), Positives = 74/158 (46%), Gaps = 10/158 (6%)
Query: 128 IHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLE---RLDSVPVEEQEE-FKQL 183
IH +E E +W+ + ++ +E + + E R + EQEE ++
Sbjct: 545 IHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQ 604
Query: 184 SDGIQELQQSLNQ------DFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQ 237
+ QE ++ + + + +K +E +++ I E+ K++ E + + +E+
Sbjct: 605 EEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 664
Query: 238 ESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEK 275
+ + K+ + EK+ +EKM++ +K++ +++ E+
Sbjct: 665 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 702
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 59.7 bits (143), Expect = 5e-09
Identities = 74/334 (22%), Positives = 157/334 (47%), Gaps = 47/334 (14%)
Query: 152 MQQLNAAHQEALMKLER-LDSVPVEEQEEFKQLSDGIQELQQSLNQ-------DFHQKTI 203
++Q N A ++ L K+ + LD ++ + E IQ+L+Q L HQ
Sbjct: 2051 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110
Query: 204 VLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQ 263
V Q N ++ EKT + +EL LS +E L+ I + E+++ + ++++ Q
Sbjct: 2111 VEQLAN-----HLKEKTDKCSELLLS-------KEQLQRDIQERNEEIEKLEFRVRELEQ 2158
Query: 264 KLKNARQ--EVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLE 321
L + + VE + +G +V+ P LEVQL ++ D D +EK E NLE
Sbjct: 2159 ALLVSADTFQKVEDRKHFG-AVEAKPELSLEVQLQAER--DAIDRKEK------EITNLE 2209
Query: 322 DQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKH----EDVKQYKRTVIE-D 376
+Q+E EL+ E + ++K++ T ++ +++ +D+++ + E D
Sbjct: 2210 EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESD 2269
Query: 377 CNKVQEKR-------GAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQ-EIFLNLKT 428
Q++ + E+ I+Q +++ QQLK + + ++ + E+ +L+T
Sbjct: 2270 AMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLET 2329
Query: 429 ALE---KYHDGIEKAAEDSYAKIDEKTAELKRKM 459
+E + +++ E+ +++E +L++++
Sbjct: 2330 QIECLMSDQECVKRNREEEIEQLNEVIEKLQQEL 2363
Score = 57.0 bits (136), Expect = 4e-08
Identities = 80/320 (25%), Positives = 149/320 (46%), Gaps = 43/320 (13%)
Query: 154 QLNAAHQEALMKLERLDSVPVEEQEEFKQLSD--GIQELQQ--SLNQDFHQKTIVLQEGN 209
QL +H+E L KL+ + + +E + ++L D GI QQ L + QK +Q
Sbjct: 628 QLLFSHEEELSKLK--EDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF-- 683
Query: 210 SQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNAR 269
+K N+ K N+L L + LK++Q+SL K + ++ + ++++ R
Sbjct: 684 --EKDNLITKQ---NQLILEISKLKDLQQSLVNS------KSEEMTLQINELQKEIEILR 732
Query: 270 QEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDL-SDNREKLASILKESLNLEDQIESDE 328
QE EK G + QL+ +L +K++++ +D +EK A + E+ L+D+ ++ E
Sbjct: 733 QEEKEK----GTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE 788
Query: 329 SELKKLKTEENSFKRLM----IVKKEKLATAQFKIN---KKHEDVKQYKRTVIEDCNKVQ 381
LK + T + +RL+ I K K + + +I +++ED+KQ + E+ K +
Sbjct: 789 DMLK-IHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQR 847
Query: 382 EKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQ-EIFLNLKTALEKYHDGIEKA 440
+ QE+Q+ + ++KD E K K + E LK E+ H
Sbjct: 848 NTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELH------ 901
Query: 441 AEDSYAKIDEKTAELKRKMF 460
+I+ T ++K +F
Sbjct: 902 ----LQRINPTTVKMKSSVF 917
Score = 53.9 bits (128), Expect = 3e-07
Identities = 62/318 (19%), Positives = 143/318 (44%), Gaps = 45/318 (14%)
Query: 147 SSADKMQ--QLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQE------------LQQ 192
++AD +Q Q HQ+ L + + L +++E+F +QE ++
Sbjct: 259 TAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVEN 318
Query: 193 SLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLK 252
S ++ +K +++E N++ I E+ K+ ELK + + ++ L+ +IV +++K
Sbjct: 319 SNKEEIQEKETIIEELNTK----IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIK 374
Query: 253 NYKEKMKDTVQKLKNARQEV------VEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDN 306
N K ++ ++ QK + + +E+ VE+ + Q E + Q+ Q+
Sbjct: 375 NMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHK-----DSQFETDIVQRMEQETQRK 429
Query: 307 REKLASILKESLN------LEDQIESDESELKKLKTE-----ENSFKRL--MIVKKEKLA 353
E+L + L E ++ I ++++++KT EN+ + + V ++++
Sbjct: 430 LEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK 489
Query: 354 TAQFKINK---KHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKD 410
IN+ K +D K + E+ + E++ A+ ++ + +E+ + IQ+ +
Sbjct: 490 LMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ 549
Query: 411 AAEREKLKSQEIFLNLKT 428
++ K E +L T
Sbjct: 550 TIAEQESKLNEAHKSLST 567
Score = 48.9 bits (115), Expect = 1e-05
Identities = 64/315 (20%), Positives = 136/315 (43%), Gaps = 24/315 (7%)
Query: 132 EACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERL-------DSVPVEEQEE-FKQL 183
E ++ +M+ Q K S ++Q+L ++ +E+L D++ ++Q F +
Sbjct: 2224 EEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKF 2283
Query: 184 SDGIQELQQSLNQDFHQKTIVLQEGNSQKKSN-ISEKTKRLNELKLSVVSLKEIQESLKT 242
+ IQE + ++Q Q T + Q+ + I EK + + +L+ + L QE +K
Sbjct: 2284 AQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKR 2343
Query: 243 KIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQK---- 298
+ E+L EK++ Q+L N Q+ + D L QL+V + +K
Sbjct: 2344 NREEEIEQLNEVIEKLQ---QELANIGQKTSMNAHSLSEEADSLKH-QLDVVIAEKLALE 2399
Query: 299 -KIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQF 357
+++ ++ + ++LKE+ +Q+ EL LK E S +++ + + + A
Sbjct: 2400 QQVETANEEMTFMKNVLKETNFKMNQL---TQELFSLKRERESVEKIQSIPENSVNVA-- 2454
Query: 358 KINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKL 417
I+ +D + + + ED K E + I ++ + QL+ + L
Sbjct: 2455 -IDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDL 2513
Query: 418 KSQEIFLNLKTALEK 432
+ + + +K E+
Sbjct: 2514 ELTQCYKQIKDMQEQ 2528
Score = 46.6 bits (109), Expect = 5e-05
Identities = 58/286 (20%), Positives = 126/286 (44%), Gaps = 52/286 (18%)
Query: 213 KSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDT----VQKLKNA 268
+S ++ K + EL +E++E T + ++L+ ++ +K Q N
Sbjct: 161 ESELAGKQHEIEELN------RELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANL 214
Query: 269 RQEVVEKYEIYGDSVDCLPSCQ-LEVQLYQKKIQDL------SDNREKLASILKESLNLE 321
+Q EK E + ++ Q L++Q Q + + S L ++ L +
Sbjct: 215 QQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274
Query: 322 DQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVK----QYKRTVIEDC 377
Q+E + L+ + ++ F + +EK+ + + +KK E+ Q K T+IE+
Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334
Query: 378 NK--VQEKR----------------GAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKS 419
N ++E++ G + E++ NQEI+ +KL +L ++ ++E+ S
Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKL---ELTNSKQKERQSS 391
Query: 420 QEI--FLNLKTALEKYH--------DGIEKAAEDSYAKIDEKTAEL 455
+EI + L+K + D +++ +++ K+++ AEL
Sbjct: 392 EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
Score = 45.1 bits (105), Expect = 1e-04
Identities = 70/320 (21%), Positives = 149/320 (46%), Gaps = 39/320 (12%)
Query: 151 KMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNS 210
+M+++ H+ + R S +++ K ++ I EL I LQ+ NS
Sbjct: 459 QMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN-----------IKLQDTNS 507
Query: 211 QKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQ 270
QK+ + E+ + E K + L+ E L ++ S E+++ ++ + + KL A +
Sbjct: 508 QKEK-LKEELGLILEEKCA---LQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHK 563
Query: 271 EVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQI-ESDES 329
+ ++ + V S + +L K ++++ + KL + KE + D++ ES E+
Sbjct: 564 SLSTVEDLKAEIVSASESRK---ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA 620
Query: 330 ELKKLKTEENSFKRLMIVKKEKLATAQFKINKKH----EDVK-----QYKRTVIEDCNKV 380
EL++L+T+ L+ +E+L+ + + +H E +K YK+ + N++
Sbjct: 621 ELERLRTQ------LLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEM 674
Query: 381 QEKRGAV-YERVTTINQEIQKIKLGIQQLKDAAER-EKLKSQEIFLNLKTALEKYHDGIE 438
+K + +E+ I ++ Q I L I +LKD + KS+E+ L + ++ I
Sbjct: 675 SQKIETMQFEKDNLITKQNQLI-LEISKLKDLQQSLVNSKSEEMTLQINELQKEIE--IL 731
Query: 439 KAAEDSYAKIDEKTAELKRK 458
+ E ++++ EL+ K
Sbjct: 732 RQEEKEKGTLEQEVQELQLK 751
Score = 42.7 bits (99), Expect = 7e-04
Identities = 75/348 (21%), Positives = 148/348 (42%), Gaps = 65/348 (18%)
Query: 151 KMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNS 210
++Q+ +Q A+ L++ D + L IQ L +N +K + +E S
Sbjct: 3067 RIQEQGVEYQAAMECLQKADR---------RSLLSEIQALHAQMNG---RKITLKREQES 3114
Query: 211 QKKS------NISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQK 264
+K S NI +K ++ E+++ + S+K+ + + E+L + K + + +
Sbjct: 3115 EKPSQELLEYNIQQKQSQMLEMQVELSSMKD-------RATELQEQLSSEKMVVAELKSE 3167
Query: 265 LKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSD--------NREKLASILKE 316
L + E+ + + L + +LEV+ ++ L+D +RE ++ KE
Sbjct: 3168 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKE 3227
Query: 317 SLNLEDQIESDESELKKLKTEENSFKR-------LMIVKKEKLATAQFKINKK------- 362
L E D+ EL+ LK S K+ L+ +K+ L +Q KI +
Sbjct: 3228 KAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQ 3287
Query: 363 --HEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAE-REKLKS 419
E + + V+ + KV+ + E +T+++E +++ +Q + R L S
Sbjct: 3288 LSEEQGRNLELQVLLESEKVR-----IREMSSTLDRE-RELHAQLQSSDGTGQSRPPLPS 3341
Query: 420 QEIFLNLKTALEKYHDGI-EKAAEDSYAKID--------EKTAELKRK 458
+++ L+ LE+ H I E E K+D EK ++ RK
Sbjct: 3342 EDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRK 3389
Score = 40.8 bits (94), Expect = 0.003
Identities = 71/318 (22%), Positives = 146/318 (45%), Gaps = 43/318 (13%)
Query: 149 ADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEG 208
AD+ QE ++RL+ + ++L Q++Q+ QK + E
Sbjct: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
Query: 209 NSQKKSNISEKTKRLNELKLSVVSLKE-----IQESLKTKIVDSPEKLKNYKEKMKDTVQ 263
++ + E T++L + KL V E +Q+ +K +D E++ + E ++
Sbjct: 1988 GPVEQQLLQE-TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNT 2046
Query: 264 KLKNARQE------VVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKES 317
+L + RQ+ +EK + D + + E ++Q++IQ L + + S
Sbjct: 2047 ELMDLRQQNQALEKQLEKMRKFLD--EQAIDREHERDVFQQEIQKLEQQLKVVPRFQPIS 2104
Query: 318 LNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIE-- 375
+ ++E + LK+ KT++ S +++ KE+L Q I +++E++++ + V E
Sbjct: 2105 EHQTREVEQLANHLKE-KTDKCS---ELLLSKEQL---QRDIQERNEEIEKLEFRVRELE 2157
Query: 376 --------DCNKVQEKR--GAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLN 425
KV++++ GAV E ++ E+Q +Q +DA +R K +EI N
Sbjct: 2158 QALLVSADTFQKVEDRKHFGAV-EAKPELSLEVQ-----LQAERDAIDR---KEKEI-TN 2207
Query: 426 LKTALEKYHDGIEKAAED 443
L+ LE++ + +E E+
Sbjct: 2208 LEEQLEQFREELENKNEE 2225
Score = 33.9 bits (76), Expect = 0.32
Identities = 54/334 (16%), Positives = 144/334 (43%), Gaps = 30/334 (8%)
Query: 144 QYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQ----------- 192
Q +++ ++M + +E K+ +L +E K+ + ++++Q
Sbjct: 2401 QVETANEEMTFMKNVLKETNFKMNQL----TQELFSLKRERESVEKIQSIPENSVNVAID 2456
Query: 193 SLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLK----EIQESLKTKIVDSP 248
L++D + +VL E + N + K S+++L+ +++ ++ K ++
Sbjct: 2457 HLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELT 2516
Query: 249 EKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNR- 307
+ K K+ + + + ++++V +I + V Q++++ Q+ + DN+
Sbjct: 2517 QCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
Query: 308 ----EKLASILKESLNLEDQIESDESEL----KKLKTEENSFKRLMIVKKEKLATAQFKI 359
+ +I + ED++ SD S L +L+++ +I++KE++ A+ +
Sbjct: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
Query: 360 NKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKS 419
+K + + + ++ + + K +EK + + + ++ ++ E E L++
Sbjct: 2637 LEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRA 2696
Query: 420 QEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTA 453
+ + K L Y + EK E+ K T+
Sbjct: 2697 ESV--ATKAELASYKEKAEKLQEELLVKETNMTS 2728
Score = 30.8 bits (68), Expect = 2.7
Identities = 65/326 (19%), Positives = 140/326 (42%), Gaps = 44/326 (13%)
Query: 150 DKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEG- 208
D Q+L +QE E L + + E ++ + +QE + LN+ Q++ + E
Sbjct: 1589 DMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENL 1648
Query: 209 NSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268
S+++ + E+ + L +L L+ +E L ++ +S + +N E +
Sbjct: 1649 VSERERVLLEELEALKQLSLAG------REKLCCELRNSSTQTQNGNENQGE-------V 1695
Query: 269 RQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNR--EKLASILKESLNLEDQIES 326
++ ++ E+ D P E+ ++ ++NR + L ++K + +E+ I
Sbjct: 1696 EEQTFKEKELDRKPEDVPP----EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
Query: 327 DESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKH-----EDVKQYK-----RTVIED 376
+ ++ S L I + E A+ + ++++H E + Y R I
Sbjct: 1752 HVLGILDRSSKSQSSASL-IWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINM 1810
Query: 377 CNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDG 436
+KV E+ + +R+ ++ G + E E+L I L+ A+EK +
Sbjct: 1811 WSKVTEEGTELSQRL---------VRSGFAGTEIDPENEEL-MLNISSRLQAAVEKLLEA 1860
Query: 437 I-EKAAEDSYAKIDEKTAELKRKMFK 461
I E +++ +AK+ + EL R+ F+
Sbjct: 1861 ISETSSQLEHAKVTQ--TELMRESFR 1884
Score = 30.4 bits (67), Expect = 3.6
Identities = 47/254 (18%), Positives = 112/254 (44%), Gaps = 35/254 (13%)
Query: 175 EEQEEFKQLSDGIQELQQSLNQ---DFHQKTIVLQEGNSQKKSN---ISEKTKRLNELKL 228
E QEE+ L +L+ S N+ ++ K L E ++ N + K+ +E K
Sbjct: 863 ELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKT 922
Query: 229 SVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPS 288
V E+ E ++ + EKL+ K + + Q+L + +++ +K+
Sbjct: 923 FVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG----------- 971
Query: 289 CQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESE-LKKLKTEENSFKRLMIV 347
E+ ++++ L +E+++ +E LE I + +E ++ T+ +S ++
Sbjct: 972 ---EISFLNEEVKSLKQEKEQVSLRCRE---LEIIINHNRAENVQSCDTQVSSLLDGVVT 1025
Query: 348 KKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQ 407
+ A+ ++K ++ + + ++ED KV +E + T+ +E ++ +L +
Sbjct: 1026 MTSR--GAEGSVSKVNKSFGEESKIMVED--KVS------FENM-TVGEESKQEQLILDH 1074
Query: 408 LKDAAEREKLKSQE 421
L + L++ +
Sbjct: 1075 LPSVTKESSLRATQ 1088
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 59.3 bits (142), Expect = 7e-09
Identities = 74/355 (20%), Positives = 148/355 (41%), Gaps = 42/355 (11%)
Query: 146 KSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQ--------- 196
KS +K+ + A ++E+ + +E K+ +D I L+QSL +
Sbjct: 141 KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQV 200
Query: 197 -DFHQKTIVLQEGNSQKKSNISEKTKRLN----ELKLSVVSLKEIQESLKTKIVDSPEKL 251
D + K +L++ + E + LN LK + ++ +E L+ K + L
Sbjct: 201 EDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL 260
Query: 252 KNYKEKMKDTVQKLKNARQEVVEKYEIYGD----SVDCLPSCQLEVQLYQKKIQDLSDNR 307
+ KE QKL + ++E+V++ ++ + ++D L Q + + ++ ++ L +
Sbjct: 261 QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEA 320
Query: 308 EKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVK 367
+ A LK LE++++ E+EL+K L+ K + + + + + E K
Sbjct: 321 KSRAEELKL---LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK 377
Query: 368 QYKRTVIEDC----NKVQEKRGAVYERVTTINQEIQKIKLG----IQQLKDAAEREKLKS 419
+ IED + +QEK + + +I + ++ L D + LK
Sbjct: 378 ALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKE 437
Query: 420 QEI----------FLNLKTALEKYHDGIEKAAEDSYAKIDEK---TAELKRKMFK 461
EI +L+ L++ + K ED + EK TAEL ++ K
Sbjct: 438 TEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK 492
Score = 53.9 bits (128), Expect = 3e-07
Identities = 70/283 (24%), Positives = 128/283 (45%), Gaps = 29/283 (10%)
Query: 187 IQELQQSLNQDFHQKTIVLQEGN--SQKKSNISEK--TKRLNELKLSVVSLKEIQESLKT 242
+Q Q+SL + Q I EG S +K I EK T++L E + + E K
Sbjct: 109 LQVTQRSLEES--QGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 166
Query: 243 KIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQD 302
I E LK + D + LK Q + E I V+ L ++ QL +K+ +D
Sbjct: 167 DIAQLEENLK----EKNDEILSLK---QSLEENIVILSKQVEDL---NVKCQLLEKEKED 216
Query: 303 -LSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKE-------KLAT 354
++ NRE ++ E NL+ + ++ E +KL+ +E L+ +KE KL +
Sbjct: 217 HVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCS 276
Query: 355 AQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQE----IQKIKLGIQQLKD 410
Q ++ K+ ++ + +++ +K+Q+K V + +E +++KL ++LK
Sbjct: 277 FQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLK- 335
Query: 411 AAEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTA 453
E E KS L++ +D + ++ ED A+ + A
Sbjct: 336 GKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKA 378
Score = 35.0 bits (79), Expect = 0.14
Identities = 64/316 (20%), Positives = 130/316 (41%), Gaps = 58/316 (18%)
Query: 146 KSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVL 205
K ++++ +AAH +A + L+ V+ E+ + + L S +D + L
Sbjct: 335 KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL 394
Query: 206 QEGNSQ--------------KKSNISEKTKRLNELK----LSVVSLKEIQESLKTKIVDS 247
QE ++ +S+ E + L +L+ L +KEI S KI D
Sbjct: 395 QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL 454
Query: 248 PEKLKNYKEKMKDTVQ-------KLKNARQEVVEKYE----IYGDSVDCLPSCQLEVQLY 296
+LK +E + ++ + +N E+ E+ +Y + + QL++ +
Sbjct: 455 QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF 514
Query: 297 QKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQ 356
+ + Q ++L E ++Q+ KL +N +++ V K K +Q
Sbjct: 515 EVEKQ----------ALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQ 564
Query: 357 FKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREK 416
K +V + + C ++K+ T + +E+ K+ LGI+ D ++
Sbjct: 565 LK-----SEVSKLR------CQLAKKKQSE-----TKLQEELNKV-LGIKHF-DPSKAFH 606
Query: 417 LKSQEIFLNLKTALEK 432
+S+E F LKT L++
Sbjct: 607 HESKENFA-LKTPLKE 621
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,101,461
Number of Sequences: 37866
Number of extensions: 653347
Number of successful extensions: 7473
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 170
Number of HSP's successfully gapped in prelim test: 777
Number of HSP's that attempted gapping in prelim test: 4141
Number of HSP's gapped (non-prelim): 2627
length of query: 464
length of database: 18,247,518
effective HSP length: 106
effective length of query: 358
effective length of database: 14,233,722
effective search space: 5095672476
effective search space used: 5095672476
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.