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Search of human proteins with 108773782
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|108773782 ATP-binding cassette, sub-family E, member 1 [Homo
sapiens]
(599 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|108773784 ATP-binding cassette, sub-family E, member 1 [Homo ... 1202 0.0
gi|108773782 ATP-binding cassette, sub-family E, member 1 [Homo ... 1202 0.0
gi|148612853 ATP-binding cassette, sub-family F (GCN20), member ... 66 8e-11
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 63 9e-10
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 60 6e-09
gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo s... 57 6e-08
gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo sa... 57 6e-08
gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sap... 57 6e-08
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 55 1e-07
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 55 2e-07
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 55 2e-07
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 54 4e-07
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 54 4e-07
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 52 2e-06
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6... 52 2e-06
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5... 52 2e-06
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3... 52 2e-06
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4... 52 2e-06
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2... 52 2e-06
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 52 2e-06
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 52 2e-06
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 52 2e-06
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 52 2e-06
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 50 5e-06
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 50 5e-06
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 49 1e-05
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 49 1e-05
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 49 1e-05
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 49 1e-05
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 49 2e-05
>gi|108773784 ATP-binding cassette, sub-family E, member 1 [Homo
sapiens]
Length = 599
Score = 1202 bits (3110), Expect = 0.0
Identities = 599/599 (100%), Positives = 599/599 (100%)
Query: 1 MADKLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQSKIAWISETLCIGCGI 60
MADKLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQSKIAWISETLCIGCGI
Sbjct: 1 MADKLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQSKIAWISETLCIGCGI 60
Query: 61 CIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRPGEVLGLVGTNGIGKSTAL 120
CIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRPGEVLGLVGTNGIGKSTAL
Sbjct: 61 CIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRPGEVLGLVGTNGIGKSTAL 120
Query: 121 KILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILEDDLKAIIKPQYVDQIPKAA 180
KILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILEDDLKAIIKPQYVDQIPKAA
Sbjct: 121 KILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILEDDLKAIIKPQYVDQIPKAA 180
Query: 181 KGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMF 240
KGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMF
Sbjct: 181 KGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMF 240
Query: 241 DEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVT 300
DEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVT
Sbjct: 241 DEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVT 300
Query: 301 MPFSVREGINIFLDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEF 360
MPFSVREGINIFLDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEF
Sbjct: 301 MPFSVREGINIFLDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEF 360
Query: 361 ELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKS 420
ELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKS
Sbjct: 361 ELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKS 420
Query: 421 TGSVRQLLHEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALCLGKPA 480
TGSVRQLLHEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALCLGKPA
Sbjct: 421 TGSVRQLLHEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALCLGKPA 480
Query: 481 DVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIVFDGVPS 540
DVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIVFDGVPS
Sbjct: 481 DVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIVFDGVPS 540
Query: 541 KNTVANSPQTLLAGMNKFLSQLEITFRRDPNNYRPRINKLNSIKDVEQKKSGNYFFLDD 599
KNTVANSPQTLLAGMNKFLSQLEITFRRDPNNYRPRINKLNSIKDVEQKKSGNYFFLDD
Sbjct: 541 KNTVANSPQTLLAGMNKFLSQLEITFRRDPNNYRPRINKLNSIKDVEQKKSGNYFFLDD 599
>gi|108773782 ATP-binding cassette, sub-family E, member 1 [Homo
sapiens]
Length = 599
Score = 1202 bits (3110), Expect = 0.0
Identities = 599/599 (100%), Positives = 599/599 (100%)
Query: 1 MADKLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQSKIAWISETLCIGCGI 60
MADKLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQSKIAWISETLCIGCGI
Sbjct: 1 MADKLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQSKIAWISETLCIGCGI 60
Query: 61 CIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRPGEVLGLVGTNGIGKSTAL 120
CIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRPGEVLGLVGTNGIGKSTAL
Sbjct: 61 CIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRPGEVLGLVGTNGIGKSTAL 120
Query: 121 KILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILEDDLKAIIKPQYVDQIPKAA 180
KILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILEDDLKAIIKPQYVDQIPKAA
Sbjct: 121 KILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILEDDLKAIIKPQYVDQIPKAA 180
Query: 181 KGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMF 240
KGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMF
Sbjct: 181 KGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMF 240
Query: 241 DEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVT 300
DEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVT
Sbjct: 241 DEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVT 300
Query: 301 MPFSVREGINIFLDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEF 360
MPFSVREGINIFLDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEF
Sbjct: 301 MPFSVREGINIFLDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEF 360
Query: 361 ELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKS 420
ELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKS
Sbjct: 361 ELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKS 420
Query: 421 TGSVRQLLHEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALCLGKPA 480
TGSVRQLLHEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALCLGKPA
Sbjct: 421 TGSVRQLLHEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALCLGKPA 480
Query: 481 DVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIVFDGVPS 540
DVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIVFDGVPS
Sbjct: 481 DVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIVFDGVPS 540
Query: 541 KNTVANSPQTLLAGMNKFLSQLEITFRRDPNNYRPRINKLNSIKDVEQKKSGNYFFLDD 599
KNTVANSPQTLLAGMNKFLSQLEITFRRDPNNYRPRINKLNSIKDVEQKKSGNYFFLDD
Sbjct: 541 KNTVANSPQTLLAGMNKFLSQLEITFRRDPNNYRPRINKLNSIKDVEQKKSGNYFFLDD 599
>gi|148612853 ATP-binding cassette, sub-family F (GCN20), member 3
[Homo sapiens]
Length = 709
Score = 66.2 bits (160), Expect = 8e-11
Identities = 119/537 (22%), Positives = 212/537 (39%), Gaps = 103/537 (19%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGK-------------QKPNLGKYDDPPDWQEILTYFRG 149
G GLVG NG+GK+T LK+LA + ++ G DD P Q +L
Sbjct: 203 GRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAG--DDTPALQSVLE--SD 258
Query: 150 SELQNYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQA---IVCQQLDL 206
S ++ + E +L A I + A + + L+ + K A ++ L
Sbjct: 259 SVREDLLRR--ERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGF 316
Query: 207 T-HLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINP 265
T ++++ + SGG R A A + D+ + DEP++ LDV +A + + + +
Sbjct: 317 TPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDV----RAILWLENYLQT 372
Query: 266 -DRYIIVVEHDLSVLDYLSDFICCLYG--------------------VPSAYGVVTMPFS 304
I+VV HD + L+ ++ I L+ + +
Sbjct: 373 WPSTILVVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERLLNQQREYEAQQQ 432
Query: 305 VREGINIFLDGYVPTENLRFRDAS---LVFKVAETANEEEVKKMCMYKYPGMKKKMGEFE 361
R+ I +F+D + N + S ++ K+ E ++ ++ M K+P +K
Sbjct: 433 YRQHIQVFIDRFRYNANRASQVQSKLKMLEKLPELKPVDKESEVVM-KFPDGFEKFSPPI 491
Query: 362 LAIVAGEF---------------TDSEIMV-MLGENGTGKTTFIRMLAGRLKPDEGGEVP 405
L + +F D E + ++GENG GK+T +++L G L P G
Sbjct: 492 LQLDEVDFYYDPKHVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRG---- 547
Query: 406 VLNVSYKPQKISPKSTGSVRQ---------LLHEKI----RDAYTHPQFVTDVMKPLQIE 452
+ +++ KI S V Q LL K + Y H + L +
Sbjct: 548 -IRHAHRNLKIGYFSQHHVEQLDLNVSAVELLARKFPGRPEEEYRHQLGRYGISGELAM- 605
Query: 453 NIIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILHAK 512
+ + +LSGG+ RVA A + Y++DEP+ +LD E R + F +
Sbjct: 606 ----RPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNF----R 657
Query: 513 KTAFVVEHDFIMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLEITFRRD 569
+V HD + + V +G + G +++ + L+ FRR+
Sbjct: 658 GGVILVSHDERFIRLVCRELWVCEG--------GGVTRVEGGFDQYRALLQEQFRRE 706
>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
Length = 1624
Score = 62.8 bits (151), Expect = 9e-10
Identities = 56/205 (27%), Positives = 99/205 (48%), Gaps = 20/205 (9%)
Query: 343 KKMCMYKYPGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPD--- 399
KK C K KKK+ ++ + E++ +LG NG GK+T I+M+ G KP
Sbjct: 1296 KKNCFSK---RKKKIATRNVSFCVKK---GEVIGLLGHNGAGKSTTIKMITGDTKPTAGQ 1349
Query: 400 -----EGGEVPVLNVSYKPQKISPKSTGSVRQLL--HEKIRDAYTHPQFV--TDVMKPLQ 450
GG P+ + Y PQ+ + +VRQ L + ++ + T ++ L+
Sbjct: 1350 VILKGSGGGEPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALK 1409
Query: 451 IENIIDQEVQTLSGGELQRVALALC-LGKPADVYLIDEPSAYLDSEQRLMAARVVKRFIL 509
+++ + V+TLS G +++ L LG P+ V L+DEPS +D E + +V++
Sbjct: 1410 LQDQLKAPVKTLSEGIKRKLCFVLSILGNPS-VVLLDEPSTGMDPEGQQQMWQVIRATFR 1468
Query: 510 HAKKTAFVVEHDFIMATYLADRVIV 534
+ ++ A + H A + DRV +
Sbjct: 1469 NTERGALLTTHYMAEAEAVCDRVAI 1493
Score = 58.2 bits (139), Expect = 2e-08
Identities = 80/304 (26%), Positives = 126/304 (41%), Gaps = 51/304 (16%)
Query: 268 YIIVVEHDLSVLDYLSDFICCLYG---VPSAYGVVTMPFSVREGINIFLDGYV------- 317
Y+I+ + V D L + LY +P+ YG P + F G
Sbjct: 397 YLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLEN 456
Query: 318 -----PTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEFELAIVAGEFTDS 372
PT N F S F E + +KK +Y G +++ L V + +
Sbjct: 457 ETDSDPTPNDCFEPVSPEFCGKEAIRIKNLKK----EYAGKCERVEA--LKGVVFDIYEG 510
Query: 373 EIMVMLGENGTGKTTFIRMLAGRLKPDEGGEV----------PVLNVS----YKPQKISP 418
+I +LG +G GKTT + +L+G P G + N+S + PQ
Sbjct: 511 QITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQ 570
Query: 419 KSTGSVRQLLH--EKIRDAYTHP--QFVTDVMKPLQIENIIDQEVQTLSGGELQRVALAL 474
+V++ L KI+ H + V V++ L++ENI D Q LSGG+ +++ +
Sbjct: 571 FGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGI 630
Query: 475 CLGKPADVYLIDEPSAYLDSEQRLMAARVVK-----RFILHAKKTAFVVEHDFIMATYLA 529
+ V L+DEP+A LD R ++K R IL + T F+ E D LA
Sbjct: 631 AILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFS--TQFIDEADI-----LA 683
Query: 530 DRVI 533
DR +
Sbjct: 684 DRKV 687
Score = 46.6 bits (109), Expect = 7e-05
Identities = 42/182 (23%), Positives = 81/182 (44%), Gaps = 7/182 (3%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILED 162
G++ L+G +G GK+T L IL+G P G + L+ E + FT
Sbjct: 510 GQITALLGHSGAGKTTLLNILSGLSVPTSGSVTV---YNHTLSRMADIENISKFTGFCPQ 566
Query: 163 DLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSGGEL 222
+ + AK + IL + E + Q +V Q+L++ ++++ ++LSGG+
Sbjct: 567 SNVQFGFLTVKENLRLFAK--IKGILPHEVEKEVQRVV-QELEMENIQDILAQNLSGGQN 623
Query: 223 QRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYL 282
++ + + + + DEP++ LD R + ++ DR I+ + D L
Sbjct: 624 RKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKE-GKSDRVILFSTQFIDEADIL 682
Query: 283 SD 284
+D
Sbjct: 683 AD 684
Score = 45.8 bits (107), Expect = 1e-04
Identities = 45/191 (23%), Positives = 84/191 (43%), Gaps = 15/191 (7%)
Query: 101 RPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKIL 160
+ GEV+GL+G NG GKST +K++ G KP G Q IL G E +
Sbjct: 1317 KKGEVIGLLGHNGAGKSTTIKMITGDTKPTAG--------QVILKGSGGGEPLGFLGYCP 1368
Query: 161 EDD-LKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSG 219
+++ L + + ++ A KG L + D + L L + V+ LS
Sbjct: 1369 QENALWPNLTVRQHLEVYAAVKG-----LRKGDAMIAITRLVDALKLQDQLKAPVKTLSE 1423
Query: 220 GELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLI-NPDRYIIVVEHDLSV 278
G ++ + + + + DEPS+ +D + + + IR+ N +R ++ H ++
Sbjct: 1424 GIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAE 1483
Query: 279 LDYLSDFICCL 289
+ + D + +
Sbjct: 1484 AEAVCDRVAIM 1494
>gi|90421313 cystic fibrosis transmembrane conductance regulator
[Homo sapiens]
Length = 1480
Score = 60.1 bits (144), Expect = 6e-09
Identities = 47/156 (30%), Positives = 79/156 (50%), Gaps = 14/156 (8%)
Query: 373 EIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKSTGSVRQLL---- 428
+++ + G G GKT+ + ++ G L+P EG +S+ Q S G++++ +
Sbjct: 452 QLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQ-FSWIMPGTIKENIIFGV 510
Query: 429 ---HEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQ-TLSGGELQRVALALCLGKPADVYL 484
+ R Q D+ K + +NI+ E TLSGG+ R++LA + K AD+YL
Sbjct: 511 SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYL 570
Query: 485 IDEPSAYLD--SEQRLMAARVVKRFILHAKKTAFVV 518
+D P YLD +E+ + + V K L A KT +V
Sbjct: 571 LDSPFGYLDVLTEKEIFESCVCK---LMANKTRILV 603
Score = 39.7 bits (91), Expect = 0.008
Identities = 46/193 (23%), Positives = 85/193 (44%), Gaps = 39/193 (20%)
Query: 92 FKLHRLPIPRPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPD---WQEILTYFR 148
FK+ R G++L + G+ G GK++ L ++ G+ +P+ GK +
Sbjct: 446 FKIER------GQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 149 GSELQNYFTKILEDDLK--AIIKP-QYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLD 205
G+ +N + D+ + ++IK Q + I K A+ KD IV +
Sbjct: 500 GTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAE---------KDN-----IVLGEGG 545
Query: 206 LTHLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDV--KQRLKAAITIRSLI 263
+T LSGG+ R + A + AD+++ D P YLDV ++ + + + +
Sbjct: 546 IT---------LSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMA 596
Query: 264 NPDRYIIV--VEH 274
N R ++ +EH
Sbjct: 597 NKTRILVTSKMEH 609
Score = 35.0 bits (79), Expect = 0.20
Identities = 42/165 (25%), Positives = 69/165 (41%), Gaps = 25/165 (15%)
Query: 377 MLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISP--KSTGSVRQLLH----- 429
+LG G+GK+T + L + GE+ + VS+ + K+ G + Q +
Sbjct: 1242 LLGRTGSGKSTLLSAFLRLLNTE--GEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGT 1299
Query: 430 -EKIRDAYTH--PQFVTDVMKPLQIENIIDQEVQ-----------TLSGGELQRVALALC 475
K D Y Q + V + + ++I+Q LS G Q + LA
Sbjct: 1300 FRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARS 1359
Query: 476 LGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEH 520
+ A + L+DEPSA+LD + R +K+ A T + EH
Sbjct: 1360 VLSKAKILLLDEPSAHLDPVTYQIIRRTLKQ--AFADCTVILCEH 1402
Score = 34.3 bits (77), Expect = 0.34
Identities = 53/200 (26%), Positives = 78/200 (39%), Gaps = 36/200 (18%)
Query: 102 PGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEI-LTYFR---GSELQNYFT 157
PG+ +GL+G G GKST L D W I L +R G Q F
Sbjct: 1236 PGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVF- 1294
Query: 158 KILEDDLKAIIKP--QYVDQIPKAAKGTVGSILDRKDETKTQAIVCQ---QLDLTHLKER 212
I + + P Q+ DQ I DE ++++ Q +LD +
Sbjct: 1295 -IFSGTFRKNLDPYEQWSDQ----------EIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 213 NVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLD------VKQRLKAAITIRSLINPD 266
V LS G Q A + KA I + DEPS++LD +++ LK A D
Sbjct: 1344 CV--LSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFA-------D 1394
Query: 267 RYIIVVEHDLSVLDYLSDFI 286
+I+ EH + + F+
Sbjct: 1395 CTVILCEHRIEAMLECQQFL 1414
>gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo
sapiens]
Length = 646
Score = 56.6 bits (135), Expect = 6e-08
Identities = 49/179 (27%), Positives = 80/179 (44%), Gaps = 18/179 (10%)
Query: 104 EVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTK---IL 160
E++G++G +G GKST + ILAG ++ + +IL R EL+ + I+
Sbjct: 96 ELIGIMGPSGAGKSTFMNILAGYRESGMKG--------QILVNGRPRELRTFRKMSCYIM 147
Query: 161 EDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAI--VCQQLDLTHLKERNVEDLS 218
+DD+ + P + +A + L K E K + + + L L LS
Sbjct: 148 QDDM---LLPHLT--VLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLS 202
Query: 219 GGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLS 277
GG+ +R A A+ + + FDEP+S LD + ++SL R II H S
Sbjct: 203 GGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPS 261
Score = 50.8 bits (120), Expect = 3e-06
Identities = 42/172 (24%), Positives = 81/172 (47%), Gaps = 18/172 (10%)
Query: 351 PGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVS 410
P +K+ + L ++G+F E++ ++G +G GK+TF+ +LAG + G++ ++N
Sbjct: 74 PCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQI-LVNGR 132
Query: 411 YKPQKISPKSTGSVRQ----LLHEKIRDAY-------------THPQFVTDVMKPLQIEN 453
+ + K + + Q L H + +A + VT+++ L + +
Sbjct: 133 PRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMS 192
Query: 454 IIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVK 505
LSGG+ +R+A+AL L V DEP++ LDS ++K
Sbjct: 193 CSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 244
>gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo
sapiens]
Length = 646
Score = 56.6 bits (135), Expect = 6e-08
Identities = 49/179 (27%), Positives = 80/179 (44%), Gaps = 18/179 (10%)
Query: 104 EVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTK---IL 160
E++G++G +G GKST + ILAG ++ + +IL R EL+ + I+
Sbjct: 96 ELIGIMGPSGAGKSTFMNILAGYRESGMKG--------QILVNGRPRELRTFRKMSCYIM 147
Query: 161 EDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAI--VCQQLDLTHLKERNVEDLS 218
+DD+ + P + +A + L K E K + + + L L LS
Sbjct: 148 QDDM---LLPHLT--VLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLS 202
Query: 219 GGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLS 277
GG+ +R A A+ + + FDEP+S LD + ++SL R II H S
Sbjct: 203 GGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPS 261
Score = 50.8 bits (120), Expect = 3e-06
Identities = 42/172 (24%), Positives = 81/172 (47%), Gaps = 18/172 (10%)
Query: 351 PGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVS 410
P +K+ + L ++G+F E++ ++G +G GK+TF+ +LAG + G++ ++N
Sbjct: 74 PCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQI-LVNGR 132
Query: 411 YKPQKISPKSTGSVRQ----LLHEKIRDAY-------------THPQFVTDVMKPLQIEN 453
+ + K + + Q L H + +A + VT+++ L + +
Sbjct: 133 PRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMS 192
Query: 454 IIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVK 505
LSGG+ +R+A+AL L V DEP++ LDS ++K
Sbjct: 193 CSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 244
>gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sapiens]
Length = 1581
Score = 56.6 bits (135), Expect = 6e-08
Identities = 47/176 (26%), Positives = 86/176 (48%), Gaps = 16/176 (9%)
Query: 373 EIMVMLGENGTGKTTFIRMLAGRLKPD--------EGGEVPVLNVSYKPQKISPKSTGSV 424
E++ +LG NG GK+T I+++ G KP GG + + Y PQ+ + +V
Sbjct: 1277 EVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEFLGYCPQENALWPNLTV 1336
Query: 425 RQLLH-----EKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALC-LGK 478
RQ L + +R +T ++ L++++ + V+TLS G +++ L LG
Sbjct: 1337 RQHLEVYAAVKGLRKGDAEVA-ITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGN 1395
Query: 479 PADVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIV 534
P+ V L+DEPS +D E + + ++ + ++ A + H A + DRV +
Sbjct: 1396 PS-VVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAI 1450
Score = 48.1 bits (113), Expect = 2e-05
Identities = 46/191 (24%), Positives = 84/191 (43%), Gaps = 15/191 (7%)
Query: 101 RPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKI- 159
R GEVLGL+G NG GKST++K++ G KP G Q +L G + +
Sbjct: 1274 RKGEVLGLLGHNGAGKSTSIKVITGDTKPTAG--------QVLLKGSGGGDALEFLGYCP 1325
Query: 160 LEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSG 219
E+ L + + ++ A KG L + D + L L + V+ LS
Sbjct: 1326 QENALWPNLTVRQHLEVYAAVKG-----LRKGDAEVAITRLVDALKLQDQLKSPVKTLSE 1380
Query: 220 GELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLI-NPDRYIIVVEHDLSV 278
G ++ + + + + DEPS+ +D + + + IR+ N +R ++ H ++
Sbjct: 1381 GIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAE 1440
Query: 279 LDYLSDFICCL 289
+ + D + +
Sbjct: 1441 AEAVCDRVAIM 1451
Score = 30.8 bits (68), Expect = 3.7
Identities = 13/30 (43%), Positives = 19/30 (63%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLG 132
G++ ++G +G GKST L IL+G P G
Sbjct: 509 GQITAILGHSGAGKSTLLNILSGLSVPTKG 538
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 55.5 bits (132), Expect = 1e-07
Identities = 52/203 (25%), Positives = 94/203 (46%), Gaps = 18/203 (8%)
Query: 343 KKMCMYKYPGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEG- 401
KK C K KKK+ ++ E EI+ +LG NG GK++ IRM++G KP G
Sbjct: 1290 KKSCFSK---RKKKIAARNISFCVQE---GEILGLLGPNGAGKSSSIRMISGITKPTAGE 1343
Query: 402 ----GEVPVL-NVSYKPQKISPKSTGSVRQLLH-----EKIRDAYTHPQFVTDVMKPLQI 451
G VL ++ Y PQ+ ++R+ L + +R A + ++ ++
Sbjct: 1344 VELKGCSSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLA-IARLVSAFKL 1402
Query: 452 ENIIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILHA 511
++ VQ L+ G +++ L L + V L+DEPS +D + + ++ + +
Sbjct: 1403 HEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNT 1462
Query: 512 KKTAFVVEHDFIMATYLADRVIV 534
++ + H+ A L DRV +
Sbjct: 1463 ERGVLLTTHNLAEAEALCDRVAI 1485
Score = 47.4 bits (111), Expect = 4e-05
Identities = 41/188 (21%), Positives = 88/188 (46%), Gaps = 15/188 (7%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILED 162
GE+LGL+G NG GKS+++++++G KP G+ + +L + +N +L
Sbjct: 1313 GEILGLLGPNGAGKSSSIRMISGITKPTAGEV-ELKGCSSVLGHLGYCPQENVLWPML-- 1369
Query: 163 DLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSGGEL 222
L+ + ++ A KG L + D A + L V+ L+ G
Sbjct: 1370 TLREHL------EVYAAVKG-----LRKADARLAIARLVSAFKLHEQLNVPVQKLTAGIT 1418
Query: 223 QRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLI-NPDRYIIVVEHDLSVLDY 281
++ + + + + + DEPS+ +D + + I++++ N +R +++ H+L+ +
Sbjct: 1419 RKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEA 1478
Query: 282 LSDFICCL 289
L D + +
Sbjct: 1479 LCDRVAIM 1486
Score = 40.4 bits (93), Expect = 0.005
Identities = 50/205 (24%), Positives = 87/205 (42%), Gaps = 29/205 (14%)
Query: 313 LDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEFE-LAIVAGEFTD 371
+D P+++ F + F+ E VKK +Y G K G+ E L + + +
Sbjct: 455 IDAEHPSDDY-FEPVAPEFQGKEAIRIRNVKK----EYKG---KSGKVEALKGLLFDIYE 506
Query: 372 SEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISP---KSTGSVRQL- 427
+I +LG +G GK++ + +L G P EG V + N + + K TG Q
Sbjct: 507 GQITAILGHSGAGKSSLLNILNGLSVPTEGS-VTIYNKNLSEMQDLEEIRKITGVCPQFN 565
Query: 428 -------------LHEKIRDAYTHP--QFVTDVMKPLQIENIIDQEVQTLSGGELQRVAL 472
L KI+ + Q V ++ L ++NI D + LS G+ +++
Sbjct: 566 VQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTF 625
Query: 473 ALCLGKPADVYLIDEPSAYLDSEQR 497
+ + + L+DEP+ LD R
Sbjct: 626 GITILGDPQILLLDEPTTGLDPFSR 650
Score = 38.5 bits (88), Expect = 0.018
Identities = 44/191 (23%), Positives = 83/191 (43%), Gaps = 25/191 (13%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRG-SELQNYFTKILE 161
G++ ++G +G GKS+ L IL G P G + Y + SE+Q+ LE
Sbjct: 507 GQITAILGHSGAGKSSLLNILNGLSVPTEGS---------VTIYNKNLSEMQD-----LE 552
Query: 162 DDLKAI-IKPQYVDQIP-------KAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERN 213
+ K + PQ+ Q + + I ++ E + Q I+ + LD+ ++++
Sbjct: 553 EIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLE-LDMQNIQDNL 611
Query: 214 VEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVE 273
+ LS G+ ++ + + I + DEP++ LD R + +R D I+
Sbjct: 612 AKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRER-RADHVILFST 670
Query: 274 HDLSVLDYLSD 284
+ D L+D
Sbjct: 671 QSMDEADILAD 681
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 55.1 bits (131), Expect = 2e-07
Identities = 57/251 (22%), Positives = 99/251 (39%), Gaps = 30/251 (11%)
Query: 78 NLEKETTHRYCANAFKLHRLPIP-RPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDD 136
NL K R + RL + RPGE GL+G NG GK++ K+L G + G+
Sbjct: 2055 NLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGE--- 2111
Query: 137 PPDWQEILTYFRGSELQNYFTKILE--------DDLKAIIKPQYVDQIPKAAKGTVGSIL 188
+ G + ++ + D L + + Q+ +G +
Sbjct: 2112 --------AFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRG-----I 2158
Query: 189 DRKDETKTQAIVCQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLD 248
KDE + ++L+LT ++ SGG ++ + A+ I DEP++ +D
Sbjct: 2159 SWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMD 2218
Query: 249 VKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVTMPFSVREG 308
K R I LI R +++ H + + L + + G + S++
Sbjct: 2219 PKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVN-----GRLRCLGSIQHL 2273
Query: 309 INIFLDGYVPT 319
N F DGY+ T
Sbjct: 2274 KNRFGDGYMIT 2284
Score = 48.9 bits (115), Expect = 1e-05
Identities = 49/214 (22%), Positives = 91/214 (42%), Gaps = 34/214 (15%)
Query: 345 MCMYKYPGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEG--- 401
+C+ K + K + L ++ +++++ LG NG GKTT + +L G P G
Sbjct: 991 VCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSAT 1050
Query: 402 -----------------GEVPVLNVSYKPQKISPK--STGSVRQLLHEKIRDAYTHPQFV 442
G P NV + + ++ + E+IR + +
Sbjct: 1051 IYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIR------REM 1104
Query: 443 TDVMKPLQIENIIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAAR 502
+++ L++ N VQTLSGG +++++A+ + ++DEP+A +D A R
Sbjct: 1105 DKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDP----YARR 1160
Query: 503 VVKRFILHAK--KTAFVVEHDFIMATYLADRVIV 534
+ IL K +T + H A L DR+ +
Sbjct: 1161 AIWDLILKYKPGRTILLSTHHMDEADLLGDRIAI 1194
Score = 45.1 bits (105), Expect = 2e-04
Identities = 43/191 (22%), Positives = 81/191 (42%), Gaps = 19/191 (9%)
Query: 104 EVLGLVGTNGIGKSTALKILAGKQKPNLGK-----YDDPPDWQEILTYFRGSELQNYFTK 158
+V+ +G NG GK+T + IL G P G +D + EI N
Sbjct: 1019 QVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHN---- 1074
Query: 159 ILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLS 218
+L D L + ++ A+ + +D+ + + L+L++ + V+ LS
Sbjct: 1075 VLFDRLTVEEHLWFYSRLKSMAQEEIRREMDK---------MIEDLELSNKRHSLVQTLS 1125
Query: 219 GGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSV 278
GG ++ + A+ + + + DEP++ +D R +A + P R I++ H +
Sbjct: 1126 GGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYAR-RAIWDLILKYKPGRTILLSTHHMDE 1184
Query: 279 LDYLSDFICCL 289
D L D I +
Sbjct: 1185 ADLLGDRIAII 1195
Score = 40.8 bits (94), Expect = 0.004
Identities = 47/203 (23%), Positives = 84/203 (41%), Gaps = 40/203 (19%)
Query: 313 LDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEFELAIVAGEFTDS 372
L G + ++ + + V+K + V ++C+ PG
Sbjct: 2042 LRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPG-------------------- 2081
Query: 373 EIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPV-------------LNVSYKPQ--KIS 417
E +LG NG GKT+ +ML G + GGE V ++ Y PQ +
Sbjct: 2082 ECFGLLGVNGAGKTSTFKMLTGD-ESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALF 2140
Query: 418 PKSTGSVRQLLHEKIRDAY--THPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALC 475
+ T L+ ++R + V ++ L++ D+ T SGG ++++ A+
Sbjct: 2141 DELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIA 2200
Query: 476 L-GKPADVYLIDEPSAYLDSEQR 497
L G PA ++L DEP+ +D + R
Sbjct: 2201 LIGYPAFIFL-DEPTTGMDPKAR 2222
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 55.1 bits (131), Expect = 2e-07
Identities = 57/251 (22%), Positives = 99/251 (39%), Gaps = 30/251 (11%)
Query: 78 NLEKETTHRYCANAFKLHRLPIP-RPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDD 136
NL K R + RL + RPGE GL+G NG GK++ K+L G + G+
Sbjct: 2085 NLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGE--- 2141
Query: 137 PPDWQEILTYFRGSELQNYFTKILE--------DDLKAIIKPQYVDQIPKAAKGTVGSIL 188
+ G + ++ + D L + + Q+ +G +
Sbjct: 2142 --------AFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRG-----I 2188
Query: 189 DRKDETKTQAIVCQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLD 248
KDE + ++L+LT ++ SGG ++ + A+ I DEP++ +D
Sbjct: 2189 SWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMD 2248
Query: 249 VKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVTMPFSVREG 308
K R I LI R +++ H + + L + + G + S++
Sbjct: 2249 PKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVN-----GRLRCLGSIQHL 2303
Query: 309 INIFLDGYVPT 319
N F DGY+ T
Sbjct: 2304 KNRFGDGYMIT 2314
Score = 48.9 bits (115), Expect = 1e-05
Identities = 49/214 (22%), Positives = 91/214 (42%), Gaps = 34/214 (15%)
Query: 345 MCMYKYPGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEG--- 401
+C+ K + K + L ++ +++++ LG NG GKTT + +L G P G
Sbjct: 1021 VCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSAT 1080
Query: 402 -----------------GEVPVLNVSYKPQKISPK--STGSVRQLLHEKIRDAYTHPQFV 442
G P NV + + ++ + E+IR + +
Sbjct: 1081 IYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIR------REM 1134
Query: 443 TDVMKPLQIENIIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAAR 502
+++ L++ N VQTLSGG +++++A+ + ++DEP+A +D A R
Sbjct: 1135 DKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDP----YARR 1190
Query: 503 VVKRFILHAK--KTAFVVEHDFIMATYLADRVIV 534
+ IL K +T + H A L DR+ +
Sbjct: 1191 AIWDLILKYKPGRTILLSTHHMDEADLLGDRIAI 1224
Score = 45.1 bits (105), Expect = 2e-04
Identities = 43/191 (22%), Positives = 81/191 (42%), Gaps = 19/191 (9%)
Query: 104 EVLGLVGTNGIGKSTALKILAGKQKPNLGK-----YDDPPDWQEILTYFRGSELQNYFTK 158
+V+ +G NG GK+T + IL G P G +D + EI N
Sbjct: 1049 QVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHN---- 1104
Query: 159 ILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLS 218
+L D L + ++ A+ + +D+ + + L+L++ + V+ LS
Sbjct: 1105 VLFDRLTVEEHLWFYSRLKSMAQEEIRREMDK---------MIEDLELSNKRHSLVQTLS 1155
Query: 219 GGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSV 278
GG ++ + A+ + + + DEP++ +D R +A + P R I++ H +
Sbjct: 1156 GGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYAR-RAIWDLILKYKPGRTILLSTHHMDE 1214
Query: 279 LDYLSDFICCL 289
D L D I +
Sbjct: 1215 ADLLGDRIAII 1225
Score = 40.8 bits (94), Expect = 0.004
Identities = 47/203 (23%), Positives = 84/203 (41%), Gaps = 40/203 (19%)
Query: 313 LDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEFELAIVAGEFTDS 372
L G + ++ + + V+K + V ++C+ PG
Sbjct: 2072 LRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPG-------------------- 2111
Query: 373 EIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPV-------------LNVSYKPQ--KIS 417
E +LG NG GKT+ +ML G + GGE V ++ Y PQ +
Sbjct: 2112 ECFGLLGVNGAGKTSTFKMLTGD-ESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALF 2170
Query: 418 PKSTGSVRQLLHEKIRDAY--THPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALC 475
+ T L+ ++R + V ++ L++ D+ T SGG ++++ A+
Sbjct: 2171 DELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIA 2230
Query: 476 L-GKPADVYLIDEPSAYLDSEQR 497
L G PA ++L DEP+ +D + R
Sbjct: 2231 LIGYPAFIFL-DEPTTGMDPKAR 2252
>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 53.9 bits (128), Expect = 4e-07
Identities = 50/199 (25%), Positives = 86/199 (43%), Gaps = 26/199 (13%)
Query: 101 RPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKIL 160
+ GE+LGL+G NG GKST + IL G +P G+ L +Y ++
Sbjct: 1324 KKGEILGLLGPNGAGKSTIINILVGDIEPTSGQV----------------FLGDYSSETS 1367
Query: 161 EDD--LKAI-----IKPQYVDQIPKAAKGTVGSI--LDRKDETKTQAIVCQQLDLTHLKE 211
EDD LK + I P + D + G++ + D + + + LDL +
Sbjct: 1368 EDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQ 1427
Query: 212 RNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLI-NPDRYII 270
+ V+ L G ++ A+ + I + DEPS+ +D K + IR+ N R I
Sbjct: 1428 KTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAI 1487
Query: 271 VVEHDLSVLDYLSDFICCL 289
+ H + + + D + +
Sbjct: 1488 LTTHYMEEAEAVCDRVAIM 1506
Score = 51.6 bits (122), Expect = 2e-06
Identities = 43/180 (23%), Positives = 79/180 (43%), Gaps = 19/180 (10%)
Query: 373 EIMVMLGENGTGKTTFIRMLAGRLKPDEG-------------GEVPVLNVSYKPQKISPK 419
EI+ +LG NG GK+T I +L G ++P G + + + Y PQ I+P
Sbjct: 1327 EILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQ-INPL 1385
Query: 420 STGSVRQLLHE-----KIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALAL 474
+ Q E K A + ++ + L ++ + + V+ L G +++ AL
Sbjct: 1386 WPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFAL 1445
Query: 475 CLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIV 534
+ + L+DEPS +D + + R ++ + K+ A + H A + DRV +
Sbjct: 1446 SMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAI 1505
Score = 50.1 bits (118), Expect = 6e-06
Identities = 59/227 (25%), Positives = 103/227 (45%), Gaps = 28/227 (12%)
Query: 332 KVAETANEEEVKKMCMYKYPGMKK---KMGEFELAI--VAGEFTDSEIMVMLGENGTGKT 386
++ E + E V K + + G++K K GE A+ ++ + + +I +LG +GTGK+
Sbjct: 463 EIIEPVSSEFVGKEAI-RISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKS 521
Query: 387 TFIRMLAGRLKPDEG---------GEVPVLNVSYKPQKISPK---------STGSVRQLL 428
T + +L G P +G E+ + + K I P+ ++ L
Sbjct: 522 TLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILA 581
Query: 429 HEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALC-LGKPADVYLIDE 487
K A Q V V+ L ++ I D + + LSGG+ ++++L + LG P + L+DE
Sbjct: 582 SIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNP-KILLLDE 640
Query: 488 PSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIV 534
P+A +D R + ++K A + H A LADR V
Sbjct: 641 PTAGMDPCSRHIVWNLLK--YRKANRVTVFSTHFMDEADILADRKAV 685
Score = 39.7 bits (91), Expect = 0.008
Identities = 47/226 (20%), Positives = 92/226 (40%), Gaps = 15/226 (6%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILED 162
G++ L+G +G GKST + IL G P+ G + I + R SE+ F
Sbjct: 507 GQITALLGHSGTGKSTLMNILCGLCPPSDG-------FASIYGH-RVSEIDEMFEARKMI 558
Query: 163 DLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAI--VCQQLDLTHLKERNVEDLSGG 220
+ + + + + SI Q + V LD+ +K+ + LSGG
Sbjct: 559 GICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGG 618
Query: 221 ELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLD 280
+ ++ + + + I + DEP++ +D R + +R + H + D
Sbjct: 619 QKRKLSLGIAVLGNPKILLLDEPTAGMDPCSR-HIVWNLLKYRKANRVTVFSTHFMDEAD 677
Query: 281 YLSDFICCL-YGVPSAYG---VVTMPFSVREGINIFLDGYVPTENL 322
L+D + G+ G + + + +++++D Y TE+L
Sbjct: 678 ILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESL 723
>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 53.9 bits (128), Expect = 4e-07
Identities = 50/199 (25%), Positives = 86/199 (43%), Gaps = 26/199 (13%)
Query: 101 RPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKIL 160
+ GE+LGL+G NG GKST + IL G +P G+ L +Y ++
Sbjct: 1324 KKGEILGLLGPNGAGKSTIINILVGDIEPTSGQV----------------FLGDYSSETS 1367
Query: 161 EDD--LKAI-----IKPQYVDQIPKAAKGTVGSI--LDRKDETKTQAIVCQQLDLTHLKE 211
EDD LK + I P + D + G++ + D + + + LDL +
Sbjct: 1368 EDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQ 1427
Query: 212 RNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLI-NPDRYII 270
+ V+ L G ++ A+ + I + DEPS+ +D K + IR+ N R I
Sbjct: 1428 KTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAI 1487
Query: 271 VVEHDLSVLDYLSDFICCL 289
+ H + + + D + +
Sbjct: 1488 LTTHYMEEAEAVCDRVAIM 1506
Score = 51.6 bits (122), Expect = 2e-06
Identities = 43/180 (23%), Positives = 79/180 (43%), Gaps = 19/180 (10%)
Query: 373 EIMVMLGENGTGKTTFIRMLAGRLKPDEG-------------GEVPVLNVSYKPQKISPK 419
EI+ +LG NG GK+T I +L G ++P G + + + Y PQ I+P
Sbjct: 1327 EILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQ-INPL 1385
Query: 420 STGSVRQLLHE-----KIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALAL 474
+ Q E K A + ++ + L ++ + + V+ L G +++ AL
Sbjct: 1386 WPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFAL 1445
Query: 475 CLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIV 534
+ + L+DEPS +D + + R ++ + K+ A + H A + DRV +
Sbjct: 1446 SMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAI 1505
Score = 50.1 bits (118), Expect = 6e-06
Identities = 59/227 (25%), Positives = 103/227 (45%), Gaps = 28/227 (12%)
Query: 332 KVAETANEEEVKKMCMYKYPGMKK---KMGEFELAI--VAGEFTDSEIMVMLGENGTGKT 386
++ E + E V K + + G++K K GE A+ ++ + + +I +LG +GTGK+
Sbjct: 463 EIIEPVSSEFVGKEAI-RISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKS 521
Query: 387 TFIRMLAGRLKPDEG---------GEVPVLNVSYKPQKISPK---------STGSVRQLL 428
T + +L G P +G E+ + + K I P+ ++ L
Sbjct: 522 TLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILA 581
Query: 429 HEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALC-LGKPADVYLIDE 487
K A Q V V+ L ++ I D + + LSGG+ ++++L + LG P + L+DE
Sbjct: 582 SIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNP-KILLLDE 640
Query: 488 PSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIV 534
P+A +D R + ++K A + H A LADR V
Sbjct: 641 PTAGMDPCSRHIVWNLLK--YRKANRVTVFSTHFMDEADILADRKAV 685
Score = 39.7 bits (91), Expect = 0.008
Identities = 47/226 (20%), Positives = 92/226 (40%), Gaps = 15/226 (6%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILED 162
G++ L+G +G GKST + IL G P+ G + I + R SE+ F
Sbjct: 507 GQITALLGHSGTGKSTLMNILCGLCPPSDG-------FASIYGH-RVSEIDEMFEARKMI 558
Query: 163 DLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAI--VCQQLDLTHLKERNVEDLSGG 220
+ + + + + SI Q + V LD+ +K+ + LSGG
Sbjct: 559 GICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGG 618
Query: 221 ELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLD 280
+ ++ + + + I + DEP++ +D R + +R + H + D
Sbjct: 619 QKRKLSLGIAVLGNPKILLLDEPTAGMDPCSR-HIVWNLLKYRKANRVTVFSTHFMDEAD 677
Query: 281 YLSDFICCL-YGVPSAYG---VVTMPFSVREGINIFLDGYVPTENL 322
L+D + G+ G + + + +++++D Y TE+L
Sbjct: 678 ILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESL 723
>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
[Homo sapiens]
Length = 663
Score = 51.6 bits (122), Expect = 2e-06
Identities = 48/177 (27%), Positives = 78/177 (44%), Gaps = 12/177 (6%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILED 162
GE++ ++G +G GKST + ILAG ++ + L FR ++ Y I++D
Sbjct: 108 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFR--KVSCY---IMQD 162
Query: 163 DLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAI--VCQQLDLTHLKERNVEDLSGG 220
D+ + P Q +A + L KDE + + + + L L LSGG
Sbjct: 163 DM---LLPHLTVQ--EAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGG 217
Query: 221 ELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLS 277
+ +R A A+ + + FDEP+S LD + ++ L R II H S
Sbjct: 218 QRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPS 274
Score = 50.8 bits (120), Expect = 3e-06
Identities = 42/172 (24%), Positives = 81/172 (47%), Gaps = 18/172 (10%)
Query: 351 PGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVS 410
P +KK + L ++G+F E++ ++G +G GK+T + +LAG + G V ++N
Sbjct: 87 PWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAV-LINGL 145
Query: 411 YKPQKISPKSTGSVRQ----LLHEKIRDAYT-------------HPQFVTDVMKPLQIEN 453
+ + K + + Q L H +++A + V +++ L + +
Sbjct: 146 PRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLS 205
Query: 454 IIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVK 505
+ +LSGG+ +R+A+AL L V DEP++ LDS ++K
Sbjct: 206 CANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 257
>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
[Homo sapiens]
Length = 644
Score = 51.6 bits (122), Expect = 2e-06
Identities = 48/177 (27%), Positives = 78/177 (44%), Gaps = 12/177 (6%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILED 162
GE++ ++G +G GKST + ILAG ++ + L FR ++ Y I++D
Sbjct: 89 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFR--KVSCY---IMQD 143
Query: 163 DLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAI--VCQQLDLTHLKERNVEDLSGG 220
D+ + P Q +A + L KDE + + + + L L LSGG
Sbjct: 144 DM---LLPHLTVQ--EAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGG 198
Query: 221 ELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLS 277
+ +R A A+ + + FDEP+S LD + ++ L R II H S
Sbjct: 199 QRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPS 255
Score = 50.8 bits (120), Expect = 3e-06
Identities = 42/172 (24%), Positives = 81/172 (47%), Gaps = 18/172 (10%)
Query: 351 PGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVS 410
P +KK + L ++G+F E++ ++G +G GK+T + +LAG + G V ++N
Sbjct: 68 PWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAV-LINGL 126
Query: 411 YKPQKISPKSTGSVRQ----LLHEKIRDAYT-------------HPQFVTDVMKPLQIEN 453
+ + K + + Q L H +++A + V +++ L + +
Sbjct: 127 PRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLS 186
Query: 454 IIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVK 505
+ +LSGG+ +R+A+AL L V DEP++ LDS ++K
Sbjct: 187 CANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 238
>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
[Homo sapiens]
Length = 668
Score = 51.6 bits (122), Expect = 2e-06
Identities = 48/177 (27%), Positives = 78/177 (44%), Gaps = 12/177 (6%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILED 162
GE++ ++G +G GKST + ILAG ++ + L FR ++ Y I++D
Sbjct: 113 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFR--KVSCY---IMQD 167
Query: 163 DLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAI--VCQQLDLTHLKERNVEDLSGG 220
D+ + P Q +A + L KDE + + + + L L LSGG
Sbjct: 168 DM---LLPHLTVQ--EAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGG 222
Query: 221 ELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLS 277
+ +R A A+ + + FDEP+S LD + ++ L R II H S
Sbjct: 223 QRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPS 279
Score = 50.8 bits (120), Expect = 3e-06
Identities = 42/172 (24%), Positives = 81/172 (47%), Gaps = 18/172 (10%)
Query: 351 PGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVS 410
P +KK + L ++G+F E++ ++G +G GK+T + +LAG + G V ++N
Sbjct: 92 PWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAV-LINGL 150
Query: 411 YKPQKISPKSTGSVRQ----LLHEKIRDAYT-------------HPQFVTDVMKPLQIEN 453
+ + K + + Q L H +++A + V +++ L + +
Sbjct: 151 PRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLS 210
Query: 454 IIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVK 505
+ +LSGG+ +R+A+AL L V DEP++ LDS ++K
Sbjct: 211 CANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 262
>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
[Homo sapiens]
Length = 677
Score = 51.6 bits (122), Expect = 2e-06
Identities = 48/177 (27%), Positives = 78/177 (44%), Gaps = 12/177 (6%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILED 162
GE++ ++G +G GKST + ILAG ++ + L FR ++ Y I++D
Sbjct: 122 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFR--KVSCY---IMQD 176
Query: 163 DLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAI--VCQQLDLTHLKERNVEDLSGG 220
D+ + P Q +A + L KDE + + + + L L LSGG
Sbjct: 177 DM---LLPHLTVQ--EAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGG 231
Query: 221 ELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLS 277
+ +R A A+ + + FDEP+S LD + ++ L R II H S
Sbjct: 232 QRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPS 288
Score = 50.8 bits (120), Expect = 3e-06
Identities = 42/172 (24%), Positives = 81/172 (47%), Gaps = 18/172 (10%)
Query: 351 PGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVS 410
P +KK + L ++G+F E++ ++G +G GK+T + +LAG + G V ++N
Sbjct: 101 PWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAV-LINGL 159
Query: 411 YKPQKISPKSTGSVRQ----LLHEKIRDAYT-------------HPQFVTDVMKPLQIEN 453
+ + K + + Q L H +++A + V +++ L + +
Sbjct: 160 PRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLS 219
Query: 454 IIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVK 505
+ +LSGG+ +R+A+AL L V DEP++ LDS ++K
Sbjct: 220 CANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 271
>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
[Homo sapiens]
Length = 678
Score = 51.6 bits (122), Expect = 2e-06
Identities = 48/177 (27%), Positives = 78/177 (44%), Gaps = 12/177 (6%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILED 162
GE++ ++G +G GKST + ILAG ++ + L FR ++ Y I++D
Sbjct: 111 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFR--KVSCY---IMQD 165
Query: 163 DLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAI--VCQQLDLTHLKERNVEDLSGG 220
D+ + P Q +A + L KDE + + + + L L LSGG
Sbjct: 166 DM---LLPHLTVQ--EAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGG 220
Query: 221 ELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLS 277
+ +R A A+ + + FDEP+S LD + ++ L R II H S
Sbjct: 221 QRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPS 277
Score = 50.8 bits (120), Expect = 3e-06
Identities = 42/172 (24%), Positives = 81/172 (47%), Gaps = 18/172 (10%)
Query: 351 PGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVS 410
P +KK + L ++G+F E++ ++G +G GK+T + +LAG + G V ++N
Sbjct: 90 PWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAV-LINGL 148
Query: 411 YKPQKISPKSTGSVRQ----LLHEKIRDAYT-------------HPQFVTDVMKPLQIEN 453
+ + K + + Q L H +++A + V +++ L + +
Sbjct: 149 PRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLS 208
Query: 454 IIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVK 505
+ +LSGG+ +R+A+AL L V DEP++ LDS ++K
Sbjct: 209 CANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 260
>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
[Homo sapiens]
Length = 666
Score = 51.6 bits (122), Expect = 2e-06
Identities = 48/177 (27%), Positives = 78/177 (44%), Gaps = 12/177 (6%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILED 162
GE++ ++G +G GKST + ILAG ++ + L FR ++ Y I++D
Sbjct: 111 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFR--KVSCY---IMQD 165
Query: 163 DLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAI--VCQQLDLTHLKERNVEDLSGG 220
D+ + P Q +A + L KDE + + + + L L LSGG
Sbjct: 166 DM---LLPHLTVQ--EAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGG 220
Query: 221 ELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLS 277
+ +R A A+ + + FDEP+S LD + ++ L R II H S
Sbjct: 221 QRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPS 277
Score = 50.8 bits (120), Expect = 3e-06
Identities = 42/172 (24%), Positives = 81/172 (47%), Gaps = 18/172 (10%)
Query: 351 PGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVS 410
P +KK + L ++G+F E++ ++G +G GK+T + +LAG + G V ++N
Sbjct: 90 PWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAV-LINGL 148
Query: 411 YKPQKISPKSTGSVRQ----LLHEKIRDAYT-------------HPQFVTDVMKPLQIEN 453
+ + K + + Q L H +++A + V +++ L + +
Sbjct: 149 PRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLS 208
Query: 454 IIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVK 505
+ +LSGG+ +R+A+AL L V DEP++ LDS ++K
Sbjct: 209 CANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 260
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 51.6 bits (122), Expect = 2e-06
Identities = 58/255 (22%), Positives = 108/255 (42%), Gaps = 39/255 (15%)
Query: 373 EIMVMLGENGTGKTTFIRMLAGRLKPDEGG------EVPVLNVSYKPQKISPKSTGSVR- 425
+ + ++G +G GK+T ++++ PDEG ++ NV+Y + I S V
Sbjct: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482
Query: 426 -------------QLLHEKIRDAYTHPQFVTDVMK-PLQIENIIDQEVQTLSGGELQRVA 471
+ ++I+ A +MK P + + ++ + LSGG+ QR+A
Sbjct: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542
Query: 472 LALCLGKPADVYLIDEPSAYLDSEQR------LMAARVVKRFILHAKKTAFVVEHDFIMA 525
+A L + + L+DE ++ LD+E L AR + I+ A + + V D I
Sbjct: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
Query: 526 TYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLE----------ITFRRDPNNYRP 575
D VIV G S+ L M SQ++ R PN ++
Sbjct: 603 --FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
Query: 576 RINKLNSIKDVEQKK 590
R+ + ++ K+++ +
Sbjct: 661 RLFRHSTQKNLKNSQ 675
Score = 43.9 bits (102), Expect = 4e-04
Identities = 55/232 (23%), Positives = 100/232 (43%), Gaps = 45/232 (19%)
Query: 368 EFTDSEIMVMLGENGTGKTTFIRML-------AGRLKPD------EGGEVPVLNVSYKPQ 414
E + + ++G +G GK+T +++L AG + D +G E LNV +
Sbjct: 1058 EVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRA 1117
Query: 415 KISPKSTGSV----------------RQLLHEKI----RDAYTHPQFVTDVMKPLQIENI 454
++ S + R + ++I + A HP T P + E
Sbjct: 1118 QLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIET---LPHKYETR 1174
Query: 455 IDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILHAK-- 512
+ + LSGG+ QR+A+A L + + L+DE ++ LD+E + +VV+ + A+
Sbjct: 1175 VGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTE----SEKVVQEALDKAREG 1230
Query: 513 KTAFVVEHDFIMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLEI 564
+T V+ H + AD ++VF K + Q LLA + S + +
Sbjct: 1231 RTCIVIAHR-LSTIQNADLIVVFQNGRVKE--HGTHQQLLAQKGIYFSMVSV 1279
Score = 43.1 bits (100), Expect = 7e-04
Identities = 48/186 (25%), Positives = 80/186 (43%), Gaps = 22/186 (11%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEI----LTYFRG-----SELQ 153
G+ + LVG++G GKST ++++ P+ G + D Q+I + Y R S+
Sbjct: 422 GQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINI--DGQDIRNFNVNYLREIIGVVSQEP 479
Query: 154 NYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERN 213
F+ + +++ +D+I KA K K K +V ER
Sbjct: 480 VLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLV---------GERG 530
Query: 214 VEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVE 273
+ LSGG+ QR A A ++ I + DE +S LD + + + R IV+
Sbjct: 531 AQ-LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAAL-DKAREGRTTIVIA 588
Query: 274 HDLSVL 279
H LS +
Sbjct: 589 HRLSTV 594
Score = 41.2 bits (95), Expect = 0.003
Identities = 51/189 (26%), Positives = 76/189 (40%), Gaps = 15/189 (7%)
Query: 101 RPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKIL 160
+ G+ L LVG++G GKST +++L P G +Q + G E + + L
Sbjct: 1060 KKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLL----DGQEAKKLNVQWL 1115
Query: 161 EDDLKAIIKPQYVDQIPKAAKGTVG--SILDRKDETKTQAIVCQQLD----LTHLKERNV 214
L + + + A G S + +DE + A L H E V
Sbjct: 1116 RAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRV 1175
Query: 215 ED----LSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYII 270
D LSGG+ QR A A I++ I + DE +S LD + K R I
Sbjct: 1176 GDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE-KVVQEALDKAREGRTCI 1234
Query: 271 VVEHDLSVL 279
V+ H LS +
Sbjct: 1235 VIAHRLSTI 1243
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 51.6 bits (122), Expect = 2e-06
Identities = 58/255 (22%), Positives = 108/255 (42%), Gaps = 39/255 (15%)
Query: 373 EIMVMLGENGTGKTTFIRMLAGRLKPDEGG------EVPVLNVSYKPQKISPKSTGSVR- 425
+ + ++G +G GK+T ++++ PDEG ++ NV+Y + I S V
Sbjct: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482
Query: 426 -------------QLLHEKIRDAYTHPQFVTDVMK-PLQIENIIDQEVQTLSGGELQRVA 471
+ ++I+ A +MK P + + ++ + LSGG+ QR+A
Sbjct: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542
Query: 472 LALCLGKPADVYLIDEPSAYLDSEQR------LMAARVVKRFILHAKKTAFVVEHDFIMA 525
+A L + + L+DE ++ LD+E L AR + I+ A + + V D I
Sbjct: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
Query: 526 TYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLE----------ITFRRDPNNYRP 575
D VIV G S+ L M SQ++ R PN ++
Sbjct: 603 --FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
Query: 576 RINKLNSIKDVEQKK 590
R+ + ++ K+++ +
Sbjct: 661 RLFRHSTQKNLKNSQ 675
Score = 45.1 bits (105), Expect = 2e-04
Identities = 55/226 (24%), Positives = 99/226 (43%), Gaps = 40/226 (17%)
Query: 368 EFTDSEIMVMLGENGTGKTTFIRML-------AGRLKPDEGGEVPVLNVSYKPQKISPKS 420
E + + ++G +G GK+T +++L AG + D G E LNV + ++ S
Sbjct: 1011 EVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLD-GQEAKKLNVQWLRAQLGIVS 1069
Query: 421 TGSV----------------RQLLHEKI----RDAYTHPQFVTDVMKPLQIENIIDQEVQ 460
+ R + ++I + A HP T P + E + +
Sbjct: 1070 QEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIET---LPHKYETRVGDKGT 1126
Query: 461 TLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILHAK--KTAFVV 518
LSGG+ QR+A+A L + + L+DE ++ LD+E + +VV+ + A+ +T V+
Sbjct: 1127 QLSGGQKQRIAIARALIRQPQILLLDEATSALDTE----SEKVVQEALDKAREGRTCIVI 1182
Query: 519 EHDFIMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLEI 564
H + AD ++VF K + Q LLA + S + +
Sbjct: 1183 AHR-LSTIQNADLIVVFQNGRVKE--HGTHQQLLAQKGIYFSMVSV 1225
Score = 43.1 bits (100), Expect = 7e-04
Identities = 48/186 (25%), Positives = 80/186 (43%), Gaps = 22/186 (11%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEI----LTYFRG-----SELQ 153
G+ + LVG++G GKST ++++ P+ G + D Q+I + Y R S+
Sbjct: 422 GQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINI--DGQDIRNFNVNYLREIIGVVSQEP 479
Query: 154 NYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERN 213
F+ + +++ +D+I KA K K K +V ER
Sbjct: 480 VLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLV---------GERG 530
Query: 214 VEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVE 273
+ LSGG+ QR A A ++ I + DE +S LD + + + R IV+
Sbjct: 531 AQ-LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAAL-DKAREGRTTIVIA 588
Query: 274 HDLSVL 279
H LS +
Sbjct: 589 HRLSTV 594
Score = 41.6 bits (96), Expect = 0.002
Identities = 51/189 (26%), Positives = 77/189 (40%), Gaps = 22/189 (11%)
Query: 101 RPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKIL 160
+ G+ L LVG++G GKST +++L ++ DP +L G E + + L
Sbjct: 1013 KKGQTLALVGSSGCGKSTVVQLLE--------RFYDPLAGTVLLD---GQEAKKLNVQWL 1061
Query: 161 EDDLKAIIKPQYVDQIPKAAKGTVG--SILDRKDETKTQAIVCQQLD----LTHLKERNV 214
L + + + A G S + +DE + A L H E V
Sbjct: 1062 RAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRV 1121
Query: 215 ED----LSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYII 270
D LSGG+ QR A A I++ I + DE +S LD + K R I
Sbjct: 1122 GDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE-KVVQEALDKAREGRTCI 1180
Query: 271 VVEHDLSVL 279
V+ H LS +
Sbjct: 1181 VIAHRLSTI 1189
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 51.6 bits (122), Expect = 2e-06
Identities = 58/255 (22%), Positives = 108/255 (42%), Gaps = 39/255 (15%)
Query: 373 EIMVMLGENGTGKTTFIRMLAGRLKPDEGG------EVPVLNVSYKPQKISPKSTGSVR- 425
+ + ++G +G GK+T ++++ PDEG ++ NV+Y + I S V
Sbjct: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482
Query: 426 -------------QLLHEKIRDAYTHPQFVTDVMK-PLQIENIIDQEVQTLSGGELQRVA 471
+ ++I+ A +MK P + + ++ + LSGG+ QR+A
Sbjct: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542
Query: 472 LALCLGKPADVYLIDEPSAYLDSEQR------LMAARVVKRFILHAKKTAFVVEHDFIMA 525
+A L + + L+DE ++ LD+E L AR + I+ A + + V D I
Sbjct: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
Query: 526 TYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLE----------ITFRRDPNNYRP 575
D VIV G S+ L M SQ++ R PN ++
Sbjct: 603 --FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
Query: 576 RINKLNSIKDVEQKK 590
R+ + ++ K+++ +
Sbjct: 661 RLFRHSTQKNLKNSQ 675
Score = 45.1 bits (105), Expect = 2e-04
Identities = 55/226 (24%), Positives = 99/226 (43%), Gaps = 40/226 (17%)
Query: 368 EFTDSEIMVMLGENGTGKTTFIRML-------AGRLKPDEGGEVPVLNVSYKPQKISPKS 420
E + + ++G +G GK+T +++L AG + D G E LNV + ++ S
Sbjct: 1058 EVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLD-GQEAKKLNVQWLRAQLGIVS 1116
Query: 421 TGSV----------------RQLLHEKI----RDAYTHPQFVTDVMKPLQIENIIDQEVQ 460
+ R + ++I + A HP T P + E + +
Sbjct: 1117 QEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIET---LPHKYETRVGDKGT 1173
Query: 461 TLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILHAK--KTAFVV 518
LSGG+ QR+A+A L + + L+DE ++ LD+E + +VV+ + A+ +T V+
Sbjct: 1174 QLSGGQKQRIAIARALIRQPQILLLDEATSALDTE----SEKVVQEALDKAREGRTCIVI 1229
Query: 519 EHDFIMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLEI 564
H + AD ++VF K + Q LLA + S + +
Sbjct: 1230 AHR-LSTIQNADLIVVFQNGRVKE--HGTHQQLLAQKGIYFSMVSV 1272
Score = 43.1 bits (100), Expect = 7e-04
Identities = 48/186 (25%), Positives = 80/186 (43%), Gaps = 22/186 (11%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEI----LTYFRG-----SELQ 153
G+ + LVG++G GKST ++++ P+ G + D Q+I + Y R S+
Sbjct: 422 GQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINI--DGQDIRNFNVNYLREIIGVVSQEP 479
Query: 154 NYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERN 213
F+ + +++ +D+I KA K K K +V ER
Sbjct: 480 VLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLV---------GERG 530
Query: 214 VEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVE 273
+ LSGG+ QR A A ++ I + DE +S LD + + + R IV+
Sbjct: 531 AQ-LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAAL-DKAREGRTTIVIA 588
Query: 274 HDLSVL 279
H LS +
Sbjct: 589 HRLSTV 594
Score = 41.6 bits (96), Expect = 0.002
Identities = 51/189 (26%), Positives = 77/189 (40%), Gaps = 22/189 (11%)
Query: 101 RPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKIL 160
+ G+ L LVG++G GKST +++L ++ DP +L G E + + L
Sbjct: 1060 KKGQTLALVGSSGCGKSTVVQLLE--------RFYDPLAGTVLLD---GQEAKKLNVQWL 1108
Query: 161 EDDLKAIIKPQYVDQIPKAAKGTVG--SILDRKDETKTQAIVCQQLD----LTHLKERNV 214
L + + + A G S + +DE + A L H E V
Sbjct: 1109 RAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRV 1168
Query: 215 ED----LSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYII 270
D LSGG+ QR A A I++ I + DE +S LD + K R I
Sbjct: 1169 GDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE-KVVQEALDKAREGRTCI 1227
Query: 271 VVEHDLSVL 279
V+ H LS +
Sbjct: 1228 VIAHRLSTI 1236
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 51.6 bits (122), Expect = 2e-06
Identities = 53/213 (24%), Positives = 97/213 (45%), Gaps = 30/213 (14%)
Query: 341 EVKKMCMYKYPGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDE 400
E KK C + KKK+ ++ + E++ +LG NG GK+T I+M+ G KP
Sbjct: 1207 ETKKSC---FSTRKKKIAIRNVSFCVKK---GEVLGLLGHNGAGKSTSIKMITGCTKPTA 1260
Query: 401 GGEVPVLN----------------VSYKPQKIS--PKSTGSVRQLLHEKIRDAYTHPQ-- 440
G V VL + Y PQ+ S PK T L+ ++
Sbjct: 1261 G--VVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAAL 1318
Query: 441 FVTDVMKPLQIENIIDQEVQTLSGGELQRVALAL-CLGKPADVYLIDEPSAYLDSEQRLM 499
++ +++ L+++ + V+TLS G +++ L LG P+ V L+DEP +D E +
Sbjct: 1319 SISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPS-VVLLDEPFTGMDPEGQQQ 1377
Query: 500 AARVVKRFILHAKKTAFVVEHDFIMATYLADRV 532
++++ + + ++ + H A + DR+
Sbjct: 1378 MWQILQATVKNKERGTLLTTHYMSEAEAVCDRM 1410
Score = 50.1 bits (118), Expect = 6e-06
Identities = 52/186 (27%), Positives = 82/186 (44%), Gaps = 30/186 (16%)
Query: 371 DSEIMVMLGENGTGKTTFIRMLAGRLKPDEGG--------------EVPVLNVSYKPQKI 416
+ +I +LG NG GK+T + +L+G EG E N+ + PQ
Sbjct: 419 EGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFN 478
Query: 417 SPKSTGSVRQLLHEKIRDAYTHP----QFVTDVMKPLQIENIIDQEVQTLSGGELQRVAL 472
+VR+ L + P Q V ++ L +++I D + LSGG+ +++ L
Sbjct: 479 FQFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTL 538
Query: 473 ALCLGKPADVYLIDEPSAYLDSEQR-----LMAARVVKRFILHAKKTAFVVEHDFIMATY 527
+ + V L+DEP+A LD R L+ V R IL + T F+ E D
Sbjct: 539 GIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFS--TQFMDEADI----- 591
Query: 528 LADRVI 533
LADR +
Sbjct: 592 LADRKV 597
Score = 46.2 bits (108), Expect = 9e-05
Identities = 46/192 (23%), Positives = 86/192 (44%), Gaps = 21/192 (10%)
Query: 101 RPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKI- 159
+ GEVLGL+G NG GKST++K++ G KP G +L R S Q + +
Sbjct: 1230 KKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVV--------VLQGSRASVRQQHDNSLK 1281
Query: 160 ------LEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERN 213
E+ L + + ++ A KG L ++D + + + + L L +
Sbjct: 1282 FLGYCPQENSLWPKLTMKEHLELYAAVKG-----LGKEDAALSISRLVEALKLQEQLKAP 1336
Query: 214 VEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVK-QRLKAAITIRSLINPDRYIIVV 272
V+ LS G ++ + + + + DEP + +D + Q+ I ++ N +R ++
Sbjct: 1337 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLT 1396
Query: 273 EHDLSVLDYLSD 284
H +S + + D
Sbjct: 1397 THYMSEAEAVCD 1408
Score = 41.6 bits (96), Expect = 0.002
Identities = 42/191 (21%), Positives = 79/191 (41%), Gaps = 25/191 (13%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLG-------KYDDPPDWQEILTYFRGSELQNY 155
G++ ++G NG GKST L IL+G G + + D +EI N+
Sbjct: 420 GQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNF 479
Query: 156 FTKIL--EDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERN 213
L ++L+ K + + PK + V I+ +LD+ +++
Sbjct: 480 QFDFLTVRENLRVFAKIKGIQ--PKEVEQEVKRII-------------MELDMQSIQDII 524
Query: 214 VEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVE 273
+ LSGG+ ++ + + + + DEP++ LD R + ++ DR I+
Sbjct: 525 AKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKE-HKVDRLILFST 583
Query: 274 HDLSVLDYLSD 284
+ D L+D
Sbjct: 584 QFMDEADILAD 594
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 50.4 bits (119), Expect = 5e-06
Identities = 38/132 (28%), Positives = 65/132 (49%), Gaps = 15/132 (11%)
Query: 374 IMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKSTGSVRQLLHEKIR 433
++ ++G G GK++ + L G L EG V+Y PQ+ ++T V + +
Sbjct: 658 LLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQEL 717
Query: 434 DAYTHPQFVTDVMK-----------PLQIENIIDQEVQTLSGGELQRVALALCLGKPADV 482
D P ++ V++ P I I ++ LSGG+ QR++LA + + A V
Sbjct: 718 D----PPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAV 773
Query: 483 YLIDEPSAYLDS 494
YL+D+P A LD+
Sbjct: 774 YLLDDPLAALDA 785
Score = 33.9 bits (76), Expect = 0.44
Identities = 43/168 (25%), Positives = 67/168 (39%), Gaps = 42/168 (25%)
Query: 94 LHRLPIPRP-GEVLGLVGTNGIGKSTALKILAGKQKPNLG--------KYDDPPDWQEIL 144
LHR+ + P G +L +VG G GKS+ L L G+ G Y W +
Sbjct: 646 LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNT 705
Query: 145 TYFR----GSELQNYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIV 200
+ G EL + LE L+A VD P+ ++G
Sbjct: 706 SVVENVCFGQELDPPW---LERVLEACALQPDVDSFPEGIHTSIG--------------- 747
Query: 201 CQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLD 248
E+ + +LSGG+ QR + A +KA +++ D+P + LD
Sbjct: 748 ----------EQGM-NLSGGQKQRLSLARAVYRKAAVYLLDDPLAALD 784
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 50.4 bits (119), Expect = 5e-06
Identities = 38/132 (28%), Positives = 65/132 (49%), Gaps = 15/132 (11%)
Query: 374 IMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKSTGSVRQLLHEKIR 433
++ ++G G GK++ + L G L EG V+Y PQ+ ++T V + +
Sbjct: 467 LLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQEL 526
Query: 434 DAYTHPQFVTDVMK-----------PLQIENIIDQEVQTLSGGELQRVALALCLGKPADV 482
D P ++ V++ P I I ++ LSGG+ QR++LA + + A V
Sbjct: 527 D----PPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAV 582
Query: 483 YLIDEPSAYLDS 494
YL+D+P A LD+
Sbjct: 583 YLLDDPLAALDA 594
Score = 33.9 bits (76), Expect = 0.44
Identities = 43/168 (25%), Positives = 67/168 (39%), Gaps = 42/168 (25%)
Query: 94 LHRLPIPRP-GEVLGLVGTNGIGKSTALKILAGKQKPNLG--------KYDDPPDWQEIL 144
LHR+ + P G +L +VG G GKS+ L L G+ G Y W +
Sbjct: 455 LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNT 514
Query: 145 TYFR----GSELQNYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIV 200
+ G EL + LE L+A VD P+ ++G
Sbjct: 515 SVVENVCFGQELDPPW---LERVLEACALQPDVDSFPEGIHTSIG--------------- 556
Query: 201 CQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLD 248
E+ + +LSGG+ QR + A +KA +++ D+P + LD
Sbjct: 557 ----------EQGM-NLSGGQKQRLSLARAVYRKAAVYLLDDPLAALD 593
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 49.3 bits (116), Expect = 1e-05
Identities = 44/143 (30%), Positives = 67/143 (46%), Gaps = 24/143 (16%)
Query: 373 EIMVMLGENGTGKTTFIRMLAGRLKPDEG-----------------GEVPVLNVSYKPQK 415
E +LG NG GK+T +ML G + G G VL + Y PQ+
Sbjct: 4748 ECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVL-IGYCPQQ 4806
Query: 416 --ISPKSTGSVRQLLHEKIRDAYTH--PQFVTDVMKPLQIENIIDQEVQTLSGGELQRVA 471
+ TG + +R P+ D+++ L +E D+ V T SGG ++++
Sbjct: 4807 DALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLS 4866
Query: 472 LALCL-GKPADVYLIDEPSAYLD 493
AL L GKP D+ L+DEPS+ +D
Sbjct: 4867 TALALVGKP-DILLLDEPSSGMD 4888
Score = 45.4 bits (106), Expect = 1e-04
Identities = 58/248 (23%), Positives = 93/248 (37%), Gaps = 66/248 (26%)
Query: 97 LPIPRPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYF 156
L IP+ GE GL+G NG GKST K+L G+ G
Sbjct: 4742 LGIPK-GECFGLLGVNGAGKSTTFKMLNGEVSLTSGH----------------------- 4777
Query: 157 TKILEDDLKAIIKPQYVDQIPKAAKGTVGSIL------DRKDETKT-------------- 196
AII+ D + ++ GT G ++ D DE T
Sbjct: 4778 ---------AIIRTPMGDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGI 4828
Query: 197 --QAI------VCQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLD 248
Q I + ++L L ++ V SGG ++ + A+ + K DI + DEPSS +D
Sbjct: 4829 PRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMD 4888
Query: 249 VKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVTMPFSVREG 308
+ TI + ++ H + + L + + V ++ + P ++
Sbjct: 4889 PCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLAIM--VNGSFKCLGSPQHIK-- 4944
Query: 309 INIFLDGY 316
N F DGY
Sbjct: 4945 -NRFGDGY 4951
Score = 43.9 bits (102), Expect = 4e-04
Identities = 50/205 (24%), Positives = 88/205 (42%), Gaps = 27/205 (13%)
Query: 349 KYPGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPV-- 406
+Y G K + + L F +I +LG NG GKTT I ML G L P G + +
Sbjct: 3850 EYEGHKAVVQDLSLT-----FYRDQITALLGTNGAGKTTIISMLTG-LHPPTSGTIIING 3903
Query: 407 -----------LNVSYKPQKISPKSTGSVRQ--LLHEKIR-DAYTHPQFVTDVMKPLQIE 452
+ + PQ+ +VR+ LL I+ +T + V + LQ
Sbjct: 3904 KNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDV 3963
Query: 453 NIID---QEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFIL 509
++ ++ + LSGG ++++L + + ++DEP++ +D R ++ ++
Sbjct: 3964 DLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKY-- 4021
Query: 510 HAKKTAFVVEHDFIMATYLADRVIV 534
+T H A L+DRV V
Sbjct: 4022 REGRTIIFTTHHLDEAEALSDRVAV 4046
Score = 41.6 bits (96), Expect = 0.002
Identities = 47/198 (23%), Positives = 79/198 (39%), Gaps = 31/198 (15%)
Query: 104 EVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTK----- 158
++ L+GTNG GK+T + +L G P G G LQ ++
Sbjct: 3869 QITALLGTNGAGKTTIISMLTGLHPPTSGTI-----------IINGKNLQTDLSRVRMEL 3917
Query: 159 -------ILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKE 211
IL D+L + + + KA + T + + ++T Q +DLT +
Sbjct: 3918 GVCPQQDILLDNL-TVREHLLLFASIKAPQWTKKELHQQVNQT------LQDVDLTQHQH 3970
Query: 212 RNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIV 271
+ LSGG ++ + + + + + DEP+S +D R + I R II
Sbjct: 3971 KQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSR-HSLWDILLKYREGRTIIF 4029
Query: 272 VEHDLSVLDYLSDFICCL 289
H L + LSD + L
Sbjct: 4030 TTHHLDEAEALSDRVAVL 4047
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 49.3 bits (116), Expect = 1e-05
Identities = 66/263 (25%), Positives = 110/263 (41%), Gaps = 41/263 (15%)
Query: 358 GEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKIS 417
G+ L+ ++ E + + ++G +G+GK+T +R+L +P +G ++ Q I
Sbjct: 485 GQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKG------SIYLAGQNIQ 538
Query: 418 PKSTGSVRQLLHEKIRDAY----------------THPQFVTDVMK-----------PLQ 450
S S+R+ + +DA P+ V V K P
Sbjct: 539 DVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHG 598
Query: 451 IENIIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILH 510
+ + + LSGGE QRVA+A + K V L DE ++ LDS +K + H
Sbjct: 599 YDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKH 658
Query: 511 AKKTAFVVEHDFIMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLEIT-FRRD 569
+T+ + H + AD +IV D K + LLA + S++ T R
Sbjct: 659 --RTSIFIAHR-LSTVVDADEIIVLD--QGKVAERGTHHGLLANPHSIYSEMWHTQSSRV 713
Query: 570 PNNYRPR--INKLNSIKDVEQKK 590
N+ P+ K N K+ E+KK
Sbjct: 714 QNHDNPKWEAKKENISKEEERKK 736
Score = 35.8 bits (81), Expect = 0.12
Identities = 37/155 (23%), Positives = 64/155 (41%), Gaps = 21/155 (13%)
Query: 103 GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILED 162
G+ + +VG +G GKST +++L +P G Y G +Q+ + L
Sbjct: 499 GKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSI-----------YLAGQNIQDVSLESLRR 547
Query: 163 DLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDL---------THLKERN 213
+ + + + G+I +E A + D T + ER
Sbjct: 548 AVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERG 607
Query: 214 VEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLD 248
++ LSGGE QR A A ++ + ++DE +S LD
Sbjct: 608 LK-LSGGEKQRVAIARAILKDPPVILYDEATSSLD 641
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 48.9 bits (115), Expect = 1e-05
Identities = 48/173 (27%), Positives = 81/173 (46%), Gaps = 10/173 (5%)
Query: 373 EIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKSTGSVRQ--LLHE 430
E++ ++G G GK++ + + G L P G ++Y Q+ S G++R L +
Sbjct: 439 ELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFS-GTLRSNILFGK 497
Query: 431 KI-RDAYTHPQFVTDVMKPLQIEN-----IIDQEVQTLSGGELQRVALALCLGKPADVYL 484
K ++ Y + K LQ+ +I TLSGG+ RV LA + + AD+YL
Sbjct: 498 KYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYL 557
Query: 485 IDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIVFDG 537
+D+P + +D+E + ILH K T +V H + +I+ DG
Sbjct: 558 LDDPLSAVDAEVSRHLFELCICQILHEKIT-ILVTHQLQYLKAASQILILKDG 609
Score = 44.7 bits (104), Expect = 2e-04
Identities = 53/201 (26%), Positives = 81/201 (40%), Gaps = 47/201 (23%)
Query: 101 RPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKIL 160
RPGE+L +VG G GKS+ L + G+ P+ G L G
Sbjct: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHG-----------LVSVHG----------- 473
Query: 161 EDDLKAIIKPQYVDQIPKAAKGTVGS--ILDRKDET------------KTQAIVCQQLDL 206
+ YV Q P GT+ S + +K E K + + DL
Sbjct: 474 --------RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDL 525
Query: 207 THLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVK-QRLKAAITIRSLINP 265
T + +R LSGG+ R A Q ADI++ D+P S +D + R + I +++
Sbjct: 526 TVIGDRGTT-LSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILH- 583
Query: 266 DRYIIVVEHDLSVLDYLSDFI 286
++ I+V H L L S +
Sbjct: 584 EKITILVTHQLQYLKAASQIL 604
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 48.9 bits (115), Expect = 1e-05
Identities = 48/173 (27%), Positives = 81/173 (46%), Gaps = 10/173 (5%)
Query: 373 EIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKSTGSVRQ--LLHE 430
E++ ++G G GK++ + + G L P G ++Y Q+ S G++R L +
Sbjct: 439 ELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFS-GTLRSNILFGK 497
Query: 431 KI-RDAYTHPQFVTDVMKPLQIEN-----IIDQEVQTLSGGELQRVALALCLGKPADVYL 484
K ++ Y + K LQ+ +I TLSGG+ RV LA + + AD+YL
Sbjct: 498 KYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYL 557
Query: 485 IDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIVFDG 537
+D+P + +D+E + ILH K T +V H + +I+ DG
Sbjct: 558 LDDPLSAVDAEVSRHLFELCICQILHEKIT-ILVTHQLQYLKAASQILILKDG 609
Score = 44.7 bits (104), Expect = 2e-04
Identities = 53/201 (26%), Positives = 81/201 (40%), Gaps = 47/201 (23%)
Query: 101 RPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKIL 160
RPGE+L +VG G GKS+ L + G+ P+ G L G
Sbjct: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHG-----------LVSVHG----------- 473
Query: 161 EDDLKAIIKPQYVDQIPKAAKGTVGS--ILDRKDET------------KTQAIVCQQLDL 206
+ YV Q P GT+ S + +K E K + + DL
Sbjct: 474 --------RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDL 525
Query: 207 THLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVK-QRLKAAITIRSLINP 265
T + +R LSGG+ R A Q ADI++ D+P S +D + R + I +++
Sbjct: 526 TVIGDRGTT-LSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILH- 583
Query: 266 DRYIIVVEHDLSVLDYLSDFI 286
++ I+V H L L S +
Sbjct: 584 EKITILVTHQLQYLKAASQIL 604
Score = 31.2 bits (69), Expect = 2.8
Identities = 46/170 (27%), Positives = 68/170 (40%), Gaps = 37/170 (21%)
Query: 95 HRLPIPRPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDW-QEILTYFRGSELQ 153
H + + E +G+VG G GKS+ + L +P GK W +ILT
Sbjct: 1060 HLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPE-GKI-----WIDKILT-------- 1105
Query: 154 NYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERN 213
T+I DL+ K + Q P GT+ LD +E T + L LKE
Sbjct: 1106 ---TEIGLHDLRK--KMSIIPQEPVLFTGTMRKNLDPFNE-HTDEELWNALQEVQLKE-T 1158
Query: 214 VEDLSG---------------GELQRFACAVVCIQKADIFMFDEPSSYLD 248
+EDL G G+ Q A ++K I + DE ++ +D
Sbjct: 1159 IEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVD 1208
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 48.5 bits (114), Expect = 2e-05
Identities = 57/203 (28%), Positives = 90/203 (44%), Gaps = 26/203 (12%)
Query: 101 RPGEVLGLVGTNGIGKSTALKILAGKQKPNLGK--YDDPPDWQEILTYFR------GSEL 152
RPGEV LVG NG GKST +L +P G+ D P Q Y G E
Sbjct: 589 RPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEP 648
Query: 153 QNYFTKILEDDLKAIIKPQYVDQIPKAA-KGTVGSILDRKDETKTQAIVCQQLDLTHLKE 211
Q + + E+ + + +++I AA K S + + Q D T + E
Sbjct: 649 QVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISG---------LPQGYD-TEVDE 698
Query: 212 RNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRY--- 268
LSGG+ Q A A I+K + + D+ +S LD +L+ + +P+RY
Sbjct: 699 AG-SQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYE--SPERYSRS 755
Query: 269 IIVVEHDLSVLDYLSDFICCLYG 291
++++ LS+++ +D I L G
Sbjct: 756 VLLITQHLSLVEQ-ADHILFLEG 777
Score = 40.0 bits (92), Expect = 0.006
Identities = 39/190 (20%), Positives = 82/190 (43%), Gaps = 29/190 (15%)
Query: 373 EIMVMLGENGTGKTTFIRMLAGRLKPD------EGGEVPVLNVSYKPQKISPKSTGSVRQ 426
E+ ++G NG+GK+T +L +P +G +P Y ++++ + G Q
Sbjct: 592 EVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVA--AVGQEPQ 649
Query: 427 L----LHEKIRDAYTHPQFVTDVMK--------------PLQIENIIDQEVQTLSGGELQ 468
+ L E I T + ++ P + +D+ LSGG+ Q
Sbjct: 650 VFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQ 709
Query: 469 RVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVV-KRFILHAKKTAFVVEHDFIMATY 527
VALA L + V ++D+ ++ LD+ +L +++ + +++ + +H +
Sbjct: 710 AVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQH--LSLVE 767
Query: 528 LADRVIVFDG 537
AD ++ +G
Sbjct: 768 QADHILFLEG 777
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,960,501
Number of Sequences: 37866
Number of extensions: 1064879
Number of successful extensions: 2907
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 79
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 2473
Number of HSP's gapped (non-prelim): 360
length of query: 599
length of database: 18,247,518
effective HSP length: 108
effective length of query: 491
effective length of database: 14,157,990
effective search space: 6951573090
effective search space used: 6951573090
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.