Search of human proteins with 10863901

Search of human proteins with 10863901

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|10863901 mitogen-activated protein kinase-activated protein
kinase 2 isoform 1 [Homo sapiens]
         (370 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|10863901 mitogen-activated protein kinase-activated protein k...   774   0.0  
gi|32481209 mitogen-activated protein kinase-activated protein k...   736   0.0  
gi|4758700 mitogen-activated protein kinase-activated protein ki...   484   e-137
gi|21237768 MAP kinase-activated protein kinase 5 isoform 2 [Hom...   259   3e-69
gi|21237765 MAP kinase-activated protein kinase 5 isoform 1 [Hom...   259   3e-69
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   201   9e-52
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   201   9e-52
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s...   193   2e-49
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo...   189   3e-48
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor...   187   1e-47
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo...   187   1e-47
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ...   187   2e-47
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca...   183   2e-46
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho...   183   2e-46
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca...   180   2e-45
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a...   179   4e-45
gi|27901803 protein serine kinase H1 [Homo sapiens]                   176   2e-44
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   175   5e-44
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   175   5e-44
gi|207113186 MAP kinase-interacting serine/threonine kinase 1 is...   170   2e-42
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]   168   6e-42
gi|39752689 MAP kinase-interacting serine/threonine kinase 1 iso...   166   2e-41
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is...   166   4e-41
gi|23943882 serine/threonine kinase 33 [Homo sapiens]                 162   3e-40
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso...   162   3e-40
gi|4758128 doublecortin-like kinase 1 [Homo sapiens]                  162   6e-40
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]              161   8e-40
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]               161   8e-40
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]      161   1e-39
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]      161   1e-39

>gi|10863901 mitogen-activated protein kinase-activated protein
           kinase 2 isoform 1 [Homo sapiens]
          Length = 370

 Score =  774 bits (1998), Expect = 0.0
 Identities = 370/370 (100%), Positives = 370/370 (100%)

Query: 1   MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII 60
           MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
Sbjct: 1   MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII 60

Query: 61  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI 120
           DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
Sbjct: 61  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI 120

Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180
           VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
Sbjct: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180

Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240
           NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
Sbjct: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240

Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300
           DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
Sbjct: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300

Query: 301 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKGCLHDKN 360
           LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKGCLHDKN
Sbjct: 301 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKGCLHDKN 360

Query: 361 SDQATWLTRL 370
           SDQATWLTRL
Sbjct: 361 SDQATWLTRL 370


>gi|32481209 mitogen-activated protein kinase-activated protein
           kinase 2 isoform 2 [Homo sapiens]
          Length = 400

 Score =  736 bits (1901), Expect = 0.0
 Identities = 353/353 (100%), Positives = 353/353 (100%)

Query: 1   MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII 60
           MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
Sbjct: 1   MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII 60

Query: 61  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI 120
           DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
Sbjct: 61  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI 120

Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180
           VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
Sbjct: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180

Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240
           NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
Sbjct: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240

Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300
           DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
Sbjct: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300

Query: 301 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVK 353
           LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVK
Sbjct: 301 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVK 353


>gi|4758700 mitogen-activated protein kinase-activated protein
           kinase 3 [Homo sapiens]
          Length = 382

 Score =  484 bits (1246), Expect = e-137
 Identities = 238/349 (68%), Positives = 280/349 (80%), Gaps = 22/349 (6%)

Query: 5   SQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYK 64
           ++ Q  PVP     PP  P  P L   P     P                KK A+ DDY+
Sbjct: 6   AEEQGGPVP-----PPVAPGGPGLGGAPGGRREP----------------KKYAVTDDYQ 44

Query: 65  VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVY 124
           ++ QVLGLG+NGKVL+ F++RT +K ALK+L D PKAR+EV+ HW+AS  PHIV I+DVY
Sbjct: 45  LSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVY 104

Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184
           EN++ G++CLLI+MEC++GGELFSRIQ+RGDQAFTEREA+EIM+ IG AIQ+LHS NIAH
Sbjct: 105 ENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAH 164

Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSC 244
           RDVKPENLLYTSK  +A+LKLTDFGFAKETT  N+L TPCYTPYYVAPEVLGPEKYDKSC
Sbjct: 165 RDVKPENLLYTSKEKDAVLKLTDFGFAKETTQ-NALQTPCYTPYYVAPEVLGPEKYDKSC 223

Query: 245 DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRN 304
           DMWSLGVIMYILLCG+PPFYSN G AISPGMK RIR+GQY FPNPEWSEVSE+ K LIR 
Sbjct: 224 DMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRL 283

Query: 305 LLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVK 353
           LLKT+PT+R+TIT+FMNHPWI QS  VPQTPLHT+RVL+EDK+ W++VK
Sbjct: 284 LLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVK 332


>gi|21237768 MAP kinase-activated protein kinase 5 isoform 2 [Homo
           sapiens]
          Length = 473

 Score =  259 bits (662), Expect = 3e-69
 Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 31/317 (9%)

Query: 54  IKKNAIIDDYKVT-SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRAS 112
           IK+ +I+++Y +  +Q LG GI+G V     K TQE+FALK+L D PKAR EV LH   +
Sbjct: 11  IKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCA 70

Query: 113 QCPHIVRIVDVYENLY------AGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166
             P+IV+I++V+ N        + R  LLIVME ++GGELF RI     + FTE++AS++
Sbjct: 71  THPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQH--RHFTEKQASQV 128

Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226
            K I  A+++ H +NIAHRD+KPENLL+     +A +KL DFGFAK       L TP +T
Sbjct: 129 TKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK--IDQGDLMTPQFT 186

Query: 227 PYYVAPEVL------------------GPEKYDKSCDMWSLGVIMYILLCGYPPFYS-NH 267
           PYYVAP+VL                   P  Y+KSCD+WSLGVI+Y++LCGYPPFYS +H
Sbjct: 187 PYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHH 246

Query: 268 GLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327
              I   M+ +I  G +EFP  EWS++SE  K ++R LLK +P +R+TI   ++HPW + 
Sbjct: 247 SRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPW-LN 305

Query: 328 STKVPQTPLHTSRVLKE 344
           ST+     L +++++ +
Sbjct: 306 STEALDNVLPSAQLMMD 322


>gi|21237765 MAP kinase-activated protein kinase 5 isoform 1 [Homo
           sapiens]
          Length = 471

 Score =  259 bits (662), Expect = 3e-69
 Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 31/317 (9%)

Query: 54  IKKNAIIDDYKVT-SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRAS 112
           IK+ +I+++Y +  +Q LG GI+G V     K TQE+FALK+L D PKAR EV LH   +
Sbjct: 11  IKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCA 70

Query: 113 QCPHIVRIVDVYENLY------AGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166
             P+IV+I++V+ N        + R  LLIVME ++GGELF RI     + FTE++AS++
Sbjct: 71  THPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQH--RHFTEKQASQV 128

Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226
            K I  A+++ H +NIAHRD+KPENLL+     +A +KL DFGFAK       L TP +T
Sbjct: 129 TKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK--IDQGDLMTPQFT 186

Query: 227 PYYVAPEVL------------------GPEKYDKSCDMWSLGVIMYILLCGYPPFYS-NH 267
           PYYVAP+VL                   P  Y+KSCD+WSLGVI+Y++LCGYPPFYS +H
Sbjct: 187 PYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHH 246

Query: 268 GLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327
              I   M+ +I  G +EFP  EWS++SE  K ++R LLK +P +R+TI   ++HPW + 
Sbjct: 247 SRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPW-LN 305

Query: 328 STKVPQTPLHTSRVLKE 344
           ST+     L +++++ +
Sbjct: 306 STEALDNVLPSAQLMMD 322


>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform b [Homo sapiens]
          Length = 744

 Score =  201 bits (511), Expect = 9e-52
 Identities = 111/308 (36%), Positives = 174/308 (56%), Gaps = 17/308 (5%)

Query: 32  PAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFA 91
           P  P  P      Q H        KN +  D  V  + +G+G   +  +  +K T  ++A
Sbjct: 402 PRAPQAPLHSVVQQLH-------GKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYA 454

Query: 92  LKMLQDCPK-ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI 150
           +K++    +    E+E+  R  Q P+I+ + DVY++     K + +V E + GGEL  +I
Sbjct: 455 VKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDD----GKHVYLVTELMRGGELLDKI 510

Query: 151 QDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNA-ILKLTDFG 209
             +  + F+EREAS ++ +IG+ ++YLHS  + HRD+KP N+LY  +  N   L++ DFG
Sbjct: 511 LRQ--KFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFG 568

Query: 210 FAKETTSHNSLT-TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG 268
           FAK+  + N L  TPCYT  +VAPEVL  + YD+ CD+WSLG+++Y +L GY PF +N  
Sbjct: 569 FAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPF-ANGP 627

Query: 269 LAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328
                 + TRI  G++      W+ VSE  K L+  +L  +P QR+T  + + HPW+ Q 
Sbjct: 628 SDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQK 687

Query: 329 TKVPQTPL 336
            K+PQ+ L
Sbjct: 688 DKLPQSQL 695



 Score =  100 bits (248), Expect = 3e-21
 Identities = 85/301 (28%), Positives = 144/301 (47%), Gaps = 41/301 (13%)

Query: 36  PPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQ-----------VLGLGINGKVL---QI 81
           P P P   PQ     G+ +K+ +I    K  S+           VLG G  GKV    ++
Sbjct: 33  PVPGPGSGPQRDSDEGV-LKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKV 91

Query: 82  FNKRTQEKFALKMLQDCP-----KARREVELHWRAS-QCPHIVRIVDVYENLYAGRKCLL 135
               +   +A+K+L+        + R ++E    A    P +V++   ++    G+  L 
Sbjct: 92  TRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQT--EGK--LY 147

Query: 136 IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT 195
           ++++ L GG+LF+R+    +  FTE +    +  +   + +LHS+ I +RD+KPEN+L  
Sbjct: 148 LILDFLRGGDLFTRLSK--EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLD 205

Query: 196 SKRPNAILKLTDFGFAKETTSHNSLTTP-CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMY 254
            +     +KLTDFG +KE   H       C T  Y+APEV+  + +  S D WS GV+M+
Sbjct: 206 EE---GHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMF 262

Query: 255 ILLCGYPPFY-SNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313
            +L G  PF   +    ++  +K ++ M Q+         +S E + L+R L K  P  R
Sbjct: 263 EMLTGSLPFQGKDRKETMTLILKAKLGMPQF---------LSTEAQSLLRALFKRNPANR 313

Query: 314 M 314
           +
Sbjct: 314 L 314


>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform a [Homo sapiens]
          Length = 735

 Score =  201 bits (511), Expect = 9e-52
 Identities = 111/308 (36%), Positives = 174/308 (56%), Gaps = 17/308 (5%)

Query: 32  PAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFA 91
           P  P  P      Q H        KN +  D  V  + +G+G   +  +  +K T  ++A
Sbjct: 393 PRAPQAPLHSVVQQLH-------GKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYA 445

Query: 92  LKMLQDCPK-ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI 150
           +K++    +    E+E+  R  Q P+I+ + DVY++     K + +V E + GGEL  +I
Sbjct: 446 VKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDD----GKHVYLVTELMRGGELLDKI 501

Query: 151 QDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNA-ILKLTDFG 209
             +  + F+EREAS ++ +IG+ ++YLHS  + HRD+KP N+LY  +  N   L++ DFG
Sbjct: 502 LRQ--KFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFG 559

Query: 210 FAKETTSHNSLT-TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG 268
           FAK+  + N L  TPCYT  +VAPEVL  + YD+ CD+WSLG+++Y +L GY PF +N  
Sbjct: 560 FAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPF-ANGP 618

Query: 269 LAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328
                 + TRI  G++      W+ VSE  K L+  +L  +P QR+T  + + HPW+ Q 
Sbjct: 619 SDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQK 678

Query: 329 TKVPQTPL 336
            K+PQ+ L
Sbjct: 679 DKLPQSQL 686



 Score = 99.0 bits (245), Expect = 6e-21
 Identities = 80/279 (28%), Positives = 138/279 (49%), Gaps = 33/279 (11%)

Query: 47  HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVL---QIFNKRTQEKFALKMLQDCP---- 99
           HVK+G +    +  +  KV    LG G  GKV    ++    +   +A+K+L+       
Sbjct: 49  HVKAGSEKADPSHFELLKV----LGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVR 104

Query: 100 -KARREVELHWRAS-QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQA 157
            + R ++E    A    P +V++   ++    G+  L ++++ L GG+LF+R+    +  
Sbjct: 105 DRVRTKMERDILADVNHPFVVKLHYAFQT--EGK--LYLILDFLRGGDLFTRLSK--EVM 158

Query: 158 FTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH 217
           FTE +    +  +   + +LHS+ I +RD+KPEN+L   +     +KLTDFG +KE   H
Sbjct: 159 FTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEE---GHIKLTDFGLSKEAIDH 215

Query: 218 NSLTTP-CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFY-SNHGLAISPGM 275
                  C T  Y+APEV+  + +  S D WS GV+M+ +L G  PF   +    ++  +
Sbjct: 216 EKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL 275

Query: 276 KTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM 314
           K ++ M Q+         +S E + L+R L K  P  R+
Sbjct: 276 KAKLGMPQF---------LSTEAQSLLRALFKRNPANRL 305


>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
           sapiens]
          Length = 370

 Score =  193 bits (490), Expect = 2e-49
 Identities = 109/291 (37%), Positives = 173/291 (59%), Gaps = 20/291 (6%)

Query: 69  VLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRAS-----QCPHIVRIVDV 123
           VLG G   +V+   +KRTQ+  A+K +       +E  +    +     + P+IV + D+
Sbjct: 25  VLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDI 84

Query: 124 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 183
           YE+   G   L ++M+ + GGELF RI ++G   +TER+AS ++  + +A++YLH + I 
Sbjct: 85  YES--GGH--LYLIMQLVSGGELFDRIVEKG--FYTERDASRLIFQVLDAVKYLHDLGIV 138

Query: 184 HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKS 243
           HRD+KPENLLY S   ++ + ++DFG +K     + L+T C TP YVAPEVL  + Y K+
Sbjct: 139 HRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKA 198

Query: 244 CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIR 303
            D WS+GVI YILLCGYPPFY  +   +      +I   +YEF +P W ++S+  K  IR
Sbjct: 199 VDCWSIGVIAYILLCGYPPFYDENDAKLF----EQILKAEYEFDSPYWDDISDSAKDFIR 254

Query: 304 NLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLH--TSRVLKED--KERWE 350
           +L++ +P +R T  + + HPWI   T + +  +H   S  +K++  K +W+
Sbjct: 255 HLMEKDPEKRFTCEQALQHPWIAGDTALDKN-IHQSVSEQIKKNFAKSKWK 304


>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
           sapiens]
          Length = 476

 Score =  189 bits (480), Expect = 3e-48
 Identities = 105/267 (39%), Positives = 158/267 (59%), Gaps = 17/267 (6%)

Query: 68  QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-----REVELHWRASQCPHIVRIVD 122
           +VLG G   +V  +  + T + FALK ++  P  R      E+ +  +     +IV + D
Sbjct: 27  EVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKH-ENIVTLED 85

Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182
           +YE+         +VM+ + GGELF RI +RG   +TE++AS +++ +  A++YLH   I
Sbjct: 86  IYESTTH----YYLVMQLVSGGELFDRILERG--VYTEKDASLVIQQVLSAVKYLHENGI 139

Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDK 242
            HRD+KPENLLY +   N+ + +TDFG +K    +  ++T C TP YVAPEVL  + Y K
Sbjct: 140 VHRDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVLAQKPYSK 198

Query: 243 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302
           + D WS+GVI YILLCGYPPFY          +  +I+ G YEF +P W ++SE  K  I
Sbjct: 199 AVDCWSIGVITYILLCGYPPFYEE----TESKLFEKIKEGYYEFESPFWDDISESAKDFI 254

Query: 303 RNLLKTEPTQRMTITEFMNHPWIMQST 329
            +LL+ +P +R T  + ++HPWI  +T
Sbjct: 255 CHLLEKDPNERYTCEKALSHPWIDGNT 281


>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
           [Homo sapiens]
          Length = 357

 Score =  187 bits (475), Expect = 1e-47
 Identities = 101/267 (37%), Positives = 155/267 (58%), Gaps = 15/267 (5%)

Query: 68  QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH-----WRASQCPHIVRIVD 122
           + LG G   +V+    K T + FA+K +       +E  +       R  +  +IV + D
Sbjct: 27  ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALED 86

Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182
           +YE+       L +VM+ + GGELF RI ++G   +TE++AS +++ + +A+ YLH + I
Sbjct: 87  IYES----PNHLYLVMQLVSGGELFDRIVEKG--FYTEKDASTLIRQVLDAVYYLHRMGI 140

Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDK 242
            HRD+KPENLLY S+   + + ++DFG +K     + ++T C TP YVAPEVL  + Y K
Sbjct: 141 VHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200

Query: 243 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302
           + D WS+GVI YILLCGYPPFY  +       +  +I   +YEF +P W ++S+  K  I
Sbjct: 201 AVDCWSIGVIAYILLCGYPPFYDEN----DSKLFEQILKAEYEFDSPYWDDISDSAKDFI 256

Query: 303 RNLLKTEPTQRMTITEFMNHPWIMQST 329
           RNL++ +P +R T  +   HPWI   T
Sbjct: 257 RNLMEKDPNKRYTCEQAARHPWIAGDT 283


>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
           2 [Homo sapiens]
          Length = 385

 Score =  187 bits (475), Expect = 1e-47
 Identities = 101/267 (37%), Positives = 155/267 (58%), Gaps = 15/267 (5%)

Query: 68  QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH-----WRASQCPHIVRIVD 122
           + LG G   +V+    K T + FA+K +       +E  +       R  +  +IV + D
Sbjct: 27  ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALED 86

Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182
           +YE+       L +VM+ + GGELF RI ++G   +TE++AS +++ + +A+ YLH + I
Sbjct: 87  IYES----PNHLYLVMQLVSGGELFDRIVEKG--FYTEKDASTLIRQVLDAVYYLHRMGI 140

Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDK 242
            HRD+KPENLLY S+   + + ++DFG +K     + ++T C TP YVAPEVL  + Y K
Sbjct: 141 VHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200

Query: 243 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302
           + D WS+GVI YILLCGYPPFY  +       +  +I   +YEF +P W ++S+  K  I
Sbjct: 201 AVDCWSIGVIAYILLCGYPPFYDEN----DSKLFEQILKAEYEFDSPYWDDISDSAKDFI 256

Query: 303 RNLLKTEPTQRMTITEFMNHPWIMQST 329
           RNL++ +P +R T  +   HPWI   T
Sbjct: 257 RNLMEKDPNKRYTCEQAARHPWIAGDT 283


>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
           sapiens]
          Length = 473

 Score =  187 bits (474), Expect = 2e-47
 Identities = 108/273 (39%), Positives = 161/273 (58%), Gaps = 14/273 (5%)

Query: 56  KNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ---DCPKARREVELHWRAS 112
           ++A+ D ++V S+ LG G    V +   K TQ+ +ALK+L+   D    R E+ +  R S
Sbjct: 39  RDALSDFFEVESE-LGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLS 97

Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172
             P+I+++ +++E        + +V+E + GGELF RI ++G   ++ER+A++ +K I E
Sbjct: 98  H-PNIIKLKEIFETPTE----ISLVLELVTGGELFDRIVEKG--YYSERDAADAVKQILE 150

Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAP 232
           A+ YLH   I HRD+KPENLLY +  P+A LK+ DFG +K       + T C TP Y AP
Sbjct: 151 AVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAP 210

Query: 233 EVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292
           E+L    Y    DMWS+G+I YILLCG+ PFY   G      M  RI   +Y F +P W 
Sbjct: 211 EILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERG---DQFMFRRILNCEYYFISPWWD 267

Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325
           EVS   K L+R L+  +P +R+T  + + HPW+
Sbjct: 268 EVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 300


>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
           kinase isoform a [Homo sapiens]
          Length = 426

 Score =  183 bits (465), Expect = 2e-46
 Identities = 114/300 (38%), Positives = 171/300 (57%), Gaps = 25/300 (8%)

Query: 40  PQQFPQFHVKSGLQIKKNA--IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD 97
           P + P   ++  L +KK+   I   Y++  + LG G   +V+    + +    ALK +  
Sbjct: 73  PSRIPAIALQDMLLLKKHTEDISSVYEIRER-LGSGAFSEVVLAQERGSAHLVALKCIPK 131

Query: 98  CPKARR--------EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSR 149
             KA R        E+ +  R S  P+IV + DV+E+       L + ME + GGELF R
Sbjct: 132 --KALRGKEALVENEIAVLRRISH-PNIVALEDVHES----PSHLYLAMELVTGGELFDR 184

Query: 150 IQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFG 209
           I +RG  ++TE++AS ++  +  A+ YLHS+ I HRD+KPENLLY +   ++ + ++DFG
Sbjct: 185 IMERG--SYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFG 242

Query: 210 FAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL 269
            +K   + N L T C TP YVAPE+L  + Y K+ D+W+LGVI YILLCGYPPFY     
Sbjct: 243 LSK-IQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDES-- 299

Query: 270 AISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329
              P + ++I    YEF +P W ++SE  K  IR+LL+ +P +R T  + + H WI   T
Sbjct: 300 --DPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDT 357


>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
           sapiens]
          Length = 740

 Score =  183 bits (464), Expect = 2e-46
 Identities = 104/290 (35%), Positives = 169/290 (58%), Gaps = 13/290 (4%)

Query: 53  QIKKNAI--IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK-ARREVELHW 109
           Q+ +N+I   D Y+V   + G+G      +  +K T  +FA+K++    +    E+E+  
Sbjct: 410 QLHRNSIQFTDGYEVKEDI-GVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILL 468

Query: 110 RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169
           R  Q P+I+ + DVY++     K + +V E + GGEL  +I  +  + F+EREAS ++ +
Sbjct: 469 RYGQHPNIITLKDVYDD----GKYVYVVTELMKGGELLDKILRQ--KFFSEREASAVLFT 522

Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNA-ILKLTDFGFAKETTSHNSLT-TPCYTP 227
           I + ++YLH+  + HRD+KP N+LY  +  N   +++ DFGFAK+  + N L  TPCYT 
Sbjct: 523 ITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTA 582

Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287
            +VAPEVL  + YD +CD+WSLGV++Y +L GY PF +N        +  RI  G++   
Sbjct: 583 NFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPF-ANGPDDTPEEILARIGSGKFSLS 641

Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLH 337
              W+ VS+  K L+  +L  +P QR+T    + HPWI+   ++PQ  L+
Sbjct: 642 GGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLN 691



 Score =  103 bits (256), Expect = 3e-22
 Identities = 78/258 (30%), Positives = 130/258 (50%), Gaps = 29/258 (11%)

Query: 68  QVLGLGINGKVL---QIFNKRTQEKFALKMLQDCP-KARREVELHWRAS-----QCPHIV 118
           +VLG G  GKV    +I     ++ +A+K+L+    K R  V              P IV
Sbjct: 72  KVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIV 131

Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178
           ++   ++    G+  L ++++ L GG+LF+R+    +  FTE +    +  +  A+ +LH
Sbjct: 132 KLHYAFQT--EGK--LYLILDFLRGGDLFTRLSK--EVMFTEEDVKFYLAELALALDHLH 185

Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP-CYTPYYVAPEVLGP 237
           S+ I +RD+KPEN+L   +     +KLTDFG +KE+  H       C T  Y+APEV+  
Sbjct: 186 SLGIIYRDLKPENILLDEE---GHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNR 242

Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPFY-SNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 296
             + +S D WS GV+M+ +L G  PF   +    ++  +K ++ M Q+         +S 
Sbjct: 243 RGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQF---------LSP 293

Query: 297 EVKMLIRNLLKTEPTQRM 314
           E + L+R L K  P  R+
Sbjct: 294 EAQSLLRMLFKRNPANRL 311


>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
           kinase isoform b [Homo sapiens]
          Length = 360

 Score =  180 bits (457), Expect = 2e-45
 Identities = 94/215 (43%), Positives = 136/215 (63%), Gaps = 11/215 (5%)

Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174
           P+IV + DV+E+       L + ME + GGELF RI +RG  ++TE++AS ++  +  A+
Sbjct: 88  PNIVALEDVHES----PSHLYLAMELVTGGELFDRIMERG--SYTEKDASHLVGQVLGAV 141

Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234
            YLHS+ I HRD+KPENLLY +   ++ + ++DFG +K   + N L T C TP YVAPE+
Sbjct: 142 SYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSK-IQAGNMLGTACGTPGYVAPEL 200

Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294
           L  + Y K+ D+W+LGVI YILLCGYPPFY        P + ++I    YEF +P W ++
Sbjct: 201 LEQKPYGKAVDVWALGVISYILLCGYPPFYDES----DPELFSQILRASYEFDSPFWDDI 256

Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329
           SE  K  IR+LL+ +P +R T  + + H WI   T
Sbjct: 257 SESAKDFIRHLLERDPQKRFTCQQALRHLWISGDT 291


>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
           [Homo sapiens]
          Length = 802

 Score =  179 bits (454), Expect = 4e-45
 Identities = 100/288 (34%), Positives = 166/288 (57%), Gaps = 14/288 (4%)

Query: 62  DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQC---PHIV 118
           D  +  + LG G      +  +K++ + FA+K++    +A  + E+      C   P+IV
Sbjct: 424 DLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEIT-ALKLCEGHPNIV 482

Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178
           ++ +V+ +    +    +VME L+GGELF RI+ +  + F+E EAS IM+ +  A+ ++H
Sbjct: 483 KLHEVFHD----QLHTFLVMELLNGGELFERIKKK--KHFSETEASYIMRKLVSAVSHMH 536

Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-LTTPCYTPYYVAPEVLGP 237
            + + HRD+KPENLL+T +  N  +K+ DFGFA+     N  L TPC+T +Y APE+L  
Sbjct: 537 DVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQ 596

Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYS-NHGLAISPGMK--TRIRMGQYEFPNPEWSEV 294
             YD+SCD+WSLGVI+Y +L G  PF S +  L  +  ++   +I+ G + F    W  V
Sbjct: 597 NGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNV 656

Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVL 342
           S+E K LI+ LL  +P +R+ ++    + W+   +++   PL T  +L
Sbjct: 657 SQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDIL 704



 Score =  104 bits (259), Expect = 1e-22
 Identities = 83/265 (31%), Positives = 134/265 (50%), Gaps = 33/265 (12%)

Query: 68  QVLGLGINGKVL---QIFNKRTQEKFALKMLQDCP-----------KARREVELHWRASQ 113
           +VLG G  GKV    +I    T + +A+K+L+              +  R+V  H R  Q
Sbjct: 53  KVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIR--Q 110

Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173
            P +V +   ++        L ++++ ++GGELF+ +  R  + FTE E    +  I  A
Sbjct: 111 SPFLVTLHYAFQT----ETKLHLILDYINGGELFTHLSQR--ERFTEHEVQIYVGEIVLA 164

Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPCYTPYYVA 231
           +++LH + I +RD+K EN+L  S   N  + LTDFG +KE  +  +    + C T  Y+A
Sbjct: 165 LEHLHKLGIIYRDIKLENILLDS---NGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221

Query: 232 PEVL--GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289
           P+++  G   +DK+ D WSLGV+MY LL G  PF  +        +  RI   +  +P  
Sbjct: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYP-- 279

Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRM 314
              E+S   K LI+ LL  +P +R+
Sbjct: 280 --QEMSALAKDLIQRLLMKDPKKRL 302


>gi|27901803 protein serine kinase H1 [Homo sapiens]
          Length = 424

 Score =  176 bits (447), Expect = 2e-44
 Identities = 119/367 (32%), Positives = 192/367 (52%), Gaps = 42/367 (11%)

Query: 14  FPAPA----PPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQ- 68
           FPA +    P P PPT     PP++PP                ++ K     D +VT++ 
Sbjct: 52  FPAASQYAHPCPGPPTAGHTEPPSEPP-------------RRARVAKYRAKFDPRVTAKY 98

Query: 69  ----VLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREV---ELH-WRASQCPHIVRI 120
               ++G G   +V+++ ++ T++ +A+KM++   +  REV   EL   R  +  +I+++
Sbjct: 99  DIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQL 158

Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180
           V+V+E     ++ + +VME   GGELF RI  +G  +FTER+A+ +++ + + ++YLH++
Sbjct: 159 VEVFET----QERVYMVMELATGGELFDRIIAKG--SFTERDATRVLQMVLDGVRYLHAL 212

Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPCYTPYYVAPEVLGPE 238
            I HRD+KPENLLY     ++ + +TDFG A      +   + T C TP Y+APEVL  +
Sbjct: 213 GITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRK 272

Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEV 298
            Y  S DMW+LGVI YILL G  PF  ++       +  +I  G+Y +    W  VS   
Sbjct: 273 PYTNSVDMWALGVIAYILLSGTMPFEDDN----RTRLYRQILRGKYSYSGEPWPSVSNLA 328

Query: 299 KMLIRNLLKTEPTQRMTITEFMNHPWIM-QSTKVPQTPLHTS---RVLKEDKERWEDVKG 354
           K  I  LL  +P  RMT  + + HPW++  +       LH S    +LK    R +  K 
Sbjct: 329 KDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSRCQSTKS 388

Query: 355 CLHDKNS 361
               ++S
Sbjct: 389 AQSTRSS 395


>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform b [Homo sapiens]
          Length = 741

 Score =  175 bits (444), Expect = 5e-44
 Identities = 97/270 (35%), Positives = 159/270 (58%), Gaps = 13/270 (4%)

Query: 61  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK-ARREVELHWRASQCPHIVR 119
           D Y++   + G+G      +  +K T  ++A+K++    +    E+E+  R  Q P+I+ 
Sbjct: 421 DGYEIKEDI-GVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIIT 479

Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179
           + DVY++     K + +VME + GGEL  RI  +  + F+EREAS+++ +I + + YLHS
Sbjct: 480 LKDVYDD----GKFVYLVMELMRGGELLDRILRQ--RYFSEREASDVLCTITKTMDYLHS 533

Query: 180 INIAHRDVKPENLLYT--SKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLG 236
             + HRD+KP N+LY   S  P +I ++ DFGFAK+  + N L  TPCYT  +VAPEVL 
Sbjct: 534 QGVVHRDLKPSNILYRDESGSPESI-RVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLK 592

Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 296
            + YD +CD+WSLG+++Y +L G+ PF +N        +  RI  G+Y      W  +S+
Sbjct: 593 RQGYDAACDIWSLGILLYTMLAGFTPF-ANGPDDTPEEILARIGSGKYALSGGNWDSISD 651

Query: 297 EVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326
             K ++  +L  +P QR+T  + + HPW++
Sbjct: 652 AAKDVVSKMLHVDPHQRLTAMQVLKHPWVV 681



 Score =  103 bits (257), Expect = 2e-22
 Identities = 84/298 (28%), Positives = 147/298 (49%), Gaps = 42/298 (14%)

Query: 47  HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVL-----------QIFNKRTQEKFALKML 95
           HVK G +    +  +  KV    LG G  GKV            Q++  +  +K  LK+ 
Sbjct: 54  HVKEGFEKADPSQFELLKV----LGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKV- 108

Query: 96  QDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD 155
           +D  +++ E ++    +  P IV++   ++    G+  L ++++ L GG+LF+R+    +
Sbjct: 109 RDRVRSKMERDILAEVNH-PFIVKLHYAFQT--EGK--LYLILDFLRGGDLFTRLSK--E 161

Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215
             FTE +    +  +  A+ +LHS+ I +RD+KPEN+L   +     +K+TDFG +KE  
Sbjct: 162 VMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEE---GHIKITDFGLSKEAI 218

Query: 216 SHNSLTTP-CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFY-SNHGLAISP 273
            H+      C T  Y+APEV+    + +S D WS GV+M+ +L G  PF   +    ++ 
Sbjct: 219 DHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMAL 278

Query: 274 GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIM 326
            +K ++ M Q+         +S E + L+R L K  P  R+      + E   HP+ +
Sbjct: 279 ILKAKLGMPQF---------LSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFV 327


>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform a [Homo sapiens]
          Length = 733

 Score =  175 bits (444), Expect = 5e-44
 Identities = 97/270 (35%), Positives = 159/270 (58%), Gaps = 13/270 (4%)

Query: 61  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK-ARREVELHWRASQCPHIVR 119
           D Y++   + G+G      +  +K T  ++A+K++    +    E+E+  R  Q P+I+ 
Sbjct: 413 DGYEIKEDI-GVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIIT 471

Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179
           + DVY++     K + +VME + GGEL  RI  +  + F+EREAS+++ +I + + YLHS
Sbjct: 472 LKDVYDD----GKFVYLVMELMRGGELLDRILRQ--RYFSEREASDVLCTITKTMDYLHS 525

Query: 180 INIAHRDVKPENLLYT--SKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLG 236
             + HRD+KP N+LY   S  P +I ++ DFGFAK+  + N L  TPCYT  +VAPEVL 
Sbjct: 526 QGVVHRDLKPSNILYRDESGSPESI-RVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLK 584

Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 296
            + YD +CD+WSLG+++Y +L G+ PF +N        +  RI  G+Y      W  +S+
Sbjct: 585 RQGYDAACDIWSLGILLYTMLAGFTPF-ANGPDDTPEEILARIGSGKYALSGGNWDSISD 643

Query: 297 EVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326
             K ++  +L  +P QR+T  + + HPW++
Sbjct: 644 AAKDVVSKMLHVDPHQRLTAMQVLKHPWVV 673



 Score =  103 bits (257), Expect = 2e-22
 Identities = 84/298 (28%), Positives = 147/298 (49%), Gaps = 42/298 (14%)

Query: 47  HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVL-----------QIFNKRTQEKFALKML 95
           HVK G +    +  +  KV    LG G  GKV            Q++  +  +K  LK+ 
Sbjct: 46  HVKEGFEKADPSQFELLKV----LGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKV- 100

Query: 96  QDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD 155
           +D  +++ E ++    +  P IV++   ++    G+  L ++++ L GG+LF+R+    +
Sbjct: 101 RDRVRSKMERDILAEVNH-PFIVKLHYAFQT--EGK--LYLILDFLRGGDLFTRLSK--E 153

Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215
             FTE +    +  +  A+ +LHS+ I +RD+KPEN+L   +     +K+TDFG +KE  
Sbjct: 154 VMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEE---GHIKITDFGLSKEAI 210

Query: 216 SHNSLTTP-CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFY-SNHGLAISP 273
            H+      C T  Y+APEV+    + +S D WS GV+M+ +L G  PF   +    ++ 
Sbjct: 211 DHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMAL 270

Query: 274 GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIM 326
            +K ++ M Q+         +S E + L+R L K  P  R+      + E   HP+ +
Sbjct: 271 ILKAKLGMPQF---------LSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFV 319


>gi|207113186 MAP kinase-interacting serine/threonine kinase 1
           isoform 3 [Homo sapiens]
          Length = 424

 Score =  170 bits (430), Expect = 2e-42
 Identities = 103/314 (32%), Positives = 169/314 (53%), Gaps = 37/314 (11%)

Query: 61  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKARREVELHWRASQCP 115
           D YK+TS++LG G   KV    + +  +++A+K+++        +  REVE  ++     
Sbjct: 46  DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNK 105

Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175
           +I+ +++ +E+         +V E L GG + + IQ +  + F EREAS +++ +  A+ 
Sbjct: 106 NILELIEFFED----DTRFYLVFEKLQGGSILAHIQKQ--KHFNEREASRVVRDVAAALD 159

Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--------LTTPCYTP 227
           +LH+  IAHRD+KPEN+L  S    + +K+ DF        +NS        LTTPC + 
Sbjct: 160 FLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 219

Query: 228 YYVAPEVL-----GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-----------AI 271
            Y+APEV+         YDK CD+WSLGV++YI+L GYPPF  + G              
Sbjct: 220 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 279

Query: 272 SPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331
              +   I+ G+YEFP+ +W+ +S E K LI  LL  +  QR++  + + HPW+    + 
Sbjct: 280 QNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV--QGQA 337

Query: 332 PQTPLHTSRVLKED 345
           P+  L T +VL+ +
Sbjct: 338 PEKGLPTPQVLQRN 351


>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
          Length = 745

 Score =  168 bits (426), Expect = 6e-42
 Identities = 92/266 (34%), Positives = 150/266 (56%), Gaps = 10/266 (3%)

Query: 70  LGLGINGKVLQIFNKRTQEKFALKMLQDCPK-ARREVELHWRASQCPHIVRIVDVYENLY 128
           +G+G      +  +  T  +FA+K++    +    E+E+  R  Q P+I+ + DV+++  
Sbjct: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDD-- 489

Query: 129 AGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVK 188
              + + +V + + GGEL  RI  +  + F+EREAS+I+  I + + YLH   + HRD+K
Sbjct: 490 --GRYVYLVTDLMKGGELLDRILKQ--KCFSEREASDILYVISKTVDYLHCQGVVHRDLK 545

Query: 189 PENLLYTSKRPNA-ILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLGPEKYDKSCDM 246
           P N+LY  +  +A  +++ DFGFAK+    N L  TPCYT  +VAPEVL  + YD +CD+
Sbjct: 546 PSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDI 605

Query: 247 WSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLL 306
           WSLGV+ Y +L GY PF +N        +  RI  G++      W  +S+  K L+ ++L
Sbjct: 606 WSLGVLFYTMLAGYTPF-ANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHML 664

Query: 307 KTEPTQRMTITEFMNHPWIMQSTKVP 332
             +P QR T  + + H WI    ++P
Sbjct: 665 HMDPHQRYTAEQILKHSWITHRDQLP 690



 Score = 98.6 bits (244), Expect = 8e-21
 Identities = 80/281 (28%), Positives = 138/281 (49%), Gaps = 37/281 (13%)

Query: 47  HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVL-----------QIFNKRTQEKFALKML 95
           HVK G +    A  +  KV    LG G  GKV            Q++  +  +K +LK+ 
Sbjct: 60  HVKEGYEKADPAQFELLKV----LGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKV- 114

Query: 96  QDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD 155
           +D  + + E ++    +  P IV++   ++    G+  L ++++ L GG++F+R+    +
Sbjct: 115 RDRVRTKMERDILVEVNH-PFIVKLHYAFQT--EGK--LYLILDFLRGGDVFTRLSK--E 167

Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215
             FTE +    +  +  A+ +LH + I +RD+KPEN+L         +KLTDFG +KE+ 
Sbjct: 168 VLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEI---GHIKLTDFGLSKESV 224

Query: 216 SHNSLTTP-CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFY-SNHGLAISP 273
                    C T  Y+APEV+    + +S D WS GV+M+ +L G  PF   +    ++ 
Sbjct: 225 DQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNM 284

Query: 274 GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM 314
            +K ++ M Q+         +S E + L+R L K  P  R+
Sbjct: 285 ILKAKLGMPQF---------LSAEAQSLLRMLFKRNPANRL 316


>gi|39752689 MAP kinase-interacting serine/threonine kinase 1
           isoform 2 [Homo sapiens]
          Length = 347

 Score =  166 bits (421), Expect = 2e-41
 Identities = 98/294 (33%), Positives = 159/294 (54%), Gaps = 35/294 (11%)

Query: 61  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKARREVELHWRASQCP 115
           D YK+TS++LG G   KV    + +  +++A+K+++        +  REVE  ++     
Sbjct: 46  DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNK 105

Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175
           +I+ +++ +E+         +V E L GG + + IQ +  + F EREAS +++ +  A+ 
Sbjct: 106 NILELIEFFED----DTRFYLVFEKLQGGSILAHIQKQ--KHFNEREASRVVRDVAAALD 159

Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--------LTTPCYTP 227
           +LH+  IAHRD+KPEN+L  S    + +K+ DF        +NS        LTTPC + 
Sbjct: 160 FLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 219

Query: 228 YYVAPEVL-----GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-----------AI 271
            Y+APEV+         YDK CD+WSLGV++YI+L GYPPF  + G              
Sbjct: 220 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 279

Query: 272 SPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325
              +   I+ G+YEFP+ +W+ +S E K LI  LL  +  QR++  + + HPW+
Sbjct: 280 QNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333


>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
           isoform b [Homo sapiens]
          Length = 766

 Score =  166 bits (419), Expect = 4e-41
 Identities = 106/349 (30%), Positives = 177/349 (50%), Gaps = 42/349 (12%)

Query: 31  PPAQPPPPPPQQFPQFH--------------VKSGLQ------------IKKNAIIDDYK 64
           PP  PPP  P+ F  +               +  GL+            + ++A++  Y+
Sbjct: 344 PPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYE 403

Query: 65  VTSQ--VLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA--RREVELHWRASQCPHIVRI 120
           +  +   LG G      +   +++ ++FA+K+L    +A  +REV         P++V +
Sbjct: 404 LDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNL 463

Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS- 179
            +V+ +    +    +V+E L GGEL   I+ +  + F+E EAS+I++S+  A+ ++H  
Sbjct: 464 HEVHHD----QLHTYLVLELLRGGELLEHIRKK--RHFSESEASQILRSLVSAVSFMHEE 517

Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPCYTPYYVAPEVLGP 237
             + HRD+KPEN+LY    P A +K+ DFGFA+         + TPC+T  Y APE+L  
Sbjct: 518 AGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQ 577

Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPFY---SNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294
           + YD+SCD+WSLGVI+Y++L G  PF       G + +  +  +IR G++      W  V
Sbjct: 578 QGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGV 637

Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLK 343
           SEE K L+R LL  +P +R+ +       W+   +     PL T  VL+
Sbjct: 638 SEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLE 686



 Score = 85.5 bits (210), Expect = 7e-17
 Identities = 78/277 (28%), Positives = 131/277 (47%), Gaps = 33/277 (11%)

Query: 68  QVLGLGINGKVLQIFNKRTQEK---FALKMLQDCPKARR-EVELHWRAS--------QCP 115
           +VLG G  GKV  +      +    +A+K+L+     +R + + H R          Q P
Sbjct: 37  KVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAP 96

Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175
            +V +   ++        L ++++ + GGE+F+ +  R  Q F E E       I  A++
Sbjct: 97  FLVTLHYAFQT----DAKLHLILDYVSGGEMFTHLYQR--QYFKEAEVRVYGGEIVLALE 150

Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE--TTSHNSLTTPCYTPYYVAPE 233
           +LH + I +RD+K EN+L  S+     + LTDFG +KE  T       + C T  Y+APE
Sbjct: 151 HLHKLGIIYRDLKLENVLLDSE---GHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPE 207

Query: 234 VLGPEK-YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292
           ++  +  + K+ D WSLG++++ LL G  PF           +  RI      FP P   
Sbjct: 208 IIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFP-PRIG 266

Query: 293 EVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPW 324
            V+++   L++ LL  +P +R+        E  NHP+
Sbjct: 267 PVAQD---LLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300


>gi|23943882 serine/threonine kinase 33 [Homo sapiens]
          Length = 514

 Score =  162 bits (411), Expect = 3e-40
 Identities = 100/316 (31%), Positives = 167/316 (52%), Gaps = 24/316 (7%)

Query: 52  LQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWR- 110
           ++I+  A I++     ++LG G  G V++  +K T+ K+A+K +         V+L  R 
Sbjct: 104 IRIENGAAIEEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLERE 163

Query: 111 -----ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165
                + +  HI+ +  V+E      K + +VME  + GEL   +  +G   F+E E   
Sbjct: 164 VNILKSVKHEHIIHLEQVFET----PKKMYLVMELCEDGELKEILDRKGH--FSENETRW 217

Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSK------RPNAILKLTDFGFA--KETTSH 217
           I++S+  AI YLH+ +I HRD+K EN++  S         N  +K+TDFG A  K++ S 
Sbjct: 218 IIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSE 277

Query: 218 NSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKT 277
             L   C TP Y+APEV+    Y + CD+WS+GV+MY+LL G PPF ++        +  
Sbjct: 278 AMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASS----EEKLFE 333

Query: 278 RIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLH 337
            IR G+  F N  W+ +S+  K +++ L+K +P  R+T  E +++ W+  +      P +
Sbjct: 334 LIRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTN 393

Query: 338 TSRVLKEDKERWEDVK 353
              ++KE K   E V+
Sbjct: 394 VLEMMKEWKNNPESVE 409


>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
           isoform a [Homo sapiens]
          Length = 772

 Score =  162 bits (411), Expect = 3e-40
 Identities = 107/355 (30%), Positives = 175/355 (49%), Gaps = 48/355 (13%)

Query: 31  PPAQPPPPPPQQFPQFH--------------VKSGLQ------------IKKNAIIDDYK 64
           PP  PPP  P+ F  +               +  GL+            + ++A++ D  
Sbjct: 344 PPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSP 403

Query: 65  VTSQ--------VLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA--RREVELHWRASQC 114
              Q         LG G      +   +++ ++FA+K+L    +A  +REV         
Sbjct: 404 FFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSH 463

Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174
           P++V + +V+ +    +    +V+E L GGEL   I+ +  + F+E EAS+I++S+  A+
Sbjct: 464 PNVVNLHEVHHD----QLHTYLVLELLRGGELLEHIRKK--RHFSESEASQILRSLVSAV 517

Query: 175 QYLHS-INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPCYTPYYVA 231
            ++H    + HRD+KPEN+LY    P A +K+ DFGFA+         + TPC+T  Y A
Sbjct: 518 SFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAA 577

Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFY---SNHGLAISPGMKTRIRMGQYEFPN 288
           PE+L  + YD+SCD+WSLGVI+Y++L G  PF       G + +  +  +IR G++    
Sbjct: 578 PELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDG 637

Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLK 343
             W  VSEE K L+R LL  +P +R+ +       W+   +     PL T  VL+
Sbjct: 638 EAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLE 692



 Score = 85.5 bits (210), Expect = 7e-17
 Identities = 78/277 (28%), Positives = 131/277 (47%), Gaps = 33/277 (11%)

Query: 68  QVLGLGINGKVLQIFNKRTQEK---FALKMLQDCPKARR-EVELHWRAS--------QCP 115
           +VLG G  GKV  +      +    +A+K+L+     +R + + H R          Q P
Sbjct: 37  KVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAP 96

Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175
            +V +   ++        L ++++ + GGE+F+ +  R  Q F E E       I  A++
Sbjct: 97  FLVTLHYAFQT----DAKLHLILDYVSGGEMFTHLYQR--QYFKEAEVRVYGGEIVLALE 150

Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE--TTSHNSLTTPCYTPYYVAPE 233
           +LH + I +RD+K EN+L  S+     + LTDFG +KE  T       + C T  Y+APE
Sbjct: 151 HLHKLGIIYRDLKLENVLLDSE---GHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPE 207

Query: 234 VLGPEK-YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292
           ++  +  + K+ D WSLG++++ LL G  PF           +  RI      FP P   
Sbjct: 208 IIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFP-PRIG 266

Query: 293 EVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPW 324
            V+++   L++ LL  +P +R+        E  NHP+
Sbjct: 267 PVAQD---LLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300


>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
          Length = 729

 Score =  162 bits (409), Expect = 6e-40
 Identities = 106/286 (37%), Positives = 154/286 (53%), Gaps = 24/286 (8%)

Query: 49  KSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH 108
           + G QI    I + YKV  + +G G    V +   + T  ++ALK+++      +E  + 
Sbjct: 377 EEGFQIPAT-ITERYKV-GRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQ 434

Query: 109 WRAS-----QCPHIVRIV---DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 160
              S     + P+IV ++   DV   LY       +VME + GG+LF  I       +TE
Sbjct: 435 NEVSILRRVKHPNIVLLIEEMDVPTELY-------LVMELVKGGDLFDAITSTNK--YTE 485

Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTSHNS 219
           R+AS ++ ++  AI+YLHS+NI HRD+KPENLL Y  +  +  LKL DFG A  T     
Sbjct: 486 RDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLA--TIVDGP 543

Query: 220 LTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI 279
           L T C TP YVAPE++    Y    D+W+ GVI YILLCG+PPF  +        +  +I
Sbjct: 544 LYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGD--DQEVLFDQI 601

Query: 280 RMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325
            MGQ +FP+P W  VS+  K LI  +L  +  QR +  + + HPW+
Sbjct: 602 LMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWV 647


>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
          Length = 586

 Score =  161 bits (408), Expect = 8e-40
 Identities = 107/321 (33%), Positives = 167/321 (52%), Gaps = 42/321 (13%)

Query: 58  AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-----------QDCPKARREVE 106
           A+ D+Y + S+ LG G  G+V   F ++T +K A+K++           +  P    E E
Sbjct: 258 ALRDEY-IMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETE 316

Query: 107 LH-WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165
           +   +    P I++I + ++      +   IV+E ++GGELF ++   G++   E     
Sbjct: 317 IEILKKLNHPCIIKIKNFFD-----AEDYYIVLELMEGGELFDKVV--GNKRLKEATCKL 369

Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY 225
               +  A+QYLH   I HRD+KPEN+L +S+  + ++K+TDFG +K     + + T C 
Sbjct: 370 YFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCG 429

Query: 226 TPYYVAPEVL---GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMG 282
           TP Y+APEVL   G   Y+++ D WSLGVI++I L GYPPF S H   +S  +K +I  G
Sbjct: 430 TPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF-SEHRTQVS--LKDQITSG 486

Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM---------------- 326
           +Y F    W+EVSE+   L++ LL  +P  R T  E + HPW+                 
Sbjct: 487 KYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEEN 546

Query: 327 QSTKVPQTPLHTSRVLKEDKE 347
           +ST +PQ     S   K  +E
Sbjct: 547 ESTALPQVLAQPSTSRKRPRE 567


>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
          Length = 543

 Score =  161 bits (408), Expect = 8e-40
 Identities = 107/321 (33%), Positives = 167/321 (52%), Gaps = 42/321 (13%)

Query: 58  AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-----------QDCPKARREVE 106
           A+ D+Y + S+ LG G  G+V   F ++T +K A+K++           +  P    E E
Sbjct: 215 ALRDEY-IMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETE 273

Query: 107 LH-WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165
           +   +    P I++I + ++      +   IV+E ++GGELF ++   G++   E     
Sbjct: 274 IEILKKLNHPCIIKIKNFFD-----AEDYYIVLELMEGGELFDKVV--GNKRLKEATCKL 326

Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY 225
               +  A+QYLH   I HRD+KPEN+L +S+  + ++K+TDFG +K     + + T C 
Sbjct: 327 YFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCG 386

Query: 226 TPYYVAPEVL---GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMG 282
           TP Y+APEVL   G   Y+++ D WSLGVI++I L GYPPF S H   +S  +K +I  G
Sbjct: 387 TPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF-SEHRTQVS--LKDQITSG 443

Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM---------------- 326
           +Y F    W+EVSE+   L++ LL  +P  R T  E + HPW+                 
Sbjct: 444 KYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEEN 503

Query: 327 QSTKVPQTPLHTSRVLKEDKE 347
           +ST +PQ     S   K  +E
Sbjct: 504 ESTALPQVLAQPSTSRKRPRE 524


>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
          Length = 765

 Score =  161 bits (407), Expect = 1e-39
 Identities = 99/279 (35%), Positives = 153/279 (54%), Gaps = 21/279 (7%)

Query: 55  KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD---CPKAR---REVELH 108
           + + +++ YK+  +V+G G    V +  ++ T ++FALK++     C K      EV + 
Sbjct: 385 ESSTLLEKYKI-GKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSIL 443

Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168
            R    P+I+ +V+  E        L +VME + GG+LF  I       +TER+ S ++ 
Sbjct: 444 RRVKH-PNIIMLVEEMETATE----LFLVMELVKGGDLFDAITS--STKYTERDGSAMVY 496

Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAI--LKLTDFGFAKETTSHNSLTTPCYT 226
           ++  A++YLH ++I HRD+KPENLL   + P+    LKL DFG A  T     L T C T
Sbjct: 497 NLANALRYLHGLSIVHRDIKPENLL-VCEYPDGTKSLKLGDFGLA--TVVEGPLYTVCGT 553

Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286
           P YVAPE++    Y    D+W+ GVI YILLCG+PPF S + L     +  +I  G+ EF
Sbjct: 554 PTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNL--QEDLFDQILAGKLEF 611

Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325
           P P W  +++  K LI  +L+     R T  + ++HPW+
Sbjct: 612 PAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWV 650


>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
          Length = 766

 Score =  161 bits (407), Expect = 1e-39
 Identities = 99/279 (35%), Positives = 153/279 (54%), Gaps = 21/279 (7%)

Query: 55  KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD---CPKAR---REVELH 108
           + + +++ YK+  +V+G G    V +  ++ T ++FALK++     C K      EV + 
Sbjct: 386 ESSTLLEKYKI-GKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSIL 444

Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168
            R    P+I+ +V+  E        L +VME + GG+LF  I       +TER+ S ++ 
Sbjct: 445 RRVKH-PNIIMLVEEMETATE----LFLVMELVKGGDLFDAITS--STKYTERDGSAMVY 497

Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAI--LKLTDFGFAKETTSHNSLTTPCYT 226
           ++  A++YLH ++I HRD+KPENLL   + P+    LKL DFG A  T     L T C T
Sbjct: 498 NLANALRYLHGLSIVHRDIKPENLL-VCEYPDGTKSLKLGDFGLA--TVVEGPLYTVCGT 554

Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286
           P YVAPE++    Y    D+W+ GVI YILLCG+PPF S + L     +  +I  G+ EF
Sbjct: 555 PTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNL--QEDLFDQILAGKLEF 612

Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325
           P P W  +++  K LI  +L+     R T  + ++HPW+
Sbjct: 613 PAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWV 651


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,000,434
Number of Sequences: 37866
Number of extensions: 1059837
Number of successful extensions: 44734
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1455
Number of HSP's successfully gapped in prelim test: 597
Number of HSP's that attempted gapping in prelim test: 15441
Number of HSP's gapped (non-prelim): 16922
length of query: 370
length of database: 18,247,518
effective HSP length: 104
effective length of query: 266
effective length of database: 14,309,454
effective search space: 3806314764
effective search space used: 3806314764
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.