Guide to the Human Genome
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Search of human proteins with 239744982

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239744982 PREDICTED: hypothetical protein [Homo sapiens]
         (627 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239750672 PREDICTED: hypothetical protein [Homo sapiens]          1204   0.0  
gi|239744982 PREDICTED: hypothetical protein [Homo sapiens]          1204   0.0  
gi|239756174 PREDICTED: hypothetical protein [Homo sapiens]          1194   0.0  
gi|148746195 trichohyalin [Homo sapiens]                              101   2e-21
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            91   4e-18
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                    90   7e-18
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    89   2e-17
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    89   2e-17
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    87   5e-17
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    86   8e-17
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...    86   8e-17
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...    86   8e-17
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi...    86   8e-17
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]            81   3e-15
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]            80   4e-15
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        80   4e-15
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        80   4e-15
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         80   4e-15
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         80   4e-15
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         80   4e-15
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         80   4e-15
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         80   4e-15
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         80   4e-15
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]        78   2e-14
gi|224593756 hypothetical protein LOC164127 [Homo sapiens]             77   4e-14
gi|55741709 RNA binding motif protein 25 [Homo sapiens]                77   5e-14
gi|219803769 trichoplein [Homo sapiens]                                74   3e-13
gi|14150056 trichoplein [Homo sapiens]                                 74   3e-13
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti...    73   9e-13
gi|56549694 enabled homolog isoform a [Homo sapiens]                   72   1e-12

>gi|239750672 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 627

 Score = 1204 bits (3114), Expect = 0.0
 Identities = 627/627 (100%), Positives = 627/627 (100%)

Query: 1   MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60
           MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS
Sbjct: 1   MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60

Query: 61  ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120
           ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC
Sbjct: 61  ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120

Query: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL 180
           AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL
Sbjct: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL 180

Query: 181 FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 240
           FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG
Sbjct: 181 FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 240

Query: 241 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 300
           SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST
Sbjct: 241 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 300

Query: 301 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 360
           TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA
Sbjct: 301 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 360

Query: 361 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 420
           LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR
Sbjct: 361 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 420

Query: 421 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 480
           GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ
Sbjct: 421 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 480

Query: 481 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540
           REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ
Sbjct: 481 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540

Query: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 600
           RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE
Sbjct: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 600

Query: 601 KVREETNTRSFDRMVREAQLHASLDRK 627
           KVREETNTRSFDRMVREAQLHASLDRK
Sbjct: 601 KVREETNTRSFDRMVREAQLHASLDRK 627


>gi|239744982 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 627

 Score = 1204 bits (3114), Expect = 0.0
 Identities = 627/627 (100%), Positives = 627/627 (100%)

Query: 1   MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60
           MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS
Sbjct: 1   MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60

Query: 61  ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120
           ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC
Sbjct: 61  ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120

Query: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL 180
           AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL
Sbjct: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL 180

Query: 181 FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 240
           FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG
Sbjct: 181 FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 240

Query: 241 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 300
           SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST
Sbjct: 241 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 300

Query: 301 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 360
           TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA
Sbjct: 301 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 360

Query: 361 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 420
           LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR
Sbjct: 361 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 420

Query: 421 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 480
           GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ
Sbjct: 421 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 480

Query: 481 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540
           REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ
Sbjct: 481 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540

Query: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 600
           RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE
Sbjct: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 600

Query: 601 KVREETNTRSFDRMVREAQLHASLDRK 627
           KVREETNTRSFDRMVREAQLHASLDRK
Sbjct: 601 KVREETNTRSFDRMVREAQLHASLDRK 627


>gi|239756174 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 625

 Score = 1194 bits (3090), Expect = 0.0
 Identities = 624/627 (99%), Positives = 625/627 (99%), Gaps = 2/627 (0%)

Query: 1   MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60
           MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS
Sbjct: 1   MSLLVICRDSNKGRGSAMVDPVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSAS 60

Query: 61  ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120
           ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC
Sbjct: 61  ASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARC 120

Query: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRL 180
           AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAER+RIMREEKRRL
Sbjct: 121 AVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQCRAERDRIMREEKRRL 180

Query: 181 FTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 240
           FTPLSPAAAAAAAAA  SAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG
Sbjct: 181 FTPLSPAAAAAAAAA--SAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAG 238

Query: 241 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 300
           SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST
Sbjct: 239 SRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASST 298

Query: 301 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 360
           TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA
Sbjct: 299 TNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA 358

Query: 361 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 420
           LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR
Sbjct: 359 LMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERR 418

Query: 421 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 480
           GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ
Sbjct: 419 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 478

Query: 481 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540
           REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ
Sbjct: 479 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 538

Query: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 600
           RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE
Sbjct: 539 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 598

Query: 601 KVREETNTRSFDRMVREAQLHASLDRK 627
           KVREETNTRSFDRMVREAQLHASLDRK
Sbjct: 599 KVREETNTRSFDRMVREAQLHASLDRK 625


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  101 bits (251), Expect = 2e-21
 Identities = 83/266 (31%), Positives = 134/266 (50%), Gaps = 21/266 (7%)

Query: 353  ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRR-A 411
            ER R+   L      +E L  EQ+     + ELQR         EEREK+R  EQ R+  
Sbjct: 881  ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQR---------EEREKRRRQEQERQYR 931

Query: 412  WAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRK 471
               Q+++   +  REERE  RR++R  ER   + ++L +++  L  E  E+  R++R +K
Sbjct: 932  EEEQLQQEEEQLLREEREKRRRQER--ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989

Query: 472  LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEA 531
             ++E+ L+Q EE L   RE  E+ RR+  +R    + R++ +LQ+E+ +L R ER +   
Sbjct: 990  YREEEELQQEEEQLL--REEREKRRRQEWER----QYRKKDELQQEEEQLLREEREKRR- 1042

Query: 532  LLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARST 591
             LQ R RQ R+E E L+   E  LG  +E      + R+  + E+L +E    L      
Sbjct: 1043 -LQERERQYREEEE-LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100

Query: 592  ARASFHVREKVREETNTRSFDRMVRE 617
             R     R+   EE   +  ++++RE
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLRE 1126



 Score = 99.8 bits (247), Expect = 7e-21
 Identities = 85/283 (30%), Positives = 136/283 (48%), Gaps = 29/283 (10%)

Query: 343  RAERGLRGVPERDRKIAAL-MLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREK 401
            R ERG +   +RDRK      L + +EE  L  Q      + E Q+V  +Q +ER+  E 
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVR-RQEQERKFMED 1600

Query: 402  QRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAE 461
            ++ L   R+    Q+ + R R+ RE+ +  + R+ Q    +ER R+  E +  LRR+  E
Sbjct: 1601 EQQLR--RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE 1658

Query: 462  RAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKREL 521
            +  R DR RK ++E+ L      LQEG E  +Q+RR+   R  R +++Q  + +RE++ L
Sbjct: 1659 QQLRHDRDRKFREEEQL------LQEGEE--QQLRRQERDRKFREEEQQLRRQERERKFL 1710

Query: 522  SRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRER 581
               ++ R + L      ++ +E E LR   E    R QE Y      RK+   EQL R  
Sbjct: 1711 QEEQQLRRQEL-----ERKFREEEQLRQETEQEQLRRQERY------RKILEEEQL-RPE 1758

Query: 582  RSALESARSTARASFHVREKVREE-----TNTRSFDRMVREAQ 619
            R   +  R      F   E++R+E       ++  DR  RE +
Sbjct: 1759 REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEE 1801



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 91/323 (28%), Positives = 150/323 (46%), Gaps = 40/323 (12%)

Query: 325  LSHSPQTAQHVERIVR-QVRAERGLRGVPERDRKIAALMLARHQE-ELLLLEQRAAAHGQ 382
            LS  P   +  ER +R + R +R  R +PE + K       R +E EL  LE+      +
Sbjct: 784  LSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRR 843

Query: 383  WELQRVHAKQRREREEREKQRALEQGR-RAWAAQVEERRGRRG----------------- 424
               Q++  ++   +E++E++R+ EQ R + W  Q+EE R RR                  
Sbjct: 844  ERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903

Query: 425  ---REEREAARRRQRQYERSEERRRELAERQGL------LRRERAERAAREDRLRKLQQE 475
               +EE E  +R +R+  R +E+ R+  E + L      L RE  E+  R++R R+ +++
Sbjct: 904  QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963

Query: 476  QNLKQREEGLQ-EGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQ 534
            + L+Q+EE L  E  E+  +  RE+  R     Q++E QL RE+RE    +R R E   Q
Sbjct: 964  KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE----KRRRQEWERQ 1019

Query: 535  GRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARA 594
             R + + Q+ E      E    R QE        R+    E+L +E    L   R T R 
Sbjct: 1020 YRKKDELQQEEEQLLREEREKRRLQERE------RQYREEEELQQEEEQLLGEERETRRR 1073

Query: 595  SFHVREKVREETNTRSFDRMVRE 617
                R+  +EE   +  ++++RE
Sbjct: 1074 QELERQYRKEEELQQEEEQLLRE 1096



 Score = 96.7 bits (239), Expect = 6e-20
 Identities = 87/297 (29%), Positives = 145/297 (48%), Gaps = 19/297 (6%)

Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLE---QRAAAHGQWELQRVHAKQ-RRE 395
           R+ R +R  +   E++ +    +L + +E+L   E   QR     + +L+++  ++ RRE
Sbjct: 230 RRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289

Query: 396 REEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEER-RRELAERQGL 454
           R+E E+Q+   +  +    + EE R  +  E RE   RR++Q ER E++ RRE  ER+  
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQ 349

Query: 455 LRRERAERAAREDRLRKLQQEQNLKQ---REEGLQEGRE--RAEQIRRE----RAQRAAR 505
             R   E   RE +LR+ Q+E+  +Q   RE+ L+  ++  R +Q+RRE    R Q+  R
Sbjct: 350 QLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 409

Query: 506 AKQ-RQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEH 564
            +Q R+E QL+RE++     E  RHE   +   R+QR +RE  +      L R +E   H
Sbjct: 410 EQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE--QEERRDWLKREEETERH 467

Query: 565 LAIGRKLERSEQLTRERRSALESARSTARASFHVR--EKVREETNTRSFDRMVREAQ 619
               RK +       ERR          R     R  +++R E   R   R+ R+ +
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEE 524



 Score = 96.7 bits (239), Expect = 6e-20
 Identities = 91/322 (28%), Positives = 148/322 (45%), Gaps = 28/322 (8%)

Query: 318  RSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRA 377
            R F   +L H  Q  + +E   R  R ER  + + E  +    L     +++L     R 
Sbjct: 1360 RKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ----LRCQEREQQLRQDRDRK 1415

Query: 378  AAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAA--QVEERRGRRGREEREAARRRQ 435
                + +L R   + R+ REE ++ R  E+ R+      Q+ + R R+ REE +  + R+
Sbjct: 1416 FREEEQQLSR-QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQERE 1474

Query: 436  RQYERSEERRRELAERQGLLRRERAERAAREDRLRK-------LQQEQNL---KQREEGL 485
             Q    +ER R+  E +  LRR+  +R  RE  LR        L++EQ L   +++ + L
Sbjct: 1475 EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFL 1534

Query: 486  QEGRERAEQIRRERAQRAARAKQRQEGQL--QREKRELSRAERARHEALLQGRTRQQRQE 543
            QE ++   Q R ++ ++    K R+E QL  +RE+++LSR ER R   L + + R+Q QE
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQE 1594

Query: 544  REGLRSSLEASLGRAQENYEHL--AIGRKLERSEQLTRERRS----ALESARSTARASFH 597
            R+ +    +    R QE  + L     RK    EQL +ER        E  R        
Sbjct: 1595 RKFMEDEQQL---RRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQ 1651

Query: 598  VREKVREETNTRSFDRMVREAQ 619
            +R + RE+      DR  RE +
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEE 1673



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 81/301 (26%), Positives = 136/301 (45%), Gaps = 23/301 (7%)

Query: 345 ERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQW-----ELQRVHAKQRREREER 399
           +R L+   E+ RK+    L R ++E    +QR     Q      E +R   ++RRE++ER
Sbjct: 268 QRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER 327

Query: 400 EKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRE- 458
            +Q+   + ++    Q E R  +  RE+ E  R +Q + E+ EERR +   R+  LRRE 
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387

Query: 459 ---------RAERAAREDRLRKLQQ---EQNLKQREEGLQEGRERAEQIRRERAQRAARA 506
                    R ++  RE +LR+ QQ   EQ L++ ++  +E  E   + + E+ +R  R 
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447

Query: 507 KQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLA 566
           K+ QE +    KRE    ER   E   Q   R Q +ER      LE    R Q+      
Sbjct: 448 KREQEERRDWLKRE-EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERRE-- 504

Query: 567 IGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDR 626
             ++L R ++  RE+R   +      +      +++R E   R    + RE +     +R
Sbjct: 505 --QQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562

Query: 627 K 627
           +
Sbjct: 563 R 563



 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 82/286 (28%), Positives = 142/286 (49%), Gaps = 21/286 (7%)

Query: 343  RAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRER------ 396
            R ER  R   E++R+       + +EE LL E+R     Q E +R + K ++ +      
Sbjct: 915  REEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ-ERERQYRKDKKLQQKEEQL 973

Query: 397  --EEREKQRALEQGRR-AWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
              EE EK+R  E+ ++     ++++   +  REERE  +RR++++ER   ++ EL + + 
Sbjct: 974  LGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE--KRRRQEWERQYRKKDELQQEEE 1031

Query: 454  LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
             L RE  E+   ++R R+ ++E+ L+Q EE L  G ER E  RR+  +R    + R+E +
Sbjct: 1032 QLLREEREKRRLQERERQYREEEELQQEEEQLL-GEER-ETRRRQELER----QYRKEEE 1085

Query: 514  LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
            LQ+E+ +L R E  +     Q R RQ R+E E L+   E  L   +E      + R+   
Sbjct: 1086 LQQEEEQLLREEPEKRRR--QERERQCREEEE-LQQEEEQLLREEREKRRRQELERQYRE 1142

Query: 574  SEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQ 619
             E++ +E    L       R     R+   EE   +  ++++RE Q
Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 78/306 (25%), Positives = 140/306 (45%), Gaps = 26/306 (8%)

Query: 336 ERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRE 395
           E +++  R E   R    RDR++      R +++    ++R  A G+ + ++    ++R+
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQE-QERELAEGEEQSEKQERLEQRD 165

Query: 396 REERE----KQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAER 451
           R+ R+    +QR   Q R    A+ E+ +  +G E  E     Q +     E RR+  E 
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE 225

Query: 452 QGLLRRERAERAAREDRLR--------------KLQQEQNLKQREEGLQEGRERAEQIRR 497
           +   RRER +R  +E+  +              KLQ+E+  +QRE  LQE  E+  ++ R
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE--LQEEEEQLRKLER 283

Query: 498 ERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGR 557
           +  +R  + +++Q+ +L+RE++   + E  R E   Q   R+Q++ RE      E  L R
Sbjct: 284 QELRRERQEEEQQQQRLRREQQLRRKQEEERREQ--QEERREQQERREQQEERREQQLRR 341

Query: 558 AQENYEHLAIGRKLE---RSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRM 614
            QE      + R+ E   R +QL RE+       +          +++R E   R   ++
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL 401

Query: 615 VREAQL 620
            RE QL
Sbjct: 402 RREQQL 407



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 86/300 (28%), Positives = 140/300 (46%), Gaps = 26/300 (8%)

Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELL-LLEQRAAAHGQWELQRVHAKQRREREE 398
           RQ+  E G R   +R  +   L     Q E    LEQR       EL R    QR+E +E
Sbjct: 127 RQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWR----QRQEWQE 182

Query: 399 REKQRALEQ------GRRAWAAQVEERRGRR--------GREEREAARRRQRQYERSEER 444
           RE++RA E+      G        EE+  RR        GREE++  RR ++     EE 
Sbjct: 183 REERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEE 242

Query: 445 RRELAERQGLLRRERAERAARE-DRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRA 503
            +E  +R+ +LR+E  +    E  R R+LQ+E+   ++ E  +  RER E+ ++++  R 
Sbjct: 243 EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR 302

Query: 504 ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQE--- 560
            +  +R++ + +RE++E  R ++ R E   + R +Q R+E+E  R   E  L R QE   
Sbjct: 303 EQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR---EQQLRREQEEER 359

Query: 561 NYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQL 620
             + L   ++ ER EQ  R  +      +          +++R E   R   ++ RE QL
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 84/284 (29%), Positives = 139/284 (48%), Gaps = 36/284 (12%)

Query: 340 RQVRAERGLRGVPERDR-------KIAALMLARHQEEL---LLLEQRAAAHGQ----WEL 385
           +Q+R E+ LR   E +R       +     L R QEE    L  E+    H Q     +L
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476

Query: 386 QRVHAKQRRER----EEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERS 441
           +R   ++RRER    EE E++   E+  +    + EERR +R + + E  R +QR     
Sbjct: 477 KRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ 536

Query: 442 EERRRELAERQGLLRRE---RAERAAREDRLRKLQQE---QNLKQREEGLQ-----EGRE 490
           + RR +   R+ LL+RE   R E+  RE RL++ Q+E   Q LK+ EE  Q     E  E
Sbjct: 537 QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE 596

Query: 491 RAEQ-IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRS 549
           R EQ ++RE  +R  + ++R+E +L+RE+      E  R + LL+   +++R++++  R 
Sbjct: 597 RLEQRLKREEVERLEQ-EERREQRLKREE-----PEEERRQQLLKSEEQEERRQQQLRRE 650

Query: 550 SLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTAR 593
             E    R +   E   + ++L+R  +  R  +   E  +  AR
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694



 Score = 89.7 bits (221), Expect = 7e-18
 Identities = 86/293 (29%), Positives = 147/293 (50%), Gaps = 34/293 (11%)

Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRE---- 395
           +Q+R E+ LR    R++++      R +++L   +Q      +   ++ H ++RRE    
Sbjct: 393 QQLRREQQLR----REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLK 448

Query: 396 REEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLL 455
           RE+ E++  L++       + E R+ +  R++ E  R R  + E  EERR +   R+  L
Sbjct: 449 REQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLE-EEERREQQERREQQL 507

Query: 456 RRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAAR-AKQRQEGQL 514
           RRE+ ER  RE RL++ ++E+ L+QR    Q       Q+RRE+ +R  +  K+ +E +L
Sbjct: 508 RREQEER--REQRLKRQEEEERLQQRLRSEQ-------QLRREQEERREQLLKREEEKRL 558

Query: 515 QREKRE--LSRAERARHEALL--QGRTRQQRQEREGLRSSLEASLGRAQENYEHL----A 566
           ++E+RE  L R +  R + LL  +   RQQR +RE     LE  L R  E  E L     
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEERRQQRLKRE-QEERLEQRLKR--EEVERLEQEER 615

Query: 567 IGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQ 619
             ++L+R E     R+  L+S     R     ++++R E   R   R+ RE +
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERR----QQQLRREQQERREQRLKREEE 664



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 72/236 (30%), Positives = 122/236 (51%), Gaps = 22/236 (9%)

Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
           +QRRER++R  Q   E+  + W  +    R +   + +E   +RQR+ +  EE+ R+L  
Sbjct: 228 QQRRERQDRVFQ---EEEEKEWRKRETVLR-KEEEKLQEEEPQRQRELQEEEEQLRKLER 283

Query: 451 RQGLLRRERAE------RAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAA 504
           ++  LRRER E      R  RE +LR+ Q+E+  +Q+EE  ++   R +Q  R   Q   
Sbjct: 284 QE--LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR 341

Query: 505 RAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEH 564
             ++R+E QL+RE+ E  R ++ R E   + R +Q R+E++  R   E  L R Q+    
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR---EQQLRREQQ---- 394

Query: 565 LAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQL 620
           L   ++L R +QL RE++   E      R    +R +  EE + +  ++  RE +L
Sbjct: 395 LRREQQLRREQQLRREQQLRRE---QQLRREQQLRREQEEERHEQKHEQERREQRL 447



 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 88/307 (28%), Positives = 143/307 (46%), Gaps = 39/307 (12%)

Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
           +Q+R E+ LR    R++++      R +++L   ++      + E +R   + +RE+EER
Sbjct: 399 QQLRREQQLR----REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEER 454

Query: 400 -------EKQRALEQGRRAWAAQVEERRGRRGR-------EEREAARRRQRQYERSEERR 445
                  E+    EQ RR    + ++   RR R       E RE   RR++Q  R +E R
Sbjct: 455 RDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER 514

Query: 446 RELAERQGLLRRERAERAAR----EDRLRKLQQ---EQNLKQREEGLQEGRERAEQIRRE 498
           RE    Q L R+E  ER  +    E +LR+ Q+   EQ LK+ EE   E   R ++++RE
Sbjct: 515 RE----QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570

Query: 499 RAQR----AARAKQRQEGQLQREKREL--SRAERARHEALLQGRTRQQRQEREGLRSSLE 552
           + +R      R ++R++ +L+RE+ E    R +R   E L Q   R+QR +RE       
Sbjct: 571 QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERR 630

Query: 553 ASLGRAQENYEHLAIGRKLERSEQLTRERR--SALESARSTARASFHVREKVREETNTRS 610
             L +++E  E     ++L R +Q  RE+R     E  R   R      E+ RE+     
Sbjct: 631 QQLLKSEEQEERRQ--QQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE 688

Query: 611 FDRMVRE 617
                RE
Sbjct: 689 EQEQARE 695



 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 88/315 (27%), Positives = 147/315 (46%), Gaps = 35/315 (11%)

Query: 333 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQ 392
           Q   R  ++ R E+ LR   E  R+     L R QEE    E+R     + +L+R   ++
Sbjct: 324 QQERREQQEERREQQLRREQEERRE---QQLRREQEE----ERR-----EQQLRREQEEE 371

Query: 393 RREREEREKQ--RALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
           RRE++ R +Q  R  +Q RR    + E++  R  +  RE   RR++Q  R ++ RRE  E
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE 431

Query: 451 RQGLLRRERAERAAREDRLRKLQQEQN--LKQREEGLQEGRER--------AEQIRRER- 499
            +     ++ E+  RE RL++ Q+E+   LK+ EE  +  +ER         E+ RRER 
Sbjct: 432 ER---HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488

Query: 500 ----AQRAARAKQRQEGQLQREKREL--SRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
                +     ++R+E QL+RE+ E    R +R   E  LQ R R ++Q R       E 
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548

Query: 554 SLGRAQE-NYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFD 612
            L R +E   E     ++L+R ++  R++    E  R   R      E++ +       +
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608

Query: 613 RMVREAQLHASLDRK 627
           R+ +E +    L R+
Sbjct: 609 RLEQEERREQRLKRE 623



 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 92/309 (29%), Positives = 154/309 (49%), Gaps = 37/309 (11%)

Query: 333  QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAK- 391
            Q  E+++R+ R +R L+   ER+R+       + +EE LL E+R     Q EL+R + K 
Sbjct: 1028 QEEEQLLREEREKRRLQ---ERERQYREEEELQQEEEQLLGEERETRRRQ-ELERQYRKE 1083

Query: 392  ---QRRE----REEREKQRALEQGRRA-WAAQVEERRGRRGREEREAARRRQRQYERSEE 443
               Q+ E    REE EK+R  E+ R+     ++++   +  REERE  +RR+++ ER   
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE--KRRRQELERQYR 1141

Query: 444  RRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRA 503
               E+ + +  L RE  E+  R++  R+ ++E+ L+Q EE L   RE  E+ R+ER +  
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL--REEQEKRRQERER-- 1197

Query: 504  ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQERE-GLRSSLEASLGRAQENY 562
               + R+E +LQR+KR+    +R R E        Q   E+E  +R +     GR  E +
Sbjct: 1198 ---QYREEEELQRQKRK----QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQF 1250

Query: 563  EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSF---DRMVREAQ 619
                  R+LE S+   R+ +  L+      +     +E+ R +   R F   +++ RE Q
Sbjct: 1251 ------RQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304

Query: 620  LHAS-LDRK 627
              A   DRK
Sbjct: 1305 KEAKRRDRK 1313



 Score = 86.3 bits (212), Expect = 8e-17
 Identities = 84/305 (27%), Positives = 139/305 (45%), Gaps = 26/305 (8%)

Query: 330  QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 389
            Q  Q  E+++R+ R +R  +   ER+R+       + +EE LL E+      Q   ++  
Sbjct: 935  QLQQEEEQLLREEREKRRRQ---ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991

Query: 390  AKQRRE-------REEREKQRALE---QGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
             ++  +       REEREK+R  E   Q R+    Q EE +  R   E+   + R+RQY 
Sbjct: 992  EEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYR 1051

Query: 440  RSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRER 499
              EE ++E    + LL  ER  R  R++  R+ ++E+ L+Q EE L   RE  E+ RR+ 
Sbjct: 1052 EEEELQQE---EEQLLGEERETRR-RQELERQYRKEEELQQEEEQLL--REEPEKRRRQE 1105

Query: 500  AQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQ 559
             +R  R    +E +LQ+E+ +L R ER +     Q   RQ R+E E ++   E  L    
Sbjct: 1106 RERQCR----EEEELQQEEEQLLREEREKRRR--QELERQYREEEE-VQQEEEQLLREEP 1158

Query: 560  ENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQ 619
            E      + R+    E+L +E    L   +   R     + +  EE   +   +  R+  
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218

Query: 620  LHASL 624
              + L
Sbjct: 1219 QRSDL 1223



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 78/300 (26%), Positives = 141/300 (47%), Gaps = 32/300 (10%)

Query: 333 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQ 392
           Q  ER  +Q+R E+ LR    R++++      R +++L   +Q          Q++  +Q
Sbjct: 368 QEEERREQQLRREQQLR----REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 423

Query: 393 --RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
             RRE+EE   ++  EQ RR       E+R +R +EER    +R+ + ER E+ RR    
Sbjct: 424 QLRREQEEERHEQKHEQERR-------EQRLKREQEERRDWLKREEETERHEQERR---- 472

Query: 451 RQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRE--RAEQIRRERAQRAARAKQ 508
           +Q L R +  ER  R  +L + ++ +  ++RE+ L+  +E  R ++++R+  +   + + 
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL 532

Query: 509 RQEGQLQREKREL-SRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAI 567
           R E QL+RE+ E   +  +   E  L+   R+QR +RE             +E  + L  
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE------------QEERRDQLLK 580

Query: 568 GRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
             +  R ++L RE+   LE            +E+ RE+   R      R  QL  S +++
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 80/302 (26%), Positives = 142/302 (47%), Gaps = 39/302 (12%)

Query: 340  RQVRAERGLRGV-PERDRKIAA---LMLARHQEELLLLEQ-RAAAHGQWELQRVHAKQR- 393
            +Q+R + G + +  ERDRK      L+  R +++L   E+ R     + +L+R   +Q+ 
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661

Query: 394  ---REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE----------- 439
               R+R+ RE+++ L++G      + E  R R+ REE +  RR++R+ +           
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQE--RDRKFREEEQQLRRQERERKFLQEEQQLRRQ 1719

Query: 440  ------RSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
                  R EE+ R+  E++ L R+ER  +   E++LR  ++EQ L+++E   +   E  E
Sbjct: 1720 ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREE--E 1777

Query: 494  QIRRERAQRAARAKQ-----RQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLR 548
            Q+R+ER ++  R+++     R+E QL++E+ E     + R         + Q +E+E   
Sbjct: 1778 QLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQE--- 1834

Query: 549  SSLEASLGRAQENYEHLAIGRKLERSEQ-LTRERRSALESARSTARASFHVREKVREETN 607
              L     R     E  A   K  R EQ L +E        R       H+R + +EE  
Sbjct: 1835 QRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894

Query: 608  TR 609
             R
Sbjct: 1895 HR 1896



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 78/312 (25%), Positives = 139/312 (44%), Gaps = 30/312 (9%)

Query: 328  SPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQR 387
            S Q  QH+    ++   E+  R   +RDR          +E+L   EQ+ A     + Q 
Sbjct: 1263 SQQDLQHLLGEQQERDREQERRRWQQRDRHFP------EEEQLEREEQKEAKRRDRKSQE 1316

Query: 388  VHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
                 R EREE+ +++  ++  R      EE +  + REE+   R+ + +  R EE R +
Sbjct: 1317 EKQLLREEREEKRRRQETDRKFR------EEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370

Query: 448  LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRER-----AEQIRRERAQR 502
               R+ L   +R  R  RE +  K +Q+   ++RE+ L++ R+R      +Q+ R+   R
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430

Query: 503  AARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENY 562
              R +++Q  + +RE++ L   ++ R E     R R+ R+E + L+   E  L R + + 
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQE-----RHRKFREEEQLLQEREEQQLHRQERDR 1485

Query: 563  EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSF-------DRMV 615
            + L   ++L R E+  + R   L S +   R      +++  +   R F        R  
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRS-QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544

Query: 616  REAQLHASLDRK 627
            R  Q     DRK
Sbjct: 1545 RGQQRRQDRDRK 1556



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 83/325 (25%), Positives = 144/325 (44%), Gaps = 65/325 (20%)

Query: 351  VPERDRKIAALMLARHQEELLLLEQRAAAHGQW-ELQRVHAKQRREREERE------KQR 403
            V  R RK       + QEE     +R  +  QW E +R H +Q+ E + R+       + 
Sbjct: 719  VYSRPRKQEGQRRRQEQEEK---RRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEE 775

Query: 404  ALEQGRRAWAAQ--VEERRGRRGREEREAARRRQR---QYERSEERRRELAERQGLLR-R 457
              E+GR+  +A+  + E+R R+ R E E  +R QR   + E  E+RRR+  ER+  L+  
Sbjct: 776  KSERGRQRLSARPPLREQRERQLRAE-ERQQREQRFLPEEEEKEQRRRQRREREKELQFL 834

Query: 458  ERAERAAREDRLRKLQQEQN---------------------------------------- 477
            E  E+  R +R ++LQ+E++                                        
Sbjct: 835  EEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA 894

Query: 478  ----LKQREEGLQEGRERAEQIRRERAQRAARAKQ-RQEGQLQREKRELSRAERARHEAL 532
                L++ ++ LQE  E  ++  RE+ +R  + +Q R+E QLQ+E+ +L R ER +    
Sbjct: 895  LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR- 953

Query: 533  LQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTA 592
             Q R RQ R++++ L+   E  LG   E        +K    E+L +E    L   R   
Sbjct: 954  -QERERQYRKDKK-LQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011

Query: 593  RASFHVREKVREETNTRSFDRMVRE 617
            R     R+  +++   +  ++++RE
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLRE 1036



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 82/326 (25%), Positives = 147/326 (45%), Gaps = 34/326 (10%)

Query: 324  DLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQW 383
            D +   Q  +  ER  +++ A   LR   +R+R++ A       EE    EQR     + 
Sbjct: 766  DFTWQWQAEEKSERGRQRLSARPPLR--EQRERQLRA-------EERQQREQRFLPEEEE 816

Query: 384  ELQRVHAKQRREREER----EKQRALEQGRRAWAAQVEE------RRGRRGREEREAARR 433
            + QR   +QRRERE+     E++  L++  RA   Q EE      +  RR +E+R   + 
Sbjct: 817  KEQR--RRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874

Query: 434  RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
            R +  E  + RR  L  +  L  + R E+   ++   +LQ+E+  K+R +  +      E
Sbjct: 875  RWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE 934

Query: 494  QIRRE-----RAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ----ER 544
            Q+++E     R +R  R +Q +E Q +++K+   + E+   E   + R RQ+R+    E 
Sbjct: 935  QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE-PEKRRRQEREKKYREE 993

Query: 545  EGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
            E L+   E  L   +E        R+  + ++L +E    L   R   R     R+   E
Sbjct: 994  EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE 1053

Query: 605  ETNTRSFDRMV---REAQLHASLDRK 627
            E   +  ++++   RE +    L+R+
Sbjct: 1054 EELQQEEEQLLGEERETRRRQELERQ 1079



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 76/262 (29%), Positives = 121/262 (46%), Gaps = 23/262 (8%)

Query: 374 EQRAAAHGQWEL--QRVHAKQRREREEREKQRALEQG-RRAWAAQVEERRGRRGREEREA 430
           E+RA   G+  L   R   + +R  E R++Q   E G RR    Q +ER    G E+ E 
Sbjct: 98  EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE- 156

Query: 431 ARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLR--------KLQQEQNLKQRE 482
             +++R  +R  +RR E   RQ    +ER ER A E++L+        +   E+ L++RE
Sbjct: 157 --KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214

Query: 483 --EGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540
             E  ++GRE  +Q RRER  R  + ++ +E    R++  + R E  + +     R R+ 
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKE---WRKRETVLRKEEEKLQEEEPQRQREL 271

Query: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVRE 600
           ++E E LR      L R ++  E     ++L R +QL R++       +   R     RE
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQ--QRLRREQQLRRKQEEERREQQEERREQQERRE 329

Query: 601 --KVREETNTRSFDRMVREAQL 620
             + R E   R      RE QL
Sbjct: 330 QQEERREQQLRREQEERREQQL 351



 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 77/265 (29%), Positives = 123/265 (46%), Gaps = 25/265 (9%)

Query: 325 LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
           L    +T +H      Q R ++ L+   E +R+   L L   +       +      + E
Sbjct: 458 LKREEETERH-----EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE 512

Query: 385 LQRVHAKQRREREEREKQR--ALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
            +R    +R+E EER +QR  + +Q RR    + E+   R   +  E  RR QR     E
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE 572

Query: 443 ERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQR 502
           ERR +L +R+   R++R +R  +E+RL     EQ LK+ E    E  ER EQ    R +R
Sbjct: 573 ERRDQLLKREEERRQQRLKR-EQEERL-----EQRLKREEVERLEQEERREQ----RLKR 622

Query: 503 AARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENY 562
               ++R++  L+ E++E  R ++ R E   Q   R+QR +RE     LE  L R     
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRRE---QQERREQRLKREEEEERLEQRLKR----- 674

Query: 563 EHLAIGRKLERSEQLTRERRSALES 587
           EH    R+ E +E+   + R  ++S
Sbjct: 675 EHEEERREQELAEEEQEQARERIKS 699



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 90/344 (26%), Positives = 147/344 (42%), Gaps = 61/344 (17%)

Query: 333 QHVERIVRQVRAERGL-RGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAK 391
           + VER+ ++ R E+ L R  PE +R+   L+ +  QEE    + R     + E QR+  +
Sbjct: 605 EEVERLEQEERREQRLKREEPEEERR-QQLLKSEEQEERRQQQLRREQQERRE-QRLKRE 662

Query: 392 QRREREEREKQRALEQGRRAWAAQVEERRGRRGRE-----------EREAARRRQRQYER 440
           +  ER E+  +R  E+ RR      EE+   R R            E EA  R+ + Y R
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR 722

Query: 441 ---SEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLK-------QREEGLQEGRE 490
               E +RR   + +   RRE   +   E+R  + QQE+  +       Q EE  + GR+
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782

Query: 491 R--AEQIRRERAQRAARAKQRQEGQL-------QREKRELSRAERARH------EALLQG 535
           R  A    RE+ +R  RA++RQ+ +        ++E+R   R ER +       E  LQ 
Sbjct: 783 RLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR 842

Query: 536 RTRQQR--QEREGLRSSLEASLGRAQEN-------------------YEHLAIGRKLERS 574
           R R Q+  +E +GL+   E    + Q                     Y   A+  +L + 
Sbjct: 843 RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE 902

Query: 575 EQLTRERRSALE-SARSTARASFHVREKVREETNTRSFDRMVRE 617
           +QL +E    L+   R   R     R+   EE   +  ++++RE
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE 946



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 86/313 (27%), Positives = 137/313 (43%), Gaps = 33/313 (10%)

Query: 336 ERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQW---------ELQ 386
           ER  +Q R E+ LR   E  R+       + QEE   L+QR  +  Q          +L 
Sbjct: 495 ERREQQERREQQLRREQEERRE----QRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550

Query: 387 RVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRR 446
           +   ++R E+E RE++   EQ  R       E   R+ R +RE   R +++ +R E  R 
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610

Query: 447 ELAE-RQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAAR 505
           E  E R+  L+RE  E   R+  L+  +QE+  +++++  +E +ER EQ R +R +   R
Sbjct: 611 EQEERREQRLKREEPEEERRQQLLKSEEQEE--RRQQQLRREQQERREQ-RLKREEEEER 667

Query: 506 AKQRQEGQLQREKRELSRAERARHEALLQGRTR-----QQRQEREGLRSSLEASLGRAQE 560
            +QR + + + E+RE   AE  + +A  + ++R      Q +     R S   S  R QE
Sbjct: 668 LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727

Query: 561 ----NYEHLAIGRKLERSEQLTRERRSALESARSTARASF-------HVREKVREETNTR 609
                 E     R+ E   Q   E R+  +      R  F          E+ R+  + R
Sbjct: 728 GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR 787

Query: 610 SFDRMVREAQLHA 622
              R  RE QL A
Sbjct: 788 PPLREQRERQLRA 800



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 91/346 (26%), Positives = 153/346 (44%), Gaps = 64/346 (18%)

Query: 330  QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQ---RAAAHGQW--- 383
            +  Q  E+++R+   +R  + +  + R+   L   + +E+LL  EQ   R     Q+   
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQ--QEEEQLLREEQEKRRQERERQYREE 1202

Query: 384  -ELQRVHAKQR-REREER---------EKQRAL------------EQGRRAWAAQVEERR 420
             ELQR   KQR R+ ++R         EK+ A+            EQ R+   +Q+ +R+
Sbjct: 1203 EELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ 1262

Query: 421  ---------GRRGREEREAARRR----------QRQYERSEE-----RRRELAERQGLLR 456
                     G +   +RE  RRR          + Q ER E+     R R+  E + LLR
Sbjct: 1263 SQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLR 1322

Query: 457  RERAERAAREDRLRKL-QQEQNLKQREEGLQEGRERAEQIRRE--RAQRAARAKQRQEGQ 513
             ER E+  R++  RK  ++EQ L++REE     +ER  + R E  R Q   R    +E +
Sbjct: 1323 EEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQR 1382

Query: 514  LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
            L+R++RE  +  +   +   Q R +Q RQ+R+      E  L R + + +     +++ R
Sbjct: 1383 LRRQERE-RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441

Query: 574  SEQLTRERRSALE--SARSTARASFHVREKVREETNTRSFDRMVRE 617
             E   RER+   E    R      F   E++ +E   +   R  R+
Sbjct: 1442 QE---RERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERD 1484



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 78/266 (29%), Positives = 123/266 (46%), Gaps = 30/266 (11%)

Query: 325  LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA--LMLARHQEELLLLEQRAAAHGQ 382
            L H        E  + Q   E+ LR   ERDRK       L R + E   L++      Q
Sbjct: 1661 LRHDRDRKFREEEQLLQEGEEQQLRR-QERDRKFREEEQQLRRQERERKFLQEEQQLRRQ 1719

Query: 383  WELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
             EL+R   ++ + R+E E+++   Q R  +   +EE + R  REE++  R+ + +  R E
Sbjct: 1720 -ELERKFREEEQLRQETEQEQLRRQER--YRKILEEEQLRPEREEQQLRRQERDRKFREE 1776

Query: 443  ERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQR---------EEGLQ----EGR 489
            E+ R+  E Q L  +E   +   E++LR+ ++EQ L+ +         EE LQ    E R
Sbjct: 1777 EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQR 1836

Query: 490  ---ERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREG 546
               ER  Q R E         +R+E +L +E+ +  R ER R   L +   R+Q++E + 
Sbjct: 1837 LRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERER--KLREEHIRRQQKEEQR 1894

Query: 547  LRSSLEASLGRAQENYEHLAIGRKLE 572
             R   E    ++QE   H   GR LE
Sbjct: 1895 HRQVGEI---KSQEGKGH---GRLLE 1914



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 67/245 (27%), Positives = 100/245 (40%), Gaps = 40/245 (16%)

Query: 417 EERRGR-RGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAR---------- 465
           EE+R R  G+E     RR++    R E R R+L E  G  RR++ +   R          
Sbjct: 97  EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156

Query: 466 -----EDRLRKLQQEQNLKQREEGLQEGRERAEQIR------------------RERAQR 502
                E R R+ + E+  +QR+E  +    RAE+ +                  R R   
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELL 216

Query: 503 AARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENY 562
             R K R+E Q QR +R+  R  +   E   + R    R+E E L+          QE  
Sbjct: 217 ELRRKGREEKQQQRRERQ-DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275

Query: 563 EHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHA 622
           E L   RKLER E L RER+   E  +   R    +R K  EE   +  +R  ++ +   
Sbjct: 276 EQL---RKLERQE-LRRERQEE-EQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330

Query: 623 SLDRK 627
             +R+
Sbjct: 331 QEERR 335



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 50/190 (26%), Positives = 84/190 (44%), Gaps = 17/190 (8%)

Query: 448 LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
           L +  GL   +RA    +E  L+  +QE++ ++ E   ++  E   Q RR++ Q   R  
Sbjct: 89  LGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQEREL 148

Query: 508 QRQEGQLQREKRELSRAERARHEALLQGRTR-QQRQEREGLRSSLEASLGRAQENY---- 562
              E Q ++++R   R  + R E L + R   Q+R+ER      L++  G   E +    
Sbjct: 149 AEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEE 208

Query: 563 -----EHLAIGRK-LERSEQLTRERRSAL---ESARSTARASFHVR---EKVREETNTRS 610
                E L + RK  E  +Q  RER+  +   E  +   +    +R   EK++EE   R 
Sbjct: 209 QLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268

Query: 611 FDRMVREAQL 620
            +    E QL
Sbjct: 269 RELQEEEEQL 278


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 68/211 (32%), Positives = 120/211 (56%), Gaps = 26/211 (12%)

Query: 381 GQWELQRVHAKQRRERE----EREKQRALEQGRRAWAAQVEERRGRRGREEREAA-RRRQ 435
           G+ E +    K+RRERE    EREK+R  E+G++       E++G R +EERE   RRR+
Sbjct: 51  GKKERESERKKERREREKRKREREKERKRERGKK-------EKKGERKKEERERKKRRRE 103

Query: 436 RQY---ERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERA 492
           ++    E  E+R+++  + +G   +E  ER  +E+R R+ ++E+  K+ E   ++ RER 
Sbjct: 104 KENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER--EKERERK 161

Query: 493 EQIRRERAQRAARAKQRQEGQ-LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSL 551
           E+ +RER Q   + ++R+E +  +R+KRE +R ER +       R R++R+ER+  R   
Sbjct: 162 ERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKE------RERKERRERKKERKKK 215

Query: 552 EASLGRAQENYEHLAIGRKLERSEQLTRERR 582
           E      Q++ +     R+ ER ++  +ER+
Sbjct: 216 EERKKERQKDRQ--TNWREKERGKRERKERK 244



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 57/210 (27%), Positives = 112/210 (53%), Gaps = 10/210 (4%)

Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
           R+   E    G  ER+ +       R + +    ++R    G+ E +    K+ RER++R
Sbjct: 41  REREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKR 100

Query: 400 EKQRALEQGRRAWAAQVEER--RGRRGREEREAARRRQRQYERSEERRRELAERQGLLRR 457
            +++  ++G      + +E+  RGR  +E +E  R+ +R+ E  +ER R+  ER+    R
Sbjct: 101 RREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREK--ER 158

Query: 458 ERAERAAREDR-LRKLQQEQNLKQREEGLQEGRERAEQIR-RERAQRAARAKQRQEGQLQ 515
           ER ER  RE + + + ++E+  K+R+E  +  R R E+ + RER +R  R K+R++ + +
Sbjct: 159 ERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEER 218

Query: 516 REKRELSRAERARHEALLQGRTRQQRQERE 545
           +++R+  R    R +     R +++R+ER+
Sbjct: 219 KKERQKDRQTNWREKE----RGKRERKERK 244



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 68/259 (26%), Positives = 125/259 (48%), Gaps = 38/259 (14%)

Query: 373 LEQRAAAHGQWELQRVHAKQRR--------EREEREKQRALEQGRRAWAAQVEERRG-RR 423
           +  RAA     ELQ V              + E RE++R +E  +     +  ER+  RR
Sbjct: 5   ISSRAAVKLNTELQMVSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERR 64

Query: 424 GREEREAARRRQRQYERSE-----ERRRELAERQGLLRRERAERAAREDRLRKLQQEQNL 478
            RE+R+  R ++R+ ER +     ER++E  ER    ++ R E+  +E   ++ ++++  
Sbjct: 65  EREKRKREREKERKRERGKKEKKGERKKEERER----KKRRREKENKEGEEKEKRKKKEK 120

Query: 479 KQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTR 538
           K+R    +EG+ER  +  R+R +R  R ++++E + +RE++E  + ER +     + R  
Sbjct: 121 KERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKE 180

Query: 539 QQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHV 598
           ++R+ER+           + + N +     RK ER  +  RER+   +      +     
Sbjct: 181 KERKERK-----------KRERNRKE----RKKERERKERRERKKERKKKEERKKE---- 221

Query: 599 REKVREETNTRSFDRMVRE 617
           R+K R +TN R  +R  RE
Sbjct: 222 RQKDR-QTNWREKERGKRE 239



 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 43/141 (30%), Positives = 81/141 (57%), Gaps = 5/141 (3%)

Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERR-RELA 449
           K+  E+E+R+K+   E+GR +   +  ER+  R REER+   R++ + E+  ER+ R+  
Sbjct: 107 KEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKR 166

Query: 450 ERQ--GLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
           ER+  G    ER E+  +E + R+  +++  K+RE   +E RER ++ +++  ++  R K
Sbjct: 167 ERKQVGEKEEERKEKERKERKKRERNRKERKKERER--KERRERKKERKKKEERKKERQK 224

Query: 508 QRQEGQLQREKRELSRAERAR 528
            RQ    ++E+ +  R ER +
Sbjct: 225 DRQTNWREKERGKRERKERKK 245



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 30/141 (21%), Positives = 60/141 (42%), Gaps = 8/141 (5%)

Query: 487 EGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREG 546
           E RER  +I   +  +  R  +R++ + +REKR+  R +  + E        + ++E++G
Sbjct: 37  EIREREREIETRKEGKKERESERKKERREREKRKREREKERKRE--------RGKKEKKG 88

Query: 547 LRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREET 606
            R   E    + +   E+     K +R ++  +ER    +  +   R     RE+ +E  
Sbjct: 89  ERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERE 148

Query: 607 NTRSFDRMVREAQLHASLDRK 627
             +      RE +     +RK
Sbjct: 149 RKKEEREKERERKERKKRERK 169



 Score = 30.4 bits (67), Expect = 5.1
 Identities = 29/138 (21%), Positives = 56/138 (40%), Gaps = 19/138 (13%)

Query: 317 GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQR 376
           GR+   G      +  +  ER  R+ + E   +    ++RK         +EE    ++R
Sbjct: 124 GRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKER 183

Query: 377 AAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQR 436
                +   ++   K+R  +E RE+                 ++ R+ +EER+  R++ R
Sbjct: 184 KERKKRERNRKERKKERERKERRER-----------------KKERKKKEERKKERQKDR 226

Query: 437 Q--YERSEERRRELAERQ 452
           Q  +   E  +RE  ER+
Sbjct: 227 QTNWREKERGKRERKERK 244


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score = 89.7 bits (221), Expect = 7e-18
 Identities = 99/373 (26%), Positives = 153/373 (41%), Gaps = 70/373 (18%)

Query: 157 ERRAKLQQCRAERERIMREE--KRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL- 213
           E++ K ++   E+  + RE   K+R   P SP A  +A+ A+  +P + +  S  S S  
Sbjct: 416 EKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWH 475

Query: 214 -PASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSY 272
            PASP P        SP    T PP   S  G  + S     RR+E A  S S A     
Sbjct: 476 RPASPCP--------SPGPGHTLPPKPPSPRGTTA-SPKGRVRRKEEAKESPSAAGPEDK 526

Query: 273 SGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTA 332
           S    R       A+  +  P+ + S T   P +       P      +       P T 
Sbjct: 527 SQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTP 586

Query: 333 ----------QHVERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHG 381
                     +   R++ + R + R  R   E++R++ A    R +EE L  E  A A  
Sbjct: 587 SKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAER 646

Query: 382 QWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERS 441
           + E     A++R E+E REK +A                      E+E   R Q+Q E +
Sbjct: 647 EAE-----ARRREEQEAREKAQA----------------------EQEEQERLQKQKEEA 679

Query: 442 EERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQI-RRERA 500
           E R RE AERQ                  +L++E++ +Q+E+  QE R+R E+I +R R 
Sbjct: 680 EARSREEAERQ------------------RLEREKHFQQQEQERQERRKRLEEIMKRTRK 721

Query: 501 QRAARAKQRQEGQ 513
              +  KQ+Q+ +
Sbjct: 722 SEVSETKQKQDSK 734



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 100/390 (25%), Positives = 158/390 (40%), Gaps = 45/390 (11%)

Query: 182 TPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAGS 241
           +PL+P +   +    A A   G     ++     SPAP   R+   SP   + +      
Sbjct: 368 SPLTPCSVTRSVHRCAPAGERGERRKPNAGG---SPAP-VRRRPEASPVQKKEKKDKERE 423

Query: 242 RTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTT 301
               KS      S ++  +L +   A  S+ +   L      P++ AR S P    S++ 
Sbjct: 424 NEKEKSALARERSLKKRQSLPASPRARLSASTASELS-----PKSKARPSSP----STSW 474

Query: 302 NAPGRPSALTLVPITGRSFSLGDLSHSPQ--TAQHVERIVRQVRAERGLRGVPERDRKIA 359
           + P  P      P  G   +L     SP+  TA    R+ R+  A+         D K  
Sbjct: 475 HRPASPC-----PSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPED-KSQ 528

Query: 360 ALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEER 419
           +   A +++E       A +           K++   E      A+     A A  V   
Sbjct: 529 SKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAET-PTDAAVLTSPPAPAPPVTPS 587

Query: 420 RGRRGREEREAA--------RRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRK 471
           +   G  +RE A        R+ + Q ER E+ RR  AER    +R R E+ ARE   R 
Sbjct: 588 KPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERD---KRMREEQLAREAEARA 644

Query: 472 LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEA 531
            ++E   ++REE  QE RE+A Q  +E  +R  + K+  E +  RE+ E  R ER +H  
Sbjct: 645 -EREAEARRREE--QEAREKA-QAEQEEQERLQKQKEEAEAR-SREEAERQRLEREKH-- 697

Query: 532 LLQGRTRQQRQEREGLRSSLEASLGRAQEN 561
                 +QQ QER+  R  LE  + R +++
Sbjct: 698 -----FQQQEQERQERRKRLEEIMKRTRKS 722



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 35/131 (26%), Positives = 64/131 (48%), Gaps = 2/131 (1%)

Query: 478 LKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRT 537
           L ++    +E RER EQ RR +A+R  R ++ Q  +    + E     R R E   + + 
Sbjct: 603 LAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKA 662

Query: 538 RQQRQEREGLRSSLEASLGRAQENYEHLAIGRK--LERSEQLTRERRSALESARSTARAS 595
           + +++E+E L+   E +  R++E  E   + R+   ++ EQ  +ERR  LE      R S
Sbjct: 663 QAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKS 722

Query: 596 FHVREKVREET 606
                K ++++
Sbjct: 723 EVSETKQKQDS 733



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 6/97 (6%)

Query: 425 REEREAARRRQRQYERSEERRRELAERQGL-LRRERAERAAREDRLRKLQQEQNLKQREE 483
           +E ++A  R +   ER EER + LA ++ + L +E   +A RE +L    QE+  +  E+
Sbjct: 130 QEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQL----QERRRRLEEQ 185

Query: 484 GLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRE 520
            L+  + RA    R+R Q+  + K+R E  +QR  ++
Sbjct: 186 RLKAEQRRAALEERQR-QKLEKNKERYEAAIQRSVKK 221



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 34/121 (28%), Positives = 59/121 (48%), Gaps = 15/121 (12%)

Query: 441 SEERRRELAERQGLLRRERAERA---AREDRLRKLQQEQNLKQREEGLQEGRERAEQIRR 497
           +++  ++  ER  L +  R ERA   A +  +   ++E+    RE+ LQE R R E+ R 
Sbjct: 128 TKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187

Query: 498 ERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ----RQEREGLRSSLEA 553
           +  QR A  ++RQ  +L++ K         R+EA +Q   ++     RQ+R     +L  
Sbjct: 188 KAEQRRAALEERQRQKLEKNKE--------RYEAAIQRSVKKTWAEIRQQRWSWAGALHH 239

Query: 554 S 554
           S
Sbjct: 240 S 240



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 23/74 (31%), Positives = 37/74 (50%), Gaps = 2/74 (2%)

Query: 389 HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRREL 448
           H   +  REER K  A ++    W  + E+ +  R ++ +E  RR + Q  ++E+RR  L
Sbjct: 139 HKLAKERREERAKYLAAKKA--VWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAAL 196

Query: 449 AERQGLLRRERAER 462
            ERQ     +  ER
Sbjct: 197 EERQRQKLEKNKER 210



 Score = 35.0 bits (79), Expect = 0.21
 Identities = 53/230 (23%), Positives = 89/230 (38%), Gaps = 23/230 (10%)

Query: 211 ASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSS 270
           A  P +   R   +  PSP    + PPP  S     +   D+    +    S +      
Sbjct: 11  AGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPP-DTPPAMKNATSSKQLPLEPE 69

Query: 271 SYSGESLRELRWPPRASARNSCPAGSASSTTNAP-------GRPSALTLVPITGRSFSLG 323
           S SG+       P  A  +   P+  A S    P        RP   +  P    S +  
Sbjct: 70  SPSGQV-----GPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQP----SPTAV 120

Query: 324 DLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA---LMLARHQEELLLLE-QRAAA 379
             S SP T Q V++   + +  +  R   ER + +AA   + L + ++   L E Q    
Sbjct: 121 PASDSPPTKQEVKKAGERHKLAKERR--EERAKYLAAKKAVWLEKEEKAKALREKQLQER 178

Query: 380 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREERE 429
             + E QR+ A+QRR   E  +++ LE+ +  + A ++    +   E R+
Sbjct: 179 RRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQ 228



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 63/274 (22%), Positives = 98/274 (35%), Gaps = 41/274 (14%)

Query: 39  EAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDC 98
           E+ ++  P+ +   +  AS+   SA+ A P  +  P       ++EQ P           
Sbjct: 516 ESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPA---------- 565

Query: 99  PEAEGSRYVLTSPRSLEACARCAVKPV------ELLPRALADLVREAPGRSMRVATGLYE 152
            E      VLTSP +  A      KP+      E   R LA+  R+A  R  R      E
Sbjct: 566 -ETPTDAAVLTSPPA-PAPPVTPSKPMAGTTDREEATRLLAEKRRQA--REQR------E 615

Query: 153 AYEAERRAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSAS 212
             E ERR +     AER++ MREE+          A  A A A   A +       +   
Sbjct: 616 REEQERRLQ-----AERDKRMREEQ---------LAREAEARAEREAEARRREEQEAREK 661

Query: 213 LPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSY 272
             A    +   +     + AR++      R  R+ H       R+E     E     +  
Sbjct: 662 AQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRK 721

Query: 273 SGES-LRELRWPPRASARNSCPAGSASSTTNAPG 305
           S  S  ++ +    A+A  S P    +    +PG
Sbjct: 722 SEVSETKQKQDSKEANANGSSPEPVKAVEARSPG 755



 Score = 30.4 bits (67), Expect = 5.1
 Identities = 32/112 (28%), Positives = 55/112 (49%), Gaps = 12/112 (10%)

Query: 401 KQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERA 460
           KQ   + G R   A+  ERR  R +        ++  +   EE+ + L E+Q   RR R 
Sbjct: 129 KQEVKKAGERHKLAK--ERREERAKY----LAAKKAVWLEKEEKAKALREKQLQERRRRL 182

Query: 461 ERAAREDRLRKLQQEQNLKQRE-EGLQEGRERAE-QIRRERAQRAARAKQRQ 510
           E    E RL+  Q+   L++R+ + L++ +ER E  I+R   +  A  +Q++
Sbjct: 183 E----EQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 70/274 (25%), Positives = 123/274 (44%), Gaps = 10/274 (3%)

Query: 333 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQ 392
           +H ER  R+   ER      ER R+       R ++     E+   A  +   +R   + 
Sbjct: 204 RHSER-GRERERERETETETERKRQTDR---ERDRQRKTEREREKQAERERASERETERD 259

Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
           +    ER++ R  ++ ++    Q + +R RR   +RE  R+R+RQ ER  ER R     +
Sbjct: 260 KERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRER 319

Query: 453 GLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEG 512
              R    ER    +R R+ ++E+  K++ E     RER  Q  RE  ++A R ++R+  
Sbjct: 320 ERERERERERQRETERDREKERERKRKRQTE---MDRERNRQTGREGRRQAERERERERE 376

Query: 513 QLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSS---LEASLGRAQENYEHLAIGR 569
           + ++  RE    ER R     + R RQ  ++R+G R +    E    R  E        R
Sbjct: 377 RDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGRER 436

Query: 570 KLERSEQLTRERRSALESARSTARASFHVREKVR 603
           + ++  +  RER++  ++ R   R++ +V    R
Sbjct: 437 EKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPR 470



 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 72/264 (27%), Positives = 118/264 (44%), Gaps = 35/264 (13%)

Query: 380 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQY 438
           H + +  R   ++R+   ER++QR  E+ R+    +  ER G RGR+ + +  R R+RQ 
Sbjct: 94  HRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQR 153

Query: 439 ERSEERRREL-AERQGLLRRERAE-------RAAREDRLRKLQQEQNLKQR--EEGLQEG 488
           +  +ER R+   ERQ    R R +       R  R +R R+ ++E   + R  E G +  
Sbjct: 154 DAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERE 213

Query: 489 RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLR 548
           RER  +   ER ++  R + RQ  + +RE+ + +  ERA      + + R++ ++R+  R
Sbjct: 214 RERETETETERKRQTDRERDRQR-KTEREREKQAERERASERETERDKERERERDRDRDR 272

Query: 549 SSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNT 608
                               R+ ER  Q  R+R+   E  R T R     RE+ RE    
Sbjct: 273 DR------------------RQKERERQTDRKRQRRTERDRETERKRERQRERERERERN 314

Query: 609 RSFDR-----MVREAQLHASLDRK 627
           R  +R       RE Q     DR+
Sbjct: 315 RKRERERERERERERQRETERDRE 338



 Score = 86.3 bits (212), Expect = 8e-17
 Identities = 64/246 (26%), Positives = 116/246 (47%), Gaps = 22/246 (8%)

Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
           ++R  ++ERE++R   Q  R    + + +R RR  ++R   R R R+ +R  E+ RE   
Sbjct: 54  RERNRQKERERRREKRQTER----ETDRKRERRREKDRHRKRDRHRERQRDREKERERQT 109

Query: 451 RQGLLRRERAERAAREDRLRKLQQE-QNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 509
            +   R+   ER  +++R R+ ++E +  + R+   Q  RER     +ER ++  R +QR
Sbjct: 110 DRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQR 169

Query: 510 QEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHL---- 565
           Q  + ++++RE  +  + R E       R++++E+E       +  GR +E         
Sbjct: 170 QTERNRQKEREREKNRQERRE-------RERQREKENKTEDRHSERGRERERERETETET 222

Query: 566 ----AIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLH 621
                  R+ +R  +  RER    E  R++ R +   R+K RE    R  DR  R+ +  
Sbjct: 223 ERKRQTDRERDRQRKTEREREKQAERERASERET--ERDKERERERDRDRDRDRRQKERE 280

Query: 622 ASLDRK 627
              DRK
Sbjct: 281 RQTDRK 286



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 81/307 (26%), Positives = 134/307 (43%), Gaps = 26/307 (8%)

Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
           R+   +R  R   +R RK       RH+E     E+        E  R   K+R  ++ER
Sbjct: 73  RETDRKRERRREKDRHRK-----RDRHRERQRDREKERERQTDRERDRQREKERNRQKER 127

Query: 400 EKQ--RALEQGRRAWAAQVEERRGRRGRE---EREAARRRQRQYERSEERRRELAE-RQG 453
           E++  R  E+GR        ER  +R  E   ER+  R RQRQ ER+ ++ RE  + RQ 
Sbjct: 128 ERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQE 187

Query: 454 LLRRER------------AERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQ 501
              RER            +ER    +R R+ + E   K++ +  ++ + + E+ R ++A+
Sbjct: 188 RRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAE 247

Query: 502 RAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQEN 561
           R   +++  E   +RE+      +R R +   + +T ++RQ R       E    R +E 
Sbjct: 248 RERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRER 307

Query: 562 YEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMV-REAQL 620
                  RK ER  +  RER    E+ R   R     R++ R+    R  +R   RE + 
Sbjct: 308 ERERERNRKRERERERERERERQRETERD--REKERERKRKRQTEMDRERNRQTGREGRR 365

Query: 621 HASLDRK 627
            A  +R+
Sbjct: 366 QAERERE 372



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 79/297 (26%), Positives = 124/297 (41%), Gaps = 25/297 (8%)

Query: 345 ERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRA 404
           +R   G  ER+R+  A    + +E     E++       + +R   K R+ER ERE+QR 
Sbjct: 140 DRQTDGQRERERQRDA---EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQRE 196

Query: 405 LEQGRRAWAAQVEERRGRRGRE-------EREAARRRQ----RQYERSEERRRE-LAERQ 452
            E        + E+R   RGRE       E E  R+RQ    R  +R  ER RE  AER+
Sbjct: 197 KEN-------KTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERE 249

Query: 453 GLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEG 512
               RE  ER    +R R   ++++ +Q+E   Q  R+R  +  R+R     R +QR+  
Sbjct: 250 RASERE-TERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERE 308

Query: 513 QLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLE 572
           + +   R+  R      E   Q  T + R++    +   +  + R +         R+ E
Sbjct: 309 RERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAE 368

Query: 573 RSEQLTRER-RSALESARSTARASFHVREKVREETNTRSFD-RMVREAQLHASLDRK 627
           R  +  RER R +        R     R+K RE    +  D +   E Q     DR+
Sbjct: 369 RERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRE 425



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 82/293 (27%), Positives = 125/293 (42%), Gaps = 22/293 (7%)

Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
           RQ R ER      ER R+       RH E     E+      + E +R   ++R  + + 
Sbjct: 185 RQERRER------ERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKT 238

Query: 400 EKQRALEQGRRAWAAQVEERRGRRGREEREAARRR-QRQYERSEERRRELAERQGLLRRE 458
           E++R  +Q  R  A++ E  R +    ER+  R R +RQ ER  +  R   +RQ    R+
Sbjct: 239 ERERE-KQAERERASERETERDKERERERDRDRDRDRRQKERERQTDR---KRQRRTERD 294

Query: 459 R-AERAAREDRLRKLQQEQNLK-QREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQR 516
           R  ER     R R+ ++E+N K +RE   +  RER  +  R+R +   R ++RQ    + 
Sbjct: 295 RETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRE 354

Query: 517 EKRELSR-----AERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKL 571
             R+  R     AER R     + R RQ  +ERE      +    R +E        R  
Sbjct: 355 RNRQTGREGRRQAERERERE--RERDRQSARERE--ERERDRDRDRQKERERQTEKDRDG 410

Query: 572 ERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASL 624
           +R  +  RER    ES R   R     ++K RE    R  DR     +  ++L
Sbjct: 411 QRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTL 463



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 43/177 (24%), Positives = 82/177 (46%), Gaps = 8/177 (4%)

Query: 438 YERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRR 497
           + R     +E   R+GL +  +       +R R+ ++E+  ++R+   +  R+R  +  +
Sbjct: 26  FSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREK 85

Query: 498 ERAQRAARAKQRQEGQLQREKRELSR-AERARHEALLQGRTRQQRQEREGLRSSLEASLG 556
           +R ++  R ++RQ  + +  +R+  R  +R R +   + + R++  EREG R     + G
Sbjct: 86  DRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDG 145

Query: 557 RAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDR 613
           + +   +  A   + ER  Q  RER+   E  R   R     REK R+E   R   R
Sbjct: 146 QRERERQRDA---EKERERQTDRERQRQTERNRQKERE----REKNRQERRERERQR 195



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 52/175 (29%), Positives = 77/175 (44%), Gaps = 11/175 (6%)

Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQR-REREE 398
           RQ   ER      ER RK    M  R +      E R  A  + E +R   +Q  REREE
Sbjct: 329 RQRETERDREKERERKRKRQTEM-DRERNRQTGREGRRQAERERERERERDRQSAREREE 387

Query: 399 REKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRRELA-ERQGLLR 456
           RE+ R  ++ +        ER+  + R+ +RE  ++R+R+ +R  ER RE   ER+    
Sbjct: 388 RERDRDRDRQKE------RERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKG 441

Query: 457 RERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQE 511
           RER +R  + DR    Q++++        +  R    Q    R  R  R K   E
Sbjct: 442 RER-DRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPE 495


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 124/514 (24%), Positives = 212/514 (41%), Gaps = 64/514 (12%)

Query: 104 SRYVLTSPRSLEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQ 163
           S  VL    SL A     V+      R LA    E P  S R+    Y     ER   ++
Sbjct: 314 SPQVLAQKYSLVAKQESVVRRAS---RRLAKKTAEEPAASGRIICHSY----LERLLNVE 366

Query: 164 QCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAAR 223
                 +++  E+K        P  A   AAA    P    ++S      P +    A  
Sbjct: 367 V----PQKVGSEQKE------PPEEAEPVAAAEPEVPENNGNNSW-----PHNDTEIANS 411

Query: 224 KASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLR---EL 280
             +P P+++  + P AG +   K+   D      + A    S   + S   E      E 
Sbjct: 412 TPNPKPAASSPETPSAGQQEA-KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEE 470

Query: 281 RWPPRASARNS-CPAGSASSTTNA---PGRPSALTLVPITG-----RSFSLGD----LSH 327
             PPR+   +S CPA              + + + + P +      +SF   +    +  
Sbjct: 471 LQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDP 530

Query: 328 SPQTAQHVERIVRQVRAERGLRGVPERD--RKIAALMLARHQEELLLLEQRAAAHGQWEL 385
             +  Q +E + R+  AE+  R   E D  R++  + L R +    +L+ R       E 
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590

Query: 386 QRVHAKQR------REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
           ++   +Q+      +  + +E++ A E+ ++  AA+  E    R ++E EA R R  Q E
Sbjct: 591 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 650

Query: 440 RSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRE--RAEQIRR 497
             E R +EL +++    +ER  +AA   RL + Q+EQ  +++E   QE RE  R EQ RR
Sbjct: 651 EEERRHQELLQKKKEEEQERLRKAAEAKRLAE-QREQERREQERREQERREQERREQERR 709

Query: 498 ERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGR 557
           E+ ++ A  ++R+E +  + +REL   E+A             R ++E L+  LE    +
Sbjct: 710 EQERQLAEQERRREQERLQAERELQEREKA------------LRLQKEQLQRELEEK--K 755

Query: 558 AQENYEHLAIGRKLERSEQLTRERRSALESARST 591
            +E  + LA  +  E  E+  +E   A ++   T
Sbjct: 756 KKEEQQRLAERQLQEEQEKKAKEAAGASKALNVT 789



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 68/246 (27%), Positives = 121/246 (49%), Gaps = 29/246 (11%)

Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
           R + +E+E+QR     R+  A Q+     RR + E +  RR +    + EER R++    
Sbjct: 527 RMDPKEKERQRLENLRRKEEAEQL-----RRQKVEEDKRRRLEEVKLKREERLRKV---- 577

Query: 453 GLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEG 512
            L  RER E+   E   +K Q EQ   Q +E  ++ +E  E++  E+A++ A AK+ +E 
Sbjct: 578 -LQARERVEQMKEE---KKKQIEQKFAQIDEKTEKAKE--ERLAEEKAKKKAAAKKMEEV 631

Query: 513 QLQREKRELSRA--------ERARHEALLQGRTRQQRQEREGLRSSLEAS-LGRAQENYE 563
           + +R++ E +R         E  RH+ LLQ   +++ +E+E LR + EA  L   +E   
Sbjct: 632 EARRKQEEEARRLRWLQQEEEERRHQELLQ---KKKEEEQERLRKAAEAKRLAEQREQER 688

Query: 564 HLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVR--EAQLH 621
                R+ ER EQ  RE+    +  +   +     +E+++ E   +  ++ +R  + QL 
Sbjct: 689 REQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQ 748

Query: 622 ASLDRK 627
             L+ K
Sbjct: 749 RELEEK 754



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 65/261 (24%), Positives = 121/261 (46%), Gaps = 47/261 (18%)

Query: 384 ELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARR-RQRQYERSE 442
           E QR+   +R+E  E+ +++ +E+ +R    +V+ +R  R R+  +A  R  Q + E+ +
Sbjct: 534 ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKK 593

Query: 443 ERRRELAERQGLLRRERAERAARED------------------------RLRKLQQEQNL 478
           +  ++ A+      + + ER A E                         RLR LQQE+  
Sbjct: 594 QIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE 653

Query: 479 KQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTR 538
           ++ +E LQ+ +E  ++  R+ A+    A+QR++ + ++E+RE  R E+ R E   Q R  
Sbjct: 654 RRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE---QERRE 710

Query: 539 QQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHV 598
           Q+RQ  E  R          +   E L   R+L+  E+  R ++  L+           +
Sbjct: 711 QERQLAEQER----------RREQERLQAERELQEREKALRLQKEQLQR---------EL 751

Query: 599 REKVREETNTRSFDRMVREAQ 619
            EK ++E   R  +R ++E Q
Sbjct: 752 EEKKKKEEQQRLAERQLQEEQ 772



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 94/478 (19%), Positives = 176/478 (36%), Gaps = 46/478 (9%)

Query: 167 AERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLP-ASPAPRAARKA 225
           ++ E   ++ K R+   ++  ++  A          G+  S S   +   SP PR +   
Sbjct: 214 SDEESTPKKSKARILESIT-VSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAF 272

Query: 226 SPSPSSARTQPP--------PAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESL 277
             SP   R   P        P GSRT  +S     ++     + S +  A   S   +  
Sbjct: 273 PDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIA---PSSPSPQVLAQKYSLVAKQE 329

Query: 278 RELRWPPRASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVER 337
             +R   R  A+ +    +AS           L  V +  +  S  +    P+ A+ V  
Sbjct: 330 SVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGS--EQKEPPEEAEPVAA 387

Query: 338 IVRQVRAERGLRGVPERDRKIAALML----ARHQEELLLLEQRAAAHGQWELQRVHAKQ- 392
              +V    G    P  D +IA        A    E     Q+ A   Q +  R   +  
Sbjct: 388 AEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSA 447

Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR--RRQRQYERSEERRRELAE 450
           RR+R  ++    L++ +     +++  R +       A++  R  R +  + +R      
Sbjct: 448 RRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRN----- 502

Query: 451 RQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRR-ERAQRAARAKQR 509
            Q L+    A R+  +  +++     N   R +  ++ R+R E +RR E A++  R K  
Sbjct: 503 -QMLMTPTSAPRSVMKSFIKR-----NTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVE 556

Query: 510 QEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGR 569
           ++ + + E+ +L R ER R     + R  Q ++E+            + Q   +   I  
Sbjct: 557 EDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK------------KKQIEQKFAQIDE 604

Query: 570 KLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
           K E++++       A + A +        R K  EE     + +   E + H  L +K
Sbjct: 605 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 662


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 125/518 (24%), Positives = 212/518 (40%), Gaps = 68/518 (13%)

Query: 104 SRYVLTSPRSLEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQ 163
           S  VL    SL A     V+      R LA    E P  S R+    Y     ER   ++
Sbjct: 314 SPQVLAQKYSLVAKQESVVRRAS---RRLAKKTAEEPAASGRIICHSY----LERLLNVE 366

Query: 164 QCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAAR 223
                 +++  E+K        P  A   AAA    P    ++S      P +    A  
Sbjct: 367 V----PQKVGSEQKE------PPEEAEPVAAAEPEVPENNGNNSW-----PHNDTEIANS 411

Query: 224 KASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLR---EL 280
             +P P+++  + P AG +   K+   D      + A    S   + S   E      E 
Sbjct: 412 TPNPKPAASSPETPSAGQQEA-KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEE 470

Query: 281 RWPPRASARNS-CPAGSASSTTNA---PGRPSALTLVPITG-----RSFSLGDL------ 325
             PPR+   +S CPA              + + + + P +      +SF   +       
Sbjct: 471 LQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDP 530

Query: 326 --SHSPQTAQHVERIVRQVRAERGLRGVPERD--RKIAALMLARHQEELLLLEQRAAAHG 381
             S   +  Q +E + R+  AE+  R   E D  R++  + L R +    +L+ R     
Sbjct: 531 KCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQ 590

Query: 382 QWELQRVHAKQR------REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQ 435
             E ++   +Q+      +  + +E++ A E+ ++  AA+  E    R ++E EA R R 
Sbjct: 591 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 650

Query: 436 RQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRE--RAE 493
            Q E  E R +EL +++    +ER  +AA   RL + Q+EQ  +++E   QE RE  R E
Sbjct: 651 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAE-QREQERREQERREQERREQERRE 709

Query: 494 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
           Q RRE+ ++ A  ++R+E +  + +REL   E+A             R ++E L+  LE 
Sbjct: 710 QERREQERQLAEQERRREQERLQAERELQEREKA------------LRLQKEQLQRELEE 757

Query: 554 SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARST 591
              + +E  + LA  +  E  E+  +E   A ++   T
Sbjct: 758 K--KKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVT 793



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 65/261 (24%), Positives = 121/261 (46%), Gaps = 47/261 (18%)

Query: 384 ELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARR-RQRQYERSE 442
           E QR+   +R+E  E+ +++ +E+ +R    +V+ +R  R R+  +A  R  Q + E+ +
Sbjct: 538 ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKK 597

Query: 443 ERRRELAERQGLLRRERAERAARED------------------------RLRKLQQEQNL 478
           +  ++ A+      + + ER A E                         RLR LQQE+  
Sbjct: 598 QIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE 657

Query: 479 KQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTR 538
           ++ +E LQ+ +E  ++  R+ A+    A+QR++ + ++E+RE  R E+ R E   Q R  
Sbjct: 658 RRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE---QERRE 714

Query: 539 QQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHV 598
           Q+RQ  E  R          +   E L   R+L+  E+  R ++  L+           +
Sbjct: 715 QERQLAEQER----------RREQERLQAERELQEREKALRLQKEQLQR---------EL 755

Query: 599 REKVREETNTRSFDRMVREAQ 619
            EK ++E   R  +R ++E Q
Sbjct: 756 EEKKKKEEQQRLAERQLQEEQ 776



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 67/241 (27%), Positives = 118/241 (48%), Gaps = 29/241 (12%)

Query: 398 EREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRR 457
           E+E+QR     R+  A Q+     RR + E +  RR +    + EER R++     L  R
Sbjct: 536 EKERQRLENLRRKEEAEQL-----RRQKVEEDKRRRLEEVKLKREERLRKV-----LQAR 585

Query: 458 ERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQRE 517
           ER E+   E   +K Q EQ   Q +E  ++ +E  E++  E+A++ A AK+ +E + +R+
Sbjct: 586 ERVEQMKEE---KKKQIEQKFAQIDEKTEKAKE--ERLAEEKAKKKAAAKKMEEVEARRK 640

Query: 518 KRELSRA--------ERARHEALLQGRTRQQRQEREGLRSSLEAS-LGRAQENYEHLAIG 568
           + E +R         E  RH+ LLQ   +++ +E+E LR + EA  L   +E        
Sbjct: 641 QEEEARRLRWLQQEEEERRHQELLQ---KKKEEEQERLRKAAEAKRLAEQREQERREQER 697

Query: 569 RKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVR--EAQLHASLDR 626
           R+ ER EQ  RE+    +  +   +     +E+++ E   +  ++ +R  + QL   L+ 
Sbjct: 698 REQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 757

Query: 627 K 627
           K
Sbjct: 758 K 758



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 93/478 (19%), Positives = 172/478 (35%), Gaps = 42/478 (8%)

Query: 167 AERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLP-ASPAPRAARKA 225
           ++ E   ++ K R+   ++  ++  A          G+  S S   +   SP PR +   
Sbjct: 214 SDEESTPKKSKARILESIT-VSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAF 272

Query: 226 SPSPSSARTQPP--------PAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESL 277
             SP   R   P        P GSRT  +S     ++     + S +  A   S   +  
Sbjct: 273 PDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIA---PSSPSPQVLAQKYSLVAKQE 329

Query: 278 RELRWPPRASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVER 337
             +R   R  A+ +    +AS           L  V +  +  S  +    P+ A+ V  
Sbjct: 330 SVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGS--EQKEPPEEAEPVAA 387

Query: 338 IVRQVRAERGLRGVPERDRKIAALML----ARHQEELLLLEQRAAAHGQWELQRVHAKQ- 392
              +V    G    P  D +IA        A    E     Q+ A   Q +  R   +  
Sbjct: 388 AEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSA 447

Query: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR--RRQRQYERSEERRRELAE 450
           RR+R  ++    L++ +     +++  R +       A++  R  R +  + +R + L  
Sbjct: 448 RRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMT 507

Query: 451 RQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRR-ERAQRAARAKQR 509
                R        R   LR       +  +   +++ R+R E +RR E A++  R K  
Sbjct: 508 PTSAPRSVMKSFIKRNTPLR-------MDPKCSFVEKERQRLENLRRKEEAEQLRRQKVE 560

Query: 510 QEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGR 569
           ++ + + E+ +L R ER R     + R  Q ++E+            + Q   +   I  
Sbjct: 561 EDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK------------KKQIEQKFAQIDE 608

Query: 570 KLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
           K E++++       A + A +        R K  EE     + +   E + H  L +K
Sbjct: 609 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 666


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
           sapiens]
          Length = 1293

 Score = 86.3 bits (212), Expect = 8e-17
 Identities = 78/244 (31%), Positives = 119/244 (48%), Gaps = 31/244 (12%)

Query: 368 EELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRAL-EQGRRAWAAQVEERRGRRGRE 426
           E+L  LE+  AA  + E +    + +RE EER++Q  L  Q       Q EE R RR  E
Sbjct: 718 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 777

Query: 427 E-----REAARRRQRQYERSEERRRELAERQGL---------LRRERAERAAREDRLRKL 472
           E     +E A RRQR+ E +  R+RE  ERQ            RRE  ER  +E+ LRK 
Sbjct: 778 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 837

Query: 473 QQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQRE-----KRELSRAERA 527
           ++E     REE  +E + R E+ R    + AAR +  +E + ++E     ++EL R  + 
Sbjct: 838 EEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 895

Query: 528 RHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-------HLAIGRKL--ERSEQLT 578
           + EAL + + +QQ+Q+   ++    ++ G+              LA  +KL  ER  QL 
Sbjct: 896 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 955

Query: 579 RERR 582
            E+R
Sbjct: 956 EEQR 959



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 77/280 (27%), Positives = 127/280 (45%), Gaps = 20/280 (7%)

Query: 333  QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQE-ELLLLEQRAAAHGQWELQRVHA- 390
            Q  E + RQ   ER  R   E  R+     L R +E E+ L  QR     Q + + +   
Sbjct: 758  QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 817

Query: 391  -KQRREREEREKQRAL----EQGRRAWAAQVEERRGR----RGREEREAARRRQRQYERS 441
             ++RRE EER KQ  L    E+    WA + EE + R    R R E EAAR R   +E  
Sbjct: 818  EERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR---HEEE 874

Query: 442  EERRREL-AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERA 500
            E +R+EL  +RQ  L R+R ++     RL++ QQ+Q L Q +  L       +Q      
Sbjct: 875  ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK--LPSSSTWGQQSNTTAC 932

Query: 501  QRAARAKQRQEGQLQREK-RELSRAERARHEALLQGRTRQQRQEREGLR--SSLEASLGR 557
            Q  A     +  +L+ E+ R+L   +R +   L++   +QQ+Q+++ L    ++    G 
Sbjct: 933  QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 992

Query: 558  AQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 597
             +   E      +  + +Q  +++      AR+   ++ H
Sbjct: 993  TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1032



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 69/249 (27%), Positives = 120/249 (48%), Gaps = 25/249 (10%)

Query: 390 AKQRREREEREKQRALEQGR-----RAWAAQVEERRGRRGREEREAARRRQRQYERSEER 444
           A ++ ++ E+ K   LEQ R     RA   + E +R    R ++E   RRQ++ ER    
Sbjct: 716 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 775

Query: 445 RRELAER--QGLLRRER----AERAAREDRLRKLQQE--QNLKQREEGLQEGRERAEQIR 496
             ELA R  +  LRR+R    A R  RE+  R+ Q+E  + L++R    +E R++ E +R
Sbjct: 776 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 835

Query: 497 RERAQRAARAKQRQEGQLQREKREL---SRAERARHEALLQGRTRQQRQEREGL---RSS 550
           ++  + A  A++ +E Q + E+  L     A R RHE   + R   + Q ++ L   R  
Sbjct: 836 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 895

Query: 551 LEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRS 610
            + +L R Q+  +   +  +++     T  ++S   + +S A  S    +K+ EE     
Sbjct: 896 QQEALRRLQQQQQQQQLA-QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER---- 950

Query: 611 FDRMVREAQ 619
            +R +RE Q
Sbjct: 951 -ERQLREEQ 958



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 50/235 (21%), Positives = 108/235 (45%), Gaps = 11/235 (4%)

Query: 330  QTAQHVERIVRQVRAERGLRGVPE--RDRKIAALMLARHQEELLLLEQRAAAHGQWELQR 387
            Q  + + R+  + R E   R   E  R ++  A   AR +EE     +      + E  R
Sbjct: 809  QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 868

Query: 388  V-HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYER-SEERR 445
            + H ++ R+R+E E QR  E  R+    Q   RR ++ +++++ A+ +        ++  
Sbjct: 869  LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 928

Query: 446  RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE--EGLQEGRERAEQIRRERAQRA 503
                + Q  L     ++   E+R R+L++EQ  +QRE  + LQ+ +++ +Q +       
Sbjct: 929  TTACQSQATLSLAEIQK-LEEERERQLREEQRRQQRELMKALQQQQQQQQQ-KLSGWGNV 986

Query: 504  ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRA 558
            ++     +  L+ ++ E  + ++ + +   Q + +Q  + R    S+L  S+G +
Sbjct: 987  SKPSGTTKSLLEIQQEEARQMQKQQQQ---QQQHQQPNRARNNTHSNLHTSIGNS 1038


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
           sapiens]
          Length = 1320

 Score = 86.3 bits (212), Expect = 8e-17
 Identities = 78/244 (31%), Positives = 119/244 (48%), Gaps = 31/244 (12%)

Query: 368 EELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRAL-EQGRRAWAAQVEERRGRRGRE 426
           E+L  LE+  AA  + E +    + +RE EER++Q  L  Q       Q EE R RR  E
Sbjct: 745 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 804

Query: 427 E-----REAARRRQRQYERSEERRRELAERQGL---------LRRERAERAAREDRLRKL 472
           E     +E A RRQR+ E +  R+RE  ERQ            RRE  ER  +E+ LRK 
Sbjct: 805 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 864

Query: 473 QQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQRE-----KRELSRAERA 527
           ++E     REE  +E + R E+ R    + AAR +  +E + ++E     ++EL R  + 
Sbjct: 865 EEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 922

Query: 528 RHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-------HLAIGRKL--ERSEQLT 578
           + EAL + + +QQ+Q+   ++    ++ G+              LA  +KL  ER  QL 
Sbjct: 923 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 982

Query: 579 RERR 582
            E+R
Sbjct: 983 EEQR 986



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 77/280 (27%), Positives = 127/280 (45%), Gaps = 20/280 (7%)

Query: 333  QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQE-ELLLLEQRAAAHGQWELQRVHA- 390
            Q  E + RQ   ER  R   E  R+     L R +E E+ L  QR     Q + + +   
Sbjct: 785  QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 844

Query: 391  -KQRREREEREKQRAL----EQGRRAWAAQVEERRGR----RGREEREAARRRQRQYERS 441
             ++RRE EER KQ  L    E+    WA + EE + R    R R E EAAR R   +E  
Sbjct: 845  EERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR---HEEE 901

Query: 442  EERRREL-AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERA 500
            E +R+EL  +RQ  L R+R ++     RL++ QQ+Q L Q +  L       +Q      
Sbjct: 902  ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK--LPSSSTWGQQSNTTAC 959

Query: 501  QRAARAKQRQEGQLQREK-RELSRAERARHEALLQGRTRQQRQEREGLR--SSLEASLGR 557
            Q  A     +  +L+ E+ R+L   +R +   L++   +QQ+Q+++ L    ++    G 
Sbjct: 960  QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 1019

Query: 558  AQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 597
             +   E      +  + +Q  +++      AR+   ++ H
Sbjct: 1020 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1059



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 69/249 (27%), Positives = 120/249 (48%), Gaps = 25/249 (10%)

Query: 390 AKQRREREEREKQRALEQGR-----RAWAAQVEERRGRRGREEREAARRRQRQYERSEER 444
           A ++ ++ E+ K   LEQ R     RA   + E +R    R ++E   RRQ++ ER    
Sbjct: 743 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 802

Query: 445 RRELAER--QGLLRRER----AERAAREDRLRKLQQE--QNLKQREEGLQEGRERAEQIR 496
             ELA R  +  LRR+R    A R  RE+  R+ Q+E  + L++R    +E R++ E +R
Sbjct: 803 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 862

Query: 497 RERAQRAARAKQRQEGQLQREKREL---SRAERARHEALLQGRTRQQRQEREGL---RSS 550
           ++  + A  A++ +E Q + E+  L     A R RHE   + R   + Q ++ L   R  
Sbjct: 863 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 922

Query: 551 LEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRS 610
            + +L R Q+  +   +  +++     T  ++S   + +S A  S    +K+ EE     
Sbjct: 923 QQEALRRLQQQQQQQQLA-QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER---- 977

Query: 611 FDRMVREAQ 619
            +R +RE Q
Sbjct: 978 -ERQLREEQ 985



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 50/235 (21%), Positives = 108/235 (45%), Gaps = 11/235 (4%)

Query: 330  QTAQHVERIVRQVRAERGLRGVPE--RDRKIAALMLARHQEELLLLEQRAAAHGQWELQR 387
            Q  + + R+  + R E   R   E  R ++  A   AR +EE     +      + E  R
Sbjct: 836  QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 895

Query: 388  V-HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYER-SEERR 445
            + H ++ R+R+E E QR  E  R+    Q   RR ++ +++++ A+ +        ++  
Sbjct: 896  LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 955

Query: 446  RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE--EGLQEGRERAEQIRRERAQRA 503
                + Q  L     ++   E+R R+L++EQ  +QRE  + LQ+ +++ +Q +       
Sbjct: 956  TTACQSQATLSLAEIQK-LEEERERQLREEQRRQQRELMKALQQQQQQQQQ-KLSGWGNV 1013

Query: 504  ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRA 558
            ++     +  L+ ++ E  + ++ + +   Q + +Q  + R    S+L  S+G +
Sbjct: 1014 SKPSGTTKSLLEIQQEEARQMQKQQQQ---QQQHQQPNRARNNTHSNLHTSIGNS 1065


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 86.3 bits (212), Expect = 8e-17
 Identities = 78/244 (31%), Positives = 119/244 (48%), Gaps = 31/244 (12%)

Query: 368 EELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRAL-EQGRRAWAAQVEERRGRRGRE 426
           E+L  LE+  AA  + E +    + +RE EER++Q  L  Q       Q EE R RR  E
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 783

Query: 427 E-----REAARRRQRQYERSEERRRELAERQGL---------LRRERAERAAREDRLRKL 472
           E     +E A RRQR+ E +  R+RE  ERQ            RRE  ER  +E+ LRK 
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 843

Query: 473 QQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQRE-----KRELSRAERA 527
           ++E     REE  +E + R E+ R    + AAR +  +E + ++E     ++EL R  + 
Sbjct: 844 EEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901

Query: 528 RHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-------HLAIGRKL--ERSEQLT 578
           + EAL + + +QQ+Q+   ++    ++ G+              LA  +KL  ER  QL 
Sbjct: 902 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 961

Query: 579 RERR 582
            E+R
Sbjct: 962 EEQR 965



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 77/280 (27%), Positives = 127/280 (45%), Gaps = 20/280 (7%)

Query: 333  QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQE-ELLLLEQRAAAHGQWELQRVHA- 390
            Q  E + RQ   ER  R   E  R+     L R +E E+ L  QR     Q + + +   
Sbjct: 764  QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 823

Query: 391  -KQRREREEREKQRAL----EQGRRAWAAQVEERRGR----RGREEREAARRRQRQYERS 441
             ++RRE EER KQ  L    E+    WA + EE + R    R R E EAAR R   +E  
Sbjct: 824  EERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR---HEEE 880

Query: 442  EERRREL-AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERA 500
            E +R+EL  +RQ  L R+R ++     RL++ QQ+Q L Q +  L       +Q      
Sbjct: 881  ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK--LPSSSTWGQQSNTTAC 938

Query: 501  QRAARAKQRQEGQLQREK-RELSRAERARHEALLQGRTRQQRQEREGLR--SSLEASLGR 557
            Q  A     +  +L+ E+ R+L   +R +   L++   +QQ+Q+++ L    ++    G 
Sbjct: 939  QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 998

Query: 558  AQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 597
             +   E      +  + +Q  +++      AR+   ++ H
Sbjct: 999  TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1038



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 69/249 (27%), Positives = 120/249 (48%), Gaps = 25/249 (10%)

Query: 390 AKQRREREEREKQRALEQGR-----RAWAAQVEERRGRRGREEREAARRRQRQYERSEER 444
           A ++ ++ E+ K   LEQ R     RA   + E +R    R ++E   RRQ++ ER    
Sbjct: 722 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 781

Query: 445 RRELAER--QGLLRRER----AERAAREDRLRKLQQE--QNLKQREEGLQEGRERAEQIR 496
             ELA R  +  LRR+R    A R  RE+  R+ Q+E  + L++R    +E R++ E +R
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 841

Query: 497 RERAQRAARAKQRQEGQLQREKREL---SRAERARHEALLQGRTRQQRQEREGL---RSS 550
           ++  + A  A++ +E Q + E+  L     A R RHE   + R   + Q ++ L   R  
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901

Query: 551 LEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRS 610
            + +L R Q+  +   +  +++     T  ++S   + +S A  S    +K+ EE     
Sbjct: 902 QQEALRRLQQQQQQQQLA-QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER---- 956

Query: 611 FDRMVREAQ 619
            +R +RE Q
Sbjct: 957 -ERQLREEQ 964



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 50/235 (21%), Positives = 108/235 (45%), Gaps = 11/235 (4%)

Query: 330  QTAQHVERIVRQVRAERGLRGVPE--RDRKIAALMLARHQEELLLLEQRAAAHGQWELQR 387
            Q  + + R+  + R E   R   E  R ++  A   AR +EE     +      + E  R
Sbjct: 815  QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 874

Query: 388  V-HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYER-SEERR 445
            + H ++ R+R+E E QR  E  R+    Q   RR ++ +++++ A+ +        ++  
Sbjct: 875  LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 934

Query: 446  RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE--EGLQEGRERAEQIRRERAQRA 503
                + Q  L     ++   E+R R+L++EQ  +QRE  + LQ+ +++ +Q +       
Sbjct: 935  TTACQSQATLSLAEIQK-LEEERERQLREEQRRQQRELMKALQQQQQQQQQ-KLSGWGNV 992

Query: 504  ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRA 558
            ++     +  L+ ++ E  + ++ + +   Q + +Q  + R    S+L  S+G +
Sbjct: 993  SKPSGTTKSLLEIQQEEARQMQKQQQQ---QQQHQQPNRARNNTHSNLHTSIGNS 1044


>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 86.3 bits (212), Expect = 8e-17
 Identities = 78/244 (31%), Positives = 119/244 (48%), Gaps = 31/244 (12%)

Query: 368 EELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRAL-EQGRRAWAAQVEERRGRRGRE 426
           E+L  LE+  AA  + E +    + +RE EER++Q  L  Q       Q EE R RR  E
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 783

Query: 427 E-----REAARRRQRQYERSEERRRELAERQGL---------LRRERAERAAREDRLRKL 472
           E     +E A RRQR+ E +  R+RE  ERQ            RRE  ER  +E+ LRK 
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 843

Query: 473 QQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQRE-----KRELSRAERA 527
           ++E     REE  +E + R E+ R    + AAR +  +E + ++E     ++EL R  + 
Sbjct: 844 EEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901

Query: 528 RHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-------HLAIGRKL--ERSEQLT 578
           + EAL + + +QQ+Q+   ++    ++ G+              LA  +KL  ER  QL 
Sbjct: 902 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 961

Query: 579 RERR 582
            E+R
Sbjct: 962 EEQR 965



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 77/280 (27%), Positives = 127/280 (45%), Gaps = 20/280 (7%)

Query: 333  QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQE-ELLLLEQRAAAHGQWELQRVHA- 390
            Q  E + RQ   ER  R   E  R+     L R +E E+ L  QR     Q + + +   
Sbjct: 764  QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 823

Query: 391  -KQRREREEREKQRAL----EQGRRAWAAQVEERRGR----RGREEREAARRRQRQYERS 441
             ++RRE EER KQ  L    E+    WA + EE + R    R R E EAAR R   +E  
Sbjct: 824  EERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR---HEEE 880

Query: 442  EERRREL-AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERA 500
            E +R+EL  +RQ  L R+R ++     RL++ QQ+Q L Q +  L       +Q      
Sbjct: 881  ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK--LPSSSTWGQQSNTTAC 938

Query: 501  QRAARAKQRQEGQLQREK-RELSRAERARHEALLQGRTRQQRQEREGLR--SSLEASLGR 557
            Q  A     +  +L+ E+ R+L   +R +   L++   +QQ+Q+++ L    ++    G 
Sbjct: 939  QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 998

Query: 558  AQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 597
             +   E      +  + +Q  +++      AR+   ++ H
Sbjct: 999  TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1038



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 69/249 (27%), Positives = 120/249 (48%), Gaps = 25/249 (10%)

Query: 390 AKQRREREEREKQRALEQGR-----RAWAAQVEERRGRRGREEREAARRRQRQYERSEER 444
           A ++ ++ E+ K   LEQ R     RA   + E +R    R ++E   RRQ++ ER    
Sbjct: 722 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 781

Query: 445 RRELAER--QGLLRRER----AERAAREDRLRKLQQE--QNLKQREEGLQEGRERAEQIR 496
             ELA R  +  LRR+R    A R  RE+  R+ Q+E  + L++R    +E R++ E +R
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 841

Query: 497 RERAQRAARAKQRQEGQLQREKREL---SRAERARHEALLQGRTRQQRQEREGL---RSS 550
           ++  + A  A++ +E Q + E+  L     A R RHE   + R   + Q ++ L   R  
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901

Query: 551 LEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRS 610
            + +L R Q+  +   +  +++     T  ++S   + +S A  S    +K+ EE     
Sbjct: 902 QQEALRRLQQQQQQQQLA-QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER---- 956

Query: 611 FDRMVREAQ 619
            +R +RE Q
Sbjct: 957 -ERQLREEQ 964



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 50/235 (21%), Positives = 108/235 (45%), Gaps = 11/235 (4%)

Query: 330  QTAQHVERIVRQVRAERGLRGVPE--RDRKIAALMLARHQEELLLLEQRAAAHGQWELQR 387
            Q  + + R+  + R E   R   E  R ++  A   AR +EE     +      + E  R
Sbjct: 815  QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 874

Query: 388  V-HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYER-SEERR 445
            + H ++ R+R+E E QR  E  R+    Q   RR ++ +++++ A+ +        ++  
Sbjct: 875  LRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSN 934

Query: 446  RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE--EGLQEGRERAEQIRRERAQRA 503
                + Q  L     ++   E+R R+L++EQ  +QRE  + LQ+ +++ +Q +       
Sbjct: 935  TTACQSQATLSLAEIQK-LEEERERQLREEQRRQQRELMKALQQQQQQQQQ-KLSGWGNV 992

Query: 504  ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRA 558
            ++     +  L+ ++ E  + ++ + +   Q + +Q  + R    S+L  S+G +
Sbjct: 993  SKPSGTTKSLLEIQQEEARQMQKQQQQ---QQQHQQPNRARNNTHSNLHTSIGNS 1044


>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 202

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 55/178 (30%), Positives = 93/178 (52%), Gaps = 5/178 (2%)

Query: 384 ELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEE 443
           E +R   ++R  + ERE +       R    Q +  + R  ++ER+  R+R+R+ ER  E
Sbjct: 18  ERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQRQRERETERETE 77

Query: 444 RRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRA 503
           R+RE   ++   R+   ER    DR RK + ++N   RE   + GRER +Q  RER +  
Sbjct: 78  RQRERQRQRERKRQTDRERDKDRDRERKRETDRN---RERNRKGGRERDKQTERERDRER 134

Query: 504 ARAKQRQ-EGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQE 560
            R +QR+ E Q QRE++  +  ER R  A  + R +++++ER+  R   +    R ++
Sbjct: 135 ERQRQRERERQRQRERKRETDRERQRW-AEREERKKERKKERKKERKEKKKEEKRRED 191



 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 61/208 (29%), Positives = 99/208 (47%), Gaps = 18/208 (8%)

Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
           R+   +RG     ERDR+       R +E     E R   H Q +  R   +Q    +ER
Sbjct: 7   RKRETDRGKETERERDRQ-------RERENQTERENR---HRQRDRHRERDRQTDREKER 56

Query: 400 EKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRRELAERQGLLRRE 458
           E+Q+  E+ R+    +  ER   R RE +R+  R+RQ   ER ++R RE  +R+    RE
Sbjct: 57  ERQK--ERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRE-RKRETDRNRE 113

Query: 459 RAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREK 518
           R  +  RE    + +Q +  + RE   Q  RER  Q +RER +   R +QR   + +R+K
Sbjct: 114 RNRKGGRE----RDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKK 169

Query: 519 RELSRAERARHEALLQGRTRQQRQEREG 546
                 ++ R E   + + R+ ++ + G
Sbjct: 170 ERKKERKKERKEKKKEEKRREDKKRKWG 197



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 53/192 (27%), Positives = 87/192 (45%), Gaps = 6/192 (3%)

Query: 392 QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAER 451
           +R+   +RE  R  E  R     +  ER  +  RE R   R R R+ +R  +R +   ER
Sbjct: 2   ERQRERKRETDRGKETERE--RDRQRERENQTERENRHRQRDRHRERDRQTDREK---ER 56

Query: 452 QGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR-Q 510
           +    R+R  +  RE      +Q +  +QRE   Q  RER +   RER +   R ++R +
Sbjct: 57  ERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNR 116

Query: 511 EGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRK 570
           +G  +R+K+     +R R     + R RQ+++ER+             +E  +     RK
Sbjct: 117 KGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERK 176

Query: 571 LERSEQLTRERR 582
            ER E+   E+R
Sbjct: 177 KERKEKKKEEKR 188



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 51/195 (26%), Positives = 83/195 (42%), Gaps = 9/195 (4%)

Query: 416 VEERRGRRGREEREAARRRQRQYERSEERR--RELAERQGLLRRERAERAAREDRLRKLQ 473
           +E +R R+   +R     R+R  +R  E +  RE   RQ    RER  +  RE    + +
Sbjct: 1   MERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQK 60

Query: 474 QEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALL 533
           +    +QRE   +   ER  + +R+R ++    ++R + + +  KRE    +R R     
Sbjct: 61  ERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRE---TDRNRERNRK 117

Query: 534 QGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQL---TRERRSALESARS 590
            GR R ++ ERE  R   E    R +E        R+ +R  Q      ER+   +  R 
Sbjct: 118 GGRERDKQTERERDRER-ERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERK 176

Query: 591 TARASFHVREKVREE 605
             R      EK RE+
Sbjct: 177 KERKEKKKEEKRRED 191



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 53/178 (29%), Positives = 75/178 (42%), Gaps = 24/178 (13%)

Query: 434 RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
           RQR+ +R  +R +E  ER+   +RER  +  RE+R R+  +              RER  
Sbjct: 3   RQRERKRETDRGKE-TERERDRQRERENQTERENRHRQRDRH-------------RERDR 48

Query: 494 QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
           Q  RE+ +   + + RQ    QRE+      ER R     + R RQ  +ER+  R     
Sbjct: 49  QTDREKERERQKERDRQR---QRERETERETERQRERQRQRERKRQTDRERDKDRDR--- 102

Query: 554 SLGRAQENYEHLAIGRK--LERSEQLTRERRSALESARSTARASFHVREKVREETNTR 609
              R +E   +    RK   ER +Q  RER    E  R   R     RE+ RE    R
Sbjct: 103 --ERKRETDRNRERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRER 158



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 46/178 (25%), Positives = 75/178 (42%), Gaps = 36/178 (20%)

Query: 330 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 389
           Q  +H ER  RQ   E+      ERDR+       R +E     E       Q E QR  
Sbjct: 39  QRDRHRERD-RQTDREKERERQKERDRQ-------RQRER----ETERETERQRERQRQR 86

Query: 390 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE-------------------EREA 430
            ++R+   ER+K R  E+ R     +   R+G R R+                   ER+ 
Sbjct: 87  ERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTERERDRERERQRQRERERQR 146

Query: 431 ARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG 488
            R R+R+ +R  +R  E  ER+   ++ER     +++R  K ++E+  + ++    EG
Sbjct: 147 QRERKRETDRERQRWAEREERKKERKKER-----KKERKEKKKEEKRREDKKRKWGEG 199


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 57/237 (24%), Positives = 119/237 (50%), Gaps = 24/237 (10%)

Query: 373 LEQRAAAHGQWELQRV------------HAKQRREREEREKQRALEQGRRAWAAQVEERR 420
           +  RAA     ELQ V             +++++ER EREK++   +  R      +E++
Sbjct: 5   ISSRAAVKLNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKK 64

Query: 421 GRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQ 480
            R+ RE  +   R++++ E+  + RRE   R+    +++ ER  R  R RK ++E+  K+
Sbjct: 65  KRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKER--KE 122

Query: 481 REEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ 540
           RE   ++ RER  + RR++ +R  R ++++ G+ +R++++  + ER +     + R R++
Sbjct: 123 RERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKK----RERNRKE 178

Query: 541 RQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 597
           R++    +   E    R +E        +K ER +    +R++  +  R    ++F+
Sbjct: 179 RKKERERKERRERKKERKKER------RKKKERKKDRKTDRQTDSQVFRPLRESAFN 229



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 51/198 (25%), Positives = 104/198 (52%), Gaps = 9/198 (4%)

Query: 418 ERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQN 477
           +R   R +E RE   R +R+ ER +ER+RE  +++   R++R ER    +R RK +++Q 
Sbjct: 31  QRESERKKERRE---REKRKREREKERKRERGKKEKKKRKKR-ERGKERERKRKEREKQR 86

Query: 478 LKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRT 537
            ++RE+  +  + + E+ +RER QR  R +++++ + +RE+    R ER R +   + R 
Sbjct: 87  KERREK--ERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRR 144

Query: 538 RQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFH 597
           +++++E+E  +   +    + +E  +     RK  + E+  +ERR   +  +   R    
Sbjct: 145 KERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKK-- 202

Query: 598 VREKVREETNTRSFDRMV 615
            +E+ ++    R  D  V
Sbjct: 203 -KERKKDRKTDRQTDSQV 219



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 44/193 (22%), Positives = 88/193 (45%), Gaps = 13/193 (6%)

Query: 439 ERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRE 498
           +R  ER++E        RRER +R    ++ RK ++ +  K++ +  + G+ER E+ R+E
Sbjct: 31  QRESERKKE--------RREREKRKREREKERKRERGKKEKKKRKKRERGKER-ERKRKE 81

Query: 499 RAQRAARAKQRQEGQLQREKRELSRAERARHEAL----LQGRTRQQRQEREGLRSSLEAS 554
           R ++    ++++  + ++EK++  R +R R E       + R R+ +Q RE  R      
Sbjct: 82  REKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKK 141

Query: 555 LGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRM 614
             R +   E     R+ +R ++   ER    E  R   +     +E+   +   +   R 
Sbjct: 142 KRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRK 201

Query: 615 VREAQLHASLDRK 627
            +E +     DR+
Sbjct: 202 KKERKKDRKTDRQ 214



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 42/186 (22%), Positives = 95/186 (51%), Gaps = 17/186 (9%)

Query: 340 RQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
           ++ + ERG +   +R ++       R ++E    +QR     +   +R   K++RER++R
Sbjct: 52  KERKRERGKKEKKKRKKRERGKERERKRKERE--KQRKERREKERRKRKKEKKKRERKQR 109

Query: 400 ----EKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLL 455
                K++   + R     Q  ER+ ++ R+++    R++ +     ER+R+        
Sbjct: 110 GRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRK-------- 161

Query: 456 RRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQ-EGQL 514
           +R++ ER  + +R RK ++++  ++R+E  +  +ER ++ R+++ ++  R   RQ + Q+
Sbjct: 162 KRKKEEREKKRERNRKERKKE--RERKERRERKKERKKERRKKKERKKDRKTDRQTDSQV 219

Query: 515 QREKRE 520
            R  RE
Sbjct: 220 FRPLRE 225


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)

Query: 155  EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
            +AER AK  Q R + E + REE        KR +   L     ++ A   A A  A +  
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1442

Query: 207  SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
                       A R+  +        R Q      + G     L +L  R E A + +  
Sbjct: 1443 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491

Query: 267  ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
            A   +         ES R+ +     ++R    A +A     A      L L      R 
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1551

Query: 320  FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
                ++  + Q    +E   R   AE   +     + K A L  +  +E + + + R  A
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1610

Query: 380  HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
              + + Q+  A++ RE  ERE +R   +   A   +++     + +   +A   +Q++  
Sbjct: 1611 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669

Query: 440  RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
              E RRR  AE Q + +RE AE+   + R        ++L  EQ L     + E+G Q+ 
Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1729

Query: 489  RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
            +   E++ R + + AA  ++RQE + +  K       RA  E LL  + R + + R   E
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1783

Query: 546  GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
              +  LEA  GR +E  E  A  R L  +E+  R+R+ A E +AR  A A   + EK+
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)

Query: 53   EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
            E  A   S + + A  +K E    A   G+ E+  +   +L   +  +    AEG+    
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708

Query: 109  TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
             +       L A      +  +LL   LA L REA   + +           E  A+L +
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1759

Query: 165  CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
             RAE E ++  + R         + +  +     A +         A+   + A  A R+
Sbjct: 1760 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816

Query: 225  ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
               +   A  Q   A      K  ++   +R +  A   E          E LR L    
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 1872

Query: 285  RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
             A  R      +A    +   R + L     +      G +  + +  + VE  +  ++A
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1932

Query: 345  --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
              E+   G  E + ++  +    + E+ L  +++A   A  Q +L     ++RRE EE  
Sbjct: 1933 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1990

Query: 399  -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
                       R+++ ALE+  R   A+VEE R  R R E+E+AR+ Q   E +++R   
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2046

Query: 448  LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
                  L   E+A   A + + ++LQ  Q L+Q +  L + R  AE  RR  A+ A  A+
Sbjct: 2047 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2097

Query: 508  QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
             + E +  + +R++  AER +  A  Q + R Q Q   E LR   E    R +   E  A
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2156

Query: 567  IGRKLERSEQLTRERRSALESARSTAR 593
            + +K     ++ + ++ A ++ R  A+
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2183



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)

Query: 155  EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
            E ER +AK+++ R  RER  +E  R+L      A     A   A A +          +L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069

Query: 214  PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
                +          AAR+A+     AR Q     +++ R+    + L +  E    + +
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129

Query: 266  GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
             A +++       E     RA A  +      ++               R  A     +T
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189

Query: 317  GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
                 L +  H       ++  +++++AE       +R +    L   R Q EEL  L+ 
Sbjct: 2190 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2245

Query: 376  RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
            R  A  +  + R     QR  +EE EK +           QV E   R     +EAAR R
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2294

Query: 435  QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
            Q            LAE     +R  AE+  +E +++ +Q+   LK   E LQ+ +E A+ 
Sbjct: 2295 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2340

Query: 495  IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
               E+A+R    K++   QL  E +   R   A        R RQ     E  R  L  A
Sbjct: 2341 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2390

Query: 554  SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
             + RAQ   E  A         IG KL R+E  T+E+ + +++     + S H  E++RE
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450

Query: 605  ETN--TRSFDRMVREAQL 620
                  R  +++ +EA+L
Sbjct: 2451 AIAELEREKEKLQQEAKL 2468



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)

Query: 325  LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
            +S + +  +  ER+  Q RAE       ER+R      LA  +  L    Q A AH Q  
Sbjct: 1337 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1381

Query: 385  LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
                 AK + ERE +E Q+ +++   RR  AA   +++ R  +EE +  R+      +++
Sbjct: 1382 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436

Query: 443  ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
             R+ E AER  L          L+ E  ER               A E   +K Q ++  
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496

Query: 479  KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
            ++    +Q+  +R  Q   E A R      AAR KQR    L+  + +   AER   +A 
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556

Query: 533  LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
            ++ R RQ +   E  + S EA L   + ++             EH+A+ +  E    R++
Sbjct: 1557 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
            Q     R+  E+ R   R      E +R         +    AQ  A   ++
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)

Query: 330  QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
            Q A   ER  R+   R ++ L    E  R RK A   + R +   EE   L +RA     
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033

Query: 383  WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
             +LQ     A++R + EE+       +K++ L+Q  +   + +++ RG     E EAARR
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2088

Query: 434  RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
                 E +EE R + AER+    R + E A R         +Q+ +++ +   + +  AE
Sbjct: 2089 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2136

Query: 494  QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
            ++R+E  Q AAR  Q ++  L+  +++ + AE  +H+   +   RQ+ Q  + L      
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2189

Query: 554  SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
            +L    E  +H    +K    E+L R +  A E+AR  ++     F VR ++ E
Sbjct: 2190 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)

Query: 353  ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
            ++ +++A     R QE+   + Q+ A   Q   + + A+++R+ E     ER K R  E 
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392

Query: 408  GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
             R    A+ + +R R+  EE      R                 QRQ      ER  E  
Sbjct: 2393 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452

Query: 446  RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
             EL   +  L++E      + + ++ +QQEQ L Q  + LQ+    E+   ++RER    
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2511

Query: 504  ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
             +AK  Q  Q      E+++A++ R E   Q + +Q  QER+ L +S+E +  R  E  E
Sbjct: 2512 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2564

Query: 564  HLAIGRKLERSEQLTRERRSALE 586
               + RK E  +QL ++RR   E
Sbjct: 2565 --GVRRKQEELQQLEQQRRQQEE 2585



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)

Query: 336  ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
            E++ +Q+  E +G +   E +R+    M A  +   L + +  RA A  + + QR   KQ
Sbjct: 2351 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2409

Query: 393  RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
              E  E+  +  L    +    Q  E + ++   + E  R    + ER +E+ ++ A+  
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469

Query: 453  GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
             L + E  +   +E  L++ Q        ++ +L QRE  +++ + + EQ+ ++   +AQ
Sbjct: 2470 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2528

Query: 502  RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
            +    +QRQ+ Q+++E++ L      A R +HEA    R +Q+  Q+ E  R   E  L 
Sbjct: 2529 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2587

Query: 557  RAQENYEHLAIGRKLERSEQLTRERRSAL 585
             A+EN       R  E+ + L  + R+AL
Sbjct: 2588 -AEENQ------RLREQLQLLEEQHRAAL 2609



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)

Query: 367  QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
            Q E  + +++A     ++ +   A+Q RE ++R+ Q+ +EQ R+   A +EE R RR  E
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2561

Query: 427  EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
              E  RR+Q + ++ E++RR+    LAE    LR      E   RAA     E    ++ 
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621

Query: 474  QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
              + L    + L      AE         R+  AQR   A      +LQR  +      E
Sbjct: 2622 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2681

Query: 521  LSRAERARHEALLQGRT 537
            L+R E  RH   LQGR+
Sbjct: 2682 LARREDVRH--YLQGRS 2696



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)

Query: 24   EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
            EE +  AE   +     V       Q A+E A + A A A+A   RK E    AA   + 
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2152

Query: 84   EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
            EQ+ L      + +  +            A+  + + T    LE          E L R 
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2212

Query: 132  LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
             A+    A  RS            M   + L    EAE RA + + +   +R ++EE  +
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272

Query: 180  LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
            +      AA  + AA  A+     +    +     A         A + A +        
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332

Query: 233  RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
            + Q   A  +  R     + ++++    L+ E+     +   E  R+L            
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2388

Query: 285  -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
                 RA AR    A          G     T +    +   +  L    Q + H    +
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448

Query: 340  RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
            R+  AE  L    E+ ++ A L+  + +E      E LL E +A    Q  L    +  +
Sbjct: 2449 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2504

Query: 394  REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
            RER   +++  LEQ  +   A+ ++ R  + R++++  + RQR     EE RR       
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2557

Query: 454  LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
                            R+ + E+ +++++E LQ+     EQ RR++ +  A   QR   Q
Sbjct: 2558 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2597

Query: 514  LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
            LQ    E  RA  A  E +   +    +    G R +L+     A+  +    + RK+  
Sbjct: 2598 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2654

Query: 574  SEQLTRERRSALESARSTARASFHVREKVREE 605
            +++L      + E  +  A+    V E  R E
Sbjct: 2655 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2686



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)

Query: 331  TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
            +A ++E++       RG +G  E        +L  H+E+L   E +A      EL+   A
Sbjct: 1081 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1130

Query: 391  KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
              ++ R + E Q+      R      +E RG +   ER     +QR  ER  E  R    
Sbjct: 1131 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1180

Query: 451  RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
               LL R +A  A  + R R+L+Q                   Q+ ++R+E +Q     +
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240

Query: 488  GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
             +   EQ+R+E+A               QR A+    A +  E QL   K +L       
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1300

Query: 529  HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
             +  +Q  +    QE   LR+                +   R  E  E LA  ++ E  E
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1360

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
            +L  E  +ALE  R  A A  H + K + E   +   + ++E
Sbjct: 1361 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1399


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)

Query: 155  EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
            +AER AK  Q R + E + REE        KR +   L     ++ A   A A  A +  
Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1446

Query: 207  SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
                       A R+  +        R Q      + G     L +L  R E A + +  
Sbjct: 1447 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1495

Query: 267  ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
            A   +         ES R+ +     ++R    A +A     A      L L      R 
Sbjct: 1496 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1555

Query: 320  FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
                ++  + Q    +E   R   AE   +     + K A L  +  +E + + + R  A
Sbjct: 1556 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1614

Query: 380  HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
              + + Q+  A++ RE  ERE +R   +   A   +++     + +   +A   +Q++  
Sbjct: 1615 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1673

Query: 440  RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
              E RRR  AE Q + +RE AE+   + R        ++L  EQ L     + E+G Q+ 
Sbjct: 1674 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1733

Query: 489  RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
            +   E++ R + + AA  ++RQE + +  K       RA  E LL  + R + + R   E
Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1787

Query: 546  GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
              +  LEA  GR +E  E  A  R L  +E+  R+R+ A E +AR  A A   + EK+
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1843



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)

Query: 53   EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
            E  A   S + + A  +K E    A   G+ E+  +   +L   +  +    AEG+    
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1712

Query: 109  TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
             +       L A      +  +LL   LA L REA   + +           E  A+L +
Sbjct: 1713 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1763

Query: 165  CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
             RAE E ++  + R         + +  +     A +         A+   + A  A R+
Sbjct: 1764 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1820

Query: 225  ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
               +   A  Q   A      K  ++   +R +  A   E          E LR L    
Sbjct: 1821 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 1876

Query: 285  RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
             A  R      +A    +   R + L     +      G +  + +  + VE  +  ++A
Sbjct: 1877 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1936

Query: 345  --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
              E+   G  E + ++  +    + E+ L  +++A   A  Q +L     ++RRE EE  
Sbjct: 1937 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1994

Query: 399  -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
                       R+++ ALE+  R   A+VEE R  R R E+E+AR+ Q   E +++R   
Sbjct: 1995 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2050

Query: 448  LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
                  L   E+A   A + + ++LQ  Q L+Q +  L + R  AE  RR  A+ A  A+
Sbjct: 2051 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2101

Query: 508  QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
             + E +  + +R++  AER +  A  Q + R Q Q   E LR   E    R +   E  A
Sbjct: 2102 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2160

Query: 567  IGRKLERSEQLTRERRSALESARSTAR 593
            + +K     ++ + ++ A ++ R  A+
Sbjct: 2161 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2187



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)

Query: 155  EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
            E ER +AK+++ R  RER  +E  R+L      A     A   A A +          +L
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2073

Query: 214  PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
                +          AAR+A+     AR Q     +++ R+    + L +  E    + +
Sbjct: 2074 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2133

Query: 266  GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
             A +++       E     RA A  +      ++               R  A     +T
Sbjct: 2134 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2193

Query: 317  GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
                 L +  H       ++  +++++AE       +R +    L   R Q EEL  L+ 
Sbjct: 2194 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2249

Query: 376  RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
            R  A  +  + R     QR  +EE EK +           QV E   R     +EAAR R
Sbjct: 2250 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2298

Query: 435  QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
            Q            LAE     +R  AE+  +E +++ +Q+   LK   E LQ+ +E A+ 
Sbjct: 2299 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2344

Query: 495  IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
               E+A+R    K++   QL  E +   R   A        R RQ     E  R  L  A
Sbjct: 2345 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2394

Query: 554  SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
             + RAQ   E  A         IG KL R+E  T+E+ + +++     + S H  E++RE
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454

Query: 605  ETN--TRSFDRMVREAQL 620
                  R  +++ +EA+L
Sbjct: 2455 AIAELEREKEKLQQEAKL 2472



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)

Query: 325  LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
            +S + +  +  ER+  Q RAE       ER+R      LA  +  L    Q A AH Q  
Sbjct: 1341 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1385

Query: 385  LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
                 AK + ERE +E Q+ +++   RR  AA   +++ R  +EE +  R+      +++
Sbjct: 1386 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1440

Query: 443  ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
             R+ E AER  L          L+ E  ER               A E   +K Q ++  
Sbjct: 1441 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1500

Query: 479  KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
            ++    +Q+  +R  Q   E A R      AAR KQR    L+  + +   AER   +A 
Sbjct: 1501 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1560

Query: 533  LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
            ++ R RQ +   E  + S EA L   + ++             EH+A+ +  E    R++
Sbjct: 1561 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1619

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
            Q     R+  E+ R   R      E +R         +    AQ  A   ++
Sbjct: 1620 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1671



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)

Query: 330  QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
            Q A   ER  R+   R ++ L    E  R RK A   + R +   EE   L +RA     
Sbjct: 1978 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2037

Query: 383  WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
             +LQ     A++R + EE+       +K++ L+Q  +   + +++ RG     E EAARR
Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2092

Query: 434  RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
                 E +EE R + AER+    R + E A R         +Q+ +++ +   + +  AE
Sbjct: 2093 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2140

Query: 494  QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
            ++R+E  Q AAR  Q ++  L+  +++ + AE  +H+   +   RQ+ Q  + L      
Sbjct: 2141 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2193

Query: 554  SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
            +L    E  +H    +K    E+L R +  A E+AR  ++     F VR ++ E
Sbjct: 2194 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)

Query: 353  ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
            ++ +++A     R QE+   + Q+ A   Q   + + A+++R+ E     ER K R  E 
Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2396

Query: 408  GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
             R    A+ + +R R+  EE      R                 QRQ      ER  E  
Sbjct: 2397 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2456

Query: 446  RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
             EL   +  L++E      + + ++ +QQEQ L Q  + LQ+    E+   ++RER    
Sbjct: 2457 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2515

Query: 504  ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
             +AK  Q  Q      E+++A++ R E   Q + +Q  QER+ L +S+E +  R  E  E
Sbjct: 2516 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2568

Query: 564  HLAIGRKLERSEQLTRERRSALE 586
               + RK E  +QL ++RR   E
Sbjct: 2569 --GVRRKQEELQQLEQQRRQQEE 2589



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)

Query: 336  ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
            E++ +Q+  E +G +   E +R+    M A  +   L + +  RA A  + + QR   KQ
Sbjct: 2355 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2413

Query: 393  RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
              E  E+  +  L    +    Q  E + ++   + E  R    + ER +E+ ++ A+  
Sbjct: 2414 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2473

Query: 453  GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
             L + E  +   +E  L++ Q        ++ +L QRE  +++ + + EQ+ ++   +AQ
Sbjct: 2474 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2532

Query: 502  RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
            +    +QRQ+ Q+++E++ L      A R +HEA    R +Q+  Q+ E  R   E  L 
Sbjct: 2533 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2591

Query: 557  RAQENYEHLAIGRKLERSEQLTRERRSAL 585
             A+EN       R  E+ + L  + R+AL
Sbjct: 2592 -AEENQ------RLREQLQLLEEQHRAAL 2613



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)

Query: 367  QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
            Q E  + +++A     ++ +   A+Q RE ++R+ Q+ +EQ R+   A +EE R RR  E
Sbjct: 2508 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2565

Query: 427  EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
              E  RR+Q + ++ E++RR+    LAE    LR      E   RAA     E    ++ 
Sbjct: 2566 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2625

Query: 474  QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
              + L    + L      AE         R+  AQR   A      +LQR  +      E
Sbjct: 2626 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2685

Query: 521  LSRAERARHEALLQGRT 537
            L+R E  RH   LQGR+
Sbjct: 2686 LARREDVRH--YLQGRS 2700



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)

Query: 24   EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
            EE +  AE   +     V       Q A+E A + A A A+A   RK E    AA   + 
Sbjct: 2098 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2156

Query: 84   EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
            EQ+ L      + +  +            A+  + + T    LE          E L R 
Sbjct: 2157 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2216

Query: 132  LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
             A+    A  RS            M   + L    EAE RA + + +   +R ++EE  +
Sbjct: 2217 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2276

Query: 180  LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
            +      AA  + AA  A+     +    +     A         A + A +        
Sbjct: 2277 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2336

Query: 233  RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
            + Q   A  +  R     + ++++    L+ E+     +   E  R+L            
Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2392

Query: 285  -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
                 RA AR    A          G     T +    +   +  L    Q + H    +
Sbjct: 2393 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2452

Query: 340  RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
            R+  AE  L    E+ ++ A L+  + +E      E LL E +A    Q  L    +  +
Sbjct: 2453 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2508

Query: 394  REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
            RER   +++  LEQ  +   A+ ++ R  + R++++  + RQR     EE RR       
Sbjct: 2509 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2561

Query: 454  LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
                            R+ + E+ +++++E LQ+     EQ RR++ +  A   QR   Q
Sbjct: 2562 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2601

Query: 514  LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
            LQ    E  RA  A  E +   +    +    G R +L+     A+  +    + RK+  
Sbjct: 2602 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2658

Query: 574  SEQLTRERRSALESARSTARASFHVREKVREE 605
            +++L      + E  +  A+    V E  R E
Sbjct: 2659 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2690



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)

Query: 331  TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
            +A ++E++       RG +G  E        +L  H+E+L   E +A      EL+   A
Sbjct: 1085 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1134

Query: 391  KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
              ++ R + E Q+      R      +E RG +   ER     +QR  ER  E  R    
Sbjct: 1135 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1184

Query: 451  RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
               LL R +A  A  + R R+L+Q                   Q+ ++R+E +Q     +
Sbjct: 1185 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1244

Query: 488  GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
             +   EQ+R+E+A               QR A+    A +  E QL   K +L       
Sbjct: 1245 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1304

Query: 529  HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
             +  +Q  +    QE   LR+                +   R  E  E LA  ++ E  E
Sbjct: 1305 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1364

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
            +L  E  +ALE  R  A A  H + K + E   +   + ++E
Sbjct: 1365 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1403


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)

Query: 155  EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
            +AER AK  Q R + E + REE        KR +   L     ++ A   A A  A +  
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1442

Query: 207  SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
                       A R+  +        R Q      + G     L +L  R E A + +  
Sbjct: 1443 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491

Query: 267  ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
            A   +         ES R+ +     ++R    A +A     A      L L      R 
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1551

Query: 320  FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
                ++  + Q    +E   R   AE   +     + K A L  +  +E + + + R  A
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1610

Query: 380  HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
              + + Q+  A++ RE  ERE +R   +   A   +++     + +   +A   +Q++  
Sbjct: 1611 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669

Query: 440  RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
              E RRR  AE Q + +RE AE+   + R        ++L  EQ L     + E+G Q+ 
Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1729

Query: 489  RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
            +   E++ R + + AA  ++RQE + +  K       RA  E LL  + R + + R   E
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1783

Query: 546  GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
              +  LEA  GR +E  E  A  R L  +E+  R+R+ A E +AR  A A   + EK+
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)

Query: 53   EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
            E  A   S + + A  +K E    A   G+ E+  +   +L   +  +    AEG+    
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708

Query: 109  TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
             +       L A      +  +LL   LA L REA   + +           E  A+L +
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1759

Query: 165  CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
             RAE E ++  + R         + +  +     A +         A+   + A  A R+
Sbjct: 1760 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816

Query: 225  ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
               +   A  Q   A      K  ++   +R +  A   E          E LR L    
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 1872

Query: 285  RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
             A  R      +A    +   R + L     +      G +  + +  + VE  +  ++A
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1932

Query: 345  --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
              E+   G  E + ++  +    + E+ L  +++A   A  Q +L     ++RRE EE  
Sbjct: 1933 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1990

Query: 399  -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
                       R+++ ALE+  R   A+VEE R  R R E+E+AR+ Q   E +++R   
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2046

Query: 448  LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
                  L   E+A   A + + ++LQ  Q L+Q +  L + R  AE  RR  A+ A  A+
Sbjct: 2047 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2097

Query: 508  QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
             + E +  + +R++  AER +  A  Q + R Q Q   E LR   E    R +   E  A
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2156

Query: 567  IGRKLERSEQLTRERRSALESARSTAR 593
            + +K     ++ + ++ A ++ R  A+
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2183



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)

Query: 155  EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
            E ER +AK+++ R  RER  +E  R+L      A     A   A A +          +L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069

Query: 214  PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
                +          AAR+A+     AR Q     +++ R+    + L +  E    + +
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129

Query: 266  GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
             A +++       E     RA A  +      ++               R  A     +T
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189

Query: 317  GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
                 L +  H       ++  +++++AE       +R +    L   R Q EEL  L+ 
Sbjct: 2190 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2245

Query: 376  RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
            R  A  +  + R     QR  +EE EK +           QV E   R     +EAAR R
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2294

Query: 435  QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
            Q            LAE     +R  AE+  +E +++ +Q+   LK   E LQ+ +E A+ 
Sbjct: 2295 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2340

Query: 495  IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
               E+A+R    K++   QL  E +   R   A        R RQ     E  R  L  A
Sbjct: 2341 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2390

Query: 554  SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
             + RAQ   E  A         IG KL R+E  T+E+ + +++     + S H  E++RE
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450

Query: 605  ETN--TRSFDRMVREAQL 620
                  R  +++ +EA+L
Sbjct: 2451 AIAELEREKEKLQQEAKL 2468



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)

Query: 325  LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
            +S + +  +  ER+  Q RAE       ER+R      LA  +  L    Q A AH Q  
Sbjct: 1337 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1381

Query: 385  LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
                 AK + ERE +E Q+ +++   RR  AA   +++ R  +EE +  R+      +++
Sbjct: 1382 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436

Query: 443  ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
             R+ E AER  L          L+ E  ER               A E   +K Q ++  
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496

Query: 479  KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
            ++    +Q+  +R  Q   E A R      AAR KQR    L+  + +   AER   +A 
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556

Query: 533  LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
            ++ R RQ +   E  + S EA L   + ++             EH+A+ +  E    R++
Sbjct: 1557 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
            Q     R+  E+ R   R      E +R         +    AQ  A   ++
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)

Query: 330  QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
            Q A   ER  R+   R ++ L    E  R RK A   + R +   EE   L +RA     
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033

Query: 383  WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
             +LQ     A++R + EE+       +K++ L+Q  +   + +++ RG     E EAARR
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2088

Query: 434  RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
                 E +EE R + AER+    R + E A R         +Q+ +++ +   + +  AE
Sbjct: 2089 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2136

Query: 494  QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
            ++R+E  Q AAR  Q ++  L+  +++ + AE  +H+   +   RQ+ Q  + L      
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2189

Query: 554  SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
            +L    E  +H    +K    E+L R +  A E+AR  ++     F VR ++ E
Sbjct: 2190 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)

Query: 353  ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
            ++ +++A     R QE+   + Q+ A   Q   + + A+++R+ E     ER K R  E 
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392

Query: 408  GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
             R    A+ + +R R+  EE      R                 QRQ      ER  E  
Sbjct: 2393 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452

Query: 446  RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
             EL   +  L++E      + + ++ +QQEQ L Q  + LQ+    E+   ++RER    
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2511

Query: 504  ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
             +AK  Q  Q      E+++A++ R E   Q + +Q  QER+ L +S+E +  R  E  E
Sbjct: 2512 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2564

Query: 564  HLAIGRKLERSEQLTRERRSALE 586
               + RK E  +QL ++RR   E
Sbjct: 2565 --GVRRKQEELQQLEQQRRQQEE 2585



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)

Query: 336  ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
            E++ +Q+  E +G +   E +R+    M A  +   L + +  RA A  + + QR   KQ
Sbjct: 2351 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2409

Query: 393  RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
              E  E+  +  L    +    Q  E + ++   + E  R    + ER +E+ ++ A+  
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469

Query: 453  GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
             L + E  +   +E  L++ Q        ++ +L QRE  +++ + + EQ+ ++   +AQ
Sbjct: 2470 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2528

Query: 502  RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
            +    +QRQ+ Q+++E++ L      A R +HEA    R +Q+  Q+ E  R   E  L 
Sbjct: 2529 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2587

Query: 557  RAQENYEHLAIGRKLERSEQLTRERRSAL 585
             A+EN       R  E+ + L  + R+AL
Sbjct: 2588 -AEENQ------RLREQLQLLEEQHRAAL 2609



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)

Query: 367  QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
            Q E  + +++A     ++ +   A+Q RE ++R+ Q+ +EQ R+   A +EE R RR  E
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2561

Query: 427  EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
              E  RR+Q + ++ E++RR+    LAE    LR      E   RAA     E    ++ 
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621

Query: 474  QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
              + L    + L      AE         R+  AQR   A      +LQR  +      E
Sbjct: 2622 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2681

Query: 521  LSRAERARHEALLQGRT 537
            L+R E  RH   LQGR+
Sbjct: 2682 LARREDVRH--YLQGRS 2696



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)

Query: 24   EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
            EE +  AE   +     V       Q A+E A + A A A+A   RK E    AA   + 
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2152

Query: 84   EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
            EQ+ L      + +  +            A+  + + T    LE          E L R 
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2212

Query: 132  LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
             A+    A  RS            M   + L    EAE RA + + +   +R ++EE  +
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272

Query: 180  LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
            +      AA  + AA  A+     +    +     A         A + A +        
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332

Query: 233  RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
            + Q   A  +  R     + ++++    L+ E+     +   E  R+L            
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2388

Query: 285  -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
                 RA AR    A          G     T +    +   +  L    Q + H    +
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448

Query: 340  RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
            R+  AE  L    E+ ++ A L+  + +E      E LL E +A    Q  L    +  +
Sbjct: 2449 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2504

Query: 394  REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
            RER   +++  LEQ  +   A+ ++ R  + R++++  + RQR     EE RR       
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2557

Query: 454  LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
                            R+ + E+ +++++E LQ+     EQ RR++ +  A   QR   Q
Sbjct: 2558 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2597

Query: 514  LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
            LQ    E  RA  A  E +   +    +    G R +L+     A+  +    + RK+  
Sbjct: 2598 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2654

Query: 574  SEQLTRERRSALESARSTARASFHVREKVREE 605
            +++L      + E  +  A+    V E  R E
Sbjct: 2655 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2686



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)

Query: 331  TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
            +A ++E++       RG +G  E        +L  H+E+L   E +A      EL+   A
Sbjct: 1081 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1130

Query: 391  KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
              ++ R + E Q+      R      +E RG +   ER     +QR  ER  E  R    
Sbjct: 1131 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1180

Query: 451  RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
               LL R +A  A  + R R+L+Q                   Q+ ++R+E +Q     +
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240

Query: 488  GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
             +   EQ+R+E+A               QR A+    A +  E QL   K +L       
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1300

Query: 529  HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
             +  +Q  +    QE   LR+                +   R  E  E LA  ++ E  E
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1360

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
            +L  E  +ALE  R  A A  H + K + E   +   + ++E
Sbjct: 1361 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1399


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)

Query: 155  EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
            +AER AK  Q R + E + REE        KR +   L     ++ A   A A  A +  
Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1410

Query: 207  SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
                       A R+  +        R Q      + G     L +L  R E A + +  
Sbjct: 1411 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1459

Query: 267  ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
            A   +         ES R+ +     ++R    A +A     A      L L      R 
Sbjct: 1460 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1519

Query: 320  FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
                ++  + Q    +E   R   AE   +     + K A L  +  +E + + + R  A
Sbjct: 1520 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1578

Query: 380  HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
              + + Q+  A++ RE  ERE +R   +   A   +++     + +   +A   +Q++  
Sbjct: 1579 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1637

Query: 440  RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
              E RRR  AE Q + +RE AE+   + R        ++L  EQ L     + E+G Q+ 
Sbjct: 1638 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1697

Query: 489  RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
            +   E++ R + + AA  ++RQE + +  K       RA  E LL  + R + + R   E
Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1751

Query: 546  GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
              +  LEA  GR +E  E  A  R L  +E+  R+R+ A E +AR  A A   + EK+
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1807



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)

Query: 53   EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
            E  A   S + + A  +K E    A   G+ E+  +   +L   +  +    AEG+    
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1676

Query: 109  TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
             +       L A      +  +LL   LA L REA   + +           E  A+L +
Sbjct: 1677 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1727

Query: 165  CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
             RAE E ++  + R         + +  +     A +         A+   + A  A R+
Sbjct: 1728 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1784

Query: 225  ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
               +   A  Q   A      K  ++   +R +  A   E          E LR L    
Sbjct: 1785 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 1840

Query: 285  RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
             A  R      +A    +   R + L     +      G +  + +  + VE  +  ++A
Sbjct: 1841 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1900

Query: 345  --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
              E+   G  E + ++  +    + E+ L  +++A   A  Q +L     ++RRE EE  
Sbjct: 1901 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1958

Query: 399  -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
                       R+++ ALE+  R   A+VEE R  R R E+E+AR+ Q   E +++R   
Sbjct: 1959 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2014

Query: 448  LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
                  L   E+A   A + + ++LQ  Q L+Q +  L + R  AE  RR  A+ A  A+
Sbjct: 2015 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2065

Query: 508  QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
             + E +  + +R++  AER +  A  Q + R Q Q   E LR   E    R +   E  A
Sbjct: 2066 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2124

Query: 567  IGRKLERSEQLTRERRSALESARSTAR 593
            + +K     ++ + ++ A ++ R  A+
Sbjct: 2125 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2151



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)

Query: 155  EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
            E ER +AK+++ R  RER  +E  R+L      A     A   A A +          +L
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2037

Query: 214  PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
                +          AAR+A+     AR Q     +++ R+    + L +  E    + +
Sbjct: 2038 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2097

Query: 266  GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
             A +++       E     RA A  +      ++               R  A     +T
Sbjct: 2098 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2157

Query: 317  GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
                 L +  H       ++  +++++AE       +R +    L   R Q EEL  L+ 
Sbjct: 2158 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2213

Query: 376  RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
            R  A  +  + R     QR  +EE EK +           QV E   R     +EAAR R
Sbjct: 2214 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2262

Query: 435  QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
            Q            LAE     +R  AE+  +E +++ +Q+   LK   E LQ+ +E A+ 
Sbjct: 2263 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2308

Query: 495  IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
               E+A+R    K++   QL  E +   R   A        R RQ     E  R  L  A
Sbjct: 2309 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2358

Query: 554  SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
             + RAQ   E  A         IG KL R+E  T+E+ + +++     + S H  E++RE
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418

Query: 605  ETN--TRSFDRMVREAQL 620
                  R  +++ +EA+L
Sbjct: 2419 AIAELEREKEKLQQEAKL 2436



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)

Query: 325  LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
            +S + +  +  ER+  Q RAE       ER+R      LA  +  L    Q A AH Q  
Sbjct: 1305 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1349

Query: 385  LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
                 AK + ERE +E Q+ +++   RR  AA   +++ R  +EE +  R+      +++
Sbjct: 1350 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1404

Query: 443  ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
             R+ E AER  L          L+ E  ER               A E   +K Q ++  
Sbjct: 1405 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1464

Query: 479  KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
            ++    +Q+  +R  Q   E A R      AAR KQR    L+  + +   AER   +A 
Sbjct: 1465 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1524

Query: 533  LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
            ++ R RQ +   E  + S EA L   + ++             EH+A+ +  E    R++
Sbjct: 1525 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1583

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
            Q     R+  E+ R   R      E +R         +    AQ  A   ++
Sbjct: 1584 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1635



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)

Query: 330  QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
            Q A   ER  R+   R ++ L    E  R RK A   + R +   EE   L +RA     
Sbjct: 1942 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2001

Query: 383  WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
             +LQ     A++R + EE+       +K++ L+Q  +   + +++ RG     E EAARR
Sbjct: 2002 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2056

Query: 434  RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
                 E +EE R + AER+    R + E A R         +Q+ +++ +   + +  AE
Sbjct: 2057 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2104

Query: 494  QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
            ++R+E  Q AAR  Q ++  L+  +++ + AE  +H+   +   RQ+ Q  + L      
Sbjct: 2105 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2157

Query: 554  SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
            +L    E  +H    +K    E+L R +  A E+AR  ++     F VR ++ E
Sbjct: 2158 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)

Query: 353  ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
            ++ +++A     R QE+   + Q+ A   Q   + + A+++R+ E     ER K R  E 
Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2360

Query: 408  GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
             R    A+ + +R R+  EE      R                 QRQ      ER  E  
Sbjct: 2361 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2420

Query: 446  RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
             EL   +  L++E      + + ++ +QQEQ L Q  + LQ+    E+   ++RER    
Sbjct: 2421 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2479

Query: 504  ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
             +AK  Q  Q      E+++A++ R E   Q + +Q  QER+ L +S+E +  R  E  E
Sbjct: 2480 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2532

Query: 564  HLAIGRKLERSEQLTRERRSALE 586
               + RK E  +QL ++RR   E
Sbjct: 2533 --GVRRKQEELQQLEQQRRQQEE 2553



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)

Query: 336  ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
            E++ +Q+  E +G +   E +R+    M A  +   L + +  RA A  + + QR   KQ
Sbjct: 2319 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2377

Query: 393  RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
              E  E+  +  L    +    Q  E + ++   + E  R    + ER +E+ ++ A+  
Sbjct: 2378 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2437

Query: 453  GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
             L + E  +   +E  L++ Q        ++ +L QRE  +++ + + EQ+ ++   +AQ
Sbjct: 2438 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2496

Query: 502  RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
            +    +QRQ+ Q+++E++ L      A R +HEA    R +Q+  Q+ E  R   E  L 
Sbjct: 2497 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2555

Query: 557  RAQENYEHLAIGRKLERSEQLTRERRSAL 585
             A+EN       R  E+ + L  + R+AL
Sbjct: 2556 -AEENQ------RLREQLQLLEEQHRAAL 2577



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)

Query: 367  QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
            Q E  + +++A     ++ +   A+Q RE ++R+ Q+ +EQ R+   A +EE R RR  E
Sbjct: 2472 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2529

Query: 427  EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
              E  RR+Q + ++ E++RR+    LAE    LR      E   RAA     E    ++ 
Sbjct: 2530 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2589

Query: 474  QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
              + L    + L      AE         R+  AQR   A      +LQR  +      E
Sbjct: 2590 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2649

Query: 521  LSRAERARHEALLQGRT 537
            L+R E  RH   LQGR+
Sbjct: 2650 LARREDVRH--YLQGRS 2664



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)

Query: 24   EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
            EE +  AE   +     V       Q A+E A + A A A+A   RK E    AA   + 
Sbjct: 2062 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2120

Query: 84   EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
            EQ+ L      + +  +            A+  + + T    LE          E L R 
Sbjct: 2121 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2180

Query: 132  LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
             A+    A  RS            M   + L    EAE RA + + +   +R ++EE  +
Sbjct: 2181 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2240

Query: 180  LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
            +      AA  + AA  A+     +    +     A         A + A +        
Sbjct: 2241 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2300

Query: 233  RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
            + Q   A  +  R     + ++++    L+ E+     +   E  R+L            
Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2356

Query: 285  -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
                 RA AR    A          G     T +    +   +  L    Q + H    +
Sbjct: 2357 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2416

Query: 340  RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
            R+  AE  L    E+ ++ A L+  + +E      E LL E +A    Q  L    +  +
Sbjct: 2417 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2472

Query: 394  REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
            RER   +++  LEQ  +   A+ ++ R  + R++++  + RQR     EE RR       
Sbjct: 2473 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2525

Query: 454  LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
                            R+ + E+ +++++E LQ+     EQ RR++ +  A   QR   Q
Sbjct: 2526 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2565

Query: 514  LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
            LQ    E  RA  A  E +   +    +    G R +L+     A+  +    + RK+  
Sbjct: 2566 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2622

Query: 574  SEQLTRERRSALESARSTARASFHVREKVREE 605
            +++L      + E  +  A+    V E  R E
Sbjct: 2623 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2654



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)

Query: 331  TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
            +A ++E++       RG +G  E        +L  H+E+L   E +A      EL+   A
Sbjct: 1049 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1098

Query: 391  KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
              ++ R + E Q+      R      +E RG +   ER     +QR  ER  E  R    
Sbjct: 1099 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1148

Query: 451  RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
               LL R +A  A  + R R+L+Q                   Q+ ++R+E +Q     +
Sbjct: 1149 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1208

Query: 488  GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
             +   EQ+R+E+A               QR A+    A +  E QL   K +L       
Sbjct: 1209 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1268

Query: 529  HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
             +  +Q  +    QE   LR+                +   R  E  E LA  ++ E  E
Sbjct: 1269 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1328

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
            +L  E  +ALE  R  A A  H + K + E   +   + ++E
Sbjct: 1329 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1367


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)

Query: 155  EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
            +AER AK  Q R + E + REE        KR +   L     ++ A   A A  A +  
Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1579

Query: 207  SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
                       A R+  +        R Q      + G     L +L  R E A + +  
Sbjct: 1580 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628

Query: 267  ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
            A   +         ES R+ +     ++R    A +A     A      L L      R 
Sbjct: 1629 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1688

Query: 320  FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
                ++  + Q    +E   R   AE   +     + K A L  +  +E + + + R  A
Sbjct: 1689 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1747

Query: 380  HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
              + + Q+  A++ RE  ERE +R   +   A   +++     + +   +A   +Q++  
Sbjct: 1748 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1806

Query: 440  RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
              E RRR  AE Q + +RE AE+   + R        ++L  EQ L     + E+G Q+ 
Sbjct: 1807 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1866

Query: 489  RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
            +   E++ R + + AA  ++RQE + +  K       RA  E LL  + R + + R   E
Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1920

Query: 546  GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
              +  LEA  GR +E  E  A  R L  +E+  R+R+ A E +AR  A A   + EK+
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)

Query: 53   EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
            E  A   S + + A  +K E    A   G+ E+  +   +L   +  +    AEG+    
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1845

Query: 109  TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
             +       L A      +  +LL   LA L REA   + +           E  A+L +
Sbjct: 1846 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1896

Query: 165  CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
             RAE E ++  + R         + +  +     A +         A+   + A  A R+
Sbjct: 1897 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1953

Query: 225  ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
               +   A  Q   A      K  ++   +R +  A   E          E LR L    
Sbjct: 1954 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 2009

Query: 285  RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
             A  R      +A    +   R + L     +      G +  + +  + VE  +  ++A
Sbjct: 2010 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 2069

Query: 345  --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
              E+   G  E + ++  +    + E+ L  +++A   A  Q +L     ++RRE EE  
Sbjct: 2070 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 2127

Query: 399  -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
                       R+++ ALE+  R   A+VEE R  R R E+E+AR+ Q   E +++R   
Sbjct: 2128 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2183

Query: 448  LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
                  L   E+A   A + + ++LQ  Q L+Q +  L + R  AE  RR  A+ A  A+
Sbjct: 2184 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2234

Query: 508  QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
             + E +  + +R++  AER +  A  Q + R Q Q   E LR   E    R +   E  A
Sbjct: 2235 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2293

Query: 567  IGRKLERSEQLTRERRSALESARSTAR 593
            + +K     ++ + ++ A ++ R  A+
Sbjct: 2294 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2320



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)

Query: 155  EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
            E ER +AK+++ R  RER  +E  R+L      A     A   A A +          +L
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2206

Query: 214  PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
                +          AAR+A+     AR Q     +++ R+    + L +  E    + +
Sbjct: 2207 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2266

Query: 266  GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
             A +++       E     RA A  +      ++               R  A     +T
Sbjct: 2267 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2326

Query: 317  GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
                 L +  H       ++  +++++AE       +R +    L   R Q EEL  L+ 
Sbjct: 2327 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2382

Query: 376  RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
            R  A  +  + R     QR  +EE EK +           QV E   R     +EAAR R
Sbjct: 2383 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2431

Query: 435  QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
            Q            LAE     +R  AE+  +E +++ +Q+   LK   E LQ+ +E A+ 
Sbjct: 2432 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2477

Query: 495  IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
               E+A+R    K++   QL  E +   R   A        R RQ     E  R  L  A
Sbjct: 2478 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2527

Query: 554  SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
             + RAQ   E  A         IG KL R+E  T+E+ + +++     + S H  E++RE
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587

Query: 605  ETN--TRSFDRMVREAQL 620
                  R  +++ +EA+L
Sbjct: 2588 AIAELEREKEKLQQEAKL 2605



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)

Query: 325  LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
            +S + +  +  ER+  Q RAE       ER+R      LA  +  L    Q A AH Q  
Sbjct: 1474 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1518

Query: 385  LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
                 AK + ERE +E Q+ +++   RR  AA   +++ R  +EE +  R+      +++
Sbjct: 1519 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1573

Query: 443  ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
             R+ E AER  L          L+ E  ER               A E   +K Q ++  
Sbjct: 1574 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1633

Query: 479  KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
            ++    +Q+  +R  Q   E A R      AAR KQR    L+  + +   AER   +A 
Sbjct: 1634 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1693

Query: 533  LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
            ++ R RQ +   E  + S EA L   + ++             EH+A+ +  E    R++
Sbjct: 1694 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1752

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
            Q     R+  E+ R   R      E +R         +    AQ  A   ++
Sbjct: 1753 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1804



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)

Query: 330  QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
            Q A   ER  R+   R ++ L    E  R RK A   + R +   EE   L +RA     
Sbjct: 2111 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2170

Query: 383  WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
             +LQ     A++R + EE+       +K++ L+Q  +   + +++ RG     E EAARR
Sbjct: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2225

Query: 434  RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
                 E +EE R + AER+    R + E A R         +Q+ +++ +   + +  AE
Sbjct: 2226 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2273

Query: 494  QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
            ++R+E  Q AAR  Q ++  L+  +++ + AE  +H+   +   RQ+ Q  + L      
Sbjct: 2274 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2326

Query: 554  SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
            +L    E  +H    +K    E+L R +  A E+AR  ++     F VR ++ E
Sbjct: 2327 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)

Query: 353  ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
            ++ +++A     R QE+   + Q+ A   Q   + + A+++R+ E     ER K R  E 
Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2529

Query: 408  GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
             R    A+ + +R R+  EE      R                 QRQ      ER  E  
Sbjct: 2530 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2589

Query: 446  RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
             EL   +  L++E      + + ++ +QQEQ L Q  + LQ+    E+   ++RER    
Sbjct: 2590 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2648

Query: 504  ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
             +AK  Q  Q      E+++A++ R E   Q + +Q  QER+ L +S+E +  R  E  E
Sbjct: 2649 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2701

Query: 564  HLAIGRKLERSEQLTRERRSALE 586
               + RK E  +QL ++RR   E
Sbjct: 2702 --GVRRKQEELQQLEQQRRQQEE 2722



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)

Query: 336  ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
            E++ +Q+  E +G +   E +R+    M A  +   L + +  RA A  + + QR   KQ
Sbjct: 2488 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2546

Query: 393  RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
              E  E+  +  L    +    Q  E + ++   + E  R    + ER +E+ ++ A+  
Sbjct: 2547 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606

Query: 453  GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
             L + E  +   +E  L++ Q        ++ +L QRE  +++ + + EQ+ ++   +AQ
Sbjct: 2607 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2665

Query: 502  RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
            +    +QRQ+ Q+++E++ L      A R +HEA    R +Q+  Q+ E  R   E  L 
Sbjct: 2666 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2724

Query: 557  RAQENYEHLAIGRKLERSEQLTRERRSAL 585
             A+EN       R  E+ + L  + R+AL
Sbjct: 2725 -AEENQ------RLREQLQLLEEQHRAAL 2746



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)

Query: 367  QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
            Q E  + +++A     ++ +   A+Q RE ++R+ Q+ +EQ R+   A +EE R RR  E
Sbjct: 2641 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2698

Query: 427  EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
              E  RR+Q + ++ E++RR+    LAE    LR      E   RAA     E    ++ 
Sbjct: 2699 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2758

Query: 474  QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
              + L    + L      AE         R+  AQR   A      +LQR  +      E
Sbjct: 2759 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2818

Query: 521  LSRAERARHEALLQGRT 537
            L+R E  RH   LQGR+
Sbjct: 2819 LARREDVRH--YLQGRS 2833



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)

Query: 24   EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
            EE +  AE   +     V       Q A+E A + A A A+A   RK E    AA   + 
Sbjct: 2231 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2289

Query: 84   EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
            EQ+ L      + +  +            A+  + + T    LE          E L R 
Sbjct: 2290 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2349

Query: 132  LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
             A+    A  RS            M   + L    EAE RA + + +   +R ++EE  +
Sbjct: 2350 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2409

Query: 180  LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
            +      AA  + AA  A+     +    +     A         A + A +        
Sbjct: 2410 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2469

Query: 233  RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
            + Q   A  +  R     + ++++    L+ E+     +   E  R+L            
Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2525

Query: 285  -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
                 RA AR    A          G     T +    +   +  L    Q + H    +
Sbjct: 2526 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2585

Query: 340  RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
            R+  AE  L    E+ ++ A L+  + +E      E LL E +A    Q  L    +  +
Sbjct: 2586 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2641

Query: 394  REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
            RER   +++  LEQ  +   A+ ++ R  + R++++  + RQR     EE RR       
Sbjct: 2642 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2694

Query: 454  LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
                            R+ + E+ +++++E LQ+     EQ RR++ +  A   QR   Q
Sbjct: 2695 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2734

Query: 514  LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
            LQ    E  RA  A  E +   +    +    G R +L+     A+  +    + RK+  
Sbjct: 2735 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2791

Query: 574  SEQLTRERRSALESARSTARASFHVREKVREE 605
            +++L      + E  +  A+    V E  R E
Sbjct: 2792 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2823



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)

Query: 331  TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
            +A ++E++       RG +G  E        +L  H+E+L   E +A      EL+   A
Sbjct: 1218 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1267

Query: 391  KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
              ++ R + E Q+      R      +E RG +   ER     +QR  ER  E  R    
Sbjct: 1268 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1317

Query: 451  RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
               LL R +A  A  + R R+L+Q                   Q+ ++R+E +Q     +
Sbjct: 1318 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1377

Query: 488  GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
             +   EQ+R+E+A               QR A+    A +  E QL   K +L       
Sbjct: 1378 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1437

Query: 529  HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
             +  +Q  +    QE   LR+                +   R  E  E LA  ++ E  E
Sbjct: 1438 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1497

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
            +L  E  +ALE  R  A A  H + K + E   +   + ++E
Sbjct: 1498 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1536


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)

Query: 155  EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
            +AER AK  Q R + E + REE        KR +   L     ++ A   A A  A +  
Sbjct: 1363 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1420

Query: 207  SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
                       A R+  +        R Q      + G     L +L  R E A + +  
Sbjct: 1421 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469

Query: 267  ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
            A   +         ES R+ +     ++R    A +A     A      L L      R 
Sbjct: 1470 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1529

Query: 320  FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
                ++  + Q    +E   R   AE   +     + K A L  +  +E + + + R  A
Sbjct: 1530 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1588

Query: 380  HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
              + + Q+  A++ RE  ERE +R   +   A   +++     + +   +A   +Q++  
Sbjct: 1589 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1647

Query: 440  RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
              E RRR  AE Q + +RE AE+   + R        ++L  EQ L     + E+G Q+ 
Sbjct: 1648 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1707

Query: 489  RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
            +   E++ R + + AA  ++RQE + +  K       RA  E LL  + R + + R   E
Sbjct: 1708 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1761

Query: 546  GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
              +  LEA  GR +E  E  A  R L  +E+  R+R+ A E +AR  A A   + EK+
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1817



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)

Query: 53   EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
            E  A   S + + A  +K E    A   G+ E+  +   +L   +  +    AEG+    
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1686

Query: 109  TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
             +       L A      +  +LL   LA L REA   + +           E  A+L +
Sbjct: 1687 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1737

Query: 165  CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
             RAE E ++  + R         + +  +     A +         A+   + A  A R+
Sbjct: 1738 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1794

Query: 225  ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
               +   A  Q   A      K  ++   +R +  A   E          E LR L    
Sbjct: 1795 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 1850

Query: 285  RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
             A  R      +A    +   R + L     +      G +  + +  + VE  +  ++A
Sbjct: 1851 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1910

Query: 345  --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
              E+   G  E + ++  +    + E+ L  +++A   A  Q +L     ++RRE EE  
Sbjct: 1911 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1968

Query: 399  -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
                       R+++ ALE+  R   A+VEE R  R R E+E+AR+ Q   E +++R   
Sbjct: 1969 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2024

Query: 448  LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
                  L   E+A   A + + ++LQ  Q L+Q +  L + R  AE  RR  A+ A  A+
Sbjct: 2025 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2075

Query: 508  QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
             + E +  + +R++  AER +  A  Q + R Q Q   E LR   E    R +   E  A
Sbjct: 2076 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2134

Query: 567  IGRKLERSEQLTRERRSALESARSTAR 593
            + +K     ++ + ++ A ++ R  A+
Sbjct: 2135 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2161



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)

Query: 155  EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
            E ER +AK+++ R  RER  +E  R+L      A     A   A A +          +L
Sbjct: 1988 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2047

Query: 214  PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
                +          AAR+A+     AR Q     +++ R+    + L +  E    + +
Sbjct: 2048 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2107

Query: 266  GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
             A +++       E     RA A  +      ++               R  A     +T
Sbjct: 2108 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2167

Query: 317  GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
                 L +  H       ++  +++++AE       +R +    L   R Q EEL  L+ 
Sbjct: 2168 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2223

Query: 376  RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
            R  A  +  + R     QR  +EE EK +           QV E   R     +EAAR R
Sbjct: 2224 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2272

Query: 435  QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
            Q            LAE     +R  AE+  +E +++ +Q+   LK   E LQ+ +E A+ 
Sbjct: 2273 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2318

Query: 495  IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
               E+A+R    K++   QL  E +   R   A        R RQ     E  R  L  A
Sbjct: 2319 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2368

Query: 554  SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
             + RAQ   E  A         IG KL R+E  T+E+ + +++     + S H  E++RE
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428

Query: 605  ETN--TRSFDRMVREAQL 620
                  R  +++ +EA+L
Sbjct: 2429 AIAELEREKEKLQQEAKL 2446



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)

Query: 325  LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
            +S + +  +  ER+  Q RAE       ER+R      LA  +  L    Q A AH Q  
Sbjct: 1315 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1359

Query: 385  LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
                 AK + ERE +E Q+ +++   RR  AA   +++ R  +EE +  R+      +++
Sbjct: 1360 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1414

Query: 443  ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
             R+ E AER  L          L+ E  ER               A E   +K Q ++  
Sbjct: 1415 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1474

Query: 479  KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
            ++    +Q+  +R  Q   E A R      AAR KQR    L+  + +   AER   +A 
Sbjct: 1475 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1534

Query: 533  LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
            ++ R RQ +   E  + S EA L   + ++             EH+A+ +  E    R++
Sbjct: 1535 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1593

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
            Q     R+  E+ R   R      E +R         +    AQ  A   ++
Sbjct: 1594 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1645



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)

Query: 330  QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
            Q A   ER  R+   R ++ L    E  R RK A   + R +   EE   L +RA     
Sbjct: 1952 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2011

Query: 383  WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
             +LQ     A++R + EE+       +K++ L+Q  +   + +++ RG     E EAARR
Sbjct: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2066

Query: 434  RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
                 E +EE R + AER+    R + E A R         +Q+ +++ +   + +  AE
Sbjct: 2067 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2114

Query: 494  QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
            ++R+E  Q AAR  Q ++  L+  +++ + AE  +H+   +   RQ+ Q  + L      
Sbjct: 2115 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2167

Query: 554  SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
            +L    E  +H    +K    E+L R +  A E+AR  ++     F VR ++ E
Sbjct: 2168 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)

Query: 353  ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
            ++ +++A     R QE+   + Q+ A   Q   + + A+++R+ E     ER K R  E 
Sbjct: 2311 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2370

Query: 408  GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
             R    A+ + +R R+  EE      R                 QRQ      ER  E  
Sbjct: 2371 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2430

Query: 446  RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
             EL   +  L++E      + + ++ +QQEQ L Q  + LQ+    E+   ++RER    
Sbjct: 2431 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2489

Query: 504  ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
             +AK  Q  Q      E+++A++ R E   Q + +Q  QER+ L +S+E +  R  E  E
Sbjct: 2490 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2542

Query: 564  HLAIGRKLERSEQLTRERRSALE 586
               + RK E  +QL ++RR   E
Sbjct: 2543 --GVRRKQEELQQLEQQRRQQEE 2563



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)

Query: 336  ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
            E++ +Q+  E +G +   E +R+    M A  +   L + +  RA A  + + QR   KQ
Sbjct: 2329 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2387

Query: 393  RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
              E  E+  +  L    +    Q  E + ++   + E  R    + ER +E+ ++ A+  
Sbjct: 2388 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447

Query: 453  GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
             L + E  +   +E  L++ Q        ++ +L QRE  +++ + + EQ+ ++   +AQ
Sbjct: 2448 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2506

Query: 502  RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
            +    +QRQ+ Q+++E++ L      A R +HEA    R +Q+  Q+ E  R   E  L 
Sbjct: 2507 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2565

Query: 557  RAQENYEHLAIGRKLERSEQLTRERRSAL 585
             A+EN       R  E+ + L  + R+AL
Sbjct: 2566 -AEENQ------RLREQLQLLEEQHRAAL 2587



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)

Query: 367  QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
            Q E  + +++A     ++ +   A+Q RE ++R+ Q+ +EQ R+   A +EE R RR  E
Sbjct: 2482 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2539

Query: 427  EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
              E  RR+Q + ++ E++RR+    LAE    LR      E   RAA     E    ++ 
Sbjct: 2540 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2599

Query: 474  QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
              + L    + L      AE         R+  AQR   A      +LQR  +      E
Sbjct: 2600 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2659

Query: 521  LSRAERARHEALLQGRT 537
            L+R E  RH   LQGR+
Sbjct: 2660 LARREDVRH--YLQGRS 2674



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)

Query: 24   EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
            EE +  AE   +     V       Q A+E A + A A A+A   RK E    AA   + 
Sbjct: 2072 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2130

Query: 84   EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
            EQ+ L      + +  +            A+  + + T    LE          E L R 
Sbjct: 2131 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2190

Query: 132  LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
             A+    A  RS            M   + L    EAE RA + + +   +R ++EE  +
Sbjct: 2191 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2250

Query: 180  LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
            +      AA  + AA  A+     +    +     A         A + A +        
Sbjct: 2251 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2310

Query: 233  RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
            + Q   A  +  R     + ++++    L+ E+     +   E  R+L            
Sbjct: 2311 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2366

Query: 285  -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
                 RA AR    A          G     T +    +   +  L    Q + H    +
Sbjct: 2367 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2426

Query: 340  RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
            R+  AE  L    E+ ++ A L+  + +E      E LL E +A    Q  L    +  +
Sbjct: 2427 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2482

Query: 394  REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
            RER   +++  LEQ  +   A+ ++ R  + R++++  + RQR     EE RR       
Sbjct: 2483 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2535

Query: 454  LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
                            R+ + E+ +++++E LQ+     EQ RR++ +  A   QR   Q
Sbjct: 2536 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2575

Query: 514  LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
            LQ    E  RA  A  E +   +    +    G R +L+     A+  +    + RK+  
Sbjct: 2576 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2632

Query: 574  SEQLTRERRSALESARSTARASFHVREKVREE 605
            +++L      + E  +  A+    V E  R E
Sbjct: 2633 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2664



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)

Query: 331  TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
            +A ++E++       RG +G  E        +L  H+E+L   E +A      EL+   A
Sbjct: 1059 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1108

Query: 391  KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
              ++ R + E Q+      R      +E RG +   ER     +QR  ER  E  R    
Sbjct: 1109 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1158

Query: 451  RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
               LL R +A  A  + R R+L+Q                   Q+ ++R+E +Q     +
Sbjct: 1159 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1218

Query: 488  GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
             +   EQ+R+E+A               QR A+    A +  E QL   K +L       
Sbjct: 1219 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1278

Query: 529  HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
             +  +Q  +    QE   LR+                +   R  E  E LA  ++ E  E
Sbjct: 1279 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1338

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
            +L  E  +ALE  R  A A  H + K + E   +   + ++E
Sbjct: 1339 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1377


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)

Query: 155  EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
            +AER AK  Q R + E + REE        KR +   L     ++ A   A A  A +  
Sbjct: 1371 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1428

Query: 207  SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
                       A R+  +        R Q      + G     L +L  R E A + +  
Sbjct: 1429 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1477

Query: 267  ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
            A   +         ES R+ +     ++R    A +A     A      L L      R 
Sbjct: 1478 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1537

Query: 320  FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
                ++  + Q    +E   R   AE   +     + K A L  +  +E + + + R  A
Sbjct: 1538 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1596

Query: 380  HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
              + + Q+  A++ RE  ERE +R   +   A   +++     + +   +A   +Q++  
Sbjct: 1597 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1655

Query: 440  RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
              E RRR  AE Q + +RE AE+   + R        ++L  EQ L     + E+G Q+ 
Sbjct: 1656 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1715

Query: 489  RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
            +   E++ R + + AA  ++RQE + +  K       RA  E LL  + R + + R   E
Sbjct: 1716 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1769

Query: 546  GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
              +  LEA  GR +E  E  A  R L  +E+  R+R+ A E +AR  A A   + EK+
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1825



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)

Query: 53   EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
            E  A   S + + A  +K E    A   G+ E+  +   +L   +  +    AEG+    
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1694

Query: 109  TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
             +       L A      +  +LL   LA L REA   + +           E  A+L +
Sbjct: 1695 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1745

Query: 165  CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
             RAE E ++  + R         + +  +     A +         A+   + A  A R+
Sbjct: 1746 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1802

Query: 225  ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
               +   A  Q   A      K  ++   +R +  A   E          E LR L    
Sbjct: 1803 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 1858

Query: 285  RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
             A  R      +A    +   R + L     +      G +  + +  + VE  +  ++A
Sbjct: 1859 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1918

Query: 345  --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
              E+   G  E + ++  +    + E+ L  +++A   A  Q +L     ++RRE EE  
Sbjct: 1919 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1976

Query: 399  -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
                       R+++ ALE+  R   A+VEE R  R R E+E+AR+ Q   E +++R   
Sbjct: 1977 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2032

Query: 448  LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
                  L   E+A   A + + ++LQ  Q L+Q +  L + R  AE  RR  A+ A  A+
Sbjct: 2033 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2083

Query: 508  QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
             + E +  + +R++  AER +  A  Q + R Q Q   E LR   E    R +   E  A
Sbjct: 2084 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2142

Query: 567  IGRKLERSEQLTRERRSALESARSTAR 593
            + +K     ++ + ++ A ++ R  A+
Sbjct: 2143 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2169



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)

Query: 155  EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
            E ER +AK+++ R  RER  +E  R+L      A     A   A A +          +L
Sbjct: 1996 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2055

Query: 214  PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
                +          AAR+A+     AR Q     +++ R+    + L +  E    + +
Sbjct: 2056 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2115

Query: 266  GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
             A +++       E     RA A  +      ++               R  A     +T
Sbjct: 2116 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2175

Query: 317  GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
                 L +  H       ++  +++++AE       +R +    L   R Q EEL  L+ 
Sbjct: 2176 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2231

Query: 376  RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
            R  A  +  + R     QR  +EE EK +           QV E   R     +EAAR R
Sbjct: 2232 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2280

Query: 435  QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
            Q            LAE     +R  AE+  +E +++ +Q+   LK   E LQ+ +E A+ 
Sbjct: 2281 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2326

Query: 495  IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
               E+A+R    K++   QL  E +   R   A        R RQ     E  R  L  A
Sbjct: 2327 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2376

Query: 554  SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
             + RAQ   E  A         IG KL R+E  T+E+ + +++     + S H  E++RE
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436

Query: 605  ETN--TRSFDRMVREAQL 620
                  R  +++ +EA+L
Sbjct: 2437 AIAELEREKEKLQQEAKL 2454



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)

Query: 325  LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
            +S + +  +  ER+  Q RAE       ER+R      LA  +  L    Q A AH Q  
Sbjct: 1323 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1367

Query: 385  LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
                 AK + ERE +E Q+ +++   RR  AA   +++ R  +EE +  R+      +++
Sbjct: 1368 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1422

Query: 443  ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
             R+ E AER  L          L+ E  ER               A E   +K Q ++  
Sbjct: 1423 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1482

Query: 479  KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
            ++    +Q+  +R  Q   E A R      AAR KQR    L+  + +   AER   +A 
Sbjct: 1483 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1542

Query: 533  LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
            ++ R RQ +   E  + S EA L   + ++             EH+A+ +  E    R++
Sbjct: 1543 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1601

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
            Q     R+  E+ R   R      E +R         +    AQ  A   ++
Sbjct: 1602 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1653



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)

Query: 330  QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
            Q A   ER  R+   R ++ L    E  R RK A   + R +   EE   L +RA     
Sbjct: 1960 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2019

Query: 383  WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
             +LQ     A++R + EE+       +K++ L+Q  +   + +++ RG     E EAARR
Sbjct: 2020 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2074

Query: 434  RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
                 E +EE R + AER+    R + E A R         +Q+ +++ +   + +  AE
Sbjct: 2075 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2122

Query: 494  QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
            ++R+E  Q AAR  Q ++  L+  +++ + AE  +H+   +   RQ+ Q  + L      
Sbjct: 2123 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2175

Query: 554  SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
            +L    E  +H    +K    E+L R +  A E+AR  ++     F VR ++ E
Sbjct: 2176 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2225



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)

Query: 353  ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
            ++ +++A     R QE+   + Q+ A   Q   + + A+++R+ E     ER K R  E 
Sbjct: 2319 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2378

Query: 408  GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
             R    A+ + +R R+  EE      R                 QRQ      ER  E  
Sbjct: 2379 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2438

Query: 446  RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
             EL   +  L++E      + + ++ +QQEQ L Q  + LQ+    E+   ++RER    
Sbjct: 2439 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2497

Query: 504  ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
             +AK  Q  Q      E+++A++ R E   Q + +Q  QER+ L +S+E +  R  E  E
Sbjct: 2498 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2550

Query: 564  HLAIGRKLERSEQLTRERRSALE 586
               + RK E  +QL ++RR   E
Sbjct: 2551 --GVRRKQEELQQLEQQRRQQEE 2571



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)

Query: 336  ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
            E++ +Q+  E +G +   E +R+    M A  +   L + +  RA A  + + QR   KQ
Sbjct: 2337 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2395

Query: 393  RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
              E  E+  +  L    +    Q  E + ++   + E  R    + ER +E+ ++ A+  
Sbjct: 2396 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2455

Query: 453  GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
             L + E  +   +E  L++ Q        ++ +L QRE  +++ + + EQ+ ++   +AQ
Sbjct: 2456 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2514

Query: 502  RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
            +    +QRQ+ Q+++E++ L      A R +HEA    R +Q+  Q+ E  R   E  L 
Sbjct: 2515 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2573

Query: 557  RAQENYEHLAIGRKLERSEQLTRERRSAL 585
             A+EN       R  E+ + L  + R+AL
Sbjct: 2574 -AEENQ------RLREQLQLLEEQHRAAL 2595



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)

Query: 367  QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
            Q E  + +++A     ++ +   A+Q RE ++R+ Q+ +EQ R+   A +EE R RR  E
Sbjct: 2490 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2547

Query: 427  EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
              E  RR+Q + ++ E++RR+    LAE    LR      E   RAA     E    ++ 
Sbjct: 2548 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2607

Query: 474  QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
              + L    + L      AE         R+  AQR   A      +LQR  +      E
Sbjct: 2608 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2667

Query: 521  LSRAERARHEALLQGRT 537
            L+R E  RH   LQGR+
Sbjct: 2668 LARREDVRH--YLQGRS 2682



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)

Query: 24   EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
            EE +  AE   +     V       Q A+E A + A A A+A   RK E    AA   + 
Sbjct: 2080 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2138

Query: 84   EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
            EQ+ L      + +  +            A+  + + T    LE          E L R 
Sbjct: 2139 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2198

Query: 132  LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
             A+    A  RS            M   + L    EAE RA + + +   +R ++EE  +
Sbjct: 2199 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2258

Query: 180  LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
            +      AA  + AA  A+     +    +     A         A + A +        
Sbjct: 2259 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2318

Query: 233  RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
            + Q   A  +  R     + ++++    L+ E+     +   E  R+L            
Sbjct: 2319 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2374

Query: 285  -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
                 RA AR    A          G     T +    +   +  L    Q + H    +
Sbjct: 2375 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2434

Query: 340  RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
            R+  AE  L    E+ ++ A L+  + +E      E LL E +A    Q  L    +  +
Sbjct: 2435 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2490

Query: 394  REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
            RER   +++  LEQ  +   A+ ++ R  + R++++  + RQR     EE RR       
Sbjct: 2491 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2543

Query: 454  LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
                            R+ + E+ +++++E LQ+     EQ RR++ +  A   QR   Q
Sbjct: 2544 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2583

Query: 514  LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
            LQ    E  RA  A  E +   +    +    G R +L+     A+  +    + RK+  
Sbjct: 2584 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2640

Query: 574  SEQLTRERRSALESARSTARASFHVREKVREE 605
            +++L      + E  +  A+    V E  R E
Sbjct: 2641 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2672



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)

Query: 331  TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
            +A ++E++       RG +G  E        +L  H+E+L   E +A      EL+   A
Sbjct: 1067 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1116

Query: 391  KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
              ++ R + E Q+      R      +E RG +   ER     +QR  ER  E  R    
Sbjct: 1117 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1166

Query: 451  RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
               LL R +A  A  + R R+L+Q                   Q+ ++R+E +Q     +
Sbjct: 1167 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1226

Query: 488  GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
             +   EQ+R+E+A               QR A+    A +  E QL   K +L       
Sbjct: 1227 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1286

Query: 529  HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
             +  +Q  +    QE   LR+                +   R  E  E LA  ++ E  E
Sbjct: 1287 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1346

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
            +L  E  +ALE  R  A A  H + K + E   +   + ++E
Sbjct: 1347 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1385


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 53/478 (11%)

Query: 155  EAERRAKLQQCRAERERIMREE--------KRRLFTPLSPAAAAAAAAAAASAPSAGSSS 206
            +AER AK  Q R + E + REE        KR +   L     ++ A   A A  A +  
Sbjct: 1412 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA-- 1469

Query: 207  SCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESG 266
                       A R+  +        R Q      + G     L +L  R E A + +  
Sbjct: 1470 -----------AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1518

Query: 267  ASSSS------YSGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTL-VPITGRS 319
            A   +         ES R+ +     ++R    A +A     A      L L      R 
Sbjct: 1519 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1578

Query: 320  FSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAA 379
                ++  + Q    +E   R   AE   +     + K A L  +  +E + + + R  A
Sbjct: 1579 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTAQLERSLQEEHVAVAQLREEA 1637

Query: 380  HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYE 439
              + + Q+  A++ RE  ERE +R   +   A   +++     + +   +A   +Q++  
Sbjct: 1638 ERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1696

Query: 440  RSEERRRELAERQGLLRRERAERAAREDR-------LRKLQQEQNL----KQREEGLQEG 488
              E RRR  AE Q + +RE AE+   + R        ++L  EQ L     + E+G Q+ 
Sbjct: 1697 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1756

Query: 489  RERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQER---E 545
            +   E++ R + + AA  ++RQE + +  K       RA  E LL  + R + + R   E
Sbjct: 1757 QLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEVLLASKARAEEESRSTSE 1810

Query: 546  GLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALE-SARSTARASFHVREKV 602
              +  LEA  GR +E  E  A  R L  +E+  R+R+ A E +AR  A A   + EK+
Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAEAERVLAEKL 1866



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 128/567 (22%), Positives = 224/567 (39%), Gaps = 58/567 (10%)

Query: 53   EPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDCPE----AEGSRYVL 108
            E  A   S + + A  +K E    A   G+ E+  +   +L   +  +    AEG+    
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1735

Query: 109  TSPRS----LEACARCAVKPVELLPRALADLVREAPGRSMRVATGLYEAYEAERRAKLQQ 164
             +       L A      +  +LL   LA L REA   + +           E  A+L +
Sbjct: 1736 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---------RQELEAELAK 1786

Query: 165  CRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARK 224
             RAE E ++  + R         + +  +     A +         A+   + A  A R+
Sbjct: 1787 VRAEMEVLLASKAR---AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1843

Query: 225  ASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP 284
               +   A  Q   A      K  ++   +R +  A   E          E LR L    
Sbjct: 1844 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA---EIALKEKEAENERLRRLA-ED 1899

Query: 285  RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRA 344
             A  R      +A    +   R + L     +      G +  + +  + VE  +  ++A
Sbjct: 1900 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1959

Query: 345  --ERGLRGVPERDRKIAALMLARHQEELLLLEQRAA--AHGQWELQRVHAKQRREREE-- 398
              E+   G  E + ++  +    + E+ L  +++A   A  Q +L     ++RRE EE  
Sbjct: 1960 SFEKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 2017

Query: 399  -----------REKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRE 447
                       R+++ ALE+  R   A+VEE R  R R E+E+AR+ Q   E +++R   
Sbjct: 2018 QKSLAAEEEAARQRKAALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKR--- 2073

Query: 448  LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
                  L   E+A   A + + ++LQ  Q L+Q +  L + R  AE  RR  A+ A  A+
Sbjct: 2074 ------LQAEEKAHAFAVQQKEQELQ--QTLQQEQSVLDQLRGEAEAARR-AAEEAEEAR 2124

Query: 508  QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ-EREGLRSSLEASLGRAQENYEHLA 566
             + E +  + +R++  AER +  A  Q + R Q Q   E LR   E    R +   E  A
Sbjct: 2125 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAA 2183

Query: 567  IGRKLERSEQLTRERRSALESARSTAR 593
            + +K     ++ + ++ A ++ R  A+
Sbjct: 2184 LRQKQAADAEMEKHKKFAEQTLRQKAQ 2210



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 119/498 (23%), Positives = 193/498 (38%), Gaps = 71/498 (14%)

Query: 155  EAER-RAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASL 213
            E ER +AK+++ R  RER  +E  R+L      A     A   A A +          +L
Sbjct: 2037 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2096

Query: 214  PASPA--------PRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSES 265
                +          AAR+A+     AR Q     +++ R+    + L +  E    + +
Sbjct: 2097 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2156

Query: 266  GASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNAPG---------RPSALTLVPIT 316
             A +++       E     RA A  +      ++               R  A     +T
Sbjct: 2157 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2216

Query: 317  GRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQ-EELLLLEQ 375
                 L +  H       ++  +++++AE       +R +    L   R Q EEL  L+ 
Sbjct: 2217 TLRLQLEETDHQKNL---LDEELQRLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKA 2272

Query: 376  RAAAHGQWELQRVHAK-QRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRR 434
            R  A  +  + R     QR  +EE EK +           QV E   R     +EAAR R
Sbjct: 2273 RIEAENRALILRDKDNTQRFLQEEAEKMK-----------QVAEEAARLSVAAQEAARLR 2321

Query: 435  QRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQ 494
            Q            LAE     +R  AE+  +E +++ +Q+   LK   E LQ+ +E A+ 
Sbjct: 2322 Q------------LAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQ- 2367

Query: 495  IRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE-A 553
               E+A+R    K++   QL  E +   R   A        R RQ     E  R  L  A
Sbjct: 2368 ---EQARRLQEDKEQMAQQLAEETQGFQRTLEAE-------RQRQLEMSAEAERLKLRVA 2417

Query: 554  SLGRAQENYEHLA---------IGRKLERSEQLTRERRSALESARSTARASFHVREKVRE 604
             + RAQ   E  A         IG KL R+E  T+E+ + +++     + S H  E++RE
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477

Query: 605  ETN--TRSFDRMVREAQL 620
                  R  +++ +EA+L
Sbjct: 2478 AIAELEREKEKLQQEAKL 2495



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 87/352 (24%), Positives = 141/352 (40%), Gaps = 70/352 (19%)

Query: 325  LSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWE 384
            +S + +  +  ER+  Q RAE       ER+R      LA  +  L    Q A AH Q  
Sbjct: 1364 ISETLRRMEEEERLAEQQRAE-------ERER------LAEVEAALEKQRQLAEAHAQ-- 1408

Query: 385  LQRVHAKQRREREEREKQRALEQG--RRAWAAQVEERRGRRGREEREAARRRQRQYERSE 442
                 AK + ERE +E Q+ +++   RR  AA   +++ R  +EE +  R+      +++
Sbjct: 1409 -----AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1463

Query: 443  ERRRELAERQGL----------LRRERAERA--------------AREDRLRKLQQEQNL 478
             R+ E AER  L          L+ E  ER               A E   +K Q ++  
Sbjct: 1464 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1523

Query: 479  KQREEGLQEGRERAEQIRRERAQR------AARAKQRQEGQLQREKRELSRAERARHEAL 532
            ++    +Q+  +R  Q   E A R      AAR KQR    L+  + +   AER   +A 
Sbjct: 1524 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1583

Query: 533  LQGRTRQQRQEREGLRSSLEASLGRAQENY-------------EHLAIGRKLE----RSE 575
            ++ R RQ +   E  + S EA L   + ++             EH+A+ +  E    R++
Sbjct: 1584 VE-RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1642

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHASLDRK 627
            Q     R+  E+ R   R      E +R         +    AQ  A   ++
Sbjct: 1643 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1694



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 79/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)

Query: 330  QTAQHVERIVRQV--RAERGLRGVPE--RDRKIAALMLARHQ---EELLLLEQRAAAHGQ 382
            Q A   ER  R+   R ++ L    E  R RK A   + R +   EE   L +RA     
Sbjct: 2001 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2060

Query: 383  WELQRVH--AKQRREREER-------EKQRALEQGRRAWAAQVEERRGRRGREEREAARR 433
             +LQ     A++R + EE+       +K++ L+Q  +   + +++ RG     E EAARR
Sbjct: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG-----EAEAARR 2115

Query: 434  RQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAE 493
                 E +EE R + AER+    R + E A R         +Q+ +++ +   + +  AE
Sbjct: 2116 AA---EEAEEARVQ-AEREAAQSRRQVEEAER--------LKQSAEEQAQARAQAQAAAE 2163

Query: 494  QIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEA 553
            ++R+E  Q AAR  Q ++  L+  +++ + AE  +H+   +   RQ+ Q  + L      
Sbjct: 2164 KLRKEAEQEAARRAQAEQAALR--QKQAADAEMEKHKKFAEQTLRQKAQVEQEL-----T 2216

Query: 554  SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS---FHVREKVRE 604
            +L    E  +H    +K    E+L R +  A E+AR  ++     F VR ++ E
Sbjct: 2217 TLRLQLEETDH----QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2266



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 71/263 (26%), Positives = 118/263 (44%), Gaps = 39/263 (14%)

Query: 353  ERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRRERE-----EREKQRALEQ 407
            ++ +++A     R QE+   + Q+ A   Q   + + A+++R+ E     ER K R  E 
Sbjct: 2360 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2419

Query: 408  GRRAWAAQVEERRGRRGREEREAARRR-----------------QRQY-----ERSEERR 445
             R    A+ + +R R+  EE      R                 QRQ      ER  E  
Sbjct: 2420 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2479

Query: 446  RELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEG--RERAEQIRRERAQRA 503
             EL   +  L++E      + + ++ +QQEQ L Q  + LQ+    E+   ++RER    
Sbjct: 2480 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQ-LLQETQALQQSFLSEKDSLLQRERFIEQ 2538

Query: 504  ARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563
             +AK  Q  Q      E+++A++ R E   Q + +Q  QER+ L +S+E +  R  E  E
Sbjct: 2539 EKAKLEQLFQ-----DEVAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEE 2591

Query: 564  HLAIGRKLERSEQLTRERRSALE 586
               + RK E  +QL ++RR   E
Sbjct: 2592 --GVRRKQEELQQLEQQRRQQEE 2612



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 67/269 (24%), Positives = 127/269 (47%), Gaps = 29/269 (10%)

Query: 336  ERIVRQVRAE-RGLRGVPERDRKIAALMLARHQEELLLLEQ--RAAAHGQWELQRVHAKQ 392
            E++ +Q+  E +G +   E +R+    M A  +   L + +  RA A  + + QR   KQ
Sbjct: 2378 EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQ 2436

Query: 393  RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
              E  E+  +  L    +    Q  E + ++   + E  R    + ER +E+ ++ A+  
Sbjct: 2437 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496

Query: 453  GLLRRERAERAAREDRLRKLQ--------QEQNLKQREEGLQEGRERAEQIRRE---RAQ 501
             L + E  +   +E  L++ Q        ++ +L QRE  +++ + + EQ+ ++   +AQ
Sbjct: 2497 QL-KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2555

Query: 502  RAARAKQRQEGQLQREKREL----SRAERARHEALLQGRTRQQR-QEREGLRSSLEASLG 556
            +    +QRQ+ Q+++E++ L      A R +HEA    R +Q+  Q+ E  R   E  L 
Sbjct: 2556 QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL- 2614

Query: 557  RAQENYEHLAIGRKLERSEQLTRERRSAL 585
             A+EN       R  E+ + L  + R+AL
Sbjct: 2615 -AEENQ------RLREQLQLLEEQHRAAL 2636



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 58/197 (29%), Positives = 89/197 (45%), Gaps = 30/197 (15%)

Query: 367  QEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE 426
            Q E  + +++A     ++ +   A+Q RE ++R+ Q+ +EQ R+   A +EE R RR  E
Sbjct: 2531 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEAR-RRQHE 2588

Query: 427  EREAARRRQRQYERSEERRRE----LAERQGLLRR-----ERAERAA----REDRLRKLQ 473
              E  RR+Q + ++ E++RR+    LAE    LR      E   RAA     E    ++ 
Sbjct: 2589 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2648

Query: 474  QEQNLKQREEGLQEGRERAEQ-------IRRERAQRAARAKQRQEGQLQREKR------E 520
              + L    + L      AE         R+  AQR   A      +LQR  +      E
Sbjct: 2649 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2708

Query: 521  LSRAERARHEALLQGRT 537
            L+R E  RH   LQGR+
Sbjct: 2709 LARREDVRH--YLQGRS 2723



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 132/632 (20%), Positives = 227/632 (35%), Gaps = 89/632 (14%)

Query: 24   EEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRR 83
            EE +  AE   +     V       Q A+E A + A A A+A   RK E    AA   + 
Sbjct: 2121 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQA 2179

Query: 84   EQSPLLHLDLFNFDCPE------------AEGSRYVLTSPRSLEACARCAVKPVELLPRA 131
            EQ+ L      + +  +            A+  + + T    LE          E L R 
Sbjct: 2180 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2239

Query: 132  LADLVREAPGRS------------MRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR 179
             A+    A  RS            M   + L    EAE RA + + +   +R ++EE  +
Sbjct: 2240 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2299

Query: 180  LFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASP-------APRAARKASPSPSSA 232
            +      AA  + AA  A+     +    +     A         A + A +        
Sbjct: 2300 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2359

Query: 233  RTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPP-------- 284
            + Q   A  +  R     + ++++    L+ E+     +   E  R+L            
Sbjct: 2360 QQQKELAQEQARRLQEDKEQMAQQ----LAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2415

Query: 285  -----RASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIV 339
                 RA AR    A          G     T +    +   +  L    Q + H    +
Sbjct: 2416 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2475

Query: 340  RQVRAERGLRGVPERDRKIAALMLARHQE------ELLLLEQRAAAHGQWELQRVHAKQR 393
            R+  AE  L    E+ ++ A L+  + +E      E LL E +A    Q  L    +  +
Sbjct: 2476 REAIAE--LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQ 2531

Query: 394  REREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQG 453
            RER   +++  LEQ  +   A+ ++ R  + R++++  + RQR     EE RR       
Sbjct: 2532 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR------- 2584

Query: 454  LLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQ 513
                            R+ + E+ +++++E LQ+     EQ RR++ +  A   QR   Q
Sbjct: 2585 ----------------RQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLREQ 2624

Query: 514  LQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLER 573
            LQ    E  RA  A  E +   +    +    G R +L+     A+  +    + RK+  
Sbjct: 2625 LQL-LEEQHRAALAHSEEVTASQVAATKTLPNG-RDALDGPAAEAEPEHSFDGLRRKVS- 2681

Query: 574  SEQLTRERRSALESARSTARASFHVREKVREE 605
            +++L      + E  +  A+    V E  R E
Sbjct: 2682 AQRLQEAGILSAEELQRLAQGHTTVDELARRE 2713



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 81/342 (23%), Positives = 131/342 (38%), Gaps = 78/342 (22%)

Query: 331  TAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHA 390
            +A ++E++       RG +G  E        +L  H+E+L   E +A      EL+   A
Sbjct: 1108 SAIYLEKLKTISLVIRGTQGAEE--------VLRAHEEQLK--EAQAVPATLPELEATKA 1157

Query: 391  KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAE 450
              ++ R + E Q+      R      +E RG +   ER     +QR  ER  E  R    
Sbjct: 1158 SLKKLRAQAEAQQPTFDALR------DELRGAQEVGER----LQQRHGERDVEVERWRER 1207

Query: 451  RQGLLRRERAERAAREDRLRKLQQ------------------EQNLKQREEGLQ-----E 487
               LL R +A  A  + R R+L+Q                   Q+ ++R+E +Q     +
Sbjct: 1208 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1267

Query: 488  GRERAEQIRRERA---------------QRAAR----AKQRQEGQLQREKRELSRAERAR 528
             +   EQ+R+E+A               QR A+    A +  E QL   K +L       
Sbjct: 1268 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1327

Query: 529  HEALLQGRTRQQRQEREGLRSSLE-------------ASLGRAQENYEHLAIGRKLERSE 575
             +  +Q  +    QE   LR+                +   R  E  E LA  ++ E  E
Sbjct: 1328 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1387

Query: 576  QLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVRE 617
            +L  E  +ALE  R  A A  H + K + E   +   + ++E
Sbjct: 1388 RLA-EVEAALEKQRQLAEA--HAQAKAQAEREAKELQQRMQE 1426


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 94/349 (26%), Positives = 135/349 (38%), Gaps = 39/349 (11%)

Query: 220 RAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRE 279
           R +R+        +    P  SR+ R +H       R            S SY    LRE
Sbjct: 477 RDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLRE 536

Query: 280 LRWPPRASARNSCPAGSASSTTN-----APGRPSALTLVPITGRSFSLGDL--SHSPQTA 332
                R   RN     S S   N     + GR   L   P  G   S G    SHS  + 
Sbjct: 537 ES--SRTEIRNESRNESRSEIRNDRMGRSRGRVPEL---PEKGSRGSRGSQIDSHSSNSN 591

Query: 333 QHVERIVRQVRAERGLRGVPERDRKIAALMLA---RHQEELLLLEQRAAAHGQWELQRVH 389
            H     R    ER     PERD +  A   +   RH E      +         ++   
Sbjct: 592 YHDSWETRSSYPERDR--YPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQG 649

Query: 390 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRREL 448
                ER+ER ++R +++        V++RR  R RE +RE  R R+R+ ER  ER RE 
Sbjct: 650 RNDELERDERREERRVDR--------VDDRRDERARERDRERERDRERERERERERDRE- 700

Query: 449 AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQ 508
            E++  L RERA    RE            +++E   +  R+R     RER +   R K+
Sbjct: 701 REKERELERERARERERE------------REKERDRERDRDRDHDRERERERERDREKE 748

Query: 509 RQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGR 557
           R+  + +RE+      ER R     + R R++ +ERE  R   +   GR
Sbjct: 749 REREREERERERERERERERERERERERARERDKERERQRDWEDKDKGR 797



 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 71/276 (25%), Positives = 126/276 (45%), Gaps = 42/276 (15%)

Query: 386 QRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGRE-----EREAARRRQRQYER 440
           +R   ++R    EREK+R LE+ R     +  E+   R R+     +RE  R R+R  E+
Sbjct: 688 ERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREK 747

Query: 441 SEERRRELAERQGLLRRERAERAARE-----DRLRKLQQEQNLKQREEGLQEGRERAEQI 495
             ER RE  ER+    RER     RE     +R ++ +++++ + +++G  + RE+ E+I
Sbjct: 748 EREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEI 807

Query: 496 RRER------AQRAARAKQRQEG-----QLQREKRELSRAERA---------RHEALLQ- 534
           R +R       +R ++ + R EG     Q  + +RE S    A         +H  L Q 
Sbjct: 808 REDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQV 867

Query: 535 GRTRQQR--------QEREGLRSSLEASLGRAQEN--YEHLAIGRKLERSEQLTRERRSA 584
            R ++ R        ++R+G     +    R + +  YE   +  K+  S    RE+   
Sbjct: 868 VRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVS-SVDKQREQTEI 926

Query: 585 LESARSTARASFHVREKVREETNTRSFDRMVREAQL 620
           LES+R  A+      +    ET+ R+ D   ++A++
Sbjct: 927 LESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKI 962



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 59/206 (28%), Positives = 95/206 (46%), Gaps = 21/206 (10%)

Query: 345 ERGLRGVPERDRKIAALMLARHQ---EELLLLEQRAAAHGQWELQRV-HAKQRREREERE 400
           ER  R   ERD++ ++ +  RHQ   +EL   E+R       E +RV     RR+   RE
Sbjct: 628 ERDRRDNRERDQRPSSPI--RHQGRNDELERDERR-------EERRVDRVDDRRDERARE 678

Query: 401 KQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERA 460
           + R  E+ R     + E  R R   +ERE  R R R+ ER  E+ R+    +        
Sbjct: 679 RDRERERDRER-ERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRER 737

Query: 461 ERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRE 520
           ER    DR ++ ++E+  ++RE   +  RER  +  RERA+   + ++RQ     ++K  
Sbjct: 738 ERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGR 797

Query: 521 LSRAERARHEALLQGRTRQQRQEREG 546
             R E+       +   R+ R  R+G
Sbjct: 798 DDRREK-------REEIREDRNPRDG 816



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 115/492 (23%), Positives = 175/492 (35%), Gaps = 53/492 (10%)

Query: 168 ERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASP 227
           +R R    ++ +   P S + A    +  +S   + SS S SS     SP+PR  RK +P
Sbjct: 299 DRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRH-SPSPR--RKRTP 355

Query: 228 SPSSARTQPPPAG-SRTGRKSHSLDSLSRR----REGALSSESGASSSSYSGESLRELRW 282
           SPS  RT  PP   S +   SHSL S  R+    R  +   E G      + +S  + R 
Sbjct: 356 SPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQS-HDRRH 414

Query: 283 PPRASARNSCPAGSAS------STTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVE 336
             R   R        S          +  R       P  GR     D   +  T    E
Sbjct: 415 ERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGR-----DRRDARDTRDRRE 469

Query: 337 -RIVRQVRAERGLRGVPE-----RDRKIAALMLARH------------QEELLLLEQRAA 378
            R  R +R  R +R         RD + +      H            +E+    E R+ 
Sbjct: 470 LRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSY 529

Query: 379 A--HGQWELQRVHAKQRREREEREKQRALEQGR-RAWAAQVEERRGRRGREEREAARRRQ 435
              H + E  R   +     E R + R    GR R    ++ E+  R  R  +  +    
Sbjct: 530 GRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSN 589

Query: 436 RQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQI 495
             Y  S E R    ER     R+  ++A      R+  +      RE   +       Q 
Sbjct: 590 SNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQG 649

Query: 496 RRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASL 555
           R +  +R  R ++R+  ++        R ERAR     + R R++ +ERE  R       
Sbjct: 650 RNDELERDERREERRVDRVDDR-----RDERARERDRERERDRERERERERERD------ 698

Query: 556 GRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMV 615
            R +E    L   R  ER  +  +ER    +  R   R     RE+ RE+   R  +   
Sbjct: 699 -REREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERE 757

Query: 616 REAQLHASLDRK 627
           RE +     +R+
Sbjct: 758 RERERERERERE 769



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 62/240 (25%), Positives = 103/240 (42%), Gaps = 28/240 (11%)

Query: 380 HGQWELQRVHAKQRR--EREEREKQRALEQGRRAWAAQVEERRGRRGREEREAA--RRRQ 435
           H  WE +  + ++ R  ER+ R++ R     RR       +RR  R R++R ++  R + 
Sbjct: 593 HDSWETRSSYPERDRYPERDNRDQARDSSFERRHGE---RDRRDNRERDQRPSSPIRHQG 649

Query: 436 RQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQI 495
           R  E   + RRE   R   +   R ERA   DR R+  +E+  ++RE      RE+  ++
Sbjct: 650 RNDELERDERRE-ERRVDRVDDRRDERARERDRERERDRERE-RERERERDREREKEREL 707

Query: 496 RRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASL 555
            RERA+   R ++++        R+  R     H+     R R++ +ER+  +       
Sbjct: 708 ERERAREREREREKE--------RDRERDRDRDHD-----RERERERERDREKERERERE 754

Query: 556 GRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARAS------FHVREKVREETNTR 609
            R +E        R+ ER  +  RER    E  R               RE++RE+ N R
Sbjct: 755 ERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPR 814



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 90/419 (21%), Positives = 159/419 (37%), Gaps = 50/419 (11%)

Query: 184  LSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRT 243
            L P     A A A + P+  ++++ ++A+  ++ A   +  A+P+ ++  T    A   +
Sbjct: 1100 LLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTF---ANEDS 1156

Query: 244  GRKSHSL-------------DSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARN 290
             RK H               D+  R+      S S  S+ S    +   LR P   SA  
Sbjct: 1157 HRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHR 1216

Query: 291  SCPAGSASSTTNAPG---RPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERG 347
            S    S        G   R    +L  ITG   S  D     + ++      +  R+   
Sbjct: 1217 SGDDQSGRKRVLHSGSRDREKTKSL-EITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSS 1275

Query: 348  LRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQ 407
             R  PE DR++ +   +    + L    R      +E  R   ++RR+  +RE  R  ++
Sbjct: 1276 RRSSPESDRQVHSRSGSFDSRDRLQERDR------YEHDRERERERRDTRQREWDRDADK 1329

Query: 408  GRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAARED 467
                W               R+  R R+R+ ER  ++RR+L   +  L  +  ER    D
Sbjct: 1330 D---WP------------RNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRD 1374

Query: 468  RLRKLQQEQ--NLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREK--RELSR 523
            R R  +  Q  ++K+ E  L+   ER   +        A  K+R +  L   +   E ++
Sbjct: 1375 RDRTFESSQIESVKRCEAKLEGEHER--DLESTSRDSLALDKERMDKDLGSVQGFEETNK 1432

Query: 524  AERARHEALLQGRTRQQRQEREGLRSSL-EASLGRAQENYEHLAIGRKLERSEQLTRER 581
            +ER   E+L  G    +  +   L S   E     + +  + +  G   +R +Q   E+
Sbjct: 1433 SERT--ESLEAGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEK 1489


>gi|224593756 hypothetical protein LOC164127 [Homo sapiens]
          Length = 623

 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 72/272 (26%), Positives = 130/272 (47%), Gaps = 4/272 (1%)

Query: 351 VPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRR 410
           V  +D++I AL+L R ++   + E +  A   WE  +   ++ +   ERE++  L Q + 
Sbjct: 252 VSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQE 311

Query: 411 AWAAQVEERRGRRGREEREAARRRQRQ-YERSEERRRELAERQGLLRRERAERAAREDRL 469
            W  + E+R+  +  E+R   R  QR+     E R +E  E Q   R+E+ E+A  +   
Sbjct: 312 QW-QEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEH 370

Query: 470 RKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARH 529
           RK  Q + L+++E+ L+  RE+     + R   A R +     + Q++ ++ + +    +
Sbjct: 371 RKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINY 430

Query: 530 EALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESAR 589
           +A       Q + E    + SLE S  R+QE ++ L   R+ E  E+  +E    L+ AR
Sbjct: 431 QARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQ-LQQAR 489

Query: 590 STARASFHVREKVREETNTRSFDRMVREAQLH 621
             A  S   R K+R+       D  +R+A+ H
Sbjct: 490 WRAGESEEQR-KMRKRILVELADEKIRQARSH 520


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 68/255 (26%), Positives = 110/255 (43%), Gaps = 20/255 (7%)

Query: 358 IAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVE 417
           I A+ +   + +L+  E         +L+    K+ +ER+E EK+R   +  R      E
Sbjct: 264 INAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERER------E 317

Query: 418 ERRGRRGRE-EREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQ 476
             R RR RE ERE  R R+++ ER  ER R+    +   R    +R    DR R+   ++
Sbjct: 318 RERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDR 377

Query: 477 NLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGR 536
           N K R    ++ R+R  +  RER +   R ++R     +RE+      ER R     + R
Sbjct: 378 N-KDRSRSREKSRDRERERERERERERERERER-----EREREREREREREREREKDKKR 431

Query: 537 TRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASF 596
            R++ +E    R  LE  L   +  Y+      +L+  E   RER+   E  +   R   
Sbjct: 432 DREEDEEDAYERRKLERKLREKEAAYQ-----ERLKNWE--IRERKKTREYEKEAEREEE 484

Query: 597 HVREKVREETNTRSF 611
             RE  +E    + F
Sbjct: 485 RRREMAKEAKRLKEF 499



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 50/213 (23%), Positives = 97/213 (45%), Gaps = 15/213 (7%)

Query: 349 RGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQG 408
           +G  E++R+   +   R + E     +R     + E +R   +++ +  ERE++R  ++ 
Sbjct: 295 KGKKEKERQ--EIEKERRERERERERERERREREREREREREREKEKERERERERDRDRD 352

Query: 409 RRAWAAQVEERRGRRGRE---------EREAARRRQRQYERSEERRRELAERQGLLRRER 459
           R     +  +R   R R+         +R  +R + R  ER  ER RE  ER+    RER
Sbjct: 353 RTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERE-RERERERERER 411

Query: 460 AERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKR 519
                RE    + +++   + REE  ++  ER +  R+ R + AA  ++ +  +++  K+
Sbjct: 412 EREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKK 471

Query: 520 ELSRAERARHEALLQGRTRQQRQEREGLRSSLE 552
                + A  E   + R R+  +E + L+  LE
Sbjct: 472 TREYEKEAERE---EERRREMAKEAKRLKEFLE 501



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 74/302 (24%), Positives = 116/302 (38%), Gaps = 38/302 (12%)

Query: 339 VRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREE 398
           + + R ER      ER+R+       R +E     E+        +  R   + R    E
Sbjct: 305 IEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRE 364

Query: 399 REKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRRE---------- 447
           R++ R  E+       +   R   R RE ERE  R R+R+ ER  ER RE          
Sbjct: 365 RDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERERERE 424

Query: 448 ---------------LAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERA 492
                            ER+ L R+ R + AA ++RL+  +  +  K RE   ++  ER 
Sbjct: 425 REKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTRE--YEKEAERE 482

Query: 493 EQIRRERAQRAARAKQ--------RQEGQLQREKRELSRAERARHEALLQGRTR-QQRQE 543
           E+ RRE A+ A R K+        R + +  R      R      E     R R ++++E
Sbjct: 483 EERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEE 542

Query: 544 REGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVR 603
            E +R  L A  G    + E   + ++ ER  Q   ++    E      +     RE+  
Sbjct: 543 LEEIRQRLLAE-GHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPM 601

Query: 604 EE 605
           EE
Sbjct: 602 EE 603



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 51/189 (26%), Positives = 84/189 (44%), Gaps = 12/189 (6%)

Query: 442 EERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE--EGLQEGRERAEQIRRER 499
           EE +R+L  R         E +   D  +KL++E+  K++E  E  +E RER  +  RER
Sbjct: 270 EEDKRDLISR---------EISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERER 320

Query: 500 AQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEAS-LGRA 558
            +R    ++ +E + ++EK      ER R     + R R + +ER+  R    +S   + 
Sbjct: 321 ERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKD 380

Query: 559 QENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREA 618
           +      +  R+ ER  +  RER    E  R   R     RE+ RE+   R  +    +A
Sbjct: 381 RSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDA 440

Query: 619 QLHASLDRK 627
                L+RK
Sbjct: 441 YERRKLERK 449



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 51/206 (24%), Positives = 89/206 (43%), Gaps = 45/206 (21%)

Query: 415 QVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQ 474
           ++EE +G++ +E +E  + R+   ER  ER RE         RER ER    +R R+ ++
Sbjct: 290 KLEEEKGKKEKERQEIEKERR---ERERERERE---------RERREREREREREREREK 337

Query: 475 EQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQ 534
           E+  ++RE      R+R ++  R+R +   R + R+    + + R  SR +         
Sbjct: 338 EKE-RERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREK--------- 387

Query: 535 GRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARA 594
            R R++ +ERE                       R+ ER  +  RER    E  R   R 
Sbjct: 388 SRDRERERERE-----------------------RERERERERERERERERERERERERE 424

Query: 595 SFHVREKVREETNTRSFDRMVREAQL 620
               +++ REE    +++R   E +L
Sbjct: 425 REKDKKRDREEDEEDAYERRKLERKL 450



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 53/210 (25%), Positives = 91/210 (43%), Gaps = 33/210 (15%)

Query: 365 RHQEELLLLEQRAAAHGQWELQRVHAK-QRREREEREK----QRALEQGRRAWAAQVEER 419
           R +E     E+      + E +R   K ++R+REE E+    +R LE+  R   A  +ER
Sbjct: 401 REREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQER 460

Query: 420 RGRRGREEREAARRRQRQYERSEERRRELAERQGLLR----------------------- 456
                  ER+  R  +++ ER EERRRE+A+    L+                       
Sbjct: 461 LKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQK 520

Query: 457 --RERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQ---RQE 511
             R+R +    ++R RK ++E+  + R+  L EG    +   +   Q A R +Q   +QE
Sbjct: 521 RLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQE 580

Query: 512 GQLQREKRELSRAERARHEALLQGRTRQQR 541
            + + E+ E    E  R E + +    +Q+
Sbjct: 581 PESEEEEEEKQEKEEKREEPMEEEEEPEQK 610



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 47/186 (25%), Positives = 82/186 (44%), Gaps = 12/186 (6%)

Query: 436 RQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQI 495
           R+  +  +  ++L E +G   +ER E   +E R R+ ++E+  ++RE   +  RER  + 
Sbjct: 279 REISKFRDTHKKLEEEKGKKEKERQE-IEKERRERERERERERERREREREREREREREK 337

Query: 496 RRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRS-SLEAS 554
            +ER          +E +  R++      +R R     + R R++  +R   RS S E S
Sbjct: 338 EKER---------ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKS 388

Query: 555 LGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTARASFHVREKVREET-NTRSFDR 613
             R +E        R+ ER  +  RER    E  R   +     RE+  E+    R  +R
Sbjct: 389 RDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLER 448

Query: 614 MVREAQ 619
            +RE +
Sbjct: 449 KLREKE 454



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 11/85 (12%)

Query: 353 ERDRKIAALMLARHQEELLLLEQRAAAHGQ----WELQRVHAKQRREREEREKQRALEQG 408
           ERDRK       R +EEL  + QR  A G      ELQR+  +  R R+ + KQ    + 
Sbjct: 533 ERDRK-------REKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEE 585

Query: 409 RRAWAAQVEERRGRRGREEREAARR 433
                 + EE+R     EE E  ++
Sbjct: 586 EEEEKQEKEEKREEPMEEEEEPEQK 610


>gi|219803769 trichoplein [Homo sapiens]
          Length = 498

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 89/332 (26%), Positives = 145/332 (43%), Gaps = 57/332 (17%)

Query: 318 RSFSLGDLSHSPQTA--------QHVERIVRQVRAERGLRGVPERDRKIAALM------L 363
           R F + D+  S Q          + +    R+   E   R +  R  K+  LM      L
Sbjct: 39  RYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLL 98

Query: 364 ARHQEELLL---LEQRAAAHGQWELQRVHAKQRREREE--------------REKQRALE 406
           AR  EEL L   L++R       +L+    +QR+   E              RE +  L 
Sbjct: 99  ARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLH 158

Query: 407 QGR--RAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAA 464
           Q     +W  Q EE++ +    E+E  +R + +YER+   RRE  ER     +   ER  
Sbjct: 159 QKHVVNSWEMQKEEKKQQEATAEQEN-KRYENEYERA---RREALERM----KAEEERRQ 210

Query: 465 REDRLRK---LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKREL 521
            ED+L+    LQQ + LK +E    + ++  E + ++R +     ++R++ +  R+K EL
Sbjct: 211 LEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAEL 270

Query: 522 SRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-HLA-----------IGR 569
            R  R ++ A L  RT+Q ++E E  R  L+A L +  E+   HLA           + +
Sbjct: 271 GRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQ 330

Query: 570 KLERSEQLTRERRSALES-ARSTARASFHVRE 600
            +E   QL R R + L+   R  A+  +  RE
Sbjct: 331 AIEEQLQLERAREAELQMLLREEAKEMWEKRE 362



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 71/256 (27%), Positives = 123/256 (48%), Gaps = 27/256 (10%)

Query: 341 QVRAERGLRGVPE-RDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
           +++AE  L+ + E + +++ A  L + QE LL  +QR      WEL+R+  ++++    R
Sbjct: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLL--KQR------WELERLEEERKQMEAFR 265

Query: 400 EKQRALEQGRRAWAAQVEERRGRRGREEREAARR-RQRQYERSEERRR-ELAERQGLLRR 457
           +K       R  + AQ+  RR ++ +EE EA RR  Q   E+ +E +R  LA R+ ++  
Sbjct: 266 QKAELGRFLRHQYNAQLS-RRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMAD 324

Query: 458 ERAERAAREDRL---RKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQL 514
               + A E++L   R  + E  +  REE  +   +R  +  RER+ R     +   G+ 
Sbjct: 325 VAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQ 384

Query: 515 QREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE---ASLGRAQENYEHLAIGRKL 571
           Q+ + ++ +  RA+ E+L         + RE L  +LE       R +E  E L   RK 
Sbjct: 385 QQIQEKIEQNRRAQEESL---------KHREQLIRNLEEVRELARREKEESEKLKSARKQ 435

Query: 572 ERSEQLTRERRSALES 587
           E   Q+   R  A E+
Sbjct: 436 ELEAQVAERRLQAWEA 451



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 57/215 (26%), Positives = 98/215 (45%), Gaps = 30/215 (13%)

Query: 327 HSPQTAQHVERIVRQVRAERG-LRGVPERDRKIAALMLARHQ-------------EELLL 372
           ++ Q ++  ++I  ++ A+R  L+ + E++ +   L LAR +             EE L 
Sbjct: 278 YNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337

Query: 373 LEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR 432
           LE+   A  Q  L R  AK+  E+ E E  R     R    ++V   R ++ +E+ E  R
Sbjct: 338 LERAREAELQM-LLREEAKEMWEKREAEWARE-RSARDRLMSEVLTGRQQQIQEKIEQNR 395

Query: 433 RRQRQ-YERSEERRRELAERQGLLRRERAE----RAAREDRLRKLQQEQNLKQREEGLQE 487
           R Q +  +  E+  R L E + L RRE+ E    ++AR+  L     E+ L+  E     
Sbjct: 396 RAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWE----- 450

Query: 488 GRERAEQIRRERAQRAARAKQRQEGQLQREKRELS 522
               A+Q   E  + A R +Q  +  LQ+E   ++
Sbjct: 451 ----ADQQEEEEEEEARRVEQLSDALLQQEAETMA 481



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 39/220 (17%), Positives = 98/220 (44%), Gaps = 19/220 (8%)

Query: 412 WAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRK 471
           W +Q  +R  ++   +RE   R ++Q+E++    R +++     + E + + + +  +  
Sbjct: 10  WCSQ--QRLNQQLARQREQEARLRQQWEQNSRYFR-MSDICSSKQAEWSSKTSYQRSMHA 66

Query: 472 LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR-------QEGQLQREKRELSRA 524
            Q+E+  +++   L+  RE+  Q+ +E     AR  +        QE +++ +  +L  A
Sbjct: 67  YQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSA 126

Query: 525 ERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSA 584
           +  + + + +    +  ++       +E  L     + +H+    ++++ E+  +E  + 
Sbjct: 127 KEEQRKLIAEQLLYEHWKKNNPKLREMELDL-----HQKHVVNSWEMQKEEKKQQEATAE 181

Query: 585 LESAR---STARASFHVREKVREETNTRSF-DRMVREAQL 620
            E+ R      RA     E+++ E   R   D++  EA L
Sbjct: 182 QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALL 221



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 36/122 (29%), Positives = 55/122 (45%), Gaps = 19/122 (15%)

Query: 354 RDRKIAALMLARHQEELLLLEQRAAAHGQW---------ELQRVHAKQRREREEREKQRA 404
           RDR ++ ++  R Q+    +EQ   A  +           L+ V    RRE+EE EK ++
Sbjct: 372 RDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKS 431

Query: 405 LEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAA 464
               ++   AQV ERR        +A    Q++ E  EE RR       LL++E AE  A
Sbjct: 432 AR--KQELEAQVAERR-------LQAWEADQQEEEEEEEARRVEQLSDALLQQE-AETMA 481

Query: 465 RE 466
            +
Sbjct: 482 EQ 483


>gi|14150056 trichoplein [Homo sapiens]
          Length = 498

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 89/332 (26%), Positives = 145/332 (43%), Gaps = 57/332 (17%)

Query: 318 RSFSLGDLSHSPQTA--------QHVERIVRQVRAERGLRGVPERDRKIAALM------L 363
           R F + D+  S Q          + +    R+   E   R +  R  K+  LM      L
Sbjct: 39  RYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLL 98

Query: 364 ARHQEELLL---LEQRAAAHGQWELQRVHAKQRREREE--------------REKQRALE 406
           AR  EEL L   L++R       +L+    +QR+   E              RE +  L 
Sbjct: 99  ARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLH 158

Query: 407 QGR--RAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAA 464
           Q     +W  Q EE++ +    E+E  +R + +YER+   RRE  ER     +   ER  
Sbjct: 159 QKHVVNSWEMQKEEKKQQEATAEQEN-KRYENEYERA---RREALERM----KAEEERRQ 210

Query: 465 REDRLRK---LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKREL 521
            ED+L+    LQQ + LK +E    + ++  E + ++R +     ++R++ +  R+K EL
Sbjct: 211 LEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAEL 270

Query: 522 SRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE-HLA-----------IGR 569
            R  R ++ A L  RT+Q ++E E  R  L+A L +  E+   HLA           + +
Sbjct: 271 GRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQ 330

Query: 570 KLERSEQLTRERRSALES-ARSTARASFHVRE 600
            +E   QL R R + L+   R  A+  +  RE
Sbjct: 331 AIEEQLQLERAREAELQMLLREEAKEMWEKRE 362



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 71/256 (27%), Positives = 123/256 (48%), Gaps = 27/256 (10%)

Query: 341 QVRAERGLRGVPE-RDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREER 399
           +++AE  L+ + E + +++ A  L + QE LL  +QR      WEL+R+  ++++    R
Sbjct: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLL--KQR------WELERLEEERKQMEAFR 265

Query: 400 EKQRALEQGRRAWAAQVEERRGRRGREEREAARR-RQRQYERSEERRR-ELAERQGLLRR 457
           +K       R  + AQ+  RR ++ +EE EA RR  Q   E+ +E +R  LA R+ ++  
Sbjct: 266 QKAELGRFLRHQYNAQLS-RRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMAD 324

Query: 458 ERAERAAREDRL---RKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQL 514
               + A E++L   R  + E  +  REE  +   +R  +  RER+ R     +   G+ 
Sbjct: 325 VAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQ 384

Query: 515 QREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLE---ASLGRAQENYEHLAIGRKL 571
           Q+ + ++ +  RA+ E+L         + RE L  +LE       R +E  E L   RK 
Sbjct: 385 QQIQEKIEQNRRAQEESL---------KHREQLIRNLEEVRELARREKEESEKLKSARKQ 435

Query: 572 ERSEQLTRERRSALES 587
           E   Q+   R  A E+
Sbjct: 436 ELEAQVAERRLQAWEA 451



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 57/215 (26%), Positives = 98/215 (45%), Gaps = 30/215 (13%)

Query: 327 HSPQTAQHVERIVRQVRAERG-LRGVPERDRKIAALMLARHQ-------------EELLL 372
           ++ Q ++  ++I  ++ A+R  L+ + E++ +   L LAR +             EE L 
Sbjct: 278 YNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337

Query: 373 LEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAAR 432
           LE+   A  Q  L R  AK+  E+ E E  R     R    ++V   R ++ +E+ E  R
Sbjct: 338 LERAREAELQM-LLREEAKEMWEKREAEWARE-RSARDRLMSEVLTGRQQQIQEKIEQNR 395

Query: 433 RRQRQ-YERSEERRRELAERQGLLRRERAE----RAAREDRLRKLQQEQNLKQREEGLQE 487
           R Q +  +  E+  R L E + L RRE+ E    ++AR+  L     E+ L+  E     
Sbjct: 396 RAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWE----- 450

Query: 488 GRERAEQIRRERAQRAARAKQRQEGQLQREKRELS 522
               A+Q   E  + A R +Q  +  LQ+E   ++
Sbjct: 451 ----ADQQEEEEEEEARRVEQLSDALLQQEAETMA 481



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 39/220 (17%), Positives = 98/220 (44%), Gaps = 19/220 (8%)

Query: 412 WAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRK 471
           W +Q  +R  ++   +RE   R ++Q+E++    R +++     + E + + + +  +  
Sbjct: 10  WCSQ--QRLNQQLARQREQEARLRQQWEQNSRYFR-MSDICSSKQAEWSSKTSYQRSMHA 66

Query: 472 LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR-------QEGQLQREKRELSRA 524
            Q+E+  +++   L+  RE+  Q+ +E     AR  +        QE +++ +  +L  A
Sbjct: 67  YQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSA 126

Query: 525 ERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSA 584
           +  + + + +    +  ++       +E  L     + +H+    ++++ E+  +E  + 
Sbjct: 127 KEEQRKLIAEQLLYEHWKKNNPKLREMELDL-----HQKHVVNSWEMQKEEKKQQEATAE 181

Query: 585 LESAR---STARASFHVREKVREETNTRSF-DRMVREAQL 620
            E+ R      RA     E+++ E   R   D++  EA L
Sbjct: 182 QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALL 221



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 36/122 (29%), Positives = 55/122 (45%), Gaps = 19/122 (15%)

Query: 354 RDRKIAALMLARHQEELLLLEQRAAAHGQW---------ELQRVHAKQRREREEREKQRA 404
           RDR ++ ++  R Q+    +EQ   A  +           L+ V    RRE+EE EK ++
Sbjct: 372 RDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKS 431

Query: 405 LEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAA 464
               ++   AQV ERR        +A    Q++ E  EE RR       LL++E AE  A
Sbjct: 432 AR--KQELEAQVAERR-------LQAWEADQQEEEEEEEARRVEQLSDALLQQE-AETMA 481

Query: 465 RE 466
            +
Sbjct: 482 EQ 483


>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
           [Homo sapiens]
          Length = 213

 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 53/194 (27%), Positives = 87/194 (44%), Gaps = 5/194 (2%)

Query: 391 KQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA- 449
           ++RR   +RE+ RA E       ++ + +R R    ER+  R R++Q +R  ER+RE   
Sbjct: 21  RERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRERER 80

Query: 450 --ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAK 507
             +RQ    RER +    +      ++ Q  K+RE      RER +Q    R ++  R  
Sbjct: 81  DRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDRET 140

Query: 508 QRQEGQLQREKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAI 567
            R+  +    +RE  R  +   E   + R R++++ERE  R + E       E       
Sbjct: 141 DRERERQAERERETGRERKT--EDRHRERERERKRERERKRETKERERHTDMERERQRET 198

Query: 568 GRKLERSEQLTRER 581
            RK +R  +  RER
Sbjct: 199 DRKRDRQRESERER 212



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 57/214 (26%), Positives = 92/214 (42%), Gaps = 13/214 (6%)

Query: 334 HVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQR 393
           H E      + ER      ERDR   +    RH E     +++       E  R   +++
Sbjct: 11  HTETETMDRQRERRRETDRERDRAKESKTEDRHSER----DRQRDRERNRERDRDREREK 66

Query: 394 REREEREKQRALEQGRRAWAAQVEERRGRRGRE-EREAARRRQRQYERSEERRRELAERQ 452
           +   E E+QR  E+ R        +R   R R+ ERE  R  +   ER +++ RE+ ER 
Sbjct: 67  QTDREGERQRERERDRD------RQRETERERDKERETDRHTETDRERQKQKEREM-ERV 119

Query: 453 GLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRER-AEQIRRERAQRAARAKQRQE 511
               RE+ +   RE +  +    +  +Q E   + GRER  E   RER +   R ++R+ 
Sbjct: 120 RDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKR 179

Query: 512 GQLQREKRELSRAERARHEALLQGRTRQQRQERE 545
              +RE+      ER R     + R R+  +ER+
Sbjct: 180 ETKERERHTDMERERQRETDRKRDRQRESERERD 213



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 53/207 (25%), Positives = 87/207 (42%), Gaps = 23/207 (11%)

Query: 424 GREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREE 483
           GR          RQ ER  E  RE         R+RA+ +  EDR  +  ++++ ++R  
Sbjct: 7   GRHTHTETETMDRQRERRRETDRE---------RDRAKESKTEDRHSERDRQRD-RERNR 56

Query: 484 GLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQE 543
                RER +Q  RE  ++  R + R + Q + E+      E  RH    + R +Q+ +E
Sbjct: 57  ERDRDREREKQTDREGERQRERERDR-DRQRETERERDKERETDRHTETDRERQKQKERE 115

Query: 544 REGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTAR---ASFHVRE 600
            E +R          +E  +   +GR+ +   +  RER    E  R T R        RE
Sbjct: 116 MERVRD---------REREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRE 166

Query: 601 KVREETNTRSFDRMVREAQLHASLDRK 627
           + RE    R   R  +E + H  ++R+
Sbjct: 167 RERERKRERERKRETKERERHTDMERE 193



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 63/236 (26%), Positives = 96/236 (40%), Gaps = 40/236 (16%)

Query: 389 HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRREL 448
           H     E  +R+++R  E  R        +R      E+R + R RQR  ER+ ER R+ 
Sbjct: 9   HTHTETETMDRQRERRRETDRE------RDRAKESKTEDRHSERDRQRDRERNRERDRD- 61

Query: 449 AERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRER--AQRAARA 506
                   RER ++  RE            +QRE   +  R+R  +  RER   +   R 
Sbjct: 62  --------REREKQTDREGE----------RQRER--ERDRDRQRETERERDKERETDRH 101

Query: 507 KQRQEGQLQREKRELSRA-ERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHL 565
            +    + ++++RE+ R  +R R +    GR RQ  +E +  R        R  E     
Sbjct: 102 TETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERE-------RQAERERET 154

Query: 566 AIGRKLE-RSEQLTRERRSALESARSTARASFHV-REKVREETNTRSFDRMVREAQ 619
              RK E R  +  RER+   E  R T     H   E+ R+    R  DR  RE++
Sbjct: 155 GRERKTEDRHRERERERKRERERKRETKERERHTDMERERQRETDRKRDRQ-RESE 209



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 28/114 (24%), Positives = 43/114 (37%), Gaps = 11/114 (9%)

Query: 517 EKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQ 576
           E +   R      E + + R R++  +RE  R+    +  R  E        R  +R  +
Sbjct: 2   ESKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSE--------RDRQRDRE 53

Query: 577 LTRERRSALESARSTARASFHVREKVREETNTRSFDR---MVREAQLHASLDRK 627
             RER    E  + T R     RE+ R+    R  +R     RE   H   DR+
Sbjct: 54  RNRERDRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRE 107


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 58/198 (29%), Positives = 100/198 (50%), Gaps = 13/198 (6%)

Query: 363 LARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGR 422
           L R   +L    Q   +  + E+QR   ++++ ++E E++R   +  R    ++E  R  
Sbjct: 120 LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERL--ERERMERERLERERLE 177

Query: 423 RGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQRE 482
           R R ERE   + Q + ER E  R+E  ERQ   R ER ER  R++RL + +QE+  ++R 
Sbjct: 178 RERLERERLEQEQLERERQERERQERLERQE--RLERQERLERQERLDRERQERQERERL 235

Query: 483 EGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQRQ 542
           E L+  RER E+ R+E+        +R++ + +RE+R  S A  A  E  L         
Sbjct: 236 ERLE--RERQERERQEQL-------EREQLEWERERRISSAAAPASVETPLNSVLGDSSA 286

Query: 543 EREGLRSSLEASLGRAQE 560
              GL+++ + +   +Q+
Sbjct: 287 SEPGLQAASQPAETPSQQ 304



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 47/151 (31%), Positives = 75/151 (49%), Gaps = 20/151 (13%)

Query: 473 QQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEAL 532
           Q+E  +++R+  LQE ++R +++ RER +R    ++R    L+RE+ E  R ER R E  
Sbjct: 137 QEELEIQRRQ--LQE-QQRQKELERERLERERMERER----LERERLERERLERERLEQE 189

Query: 533 LQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTA 592
              R RQ+R+ +E L            E  E L    +LER E+L RER+   E  R   
Sbjct: 190 QLERERQERERQERL------------ERQERLERQERLERQERLDRERQERQERER-LE 236

Query: 593 RASFHVREKVREETNTRSFDRMVREAQLHAS 623
           R     +E+ R+E   R      RE ++ ++
Sbjct: 237 RLERERQERERQEQLEREQLEWERERRISSA 267



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 50/165 (30%), Positives = 78/165 (47%), Gaps = 18/165 (10%)

Query: 466 EDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR------QEGQLQREKR 519
           E + R+LQ++Q    R++ L+  R   E++ RER +R    ++R      ++ QL+RE++
Sbjct: 141 EIQRRQLQEQQ----RQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196

Query: 520 ELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGR-KLERSEQLT 578
           E  R ER   +  L+ + R +RQE    R   E    + +E  E L   R + ER EQL 
Sbjct: 197 ERERQERLERQERLERQERLERQE----RLDRERQERQERERLERLERERQERERQEQLE 252

Query: 579 RERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHAS 623
           RE+   LE  R    +S      V    N+   D    E  L A+
Sbjct: 253 REQ---LEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAA 294



 Score = 38.1 bits (87), Expect = 0.025
 Identities = 35/117 (29%), Positives = 56/117 (47%), Gaps = 5/117 (4%)

Query: 330 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 389
           Q  + +ER   ++  ER  R   ER+R     +     E+  L  +R     Q  L+R  
Sbjct: 151 QRQKELER--ERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQE 208

Query: 390 AKQRREREEREKQRALEQGRRAWAAQVEE-RRGRRGREEREAARRRQRQYERSEERR 445
             +R+ER ER+++   E+  R    ++E   R R+ RE +E   R Q ++ER  ERR
Sbjct: 209 RLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWER--ERR 263



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 32/117 (27%), Positives = 47/117 (40%), Gaps = 20/117 (17%)

Query: 142 RSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAP- 200
           R  R+     E  E ER  +L++ R ERER  + E+ +L        ++AAA A+   P 
Sbjct: 218 RQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPL 277

Query: 201 ------SAGSSSSCSSASLPA-------------SPAPRAARKASPSPSSARTQPPP 238
                 S+ S     +AS PA             +P P       P+ +S    PPP
Sbjct: 278 NSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPP 334


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.124    0.338 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,159,584
Number of Sequences: 37866
Number of extensions: 1260449
Number of successful extensions: 42410
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 831
Number of HSP's successfully gapped in prelim test: 1725
Number of HSP's that attempted gapping in prelim test: 15116
Number of HSP's gapped (non-prelim): 12851
length of query: 627
length of database: 18,247,518
effective HSP length: 108
effective length of query: 519
effective length of database: 14,157,990
effective search space: 7347996810
effective search space used: 7347996810
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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