Guide to the Human Genome
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Search of human proteins with 239743724

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo
sapiens]
         (1415 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]     2805   0.0  
gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]     2805   0.0  
gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]     2354   0.0  
gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]     2274   0.0  
gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]     1942   0.0  
gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]     1926   0.0  
gi|154354990 ankyrin repeat domain 26 [Homo sapiens]                  527   e-149
gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sap...   369   e-102
gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sap...   369   e-101
gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo sa...   368   e-101
gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo sa...   367   e-101
gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member ...   353   6e-97
gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member ...   353   6e-97
gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens]       283   8e-76
gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo...   283   8e-76
gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo...   282   1e-75
gi|149363642 coiled-coil domain containing 144A [Homo sapiens]        271   3e-72
gi|239741279 PREDICTED: similar to FLJ00310 protein [Homo sapiens]    253   1e-66
gi|53828703 POTE ankyrin domain family, member A isoform 2 [Homo...   248   3e-65
gi|239745058 PREDICTED: hypothetical protein XP_002343353 [Homo ...   243   9e-64
gi|52856430 protein expressed in prostate, ovary, testis, and pl...   241   3e-63
gi|209977003 ANKRD26-like family C, member 3 [Homo sapiens]           241   3e-63
gi|52856434 POTE ankyrin domain family, member G [Homo sapiens]       240   6e-63
gi|239741769 PREDICTED: similar to protein expressed in prostate...   240   6e-63
gi|224282147 prostate-specific P704P [Homo sapiens]                   240   8e-63
gi|134133226 protein expressed in prostate, ovary, testis, and p...   239   1e-62
gi|153791352 prostate, ovary, testis expressed protein on chromo...   239   2e-62
gi|113413200 PREDICTED: similar to protein expressed in prostate...   238   2e-62
gi|88953571 PREDICTED: similar to protein expressed in prostate,...   238   2e-62
gi|239747812 PREDICTED: ankyrin repeat domain 36 [Homo sapiens]       236   1e-61

>gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
          Length = 1415

 Score = 2805 bits (7272), Expect = 0.0
 Identities = 1415/1415 (100%), Positives = 1415/1415 (100%)

Query: 1    MSPWLRPSQAVYPAAAAPGQEPTPQSHPRWLRRAPVSGPDLSSEEERVGSQGQAGPQAGR 60
            MSPWLRPSQAVYPAAAAPGQEPTPQSHPRWLRRAPVSGPDLSSEEERVGSQGQAGPQAGR
Sbjct: 1    MSPWLRPSQAVYPAAAAPGQEPTPQSHPRWLRRAPVSGPDLSSEEERVGSQGQAGPQAGR 60

Query: 61   DALLGFRDVPREPRRTRKPATRAPVLQVPPAGHEGLGAASGVPAVATMRKLFSFGRRLGQ 120
            DALLGFRDVPREPRRTRKPATRAPVLQVPPAGHEGLGAASGVPAVATMRKLFSFGRRLGQ
Sbjct: 61   DALLGFRDVPREPRRTRKPATRAPVLQVPPAGHEGLGAASGVPAVATMRKLFSFGRRLGQ 120

Query: 121  ALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLH 180
            ALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLH
Sbjct: 121  ALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLH 180

Query: 181  LACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIY 240
            LACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIY
Sbjct: 181  LACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIY 240

Query: 241  GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANI 300
            GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANI
Sbjct: 241  GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANI 300

Query: 301  HAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQIL 360
            HAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQIL
Sbjct: 301  HAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQIL 360

Query: 361  EHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQD 420
            EHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQD
Sbjct: 361  EHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQD 420

Query: 421  SQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSV 480
            SQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSV
Sbjct: 421  SQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSV 480

Query: 481  RLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEY 540
            RLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEY
Sbjct: 481  RLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEY 540

Query: 541  NEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRET 600
            NEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRET
Sbjct: 541  NEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRET 600

Query: 601  RDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELEN 660
            RDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELEN
Sbjct: 601  RDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELEN 660

Query: 661  LLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKE 720
            LLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKE
Sbjct: 661  LLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKE 720

Query: 721  KAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKH 780
            KAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKH
Sbjct: 721  KAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKH 780

Query: 781  EEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLN 840
            EEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLN
Sbjct: 781  EEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLN 840

Query: 841  TDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEK 900
            TDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEK
Sbjct: 841  TDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEK 900

Query: 901  DKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLE 960
            DKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLE
Sbjct: 901  DKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLE 960

Query: 961  QLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLM 1020
            QLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLM
Sbjct: 961  QLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLM 1020

Query: 1021 KSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLNSIELNRKYIPKTAIRIPT 1080
            KSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLNSIELNRKYIPKTAIRIPT
Sbjct: 1021 KSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLNSIELNRKYIPKTAIRIPT 1080

Query: 1081 SNPQTSNNCKNFLTEVLLCXALAPVYFLLXNPLHCLADLQLYTVPGFHLERVPALSALLG 1140
            SNPQTSNNCKNFLTEVLLC ALAPVYFLL NPLHCLADLQLYTVPGFHLERVPALSALLG
Sbjct: 1081 SNPQTSNNCKNFLTEVLLCXALAPVYFLLXNPLHCLADLQLYTVPGFHLERVPALSALLG 1140

Query: 1141 TPPLSASPGPPSVEREEIGEHLWEALILALGPGGDSDEDLGAPVSGAARPGQRSKTNKHT 1200
            TPPLSASPGPPSVEREEIGEHLWEALILALGPGGDSDEDLGAPVSGAARPGQRSKTNKHT
Sbjct: 1141 TPPLSASPGPPSVEREEIGEHLWEALILALGPGGDSDEDLGAPVSGAARPGQRSKTNKHT 1200

Query: 1201 HMYTHTRIHKHNACTHVSSGDRGHRLWALLTQAGSCCGGLCHPTMSLLLSPHRLCVVEQL 1260
            HMYTHTRIHKHNACTHVSSGDRGHRLWALLTQAGSCCGGLCHPTMSLLLSPHRLCVVEQL
Sbjct: 1201 HMYTHTRIHKHNACTHVSSGDRGHRLWALLTQAGSCCGGLCHPTMSLLLSPHRLCVVEQL 1260

Query: 1261 ETRSSLCEWLCMKDCFLGERHISTQLTDRTQQFHSASPLDTPRTXQDNPIMALSPGPVSL 1320
            ETRSSLCEWLCMKDCFLGERHISTQLTDRTQQFHSASPLDTPRT QDNPIMALSPGPVSL
Sbjct: 1261 ETRSSLCEWLCMKDCFLGERHISTQLTDRTQQFHSASPLDTPRTXQDNPIMALSPGPVSL 1320

Query: 1321 RDNQDAGPETTALLDAFNTVGELFANQPSQELDPVMDLLVLSLGHQVIILDIIHIHKEAL 1380
            RDNQDAGPETTALLDAFNTVGELFANQPSQELDPVMDLLVLSLGHQVIILDIIHIHKEAL
Sbjct: 1321 RDNQDAGPETTALLDAFNTVGELFANQPSQELDPVMDLLVLSLGHQVIILDIIHIHKEAL 1380

Query: 1381 TKVMESRQHVAEGKTEMQRLMTSESQEQDFFGHCG 1415
            TKVMESRQHVAEGKTEMQRLMTSESQEQDFFGHCG
Sbjct: 1381 TKVMESRQHVAEGKTEMQRLMTSESQEQDFFGHCG 1415


>gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
          Length = 1415

 Score = 2805 bits (7272), Expect = 0.0
 Identities = 1415/1415 (100%), Positives = 1415/1415 (100%)

Query: 1    MSPWLRPSQAVYPAAAAPGQEPTPQSHPRWLRRAPVSGPDLSSEEERVGSQGQAGPQAGR 60
            MSPWLRPSQAVYPAAAAPGQEPTPQSHPRWLRRAPVSGPDLSSEEERVGSQGQAGPQAGR
Sbjct: 1    MSPWLRPSQAVYPAAAAPGQEPTPQSHPRWLRRAPVSGPDLSSEEERVGSQGQAGPQAGR 60

Query: 61   DALLGFRDVPREPRRTRKPATRAPVLQVPPAGHEGLGAASGVPAVATMRKLFSFGRRLGQ 120
            DALLGFRDVPREPRRTRKPATRAPVLQVPPAGHEGLGAASGVPAVATMRKLFSFGRRLGQ
Sbjct: 61   DALLGFRDVPREPRRTRKPATRAPVLQVPPAGHEGLGAASGVPAVATMRKLFSFGRRLGQ 120

Query: 121  ALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLH 180
            ALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLH
Sbjct: 121  ALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLH 180

Query: 181  LACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIY 240
            LACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIY
Sbjct: 181  LACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIY 240

Query: 241  GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANI 300
            GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANI
Sbjct: 241  GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANI 300

Query: 301  HAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQIL 360
            HAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQIL
Sbjct: 301  HAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQIL 360

Query: 361  EHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQD 420
            EHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQD
Sbjct: 361  EHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQD 420

Query: 421  SQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSV 480
            SQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSV
Sbjct: 421  SQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSV 480

Query: 481  RLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEY 540
            RLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEY
Sbjct: 481  RLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEY 540

Query: 541  NEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRET 600
            NEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRET
Sbjct: 541  NEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRET 600

Query: 601  RDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELEN 660
            RDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELEN
Sbjct: 601  RDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELEN 660

Query: 661  LLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKE 720
            LLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKE
Sbjct: 661  LLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKE 720

Query: 721  KAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKH 780
            KAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKH
Sbjct: 721  KAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKH 780

Query: 781  EEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLN 840
            EEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLN
Sbjct: 781  EEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLN 840

Query: 841  TDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEK 900
            TDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEK
Sbjct: 841  TDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEK 900

Query: 901  DKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLE 960
            DKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLE
Sbjct: 901  DKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLE 960

Query: 961  QLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLM 1020
            QLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLM
Sbjct: 961  QLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLM 1020

Query: 1021 KSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLNSIELNRKYIPKTAIRIPT 1080
            KSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLNSIELNRKYIPKTAIRIPT
Sbjct: 1021 KSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLNSIELNRKYIPKTAIRIPT 1080

Query: 1081 SNPQTSNNCKNFLTEVLLCXALAPVYFLLXNPLHCLADLQLYTVPGFHLERVPALSALLG 1140
            SNPQTSNNCKNFLTEVLLC ALAPVYFLL NPLHCLADLQLYTVPGFHLERVPALSALLG
Sbjct: 1081 SNPQTSNNCKNFLTEVLLCXALAPVYFLLXNPLHCLADLQLYTVPGFHLERVPALSALLG 1140

Query: 1141 TPPLSASPGPPSVEREEIGEHLWEALILALGPGGDSDEDLGAPVSGAARPGQRSKTNKHT 1200
            TPPLSASPGPPSVEREEIGEHLWEALILALGPGGDSDEDLGAPVSGAARPGQRSKTNKHT
Sbjct: 1141 TPPLSASPGPPSVEREEIGEHLWEALILALGPGGDSDEDLGAPVSGAARPGQRSKTNKHT 1200

Query: 1201 HMYTHTRIHKHNACTHVSSGDRGHRLWALLTQAGSCCGGLCHPTMSLLLSPHRLCVVEQL 1260
            HMYTHTRIHKHNACTHVSSGDRGHRLWALLTQAGSCCGGLCHPTMSLLLSPHRLCVVEQL
Sbjct: 1201 HMYTHTRIHKHNACTHVSSGDRGHRLWALLTQAGSCCGGLCHPTMSLLLSPHRLCVVEQL 1260

Query: 1261 ETRSSLCEWLCMKDCFLGERHISTQLTDRTQQFHSASPLDTPRTXQDNPIMALSPGPVSL 1320
            ETRSSLCEWLCMKDCFLGERHISTQLTDRTQQFHSASPLDTPRT QDNPIMALSPGPVSL
Sbjct: 1261 ETRSSLCEWLCMKDCFLGERHISTQLTDRTQQFHSASPLDTPRTXQDNPIMALSPGPVSL 1320

Query: 1321 RDNQDAGPETTALLDAFNTVGELFANQPSQELDPVMDLLVLSLGHQVIILDIIHIHKEAL 1380
            RDNQDAGPETTALLDAFNTVGELFANQPSQELDPVMDLLVLSLGHQVIILDIIHIHKEAL
Sbjct: 1321 RDNQDAGPETTALLDAFNTVGELFANQPSQELDPVMDLLVLSLGHQVIILDIIHIHKEAL 1380

Query: 1381 TKVMESRQHVAEGKTEMQRLMTSESQEQDFFGHCG 1415
            TKVMESRQHVAEGKTEMQRLMTSESQEQDFFGHCG
Sbjct: 1381 TKVMESRQHVAEGKTEMQRLMTSESQEQDFFGHCG 1415


>gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
          Length = 1363

 Score = 2354 bits (6101), Expect = 0.0
 Identities = 1226/1424 (86%), Positives = 1273/1424 (89%), Gaps = 70/1424 (4%)

Query: 1    MSPWLRPSQAVYPAAAAPGQEPTPQSHPRWLRRAPVSGPDLSSEEERVGSQGQAGPQAGR 60
            MSPWLRPSQAV PAAAAPGQEPT    P      P SGPDLSSE+ R GS GQAG    R
Sbjct: 1    MSPWLRPSQAVCPAAAAPGQEPTLSPIPA---DGPWSGPDLSSEK-RGGSHGQAG----R 52

Query: 61   DALLGFRDVPREPRRTRKPATRAPVLQVPPAGHEGLGAASGVPAVATMRKLFSFGRRLGQ 120
            DA L F +VPR+PRRTRKPA   P LQ P AGH    A SGV AVATMRKL SFGRRLGQ
Sbjct: 53   DARLRFWNVPRQPRRTRKPAAPEPELQSPSAGHASSRAPSGVRAVATMRKLLSFGRRLGQ 112

Query: 121  ALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLH 180
            ALLSSMDQEYAG GY IRDWELRKIHRAAIKGDAAEVE CLTRRFRDLD RD+KDRTVLH
Sbjct: 113  ALLSSMDQEYAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLDVRDKKDRTVLH 172

Query: 181  LACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIY 240
            LACAHGRVQVVTLLL R+CQI+ICDRLNRTPLMKAVH QEEACAI+LL+ GANPNI+DIY
Sbjct: 173  LACAHGRVQVVTLLLDRKCQINICDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIY 232

Query: 241  GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANI 300
            GNTALHYAVYN+GTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANI
Sbjct: 233  GNTALHYAVYNEGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANI 292

Query: 301  HAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQIL 360
            HAVDNFKRTALILAVQHNLSSIVTLLLQQNI ISSQDMFGQTAEDYA C DLRSI+QQIL
Sbjct: 293  HAVDNFKRTALILAVQHNLSSIVTLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQIL 352

Query: 361  EHKNKMLKNHLRNDNQETAAMKPANLKKRKER---------AKAEHNLKVASEEKQERLQ 411
            EHKNKMLKNHLRNDNQETAAMKP NLKKRK+R         AKAEHNLKVASEEKQERL+
Sbjct: 353  EHKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLE 412

Query: 412  RSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITE 471
            RSENKQPQDSQSYGKKKD M+GNFMLK+DIAMLKEELYAIKNDSLRKEKKYIQEIKSITE
Sbjct: 413  RSENKQPQDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITE 472

Query: 472  INANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHS 531
            INANFEKSVRLNE+MITK VA+YSQQLNDLKAENARLNS+LEKEKHNKERLEAEVESLHS
Sbjct: 473  INANFEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHS 532

Query: 532  SLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFN 591
            +LATAINEYNEI+ERKDLELVLWRADDVSRHE MGSNISQLTDKNELLTEQVHKARVKFN
Sbjct: 533  NLATAINEYNEILERKDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFN 592

Query: 592  TLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEE 651
            TLKGKLRETRDALREKTLAL SVQLDL+QAQHRIKEMKQMHPNGEAKESQSIGKQNS EE
Sbjct: 593  TLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIGKQNSSEE 652

Query: 652  RIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLK 711
            RIRQ+ELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELM EYNYLK
Sbjct: 653  RIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMNEYNYLK 712

Query: 712  EKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQ 771
            EKLLQ EKEKAEREVIVREFQEELVDHLK FS+SESPLEGTSHCHINL+ETWTSKKKLFQ
Sbjct: 713  EKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEGTSHCHINLDETWTSKKKLFQ 772

Query: 772  VEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANE 831
            VEIQPEEKHEEFRK+FELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANE
Sbjct: 773  VEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANE 832

Query: 832  DFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNV 891
            DFSCHGDLNTDQLKMDILFKKLKQKF+DL+AEKEAVSS+CVNLAKDNEVLHQELLSM  V
Sbjct: 833  DFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKV 892

Query: 892  QEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQK 951
            QEKCEKLEKDKKMLEE+VLNLKTHMEKDMVELGK+QEYKSELDERA+Q IEKLEEIHLQK
Sbjct: 893  QEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQK 952

Query: 952  QAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKA 1011
            QAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYE+VTTELEE+KEAFA A+KA
Sbjct: 953  QAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEDVTTELEEYKEAFAVALKA 1012

Query: 1012 NNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLNSIELNRKYI 1071
            N+SMS+K+ KSDKKIAVISTKLF EK+RM+YFLSTLP RP+PELPCVENLNSIELNRKYI
Sbjct: 1013 NSSMSEKITKSDKKIAVISTKLFMEKERMEYFLSTLPMRPDPELPCVENLNSIELNRKYI 1072

Query: 1072 PKTAIRIPTSNPQTSNNCKNFLTEVLLCXALAPVYFLLXNPLHCLADLQLYTVPGFHLER 1131
            PK AIRIPTSNPQTSNNCKN LTE+LL  ALAP+YFLL NPLHCL DLQLYT PGFHLER
Sbjct: 1073 PKMAIRIPTSNPQTSNNCKNSLTELLLRWALAPIYFLLXNPLHCLGDLQLYTRPGFHLER 1132

Query: 1132 VPALSALLGTPPLSASPGPPSVEREEIGEHLWEALILALGPGGDSDEDLGAPVSGAARPG 1191
            VPALSALLG PPLSAS GPP VER EIGEHLWEALILALGPGGDSDEDLG+   G   P 
Sbjct: 1133 VPALSALLGAPPLSASLGPPLVERAEIGEHLWEALILALGPGGDSDEDLGSCCGGLCHP- 1191

Query: 1192 QRSKTNKHTHMYTHTRIHKHNACTHVSSGDRGHRLWALLTQAGSCCGGLCHPTMSLLLSP 1251
                                                                TMSLLLSP
Sbjct: 1192 ----------------------------------------------------TMSLLLSP 1199

Query: 1252 HRLCVVEQLETRSSLCEWLCMKDCFLGERHISTQLTDRTQQFHSASPLDTPRTXQDNPIM 1311
            HRLCV+EQLET SSLCEWLC+KDCFLGE HISTQLT +TQQFHSASPLDTPRT QDNPIM
Sbjct: 1200 HRLCVLEQLETHSSLCEWLCVKDCFLGEMHISTQLTAQTQQFHSASPLDTPRTXQDNPIM 1259

Query: 1312 ALSPGPVSLRDNQDAGPETTALLDAFNTVGELFANQPSQELDPVMDLLVLSLGHQVIILD 1371
            ALSPGPV L DNQ AGPETTALLDAFNTVGEL ANQP QELDPVMDLLVLS GHQV I D
Sbjct: 1260 ALSPGPVWLHDNQHAGPETTALLDAFNTVGELXANQPIQELDPVMDLLVLSQGHQVNIPD 1319

Query: 1372 IIHIHKEALTKVMESRQHVAEGKTEMQRLMTSESQEQDFFGHCG 1415
            IIHIHKEALTKVMESRQHVAEGKTE+QRLM SESQEQDFFGHCG
Sbjct: 1320 IIHIHKEALTKVMESRQHVAEGKTEVQRLMMSESQEQDFFGHCG 1363


>gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
          Length = 1366

 Score = 2274 bits (5893), Expect = 0.0
 Identities = 1202/1453 (82%), Positives = 1250/1453 (86%), Gaps = 125/1453 (8%)

Query: 1    MSPWLRPSQAVYPAAAAPGQEPTPQSHPRWLRRAPVSGPDLSSEEERVGSQGQAGPQAGR 60
            MSPWLRPSQAV PAAAAPGQEPT    P      P SGPDLSSE+ R GS GQAG    R
Sbjct: 1    MSPWLRPSQAVCPAAAAPGQEPTLSPIPA---DGPWSGPDLSSEK-RGGSHGQAG----R 52

Query: 61   DALLGFRDVPREPRRTRKPATRAPVLQVPPAGHEGLGAASGVPA---------------- 104
            DA L FR+VPR+PRRTRKPA   P LQ P AGH    A SGV A                
Sbjct: 53   DARLRFRNVPRQPRRTRKPAAPEPELQSPSAGHASSRAPSGVRAGAELGRRLRVSLLKAV 112

Query: 105  -------------VATMRKLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIK 151
                         VATMRKL SFGRRLGQALLSSMDQEYAG GY IRDWELRKIHRAAIK
Sbjct: 113  VDRAGSRILSYIAVATMRKLLSFGRRLGQALLSSMDQEYAGRGYHIRDWELRKIHRAAIK 172

Query: 152  GDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTP 211
            GDAAEVE CLTRRFRDLD RD+KDRTVLHLACAHGRVQVVTLLL R+CQI+ICDRLNRTP
Sbjct: 173  GDAAEVEHCLTRRFRDLDVRDKKDRTVLHLACAHGRVQVVTLLLDRKCQINICDRLNRTP 232

Query: 212  LMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALN 271
            LMKAVH QEEACAI+LL+ GANPNI+DIYGNTALHYAVYN+GTSLAERLLSHHANIEALN
Sbjct: 233  LMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSHHANIEALN 292

Query: 272  KEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNI 331
            KEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNI
Sbjct: 293  KEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNI 352

Query: 332  RISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKE 391
             ISSQDMFGQTAEDYA C DLRSI+QQILEHKNKMLKNHLRNDNQETAAMKP NLKKRK+
Sbjct: 353  HISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKPENLKKRKK 412

Query: 392  R---------AKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIA 442
            R         AKAEHNLKVASEEKQERL+RSENKQPQDSQSYGKKKD M+GNFMLK+DIA
Sbjct: 413  RKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIA 472

Query: 443  MLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLK 502
            MLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNE+MITK VA+YSQQLNDLK
Sbjct: 473  MLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLK 532

Query: 503  AENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRH 562
            AENARLNS+LEKEKHNKERLEAEVESLHS+LATAINEYNEI+ERKDLELVLWRADDVSRH
Sbjct: 533  AENARLNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERKDLELVLWRADDVSRH 592

Query: 563  EKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQ 622
            E MGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLAL SVQLDL+QAQ
Sbjct: 593  ETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQ 652

Query: 623  HRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVIN 682
            HRIKEMKQMHPNGEAKESQSIGKQNS EERIRQ+ELENLLLERQLEDARKEGDNKEIVIN
Sbjct: 653  HRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVIN 712

Query: 683  IHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTF 742
            IHRDCLENGKEDLLEERNKELM EYNYLKEKLLQ EKEKAEREVIVREFQEELVDHLK F
Sbjct: 713  IHRDCLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKF 772

Query: 743  SISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRK 802
            S+SESPLEGTSHCHINL+ETWTSKKKLFQVEIQPEEKHEEFRK+FELISLLNYTADQIRK
Sbjct: 773  SMSESPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRK 832

Query: 803  KNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVA 862
            KNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKF+DL+A
Sbjct: 833  KNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMA 892

Query: 863  EKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVE 922
            EKEAVSS+CVNLAKDNEVLHQELLSM  VQEKCEKLEKDKKMLEE+VLNLKTHMEKDMVE
Sbjct: 893  EKEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVE 952

Query: 923  LGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVEC 982
            LGK+QEYKSELDERA+Q IEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVEC
Sbjct: 953  LGKVQEYKSELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVEC 1012

Query: 983  KFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKY 1042
            KFSKMKTAYE+VTTELEE+KEAFA A+KAN+SMS+K+ KSDKKIAVISTKLF EK+RM+Y
Sbjct: 1013 KFSKMKTAYEDVTTELEEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKERMEY 1072

Query: 1043 FLSTLPTRPEPELPCVENLNSIELNRKYIPKTAIRIPTSNPQTSNNCKNFLTEVLLCXAL 1102
            FLSTLP RP+PELPCVENLNSIELNRKYIPK AIRIPTSNPQTSNNCKN LTE+LL  AL
Sbjct: 1073 FLSTLPMRPDPELPCVENLNSIELNRKYIPKMAIRIPTSNPQTSNNCKNSLTELLLRWAL 1132

Query: 1103 APVYFLLXNPLHCLADLQLYTVPGFHLERVPALSALLGTPPLSASPGPPSVEREEIGEHL 1162
            AP+YFLL NP                         L+G P   A  GPPSVEREEIGEHL
Sbjct: 1133 APIYFLLXNP-------------------------LMG-PEGLAGEGPPSVEREEIGEHL 1166

Query: 1163 WEALILALGPGGDSDEDLGAPVSGAARPGQRSKTNKHTHMYTHTRIHKHNACTHVSSGDR 1222
            WEALILALGPGGDSDEDLG+   G   P                                
Sbjct: 1167 WEALILALGPGGDSDEDLGSCCGGLCHP-------------------------------- 1194

Query: 1223 GHRLWALLTQAGSCCGGLCHPTMSLLLSPHRLCVVEQLETRSSLCEWLCMKDCFLGERHI 1282
                                 TMSLLLSPHRLCV+EQLET SSLCEWLC+KDCFLGE HI
Sbjct: 1195 ---------------------TMSLLLSPHRLCVLEQLETHSSLCEWLCVKDCFLGEMHI 1233

Query: 1283 STQLTDRTQQFHSASPLDTPRTXQDNPIMALSPGPVSLRDNQDAGPETTALLDAFNTVGE 1342
            STQLT +TQQFHSASPLDTPRT QDNPIMALSPGPV L DNQDAGPETTALLDAFNTVGE
Sbjct: 1234 STQLTAQTQQFHSASPLDTPRTXQDNPIMALSPGPVWLHDNQDAGPETTALLDAFNTVGE 1293

Query: 1343 LFANQPSQELDPVMDLLVLSLGHQVIILDIIHIHKEALTKVMESRQHVAEGKTEMQRLMT 1402
            L ANQP QELDPVMDLLVLS GHQV I DIIHIHKEALTKVMESRQHVAEGKTE+QRLM 
Sbjct: 1294 LXANQPIQELDPVMDLLVLSQGHQVNIPDIIHIHKEALTKVMESRQHVAEGKTEVQRLMM 1353

Query: 1403 SESQEQDFFGHCG 1415
            SESQEQDFFGHCG
Sbjct: 1354 SESQEQDFFGHCG 1366


>gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
          Length = 1002

 Score = 1942 bits (5032), Expect = 0.0
 Identities = 991/1002 (98%), Positives = 996/1002 (99%)

Query: 108  MRKLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRD 167
            MRKLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRD
Sbjct: 1    MRKLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRD 60

Query: 168  LDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVL 227
            LDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVL
Sbjct: 61   LDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVL 120

Query: 228  LECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQ 287
            LECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQ
Sbjct: 121  LECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQ 180

Query: 288  HMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYA 347
            HMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYA
Sbjct: 181  HMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYA 240

Query: 348  LCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQ 407
            LCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQ
Sbjct: 241  LCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQ 300

Query: 408  ERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIK 467
            ERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIK
Sbjct: 301  ERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIK 360

Query: 468  SITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVE 527
            SITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVE
Sbjct: 361  SITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVE 420

Query: 528  SLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKAR 587
            SLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKAR
Sbjct: 421  SLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKAR 480

Query: 588  VKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQN 647
            VKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQN
Sbjct: 481  VKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQN 540

Query: 648  SLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEY 707
            SLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEY
Sbjct: 541  SLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEY 600

Query: 708  NYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKK 767
            NYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKK
Sbjct: 601  NYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKK 660

Query: 768  KLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNA 827
            KLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNA
Sbjct: 661  KLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNA 720

Query: 828  FANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLS 887
            FANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLS
Sbjct: 721  FANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLS 780

Query: 888  MRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEI 947
            MRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEI
Sbjct: 781  MRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEI 840

Query: 948  HLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAG 1007
            HLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAG
Sbjct: 841  HLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAG 900

Query: 1008 AVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLNSIELN 1067
            AVKANNSMSKKLMKSDKKIAVISTKLF EK+RM+YFLSTLP RP+PELPCVENLNSIELN
Sbjct: 901  AVKANNSMSKKLMKSDKKIAVISTKLFMEKERMEYFLSTLPMRPDPELPCVENLNSIELN 960

Query: 1068 RKYIPKTAIRIPTSNPQTSNNCKNFLTEVLLCXALAPVYFLL 1109
            RKYIPK AIRIPTSNPQTSNNCKN LTE+LL  ALAP+YFLL
Sbjct: 961  RKYIPKMAIRIPTSNPQTSNNCKNSLTELLLRWALAPIYFLL 1002


>gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
          Length = 1139

 Score = 1926 bits (4990), Expect = 0.0
 Identities = 1004/1147 (87%), Positives = 1045/1147 (91%), Gaps = 46/1147 (4%)

Query: 1    MSPWLRPSQAVYPAAAAPGQEPTPQSHPRWLRRAPVSGPDLSSEEERVGSQGQAGPQAGR 60
            MSPWLRPSQAV PAAAAPGQEPT    P      P SGPDLSSE+ R GS GQAG    R
Sbjct: 1    MSPWLRPSQAVCPAAAAPGQEPTLSPIPA---DGPWSGPDLSSEK-RGGSHGQAG----R 52

Query: 61   DALLGFRDVPREPRRTRKPATRAPVLQVPPAGHEGLGAASGVPA---------------- 104
            DA L FR+VPR+PRRTRKPA   P LQ P AGH    A SGV A                
Sbjct: 53   DARLRFRNVPRQPRRTRKPAAPEPELQSPSAGHASSRAPSGVRAGAELGRRLRVSLLKAV 112

Query: 105  -------------VATMRKLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIK 151
                         VATMRKL SFGRRLGQALLSSMDQEYAG GY IRDWELRKIHRAAIK
Sbjct: 113  VDRAGSRILSYIAVATMRKLLSFGRRLGQALLSSMDQEYAGRGYHIRDWELRKIHRAAIK 172

Query: 152  GDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTP 211
            GDAAEVE CLTRRFRDLD RDRKDRTVLHLACAHGRVQVVTLLL R+CQI+ICDRLNRTP
Sbjct: 173  GDAAEVEHCLTRRFRDLDVRDRKDRTVLHLACAHGRVQVVTLLLDRKCQINICDRLNRTP 232

Query: 212  LMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALN 271
            LMKAVH QEEACAI+LL+ GANPNI+DIYGNTALHYAVYN+GTSLAERLLSHHANIEALN
Sbjct: 233  LMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSHHANIEALN 292

Query: 272  KEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNI 331
            KEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNI
Sbjct: 293  KEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNI 352

Query: 332  RISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKE 391
             ISSQDMFGQTAEDYA C DLRSI+QQILEHKNKMLKNHLRNDNQETAAMKP NLKKRK+
Sbjct: 353  HISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKPENLKKRKK 412

Query: 392  R---------AKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIA 442
            R         AKAEHNLKVASEEKQERL+RSENKQPQDSQSYGKKKD M+GNFMLK+DIA
Sbjct: 413  RKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIA 472

Query: 443  MLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLK 502
            MLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNE+MITK VA+YSQQLNDLK
Sbjct: 473  MLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLK 532

Query: 503  AENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRH 562
            AENARLNS+LEKEKHNKERLEAEVESLHS+LATAINEYNEI+ERKDLELVLWRADDVSRH
Sbjct: 533  AENARLNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERKDLELVLWRADDVSRH 592

Query: 563  EKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQ 622
            E MGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLAL SVQLDL+QAQ
Sbjct: 593  ETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQ 652

Query: 623  HRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVIN 682
            HRIKEMKQMHPNGEAKESQSIGKQNS EERIRQ+ELENLLLERQLEDARKEGDNKEIVIN
Sbjct: 653  HRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVIN 712

Query: 683  IHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTF 742
            IHRDCLENGKEDLLEERNKELM EYNYLKEKLLQ EKEKAEREVIVREFQEELVDHLK F
Sbjct: 713  IHRDCLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKF 772

Query: 743  SISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRK 802
            S+SESPLEGTSHCHINL+ETWTSKKKLFQVEIQPEEKHEEFRK+FELISLLNYTADQIRK
Sbjct: 773  SMSESPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRK 832

Query: 803  KNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVA 862
            KNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKF+DL+A
Sbjct: 833  KNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMA 892

Query: 863  EKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVE 922
            EKEAVSS+CVNLAKDNEVLHQELLSM  VQEKCEKLEKDKKMLEE+VLNLKTHMEKDMVE
Sbjct: 893  EKEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVE 952

Query: 923  LGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVEC 982
            LGK+QEYKSELDERA+Q IEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVEC
Sbjct: 953  LGKVQEYKSELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVEC 1012

Query: 983  KFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKY 1042
            KFSKMKTAYE+VTTELEE+KEAFA A+KAN+SMS+K+ KSDKKIAVISTKLF EK+RM+Y
Sbjct: 1013 KFSKMKTAYEDVTTELEEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKERMEY 1072

Query: 1043 FLSTLPTRPEPELPCVENLNSIELNRKYIPKTAIRIPTSNPQTSNNCKNFLTEVLLCXAL 1102
            FLSTLP RP+PELPCVENLNSIELNRKYIPK AIRIPTSNPQTSNNCKN LTE+LL  AL
Sbjct: 1073 FLSTLPMRPDPELPCVENLNSIELNRKYIPKMAIRIPTSNPQTSNNCKNSLTELLLRWAL 1132

Query: 1103 APVYFLL 1109
            AP+YFLL
Sbjct: 1133 APIYFLL 1139


>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
          Length = 1710

 Score =  527 bits (1357), Expect = e-149
 Identities = 335/821 (40%), Positives = 498/821 (60%), Gaps = 88/821 (10%)

Query: 358  QILEHKNKMLKNHL------RNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQ 411
            Q LE + + +K++L      RND Q   + +  N +  ++     H  K    E  ++  
Sbjct: 838  QTLEMELRTVKSNLNQVVQERNDAQRQLS-REQNARMLQDGILTNHLSKQKEIEMAQKKM 896

Query: 412  RSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITE 471
             SEN     S S+ ++KD  + N ML+++IAML+ E+  IKN +  KEKK  +++K + E
Sbjct: 897  NSEN-----SHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKE 951

Query: 472  INANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHS 531
             N + +K+++ NE+ +T+T+++Y+ +L+ L AENA LNS+LE EK +KERLEAEVES HS
Sbjct: 952  KNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHS 1011

Query: 532  SLATAINEYNEI-VERKDLELVLWRA-DDVSR-HEKMGSNISQLTDKNELLTEQVHKARV 588
             LA AI++ ++    +++LEL   RA D+ SR  +KM  ++S L D NE+L++Q+ K   
Sbjct: 1012 RLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTES 1071

Query: 589  KFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNS 648
            K N+L+ +   TRDALREKTL L  VQ DL Q Q ++KEM+Q + N + K ++ IGKQ S
Sbjct: 1072 KLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQES 1131

Query: 649  LEERIRQQELENLLLERQLEDARKEGDNKE-IVINIHRDC--------LENGKEDLL-EE 698
            +EER+ Q + EN+LL +QL+DA  + DNKE  VINI             E+ K+ LL EE
Sbjct: 1132 VEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEE 1191

Query: 699  RNKELMKEYNYLKEKLLQCEKE-------------------------KAEREVIVR---E 730
            RNKEL+ E N+LKE+  Q E E                         +A  EV  R    
Sbjct: 1192 RNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRIN 1251

Query: 731  FQEELVDHLKTFSISESPLEGTSHCHI-------------------NLNETWTSKKKLFQ 771
             ++E  D  K      + L+     H                    N     T KK++ +
Sbjct: 1252 LEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDK 1311

Query: 772  VE-IQP--------EEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTI 822
            +E +Q         E++ E+ +KL EL   L    DQ  KKN ELE E TG+K  L+MT 
Sbjct: 1312 IEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTR 1371

Query: 823  NMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLH 882
              LN + N +FS HGDL T Q +MDI   KLK K +DL AE E   S+C++L   N++L 
Sbjct: 1372 KKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQ 1431

Query: 883  QELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEI- 941
            +ELLSM+ VQ+KCEKL+K+KK LE+EV+NL++H+E++MVELG++++YK E++ERA QEI 
Sbjct: 1432 EELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIA 1491

Query: 942  EKLEEIH--LQKQAEYEKQLEQLNKDNTASLKKK-ELTLKDVECKFSKMKTAYEEVT-TE 997
            EKL+E++  LQ QA  ++ LEQ  ++N AS+K + EL +KD+E + SK+KT+ E+   TE
Sbjct: 1492 EKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTE 1551

Query: 998  LEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPC 1057
            LE++K+ +   +K   S+S KL K+++++A ++TKL  EKQ+ +   +TL TRP  E PC
Sbjct: 1552 LEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPC 1611

Query: 1058 VENL-NSIELNRKYIPKTAIRIPTSNPQTSNN-CKNFLTEV 1096
            V NL NS++LNRK IP+  + I TSNP+ SNN  +N+L+++
Sbjct: 1612 VGNLNNSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKM 1652



 Score =  207 bits (527), Expect = 6e-53
 Identities = 99/185 (53%), Positives = 140/185 (75%)

Query: 130 YAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQ 189
           Y+ PGY +RD +L KIH+AA  G+ A+V++ L  R   L+ RD+ +RT LHLACA+G  +
Sbjct: 35  YSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPE 94

Query: 190 VVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAV 249
           VVTLL+ R+CQ+++CD  NRT LMKAV  QEE CA +LLE GA+PN+ D++GNTALHYAV
Sbjct: 95  VVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAV 154

Query: 250 YNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRT 309
           YN+  S+A +LL + ANIEA NK+  TPLL A++ ++Q MVEFL+K +AN++AVD  + +
Sbjct: 155 YNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESS 214

Query: 310 ALILA 314
             +++
Sbjct: 215 HQLIS 219



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 150/743 (20%), Positives = 305/743 (41%), Gaps = 94/743 (12%)

Query: 338  MFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRN--DNQETAAMKPANLKKRKERAKA 395
            M G      A   D R++   +   ++     HL+   + +++   K   +K  +    A
Sbjct: 463  MSGSRNFKMAKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAA 522

Query: 396  EHNLKVASEEKQERLQRSENKQPQDSQSYGKKK-----------DAMYGNFMLKKDIAML 444
            EH+L+VASEE+QER + SEN QPQ  +   K +           D    +     D   L
Sbjct: 523  EHDLEVASEEEQER-EGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGL 581

Query: 445  KEELYAIKNDSL---RKEKK---------YIQEIKSITEINANFEKSVRL----NEKMIT 488
             ++  + + D     RKE K          ++E+KS  +     ++SV         ++T
Sbjct: 582  IQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLT 641

Query: 489  KTVARYSQQ--LNDLKAENARLNSELEKEKHN-KERLEA--EVESLHSSLATAINE---- 539
              + +      L+++  +  R   +   EK+  K ++++  +V+ L  S  TA  +    
Sbjct: 642  GGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELP 701

Query: 540  ------YNEIVERKDLELVLWRADDVSRHEKMGSNIS--QLTD--KN--ELLTEQVHKAR 587
                  +  ++E+  +E      D VS  +   + +S  +L +  KN  ELLT ++ K  
Sbjct: 702  HSSYKNFMLLIEQLGMEC----KDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKME 757

Query: 588  VKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQN 647
             K N L+ +L ET++   +        + +L   +  + + ++   N +    +   +  
Sbjct: 758  DKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLR 817

Query: 648  SLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKE- 706
              EE+ R++      LE  L+    E    +  +N       + +  L  E+N  ++++ 
Sbjct: 818  RKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDG 877

Query: 707  --YNYL-KEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETW 763
               N+L K+K ++  ++K   E      +E+ + H K   + E             N+  
Sbjct: 878  ILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSH-KNSMLQEEIAMLRLEIDTIKNQNQ 936

Query: 764  TSKKKLFQVEIQPEEKHEEFRK--------LFELISLLNYTADQIRKKNRELE---EEAT 812
              +KK F+     +EK+E+ +K        L + IS  N     +  +N  L    E   
Sbjct: 937  EKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEK 996

Query: 813  GYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECV 872
              K+ LE  +   ++             T + ++++ F++ + + + L   ++ ++ +  
Sbjct: 997  QSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRL---QDKMNFDVS 1053

Query: 873  NLAKDNEVLHQELLSMRNVQEKCE-KLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKS 931
            NL  +NE+L Q+L    +     E +    +  L E+ L L    E+   +L + Q    
Sbjct: 1054 NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGL----ERVQKDLSQTQCQMK 1109

Query: 932  ELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTA----------SLKKKELTLKDVE 981
            E++++   E  K+ + ++ KQ   E++L QL  +N                KE T+ +++
Sbjct: 1110 EMEQKYQNEQVKVNK-YIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQ 1168

Query: 982  CKF----SKMKTAYEEVTTELEE 1000
             +F     K++   E+ +  LEE
Sbjct: 1169 DQFHAIVQKLQAESEKQSLLLEE 1191



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 113/576 (19%), Positives = 226/576 (39%), Gaps = 75/576 (13%)

Query: 246  HYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFL--LKNQANIHAV 303
            H    NK  ++       HA ++ L  E     L  +  R + ++     LK +   +  
Sbjct: 1154 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL-LEERNKELISECNHLKERQYQYEN 1212

Query: 304  DNFKRTALILAVQHNLSSIVTL--LLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILE 361
            +  +R  ++  +Q  L+  +    + + ++ ++S+       E   L   L  IR Q+ E
Sbjct: 1213 EKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQE 1272

Query: 362  HKNKML------------KNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQER 409
             +++              K  L  DN +        + K +E  K   N  ++ +EK++ 
Sbjct: 1273 AQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQL 1332

Query: 410  LQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIK---NDSLRKEKKYIQEI 466
             +  E KQ  +     + K     N  L+++I   K  L   +   N+    E  +  ++
Sbjct: 1333 KKLMELKQSLECNLDQEMKK----NVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDL 1388

Query: 467  KSITEINANFEKSVRLNEKM-----ITKTVARYSQQLNDLKAENARLNSEL--------- 512
            K+     + FE  +++N+       +T  +     +   L  +N  L  EL         
Sbjct: 1389 KT-----SQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKK 1443

Query: 513  -EKEKHNKERLEAEVESLHSSLAT------AINEYNEIVERKDLELVLWRADDVS----R 561
             EK + NK++LE EV +L S +         + +Y + +E +  + +  +  +V+     
Sbjct: 1444 CEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQA 1503

Query: 562  HEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALRE--KTLALGSVQLDLR 619
                  N+ Q  + N    +   + R+K   L+ +L + + +  +  KT      QL L 
Sbjct: 1504 QAASQENLEQFRENNFASMKSQMELRIK--DLESELSKIKTSQEDFNKTELEKYKQLYLE 1561

Query: 620  QAQHRIKEMKQMHPNGEAKESQSIGKQNS--LEERIRQQELENLLLERQLEDARKEGD-N 676
            + + R     ++      K ++ + + N+  L E+ + + L   L  R + +    G+ N
Sbjct: 1562 ELKVRKSLSSKL-----TKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLN 1616

Query: 677  KEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELV 736
              + +N      EN        R      E NYL +   + EK       I RE +E   
Sbjct: 1617 NSLDLNRKLIPRENLVISTSNPRASNNSME-NYLSKMQQELEKN------ITRELKEAAA 1669

Query: 737  DHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQV 772
            + L++ SI+ SPL  T   ++N +  W + ++  QV
Sbjct: 1670 E-LESGSIA-SPLGSTDESNLNQDLVWKASREYVQV 1703



 Score = 34.3 bits (77), Expect = 0.87
 Identities = 37/179 (20%), Positives = 75/179 (41%), Gaps = 15/179 (8%)

Query: 858  NDLVAEKEAVSSECV--NLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLK-T 914
            +DL    E  S +C   + +  N +L  E L M           +D  +  E +L LK  
Sbjct: 685  DDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKN 744

Query: 915  HMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKE 974
            H E   V++ K+++ K  + +R + E ++++     ++ E+E++L  L            
Sbjct: 745  HCELLTVKIKKMED-KVNVLQRELSETKEIKSQLEHQKVEWERELCSLR----------- 792

Query: 975  LTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKL 1033
             +L   E K     T YE++  +L   +E +   V+    +   L   + ++  + + L
Sbjct: 793  FSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNL 851


>gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo
           sapiens]
          Length = 823

 Score =  369 bits (948), Expect = e-102
 Identities = 289/910 (31%), Positives = 439/910 (48%), Gaps = 132/910 (14%)

Query: 110 KLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLD 169
           KLF FG R GQ    S+D  Y G GY IRD EL+KIHRAA+KGDAAEVERCL RR  DLD
Sbjct: 2   KLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLD 61

Query: 170 ARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLE 229
           A D++ RT LHLACA G VQVVTLL++R+CQID+CD+ NRTPL++AVH QEEACA++LLE
Sbjct: 62  ALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLE 121

Query: 230 CGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 289
            GANPN++DIYGNTALHYAVY++ TSLAE+LLSH A+IEAL+K+ NTPLLFAI  +++ M
Sbjct: 122 HGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKM 181

Query: 290 VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALC 349
           VEFLLK +A+ HAVD  +R+AL+LAV ++   IV +LL+QNI + +QDM G+ AEDYA+ 
Sbjct: 182 VEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAIS 241

Query: 350 SDLRSIRQQILEHKNKMLK-----------------NHLRNDNQETAAMKPANL-KKRKE 391
             L  I+QQILEHK K+LK                 + LR D+   +  K  N+  K+  
Sbjct: 242 HHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCV 301

Query: 392 RAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKK----KDAMYGNFMLKKDIAMLKEE 447
             K    L  +S EK  R+   + + P       K     +D      + +K++  L+ E
Sbjct: 302 PEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAE 361

Query: 448 LYAIKNDSLRKEKKYIQEIKSITEI----NANFEKSVRLNEKMITKT----VARYSQQLN 499
             A+   S  +++++ +  K   ++    N N  + ++L+E +   T      R +QQ  
Sbjct: 362 -QALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420

Query: 500 DLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDV 559
             K    +   +L KE+H++  L+ E E   +++     +  E +ERK+           
Sbjct: 421 IGKTYPQQFPKKL-KEEHDRCTLKQENEE-KTNVNMLYKKNREELERKE----------- 467

Query: 560 SRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLR 619
            +  K      QL    + L  +   AR   N       E +  + E  +    ++ D+ 
Sbjct: 468 -KQYKKEVEAKQLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCI----LKADIA 522

Query: 620 QAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEI 679
             +  I  MK          + ++ K+N   + I+  +  N  LE            K I
Sbjct: 523 ILRQEICTMK----------NDNLEKENKYLKDIKIVKETNAALE------------KYI 560

Query: 680 VINIHRDCLENGKEDLLEERNKELMKEYNYLK-------EKLLQCEKEKAEREVIVREFQ 732
            +N          E+++ E      +E NYLK        +LL+ ++ K   E  +  +Q
Sbjct: 561 KLN----------EEMITETAFRYQQELNYLKAENTRLNAELLKEKESKKRLEADIESYQ 610

Query: 733 EELV-------DHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRK 785
             L        + +KT    +  LE T    + +  +    K   + E   E+  E   K
Sbjct: 611 SRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIK 670

Query: 786 LFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLK 845
              L      T D +RKK+  LE       +  + T  M   + N +             
Sbjct: 671 FNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAE------------- 717

Query: 846 MDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKML 905
                     K N+   +   V     +L ++N  L Q+L               D    
Sbjct: 718 ---------AKVNNSTGKWNCVEERICHLQRENAWLVQQL---------------DDVHQ 753

Query: 906 EEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKD 965
           +E+   + T++++  +E GK      E  ++ + E + L+E   Q + E  + +  + +D
Sbjct: 754 KEDHKEIVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQYEREKTEGVVSIKED 813

Query: 966 NTASLKKKEL 975
                 +K +
Sbjct: 814 KYFQTSRKTI 823



 Score = 32.3 bits (72), Expect = 3.3
 Identities = 50/238 (21%), Positives = 97/238 (40%), Gaps = 46/238 (19%)

Query: 851  KKLKQKFNDLVAEKEAVSSECVNLA--KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEE 908
            KKLK++ +    ++E      VN+   K+ E L ++        EK  K E + K LE  
Sbjct: 431  KKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERK--------EKQYKKEVEAKQLEPT 482

Query: 909  VLNL----KTHMEKDMVELGKLQEYKSELDERAV---------QEIEKLEEIHLQKQAEY 955
            V +L    KT       +    +E K  +DE  +         QEI  ++  +L+K+ +Y
Sbjct: 483  VQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKY 542

Query: 956  EKQLEQLNKDNTASLK----------------KKELTLKDVE-----CKFSKMKTAYEEV 994
             K ++ + + N A  K                ++EL     E      +  K K + + +
Sbjct: 543  LKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNYLKAENTRLNAELLKEKESKKRL 602

Query: 995  TTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPE 1052
              ++E ++   A A+  ++   K   + + K+A+  T+  + +  M   +S +    E
Sbjct: 603  EADIESYQSRLAAAISKHSESVK--TERNLKLALERTRDVSVQVEMSSAISKVKDENE 658


>gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo
           sapiens]
          Length = 823

 Score =  369 bits (947), Expect = e-101
 Identities = 290/904 (32%), Positives = 437/904 (48%), Gaps = 120/904 (13%)

Query: 110 KLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLD 169
           KLF FG R GQ    S+D  Y G GY IRD EL+KIHRAA+KGDAAEVERCL RR  DLD
Sbjct: 2   KLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLD 61

Query: 170 ARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLE 229
           A D++ RT LHLACA G VQVVTLL++R+CQID+CD+ NRTPL++AVH QEEACA++LLE
Sbjct: 62  ALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLE 121

Query: 230 CGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 289
            GANPN++DIYGNTALHYAVY++ TSLAE+LLSH A+IEAL+K+ NTPLLFAI  +++ M
Sbjct: 122 HGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKM 181

Query: 290 VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALC 349
           VEFLLK +A+ HAVD  +R+AL+LAV ++   IV +LL+QNI + +QDM G+ AEDYA+ 
Sbjct: 182 VEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAIS 241

Query: 350 SDLRSIRQQILEHKNKMLK-----------------NHLRNDNQETAAMKPANL-KKRKE 391
             L  I+QQILEHK K+LK                 + LR D+   +  K  N+  K+  
Sbjct: 242 HHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCV 301

Query: 392 RAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKK----KDAMYGNFMLKKDIAMLKEE 447
             K    L  +S EK  R+   + + P       K     +D      + +K++  L+ E
Sbjct: 302 PEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAE 361

Query: 448 LYAIKNDSLRKEKKYIQEIKSITEI----NANFEKSVRLNEKMITKT----VARYSQQLN 499
             A+   S  +++++ +  K   ++    N N  + ++L+E +   T      R +QQ  
Sbjct: 362 -QALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420

Query: 500 DLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDV 559
             K    +   +L KE+H++  L+ E E                                
Sbjct: 421 IGKTYPQQFPKKL-KEEHDRCTLKQENE-------------------------------- 447

Query: 560 SRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLR 619
              EK  +N++ L  KN    E+  K   K    K +L  T  +L  K+    +      
Sbjct: 448 ---EK--TNVNMLYKKNREELERKEKQYKKEVEAK-QLEPTVQSLEMKSKTARNTP---N 498

Query: 620 QAQHRIKEMK-QMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKE 678
           +  H  +EMK  M  N   K   +I +Q     +    E EN  L + ++  ++     E
Sbjct: 499 RDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYL-KDIKIVKETNAALE 557

Query: 679 IVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELV-- 736
             I ++ + +        +E N +L  E   L  +LL+ ++ K   E  +  +Q  L   
Sbjct: 558 KYIKLNEEMITETAFRYQQELN-DLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAA 616

Query: 737 -----DHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELIS 791
                + +KT    +  LE T    + +  +    K   + E   E+  E   K   L  
Sbjct: 617 ISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKD 676

Query: 792 LLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFK 851
               T D +RKK+  LE       +  + T  M   + N +                   
Sbjct: 677 KFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAE------------------- 717

Query: 852 KLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLN 911
               K N+   +   V     +L ++N  L Q+L               D    +E+   
Sbjct: 718 ---AKVNNSTGKWNCVEERICHLQRENAWLVQQL---------------DDVHQKEDHKE 759

Query: 912 LKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLK 971
           + T++++  +E GK      E  ++ + E + L+E   Q + E  + +  + +D      
Sbjct: 760 IVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTS 819

Query: 972 KKEL 975
           +K++
Sbjct: 820 RKKI 823



 Score = 32.7 bits (73), Expect = 2.5
 Identities = 49/238 (20%), Positives = 100/238 (42%), Gaps = 46/238 (19%)

Query: 851  KKLKQKFNDLVAEKEAVSSECVNLA--KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEE 908
            KKLK++ +    ++E      VN+   K+ E L ++        EK  K E + K LE  
Sbjct: 431  KKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERK--------EKQYKKEVEAKQLEPT 482

Query: 909  VLNL----KTHMEKDMVELGKLQEYKSELDERAV---------QEIEKLEEIHLQKQAEY 955
            V +L    KT       +    +E K  +DE  +         QEI  ++  +L+K+ +Y
Sbjct: 483  VQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKY 542

Query: 956  EKQLEQLNKDNTASLKKKELT--------------LKDVECKFSKM-------KTAYEEV 994
             K ++ + + N A  K  +L               L D++ + +++       K + + +
Sbjct: 543  LKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRL 602

Query: 995  TTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPE 1052
              ++E ++   A A+  ++   K   + + K+A+  T+  + +  M   +S +    E
Sbjct: 603  EADIESYQSRLAAAISKHSESVK--TERNLKLALERTRDVSVQVEMSSAISKVKDENE 658


>gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo
           sapiens]
          Length = 823

 Score =  368 bits (945), Expect = e-101
 Identities = 291/904 (32%), Positives = 435/904 (48%), Gaps = 120/904 (13%)

Query: 110 KLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLD 169
           KLF FG R GQ    S+D  Y G GY IRD EL+KIHRAA+KGDAAEVERCL RR  +LD
Sbjct: 2   KLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGELD 61

Query: 170 ARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLE 229
           A D++ RT LHLACA G VQVVTLL++R+CQID+CD+ NRTPL++AVH QEEACA++LLE
Sbjct: 62  ALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLE 121

Query: 230 CGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 289
            GANPN++DIYGNTALHYAVY++ TSLAE+LLSH A+IEAL+K+ NTPLLFAI  +++ M
Sbjct: 122 HGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKM 181

Query: 290 VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALC 349
           VEFLLK +A+ HAVD  +R+AL+LAV ++   IV +LL+QNI + +QDM G+ AEDYA+ 
Sbjct: 182 VEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAIS 241

Query: 350 SDLRSIRQQILEHKNKMLK-----------------NHLRNDNQETAAMKPANL-KKRKE 391
             L  I+QQILEHK K+LK                 + LR D+   +  K  N+  K+  
Sbjct: 242 HHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCV 301

Query: 392 RAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKK----KDAMYGNFMLKKDIAMLKEE 447
             K    L  +S EK  R+   + + P       K     +D      + +K++  L+ E
Sbjct: 302 PEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAE 361

Query: 448 L---YAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKT----VARYSQQLND 500
                A + +  R E+   ++ +     N N  + ++L+E +   T      R +QQ   
Sbjct: 362 QALPVASEEEQQRHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKI 421

Query: 501 LKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVS 560
            K    +   +L KE+H++  L+ E E                                 
Sbjct: 422 GKTYPQQFPKKL-KEEHDRCTLKQENE--------------------------------- 447

Query: 561 RHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKT-LALGSVQLDLR 619
             EK  +N++ L  KN    E+  K   K    K +L  T  +L  K+  A  +   D  
Sbjct: 448 --EK--TNVNMLYKKNREELERKEKQYKKEVEAK-QLEPTVQSLEMKSKTARNTPNWDF- 501

Query: 620 QAQHRIKEMK-QMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKE 678
              H  +EMK  M  N   K   +I +Q     +    E EN  L + ++  ++     E
Sbjct: 502 ---HNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYL-KDIKIVKETNAALE 557

Query: 679 IVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELV-- 736
             I ++ + +        +E N +L  E   L  +LL+ ++ K   E  +  +Q  L   
Sbjct: 558 KYIKLNEEMITETAFRYQQELN-DLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAA 616

Query: 737 -----DHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELIS 791
                + +KT    +  LE T    + +  +    K   + E   E+  E   K   L  
Sbjct: 617 ISKHSESVKTERNLKLALERTQDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKD 676

Query: 792 LLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFK 851
               T D +RKK+  LE       +  + T  M   + N +                   
Sbjct: 677 KFRKTRDSLRKKSLALETVQNNLSQTQQQTQEMKEMYQNAE------------------- 717

Query: 852 KLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLN 911
               K N+   +   V     +L ++N  L Q+L               D    +E+   
Sbjct: 718 ---AKVNNSTGKWNCVEERICHLQRENAWLVQQL---------------DDVHQKEDHKE 759

Query: 912 LKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLK 971
           + T++++  +E GK      E  ++ + E + L+E   Q + E  + +  + +D      
Sbjct: 760 IVTNIQRGFIESGKKDFVLEEKSKKLMNECDHLKESLFQYEREKTEVVVSIKEDKYFQTS 819

Query: 972 KKEL 975
           +K++
Sbjct: 820 RKKI 823



 Score = 32.3 bits (72), Expect = 3.3
 Identities = 43/203 (21%), Positives = 85/203 (41%), Gaps = 44/203 (21%)

Query: 851  KKLKQKFNDLVAEKEAVSSECVNLA--KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEE 908
            KKLK++ +    ++E      VN+   K+ E L ++        EK  K E + K LE  
Sbjct: 431  KKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERK--------EKQYKKEVEAKQLEPT 482

Query: 909  VLNL----KTHMEKDMVELGKLQEYKSELDERAV---------QEIEKLEEIHLQKQAEY 955
            V +L    KT       +    +E K  +DE  +         QEI  ++  +L+K+ +Y
Sbjct: 483  VQSLEMKSKTARNTPNWDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKY 542

Query: 956  EKQLEQLNKDNTASLKKKELT--------------LKDVECKFSKM-------KTAYEEV 994
             K ++ + + N A  K  +L               L D++ + +++       K + + +
Sbjct: 543  LKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRL 602

Query: 995  TTELEEFKEAFAGAVKANNSMSK 1017
              ++E ++   A A+  ++   K
Sbjct: 603  EADIESYQSRLAAAISKHSESVK 625


>gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo
           sapiens]
          Length = 823

 Score =  367 bits (942), Expect = e-101
 Identities = 291/905 (32%), Positives = 436/905 (48%), Gaps = 122/905 (13%)

Query: 110 KLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLD 169
           KLF FG R GQ    S+D  Y G GY IRD EL+KIHRAA+KGDAAEVERCL RR  DLD
Sbjct: 2   KLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLD 61

Query: 170 ARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLE 229
           A D++ RT LHLAC  G VQVVTLL++R+CQID+CD+ NRTPL++AVH QEEACA++LLE
Sbjct: 62  ALDKQHRTALHLACTSGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLE 121

Query: 230 CGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 289
            GANPN++DIYGNTALHYAVY++ TSLAE+LLSH A+IEAL+K+ NTPLLFAI  +++ M
Sbjct: 122 HGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKM 181

Query: 290 VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALC 349
           VEFLLK +A+ HAVD  +R+AL+LAV ++   IV +LL+QNI + +QDM G+ AEDYA+ 
Sbjct: 182 VEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAIS 241

Query: 350 SDLRSIRQQILEHKNKMLK-----------------NHLRNDNQETAAMKPANL-KKRKE 391
             L  I+QQILEHK K+LK                 + LR D+   +  K  N+  K+  
Sbjct: 242 HHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCV 301

Query: 392 RAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKK----KDAMYGNFMLKKDIAMLKEE 447
             K    L  +S EK  R+   + + P       K     +D      + +K++  L+ E
Sbjct: 302 PEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAE 361

Query: 448 LYAIKNDSLRKEKKYIQEIKSITEI----NANFEKSVRLNEKMITKT----VARYSQQLN 499
             A+   S  +++++ +  K   ++    N N  + ++L+E +   T      R +QQ  
Sbjct: 362 -QALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRK 420

Query: 500 DLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDV 559
             K    +   +L KE+H++  L+ E E                                
Sbjct: 421 IGKTYPQQFPKKL-KEEHDRCTLKQENE-------------------------------- 447

Query: 560 SRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKT-LALGSVQLDL 618
              EK  +N++ L  KN    E+  K   K    K +L  T  +L  K+  A  +   D 
Sbjct: 448 ---EK--TNVNMLYKKNREELERKEKQYKKEVEAK-QLEPTVQSLEMKSKTARNTPNWDF 501

Query: 619 RQAQHRIKEMK-QMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNK 677
               H  +EMK  M  N   K   +I +Q     +    E EN  L + ++  ++     
Sbjct: 502 ----HNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYL-KDIKIVKETNAAL 556

Query: 678 EIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELV- 736
           E  I ++ + +        +E N +L  E   L  +LL+ ++ K   E  +  +Q  L  
Sbjct: 557 EKYIKLNEEMITETAFRYQQELN-DLKAENTRLNAELLKEKESKKRLEADIESYQSRLAA 615

Query: 737 ------DHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELI 790
                 + +KT    +  LE T    + +  +    K   + E   E+  E   K   L 
Sbjct: 616 AISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKAENEFLTEQLSETQIKFNALK 675

Query: 791 SLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILF 850
                T D +RKK+  LE       +  + T  M   + N +                  
Sbjct: 676 DKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAE------------------ 717

Query: 851 KKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVL 910
                K N+   +   V     +L ++N  L Q+L               D    +E+  
Sbjct: 718 ----AKVNNSTGKWNCVEERICHLQRENAWLVQQL---------------DDVHQKEDHK 758

Query: 911 NLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASL 970
            + T++++  +E GK      E  ++ + E + L+E   Q + E  + +  + +D     
Sbjct: 759 EIVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQT 818

Query: 971 KKKEL 975
            +K +
Sbjct: 819 SRKTI 823



 Score = 33.1 bits (74), Expect = 1.9
 Identities = 49/238 (20%), Positives = 100/238 (42%), Gaps = 46/238 (19%)

Query: 851  KKLKQKFNDLVAEKEAVSSECVNLA--KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEE 908
            KKLK++ +    ++E      VN+   K+ E L ++        EK  K E + K LE  
Sbjct: 431  KKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERK--------EKQYKKEVEAKQLEPT 482

Query: 909  VLNL----KTHMEKDMVELGKLQEYKSELDERAV---------QEIEKLEEIHLQKQAEY 955
            V +L    KT       +    +E K  +DE  +         QEI  ++  +L+K+ +Y
Sbjct: 483  VQSLEMKSKTARNTPNWDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKY 542

Query: 956  EKQLEQLNKDNTASLKKKELT--------------LKDVECKFSKM-------KTAYEEV 994
             K ++ + + N A  K  +L               L D++ + +++       K + + +
Sbjct: 543  LKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRL 602

Query: 995  TTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPE 1052
              ++E ++   A A+  ++   K   + + K+A+  T+  + +  M   +S +    E
Sbjct: 603  EADIESYQSRLAAAISKHSESVK--TERNLKLALERTRDVSVQVEMSSAISKVKAENE 658


>gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member A5
            [Homo sapiens]
          Length = 823

 Score =  353 bits (906), Expect = 6e-97
 Identities = 306/936 (32%), Positives = 461/936 (49%), Gaps = 133/936 (14%)

Query: 110  KLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLD 169
            KLF F  R GQ +L S+D  Y G GY IR  EL+KIH+AA+KGDAAE+ERCL RR  DLD
Sbjct: 2    KLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLD 61

Query: 170  ARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLE 229
            A D++ RT LHLACA G V+VVTLL++R+CQIDI D+ NRTPL++AVH QEEACA++LLE
Sbjct: 62   ALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLE 121

Query: 230  CGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 289
             GANPN++DIYGNTALHYAVY++ TSLAE+LL H  NIEAL+K+ NTPLLFAI  +++ M
Sbjct: 122  HGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKM 181

Query: 290  VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALC 349
            VEFLLKN+A+ HAVD  + TAL+LAV ++   IV +LL+Q+I + +QDM G+ AEDYA+ 
Sbjct: 182  VEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAIS 241

Query: 350  SDLRSIRQQILEHKNKMLKNHLRN--DNQETAAMKPANLKKRKERAKAEHNLKVASEEKQ 407
              L  I+QQILEHK  +LKN   +   + E+A      L      A  +  L VA+++  
Sbjct: 242  CRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQ-- 299

Query: 408  ERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIK 467
                  +  +P    S+GK    + G           K E    K+ SL          K
Sbjct: 300  --CVPEKVSEPLRGPSHGKGNRIVNG-----------KGEGPPAKHPSL----------K 336

Query: 468  SITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVE 527
              TE+     K             A   + +  L+AE A L    E+E+  +ER E +  
Sbjct: 337  PSTEMEDPAVKG------------AVQXKNVQTLRAEQA-LPVASEEEQQRRERSEKKQP 383

Query: 528  SLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQ-----LTDKNELLT-E 581
             +     T  +E  ++ E          AD +++  K+G    Q     L ++++  T +
Sbjct: 384  QVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRKIGKTYPQQFPKKLKEEHDRCTLK 443

Query: 582  QVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIK-EMKQMHPNGEAKES 640
            Q ++ +   N L  K RE               +L+ ++ Q++ + E KQ+ P  ++ E 
Sbjct: 444  QENEEKTNVNMLHKKNRE---------------ELERKEKQYKKEVEAKQLEPTVQSLEM 488

Query: 641  QSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERN 700
            +    +N+  +     E        +++D   E    +  I I R  +   K D LE+ N
Sbjct: 489  KPKTARNTPNQDFHNHE--------EVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN 540

Query: 701  K-----ELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHC 755
            K     ++ KE N   EK ++  +E   +      +Q+EL D LK            +  
Sbjct: 541  KYLKDIKIAKETNAALEKCIKLNEEMITKTAF--WYQQELND-LKA---------ENTRL 588

Query: 756  HINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYK 815
            +  L +   SKKKL + EI+               S  +  A  I K +  ++ E    K
Sbjct: 589  NSELLKEKESKKKL-EAEIE---------------SYQSRLAAAISKHSENVKTE-RNLK 631

Query: 816  KCLEMTINMLNAF-ANEDFSCHGDLN---TDQL-KMDILFKKLKQKFNDLVAEKEAVSSE 870
              LE T ++      + D S   D N   T+QL KM I F  LK KF             
Sbjct: 632  LALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFNTLKDKFR------------ 679

Query: 871  CVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYK 930
                 K  + L ++ L++  VQ    + ++  K ++E   + +  + K   +   ++E  
Sbjct: 680  -----KTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERI 734

Query: 931  SELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTA 990
             +L        ++L ++H   Q E  K++    +      +KK+L L++   K  K+   
Sbjct: 735  CQLQRENPWLEQQLVDVH---QKEDHKEIVINIQRGFIESRKKDLMLEE---KNKKLMNE 788

Query: 991  YEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKI 1026
            Y+ +   L +++   A  V  +    K    S KK+
Sbjct: 789  YDHLKESLFQYERQKAETV-VSIKEDKYFQTSRKKV 823


>gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member A5
            [Homo sapiens]
          Length = 823

 Score =  353 bits (906), Expect = 6e-97
 Identities = 306/936 (32%), Positives = 461/936 (49%), Gaps = 133/936 (14%)

Query: 110  KLFSFGRRLGQALLSSMDQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLD 169
            KLF F  R GQ +L S+D  Y G GY IR  EL+KIH+AA+KGDAAE+ERCL RR  DLD
Sbjct: 2    KLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDLD 61

Query: 170  ARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLE 229
            A D++ RT LHLACA G V+VVTLL++R+CQIDI D+ NRTPL++AVH QEEACA++LLE
Sbjct: 62   ALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILLE 121

Query: 230  CGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM 289
             GANPN++DIYGNTALHYAVY++ TSLAE+LL H  NIEAL+K+ NTPLLFAI  +++ M
Sbjct: 122  HGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKDSNTPLLFAIICKKEKM 181

Query: 290  VEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALC 349
            VEFLLKN+A+ HAVD  + TAL+LAV ++   IV +LL+Q+I + +QDM G+ AEDYA+ 
Sbjct: 182  VEFLLKNKASTHAVDRLRXTALMLAVHYDSLGIVNILLKQSINVFTQDMCGRDAEDYAIS 241

Query: 350  SDLRSIRQQILEHKNKMLKNHLRN--DNQETAAMKPANLKKRKERAKAEHNLKVASEEKQ 407
              L  I+QQILEHK  +LKN   +   + E+A      L      A  +  L VA+++  
Sbjct: 242  CRLTKIQQQILEHKKMILKNDKPDVGSSDESAVSIFHELCVDSLSALDDELLSVAAKQ-- 299

Query: 408  ERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIK 467
                  +  +P    S+GK    + G           K E    K+ SL          K
Sbjct: 300  --CVPEKVSEPLRGPSHGKGNRIVNG-----------KGEGPPAKHPSL----------K 336

Query: 468  SITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVE 527
              TE+     K             A   + +  L+AE A L    E+E+  +ER E +  
Sbjct: 337  PSTEMEDPAVKG------------AVQXKNVQTLRAEQA-LPVASEEEQQRRERSEKKQP 383

Query: 528  SLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQ-----LTDKNELLT-E 581
             +     T  +E  ++ E          AD +++  K+G    Q     L ++++  T +
Sbjct: 384  QVIEGNNTYKSEKIQLSENICHSTFSAAADRLTQQRKIGKTYPQQFPKKLKEEHDRCTLK 443

Query: 582  QVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIK-EMKQMHPNGEAKES 640
            Q ++ +   N L  K RE               +L+ ++ Q++ + E KQ+ P  ++ E 
Sbjct: 444  QENEEKTNVNMLHKKNRE---------------ELERKEKQYKKEVEAKQLEPTVQSLEM 488

Query: 641  QSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERN 700
            +    +N+  +     E        +++D   E    +  I I R  +   K D LE+ N
Sbjct: 489  KPKTARNTPNQDFHNHE--------EVKDLMDENCILKTDIAILRQEICTMKNDNLEKEN 540

Query: 701  K-----ELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHC 755
            K     ++ KE N   EK ++  +E   +      +Q+EL D LK            +  
Sbjct: 541  KYLKDIKIAKETNAALEKCIKLNEEMITKTAF--WYQQELND-LKA---------ENTRL 588

Query: 756  HINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYK 815
            +  L +   SKKKL + EI+               S  +  A  I K +  ++ E    K
Sbjct: 589  NSELLKEKESKKKL-EAEIE---------------SYQSRLAAAISKHSENVKTE-RNLK 631

Query: 816  KCLEMTINMLNAF-ANEDFSCHGDLN---TDQL-KMDILFKKLKQKFNDLVAEKEAVSSE 870
              LE T ++      + D S   D N   T+QL KM I F  LK KF             
Sbjct: 632  LALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKMQIKFNTLKDKFR------------ 679

Query: 871  CVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYK 930
                 K  + L ++ L++  VQ    + ++  K ++E   + +  + K   +   ++E  
Sbjct: 680  -----KTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKWNCVEERI 734

Query: 931  SELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTA 990
             +L        ++L ++H   Q E  K++    +      +KK+L L++   K  K+   
Sbjct: 735  CQLQRENPWLEQQLVDVH---QKEDHKEIVINIQRGFIESRKKDLMLEE---KNKKLMNE 788

Query: 991  YEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKI 1026
            Y+ +   L +++   A  V  +    K    S KK+
Sbjct: 789  YDHLKESLFQYERQKAETV-VSIKEDKYFQTSRKKV 823


>gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens]
          Length = 917

 Score =  283 bits (724), Expect = 8e-76
 Identities = 263/933 (28%), Positives = 442/933 (47%), Gaps = 118/933 (12%)

Query: 130 YAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQ 189
           ++ PGY +R  +L  IH+AAI GD  +V   +  R  DL+ RD+K+RT L LACAHGR  
Sbjct: 27  FSNPGYRVRQKDLGMIHKAAIAGDVNKVMESILLRLNDLNDRDKKNRTALLLACAHGRPG 86

Query: 190 VVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAV 249
           VV  L+ R+CQ+++ D  NRT L+KAV  QEE CA +LLE GANPN+ D+YGNTALHYA+
Sbjct: 87  VVADLVARKCQLNLTDSENRTALIKAVQCQEEVCASILLEHGANPNVRDMYGNTALHYAI 146

Query: 250 YNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRT 309
            N+  S+A +LL++ A+IEA +++G+T LL A+N +++ MV FLLK + ++ A+DNF RT
Sbjct: 147 DNENISMARKLLAYGADIEARSQDGHTSLLLAVNRKKEQMVSFLLKKKPDLTAIDNFGRT 206

Query: 310 ALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKN 369
           ALILA ++  +S+V  LLQ NI +  QD+ G TAEDYA+ S  ++IR  I E+K    + 
Sbjct: 207 ALILAARNGSTSVVYQLLQHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYKANKRRK 266

Query: 370 HLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKD 429
            L+N N                   +E +L++ SE +QERL+  E+ QPQ  +   K K 
Sbjct: 267 SLQNSN-------------------SEQDLEMTSEGEQERLEGCESSQPQVEE---KMKK 304

Query: 430 AMYGNFMLKKDIAMLKEELYAIKNDSL--RKEKKYIQEIKSITEINANFEKSVR--LNEK 485
                  + +++     + Y    D L  + + +     +S  + N  F++  R   NEK
Sbjct: 305 CRNKKMEVSRNVHADDSDNYNDDVDELIHKIKNRKPDNHQSPGKENGEFDRLARKTSNEK 364

Query: 486 MITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVE 545
              K+   ++  LND+   + + + + E    + E        L         ++  + +
Sbjct: 365 SKVKSQIYFTDDLNDISGSSEKTSEDDELPYSDDENFML----LIKQSGMECKDFVSLSK 420

Query: 546 RKDLELVLWRADDVS---------RHEKMGSNISQL------TDKNELLTE-QVHKARVK 589
            K+      R+ +           + +KM +NIS L      TDK +  +E Q  + + K
Sbjct: 421 SKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKK 480

Query: 590 FNTLKGKLRETR------DALREKTLALGSVQLDLRQAQHRIKEMKQMHPNG---EAKES 640
              L+  L++        + L EK +    +  +  + Q  +K+  ++       E K  
Sbjct: 481 LCNLRFILQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTV 540

Query: 641 QSIGKQN-SLEERIRQQELENLLLERQLEDARKEGD-----NKEIVINIHRD--CLENGK 692
           +S   QN    ER R    EN L+  ++   R E D     N+E      +D   ++   
Sbjct: 541 RSNSNQNFHTHERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENN 600

Query: 693 EDLLE--ERNKELM--------KEYNYLKEK--LLQCEKEKAEREVIVREFQEE------ 734
           EDL +  +RN+E +        KE N L ++  +L  E +K ++ +   E + E      
Sbjct: 601 EDLEKTLKRNEETLTKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRL 660

Query: 735 ---LVDHLKTFSIS---ESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFE 788
              L DH +  S     +   + T +   +L E   S  ++   ++   E          
Sbjct: 661 AAALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKAESTSS-----G 715

Query: 789 LISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDI 848
           L + L+Y  + +++K   +E       +      ++ + + N+       +   Q   D 
Sbjct: 716 LETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDG 775

Query: 849 LFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKC----EKLEKDKKM 904
           LF+        L ++      +C +  K  +   + ++   N+Q KC    EKL+ + + 
Sbjct: 776 LFQ--------LQSQNLLYQQQCNDARKKADNQEKTII---NIQVKCEDTVEKLQAECRK 824

Query: 905 LEEEVLNLKTHMEKDMVELGKLQEYKSELDERAV--QEIEKLEEIHLQKQAEYEKQLE-- 960
           LEE   N K  M++  +   +  +Y+ E +ER V  +++++  +  L KQ   E  LE  
Sbjct: 825 LEE---NNKGLMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDALNKQLLLEAMLEIS 881

Query: 961 ---QLN-KDNTASLKKKELTLKDVECKFSKMKT 989
              ++N +D   SLKKK   ++   C    M T
Sbjct: 882 SERRINLEDEAQSLKKKLGQMRSQVCMKLSMST 914


>gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo
           sapiens]
          Length = 917

 Score =  283 bits (724), Expect = 8e-76
 Identities = 263/933 (28%), Positives = 442/933 (47%), Gaps = 118/933 (12%)

Query: 130 YAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQ 189
           ++ PGY +R  +L  IH+AAI GD  +V   +  R  DL+ RD+K+RT L LACAHGR  
Sbjct: 27  FSNPGYRVRQKDLGMIHKAAIAGDVNKVMESILLRLNDLNDRDKKNRTALLLACAHGRPG 86

Query: 190 VVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAV 249
           VV  L+ R+CQ+++ D  NRT L+KAV  QEE CA +LLE GANPN+ D+YGNTALHYA+
Sbjct: 87  VVADLVARKCQLNLTDSENRTALIKAVQCQEEVCASILLEHGANPNVRDMYGNTALHYAI 146

Query: 250 YNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRT 309
            N+  S+A +LL++ A+IEA +++G+T LL A+N +++ MV FLLK + ++ A+DNF RT
Sbjct: 147 DNENISMARKLLAYGADIEARSQDGHTSLLLAVNRKKEQMVSFLLKKKPDLTAIDNFGRT 206

Query: 310 ALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKN 369
           ALILA ++  +S+V  LLQ NI +  QD+ G TAEDYA+ S  ++IR  I E+K    + 
Sbjct: 207 ALILAARNGSTSVVYQLLQHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYKANKRRK 266

Query: 370 HLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKD 429
            L+N N                   +E +L++ SE +QERL+  E+ QPQ  +   K K 
Sbjct: 267 SLQNSN-------------------SEQDLEMTSEGEQERLEGCESSQPQVEE---KMKK 304

Query: 430 AMYGNFMLKKDIAMLKEELYAIKNDSL--RKEKKYIQEIKSITEINANFEKSVR--LNEK 485
                  + +++     + Y    D L  + + +     +S  + N  F++  R   NEK
Sbjct: 305 CRNKKMEVSRNVHADDSDNYNDDVDELIHKIKNRKPDNHQSPGKENGEFDRLARKTSNEK 364

Query: 486 MITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVE 545
              K+   ++  LND+   + + + + E    + E        L         ++  + +
Sbjct: 365 SKVKSQIYFTDDLNDISGSSEKTSEDDELPYSDDENFML----LIKQSGMECKDFVSLSK 420

Query: 546 RKDLELVLWRADDVS---------RHEKMGSNISQL------TDKNELLTE-QVHKARVK 589
            K+      R+ +           + +KM +NIS L      TDK +  +E Q  + + K
Sbjct: 421 SKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKK 480

Query: 590 FNTLKGKLRETR------DALREKTLALGSVQLDLRQAQHRIKEMKQMHPNG---EAKES 640
              L+  L++        + L EK +    +  +  + Q  +K+  ++       E K  
Sbjct: 481 LCNLRFILQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTV 540

Query: 641 QSIGKQN-SLEERIRQQELENLLLERQLEDARKEGD-----NKEIVINIHRD--CLENGK 692
           +S   QN    ER R    EN L+  ++   R E D     N+E      +D   ++   
Sbjct: 541 RSNSNQNFHTHERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENN 600

Query: 693 EDLLE--ERNKELM--------KEYNYLKEK--LLQCEKEKAEREVIVREFQEE------ 734
           EDL +  +RN+E +        KE N L ++  +L  E +K ++ +   E + E      
Sbjct: 601 EDLEKTLKRNEETLTKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRL 660

Query: 735 ---LVDHLKTFSIS---ESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFE 788
              L DH +  S     +   + T +   +L E   S  ++   ++   E          
Sbjct: 661 AAALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKAESTSS-----G 715

Query: 789 LISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDI 848
           L + L+Y  + +++K   +E       +      ++ + + N+       +   Q   D 
Sbjct: 716 LETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDG 775

Query: 849 LFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKC----EKLEKDKKM 904
           LF+        L ++      +C +  K  +   + ++   N+Q KC    EKL+ + + 
Sbjct: 776 LFQ--------LQSQNLLYQQQCNDARKKADNQEKTII---NIQVKCEDTVEKLQAECRK 824

Query: 905 LEEEVLNLKTHMEKDMVELGKLQEYKSELDERAV--QEIEKLEEIHLQKQAEYEKQLE-- 960
           LEE   N K  M++  +   +  +Y+ E +ER V  +++++  +  L KQ   E  LE  
Sbjct: 825 LEE---NNKGLMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDALNKQLLLEAMLEIS 881

Query: 961 ---QLN-KDNTASLKKKELTLKDVECKFSKMKT 989
              ++N +D   SLKKK   ++   C    M T
Sbjct: 882 SERRINLEDEAQSLKKKLGQMRSQVCMKLSMST 914


>gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo
           sapiens]
          Length = 917

 Score =  282 bits (722), Expect = 1e-75
 Identities = 263/933 (28%), Positives = 442/933 (47%), Gaps = 118/933 (12%)

Query: 130 YAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQ 189
           ++ PGY +R  +L  IH+AAI GD  +V   +  R  DL+ RD+K+RT L LACAHGR  
Sbjct: 27  FSNPGYRVRQKDLGMIHKAAIAGDVNKVMESILLRLNDLNDRDKKNRTALLLACAHGRPG 86

Query: 190 VVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAV 249
           VV  L+ R+CQ+++ D  NRT L+KAV  QEE CA +LLE GANPN+ D+YGNTALHYA+
Sbjct: 87  VVADLVARKCQLNLTDSENRTALIKAVQCQEEVCASILLEHGANPNVRDMYGNTALHYAI 146

Query: 250 YNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRT 309
            N+  S+A +LL++ A+IEA +++G+T LL A+N +++ MV FLLK + ++ A+DNF RT
Sbjct: 147 DNENISMARKLLAYGADIEARSQDGHTSLLLAVNRKKEQMVAFLLKKKPDLTAIDNFGRT 206

Query: 310 ALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKN 369
           ALILA ++  +S+V  LLQ NI +  QD+ G TAEDYA+ S  ++IR  I E+K      
Sbjct: 207 ALILAARNGSTSVVYQLLQHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYKANKRCK 266

Query: 370 HLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKD 429
            L+N N                   +E +L++ SE +QERL+  E+ QPQ  +   K K 
Sbjct: 267 SLQNSN-------------------SEQDLEMTSEGEQERLEGCESSQPQVEE---KMKK 304

Query: 430 AMYGNFMLKKDIAMLKEELYAIKNDSL--RKEKKYIQEIKSITEINANFEKSVR--LNEK 485
                  + +++     + Y    D L  + + +     +S  + N  F++  R   NEK
Sbjct: 305 CRNKKMEVSRNVHADDSDNYNDDVDELIHKIKNRKPDNHQSPGKENGEFDRLARKTSNEK 364

Query: 486 MITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVE 545
              K+   ++  LND+   + + + + E    + E     +E           ++  + +
Sbjct: 365 SKVKSQIYFTDDLNDISGSSEKTSEDDELPYSDDENFMLLIE----QSGMECKDFVSLSK 420

Query: 546 RKDLELVLWRADDVS---------RHEKMGSNISQL------TDKNELLTE-QVHKARVK 589
            K+      R+ +           + +KM +NIS L      TDK +  +E Q  + + K
Sbjct: 421 SKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKK 480

Query: 590 FNTLKGKLRETR------DALREKTLALGSVQLDLRQAQHRIKEMKQMHPNG---EAKES 640
              L+  L++        + L EK +    +  +  + Q  +K+  ++       E K  
Sbjct: 481 LCNLRFILQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTV 540

Query: 641 QSIGKQN-SLEERIRQQELENLLLERQLEDARKEGD-----NKEIVINIHRD--CLENGK 692
           +S   QN    ER R    EN L+  ++   R E D     N+E      +D   ++   
Sbjct: 541 RSNSNQNFHTHERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENN 600

Query: 693 EDLLE--ERNKELM--------KEYNYLKEK--LLQCEKEKAEREVIVREFQEE------ 734
           EDL +  +RN+E +        KE N L ++  +L  E +K ++ +   E + E      
Sbjct: 601 EDLEKTLKRNEEALTKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEMESYRCRL 660

Query: 735 ---LVDHLKTFSIS---ESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFE 788
              L DH +  S     +   + T +   +L E   S  ++   ++   E          
Sbjct: 661 AAALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKAESTSS-----G 715

Query: 789 LISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDI 848
           L + L+Y  + +++K   +E       +      ++ + + N+       +   Q   D 
Sbjct: 716 LETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDG 775

Query: 849 LFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKC----EKLEKDKKM 904
           LF+        L ++      +C +  K  +   + ++   N+Q KC    EKL+ + + 
Sbjct: 776 LFQ--------LQSQNLLYQQQCNDARKKADNQEKTII---NIQVKCEDTVEKLQAECRK 824

Query: 905 LEEEVLNLKTHMEKDMVELGKLQEYKSELDERAV--QEIEKLEEIHLQKQAEYEKQLE-- 960
           LEE   N K  M++  +   +  +Y+ E +ER V  +++++  +  L KQ   E  LE  
Sbjct: 825 LEE---NNKGLMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDALNKQLLLEAMLEIS 881

Query: 961 ---QLN-KDNTASLKKKELTLKDVECKFSKMKT 989
              ++N +D   SLKKK   ++   C    M T
Sbjct: 882 SERRINLEDEAQSLKKKLGQMRSQVCMKLSMST 914


>gi|149363642 coiled-coil domain containing 144A [Homo sapiens]
          Length = 1427

 Score =  271 bits (693), Expect = 3e-72
 Identities = 238/869 (27%), Positives = 413/869 (47%), Gaps = 167/869 (19%)

Query: 245  LHYAVYNKGTSLAERLLSHHANIEALNKEGNT----PLLFAINSRRQHMVEFLLKNQANI 300
            L ++VY     L E+L   + +  +L +  +T      L  + +     +   LK   N+
Sbjct: 610  LSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENM 669

Query: 301  HAV-----DNFKRTALILAVQH-----NLSSIVTLLLQQNIRISSQDM-FGQTAEDYAL- 348
             +V        K+T L L +Q       L  +   L Q+N    + DM + + +E   + 
Sbjct: 670  VSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIK 729

Query: 349  ---CSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEE 405
               C  +   +QQ+  +  +++K      N     ++  N    +++   E + ++  ++
Sbjct: 730  EEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERN--DAQKQLSEEQDARILQDQ 787

Query: 406  ----KQERLQRSENKQPQD-SQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEK 460
                KQ+ L+ +  K   + S  + K+KD  + + ML+++IA+L+ E+  IKN + +KEK
Sbjct: 788  ILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEK 847

Query: 461  KYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKE 520
            KY ++I+++ E N N +K ++LNE+ +T+T+ +YS QLN+L AEN  LNSELE  K N+E
Sbjct: 848  KYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQE 907

Query: 521  RLEAEVESLHSSLATAINEYNEIVERKDLELVLWRA--DDVSRHEKMGSNISQLTDKNEL 578
            RLE E+ES    LA A+ + ++    +DL+L   R   + V  H+KM  ++S L  KNE+
Sbjct: 908  RLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEI 967

Query: 579  LTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAK 638
            L+E++  A  K N+L+ +L  TRDAL  ++L L  VQ DL Q Q + KE +QM+   ++K
Sbjct: 968  LSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSK 1027

Query: 639  ESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDL--- 695
              + I KQ S+EER+ Q + EN+LL +QL+DA K+ +++E   +  +D   +  ++L   
Sbjct: 1028 LKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAE 1087

Query: 696  -------LEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESP 748
                   L+E+NKELM EYN+LKE++ QCEKEKA R++ + E QE +             
Sbjct: 1088 SEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETV------------- 1134

Query: 749  LEGTSHC-HINL-NETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRE 806
                S C H++  NE    ++ LF ++                   +    + ++K  ++
Sbjct: 1135 ---PSRCLHLDAENEVLQLQQTLFSMK------------------AIQKQCETLQKNKKQ 1173

Query: 807  LEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEA 866
            L++E    K  +E   NML     E    H  L  ++ +     K++++K N+ +     
Sbjct: 1174 LKQEVVNLKSYMER--NMLERGKAE---WHKLLIEERAR-----KEIEEKLNEAI----- 1218

Query: 867  VSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVEL-GK 925
                 + L K   V H++L+ +R                E+   ++KT ME  + +L  +
Sbjct: 1219 -----LTLQKQAAVSHEQLVQLR----------------EDNTTSIKTQMELTIKDLESE 1257

Query: 926  LQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFS 985
            +   K+   +    E+E+ +E++L++    E    +L++ N                   
Sbjct: 1258 ISRIKTSQADFNKTELERYKELYLEEVKVRESLSNELSRTN------------------- 1298

Query: 986  KMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLS 1045
                   EV+T+L   KE                                 + R +   +
Sbjct: 1299 ---EMIAEVSTQLTVEKE---------------------------------QTRSRSLFT 1322

Query: 1046 TLPTRPEPELPCVENLNSIE-LNRKYIPK 1073
               TRP  E PCV NLN  E LNRK+IP+
Sbjct: 1323 AYATRPVLESPCVGNLNDSEGLNRKHIPR 1351



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 120/633 (18%), Positives = 268/633 (42%), Gaps = 73/633 (11%)

Query: 372  RNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAM 431
            +N NQ + +    N K  K + +   +L   S+   E     E +Q  D Q +       
Sbjct: 452  KNMNQNSDSGSTNNYKSLKPKLENLSSLPPDSDRTSEVYLHEELQQ--DMQKF------- 502

Query: 432  YGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIK----SITEINANFEKSVR------ 481
                  K ++  L+EE  A+K + ++  K   +E++    + TE++              
Sbjct: 503  ------KNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGNDDD 556

Query: 482  -LNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLE-AEVESLHSSLATAINE 539
             LN+++  K    + +  +    E   + +++  E    + +E +E+ S    L+ ++ E
Sbjct: 557  GLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYE 616

Query: 540  YNEIVERKDLELVLWRADDVSRHEK---MGSNISQLTDKN-ELLTEQVHKARVKFNTLKG 595
             N ++  + L +    +  + R +    +  ++ +L + + + LT ++ +     + L+ 
Sbjct: 617  -NFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQN 675

Query: 596  KLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQ 655
            +L ET+    +  L     + +L   +  +K+      N E + +  +  ++S + RI++
Sbjct: 676  ELSETKKTKLQLELQKIEWEKELYDLRLALKQ-----ENEEKRNADMLYNKDSEQLRIKE 730

Query: 656  QELENLL---------LERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKE 706
            +E   ++         L R +++ R   +N ++V+    D     ++ L EE++  ++++
Sbjct: 731  EECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERND----AQKQLSEEQDARILQD 786

Query: 707  YNYL-KEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTS 765
                 K+K L+  ++K   E+  R  +E+ + H       E  L       I  N+    
Sbjct: 787  QILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIK-NQNKQK 845

Query: 766  KKKLFQVEIQPEEKHEEFRKLFEL------ISLLNYTA--DQIRKKNRELEEEATGYKKC 817
            +KK F+     +EK++  +K+ +L       ++L Y+   + +  +N+ L  E    K+ 
Sbjct: 846  EKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQN 905

Query: 818  LE-MTINMLN---AFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVN 873
             E + I M +     A     C        LK+D  F++ +Q++   V   + +  +   
Sbjct: 906  QERLEIEMESYRCRLAAAVRDCDQSQTARDLKLD--FQRTRQEW---VRLHDKMKVDMSG 960

Query: 874  LAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSEL 933
            L   NE+L ++L    N + K   L+       + +      +E+   +L + Q  K E 
Sbjct: 961  LQAKNEILSEKL---SNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKET 1017

Query: 934  DERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDN 966
            ++    E  KL++ ++ KQ   E++L QL  +N
Sbjct: 1018 EQMYQIEQSKLKK-YIAKQESVEERLSQLQSEN 1049



 Score = 38.9 bits (89), Expect = 0.035
 Identities = 18/36 (50%), Positives = 26/36 (72%)

Query: 384 ANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQ 419
           + L + KE  +AE + ++ SEE+QERL+  ENKQPQ
Sbjct: 211 SQLPENKESKEAEQDSELTSEEEQERLKGCENKQPQ 246



 Score = 34.7 bits (78), Expect = 0.67
 Identities = 18/42 (42%), Positives = 24/42 (57%)

Query: 133 PGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRK 174
           P +D+R  +L ++HRAA  GD   VE  L      +D RDRK
Sbjct: 72  PQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDRK 113


>gi|239741279 PREDICTED: similar to FLJ00310 protein [Homo sapiens]
          Length = 561

 Score =  253 bits (645), Expect = 1e-66
 Identities = 203/592 (34%), Positives = 292/592 (49%), Gaps = 169/592 (28%)

Query: 377 ETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFM 436
           E  A+K A  +K  +  +AE  L VA EE+QER +RSE KQ Q  +              
Sbjct: 131 EDPAVKGAVQRKNVQTLRAEQTLPVALEEEQERCERSEKKQSQVKEG------------- 177

Query: 437 LKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQ 496
                           N++ + EK  IQ  +++    ++        ++ + KT   Y Q
Sbjct: 178 ----------------NNTNKSEK--IQLSENVCHSTSSAAADRLTKQRKVGKT---YPQ 216

Query: 497 QLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRA 556
           Q             +L+KE H++E LE + +           +Y + VE K LE  +   
Sbjct: 217 QFP----------KKLKKE-HDREELERKEK-----------QYKKEVEAKQLEPTVQSL 254

Query: 557 DDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALR---EKTLALGS 613
           D                              +K  T +    +   +LR   +K +   +
Sbjct: 255 D------------------------------MKLKTTRNTPNQINQSLRYSQKKVIGFRN 284

Query: 614 VQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKE 673
              DL Q Q +IKEMK+M+ N EAK + S GK + +EERI Q + EN  +E+QL+D  ++
Sbjct: 285 SPNDLSQTQQQIKEMKEMYENAEAKVNNSTGKWSCVEERICQLQHENPCIEQQLDDVHQK 344

Query: 674 GDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQE 733
            D+KEIV NI R  +E+GK+DL+       ++E N  K+ + +C                
Sbjct: 345 EDHKEIVTNIQRGFIESGKKDLM-------LEEKN--KKLMNEC---------------- 379

Query: 734 ELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLL 793
              DHLK                          + LFQ E          R+  E + ++
Sbjct: 380 ---DHLK--------------------------ESLFQYE----------REKAERVVVV 400

Query: 794 NYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKL 853
                      R+L++EA    K L M  + L   ++     H +L+  Q+    LF+ +
Sbjct: 401 -----------RQLQQEAADSLKKLTMLESPLEGISHY----HINLDETQVPKKKLFQ-V 444

Query: 854 KQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLK 913
           + +F+D +AEKEAVSS+CVNLAK+ +V  QELLSM+ VQ++CEKLE+DKKMLEEE+LNLK
Sbjct: 445 ESQFDDFMAEKEAVSSKCVNLAKEIQVFQQELLSMKKVQQECEKLEEDKKMLEEEILNLK 504

Query: 914 THMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKD 965
           THME  MVEL KLQEYKSELDERA+Q +EKLEEIHLQ+QAE++KQLEQLNKD
Sbjct: 505 THMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAEHKKQLEQLNKD 556


>gi|53828703 POTE ankyrin domain family, member A isoform 2 [Homo
           sapiens]
          Length = 498

 Score =  248 bits (633), Expect = 3e-65
 Identities = 137/292 (46%), Positives = 192/292 (65%), Gaps = 20/292 (6%)

Query: 127 DQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHG 186
           D  +  P Y +R  +L K+HRAA  G+    +  +  R   ++ RD+K RT LHLACA+G
Sbjct: 51  DSAFTEPRYHVRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACANG 110

Query: 187 RVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALH 246
             +VV+LLL R+CQ+ + D   RT L+KAV  QE+ CA++LL+ G +PN+ D+YGNTALH
Sbjct: 111 NSEVVSLLLDRQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNTALH 170

Query: 247 YAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNF 306
           YAVYN+   +A+ LL + A+IE+ NK G TPLL A++ ++Q MV+FL+K +AN++A+D F
Sbjct: 171 YAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANLNALDRF 230

Query: 307 KRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHK-NK 365
            RTALILAV+   +SIV+LLLQQNI + SQD+FGQTAEDYA+ S    I Q + ++K N+
Sbjct: 231 GRTALILAVRCGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLLSDYKENQ 290

Query: 366 MLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQ 417
           M  N   N N                    E +LK+ SEE+ +RL+ SEN Q
Sbjct: 291 MPNNSSGNSN-------------------PEQDLKLTSEEEPQRLKGSENSQ 323


>gi|239745058 PREDICTED: hypothetical protein XP_002343353 [Homo
           sapiens]
          Length = 544

 Score =  243 bits (620), Expect = 9e-64
 Identities = 164/490 (33%), Positives = 261/490 (53%), Gaps = 55/490 (11%)

Query: 127 DQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHG 186
           D  +  P Y +R  +L K+HRAA  G     +  +  R  D++ RD++ RT LHLA A+G
Sbjct: 88  DSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLRDTDMNKRDKQKRTALHLASANG 147

Query: 187 RVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALH 246
             +VV LLL RRCQ+++ D   RT L+KAV  QE+ C ++LLE GA+ NI+D YGNTALH
Sbjct: 148 NSEVVQLLLDRRCQLNVLDNKKRTALIKAVQCQEDECVLMLLEHGADGNIQDEYGNTALH 207

Query: 247 YAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNF 306
           YA+YN+   +A+ LL + A+IE+ NK G TPLL  ++ ++Q +V+FL+K +AN++A+D +
Sbjct: 208 YAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQEVVKFLIKKKANLNALDRY 267

Query: 307 KRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKM 366
            RTALILAV    +SIV LLL+QN+ +SSQD+ GQTA +YA+ S    I + + ++K K 
Sbjct: 268 GRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVICELLSDYKEKQ 327

Query: 367 LKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGK 426
           +                  LK   E +  E +LK+ SEE+ +RL+ SEN QP+      +
Sbjct: 328 M------------------LKISSENSNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPE 369

Query: 427 KKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKM 486
                     + KD     EE          + KK+      + E   N   +   ++ +
Sbjct: 370 ----------INKDCDREVEE----------EIKKHGSNPVGLPENLTNGASAGNGDDGL 409

Query: 487 ITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVER 546
           I +  +R        K EN +      +E H+ E+ + + + L     T I++ +EI+  
Sbjct: 410 IPQRKSR--------KPENQQFPDTENEEYHSDEQNDTQ-KQLSEEQNTGISQ-DEILTN 459

Query: 547 KDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLK-------GKLRE 599
           K  ++ +   +  S           L  +N +L E++ K R++ +  K        K+ E
Sbjct: 460 KQKQIEVAEKEMNSELSLSHKKEEDLLRENSMLREEIAKLRLELDETKHQNQLRENKILE 519

Query: 600 TRDALREKTL 609
             ++++EK L
Sbjct: 520 EIESVKEKLL 529


>gi|52856430 protein expressed in prostate, ovary, testis, and
           placenta 15 [Homo sapiens]
          Length = 581

 Score =  241 bits (616), Expect = 3e-63
 Identities = 163/490 (33%), Positives = 261/490 (53%), Gaps = 55/490 (11%)

Query: 127 DQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHG 186
           D  +  P Y +R  +L K+HRAA  G     +  +  R  D++ RD++ RT LHLA A+G
Sbjct: 125 DSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLRDTDMNKRDKQKRTALHLASANG 184

Query: 187 RVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALH 246
             +VV LLL RRCQ+++ D   RT L+KAV  QE+ C ++LLE GA+ NI+D YGNTALH
Sbjct: 185 NSEVVQLLLDRRCQLNVLDNKKRTALIKAVQCQEDECVLMLLEHGADGNIQDEYGNTALH 244

Query: 247 YAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNF 306
           YA+YN+   +A+ LL + A+IE+ NK G TPLL  ++ ++Q +V+FL+K +AN++A+D +
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 307 KRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKM 366
            RTALILAV    +SIV LLL+QN+ +SSQD+ GQTA +YA+ S    I + + ++K K 
Sbjct: 305 GRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVICELLSDYKEKQ 364

Query: 367 LKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGK 426
           +                  LK   E +  E +LK+ SEE+ +RL+ SEN QP+      +
Sbjct: 365 M------------------LKISSENSNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPE 406

Query: 427 KKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKM 486
                     + KD     EE          + KK+      + E   N   +   ++ +
Sbjct: 407 ----------INKDCDREVEE----------EIKKHGSNPVGLPENLTNGASAGNGDDGL 446

Query: 487 ITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVER 546
           I +  +R        K EN +      +E H+ E+ + + + L     T I++ +EI+  
Sbjct: 447 IPQRKSR--------KPENQQFPDTENEEYHSDEQNDTQ-KQLSEEQNTGISQ-DEILTN 496

Query: 547 KDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLK-------GKLRE 599
           K  ++ +   +  S+          L  +N +L E++   R++ +  K        K+ E
Sbjct: 497 KQKQIEVAEKEMNSKLSLSHKKEEDLLRENSMLREEIAMLRLELDETKHQNQLRENKILE 556

Query: 600 TRDALREKTL 609
             ++++EK L
Sbjct: 557 EIESVKEKLL 566


>gi|209977003 ANKRD26-like family C, member 3 [Homo sapiens]
          Length = 545

 Score =  241 bits (616), Expect = 3e-63
 Identities = 131/294 (44%), Positives = 189/294 (64%), Gaps = 18/294 (6%)

Query: 127 DQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHG 186
           D  +  P Y +R  +L K+HRAA  G     +  +  +  D++ +D++ RT LHLA A+G
Sbjct: 162 DSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLKDTDMNKKDKQKRTALHLASANG 221

Query: 187 RVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALH 246
             +VV LLL RRCQ++I D   RT L KAV  QE+ CA++LLE G +PNI D YGNTALH
Sbjct: 222 NSEVVKLLLDRRCQLNILDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALH 281

Query: 247 YAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNF 306
           YA+YN+   +A+ LL + A+IE+ NK G TPLL  ++ ++Q +V+FL+K +AN++A+D +
Sbjct: 282 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 341

Query: 307 KRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKM 366
            RTALILAV    +SIV+LLL+QNI +SSQD+ GQTA +YA+ S    I Q + ++K K 
Sbjct: 342 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSRHNVICQLLSDYKEKQ 401

Query: 367 LKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQD 420
           +                  LK   E +  E +LK+ SEE+ +RL+ SEN QP++
Sbjct: 402 I------------------LKVSSENSNPEQDLKLTSEEESQRLKGSENSQPEE 437


>gi|52856434 POTE ankyrin domain family, member G [Homo sapiens]
          Length = 508

 Score =  240 bits (613), Expect = 6e-63
 Identities = 130/294 (44%), Positives = 189/294 (64%), Gaps = 18/294 (6%)

Query: 127 DQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHG 186
           D  +  P Y +R  +L K+HRAA  G     +  +  +  D++ +D++ RT LHLA A+G
Sbjct: 125 DSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLKDTDMNKKDKQKRTALHLASANG 184

Query: 187 RVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALH 246
             +VV LLL RRCQ++I D   RT L KAV  +E+ CA++LLE G +PNI D YGNTALH
Sbjct: 185 NSEVVKLLLDRRCQLNILDNKKRTALTKAVQCREDECALMLLEHGTDPNIPDEYGNTALH 244

Query: 247 YAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNF 306
           YA+YN+   +A+ LL + A+IE+ NK G TPLL  ++ ++Q +V+FL+K +AN++A+D +
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 307 KRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKM 366
            RTALILAV    +SIV+LLL+QNI +SSQD+ GQTA +YA+ S    I Q + ++K K 
Sbjct: 305 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHNVICQLLSDYKEKQ 364

Query: 367 LKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQD 420
           +                  LK   E +  E +LK+ SEE+ +RL+ SEN QP++
Sbjct: 365 M------------------LKVSSENSNPEQDLKLTSEEESQRLKGSENSQPEE 400


>gi|239741769 PREDICTED: similar to protein expressed in prostate,
           ovary, testis, and placenta 2 [Homo sapiens]
          Length = 952

 Score =  240 bits (613), Expect = 6e-63
 Identities = 161/469 (34%), Positives = 248/469 (52%), Gaps = 51/469 (10%)

Query: 127 DQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHG 186
           D  +  P Y +R  +L K+HRAA  G  A  +  +  R  D++ +D++ RT LHLA A+G
Sbjct: 125 DSAFVEPRYHVRREDLDKLHRAAWWGKVARKDLIVMLRDTDVNKQDKQKRTALHLASANG 184

Query: 187 RVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALH 246
              VV LLL RRCQ+++ D   RT L KAV  QE+ CA++LLE G +PNI D YGNT LH
Sbjct: 185 NSGVVKLLLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 244

Query: 247 YAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNF 306
           YA+YN+   +A+ LL + A+IE+ NK G TPLL  ++ ++Q +V+FL+K +AN++A+D +
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 307 KRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKM 366
            RTALILAV    +SIV+LLL+QNI +SSQD+ GQTA +YA+ S    I Q + ++K K 
Sbjct: 305 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQ 364

Query: 367 LKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQD-SQSYG 425
           +                  LK   E +  E +LK+ SEE+ +R + SEN QP+  SQ   
Sbjct: 365 M------------------LKISSENSNPEQDLKLTSEEESQRFKGSENSQPEKMSQEPE 406

Query: 426 KKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEK 485
             KD   G+  +++++                  KK+        E   N   +   ++ 
Sbjct: 407 INKD---GDREVEEEM------------------KKHGSTHVGFPENLTNGATAGNGDDG 445

Query: 486 MITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVE 545
           +I    +R  +       EN   +S+ + +   +   E     LH  +     +  E+VE
Sbjct: 446 LIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCEEQNTGILHDEILIHEEKQIEVVE 505

Query: 546 RKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLK 594
           + + EL L       + EK          +N  L E++   R++ +T+K
Sbjct: 506 KMNSELSL-----SCKKEK------DFLHENSTLREEIAMLRLELDTMK 543



 Score = 77.8 bits (190), Expect = 7e-14
 Identities = 82/384 (21%), Positives = 161/384 (41%), Gaps = 43/384 (11%)

Query: 136 DIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLL 195
           ++ D + R     A++    E    L     D +  D    T LH A  +    +   LL
Sbjct: 200 NVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALL 259

Query: 196 HRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTS 255
                I+  ++   TPL+  VH Q++     L++  AN N  D YG TAL  AV     S
Sbjct: 260 LYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSAS 319

Query: 256 LAERLLSHHANIEALNKEGNTPLLFAINSRR----QHMVEFLLKNQANIHAVDNFKRTAL 311
           +   LL  + ++ + +  G T   +A++S      Q + ++  K    I + ++     L
Sbjct: 320 IVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDL 379

Query: 312 ILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKN------K 365
            L  +            Q  ++S +    +  +        R + +++ +H +      +
Sbjct: 380 KLTSEEESQRFKGSENSQPEKMSQEPEINKDGD--------REVEEEMKKHGSTHVGFPE 431

Query: 366 MLKNHLRNDNQETAAMKPANLKK---------------------RKERAKAEHNLKVASE 404
            L N     N +   + P   +                       +++   E N  +  +
Sbjct: 432 NLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCEEQNTGILHD 491

Query: 405 E----KQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEK 460
           E    ++++++  E    + S S  K+KD ++ N  L+++IAML+ EL  +K+ S  ++K
Sbjct: 492 EILIHEEKQIEVVEKMNSELSLSCKKEKDFLHENSTLREEIAMLRLELDTMKHQSQLRKK 551

Query: 461 KYIQEIKSITEINANFEKSVRLNE 484
           KY+++I+S+ + N N  K+++LNE
Sbjct: 552 KYLEDIESVKKKNDNLLKALQLNE 575


>gi|224282147 prostate-specific P704P [Homo sapiens]
          Length = 508

 Score =  240 bits (612), Expect = 8e-63
 Identities = 130/294 (44%), Positives = 188/294 (63%), Gaps = 18/294 (6%)

Query: 127 DQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHG 186
           D  +  P Y +R  +L K+HRAA  G     +  +  +  D++ +D++ RT LHLA A+G
Sbjct: 125 DSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLKDTDMNKKDKQKRTALHLASANG 184

Query: 187 RVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALH 246
             +VV LLL RRCQ++I D   RT L KAV  QE+ CA++LLE G +PNI D YGNTALH
Sbjct: 185 NSEVVKLLLDRRCQLNILDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALH 244

Query: 247 YAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNF 306
           YA+YN+   +A+ LL + A+IE+ NK G TPLL  ++ ++Q +V+FL+K +AN++A+D +
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 307 KRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKM 366
            RT LILAV    +SIV+LLL+QNI +SSQD+ GQTA +YA+ S    I Q + ++K K 
Sbjct: 305 GRTVLILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSRHNVICQLLSDYKEKQ 364

Query: 367 LKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQD 420
           +                  LK   E +  E +LK+ SEE+ +RL+ SEN QP++
Sbjct: 365 I------------------LKVSSENSNPEQDLKLTSEEESQRLKGSENSQPEE 400


>gi|134133226 protein expressed in prostate, ovary, testis, and
           placenta 2 [Homo sapiens]
          Length = 1075

 Score =  239 bits (610), Expect = 1e-62
 Identities = 133/304 (43%), Positives = 190/304 (62%), Gaps = 19/304 (6%)

Query: 127 DQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHG 186
           D  +  P Y +R  +L K+HRAA  G     +  +  R  D++ +D++ RT LHLA A+G
Sbjct: 125 DSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKKDKQKRTALHLASANG 184

Query: 187 RVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALH 246
             +VV LLL RRCQ+++ D   RT L+KAV  QE+ CA++LLE G +PNI D YGNT LH
Sbjct: 185 NSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 244

Query: 247 YAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNF 306
           YA+YN+   +A+ LL + A+IE+ NK G TPLL  ++ ++Q +V+FL+K +AN++A+D +
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 307 KRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKM 366
            RTALILAV    +SIV+LLL+QNI +SSQD+ GQTA +YA+ S    I Q + ++K K 
Sbjct: 305 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQ 364

Query: 367 LKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQD-SQSYG 425
           +                  LK   E +  E  LK+ SEE+ +R + SEN QP+  SQ   
Sbjct: 365 M------------------LKISSENSNPEQELKLTSEEESQRFKGSENSQPEKMSQELE 406

Query: 426 KKKD 429
             KD
Sbjct: 407 INKD 410



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 39/128 (30%), Positives = 71/128 (55%), Gaps = 10/128 (7%)

Query: 357 QQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENK 416
           QQ  + +N+   +  +ND Q+            ++     H+  +  EEKQ  ++  E  
Sbjct: 581 QQFPDTENEEYHSDEQNDTQKQFC--------EEQNTGILHDEILIHEEKQ--IEVVEKM 630

Query: 417 QPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANF 476
             + S S  K+KD ++ N  L+++IAML+ EL  +K+ S  +EKKY+++I+S+ + N N 
Sbjct: 631 NSELSLSCKKEKDVLHENSTLREEIAMLRLELDTMKHQSQLREKKYLEDIESVKKKNDNL 690

Query: 477 EKSVRLNE 484
            K+++LNE
Sbjct: 691 LKALQLNE 698


>gi|153791352 prostate, ovary, testis expressed protein on
           chromosome 2 [Homo sapiens]
          Length = 1075

 Score =  239 bits (609), Expect = 2e-62
 Identities = 129/293 (44%), Positives = 187/293 (63%), Gaps = 18/293 (6%)

Query: 127 DQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHG 186
           D  +  P Y +R  +L K+HRAA  G     +  +  R  D++ +D++ RT LHLA A+G
Sbjct: 125 DSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKQDKQKRTALHLASANG 184

Query: 187 RVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALH 246
             +VV LLL RRCQ+++ D   RT L+KAV  QE+ CA++LLE G +PNI D YGNT LH
Sbjct: 185 NSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 244

Query: 247 YAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNF 306
           YA+YN+   +A+ LL + A+IE+ NK G TPLL  ++ ++Q +V+FL+K +AN++A+D +
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 307 KRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKM 366
            RTALILAV    +SIV+LLL+QNI +SSQD+ GQTA +YA+ S    I Q + ++K K 
Sbjct: 305 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQ 364

Query: 367 LKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQ 419
           +                  LK   E +  E +LK+ SEE+ +R + SEN QP+
Sbjct: 365 M------------------LKISSENSNPEQDLKLTSEEESQRFKGSENSQPE 399



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 105/500 (21%), Positives = 186/500 (37%), Gaps = 71/500 (14%)

Query: 144 KIHRAAIKGDAAEVERC---LTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQ 200
           K   A IK    + + C   L     D +  D    T LH A  +    +   LL     
Sbjct: 205 KKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGAD 264

Query: 201 IDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERL 260
           I+  ++   TPL+  VH Q++     L++  AN N  D YG TAL  AV     S+   L
Sbjct: 265 IESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLL 324

Query: 261 LSHHANIEALNKEGNTPLLFAINSRR----QHMVEFLLKNQANIHAVDNFKRTALILAVQ 316
           L  + ++ + +  G T   +A++S      Q + ++  K    I + ++     L L  +
Sbjct: 325 LEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDLKLTSE 384

Query: 317 HNLSSIVTLLLQQNIRISSQ-------------DMFGQTAEDYALCSDLRS-------IR 356
                       Q  ++S +             +M    + +  L  +L +         
Sbjct: 385 EESQRFKGSENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGNGDN 444

Query: 357 QQILEHKNKMLKNHLRNDNQETAAMKPANL----------KKRKERAKAEHNLKVASEEK 406
             I + K++  +N    DN+     +   L          K   E +  E +LK+ SEE+
Sbjct: 445 GLIPQRKSRTPENQQFPDNESEEYHRICELLSDYKEKQMPKYSSENSNPEQDLKLTSEEE 504

Query: 407 QERLQRSENKQPQ---DSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYI 463
            +RL+ SEN QP+         K  D    NFM                  ++ + KK+ 
Sbjct: 505 SQRLKGSENGQPEKRSQEPEINKDGDRELENFM------------------AIEEMKKHR 546

Query: 464 QEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLE 523
                  E   N   +   ++ +I    +R  +       EN   +S+ + +   +   E
Sbjct: 547 STHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCEE 606

Query: 524 AEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQV 583
                LH  +     +  E+VE+ + EL L       + EK       +  +N  L E++
Sbjct: 607 QNTGILHDEILIHEEKQIEVVEKMNSELSL-----SCKKEK------DILHENSTLREEI 655

Query: 584 HKARVKFNTLK--GKLRETR 601
              R++ +T+K   +LRE +
Sbjct: 656 AMLRLELDTMKHQSQLREKK 675



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 39/128 (30%), Positives = 71/128 (55%), Gaps = 10/128 (7%)

Query: 357 QQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENK 416
           QQ  + +N+   +  +ND Q+            ++     H+  +  EEKQ  ++  E  
Sbjct: 581 QQFPDTENEEYHSDEQNDTQKQFC--------EEQNTGILHDEILIHEEKQ--IEVVEKM 630

Query: 417 QPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANF 476
             + S S  K+KD ++ N  L+++IAML+ EL  +K+ S  +EKKY+++I+S+ + N N 
Sbjct: 631 NSELSLSCKKEKDILHENSTLREEIAMLRLELDTMKHQSQLREKKYLEDIESVKKRNDNL 690

Query: 477 EKSVRLNE 484
            K+++LNE
Sbjct: 691 LKALQLNE 698


>gi|113413200 PREDICTED: similar to protein expressed in prostate,
           ovary, testis, and placenta 2 [Homo sapiens]
          Length = 1038

 Score =  238 bits (608), Expect = 2e-62
 Identities = 130/293 (44%), Positives = 186/293 (63%), Gaps = 18/293 (6%)

Query: 127 DQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHG 186
           D  +  P Y +R  +L K+HRAA  G  A  +  +  R  D++ +D++ RT LHLA A+G
Sbjct: 88  DSAFVEPRYHVRREDLDKLHRAAWWGKVARKDLIVMLRDTDVNKQDKQKRTALHLASANG 147

Query: 187 RVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALH 246
              VV LLL RRCQ+++ D   RT L KAV  QE+ CA++LLE G +PNI D YGNT LH
Sbjct: 148 NSGVVKLLLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 207

Query: 247 YAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNF 306
           YA+YN+   +A+ LL + A+IE+ NK G TPLL  ++ ++Q +V+FL+K +AN++A+D +
Sbjct: 208 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 267

Query: 307 KRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKM 366
            RTALILAV    +SIV+LLL+QNI +SSQD+ GQTA +YA+ S    I Q + ++K K 
Sbjct: 268 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQ 327

Query: 367 LKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQ 419
           +                  LK   E +  E +LK+ SEE+ +R + SEN QP+
Sbjct: 328 M------------------LKISSENSNPEQDLKLTSEEESQRFKGSENSQPE 362



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 100/496 (20%), Positives = 183/496 (36%), Gaps = 66/496 (13%)

Query: 136 DIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLL 195
           ++ D + R     A++    E    L     D +  D    T LH A  +    +   LL
Sbjct: 163 NVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALL 222

Query: 196 HRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTS 255
                I+  ++   TPL+  VH Q++     L++  AN N  D YG TAL  AV     S
Sbjct: 223 LYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSAS 282

Query: 256 LAERLLSHHANIEALNKEGNTPLLFAINSRR----QHMVEFLLKNQANIHAVDNFKRTAL 311
           +   LL  + ++ + +  G T   +A++S      Q + ++  K    I + ++     L
Sbjct: 283 IVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDL 342

Query: 312 ILAVQHNLSSIVTLLLQQNIRISSQ-------------DMFGQTAEDYALCSDLRSIRQQ 358
            L  +            Q  ++S +             +M    + +  L  +L +    
Sbjct: 343 KLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLSNGVTA 402

Query: 359 -------ILEHKNKMLKNHLRNDNQETAAMKPANL----------KKRKERAKAEHNLKV 401
                  I + K++  +N    DN+     +   L          K   E +  E +LK+
Sbjct: 403 GNGDDGLIPQRKSRTPENQQFPDNESEEYHRICELVSDYKEKQMPKYSSENSNPEQDLKL 462

Query: 402 ASEEKQERLQRSENKQPQ---DSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRK 458
            SEE+ +RL+ SEN QP+         K  D    NFM                  ++ +
Sbjct: 463 TSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFM------------------AIEE 504

Query: 459 EKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHN 518
            KK+        E   N   +   ++ +I    +R  +       EN   +S+ + +   
Sbjct: 505 MKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQK 564

Query: 519 KERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNEL 578
           +   E     LH  +     +  E+VE+ + EL L       + E+          +N +
Sbjct: 565 QFCEEQNTGILHDEILIHEEKQIEVVEKMNSELSL-----SCKKER------DFLHENSM 613

Query: 579 LTEQVHKARVKFNTLK 594
           L E++   R++ +T+K
Sbjct: 614 LREEIAMLRLELDTMK 629



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 38/128 (29%), Positives = 72/128 (56%), Gaps = 10/128 (7%)

Query: 357 QQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENK 416
           QQ  + +N+   +  +ND Q+            ++     H+  +  EEKQ  ++  E  
Sbjct: 544 QQFPDTENEEYHSDEQNDTQKQFC--------EEQNTGILHDEILIHEEKQ--IEVVEKM 593

Query: 417 QPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANF 476
             + S S  K++D ++ N ML+++IAML+ EL  +K+ S  ++KKY+++I+S+ + N N 
Sbjct: 594 NSELSLSCKKERDFLHENSMLREEIAMLRLELDTMKHQSQLRKKKYLEDIESVKKKNDNL 653

Query: 477 EKSVRLNE 484
            K+++LNE
Sbjct: 654 LKALQLNE 661


>gi|88953571 PREDICTED: similar to protein expressed in prostate,
           ovary, testis, and placenta 2 isoform 2 [Homo sapiens]
          Length = 1075

 Score =  238 bits (608), Expect = 2e-62
 Identities = 130/293 (44%), Positives = 186/293 (63%), Gaps = 18/293 (6%)

Query: 127 DQEYAGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHG 186
           D  +  P Y +R  +L K+HRAA  G  A  +  +  R  D++ +D++ RT LHLA A+G
Sbjct: 125 DSAFVEPRYHVRREDLDKLHRAAWWGKVARKDLIVMLRDTDVNKQDKQKRTALHLASANG 184

Query: 187 RVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALH 246
              VV LLL RRCQ+++ D   RT L KAV  QE+ CA++LLE G +PNI D YGNT LH
Sbjct: 185 NSGVVKLLLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLH 244

Query: 247 YAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNF 306
           YA+YN+   +A+ LL + A+IE+ NK G TPLL  ++ ++Q +V+FL+K +AN++A+D +
Sbjct: 245 YAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY 304

Query: 307 KRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKM 366
            RTALILAV    +SIV+LLL+QNI +SSQD+ GQTA +YA+ S    I Q + ++K K 
Sbjct: 305 GRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQ 364

Query: 367 LKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQ 419
           +                  LK   E +  E +LK+ SEE+ +R + SEN QP+
Sbjct: 365 M------------------LKISSENSNPEQDLKLTSEEESQRFKGSENSQPE 399



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 101/496 (20%), Positives = 182/496 (36%), Gaps = 66/496 (13%)

Query: 136 DIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLL 195
           ++ D + R     A++    E    L     D +  D    T LH A  +    +   LL
Sbjct: 200 NVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALL 259

Query: 196 HRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTS 255
                I+  ++   TPL+  VH Q++     L++  AN N  D YG TAL  AV     S
Sbjct: 260 LYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSAS 319

Query: 256 LAERLLSHHANIEALNKEGNTPLLFAINSRR----QHMVEFLLKNQANIHAVDNFKRTAL 311
           +   LL  + ++ + +  G T   +A++S      Q + ++  K    I + ++     L
Sbjct: 320 IVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDL 379

Query: 312 ILAVQHNLSSIVTLLLQQNIRISSQ-------------DMFGQTAEDYALCSDLRSIRQQ 358
            L  +            Q  ++S +             +M    + +  L  +L +    
Sbjct: 380 KLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLSNGVTA 439

Query: 359 -------ILEHKNKMLKNHLRNDNQETAAMKPANL----------KKRKERAKAEHNLKV 401
                  I + K++  +N    DN+     +   L          K   E +  E +LK+
Sbjct: 440 GNGDDGLIPQRKSRTPENQQFPDNESEEYHRICELVSDYKEKQMPKYSSENSNPEQDLKL 499

Query: 402 ASEEKQERLQRSENKQPQ---DSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRK 458
            SEE+ +RL+ SEN QP+         K  D    NFM                  ++ +
Sbjct: 500 TSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFM------------------AIEE 541

Query: 459 EKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHN 518
            KK+        E   N   +   ++ +I    +R  +       EN   +S+ + +   
Sbjct: 542 MKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQK 601

Query: 519 KERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNEL 578
           +   E     LH  +     +  E+VE+ + EL L       + EK          +N  
Sbjct: 602 QFCEEQNTGILHDEILIHEEKQIEVVEKMNSELSL-----SCKKEK------DFLHENST 650

Query: 579 LTEQVHKARVKFNTLK 594
           L E++   R++ +T+K
Sbjct: 651 LREEIAMLRLELDTMK 666



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 38/128 (29%), Positives = 71/128 (55%), Gaps = 10/128 (7%)

Query: 357 QQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENK 416
           QQ  + +N+   +  +ND Q+            ++     H+  +  EEKQ  ++  E  
Sbjct: 581 QQFPDTENEEYHSDEQNDTQKQFC--------EEQNTGILHDEILIHEEKQ--IEVVEKM 630

Query: 417 QPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANF 476
             + S S  K+KD ++ N  L+++IAML+ EL  +K+ S  ++KKY+++I+S+ + N N 
Sbjct: 631 NSELSLSCKKEKDFLHENSTLREEIAMLRLELDTMKHQSQLRKKKYLEDIESVKKKNDNL 690

Query: 477 EKSVRLNE 484
            K+++LNE
Sbjct: 691 LKALQLNE 698


>gi|239747812 PREDICTED: ankyrin repeat domain 36 [Homo sapiens]
          Length = 753

 Score =  236 bits (602), Expect = 1e-61
 Identities = 166/440 (37%), Positives = 235/440 (53%), Gaps = 35/440 (7%)

Query: 7   PSQAVYPAAAAPG----------------QEPTPQSHPRWLRRAPVSG-PDLSSEEERVG 49
           PS  + P +A PG                +  T Q HP W    P  G P + S  +R  
Sbjct: 196 PSSRLAPISADPGGDAVAKWGCGPSGGTRRRSTTQPHP-WAAEGPARGTPSVGSLWKRRA 254

Query: 50  SQGQAGPQAGRDALLGFRDVPREPRRTRKPATRAPVLQVPPAGHEGLGAASGVPAVATMR 109
              Q     GR A L  +  P  P R    AT A   +   A    L  A      A +R
Sbjct: 255 RGRQLNRPWGR-ARLALQGAP--PSRGTSAATAACTGRARAARAVSLPRACWA-GPAKVR 310

Query: 110 KLFSFG----------RRLGQALLSSMDQE-YAGPGYDIRDWELRKIHRAAIKGDAAEVE 158
            L  +           R     L+  +  + +A P Y I+ + L++IHRA + G+  +++
Sbjct: 311 VLAGYNLQPTIKEDDERERWPTLMERLCSDGFAFPHYYIKPYHLKRIHRAVLHGNLEKLK 370

Query: 159 RCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHS 218
             L   + D + RDRK+RT LHLACA G+ ++V LL+ RRC++++CDR +RTPL+KAV  
Sbjct: 371 YLLLTYY-DANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQL 429

Query: 219 QEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPL 278
           ++EACA +LL+ GANPNI D +G TALHYAVYN+ TS+ E+LLSH  NIE  +K    PL
Sbjct: 430 RQEACATLLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPL 489

Query: 279 LFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDM 338
           LFA++ R+  MVEFLLK +AN++A+D   R+ALI AV      IV LLLQ NI + S+D 
Sbjct: 490 LFAVSRRKVKMVEFLLKKKANVNAIDYLGRSALIHAVTLGEKDIVILLLQHNIDVLSRDA 549

Query: 339 FGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHN 398
           F + A DYA+ +  R I   I E+K K  ++   N N  ++  +PA LK    +  +  N
Sbjct: 550 FRKIAGDYAIEAKNRVIFDLIYEYKRKRYEDLPINSNPVSSQKQPA-LKATSGKEDSISN 608

Query: 399 LKVASEEKQERLQRSENKQP 418
           +    ++ Q+    S  KQP
Sbjct: 609 IATEIKDGQKSGTVSSQKQP 628


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.130    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,911,061
Number of Sequences: 37866
Number of extensions: 2683675
Number of successful extensions: 27501
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 535
Number of HSP's successfully gapped in prelim test: 1217
Number of HSP's that attempted gapping in prelim test: 13904
Number of HSP's gapped (non-prelim): 7745
length of query: 1415
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1300
effective length of database: 13,892,928
effective search space: 18060806400
effective search space used: 18060806400
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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