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Search of human proteins with 116284384
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116284384 G protein-coupled bile acid receptor 1 [Homo
sapiens]
(330 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116284382 G protein-coupled bile acid receptor 1 [Homo sapiens] 664 0.0
gi|116284384 G protein-coupled bile acid receptor 1 [Homo sapiens] 664 0.0
gi|24850109 G protein-coupled bile acid receptor 1 [Homo sapiens] 664 0.0
gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo sa... 68 1e-11
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 57 2e-08
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 57 2e-08
gi|4501951 adenosine A2b receptor [Homo sapiens] 56 4e-08
gi|13540517 endothelial differentiation, sphingolipid G-protein-... 55 9e-08
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 54 2e-07
gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens] 49 5e-06
gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens] 49 5e-06
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 49 8e-06
gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens] 48 1e-05
gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens] 48 1e-05
gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens] 48 1e-05
gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens] 48 1e-05
gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens] 48 1e-05
gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens] 48 1e-05
gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens] 48 1e-05
gi|36951034 G protein-coupled receptor 78 [Homo sapiens] 48 1e-05
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 47 2e-05
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 47 2e-05
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 47 2e-05
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 47 2e-05
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 47 2e-05
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 47 2e-05
gi|4557865 somatostatin receptor 5 [Homo sapiens] 45 7e-05
gi|9789897 leukotriene B4 receptor 2 [Homo sapiens] 45 7e-05
gi|223633986 trace amine associated receptor 5 [Homo sapiens] 45 7e-05
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 45 9e-05
>gi|116284382 G protein-coupled bile acid receptor 1 [Homo sapiens]
Length = 330
Score = 664 bits (1712), Expect = 0.0
Identities = 330/330 (100%), Positives = 330/330 (100%)
Query: 1 MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA 60
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA
Sbjct: 1 MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA 60
Query: 61 GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP 120
GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP
Sbjct: 61 GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP 120
Query: 121 PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA 180
PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA
Sbjct: 121 PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA 180
Query: 181 AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY 240
AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY
Sbjct: 181 AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY 240
Query: 241 VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ 300
VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ
Sbjct: 241 VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ 300
Query: 301 GLWGRASRDSPGPSIAYHPSSQSSVDLDLN 330
GLWGRASRDSPGPSIAYHPSSQSSVDLDLN
Sbjct: 301 GLWGRASRDSPGPSIAYHPSSQSSVDLDLN 330
>gi|116284384 G protein-coupled bile acid receptor 1 [Homo sapiens]
Length = 330
Score = 664 bits (1712), Expect = 0.0
Identities = 330/330 (100%), Positives = 330/330 (100%)
Query: 1 MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA 60
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA
Sbjct: 1 MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA 60
Query: 61 GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP 120
GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP
Sbjct: 61 GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP 120
Query: 121 PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA 180
PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA
Sbjct: 121 PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA 180
Query: 181 AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY 240
AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY
Sbjct: 181 AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY 240
Query: 241 VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ 300
VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ
Sbjct: 241 VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ 300
Query: 301 GLWGRASRDSPGPSIAYHPSSQSSVDLDLN 330
GLWGRASRDSPGPSIAYHPSSQSSVDLDLN
Sbjct: 301 GLWGRASRDSPGPSIAYHPSSQSSVDLDLN 330
>gi|24850109 G protein-coupled bile acid receptor 1 [Homo sapiens]
Length = 330
Score = 664 bits (1712), Expect = 0.0
Identities = 330/330 (100%), Positives = 330/330 (100%)
Query: 1 MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA 60
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA
Sbjct: 1 MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA 60
Query: 61 GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP 120
GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP
Sbjct: 61 GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP 120
Query: 121 PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA 180
PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA
Sbjct: 121 PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA 180
Query: 181 AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY 240
AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY
Sbjct: 181 AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY 240
Query: 241 VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ 300
VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ
Sbjct: 241 VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ 300
Query: 301 GLWGRASRDSPGPSIAYHPSSQSSVDLDLN 330
GLWGRASRDSPGPSIAYHPSSQSSVDLDLN
Sbjct: 301 GLWGRASRDSPGPSIAYHPSSQSSVDLDLN 330
>gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo
sapiens]
Length = 384
Score = 68.2 bits (165), Expect = 1e-11
Identities = 81/268 (30%), Positives = 115/268 (42%), Gaps = 25/268 (9%)
Query: 16 GAL-GLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGL 74
GAL GLS+A + L++ NLL+ I R R C +++ L+ LLTG A L
Sbjct: 47 GALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCL-VNITLSDLLTGAAY-LANVL 104
Query: 75 WNQSRRGYWSCLLVYLAPNFSFLSLLAN---LLLVHGERYMAVLRPLQPPGSIRLALL-- 129
+ +R + +L F +L A+ LL GER+ ++RP+ G+ + + +
Sbjct: 105 LSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYG 164
Query: 130 ---LTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSV 186
L W L LP LGWN CSS + P LY + Y L + A
Sbjct: 165 FIGLCWLLAALLGMLPLLGWNCLCAFDRCSS--LLP---LYSKRYILFCLVIFAG----- 214
Query: 187 RVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLL 246
VLAT I RL +A + P AR R + +L F +CWGP LL
Sbjct: 215 -VLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLA 273
Query: 247 SVLA---YEQRPPLGPGTLLSLLSLGSA 271
V + Q G +L+L L SA
Sbjct: 274 DVFGSNLWAQEYLRGMDWILALAVLNSA 301
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 57.4 bits (137), Expect = 2e-08
Identities = 65/264 (24%), Positives = 115/264 (43%), Gaps = 38/264 (14%)
Query: 1 MTPNSTGE---VPSPIPKGALGLSLALASLIITA-NLLLALGIAWDRRLRSPPAGCFFLS 56
M PN T + S K + + LA+ LI A N+++ L + +RRLR+ CF +S
Sbjct: 1 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNL-TNCFIVS 59
Query: 57 LLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLA---NLLLVHGERYMA 113
L + LL GL + ++ S + + + + + + A NL ++ +RY A
Sbjct: 60 LAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCA 119
Query: 114 VLRPLQ-----PPGSIRLALLLTWAGPLLFASLPA-LGW---NHWTPGANCSSQAIFPAP 164
V+ PL+ P + ++L+L W + + L LGW N + G + +S+
Sbjct: 120 VMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVN 179
Query: 165 YLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQAR 224
EVYGL+ V +L + ++ + ++ V RD+ + +W+ A
Sbjct: 180 ----EVYGLVDGLV--TFYLPLLIMCITYYRI-------FKVARDQAKRINHISSWKAAT 226
Query: 225 AQ--------AGAMLLFGLCWGPY 240
+ A M F +CW PY
Sbjct: 227 IREHKATVTLAAVMGAFIICWFPY 250
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 57.4 bits (137), Expect = 2e-08
Identities = 65/264 (24%), Positives = 115/264 (43%), Gaps = 38/264 (14%)
Query: 1 MTPNSTGE---VPSPIPKGALGLSLALASLIITA-NLLLALGIAWDRRLRSPPAGCFFLS 56
M PN T + S K + + LA+ LI A N+++ L + +RRLR+ CF +S
Sbjct: 1 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNL-TNCFIVS 59
Query: 57 LLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLA---NLLLVHGERYMA 113
L + LL GL + ++ S + + + + + + A NL ++ +RY A
Sbjct: 60 LAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCA 119
Query: 114 VLRPLQ-----PPGSIRLALLLTWAGPLLFASLPA-LGW---NHWTPGANCSSQAIFPAP 164
V+ PL+ P + ++L+L W + + L LGW N + G + +S+
Sbjct: 120 VMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVN 179
Query: 165 YLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQAR 224
EVYGL+ V +L + ++ + ++ V RD+ + +W+ A
Sbjct: 180 ----EVYGLVDGLV--TFYLPLLIMCITYYRI-------FKVARDQAKRINHISSWKAAT 226
Query: 225 AQ--------AGAMLLFGLCWGPY 240
+ A M F +CW PY
Sbjct: 227 IREHKATVTLAAVMGAFIICWFPY 250
>gi|4501951 adenosine A2b receptor [Homo sapiens]
Length = 332
Score = 56.2 bits (134), Expect = 4e-08
Identities = 67/298 (22%), Positives = 119/298 (39%), Gaps = 35/298 (11%)
Query: 18 LGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGL-ALPTLPGLWN 76
+ L L +A+L + N+L+ + L++P F +SL A + GL A+P +
Sbjct: 11 VALELVIAALSVAGNVLVCAAVGTANTLQTP-TNYFLVSLAAADVAVGLFAIPFAITISL 69
Query: 77 QSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSI-----RLALLLT 131
++ CL + S + +LL V +RY+A+ PL+ + R + +
Sbjct: 70 GFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVL 129
Query: 132 WAGPLLFASLPALGWNHWTPGAN------------------CSSQAIFPAPYL-YLEVYG 172
W P LGWN N C + + P Y+ Y +G
Sbjct: 130 WVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFG 189
Query: 173 LLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLL 232
+LP + + +++ A RQLQ ++ + + L R + A++ A + +
Sbjct: 190 CVLPPLLIMLVIYIKIFLVACRQLQRTELMDHS-----RTTLQREI--HAAKSLAMIVGI 242
Query: 233 FGLCWGPYVATLLLSVL--AYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYT 288
F LCW P A +++ A + P + LLS ++ + A D RYT
Sbjct: 243 FALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT 300
>gi|13540517 endothelial differentiation, sphingolipid
G-protein-coupled receptor, 8 [Homo sapiens]
Length = 398
Score = 55.1 bits (131), Expect = 9e-08
Identities = 73/247 (29%), Positives = 96/247 (38%), Gaps = 35/247 (14%)
Query: 22 LALASLIITANLLLALGIAWDRRLRSPP---AGCFFLSLLLAG-------LLTG-LALPT 70
LA+ + I+ NL + L + R +P G LS LLAG LL+G L L
Sbjct: 44 LAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKL 103
Query: 71 LPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLR----PLQPPGSIRL 126
P LW G V++A S LSLLA L ER + + R P+ G
Sbjct: 104 SPALWFAREGG------VFVALTASVLSLLAIAL----ERSLTMARRGPAPVSSRGRTLA 153
Query: 127 ALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGL--LLPAVG---AA 181
W LL LPALGWN CS+ + P LY + Y L +L VG A
Sbjct: 154 MAAAAWGVSLLLGLLPALGWNCLGRLDACST--VLP---LYAKAYVLFCVLAFVGILAAI 208
Query: 182 AFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYV 241
L R+ + + A + + R + +L F CWGP
Sbjct: 209 CALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLF 268
Query: 242 ATLLLSV 248
LLL V
Sbjct: 269 LLLLLDV 275
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 53.9 bits (128), Expect = 2e-07
Identities = 88/328 (26%), Positives = 127/328 (38%), Gaps = 58/328 (17%)
Query: 2 TPNSTGEVPSPIPKGALGLSLALASLI-ITANLLLALGIAWDRRLRSPPAGCFFLSLLLA 60
T N++G P G LALA L + NLL+ + IAW RL++ F SL A
Sbjct: 24 TANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQT-MTNVFVTSLAAA 82
Query: 61 GLLTGLALPTLPGLWNQSRRGYW-----SCLLVYLAPNFSFLSLLANLLLVHGERYMAVL 115
L+ GL + +P + G+W C L + + L + +RY+AV
Sbjct: 83 DLVMGLLV--VPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVT 140
Query: 116 RPLQPPGSI-----RLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAP----YL 166
PL+ + R A++L W + P + W GA+ +Q P +
Sbjct: 141 NPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMS-QWWRVGADAEAQRCHSNPRCCAFA 199
Query: 167 YLEVYGLLLPAVG------AAAFLSVRVLATAHRQLQDI-CRLERAVCRDEPSA------ 213
Y LL +V F+ RV A RQL+ + L R + P A
Sbjct: 200 SNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLA 259
Query: 214 -------------------LARALTWRQARAQAGAMLLFG---LCWGPYVATLLLSVLAY 251
AR L R+ RA L+ G LCW P+ L +VL
Sbjct: 260 PAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPF---FLANVLRA 316
Query: 252 EQRPPLGPG-TLLSLLSLGSASAAAVPV 278
P L PG L+L LG A++A P+
Sbjct: 317 LGGPSLVPGPAFLALNWLGYANSAFNPL 344
>gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens]
Length = 364
Score = 49.3 bits (116), Expect = 5e-06
Identities = 74/300 (24%), Positives = 126/300 (42%), Gaps = 44/300 (14%)
Query: 13 IPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFL--SLLLAGLLTGLA--- 67
+ K +GL + + I+ ANLL+ + I +RR P ++L +L A GLA
Sbjct: 48 VSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFP---IYYLMANLAAADFFAGLAYFY 104
Query: 68 --LPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLR-PLQPPGSI 124
T P N R + LL + S + +ANLL + ER++ V R L S
Sbjct: 105 LMFNTGP---NTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSN 161
Query: 125 R---LALLLTWAGPLLFASLPALGWNHWTPGANCSSQA-IFPAPYL-YLEVYGLLLPAVG 179
R + +++ W ++ ++P++GWN NCS+ A ++ YL + ++ L+ V
Sbjct: 162 RRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVV- 220
Query: 180 AAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGP 239
L + ++ + R R+ + ++ T GA F +CW P
Sbjct: 221 -MVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKT---VVIVLGA---FIICWTP 273
Query: 240 YVATLLL-------SVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWR 292
+ LLL VLAYE+ L L ++A P+ D+ +A +R
Sbjct: 274 GLVLLLLDVCCPQCDVLAYEK----------FFLLLAEFNSAMNPIIYSYRDKEMSATFR 323
>gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens]
Length = 364
Score = 49.3 bits (116), Expect = 5e-06
Identities = 74/300 (24%), Positives = 126/300 (42%), Gaps = 44/300 (14%)
Query: 13 IPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFL--SLLLAGLLTGLA--- 67
+ K +GL + + I+ ANLL+ + I +RR P ++L +L A GLA
Sbjct: 48 VSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFP---IYYLMANLAAADFFAGLAYFY 104
Query: 68 --LPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLR-PLQPPGSI 124
T P N R + LL + S + +ANLL + ER++ V R L S
Sbjct: 105 LMFNTGP---NTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSN 161
Query: 125 R---LALLLTWAGPLLFASLPALGWNHWTPGANCSSQA-IFPAPYL-YLEVYGLLLPAVG 179
R + +++ W ++ ++P++GWN NCS+ A ++ YL + ++ L+ V
Sbjct: 162 RRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVV- 220
Query: 180 AAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGP 239
L + ++ + R R+ + ++ T GA F +CW P
Sbjct: 221 -MVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKT---VVIVLGA---FIICWTP 273
Query: 240 YVATLLL-------SVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWR 292
+ LLL VLAYE+ L L ++A P+ D+ +A +R
Sbjct: 274 GLVLLLLDVCCPQCDVLAYEK----------FFLLLAEFNSAMNPIIYSYRDKEMSATFR 323
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 48.5 bits (114), Expect = 8e-06
Identities = 74/280 (26%), Positives = 111/280 (39%), Gaps = 41/280 (14%)
Query: 2 TPNST---GEVPSPIPKGALGLSLALA---SLIITANLLLALGIAWDRRLRSPPAGCFFL 55
T NST G P P G+ ++ AL +L AN LL I LR+ + F +
Sbjct: 8 TANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT-SNFFLV 66
Query: 56 SLLLAGLLTGLALPTLPGLWNQSRRGYWS-----CLLVYLAPNFSFLSLLANLLLVHGER 110
SL + L+ GL + +P + G W CLL + + NL L+ +R
Sbjct: 67 SLFTSDLMVGLVV--MPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDR 124
Query: 111 YMAVLRPLQ-----PPGSIRLALLLTWAGPLLFASLP-ALGWN---HWTPGANCSSQAIF 161
Y+ +L PL+ P +L W+ L + LP LGW+ H P + +
Sbjct: 125 YLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLA 184
Query: 162 PAPYLYLEVYGL--LLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDE--------- 210
P++ L GL LP+ GA F R+L A +Q + L +
Sbjct: 185 SLPFV-LVASGLTFFLPS-GAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRT 242
Query: 211 -----PSALARALTWRQARAQAGAMLLFGLCWGPYVATLL 245
SA +R L + +R A L G+ G + T L
Sbjct: 243 PRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWL 282
>gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 48.1 bits (113), Expect = 1e-05
Identities = 71/288 (24%), Positives = 121/288 (42%), Gaps = 23/288 (7%)
Query: 20 LSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLL-TGLALPTLPGLWNQS 78
LSL L + + NLL+ I R LR P+ F SL +A LL + + + +
Sbjct: 122 LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFH 181
Query: 79 RRGYWSCLLVYL-APNFSFLSLLANLLLVHGERYMAVLRPL------QPPGSIRLALLLT 131
R+ + L L SF + + +L L +RY+++ RPL P ++ +A L
Sbjct: 182 RKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAV-VAFCLM 240
Query: 132 WAGPLLFASLPALGWNHWTPGANCSSQAIFP---APYLYLEV---YGLLLPAVGAAAFLS 185
W ++ A LP LGWN + CS IFP YL + LLL V A ++
Sbjct: 241 WTIAIVIAVLPLLGWNCEKLQSVCSD--IFPHIDETYLMFWIGVTSVLLLFIVYAYMYIL 298
Query: 186 VRVLATAHRQLQDICRLERAVCRDEPSAL------ARALTWRQARAQAGAMLLFGLCWGP 239
+ + A R +Q + + E + + R A+ +++ +CWGP
Sbjct: 299 WKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGP 358
Query: 240 YVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRY 287
+A ++ V + S+L L +++ + A+ D R+
Sbjct: 359 LLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRH 406
>gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 48.1 bits (113), Expect = 1e-05
Identities = 71/288 (24%), Positives = 121/288 (42%), Gaps = 23/288 (7%)
Query: 20 LSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLL-TGLALPTLPGLWNQS 78
LSL L + + NLL+ I R LR P+ F SL +A LL + + + +
Sbjct: 122 LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFH 181
Query: 79 RRGYWSCLLVYL-APNFSFLSLLANLLLVHGERYMAVLRPL------QPPGSIRLALLLT 131
R+ + L L SF + + +L L +RY+++ RPL P ++ +A L
Sbjct: 182 RKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAV-VAFCLM 240
Query: 132 WAGPLLFASLPALGWNHWTPGANCSSQAIFP---APYLYLEV---YGLLLPAVGAAAFLS 185
W ++ A LP LGWN + CS IFP YL + LLL V A ++
Sbjct: 241 WTIAIVIAVLPLLGWNCEKLQSVCSD--IFPHIDETYLMFWIGVTSVLLLFIVYAYMYIL 298
Query: 186 VRVLATAHRQLQDICRLERAVCRDEPSAL------ARALTWRQARAQAGAMLLFGLCWGP 239
+ + A R +Q + + E + + R A+ +++ +CWGP
Sbjct: 299 WKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGP 358
Query: 240 YVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRY 287
+A ++ V + S+L L +++ + A+ D R+
Sbjct: 359 LLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRH 406
>gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 48.1 bits (113), Expect = 1e-05
Identities = 71/288 (24%), Positives = 121/288 (42%), Gaps = 23/288 (7%)
Query: 20 LSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLL-TGLALPTLPGLWNQS 78
LSL L + + NLL+ I R LR P+ F SL +A LL + + + +
Sbjct: 122 LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFH 181
Query: 79 RRGYWSCLLVYL-APNFSFLSLLANLLLVHGERYMAVLRPL------QPPGSIRLALLLT 131
R+ + L L SF + + +L L +RY+++ RPL P ++ +A L
Sbjct: 182 RKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAV-VAFCLM 240
Query: 132 WAGPLLFASLPALGWNHWTPGANCSSQAIFP---APYLYLEV---YGLLLPAVGAAAFLS 185
W ++ A LP LGWN + CS IFP YL + LLL V A ++
Sbjct: 241 WTIAIVIAVLPLLGWNCEKLQSVCSD--IFPHIDETYLMFWIGVTSVLLLFIVYAYMYIL 298
Query: 186 VRVLATAHRQLQDICRLERAVCRDEPSAL------ARALTWRQARAQAGAMLLFGLCWGP 239
+ + A R +Q + + E + + R A+ +++ +CWGP
Sbjct: 299 WKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGP 358
Query: 240 YVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRY 287
+A ++ V + S+L L +++ + A+ D R+
Sbjct: 359 LLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRH 406
>gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 48.1 bits (113), Expect = 1e-05
Identities = 71/288 (24%), Positives = 121/288 (42%), Gaps = 23/288 (7%)
Query: 20 LSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLL-TGLALPTLPGLWNQS 78
LSL L + + NLL+ I R LR P+ F SL +A LL + + + +
Sbjct: 122 LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFH 181
Query: 79 RRGYWSCLLVYL-APNFSFLSLLANLLLVHGERYMAVLRPL------QPPGSIRLALLLT 131
R+ + L L SF + + +L L +RY+++ RPL P ++ +A L
Sbjct: 182 RKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAV-VAFCLM 240
Query: 132 WAGPLLFASLPALGWNHWTPGANCSSQAIFP---APYLYLEV---YGLLLPAVGAAAFLS 185
W ++ A LP LGWN + CS IFP YL + LLL V A ++
Sbjct: 241 WTIAIVIAVLPLLGWNCEKLQSVCSD--IFPHIDETYLMFWIGVTSVLLLFIVYAYMYIL 298
Query: 186 VRVLATAHRQLQDICRLERAVCRDEPSAL------ARALTWRQARAQAGAMLLFGLCWGP 239
+ + A R +Q + + E + + R A+ +++ +CWGP
Sbjct: 299 WKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGP 358
Query: 240 YVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRY 287
+A ++ V + S+L L +++ + A+ D R+
Sbjct: 359 LLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRH 406
>gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 48.1 bits (113), Expect = 1e-05
Identities = 71/288 (24%), Positives = 121/288 (42%), Gaps = 23/288 (7%)
Query: 20 LSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLL-TGLALPTLPGLWNQS 78
LSL L + + NLL+ I R LR P+ F SL +A LL + + + +
Sbjct: 122 LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFH 181
Query: 79 RRGYWSCLLVYL-APNFSFLSLLANLLLVHGERYMAVLRPL------QPPGSIRLALLLT 131
R+ + L L SF + + +L L +RY+++ RPL P ++ +A L
Sbjct: 182 RKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAV-VAFCLM 240
Query: 132 WAGPLLFASLPALGWNHWTPGANCSSQAIFP---APYLYLEV---YGLLLPAVGAAAFLS 185
W ++ A LP LGWN + CS IFP YL + LLL V A ++
Sbjct: 241 WTIAIVIAVLPLLGWNCEKLQSVCSD--IFPHIDETYLMFWIGVTSVLLLFIVYAYMYIL 298
Query: 186 VRVLATAHRQLQDICRLERAVCRDEPSAL------ARALTWRQARAQAGAMLLFGLCWGP 239
+ + A R +Q + + E + + R A+ +++ +CWGP
Sbjct: 299 WKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGP 358
Query: 240 YVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRY 287
+A ++ V + S+L L +++ + A+ D R+
Sbjct: 359 LLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRH 406
>gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens]
Length = 382
Score = 48.1 bits (113), Expect = 1e-05
Identities = 66/236 (27%), Positives = 102/236 (43%), Gaps = 17/236 (7%)
Query: 22 LALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRG 81
+ + II N+ + L I W + P F +L L+ LL G+A T L + +
Sbjct: 53 ILICCFIILENIFVLLTI-WKTKKFHRPMYYFIGNLALSDLLAGVAY-TANLLLSGATTY 110
Query: 82 YWSCLLVYLAPNFSFLSLLAN---LLLVHGERYMAVLRPLQPPGS--IRLALLLT--WAG 134
+ +L F++L A+ LL + ERY+ +L+ GS RL LL++ W
Sbjct: 111 KLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVI 170
Query: 135 PLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHR 194
L+ LP +GWN + ++CS+ + P LY + Y L V LS+ +L
Sbjct: 171 SLILGGLPIMGWNCISALSSCST--VLP---LYHKHYILFCTTVFTLLLLSIVILYCRIY 225
Query: 195 QLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLL--FGLCWGPYVATLLLSV 248
L R R R S +R+ A + ++L F CW P LLL V
Sbjct: 226 SLVR-TRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDV 280
>gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens]
Length = 439
Score = 48.1 bits (113), Expect = 1e-05
Identities = 71/288 (24%), Positives = 121/288 (42%), Gaps = 23/288 (7%)
Query: 20 LSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLL-TGLALPTLPGLWNQS 78
LSL L + + NLL+ I R LR P+ F SL +A LL + + + +
Sbjct: 89 LSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFH 148
Query: 79 RRGYWSCLLVYL-APNFSFLSLLANLLLVHGERYMAVLRPL------QPPGSIRLALLLT 131
R+ + L L SF + + +L L +RY+++ RPL P ++ +A L
Sbjct: 149 RKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAV-VAFCLM 207
Query: 132 WAGPLLFASLPALGWNHWTPGANCSSQAIFP---APYLYLEV---YGLLLPAVGAAAFLS 185
W ++ A LP LGWN + CS IFP YL + LLL V A ++
Sbjct: 208 WTIAIVIAVLPLLGWNCEKLQSVCSD--IFPHIDETYLMFWIGVTSVLLLFIVYAYMYIL 265
Query: 186 VRVLATAHRQLQDICRLERAVCRDEPSAL------ARALTWRQARAQAGAMLLFGLCWGP 239
+ + A R +Q + + E + + R A+ +++ +CWGP
Sbjct: 266 WKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGP 325
Query: 240 YVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRY 287
+A ++ V + S+L L +++ + A+ D R+
Sbjct: 326 LLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRH 373
>gi|36951034 G protein-coupled receptor 78 [Homo sapiens]
Length = 363
Score = 47.8 bits (112), Expect = 1e-05
Identities = 67/260 (25%), Positives = 114/260 (43%), Gaps = 28/260 (10%)
Query: 19 GLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLL-TGLALP-TLPGLWN 76
GL + + ++ + +N L+ L A+ LR+ +G ++L L LL L +P TL G+
Sbjct: 10 GLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLVNLSLGHLLLAALDMPFTLLGVMR 69
Query: 77 -QSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIR-----LALLL 130
++ +C ++ F + ++ + ++++AV PL+ G +R L L
Sbjct: 70 GRTPSAPGACQVIGFLDTFLASNAALSVAALSADQWLAVGFPLRYAGRLRPRYAGLLLGC 129
Query: 131 TWAGPLLFASLPALG--WNHWTPG-ANCS-------SQAIFPAPYLYLEVYGLLLP-AVG 179
W L F+ ALG W ++ A+CS + F A L G +LP AV
Sbjct: 130 AWGQSLAFSGA-ALGCSWLGYSSAFASCSLRLPPEPERPRFAAFTATLHAVGFVLPLAVL 188
Query: 180 AAAFLSVRVLATAHRQLQDICRLER-AVCRD-EPSALARALTWRQARAQAG------AML 231
L V +A H Q D ++ A+ D PS R L ++ R A+
Sbjct: 189 CLTSLQVHRVARRHCQRMDTVTMKALALLADLHPSVRQRCLIQQKRRRHRATRKIGIAIA 248
Query: 232 LFGLCWGPYVATLLLSVLAY 251
F +C+ PYV T L ++ +
Sbjct: 249 TFLICFAPYVMTRLAELVPF 268
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 47.4 bits (111), Expect = 2e-05
Identities = 63/252 (25%), Positives = 99/252 (39%), Gaps = 40/252 (15%)
Query: 27 LIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGL------ALPTLPGLWNQSRR 80
+ I NLL+ + + WDR+LR F +SL A LL + A+ + +W
Sbjct: 32 MAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIY--- 88
Query: 81 GYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAV-LRPL---QPPGSIRLALLL--TWAG 134
G CL+ + + +L + +RY A+ +PL +R+AL+L W
Sbjct: 89 GEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVI 148
Query: 135 PLLFASLPAL-GWNH-----------WTPGANCSSQAIFPA--PY-LYLEVYGLLLPAVG 179
P + LP + GWN+ + +N S+ +F PY + V +P +
Sbjct: 149 PTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN-STYCVFMVNKPYAITCSVVAFYIPFL- 206
Query: 180 AAAFLSVRVLATAHRQLQDICRLERAVCRDE--PSALARALTWRQARAQAGAMLL----- 232
R+ TA I L+RA E P + + T R A L
Sbjct: 207 LMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMG 266
Query: 233 -FGLCWGPYVAT 243
F LCW P+ T
Sbjct: 267 CFCLCWAPFFVT 278
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 47.4 bits (111), Expect = 2e-05
Identities = 63/252 (25%), Positives = 99/252 (39%), Gaps = 40/252 (15%)
Query: 27 LIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGL------ALPTLPGLWNQSRR 80
+ I NLL+ + + WDR+LR F +SL A LL + A+ + +W
Sbjct: 32 MAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIY--- 88
Query: 81 GYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAV-LRPL---QPPGSIRLALLL--TWAG 134
G CL+ + + +L + +RY A+ +PL +R+AL+L W
Sbjct: 89 GEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVI 148
Query: 135 PLLFASLPAL-GWNH-----------WTPGANCSSQAIFPA--PY-LYLEVYGLLLPAVG 179
P + LP + GWN+ + +N S+ +F PY + V +P +
Sbjct: 149 PTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN-STYCVFMVNKPYAITCSVVAFYIPFL- 206
Query: 180 AAAFLSVRVLATAHRQLQDICRLERAVCRDE--PSALARALTWRQARAQAGAMLL----- 232
R+ TA I L+RA E P + + T R A L
Sbjct: 207 LMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMG 266
Query: 233 -FGLCWGPYVAT 243
F LCW P+ T
Sbjct: 267 CFCLCWAPFFVT 278
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 47.4 bits (111), Expect = 2e-05
Identities = 63/252 (25%), Positives = 99/252 (39%), Gaps = 40/252 (15%)
Query: 27 LIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGL------ALPTLPGLWNQSRR 80
+ I NLL+ + + WDR+LR F +SL A LL + A+ + +W
Sbjct: 32 MAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIY--- 88
Query: 81 GYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAV-LRPL---QPPGSIRLALLL--TWAG 134
G CL+ + + +L + +RY A+ +PL +R+AL+L W
Sbjct: 89 GEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVI 148
Query: 135 PLLFASLPAL-GWNH-----------WTPGANCSSQAIFPA--PY-LYLEVYGLLLPAVG 179
P + LP + GWN+ + +N S+ +F PY + V +P +
Sbjct: 149 PTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN-STYCVFMVNKPYAITCSVVAFYIPFL- 206
Query: 180 AAAFLSVRVLATAHRQLQDICRLERAVCRDE--PSALARALTWRQARAQAGAMLL----- 232
R+ TA I L+RA E P + + T R A L
Sbjct: 207 LMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMG 266
Query: 233 -FGLCWGPYVAT 243
F LCW P+ T
Sbjct: 267 CFCLCWAPFFVT 278
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 47.4 bits (111), Expect = 2e-05
Identities = 63/252 (25%), Positives = 99/252 (39%), Gaps = 40/252 (15%)
Query: 27 LIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGL------ALPTLPGLWNQSRR 80
+ I NLL+ + + WDR+LR F +SL A LL + A+ + +W
Sbjct: 32 MAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIY--- 88
Query: 81 GYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAV-LRPL---QPPGSIRLALLL--TWAG 134
G CL+ + + +L + +RY A+ +PL +R+AL+L W
Sbjct: 89 GEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVI 148
Query: 135 PLLFASLPAL-GWNH-----------WTPGANCSSQAIFPA--PY-LYLEVYGLLLPAVG 179
P + LP + GWN+ + +N S+ +F PY + V +P +
Sbjct: 149 PTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN-STYCVFMVNKPYAITCSVVAFYIPFL- 206
Query: 180 AAAFLSVRVLATAHRQLQDICRLERAVCRDE--PSALARALTWRQARAQAGAMLL----- 232
R+ TA I L+RA E P + + T R A L
Sbjct: 207 LMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMG 266
Query: 233 -FGLCWGPYVAT 243
F LCW P+ T
Sbjct: 267 CFCLCWAPFFVT 278
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 47.4 bits (111), Expect = 2e-05
Identities = 63/252 (25%), Positives = 99/252 (39%), Gaps = 40/252 (15%)
Query: 27 LIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGL------ALPTLPGLWNQSRR 80
+ I NLL+ + + WDR+LR F +SL A LL + A+ + +W
Sbjct: 32 MAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIY--- 88
Query: 81 GYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAV-LRPL---QPPGSIRLALLL--TWAG 134
G CL+ + + +L + +RY A+ +PL +R+AL+L W
Sbjct: 89 GEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVI 148
Query: 135 PLLFASLPAL-GWNH-----------WTPGANCSSQAIFPA--PY-LYLEVYGLLLPAVG 179
P + LP + GWN+ + +N S+ +F PY + V +P +
Sbjct: 149 PTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN-STYCVFMVNKPYAITCSVVAFYIPFL- 206
Query: 180 AAAFLSVRVLATAHRQLQDICRLERAVCRDE--PSALARALTWRQARAQAGAMLL----- 232
R+ TA I L+RA E P + + T R A L
Sbjct: 207 LMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMG 266
Query: 233 -FGLCWGPYVAT 243
F LCW P+ T
Sbjct: 267 CFCLCWAPFFVT 278
>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
Length = 388
Score = 47.4 bits (111), Expect = 2e-05
Identities = 63/252 (25%), Positives = 99/252 (39%), Gaps = 40/252 (15%)
Query: 27 LIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGL------ALPTLPGLWNQSRR 80
+ I NLL+ + + WDR+LR F +SL A LL + A+ + +W
Sbjct: 32 MAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIY--- 88
Query: 81 GYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAV-LRPL---QPPGSIRLALLL--TWAG 134
G CL+ + + +L + +RY A+ +PL +R+AL+L W
Sbjct: 89 GEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVI 148
Query: 135 PLLFASLPAL-GWNH-----------WTPGANCSSQAIFPA--PY-LYLEVYGLLLPAVG 179
P + LP + GWN+ + +N S+ +F PY + V +P +
Sbjct: 149 PTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN-STYCVFMVNKPYAITCSVVAFYIPFL- 206
Query: 180 AAAFLSVRVLATAHRQLQDICRLERAVCRDE--PSALARALTWRQARAQAGAMLL----- 232
R+ TA I L+RA E P + + T R A L
Sbjct: 207 LMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMG 266
Query: 233 -FGLCWGPYVAT 243
F LCW P+ T
Sbjct: 267 CFCLCWAPFFVT 278
>gi|4557865 somatostatin receptor 5 [Homo sapiens]
Length = 364
Score = 45.4 bits (106), Expect = 7e-05
Identities = 64/272 (23%), Positives = 108/272 (39%), Gaps = 25/272 (9%)
Query: 53 FFLSLLLAGLLTGLALPTLPGLWNQSRRGYWS-----CLLVYLAPNFSFLSLLANLLLVH 107
+ L+L +A +L L LP L Q+ +W C LV + + + L ++
Sbjct: 78 YILNLAVADVLYMLGLPFLA---TQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMS 134
Query: 108 GERYMAVLRPLQP-----PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFP 162
+RY+AV+ PL P +LA W L SLP L + G C+ A +P
Sbjct: 135 VDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCM-SLPLLVFADVQEGGTCN--ASWP 191
Query: 163 APY-LYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWR 221
P L+ V+ + +G A L V L L + ++ A R + R +
Sbjct: 192 EPVGLWGAVFIIYTAVLGFFAPLLVICLC----YLLIVVKVRAAGVR--VGCVRRRSERK 245
Query: 222 QARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMG 281
R +L+F CW P+ ++++ + P G ++ L A++ A PV G
Sbjct: 246 VTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYG 305
Query: 282 LGDQRYTAPWRAAAQRCLQGLWGRASRDSPGP 313
+ ++ CL+ G D+ P
Sbjct: 306 FLSDNFRQSFQKVL--CLRKGSGAKDADATEP 335
>gi|9789897 leukotriene B4 receptor 2 [Homo sapiens]
Length = 389
Score = 45.4 bits (106), Expect = 7e-05
Identities = 80/273 (29%), Positives = 102/273 (37%), Gaps = 49/273 (17%)
Query: 22 LALASLI-ITANLLLALGIAWDRRLRSPP-AGCFFLSLLLAG----LLTGLALPTLPG-L 74
L LA+L+ + N + +A R R P A L L LA LLT L + L
Sbjct: 58 LLLAALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQA 117
Query: 75 WNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRP-----LQPPGSIRLALL 129
W + G C VY S + + L+ +R +AV RP L+ P R LL
Sbjct: 118 WPLGQAG---CKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLL 174
Query: 130 LTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVL 189
W LL A +PA + H C Q P+P V AAA LS+ L
Sbjct: 175 AVWLAALLLA-VPAAVYRHLWRDRVC--QLCHPSP-------------VHAAAHLSLETL 218
Query: 190 ATAHRQLQDICRLERAVCRDEPSALARALTW-------RQARAQAGAMLLFGLCWGPYVA 242
+ C A R W R R + +L FGL W PY A
Sbjct: 219 TAFVLPFGLMLG-----CYSVTLARLRGARWGSGRHGARVGRLVSAIVLAFGLLWAPYHA 273
Query: 243 TLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAA 275
LL +A PP G +L LG A AA
Sbjct: 274 VNLLQAVA-ALAPPEG-----ALAKLGGAGQAA 300
>gi|223633986 trace amine associated receptor 5 [Homo sapiens]
Length = 337
Score = 45.4 bits (106), Expect = 7e-05
Identities = 58/247 (23%), Positives = 104/247 (42%), Gaps = 24/247 (9%)
Query: 27 LIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLA---LPTLPGLWNQSRRGYW 83
+I+ N+ +A +++ + L +P LSL LA + GL L T+ + + G +
Sbjct: 47 IIVLGNVFVAFAVSYFKALHTP-TNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDF 105
Query: 84 SCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPG--SIRLAL---LLTWAGPLLF 138
C L L+ + +L + +R+ A+ PL P ++R+AL L W P +
Sbjct: 106 LCRLHTYLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAY 165
Query: 139 ASL------PALGWNHWTPGANC--SSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLA 190
SL + W C S Q + + +L +P + + L V++
Sbjct: 166 TSLFLYTDVVETRLSQWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMIS-LYVKIFV 224
Query: 191 TAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLA 250
A RQ Q I L +++ A A + A+ A+ ++ LCW P+ ++ L
Sbjct: 225 VATRQAQQITTLSKSL------AGAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLL 278
Query: 251 YEQRPPL 257
+ PPL
Sbjct: 279 HFITPPL 285
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 45.1 bits (105), Expect = 9e-05
Identities = 46/152 (30%), Positives = 67/152 (44%), Gaps = 24/152 (15%)
Query: 17 ALGLSLALASLIITA---NLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPG 73
A+ + L L + I+ A N+L+ L +A +R LR+ P F ++L +A LL L+ LP
Sbjct: 45 AISVGLVLGAFILFAIVGNILVILSVACNRHLRT-PTNYFIVNLAMADLL--LSFTVLPF 101
Query: 74 LWNQSRRGYWSCLLVY---------LAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSI 124
GYW ++ L S LSL A + +RY+ V LQ P +
Sbjct: 102 SAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCA----ISIDRYIGVRYSLQYPTLV 157
Query: 125 R-----LALLLTWAGPLLFASLPALGWNHWTP 151
LALL W + + P LGW P
Sbjct: 158 TRRKAILALLSVWVLSTVISIGPLLGWKEPAP 189
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,775,097
Number of Sequences: 37866
Number of extensions: 622454
Number of successful extensions: 1933
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 140
Number of HSP's that attempted gapping in prelim test: 1848
Number of HSP's gapped (non-prelim): 181
length of query: 330
length of database: 18,247,518
effective HSP length: 103
effective length of query: 227
effective length of database: 14,347,320
effective search space: 3256841640
effective search space used: 3256841640
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.