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Search of human proteins with 116256485
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116256485 chromosome 6 open reading frame 10 [Homo sapiens]
(563 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116256485 chromosome 6 open reading frame 10 [Homo sapiens] 1088 0.0
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap... 81 3e-15
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap... 81 3e-15
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi... 81 3e-15
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 74 3e-13
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 74 3e-13
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 73 6e-13
gi|125656165 THO complex 2 [Homo sapiens] 67 6e-11
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 67 6e-11
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 64 3e-10
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 63 6e-10
gi|4557509 cylicin 2 [Homo sapiens] 60 4e-09
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 60 4e-09
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 59 9e-09
gi|104526627 triadin [Homo sapiens] 59 9e-09
gi|44890059 involucrin [Homo sapiens] 59 1e-08
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 57 5e-08
gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform... 56 8e-08
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 55 2e-07
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 55 2e-07
gi|190014588 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo... 55 2e-07
gi|19923653 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo ... 55 2e-07
gi|150378549 tangerin [Homo sapiens] 54 5e-07
gi|190014586 PC4 and SFRS1 interacting protein 1 isoform 1 [Homo... 53 7e-07
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)... 53 7e-07
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)... 53 7e-07
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)... 53 7e-07
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex... 53 7e-07
gi|217330641 IWS1 homolog [Homo sapiens] 53 8e-07
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 52 1e-06
>gi|116256485 chromosome 6 open reading frame 10 [Homo sapiens]
Length = 563
Score = 1088 bits (2815), Expect = 0.0
Identities = 563/563 (100%), Positives = 563/563 (100%)
Query: 1 MTVLEITLAVILTLLGLAILAILLTRWARCKQSEMYISRYSSEQSARLLDYEDGRGSRHA 60
MTVLEITLAVILTLLGLAILAILLTRWARCKQSEMYISRYSSEQSARLLDYEDGRGSRHA
Sbjct: 1 MTVLEITLAVILTLLGLAILAILLTRWARCKQSEMYISRYSSEQSARLLDYEDGRGSRHA 60
Query: 61 YSTQSDTSYDNRERSKRDYTPSTNSLVSMASKFSLGQTELILLLMCFILALSRSSIGSIK 120
YSTQSDTSYDNRERSKRDYTPSTNSLVSMASKFSLGQTELILLLMCFILALSRSSIGSIK
Sbjct: 61 YSTQSDTSYDNRERSKRDYTPSTNSLVSMASKFSLGQTELILLLMCFILALSRSSIGSIK 120
Query: 121 CLQTTEEPPSRTAGAMMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYPGSNAGPPSAPRG 180
CLQTTEEPPSRTAGAMMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYPGSNAGPPSAPRG
Sbjct: 121 CLQTTEEPPSRTAGAMMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYPGSNAGPPSAPRG 180
Query: 181 PPMAPIIISQRTARIPQVHTMDSSGKITLTPVVILTGYMDEELAKKSCSKIQILKCGGTA 240
PPMAPIIISQRTARIPQVHTMDSSGKITLTPVVILTGYMDEELAKKSCSKIQILKCGGTA
Sbjct: 181 PPMAPIIISQRTARIPQVHTMDSSGKITLTPVVILTGYMDEELAKKSCSKIQILKCGGTA 240
Query: 241 RSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGI 300
RSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGI
Sbjct: 241 RSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGI 300
Query: 301 PKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVV 360
PKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVV
Sbjct: 301 PKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVV 360
Query: 361 LKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKV 420
LKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKV
Sbjct: 361 LKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKV 420
Query: 421 PKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGV 480
PKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGV
Sbjct: 421 PKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGV 480
Query: 481 LKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEING 540
LKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEING
Sbjct: 481 LKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEING 540
Query: 541 EKSKGSKRAKANTGRKYNKKVEE 563
EKSKGSKRAKANTGRKYNKKVEE
Sbjct: 541 EKSKGSKRAKANTGRKYNKKVEE 563
>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 80.9 bits (198), Expect = 3e-15
Identities = 59/267 (22%), Positives = 112/267 (41%), Gaps = 8/267 (2%)
Query: 300 IPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLV 359
+PK E ++ E +IP+ I+ + ++P+ + E +PK E +
Sbjct: 67 LPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKED 126
Query: 360 VLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELK 419
+ K E ++ E +P+ ++ ++K + +ES + K E ++ E
Sbjct: 127 LPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGD 186
Query: 420 VPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESG 479
+PK ++ ++PK + E + K PE ++ E +P++LE ++ E
Sbjct: 187 IPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGD 246
Query: 480 VLKG-QEAQEKKESFEDKGNND--KEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRES 536
+ K +EA + KE K + + KE D K P E+ + KGD K + +
Sbjct: 247 IPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSP---EETIQPKKGDIPKSPEEAIQPK 303
Query: 537 EINGEKSKGSKRAKANTGRKYNKKVEE 563
E G+ K K+A K +EE
Sbjct: 304 E--GDIPKSPKQAIQPKEGDIPKSLEE 328
Score = 76.3 bits (186), Expect = 7e-14
Identities = 44/214 (20%), Positives = 88/214 (41%), Gaps = 15/214 (7%)
Query: 287 KIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQ------------ 334
K ++ ++ IPK E ++ E IP+ I+ + ++P+
Sbjct: 159 KTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIS 218
Query: 335 ---ESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVS 391
E ++ E +PK E + + K E ++ E +P+ E ++ + +
Sbjct: 219 KSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIP 278
Query: 392 KGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVL 451
K E ++ ++ + K E ++ E +PK + ++ E D+PK E E +
Sbjct: 279 KSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIP 338
Query: 452 KGPESQVKNTEVSVPETLESQVKKSESGVLKGQE 485
K PE ++ E P++LE E +LK +E
Sbjct: 339 KSPEETIQPKEDDSPKSLEEATPSKEGDILKPEE 372
Score = 70.5 bits (171), Expect = 4e-12
Identities = 46/242 (19%), Positives = 99/242 (40%), Gaps = 19/242 (7%)
Query: 300 IPKRQETQLKISEMSIPQGQGAQIKKSV---------------SDVPRGQESQVKKSESG 344
+PK E ++ E IP+ I+ + SD+P+ E ++ E
Sbjct: 127 LPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGD 186
Query: 345 VPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESV 404
+PK + + K + E + + E ++ + + K E ++ +E
Sbjct: 187 IPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGD 246
Query: 405 VLKGQEAQVEKSELKVPKGQEGQVEKTEADVPK--EQEVQEKKSEAGVLKGPESQVKNTE 462
+ K E ++ E +PK E ++ E D+PK E+ +Q KK + + K PE ++ E
Sbjct: 247 IPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGD--IPKSPEEAIQPKE 304
Query: 463 VSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTK 522
+P++ + ++ E + K E + + + ++ + + P E+ + +
Sbjct: 305 GDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKE 364
Query: 523 GD 524
GD
Sbjct: 365 GD 366
Score = 69.7 bits (169), Expect = 7e-12
Identities = 52/260 (20%), Positives = 110/260 (42%), Gaps = 18/260 (6%)
Query: 272 KEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVP 331
K PE + + K + ++ IPK ++ +IP+ + D+P
Sbjct: 54 KAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIP 113
Query: 332 RGQESQVKKSESGVPKG-------QEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVK 384
+ E ++ + +PK +E + KS ++ + + K+ + + +ES +
Sbjct: 114 KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP 173
Query: 385 KSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKT--------EADVP 436
KS + +E + K + ++ + + K+ +K + +EG + K+ E D+P
Sbjct: 174 KSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLP 233
Query: 437 KEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKG-QEAQEKKESFED 495
K E + E + K PE ++ E +P++LE ++ E + K +E + K+
Sbjct: 234 KSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIP 293
Query: 496 KGNND--KEKERDAEKDPNK 513
K + + KE D K P +
Sbjct: 294 KSPEEAIQPKEGDIPKSPKQ 313
Score = 67.0 bits (162), Expect = 4e-11
Identities = 36/176 (20%), Positives = 73/176 (41%)
Query: 287 KIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVP 346
K ++ + I K E ++ E +P+ I+ D+P+ E ++ E +P
Sbjct: 204 KASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIP 263
Query: 347 KGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVL 406
K E + + K E ++ + +P+ E ++ + + K + ++ +E +
Sbjct: 264 KSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIP 323
Query: 407 KGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTE 462
K E + E+ +PK E ++ E D PK E E +LK E ++ E
Sbjct: 324 KSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPE 379
Score = 52.8 bits (125), Expect = 8e-07
Identities = 38/182 (20%), Positives = 72/182 (39%), Gaps = 4/182 (2%)
Query: 272 KEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVP 331
K PE + + + K E + IPK E ++ E IP+ I+ D+P
Sbjct: 219 KSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIP 278
Query: 332 RGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVS 391
+ E ++ + +PK E + + K + ++ E +P+ E + + +
Sbjct: 279 KSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIP 338
Query: 392 KGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPK----EQEVQEKKSE 447
K E ++ +E K E E + K +E +E E D K +++ + E
Sbjct: 339 KSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKE 398
Query: 448 AG 449
AG
Sbjct: 399 AG 400
Score = 42.7 bits (99), Expect = 9e-04
Identities = 33/187 (17%), Positives = 75/187 (40%), Gaps = 17/187 (9%)
Query: 361 LKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKV 420
++ +E+ + +P+ + Q K E ++ +E + K E ++ + +
Sbjct: 8 MRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDL 67
Query: 421 PKGQEGQVEKTEADVPKE--QEVQEK-------------KSEAGVLKGPESQVKNTEVSV 465
PK E ++ E+++PK + +Q K E + K PE +++ + +
Sbjct: 68 PKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDL 127
Query: 466 PETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKD-PNKKEKGDKNTKGD 524
P++ E ++ E + K A+ + + + + E D P E+ + +GD
Sbjct: 128 PKSSEEAIQPKEGDIPK-SSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGD 186
Query: 525 KGKDKVK 531
K K
Sbjct: 187 IPKSSAK 193
>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
sapiens]
Length = 553
Score = 80.9 bits (198), Expect = 3e-15
Identities = 59/267 (22%), Positives = 112/267 (41%), Gaps = 8/267 (2%)
Query: 300 IPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLV 359
+PK E ++ E +IP+ I+ + ++P+ + E +PK E +
Sbjct: 134 LPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKED 193
Query: 360 VLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELK 419
+ K E ++ E +P+ ++ ++K + +ES + K E ++ E
Sbjct: 194 LPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGD 253
Query: 420 VPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESG 479
+PK ++ ++PK + E + K PE ++ E +P++LE ++ E
Sbjct: 254 IPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGD 313
Query: 480 VLKG-QEAQEKKESFEDKGNND--KEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRES 536
+ K +EA + KE K + + KE D K P E+ + KGD K + +
Sbjct: 314 IPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSP---EETIQPKKGDIPKSPEEAIQPK 370
Query: 537 EINGEKSKGSKRAKANTGRKYNKKVEE 563
E G+ K K+A K +EE
Sbjct: 371 E--GDIPKSPKQAIQPKEGDIPKSLEE 395
Score = 76.3 bits (186), Expect = 7e-14
Identities = 44/214 (20%), Positives = 88/214 (41%), Gaps = 15/214 (7%)
Query: 287 KIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQ------------ 334
K ++ ++ IPK E ++ E IP+ I+ + ++P+
Sbjct: 226 KTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIS 285
Query: 335 ---ESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVS 391
E ++ E +PK E + + K E ++ E +P+ E ++ + +
Sbjct: 286 KSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIP 345
Query: 392 KGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVL 451
K E ++ ++ + K E ++ E +PK + ++ E D+PK E E +
Sbjct: 346 KSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIP 405
Query: 452 KGPESQVKNTEVSVPETLESQVKKSESGVLKGQE 485
K PE ++ E P++LE E +LK +E
Sbjct: 406 KSPEETIQPKEDDSPKSLEEATPSKEGDILKPEE 439
Score = 70.5 bits (171), Expect = 4e-12
Identities = 46/242 (19%), Positives = 99/242 (40%), Gaps = 19/242 (7%)
Query: 300 IPKRQETQLKISEMSIPQGQGAQIKKSV---------------SDVPRGQESQVKKSESG 344
+PK E ++ E IP+ I+ + SD+P+ E ++ E
Sbjct: 194 LPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGD 253
Query: 345 VPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESV 404
+PK + + K + E + + E ++ + + K E ++ +E
Sbjct: 254 IPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGD 313
Query: 405 VLKGQEAQVEKSELKVPKGQEGQVEKTEADVPK--EQEVQEKKSEAGVLKGPESQVKNTE 462
+ K E ++ E +PK E ++ E D+PK E+ +Q KK + + K PE ++ E
Sbjct: 314 IPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGD--IPKSPEEAIQPKE 371
Query: 463 VSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTK 522
+P++ + ++ E + K E + + + ++ + + P E+ + +
Sbjct: 372 GDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKE 431
Query: 523 GD 524
GD
Sbjct: 432 GD 433
Score = 69.7 bits (169), Expect = 7e-12
Identities = 52/260 (20%), Positives = 110/260 (42%), Gaps = 18/260 (6%)
Query: 272 KEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVP 331
K PE + + K + ++ IPK ++ +IP+ + D+P
Sbjct: 121 KAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIP 180
Query: 332 RGQESQVKKSESGVPKG-------QEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVK 384
+ E ++ + +PK +E + KS ++ + + K+ + + +ES +
Sbjct: 181 KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP 240
Query: 385 KSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKT--------EADVP 436
KS + +E + K + ++ + + K+ +K + +EG + K+ E D+P
Sbjct: 241 KSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLP 300
Query: 437 KEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKG-QEAQEKKESFED 495
K E + E + K PE ++ E +P++LE ++ E + K +E + K+
Sbjct: 301 KSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIP 360
Query: 496 KGNND--KEKERDAEKDPNK 513
K + + KE D K P +
Sbjct: 361 KSPEEAIQPKEGDIPKSPKQ 380
Score = 67.0 bits (162), Expect = 4e-11
Identities = 36/176 (20%), Positives = 73/176 (41%)
Query: 287 KIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVP 346
K ++ + I K E ++ E +P+ I+ D+P+ E ++ E +P
Sbjct: 271 KASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIP 330
Query: 347 KGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVL 406
K E + + K E ++ + +P+ E ++ + + K + ++ +E +
Sbjct: 331 KSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIP 390
Query: 407 KGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTE 462
K E + E+ +PK E ++ E D PK E E +LK E ++ E
Sbjct: 391 KSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPE 446
Score = 52.8 bits (125), Expect = 8e-07
Identities = 38/182 (20%), Positives = 72/182 (39%), Gaps = 4/182 (2%)
Query: 272 KEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVP 331
K PE + + + K E + IPK E ++ E IP+ I+ D+P
Sbjct: 286 KSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIP 345
Query: 332 RGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVS 391
+ E ++ + +PK E + + K + ++ E +P+ E + + +
Sbjct: 346 KSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIP 405
Query: 392 KGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPK----EQEVQEKKSE 447
K E ++ +E K E E + K +E +E E D K +++ + E
Sbjct: 406 KSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKE 465
Query: 448 AG 449
AG
Sbjct: 466 AG 467
Score = 42.7 bits (99), Expect = 9e-04
Identities = 33/187 (17%), Positives = 75/187 (40%), Gaps = 17/187 (9%)
Query: 361 LKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKV 420
++ +E+ + +P+ + Q K E ++ +E + K E ++ + +
Sbjct: 75 MRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDL 134
Query: 421 PKGQEGQVEKTEADVPKE--QEVQEK-------------KSEAGVLKGPESQVKNTEVSV 465
PK E ++ E+++PK + +Q K E + K PE +++ + +
Sbjct: 135 PKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDL 194
Query: 466 PETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKD-PNKKEKGDKNTKGD 524
P++ E ++ E + K A+ + + + + E D P E+ + +GD
Sbjct: 195 PKSSEEAIQPKEGDIPK-SSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGD 253
Query: 525 KGKDKVK 531
K K
Sbjct: 254 IPKSSAK 260
>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 80.9 bits (198), Expect = 3e-15
Identities = 59/267 (22%), Positives = 112/267 (41%), Gaps = 8/267 (2%)
Query: 300 IPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLV 359
+PK E ++ E +IP+ I+ + ++P+ + E +PK E +
Sbjct: 67 LPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKED 126
Query: 360 VLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELK 419
+ K E ++ E +P+ ++ ++K + +ES + K E ++ E
Sbjct: 127 LPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGD 186
Query: 420 VPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESG 479
+PK ++ ++PK + E + K PE ++ E +P++LE ++ E
Sbjct: 187 IPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGD 246
Query: 480 VLKG-QEAQEKKESFEDKGNND--KEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRES 536
+ K +EA + KE K + + KE D K P E+ + KGD K + +
Sbjct: 247 IPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSP---EETIQPKKGDIPKSPEEAIQPK 303
Query: 537 EINGEKSKGSKRAKANTGRKYNKKVEE 563
E G+ K K+A K +EE
Sbjct: 304 E--GDIPKSPKQAIQPKEGDIPKSLEE 328
Score = 76.3 bits (186), Expect = 7e-14
Identities = 44/214 (20%), Positives = 88/214 (41%), Gaps = 15/214 (7%)
Query: 287 KIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQ------------ 334
K ++ ++ IPK E ++ E IP+ I+ + ++P+
Sbjct: 159 KTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIS 218
Query: 335 ---ESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVS 391
E ++ E +PK E + + K E ++ E +P+ E ++ + +
Sbjct: 219 KSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIP 278
Query: 392 KGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVL 451
K E ++ ++ + K E ++ E +PK + ++ E D+PK E E +
Sbjct: 279 KSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIP 338
Query: 452 KGPESQVKNTEVSVPETLESQVKKSESGVLKGQE 485
K PE ++ E P++LE E +LK +E
Sbjct: 339 KSPEETIQPKEDDSPKSLEEATPSKEGDILKPEE 372
Score = 70.5 bits (171), Expect = 4e-12
Identities = 46/242 (19%), Positives = 99/242 (40%), Gaps = 19/242 (7%)
Query: 300 IPKRQETQLKISEMSIPQGQGAQIKKSV---------------SDVPRGQESQVKKSESG 344
+PK E ++ E IP+ I+ + SD+P+ E ++ E
Sbjct: 127 LPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGD 186
Query: 345 VPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESV 404
+PK + + K + E + + E ++ + + K E ++ +E
Sbjct: 187 IPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGD 246
Query: 405 VLKGQEAQVEKSELKVPKGQEGQVEKTEADVPK--EQEVQEKKSEAGVLKGPESQVKNTE 462
+ K E ++ E +PK E ++ E D+PK E+ +Q KK + + K PE ++ E
Sbjct: 247 IPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGD--IPKSPEEAIQPKE 304
Query: 463 VSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTK 522
+P++ + ++ E + K E + + + ++ + + P E+ + +
Sbjct: 305 GDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKE 364
Query: 523 GD 524
GD
Sbjct: 365 GD 366
Score = 69.7 bits (169), Expect = 7e-12
Identities = 52/260 (20%), Positives = 110/260 (42%), Gaps = 18/260 (6%)
Query: 272 KEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVP 331
K PE + + K + ++ IPK ++ +IP+ + D+P
Sbjct: 54 KAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIP 113
Query: 332 RGQESQVKKSESGVPKG-------QEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVK 384
+ E ++ + +PK +E + KS ++ + + K+ + + +ES +
Sbjct: 114 KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP 173
Query: 385 KSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKT--------EADVP 436
KS + +E + K + ++ + + K+ +K + +EG + K+ E D+P
Sbjct: 174 KSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLP 233
Query: 437 KEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKG-QEAQEKKESFED 495
K E + E + K PE ++ E +P++LE ++ E + K +E + K+
Sbjct: 234 KSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIP 293
Query: 496 KGNND--KEKERDAEKDPNK 513
K + + KE D K P +
Sbjct: 294 KSPEEAIQPKEGDIPKSPKQ 313
Score = 67.0 bits (162), Expect = 4e-11
Identities = 36/176 (20%), Positives = 73/176 (41%)
Query: 287 KIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVP 346
K ++ + I K E ++ E +P+ I+ D+P+ E ++ E +P
Sbjct: 204 KASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIP 263
Query: 347 KGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVL 406
K E + + K E ++ + +P+ E ++ + + K + ++ +E +
Sbjct: 264 KSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIP 323
Query: 407 KGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTE 462
K E + E+ +PK E ++ E D PK E E +LK E ++ E
Sbjct: 324 KSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPE 379
Score = 52.8 bits (125), Expect = 8e-07
Identities = 38/182 (20%), Positives = 72/182 (39%), Gaps = 4/182 (2%)
Query: 272 KEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVP 331
K PE + + + K E + IPK E ++ E IP+ I+ D+P
Sbjct: 219 KSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIP 278
Query: 332 RGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVS 391
+ E ++ + +PK E + + K + ++ E +P+ E + + +
Sbjct: 279 KSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIP 338
Query: 392 KGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPK----EQEVQEKKSE 447
K E ++ +E K E E + K +E +E E D K +++ + E
Sbjct: 339 KSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKE 398
Query: 448 AG 449
AG
Sbjct: 399 AG 400
Score = 42.7 bits (99), Expect = 9e-04
Identities = 33/187 (17%), Positives = 75/187 (40%), Gaps = 17/187 (9%)
Query: 361 LKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKV 420
++ +E+ + +P+ + Q K E ++ +E + K E ++ + +
Sbjct: 8 MRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDL 67
Query: 421 PKGQEGQVEKTEADVPKE--QEVQEK-------------KSEAGVLKGPESQVKNTEVSV 465
PK E ++ E+++PK + +Q K E + K PE +++ + +
Sbjct: 68 PKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDL 127
Query: 466 PETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKD-PNKKEKGDKNTKGD 524
P++ E ++ E + K A+ + + + + E D P E+ + +GD
Sbjct: 128 PKSSEEAIQPKEGDIPK-SSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGD 186
Query: 525 KGKDKVK 531
K K
Sbjct: 187 IPKSSAK 193
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 74.3 bits (181), Expect = 3e-13
Identities = 83/315 (26%), Positives = 145/315 (46%), Gaps = 33/315 (10%)
Query: 243 QNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGIPK 302
Q EE E K+D E S+ +E E+E T+ E + G E + + + +
Sbjct: 533 QEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAE--GEEAEAKEEKKVEE 590
Query: 303 RQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLK 362
+ E ++ E + + + +K+ S VP+ + K +S VPK + KS +
Sbjct: 591 KSE-EVATKEELVADAKVEKPEKAKSPVPKSPVEE--KGKSPVPKSPVEEKGKSPVP--- 644
Query: 363 GQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPK 422
+ EK + VP+ + K +S VSK + V+++ + + KS+ +V K
Sbjct: 645 -KSPVEEKGKSPVPKSPVEE--KGKSPVSK---SPVEEKAKSPVPKSPVEEAKSKAEVGK 698
Query: 423 GQEGQVEKTEA-DVPKEQEV---QEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSES 478
G++ + E+ E + PKE++V +EK + K ES VK V+ T+ VK
Sbjct: 699 GEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVK---- 754
Query: 479 GVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKD-----KVKGK 533
V +E +E+ + + +KEKE+ + +++E DK KG + +D +V+GK
Sbjct: 755 -VHLEKETKEEGKPLQ----QEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGK 809
Query: 534 RESEINGEKSKGSKR 548
E E K KGS R
Sbjct: 810 EEVE-QETKEKGSGR 823
Score = 52.8 bits (125), Expect = 8e-07
Identities = 71/306 (23%), Positives = 136/306 (44%), Gaps = 30/306 (9%)
Query: 271 IKEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSV-SD 329
I+E + E + +++E+ + ++ K++ + K E + + A K V +
Sbjct: 457 IEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKAT 516
Query: 330 VPRGQESQVKKSESGVPKGQEAQVTKS-GLVVLKGQEAQVEKSEMGVPRRQESQVKKSQS 388
P +E + +K E +GQE + + G + +E EK G ++E + ++ ++
Sbjct: 517 APEVKEEEGEKEEE---EGQEEEEEEDEGAKSDQAEEGGSEKE--GSSEKEEGEQEEGET 571
Query: 389 GV-SKGQEAQVKKRESVVLKGQE----------AQVEKSE-LKVPKGQEGQVEKTEADVP 436
++G+EA+ K+ + V K +E A+VEK E K P + EK ++ VP
Sbjct: 572 EAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVP 631
Query: 437 KEQEVQEKKS--------EAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQE 488
K ++ KS E G P+S V+ S P + +K++S V K +
Sbjct: 632 KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKS-PVSKSPVEEKAKSPVPKSPVEEA 690
Query: 489 KKESFEDKGNNDKEKERDAEKDPN--KKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGS 546
K ++ KG +E+E++ ++ P K EK ++ K K K + + E E +
Sbjct: 691 KSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTIT 750
Query: 547 KRAKAN 552
K K +
Sbjct: 751 KSVKVH 756
Score = 52.4 bits (124), Expect = 1e-06
Identities = 63/252 (25%), Positives = 113/252 (44%), Gaps = 25/252 (9%)
Query: 334 QESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGV-SK 392
+E++V+ +S + + A +T+ V +K ++ + + + P +E +V +S V +
Sbjct: 458 EETKVEDEKSEMEEALTA-ITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKAT 516
Query: 393 GQEAQVKKRESVVLKGQEAQVEKSE-LKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVL 451
E + ++ E +GQE + E+ E K + +EG EK + +E E +E ++EA
Sbjct: 517 APEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEA- 575
Query: 452 KGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKES------FEDKGNN--DKEK 503
+G E++ K E V E E K E E EK +S E+KG + K
Sbjct: 576 EGEEAEAKE-EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSP 634
Query: 504 ERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEIN----GEKSKG--------SKRAKA 551
+ K P K ++ K K V+ K +S ++ EK+K ++KA
Sbjct: 635 VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKA 694
Query: 552 NTGRKYNKKVEE 563
G+ K+ EE
Sbjct: 695 EVGKGEQKEEEE 706
Score = 49.3 bits (116), Expect = 9e-06
Identities = 48/182 (26%), Positives = 90/182 (49%), Gaps = 25/182 (13%)
Query: 390 VSKGQEAQVKKRESVVLKGQEAQVEK--SELKVPKGQEGQVEKTEADVPKEQEV--QEKK 445
++ + Q K E+ LK Q VE+ E KV + ++ ++E+ + +E V +E+K
Sbjct: 430 ITISSKIQKPKVEAPKLKVQHKFVEEIIEETKV-EDEKSEMEEALTAITEELAVSMKEEK 488
Query: 446 SEAGVLKGPESQVKNTEVSV---PETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKE 502
EA K E + + EV+ P + K E G + +E QE++E ++ +D+
Sbjct: 489 KEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA 548
Query: 503 KERDAEKD-PNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAKANTGRKYNKKV 561
+E +EK+ ++KE+G++ +G+ E+E GE+ A+A +K +K
Sbjct: 549 EEGGSEKEGSSEKEEGEQE----------EGETEAEAEGEE------AEAKEEKKVEEKS 592
Query: 562 EE 563
EE
Sbjct: 593 EE 594
Score = 46.2 bits (108), Expect = 8e-05
Identities = 59/253 (23%), Positives = 112/253 (44%), Gaps = 24/253 (9%)
Query: 264 ESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQI 323
E KS K P E + + K + E K ++ G +++E + K + + + + +
Sbjct: 663 EKGKSPVSKSPVEEKAKSPVPKSPVE-EAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK 721
Query: 324 KKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKS--EMGVPRRQES 381
++ DVP + KK+ES V + A+V + + K + +EK E G P +QE
Sbjct: 722 EEKPKDVP-----EKKKAESPVKEEAVAEV----VTITKSVKVHLEKETKEEGKPLQQEK 772
Query: 382 QVKKS-------QSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEAD 434
+ +K+ + G KG A+ ++E + + G+ E+ E + + G+ E+ +
Sbjct: 773 EKEKAGGEGGSEEEGSDKG--AKGSRKEDIAVNGEVEGKEEVEQETKEKGSGR-EEEKGV 829
Query: 435 VPKEQEVQEKKSEAGVLKGPESQV--KNTEVSVPETLESQVKKSESGVLKGQEAQEKKES 492
V ++ + G K E V K E E + K V Q+ +E +E+
Sbjct: 830 VTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEET 889
Query: 493 FEDKGNNDKEKER 505
FE+K + K+ E+
Sbjct: 890 FEEKLVSTKKVEK 902
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 74.3 bits (181), Expect = 3e-13
Identities = 83/315 (26%), Positives = 145/315 (46%), Gaps = 33/315 (10%)
Query: 243 QNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGIPK 302
Q EE E K+D E S+ +E E+E T+ E + G E + + + +
Sbjct: 157 QEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAE--GEEAEAKEEKKVEE 214
Query: 303 RQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLK 362
+ E ++ E + + + +K+ S VP+ + K +S VPK + KS +
Sbjct: 215 KSE-EVATKEELVADAKVEKPEKAKSPVPKSPVEE--KGKSPVPKSPVEEKGKSPVP--- 268
Query: 363 GQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPK 422
+ EK + VP+ + K +S VSK + V+++ + + KS+ +V K
Sbjct: 269 -KSPVEEKGKSPVPKSPVEE--KGKSPVSK---SPVEEKAKSPVPKSPVEEAKSKAEVGK 322
Query: 423 GQEGQVEKTEA-DVPKEQEV---QEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSES 478
G++ + E+ E + PKE++V +EK + K ES VK V+ T+ VK
Sbjct: 323 GEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVK---- 378
Query: 479 GVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKD-----KVKGK 533
V +E +E+ + + +KEKE+ + +++E DK KG + +D +V+GK
Sbjct: 379 -VHLEKETKEEGKPLQ----QEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGK 433
Query: 534 RESEINGEKSKGSKR 548
E E K KGS R
Sbjct: 434 EEVE-QETKEKGSGR 447
Score = 52.8 bits (125), Expect = 8e-07
Identities = 71/306 (23%), Positives = 136/306 (44%), Gaps = 30/306 (9%)
Query: 271 IKEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSV-SD 329
I+E + E + +++E+ + ++ K++ + K E + + A K V +
Sbjct: 81 IEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKAT 140
Query: 330 VPRGQESQVKKSESGVPKGQEAQVTKS-GLVVLKGQEAQVEKSEMGVPRRQESQVKKSQS 388
P +E + +K E +GQE + + G + +E EK G ++E + ++ ++
Sbjct: 141 APEVKEEEGEKEEE---EGQEEEEEEDEGAKSDQAEEGGSEKE--GSSEKEEGEQEEGET 195
Query: 389 GV-SKGQEAQVKKRESVVLKGQE----------AQVEKSE-LKVPKGQEGQVEKTEADVP 436
++G+EA+ K+ + V K +E A+VEK E K P + EK ++ VP
Sbjct: 196 EAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVP 255
Query: 437 KEQEVQEKKS--------EAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQE 488
K ++ KS E G P+S V+ S P + +K++S V K +
Sbjct: 256 KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKS-PVSKSPVEEKAKSPVPKSPVEEA 314
Query: 489 KKESFEDKGNNDKEKERDAEKDPN--KKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGS 546
K ++ KG +E+E++ ++ P K EK ++ K K K + + E E +
Sbjct: 315 KSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTIT 374
Query: 547 KRAKAN 552
K K +
Sbjct: 375 KSVKVH 380
Score = 52.4 bits (124), Expect = 1e-06
Identities = 63/252 (25%), Positives = 113/252 (44%), Gaps = 25/252 (9%)
Query: 334 QESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGV-SK 392
+E++V+ +S + + A +T+ V +K ++ + + + P +E +V +S V +
Sbjct: 82 EETKVEDEKSEMEEALTA-ITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKAT 140
Query: 393 GQEAQVKKRESVVLKGQEAQVEKSE-LKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVL 451
E + ++ E +GQE + E+ E K + +EG EK + +E E +E ++EA
Sbjct: 141 APEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEA- 199
Query: 452 KGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKES------FEDKGNN--DKEK 503
+G E++ K E V E E K E E EK +S E+KG + K
Sbjct: 200 EGEEAEAKE-EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSP 258
Query: 504 ERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEIN----GEKSKG--------SKRAKA 551
+ K P K ++ K K V+ K +S ++ EK+K ++KA
Sbjct: 259 VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKA 318
Query: 552 NTGRKYNKKVEE 563
G+ K+ EE
Sbjct: 319 EVGKGEQKEEEE 330
Score = 49.3 bits (116), Expect = 9e-06
Identities = 48/182 (26%), Positives = 90/182 (49%), Gaps = 25/182 (13%)
Query: 390 VSKGQEAQVKKRESVVLKGQEAQVEK--SELKVPKGQEGQVEKTEADVPKEQEV--QEKK 445
++ + Q K E+ LK Q VE+ E KV + ++ ++E+ + +E V +E+K
Sbjct: 54 ITISSKIQKPKVEAPKLKVQHKFVEEIIEETKV-EDEKSEMEEALTAITEELAVSMKEEK 112
Query: 446 SEAGVLKGPESQVKNTEVSV---PETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKE 502
EA K E + + EV+ P + K E G + +E QE++E ++ +D+
Sbjct: 113 KEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA 172
Query: 503 KERDAEKD-PNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAKANTGRKYNKKV 561
+E +EK+ ++KE+G++ +G+ E+E GE+ A+A +K +K
Sbjct: 173 EEGGSEKEGSSEKEEGEQE----------EGETEAEAEGEE------AEAKEEKKVEEKS 216
Query: 562 EE 563
EE
Sbjct: 217 EE 218
Score = 46.2 bits (108), Expect = 8e-05
Identities = 59/253 (23%), Positives = 112/253 (44%), Gaps = 24/253 (9%)
Query: 264 ESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQI 323
E KS K P E + + K + E K ++ G +++E + K + + + + +
Sbjct: 287 EKGKSPVSKSPVEEKAKSPVPKSPVE-EAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK 345
Query: 324 KKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKS--EMGVPRRQES 381
++ DVP + KK+ES V + A+V + + K + +EK E G P +QE
Sbjct: 346 EEKPKDVP-----EKKKAESPVKEEAVAEV----VTITKSVKVHLEKETKEEGKPLQQEK 396
Query: 382 QVKKS-------QSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEAD 434
+ +K+ + G KG A+ ++E + + G+ E+ E + + G+ E+ +
Sbjct: 397 EKEKAGGEGGSEEEGSDKG--AKGSRKEDIAVNGEVEGKEEVEQETKEKGSGR-EEEKGV 453
Query: 435 VPKEQEVQEKKSEAGVLKGPESQV--KNTEVSVPETLESQVKKSESGVLKGQEAQEKKES 492
V ++ + G K E V K E E + K V Q+ +E +E+
Sbjct: 454 VTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEET 513
Query: 493 FEDKGNNDKEKER 505
FE+K + K+ E+
Sbjct: 514 FEEKLVSTKKVEK 526
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 73.2 bits (178), Expect = 6e-13
Identities = 82/319 (25%), Positives = 160/319 (50%), Gaps = 38/319 (11%)
Query: 275 EREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQ 334
E+EG+ + E E +V G + QE Q++ E + + +G Q+++ V R Q
Sbjct: 105 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG-QVREQEGQV-REQ 162
Query: 335 ESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQV--EKSEMGVPRRQ----ESQVKKSQS 388
E QV++ E V + QE QV + V + QE Q+ ++ +MG Q E Q++K +
Sbjct: 163 EGQVREQEGQV-REQEGQVREQEGQV-REQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEE 220
Query: 389 GVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEA 448
+ + QE Q++K+E + + QE QV+K E +V K QE Q+ K E + +EQE Q ++ E
Sbjct: 221 QMGE-QEEQMRKQEEQMGE-QEEQVQKQEEQVQK-QEEQMRKQEEQM-REQEEQMREQEE 276
Query: 449 GVLK------------GPESQVKNTEVSVPE------TLESQVKKSESGVLKGQEA--QE 488
+LK E Q++ E + E E Q+++ E + K +E ++
Sbjct: 277 QMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQ 336
Query: 489 KKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGD----KGKDKVKGKRESEINGEKSK 544
K++ +E K K++E+ E++ +++ ++ K + K +++++ + E E+
Sbjct: 337 KEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQM 396
Query: 545 GSKRAKANTGRKYNKKVEE 563
G ++ + ++ ++ EE
Sbjct: 397 GEQKEQMGEQKEQMREQEE 415
Score = 72.0 bits (175), Expect = 1e-12
Identities = 78/321 (24%), Positives = 146/321 (45%), Gaps = 51/321 (15%)
Query: 275 EREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQ 334
E+EG+ + E E +V G + QE Q++ E + + +G Q+++ V R Q
Sbjct: 126 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG-QVREQEGQV-REQ 183
Query: 335 ESQVKKSES--GVPKGQEAQVTKSGLVVLKGQEAQVEKSE--MGVPRRQESQVKKSQSGV 390
E QV++ E G +GQ + + + QE Q++K E MG QE Q++K + +
Sbjct: 184 EGQVREQEGQMGEQEGQMGEQEEQ----MGEQEEQMQKQEEQMG---EQEEQMRKQEEQM 236
Query: 391 SKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGV 450
+ QE QV+K+E V K QE Q+ K E ++ + QE Q+ + E + K++E E++ + G
Sbjct: 237 GE-QEEQVQKQEEQVQK-QEEQMRKQEEQM-REQEEQMREQEEQMLKQKEQTEQEEQTGE 293
Query: 451 -----------LKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESF------ 493
++ E Q++ E + E E K+ E + ++ E+KE
Sbjct: 294 QEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQ 353
Query: 494 ------------------EDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRE 535
E++ +E+ R E+ K+E+ K G+ K + + +
Sbjct: 354 MGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQ 413
Query: 536 SEINGEKSKGSKRAKANTGRK 556
E GE+ + ++ + + G +
Sbjct: 414 EEQMGEQKEQMRKQEEHMGEQ 434
Score = 52.4 bits (124), Expect = 1e-06
Identities = 44/189 (23%), Positives = 94/189 (49%), Gaps = 7/189 (3%)
Query: 375 VPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEAD 434
+PR ++K+ + + + + ++ + L +E + + K+P QEGQV + E
Sbjct: 1 MPRITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQ 60
Query: 435 VPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFE 494
V +EQE Q ++ E G ++ E QV+ E V E E QV++ E G ++ QE Q +++ +
Sbjct: 61 V-REQEGQVREQE-GQVREQEGQVREQEGQVREQ-EGQVREQE-GQVREQEGQVREQEGQ 116
Query: 495 DKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAKANTG 554
+ + +E++ + ++++G + + +++ RE E + +G R +
Sbjct: 117 VREQEGQVREQEGQV---REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 173
Query: 555 RKYNKKVEE 563
R+ +V E
Sbjct: 174 REQEGQVRE 182
Score = 43.5 bits (101), Expect = 5e-04
Identities = 45/201 (22%), Positives = 98/201 (48%), Gaps = 10/201 (4%)
Query: 247 EENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQET 306
E+ ++ K + E ++ + E+E + + E+ + + + + + + QE
Sbjct: 238 EQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGE-QEE 296
Query: 307 QLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEA 366
Q++ E + + Q Q+++ + R QE Q+ K E + + Q+ Q+ + + K +E
Sbjct: 297 QMREQEEQMRE-QEEQMREQEEQM-REQEEQMGKQEEQMWE-QKEQMWEQKEQMWKQEEQ 353
Query: 367 QVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEG 426
E+ E ++QE QV+K + + K QE Q++K+E + K +E + E K G++
Sbjct: 354 MGEQEEQ--MQKQEEQVRKQEEQMRK-QEEQMRKQEEQMRKQEE---QMGEQKEQMGEQK 407
Query: 427 QVEKTEADVPKEQEVQEKKSE 447
+ + + + EQ+ Q +K E
Sbjct: 408 EQMREQEEQMGEQKEQMRKQE 428
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 66.6 bits (161), Expect = 6e-11
Identities = 79/364 (21%), Positives = 151/364 (41%), Gaps = 31/364 (8%)
Query: 220 DEELAKKSCSKIQILKCGGTARSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGK 279
D+ + C + K T NS N + N + N E K KE + +
Sbjct: 1228 DKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKE-KEKKEKTP 1286
Query: 280 GTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMS---------IPQGQGAQIKKSVSDV 330
T E +G + K P + E + E + + + A+ +K + V
Sbjct: 1287 ATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTV 1346
Query: 331 PRGQESQVKKSESGVPKGQEAQVTKS--GLVVLKGQE---------AQVEKSEMGVPRRQ 379
P + ++ E +E + K +KG E + V +S++ P R+
Sbjct: 1347 PNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPERE 1406
Query: 380 ESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVP--KGQEGQVEKTEADVPK 437
+ + +K + S + VK + LK A++ + P K +E +++K + D +
Sbjct: 1407 QKR-RKIDTHPSPSHSSTVKD-SLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSR 1464
Query: 438 EQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKG 497
E+ + +K + K + N + VP L + +K E+G + G + + E
Sbjct: 1465 ERSREREKKDEKDRKERKRDHSNNDREVPPDLTKR-RKEENGTM-GVSKHKSESPCESPY 1522
Query: 498 NNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVK--GKRESEINGEKSKGSKRAKANTGR 555
N+K+KE++ K + KEKG + K +K DK+ GK+ES + EK + ++ ++ G+
Sbjct: 1523 PNEKDKEKNKSKS-SGKEKGSDSFKSEK-MDKISSGGKKESRHDKEKIEKKEKRDSSGGK 1580
Query: 556 KYNK 559
+ K
Sbjct: 1581 EEKK 1584
Score = 49.7 bits (117), Expect = 7e-06
Identities = 65/298 (21%), Positives = 121/298 (40%), Gaps = 41/298 (13%)
Query: 239 TARSQNSREE-NKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSD 297
T +S +E+ KE D F +V + +S +E ERE K E+D I E+K S
Sbjct: 1321 TPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQERERE-KEPSRERD-IAKEMK--SK 1376
Query: 298 AGIPKRQETQLKISEMS-IPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKS 356
+ ++T + S S +P+ SD+P + Q ++ P + K
Sbjct: 1377 ENVKGGEKTPVSGSLKSPVPR----------SDIPEPEREQKRRKIDTHPSPSHSSTVKD 1426
Query: 357 GLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKS 416
L+ LK A++ + P +SK +E ++ K++ + + + EK
Sbjct: 1427 SLIELKESSAKLYINHTPPP-------------LSKSKEREMDKKDLDKSRERSREREKK 1473
Query: 417 ELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKS 476
+ K K ++ + +VP + + K+ + E P + + KS
Sbjct: 1474 DEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKS 1533
Query: 477 ES-GVLKGQEAQE-----------KKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTK 522
+S G KG ++ + KKES DK +K+++RD+ +K+ + K
Sbjct: 1534 KSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDK 1591
Score = 43.9 bits (102), Expect = 4e-04
Identities = 46/184 (25%), Positives = 78/184 (42%), Gaps = 29/184 (15%)
Query: 409 QEAQVEKSEL-KVPKGQEGQVEKTEADVPKEQEVQEK-----KSEAGVLKGPE------- 455
QE + ++ +L + G GQ++ ++ + E E K + A V GP
Sbjct: 1153 QEEKEKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSS 1212
Query: 456 --SQVKNTEVSVPETLESQ---------VKKSESGVLKGQEAQEKKESFEDKGNNDKEKE 504
S K+ E S ET +S+ V K+ S KG + S +K + +KE
Sbjct: 1213 IGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKE 1272
Query: 505 RDAEKDPNKKEKGDKNTK-----GDKGKDKVKGKRESEINGEKSKGSKRAKANTGRKYNK 559
+ EK+ KKEK T G GK+K K +R ++ + + K++ ++ K
Sbjct: 1273 KGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFK 1332
Query: 560 KVEE 563
K E+
Sbjct: 1333 KEEK 1336
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 66.6 bits (161), Expect = 6e-11
Identities = 69/311 (22%), Positives = 143/311 (45%), Gaps = 23/311 (7%)
Query: 262 SVESLKSAHIKEPEREGKGTDLEKDKI-GMEVKVDSDAGIPKRQETQLKISEMSIPQGQG 320
S E ++ KE + KG +E+ ++ E V G ++++T++ +++
Sbjct: 580 SDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGG--RKEKTEILSDDLTDKAEVS 637
Query: 321 AQIKKSVSDVPRGQESQ----VKKSESGVPKGQEAQVTKS----GLVVLK----GQEAQV 368
KSV + G E + ++ SG Q+ + K G ++ G++
Sbjct: 638 EGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELA 697
Query: 369 EKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKR-ESVVLKGQEAQVEKSELKVPKGQ--- 424
EK E +E + K+ + G K + ++++ E +G+E + ++ E + +G+
Sbjct: 698 EKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKE 757
Query: 425 EGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQ 484
EG+ E+ E + KE+ ++K+ AG + E + E ET +K E G ++G
Sbjct: 758 EGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGG 817
Query: 485 EAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKR-ESEINGEKS 543
E +E K E++ ++E E + E+ ++E+G+ + +GK + +G+ E E GE+
Sbjct: 818 EVEEGKGEREEE---EEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEG 874
Query: 544 KGSKRAKANTG 554
+G + G
Sbjct: 875 EGEGEEEEGEG 885
Score = 65.1 bits (157), Expect = 2e-10
Identities = 69/305 (22%), Positives = 134/305 (43%), Gaps = 28/305 (9%)
Query: 246 REENKEALKNDIIFTNSVESLKSAHIKE----PEREGKGTDLEKDKIGMEVKVDSDAGIP 301
R+E E L +D+ V K+ + E PE G GT E+ G E D +
Sbjct: 619 RKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGT-CEEGSSGAEHWQDEER--- 674
Query: 302 KRQETQLKISEMSIP-QGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVV 360
++ E EM P +G+ +K G+E + K+ E G K + ++ + G
Sbjct: 675 EKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGG--- 731
Query: 361 LKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKV 420
+E E E R +E + + +G+E + ++ + + +E + K E
Sbjct: 732 ---EEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGE 788
Query: 421 PKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGV 480
+G +G+ E+ E + E+ K E G ++G E + E E + ++ E
Sbjct: 789 EEGDQGEGEEEETEGRGEE-----KEEGGEVEGGEVEEGKGE------REEEEEEGEGEE 837
Query: 481 LKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEING 540
+G+ +E+ E E++G E+E + + + E+G+ +G++ + + +G+ E E G
Sbjct: 838 EEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGE--GEGEEEEGEGEGEEEGEGEG 895
Query: 541 EKSKG 545
E+ +G
Sbjct: 896 EEEEG 900
Score = 58.9 bits (141), Expect = 1e-08
Identities = 67/295 (22%), Positives = 138/295 (46%), Gaps = 19/295 (6%)
Query: 272 KEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVP 331
+E E EG+G EK++ G + + G +R+E + + E +G+G + ++ +
Sbjct: 797 EEEETEGRGE--EKEEGGEVEGGEVEEGKGEREEEEEE-GEGEEEEGEGEE-EEGEGEEE 852
Query: 332 RGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVS 391
G+ ++ E G +G+E G + E + E+ G +E + + + G
Sbjct: 853 EGEGKGEEEGEEG--EGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEG 910
Query: 392 KGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVL 451
+G+E + + + +G+E + E E + EG+ E E + +E+ E + E G
Sbjct: 911 EGEEEEGEGKGEE--EGEEGEGEGEE----EEGEGEGEDGEGEGEEEEGEWEGEEEEGEG 964
Query: 452 KGPESQVKNTEVSVPETLESQVK---KSESGVLKGQEAQEKKESFEDKGNNDKEKERDAE 508
+G E E E E + + + E G +G+E E +E E +G ++E E + E
Sbjct: 965 EGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGE 1024
Query: 509 KDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAKANTGRKYNKKVEE 563
+ E+G+ + ++G+++ + +RE E GE+++ ++ + KY + EE
Sbjct: 1025 VEG---EEGEGEGEEEEGEEEGE-EREKEGEGEENRRNREEEEEEEGKYQETGEE 1075
Score = 58.5 bits (140), Expect = 2e-08
Identities = 63/292 (21%), Positives = 135/292 (46%), Gaps = 23/292 (7%)
Query: 272 KEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVP 331
+E E EG+G + E + E + + + G K +E +G+G + +
Sbjct: 827 EEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEG--------EEGEGEEEGEEGEGEG 878
Query: 332 RGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVK-KSQSGV 390
+E + + E G +G+E + G +G+ + E G +E + + + + G
Sbjct: 879 EEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGE 938
Query: 391 SKGQEAQVKKRESVVLKGQ-EAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAG 449
+G++ + + E +G+ E + E+ E + + EG+ E+ E + +E+ E + E G
Sbjct: 939 GEGEDGEGEGEEE---EGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEG 995
Query: 450 VLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQ-EAQEKKESFEDKGNNDKEKERDAE 508
+G E E E E + ++ E G ++G+ E +E + E++ ++ +ER+ E
Sbjct: 996 EEEGEE------EGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKE 1049
Query: 509 KDPNKKEKGDKNTKGDKGKDKVKGKRESE-INGEKSKGSKRAKANTGRKYNK 559
+ + + + + ++GK + G+ E+E +GE+ K + K + KY K
Sbjct: 1050 GEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSV--KYGK 1099
Score = 57.4 bits (137), Expect = 3e-08
Identities = 74/380 (19%), Positives = 160/380 (42%), Gaps = 41/380 (10%)
Query: 217 GYMDEELAKKSCSKIQILKCGGTARSQNSREENKEALKNDIIFTNSVESLKSAHIKEPER 276
G ++ELA+K K K G + Q RE+ + +N + E +E +R
Sbjct: 690 GEGEKELAEKEEWK----KRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDR 745
Query: 277 E------------GKGTDLE------------KDKIGMEVK--VDSDAGIPKRQETQLKI 310
E G+G ++E +++ G E K + D G + +ET+ +
Sbjct: 746 EEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRG 805
Query: 311 SEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEK 370
E +G +++ + +G+ + ++ G + E + + +G+ E+
Sbjct: 806 EEKE----EGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEE 861
Query: 371 SEMGVPRRQESQVK---KSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQ-EG 426
E G + + + + + G +G+E + E +G+ + + E + +G+ +G
Sbjct: 862 GEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKG 921
Query: 427 QVEKTEADVPKEQEVQEKKSEAGVLKGPESQVK---NTEVSVPETLESQVKKSESGVLKG 483
+ E E + E+E E + E G +G E + + E E E + E G +G
Sbjct: 922 EEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEG 981
Query: 484 QEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKS 543
+E + + E E++G + E+E + E++ + + ++ + + + +G+ E E +
Sbjct: 982 EEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEE 1041
Query: 544 KGSKRAKANTGRKYNKKVEE 563
+G +R K G + + EE
Sbjct: 1042 EGEEREKEGEGEENRRNREE 1061
Score = 42.0 bits (97), Expect = 0.002
Identities = 34/160 (21%), Positives = 72/160 (45%), Gaps = 14/160 (8%)
Query: 406 LKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEA--GVLKGPESQVKNTEV 463
++ QE + + +KV G++ + E D+ + EV E K+++ GPE + T
Sbjct: 601 IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGT-- 658
Query: 464 SVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKG 523
++ SG Q+ +E+++ +DKG + E+ + EK+ +KE+ K
Sbjct: 659 ---------CEEGSSGAEHWQD-EEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGE 708
Query: 524 DKGKDKVKGKRESEINGEKSKGSKRAKANTGRKYNKKVEE 563
++ + + + + E N E +G + + + EE
Sbjct: 709 EQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEE 748
Score = 37.0 bits (84), Expect = 0.048
Identities = 55/289 (19%), Positives = 118/289 (40%), Gaps = 38/289 (13%)
Query: 272 KEPEREGKGTDLEKDKIGMEV------KVDSDAGIPKRQETQLKISEMSIPQGQGAQIKK 325
+E E EGKG + ++ G E + + + G + +E E +G+G + +
Sbjct: 850 EEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGE 909
Query: 326 SVSDVPRGQESQVKKSESGVPKGQEAQ------------VTKSGLVVLKGQEAQVEKSEM 373
+ G+ ++ E G +G+E + + G + +E + E E
Sbjct: 910 GEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEE 969
Query: 374 GVPRRQESQVK-KSQSGVSKGQEAQVKKRESVVLKGQEA------QVEKSELKVP-KGQE 425
G +E + + + + G +G+E + ++ +G+E + E+ E++ +G+E
Sbjct: 970 GEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEE 1029
Query: 426 GQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQ-----------VK 474
G+ E E + +E E +EK+ E + + + E ET E + V
Sbjct: 1030 GEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVS 1089
Query: 475 KSESGVLKGQ-EAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTK 522
K + V G+ + +KK +GN +++ + + + G +K
Sbjct: 1090 KIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSK 1138
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 64.3 bits (155), Expect = 3e-10
Identities = 77/316 (24%), Positives = 136/316 (43%), Gaps = 25/316 (7%)
Query: 245 SREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQ 304
S E+ K +K + +S K PE K EK K ++VK +A P ++
Sbjct: 718 SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPE---KAKSPEKAKT-LDVK-SPEAKTPAKE 772
Query: 305 ETQLKISEMSIPQGQGAQIKKSVSDVPRGQ---ESQVKKSESGVPKGQEAQVTKSGLVVL 361
E + + P+ + +K+ V + + + K E +PK +E + +
Sbjct: 773 EARSPADKF--PEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP------V 824
Query: 362 KGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVE-KSELKV 420
K +E E P++ E + K+ + ++ KK E+ + + +VE K E V
Sbjct: 825 KEEEKPQEVKVKEPPKKAEEE--KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAV 882
Query: 421 PKGQEGQVE--KTEADVPKEQEVQEKKSEAGV-LKGPESQVKNTEVSVPETLESQVKKSE 477
K +E +VE K EA+ K+ EK++ A V +K + TEV+ E +++ K+
Sbjct: 883 EKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPS 942
Query: 478 SGVLKGQEAQEKKESFEDKGNNDKEK---ERDAEKDPNKKEKGDKNTKGDKGKDKVKGKR 534
K + A EKK++ E+K +EK E A++D K K +K + +
Sbjct: 943 KPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQ 1002
Query: 535 ESEINGEKSKGSKRAK 550
+ EK+ K AK
Sbjct: 1003 KDSKPPEKATEDKAAK 1018
Score = 59.7 bits (143), Expect = 7e-09
Identities = 81/345 (23%), Positives = 137/345 (39%), Gaps = 43/345 (12%)
Query: 245 SREENKEALKNDIIFTNSVESLKSAHIKEPER-------EGKGTDLEKDKIGMEVKVDSD 297
S E+ K +K + +S A K PE+ E K + K + E K
Sbjct: 662 SPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEK 721
Query: 298 AGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSG 357
A P ++E + S P + A+ + + + VK E+ P +EA +S
Sbjct: 722 AKSPVKEEAKTPEKAKS-PVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEA---RSP 777
Query: 358 LVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSE 417
+ K E+ P + +S +K+ +K E ++ K+E V +E + + E
Sbjct: 778 ADKFPEKAKSPVKEEVKSPEKAKSPLKED----AKAPEKEIPKKEEVKSPVKEEE-KPQE 832
Query: 418 LKVPKG-QEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQV---KNTEVSVPETLESQV 473
+KV + ++ + EK A E++ KK EA + P+ +V K V P+ + +
Sbjct: 833 VKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEA 892
Query: 474 KKSESGVLKGQEAQEK--------KESFEDKGNND-----------KEKERDAEKD---P 511
KK E+ K EK KE + K + KE + AEK P
Sbjct: 893 KKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAP 952
Query: 512 NKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAKANTGRK 556
KK+ ++ K + K K + K + E + SK + KA K
Sbjct: 953 EKKDTKEEKAKKPEEKPKTEAKAK-EDDKTLSKEPSKPKAEKAEK 996
Score = 55.5 bits (132), Expect = 1e-07
Identities = 67/286 (23%), Positives = 127/286 (44%), Gaps = 33/286 (11%)
Query: 266 LKSAHIKEPERE------GKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQ 319
+KS K P +E K + K + EVK A P +++ K E IP+ +
Sbjct: 761 VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDA--KAPEKEIPKKE 818
Query: 320 GAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQ 379
++K V + + QE +VK+ + ++A T ++ + K E P+ +
Sbjct: 819 --EVKSPVKEEEKPQEVKVKEPPKKAEE-EKAPATPKTEEKKDSKKEEAPKKEAPKPKVE 875
Query: 380 ESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQ 439
E K + V K +E++V+ ++ +EA+ +K K +VE E PKE+
Sbjct: 876 E----KKEPAVEKPKESKVEAKK------EEAEDKKKVPTPEKEAPAKVEVKEDAKPKEK 925
Query: 440 -EVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGN 498
EV +K+ + K P + E + PE +++ +K++ + +EK ++
Sbjct: 926 TEVAKKEPDDAKAKEPSKPAEKKEAA-PEKKDTKEEKAK-------KPEEKPKTEAKAKE 977
Query: 499 NDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSK 544
+DK ++ K K EK +K++ D+ KD ++ +E K K
Sbjct: 978 DDKTLSKEPSKP--KAEKAEKSSSTDQ-KDSKPPEKATEDKAAKGK 1020
Score = 45.4 bits (106), Expect = 1e-04
Identities = 67/304 (22%), Positives = 127/304 (41%), Gaps = 42/304 (13%)
Query: 282 DLEKDKIGMEVKVDSDAGIPKRQETQLKISEM--SIPQGQGAQIKKSVSDVPRGQESQVK 339
DL K+ +++++ + + + +E ++ + S+P+G + +P
Sbjct: 387 DLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEG--------LPKIPSVSTHIKV 438
Query: 340 KSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKG---QEA 396
KSE + K E ++ +V + +E QV + V +E + K+ + +G +EA
Sbjct: 439 KSEEKI-KVVEKSEKETVIVEEQTEETQVTEE---VTEEEEKEAKEEEGKEEEGGEEEEA 494
Query: 397 QVKKRESVVLKGQEAQVEKSELKVPKGQEGQV-------EKTEADVPKEQEVQEK----- 444
+ + E+ +EA + E K P +E + EK EA P E + EK
Sbjct: 495 EGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPA 554
Query: 445 KSEAGV---LKGPESQVKNT--EVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNN 499
K EA K PE + + EV PE +S K+ + + ++ K +++ +
Sbjct: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS 614
Query: 500 DKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEING-EKSKGSKRAKANTGRKYN 558
E K P K+E K+ K +K K + E EK+K ++ +A + K
Sbjct: 615 PAEA-----KSPVKEEA--KSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAK 667
Query: 559 KKVE 562
V+
Sbjct: 668 SPVK 671
Score = 29.6 bits (65), Expect = 7.7
Identities = 38/193 (19%), Positives = 80/193 (41%), Gaps = 6/193 (3%)
Query: 364 QEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEK--SELKVP 421
QE E R E + KS + Q ++++ R + + +++ +EL+
Sbjct: 315 QEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNT 374
Query: 422 KGQEGQVEKTEADVPKEQEVQEKKSEA--GVLKGPESQVKNTEV--SVPETLESQVKKSE 477
K + + D+ + + + A +L+G E ++ + S+PE L S
Sbjct: 375 KWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVST 434
Query: 478 SGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESE 537
+K +E + E E + +E+ + + E+ +K K ++GK++ G+ E
Sbjct: 435 HIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEA 494
Query: 538 INGEKSKGSKRAK 550
GE+ S A+
Sbjct: 495 EGGEEETKSPPAE 507
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 63.2 bits (152), Expect = 6e-10
Identities = 64/268 (23%), Positives = 124/268 (46%), Gaps = 27/268 (10%)
Query: 301 PKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVV 360
PKR+ +L S M +P + K++ S +S + + E+ Q TK VV
Sbjct: 16 PKRRSARL--SAMLVPVTPEVKPKRTSSSRKMKTKSDMME-ENIDTSAQAVAETKQEAVV 72
Query: 361 LKGQEAQVEKSEMGV---PRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSE 417
+ + E + P ++ V+ + + E +K+E+V + + + ++ E
Sbjct: 73 EEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKE 132
Query: 418 LKVPKGQE-GQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKS 476
+ + +E G+ K + D E++ +E K+ G KG +++ K KK
Sbjct: 133 DEEDQNEEKGEAGKEDKDEKGEEDGKEDKN--GNEKGEDAKEKEDG-----------KKG 179
Query: 477 ESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKD-KVKGKRE 535
E G G++ +EK E ++K D+++ D +++ + KEKGDK +GKD KVK +
Sbjct: 180 EDGKGNGEDGKEKGE--DEKEEEDRKETGDGKENEDGKEKGDKK----EGKDVKVKEDEK 233
Query: 536 SEINGEKSKGSKRAKANTGRKYNKKVEE 563
+G++ +G +A ++ K+ EE
Sbjct: 234 EREDGKEDEGGNEEEAGKEKEDLKEEEE 261
Score = 52.0 bits (123), Expect = 1e-06
Identities = 65/276 (23%), Positives = 130/276 (47%), Gaps = 36/276 (13%)
Query: 241 RSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGI 300
R+ +SR K K+D++ N S ++ + E + E K G E K+ ++A
Sbjct: 38 RTSSSR---KMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNG-EAKI-TEAPA 92
Query: 301 PKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVV 360
+++ ++K + +G + K++V+ ++VK E + +E Q +
Sbjct: 93 SEKEIVEVKEENIEDATEKGGEKKEAVA-------AEVKNEEEDQKEDEEDQNEE----- 140
Query: 361 LKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKV 420
KG+ + +K E G E K+ ++G KG++A+ K+ KG++ + + K
Sbjct: 141 -KGEAGKEDKDEKG-----EEDGKEDKNGNEKGEDAKEKEDGK---KGEDGKGNGEDGK- 190
Query: 421 PKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGV 480
++G+ EK E D +++ K++E G KG + + K+ +V E K+ E G
Sbjct: 191 ---EKGEDEKEEED--RKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGG- 244
Query: 481 LKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEK 516
+EA ++KE +++ +E E ++D KKE+
Sbjct: 245 -NEEEAGKEKEDLKEEEEGKEEDE--IKEDDGKKEE 277
>gi|4557509 cylicin 2 [Homo sapiens]
Length = 348
Score = 60.5 bits (145), Expect = 4e-09
Identities = 69/261 (26%), Positives = 112/261 (42%), Gaps = 36/261 (13%)
Query: 292 VKVDSDAG-IPKRQE---TQLKISEMSIPQGQGAQIKKSVSDVPRGQESQV--------- 338
V+VDS A I K+ E TQ ++ QG + K D+ +G+E ++
Sbjct: 105 VEVDSKAAEIGKKGEDKTTQKDTTDSESELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKG 164
Query: 339 -KKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQ 397
K +E G E++ K G K + + S G ES+ +K G E
Sbjct: 165 KKDAEKGKDSATESEDEKGG--AKKDNKKDKKDSNKGKDSATESEGEKG------GTEKD 216
Query: 398 VKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQ 457
KK + KG+++ +E L+ K E + E + D K E ++ K +A +K +
Sbjct: 217 SKKGKKDSKKGKDSAIE---LQAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKGKKD 273
Query: 458 VKNTEVSVPETLESQVKKSESGVLKGQEAQEKK----ESFEDKGNNDKEKERDAEKDPNK 513
K + ++ + K+S+ K + KK ES + K + K ++DA+KD
Sbjct: 274 KKKPSSTDSDSKDDVKKESKKDATKDAKKVAKKDTEKESADSKKDAKKNAKKDAKKDAK- 332
Query: 514 KEKGDKNTKGDKGKD-KVKGK 533
KN K D+ KD K KGK
Sbjct: 333 -----KNAKKDEKKDAKKKGK 348
Score = 56.6 bits (135), Expect = 6e-08
Identities = 48/224 (21%), Positives = 99/224 (44%), Gaps = 17/224 (7%)
Query: 354 TKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSG--VSKGQEAQV------KKRESVV 405
+K+ + KG++ +K + K S+ G + KG+E ++ KK +
Sbjct: 109 SKAAEIGKKGEDKTTQKDTTDSESELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGKKDA 168
Query: 406 LKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSV 465
KG+++ E + K ++ + +K +++ K+ + + + G K + K+++
Sbjct: 169 EKGKDSATESEDEKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGK 228
Query: 466 PETLESQV-----KKSESG---VLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKG 517
+E Q KK E G KG E+++ K+ ++ K+K++ + D + K+
Sbjct: 229 DSAIELQAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDV 288
Query: 518 DKNTKGDKGKDKVK-GKRESEINGEKSKGSKRAKANTGRKYNKK 560
K +K D KD K K+++E SK + A K + K
Sbjct: 289 KKESKKDATKDAKKVAKKDTEKESADSKKDAKKNAKKDAKKDAK 332
Score = 32.3 bits (72), Expect = 1.2
Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 4/67 (5%)
Query: 485 EAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRES-EINGEKS 543
E K KG DK ++D ++ ++G K++K KGKD KGK E + +
Sbjct: 106 EVDSKAAEIGKKGE-DKTTQKDTTDSESELKQGKKDSK--KGKDIEKGKEEKLDAKKDSK 162
Query: 544 KGSKRAK 550
KG K A+
Sbjct: 163 KGKKDAE 169
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 60.5 bits (145), Expect = 4e-09
Identities = 51/218 (23%), Positives = 103/218 (47%), Gaps = 7/218 (3%)
Query: 333 GQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSK 392
G +S++++ E + +E + + + +E + K E R++E + KK + G K
Sbjct: 33 GWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRE-RGKKEKKGERK 91
Query: 393 GQEAQVKKR--ESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGV 450
+E + KKR E +G+E + K + K +G+ + E E + +E++ +E+K
Sbjct: 92 KEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSK-EGKERERKEERKREERKERERK 150
Query: 451 LKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKD 510
+ E + + E E + K+ E K +E +E+K+ ++ KE+ER ++
Sbjct: 151 KEEREKERERKERKKRERKQVGEKEEER---KEKERKERKKRERNRKERKKERERKERRE 207
Query: 511 PNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKR 548
K+ K + K ++ KD+ RE E + K K+
Sbjct: 208 RKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 57.4 bits (137), Expect = 3e-08
Identities = 43/187 (22%), Positives = 86/187 (45%), Gaps = 8/187 (4%)
Query: 377 RRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVP 436
R +E +++ + G + + + K+R + +E + E+ + K ++G+ +K E +
Sbjct: 39 REREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERK 98
Query: 437 KEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDK 496
K + +E K K + + K + E E + K+ ++ +E+KE K
Sbjct: 99 KRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEE-------RKREERKERERKK 151
Query: 497 GNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAKANTGRK 556
+KE+ER K +K+ G+K + + + K + KRE E+ K +R + +K
Sbjct: 152 EEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERN-RKERKKERERKERRERKK 210
Query: 557 YNKKVEE 563
KK EE
Sbjct: 211 ERKKKEE 217
Score = 56.2 bits (134), Expect = 8e-08
Identities = 49/203 (24%), Positives = 100/203 (49%), Gaps = 6/203 (2%)
Query: 361 LKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKV 420
++ +E ++E + G R ES+ KK + K + + K+R+ K ++ K E +
Sbjct: 38 IREREREIETRKEGKKER-ESERKKERREREKRKREREKERKRERGKKEKKGERKKEERE 96
Query: 421 PKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGV 480
K + + E E + ++++ +EKK K + + + E E E + KK E
Sbjct: 97 RKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEERE- 155
Query: 481 LKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEING 540
K +E +E+K+ E K +KE+ER EK+ +++K ++N K ++ K++ + +R
Sbjct: 156 -KERERKERKKR-ERKQVGEKEEER-KEKERKERKKRERNRK-ERKKERERKERRERKKE 211
Query: 541 EKSKGSKRAKANTGRKYNKKVEE 563
K K ++ + R+ N + +E
Sbjct: 212 RKKKEERKKERQKDRQTNWREKE 234
Score = 53.1 bits (126), Expect = 7e-07
Identities = 40/198 (20%), Positives = 95/198 (47%), Gaps = 6/198 (3%)
Query: 363 GQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPK 422
G ++++ + E + R+E + ++ + +E + +KRE + +E + E+ + K K
Sbjct: 33 GWQSEIREREREIETRKEGKKERESERKKERREREKRKRE----REKERKRERGK-KEKK 87
Query: 423 GQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLK 482
G+ + E+ +E+E +E + + K + + T E + +K E +
Sbjct: 88 GERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKER 147
Query: 483 GQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEK 542
++ +E+++ E K +E+++ EK+ +KEK K K + +++ + K+E E +
Sbjct: 148 ERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERK-KRERNRKERKKERERKERR 206
Query: 543 SKGSKRAKANTGRKYNKK 560
+ +R K +K +K
Sbjct: 207 ERKKERKKKEERKKERQK 224
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 59.3 bits (142), Expect = 9e-09
Identities = 79/373 (21%), Positives = 165/373 (44%), Gaps = 41/373 (10%)
Query: 220 DEELAK----KSCSKIQILKCGGTARSQNSREENKEALKNDI-----IFTNSVESLKSAH 270
DEE AK K +++ K + + ++ R+ +E +K+ + + S E ++
Sbjct: 244 DEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPT 303
Query: 271 IKEPEREG----------KGTDLEKDK--------IGMEVKVDSDAGIPKRQETQLKISE 312
E + EG KG EK+K ++ ++ A + + +E Q + E
Sbjct: 304 AAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEE 363
Query: 313 MSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSE 372
I + + + K+ + ++ + KK + K ++ ++ K G ++ K Q ++E
Sbjct: 364 ERIKRLEELEAKRKEEERLEQEKRERKKQKE---KERKERLKKEGKLLTKSQREARARAE 420
Query: 373 --MGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKS-EL--KVPKGQEGQ 427
+ + + Q +V S K + KKR+ + + + +V +S EL V ++G
Sbjct: 421 ATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGV 480
Query: 428 VEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQ 487
EK E P E E +E +AG L E+ + E E + ++ E+ +E +
Sbjct: 481 PEKEETPPPVEPEEEEDTEDAG-LDDWEAMASDEETEKVEGNKVHIEVKEN---PEEEEE 536
Query: 488 EKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRES-EINGEKSKGS 546
E++E ED+ +++E+E + E + ++ ++ D+ +K K K+ S E++ + S
Sbjct: 537 EEEEEEEDE-ESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDS 595
Query: 547 KRAKANTGRKYNK 559
+ R Y+K
Sbjct: 596 DDDRTKEERAYDK 608
Score = 55.1 bits (131), Expect = 2e-07
Identities = 51/206 (24%), Positives = 97/206 (47%), Gaps = 19/206 (9%)
Query: 339 KKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQV 398
KK+E + ++ K+ L LK EK E+ ++ +S+ K+SQ K +E V
Sbjct: 231 KKAEKKERERKKRDEEKAKLRKLK------EKEELETGKKDQSKQKESQR---KFEEETV 281
Query: 399 KKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPK---EQEVQEKKSEAGVLKGPE 455
K + +V A EK+E + + +K + D K E+E +EK+ + G K
Sbjct: 282 KSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATV 341
Query: 456 SQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKE 515
++ + E E Q ++ E + + +E + K++ E++ +++ER +K+ +KE
Sbjct: 342 KAMQEALAKLKEEEERQKREEEERIKRLEELEAKRK--EEERLEQEKRERKKQKEKERKE 399
Query: 516 KGDKNTKGDKGKDKVKGKRESEINGE 541
+ K +GK K +RE+ E
Sbjct: 400 RLKK-----EGKLLTKSQREARARAE 420
Score = 47.8 bits (112), Expect = 3e-05
Identities = 77/354 (21%), Positives = 142/354 (40%), Gaps = 43/354 (12%)
Query: 240 ARSQNSREENKEALKNDIIFTNSVE-SLKSAHIKEPER----------EGKGTDLEKDKI 288
++ + +E+ K+ D I E SL++ IK E + T +K K
Sbjct: 40 SKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKK 99
Query: 289 GMEVKVDS-----DAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSES 343
G + K S + + K ++ + G+ + +P+ + + +KS
Sbjct: 100 GQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNK 159
Query: 344 GVPKGQE----AQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSG--VSKGQEAQ 397
+E ++ K + E+ E E R+ + + +K++ G + G E
Sbjct: 160 KWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNED- 218
Query: 398 VKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQE--KKSEAGVLKGPE 455
+ K + +K+E K + ++ EK + KE+E E KK ++ K E
Sbjct: 219 ----DDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQS---KQKE 271
Query: 456 SQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKE 515
SQ K E ET++S+V + +E E + ED DK K++D +K +KE
Sbjct: 272 SQRKFEE----ETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDK-KKKDKKKKKGEKE 326
Query: 516 KGDKNTKGDKGKDKVKGKRES------EINGEKSKGSKRAKANTGRKYNKKVEE 563
+ +K K K VK +E+ E +K + +R K + +K EE
Sbjct: 327 EKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEE 380
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 59.3 bits (142), Expect = 9e-09
Identities = 75/291 (25%), Positives = 125/291 (42%), Gaps = 32/291 (10%)
Query: 275 EREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQ 334
E+EG+ EK K+ E K I K+ E + I G+ ++ K+ +
Sbjct: 311 EKEGEKKKAEK-KVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKI--AA 367
Query: 335 ESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQ 394
++ KK E K ++++ TK + A+VE+ + ++QE + K + S +
Sbjct: 368 QAAAKKDE----KKEDSKKTK--------KPAEVEQPK---GKKQEKKEKHVEPAKSPKK 412
Query: 395 EAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVE-KTEADVPKEQEVQEKKS--EAGVL 451
E V + V K + A+ E + + K G+ E KT V EQE++++KS + +L
Sbjct: 413 EHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTV--EQEIRKEKSGKTSSIL 470
Query: 452 KGPESQVKNTEVSVPETL---ESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAE 508
K E +K E VP +L E + KK E G+E + K + K E + E
Sbjct: 471 KDKEP-IKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKE 529
Query: 509 KDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAKANTGRKYNK 559
P EK + +D VK ++ + K K+ KA T K K
Sbjct: 530 AKPAISEKVQIHK-----QDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAK 575
Score = 50.1 bits (118), Expect = 6e-06
Identities = 87/393 (22%), Positives = 163/393 (41%), Gaps = 32/393 (8%)
Query: 174 PPSAPRGPPMAPIIISQR-TARIPQVHTMDSSGKITLTPVVILTGYMDEELAKKSCSK-- 230
P +P PP P + R T P + + K V T ++E KK K
Sbjct: 284 PGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKET 343
Query: 231 -IQILKCGGTARSQNSREENK----EALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEK 285
I + K S+ + K A K D +S ++ K A +++P+ GK + ++
Sbjct: 344 AIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPK--GKKQEKKE 401
Query: 286 DKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGV 345
+ + +P ++ + K +E + + IKK+V P +E + K+
Sbjct: 402 KHVEPAKSPKKEHSVPSDKQVKAK-TERAKEEIGAVSIKKAV---PGKKEEKTTKTVE-- 455
Query: 346 PKGQEAQVTKSGLV--VLKGQEAQVEKSEMGVP---RRQESQVKKSQSGVSKGQEAQVKK 400
QE + KSG +LK +E ++ E VP + +E + KK + G+E + K
Sbjct: 456 ---QEIRKEKSGKTSSILKDKEP-IKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKP 511
Query: 401 RESVVLKGQEAQVE-KSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVK 459
+ K ++ + + K E K ++ Q+ K + P E+ V K E VLK ++
Sbjct: 512 PQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKP-EKTVSHGKPEEKVLKQVKAVTI 570
Query: 460 NTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDK 519
T +++ ++ E +K + + + + + K+K +EK+ KEK D
Sbjct: 571 EKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKE--SKEKADM 628
Query: 520 NTKGDKGKDKVKGKRESEINGEKSKGSKRAKAN 552
++KV ++ES +K K A+ +
Sbjct: 629 K---HLREEKVSTRKESLQLHNVTKAEKPARVS 658
Score = 47.0 bits (110), Expect = 5e-05
Identities = 92/401 (22%), Positives = 161/401 (40%), Gaps = 58/401 (14%)
Query: 182 PMAPIIISQRTARIPQVHTMDSSGKITLTPVVILTG-----YMDEELAKKSCSKIQILKC 236
P +P + +RT V T S L +I+T M + + K+ S I K
Sbjct: 25 PKSPGKVLKRTVTEDIVTTFSSPAAWLLVIALIITWSAVAIVMFDLVDYKNFSASSIAKI 84
Query: 237 GGTARS--QNSREENKE------ALKNDIIFTNSVES------LKSAHIKEPEREGKGTD 282
G +++ EE + +L +DII + E I EP K +
Sbjct: 85 GSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKK--E 142
Query: 283 LEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSE 342
+ KDK + K P+R+ Q K++ +G+ +K + + +++K E
Sbjct: 143 IHKDKTEKQEK-------PERK-IQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKE 194
Query: 343 SGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRE 402
K + K+ K E EK++ V ++ +VK++ + V + Q+ K +E
Sbjct: 195 KPETKTLAKEQKKA-----KTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKE 249
Query: 403 SVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTE 462
++A V K E K + + D+ +++ +S A P Q
Sbjct: 250 KE--DKEKAAVSKHEQK----DQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPT 303
Query: 463 VSVP--ETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAE-KDPNKKEKGDK 519
+ P E E + KK+E V +KKE + K ++KE D E K+P K + +
Sbjct: 304 PASPALEEKEGEKKKAEKKVTS---ETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQ 360
Query: 520 NT----------KGDKGKDKVKGKRESEINGEKSKGSKRAK 550
T K +K +D K K+ +E+ E+ KG K+ K
Sbjct: 361 GTVKIAAQAAAKKDEKKEDSKKTKKPAEV--EQPKGKKQEK 399
Score = 46.6 bits (109), Expect = 6e-05
Identities = 54/255 (21%), Positives = 104/255 (40%), Gaps = 20/255 (7%)
Query: 324 KKSVSDVP-RGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQ 382
K + + P R +E K+E ++ Q + KG+E EK + + +
Sbjct: 130 KGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEK 189
Query: 383 VKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADV------P 436
++K + +K + KK ++ E EK++ +V G++ +V++T A V P
Sbjct: 190 IEKKEKPETKTLAKEQKKAKTA-----EKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTP 244
Query: 437 KEQEVQEKKSEAGVLKGPES-QVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKE---- 491
+ + +E K +A V K + Q + + +K +S + E+
Sbjct: 245 SKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTP 304
Query: 492 ---SFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKR 548
+ E+K K+ E+ + KKEK D K +K K+E E +G+ +
Sbjct: 305 ASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVK 364
Query: 549 AKANTGRKYNKKVEE 563
A K ++K E+
Sbjct: 365 IAAQAAAKKDEKKED 379
Score = 43.1 bits (100), Expect = 7e-04
Identities = 45/204 (22%), Positives = 86/204 (42%), Gaps = 11/204 (5%)
Query: 362 KGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVP 421
+G++ + EK +++E + K +S K V+K+E G+ ++ ++ +K+
Sbjct: 313 EGEKKKAEKKVTSETKKKEKEDIKKKS--EKETAIDVEKKEP----GKASETKQGTVKIA 366
Query: 422 KGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVL 481
+ ++ + D K ++ E + G K E + K+ E + E V +
Sbjct: 367 AQAAAKKDEKKEDSKKTKKPAEVEQPKG--KKQEKKEKHVEPAKSPKKEHSVPSDKQVKA 424
Query: 482 KGQEAQEKKESFEDKGNNDKEKERDAEKDPN---KKEKGDKNTKGDKGKDKVKGKRESEI 538
K + A+E+ + K +KE K +KEK K + K K+ +KGK E
Sbjct: 425 KTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVP 484
Query: 539 NGEKSKGSKRAKANTGRKYNKKVE 562
K K + K K K+V+
Sbjct: 485 ASLKEKEPETKKDEKMSKAGKEVK 508
>gi|44890059 involucrin [Homo sapiens]
Length = 585
Score = 58.9 bits (141), Expect = 1e-08
Identities = 58/243 (23%), Positives = 114/243 (46%), Gaps = 25/243 (10%)
Query: 267 KSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKS 326
+ +K +++ K +L + ++G ++ G PK E Q ++ + Q Q+K
Sbjct: 289 QEGQLKHLDQQEKQPELPEQQMGQLKHLEQQEGQPKHLEQQE--GQLEQLEEQEGQLKHL 346
Query: 327 VSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPR--RQESQVK 384
+ + + ++ + G+P+ Q Q+ + L +GQ +E+ E + +QE Q+K
Sbjct: 347 EQQEGQLEHLEHQEGQLGLPEQQVLQLKQ--LEKQQGQPKHLEEEEGQLKHLVQQEGQLK 404
Query: 385 K--SQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQ 442
Q G + QE QV+ E V + + + ++ +LK + Q+GQ+E E V + + ++
Sbjct: 405 HLVQQEGQLEQQERQVEHLEQQVGQLKHLEEQEGQLKHLEQQQGQLEVPEQQVGQPKNLE 464
Query: 443 EKKSEAGVLKGPESQVKNTE------------VSVPETLESQVK-----KSESGVLKGQE 485
+++ + + + E QVK+ E V P+ LE Q K + + G LK E
Sbjct: 465 QEEKQLELPEQQEGQVKHLEKQEAQLELPEQQVGQPKHLEQQEKHLEHPEQQDGQLKHLE 524
Query: 486 AQE 488
QE
Sbjct: 525 QQE 527
Score = 53.1 bits (126), Expect = 7e-07
Identities = 61/322 (18%), Positives = 147/322 (45%), Gaps = 21/322 (6%)
Query: 232 QILKCGGTARSQNSREENKEALK-------NDIIFTNSVESLKSAHIKE--PEREG--KG 280
Q LK T R Q ++ +E K +++ + +K + E ++EG K
Sbjct: 106 QQLKQEKTQRDQQLNKQLEEEKKLLDQQLDQELVKRDEQLGMKKEQLLELPEQQEGHLKH 165
Query: 281 TDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKK 340
+ ++ ++ + + +P++QE QL++ E Q + + ++ ++P QE Q++
Sbjct: 166 LEQQEGQLKHPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLEL 225
Query: 341 SESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKK 400
E + + Q + L + + QE Q+E SE + + + ++ Q V + Q Q+K
Sbjct: 226 PEQQEGQLELPQQQEGQLELSEQQEGQLELSEQQEGQLKHLEHQEGQLEVPEEQMGQLKY 285
Query: 401 RESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKN 460
E + + ++ + ++P+ Q GQ++ E + + +++++ + L+ E Q+K+
Sbjct: 286 LEQQEGQLKHLDQQEKQPELPEQQMGQLKHLEQQEGQPKHLEQQEGQLEQLEEQEGQLKH 345
Query: 461 TEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKN 520
E + + ++ + G+ + Q Q K+ EK++ K ++E K+
Sbjct: 346 LEQQEGQLEHLEHQEGQLGLPEQQVLQLKQ----------LEKQQGQPKHLEEEEGQLKH 395
Query: 521 TKGDKGKDKVKGKRESEINGEK 542
+G+ K ++E ++ ++
Sbjct: 396 LVQQEGQLKHLVQQEGQLEQQE 417
Score = 51.6 bits (122), Expect = 2e-06
Identities = 61/282 (21%), Positives = 127/282 (45%), Gaps = 43/282 (15%)
Query: 264 ESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQG----- 318
+ L+ H ++ E K + E+ + K D + K+ E + K+ + + Q
Sbjct: 85 QELQQQHWEQHEEYQKAENPEQQL--KQEKTQRDQQLNKQLEEEKKLLDQQLDQELVKRD 142
Query: 319 -QGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVE-----KSE 372
Q K+ + ++P QE +K E + + + + L + + QE Q+E + +
Sbjct: 143 EQLGMKKEQLLELPEQQEGHLKHLEQQEGQLKHPEQQEGQLELPEQQEGQLELPEQQEGQ 202
Query: 373 MGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTE 432
+ +P +QE Q++ + QE Q++ E + + Q ++ +L++ + QEGQ+E +E
Sbjct: 203 LELPEQQEGQLELPEQ-----QEGQLELPEQQEGQLELPQQQEGQLELSEQQEGQLELSE 257
Query: 433 ---------------ADVPKEQEVQEK--KSEAGVLKGPESQVKNTEVSVPETLESQVKK 475
+VP+EQ Q K + + G LK + Q K E +PE Q+K
Sbjct: 258 QQEGQLKHLEHQEGQLEVPEEQMGQLKYLEQQEGQLKHLDQQEKQPE--LPEQQMGQLKH 315
Query: 476 SESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKG 517
E Q+ + K + +G ++ +E++ + ++++G
Sbjct: 316 LE------QQEGQPKHLEQQEGQLEQLEEQEGQLKHLEQQEG 351
Score = 51.2 bits (121), Expect = 2e-06
Identities = 75/295 (25%), Positives = 134/295 (45%), Gaps = 55/295 (18%)
Query: 275 EREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQ 334
++EG+ LE + +EV P+ Q QLK E Q + ++ ++P Q
Sbjct: 258 QQEGQLKHLEHQEGQLEV--------PEEQMGQLKYLEQQEGQLKHLDQQEKQPELPEQQ 309
Query: 335 ESQVK--KSESGVPKGQEAQV--------TKSGLVVLKGQEAQVE-----KSEMGVPRRQ 379
Q+K + + G PK E Q + L L+ QE Q+E + ++G+P +Q
Sbjct: 310 MGQLKHLEQQEGQPKHLEQQEGQLEQLEEQEGQLKHLEQQEGQLEHLEHQEGQLGLPEQQ 369
Query: 380 ESQVKK--SQSGVSKG-------------QEAQVKK--RESVVLKGQEAQVEKSE----- 417
Q+K+ Q G K QE Q+K ++ L+ QE QVE E
Sbjct: 370 VLQLKQLEKQQGQPKHLEEEEGQLKHLVQQEGQLKHLVQQEGQLEQQERQVEHLEQQVGQ 429
Query: 418 LKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVK--- 474
LK + QEGQ++ E ++ +++ + + G K E + K E +PE E QVK
Sbjct: 430 LKHLEEQEGQLKHLE---QQQGQLEVPEQQVGQPKNLEQEEKQLE--LPEQQEGQVKHLE 484
Query: 475 KSESGV-LKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGD-KNTKGDKGK 527
K E+ + L Q+ + K + + + + +++D + ++++G K+ + KG+
Sbjct: 485 KQEAQLELPEQQVGQPKHLEQQEKHLEHPEQQDGQLKHLEQQEGQLKDLEQQKGQ 539
Score = 50.1 bits (118), Expect = 6e-06
Identities = 67/249 (26%), Positives = 113/249 (45%), Gaps = 36/249 (14%)
Query: 275 EREGKGTDLEKDKIGME--VKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPR 332
E+EG+ LE+ + +E + G+P++Q QLK ++ QGQ +++ +
Sbjct: 338 EQEGQLKHLEQQEGQLEHLEHQEGQLGLPEQQVLQLK--QLEKQQGQPKHLEEEEGQLKH 395
Query: 333 --GQESQVKK--SESGVPKGQEAQVTK-----SGLVVLKGQEAQV-----EKSEMGVPRR 378
QE Q+K + G + QE QV L L+ QE Q+ ++ ++ VP +
Sbjct: 396 LVQQEGQLKHLVQQEGQLEQQERQVEHLEQQVGQLKHLEEQEGQLKHLEQQQGQLEVPEQ 455
Query: 379 QESQVK-----KSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKV--PKGQEGQVEKT 431
Q Q K + Q + + QE QVK L+ QEAQ+E E +V PK E Q +
Sbjct: 456 QVGQPKNLEQEEKQLELPEQQEGQVKH-----LEKQEAQLELPEQQVGQPKHLEQQEKHL 510
Query: 432 EADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVK------KSESGVLKGQE 485
E ++ +++ + + G LK E Q E V QV+ ++ VL E
Sbjct: 511 EHPEQQDGQLKHLEQQEGQLKDLEQQKGQLEQPVFAPAPGQVQDIQPALPTKGEVLLPVE 570
Query: 486 AQEKKESFE 494
Q++K+ +
Sbjct: 571 HQQQKQEVQ 579
Score = 40.4 bits (93), Expect = 0.004
Identities = 41/203 (20%), Positives = 99/203 (48%), Gaps = 19/203 (9%)
Query: 329 DVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVK--KS 386
+VP QE + + G+P+ + Q K Q+ + E E Q+K K+
Sbjct: 54 EVPSKQEEKHMTAVKGLPEQECEQQQKEPQEQELQQQHWEQHEEYQKAENPEQQLKQEKT 113
Query: 387 QSGVSKGQEAQVKKR-------ESVVLKGQEAQVEKSE-LKVPKGQEGQVEKTEADVPKE 438
Q ++ + +K+ + +V + ++ ++K + L++P+ QEG ++ E +E
Sbjct: 114 QRDQQLNKQLEEEKKLLDQQLDQELVKRDEQLGMKKEQLLELPEQQEGHLKHLE---QQE 170
Query: 439 QEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVK--KSESGVLKGQEAQEKKESF--E 494
+++ + + G L+ PE Q ++ +PE E Q++ + + G L+ E QE + +
Sbjct: 171 GQLKHPEQQEGQLELPEQQ--EGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQ 228
Query: 495 DKGNNDKEKERDAEKDPNKKEKG 517
+G + ++++ + + +++++G
Sbjct: 229 QEGQLELPQQQEGQLELSEQQEG 251
Score = 31.6 bits (70), Expect = 2.0
Identities = 33/129 (25%), Positives = 61/129 (47%), Gaps = 9/129 (6%)
Query: 414 EKSELKVPKGQEGQVEKTEADVPKEQEVQ----EKKSEAGVLKGPESQVKNTEVSVPETL 469
E+ + KG Q + + P+EQE+Q E+ E + PE Q+K + + L
Sbjct: 60 EEKHMTAVKGLPEQECEQQQKEPQEQELQQQHWEQHEEYQKAENPEQQLKQEKTQRDQQL 119
Query: 470 ESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDK 529
Q+++ E +L Q QE + E G +KE+ E P ++E K+ + +G+ K
Sbjct: 120 NKQLEE-EKKLLDQQLDQELVKRDEQLG---MKKEQLLEL-PEQQEGHLKHLEQQEGQLK 174
Query: 530 VKGKRESEI 538
++E ++
Sbjct: 175 HPEQQEGQL 183
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 57.0 bits (136), Expect = 5e-08
Identities = 57/276 (20%), Positives = 140/276 (50%), Gaps = 17/276 (6%)
Query: 241 RSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGI 300
+ + RE+ ++ + + + E ++ E+E K +LE +K+ + K+
Sbjct: 307 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE-EKMHEQEKIREQE-- 363
Query: 301 PKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVV 360
KRQE + KI E Q Q A++ + + R QE ++++ E + + +E + +
Sbjct: 364 EKRQEEE-KIREQEKRQEQEAKMWRQEEKI-REQEEKIREQEEMMQEQEEKMGEQEEKMW 421
Query: 361 LKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKV 420
+ +E Q ++ +M RRQE ++++ + + + QE +++++E + ++ QE ++ + E K+
Sbjct: 422 EQEEEMQEQEEKM---RRQEEKIREQEKKIRE-QEEKIREQEEM-MQEQEEKMGEQEGKM 476
Query: 421 PKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGV 480
+ + E+ E +E++++E++ + ++ E +++ E + E E ++ E
Sbjct: 477 CEQEAKMQEQEEKMRRQEEKIREQEKK---IREQEEKIREQEEMMQEQEEKMWEQEEKMC 533
Query: 481 LKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEK 516
+ ++ QE+ E+K +EK R+ E ++E+
Sbjct: 534 EQEEKMQEQ----EEKMRRQEEKMREQEVRLRQQEE 565
Score = 49.3 bits (116), Expect = 9e-06
Identities = 61/319 (19%), Positives = 150/319 (47%), Gaps = 22/319 (6%)
Query: 258 IFTNSV--ESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSI 315
++ N++ E LK + K E+ + + EK +I + VK K + +L + + +
Sbjct: 197 LYRNTITDEELKEKNAKLQEKL-QLVESEKSEIQLNVKELKR----KLERAKLLLPQQQL 251
Query: 316 PQGQGAQIKKSVSDVPRGQESQVKKSE--SGVPKGQEAQVTKSGLVV------LKGQEAQ 367
Q + + K + V ++QV+++E + + + QE ++ + + ++ QE +
Sbjct: 252 -QAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEK 310
Query: 368 VEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQ 427
+ + E + R++E +K + + QE + ++E + + +E E+ +++ + + +
Sbjct: 311 IREQEEKMRRQEEMMWEKEEK--MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE 368
Query: 428 VEKT-EADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEA 486
EK E + +EQE + + E + + E +++ E + E E ++ E + +E
Sbjct: 369 EEKIREQEKRQEQEAKMWRQEEKI-REQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEM 427
Query: 487 QEKKESFEDKGNNDKEKERDAEKDPNK-KEKGDKNTKGDKGKDKVKGKR-ESEINGEKSK 544
QE++E + +E+E+ + K +E+ + + ++ + +GK E E ++ +
Sbjct: 428 QEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQE 487
Query: 545 GSKRAKANTGRKYNKKVEE 563
R + R+ KK+ E
Sbjct: 488 EKMRRQEEKIREQEKKIRE 506
Score = 46.2 bits (108), Expect = 8e-05
Identities = 57/287 (19%), Positives = 136/287 (47%), Gaps = 29/287 (10%)
Query: 264 ESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQL-----KISEMSIPQG 318
E ++ K E+E K + E+ E + +RQE + KI E+
Sbjct: 295 EKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH 354
Query: 319 QGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRR 378
+ +I++ + R +E ++++ E + QEA++ + QE ++ + E + R
Sbjct: 355 EQEKIREQ--EEKRQEEEKIREQEKR--QEQEAKMWR--------QEEKIREQEEKI-RE 401
Query: 379 QESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKE 438
QE +++ + + + +E ++ E ++ QE ++ + E K+ + QE ++ + E + ++
Sbjct: 402 QEEMMQEQEEKMGEQEEKMWEQEEE--MQEQEEKMRRQEEKI-REQEKKIREQEEKIREQ 458
Query: 439 QE-VQEKKSEAGVLKG----PESQVKNTEVSV---PETLESQVKKSESGVLKGQEAQEKK 490
+E +QE++ + G +G E++++ E + E + Q KK K +E +E
Sbjct: 459 EEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 518
Query: 491 ESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESE 537
+ E+K +EK + E+ ++E+ + + + +V+ +++ E
Sbjct: 519 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEE 565
>gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform a
[Homo sapiens]
Length = 845
Score = 56.2 bits (134), Expect = 8e-08
Identities = 58/250 (23%), Positives = 111/250 (44%), Gaps = 21/250 (8%)
Query: 333 GQESQVKKSESGVPKGQ-EAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVS 391
G S+ V KG+ + ++ K+ L ++ Q + E + +++ Q ++ Q
Sbjct: 16 GDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKK 75
Query: 392 KGQEAQVKKRESVVLKGQEAQV-------------EKSELKVPKGQEGQVEK---TEADV 435
K + ++++ V G+E ++ E+ E+ PK + G+ K A +
Sbjct: 76 KRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAAL 135
Query: 436 PKEQEVQEKKSEAGVLKG--PESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESF 493
++Q +E++ E K PE N VS + + KK + KG+ + K +
Sbjct: 136 IQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAA 195
Query: 494 EDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAKANT 553
D DKE+E EK+P K+ K +K K ++G ++ E E G +SK A+
Sbjct: 196 LDNEEEDKEEEIIKEKEPPKQGK-EKAKKAEQGSEEEGEGEEEEEEGGESKADD-PYAHL 253
Query: 554 GRKYNKKVEE 563
+K KK+++
Sbjct: 254 SKKEKKKLKK 263
Score = 43.5 bits (101), Expect = 5e-04
Identities = 58/272 (21%), Positives = 115/272 (42%), Gaps = 54/272 (19%)
Query: 283 LEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQV---- 338
+E + G E KV + ++Q+ Q + + +G+ KK V D G+E ++
Sbjct: 47 VEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR---KKDVDD--DGEEKELMERL 101
Query: 339 ---------KKSESGVPKGQEAQVTKSGLV---VLKGQEAQVEKSEMGVPRRQESQVKKS 386
++ E PK + + TK G V +++ Q + E+ E P+ + + +
Sbjct: 102 KKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRI 161
Query: 387 QSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKV-PKGQEGQVEKTEADVPKEQEVQEKK 445
VS+ Q+ LKG++ + EKS+ K P+ + ++ E D KE+E+ ++K
Sbjct: 162 NKAVSEEQQP--------ALKGKKGKEEKSKGKAKPQNKFAALDNEEED--KEEEIIKEK 211
Query: 446 SEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKER 505
P+ + + KK+E +G E + + E E++G K +
Sbjct: 212 EP------------------PKQGKEKAKKAE----QGSEEEGEGEEEEEEGGESKADDP 249
Query: 506 DAEKDPNKKEKGDKNTKGDKGKDKVKGKRESE 537
A +K+K K + ++ +K +E
Sbjct: 250 YAHLSKKEKKKLKKQMEYERQVASLKAANAAE 281
Score = 39.7 bits (91), Expect = 0.007
Identities = 38/197 (19%), Positives = 78/197 (39%), Gaps = 23/197 (11%)
Query: 254 KNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEM 313
K +F ++ +E + K EK++I V + + ++ + K
Sbjct: 127 KGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGK 186
Query: 314 SIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEM 373
+ PQ + A + D +E ++ K + +G+E + +K+E
Sbjct: 187 AKPQNKFAALDNEEED----KEEEIIKEKEPPKQGKE----------------KAKKAEQ 226
Query: 374 GVPRRQESQVKKSQSGVSKGQE--AQVKKRESVVLKGQ-EAQVEKSELKVPKGQEGQVEK 430
G E + ++ + G SK + A + K+E LK Q E + + + LK E
Sbjct: 227 GSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSV 286
Query: 431 TEADVPKEQEVQEKKSE 447
++A++ Q + E S+
Sbjct: 287 SQAEMSSRQAMLENASD 303
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 55.1 bits (131), Expect = 2e-07
Identities = 68/319 (21%), Positives = 129/319 (40%), Gaps = 22/319 (6%)
Query: 243 QNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEK----DKIGMEVKVDSDA 298
Q S E ++E K + ++ E L E K + LEK DK E V +
Sbjct: 663 QRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKER 722
Query: 299 GIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGL 358
+ ++ K SE S + + +K+ ++P ++S+ G A GL
Sbjct: 723 NFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSL------GMSAIEESIGL 776
Query: 359 VVLKGQEAQVEKSEMGVPRRQESQVKKSQ---SGVSKGQEAQVKKRESVVLKGQEAQVEK 415
+++ +E +EK E + +E K+SQ + K E + ++E + +++ +K
Sbjct: 777 HLVE-KEIDIEKQEKHIKESKEKPEKRSQIKEKDIEK-MERKTFEKEKKIKHEHKSEKDK 834
Query: 416 SELK--VPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQV 473
+L V K +E + +E ++ K+ A + K + + ++ E
Sbjct: 835 LDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPE 894
Query: 474 KKSESGVLKGQEAQEKKESFED-----KGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKD 528
K+ K + EKK D K K KE+D E D +K + ++ K
Sbjct: 895 KERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKH 954
Query: 529 KVKGKRESEINGEKSKGSK 547
+ K+ S ++G K++ K
Sbjct: 955 IQEEKKSSIVDGNKAQHEK 973
Score = 47.0 bits (110), Expect = 5e-05
Identities = 73/330 (22%), Positives = 132/330 (40%), Gaps = 22/330 (6%)
Query: 223 LAKKSCSKIQILKCGGTARSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTD 282
L KKS + I T S+E N + + D I S +S + IK+ + E +
Sbjct: 697 LEKKSKLEKNIKDDKSTKEKHVSKERNFKE-ERDKIKKESEKSFREEKIKDLKEERENIP 755
Query: 283 LEKDK----IGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQV 338
+KD +GM +S +E ++ E I + + K+S ++ +
Sbjct: 756 TDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMER 815
Query: 339 KKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQV 398
K E E + K L + + + EK ++ + K + G A +
Sbjct: 816 KTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTE----KCHKEGEKSKNTAAI 871
Query: 399 KKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQV 458
KK + K +E K + + P+ + E E + +++ Q SE + +++
Sbjct: 872 KKTDDRE-KSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKE 930
Query: 459 KNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNND--------KEKERDAE-K 509
K+ E+ + E K + + QE+K+S GN KEK +D K
Sbjct: 931 KDREL---DKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLK 987
Query: 510 DPNKKEKGDKNTKGDKGKDKVKGKRESEIN 539
P+ KEK K+ D+ K++ K K + +IN
Sbjct: 988 TPDGKEKDKKDKDIDRYKERDKHKDKIQIN 1017
Score = 32.3 bits (72), Expect = 1.2
Identities = 29/142 (20%), Positives = 56/142 (39%), Gaps = 3/142 (2%)
Query: 422 KGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVL 481
K E + EKT +E+ K ++ K +TE S E L+++ + V+
Sbjct: 364 KENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVI 423
Query: 482 ---KGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEI 538
+ Q KKE + K K + K+ NK ++ + + +GK+ + +
Sbjct: 424 PETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVN 483
Query: 539 NGEKSKGSKRAKANTGRKYNKK 560
G R + N + ++ K
Sbjct: 484 TGLDCSEKTREEGNFRKSFSPK 505
Score = 32.0 bits (71), Expect = 1.6
Identities = 48/246 (19%), Positives = 85/246 (34%), Gaps = 34/246 (13%)
Query: 319 QGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRR 378
Q +I S S +P S ++ + V G+ Q K LK Q E E+ +
Sbjct: 412 QNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRK-LKNQNKNKENQELKQEKE 470
Query: 379 QESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKE 438
+ + + V+ G + K RE + + + + L + G+ K + ++
Sbjct: 471 GKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEK 530
Query: 439 QEVQEKKSEAGVLKGPESQVKNTEVSVP--ETLESQVKKSESGVLKGQEAQEKKES---- 492
Q K+ P S + + + + ES+ S V + ++ K
Sbjct: 531 QSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFH 590
Query: 493 --FEDKGNN---------------------DKE----KERDAEKDPNKKEKGDKNTKGDK 525
F +K N DKE K+ + +KEK K +G+K
Sbjct: 591 LEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEK 650
Query: 526 GKDKVK 531
K K K
Sbjct: 651 EKYKTK 656
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 55.1 bits (131), Expect = 2e-07
Identities = 68/319 (21%), Positives = 129/319 (40%), Gaps = 22/319 (6%)
Query: 243 QNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEK----DKIGMEVKVDSDA 298
Q S E ++E K + ++ E L E K + LEK DK E V +
Sbjct: 686 QRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKER 745
Query: 299 GIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGL 358
+ ++ K SE S + + +K+ ++P ++S+ G A GL
Sbjct: 746 NFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSL------GMSAIEESIGL 799
Query: 359 VVLKGQEAQVEKSEMGVPRRQESQVKKSQ---SGVSKGQEAQVKKRESVVLKGQEAQVEK 415
+++ +E +EK E + +E K+SQ + K E + ++E + +++ +K
Sbjct: 800 HLVE-KEIDIEKQEKHIKESKEKPEKRSQIKEKDIEK-MERKTFEKEKKIKHEHKSEKDK 857
Query: 416 SELK--VPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQV 473
+L V K +E + +E ++ K+ A + K + + ++ E
Sbjct: 858 LDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPE 917
Query: 474 KKSESGVLKGQEAQEKKESFED-----KGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKD 528
K+ K + EKK D K K KE+D E D +K + ++ K
Sbjct: 918 KERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKH 977
Query: 529 KVKGKRESEINGEKSKGSK 547
+ K+ S ++G K++ K
Sbjct: 978 IQEEKKSSIVDGNKAQHEK 996
Score = 47.0 bits (110), Expect = 5e-05
Identities = 73/330 (22%), Positives = 132/330 (40%), Gaps = 22/330 (6%)
Query: 223 LAKKSCSKIQILKCGGTARSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTD 282
L KKS + I T S+E N + + D I S +S + IK+ + E +
Sbjct: 720 LEKKSKLEKNIKDDKSTKEKHVSKERNFKE-ERDKIKKESEKSFREEKIKDLKEERENIP 778
Query: 283 LEKDK----IGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQV 338
+KD +GM +S +E ++ E I + + K+S ++ +
Sbjct: 779 TDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMER 838
Query: 339 KKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQV 398
K E E + K L + + + EK ++ + K + G A +
Sbjct: 839 KTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTE----KCHKEGEKSKNTAAI 894
Query: 399 KKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQV 458
KK + K +E K + + P+ + E E + +++ Q SE + +++
Sbjct: 895 KKTDDRE-KSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKE 953
Query: 459 KNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNND--------KEKERDAE-K 509
K+ E+ + E K + + QE+K+S GN KEK +D K
Sbjct: 954 KDREL---DKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLK 1010
Query: 510 DPNKKEKGDKNTKGDKGKDKVKGKRESEIN 539
P+ KEK K+ D+ K++ K K + +IN
Sbjct: 1011 TPDGKEKDKKDKDIDRYKERDKHKDKIQIN 1040
Score = 32.3 bits (72), Expect = 1.2
Identities = 29/142 (20%), Positives = 56/142 (39%), Gaps = 3/142 (2%)
Query: 422 KGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVL 481
K E + EKT +E+ K ++ K +TE S E L+++ + V+
Sbjct: 387 KENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVI 446
Query: 482 ---KGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEI 538
+ Q KKE + K K + K+ NK ++ + + +GK+ + +
Sbjct: 447 PETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVN 506
Query: 539 NGEKSKGSKRAKANTGRKYNKK 560
G R + N + ++ K
Sbjct: 507 TGLDCSEKTREEGNFRKSFSPK 528
Score = 32.0 bits (71), Expect = 1.6
Identities = 48/246 (19%), Positives = 85/246 (34%), Gaps = 34/246 (13%)
Query: 319 QGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRR 378
Q +I S S +P S ++ + V G+ Q K LK Q E E+ +
Sbjct: 435 QNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRK-LKNQNKNKENQELKQEKE 493
Query: 379 QESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKE 438
+ + + V+ G + K RE + + + + L + G+ K + ++
Sbjct: 494 GKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEK 553
Query: 439 QEVQEKKSEAGVLKGPESQVKNTEVSVP--ETLESQVKKSESGVLKGQEAQEKKES---- 492
Q K+ P S + + + + ES+ S V + ++ K
Sbjct: 554 QSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFH 613
Query: 493 --FEDKGNN---------------------DKE----KERDAEKDPNKKEKGDKNTKGDK 525
F +K N DKE K+ + +KEK K +G+K
Sbjct: 614 LEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEK 673
Query: 526 GKDKVK 531
K K K
Sbjct: 674 EKYKTK 679
>gi|190014588 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo
sapiens]
Length = 530
Score = 54.7 bits (130), Expect = 2e-07
Identities = 59/235 (25%), Positives = 107/235 (45%), Gaps = 15/235 (6%)
Query: 337 QVKKSESGVPKGQEAQVTK-SGLVVLKGQEAQVEKS-EMGVPRRQESQVKKSQSGVSKGQ 394
+V++ E+ V K K S V K + K+ G R+ E QV+ ++GV
Sbjct: 109 EVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTA 168
Query: 395 EAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEK---TEADVPKEQEVQEKKSEAGVL 451
A V + S +G+ A E ++ P+G+ V++ +E+D+ E++ +KK +
Sbjct: 169 TASVNLKVSPK-RGRPAATEV-KIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEE-- 224
Query: 452 KGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKG---NNDKEKERDAE 508
K P+ Q K E E E + +K +E + K+++ G +D E+E D +
Sbjct: 225 KQPKKQPKKDEEGQKE--EDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGD-D 281
Query: 509 KDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAKANTGRKYNKKVEE 563
++ KK KG +N + ++ +KG+ E E K K ++ + K K E
Sbjct: 282 QEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPE 336
Score = 43.9 bits (102), Expect = 4e-04
Identities = 68/326 (20%), Positives = 134/326 (41%), Gaps = 30/326 (9%)
Query: 254 KNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEM 313
++DII K K+P+++ K KD+ G + + D P ++E + ++
Sbjct: 207 ESDIITEEDKSKKKGQEEKQPKKQPK-----KDEEGQKEE-DKPRKEPDKKEGKKEVESK 260
Query: 314 SIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEM 373
+ S S+ G + + +K G Q A +LKGQ EK
Sbjct: 261 RKNLAKTGVTSTSDSE-EEGDDQEGEKKRKGGRNFQTAHRRN----MLKGQH---EKEAA 312
Query: 374 GVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVE------KSELKVPKGQEGQ 427
R+QE Q++ Q +G++ +VKK E +++++ K+ LK+ +
Sbjct: 313 DRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNR 372
Query: 428 VEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVS--VPETLESQVKKSESGVLKGQE 485
+ ++ Q ++ + + +++ +VS + E K ++ L G+
Sbjct: 373 CIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEG 432
Query: 486 AQE-----KKESFEDKGNNDKEKERD-AEKDPNKK-EKGDKNTKGDKGKDKVKGKRESEI 538
K E + + + K +D +K PNKK EK +K G + + +
Sbjct: 433 DSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQH 492
Query: 539 NGEKSKGSK-RAKANTGRKYNKKVEE 563
NGE ++ SK +A+T +K + + E
Sbjct: 493 NGESNEDSKDNHEASTKKKPSSEERE 518
Score = 39.3 bits (90), Expect = 0.010
Identities = 53/255 (20%), Positives = 107/255 (41%), Gaps = 33/255 (12%)
Query: 239 TARSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKI------GMEV 292
T+ S+ + ++A D+ + + K+A + K + E+ + + +
Sbjct: 115 TSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNL 174
Query: 293 KVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQV-KKSESGVPKGQEA 351
KV G P T++KI + P+G+ +K+ P ES + + + KGQE
Sbjct: 175 KVSPKRGRPAA--TEVKIPK---PRGRPKMVKQ-----PCPSESDIITEEDKSKKKGQEE 224
Query: 352 QVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEA 411
+ K K +E Q E+ + PR++ + + + SK + S +E
Sbjct: 225 KQPKKQ--PKKDEEGQKEEDK---PRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEG 279
Query: 412 QVEKSELKVPKGQ-----------EGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKN 460
++ E K G+ +GQ EK AD ++QE Q + + +G + +VK
Sbjct: 280 DDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKK 339
Query: 461 TEVSVPETLESQVKK 475
E +++S++++
Sbjct: 340 VEKKRETSMDSRLQR 354
Score = 38.5 bits (88), Expect = 0.017
Identities = 58/224 (25%), Positives = 103/224 (45%), Gaps = 37/224 (16%)
Query: 332 RGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKK---SQS 388
R E QV+ E+GV A V + +G+ A E ++ PR + VK+ S+S
Sbjct: 151 RKAEKQVETEEAGVVTTATASVNLK-VSPKRGRPAATEV-KIPKPRGRPKMVKQPCPSES 208
Query: 389 GVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVP-KEQEVQEKKSE 447
+ ++ KK GQE + K + K K +EGQ E+ D P KE + +E K E
Sbjct: 209 DIITEEDKSKKK-------GQEEKQPKKQPK--KDEEGQKEE---DKPRKEPDKKEGKKE 256
Query: 448 AGVLKGPESQVKN-TEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERD 506
ES+ KN + V T +S+ + + QE ++K++ N R+
Sbjct: 257 V------ESKRKNLAKTGVTSTSDSEEEGDD------QEGEKKRKGGR---NFQTAHRRN 301
Query: 507 AEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAK 550
K ++KE D+ K + ++++ +++++ G+K + K K
Sbjct: 302 MLKGQHEKEAADRKRKQE---EQMETEQQNKDEGKKPEVKKVEK 342
>gi|19923653 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo
sapiens]
Length = 530
Score = 54.7 bits (130), Expect = 2e-07
Identities = 59/235 (25%), Positives = 107/235 (45%), Gaps = 15/235 (6%)
Query: 337 QVKKSESGVPKGQEAQVTK-SGLVVLKGQEAQVEKS-EMGVPRRQESQVKKSQSGVSKGQ 394
+V++ E+ V K K S V K + K+ G R+ E QV+ ++GV
Sbjct: 109 EVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTA 168
Query: 395 EAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEK---TEADVPKEQEVQEKKSEAGVL 451
A V + S +G+ A E ++ P+G+ V++ +E+D+ E++ +KK +
Sbjct: 169 TASVNLKVSPK-RGRPAATEV-KIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEE-- 224
Query: 452 KGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKG---NNDKEKERDAE 508
K P+ Q K E E E + +K +E + K+++ G +D E+E D +
Sbjct: 225 KQPKKQPKKDEEGQKE--EDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGD-D 281
Query: 509 KDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAKANTGRKYNKKVEE 563
++ KK KG +N + ++ +KG+ E E K K ++ + K K E
Sbjct: 282 QEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPE 336
Score = 43.9 bits (102), Expect = 4e-04
Identities = 68/326 (20%), Positives = 134/326 (41%), Gaps = 30/326 (9%)
Query: 254 KNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEM 313
++DII K K+P+++ K KD+ G + + D P ++E + ++
Sbjct: 207 ESDIITEEDKSKKKGQEEKQPKKQPK-----KDEEGQKEE-DKPRKEPDKKEGKKEVESK 260
Query: 314 SIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEM 373
+ S S+ G + + +K G Q A +LKGQ EK
Sbjct: 261 RKNLAKTGVTSTSDSE-EEGDDQEGEKKRKGGRNFQTAHRRN----MLKGQH---EKEAA 312
Query: 374 GVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVE------KSELKVPKGQEGQ 427
R+QE Q++ Q +G++ +VKK E +++++ K+ LK+ +
Sbjct: 313 DRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNR 372
Query: 428 VEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVS--VPETLESQVKKSESGVLKGQE 485
+ ++ Q ++ + + +++ +VS + E K ++ L G+
Sbjct: 373 CIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEG 432
Query: 486 AQE-----KKESFEDKGNNDKEKERD-AEKDPNKK-EKGDKNTKGDKGKDKVKGKRESEI 538
K E + + + K +D +K PNKK EK +K G + + +
Sbjct: 433 DSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQH 492
Query: 539 NGEKSKGSK-RAKANTGRKYNKKVEE 563
NGE ++ SK +A+T +K + + E
Sbjct: 493 NGESNEDSKDNHEASTKKKPSSEERE 518
Score = 39.3 bits (90), Expect = 0.010
Identities = 53/255 (20%), Positives = 107/255 (41%), Gaps = 33/255 (12%)
Query: 239 TARSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKI------GMEV 292
T+ S+ + ++A D+ + + K+A + K + E+ + + +
Sbjct: 115 TSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNL 174
Query: 293 KVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQV-KKSESGVPKGQEA 351
KV G P T++KI + P+G+ +K+ P ES + + + KGQE
Sbjct: 175 KVSPKRGRPAA--TEVKIPK---PRGRPKMVKQ-----PCPSESDIITEEDKSKKKGQEE 224
Query: 352 QVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEA 411
+ K K +E Q E+ + PR++ + + + SK + S +E
Sbjct: 225 KQPKKQ--PKKDEEGQKEEDK---PRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEG 279
Query: 412 QVEKSELKVPKGQ-----------EGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKN 460
++ E K G+ +GQ EK AD ++QE Q + + +G + +VK
Sbjct: 280 DDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKK 339
Query: 461 TEVSVPETLESQVKK 475
E +++S++++
Sbjct: 340 VEKKRETSMDSRLQR 354
Score = 38.5 bits (88), Expect = 0.017
Identities = 58/224 (25%), Positives = 103/224 (45%), Gaps = 37/224 (16%)
Query: 332 RGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKK---SQS 388
R E QV+ E+GV A V + +G+ A E ++ PR + VK+ S+S
Sbjct: 151 RKAEKQVETEEAGVVTTATASVNLK-VSPKRGRPAATEV-KIPKPRGRPKMVKQPCPSES 208
Query: 389 GVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVP-KEQEVQEKKSE 447
+ ++ KK GQE + K + K K +EGQ E+ D P KE + +E K E
Sbjct: 209 DIITEEDKSKKK-------GQEEKQPKKQPK--KDEEGQKEE---DKPRKEPDKKEGKKE 256
Query: 448 AGVLKGPESQVKN-TEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERD 506
ES+ KN + V T +S+ + + QE ++K++ N R+
Sbjct: 257 V------ESKRKNLAKTGVTSTSDSEEEGDD------QEGEKKRKGGR---NFQTAHRRN 301
Query: 507 AEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAK 550
K ++KE D+ K + ++++ +++++ G+K + K K
Sbjct: 302 MLKGQHEKEAADRKRKQE---EQMETEQQNKDEGKKPEVKKVEK 342
>gi|150378549 tangerin [Homo sapiens]
Length = 1523
Score = 53.5 bits (127), Expect = 5e-07
Identities = 70/287 (24%), Positives = 124/287 (43%), Gaps = 37/287 (12%)
Query: 239 TARSQNSREENKEALKNDIIFTNSVES--LKSAHIKEPEREGKGTDLEKDKIGMEVKVDS 296
TAR RE E ++DI+ +E L I+ EG +G +
Sbjct: 730 TARDSGVREIEAEIAESDILVAQEIEVGLLGVLGIETGAAEGA-------ILGTQEIASR 782
Query: 297 DAGIPKRQETQLKISEMSIPQGQGAQIKK-SVSDVPRGQESQVKKSESGVPKGQEAQVTK 355
D+G+P + G Q+K+ S+VP E +E+ + QE
Sbjct: 783 DSGVPGLEADTT-----------GIQVKEVGGSEVP---EIATGTAETEILGTQEIASRS 828
Query: 356 SGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEK 415
SG+ L+ + A +++E+G S + ++G+++ + +K E +V + ++ + +
Sbjct: 829 SGVPGLESEVAGAQETEVG-----GSGISGPEAGMAEARVLMTRKTEIIVPEAEKEEAQT 883
Query: 416 SELKVPKGQEGQVEKTEA-----DVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLE 470
S ++ + + G K EA P+ QE K+E ++G E+QV V E
Sbjct: 884 SGVQEAETRVGSALKYEALRAPVTQPRVLGSQEAKAEISGVQGSETQV--LRVQEAEAGV 941
Query: 471 SQVKKSESGVLKGQEAQEK-KESFEDKGNNDKEKERDAEKDPNKKEK 516
+ + +SG QEA+ K ES E+K K +E +A N+K K
Sbjct: 942 WGMSEGKSGAWGAQEAEMKVLESPENKSGTFKAQEAEAGVLGNEKGK 988
Score = 46.6 bits (109), Expect = 6e-05
Identities = 50/225 (22%), Positives = 101/225 (44%), Gaps = 16/225 (7%)
Query: 260 TNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQ 319
++ V L+S E E G+ + + GM ++A + ++T++ + E + Q
Sbjct: 828 SSGVPGLESEVAGAQETEVGGSGISGPEAGM-----AEARVLMTRKTEIIVPEAEKEEAQ 882
Query: 320 GAQIKKSVSDVPRGQESQVKKSESGVPK---GQEAQVTKSGLVVLKGQEAQVEKSEMGVP 376
+ ++++ + V + + ++ P+ QEA+ SG+ + Q +V+++E GV
Sbjct: 883 TSGVQEAETRVGSALKYEALRAPVTQPRVLGSQEAKAEISGVQGSETQVLRVQEAEAGVW 942
Query: 377 RRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKV---PKGQEGQVEKTEA 433
E + SG QEA++K ES K + +++E V KG+E + TEA
Sbjct: 943 GMSEGK-----SGAWGAQEAEMKVLESPENKSGTFKAQEAEAGVLGNEKGKEAEGSLTEA 997
Query: 434 DVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSES 478
+P+ Q + A PE ++ + + + V S+S
Sbjct: 998 SLPEAQVASGAGAGAPRASSPEKAEEDRRLPGSQAPPALVSSSQS 1042
Score = 38.1 bits (87), Expect = 0.022
Identities = 73/327 (22%), Positives = 133/327 (40%), Gaps = 54/327 (16%)
Query: 273 EPEREGKGT-DLEKDKIGMEV-----KVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKS 326
E E G G + E + +G+EV K +G P+ + +++I GA K++
Sbjct: 561 EAEAGGSGDLETETEVVGLEVLGTQEKEVEGSGFPETRTLEIEIL--------GALEKEA 612
Query: 327 VSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQV---EKSEMGVPRRQESQV 383
R ES+V + + +G E Q T+ G++ G E +V +K+E G +++
Sbjct: 613 ARS--RVLESEV--AGTAQCEGLETQETEVGVIETPGTETEVLGTQKTEAGGSGVLQTRT 668
Query: 384 KKSQSGVSKGQEAQ-----VKKRESV---VLKGQEAQVEKSELKVPKGQEGQVEKTEADV 435
+++ V QE +K +++ +L QE +VE S +VP E + E TEA +
Sbjct: 669 TIAETEVLVTQEISGDLGPLKIEDTIQSEMLGTQETEVEAS--RVP---ESEAEGTEAKI 723
Query: 436 PKEQEVQEKKS-----EAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKK 490
QE+ + S EA + + + EV + L + +E +L QE +
Sbjct: 724 LGTQEITARDSGVREIEAEIAESDILVAQEIEVGLLGVLGIETGAAEGAILGTQEIASRD 783
Query: 491 E---SFEDKGNNDKEKERDAEKDP------------NKKEKGDKNTKGDKGKDKVKGKRE 535
E + KE + P +E +++ + +V G +E
Sbjct: 784 SGVPGLEADTTGIQVKEVGGSEVPEIATGTAETEILGTQEIASRSSGVPGLESEVAGAQE 843
Query: 536 SEINGEKSKGSKRAKANTGRKYNKKVE 562
+E+ G G + A +K E
Sbjct: 844 TEVGGSGISGPEAGMAEARVLMTRKTE 870
Score = 32.3 bits (72), Expect = 1.2
Identities = 52/250 (20%), Positives = 93/250 (37%), Gaps = 48/250 (19%)
Query: 298 AGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRG------------QESQVKKSESGV 345
AG+ +ETQ + + GA++ S+ D G +++ + SGV
Sbjct: 333 AGLGSARETQAQACPQEGTEAHGARLGPSIEDKGSGDPFGRQRLKAEEMDTEDRPEASGV 392
Query: 346 PK-----GQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVK----KSQSGVSKGQEA 396
G+EA +SG ++ EA+ + V Q S+V+ K EA
Sbjct: 393 DTEPRSGGREANTKRSG---VRAGEAEESSAVCQVDAEQRSKVRHVDTKGPEATGVMPEA 449
Query: 397 QVKKRESVVLKGQEAQV-------EKSELKVP-------KGQEGQVEKTEADVPKEQEVQ 442
+ + +G + ++ S L +P GQ G +E A +E+E
Sbjct: 450 RCRGTPEAPPRGSQGRLGVRTRDEAPSGLSLPPAEPAGHSGQLGDLEGARAAAGQEREGA 509
Query: 443 EKKSEA------GVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDK 496
E + A G+ +GP +T V + + ++ + +G E E
Sbjct: 510 EVRGGAPGIEGTGLEQGPSVGAISTRPQVSSWQGALLSTAQGAISRGLGGWEA----EAG 565
Query: 497 GNNDKEKERD 506
G+ D E E +
Sbjct: 566 GSGDLETETE 575
Score = 32.3 bits (72), Expect = 1.2
Identities = 49/199 (24%), Positives = 83/199 (41%), Gaps = 22/199 (11%)
Query: 319 QGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRR 378
QGA + + + RG ++E+G E + GL VL QE +VE S R
Sbjct: 542 QGALLSTAQGAISRGLGGW--EAEAGGSGDLETETEVVGLEVLGTQEKEVEGSGFPETRT 599
Query: 379 QESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKE 438
E ++ G + + A+ + ES V AQ E E QE +V E +
Sbjct: 600 LEIEI----LGALEKEAARSRVLESEV--AGTAQCEGLET-----QETEVGVIETPGTET 648
Query: 439 QEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGN 498
+ + +K+EAG G T ++ E L +Q + G LK +++ + +
Sbjct: 649 EVLGTQKTEAG---GSGVLQTRTTIAETEVLVTQEISGDLGPLK------IEDTIQSEML 699
Query: 499 NDKEKERDAEKDPNKKEKG 517
+E E +A + P + +G
Sbjct: 700 GTQETEVEASRVPESEAEG 718
>gi|190014586 PC4 and SFRS1 interacting protein 1 isoform 1 [Homo
sapiens]
Length = 333
Score = 53.1 bits (126), Expect = 7e-07
Identities = 56/216 (25%), Positives = 101/216 (46%), Gaps = 15/216 (6%)
Query: 337 QVKKSESGVPKGQEAQVTK-SGLVVLKGQEAQVEKS-EMGVPRRQESQVKKSQSGVSKGQ 394
+V++ E+ V K K S V K + K+ G R+ E QV+ ++GV
Sbjct: 109 EVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTA 168
Query: 395 EAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEK---TEADVPKEQEVQEKKSEAGVL 451
A V + S +G+ A E ++ P+G+ V++ +E+D+ E++ +KK +
Sbjct: 169 TASVNLKVSPK-RGRPAATEV-KIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEE-- 224
Query: 452 KGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKG---NNDKEKERDAE 508
K P+ Q K E E E + +K +E + K+++ G +D E+E D +
Sbjct: 225 KQPKKQPKKDEEGQKE--EDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGD-D 281
Query: 509 KDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSK 544
++ KK KG +N + ++ +KG+ E E K K
Sbjct: 282 QEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRK 317
Score = 47.8 bits (112), Expect = 3e-05
Identities = 48/198 (24%), Positives = 89/198 (44%), Gaps = 15/198 (7%)
Query: 365 EAQVEKSEMGVPRRQ-ESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKG 423
+ +VE+ E V + + + K S V+K + K + + K+E +V
Sbjct: 107 DVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKA------ARRGRKRKAEKQVETE 160
Query: 424 QEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQV-KKSESGVLK 482
+ G V A V + + + A +K P+ + + V P ES + + + K
Sbjct: 161 EAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKK 220
Query: 483 GQEAQEKKESFEDKGNNDKEKERDA-EKDPNKKE--KGDKNTKGDKGKDKVKGKRESEIN 539
GQE ++ K+ + K + + +KE D K+P+KKE K ++ + + K V +SE
Sbjct: 221 GQEEKQPKK--QPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEE 278
Query: 540 GEKSKGSKRAKANTGRKY 557
G+ +G K+ K GR +
Sbjct: 279 GDDQEGEKKRKG--GRNF 294
Score = 36.6 bits (83), Expect = 0.063
Identities = 50/191 (26%), Positives = 78/191 (40%), Gaps = 29/191 (15%)
Query: 394 QEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEK-TEADVPKEQEVQEKKS-EAGVL 451
Q+A K+ + + +VE+ E V K EK + DV K ++ K+ G
Sbjct: 95 QQAATKQSNA----SSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRK 150
Query: 452 KGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGN------------- 498
+ E QV+ E V T + V S +G+ A + + + +G
Sbjct: 151 RKAEKQVETEEAGVVTTATASVNLKVSPK-RGRPAATEVKIPKPRGRPKMVKQPCPSESD 209
Query: 499 ----NDKEKER-DAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAK-AN 552
DK K++ EK P K+ K D+ +G K +DK + K + G+K SKR A
Sbjct: 210 IITEEDKSKKKGQEEKQPKKQPKKDE--EGQKEEDKPR-KEPDKKEGKKEVESKRKNLAK 266
Query: 553 TGRKYNKKVEE 563
TG EE
Sbjct: 267 TGVTSTSDSEE 277
Score = 36.2 bits (82), Expect = 0.082
Identities = 54/199 (27%), Positives = 89/199 (44%), Gaps = 34/199 (17%)
Query: 332 RGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKK---SQS 388
R E QV+ E+GV A V + +G+ A E ++ PR + VK+ S+S
Sbjct: 151 RKAEKQVETEEAGVVTTATASVNLK-VSPKRGRPAATEV-KIPKPRGRPKMVKQPCPSES 208
Query: 389 GVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVP-KEQEVQEKKSE 447
+ ++ KK GQE + K + K K +EGQ E+ D P KE + +E K E
Sbjct: 209 DIITEEDKSKKK-------GQEEKQPKKQPK--KDEEGQKEE---DKPRKEPDKKEGKKE 256
Query: 448 AGVLKGPESQVKN-TEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERD 506
ES+ KN + V T +S+ + + QE ++K++ N R+
Sbjct: 257 V------ESKRKNLAKTGVTSTSDSEEEGDD------QEGEKKRKGGR---NFQTAHRRN 301
Query: 507 AEKDPNKKEKGDKNTKGDK 525
K ++KE D+ K ++
Sbjct: 302 MLKGQHEKEAADRKRKQEE 320
>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 53.1 bits (126), Expect = 7e-07
Identities = 70/333 (21%), Positives = 139/333 (41%), Gaps = 57/333 (17%)
Query: 229 SKIQILKCGGTARSQNSREENKEALKN--DIIFTNSVESLKSAHIKE-PEREGKGTDLEK 285
S +L+C +++ ++ EE E + D V L+ +K P T L+K
Sbjct: 1089 SSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKK 1148
Query: 286 DKIGMEVKVDSDAGIPKR--QETQLKISEMSIPQGQGAQIKKSVSDVPR-GQESQVKKSE 342
K + K KR ++ K+S +P A + + + +P+ G++ ++++SE
Sbjct: 1149 KKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESE 1208
Query: 343 SGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRE 402
V K +M +P ++ + +E Q + E
Sbjct: 1209 ETVEP----------------------KEDMPLPEERKEE-----------EEMQAEAEE 1235
Query: 403 SVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGP-ESQVKNT 461
+ +G+E SE VP + KE EV+E++ + V + +S+ +
Sbjct: 1236 AE--EGEEEDAASSE--VPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQ 1291
Query: 462 EVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPN----KKEKG 517
E+ PE E + +E+ +A + ED G+ + K+++ E+ P K+E G
Sbjct: 1292 ELEEPEPEEEEDAAAETAQNDDHDADD-----EDDGHLESTKKKELEEQPTREDVKEEPG 1346
Query: 518 DKNTKGD----KGKDKVKGKRESEINGEKSKGS 546
+ + D K ++K+K K E+E++ E+ + S
Sbjct: 1347 VQESFLDANMQKSREKIKDKEETELDSEEEQPS 1379
Score = 35.0 bits (79), Expect = 0.18
Identities = 23/74 (31%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Query: 112 SRSSIGSIKCLQTTEEPPSRTAGAMMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYPGSN 171
S SS+ C+ T + ++ +MMQ ++ P A IK Q +V+ P P Q
Sbjct: 1594 SSSSLTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERP-PSNQQQQPP 1652
Query: 172 AGPPSAPRGPPMAP 185
PP P+ PP P
Sbjct: 1653 PPPPQQPQPPPPQP 1666
>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 53.1 bits (126), Expect = 7e-07
Identities = 70/333 (21%), Positives = 139/333 (41%), Gaps = 57/333 (17%)
Query: 229 SKIQILKCGGTARSQNSREENKEALKN--DIIFTNSVESLKSAHIKE-PEREGKGTDLEK 285
S +L+C +++ ++ EE E + D V L+ +K P T L+K
Sbjct: 1089 SSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKK 1148
Query: 286 DKIGMEVKVDSDAGIPKR--QETQLKISEMSIPQGQGAQIKKSVSDVPR-GQESQVKKSE 342
K + K KR ++ K+S +P A + + + +P+ G++ ++++SE
Sbjct: 1149 KKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESE 1208
Query: 343 SGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRE 402
V K +M +P ++ + +E Q + E
Sbjct: 1209 ETVEP----------------------KEDMPLPEERKEE-----------EEMQAEAEE 1235
Query: 403 SVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGP-ESQVKNT 461
+ +G+E SE VP + KE EV+E++ + V + +S+ +
Sbjct: 1236 AE--EGEEEDAASSE--VPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQ 1291
Query: 462 EVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPN----KKEKG 517
E+ PE E + +E+ +A + ED G+ + K+++ E+ P K+E G
Sbjct: 1292 ELEEPEPEEEEDAAAETAQNDDHDADD-----EDDGHLESTKKKELEEQPTREDVKEEPG 1346
Query: 518 DKNTKGD----KGKDKVKGKRESEINGEKSKGS 546
+ + D K ++K+K K E+E++ E+ + S
Sbjct: 1347 VQESFLDANMQKSREKIKDKEETELDSEEEQPS 1379
Score = 35.0 bits (79), Expect = 0.18
Identities = 23/74 (31%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Query: 112 SRSSIGSIKCLQTTEEPPSRTAGAMMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYPGSN 171
S SS+ C+ T + ++ +MMQ ++ P A IK Q +V+ P P Q
Sbjct: 1594 SSSSLTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERP-PSNQQQQPP 1652
Query: 172 AGPPSAPRGPPMAP 185
PP P+ PP P
Sbjct: 1653 PPPPQQPQPPPPQP 1666
>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 53.1 bits (126), Expect = 7e-07
Identities = 70/333 (21%), Positives = 139/333 (41%), Gaps = 57/333 (17%)
Query: 229 SKIQILKCGGTARSQNSREENKEALKN--DIIFTNSVESLKSAHIKE-PEREGKGTDLEK 285
S +L+C +++ ++ EE E + D V L+ +K P T L+K
Sbjct: 1089 SSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKK 1148
Query: 286 DKIGMEVKVDSDAGIPKR--QETQLKISEMSIPQGQGAQIKKSVSDVPR-GQESQVKKSE 342
K + K KR ++ K+S +P A + + + +P+ G++ ++++SE
Sbjct: 1149 KKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESE 1208
Query: 343 SGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRE 402
V K +M +P ++ + +E Q + E
Sbjct: 1209 ETVEP----------------------KEDMPLPEERKEE-----------EEMQAEAEE 1235
Query: 403 SVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGP-ESQVKNT 461
+ +G+E SE VP + KE EV+E++ + V + +S+ +
Sbjct: 1236 AE--EGEEEDAASSE--VPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQ 1291
Query: 462 EVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPN----KKEKG 517
E+ PE E + +E+ +A + ED G+ + K+++ E+ P K+E G
Sbjct: 1292 ELEEPEPEEEEDAAAETAQNDDHDADD-----EDDGHLESTKKKELEEQPTREDVKEEPG 1346
Query: 518 DKNTKGD----KGKDKVKGKRESEINGEKSKGS 546
+ + D K ++K+K K E+E++ E+ + S
Sbjct: 1347 VQESFLDANMQKSREKIKDKEETELDSEEEQPS 1379
Score = 35.0 bits (79), Expect = 0.18
Identities = 23/74 (31%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Query: 112 SRSSIGSIKCLQTTEEPPSRTAGAMMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYPGSN 171
S SS+ C+ T + ++ +MMQ ++ P A IK Q +V+ P P Q
Sbjct: 1594 SSSSLTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERP-PSNQQQQPP 1652
Query: 172 AGPPSAPRGPPMAP 185
PP P+ PP P
Sbjct: 1653 PPPPQQPQPPPPQP 1666
>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 1 [Homo sapiens]
Length = 1099
Score = 53.1 bits (126), Expect = 7e-07
Identities = 67/308 (21%), Positives = 121/308 (39%), Gaps = 46/308 (14%)
Query: 218 YMDEELAKKSCSKIQIL----KCGGTARSQNSREENKEALKNDIIFT--NSVESLKSAHI 271
++ E+L+++ +K+ L K G A + + ++NK+ LK + T +S SL ++ I
Sbjct: 609 WVKEQLSRRPVAKVMALEDLSKPGDGAIAVDELQDNKK-LKLPSLLTRGSSSTSLHNSTI 667
Query: 272 K-----------EPERE---GKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQ 317
+ +P RE K + E G + + A +E K+ +++
Sbjct: 668 RSTIYQLMLHSLDPLREVRLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTP 727
Query: 318 GQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKG-----QEAQVEKSE 372
IK + P GQE + +G G+E + G K E + E
Sbjct: 728 APVPDIKGDQKENPGGQEDVAEAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETET 787
Query: 373 MGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTE 432
G E + + G ++G++ E +KG E + E EL
Sbjct: 788 QGKGEECEDENEAEGKGDNEGEDEGEIHAEDGEMKGNEGETESQELSA------------ 835
Query: 433 ADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKES 492
E + K E GV G S ++E E E + ++ E + +E +E++E
Sbjct: 836 -----ENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEE---EQEEEEEEEEE 887
Query: 493 FEDKGNND 500
E+KGN +
Sbjct: 888 EEEKGNEE 895
Score = 39.3 bits (90), Expect = 0.010
Identities = 36/151 (23%), Positives = 63/151 (41%), Gaps = 10/151 (6%)
Query: 414 EKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQV 473
EK E + +G Q + P+E+E K V P +K + P E
Sbjct: 690 EKEEESLNQGARAQPQAKAESKPEEEE-PAKLPAVTVTPAPVPDIKGDQKENPGGQEDVA 748
Query: 474 KKSESGVLKGQEAQEKKES-FEDKGNNDKEKERDAEKDPNKK--EKGDKNTKGDKGKDKV 530
+ +G + G+E + E E+K + + E + E + K E D+N KG +
Sbjct: 749 EAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGDN-- 806
Query: 531 KGKRESEINGEKSKGSKRAKANTGRKYNKKV 561
+G+ E EI+ E + K N G ++++
Sbjct: 807 EGEDEGEIHAEDGE----MKGNEGETESQEL 833
Score = 35.0 bits (79), Expect = 0.18
Identities = 45/195 (23%), Positives = 79/195 (40%), Gaps = 17/195 (8%)
Query: 364 QEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESV-VLKGQEAQVEKSELKVPK 422
+E ++ K + Q ++ + SK +E + K +V V ++ + + P
Sbjct: 683 REVRLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPG 742
Query: 423 GQE--------GQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVK 474
GQE G++ E + E E +EK +G PE + + E E + +
Sbjct: 743 GQEDVAEAESTGEMPGEEGETAGEGETEEK---SGGETQPEGEGETETQGKGEECEDENE 799
Query: 475 KSESGVLKGQEAQE-KKESFEDKGN--NDKEKERDAEKDPNKK--EKGDKNTKGDKGKDK 529
G +G++ E E E KGN + +E AE K EKG ++ G G D
Sbjct: 800 AEGKGDNEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDS 859
Query: 530 VKGKRESEINGEKSK 544
+ + E E E+ +
Sbjct: 860 EEEEEEEEEQEEEEE 874
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 52.8 bits (125), Expect = 8e-07
Identities = 64/292 (21%), Positives = 133/292 (45%), Gaps = 34/292 (11%)
Query: 278 GKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVP-RGQES 336
G +D E + +G DS+ I + Q++ SE QI S S+ P R Q S
Sbjct: 141 GHASDSENEDVGKHPASDSE--IEELQKSPASDSETE--DALKPQISDSESEEPPRHQAS 196
Query: 337 QVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQS----GVSK 392
+ E P+ +++ + + QV SE P R ++ +++ +S
Sbjct: 197 DSENEEPPKPRMSDSESEEL-------PKPQVSDSESEEPPRHQASDSENEELPKPRISD 249
Query: 393 GQEAQVKKRESVVLKGQEA---QVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAG 449
+ + ++ + +E ++ SE + P + + E ++PK + V + +SE G
Sbjct: 250 SESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENE-ELPKPR-VSDSESE-G 306
Query: 450 VLKGPESQVKNTEVS----VPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEK-- 503
KGP S + + S PE+ + +++ KG++ + + +SF + D++K
Sbjct: 307 PQKGPASDSETEDASRHKQKPESDDDSDREN-----KGEDTEMQNDSFHSDSHMDRKKFH 361
Query: 504 ERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAKANTGR 555
D+E++ +KK+K D + +G+++ KR++ + + S+ ++A A R
Sbjct: 362 SSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSD-SEDEEKASAKKSR 412
Score = 38.9 bits (89), Expect = 0.013
Identities = 52/257 (20%), Positives = 95/257 (36%), Gaps = 39/257 (15%)
Query: 273 EPEREGKGTDLEKDKIGMEVKVDSD-AGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVP 331
E R+ G+D E +++ DS+ + K + +I E+ + S S+
Sbjct: 123 EETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQ-------KSPASDSETE 175
Query: 332 RGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVS 391
+ Q+ SES P +A + E E PR +S+ ++
Sbjct: 176 DALKPQISDSESEEPPRHQA--------------SDSENEEPPKPRMSDSESEELPKPQV 221
Query: 392 KGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVL 451
E++ R Q + E EL P+ + + E D P+ Q + E
Sbjct: 222 SDSESEEPPRH------QASDSENEELPKPRISDSESE----DPPRHQASDSENEEL--- 268
Query: 452 KGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDP 511
P+ ++ ++E P +Q SE+ L + + KG + DA +
Sbjct: 269 --PKPRISDSESEDPP--RNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHK 324
Query: 512 NKKEKGDKNTKGDKGKD 528
K E D + + +KG+D
Sbjct: 325 QKPESDDDSDRENKGED 341
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 52.4 bits (124), Expect = 1e-06
Identities = 57/288 (19%), Positives = 117/288 (40%), Gaps = 9/288 (3%)
Query: 277 EGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQES 336
+ G + + + V D D P+ + + + E I + S D P +
Sbjct: 1205 QSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLE-EIKANLSSDEDGSSDDEPEEGKK 1263
Query: 337 QVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEA 396
+ K P +EA+ V ++ E+S+ R + + K + S G+E
Sbjct: 1264 RTGKQNEENPGDEEAKNQ-----VNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEK 1318
Query: 397 QVKKRESVVLKGQEAQVEKSELKVPKG-QEGQVEKTEADVPKEQEVQEKKSEAGVLKGPE 455
+ K +E +KG+ + SE QE V + ++ EQ + + ++ L+ E
Sbjct: 1319 KTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELE--E 1376
Query: 456 SQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKE 515
+Q + ++ Q S +E +E+KE E++ ++E+E D D
Sbjct: 1377 NQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPG 1436
Query: 516 KGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAKANTGRKYNKKVEE 563
KG K + DK++ + ++ + E+ + + A+ R+ ++V E
Sbjct: 1437 KGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIE 1484
Score = 47.0 bits (110), Expect = 5e-05
Identities = 86/415 (20%), Positives = 151/415 (36%), Gaps = 63/415 (15%)
Query: 194 RIPQVHTMDSSGKITLTPVVILTGYMDEELAKKSCSKIQILKCGGTARSQNSREENKEAL 253
R P+V T PV T DEE + K K R ++ R + A+
Sbjct: 617 RSPRVKTTPLRRPTETNPV---TSNSDEECNETVKEK---QKLSVPVRKKDKRNSSDSAI 670
Query: 254 KN------------DIIFTNSVESLKSAHIKEPER----EGKGTDLE------KDKIGME 291
N + + NS A +KE R TD+ K ++
Sbjct: 671 DNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLK 730
Query: 292 VKVDSDAGIPKRQETQLKISEMSIPQGQGAQI------KKSVSDVPRGQESQVKKSESGV 345
+ D +++++ S+ +G+ A+ K+ +S+++K +
Sbjct: 731 TQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSM 790
Query: 346 PKGQEAQVTKSGLVVLKGQEAQVEK--SEMGVPRRQESQVKKSQSGVSKGQEAQVKKRES 403
K A+ TK + K ++ ++ S+ G+ + +K SQ G S E +K+E
Sbjct: 791 SKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAE---RKQER 847
Query: 404 VVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEV 463
E V+K + + + +PK+Q+ L G E + EV
Sbjct: 848 ETFSSAEGTVDK---------DTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEV 898
Query: 464 -SVPETLESQVKKSESGVLKGQEA-QEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNT 521
V ET E K Q+ + E F K +D+ E D ++ E+ K +
Sbjct: 899 RKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPS 958
Query: 522 KGDKGKDKVKGKRESEINGEKS-----------KGSKRAKANT--GRKYNKKVEE 563
K K++ + ES +G + KG K+ K T G K +KK+ +
Sbjct: 959 DFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRD 1013
Score = 46.6 bits (109), Expect = 6e-05
Identities = 74/362 (20%), Positives = 142/362 (39%), Gaps = 58/362 (16%)
Query: 241 RSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKD-KIGMEVKVDSDAG 299
+ + + K + T +S KS+ I + +R+ + D ++ E+K S G
Sbjct: 735 KDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIG 794
Query: 300 --------IPKRQETQLKISEMSIPQGQGAQIKKSVS--------DVPRGQESQVKKSES 343
IP ++ E +G Q K++ D R QE + S
Sbjct: 795 AARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAE 854
Query: 344 G--------------VPKGQEAQVTKSGLVVLKGQE--------AQVEKSEMGVPRRQES 381
G +PK Q+A + G+ L G+E +V +++ +
Sbjct: 855 GTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTK 914
Query: 382 QVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEV 441
KK Q G+S E +KK +S E SE + ++G EK + K++ +
Sbjct: 915 TCKKVQDGLSDIAEKFLKKDQS---------DETSEDDKKQSKKGTEEKKKPSDFKKKVI 965
Query: 442 QEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDK 501
+ ++ G E + E+ +K+ ++G G ++K + DK + K
Sbjct: 966 KMEQQYESSSDGTEKLPEREEIC---HFPKGIKQIKNGTTDG---EKKSKKIRDKTSKKK 1019
Query: 502 EKERD-AEKDPNKKEKGDKNTKGDKGKDKVKG--KRESEINGEKSKGSKRAKANTGRKYN 558
++ D AEK K + D +++ K K+ G K+ ++ G+ S+ + ++ KY+
Sbjct: 1020 DELSDYAEKSTGKGDSCD-SSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYS 1078
Query: 559 KK 560
K
Sbjct: 1079 MK 1080
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.124 0.328
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,190,946
Number of Sequences: 37866
Number of extensions: 1106854
Number of successful extensions: 11972
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 291
Number of HSP's successfully gapped in prelim test: 849
Number of HSP's that attempted gapping in prelim test: 5986
Number of HSP's gapped (non-prelim): 3895
length of query: 563
length of database: 18,247,518
effective HSP length: 107
effective length of query: 456
effective length of database: 14,195,856
effective search space: 6473310336
effective search space used: 6473310336
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.